Protein IDs	CQ/control	t test p value	protein_name	gene_id	gene_name	GO annotations	Pathways
Q96QD8	4.042958	0.000491063	Sodium-coupled neutral amino acid transporter 2	54407	SLC38A2	GO:0032328(BP:alanine transport);GO:0003333(BP:amino acid transmembrane transport);GO:0006865(BP:amino acid transport);GO:0034198(BP:cellular response to amino acid starvation);GO:0071260(BP:cellular response to mechanical stimulus);GO:0021987(BP:cerebral cortex development);GO:0007565(BP:female pregnancy);GO:0014047(BP:glutamate secretion);GO:0031460(BP:glycine betaine transport);GO:0006814(BP:sodium ion transport);GO:0030424(CC:axon);GO:0005903(CC:brush border);GO:0030425(CC:dendrite);GO:0005887(CC:integral component of plasma membrane);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0042383(CC:sarcolemma);GO:0015171(MF:amino acid transmembrane transporter activity);GO:0015186(MF:L-glutamine transmembrane transporter activity);GO:0015293(MF:symporter activity)	hsa04727(GABAergic synapse);hsa04974(Protein digestion and absorption);hsa04724(Glutamatergic synapse)
P52569	3.605328	0.001590158	Cationic amino acid transporter 2	6542	SLC7A2	GO:0006865(BP:amino acid transport);GO:0006520(BP:cellular amino acid metabolic process);GO:0097638(BP:L-arginine import across plasma membrane);GO:1903352(BP:L-ornithine transmembrane transport);GO:0042116(BP:macrophage activation);GO:0006809(BP:nitric oxide biosynthetic process);GO:0002537(BP:nitric oxide production involved in inflammatory response);GO:0050727(BP:regulation of inflammatory response);GO:0043030(BP:regulation of macrophage activation);GO:0030054(CC:cell junction);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0015171(MF:amino acid transmembrane transporter activity);GO:0015181(MF:arginine transmembrane transporter activity);GO:0015174(MF:basic amino acid transmembrane transporter activity);GO:0061459(MF:L-arginine transmembrane transporter activity);GO:0015189(MF:L-lysine transmembrane transporter activity);GO:0000064(MF:L-ornithine transmembrane transporter activity)	-
P02649	3.120111	0.000228414	Apolipoprotein E	348	APOE	"GO:0097113(BP:AMPA glutamate receptor clustering);GO:0042982(BP:amyloid precursor protein metabolic process);GO:0048844(BP:artery morphogenesis);GO:0006874(BP:cellular calcium ion homeostasis);GO:0044267(BP:cellular protein metabolic process);GO:0019934(BP:cGMP-mediated signaling);GO:0006695(BP:cholesterol biosynthetic process);GO:0006707(BP:cholesterol catabolic process);GO:0033344(BP:cholesterol efflux);GO:0042632(BP:cholesterol homeostasis);GO:0008203(BP:cholesterol metabolic process);GO:0034378(BP:chylomicron assembly);GO:0034382(BP:chylomicron remnant clearance);GO:0034371(BP:chylomicron remodeling);GO:0007010(BP:cytoskeleton organization);GO:0055089(BP:fatty acid homeostasis);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0034380(BP:high-density lipoprotein particle assembly);GO:0034384(BP:high-density lipoprotein particle clearance);GO:0034375(BP:high-density lipoprotein particle remodeling);GO:0071831(BP:intermediate-density lipoprotein particle clearance);GO:0046907(BP:intracellular transport);GO:0010877(BP:lipid transport involved in lipid storage);GO:0042158(BP:lipoprotein biosynthetic process);GO:0042159(BP:lipoprotein catabolic process);GO:0042157(BP:lipoprotein metabolic process);GO:0035641(BP:locomotory exploration behavior);GO:0015909(BP:long-chain fatty acid transport);GO:0007616(BP:long-term memory);GO:0034374(BP:low-density lipoprotein particle remodeling);GO:0051651(BP:maintenance of location in cell);GO:1902430(BP:negative regulation of amyloid-beta formation);GO:0030195(BP:negative regulation of blood coagulation);GO:0043537(BP:negative regulation of blood vessel endothelial cell migration);GO:0090090(BP:negative regulation of canonical Wnt signaling pathway);GO:0032269(BP:negative regulation of cellular protein metabolic process);GO:0045541(BP:negative regulation of cholesterol biosynthetic process);GO:0090370(BP:negative regulation of cholesterol efflux);GO:0061000(BP:negative regulation of dendritic spine development);GO:1902951(BP:negative regulation of dendritic spine maintenance);GO:0010596(BP:negative regulation of endothelial cell migration);GO:0001937(BP:negative regulation of endothelial cell proliferation);GO:0010629(BP:negative regulation of gene expression);GO:0050728(BP:negative regulation of inflammatory response);GO:0051055(BP:negative regulation of lipid biosynthetic process);GO:1903001(BP:negative regulation of lipid transport across blood brain barrier);GO:1900272(BP:negative regulation of long-term synaptic potentiation);GO:0043407(BP:negative regulation of MAP kinase activity);GO:0043524(BP:negative regulation of neuron apoptotic process);GO:1901215(BP:negative regulation of neuron death);GO:0010977(BP:negative regulation of neuron projection development);GO:1902999(BP:negative regulation of phospholipid efflux);GO:0010544(BP:negative regulation of platelet activation);GO:1901627(BP:negative regulation of postsynaptic membrane organization);GO:1901630(BP:negative regulation of presynaptic membrane organization);GO:0050709(BP:negative regulation of protein secretion);GO:0090209(BP:negative regulation of triglyceride metabolic process);GO:0031175(BP:neuron projection development);GO:0007263(BP:nitric oxide mediated signal transduction);GO:0097114(BP:NMDA glutamate receptor clustering);GO:0033700(BP:phospholipid efflux);GO:0044794(BP:positive regulation by host of viral process);GO:1905908(BP:positive regulation of amyloid fibril formation);GO:1902004(BP:positive regulation of amyloid-beta formation);GO:0010875(BP:positive regulation of cholesterol efflux);GO:0010873(BP:positive regulation of cholesterol esterification);GO:0060999(BP:positive regulation of dendritic spine development);GO:1902952(BP:positive regulation of dendritic spine maintenance);GO:0045807(BP:positive regulation of endocytosis);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:1905855(BP:positive regulation of heparan sulfate binding);GO:1905860(BP:positive regulation of heparan sulfate proteoglycan binding);GO:0046889(BP:positive regulation of lipid biosynthetic process);GO:1903002(BP:positive regulation of lipid transport across blood brain barrier);GO:0032805(BP:positive regulation of low-density lipoprotein particle receptor catabolic process);GO:0051044(BP:positive regulation of membrane protein ectodomain proteolysis);GO:1902998(BP:positive regulation of neurofibrillary tangle assembly);GO:1901216(BP:positive regulation of neuron death);GO:0010976(BP:positive regulation of neuron projection development);GO:0051000(BP:positive regulation of nitric-oxide synthase activity);GO:1902995(BP:positive regulation of phospholipid efflux);GO:1901628(BP:positive regulation of postsynaptic membrane organization);GO:1901631(BP:positive regulation of presynaptic membrane organization);GO:0045893(BP:positive regulation of transcription, DNA-templated);GO:0043687(BP:post-translational protein modification);GO:0017038(BP:protein import);GO:0006898(BP:receptor-mediated endocytosis);GO:1905906(BP:regulation of amyloid fibril formation);GO:1900221(BP:regulation of amyloid-beta clearance);GO:0030516(BP:regulation of axon extension);GO:2000822(BP:regulation of behavioral fear response);GO:0032489(BP:regulation of Cdc42 protein signal transduction);GO:1905890(BP:regulation of cellular response to very-low-density lipoprotein particle stimulus);GO:0090181(BP:regulation of cholesterol metabolic process);GO:0032374(BP:regulation of cholesterol transport);GO:0045088(BP:regulation of innate immune response);GO:1901214(BP:regulation of neuron death);GO:0048168(BP:regulation of neuronal synaptic plasticity);GO:0061136(BP:regulation of proteasomal protein catabolic process);GO:0032462(BP:regulation of protein homooligomerization);GO:0051246(BP:regulation of protein metabolic process);GO:1902947(BP:regulation of tau-protein kinase activity);GO:0006357(BP:regulation of transcription by RNA polymerase II);GO:0061771(BP:response to caloric restriction);GO:0002021(BP:response to dietary excess);GO:0000302(BP:response to reactive oxygen species);GO:0001523(BP:retinoid metabolic process);GO:0043691(BP:reverse cholesterol transport);GO:0007271(BP:synaptic transmission, cholinergic);GO:0019433(BP:triglyceride catabolic process);GO:0070328(BP:triglyceride homeostasis);GO:0006641(BP:triglyceride metabolic process);GO:0071830(BP:triglyceride-rich lipoprotein particle clearance);GO:0042311(BP:vasodilation);GO:0034447(BP:very-low-density lipoprotein particle clearance);GO:0034372(BP:very-low-density lipoprotein particle remodeling);GO:0019068(BP:virion assembly);GO:0072562(CC:blood microparticle);GO:0042627(CC:chylomicron);GO:0030669(CC:clathrin-coated endocytic vesicle membrane);GO:0005737(CC:cytoplasm);GO:0030425(CC:dendrite);GO:0034365(CC:discoidal high-density lipoprotein particle);GO:0005769(CC:early endosome);GO:0071682(CC:endocytic vesicle lumen);GO:0005783(CC:endoplasmic reticulum);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1903561(CC:extracellular vesicle);GO:0098978(CC:glutamatergic synapse);GO:0005794(CC:Golgi apparatus);GO:0034364(CC:high-density lipoprotein particle);GO:0034363(CC:intermediate-density lipoprotein particle);GO:1990777(CC:lipoprotein particle);GO:0034362(CC:low-density lipoprotein particle);GO:0016020(CC:membrane);GO:0043025(CC:neuronal cell body);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0043083(CC:synaptic cleft);GO:0034361(CC:very-low-density lipoprotein particle);GO:0001540(MF:amyloid-beta binding);GO:0016209(MF:antioxidant activity);GO:0015485(MF:cholesterol binding);GO:0017127(MF:cholesterol transporter activity);GO:0043395(MF:heparan sulfate proteoglycan binding);GO:0008201(MF:heparin binding);GO:0042802(MF:identical protein binding);GO:0008289(MF:lipid binding);GO:0005319(MF:lipid transporter activity);GO:0071813(MF:lipoprotein particle binding);GO:0050750(MF:low-density lipoprotein particle receptor binding);GO:0046911(MF:metal chelating activity);GO:0060228(MF:phosphatidylcholine-sterol O-acyltransferase activator activity);GO:0005543(MF:phospholipid binding);GO:0046983(MF:protein dimerization activity);GO:0042803(MF:protein homodimerization activity);GO:0044877(MF:protein-containing complex binding);GO:0005102(MF:signaling receptor binding);GO:0005198(MF:structural molecule activity);GO:0048156(MF:tau protein binding);GO:0070326(MF:very-low-density lipoprotein particle receptor binding)"	hsa04979(Cholesterol metabolism);hsa05010(Alzheimer disease)
Q9Y287	2.901701	0.001639337	Integral membrane protein 2B	9445	ITM2B	GO:0044267(BP:cellular protein metabolic process);GO:0042985(BP:negative regulation of amyloid precursor protein biosynthetic process);GO:0007399(BP:nervous system development);GO:0010008(CC:endosome membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0030660(CC:Golgi-associated vesicle membrane);GO:0031301(CC:integral component of organelle membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0001540(MF:amyloid-beta binding);GO:0005524(MF:ATP binding)	-
P04035	2.891395	0.009998219	3-hydroxy-3-methylglutaryl-coenzyme A reductase	3156	HMGCR	GO:0007568(BP:aging);GO:0006695(BP:cholesterol biosynthetic process);GO:0015936(BP:coenzyme A metabolic process);GO:0008299(BP:isoprenoid biosynthetic process);GO:0045445(BP:myoblast differentiation);GO:1900222(BP:negative regulation of amyloid-beta clearance);GO:0097756(BP:negative regulation of blood vessel diameter);GO:0061179(BP:negative regulation of insulin secretion involved in cellular response to glucose stimulus);GO:0043407(BP:negative regulation of MAP kinase activity);GO:0042177(BP:negative regulation of protein catabolic process);GO:0050709(BP:negative regulation of protein secretion);GO:0010664(BP:negative regulation of striated muscle cell apoptotic process);GO:0061045(BP:negative regulation of wound healing);GO:0010666(BP:positive regulation of cardiac muscle cell apoptotic process);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:0048643(BP:positive regulation of skeletal muscle tissue development);GO:0048661(BP:positive regulation of smooth muscle cell proliferation);GO:0032874(BP:positive regulation of stress-activated MAPK cascade);GO:0051262(BP:protein tetramerization);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0019216(BP:regulation of lipid metabolic process);GO:0045471(BP:response to ethanol);GO:0007584(BP:response to nutrient);GO:0016126(BP:sterol biosynthetic process);GO:0006743(BP:ubiquinone metabolic process);GO:0008542(BP:visual learning);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0005778(CC:peroxisomal membrane);GO:0050662(MF:coenzyme binding);GO:0004420(MF:hydroxymethylglutaryl-CoA reductase (NADPH) activity);GO:0042282(MF:hydroxymethylglutaryl-CoA reductase activity);GO:0070402(MF:NADPH binding);GO:0042803(MF:protein homodimerization activity);GO:0051721(MF:protein phosphatase 2A binding)	hsa00900(Terpenoid backbone biosynthesis);hsa04976(Bile secretion);hsa04152(AMPK signaling pathway)
Q15012	2.86692	0.001714124	Lysosomal-associated transmembrane protein 4A	9741	LAPTM4A	GO:0005794(CC:Golgi apparatus);GO:0016021(CC:integral component of membrane);GO:0031902(CC:late endosome membrane);GO:0005765(CC:lysosomal membrane);GO:0016020(CC:membrane)	hsa04142(Lysosome)
P04114	2.864483	5.37E-06	Apolipoprotein B-100	338	APOB	GO:0048844(BP:artery morphogenesis);GO:0044267(BP:cellular protein metabolic process);GO:0071379(BP:cellular response to prostaglandin stimulus);GO:0071356(BP:cellular response to tumor necrosis factor);GO:0033344(BP:cholesterol efflux);GO:0042632(BP:cholesterol homeostasis);GO:0008203(BP:cholesterol metabolic process);GO:0030301(BP:cholesterol transport);GO:0034378(BP:chylomicron assembly);GO:0034382(BP:chylomicron remnant clearance);GO:0034371(BP:chylomicron remodeling);GO:0009566(BP:fertilization);GO:0030317(BP:flagellated sperm motility);GO:0001701(BP:in utero embryonic development);GO:0050900(BP:leukocyte migration);GO:0042158(BP:lipoprotein biosynthetic process);GO:0042159(BP:lipoprotein catabolic process);GO:0042953(BP:lipoprotein transport);GO:0034383(BP:low-density lipoprotein particle clearance);GO:0034374(BP:low-density lipoprotein particle remodeling);GO:0061024(BP:membrane organization);GO:0007399(BP:nervous system development);GO:0010886(BP:positive regulation of cholesterol storage);GO:0010628(BP:positive regulation of gene expression);GO:0010884(BP:positive regulation of lipid storage);GO:0010744(BP:positive regulation of macrophage derived foam cell differentiation);GO:0009791(BP:post-embryonic development);GO:0043687(BP:post-translational protein modification);GO:0006898(BP:receptor-mediated endocytosis);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0009743(BP:response to carbohydrate);GO:0032355(BP:response to estradiol);GO:0032496(BP:response to lipopolysaccharide);GO:0010269(BP:response to selenium ion);GO:0009615(BP:response to virus);GO:0001523(BP:retinoid metabolic process);GO:0007283(BP:spermatogenesis);GO:0002224(BP:toll-like receptor signaling pathway);GO:0019433(BP:triglyceride catabolic process);GO:0006642(BP:triglyceride mobilization);GO:0034379(BP:very-low-density lipoprotein particle assembly);GO:0034447(BP:very-low-density lipoprotein particle clearance);GO:0042627(CC:chylomicron);GO:0034360(CC:chylomicron remnant);GO:0030669(CC:clathrin-coated endocytic vesicle membrane);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005769(CC:early endosome);GO:0071682(CC:endocytic vesicle lumen);GO:0070971(CC:endoplasmic reticulum exit site);GO:0005788(CC:endoplasmic reticulum lumen);GO:0005789(CC:endoplasmic reticulum membrane);GO:0031904(CC:endosome lumen);GO:0010008(CC:endosome membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0034364(CC:high-density lipoprotein particle);GO:0034363(CC:intermediate-density lipoprotein particle);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0034362(CC:low-density lipoprotein particle);GO:0043202(CC:lysosomal lumen);GO:0034359(CC:mature chylomicron);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0005790(CC:smooth endoplasmic reticulum);GO:0034361(CC:very-low-density lipoprotein particle);GO:0031983(CC:vesicle lumen);GO:0017127(MF:cholesterol transporter activity);GO:0008201(MF:heparin binding);GO:0035473(MF:lipase binding);GO:0050750(MF:low-density lipoprotein particle receptor binding);GO:0005543(MF:phospholipid binding);GO:0005102(MF:signaling receptor binding)	hsa04975(Fat digestion and absorption);hsa04979(Cholesterol metabolism);hsa04977(Vitamin digestion and absorption)
Q13772	2.760015	6.14E-05	Nuclear receptor coactivator 4	8031	NCOA4	"GO:0030521(BP:androgen receptor signaling pathway);GO:0006879(BP:cellular iron ion homeostasis);GO:0008584(BP:male gonad development);GO:0045893(BP:positive regulation of transcription, DNA-templated);GO:0006622(BP:protein targeting to lysosome);GO:0044754(CC:autolysosome);GO:0005634(CC:nucleus);GO:0050681(MF:androgen receptor binding);GO:0003713(MF:transcription coactivator activity)"	hsa04216(Ferroptosis);hsa05216(Thyroid cancer);hsa05200(Pathways in cancer)
O14763	2.706682	6.90E-06	Tumor necrosis factor receptor superfamily member 10B	8795	TNFRSF10B	GO:0006919(BP:activation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0007250(BP:activation of NF-kappaB-inducing kinase activity);GO:0006915(BP:apoptotic process);GO:0007166(BP:cell surface receptor signaling pathway);GO:0071260(BP:cellular response to mechanical stimulus);GO:0008625(BP:extrinsic apoptotic signaling pathway via death domain receptors);GO:0070059(BP:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress);GO:0050900(BP:leukocyte migration);GO:1902042(BP:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors);GO:0043065(BP:positive regulation of apoptotic process);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0042981(BP:regulation of apoptotic process);GO:1902041(BP:regulation of extrinsic apoptotic signaling pathway via death domain receptors);GO:0034976(BP:response to endoplasmic reticulum stress);GO:0036462(BP:TRAIL-activated apoptotic signaling pathway);GO:0009986(CC:cell surface);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0038023(MF:signaling receptor activity);GO:0045569(MF:TRAIL binding)	hsa05162(Measles);hsa04210(Apoptosis);hsa04060(Cytokine-cytokine receptor interaction);hsa05164(Influenza A);hsa04115(p53 signaling pathway);hsa04217(Necroptosis);hsa04650(Natural killer cell mediated cytotoxicity)
P0C0L4	2.614456	5.92E-06	Complement C4-A	720	C4A	"GO:0044267(BP:cellular protein metabolic process);GO:0006956(BP:complement activation);GO:0006958(BP:complement activation, classical pathway);GO:0006954(BP:inflammatory response);GO:0045087(BP:innate immune response);GO:2000427(BP:positive regulation of apoptotic cell clearance);GO:0043687(BP:post-translational protein modification);GO:0030449(BP:regulation of complement activation);GO:0030424(CC:axon);GO:0072562(CC:blood microparticle);GO:0030054(CC:cell junction);GO:0030425(CC:dendrite);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0045202(CC:synapse);GO:0001849(MF:complement component C1q binding);GO:0004866(MF:endopeptidase inhibitor activity)"	hsa04610(Complement and coagulation cascades);hsa05150(Staphylococcus aureus infection);hsa05133(Pertussis);hsa05322(Systemic lupus erythematosus)
O75204	2.585101	0.000511506	Transmembrane protein 127	55654	TMEM127	GO:0007032(BP:endosome organization);GO:0008285(BP:negative regulation of cell proliferation);GO:0032007(BP:negative regulation of TOR signaling);GO:0005737(CC:cytoplasm);GO:0005769(CC:early endosome);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0017137(MF:Rab GTPase binding)	-
Q9NQX7	2.549688	0.005808019	Integral membrane protein 2C	81618	ITM2C	GO:0042985(BP:negative regulation of amyloid precursor protein biosynthetic process);GO:0010977(BP:negative regulation of neuron projection development);GO:0030182(BP:neuron differentiation);GO:2001238(BP:positive regulation of extrinsic apoptotic signaling pathway);GO:0070062(CC:extracellular exosome);GO:0005794(CC:Golgi apparatus);GO:0016021(CC:integral component of membrane);GO:0005765(CC:lysosomal membrane);GO:0005764(CC:lysosome);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0001540(MF:amyloid-beta binding);GO:0005524(MF:ATP binding)	-
Q06033	2.362944	0.000315552	Inter-alpha-trypsin inhibitor heavy chain H3	3699	ITIH3	GO:0030212(BP:hyaluronan metabolic process);GO:0002576(BP:platelet degranulation);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0031089(CC:platelet dense granule lumen);GO:0004866(MF:endopeptidase inhibitor activity);GO:0004867(MF:serine-type endopeptidase inhibitor activity)	-
P00750	2.300428	0.033995645	Tissue-type plasminogen activator	5327	PLAT	"GO:0007596(BP:blood coagulation);GO:0006464(BP:cellular protein modification process);GO:0042730(BP:fibrinolysis);GO:0045861(BP:negative regulation of proteolysis);GO:0031639(BP:plasminogen activation);GO:0048008(BP:platelet-derived growth factor receptor signaling pathway);GO:0006508(BP:proteolysis);GO:0001666(BP:response to hypoxia);GO:0014909(BP:smooth muscle cell migration);GO:0099183(BP:trans-synaptic signaling by BDNF, modulating synaptic transmission);GO:0045177(CC:apical part of cell);GO:0009986(CC:cell surface);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0098978(CC:glutamatergic synapse);GO:0098685(CC:Schaffer collateral - CA1 synapse);GO:0030141(CC:secretory granule);GO:0051219(MF:phosphoprotein binding);GO:0004252(MF:serine-type endopeptidase activity);GO:0005102(MF:signaling receptor binding)"	hsa05202(Transcriptional misregulation in cancer);hsa05418(Fluid shear stress and atherosclerosis);hsa05215(Prostate cancer);hsa04610(Complement and coagulation cascades);hsa04371(Apelin signaling pathway)
Q86SJ2	2.271825	5.53E-05	Amphoterin-induced protein 2	347902	AMIGO2	GO:0007420(BP:brain development);GO:0007157(BP:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules);GO:0007156(BP:homophilic cell adhesion via plasma membrane adhesion molecules);GO:0043066(BP:negative regulation of apoptotic process);GO:0043069(BP:negative regulation of programmed cell death);GO:0051965(BP:positive regulation of synapse assembly);GO:0016021(CC:integral component of membrane);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane)	-
Q8NC42	2.17187	0.000294795	E3 ubiquitin-protein ligase RNF149	284996	RNF149	GO:0035690(BP:cellular response to drug);GO:0043409(BP:negative regulation of MAPK cascade);GO:0031647(BP:regulation of protein stability);GO:0006511(BP:ubiquitin-dependent protein catabolic process);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0046872(MF:metal ion binding);GO:0061630(MF:ubiquitin protein ligase activity)	-
P05067	2.122159	1.22E-06	Amyloid-beta precursor protein	351	APP	GO:0000187(BP:activation of MAPK activity);GO:0000185(BP:activation of MAPKKK activity);GO:0007189(BP:adenylate cyclase-activating G-protein coupled receptor signaling pathway);GO:0007193(BP:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0008344(BP:adult locomotory behavior);GO:1990000(BP:amyloid fibril formation);GO:0019731(BP:antibacterial humoral response);GO:0019732(BP:antifungal humoral response);GO:0061844(BP:antimicrobial humoral immune response mediated by antimicrobial peptide);GO:0008306(BP:associative learning);GO:0048143(BP:astrocyte activation);GO:0002265(BP:astrocyte activation involved in immune response);GO:0008088(BP:axo-dendritic transport);GO:0016199(BP:axon midline choice point recognition);GO:0007409(BP:axonogenesis);GO:0019722(BP:calcium-mediated signaling);GO:0007155(BP:cell adhesion);GO:0006878(BP:cellular copper ion homeostasis);GO:0009987(BP:cellular process);GO:0044267(BP:cellular protein metabolic process);GO:1904646(BP:cellular response to amyloid-beta);GO:0071320(BP:cellular response to cAMP);GO:0071280(BP:cellular response to copper ion);GO:0071287(BP:cellular response to manganese ion);GO:1990090(BP:cellular response to nerve growth factor stimulus);GO:0071874(BP:cellular response to norepinephrine stimulus);GO:0008203(BP:cholesterol metabolic process);GO:0050890(BP:cognition);GO:0048669(BP:collateral sprouting in absence of injury);GO:0050829(BP:defense response to Gram-negative bacterium);GO:0050830(BP:defense response to Gram-positive bacterium);GO:0016358(BP:dendrite development);GO:0006897(BP:endocytosis);GO:0030198(BP:extracellular matrix organization);GO:0030900(BP:forebrain development);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0045087(BP:innate immune response);GO:0035235(BP:ionotropic glutamate receptor signaling pathway);GO:0007612(BP:learning);GO:0007611(BP:learning or memory);GO:0042157(BP:lipoprotein metabolic process);GO:0007626(BP:locomotory behavior);GO:0007617(BP:mating behavior);GO:0007613(BP:memory);GO:0014005(BP:microglia development);GO:0001774(BP:microglial cell activation);GO:0090647(BP:modulation of age-related behavioral decline);GO:0098815(BP:modulation of excitatory postsynaptic potential);GO:0006378(BP:mRNA polyadenylation);GO:1903523(BP:negative regulation of blood circulation);GO:0090090(BP:negative regulation of canonical Wnt signaling pathway);GO:0008285(BP:negative regulation of cell proliferation);GO:0010629(BP:negative regulation of gene expression);GO:1900272(BP:negative regulation of long-term synaptic potentiation);GO:0010823(BP:negative regulation of mitochondrion organization);GO:1901215(BP:negative regulation of neuron death);GO:0045665(BP:negative regulation of neuron differentiation);GO:1902894(BP:negative regulation of pri-miRNA transcription by RNA polymerase II);GO:1900181(BP:negative regulation of protein localization to nucleus);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0050885(BP:neuromuscular process controlling balance);GO:0051402(BP:neuron apoptotic process);GO:0031175(BP:neuron projection development);GO:1990535(BP:neuron projection maintenance);GO:0016322(BP:neuron remodeling);GO:0007219(BP:Notch signaling pathway);GO:0002576(BP:platelet degranulation);GO:0061903(BP:positive regulation of 1-phosphatidylinositol-3-kinase activity);GO:1905908(BP:positive regulation of amyloid fibril formation);GO:1902004(BP:positive regulation of amyloid-beta formation);GO:0043065(BP:positive regulation of apoptotic process);GO:1902961(BP:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process);GO:0061890(BP:positive regulation of astrocyte activation);GO:0050867(BP:positive regulation of cell activation);GO:1905893(BP:positive regulation of cellular response to thapsigargin);GO:1905896(BP:positive regulation of cellular response to tunicamycin);GO:0045080(BP:positive regulation of chemokine biosynthetic process);GO:0043280(BP:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0007204(BP:positive regulation of cytosolic calcium ion concentration);GO:0051091(BP:positive regulation of DNA binding transcription factor activity);GO:1904472(BP:positive regulation of endothelin secretion);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:2000463(BP:positive regulation of excitatory postsynaptic potential);GO:1904022(BP:positive regulation of G-protein coupled receptor internalization);GO:0045745(BP:positive regulation of G-protein coupled receptor protein signaling pathway);GO:0010971(BP:positive regulation of G2/M transition of mitotic cell cycle);GO:0010628(BP:positive regulation of gene expression);GO:0035066(BP:positive regulation of histone acetylation);GO:0050725(BP:positive regulation of interleukin-1 beta biosynthetic process);GO:0045410(BP:positive regulation of interleukin-6 biosynthetic process);GO:0046330(BP:positive regulation of JNK cascade);GO:1900273(BP:positive regulation of long-term synaptic potentiation);GO:0043410(BP:positive regulation of MAPK cascade);GO:0051044(BP:positive regulation of membrane protein ectodomain proteolysis);GO:1903980(BP:positive regulation of microglial cell activation);GO:0045931(BP:positive regulation of mitotic cell cycle);GO:0090026(BP:positive regulation of monocyte chemotaxis);GO:0043525(BP:positive regulation of neuron apoptotic process);GO:1901216(BP:positive regulation of neuron death);GO:0045666(BP:positive regulation of neuron differentiation);GO:0051092(BP:positive regulation of NF-kappaB transcription factor activity);GO:1901224(BP:positive regulation of NIK/NF-kappaB signaling);GO:0045429(BP:positive regulation of nitric oxide biosynthetic process);GO:1903223(BP:positive regulation of oxidative stress-induced neuron death);GO:0033138(BP:positive regulation of peptidyl-serine phosphorylation);GO:0010800(BP:positive regulation of peptidyl-threonine phosphorylation);GO:0042327(BP:positive regulation of phosphorylation);GO:0032092(BP:positive regulation of protein binding);GO:1904591(BP:positive regulation of protein import);GO:0010739(BP:positive regulation of protein kinase A signaling);GO:0051897(BP:positive regulation of protein kinase B signaling);GO:0051247(BP:positive regulation of protein metabolic process);GO:0001934(BP:positive regulation of protein phosphorylation);GO:0061098(BP:positive regulation of protein tyrosine kinase activity);GO:1900122(BP:positive regulation of receptor binding);GO:1905898(BP:positive regulation of response to endoplasmic reticulum stress);GO:0032930(BP:positive regulation of superoxide anion generation);GO:2000406(BP:positive regulation of T cell migration);GO:1902949(BP:positive regulation of tau-protein kinase activity);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0042535(BP:positive regulation of tumor necrosis factor biosynthetic process);GO:0043687(BP:post-translational protein modification);GO:0051260(BP:protein homooligomerization);GO:0006468(BP:protein phosphorylation);GO:0051262(BP:protein tetramerization);GO:0070206(BP:protein trimerization);GO:1903048(BP:regulation of acetylcholine-gated cation channel activity);GO:1905906(BP:regulation of amyloid fibril formation);GO:1900221(BP:regulation of amyloid-beta clearance);GO:1902950(BP:regulation of dendritic spine maintenance);GO:0007176(BP:regulation of epidermal growth factor-activated receptor activity);GO:0010468(BP:regulation of gene expression);GO:0048169(BP:regulation of long-term neuronal synaptic plasticity);GO:0040014(BP:regulation of multicellular organism growth);GO:2000310(BP:regulation of NMDA receptor activity);GO:0050730(BP:regulation of peptidyl-tyrosine phosphorylation);GO:1905606(BP:regulation of presynapse assembly);GO:1905945(BP:regulation of response to calcium ion);GO:0150003(BP:regulation of spontaneous synaptic transmission);GO:0050803(BP:regulation of synapse structure or activity);GO:0034121(BP:regulation of toll-like receptor signaling pathway);GO:0006357(BP:regulation of transcription by RNA polymerase II);GO:0006417(BP:regulation of translation);GO:0030111(BP:regulation of Wnt signaling pathway);GO:0070555(BP:response to interleukin-1);GO:0010288(BP:response to lead ion);GO:0006979(BP:response to oxidative stress);GO:0001878(BP:response to yeast);GO:0051563(BP:smooth endoplasmic reticulum calcium ion homeostasis);GO:0001967(BP:suckling behavior);GO:0050808(BP:synapse organization);GO:0051124(BP:synaptic growth at neuromuscular junction);GO:0032640(BP:tumor necrosis factor production);GO:0008542(BP:visual learning);GO:0106003(CC:amyloid-beta complex);GO:0045177(CC:apical part of cell);GO:0097449(CC:astrocyte projection);GO:0030424(CC:axon);GO:0005623(CC:cell);GO:0009986(CC:cell surface);GO:0005911(CC:cell-cell junction);GO:0035253(CC:ciliary rootlet);GO:0005905(CC:clathrin-coated pit);GO:0030134(CC:COPII-coated ER to Golgi transport vesicle);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0043198(CC:dendritic shaft);GO:0043197(CC:dendritic spine);GO:0005769(CC:early endosome);GO:0005788(CC:endoplasmic reticulum lumen);GO:0005768(CC:endosome);GO:0031904(CC:endosome lumen);GO:0070381(CC:endosome to plasma membrane transport vesicle);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005794(CC:Golgi apparatus);GO:0005796(CC:Golgi lumen);GO:0005798(CC:Golgi-associated vesicle);GO:1990812(CC:growth cone filopodium);GO:1990761(CC:growth cone lamellipodium);GO:0034364(CC:high-density lipoprotein particle);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0034363(CC:intermediate-density lipoprotein particle);GO:1990777(CC:lipoprotein particle);GO:0044304(CC:main axon);GO:0016020(CC:membrane);GO:0045121(CC:membrane raft);GO:0005739(CC:mitochondrion);GO:0031594(CC:neuromuscular junction);GO:0005641(CC:nuclear envelope lumen);GO:0005634(CC:nucleus);GO:0043204(CC:perikaryon);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0031093(CC:platelet alpha granule lumen);GO:0048786(CC:presynaptic active zone);GO:0032991(CC:protein-containing complex);GO:0043235(CC:receptor complex);GO:0055037(CC:recycling endosome);GO:0005791(CC:rough endoplasmic reticulum);GO:0005790(CC:smooth endoplasmic reticulum);GO:0051233(CC:spindle midzone);GO:0045202(CC:synapse);GO:0008021(CC:synaptic vesicle);GO:0032588(CC:trans-Golgi network membrane);GO:0030549(MF:acetylcholine receptor activator activity);GO:0033130(MF:acetylcholine receptor binding);GO:0097645(MF:amylin binding);GO:0034185(MF:apolipoprotein binding);GO:0051087(MF:chaperone binding);GO:0042056(MF:chemoattractant activity);GO:0003677(MF:DNA binding);GO:0019899(MF:enzyme binding);GO:0046875(MF:ephrin receptor binding);GO:0005109(MF:frizzled binding);GO:0001664(MF:G-protein coupled receptor binding);GO:0070851(MF:growth factor receptor binding);GO:1904399(MF:heparan sulfate binding);GO:0043395(MF:heparan sulfate proteoglycan binding);GO:0008201(MF:heparin binding);GO:0042802(MF:identical protein binding);GO:0005158(MF:insulin receptor binding);GO:0005178(MF:integrin binding);GO:0050750(MF:low-density lipoprotein particle receptor binding);GO:0016504(MF:peptidase activator activity);GO:0046983(MF:protein dimerization activity);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity);GO:0051425(MF:PTB domain binding);GO:0050786(MF:RAGE receptor binding);GO:0030546(MF:receptor activator activity);GO:0000979(MF:RNA polymerase II core promoter sequence-specific DNA binding);GO:0004867(MF:serine-type endopeptidase inhibitor activity);GO:0005102(MF:signaling receptor binding);GO:0046914(MF:transition metal ion binding)	hsa05010(Alzheimer disease);hsa04726(Serotonergic synapse)
Q9NU53	2.077156	0.009640883	Glycoprotein integral membrane protein 1	116254	GINM1	GO:0016021(CC:integral component of membrane)	-
Q8NFL0	2.061774	0.018910803	"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7"	93010	B3GNT7	"GO:0018146(BP:keratan sulfate biosynthetic process);GO:0016266(BP:O-glycan processing);GO:0030311(BP:poly-N-acetyllactosamine biosynthetic process);GO:0006486(BP:protein glycosylation);GO:0005783(CC:endoplasmic reticulum);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane);GO:0008376(MF:acetylgalactosaminyltransferase activity);GO:0008378(MF:galactosyltransferase activity);GO:0008532(MF:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity)"	hsa00533(Glycosaminoglycan biosynthesis - keratan sulfate)
Q9BXS4	2.05897	0.01094219	Transmembrane protein 59	9528	TMEM59	GO:0006914(BP:autophagy);GO:0090285(BP:negative regulation of protein glycosylation in Golgi);GO:1903077(BP:negative regulation of protein localization to plasma membrane);GO:0010955(BP:negative regulation of protein processing);GO:0010508(BP:positive regulation of autophagy);GO:0070062(CC:extracellular exosome);GO:0000137(CC:Golgi cis cisterna);GO:0005797(CC:Golgi medial cisterna);GO:0000139(CC:Golgi membrane);GO:0000138(CC:Golgi trans cisterna);GO:0016021(CC:integral component of membrane);GO:0005770(CC:late endosome);GO:0031902(CC:late endosome membrane);GO:0005765(CC:lysosomal membrane);GO:0005764(CC:lysosome);GO:0005886(CC:plasma membrane);GO:0004175(MF:endopeptidase activity)	-
Q06481	2.035743	0.000180455	Amyloid-like protein 2	334	APLP2	GO:0044267(BP:cellular protein metabolic process);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0002576(BP:platelet degranulation);GO:0043687(BP:post-translational protein modification);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0031092(CC:platelet alpha granule membrane);GO:0003677(MF:DNA binding);GO:0008201(MF:heparin binding);GO:0042802(MF:identical protein binding);GO:0004867(MF:serine-type endopeptidase inhibitor activity);GO:0046914(MF:transition metal ion binding)	-
Q13501	2.031098	0.000532401	Sequestosome-1	8878	SQSTM1	GO:0035973(BP:aggrephagy);GO:0006915(BP:apoptotic process);GO:0006914(BP:autophagy);GO:0000422(BP:autophagy of mitochondrion);GO:0030154(BP:cell differentiation);GO:0016197(BP:endosomal transport);GO:0007032(BP:endosome organization);GO:0002376(BP:immune system process);GO:0070498(BP:interleukin-1-mediated signaling pathway);GO:0035556(BP:intracellular signal transduction);GO:0016236(BP:macroautophagy);GO:0007005(BP:mitochondrion organization);GO:0000423(BP:mitophagy);GO:0043066(BP:negative regulation of apoptotic process);GO:0044130(BP:negative regulation of growth of symbiont in host);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0043065(BP:positive regulation of apoptotic process);GO:1900273(BP:positive regulation of long-term synaptic potentiation);GO:1903078(BP:positive regulation of protein localization to plasma membrane);GO:0001934(BP:positive regulation of protein phosphorylation);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0051291(BP:protein heterooligomerization);GO:0008104(BP:protein localization);GO:1905719(BP:protein localization to perinuclear region of cytoplasm);GO:0043122(BP:regulation of I-kappaB kinase/NF-kappaB signaling);GO:0010821(BP:regulation of mitochondrion organization);GO:0061635(BP:regulation of protein complex stability);GO:0046578(BP:regulation of Ras protein signal transduction);GO:0002931(BP:response to ischemia);GO:0098780(BP:response to mitochondrial depolarisation);GO:0061912(BP:selective autophagy);GO:0006511(BP:ubiquitin-dependent protein catabolic process);GO:0016235(CC:aggresome);GO:0044753(CC:amphisome);GO:0044754(CC:autolysosome);GO:0005776(CC:autophagosome);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0016234(CC:inclusion body);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005770(CC:late endosome);GO:0097413(CC:Lewy body);GO:0005739(CC:mitochondrion);GO:0005654(CC:nucleoplasm);GO:0000932(CC:P-body);GO:0000407(CC:phagophore assembly site);GO:0016605(CC:PML body);GO:0030017(CC:sarcomere);GO:0097225(CC:sperm midpiece);GO:0019899(MF:enzyme binding);GO:0042802(MF:identical protein binding);GO:0035255(MF:ionotropic glutamate receptor binding);GO:0070530(MF:K63-linked polyubiquitin modification-dependent protein binding);GO:0042803(MF:protein homodimerization activity);GO:0019901(MF:protein kinase binding);GO:0005080(MF:protein kinase C binding);GO:0004674(MF:protein serine/threonine kinase activity);GO:0030971(MF:receptor tyrosine kinase binding);GO:0042169(MF:SH2 domain binding);GO:0043130(MF:ubiquitin binding);GO:0031625(MF:ubiquitin protein ligase binding);GO:0008270(MF:zinc ion binding)	hsa04137(Mitophagy - animal);hsa04217(Necroptosis);hsa04380(Osteoclast differentiation);hsa05418(Fluid shear stress and atherosclerosis);hsa04218(Cellular senescence)
P12259	1.961971	0.001052202	Coagulation factor V	2153	F5	GO:0008015(BP:blood circulation);GO:0007596(BP:blood coagulation);GO:0044267(BP:cellular protein metabolic process);GO:0048208(BP:COPII vesicle coating);GO:0006888(BP:ER to Golgi vesicle-mediated transport);GO:0002576(BP:platelet degranulation);GO:0043687(BP:post-translational protein modification);GO:0030134(CC:COPII-coated ER to Golgi transport vesicle);GO:0005788(CC:endoplasmic reticulum lumen);GO:0033116(CC:endoplasmic reticulum-Golgi intermediate compartment membrane);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1903561(CC:extracellular vesicle);GO:0000139(CC:Golgi membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0031093(CC:platelet alpha granule lumen);GO:0005507(MF:copper ion binding)	hsa04610(Complement and coagulation cascades)
P02749	1.938979	0.010975889	Beta-2-glycoprotein 1	350	APOH	"GO:0007597(BP:blood coagulation, intrinsic pathway);GO:0016525(BP:negative regulation of angiogenesis);GO:0030195(BP:negative regulation of blood coagulation);GO:0010596(BP:negative regulation of endothelial cell migration);GO:0001937(BP:negative regulation of endothelial cell proliferation);GO:0051918(BP:negative regulation of fibrinolysis);GO:0033033(BP:negative regulation of myeloid cell apoptotic process);GO:0034392(BP:negative regulation of smooth muscle cell apoptotic process);GO:0031639(BP:plasminogen activation);GO:0002576(BP:platelet degranulation);GO:0030194(BP:positive regulation of blood coagulation);GO:0051006(BP:positive regulation of lipoprotein lipase activity);GO:0051917(BP:regulation of fibrinolysis);GO:0006641(BP:triglyceride metabolic process);GO:0034197(BP:triglyceride transport);GO:0009986(CC:cell surface);GO:0042627(CC:chylomicron);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0034364(CC:high-density lipoprotein particle);GO:0031089(CC:platelet dense granule lumen);GO:0034361(CC:very-low-density lipoprotein particle);GO:0008201(MF:heparin binding);GO:0042802(MF:identical protein binding);GO:0008289(MF:lipid binding);GO:0060230(MF:lipoprotein lipase activator activity);GO:0005543(MF:phospholipid binding)"	hsa04979(Cholesterol metabolism)
Q15493	1.932304	0.002172311	Regucalcin	9104	RGN	GO:0007568(BP:aging);GO:0006874(BP:cellular calcium ion homeostasis);GO:0001822(BP:kidney development);GO:0019853(BP:L-ascorbic acid biosynthetic process);GO:0097421(BP:liver regeneration);GO:0043066(BP:negative regulation of apoptotic process);GO:1903011(BP:negative regulation of bone development);GO:1903611(BP:negative regulation of calcium-dependent ATPase activity);GO:0051344(BP:negative regulation of cyclic-nucleotide phosphodiesterase activity);GO:2000279(BP:negative regulation of DNA biosynthetic process);GO:1903625(BP:negative regulation of DNA catabolic process);GO:0050680(BP:negative regulation of epithelial cell proliferation);GO:1901318(BP:negative regulation of flagellated sperm motility);GO:0034260(BP:negative regulation of GTPase activity);GO:1903634(BP:negative regulation of leucine-tRNA ligase activity);GO:0045019(BP:negative regulation of nitric oxide biosynthetic process);GO:0032515(BP:negative regulation of phosphoprotein phosphatase activity);GO:0006469(BP:negative regulation of protein kinase activity);GO:1902679(BP:negative regulation of RNA biosynthetic process);GO:0032781(BP:positive regulation of ATPase activity);GO:1901896(BP:positive regulation of calcium-transporting ATPase activity);GO:1903629(BP:positive regulation of dUTP diphosphatase activity);GO:0045723(BP:positive regulation of fatty acid biosynthetic process);GO:0010907(BP:positive regulation of glucose metabolic process);GO:0043547(BP:positive regulation of GTPase activity);GO:0010922(BP:positive regulation of phosphatase activity);GO:1903052(BP:positive regulation of proteolysis involved in cellular protein catabolic process);GO:1901671(BP:positive regulation of superoxide dismutase activity);GO:0010867(BP:positive regulation of triglyceride biosynthetic process);GO:0050848(BP:regulation of calcium-mediated signaling);GO:0007283(BP:spermatogenesis);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005634(CC:nucleus);GO:0005509(MF:calcium ion binding);GO:0030234(MF:enzyme regulator activity);GO:0004341(MF:gluconolactonase activity);GO:0008270(MF:zinc ion binding)	hsa00053(Ascorbate and aldarate metabolism);hsa00030(Pentose phosphate pathway)
P01130	1.926464	0.004384545	Low-density lipoprotein receptor	3949	LDLR	GO:0097242(BP:amyloid-beta clearance);GO:0048844(BP:artery morphogenesis);GO:0071398(BP:cellular response to fatty acid);GO:0071404(BP:cellular response to low-density lipoprotein particle stimulus);GO:0042632(BP:cholesterol homeostasis);GO:0070508(BP:cholesterol import);GO:0008203(BP:cholesterol metabolic process);GO:0030301(BP:cholesterol transport);GO:0034382(BP:chylomicron remnant clearance);GO:0006897(BP:endocytosis);GO:0034384(BP:high-density lipoprotein particle clearance);GO:0030299(BP:intestinal cholesterol absorption);GO:0006629(BP:lipid metabolic process);GO:0042159(BP:lipoprotein catabolic process);GO:0007616(BP:long-term memory);GO:0034383(BP:low-density lipoprotein particle clearance);GO:0061024(BP:membrane organization);GO:1905907(BP:negative regulation of amyloid fibril formation);GO:0061889(BP:negative regulation of astrocyte activation);GO:0010629(BP:negative regulation of gene expression);GO:1903979(BP:negative regulation of microglial cell activation);GO:0051248(BP:negative regulation of protein metabolic process);GO:0006909(BP:phagocytosis);GO:0015914(BP:phospholipid transport);GO:0034381(BP:plasma lipoprotein particle clearance);GO:0010628(BP:positive regulation of gene expression);GO:0050729(BP:positive regulation of inflammatory response);GO:1905167(BP:positive regulation of lysosomal protein catabolic process);GO:0010867(BP:positive regulation of triglyceride biosynthetic process);GO:0006898(BP:receptor-mediated endocytosis);GO:0090118(BP:receptor-mediated endocytosis involved in cholesterol transport);GO:0090181(BP:regulation of cholesterol metabolic process);GO:0010899(BP:regulation of phosphatidylcholine catabolic process);GO:0051246(BP:regulation of protein metabolic process);GO:0061771(BP:response to caloric restriction);GO:0045177(CC:apical part of cell);GO:0016323(CC:basolateral plasma membrane);GO:0005623(CC:cell);GO:0009986(CC:cell surface);GO:0030669(CC:clathrin-coated endocytic vesicle membrane);GO:0005905(CC:clathrin-coated pit);GO:0005769(CC:early endosome);GO:0036020(CC:endolysosome membrane);GO:0010008(CC:endosome membrane);GO:0009897(CC:external side of plasma membrane);GO:0005794(CC:Golgi apparatus);GO:0005887(CC:integral component of plasma membrane);GO:0005770(CC:late endosome);GO:0034362(CC:low-density lipoprotein particle);GO:0005764(CC:lysosome);GO:0016020(CC:membrane);GO:1990666(CC:PCSK9-LDLR complex);GO:0005886(CC:plasma membrane);GO:0043235(CC:receptor complex);GO:0036477(CC:somatodendritic compartment);GO:0097443(CC:sorting endosome);GO:0001540(MF:amyloid-beta binding);GO:0005509(MF:calcium ion binding);GO:0032050(MF:clathrin heavy chain binding);GO:0042802(MF:identical protein binding);GO:0030169(MF:low-density lipoprotein particle binding);GO:0005041(MF:low-density lipoprotein particle receptor activity);GO:0002020(MF:protease binding);GO:0030229(MF:very-low-density lipoprotein particle receptor activity);GO:0001618(MF:virus receptor activity)	hsa04979(Cholesterol metabolism);hsa04913(Ovarian steroidogenesis);hsa04934(Cushing syndrome);hsa05160(Hepatitis C);hsa04144(Endocytosis);hsa04925(Aldosterone synthesis and secretion);hsa04927(Cortisol synthesis and secretion);hsa05145(Toxoplasmosis);hsa04976(Bile secretion)
P00747	1.924963	0.000927533	Plasminogen	5340	PLG	GO:0007596(BP:blood coagulation);GO:0044267(BP:cellular protein metabolic process);GO:0022617(BP:extracellular matrix disassembly);GO:0042730(BP:fibrinolysis);GO:0051702(BP:interaction with symbiont);GO:0052213(BP:interaction with symbiont via secreted substance involved in symbiotic interaction);GO:0052182(BP:modification by host of symbiont morphology or physiology via secreted substance);GO:0008285(BP:negative regulation of cell proliferation);GO:2000048(BP:negative regulation of cell-cell adhesion mediated by cadherin);GO:0010812(BP:negative regulation of cell-substrate adhesion);GO:0051918(BP:negative regulation of fibrinolysis);GO:0002576(BP:platelet degranulation);GO:0043536(BP:positive regulation of blood vessel endothelial cell migration);GO:0051919(BP:positive regulation of fibrinolysis);GO:0006508(BP:proteolysis);GO:0048771(BP:tissue remodeling);GO:0072562(CC:blood microparticle);GO:0009986(CC:cell surface);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0031232(CC:extrinsic component of external side of plasma membrane);GO:0044218(CC:other organism cell membrane);GO:0005886(CC:plasma membrane);GO:0031093(CC:platelet alpha granule lumen);GO:0034185(MF:apolipoprotein binding);GO:0051087(MF:chaperone binding);GO:0004175(MF:endopeptidase activity);GO:0019899(MF:enzyme binding);GO:0019900(MF:kinase binding);GO:1904854(MF:proteasome core complex binding);GO:1990405(MF:protein antigen binding);GO:0019904(MF:protein domain specific binding);GO:0004252(MF:serine-type endopeptidase activity);GO:0008236(MF:serine-type peptidase activity);GO:0005102(MF:signaling receptor binding)	hsa05164(Influenza A);hsa05150(Staphylococcus aureus infection);hsa04610(Complement and coagulation cascades);hsa04080(Neuroactive ligand-receptor interaction)
Q16270	1.908678	0.001115612	Insulin-like growth factor-binding protein 7	3490	IGFBP7	GO:0007155(BP:cell adhesion);GO:0044267(BP:cellular protein metabolic process);GO:0032870(BP:cellular response to hormone stimulus);GO:0007566(BP:embryo implantation);GO:0008285(BP:negative regulation of cell proliferation);GO:0043687(BP:post-translational protein modification);GO:0001558(BP:regulation of cell growth);GO:0050810(BP:regulation of steroid biosynthetic process);GO:0051414(BP:response to cortisol);GO:0009408(BP:response to heat);GO:0032526(BP:response to retinoic acid);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005201(MF:extracellular matrix structural constituent);GO:0005520(MF:insulin-like growth factor binding)	-
P29279	1.897597	0.004123303	Connective tissue growth factor	1490	CTGF	GO:0007568(BP:aging);GO:0001525(BP:angiogenesis);GO:0001502(BP:cartilage condensation);GO:0007155(BP:cell adhesion);GO:0030154(BP:cell differentiation);GO:0016477(BP:cell migration);GO:0007160(BP:cell-matrix adhesion);GO:0035988(BP:chondrocyte proliferation);GO:0060401(BP:cytosolic calcium ion transport);GO:0071897(BP:DNA biosynthetic process);GO:0008544(BP:epidermis development);GO:0070278(BP:extracellular matrix constituent secretion);GO:0008543(BP:fibroblast growth factor receptor signaling pathway);GO:0007229(BP:integrin-mediated signaling pathway);GO:0035556(BP:intracellular signal transduction);GO:0030324(BP:lung development);GO:0060548(BP:negative regulation of cell death);GO:0010629(BP:negative regulation of gene expression);GO:0001503(BP:ossification);GO:0060452(BP:positive regulation of cardiac muscle contraction);GO:0050867(BP:positive regulation of cell activation);GO:0045597(BP:positive regulation of cell differentiation);GO:0008284(BP:positive regulation of cell proliferation);GO:0032967(BP:positive regulation of collagen biosynthetic process);GO:0043280(BP:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:0070318(BP:positive regulation of G0 to G1 transition);GO:0010628(BP:positive regulation of gene expression);GO:0046330(BP:positive regulation of JNK cascade);GO:0051496(BP:positive regulation of stress fiber assembly);GO:0072593(BP:reactive oxygen species metabolic process);GO:0032330(BP:regulation of chondrocyte differentiation);GO:0043200(BP:response to amino acid);GO:0034059(BP:response to anoxia);GO:0032355(BP:response to estradiol);GO:0070542(BP:response to fatty acid);GO:0009749(BP:response to glucose);GO:0051385(BP:response to mineralocorticoid);GO:0043434(BP:response to peptide hormone);GO:0009611(BP:response to wounding);GO:0001894(BP:tissue homeostasis);GO:0006367(BP:transcription initiation from RNA polymerase II promoter);GO:0005938(CC:cell cortex);GO:0005801(CC:cis-Golgi network);GO:0005829(CC:cytosol);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0001968(MF:fibronectin binding);GO:0008083(MF:growth factor activity);GO:0008201(MF:heparin binding);GO:0005520(MF:insulin-like growth factor binding);GO:0005178(MF:integrin binding);GO:0008022(MF:protein C-terminus binding)	hsa04390(Hippo signaling pathway);hsa04371(Apelin signaling pathway)
O14495	1.883967	0.016629183	Phospholipid phosphatase 3	8613	PLPP3	GO:0060070(BP:canonical Wnt signaling pathway);GO:0044329(BP:canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion);GO:0044328(BP:canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration);GO:0044330(BP:canonical Wnt signaling pathway involved in positive regulation of wound healing);GO:0008354(BP:germ cell migration);GO:0034109(BP:homotypic cell-cell adhesion);GO:0006629(BP:lipid metabolic process);GO:0001933(BP:negative regulation of protein phosphorylation);GO:0046839(BP:phospholipid dephosphorylation);GO:0006644(BP:phospholipid metabolic process);GO:0051091(BP:positive regulation of DNA binding transcription factor activity);GO:0050821(BP:protein stabilization);GO:0030111(BP:regulation of Wnt signaling pathway);GO:0030148(BP:sphingolipid biosynthetic process);GO:0005912(CC:adherens junction);GO:0005794(CC:Golgi apparatus);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0042577(MF:lipid phosphatase activity);GO:0016791(MF:phosphatase activity);GO:0008195(MF:phosphatidate phosphatase activity);GO:0004721(MF:phosphoprotein phosphatase activity);GO:0042392(MF:sphingosine-1-phosphate phosphatase activity)	hsa00564(Glycerophospholipid metabolism);hsa04072(Phospholipase D signaling pathway);hsa05231(Choline metabolism in cancer);hsa04975(Fat digestion and absorption);hsa00561(Glycerolipid metabolism);hsa00600(Sphingolipid metabolism);hsa04666(Fc gamma R-mediated phagocytosis);hsa00565(Ether lipid metabolism)
P00749	1.844437	0.000125034	Urokinase-type plasminogen activator	5328	PLAU	GO:0007596(BP:blood coagulation);GO:0006935(BP:chemotaxis);GO:0042730(BP:fibrinolysis);GO:0043312(BP:neutrophil degranulation);GO:0031639(BP:plasminogen activation);GO:0030335(BP:positive regulation of cell migration);GO:0006508(BP:proteolysis);GO:0033628(BP:regulation of cell adhesion mediated by integrin);GO:0042127(BP:regulation of cell proliferation);GO:0010469(BP:regulation of signaling receptor activity);GO:0014910(BP:regulation of smooth muscle cell migration);GO:2000097(BP:regulation of smooth muscle cell-matrix adhesion);GO:0061041(BP:regulation of wound healing);GO:0001666(BP:response to hypoxia);GO:0007165(BP:signal transduction);GO:0014909(BP:smooth muscle cell migration);GO:0009986(CC:cell surface);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005925(CC:focal adhesion);GO:0005886(CC:plasma membrane);GO:0035579(CC:specific granule membrane);GO:0070821(CC:tertiary granule membrane);GO:0004252(MF:serine-type endopeptidase activity)	hsa04610(Complement and coagulation cascades);hsa05215(Prostate cancer);hsa05205(Proteoglycans in cancer);hsa05206(MicroRNAs in cancer);hsa05202(Transcriptional misregulation in cancer);hsa04064(NF-kappa B signaling pathway)
P51511	1.841716	0.001401368	Matrix metalloproteinase-15	4324	MMP15	GO:0006464(BP:cellular protein modification process);GO:0030574(BP:collagen catabolic process);GO:0035987(BP:endodermal cell differentiation);GO:0022617(BP:extracellular matrix disassembly);GO:0030198(BP:extracellular matrix organization);GO:0006508(BP:proteolysis);GO:0032355(BP:response to estradiol);GO:0031012(CC:extracellular matrix);GO:0005615(CC:extracellular space);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0008047(MF:enzyme activator activity);GO:0070006(MF:metalloaminopeptidase activity);GO:0004222(MF:metalloendopeptidase activity);GO:0008270(MF:zinc ion binding)	"hsa04928(Parathyroid hormone synthesis, secretion and action)"
P10124	1.82241	0.048587323	Serglycin	5552	SRGN	GO:0031214(BP:biomineral tissue development);GO:0008626(BP:granzyme-mediated apoptotic signaling pathway);GO:0033382(BP:maintenance of granzyme B location in T cell secretory granule);GO:0033373(BP:maintenance of protease location in mast cell secretory granule);GO:0033364(BP:mast cell secretory granule organization);GO:0030502(BP:negative regulation of bone mineralization);GO:0050710(BP:negative regulation of cytokine secretion);GO:0002576(BP:platelet degranulation);GO:0016485(BP:protein processing);GO:0033371(BP:T cell secretory granule organization);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005794(CC:Golgi apparatus);GO:0042629(CC:mast cell granule);GO:0031093(CC:platelet alpha granule lumen)	-
P55085	1.809964	0.004400469	Proteinase-activated receptor 2	2150	F2RL1	"GO:0007596(BP:blood coagulation);GO:0045217(BP:cell-cell junction maintenance);GO:0035926(BP:chemokine (C-C motif) ligand 2 secretion);GO:0090195(BP:chemokine secretion);GO:0051607(BP:defense response to virus);GO:0061028(BP:establishment of endothelial barrier);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0006954(BP:inflammatory response);GO:0045087(BP:innate immune response);GO:0072643(BP:interferon-gamma secretion);GO:0050702(BP:interleukin-1 beta secretion);GO:0072608(BP:interleukin-10 secretion);GO:0050900(BP:leukocyte migration);GO:0070661(BP:leukocyte proliferation);GO:0097029(BP:mature conventional dendritic cell differentiation);GO:0090198(BP:negative regulation of chemokine secretion);GO:0046329(BP:negative regulation of JNK cascade);GO:0034140(BP:negative regulation of toll-like receptor 3 signaling pathway);GO:0010804(BP:negative regulation of tumor necrosis factor-mediated signaling pathway);GO:0042119(BP:neutrophil activation);GO:0030836(BP:positive regulation of actin filament depolymerization);GO:0097755(BP:positive regulation of blood vessel diameter);GO:0030335(BP:positive regulation of cell migration);GO:0050921(BP:positive regulation of chemotaxis);GO:0002741(BP:positive regulation of cytokine secretion involved in immune response);GO:0007204(BP:positive regulation of cytosolic calcium ion concentration);GO:0051482(BP:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway);GO:0043311(BP:positive regulation of eosinophil degranulation);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:0003104(BP:positive regulation of glomerular filtration);GO:0043547(BP:positive regulation of GTPase activity);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:2000778(BP:positive regulation of interleukin-6 secretion);GO:2000484(BP:positive regulation of interleukin-8 secretion);GO:0046330(BP:positive regulation of JNK cascade);GO:0002690(BP:positive regulation of leukocyte chemotaxis);GO:0070963(BP:positive regulation of neutrophil mediated killing of gram-negative bacterium);GO:0060100(BP:positive regulation of phagocytosis, engulfment);GO:0014068(BP:positive regulation of phosphatidylinositol 3-kinase signaling);GO:0050927(BP:positive regulation of positive chemotaxis);GO:0031274(BP:positive regulation of pseudopodium assembly);GO:1900135(BP:positive regulation of renin secretion into blood stream);GO:0035025(BP:positive regulation of Rho protein signal transduction);GO:0032930(BP:positive regulation of superoxide anion generation);GO:0034137(BP:positive regulation of toll-like receptor 2 signaling pathway);GO:0034141(BP:positive regulation of toll-like receptor 3 signaling pathway);GO:0034145(BP:positive regulation of toll-like receptor 4 signaling pathway);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0030193(BP:regulation of blood coagulation);GO:0043122(BP:regulation of I-kappaB kinase/NF-kappaB signaling);GO:0046328(BP:regulation of JNK cascade);GO:0002286(BP:T cell activation involved in immune response);GO:0005769(CC:early endosome);GO:0005794(CC:Golgi apparatus);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0031143(CC:pseudopodium);GO:0004930(MF:G-protein coupled receptor activity);GO:0001965(MF:G-protein alpha-subunit binding);GO:0031681(MF:G-protein beta-subunit binding);GO:0038023(MF:signaling receptor activity);GO:0005102(MF:signaling receptor binding);GO:0015057(MF:thrombin-activated receptor activity)"	hsa05143(African trypanosomiasis);hsa04080(Neuroactive ligand-receptor interaction);hsa04750(Inflammatory mediator regulation of TRP channels)
Q01581	1.805273	0.002345363	"Hydroxymethylglutaryl-CoA synthase, cytoplasmic"	3157	HMGCS1	"GO:0006084(BP:acetyl-CoA metabolic process);GO:0007420(BP:brain development);GO:0071397(BP:cellular response to cholesterol);GO:0071372(BP:cellular response to follicle-stimulating hormone stimulus);GO:0071404(BP:cellular response to low-density lipoprotein particle stimulus);GO:0006695(BP:cholesterol biosynthetic process);GO:0010142(BP:farnesyl diphosphate biosynthetic process, mevalonate pathway);GO:0006629(BP:lipid metabolic process);GO:0001889(BP:liver development);GO:0008584(BP:male gonad development);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0019216(BP:regulation of lipid metabolic process);GO:0042493(BP:response to drug);GO:0009645(BP:response to low light intensity stimulus);GO:0014074(BP:response to purine-containing compound);GO:0046690(BP:response to tellurium ion);GO:0033197(BP:response to vitamin E);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0008144(MF:drug binding);GO:0004421(MF:hydroxymethylglutaryl-CoA synthase activity);GO:0016853(MF:isomerase activity);GO:0043177(MF:organic acid binding);GO:0042803(MF:protein homodimerization activity)"	"hsa00650(Butanoate metabolism);hsa00280(Valine, leucine and isoleucine degradation);hsa00072(Synthesis and degradation of ketone bodies);hsa00900(Terpenoid backbone biosynthesis)"
P02458	1.7724	0.004247437	Collagen alpha-1(II) chain	1280	COL2A1	GO:0097065(BP:anterior head development);GO:0001502(BP:cartilage condensation);GO:0051216(BP:cartilage development);GO:0060351(BP:cartilage development involved in endochondral bone morphogenesis);GO:0071773(BP:cellular response to BMP stimulus);GO:0007417(BP:central nervous system development);GO:0002062(BP:chondrocyte differentiation);GO:0030199(BP:collagen fibril organization);GO:0060272(BP:embryonic skeletal joint morphogenesis);GO:0001958(BP:endochondral ossification);GO:0030198(BP:extracellular matrix organization);GO:0003007(BP:heart morphogenesis);GO:0042472(BP:inner ear morphogenesis);GO:0060174(BP:limb bud formation);GO:2001240(BP:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand);GO:0030903(BP:notochord development);GO:0071599(BP:otic vesicle development);GO:0006029(BP:proteoglycan metabolic process);GO:0010468(BP:regulation of gene expression);GO:0050776(BP:regulation of immune response);GO:0060021(BP:roof of mouth development);GO:0007605(BP:sensory perception of sound);GO:0001501(BP:skeletal system development);GO:0001894(BP:tissue homeostasis);GO:0007601(BP:visual perception);GO:0005604(CC:basement membrane);GO:0005581(CC:collagen trimer);GO:0005585(CC:collagen type II trimer);GO:0005788(CC:endoplasmic reticulum lumen);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005201(MF:extracellular matrix structural constituent);GO:0030020(MF:extracellular matrix structural constituent conferring tensile strength);GO:0042802(MF:identical protein binding);GO:0046872(MF:metal ion binding);GO:0042289(MF:MHC class II protein binding);GO:0048407(MF:platelet-derived growth factor binding);GO:0043394(MF:proteoglycan binding)	hsa04151(PI3K-Akt signaling pathway);hsa04510(Focal adhesion);hsa04512(ECM-receptor interaction);hsa05165(Human papillomavirus infection);hsa04974(Protein digestion and absorption)
Q9Y653	1.763697	0.003741373	Adhesion G-protein coupled receptor G1	9289	ADGRG1	GO:0007189(BP:adenylate cyclase-activating G-protein coupled receptor signaling pathway);GO:0001525(BP:angiogenesis);GO:0007420(BP:brain development);GO:0007155(BP:cell adhesion);GO:0016477(BP:cell migration);GO:0007166(BP:cell surface receptor signaling pathway);GO:0007267(BP:cell-cell signaling);GO:0021801(BP:cerebral cortex radial glia guided migration);GO:0021796(BP:cerebral cortex regionalization);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0021819(BP:layer formation in cerebral cortex);GO:0008285(BP:negative regulation of cell proliferation);GO:2001223(BP:negative regulation of neuron migration);GO:0045785(BP:positive regulation of cell adhesion);GO:2000179(BP:positive regulation of neural precursor cell proliferation);GO:0035025(BP:positive regulation of Rho protein signal transduction);GO:0070528(BP:protein kinase C signaling);GO:0007266(BP:Rho protein signal transduction);GO:0072520(BP:seminiferous tubule development);GO:0010573(BP:vascular endothelial growth factor production);GO:0070062(CC:extracellular exosome);GO:0097451(CC:glial limiting end-foot);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0045121(CC:membrane raft);GO:0005518(MF:collagen binding);GO:0050840(MF:extracellular matrix binding);GO:0004930(MF:G-protein coupled receptor activity);GO:0008201(MF:heparin binding)	-
Q08431	1.736575	0.006149621	Lactadherin	4240	MFGE8	"GO:0001525(BP:angiogenesis);GO:0043277(BP:apoptotic cell clearance);GO:0007155(BP:cell adhesion);GO:0044267(BP:cellular protein metabolic process);GO:0006911(BP:phagocytosis, engulfment);GO:0006910(BP:phagocytosis, recognition);GO:0050766(BP:positive regulation of phagocytosis);GO:0043687(BP:post-translational protein modification);GO:0007338(BP:single fertilization);GO:0005788(CC:endoplasmic reticulum lumen);GO:0009897(CC:external side of plasma membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1903561(CC:extracellular vesicle);GO:0019897(CC:extrinsic component of plasma membrane);GO:0016020(CC:membrane);GO:0005201(MF:extracellular matrix structural constituent);GO:0005178(MF:integrin binding);GO:0008429(MF:phosphatidylethanolamine binding);GO:0001786(MF:phosphatidylserine binding)"	-
Q14520	1.735485	0.0138614	Hyaluronan-binding protein 2	3026	HABP2	GO:0007155(BP:cell adhesion);GO:0006508(BP:proteolysis);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005509(MF:calcium ion binding);GO:0005539(MF:glycosaminoglycan binding);GO:0004252(MF:serine-type endopeptidase activity)	-
Q9NZV1	1.726893	0.008554158	Cysteine-rich motor neuron 1 protein	51232	CRIM1	GO:0007399(BP:nervous system development);GO:0005576(CC:extracellular region);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0005520(MF:insulin-like growth factor binding);GO:0005010(MF:insulin-like growth factor-activated receptor activity);GO:0030165(MF:PDZ domain binding);GO:0004867(MF:serine-type endopeptidase inhibitor activity)	-
P07093	1.723915	0.002315203	Glia-derived nexin	5270	SERPINE2	"GO:0007596(BP:blood coagulation);GO:0021683(BP:cerebellar granular layer morphogenesis);GO:0050974(BP:detection of mechanical stimulus involved in sensory perception);GO:0060384(BP:innervation);GO:0060291(BP:long-term synaptic potentiation);GO:0042628(BP:mating plug formation);GO:0030195(BP:negative regulation of blood coagulation);GO:0030308(BP:negative regulation of cell growth);GO:0008285(BP:negative regulation of cell proliferation);GO:0010951(BP:negative regulation of endopeptidase activity);GO:0014067(BP:negative regulation of phosphatidylinositol 3-kinase signaling);GO:0010757(BP:negative regulation of plasminogen activation);GO:0090331(BP:negative regulation of platelet aggregation);GO:0042177(BP:negative regulation of protein catabolic process);GO:0010955(BP:negative regulation of protein processing);GO:0045861(BP:negative regulation of proteolysis);GO:0045879(BP:negative regulation of smoothened signaling pathway);GO:0010766(BP:negative regulation of sodium ion transport);GO:0048711(BP:positive regulation of astrocyte differentiation);GO:0030334(BP:regulation of cell migration);GO:0051966(BP:regulation of synaptic transmission, glutamatergic);GO:0048505(BP:regulation of timing of cell differentiation);GO:0032940(BP:secretion by cell);GO:0033363(BP:secretory granule organization);GO:0061108(BP:seminal vesicle epithelium development);GO:0005829(CC:cytosol);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1903561(CC:extracellular vesicle);GO:0031232(CC:extrinsic component of external side of plasma membrane);GO:0031594(CC:neuromuscular junction);GO:0031091(CC:platelet alpha granule);GO:0005539(MF:glycosaminoglycan binding);GO:0008201(MF:heparin binding);GO:0004867(MF:serine-type endopeptidase inhibitor activity);GO:0005102(MF:signaling receptor binding)"	-
Q03405	1.721314	5.93E-06	Urokinase plasminogen activator surface receptor	5329	PLAUR	GO:0007596(BP:blood coagulation);GO:0006935(BP:chemotaxis);GO:0042730(BP:fibrinolysis);GO:0043066(BP:negative regulation of apoptotic process);GO:2001268(BP:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway);GO:2001243(BP:negative regulation of intrinsic apoptotic signaling pathway);GO:0043312(BP:neutrophil degranulation);GO:0043388(BP:positive regulation of DNA binding);GO:0045742(BP:positive regulation of epidermal growth factor receptor signaling pathway);GO:0001934(BP:positive regulation of protein phosphorylation);GO:0090200(BP:positive regulation of release of cytochrome c from mitochondria);GO:0030162(BP:regulation of proteolysis);GO:0007165(BP:signal transduction);GO:0031225(CC:anchored component of membrane);GO:0009986(CC:cell surface);GO:0005788(CC:endoplasmic reticulum lumen);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005576(CC:extracellular region);GO:0019898(CC:extrinsic component of membrane);GO:0005925(CC:focal adhesion);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0071438(CC:invadopodium membrane);GO:0005886(CC:plasma membrane);GO:0035579(CC:specific granule membrane);GO:0019899(MF:enzyme binding);GO:0019904(MF:protein domain specific binding);GO:0038023(MF:signaling receptor activity);GO:0005102(MF:signaling receptor binding);GO:0030377(MF:urokinase plasminogen activator receptor activity)	hsa04610(Complement and coagulation cascades);hsa05205(Proteoglycans in cancer)
P16035	1.710483	4.97E-05	Metalloproteinase inhibitor 2	7077	TIMP2	GO:0007568(BP:aging);GO:0007417(BP:central nervous system development);GO:0022617(BP:extracellular matrix disassembly);GO:0008285(BP:negative regulation of cell proliferation);GO:0010951(BP:negative regulation of endopeptidase activity);GO:0051045(BP:negative regulation of membrane protein ectodomain proteolysis);GO:1905049(BP:negative regulation of metallopeptidase activity);GO:0045930(BP:negative regulation of mitotic cell cycle);GO:0046580(BP:negative regulation of Ras protein signal transduction);GO:0043312(BP:neutrophil degranulation);GO:0045762(BP:positive regulation of adenylate cyclase activity);GO:0043410(BP:positive regulation of MAPK cascade);GO:0045666(BP:positive regulation of neuron differentiation);GO:0032487(BP:regulation of Rap protein signal transduction);GO:0034097(BP:response to cytokine);GO:0042493(BP:response to drug);GO:0009725(BP:response to hormone);GO:0010033(BP:response to organic substance);GO:0009986(CC:cell surface);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1904813(CC:ficolin-1-rich granule lumen);GO:0030426(CC:growth cone);GO:0043025(CC:neuronal cell body);GO:0035580(CC:specific granule lumen);GO:1904724(CC:tertiary granule lumen);GO:0005178(MF:integrin binding);GO:0008191(MF:metalloendopeptidase inhibitor activity);GO:0030414(MF:peptidase inhibitor activity);GO:0002020(MF:protease binding);GO:0008270(MF:zinc ion binding)	-
Q6UXH8	1.701649	0.026879751	Collagen and calcium-binding EGF domain-containing protein 1	147372	CCBE1	GO:0030324(BP:lung development);GO:0001946(BP:lymphangiogenesis);GO:0045766(BP:positive regulation of angiogenesis);GO:0010595(BP:positive regulation of endothelial cell migration);GO:1901492(BP:positive regulation of lymphangiogenesis);GO:0010954(BP:positive regulation of protein processing);GO:0010575(BP:positive regulation of vascular endothelial growth factor production);GO:1900748(BP:positive regulation of vascular endothelial growth factor signaling pathway);GO:0003016(BP:respiratory system process);GO:0002040(BP:sprouting angiogenesis);GO:0048845(BP:venous blood vessel morphogenesis);GO:0005581(CC:collagen trimer);GO:0031012(CC:extracellular matrix);GO:0005615(CC:extracellular space);GO:0005509(MF:calcium ion binding);GO:0005518(MF:collagen binding);GO:0002020(MF:protease binding)	-
Q15800	1.695856	4.18E-05	Methylsterol monooxygenase 1	6307	MSMO1	GO:0006695(BP:cholesterol biosynthetic process);GO:0006631(BP:fatty acid metabolic process);GO:0008202(BP:steroid metabolic process);GO:0016126(BP:sterol biosynthetic process);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0000254(MF:C-4 methylsterol oxidase activity);GO:0005506(MF:iron ion binding)	hsa00100(Steroid biosynthesis)
Q8NHU3	1.691319	0.003062002	Phosphatidylcholine:ceramide cholinephosphotransferase 2	166929	SGMS2	GO:0046513(BP:ceramide biosynthetic process);GO:1905373(BP:ceramide phosphoethanolamine biosynthetic process);GO:0030148(BP:sphingolipid biosynthetic process);GO:0006686(BP:sphingomyelin biosynthetic process);GO:0005794(CC:Golgi apparatus);GO:0030176(CC:integral component of endoplasmic reticulum membrane);GO:0030173(CC:integral component of Golgi membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0047493(MF:ceramide cholinephosphotransferase activity);GO:0002950(MF:ceramide phosphoethanolamine synthase activity);GO:0016301(MF:kinase activity);GO:0033188(MF:sphingomyelin synthase activity)	hsa00600(Sphingolipid metabolism);hsa04071(Sphingolipid signaling pathway)
P02774	1.675125	0.044781847	Vitamin D-binding protein	2638	GC	GO:0042359(BP:vitamin D metabolic process);GO:0051180(BP:vitamin transport);GO:0072562(CC:blood microparticle);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0043202(CC:lysosomal lumen);GO:0003779(MF:actin binding);GO:1902118(MF:calcidiol binding);GO:0005499(MF:vitamin D binding);GO:0090482(MF:vitamin transmembrane transporter activity)	-
Q9NRX5	1.672726	2.75E-05	Serine incorporator 1	57515	SERINC1	"GO:0044091(BP:membrane biogenesis);GO:0006658(BP:phosphatidylserine metabolic process);GO:0008654(BP:phospholipid biosynthetic process);GO:1904219(BP:positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity);GO:1904222(BP:positive regulation of serine C-palmitoyltransferase activity);GO:0006665(BP:sphingolipid metabolic process);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0019899(MF:enzyme binding);GO:0030674(MF:protein binding, bridging)"	-
P17302	1.665826	1.72E-05	catenin	2697	GJA1	GO:0007512(BP:adult heart development);GO:0006915(BP:apoptotic process);GO:0015867(BP:ATP transport);GO:0086014(BP:atrial cardiac muscle cell action potential);GO:0003294(BP:atrial ventricular junction remodeling);GO:0048514(BP:blood vessel morphogenesis);GO:0060348(BP:bone development);GO:0046849(BP:bone remodeling);GO:0010643(BP:cell communication by chemical coupling);GO:0010644(BP:cell communication by electrical coupling);GO:0086064(BP:cell communication by electrical coupling involved in cardiac conduction);GO:0007267(BP:cell-cell signaling);GO:0071260(BP:cellular response to mechanical stimulus);GO:0071374(BP:cellular response to parathyroid hormone stimulus);GO:0071467(BP:cellular response to pH);GO:0002544(BP:chronic inflammatory response);GO:0046697(BP:decidualization);GO:0042733(BP:embryonic digit morphogenesis);GO:0003158(BP:endothelium development);GO:1905867(BP:epididymis development);GO:0002070(BP:epithelial cell maturation);GO:0016264(BP:gap junction assembly);GO:0007507(BP:heart development);GO:0001947(BP:heart looping);GO:0001701(BP:in utero embryonic development);GO:0034220(BP:ion transmembrane transport);GO:0002088(BP:lens development in camera-type eye);GO:0008584(BP:male gonad development);GO:0099111(BP:microtubule-based transport);GO:0060156(BP:milk ejection reflex);GO:0006936(BP:muscle contraction);GO:0060044(BP:negative regulation of cardiac muscle cell proliferation);GO:0030308(BP:negative regulation of cell growth);GO:2000279(BP:negative regulation of DNA biosynthetic process);GO:0001937(BP:negative regulation of endothelial cell proliferation);GO:0010629(BP:negative regulation of gene expression);GO:0061045(BP:negative regulation of wound healing);GO:0001764(BP:neuron migration);GO:0048812(BP:neuron projection morphogenesis);GO:0001649(BP:osteoblast differentiation);GO:2000987(BP:positive regulation of behavioral fear response);GO:0097755(BP:positive regulation of blood vessel diameter);GO:0010652(BP:positive regulation of cell communication by chemical coupling);GO:0007204(BP:positive regulation of cytosolic calcium ion concentration);GO:0010628(BP:positive regulation of gene expression);GO:0003104(BP:positive regulation of glomerular filtration);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0032024(BP:positive regulation of insulin secretion);GO:0045669(BP:positive regulation of osteoblast differentiation);GO:0045732(BP:positive regulation of protein catabolic process);GO:0045844(BP:positive regulation of striated muscle tissue development);GO:0045907(BP:positive regulation of vasoconstriction);GO:0051259(BP:protein complex oligomerization);GO:0042981(BP:regulation of apoptotic process);GO:0060371(BP:regulation of atrial cardiac muscle cell membrane depolarization);GO:2000810(BP:regulation of bicellular tight junction assembly);GO:0030500(BP:regulation of bone mineralization);GO:0046850(BP:regulation of bone remodeling);GO:0051924(BP:regulation of calcium ion transport);GO:0022898(BP:regulation of transmembrane transporter activity);GO:0060373(BP:regulation of ventricular cardiac muscle cell membrane depolarization);GO:0060307(BP:regulation of ventricular cardiac muscle cell membrane repolarization);GO:0032355(BP:response to estradiol);GO:0034405(BP:response to fluid shear stress);GO:0009749(BP:response to glucose);GO:0002931(BP:response to ischemia);GO:0032496(BP:response to lipopolysaccharide);GO:0043434(BP:response to peptide hormone);GO:0032526(BP:response to retinoic acid);GO:0007165(BP:signal transduction);GO:0043403(BP:skeletal muscle tissue regeneration);GO:0007283(BP:spermatogenesis);GO:0042098(BP:T cell proliferation);GO:0010232(BP:vascular transport);GO:0016324(CC:apical plasma membrane);GO:0030054(CC:cell junction);GO:0005922(CC:connexin complex);GO:0043292(CC:contractile fiber);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005769(CC:early endosome);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005916(CC:fascia adherens);GO:0005925(CC:focal adhesion);GO:0005921(CC:gap junction);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0030660(CC:Golgi-associated vesicle membrane);GO:0005887(CC:integral component of plasma membrane);GO:0014704(CC:intercalated disc);GO:0005882(CC:intermediate filament);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0016328(CC:lateral plasma membrane);GO:0005764(CC:lysosome);GO:0045121(CC:membrane raft);GO:0005741(CC:mitochondrial outer membrane);GO:0005739(CC:mitochondrion);GO:0005771(CC:multivesicular body);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0043014(MF:alpha-tubulin binding);GO:0048487(MF:beta-tubulin binding);GO:0071253(MF:connexin binding);GO:0097718(MF:disordered domain specific binding);GO:0005243(MF:gap junction channel activity);GO:0086075(MF:gap junction channel activity involved in cardiac conduction electrical coupling);GO:1903763(MF:gap junction channel activity involved in cell communication by electrical coupling);GO:0055077(MF:gap junction hemi-channel activity);GO:0015075(MF:ion transmembrane transporter activity);GO:0030165(MF:PDZ domain binding);GO:1990782(MF:protein tyrosine kinase binding);GO:0097110(MF:scaffold protein binding);GO:0017124(MF:SH3 domain binding);GO:0005102(MF:signaling receptor binding);GO:0015631(MF:tubulin binding)	hsa04540(Gap junction);hsa05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC))
Q15025	1.654567	2.03E-05	TNFAIP3-interacting protein 1	10318	TNIP1	GO:0006952(BP:defense response);GO:0009101(BP:glycoprotein biosynthetic process);GO:0006954(BP:inflammatory response);GO:0007159(BP:leukocyte cell-cell adhesion);GO:0085032(BP:modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade);GO:0002755(BP:MyD88-dependent toll-like receptor signaling pathway);GO:0070373(BP:negative regulation of ERK1 and ERK2 cascade);GO:0043124(BP:negative regulation of I-kappaB kinase/NF-kappaB signaling);GO:0045071(BP:negative regulation of viral genome replication);GO:0050729(BP:positive regulation of inflammatory response);GO:1903003(BP:positive regulation of protein deubiquitination);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0016579(BP:protein deubiquitination);GO:0006412(BP:translation);GO:0005829(CC:cytosol);GO:0005654(CC:nucleoplasm);GO:0042802(MF:identical protein binding);GO:0051019(MF:mitogen-activated protein kinase binding)	-
P41273	1.648598	0.002121194	Tumor necrosis factor ligand superfamily member 9	8744	TNFSF9	GO:0006915(BP:apoptotic process);GO:0008283(BP:cell proliferation);GO:0007267(BP:cell-cell signaling);GO:0006955(BP:immune response);GO:0042104(BP:positive regulation of activated T cell proliferation);GO:0045585(BP:positive regulation of cytotoxic T cell differentiation);GO:0007165(BP:signal transduction);GO:0033209(BP:tumor necrosis factor-mediated signaling pathway);GO:0005615(CC:extracellular space);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0005125(MF:cytokine activity);GO:0005102(MF:signaling receptor binding);GO:0005164(MF:tumor necrosis factor receptor binding);GO:0032813(MF:tumor necrosis factor receptor superfamily binding)	hsa04060(Cytokine-cytokine receptor interaction)
P36941	1.647548	5.48E-05	Tumor necrosis factor receptor superfamily member 3	4055	LTBR	GO:0006915(BP:apoptotic process);GO:0071260(BP:cellular response to mechanical stimulus);GO:0006955(BP:immune response);GO:0043011(BP:myeloid dendritic cell differentiation);GO:2001238(BP:positive regulation of extrinsic apoptotic signaling pathway);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0046330(BP:positive regulation of JNK cascade);GO:0007165(BP:signal transduction);GO:0033209(BP:tumor necrosis factor-mediated signaling pathway);GO:0016032(BP:viral process);GO:0005794(CC:Golgi apparatus);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0042802(MF:identical protein binding);GO:0031625(MF:ubiquitin protein ligase binding)	hsa04060(Cytokine-cytokine receptor interaction);hsa04672(Intestinal immune network for IgA production);hsa04064(NF-kappa B signaling pathway);hsa05203(Viral carcinogenesis);hsa05166(Human T-cell leukemia virus 1 infection);hsa04066(HIF-1 signaling pathway)
P13164	1.639678	0.021483861	Interferon-induced transmembrane protein 1	8519	IFITM1	GO:0007166(BP:cell surface receptor signaling pathway);GO:0051607(BP:defense response to virus);GO:0030336(BP:negative regulation of cell migration);GO:0008285(BP:negative regulation of cell proliferation);GO:0046597(BP:negative regulation of viral entry into host cell);GO:0045071(BP:negative regulation of viral genome replication);GO:0001503(BP:ossification);GO:0045669(BP:positive regulation of osteoblast differentiation);GO:0050776(BP:regulation of immune response);GO:0035455(BP:response to interferon-alpha);GO:0035456(BP:response to interferon-beta);GO:0034341(BP:response to interferon-gamma);GO:0009615(BP:response to virus);GO:0060337(BP:type I interferon signaling pathway);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0032991(CC:protein-containing complex)	hsa04662(B cell receptor signaling pathway)
Q14534	1.639184	0.042344486	Squalene monooxygenase	6713	SQLE	GO:0006725(BP:cellular aromatic compound metabolic process);GO:0006695(BP:cholesterol biosynthetic process);GO:0008203(BP:cholesterol metabolic process);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0010033(BP:response to organic substance);GO:0016126(BP:sterol biosynthetic process);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0050660(MF:flavin adenine dinucleotide binding);GO:0004506(MF:squalene monooxygenase activity)	hsa00100(Steroid biosynthesis)
P02461	1.638962	1.43E-05	Collagen alpha-1(III) chain	1281	COL3A1	GO:0060414(BP:aorta smooth muscle tissue morphogenesis);GO:0007160(BP:cell-matrix adhesion);GO:0071230(BP:cellular response to amino acid stimulus);GO:0021987(BP:cerebral cortex development);GO:0030199(BP:collagen fibril organization);GO:0048565(BP:digestive tract development);GO:0030198(BP:extracellular matrix organization);GO:0007507(BP:heart development);GO:0007229(BP:integrin-mediated signaling pathway);GO:0050777(BP:negative regulation of immune response);GO:2001223(BP:negative regulation of neuron migration);GO:0018149(BP:peptide cross-linking);GO:0030168(BP:platelet activation);GO:0035025(BP:positive regulation of Rho protein signal transduction);GO:0050776(BP:regulation of immune response);GO:0034097(BP:response to cytokine);GO:0009612(BP:response to mechanical stimulus);GO:0009314(BP:response to radiation);GO:0001501(BP:skeletal system development);GO:0043588(BP:skin development);GO:0097435(BP:supramolecular fiber organization);GO:0007179(BP:transforming growth factor beta receptor signaling pathway);GO:0042060(BP:wound healing);GO:0005586(CC:collagen type III trimer);GO:0005788(CC:endoplasmic reticulum lumen);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005201(MF:extracellular matrix structural constituent);GO:0030020(MF:extracellular matrix structural constituent conferring tensile strength);GO:0005178(MF:integrin binding);GO:0046872(MF:metal ion binding);GO:0048407(MF:platelet-derived growth factor binding);GO:0002020(MF:protease binding);GO:0046332(MF:SMAD binding)	hsa04926(Relaxin signaling pathway);hsa04974(Protein digestion and absorption);hsa04611(Platelet activation);hsa04933(AGE-RAGE signaling pathway in diabetic complications);hsa05146(Amoebiasis)
Q86VP1	1.622252	6.87E-05	Tax1-binding protein 1	8887	TAX1BP1	GO:0006915(BP:apoptotic process);GO:0043066(BP:negative regulation of apoptotic process);GO:0032088(BP:negative regulation of NF-kappaB transcription factor activity);GO:0032480(BP:negative regulation of type I interferon production);GO:0010803(BP:regulation of tumor necrosis factor-mediated signaling pathway);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0019900(MF:kinase binding);GO:0046872(MF:metal ion binding)	hsa04137(Mitophagy - animal)
O00560	1.619014	0.000180025	Syntenin-1	6386	SDCBP	"GO:0030036(BP:actin cytoskeleton organization);GO:0007268(BP:chemical synaptic transmission);GO:0048013(BP:ephrin receptor signaling pathway);GO:0035556(BP:intracellular signal transduction);GO:0032435(BP:negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0002091(BP:negative regulation of receptor internalization);GO:0043312(BP:neutrophil degranulation);GO:0030307(BP:positive regulation of cell growth);GO:0030335(BP:positive regulation of cell migration);GO:0008284(BP:positive regulation of cell proliferation);GO:0010718(BP:positive regulation of epithelial to mesenchymal transition);GO:1903543(BP:positive regulation of exosomal secretion);GO:1903553(BP:positive regulation of extracellular exosome assembly);GO:0046330(BP:positive regulation of JNK cascade);GO:0010862(BP:positive regulation of pathway-restricted SMAD protein phosphorylation);GO:0042327(BP:positive regulation of phosphorylation);GO:0030511(BP:positive regulation of transforming growth factor beta receptor signaling pathway);GO:0006612(BP:protein targeting to membrane);GO:0007346(BP:regulation of mitotic cell cycle);GO:0006930(BP:substrate-dependent cell migration, cell extension);GO:0005912(CC:adherens junction);GO:0035578(CC:azurophil granule lumen);GO:0072562(CC:blood microparticle);GO:0005737(CC:cytoplasm);GO:0005856(CC:cytoskeleton);GO:0005829(CC:cytosol);GO:0005789(CC:endoplasmic reticulum membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1903561(CC:extracellular vesicle);GO:0005925(CC:focal adhesion);GO:0005895(CC:interleukin-5 receptor complex);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0042470(CC:melanosome);GO:0016020(CC:membrane);GO:0045121(CC:membrane raft);GO:0031965(CC:nuclear membrane);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0008093(MF:cytoskeletal adaptor activity);GO:0005109(MF:frizzled binding);GO:0042802(MF:identical protein binding);GO:0005137(MF:interleukin-5 receptor binding);GO:0005546(MF:phosphatidylinositol-4,5-bisphosphate binding);GO:0046982(MF:protein heterodimerization activity);GO:0047485(MF:protein N-terminus binding);GO:0045545(MF:syndecan binding)"	-
Q13137	1.61596	1.86E-05	Calcium-binding and coiled-coil domain-containing protein 2	10241	CALCOCO2	GO:1901098(BP:positive regulation of autophagosome maturation);GO:0034341(BP:response to interferon-gamma);GO:0016032(BP:viral process);GO:0098792(BP:xenophagy);GO:0005776(CC:autophagosome);GO:0000421(CC:autophagosome membrane);GO:0005737(CC:cytoplasm);GO:0031410(CC:cytoplasmic vesicle);GO:0005856(CC:cytoskeleton);GO:0005829(CC:cytosol);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0016020(CC:membrane);GO:0005634(CC:nucleus);GO:0048471(CC:perinuclear region of cytoplasm);GO:0042803(MF:protein homodimerization activity)	hsa04137(Mitophagy - animal)
Q15043	1.612613	0.000847172	Zinc transporter ZIP14	23516	SLC39A14	GO:0006882(BP:cellular zinc ion homeostasis);GO:0071578(BP:zinc ion import across plasma membrane);GO:0071577(BP:zinc ion transmembrane transport);GO:0005737(CC:cytoplasm);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0030027(CC:lamellipodium);GO:0005886(CC:plasma membrane);GO:0015093(MF:ferrous iron transmembrane transporter activity);GO:0005384(MF:manganese ion transmembrane transporter activity);GO:0005385(MF:zinc ion transmembrane transporter activity)	hsa04216(Ferroptosis)
P11169	1.60824	9.02E-05	"Solute carrier family 2, facilitated glucose transporter member 3"	6515	SLC2A3	GO:0005975(BP:carbohydrate metabolic process);GO:1904659(BP:glucose transmembrane transport);GO:0019852(BP:L-ascorbic acid metabolic process);GO:0043312(BP:neutrophil degranulation);GO:0042995(CC:cell projection);GO:0070062(CC:extracellular exosome);GO:0101003(CC:ficolin-1-rich granule membrane);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0043204(CC:perikaryon);GO:0005886(CC:plasma membrane);GO:0030667(CC:secretory granule membrane);GO:0035579(CC:specific granule membrane);GO:0070821(CC:tertiary granule membrane);GO:0005536(MF:glucose binding);GO:0005355(MF:glucose transmembrane transporter activity)	-
P26012	1.606781	0.00355202	Integrin beta-8	3696	ITGB8	GO:0051216(BP:cartilage development);GO:0007155(BP:cell adhesion);GO:0033627(BP:cell adhesion mediated by integrin);GO:0016477(BP:cell migration);GO:0030198(BP:extracellular matrix organization);GO:0001573(BP:ganglioside metabolic process);GO:0007229(BP:integrin-mediated signaling pathway);GO:0010629(BP:negative regulation of gene expression);GO:0060674(BP:placenta blood vessel development);GO:0045766(BP:positive regulation of angiogenesis);GO:0010628(BP:positive regulation of gene expression);GO:1901388(BP:regulation of transforming growth factor beta activation);GO:0001570(BP:vasculogenesis);GO:0009986(CC:cell surface);GO:0070062(CC:extracellular exosome);GO:0005925(CC:focal adhesion);GO:0034686(CC:integrin alphav-beta8 complex);GO:0008305(CC:integrin complex);GO:0005886(CC:plasma membrane);GO:1990430(MF:extracellular matrix protein binding);GO:0005178(MF:integrin binding);GO:0038023(MF:signaling receptor activity)	hsa05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));hsa05414(Dilated cardiomyopathy (DCM));hsa04514(Cell adhesion molecules (CAMs));hsa04512(ECM-receptor interaction);hsa04810(Regulation of actin cytoskeleton);hsa04151(PI3K-Akt signaling pathway);hsa05165(Human papillomavirus infection);hsa04510(Focal adhesion);hsa05410(Hypertrophic cardiomyopathy (HCM))
Q9UNA0	1.603215	0.004052049	A disintegrin and metalloproteinase with thrombospondin motifs 5	11096	ADAMTS5	GO:0042742(BP:defense response to bacterium);GO:0022617(BP:extracellular matrix disassembly);GO:0006508(BP:proteolysis);GO:0044691(BP:tooth eruption);GO:0005788(CC:endoplasmic reticulum lumen);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0050840(MF:extracellular matrix binding);GO:0008201(MF:heparin binding);GO:0005178(MF:integrin binding);GO:0004222(MF:metalloendopeptidase activity);GO:0008237(MF:metallopeptidase activity);GO:0008270(MF:zinc ion binding)	-
P02647	1.593528	0.005871456	Apolipoprotein A-I	335	APOA1	GO:0030325(BP:adrenal gland development);GO:0031100(BP:animal organ regeneration);GO:0043534(BP:blood vessel endothelial cell migration);GO:0044267(BP:cellular protein metabolic process);GO:0006695(BP:cholesterol biosynthetic process);GO:0033344(BP:cholesterol efflux);GO:0042632(BP:cholesterol homeostasis);GO:0070508(BP:cholesterol import);GO:0008203(BP:cholesterol metabolic process);GO:0030301(BP:cholesterol transport);GO:0034378(BP:chylomicron assembly);GO:0034371(BP:chylomicron remodeling);GO:0001935(BP:endothelial cell proliferation);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0008211(BP:glucocorticoid metabolic process);GO:0034380(BP:high-density lipoprotein particle assembly);GO:0034384(BP:high-density lipoprotein particle clearance);GO:0034375(BP:high-density lipoprotein particle remodeling);GO:0007229(BP:integrin-mediated signaling pathway);GO:0019915(BP:lipid storage);GO:0042158(BP:lipoprotein biosynthetic process);GO:0042157(BP:lipoprotein metabolic process);GO:0050919(BP:negative chemotaxis);GO:0060354(BP:negative regulation of cell adhesion molecule production);GO:0002740(BP:negative regulation of cytokine secretion involved in immune response);GO:0034115(BP:negative regulation of heterotypic cell-cell adhesion);GO:0050728(BP:negative regulation of inflammatory response);GO:0050713(BP:negative regulation of interleukin-1 beta secretion);GO:0060192(BP:negative regulation of lipase activity);GO:0060761(BP:negative regulation of response to cytokine stimulus);GO:0010804(BP:negative regulation of tumor necrosis factor-mediated signaling pathway);GO:0010903(BP:negative regulation of very-low-density lipoprotein particle remodeling);GO:0018206(BP:peptidyl-methionine modification);GO:0014012(BP:peripheral nervous system axon regeneration);GO:0006656(BP:phosphatidylcholine biosynthetic process);GO:0033700(BP:phospholipid efflux);GO:0055091(BP:phospholipid homeostasis);GO:0002576(BP:platelet degranulation);GO:0010875(BP:positive regulation of cholesterol efflux);GO:0010873(BP:positive regulation of cholesterol esterification);GO:0051345(BP:positive regulation of hydrolase activity);GO:0046889(BP:positive regulation of lipid biosynthetic process);GO:0050766(BP:positive regulation of phagocytosis);GO:1902995(BP:positive regulation of phospholipid efflux);GO:0035025(BP:positive regulation of Rho protein signal transduction);GO:0051496(BP:positive regulation of stress fiber assembly);GO:1900026(BP:positive regulation of substrate adhesion-dependent cell spreading);GO:0043687(BP:post-translational protein modification);GO:0018158(BP:protein oxidation);GO:0050821(BP:protein stabilization);GO:0006898(BP:receptor-mediated endocytosis);GO:0032489(BP:regulation of Cdc42 protein signal transduction);GO:0032374(BP:regulation of cholesterol transport);GO:0030300(BP:regulation of intestinal cholesterol absorption);GO:0019216(BP:regulation of lipid metabolic process);GO:0001932(BP:regulation of protein phosphorylation);GO:0042493(BP:response to drug);GO:0043627(BP:response to estrogen);GO:0007584(BP:response to nutrient);GO:0001523(BP:retinoid metabolic process);GO:0043691(BP:reverse cholesterol transport);GO:0055085(BP:transmembrane transport);GO:0019433(BP:triglyceride catabolic process);GO:0070328(BP:triglyceride homeostasis);GO:0034372(BP:very-low-density lipoprotein particle remodeling);GO:0051180(BP:vitamin transport);GO:0072562(CC:blood microparticle);GO:0009986(CC:cell surface);GO:0042627(CC:chylomicron);GO:0031410(CC:cytoplasmic vesicle);GO:0005829(CC:cytosol);GO:0034365(CC:discoidal high-density lipoprotein particle);GO:0005769(CC:early endosome);GO:0030139(CC:endocytic vesicle);GO:0071682(CC:endocytic vesicle lumen);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1903561(CC:extracellular vesicle);GO:0034364(CC:high-density lipoprotein particle);GO:0034363(CC:intermediate-density lipoprotein particle);GO:0034362(CC:low-density lipoprotein particle);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0034774(CC:secretory granule lumen);GO:0034366(CC:spherical high-density lipoprotein particle);GO:0034361(CC:very-low-density lipoprotein particle);GO:0001540(MF:amyloid-beta binding);GO:0034191(MF:apolipoprotein A-I receptor binding);GO:0034190(MF:apolipoprotein receptor binding);GO:0045499(MF:chemorepellent activity);GO:0015485(MF:cholesterol binding);GO:0017127(MF:cholesterol transporter activity);GO:0019899(MF:enzyme binding);GO:0031072(MF:heat shock protein binding);GO:0008035(MF:high-density lipoprotein particle binding);GO:0070653(MF:high-density lipoprotein particle receptor binding);GO:0042802(MF:identical protein binding);GO:0055102(MF:lipase inhibitor activity);GO:0060228(MF:phosphatidylcholine-sterol O-acyltransferase activator activity);GO:0005543(MF:phospholipid binding);GO:0005548(MF:phospholipid transporter activity);GO:0005102(MF:signaling receptor binding)	hsa04977(Vitamin digestion and absorption);hsa04975(Fat digestion and absorption);hsa04979(Cholesterol metabolism);hsa05143(African trypanosomiasis);hsa03320(PPAR signaling pathway)
P60520	1.5913	0.003894724	Gamma-aminobutyric acid receptor-associated protein-like 2	11345	GABARAPL2	GO:0000045(BP:autophagosome assembly);GO:0097352(BP:autophagosome maturation);GO:0006914(BP:autophagy);GO:0000422(BP:autophagy of mitochondrion);GO:0006995(BP:cellular response to nitrogen starvation);GO:0006891(BP:intra-Golgi vesicle-mediated transport);GO:0016236(BP:macroautophagy);GO:1901799(BP:negative regulation of proteasomal protein catabolic process);GO:0032781(BP:positive regulation of ATPase activity);GO:0015031(BP:protein transport);GO:0005776(CC:autophagosome);GO:0000421(CC:autophagosome membrane);GO:0005737(CC:cytoplasm);GO:0031410(CC:cytoplasmic vesicle);GO:0005829(CC:cytosol);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0005622(CC:intracellular);GO:0051117(MF:ATPase binding);GO:0048487(MF:beta-tubulin binding);GO:0050811(MF:GABA receptor binding);GO:0008017(MF:microtubule binding);GO:0000149(MF:SNARE binding);GO:0031625(MF:ubiquitin protein ligase binding)	hsa04727(GABAergic synapse);hsa04068(FoxO signaling pathway);hsa05167(Kaposi sarcoma-associated herpesvirus infection);hsa04371(Apelin signaling pathway);hsa04140(Autophagy - animal);hsa04621(NOD-like receptor signaling pathway);hsa04136(Autophagy - other);hsa04137(Mitophagy - animal)
Q9NQ84	1.578104	0.001085595	G-protein coupled receptor family C group 5 member C	55890	GPRC5C	GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0030659(CC:cytoplasmic vesicle membrane);GO:0070062(CC:extracellular exosome);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0043235(CC:receptor complex);GO:0031982(CC:vesicle);GO:0004930(MF:G-protein coupled receptor activity);GO:0030295(MF:protein kinase activator activity)	-
P50281	1.576351	4.82E-06	Matrix metalloproteinase-14	4323	MMP14	GO:0001525(BP:angiogenesis);GO:0043615(BP:astrocyte cell migration);GO:0048754(BP:branching morphogenesis of an epithelial tube);GO:0048870(BP:cell motility);GO:0035988(BP:chondrocyte proliferation);GO:0030574(BP:collagen catabolic process);GO:0097094(BP:craniofacial suture morphogenesis);GO:0048701(BP:embryonic cranial skeleton morphogenesis);GO:0001958(BP:endochondral ossification);GO:0035987(BP:endodermal cell differentiation);GO:0001935(BP:endothelial cell proliferation);GO:0022617(BP:extracellular matrix disassembly);GO:0030198(BP:extracellular matrix organization);GO:0060322(BP:head development);GO:0030324(BP:lung development);GO:0008584(BP:male gonad development);GO:0051895(BP:negative regulation of focal adhesion assembly);GO:0045746(BP:negative regulation of Notch signaling pathway);GO:0001541(BP:ovarian follicle development);GO:0045579(BP:positive regulation of B cell differentiation);GO:0030307(BP:positive regulation of cell growth);GO:0030335(BP:positive regulation of cell migration);GO:1905523(BP:positive regulation of macrophage migration);GO:0010831(BP:positive regulation of myotube differentiation);GO:0010954(BP:positive regulation of protein processing);GO:0016485(BP:protein processing);GO:0006508(BP:proteolysis);GO:1903076(BP:regulation of protein localization to plasma membrane);GO:0043627(BP:response to estrogen);GO:0009725(BP:response to hormone);GO:0001666(BP:response to hypoxia);GO:0009612(BP:response to mechanical stimulus);GO:1990834(BP:response to odorant);GO:0014070(BP:response to organic cyclic compound);GO:0006979(BP:response to oxidative stress);GO:0001501(BP:skeletal system development);GO:0048771(BP:tissue remodeling);GO:0031638(BP:zymogen activation);GO:0031410(CC:cytoplasmic vesicle);GO:0005829(CC:cytosol);GO:0031012(CC:extracellular matrix);GO:0005615(CC:extracellular space);GO:0005925(CC:focal adhesion);GO:0005796(CC:Golgi lumen);GO:0005887(CC:integral component of plasma membrane);GO:0045111(CC:intermediate filament cytoskeleton);GO:0044354(CC:macropinosome);GO:0042470(CC:melanosome);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0004175(MF:endopeptidase activity);GO:0005178(MF:integrin binding);GO:0070006(MF:metalloaminopeptidase activity);GO:0004222(MF:metalloendopeptidase activity);GO:0008270(MF:zinc ion binding)	"hsa04928(Parathyroid hormone synthesis, secretion and action);hsa04912(GnRH signaling pathway);hsa04668(TNF signaling pathway)"
P17676	1.574226	0.005932643	CCAAT/enhancer-binding protein beta	1051	CEBPB	"GO:0006953(BP:acute-phase response);GO:0050873(BP:brown fat cell differentiation);GO:0071230(BP:cellular response to amino acid stimulus);GO:0071347(BP:cellular response to interleukin-1);GO:0071222(BP:cellular response to lipopolysaccharide);GO:0071407(BP:cellular response to organic cyclic compound);GO:0042742(BP:defense response to bacterium);GO:0001892(BP:embryonic placenta development);GO:0002432(BP:granuloma formation);GO:0072574(BP:hepatocyte proliferation);GO:0006955(BP:immune response);GO:0006954(BP:inflammatory response);GO:0070059(BP:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress);GO:0097421(BP:liver regeneration);GO:0060644(BP:mammary gland epithelial cell differentiation);GO:0033598(BP:mammary gland epithelial cell proliferation);GO:0007613(BP:memory);GO:0043524(BP:negative regulation of neuron apoptotic process);GO:0042130(BP:negative regulation of T cell proliferation);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0030182(BP:neuron differentiation);GO:0001541(BP:ovarian follicle development);GO:0070169(BP:positive regulation of biomineral tissue development);GO:0045600(BP:positive regulation of fat cell differentiation);GO:0050729(BP:positive regulation of inflammatory response);GO:0032753(BP:positive regulation of interleukin-4 production);GO:0045669(BP:positive regulation of osteoblast differentiation);GO:2000120(BP:positive regulation of sodium-dependent phosphate transport);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:1990440(BP:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress);GO:0045893(BP:positive regulation of transcription, DNA-templated);GO:2001198(BP:regulation of dendritic cell differentiation);GO:0045408(BP:regulation of interleukin-6 biosynthetic process);GO:1901329(BP:regulation of odontoblast differentiation);GO:0045670(BP:regulation of osteoclast differentiation);GO:0060850(BP:regulation of transcription involved in cell fate commitment);GO:0006355(BP:regulation of transcription, DNA-templated);GO:0034976(BP:response to endoplasmic reticulum stress);GO:0035711(BP:T-helper 1 cell activation);GO:0006366(BP:transcription by RNA polymerase II);GO:0036488(CC:CHOP-C/EBP complex);GO:0000779(CC:condensed chromosome, centromeric region);GO:0005737(CC:cytoplasm);GO:0000790(CC:nuclear chromatin);GO:0016363(CC:nuclear matrix);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0003682(MF:chromatin binding);GO:0003677(MF:DNA binding);GO:0001228(MF:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding);GO:0003700(MF:DNA binding transcription factor activity);GO:0000981(MF:RNA polymerase II transcription factor activity, sequence-specific DNA binding);GO:0001227(MF:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding);GO:0035259(MF:glucocorticoid receptor binding);GO:0035035(MF:histone acetyltransferase binding);GO:0042826(MF:histone deacetylase binding);GO:0019900(MF:kinase binding);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity);GO:0000979(MF:RNA polymerase II core promoter sequence-specific DNA binding);GO:0000978(MF:RNA polymerase II proximal promoter sequence-specific DNA binding);GO:0000977(MF:RNA polymerase II regulatory region sequence-specific DNA binding);GO:0044389(MF:ubiquitin-like protein ligase binding)"	hsa05202(Transcriptional misregulation in cancer);hsa05152(Tuberculosis);hsa04657(IL-17 signaling pathway);hsa04668(TNF signaling pathway)
Q9NRA2	1.566486	0.005225271	Sialin	26503	SLC17A5	GO:0006865(BP:amino acid transport);GO:0006820(BP:anion transport);GO:0006811(BP:ion transport);GO:0009617(BP:response to bacterium);GO:0015739(BP:sialic acid transport);GO:0030054(CC:cell junction);GO:0005829(CC:cytosol);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005765(CC:lysosomal membrane);GO:0005764(CC:lysosome);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0030672(CC:synaptic vesicle membrane);GO:0005351(MF:carbohydrate:proton symporter activity);GO:0015136(MF:sialic acid transmembrane transporter activity);GO:0015538(MF:sialic acid:proton symporter activity)	hsa04142(Lysosome)
Q9ULY5	1.564909	0.001465529	C-type lectin domain family 4 member E	26253	CLEC4E	GO:0042742(BP:defense response to bacterium);GO:0038094(BP:Fc-gamma receptor signaling pathway);GO:0045087(BP:innate immune response);GO:0002221(BP:pattern recognition receptor signaling pathway);GO:0050715(BP:positive regulation of cytokine secretion);GO:0002223(BP:stimulatory C-type lectin receptor signaling pathway);GO:0002292(BP:T cell differentiation involved in immune response);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0005509(MF:calcium ion binding);GO:0030246(MF:carbohydrate binding);GO:0038187(MF:pattern recognition receptor activity)	hsa05152(Tuberculosis);hsa04625(C-type lectin receptor signaling pathway)
Q16739	1.561434	0.003375139	Ceramide glucosyltransferase	7357	UGCG	GO:0030154(BP:cell differentiation);GO:1903575(BP:cornified envelope assembly);GO:0008544(BP:epidermis development);GO:0061436(BP:establishment of skin barrier);GO:0006679(BP:glucosylceramide biosynthetic process);GO:0006687(BP:glycosphingolipid metabolic process);GO:0098856(BP:intestinal lipid absorption);GO:0030216(BP:keratinocyte differentiation);GO:0033210(BP:leptin-mediated signaling pathway);GO:0048666(BP:neuron development);GO:0006497(BP:protein lipidation);GO:0009966(BP:regulation of signal transduction);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane);GO:0008120(MF:ceramide glucosyltransferase activity);GO:0102769(MF:dihydroceramide glucosyltransferase activity)	hsa00600(Sphingolipid metabolism)
Q9ULG6	1.541568	0.000101416	Cell cycle progression protein 1	9236	CCPG1	GO:0007049(BP:cell cycle);GO:0045787(BP:positive regulation of cell cycle);GO:0008284(BP:positive regulation of cell proliferation);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:2001106(BP:regulation of Rho guanyl-nucleotide exchange factor activity);GO:0016021(CC:integral component of membrane)	-
P08123	1.539843	0.000333221	Collagen alpha-2(I) chain	1278	COL1A2	"GO:0007596(BP:blood coagulation);GO:0001568(BP:blood vessel development);GO:0030282(BP:bone mineralization);GO:0071230(BP:cellular response to amino acid stimulus);GO:0030199(BP:collagen fibril organization);GO:0032963(BP:collagen metabolic process);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0085029(BP:extracellular matrix assembly);GO:0030198(BP:extracellular matrix organization);GO:0050900(BP:leukocyte migration);GO:0042476(BP:odontogenesis);GO:0030168(BP:platelet activation);GO:0070208(BP:protein heterotrimerization);GO:0008217(BP:regulation of blood pressure);GO:0050776(BP:regulation of immune response);GO:0007266(BP:Rho protein signal transduction);GO:0001501(BP:skeletal system development);GO:0043589(BP:skin morphogenesis);GO:0007179(BP:transforming growth factor beta receptor signaling pathway);GO:0005584(CC:collagen type I trimer);GO:0005783(CC:endoplasmic reticulum);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005201(MF:extracellular matrix structural constituent);GO:0030020(MF:extracellular matrix structural constituent conferring tensile strength);GO:0042802(MF:identical protein binding);GO:0046872(MF:metal ion binding);GO:0048407(MF:platelet-derived growth factor binding);GO:0002020(MF:protease binding);GO:0030674(MF:protein binding, bridging);GO:0046332(MF:SMAD binding)"	hsa05165(Human papillomavirus infection);hsa04926(Relaxin signaling pathway);hsa04510(Focal adhesion);hsa04974(Protein digestion and absorption);hsa04512(ECM-receptor interaction);hsa05146(Amoebiasis);hsa04611(Platelet activation);hsa04151(PI3K-Akt signaling pathway);hsa04933(AGE-RAGE signaling pathway in diabetic complications)
P27701	1.538033	0.010404931	CD82 antigen	3732	CD82	GO:0007166(BP:cell surface receptor signaling pathway);GO:0070062(CC:extracellular exosome);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane)	hsa04115(p53 signaling pathway)
O60462	1.530808	0.000615666	Neuropilin-2	8828	NRP2	GO:0001525(BP:angiogenesis);GO:0048846(BP:axon extension involved in axon guidance);GO:0007411(BP:axon guidance);GO:0007155(BP:cell adhesion);GO:1990830(BP:cellular response to leukemia inhibitory factor);GO:1904835(BP:dorsal root ganglion morphogenesis);GO:0021612(BP:facial nerve structural organization);GO:1903375(BP:facioacoustic ganglion development);GO:0021828(BP:gonadotrophin-releasing hormone neuronal migration to the hypothalamus);GO:0050919(BP:negative chemotaxis);GO:0021675(BP:nerve development);GO:1901166(BP:neural crest cell migration involved in autonomic nervous system development);GO:0003148(BP:outflow tract septum morphogenesis);GO:0010595(BP:positive regulation of endothelial cell migration);GO:0001938(BP:positive regulation of endothelial cell proliferation);GO:0099175(BP:regulation of postsynapse organization);GO:1902285(BP:semaphorin-plexin signaling pathway involved in neuron projection guidance);GO:0097374(BP:sensory neuron axon guidance);GO:0061549(BP:sympathetic ganglion development);GO:0097490(BP:sympathetic neuron projection extension);GO:0097491(BP:sympathetic neuron projection guidance);GO:0061551(BP:trigeminal ganglion development);GO:0048010(BP:vascular endothelial growth factor receptor signaling pathway);GO:0036486(BP:ventral trunk neural crest cell migration);GO:0021649(BP:vestibulocochlear nerve structural organization);GO:0016032(BP:viral process);GO:0030424(CC:axon);GO:0005576(CC:extracellular region);GO:0098978(CC:glutamatergic synapse);GO:0016021(CC:integral component of membrane);GO:0099055(CC:integral component of postsynaptic membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0002116(CC:semaphorin receptor complex);GO:0019955(MF:cytokine binding);GO:0019838(MF:growth factor binding);GO:0008201(MF:heparin binding);GO:0042802(MF:identical protein binding);GO:0046872(MF:metal ion binding);GO:0017154(MF:semaphorin receptor activity);GO:0038023(MF:signaling receptor activity);GO:0005021(MF:vascular endothelial growth factor-activated receptor activity)	-
Q8TF66	1.525781	0.042080709	Leucine-rich repeat-containing protein 15	131578	LRRC15	GO:1903077(BP:negative regulation of protein localization to plasma membrane);GO:0030335(BP:positive regulation of cell migration);GO:0046813(BP:receptor-mediated virion attachment to host cell);GO:0070062(CC:extracellular exosome);GO:0031012(CC:extracellular matrix);GO:0005615(CC:extracellular space);GO:0016021(CC:integral component of membrane);GO:0005518(MF:collagen binding);GO:0001968(MF:fibronectin binding);GO:0043236(MF:laminin binding)	-
Q7Z4F1	1.525446	0.000438552	Low-density lipoprotein receptor-related protein 10	26020	LRP10	GO:0048839(BP:inner ear development);GO:0006629(BP:lipid metabolic process);GO:0006869(BP:lipid transport);GO:0005905(CC:clathrin-coated pit);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005041(MF:low-density lipoprotein particle receptor activity)	-
O43291	1.522756	0.007682174	Kunitz-type protease inhibitor 2	10653	SPINT2	GO:0071711(BP:basement membrane organization);GO:0071773(BP:cellular response to BMP stimulus);GO:0060672(BP:epithelial cell morphogenesis involved in placental branching);GO:0007163(BP:establishment or maintenance of cell polarity);GO:2000146(BP:negative regulation of cell motility);GO:0022408(BP:negative regulation of cell-cell adhesion);GO:2000178(BP:negative regulation of neural precursor cell proliferation);GO:0001843(BP:neural tube closure);GO:0005737(CC:cytoplasm);GO:0005576(CC:extracellular region);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0004866(MF:endopeptidase inhibitor activity);GO:0004867(MF:serine-type endopeptidase inhibitor activity)	-
Q5W0Z9	1.520806	0.000556961	Palmitoyltransferase ZDHHC20	253832	ZDHHC20	GO:0018230(BP:peptidyl-L-cysteine S-palmitoylation);GO:0018345(BP:protein palmitoylation);GO:0006612(BP:protein targeting to membrane);GO:0005783(CC:endoplasmic reticulum);GO:0005794(CC:Golgi apparatus);GO:0030173(CC:integral component of Golgi membrane);GO:0016020(CC:membrane);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0016409(MF:palmitoyltransferase activity);GO:0019706(MF:protein-cysteine S-palmitoyltransferase activity);GO:0008270(MF:zinc ion binding)	-
Q99985	1.520653	0.00225337	Semaphorin-3C	10512	SEMA3C	GO:0007411(BP:axon guidance);GO:0001974(BP:blood vessel remodeling);GO:0140074(BP:cardiac endothelial to mesenchymal transition);GO:0003215(BP:cardiac right ventricle morphogenesis);GO:0060666(BP:dichotomous subdivision of terminal units involved in salivary gland branching);GO:0006955(BP:immune response);GO:0060174(BP:limb bud formation);GO:0050919(BP:negative chemotaxis);GO:0048843(BP:negative regulation of axon extension involved in axon guidance);GO:0001755(BP:neural crest cell migration);GO:0021915(BP:neural tube development);GO:0003148(BP:outflow tract septum morphogenesis);GO:1905312(BP:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis);GO:0030335(BP:positive regulation of cell migration);GO:0009791(BP:post-embryonic development);GO:0003350(BP:pulmonary myocardium development);GO:0042493(BP:response to drug);GO:0071526(BP:semaphorin-plexin signaling pathway);GO:0001756(BP:somitogenesis);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0005887(CC:integral component of plasma membrane);GO:0045499(MF:chemorepellent activity);GO:0038191(MF:neuropilin binding);GO:0030215(MF:semaphorin receptor binding)	hsa04360(Axon guidance)
O95166	1.515793	0.004681368	Gamma-aminobutyric acid receptor-associated protein	11337	GABARAP	GO:0000045(BP:autophagosome assembly);GO:0097352(BP:autophagosome maturation);GO:0000422(BP:autophagy of mitochondrion);GO:0006995(BP:cellular response to nitrogen starvation);GO:0007268(BP:chemical synaptic transmission);GO:0008625(BP:extrinsic apoptotic signaling pathway via death domain receptors);GO:0016236(BP:macroautophagy);GO:0000226(BP:microtubule cytoskeleton organization);GO:0006605(BP:protein targeting);GO:0015629(CC:actin cytoskeleton);GO:0005776(CC:autophagosome);GO:0000421(CC:autophagosome membrane);GO:0005930(CC:axoneme);GO:0044297(CC:cell body);GO:0031410(CC:cytoplasmic vesicle);GO:0005829(CC:cytosol);GO:0000139(CC:Golgi membrane);GO:0005764(CC:lysosome);GO:0005874(CC:microtubule);GO:0005875(CC:microtubule associated complex);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0005790(CC:smooth endoplasmic reticulum);GO:0097225(CC:sperm midpiece);GO:0048487(MF:beta-tubulin binding);GO:0050811(MF:GABA receptor binding);GO:0008017(MF:microtubule binding);GO:0031625(MF:ubiquitin protein ligase binding)	hsa04621(NOD-like receptor signaling pathway);hsa04137(Mitophagy - animal);hsa04136(Autophagy - other);hsa04140(Autophagy - animal);hsa04371(Apelin signaling pathway);hsa05167(Kaposi sarcoma-associated herpesvirus infection);hsa04068(FoxO signaling pathway);hsa04727(GABAergic synapse)
Q24JP5	1.510468	0.00020165	Transmembrane protein 132A	54972	TMEM132A	GO:0044267(BP:cellular protein metabolic process);GO:0043687(BP:post-translational protein modification);GO:0005783(CC:endoplasmic reticulum);GO:0005788(CC:endoplasmic reticulum lumen);GO:0005789(CC:endoplasmic reticulum membrane);GO:0070062(CC:extracellular exosome);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane)	-
P53801	1.507845	0.014989719	Pituitary tumor-transforming gene 1 protein-interacting protein	754	PTTG1IP	"GO:0043518(BP:negative regulation of DNA damage response, signal transduction by p53 class mediator);GO:1902254(BP:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator);GO:1903364(BP:positive regulation of cellular protein catabolic process);GO:0031398(BP:positive regulation of protein ubiquitination);GO:0006606(BP:protein import into nucleus);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0002039(MF:p53 binding)"	-
P04004	1.492922	0.000204192	Vitronectin	7448	VTN	GO:0007155(BP:cell adhesion);GO:0033627(BP:cell adhesion mediated by integrin);GO:0016477(BP:cell migration);GO:0008283(BP:cell proliferation);GO:0007160(BP:cell-matrix adhesion);GO:0035987(BP:endodermal cell differentiation);GO:0030198(BP:extracellular matrix organization);GO:0006955(BP:immune response);GO:0097421(BP:liver regeneration);GO:0030195(BP:negative regulation of blood coagulation);GO:0010951(BP:negative regulation of endopeptidase activity);GO:0048709(BP:oligodendrocyte differentiation);GO:0010811(BP:positive regulation of cell-substrate adhesion);GO:0050731(BP:positive regulation of peptidyl-tyrosine phosphorylation);GO:0032092(BP:positive regulation of protein binding);GO:0048260(BP:positive regulation of receptor-mediated endocytosis);GO:0014911(BP:positive regulation of smooth muscle cell migration);GO:0030949(BP:positive regulation of vascular endothelial growth factor receptor signaling pathway);GO:0090303(BP:positive regulation of wound healing);GO:0051258(BP:protein polymerization);GO:0030449(BP:regulation of complement activation);GO:0061302(BP:smooth muscle cell-matrix adhesion);GO:0071062(CC:alphav-beta3 integrin-vitronectin complex);GO:0005604(CC:basement membrane);GO:0072562(CC:blood microparticle);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005796(CC:Golgi lumen);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0048237(CC:rough endoplasmic reticulum lumen);GO:0005518(MF:collagen binding);GO:0050840(MF:extracellular matrix binding);GO:0005201(MF:extracellular matrix structural constituent);GO:0008201(MF:heparin binding);GO:0042802(MF:identical protein binding);GO:0005178(MF:integrin binding);GO:0030247(MF:polysaccharide binding);GO:0005044(MF:scavenger receptor activity)	hsa04512(ECM-receptor interaction);hsa05165(Human papillomavirus infection);hsa05205(Proteoglycans in cancer);hsa04610(Complement and coagulation cascades);hsa04151(PI3K-Akt signaling pathway);hsa04510(Focal adhesion)
Q12983	1.491533	0.031156322	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	664	BNIP3	GO:0006915(BP:apoptotic process);GO:0048102(BP:autophagic cell death);GO:0000422(BP:autophagy of mitochondrion);GO:0050873(BP:brown fat cell differentiation);GO:0010659(BP:cardiac muscle cell apoptotic process);GO:0008219(BP:cell death);GO:0071279(BP:cellular response to cobalt ion);GO:0070301(BP:cellular response to hydrogen peroxide);GO:0071456(BP:cellular response to hypoxia);GO:0071260(BP:cellular response to mechanical stimulus);GO:0021987(BP:cerebral cortex development);GO:0051607(BP:defense response to virus);GO:0008626(BP:granzyme-mediated apoptotic signaling pathway);GO:1990144(BP:intrinsic apoptotic signaling pathway in response to hypoxia);GO:0043653(BP:mitochondrial fragmentation involved in apoptotic process);GO:0097345(BP:mitochondrial outer membrane permeabilization);GO:0035694(BP:mitochondrial protein catabolic process);GO:0043066(BP:negative regulation of apoptotic process);GO:0060548(BP:negative regulation of cell death);GO:0045837(BP:negative regulation of membrane potential);GO:0010637(BP:negative regulation of mitochondrial fusion);GO:1902109(BP:negative regulation of mitochondrial membrane permeability involved in apoptotic process);GO:0010917(BP:negative regulation of mitochondrial membrane potential);GO:2000378(BP:negative regulation of reactive oxygen species metabolic process);GO:0051402(BP:neuron apoptotic process);GO:0048709(BP:oligodendrocyte differentiation);GO:0043065(BP:positive regulation of apoptotic process);GO:0010508(BP:positive regulation of autophagy);GO:1903599(BP:positive regulation of autophagy of mitochondrion);GO:0010666(BP:positive regulation of cardiac muscle cell apoptotic process);GO:0016239(BP:positive regulation of macroautophagy);GO:0051561(BP:positive regulation of mitochondrial calcium ion concentration);GO:0090141(BP:positive regulation of mitochondrial fission);GO:0010940(BP:positive regulation of necrotic cell death);GO:0043068(BP:positive regulation of programmed cell death);GO:0043243(BP:positive regulation of protein complex disassembly);GO:0090200(BP:positive regulation of release of cytochrome c from mitochondria);GO:0072593(BP:reactive oxygen species metabolic process);GO:1903715(BP:regulation of aerobic respiration);GO:0046902(BP:regulation of mitochondrial membrane permeability);GO:0009617(BP:response to bacterium);GO:0055093(BP:response to hyperoxia);GO:0001666(BP:response to hypoxia);GO:1901998(BP:toxin transport);GO:0016032(BP:viral process);GO:0005737(CC:cytoplasm);GO:0030425(CC:dendrite);GO:0005783(CC:endoplasmic reticulum);GO:0031307(CC:integral component of mitochondrial outer membrane);GO:0031966(CC:mitochondrial membrane);GO:0005741(CC:mitochondrial outer membrane);GO:0005739(CC:mitochondrion);GO:0005635(CC:nuclear envelope);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0014069(CC:postsynaptic density);GO:0051020(MF:GTPase binding);GO:0042802(MF:identical protein binding);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity)	hsa04140(Autophagy - animal);hsa04068(FoxO signaling pathway);hsa05134(Legionellosis);hsa04137(Mitophagy - animal)
Q13751	1.489935	0.001605354	Laminin subunit beta-3	3914	LAMB3	GO:0050873(BP:brown fat cell differentiation);GO:0007155(BP:cell adhesion);GO:0035987(BP:endodermal cell differentiation);GO:0008544(BP:epidermis development);GO:0030198(BP:extracellular matrix organization);GO:0031581(BP:hemidesmosome assembly);GO:0005576(CC:extracellular region);GO:0005610(CC:laminin-5 complex);GO:0005201(MF:extracellular matrix structural constituent);GO:0044877(MF:protein-containing complex binding);GO:0005198(MF:structural molecule activity)	hsa05165(Human papillomavirus infection);hsa05222(Small cell lung cancer);hsa04510(Focal adhesion);hsa05145(Toxoplasmosis);hsa04512(ECM-receptor interaction);hsa05200(Pathways in cancer);hsa04151(PI3K-Akt signaling pathway);hsa05146(Amoebiasis)
P80188	1.485816	0.023984242	Neutrophil gelatinase-associated lipocalin	3934	LCN2	GO:0019730(BP:antimicrobial humoral response);GO:0006879(BP:cellular iron ion homeostasis);GO:0070301(BP:cellular response to hydrogen peroxide);GO:0071347(BP:cellular response to interleukin-1);GO:0071222(BP:cellular response to lipopolysaccharide);GO:0031669(BP:cellular response to nutrient levels);GO:0071356(BP:cellular response to tumor necrosis factor);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0042742(BP:defense response to bacterium);GO:0097192(BP:extrinsic apoptotic signaling pathway in absence of ligand);GO:0045087(BP:innate immune response);GO:0043312(BP:neutrophil degranulation);GO:0031346(BP:positive regulation of cell projection organization);GO:0010628(BP:positive regulation of gene expression);GO:0070207(BP:protein homotrimerization);GO:0009635(BP:response to herbicide);GO:0010046(BP:response to mycotoxin);GO:0009615(BP:response to virus);GO:0097577(BP:sequestering of iron ion);GO:0015891(BP:siderophore transport);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0035580(CC:specific granule lumen);GO:1903981(MF:enterobactin binding);GO:0005506(MF:iron ion binding);GO:0002020(MF:protease binding);GO:0042803(MF:protein homodimerization activity);GO:0036094(MF:small molecule binding)	hsa04657(IL-17 signaling pathway)
P24001	1.484567	0.004708163	Interleukin-32	9235	IL32	GO:0007155(BP:cell adhesion);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0006952(BP:defense response);GO:0006955(BP:immune response);GO:0005829(CC:cytosol);GO:0005615(CC:extracellular space);GO:0016020(CC:membrane);GO:0005125(MF:cytokine activity)	hsa04060(Cytokine-cytokine receptor interaction)
P01023	1.483649	0.042713079	Alpha-2-macroglobulin	2	A2M	"GO:0007597(BP:blood coagulation, intrinsic pathway);GO:0022617(BP:extracellular matrix disassembly);GO:0001869(BP:negative regulation of complement activation, lectin pathway);GO:0002576(BP:platelet degranulation);GO:0051056(BP:regulation of small GTPase mediated signal transduction);GO:0048863(BP:stem cell differentiation);GO:0072562(CC:blood microparticle);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0031093(CC:platelet alpha granule lumen);GO:0048306(MF:calcium-dependent protein binding);GO:0019899(MF:enzyme binding);GO:0019838(MF:growth factor binding);GO:0019966(MF:interleukin-1 binding);GO:0019959(MF:interleukin-8 binding);GO:0002020(MF:protease binding);GO:0004867(MF:serine-type endopeptidase inhibitor activity);GO:0005102(MF:signaling receptor binding);GO:0043120(MF:tumor necrosis factor binding)"	hsa04610(Complement and coagulation cascades)
P02452	1.481551	4.89E-05	Collagen alpha-1(I) chain	1277	COL1A1	"GO:0007596(BP:blood coagulation);GO:0001568(BP:blood vessel development);GO:0060346(BP:bone trabecula formation);GO:0060351(BP:cartilage development involved in endochondral bone morphogenesis);GO:0071230(BP:cellular response to amino acid stimulus);GO:0071364(BP:cellular response to epidermal growth factor stimulus);GO:0044344(BP:cellular response to fibroblast growth factor stimulus);GO:1902618(BP:cellular response to fluoride);GO:0071260(BP:cellular response to mechanical stimulus);GO:0071300(BP:cellular response to retinoic acid);GO:0071560(BP:cellular response to transforming growth factor beta stimulus);GO:0071356(BP:cellular response to tumor necrosis factor);GO:0071306(BP:cellular response to vitamin E);GO:0032964(BP:collagen biosynthetic process);GO:0030199(BP:collagen fibril organization);GO:0038063(BP:collagen-activated tyrosine kinase receptor signaling pathway);GO:0048706(BP:embryonic skeletal system development);GO:0001958(BP:endochondral ossification);GO:0030198(BP:extracellular matrix organization);GO:0060325(BP:face morphogenesis);GO:0001957(BP:intramembranous ossification);GO:0050900(BP:leukocyte migration);GO:0010812(BP:negative regulation of cell-substrate adhesion);GO:0001503(BP:ossification);GO:0001649(BP:osteoblast differentiation);GO:0030168(BP:platelet activation);GO:0090263(BP:positive regulation of canonical Wnt signaling pathway);GO:0030335(BP:positive regulation of cell migration);GO:0010718(BP:positive regulation of epithelial to mesenchymal transition);GO:0045893(BP:positive regulation of transcription, DNA-templated);GO:0070208(BP:protein heterotrimerization);GO:0034504(BP:protein localization to nucleus);GO:0015031(BP:protein transport);GO:0050776(BP:regulation of immune response);GO:0051591(BP:response to cAMP);GO:0031960(BP:response to corticosteroid);GO:0032355(BP:response to estradiol);GO:0042542(BP:response to hydrogen peroxide);GO:0055093(BP:response to hyperoxia);GO:0009612(BP:response to mechanical stimulus);GO:0043434(BP:response to peptide hormone);GO:0007605(BP:sensory perception of sound);GO:0001501(BP:skeletal system development);GO:0043588(BP:skin development);GO:0043589(BP:skin morphogenesis);GO:0044691(BP:tooth eruption);GO:0034505(BP:tooth mineralization);GO:0007601(BP:visual perception);GO:0005584(CC:collagen type I trimer);GO:0005737(CC:cytoplasm);GO:0005788(CC:endoplasmic reticulum lumen);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005794(CC:Golgi apparatus);GO:0030141(CC:secretory granule);GO:0005201(MF:extracellular matrix structural constituent);GO:0030020(MF:extracellular matrix structural constituent conferring tensile strength);GO:0042802(MF:identical protein binding);GO:0046872(MF:metal ion binding);GO:0048407(MF:platelet-derived growth factor binding);GO:0002020(MF:protease binding)"	hsa04510(Focal adhesion);hsa04926(Relaxin signaling pathway);hsa05165(Human papillomavirus infection);hsa05146(Amoebiasis);hsa04151(PI3K-Akt signaling pathway);hsa04611(Platelet activation);hsa04933(AGE-RAGE signaling pathway in diabetic complications);hsa04974(Protein digestion and absorption);hsa04512(ECM-receptor interaction)
Q9P1Z2	1.48023	0.000907507	Calcium-binding and coiled-coil domain-containing protein 1	57658	CALCOCO1	"GO:0030518(BP:intracellular steroid hormone receptor signaling pathway);GO:0010628(BP:positive regulation of gene expression);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0045893(BP:positive regulation of transcription, DNA-templated);GO:0007165(BP:signal transduction);GO:0016055(BP:Wnt signaling pathway);GO:0005829(CC:cytosol);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0000790(CC:nuclear chromatin);GO:0005634(CC:nucleus);GO:0070016(MF:armadillo repeat domain binding);GO:0008013(MF:beta-catenin binding);GO:0003682(MF:chromatin binding);GO:0030374(MF:ligand-dependent nuclear receptor transcription coactivator activity);GO:0008022(MF:protein C-terminus binding);GO:0000980(MF:RNA polymerase II distal enhancer sequence-specific DNA binding);GO:0043565(MF:sequence-specific DNA binding);GO:0003713(MF:transcription coactivator activity);GO:0003712(MF:transcription cofactor activity);GO:0044212(MF:transcription regulatory region DNA binding)"	-
P08962	1.47879	0.003236297	CD63 antigen	967	CD63	"GO:0016477(BP:cell migration);GO:0007166(BP:cell surface receptor signaling pathway);GO:0007160(BP:cell-matrix adhesion);GO:0034613(BP:cellular protein localization);GO:0035646(BP:endosome to melanosome transport);GO:0043312(BP:neutrophil degranulation);GO:0048757(BP:pigment granule maturation);GO:0002576(BP:platelet degranulation);GO:0045807(BP:positive regulation of endocytosis);GO:2001046(BP:positive regulation of integrin-mediated signaling pathway);GO:0002092(BP:positive regulation of receptor internalization);GO:0015031(BP:protein transport);GO:1901379(BP:regulation of potassium ion transmembrane transport);GO:1900746(BP:regulation of vascular endothelial growth factor signaling pathway);GO:0035577(CC:azurophil granule membrane);GO:0009986(CC:cell surface);GO:0031904(CC:endosome lumen);GO:0010008(CC:endosome membrane);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0005887(CC:integral component of plasma membrane);GO:0031226(CC:intrinsic component of plasma membrane);GO:0031902(CC:late endosome membrane);GO:0005765(CC:lysosomal membrane);GO:0042470(CC:melanosome);GO:0032585(CC:multivesicular body membrane);GO:0097487(CC:multivesicular body, internal vesicle);GO:0005886(CC:plasma membrane);GO:0031088(CC:platelet dense granule membrane)"	hsa05205(Proteoglycans in cancer);hsa04142(Lysosome)
O60637	1.472019	0.026428231	Tetraspanin-3	10099	TSPAN3	GO:0007166(BP:cell surface receptor signaling pathway);GO:0070062(CC:extracellular exosome);GO:0005887(CC:integral component of plasma membrane)	-
Q96J84	1.463799	0.008092414	Kin of IRRE-like protein 1	55243	KIRREL1	GO:0098609(BP:cell-cell adhesion);GO:0007588(BP:excretion);GO:0001933(BP:negative regulation of protein phosphorylation);GO:0030838(BP:positive regulation of actin filament polymerization);GO:0031253(CC:cell projection membrane);GO:0005911(CC:cell-cell junction);GO:0043198(CC:dendritic shaft);GO:0016021(CC:integral component of membrane);GO:0045121(CC:membrane raft);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0017022(MF:myosin binding)	-
O95832	1.458674	6.03E-05	Claudin-1	9076	CLDN1	GO:0007568(BP:aging);GO:0070830(BP:bicellular tight junction assembly);GO:0016338(BP:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules);GO:0045216(BP:cell-cell junction organization);GO:1903545(BP:cellular response to butyrate);GO:0071346(BP:cellular response to interferon-gamma);GO:0071284(BP:cellular response to lead ion);GO:0071560(BP:cellular response to transforming growth factor beta stimulus);GO:0071356(BP:cellular response to tumor necrosis factor);GO:0061772(BP:drug transport across blood-nerve barrier);GO:0008065(BP:establishment of blood-nerve barrier);GO:0090557(BP:establishment of endothelial intestinal barrier);GO:0061436(BP:establishment of skin barrier);GO:0042538(BP:hyperosmotic salinity response);GO:0097421(BP:liver regeneration);GO:1903348(BP:positive regulation of bicellular tight junction assembly);GO:0051291(BP:protein heterooligomerization);GO:0051260(BP:protein homooligomerization);GO:0071548(BP:response to dexamethasone);GO:0045471(BP:response to ethanol);GO:0070673(BP:response to interleukin-18);GO:0032496(BP:response to lipopolysaccharide);GO:0016324(CC:apical plasma membrane);GO:0016323(CC:basolateral plasma membrane);GO:0005923(CC:bicellular tight junction);GO:0005737(CC:cytoplasm);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0016328(CC:lateral plasma membrane);GO:0042802(MF:identical protein binding);GO:0005198(MF:structural molecule activity);GO:0001618(MF:virus receptor activity)	hsa05160(Hepatitis C);hsa05130(Pathogenic Escherichia coli infection);hsa04514(Cell adhesion molecules (CAMs));hsa04670(Leukocyte transendothelial migration);hsa04530(Tight junction)
Q92626	1.458316	1.01E-05	Peroxidasin homolog	7837	PXDN	GO:0030198(BP:extracellular matrix organization);GO:0042744(BP:hydrogen peroxide catabolic process);GO:0006955(BP:immune response);GO:0055114(BP:oxidation-reduction process);GO:0006979(BP:response to oxidative stress);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005201(MF:extracellular matrix structural constituent);GO:0020037(MF:heme binding);GO:0005152(MF:interleukin-1 receptor antagonist activity);GO:0046872(MF:metal ion binding);GO:0004601(MF:peroxidase activity)	-
A6NCE7	1.457443	0.001154951	Microtubule-associated proteins 1A/1B light chain 3 beta 2	643246	MAP1LC3B2	GO:0000045(BP:autophagosome assembly);GO:0000422(BP:autophagy of mitochondrion);GO:0006995(BP:cellular response to nitrogen starvation);GO:0000421(CC:autophagosome membrane);GO:0031410(CC:cytoplasmic vesicle);GO:0005829(CC:cytosol);GO:0012505(CC:endomembrane system);GO:0005874(CC:microtubule);GO:0008017(MF:microtubule binding)	-
Q9UBM7	1.451783	0.040148566	7-dehydrocholesterol reductase	1717	DHCR7	GO:0001568(BP:blood vessel development);GO:0016132(BP:brassinosteroid biosynthetic process);GO:0030154(BP:cell differentiation);GO:0006695(BP:cholesterol biosynthetic process);GO:0033489(BP:cholesterol biosynthetic process via desmosterol);GO:0033490(BP:cholesterol biosynthetic process via lathosterol);GO:0030324(BP:lung development);GO:0035264(BP:multicellular organism growth);GO:0009791(BP:post-embryonic development);GO:0042127(BP:regulation of cell proliferation);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0016126(BP:sterol biosynthetic process);GO:0005829(CC:cytosol);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0030176(CC:integral component of endoplasmic reticulum membrane);GO:0016020(CC:membrane);GO:0005640(CC:nuclear outer membrane);GO:0047598(MF:7-dehydrocholesterol reductase activity);GO:0050661(MF:NADP binding);GO:0009918(MF:sterol delta7 reductase activity)	hsa00100(Steroid biosynthesis)
P00488	1.45144	0.037770198	Coagulation factor XIII A chain	2162	F13A1	"GO:0007596(BP:blood coagulation);GO:0072378(BP:blood coagulation, fibrin clot formation);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0018149(BP:peptide cross-linking);GO:0002576(BP:platelet degranulation);GO:0072562(CC:blood microparticle);GO:0005576(CC:extracellular region);GO:0031093(CC:platelet alpha granule lumen);GO:0046872(MF:metal ion binding);GO:0003810(MF:protein-glutamine gamma-glutamyltransferase activity)"	hsa04610(Complement and coagulation cascades)
O14798	1.450104	0.0018361	Tumor necrosis factor receptor superfamily member 10C	8794	TNFRSF10C	GO:0043065(BP:positive regulation of apoptotic process);GO:0042981(BP:regulation of apoptotic process);GO:0036462(BP:TRAIL-activated apoptotic signaling pathway);GO:0031225(CC:anchored component of membrane);GO:0009986(CC:cell surface);GO:0005886(CC:plasma membrane);GO:0045569(MF:TRAIL binding);GO:0004888(MF:transmembrane signaling receptor activity)	hsa04060(Cytokine-cytokine receptor interaction)
Q9UHI8	1.446293	0.000474663	A disintegrin and metalloproteinase with thrombospondin motifs 1	9510	ADAMTS1	GO:0060347(BP:heart trabecula formation);GO:0007229(BP:integrin-mediated signaling pathway);GO:0001822(BP:kidney development);GO:0008285(BP:negative regulation of cell proliferation);GO:0001542(BP:ovulation from ovarian follicle);GO:1900087(BP:positive regulation of G1/S transition of mitotic cell cycle);GO:1904754(BP:positive regulation of vascular associated smooth muscle cell migration);GO:1904707(BP:positive regulation of vascular smooth muscle cell proliferation);GO:0005604(CC:basement membrane);GO:0031410(CC:cytoplasmic vesicle);GO:0008201(MF:heparin binding);GO:0004222(MF:metalloendopeptidase activity);GO:0008237(MF:metallopeptidase activity);GO:0008270(MF:zinc ion binding)	-
P09341	1.441404	0.000103185	Growth-regulated alpha protein	2919	CXCL1	GO:0030036(BP:actin cytoskeleton organization);GO:0061844(BP:antimicrobial humoral immune response mediated by antimicrobial peptide);GO:0008283(BP:cell proliferation);GO:0071222(BP:cellular response to lipopolysaccharide);GO:0070098(BP:chemokine-mediated signaling pathway);GO:0006935(BP:chemotaxis);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0006955(BP:immune response);GO:0006954(BP:inflammatory response);GO:0035556(BP:intracellular signal transduction);GO:0031640(BP:killing of cells of other organism);GO:0030595(BP:leukocyte chemotaxis);GO:0008285(BP:negative regulation of cell proliferation);GO:0007399(BP:nervous system development);GO:0030593(BP:neutrophil chemotaxis);GO:0043312(BP:neutrophil degranulation);GO:0007165(BP:signal transduction);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0035580(CC:specific granule lumen);GO:1904724(CC:tertiary granule lumen);GO:0008009(MF:chemokine activity);GO:0008047(MF:enzyme activator activity);GO:0008083(MF:growth factor activity);GO:0005102(MF:signaling receptor binding)	hsa04657(IL-17 signaling pathway);hsa05323(Rheumatoid arthritis);hsa05120(Epithelial cell signaling in Helicobacter pylori infection);hsa04621(NOD-like receptor signaling pathway);hsa04060(Cytokine-cytokine receptor interaction);hsa05146(Amoebiasis);hsa05132(Salmonella infection);hsa05134(Legionellosis);hsa04062(Chemokine signaling pathway);hsa04668(TNF signaling pathway);hsa05167(Kaposi sarcoma-associated herpesvirus infection)
P69905	1.440967	0.016473479	Hemoglobin subunit alpha	3039	HBA1	GO:0015701(BP:bicarbonate transport);GO:0098869(BP:cellular oxidant detoxification);GO:0042744(BP:hydrogen peroxide catabolic process);GO:0015671(BP:oxygen transport);GO:0010942(BP:positive regulation of cell death);GO:0051291(BP:protein heterooligomerization);GO:0006898(BP:receptor-mediated endocytosis);GO:0042542(BP:response to hydrogen peroxide);GO:0072562(CC:blood microparticle);GO:0005829(CC:cytosol);GO:0022627(CC:cytosolic small ribosomal subunit);GO:0071682(CC:endocytic vesicle lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0031838(CC:haptoglobin-hemoglobin complex);GO:0005833(CC:hemoglobin complex);GO:0016020(CC:membrane);GO:0020037(MF:heme binding);GO:0005506(MF:iron ion binding);GO:0043177(MF:organic acid binding);GO:0019825(MF:oxygen binding);GO:0005344(MF:oxygen carrier activity)	hsa05144(Malaria);hsa05143(African trypanosomiasis)
P50591	1.436444	0.013587124	Tumor necrosis factor ligand superfamily member 10	8743	TNFSF10	GO:0006919(BP:activation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0006915(BP:apoptotic process);GO:0007166(BP:cell surface receptor signaling pathway);GO:0007267(BP:cell-cell signaling);GO:0006955(BP:immune response);GO:0008584(BP:male gonad development);GO:1902042(BP:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors);GO:0043065(BP:positive regulation of apoptotic process);GO:0043280(BP:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:2001238(BP:positive regulation of extrinsic apoptotic signaling pathway);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0090200(BP:positive regulation of release of cytochrome c from mitochondria);GO:1902041(BP:regulation of extrinsic apoptotic signaling pathway via death domain receptors);GO:0032868(BP:response to insulin);GO:0007165(BP:signal transduction);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005887(CC:integral component of plasma membrane);GO:0005125(MF:cytokine activity);GO:0042802(MF:identical protein binding);GO:0005102(MF:signaling receptor binding);GO:0045569(MF:TRAIL binding);GO:0005164(MF:tumor necrosis factor receptor binding);GO:0008270(MF:zinc ion binding)	hsa04650(Natural killer cell mediated cytotoxicity);hsa04217(Necroptosis);hsa04060(Cytokine-cytokine receptor interaction);hsa05164(Influenza A);hsa04210(Apoptosis);hsa05162(Measles);hsa04068(FoxO signaling pathway)
Q8NG11	1.4248	0.000236132	Tetraspanin-14	81619	TSPAN14	GO:0007166(BP:cell surface receptor signaling pathway);GO:0044267(BP:cellular protein metabolic process);GO:0043312(BP:neutrophil degranulation);GO:0045747(BP:positive regulation of Notch signaling pathway);GO:0072659(BP:protein localization to plasma membrane);GO:0051604(BP:protein maturation);GO:0009986(CC:cell surface);GO:0005788(CC:endoplasmic reticulum lumen);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0035579(CC:specific granule membrane);GO:0070821(CC:tertiary granule membrane);GO:0097197(CC:tetraspanin-enriched microdomain);GO:0019899(MF:enzyme binding)	-
Q8NBZ7	1.422764	0.000803229	UDP-glucuronic acid decarboxylase 1	80146	UXS1	GO:0051262(BP:protein tetramerization);GO:0033320(BP:UDP-D-xylose biosynthetic process);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0032580(CC:Golgi cisterna membrane);GO:0016021(CC:integral component of membrane);GO:0070403(MF:NAD+ binding);GO:0042803(MF:protein homodimerization activity);GO:0048040(MF:UDP-glucuronate decarboxylase activity)	hsa00520(Amino sugar and nucleotide sugar metabolism)
O95297	1.418312	0.000920005	Myelin protein zero-like protein 1	9019	MPZL1	GO:0007267(BP:cell-cell signaling);GO:0007169(BP:transmembrane receptor protein tyrosine kinase signaling pathway);GO:0009986(CC:cell surface);GO:0005925(CC:focal adhesion);GO:0005887(CC:integral component of plasma membrane);GO:0005198(MF:structural molecule activity)	hsa04514(Cell adhesion molecules (CAMs))
P08648	1.415791	0.001883331	Integrin alpha-5	3678	ITGA5	"GO:0001525(BP:angiogenesis);GO:0007155(BP:cell adhesion);GO:0033627(BP:cell adhesion mediated by integrin);GO:0033631(BP:cell-cell adhesion mediated by integrin);GO:0031589(BP:cell-substrate adhesion);GO:0007044(BP:cell-substrate junction assembly);GO:0035987(BP:endodermal cell differentiation);GO:0030198(BP:extracellular matrix organization);GO:0007565(BP:female pregnancy);GO:0007157(BP:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules);GO:0034113(BP:heterotypic cell-cell adhesion);GO:0007229(BP:integrin-mediated signaling pathway);GO:0007159(BP:leukocyte cell-cell adhesion);GO:0050900(BP:leukocyte migration);GO:0007613(BP:memory);GO:2000811(BP:negative regulation of anoikis);GO:0030335(BP:positive regulation of cell migration);GO:0010811(BP:positive regulation of cell-substrate adhesion);GO:0050731(BP:positive regulation of peptidyl-tyrosine phosphorylation);GO:1903672(BP:positive regulation of sprouting angiogenesis);GO:0030949(BP:positive regulation of vascular endothelial growth factor receptor signaling pathway);GO:0035313(BP:wound healing, spreading of epidermal cells);GO:0071062(CC:alphav-beta3 integrin-vitronectin complex);GO:0009986(CC:cell surface);GO:0031410(CC:cytoplasmic vesicle);GO:0005783(CC:endoplasmic reticulum);GO:0009897(CC:external side of plasma membrane);GO:0005925(CC:focal adhesion);GO:0005794(CC:Golgi apparatus);GO:0008305(CC:integrin complex);GO:0005886(CC:plasma membrane);GO:0001726(CC:ruffle);GO:0045202(CC:synapse);GO:0005154(MF:epidermal growth factor receptor binding);GO:0005178(MF:integrin binding);GO:0046872(MF:metal ion binding);GO:0005161(MF:platelet-derived growth factor receptor binding);GO:0043184(MF:vascular endothelial growth factor receptor 2 binding);GO:0001618(MF:virus receptor activity)"	hsa04512(ECM-receptor interaction);hsa05206(MicroRNAs in cancer);hsa05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));hsa05414(Dilated cardiomyopathy (DCM));hsa04151(PI3K-Akt signaling pathway);hsa04640(Hematopoietic cell lineage);hsa04810(Regulation of actin cytoskeleton);hsa05165(Human papillomavirus infection);hsa05205(Proteoglycans in cancer);hsa05100(Bacterial invasion of epithelial cells);hsa04145(Phagosome);hsa05133(Pertussis);hsa05131(Shigellosis);hsa05410(Hypertrophic cardiomyopathy (HCM));hsa04510(Focal adhesion)
Q9NV92	1.415191	0.002131435	NEDD4 family-interacting protein 2	54602	NDFIP2	GO:0030001(BP:metal ion transport);GO:0010629(BP:negative regulation of gene expression);GO:0051224(BP:negative regulation of protein transport);GO:0032410(BP:negative regulation of transporter activity);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0031398(BP:positive regulation of protein ubiquitination);GO:0007034(BP:vacuolar transport);GO:0005737(CC:cytoplasm);GO:0005783(CC:endoplasmic reticulum);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005739(CC:mitochondrion);GO:0032585(CC:multivesicular body membrane);GO:0048471(CC:perinuclear region of cytoplasm);GO:0050699(MF:WW domain binding)	-
O75976	1.404103	0.002004569	Carboxypeptidase D	1362	CPD	GO:0006518(BP:peptide metabolic process);GO:0016485(BP:protein processing);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0004181(MF:metallocarboxypeptidase activity);GO:0004185(MF:serine-type carboxypeptidase activity);GO:0008270(MF:zinc ion binding)	-
P00734	1.400401	0.0018523	Prothrombin	2147	F2	"GO:0006953(BP:acute-phase response);GO:0061844(BP:antimicrobial humoral immune response mediated by antimicrobial peptide);GO:0007596(BP:blood coagulation);GO:0007597(BP:blood coagulation, intrinsic pathway);GO:0007166(BP:cell surface receptor signaling pathway);GO:0044267(BP:cellular protein metabolic process);GO:0051838(BP:cytolysis by host of symbiont cells);GO:0006888(BP:ER to Golgi vesicle-mediated transport);GO:0042730(BP:fibrinolysis);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0050900(BP:leukocyte migration);GO:0007275(BP:multicellular organism development);GO:0048712(BP:negative regulation of astrocyte differentiation);GO:1900016(BP:negative regulation of cytokine production involved in inflammatory response);GO:0051918(BP:negative regulation of fibrinolysis);GO:0010544(BP:negative regulation of platelet activation);GO:0045861(BP:negative regulation of proteolysis);GO:0070945(BP:neutrophil mediated killing of gram-negative bacterium);GO:0030168(BP:platelet activation);GO:0030194(BP:positive regulation of blood coagulation);GO:0030307(BP:positive regulation of cell growth);GO:0008284(BP:positive regulation of cell proliferation);GO:0032967(BP:positive regulation of collagen biosynthetic process);GO:0090218(BP:positive regulation of lipid kinase activity);GO:0014068(BP:positive regulation of phosphatidylinositol 3-kinase signaling);GO:1900738(BP:positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway);GO:1900182(BP:positive regulation of protein localization to nucleus);GO:0001934(BP:positive regulation of protein phosphorylation);GO:2000379(BP:positive regulation of reactive oxygen species metabolic process);GO:0046427(BP:positive regulation of JAK-STAT cascade);GO:0051281(BP:positive regulation of release of sequestered calcium ion into cytosol);GO:0006508(BP:proteolysis);GO:0030193(BP:regulation of blood coagulation);GO:0008360(BP:regulation of cell shape);GO:0030449(BP:regulation of complement activation);GO:0051480(BP:regulation of cytosolic calcium ion concentration);GO:0010468(BP:regulation of gene expression);GO:0009611(BP:response to wounding);GO:0072562(CC:blood microparticle);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005796(CC:Golgi lumen);GO:0005886(CC:plasma membrane);GO:0005509(MF:calcium ion binding);GO:0008047(MF:enzyme activator activity);GO:0008083(MF:growth factor activity);GO:0008201(MF:heparin binding);GO:0001530(MF:lipopolysaccharide binding);GO:0004252(MF:serine-type endopeptidase activity);GO:0005102(MF:signaling receptor binding);GO:0070053(MF:thrombospondin receptor activity)"	hsa04810(Regulation of actin cytoskeleton);hsa04610(Complement and coagulation cascades);hsa04080(Neuroactive ligand-receptor interaction)
Q96CS7	1.3913	0.008052432	Pleckstrin homology domain-containing family B member 2	55041	PLEKHB2	"GO:0045595(BP:regulation of cell differentiation);GO:0016021(CC:integral component of membrane);GO:0055038(CC:recycling endosome membrane);GO:0005547(MF:phosphatidylinositol-3,4,5-trisphosphate binding)"	-
O60353	1.379554	8.22E-05	Frizzled-6	8323	FZD6	"GO:0060070(BP:canonical Wnt signaling pathway);GO:0033278(BP:cell proliferation in midbrain);GO:0035880(BP:embryonic nail plate morphogenesis);GO:0048105(BP:establishment of body hair planar orientation);GO:0001942(BP:hair follicle development);GO:0042472(BP:inner ear morphogenesis);GO:1904693(BP:midbrain morphogenesis);GO:0090090(BP:negative regulation of canonical Wnt signaling pathway);GO:0043433(BP:negative regulation of DNA binding transcription factor activity);GO:0001843(BP:neural tube closure);GO:0035567(BP:non-canonical Wnt signaling pathway);GO:0030168(BP:platelet activation);GO:0007223(BP:Wnt signaling pathway, calcium modulating pathway);GO:0060071(BP:Wnt signaling pathway, planar cell polarity pathway);GO:0016324(CC:apical plasma membrane);GO:0016327(CC:apicolateral plasma membrane);GO:0009986(CC:cell surface);GO:0030659(CC:cytoplasmic vesicle membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0004930(MF:G-protein coupled receptor activity);GO:0031625(MF:ubiquitin protein ligase binding);GO:0042813(MF:Wnt-activated receptor activity);GO:0017147(MF:Wnt-protein binding)"	hsa05226(Gastric cancer);hsa05166(Human T-cell leukemia virus 1 infection);hsa04390(Hippo signaling pathway);hsa05225(Hepatocellular carcinoma);hsa05217(Basal cell carcinoma);hsa05200(Pathways in cancer);hsa04916(Melanogenesis);hsa04550(Signaling pathways regulating pluripotency of stem cells);hsa04310(Wnt signaling pathway);hsa04934(Cushing syndrome);hsa04150(mTOR signaling pathway);hsa05224(Breast cancer);hsa05165(Human papillomavirus infection);hsa05205(Proteoglycans in cancer)
P52657	1.376667	0.002915145	Transcription initiation factor IIA subunit 2	2958	GTF2A2	GO:0051091(BP:positive regulation of DNA binding transcription factor activity);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0051123(BP:RNA polymerase II transcriptional preinitiation complex assembly);GO:0042795(BP:snRNA transcription by RNA polymerase II);GO:0006366(BP:transcription by RNA polymerase II);GO:0006367(BP:transcription initiation from RNA polymerase II promoter);GO:0016032(BP:viral process);GO:0030054(CC:cell junction);GO:0005654(CC:nucleoplasm);GO:0005672(CC:transcription factor TFIIA complex);GO:0005669(CC:transcription factor TFIID complex);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity);GO:0001103(MF:RNA polymerase II repressing transcription factor binding);GO:0017025(MF:TBP-class protein binding);GO:0003713(MF:transcription coactivator activity);GO:0008134(MF:transcription factor binding)	hsa03022(Basal transcription factors);hsa05203(Viral carcinogenesis)
P37268	1.373741	0.006837952	Squalene synthase	2222	FDFT1	GO:0006695(BP:cholesterol biosynthetic process);GO:0006696(BP:ergosterol biosynthetic process);GO:0045338(BP:farnesyl diphosphate metabolic process);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0019216(BP:regulation of lipid metabolic process);GO:0006694(BP:steroid biosynthetic process);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0004310(MF:farnesyl-diphosphate farnesyltransferase activity);GO:0046872(MF:metal ion binding);GO:0051996(MF:squalene synthase activity)	hsa00100(Steroid biosynthesis)
P10586	1.36965	0.000644028	Receptor-type tyrosine-protein phosphatase F	5792	PTPRF	GO:0007155(BP:cell adhesion);GO:0016477(BP:cell migration);GO:1900121(BP:negative regulation of receptor binding);GO:0031102(BP:neuron projection regeneration);GO:0035335(BP:peptidyl-tyrosine dephosphorylation);GO:0048679(BP:regulation of axon regeneration);GO:0099560(BP:synaptic membrane adhesion);GO:0007185(BP:transmembrane receptor protein tyrosine phosphatase signaling pathway);GO:0070062(CC:extracellular exosome);GO:0005887(CC:integral component of plasma membrane);GO:0043005(CC:neuron projection);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0050839(MF:cell adhesion molecule binding);GO:0035373(MF:chondroitin sulfate proteoglycan binding);GO:0008201(MF:heparin binding);GO:0004725(MF:protein tyrosine phosphatase activity);GO:0044877(MF:protein-containing complex binding);GO:0005001(MF:transmembrane receptor protein tyrosine phosphatase activity)	hsa04520(Adherens junction);hsa04910(Insulin signaling pathway);hsa04931(Insulin resistance);hsa04514(Cell adhesion molecules (CAMs))
O14786	1.369146	0.005622153	Neuropilin-1	8829	NRP1	"GO:0031532(BP:actin cytoskeleton reorganization);GO:0001525(BP:angiogenesis);GO:0060978(BP:angiogenesis involved in coronary vascular morphogenesis);GO:0009887(BP:animal organ morphogenesis);GO:0048844(BP:artery morphogenesis);GO:0048846(BP:axon extension involved in axon guidance);GO:0007411(BP:axon guidance);GO:0007413(BP:axonal fasciculation);GO:0060385(BP:axonogenesis involved in innervation);GO:0150020(BP:basal dendrite arborization);GO:0150018(BP:basal dendrite development);GO:0001569(BP:branching involved in blood vessel morphogenesis);GO:0021785(BP:branchiomotor neuron axon guidance);GO:0002042(BP:cell migration involved in sprouting angiogenesis);GO:0007267(BP:cell-cell signaling);GO:0035729(BP:cellular response to hepatocyte growth factor stimulus);GO:0035924(BP:cellular response to vascular endothelial growth factor stimulus);GO:0071679(BP:commissural neuron axon guidance);GO:0060982(BP:coronary artery morphogenesis);GO:0060666(BP:dichotomous subdivision of terminal units involved in salivary gland branching);GO:1904835(BP:dorsal root ganglion morphogenesis);GO:0035767(BP:endothelial cell chemotaxis);GO:0043542(BP:endothelial cell migration);GO:0097102(BP:endothelial tip cell fate specification);GO:0021612(BP:facial nerve structural organization);GO:1903375(BP:facioacoustic ganglion development);GO:0021828(BP:gonadotrophin-releasing hormone neuronal migration to the hypothalamus);GO:0048012(BP:hepatocyte growth factor receptor signaling pathway);GO:0007229(BP:integrin-mediated signaling pathway);GO:0097475(BP:motor neuron migration);GO:0048843(BP:negative regulation of axon extension involved in axon guidance);GO:2001237(BP:negative regulation of extrinsic apoptotic signaling pathway);GO:0043524(BP:negative regulation of neuron apoptotic process);GO:0021675(BP:nerve development);GO:1901166(BP:neural crest cell migration involved in autonomic nervous system development);GO:0001764(BP:neuron migration);GO:0038189(BP:neuropilin signaling pathway);GO:1905040(BP:otic placode development);GO:0003148(BP:outflow tract septum morphogenesis);GO:0048008(BP:platelet-derived growth factor receptor signaling pathway);GO:0050918(BP:positive chemotaxis);GO:2000251(BP:positive regulation of actin cytoskeleton reorganization);GO:0048842(BP:positive regulation of axon extension involved in axon guidance);GO:0090050(BP:positive regulation of cell migration involved in sprouting angiogenesis);GO:0060301(BP:positive regulation of cytokine activity);GO:0010595(BP:positive regulation of endothelial cell migration);GO:0001938(BP:positive regulation of endothelial cell proliferation);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:0051491(BP:positive regulation of filopodium assembly);GO:0051894(BP:positive regulation of focal adhesion assembly);GO:0050731(BP:positive regulation of peptidyl-tyrosine phosphorylation);GO:0042327(BP:positive regulation of phosphorylation);GO:1902336(BP:positive regulation of retinal ganglion cell axon guidance);GO:0014911(BP:positive regulation of smooth muscle cell migration);GO:0051496(BP:positive regulation of stress fiber assembly);GO:1900026(BP:positive regulation of substrate adhesion-dependent cell spreading);GO:0099173(BP:postsynapse organization);GO:1902946(BP:protein localization to early endosome);GO:0032489(BP:regulation of Cdc42 protein signal transduction);GO:0090259(BP:regulation of retinal ganglion cell axon guidance);GO:0060627(BP:regulation of vesicle-mediated transport);GO:0061441(BP:renal artery morphogenesis);GO:0009611(BP:response to wounding);GO:0061299(BP:retina vasculature morphogenesis in camera-type eye);GO:0031290(BP:retinal ganglion cell axon guidance);GO:0071526(BP:semaphorin-plexin signaling pathway);GO:1902287(BP:semaphorin-plexin signaling pathway involved in axon guidance);GO:1902285(BP:semaphorin-plexin signaling pathway involved in neuron projection guidance);GO:0097374(BP:sensory neuron axon guidance);GO:0007165(BP:signal transduction);GO:0002040(BP:sprouting angiogenesis);GO:0034446(BP:substrate adhesion-dependent cell spreading);GO:0006930(BP:substrate-dependent cell migration, cell extension);GO:0061549(BP:sympathetic ganglion development);GO:0097490(BP:sympathetic neuron projection extension);GO:0097491(BP:sympathetic neuron projection guidance);GO:1901998(BP:toxin transport);GO:0061551(BP:trigeminal ganglion development);GO:0021637(BP:trigeminal nerve structural organization);GO:0048010(BP:vascular endothelial growth factor receptor signaling pathway);GO:0038190(BP:VEGF-activated neuropilin signaling pathway);GO:1902378(BP:VEGF-activated neuropilin signaling pathway involved in axon guidance);GO:0036486(BP:ventral trunk neural crest cell migration);GO:0021649(BP:vestibulocochlear nerve structural organization);GO:0030424(CC:axon);GO:0009986(CC:cell surface);GO:0031410(CC:cytoplasmic vesicle);GO:0005829(CC:cytosol);GO:0005769(CC:early endosome);GO:0005615(CC:extracellular space);GO:0005925(CC:focal adhesion);GO:0098978(CC:glutamatergic synapse);GO:0030426(CC:growth cone);GO:0099055(CC:integral component of postsynaptic membrane);GO:0005883(CC:neurofilament);GO:0043005(CC:neuron projection);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0043235(CC:receptor complex);GO:0002116(CC:semaphorin receptor complex);GO:0097443(CC:sorting endosome);GO:0015026(MF:coreceptor activity);GO:0019955(MF:cytokine binding);GO:0019838(MF:growth factor binding);GO:0005096(MF:GTPase activator activity);GO:0008201(MF:heparin binding);GO:0046872(MF:metal ion binding);GO:0019901(MF:protein kinase binding);GO:0017154(MF:semaphorin receptor activity);GO:0038085(MF:vascular endothelial growth factor binding);GO:0005021(MF:vascular endothelial growth factor-activated receptor activity)"	hsa04360(Axon guidance);hsa05166(Human T-cell leukemia virus 1 infection)
P40189	1.365976	0.00278587	Interleukin-6 receptor subunit beta	3572	IL6ST	GO:0070120(BP:ciliary neurotrophic factor-mediated signaling pathway);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0005977(BP:glycogen metabolic process);GO:0070106(BP:interleukin-27-mediated signaling pathway);GO:0070757(BP:interleukin-35-mediated signaling pathway);GO:0070102(BP:interleukin-6-mediated signaling pathway);GO:0048861(BP:leukemia inhibitory factor signaling pathway);GO:0043066(BP:negative regulation of apoptotic process);GO:0070104(BP:negative regulation of interleukin-6-mediated signaling pathway);GO:0038165(BP:oncostatin-M-mediated signaling pathway);GO:0002675(BP:positive regulation of acute inflammatory response);GO:0002821(BP:positive regulation of adaptive immune response);GO:0048711(BP:positive regulation of astrocyte differentiation);GO:0010613(BP:positive regulation of cardiac muscle hypertrophy);GO:0008284(BP:positive regulation of cell proliferation);GO:0045669(BP:positive regulation of osteoblast differentiation);GO:0042102(BP:positive regulation of T cell proliferation);GO:0042531(BP:positive regulation of tyrosine phosphorylation of STAT protein);GO:0010575(BP:positive regulation of vascular endothelial growth factor production);GO:0008593(BP:regulation of Notch signaling pathway);GO:0034097(BP:response to cytokine);GO:0016032(BP:viral process);GO:0070110(CC:ciliary neurotrophic factor receptor complex);GO:0030425(CC:dendrite);GO:0009897(CC:external side of plasma membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005896(CC:interleukin-6 receptor complex);GO:0016020(CC:membrane);GO:0043025(CC:neuronal cell body);GO:0005900(CC:oncostatin-M receptor complex);GO:0005886(CC:plasma membrane);GO:0043235(CC:receptor complex);GO:0004897(MF:ciliary neurotrophic factor receptor activity);GO:0005127(MF:ciliary neurotrophic factor receptor binding);GO:0019955(MF:cytokine binding);GO:0004896(MF:cytokine receptor activity);GO:0019838(MF:growth factor binding);GO:0042802(MF:identical protein binding);GO:0019970(MF:interleukin-11 binding);GO:0004921(MF:interleukin-11 receptor activity);GO:0045509(MF:interleukin-27 receptor activity);GO:0042803(MF:protein homodimerization activity)	hsa04060(Cytokine-cytokine receptor interaction);hsa04659(Th17 cell differentiation);hsa05203(Viral carcinogenesis);hsa04550(Signaling pathways regulating pluripotency of stem cells);hsa05167(Kaposi sarcoma-associated herpesvirus infection);hsa04630(Jak-STAT signaling pathway);hsa05200(Pathways in cancer)
Q99988	1.355128	0.00549366	Growth/differentiation factor 15	9518	GDF15	GO:0000187(BP:activation of MAPK activity);GO:0030509(BP:BMP signaling pathway);GO:0048468(BP:cell development);GO:0007267(BP:cell-cell signaling);GO:0035860(BP:glial cell-derived neurotrophic factor receptor signaling pathway);GO:0060400(BP:negative regulation of growth hormone receptor signaling pathway);GO:0040015(BP:negative regulation of multicellular organism growth);GO:0043410(BP:positive regulation of MAPK cascade);GO:1901741(BP:positive regulation of myoblast fusion);GO:0010862(BP:positive regulation of pathway-restricted SMAD protein phosphorylation);GO:0051897(BP:positive regulation of protein kinase B signaling);GO:0002023(BP:reduction of food intake in response to dietary excess);GO:0042981(BP:regulation of apoptotic process);GO:0043408(BP:regulation of MAPK cascade);GO:0007165(BP:signal transduction);GO:0060395(BP:SMAD protein signal transduction);GO:0007179(BP:transforming growth factor beta receptor signaling pathway);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005794(CC:Golgi apparatus);GO:0005634(CC:nucleus);GO:0005125(MF:cytokine activity);GO:0008083(MF:growth factor activity);GO:0042803(MF:protein homodimerization activity);GO:0005160(MF:transforming growth factor beta receptor binding)	hsa04060(Cytokine-cytokine receptor interaction)
P19021	1.351201	0.015652215	Peptidyl-glycine alpha-amidating monooxygenase	5066	PAM	GO:0007417(BP:central nervous system development);GO:0007507(BP:heart development);GO:0007595(BP:lactation);GO:0060173(BP:limb development);GO:0001676(BP:long-chain fatty acid metabolic process);GO:0060135(BP:maternal process involved in female pregnancy);GO:0042476(BP:odontogenesis);GO:0022602(BP:ovulation cycle process);GO:0001519(BP:peptide amidation);GO:0018032(BP:protein amidation);GO:0051260(BP:protein homooligomerization);GO:0032956(BP:regulation of actin cytoskeleton organization);GO:0050708(BP:regulation of protein secretion);GO:0006357(BP:regulation of transcription by RNA polymerase II);GO:0046688(BP:response to copper ion);GO:0042493(BP:response to drug);GO:0032355(BP:response to estradiol);GO:0051384(BP:response to glucocorticoid);GO:0001666(BP:response to hypoxia);GO:0009268(BP:response to pH);GO:0009404(BP:toxin metabolic process);GO:0009986(CC:cell surface);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0043005(CC:neuron projection);GO:0043204(CC:perikaryon);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0030667(CC:secretory granule membrane);GO:0005802(CC:trans-Golgi network);GO:0030658(CC:transport vesicle membrane);GO:0005509(MF:calcium ion binding);GO:0005507(MF:copper ion binding);GO:0031418(MF:L-ascorbic acid binding);GO:0004598(MF:peptidylamidoglycolate lyase activity);GO:0004504(MF:peptidylglycine monooxygenase activity);GO:0019901(MF:protein kinase binding);GO:0008270(MF:zinc ion binding)	-
Q9UJG1	1.349635	0.016311466	Motile sperm domain-containing protein 1	56180	MOSPD1	GO:0030154(BP:cell differentiation);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0005737(CC:cytoplasm);GO:0005789(CC:endoplasmic reticulum membrane);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane);GO:0005634(CC:nucleus);GO:0048471(CC:perinuclear region of cytoplasm)	-
Q9H2H9	1.349434	0.002476175	Sodium-coupled neutral amino acid transporter 1	81539	SLC38A1	GO:0003333(BP:amino acid transmembrane transport);GO:0006865(BP:amino acid transport);GO:0001504(BP:neurotransmitter uptake);GO:0015804(BP:neutral amino acid transport);GO:0070062(CC:extracellular exosome);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0015171(MF:amino acid transmembrane transporter activity);GO:0005283(MF:amino acid:sodium symporter activity);GO:0015179(MF:L-amino acid transmembrane transporter activity);GO:0015175(MF:neutral amino acid transmembrane transporter activity)	hsa04724(Glutamatergic synapse);hsa04727(GABAergic synapse)
O00300	1.346499	0.011543522	Tumor necrosis factor receptor superfamily member 11B	4982	TNFRSF11B	GO:0006915(BP:apoptotic process);GO:0030198(BP:extracellular matrix organization);GO:0045779(BP:negative regulation of bone resorption);GO:0042489(BP:negative regulation of odontogenesis of dentin-containing tooth);GO:0046685(BP:response to arsenic-containing substance);GO:0042493(BP:response to drug);GO:0043627(BP:response to estrogen);GO:0032026(BP:response to magnesium ion);GO:0007584(BP:response to nutrient);GO:0007165(BP:signal transduction);GO:0001501(BP:skeletal system development);GO:0033209(BP:tumor necrosis factor-mediated signaling pathway);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005886(CC:plasma membrane);GO:0005125(MF:cytokine activity);GO:0038023(MF:signaling receptor activity)	hsa04380(Osteoclast differentiation);hsa04060(Cytokine-cytokine receptor interaction)
P34096	1.342602	0.007291116	Ribonuclease 4	6038	RNASE4	GO:0006379(BP:mRNA cleavage);GO:0005576(CC:extracellular region);GO:0003676(MF:nucleic acid binding);GO:0004522(MF:ribonuclease A activity);GO:0004540(MF:ribonuclease activity)	-
P31431	1.34249	0.0029329	Syndecan-4	6385	SDC4	GO:0016477(BP:cell migration);GO:0006024(BP:glycosaminoglycan biosynthetic process);GO:0006027(BP:glycosaminoglycan catabolic process);GO:0060122(BP:inner ear receptor cell stereocilium organization);GO:0050900(BP:leukocyte migration);GO:0042130(BP:negative regulation of T cell proliferation);GO:0001843(BP:neural tube closure);GO:1903543(BP:positive regulation of exosomal secretion);GO:1903553(BP:positive regulation of extracellular exosome assembly);GO:0051894(BP:positive regulation of focal adhesion assembly);GO:0045860(BP:positive regulation of protein kinase activity);GO:0051496(BP:positive regulation of stress fiber assembly);GO:0010762(BP:regulation of fibroblast migration);GO:0001523(BP:retinoid metabolic process);GO:0001657(BP:ureteric bud development);GO:0042060(BP:wound healing);GO:0009986(CC:cell surface);GO:0043034(CC:costamere);GO:0070062(CC:extracellular exosome);GO:0005925(CC:focal adhesion);GO:0005796(CC:Golgi lumen);GO:0005887(CC:integral component of plasma membrane);GO:0043202(CC:lysosomal lumen);GO:0045121(CC:membrane raft);GO:0005886(CC:plasma membrane);GO:0001968(MF:fibronectin binding);GO:0042802(MF:identical protein binding);GO:0005080(MF:protein kinase C binding);GO:0070053(MF:thrombospondin receptor activity)	hsa04514(Cell adhesion molecules (CAMs));hsa04512(ECM-receptor interaction);hsa05205(Proteoglycans in cancer);hsa05418(Fluid shear stress and atherosclerosis)
Q9NUM4	1.33939	5.56E-05	Transmembrane protein 106B	54664	TMEM106B	GO:0048813(BP:dendrite morphogenesis);GO:0007041(BP:lysosomal transport);GO:0032418(BP:lysosome localization);GO:0007040(BP:lysosome organization);GO:1900006(BP:positive regulation of dendrite development);GO:0005768(CC:endosome);GO:0016021(CC:integral component of membrane);GO:0031902(CC:late endosome membrane);GO:0005765(CC:lysosomal membrane);GO:0005764(CC:lysosome)	-
Q9NX57	1.339148	0.033839743	Ras-related protein Rab-20	55647	RAB20	GO:0071346(BP:cellular response to interferon-gamma);GO:0006897(BP:endocytosis);GO:0006886(BP:intracellular protein transport);GO:0090383(BP:phagosome acidification);GO:0090385(BP:phagosome-lysosome fusion);GO:0032482(BP:Rab protein signal transduction);GO:0030100(BP:regulation of endocytosis);GO:0005769(CC:early endosome);GO:0030139(CC:endocytic vesicle);GO:0005768(CC:endosome);GO:0005794(CC:Golgi apparatus);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0045335(CC:phagocytic vesicle);GO:0030670(CC:phagocytic vesicle membrane);GO:0005886(CC:plasma membrane);GO:0005525(MF:GTP binding);GO:0003924(MF:GTPase activity)	-
Q14517	1.338449	0.000116842	Protocadherin Fat 1	2195	FAT1	GO:0007015(BP:actin filament organization);GO:0009653(BP:anatomical structure morphogenesis);GO:0048593(BP:camera-type eye morphogenesis);GO:0007155(BP:cell adhesion);GO:0016477(BP:cell migration);GO:0098609(BP:cell-cell adhesion);GO:0007267(BP:cell-cell signaling);GO:0003382(BP:epithelial cell morphogenesis);GO:0007163(BP:establishment or maintenance of cell polarity);GO:0045197(BP:establishment or maintenance of epithelial cell apical/basal polarity);GO:0007156(BP:homophilic cell adhesion via plasma membrane adhesion molecules);GO:0016324(CC:apical plasma membrane);GO:0005911(CC:cell-cell junction);GO:0070062(CC:extracellular exosome);GO:0030175(CC:filopodium);GO:0005925(CC:focal adhesion);GO:0005887(CC:integral component of plasma membrane);GO:0030027(CC:lamellipodium);GO:0005634(CC:nucleus);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0005509(MF:calcium ion binding)	-
Q8WV24	1.329188	0.038806295	Pleckstrin homology-like domain family A member 1	22822	PHLDA1	GO:0006915(BP:apoptotic process);GO:0045210(BP:FasL biosynthetic process);GO:0000086(BP:G2/M transition of mitotic cell cycle);GO:0031410(CC:cytoplasmic vesicle);GO:0005829(CC:cytosol);GO:0005730(CC:nucleolus);GO:0005634(CC:nucleus)	-
O95807	1.328597	0.015384919	Transmembrane protein 50A	23585	TMEM50A	GO:0032511(BP:late endosome to vacuole transport via multivesicular body sorting pathway);GO:0005783(CC:endoplasmic reticulum);GO:0097386(CC:glial cell projection);GO:0016021(CC:integral component of membrane);GO:0043025(CC:neuronal cell body)	-
Q13443	1.326531	0.003494531	Disintegrin and metalloproteinase domain-containing protein 9	8754	ADAM9	GO:0000186(BP:activation of MAPKK activity);GO:0007155(BP:cell adhesion);GO:0033627(BP:cell adhesion mediated by integrin);GO:0016477(BP:cell migration);GO:0033631(BP:cell-cell adhesion mediated by integrin);GO:0007160(BP:cell-matrix adhesion);GO:0071222(BP:cellular response to lipopolysaccharide);GO:0007229(BP:integrin-mediated signaling pathway);GO:0030216(BP:keratinocyte differentiation);GO:0006509(BP:membrane protein ectodomain proteolysis);GO:0042117(BP:monocyte activation);GO:0051088(BP:PMA-inducible membrane protein ectodomain proteolysis);GO:0033630(BP:positive regulation of cell adhesion mediated by integrin);GO:0051549(BP:positive regulation of keratinocyte migration);GO:0034241(BP:positive regulation of macrophage fusion);GO:0051044(BP:positive regulation of membrane protein ectodomain proteolysis);GO:0050714(BP:positive regulation of protein secretion);GO:0097327(BP:response to antineoplastic agent);GO:0051592(BP:response to calcium ion);GO:0051384(BP:response to glucocorticoid);GO:0042542(BP:response to hydrogen peroxide);GO:0034616(BP:response to laminar fluid shear stress);GO:0010042(BP:response to manganese ion);GO:0034612(BP:response to tumor necrosis factor);GO:0007179(BP:transforming growth factor beta receptor signaling pathway);GO:0016323(CC:basolateral plasma membrane);GO:0009986(CC:cell surface);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0005925(CC:focal adhesion);GO:0016021(CC:integral component of membrane);GO:0031233(CC:intrinsic component of external side of plasma membrane);GO:0005518(MF:collagen binding);GO:0005178(MF:integrin binding);GO:0043236(MF:laminin binding);GO:0046872(MF:metal ion binding);GO:0004222(MF:metalloendopeptidase activity);GO:0008237(MF:metallopeptidase activity);GO:0005080(MF:protein kinase C binding);GO:0017124(MF:SH3 domain binding)	-
Q8NC54	1.323546	0.028967042	Keratinocyte-associated transmembrane protein 2	56951	KCT2	GO:0016021(CC:integral component of membrane)	-
P09486	1.311075	0.001990246	SPARC	6678	SPARC	GO:0060348(BP:bone development);GO:0071363(BP:cellular response to growth factor stimulus);GO:0030198(BP:extracellular matrix organization);GO:0007507(BP:heart development);GO:0048839(BP:inner ear development);GO:0030324(BP:lung development);GO:0016525(BP:negative regulation of angiogenesis);GO:0001937(BP:negative regulation of endothelial cell proliferation);GO:0001503(BP:ossification);GO:0043473(BP:pigmentation);GO:0002576(BP:platelet degranulation);GO:0010595(BP:positive regulation of endothelial cell migration);GO:0006898(BP:receptor-mediated endocytosis);GO:0022604(BP:regulation of cell morphogenesis);GO:0050807(BP:regulation of synapse organization);GO:0046686(BP:response to cadmium ion);GO:0051592(BP:response to calcium ion);GO:0051591(BP:response to cAMP);GO:0034097(BP:response to cytokine);GO:0045471(BP:response to ethanol);GO:0051384(BP:response to glucocorticoid);GO:0009629(BP:response to gravity);GO:0033591(BP:response to L-ascorbic acid);GO:0010288(BP:response to lead ion);GO:0032496(BP:response to lipopolysaccharide);GO:0043434(BP:response to peptide hormone);GO:0042060(BP:wound healing);GO:0005604(CC:basement membrane);GO:0009986(CC:cell surface);GO:0005737(CC:cytoplasm);GO:0071682(CC:endocytic vesicle lumen);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0098978(CC:glutamatergic synapse);GO:0016363(CC:nuclear matrix);GO:0031091(CC:platelet alpha granule);GO:0031093(CC:platelet alpha granule lumen);GO:0031092(CC:platelet alpha granule membrane);GO:0005509(MF:calcium ion binding);GO:0005518(MF:collagen binding);GO:0050840(MF:extracellular matrix binding);GO:0005201(MF:extracellular matrix structural constituent)	-
P04920	1.308806	0.007789022	Anion exchange protein 2	6522	SLC4A2	GO:0006820(BP:anion transport);GO:0015701(BP:bicarbonate transport);GO:0048565(BP:digestive tract development);GO:0051453(BP:regulation of intracellular pH);GO:0007283(BP:spermatogenesis);GO:0016324(CC:apical plasma membrane);GO:0016323(CC:basolateral plasma membrane);GO:0005925(CC:focal adhesion);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0008509(MF:anion transmembrane transporter activity);GO:0015301(MF:anion:anion antiporter activity);GO:0019899(MF:enzyme binding);GO:0005452(MF:inorganic anion exchanger activity)	hsa04971(Gastric acid secretion);hsa04970(Salivary secretion);hsa04972(Pancreatic secretion);hsa04976(Bile secretion)
P23458	1.3083	0.000496243	Tyrosine-protein kinase JAK1	3716	JAK1	GO:0019221(BP:cytokine-mediated signaling pathway);GO:0060333(BP:interferon-gamma-mediated signaling pathway);GO:0035722(BP:interleukin-12-mediated signaling pathway);GO:0035723(BP:interleukin-15-mediated signaling pathway);GO:0038110(BP:interleukin-2-mediated signaling pathway);GO:0038114(BP:interleukin-21-mediated signaling pathway);GO:0070106(BP:interleukin-27-mediated signaling pathway);GO:0070757(BP:interleukin-35-mediated signaling pathway);GO:0070102(BP:interleukin-6-mediated signaling pathway);GO:0038111(BP:interleukin-7-mediated signaling pathway);GO:0038113(BP:interleukin-9-mediated signaling pathway);GO:0035556(BP:intracellular signal transduction);GO:0000165(BP:MAPK cascade);GO:1903672(BP:positive regulation of sprouting angiogenesis);GO:0006468(BP:protein phosphorylation);GO:0060334(BP:regulation of interferon-gamma-mediated signaling pathway);GO:0046677(BP:response to antibiotic);GO:0060337(BP:type I interferon signaling pathway);GO:0005737(CC:cytoplasm);GO:0005856(CC:cytoskeleton);GO:0005829(CC:cytosol);GO:0005768(CC:endosome);GO:0005925(CC:focal adhesion);GO:0016020(CC:membrane);GO:0005634(CC:nucleus);GO:0005524(MF:ATP binding);GO:0031730(MF:CCR5 chemokine receptor binding);GO:0005131(MF:growth hormone receptor binding);GO:0046872(MF:metal ion binding);GO:0004715(MF:non-membrane spanning protein tyrosine kinase activity);GO:0019903(MF:protein phosphatase binding);GO:0004713(MF:protein tyrosine kinase activity);GO:0031625(MF:ubiquitin protein ligase binding)	hsa05162(Measles);hsa05169(Epstein-Barr virus infection);hsa05200(Pathways in cancer);hsa04621(NOD-like receptor signaling pathway);hsa05163(Human cytomegalovirus infection);hsa04659(Th17 cell differentiation);hsa05152(Tuberculosis);hsa04151(PI3K-Akt signaling pathway);hsa04658(Th1 and Th2 cell differentiation);hsa05165(Human papillomavirus infection);hsa05145(Toxoplasmosis);hsa04217(Necroptosis);hsa05167(Kaposi sarcoma-associated herpesvirus infection);hsa05212(Pancreatic cancer);hsa04630(Jak-STAT signaling pathway);hsa05164(Influenza A);hsa04380(Osteoclast differentiation);hsa05166(Human T-cell leukemia virus 1 infection);hsa05168(Herpes simplex infection);hsa05140(Leishmaniasis);hsa05160(Hepatitis C);hsa01521(EGFR tyrosine kinase inhibitor resistance);hsa05161(Hepatitis B);hsa05203(Viral carcinogenesis);hsa04550(Signaling pathways regulating pluripotency of stem cells)
Q9NP84	1.30407	0.019705738	Tumor necrosis factor receptor superfamily member 12A	51330	TNFRSF12A	"GO:0001525(BP:angiogenesis);GO:0097191(BP:extrinsic apoptotic signaling pathway);GO:0043065(BP:positive regulation of apoptotic process);GO:0045773(BP:positive regulation of axon extension);GO:2001238(BP:positive regulation of extrinsic apoptotic signaling pathway);GO:0045765(BP:regulation of angiogenesis);GO:0061041(BP:regulation of wound healing);GO:0006931(BP:substrate-dependent cell migration, cell attachment to substrate);GO:0033209(BP:tumor necrosis factor-mediated signaling pathway);GO:0009986(CC:cell surface);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane);GO:0001726(CC:ruffle)"	hsa04060(Cytokine-cytokine receptor interaction)
P02656	1.300113	0.010581178	Apolipoprotein C-III	345	APOC3	GO:0033344(BP:cholesterol efflux);GO:0042632(BP:cholesterol homeostasis);GO:0034378(BP:chylomicron assembly);GO:0034382(BP:chylomicron remnant clearance);GO:0034371(BP:chylomicron remodeling);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0034375(BP:high-density lipoprotein particle remodeling);GO:0042157(BP:lipoprotein metabolic process);GO:0060621(BP:negative regulation of cholesterol import);GO:0045717(BP:negative regulation of fatty acid biosynthetic process);GO:0010987(BP:negative regulation of high-density lipoprotein particle clearance);GO:0050995(BP:negative regulation of lipid catabolic process);GO:0045833(BP:negative regulation of lipid metabolic process);GO:0051005(BP:negative regulation of lipoprotein lipase activity);GO:0010989(BP:negative regulation of low-density lipoprotein particle clearance);GO:0048261(BP:negative regulation of receptor-mediated endocytosis);GO:0010897(BP:negative regulation of triglyceride catabolic process);GO:0010916(BP:negative regulation of very-low-density lipoprotein particle clearance);GO:0010903(BP:negative regulation of very-low-density lipoprotein particle remodeling);GO:0033700(BP:phospholipid efflux);GO:0032489(BP:regulation of Cdc42 protein signal transduction);GO:0001523(BP:retinoid metabolic process);GO:0043691(BP:reverse cholesterol transport);GO:0019433(BP:triglyceride catabolic process);GO:0070328(BP:triglyceride homeostasis);GO:0006641(BP:triglyceride metabolic process);GO:0034379(BP:very-low-density lipoprotein particle assembly);GO:0042627(CC:chylomicron);GO:0005769(CC:early endosome);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0034363(CC:intermediate-density lipoprotein particle);GO:0034366(CC:spherical high-density lipoprotein particle);GO:0034361(CC:very-low-density lipoprotein particle);GO:0015485(MF:cholesterol binding);GO:0030234(MF:enzyme regulator activity);GO:0070653(MF:high-density lipoprotein particle receptor binding);GO:0055102(MF:lipase inhibitor activity);GO:0005543(MF:phospholipid binding)	hsa03320(PPAR signaling pathway);hsa04979(Cholesterol metabolism)
P60033	1.299096	0.001469616	CD81 antigen	975	CD81	"GO:0000187(BP:activation of MAPK activity);GO:0035783(BP:CD4-positive, alpha-beta T cell costimulation);GO:0007166(BP:cell surface receptor signaling pathway);GO:0071404(BP:cellular response to low-density lipoprotein particle stimulus);GO:0002455(BP:humoral immune response mediated by circulating immunoglobulin);GO:0001771(BP:immunological synapse formation);GO:0034238(BP:macrophage fusion);GO:0014905(BP:myoblast fusion involved in skeletal muscle regeneration);GO:0072675(BP:osteoclast fusion);GO:0043128(BP:positive regulation of 1-phosphatidylinositol 4-kinase activity);GO:1905676(BP:positive regulation of adaptive immune memory response);GO:0030890(BP:positive regulation of B cell proliferation);GO:0050861(BP:positive regulation of B cell receptor signaling pathway);GO:2000563(BP:positive regulation of CD4-positive, alpha-beta T cell proliferation);GO:0008284(BP:positive regulation of cell proliferation);GO:0002863(BP:positive regulation of inflammatory response to antigenic stimulus);GO:0050731(BP:positive regulation of peptidyl-tyrosine phosphorylation);GO:1904352(BP:positive regulation of protein catabolic process in the vacuole);GO:0070863(BP:positive regulation of protein exit from endoplasmic reticulum);GO:1903911(BP:positive regulation of receptor clustering);GO:2001190(BP:positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell);GO:0050862(BP:positive regulation of T cell receptor signaling pathway);GO:2000553(BP:positive regulation of T-helper 2 cell cytokine production);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0008104(BP:protein localization);GO:0061462(BP:protein localization to lysosome);GO:0072659(BP:protein localization to plasma membrane);GO:0031623(BP:receptor internalization);GO:0046813(BP:receptor-mediated virion attachment to host cell);GO:0030449(BP:regulation of complement activation);GO:0050776(BP:regulation of immune response);GO:1905521(BP:regulation of macrophage migration);GO:0031647(BP:regulation of protein stability);GO:0046718(BP:viral entry into host cell);GO:0016323(CC:basolateral plasma membrane);GO:0070062(CC:extracellular exosome);GO:0005925(CC:focal adhesion);GO:0001772(CC:immunological synapse);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0097197(CC:tetraspanin-enriched microdomain);GO:0031982(CC:vesicle);GO:0015485(MF:cholesterol binding);GO:0005178(MF:integrin binding);GO:0042289(MF:MHC class II protein binding);GO:0023026(MF:MHC class II protein complex binding);GO:1990459(MF:transferrin receptor binding);GO:0001618(MF:virus receptor activity)"	hsa05160(Hepatitis C);hsa04662(B cell receptor signaling pathway);hsa05144(Malaria)
P48449	1.298327	0.002692845	Lanosterol synthase	4047	LSS	GO:0006695(BP:cholesterol biosynthetic process);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0031647(BP:regulation of protein stability);GO:0006694(BP:steroid biosynthetic process);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005811(CC:lipid droplet);GO:0016020(CC:membrane);GO:0000250(MF:lanosterol synthase activity)	hsa00100(Steroid biosynthesis)
Q8N697	1.297199	0.017917554	Solute carrier family 15 member 4	121260	SLC15A4	GO:0015817(BP:histidine transport);GO:0006811(BP:ion transport);GO:0043312(BP:neutrophil degranulation);GO:0015031(BP:protein transport);GO:0016021(CC:integral component of membrane);GO:0005765(CC:lysosomal membrane);GO:0005886(CC:plasma membrane);GO:0035579(CC:specific granule membrane);GO:0005290(MF:L-histidine transmembrane transporter activity);GO:0035673(MF:oligopeptide transmembrane transporter activity);GO:1904680(MF:peptide transmembrane transporter activity);GO:0015333(MF:peptide:proton symporter activity)	-
Q92504	1.296367	0.036414331	Zinc transporter SLC39A7	7922	SLC39A7	GO:0006882(BP:cellular zinc ion homeostasis);GO:0071577(BP:zinc ion transmembrane transport);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005794(CC:Golgi apparatus);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005654(CC:nucleoplasm);GO:0005385(MF:zinc ion transmembrane transporter activity)	-
Q86WC4	1.294422	0.000563795	Osteopetrosis-associated transmembrane protein 1	28962	OSTM1	GO:0034220(BP:ion transmembrane transport);GO:0030316(BP:osteoclast differentiation);GO:0005829(CC:cytosol);GO:0016021(CC:integral component of membrane);GO:0005765(CC:lysosomal membrane)	-
Q7Z3E5	1.293703	0.02095612	LisH domain-containing protein ARMC9	80210	ARMC9	GO:0060271(BP:cilium assembly);GO:0036064(CC:ciliary basal body);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome)	-
P04156	1.291692	0.011821756	Major prion protein	5621	PRNP	GO:0032147(BP:activation of protein kinase activity);GO:0035584(BP:calcium-mediated signaling using intracellular calcium source);GO:0007050(BP:cell cycle arrest);GO:0006878(BP:cellular copper ion homeostasis);GO:1904646(BP:cellular response to amyloid-beta);GO:0071280(BP:cellular response to copper ion);GO:0035690(BP:cellular response to drug);GO:0097062(BP:dendritic spine maintenance);GO:0007611(BP:learning or memory);GO:0007616(BP:long-term memory);GO:0090647(BP:modulation of age-related behavioral decline);GO:0046007(BP:negative regulation of activated T cell proliferation);GO:1902992(BP:negative regulation of amyloid precursor protein catabolic process);GO:1902430(BP:negative regulation of amyloid-beta formation);GO:0043066(BP:negative regulation of apoptotic process);GO:0070885(BP:negative regulation of calcineurin-NFAT signaling cascade);GO:0043086(BP:negative regulation of catalytic activity);GO:1902951(BP:negative regulation of dendritic spine maintenance);GO:0043433(BP:negative regulation of DNA binding transcription factor activity);GO:0032689(BP:negative regulation of interferon-gamma production);GO:0032700(BP:negative regulation of interleukin-17 production);GO:0032703(BP:negative regulation of interleukin-2 production);GO:1900272(BP:negative regulation of long-term synaptic potentiation);GO:0001933(BP:negative regulation of protein phosphorylation);GO:0010955(BP:negative regulation of protein processing);GO:0050860(BP:negative regulation of T cell receptor signaling pathway);GO:1990535(BP:neuron projection maintenance);GO:0043525(BP:positive regulation of neuron apoptotic process);GO:1901216(BP:positive regulation of neuron death);GO:0050731(BP:positive regulation of peptidyl-tyrosine phosphorylation);GO:1903078(BP:positive regulation of protein localization to plasma membrane);GO:0090314(BP:positive regulation of protein targeting to membrane);GO:0061098(BP:positive regulation of protein tyrosine kinase activity);GO:0031648(BP:protein destabilization);GO:0051260(BP:protein homooligomerization);GO:1905664(BP:regulation of calcium ion import across plasma membrane);GO:1900449(BP:regulation of glutamate receptor signaling pathway);GO:1902938(BP:regulation of intracellular calcium activated chloride channel activity);GO:0050730(BP:regulation of peptidyl-tyrosine phosphorylation);GO:1901379(BP:regulation of potassium ion transmembrane transport);GO:1904645(BP:response to amyloid-beta);GO:0046686(BP:response to cadmium ion);GO:0006979(BP:response to oxidative stress);GO:0031362(CC:anchored component of external side of plasma membrane);GO:0009986(CC:cell surface);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0030425(CC:dendrite);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0019898(CC:extrinsic component of membrane);GO:0005794(CC:Golgi apparatus);GO:0016234(CC:inclusion body);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0045121(CC:membrane raft);GO:0031965(CC:nuclear membrane);GO:0005886(CC:plasma membrane);GO:0098794(CC:postsynapse);GO:0014069(CC:postsynaptic density);GO:0001540(MF:amyloid-beta binding);GO:0043008(MF:ATP-dependent protein binding);GO:0051087(MF:chaperone binding);GO:0005507(MF:copper ion binding);GO:1903135(MF:cupric ion binding);GO:1903136(MF:cuprous ion binding);GO:0005539(MF:glycosaminoglycan binding);GO:0042802(MF:identical protein binding);GO:0044325(MF:ion channel binding);GO:0005521(MF:lamin binding);GO:0008017(MF:microtubule binding);GO:0002020(MF:protease binding);GO:0044877(MF:protein-containing complex binding);GO:0038023(MF:signaling receptor activity);GO:0015631(MF:tubulin binding);GO:0031802(MF:type 5 metabotropic glutamate receptor binding)	hsa04216(Ferroptosis);hsa05020(Prion diseases)
P07996	1.287274	0.002343306	Thrombospondin-1	7057	THBS1	GO:0000187(BP:activation of MAPK activity);GO:0048266(BP:behavioral response to pain);GO:0007155(BP:cell adhesion);GO:0007050(BP:cell cycle arrest);GO:0016477(BP:cell migration);GO:0071363(BP:cellular response to growth factor stimulus);GO:0034605(BP:cellular response to heat);GO:0071356(BP:cellular response to tumor necrosis factor);GO:0002544(BP:chronic inflammatory response);GO:0043652(BP:engulfment of apoptotic cell);GO:0030198(BP:extracellular matrix organization);GO:0006955(BP:immune response);GO:0006954(BP:inflammatory response);GO:0016525(BP:negative regulation of angiogenesis);GO:0002581(BP:negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II);GO:0043066(BP:negative regulation of apoptotic process);GO:0043537(BP:negative regulation of blood vessel endothelial cell migration);GO:1903588(BP:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis);GO:0090051(BP:negative regulation of cell migration involved in sprouting angiogenesis);GO:0001953(BP:negative regulation of cell-matrix adhesion);GO:0010754(BP:negative regulation of cGMP-mediated signaling);GO:0043154(BP:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0002605(BP:negative regulation of dendritic cell antigen processing and presentation);GO:2001027(BP:negative regulation of endothelial cell chemotaxis);GO:0010596(BP:negative regulation of endothelial cell migration);GO:0001937(BP:negative regulation of endothelial cell proliferation);GO:2001237(BP:negative regulation of extrinsic apoptotic signaling pathway);GO:0051918(BP:negative regulation of fibrinolysis);GO:0040037(BP:negative regulation of fibroblast growth factor receptor signaling pathway);GO:0051895(BP:negative regulation of focal adhesion assembly);GO:0032695(BP:negative regulation of interleukin-12 production);GO:0010748(BP:negative regulation of plasma membrane long-chain fatty acid transport);GO:0010751(BP:negative regulation of nitric oxide mediated signal transduction);GO:0010757(BP:negative regulation of plasminogen activation);GO:1903671(BP:negative regulation of sprouting angiogenesis);GO:0018149(BP:peptide cross-linking);GO:0002576(BP:platelet degranulation);GO:0045766(BP:positive regulation of angiogenesis);GO:0030194(BP:positive regulation of blood coagulation);GO:0043536(BP:positive regulation of blood vessel endothelial cell migration);GO:0030335(BP:positive regulation of cell migration);GO:0008284(BP:positive regulation of cell proliferation);GO:0050921(BP:positive regulation of chemotaxis);GO:2000353(BP:positive regulation of endothelial cell apoptotic process);GO:0010595(BP:positive regulation of endothelial cell migration);GO:1902043(BP:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors);GO:0010763(BP:positive regulation of fibroblast migration);GO:0043032(BP:positive regulation of macrophage activation);GO:0010759(BP:positive regulation of macrophage chemotaxis);GO:0042327(BP:positive regulation of phosphorylation);GO:0051897(BP:positive regulation of protein kinase B signaling);GO:2000379(BP:positive regulation of reactive oxygen species metabolic process);GO:0048661(BP:positive regulation of smooth muscle cell proliferation);GO:0030511(BP:positive regulation of transforming growth factor beta receptor signaling pathway);GO:0032914(BP:positive regulation of transforming growth factor beta1 production);GO:0045727(BP:positive regulation of translation);GO:0042535(BP:positive regulation of tumor necrosis factor biosynthetic process);GO:0045652(BP:regulation of megakaryocyte differentiation);GO:0051592(BP:response to calcium ion);GO:0042493(BP:response to drug);GO:0034976(BP:response to endoplasmic reticulum stress);GO:0009749(BP:response to glucose);GO:0001666(BP:response to hypoxia);GO:0032026(BP:response to magnesium ion);GO:0009612(BP:response to mechanical stimulus);GO:0032570(BP:response to progesterone);GO:0033574(BP:response to testosterone);GO:0006986(BP:response to unfolded protein);GO:0002040(BP:sprouting angiogenesis);GO:0009986(CC:cell surface);GO:0005783(CC:endoplasmic reticulum);GO:0005788(CC:endoplasmic reticulum lumen);GO:0009897(CC:external side of plasma membrane);GO:0070062(CC:extracellular exosome);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005577(CC:fibrinogen complex);GO:0031091(CC:platelet alpha granule);GO:0031093(CC:platelet alpha granule lumen);GO:0016529(CC:sarcoplasmic reticulum);GO:0030141(CC:secretory granule);GO:0005509(MF:calcium ion binding);GO:0070052(MF:collagen V binding);GO:0005201(MF:extracellular matrix structural constituent);GO:0070051(MF:fibrinogen binding);GO:0017134(MF:fibroblast growth factor binding);GO:0001968(MF:fibronectin binding);GO:0008201(MF:heparin binding);GO:0042802(MF:identical protein binding);GO:0005178(MF:integrin binding);GO:0043236(MF:laminin binding);GO:0030169(MF:low-density lipoprotein particle binding);GO:0001786(MF:phosphatidylserine binding);GO:0043394(MF:proteoglycan binding);GO:0050431(MF:transforming growth factor beta binding)	hsa05165(Human papillomavirus infection);hsa05205(Proteoglycans in cancer);hsa04350(TGF-beta signaling pathway);hsa04145(Phagosome);hsa04015(Rap1 signaling pathway);hsa04510(Focal adhesion);hsa04115(p53 signaling pathway);hsa04512(ECM-receptor interaction);hsa05206(MicroRNAs in cancer);hsa05144(Malaria);hsa05219(Bladder cancer);hsa04151(PI3K-Akt signaling pathway)
O43299	1.284962	0.037163661	AP-5 complex subunit zeta-1	9907	AP5Z1	GO:0000724(BP:double-strand break repair via homologous recombination);GO:0016197(BP:endosomal transport);GO:0015031(BP:protein transport);GO:0044599(CC:AP-5 adaptor complex);GO:0030119(CC:AP-type membrane coat adaptor complex);GO:0005737(CC:cytoplasm);GO:0016607(CC:nuclear speck);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus)	-
Q9UBP4	1.284385	0.030917484	Dickkopf-related protein 3	27122	DKK3	"GO:0030325(BP:adrenal gland development);GO:0009653(BP:anatomical structure morphogenesis);GO:0032348(BP:negative regulation of aldosterone biosynthetic process);GO:1902613(BP:negative regulation of anti-Mullerian hormone signaling pathway);GO:0090090(BP:negative regulation of canonical Wnt signaling pathway);GO:2000065(BP:negative regulation of cortisol biosynthetic process);GO:0045892(BP:negative regulation of transcription, DNA-templated);GO:0017015(BP:regulation of transforming growth factor beta receptor signaling pathway);GO:0016055(BP:Wnt signaling pathway);GO:0005615(CC:extracellular space);GO:0039706(MF:co-receptor binding);GO:0048019(MF:receptor antagonist activity)"	-
Q13907	1.281707	2.15E-05	Isopentenyl-diphosphate Delta-isomerase 1	3422	IDI1	GO:0006695(BP:cholesterol biosynthetic process);GO:0050992(BP:dimethylallyl diphosphate biosynthetic process);GO:0009240(BP:isopentenyl diphosphate biosynthetic process);GO:0008299(BP:isoprenoid biosynthetic process);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0005829(CC:cytosol);GO:0005777(CC:peroxisome);GO:0016787(MF:hydrolase activity);GO:0004452(MF:isopentenyl-diphosphate delta-isomerase activity);GO:0000287(MF:magnesium ion binding);GO:0030145(MF:manganese ion binding);GO:0046872(MF:metal ion binding)	hsa00900(Terpenoid backbone biosynthesis)
Q04721	1.281658	0.03245158	Neurogenic locus notch homolog protein 2	4853	NOTCH2	"GO:0009887(BP:animal organ morphogenesis);GO:0006915(BP:apoptotic process);GO:0060413(BP:atrial septum morphogenesis);GO:0046849(BP:bone remodeling);GO:0007050(BP:cell cycle arrest);GO:0001709(BP:cell fate determination);GO:0030097(BP:hemopoiesis);GO:0002315(BP:marginal zone B cell differentiation);GO:0007275(BP:multicellular organism development);GO:0043066(BP:negative regulation of apoptotic process);GO:0010629(BP:negative regulation of gene expression);GO:0045967(BP:negative regulation of growth rate);GO:0007399(BP:nervous system development);GO:0061314(BP:Notch signaling involved in heart development);GO:0007219(BP:Notch signaling pathway);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:0046579(BP:positive regulation of Ras protein signal transduction);GO:0003184(BP:pulmonary valve morphogenesis);GO:2001204(BP:regulation of osteoclast development);GO:0006355(BP:regulation of transcription, DNA-templated);GO:0019827(BP:stem cell population maintenance);GO:0006367(BP:transcription initiation from RNA polymerase II promoter);GO:0009986(CC:cell surface);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005576(CC:extracellular region);GO:0000139(CC:Golgi membrane);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0043235(CC:receptor complex);GO:0005509(MF:calcium ion binding);GO:0038023(MF:signaling receptor activity)"	hsa05206(MicroRNAs in cancer);hsa05200(Pathways in cancer);hsa04919(Thyroid hormone signaling pathway);hsa01522(Endocrine resistance);hsa04330(Notch signaling pathway);hsa05165(Human papillomavirus infection);hsa04658(Th1 and Th2 cell differentiation);hsa05224(Breast cancer)
P58397	1.279205	0.007226271	A disintegrin and metalloproteinase with thrombospondin motifs 12	81792	ADAMTS12	GO:0016477(BP:cell migration);GO:0007160(BP:cell-matrix adhesion);GO:0071773(BP:cellular response to BMP stimulus);GO:0071347(BP:cellular response to interleukin-1);GO:0071356(BP:cellular response to tumor necrosis factor);GO:2001113(BP:negative regulation of cellular response to hepatocyte growth factor stimulus);GO:1902548(BP:negative regulation of cellular response to vascular endothelial growth factor stimulus);GO:0032331(BP:negative regulation of chondrocyte differentiation);GO:1902203(BP:negative regulation of hepatocyte growth factor receptor signaling pathway);GO:0030167(BP:proteoglycan catabolic process);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:1901509(BP:regulation of endothelial tube morphogenesis);GO:0050727(BP:regulation of inflammatory response);GO:0046872(MF:metal ion binding);GO:0004222(MF:metalloendopeptidase activity)	-
Q96AQ6	1.278091	0.001405477	Pre-B-cell leukemia transcription factor-interacting protein 1	57326	PBXIP1	"GO:0030154(BP:cell differentiation);GO:0007275(BP:multicellular organism development);GO:0045892(BP:negative regulation of transcription, DNA-templated);GO:0005829(CC:cytosol);GO:0005874(CC:microtubule);GO:0005634(CC:nucleus);GO:0003714(MF:transcription corepressor activity)"	-
Q15274	1.277957	0.000188113	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	23475	QPRT	GO:0009435(BP:NAD biosynthetic process);GO:0019674(BP:NAD metabolic process);GO:0051259(BP:protein complex oligomerization);GO:0034213(BP:quinolinate catabolic process);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0004514(MF:nicotinate-nucleotide diphosphorylase (carboxylating) activity);GO:0042803(MF:protein homodimerization activity)	hsa00760(Nicotinate and nicotinamide metabolism)
O14493	1.27686	0.001602695	Claudin-4	1364	CLDN4	GO:0016338(BP:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules);GO:0007623(BP:circadian rhythm);GO:0061436(BP:establishment of skin barrier);GO:0007565(BP:female pregnancy);GO:0070293(BP:renal absorption);GO:0032570(BP:response to progesterone);GO:0016324(CC:apical plasma membrane);GO:0016327(CC:apicolateral plasma membrane);GO:0009925(CC:basal plasma membrane);GO:0005923(CC:bicellular tight junction);GO:0034707(CC:chloride channel complex);GO:0005887(CC:integral component of plasma membrane);GO:0016328(CC:lateral plasma membrane);GO:0005886(CC:plasma membrane);GO:0005254(MF:chloride channel activity);GO:0042802(MF:identical protein binding);GO:0005198(MF:structural molecule activity);GO:0004888(MF:transmembrane signaling receptor activity)	hsa04514(Cell adhesion molecules (CAMs));hsa04670(Leukocyte transendothelial migration);hsa05160(Hepatitis C);hsa04530(Tight junction)
P30530	1.274234	0.00424406	Tyrosine-protein kinase receptor UFO	558	AXL	GO:0031100(BP:animal organ regeneration);GO:0043277(BP:apoptotic cell clearance);GO:0001974(BP:blood vessel remodeling);GO:0048469(BP:cell maturation);GO:0016477(BP:cell migration);GO:0031668(BP:cellular response to extracellular stimulus);GO:0070301(BP:cellular response to hydrogen peroxide);GO:0035457(BP:cellular response to interferon-alpha);GO:0071222(BP:cellular response to lipopolysaccharide);GO:0097028(BP:dendritic cell differentiation);GO:0034101(BP:erythrocyte homeostasis);GO:0021885(BP:forebrain cell migration);GO:0006954(BP:inflammatory response);GO:0045087(BP:innate immune response);GO:0001779(BP:natural killer cell differentiation);GO:0043066(BP:negative regulation of apoptotic process);GO:2000669(BP:negative regulation of dendritic cell apoptotic process);GO:0032689(BP:negative regulation of interferon-gamma production);GO:0051250(BP:negative regulation of lymphocyte activation);GO:0043524(BP:negative regulation of neuron apoptotic process);GO:0032720(BP:negative regulation of tumor necrosis factor production);GO:0007399(BP:nervous system development);GO:0001764(BP:neuron migration);GO:0097350(BP:neutrophil clearance);GO:0042698(BP:ovulation cycle);GO:0006909(BP:phagocytosis);GO:0030168(BP:platelet activation);GO:0001961(BP:positive regulation of cytokine-mediated signaling pathway);GO:0032825(BP:positive regulation of natural killer cell differentiation);GO:0048549(BP:positive regulation of pinocytosis);GO:0051897(BP:positive regulation of protein kinase B signaling);GO:0043491(BP:protein kinase B signaling);GO:0032940(BP:secretion by cell);GO:0007165(BP:signal transduction);GO:0007283(BP:spermatogenesis);GO:0034446(BP:substrate adhesion-dependent cell spreading);GO:0007169(BP:transmembrane receptor protein tyrosine kinase signaling pathway);GO:0060068(BP:vagina development);GO:0048010(BP:vascular endothelial growth factor receptor signaling pathway);GO:0046718(BP:viral entry into host cell);GO:0016055(BP:Wnt signaling pathway);GO:0009986(CC:cell surface);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0044228(CC:host cell surface);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0043235(CC:receptor complex);GO:0005524(MF:ATP binding);GO:0032036(MF:myosin heavy chain binding);GO:0043548(MF:phosphatidylinositol 3-kinase binding);GO:0001786(MF:phosphatidylserine binding);GO:0046982(MF:protein heterodimerization activity);GO:0004713(MF:protein tyrosine kinase activity);GO:0004714(MF:transmembrane receptor protein tyrosine kinase activity);GO:0001618(MF:virus receptor activity);GO:0017147(MF:Wnt-protein binding)	hsa01521(EGFR tyrosine kinase inhibitor resistance)
P26022	1.272209	0.000979944	Pentraxin-related protein PTX3	5806	PTX3	GO:0030198(BP:extracellular matrix organization);GO:0006954(BP:inflammatory response);GO:0045087(BP:innate immune response);GO:0044869(BP:negative regulation by host of viral exo-alpha-sialidase activity);GO:0044871(BP:negative regulation by host of viral glycoprotein metabolic process);GO:1903016(BP:negative regulation of exo-alpha-sialidase activity);GO:1903019(BP:negative regulation of glycoprotein metabolic process);GO:0046597(BP:negative regulation of viral entry into host cell);GO:0043312(BP:neutrophil degranulation);GO:0008228(BP:opsonization);GO:0001550(BP:ovarian cumulus expansion);GO:0045429(BP:positive regulation of nitric oxide biosynthetic process);GO:0050766(BP:positive regulation of phagocytosis);GO:0001878(BP:response to yeast);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0035580(CC:specific granule lumen);GO:1904724(CC:tertiary granule lumen);GO:0001872(MF:(1->3)-beta-D-glucan binding);GO:0001849(MF:complement component C1q binding);GO:0042802(MF:identical protein binding);GO:0046790(MF:virion binding)	-
P08195	1.271663	0.00027935	4F2 cell-surface antigen heavy chain	6520	SLC3A2	GO:0006865(BP:amino acid transport);GO:0006816(BP:calcium ion transport);GO:0005975(BP:carbohydrate metabolic process);GO:1902475(BP:L-alpha-amino acid transmembrane transport);GO:1903801(BP:L-leucine import across plasma membrane);GO:0050900(BP:leukocyte migration);GO:0043330(BP:response to exogenous dsRNA);GO:0015827(BP:tryptophan transport);GO:0016324(CC:apical plasma membrane);GO:0009986(CC:cell surface);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0016021(CC:integral component of membrane);GO:0042470(CC:melanosome);GO:0016020(CC:membrane);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0045296(MF:cadherin binding);GO:0005432(MF:calcium:sodium antiporter activity);GO:0003824(MF:catalytic activity);GO:0003725(MF:double-stranded RNA binding);GO:0015175(MF:neutral amino acid transmembrane transporter activity);GO:0003723(MF:RNA binding)	hsa04216(Ferroptosis);hsa04150(mTOR signaling pathway);hsa04974(Protein digestion and absorption)
Q9C0K1	1.269682	0.006157766	Zinc transporter ZIP8	64116	SLC39A8	GO:0070574(BP:cadmium ion transmembrane transport);GO:0006882(BP:cellular zinc ion homeostasis);GO:0071578(BP:zinc ion import across plasma membrane);GO:0006829(BP:zinc ion transport);GO:0005887(CC:integral component of plasma membrane);GO:0031090(CC:organelle membrane);GO:0005886(CC:plasma membrane);GO:0005385(MF:zinc ion transmembrane transporter activity)	hsa04216(Ferroptosis)
P09601	1.268365	0.016464954	Heme oxygenase 1	3162	HMOX1	GO:0001525(BP:angiogenesis);GO:0008219(BP:cell death);GO:0006879(BP:cellular iron ion homeostasis);GO:0071243(BP:cellular response to arsenic-containing substance);GO:0071276(BP:cellular response to cadmium ion);GO:0072719(BP:cellular response to cisplatin);GO:0034605(BP:cellular response to heat);GO:0071456(BP:cellular response to hypoxia);GO:0031670(BP:cellular response to nutrient);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0001935(BP:endothelial cell proliferation);GO:0034101(BP:erythrocyte homeostasis);GO:0007588(BP:excretion);GO:0042167(BP:heme catabolic process);GO:0006788(BP:heme oxidation);GO:0035556(BP:intracellular signal transduction);GO:0008630(BP:intrinsic apoptotic signaling pathway in response to DNA damage);GO:0055072(BP:iron ion homeostasis);GO:0097421(BP:liver regeneration);GO:0034383(BP:low-density lipoprotein particle clearance);GO:0043392(BP:negative regulation of DNA binding);GO:0043433(BP:negative regulation of DNA binding transcription factor activity);GO:1904036(BP:negative regulation of epithelial cell apoptotic process);GO:1902042(BP:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors);GO:0002686(BP:negative regulation of leukocyte migration);GO:0016242(BP:negative regulation of macroautophagy);GO:0032764(BP:negative regulation of mast cell cytokine production);GO:0043305(BP:negative regulation of mast cell degranulation);GO:0010656(BP:negative regulation of muscle cell apoptotic process);GO:0043524(BP:negative regulation of neuron apoptotic process);GO:0048662(BP:negative regulation of smooth muscle cell proliferation);GO:1904706(BP:negative regulation of vascular smooth muscle cell proliferation);GO:0045766(BP:positive regulation of angiogenesis);GO:0043065(BP:positive regulation of apoptotic process);GO:0097755(BP:positive regulation of blood vessel diameter);GO:1903589(BP:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis);GO:0090050(BP:positive regulation of cell migration involved in sprouting angiogenesis);GO:0045080(BP:positive regulation of chemokine biosynthetic process);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0016239(BP:positive regulation of macroautophagy);GO:0048661(BP:positive regulation of smooth muscle cell proliferation);GO:0051260(BP:protein homooligomerization);GO:0045765(BP:regulation of angiogenesis);GO:0008217(BP:regulation of blood pressure);GO:0051090(BP:regulation of DNA binding transcription factor activity);GO:0034395(BP:regulation of transcription from RNA polymerase II promoter in response to iron);GO:0043619(BP:regulation of transcription from RNA polymerase II promoter in response to oxidative stress);GO:0043627(BP:response to estrogen);GO:0042542(BP:response to hydrogen peroxide);GO:0035094(BP:response to nicotine);GO:0006979(BP:response to oxidative stress);GO:0007264(BP:small GTPase mediated signal transduction);GO:0014806(BP:smooth muscle hyperplasia);GO:0002246(BP:wound healing involved in inflammatory response);GO:0005901(CC:caveola);GO:0005829(CC:cytosol);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005615(CC:extracellular space);GO:0016020(CC:membrane);GO:0005730(CC:nucleolus);GO:0005634(CC:nucleus);GO:0048471(CC:perinuclear region of cytoplasm);GO:0019899(MF:enzyme binding);GO:0020037(MF:heme binding);GO:0004392(MF:heme oxygenase (decyclizing) activity);GO:0046872(MF:metal ion binding);GO:0004630(MF:phospholipase D activity);GO:0042803(MF:protein homodimerization activity)	hsa04066(HIF-1 signaling pathway);hsa05418(Fluid shear stress and atherosclerosis);hsa04216(Ferroptosis);hsa05225(Hepatocellular carcinoma);hsa05200(Pathways in cancer);hsa05206(MicroRNAs in cancer);hsa00860(Porphyrin and chlorophyll metabolism);hsa04978(Mineral absorption)
Q9NZ42	1.268291	0.011780649	Gamma-secretase subunit PEN-2	55851	PSENEN	"GO:0042987(BP:amyloid precursor protein catabolic process);GO:0042982(BP:amyloid precursor protein metabolic process);GO:0034205(BP:amyloid-beta formation);GO:0044267(BP:cellular protein metabolic process);GO:0048013(BP:ephrin receptor signaling pathway);GO:0006509(BP:membrane protein ectodomain proteolysis);GO:0031293(BP:membrane protein intracellular domain proteolysis);GO:0007220(BP:Notch receptor processing);GO:0035333(BP:Notch receptor processing, ligand-dependent);GO:0043065(BP:positive regulation of apoptotic process);GO:0043085(BP:positive regulation of catalytic activity);GO:0016485(BP:protein processing);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0010008(CC:endosome membrane);GO:0070765(CC:gamma-secretase complex);GO:0005794(CC:Golgi apparatus);GO:0032580(CC:Golgi cisterna membrane);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane)"	hsa04330(Notch signaling pathway);hsa05010(Alzheimer disease)
Q03426	1.263941	0.001264669	Mevalonate kinase	4598	MVK	"GO:0006695(BP:cholesterol biosynthetic process);GO:0019287(BP:isopentenyl diphosphate biosynthetic process, mevalonate pathway);GO:0008299(BP:isoprenoid biosynthetic process);GO:0050728(BP:negative regulation of inflammatory response);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0005829(CC:cytosol);GO:0005777(CC:peroxisome);GO:0005524(MF:ATP binding);GO:0042802(MF:identical protein binding);GO:0000287(MF:magnesium ion binding);GO:0004496(MF:mevalonate kinase activity)"	hsa00900(Terpenoid backbone biosynthesis);hsa04146(Peroxisome)
Q2TAZ0	1.263657	0.002420921	Autophagy-related protein 2 homolog A	23130	ATG2A	GO:0000045(BP:autophagosome assembly);GO:0000422(BP:autophagy of mitochondrion);GO:0005829(CC:cytosol);GO:0019898(CC:extrinsic component of membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005811(CC:lipid droplet);GO:0005634(CC:nucleus);GO:0000407(CC:phagophore assembly site);GO:0034045(CC:phagophore assembly site membrane)	hsa04136(Autophagy - other);hsa04140(Autophagy - animal)
Q9UL01	1.263631	0.002034089	Dermatan-sulfate epimerase	29940	DSE	GO:0030206(BP:chondroitin sulfate biosynthetic process);GO:0030208(BP:dermatan sulfate biosynthetic process);GO:0015012(BP:heparan sulfate proteoglycan biosynthetic process);GO:0005829(CC:cytosol);GO:0005783(CC:endoplasmic reticulum);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane);GO:0005654(CC:nucleoplasm);GO:0047757(MF:chondroitin-glucuronate 5-epimerase activity)	hsa00532(Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate)
P46926	1.263143	0.012477238	Glucosamine-6-phosphate isomerase 1	10007	GNPDA1	GO:0005975(BP:carbohydrate metabolic process);GO:0006091(BP:generation of precursor metabolites and energy);GO:0006043(BP:glucosamine catabolic process);GO:0006046(BP:N-acetylglucosamine catabolic process);GO:0019262(BP:N-acetylneuraminate catabolic process);GO:0007338(BP:single fertilization);GO:0006048(BP:UDP-N-acetylglucosamine biosynthetic process);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0004342(MF:glucosamine-6-phosphate deaminase activity);GO:0042802(MF:identical protein binding)	hsa00520(Amino sugar and nucleotide sugar metabolism)
Q658P3	1.261484	0.000901109	Metalloreductase STEAP3	55240	STEAP3	GO:0006915(BP:apoptotic process);GO:0007049(BP:cell cycle);GO:0015677(BP:copper ion import);GO:0055072(BP:iron ion homeostasis);GO:0098706(BP:ferric iron import across plasma membrane);GO:0055114(BP:oxidation-reduction process);GO:0009306(BP:protein secretion);GO:0042981(BP:regulation of apoptotic process);GO:0033572(BP:transferrin transport);GO:0005737(CC:cytoplasm);GO:0005768(CC:endosome);GO:0010008(CC:endosome membrane);GO:0016021(CC:integral component of membrane);GO:0005771(CC:multivesicular body);GO:0005886(CC:plasma membrane);GO:0008823(MF:cupric reductase activity);GO:0052851(MF:ferric-chelate reductase (NADPH) activity);GO:0042802(MF:identical protein binding);GO:0046872(MF:metal ion binding)	hsa04115(p53 signaling pathway);hsa04216(Ferroptosis)
Q96D42	1.256873	0.001236194	Hepatitis A virus cellular receptor 1	26762	HAVCR1	GO:0016021(CC:integral component of membrane);GO:0031514(CC:motile cilium);GO:0001618(MF:virus receptor activity)	-
P02042	1.254864	0.002052155	Hemoglobin subunit delta	3045	HBD	GO:0007596(BP:blood coagulation);GO:0098869(BP:cellular oxidant detoxification);GO:0042744(BP:hydrogen peroxide catabolic process);GO:0051291(BP:protein heterooligomerization);GO:0072562(CC:blood microparticle);GO:0005829(CC:cytosol);GO:0031838(CC:haptoglobin-hemoglobin complex);GO:0005833(CC:hemoglobin complex);GO:0020037(MF:heme binding);GO:0031721(MF:hemoglobin alpha binding);GO:0046872(MF:metal ion binding);GO:0043177(MF:organic acid binding);GO:0019825(MF:oxygen binding);GO:0005344(MF:oxygen carrier activity)	-
P01034	1.25431	0.018390783	Cystatin-C	1471	CST3	"GO:0006915(BP:apoptotic process);GO:0007420(BP:brain development);GO:0044267(BP:cellular protein metabolic process);GO:0070301(BP:cellular response to hydrogen peroxide);GO:0042747(BP:circadian sleep/wake cycle, REM sleep);GO:0006952(BP:defense response);GO:0007566(BP:embryo implantation);GO:0001654(BP:eye development);GO:0060313(BP:negative regulation of blood vessel remodeling);GO:0060548(BP:negative regulation of cell death);GO:0010711(BP:negative regulation of collagen catabolic process);GO:0060311(BP:negative regulation of elastin catabolic process);GO:0010716(BP:negative regulation of extracellular matrix disassembly);GO:0010466(BP:negative regulation of peptidase activity);GO:0045861(BP:negative regulation of proteolysis);GO:0043312(BP:neutrophil degranulation);GO:0008284(BP:positive regulation of cell proliferation);GO:0045740(BP:positive regulation of DNA replication);GO:0043687(BP:post-translational protein modification);GO:0043067(BP:regulation of programmed cell death);GO:0034103(BP:regulation of tissue remodeling);GO:0048678(BP:response to axon injury);GO:0009743(BP:response to carbohydrate);GO:0032355(BP:response to estradiol);GO:0001666(BP:response to hypoxia);GO:0031667(BP:response to nutrient levels);GO:0007431(BP:salivary gland development);GO:0060009(BP:Sertoli cell development);GO:0097435(BP:supramolecular fiber organization);GO:0030424(CC:axon);GO:0005604(CC:basement membrane);GO:0043292(CC:contractile fiber);GO:0005783(CC:endoplasmic reticulum);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1904813(CC:ficolin-1-rich granule lumen);GO:0005794(CC:Golgi apparatus);GO:0005764(CC:lysosome);GO:0005771(CC:multivesicular body);GO:0043025(CC:neuronal cell body);GO:0031965(CC:nuclear membrane);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:1904724(CC:tertiary granule lumen);GO:0001540(MF:amyloid-beta binding);GO:0004869(MF:cysteine-type endopeptidase inhibitor activity);GO:0004866(MF:endopeptidase inhibitor activity);GO:0042802(MF:identical protein binding);GO:0030414(MF:peptidase inhibitor activity);GO:0002020(MF:protease binding)"	hsa04970(Salivary secretion)
O60488	1.254251	0.000964579	Long-chain-fatty-acid--CoA ligase 4	2182	ACSL4	GO:0060996(BP:dendritic spine development);GO:0060136(BP:embryonic process involved in female pregnancy);GO:0015908(BP:fatty acid transport);GO:0008610(BP:lipid biosynthetic process);GO:0006629(BP:lipid metabolic process);GO:0035338(BP:long-chain fatty-acyl-CoA biosynthetic process);GO:0032307(BP:negative regulation of prostaglandin secretion);GO:0030307(BP:positive regulation of cell growth);GO:0070672(BP:response to interleukin-15);GO:0007584(BP:response to nutrient);GO:0019432(BP:triglyceride biosynthetic process);GO:0005737(CC:cytoplasm);GO:0005789(CC:endoplasmic reticulum membrane);GO:0070062(CC:extracellular exosome);GO:0016021(CC:integral component of membrane);GO:0005811(CC:lipid droplet);GO:0016020(CC:membrane);GO:0044233(CC:ER-mitochondrion membrane contact site);GO:0005741(CC:mitochondrial outer membrane);GO:0043025(CC:neuronal cell body);GO:0005778(CC:peroxisomal membrane);GO:0047676(MF:arachidonate-CoA ligase activity);GO:0005524(MF:ATP binding);GO:0102391(MF:decanoate-CoA ligase activity);GO:0004467(MF:long-chain fatty acid-CoA ligase activity);GO:0031957(MF:very long-chain fatty acid-CoA ligase activity)	hsa04714(Thermogenesis);hsa00071(Fatty acid degradation);hsa04216(Ferroptosis);hsa03320(PPAR signaling pathway);hsa04920(Adipocytokine signaling pathway);hsa04146(Peroxisome);hsa00061(Fatty acid biosynthesis)
O95070	1.252832	0.013072605	Protein YIF1A	10897	YIF1A	GO:0036498(BP:IRE1-mediated unfolded protein response);GO:0015031(BP:protein transport);GO:0016192(BP:vesicle-mediated transport);GO:0030134(CC:COPII-coated ER to Golgi transport vesicle);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005793(CC:endoplasmic reticulum-Golgi intermediate compartment);GO:0030173(CC:integral component of Golgi membrane)	-
Q9Y6C9	1.252002	0.048580071	Mitochondrial carrier homolog 2	23788	MTCH2	GO:0043065(BP:positive regulation of apoptotic process);GO:0070585(BP:protein localization to mitochondrion);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005743(CC:mitochondrial inner membrane);GO:0005739(CC:mitochondrion);GO:0005634(CC:nucleus)	-
Q7Z5L9	1.251882	0.004326819	Interferon regulatory factor 2-binding protein 2	359948	IRF2BP2	"GO:0002327(BP:immature B cell differentiation);GO:0005737(CC:cytoplasm);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0001228(MF:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding);GO:0046872(MF:metal ion binding);GO:0000977(MF:RNA polymerase II regulatory region sequence-specific DNA binding)"	-
P17813	1.250963	0.000228615	Endoglin	2022	ENG	"GO:0048844(BP:artery morphogenesis);GO:0055009(BP:atrial cardiac muscle tissue morphogenesis);GO:1905222(BP:atrioventricular canal morphogenesis);GO:0030509(BP:BMP signaling pathway);GO:0060348(BP:bone development);GO:0001569(BP:branching involved in blood vessel morphogenesis);GO:0003209(BP:cardiac atrium morphogenesis);GO:0003208(BP:cardiac ventricle morphogenesis);GO:0007155(BP:cell adhesion);GO:0060326(BP:cell chemotaxis);GO:0016477(BP:cell migration);GO:0003273(BP:cell migration involved in endocardial cushion formation);GO:0048870(BP:cell motility);GO:0071260(BP:cellular response to mechanical stimulus);GO:0022009(BP:central nervous system vasculogenesis);GO:0001300(BP:chronological cell aging);GO:0070483(BP:detection of hypoxia);GO:0035912(BP:dorsal aorta morphogenesis);GO:0003203(BP:endocardial cushion morphogenesis);GO:0003198(BP:epithelial to mesenchymal transition involved in endocardial cushion formation);GO:0070278(BP:extracellular matrix constituent secretion);GO:0022617(BP:extracellular matrix disassembly);GO:0001947(BP:heart looping);GO:0030336(BP:negative regulation of cell migration);GO:0001937(BP:negative regulation of endothelial cell proliferation);GO:0010629(BP:negative regulation of gene expression);GO:0051001(BP:negative regulation of nitric-oxide synthase activity);GO:0060394(BP:negative regulation of pathway-restricted SMAD protein phosphorylation);GO:0031953(BP:negative regulation of protein autophosphorylation);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0030512(BP:negative regulation of transforming growth factor beta receptor signaling pathway);GO:0003148(BP:outflow tract septum morphogenesis);GO:0045766(BP:positive regulation of angiogenesis);GO:0030513(BP:positive regulation of BMP signaling pathway);GO:0032967(BP:positive regulation of collagen biosynthetic process);GO:1905007(BP:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation);GO:0010862(BP:positive regulation of pathway-restricted SMAD protein phosphorylation);GO:0051897(BP:positive regulation of protein kinase B signaling);GO:0001934(BP:positive regulation of protein phosphorylation);GO:0003084(BP:positive regulation of systemic arterial blood pressure);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:1905065(BP:positive regulation of vascular smooth muscle cell differentiation);GO:0030155(BP:regulation of cell adhesion);GO:0042127(BP:regulation of cell proliferation);GO:0042325(BP:regulation of phosphorylation);GO:0006355(BP:regulation of transcription, DNA-templated);GO:0017015(BP:regulation of transforming growth factor beta receptor signaling pathway);GO:0031960(BP:response to corticosteroid);GO:0042493(BP:response to drug);GO:0001666(BP:response to hypoxia);GO:0071559(BP:response to transforming growth factor beta);GO:0048745(BP:smooth muscle tissue development);GO:0007179(BP:transforming growth factor beta receptor signaling pathway);GO:0097084(BP:vascular smooth muscle cell development);GO:0001570(BP:vasculogenesis);GO:0048845(BP:venous blood vessel morphogenesis);GO:0003222(BP:ventricular trabecula myocardium morphogenesis);GO:0042060(BP:wound healing);GO:0009986(CC:cell surface);GO:0072563(CC:endothelial microparticle);GO:0009897(CC:external side of plasma membrane);GO:0005615(CC:extracellular space);GO:0005925(CC:focal adhesion);GO:0016021(CC:integral component of membrane);GO:0043235(CC:receptor complex);GO:0048185(MF:activin binding);GO:0005534(MF:galactose binding);GO:0005539(MF:glycosaminoglycan binding);GO:0042802(MF:identical protein binding);GO:0042803(MF:protein homodimerization activity);GO:0050431(MF:transforming growth factor beta binding);GO:0005072(MF:transforming growth factor beta receptor, cytoplasmic mediator activity);GO:0005024(MF:transforming growth factor beta-activated receptor activity);GO:0004888(MF:transmembrane signaling receptor activity);GO:0034713(MF:type I transforming growth factor beta receptor binding);GO:0005114(MF:type II transforming growth factor beta receptor binding)"	-
P05362	1.250568	0.000531784	Intercellular adhesion molecule 1	3383	ICAM1	GO:0002438(BP:acute inflammatory response to antigenic stimulus);GO:0044406(BP:adhesion of symbiont to host);GO:0007155(BP:cell adhesion);GO:0033627(BP:cell adhesion mediated by integrin);GO:0007569(BP:cell aging);GO:0071312(BP:cellular response to alkaloid);GO:1904646(BP:cellular response to amyloid-beta);GO:0071549(BP:cellular response to dexamethasone stimulus);GO:0071333(BP:cellular response to glucose stimulus);GO:0071456(BP:cellular response to hypoxia);GO:0071347(BP:cellular response to interleukin-1);GO:0071354(BP:cellular response to interleukin-6);GO:1990830(BP:cellular response to leukemia inhibitory factor);GO:0071222(BP:cellular response to lipopolysaccharide);GO:0031669(BP:cellular response to nutrient levels);GO:0071356(BP:cellular response to tumor necrosis factor);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0061028(BP:establishment of endothelial barrier);GO:0090557(BP:establishment of endothelial intestinal barrier);GO:0097368(BP:establishment of Sertoli cell barrier);GO:0030198(BP:extracellular matrix organization);GO:0007157(BP:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules);GO:0060333(BP:interferon-gamma-mediated signaling pathway);GO:0007159(BP:leukocyte cell-cell adhesion);GO:0050900(BP:leukocyte migration);GO:0022614(BP:membrane to membrane docking);GO:0051926(BP:negative regulation of calcium ion transport);GO:2000352(BP:negative regulation of endothelial cell apoptotic process);GO:1902042(BP:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors);GO:0001541(BP:ovarian follicle development);GO:0030838(BP:positive regulation of actin filament polymerization);GO:0002693(BP:positive regulation of cellular extravasation);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:0043547(BP:positive regulation of GTPase activity);GO:1904996(BP:positive regulation of leukocyte adhesion to vascular endothelial cell);GO:0051092(BP:positive regulation of NF-kappaB transcription factor activity);GO:0045429(BP:positive regulation of nitric oxide biosynthetic process);GO:0050731(BP:positive regulation of peptidyl-tyrosine phosphorylation);GO:0045907(BP:positive regulation of vasoconstriction);GO:0046813(BP:receptor-mediated virion attachment to host cell);GO:0008360(BP:regulation of cell shape);GO:0050776(BP:regulation of immune response);GO:0001910(BP:regulation of leukocyte mediated cytotoxicity);GO:1900027(BP:regulation of ruffle assembly);GO:0043200(BP:response to amino acid);GO:0001975(BP:response to amphetamine);GO:0046688(BP:response to copper ion);GO:0045471(BP:response to ethanol);GO:0034698(BP:response to gonadotropin);GO:0032868(BP:response to insulin);GO:0010212(BP:response to ionizing radiation);GO:0010477(BP:response to sulfur dioxide);GO:0007605(BP:sensory perception of sound);GO:0002291(BP:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell);GO:0002457(BP:T cell antigen processing and presentation);GO:0072683(BP:T cell extravasation);GO:0009986(CC:cell surface);GO:0009897(CC:external side of plasma membrane);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0005925(CC:focal adhesion);GO:0001772(CC:immunological synapse);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0045121(CC:membrane raft);GO:0005886(CC:plasma membrane);GO:0005178(MF:integrin binding);GO:0038023(MF:signaling receptor activity);GO:0004888(MF:transmembrane signaling receptor activity);GO:0001618(MF:virus receptor activity)	hsa05164(Influenza A);hsa05416(Viral myocarditis);hsa05166(Human T-cell leukemia virus 1 infection);hsa05144(Malaria);hsa04668(TNF signaling pathway);hsa05167(Kaposi sarcoma-associated herpesvirus infection);hsa04514(Cell adhesion molecules (CAMs));hsa05418(Fluid shear stress and atherosclerosis);hsa04650(Natural killer cell mediated cytotoxicity);hsa04670(Leukocyte transendothelial migration);hsa05143(African trypanosomiasis);hsa05323(Rheumatoid arthritis);hsa04933(AGE-RAGE signaling pathway in diabetic complications);hsa05169(Epstein-Barr virus infection);hsa05150(Staphylococcus aureus infection);hsa04064(NF-kappa B signaling pathway)
P48509	1.248036	0.012461277	CD151 antigen	977	CD151	"GO:0007155(BP:cell adhesion);GO:0007166(BP:cell surface receptor signaling pathway);GO:0031581(BP:hemidesmosome assembly);GO:0030335(BP:positive regulation of cell migration);GO:0045807(BP:positive regulation of endocytosis);GO:0042098(BP:T cell proliferation);GO:0044319(BP:wound healing, spreading of cells);GO:0005604(CC:basement membrane);GO:0009986(CC:cell surface);GO:0005829(CC:cytosol);GO:0005925(CC:focal adhesion);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0005178(MF:integrin binding)"	-
P28827	1.247886	0.001346782	Receptor-type tyrosine-protein phosphatase mu	5797	PTPRM	GO:0007156(BP:homophilic cell adhesion via plasma membrane adhesion molecules);GO:0016525(BP:negative regulation of angiogenesis);GO:0010596(BP:negative regulation of endothelial cell migration);GO:0001937(BP:negative regulation of endothelial cell proliferation);GO:0031175(BP:neuron projection development);GO:0097755(BP:positive regulation of blood vessel diameter);GO:0006470(BP:protein dephosphorylation);GO:0042493(BP:response to drug);GO:0010842(BP:retina layer formation);GO:0031290(BP:retinal ganglion cell axon guidance);GO:0007165(BP:signal transduction);GO:0005913(CC:cell-cell adherens junction);GO:0005911(CC:cell-cell junction);GO:0005737(CC:cytoplasm);GO:0005887(CC:integral component of plasma membrane);GO:0030027(CC:lamellipodium);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0045296(MF:cadherin binding);GO:0042802(MF:identical protein binding);GO:0004725(MF:protein tyrosine phosphatase activity);GO:0005001(MF:transmembrane receptor protein tyrosine phosphatase activity)	hsa04514(Cell adhesion molecules (CAMs));hsa04520(Adherens junction)
O75695	1.245701	0.015743494	Protein XRP2	6102	RP2	GO:0000902(BP:cell morphogenesis);GO:0006892(BP:post-Golgi vesicle-mediated transport);GO:0006457(BP:protein folding);GO:0015031(BP:protein transport);GO:0007601(BP:visual perception);GO:0005814(CC:centriole);GO:0036064(CC:ciliary basal body);GO:0005929(CC:cilium);GO:0005737(CC:cytoplasm);GO:0031410(CC:cytoplasmic vesicle);GO:0070062(CC:extracellular exosome);GO:0005794(CC:Golgi apparatus);GO:0016604(CC:nuclear body);GO:0005654(CC:nucleoplasm);GO:1990075(CC:periciliary membrane compartment);GO:0005886(CC:plasma membrane);GO:0005525(MF:GTP binding);GO:0005096(MF:GTPase activator activity);GO:0000287(MF:magnesium ion binding);GO:0051082(MF:unfolded protein binding)	-
O75554	1.244011	0.000766555	WW domain-binding protein 4	11193	WBP4	"GO:0045292(BP:mRNA cis splicing, via spliceosome);GO:0000398(BP:mRNA splicing, via spliceosome);GO:0016607(CC:nuclear speck);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0071005(CC:U2-type precatalytic spliceosome);GO:0003676(MF:nucleic acid binding);GO:0070064(MF:proline-rich region binding);GO:0008270(MF:zinc ion binding)"	-
Q5VUA4	1.241083	0.012809986	Zinc finger protein 318	24149	ZNF318	"GO:0051321(BP:meiotic cell cycle);GO:0045892(BP:negative regulation of transcription, DNA-templated);GO:0045893(BP:positive regulation of transcription, DNA-templated);GO:0005829(CC:cytosol);GO:0005654(CC:nucleoplasm);GO:0003676(MF:nucleic acid binding);GO:0042803(MF:protein homodimerization activity);GO:0008270(MF:zinc ion binding)"	-
P54710	1.233984	0.048008718	Sodium/potassium-transporting ATPase subunit gamma	486	FXYD2	GO:0090662(BP:ATP hydrolysis coupled transmembrane transport);GO:0034220(BP:ion transmembrane transport);GO:1990573(BP:potassium ion import across plasma membrane);GO:1903779(BP:regulation of cardiac conduction);GO:2000649(BP:regulation of sodium ion transmembrane transporter activity);GO:0036376(BP:sodium ion export across plasma membrane);GO:0070062(CC:extracellular exosome);GO:0005886(CC:plasma membrane);GO:0005890(CC:sodium:potassium-exchanging ATPase complex);GO:0099106(MF:ion channel regulator activity);GO:0017080(MF:sodium channel regulator activity);GO:0005391(MF:sodium:potassium-exchanging ATPase activity);GO:0005215(MF:transporter activity)	hsa04024(cAMP signaling pathway);hsa04961(Endocrine and other factor-regulated calcium reabsorption);hsa04973(Carbohydrate digestion and absorption);hsa04970(Salivary secretion);hsa04964(Proximal tubule bicarbonate reclamation);hsa04978(Mineral absorption);hsa04960(Aldosterone-regulated sodium reabsorption);hsa04918(Thyroid hormone synthesis);hsa04261(Adrenergic signaling in cardiomyocytes);hsa04911(Insulin secretion);hsa04974(Protein digestion and absorption);hsa04919(Thyroid hormone signaling pathway);hsa04260(Cardiac muscle contraction);hsa04972(Pancreatic secretion);hsa04976(Bile secretion);hsa04022(cGMP-PKG signaling pathway)
Q9Y3S2	1.232354	0.017457453	Zinc finger protein 330	27309	ZNF330	"GO:0000775(CC:chromosome, centromeric region);GO:0030496(CC:midbody);GO:0005730(CC:nucleolus);GO:0046872(MF:metal ion binding);GO:0008270(MF:zinc ion binding)"	-
P19320	1.230842	0.000425365	Vascular cell adhesion protein 1	7412	VCAM1	GO:0002526(BP:acute inflammatory response);GO:0007568(BP:aging);GO:0009308(BP:amine metabolic process);GO:0030183(BP:B cell differentiation);GO:0035584(BP:calcium-mediated signaling using intracellular calcium source);GO:0060945(BP:cardiac neuron differentiation);GO:0007155(BP:cell adhesion);GO:0060326(BP:cell chemotaxis);GO:0140039(BP:cell-cell adhesion in response to extracellular stimulus);GO:0007160(BP:cell-matrix adhesion);GO:1904646(BP:cellular response to amyloid-beta);GO:0071356(BP:cellular response to tumor necrosis factor);GO:0035924(BP:cellular response to vascular endothelial growth factor stimulus);GO:0002544(BP:chronic inflammatory response);GO:0019221(BP:cytokine-mediated signaling pathway);GO:0030198(BP:extracellular matrix organization);GO:0007157(BP:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules);GO:0034113(BP:heterotypic cell-cell adhesion);GO:0060384(BP:innervation);GO:0060333(BP:interferon-gamma-mediated signaling pathway);GO:0007159(BP:leukocyte cell-cell adhesion);GO:0050901(BP:leukocyte tethering or rolling);GO:0022614(BP:membrane to membrane docking);GO:0042102(BP:positive regulation of T cell proliferation);GO:0050776(BP:regulation of immune response);GO:0045471(BP:response to ethanol);GO:0001666(BP:response to hypoxia);GO:0010212(BP:response to ionizing radiation);GO:0032496(BP:response to lipopolysaccharide);GO:0035094(BP:response to nicotine);GO:0007584(BP:response to nutrient);GO:0010043(BP:response to zinc ion);GO:0071065(CC:alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex);GO:0045177(CC:apical part of cell);GO:0009986(CC:cell surface);GO:0005769(CC:early endosome);GO:0005783(CC:endoplasmic reticulum);GO:0009897(CC:external side of plasma membrane);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0030175(CC:filopodium);GO:0005794(CC:Golgi apparatus);GO:0005887(CC:integral component of plasma membrane);GO:0005902(CC:microvillus);GO:0005886(CC:plasma membrane);GO:0002102(CC:podosome);GO:0042383(CC:sarcolemma);GO:0050839(MF:cell adhesion molecule binding);GO:0005178(MF:integrin binding);GO:0008131(MF:primary amine oxidase activity)	hsa04064(NF-kappa B signaling pathway);hsa05418(Fluid shear stress and atherosclerosis);hsa04670(Leukocyte transendothelial migration);hsa05166(Human T-cell leukemia virus 1 infection);hsa04933(AGE-RAGE signaling pathway in diabetic complications);hsa05143(African trypanosomiasis);hsa04514(Cell adhesion molecules (CAMs));hsa04668(TNF signaling pathway);hsa05144(Malaria)
P08581	1.229163	0.009680302	Hepatocyte growth factor receptor	4233	MET	GO:0048754(BP:branching morphogenesis of an epithelial tube);GO:0016477(BP:cell migration);GO:0008283(BP:cell proliferation);GO:0007166(BP:cell surface receptor signaling pathway);GO:0001886(BP:endothelial cell morphogenesis);GO:0035635(BP:entry of bacterium into host cell);GO:0061436(BP:establishment of skin barrier);GO:0001889(BP:liver development);GO:0000165(BP:MAPK cascade);GO:0010507(BP:negative regulation of autophagy);GO:1905098(BP:negative regulation of guanyl-nucleotide exchange factor activity);GO:1901299(BP:negative regulation of hydrogen peroxide-mediated programmed cell death);GO:0035024(BP:negative regulation of Rho protein signal transduction);GO:0051497(BP:negative regulation of stress fiber assembly);GO:0070495(BP:negative regulation of thrombin-activated receptor signaling pathway);GO:0007399(BP:nervous system development);GO:0030182(BP:neuron differentiation);GO:0031016(BP:pancreas development);GO:0006909(BP:phagocytosis);GO:0050918(BP:positive chemotaxis);GO:2001028(BP:positive regulation of endothelial cell chemotaxis);GO:0031116(BP:positive regulation of microtubule polymerization);GO:0051897(BP:positive regulation of protein kinase B signaling);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0071526(BP:semaphorin-plexin signaling pathway);GO:0007165(BP:signal transduction);GO:0007169(BP:transmembrane receptor protein tyrosine kinase signaling pathway);GO:0016055(BP:Wnt signaling pathway);GO:0009925(CC:basal plasma membrane);GO:0009986(CC:cell surface);GO:0005576(CC:extracellular region);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0043235(CC:receptor complex);GO:0005524(MF:ATP binding);GO:0005008(MF:hepatocyte growth factor-activated receptor activity);GO:0042802(MF:identical protein binding);GO:0019903(MF:protein phosphatase binding);GO:0004713(MF:protein tyrosine kinase activity);GO:0004714(MF:transmembrane receptor protein tyrosine kinase activity);GO:0017147(MF:Wnt-protein binding)	hsa05206(MicroRNAs in cancer);hsa05225(Hepatocellular carcinoma);hsa05200(Pathways in cancer);hsa04360(Axon guidance);hsa05230(Central carbon metabolism in cancer);hsa05226(Gastric cancer);hsa05120(Epithelial cell signaling in Helicobacter pylori infection);hsa04151(PI3K-Akt signaling pathway);hsa04014(Ras signaling pathway);hsa05205(Proteoglycans in cancer);hsa04520(Adherens junction);hsa05144(Malaria);hsa05218(Melanoma);hsa04010(MAPK signaling pathway);hsa05211(Renal cell carcinoma);hsa05202(Transcriptional misregulation in cancer);hsa04015(Rap1 signaling pathway);hsa05100(Bacterial invasion of epithelial cells);hsa01521(EGFR tyrosine kinase inhibitor resistance);hsa04510(Focal adhesion)
P13497	1.227579	0.002026534	Bone morphogenetic protein 1	649	BMP1	GO:0001502(BP:cartilage condensation);GO:0030154(BP:cell differentiation);GO:0022617(BP:extracellular matrix disassembly);GO:0034380(BP:high-density lipoprotein particle assembly);GO:0007275(BP:multicellular organism development);GO:0001503(BP:ossification);GO:0061036(BP:positive regulation of cartilage development);GO:0006508(BP:proteolysis);GO:0001501(BP:skeletal system development);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005794(CC:Golgi apparatus);GO:0031982(CC:vesicle);GO:0005509(MF:calcium ion binding);GO:0005125(MF:cytokine activity);GO:0008083(MF:growth factor activity);GO:0042802(MF:identical protein binding);GO:0004222(MF:metalloendopeptidase activity);GO:0008237(MF:metallopeptidase activity);GO:0008233(MF:peptidase activity);GO:0008270(MF:zinc ion binding)	-
P53602	1.22708	0.013517008	Diphosphomevalonate decarboxylase	4597	MVD	"GO:0006695(BP:cholesterol biosynthetic process);GO:0006489(BP:dolichyl diphosphate biosynthetic process);GO:0019287(BP:isopentenyl diphosphate biosynthetic process, mevalonate pathway);GO:0008299(BP:isoprenoid biosynthetic process);GO:0008284(BP:positive regulation of cell proliferation);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0005829(CC:cytosol);GO:0005524(MF:ATP binding);GO:0004163(MF:diphosphomevalonate decarboxylase activity);GO:0030544(MF:Hsp70 protein binding);GO:0042803(MF:protein homodimerization activity)"	hsa00900(Terpenoid backbone biosynthesis)
O75326	1.226751	0.00245247	Semaphorin-7A	8482	SEMA7A	GO:0048675(BP:axon extension);GO:0006955(BP:immune response);GO:0006954(BP:inflammatory response);GO:0007229(BP:integrin-mediated signaling pathway);GO:0050919(BP:negative chemotaxis);GO:0048843(BP:negative regulation of axon extension involved in axon guidance);GO:0001755(BP:neural crest cell migration);GO:0021988(BP:olfactory lobe development);GO:0001649(BP:osteoblast differentiation);GO:0045773(BP:positive regulation of axon extension);GO:0030335(BP:positive regulation of cell migration);GO:0070374(BP:positive regulation of ERK1 and ERK2 cascade);GO:0060907(BP:positive regulation of macrophage cytokine production);GO:0050727(BP:regulation of inflammatory response);GO:0071526(BP:semaphorin-plexin signaling pathway);GO:0031225(CC:anchored component of membrane);GO:0009897(CC:external side of plasma membrane);GO:0005615(CC:extracellular space);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0045499(MF:chemorepellent activity);GO:0005178(MF:integrin binding);GO:0038191(MF:neuropilin binding);GO:0030215(MF:semaphorin receptor binding)	hsa04360(Axon guidance)
Q16787	1.225285	0.006063335	Laminin subunit alpha-3	3909	LAMA3	GO:0007155(BP:cell adhesion);GO:0035987(BP:endodermal cell differentiation);GO:0008544(BP:epidermis development);GO:0030198(BP:extracellular matrix organization);GO:0031581(BP:hemidesmosome assembly);GO:0030155(BP:regulation of cell adhesion);GO:0030334(BP:regulation of cell migration);GO:0045995(BP:regulation of embryonic development);GO:0005604(CC:basement membrane);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005610(CC:laminin-5 complex);GO:0005201(MF:extracellular matrix structural constituent);GO:0005102(MF:signaling receptor binding);GO:0005198(MF:structural molecule activity)	hsa05145(Toxoplasmosis);hsa04510(Focal adhesion);hsa05165(Human papillomavirus infection);hsa05222(Small cell lung cancer);hsa04151(PI3K-Akt signaling pathway);hsa05146(Amoebiasis);hsa04512(ECM-receptor interaction);hsa05200(Pathways in cancer)
O95573	1.225217	0.000202571	Long-chain-fatty-acid--CoA ligase 3	2181	ACSL3	GO:0007420(BP:brain development);GO:0006633(BP:fatty acid biosynthetic process);GO:0044539(BP:long-chain fatty acid import);GO:0035338(BP:long-chain fatty-acyl-CoA biosynthetic process);GO:0042998(BP:positive regulation of Golgi to plasma membrane protein transport);GO:2001247(BP:positive regulation of phosphatidylcholine biosynthetic process);GO:0051047(BP:positive regulation of secretion);GO:0007584(BP:response to nutrient);GO:0014070(BP:response to organic cyclic compound);GO:0034379(BP:very-low-density lipoprotein particle assembly);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005794(CC:Golgi apparatus);GO:0016021(CC:integral component of membrane);GO:0005811(CC:lipid droplet);GO:0016020(CC:membrane);GO:0005741(CC:mitochondrial outer membrane);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005778(CC:peroxisomal membrane);GO:0005524(MF:ATP binding);GO:0102391(MF:decanoate-CoA ligase activity);GO:0004467(MF:long-chain fatty acid-CoA ligase activity);GO:0019904(MF:protein domain specific binding);GO:0019901(MF:protein kinase binding)	hsa04714(Thermogenesis);hsa00071(Fatty acid degradation);hsa04216(Ferroptosis);hsa04146(Peroxisome);hsa04920(Adipocytokine signaling pathway);hsa03320(PPAR signaling pathway);hsa00061(Fatty acid biosynthesis)
Q13433	1.224737	0.009977231	Zinc transporter ZIP6	25800	SLC39A6	GO:0006882(BP:cellular zinc ion homeostasis);GO:0071578(BP:zinc ion import across plasma membrane);GO:0071577(BP:zinc ion transmembrane transport);GO:0009986(CC:cell surface);GO:0005783(CC:endoplasmic reticulum);GO:0005887(CC:integral component of plasma membrane);GO:0031258(CC:lamellipodium membrane);GO:0005886(CC:plasma membrane);GO:0005385(MF:zinc ion transmembrane transporter activity)	-
O60427	1.224173	0.025618822	Acyl-CoA (8-3)-desaturase	3992	FADS1	"GO:0036109(BP:alpha-linolenic acid metabolic process);GO:0007267(BP:cell-cell signaling);GO:0009267(BP:cellular response to starvation);GO:0046456(BP:icosanoid biosynthetic process);GO:0043651(BP:linoleic acid metabolic process);GO:0008654(BP:phospholipid biosynthetic process);GO:0045595(BP:regulation of cell differentiation);GO:0019216(BP:regulation of lipid metabolic process);GO:0006355(BP:regulation of transcription, DNA-templated);GO:0006636(BP:unsaturated fatty acid biosynthetic process);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0016020(CC:membrane);GO:0005739(CC:mitochondrion);GO:0000248(MF:C-5 sterol desaturase activity);GO:0045485(MF:omega-6 fatty acid desaturase activity);GO:0016491(MF:oxidoreductase activity)"	hsa01040(Biosynthesis of unsaturated fatty acids)
P27105	1.222666	0.040815969	Erythrocyte band 7 integral membrane protein	2040	STOM	GO:0043312(BP:neutrophil degranulation);GO:0044829(BP:positive regulation by host of viral genome replication);GO:0090314(BP:positive regulation of protein targeting to membrane);GO:0051260(BP:protein homooligomerization);GO:1901585(BP:regulation of acid-sensing ion channel activity);GO:0035577(CC:azurophil granule membrane);GO:0072562(CC:blood microparticle);GO:0005856(CC:cytoskeleton);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0005887(CC:integral component of plasma membrane);GO:0042470(CC:melanosome);GO:0016020(CC:membrane);GO:0045121(CC:membrane raft);GO:0005739(CC:mitochondrion);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0035579(CC:specific granule membrane);GO:0070821(CC:tertiary granule membrane);GO:0031982(CC:vesicle);GO:0042803(MF:protein homodimerization activity);GO:0070063(MF:RNA polymerase binding)	-
P78410	1.22135	0.020494039	Butyrophilin subfamily 3 member A2	11118	BTN3A2	GO:0072643(BP:interferon-gamma secretion);GO:0050776(BP:regulation of immune response);GO:0002456(BP:T cell mediated immunity);GO:0050852(BP:T cell receptor signaling pathway);GO:0009897(CC:external side of plasma membrane);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0005102(MF:signaling receptor binding)	-
O43752	1.220598	0.00438292	Syntaxin-6	10228	STX6	"GO:0032456(BP:endocytic recycling);GO:0007032(BP:endosome organization);GO:0090161(BP:Golgi ribbon formation);GO:0048193(BP:Golgi vesicle transport);GO:0006886(BP:intracellular protein transport);GO:1903827(BP:regulation of cellular protein localization);GO:0032880(BP:regulation of protein localization);GO:0042147(BP:retrograde transport, endosome to Golgi);GO:0016189(BP:synaptic vesicle to endosome fusion);GO:0048278(BP:vesicle docking);GO:0006906(BP:vesicle fusion);GO:0030136(CC:clathrin-coated vesicle);GO:0005829(CC:cytosol);GO:0005769(CC:early endosome);GO:0012505(CC:endomembrane system);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane);GO:0030285(CC:integral component of synaptic vesicle membrane);GO:0005654(CC:nucleoplasm);GO:0048471(CC:perinuclear region of cytoplasm);GO:0045335(CC:phagocytic vesicle);GO:0005886(CC:plasma membrane);GO:0031201(CC:SNARE complex);GO:0008021(CC:synaptic vesicle);GO:0005802(CC:trans-Golgi network);GO:0032588(CC:trans-Golgi network membrane);GO:0005484(MF:SNAP receptor activity);GO:0000149(MF:SNARE binding);GO:0019905(MF:syntaxin binding)"	hsa04130(SNARE interactions in vesicular transport)
P49327	1.220417	1.51E-06	Fatty acid synthase	2194	FASN	"GO:0006084(BP:acetyl-CoA metabolic process);GO:0071353(BP:cellular response to interleukin-4);GO:0090557(BP:establishment of endothelial intestinal barrier);GO:0008611(BP:ether lipid biosynthetic process);GO:0006633(BP:fatty acid biosynthetic process);GO:0006631(BP:fatty acid metabolic process);GO:0046949(BP:fatty-acyl-CoA biosynthetic process);GO:0030879(BP:mammary gland development);GO:0030224(BP:monocyte differentiation);GO:0030223(BP:neutrophil differentiation);GO:0001649(BP:osteoblast differentiation);GO:0031325(BP:positive regulation of cellular metabolic process);GO:0045540(BP:regulation of cholesterol biosynthetic process);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0042587(CC:glycogen granule);GO:0005794(CC:Golgi apparatus);GO:0042470(CC:melanosome);GO:0016020(CC:membrane);GO:0005886(CC:plasma membrane);GO:0008659(MF:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity);GO:0047451(MF:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity);GO:0102131(MF:3-oxo-glutaryl-[acp] methyl ester reductase activity);GO:0102132(MF:3-oxo-pimeloyl-[acp] methyl ester reductase activity);GO:0004316(MF:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity);GO:0004315(MF:3-oxoacyl-[acyl-carrier-protein] synthase activity);GO:0004313(MF:[acyl-carrier-protein] S-acetyltransferase activity);GO:0004314(MF:[acyl-carrier-protein] S-malonyltransferase activity);GO:0045296(MF:cadherin binding);GO:0008144(MF:drug binding);GO:0047117(MF:enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity);GO:0016295(MF:myristoyl-[acyl-carrier-protein] hydrolase activity);GO:0070402(MF:NADPH binding);GO:0004320(MF:oleoyl-[acyl-carrier-protein] hydrolase activity);GO:0016296(MF:palmitoyl-[acyl-carrier-protein] hydrolase activity);GO:0031177(MF:phosphopantetheine binding);GO:0042803(MF:protein homodimerization activity);GO:0003723(MF:RNA binding)"	hsa04152(AMPK signaling pathway);hsa00061(Fatty acid biosynthesis);hsa04910(Insulin signaling pathway)
Q02388	1.219224	0.000511005	Collagen alpha-1(VII) chain	1294	COL7A1	GO:0007155(BP:cell adhesion);GO:0048208(BP:COPII vesicle coating);GO:0035987(BP:endodermal cell differentiation);GO:0006888(BP:ER to Golgi vesicle-mediated transport);GO:0008544(BP:epidermis development);GO:0030198(BP:extracellular matrix organization);GO:0003429(BP:growth plate cartilage chondrocyte morphogenesis);GO:0005604(CC:basement membrane);GO:0005590(CC:collagen type VII trimer);GO:0030134(CC:COPII-coated ER to Golgi transport vesicle);GO:0005788(CC:endoplasmic reticulum lumen);GO:0033116(CC:endoplasmic reticulum-Golgi intermediate compartment membrane);GO:0031012(CC:extracellular matrix);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0000139(CC:Golgi membrane);GO:0030020(MF:extracellular matrix structural constituent conferring tensile strength);GO:0004867(MF:serine-type endopeptidase inhibitor activity)	hsa04974(Protein digestion and absorption)
Q9NVC3	1.219166	0.001663698	Putative sodium-coupled neutral amino acid transporter 7	55238	SLC38A7	GO:0003333(BP:amino acid transmembrane transport);GO:0006814(BP:sodium ion transport);GO:0030424(CC:axon);GO:0016021(CC:integral component of membrane);GO:0043025(CC:neuronal cell body);GO:0015171(MF:amino acid transmembrane transporter activity);GO:0015180(MF:L-alanine transmembrane transporter activity);GO:0015179(MF:L-amino acid transmembrane transporter activity);GO:0015182(MF:L-asparagine transmembrane transporter activity);GO:0015183(MF:L-aspartate transmembrane transporter activity);GO:0005313(MF:L-glutamate transmembrane transporter activity);GO:0015186(MF:L-glutamine transmembrane transporter activity);GO:0005290(MF:L-histidine transmembrane transporter activity);GO:0015190(MF:L-leucine transmembrane transporter activity);GO:0015191(MF:L-methionine transmembrane transporter activity);GO:0015194(MF:L-serine transmembrane transporter activity)	-
P08473	1.218549	0.000626501	Neprilysin	4311	MME	GO:0007568(BP:aging);GO:0097242(BP:amyloid-beta clearance);GO:0050435(BP:amyloid-beta metabolic process);GO:0002003(BP:angiotensin maturation);GO:0071345(BP:cellular response to cytokine stimulus);GO:0071492(BP:cellular response to UV-A);GO:0071493(BP:cellular response to UV-B);GO:0046449(BP:creatinine metabolic process);GO:0001822(BP:kidney development);GO:0007611(BP:learning or memory);GO:0030324(BP:lung development);GO:0061837(BP:neuropeptide processing);GO:0043312(BP:neutrophil degranulation);GO:0006518(BP:peptide metabolic process);GO:0001890(BP:placenta development);GO:1900273(BP:positive regulation of long-term synaptic potentiation);GO:0050769(BP:positive regulation of neurogenesis);GO:0006508(BP:proteolysis);GO:0090399(BP:replicative senescence);GO:0019233(BP:sensory perception of pain);GO:0030424(CC:axon);GO:0005903(CC:brush border);GO:0009986(CC:cell surface);GO:0005737(CC:cytoplasm);GO:0031410(CC:cytoplasmic vesicle);GO:0030425(CC:dendrite);GO:0005769(CC:early endosome);GO:0070062(CC:extracellular exosome);GO:0005925(CC:focal adhesion);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0045121(CC:membrane raft);GO:0044306(CC:neuron projection terminus);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0098793(CC:presynapse);GO:0030667(CC:secretory granule membrane);GO:0045202(CC:synapse);GO:0008021(CC:synaptic vesicle);GO:0005802(CC:trans-Golgi network);GO:1901612(MF:cardiolipin binding);GO:0004175(MF:endopeptidase activity);GO:0008238(MF:exopeptidase activity);GO:0004222(MF:metalloendopeptidase activity);GO:0008237(MF:metallopeptidase activity);GO:0070012(MF:oligopeptidase activity);GO:0042277(MF:peptide binding);GO:0001786(MF:phosphatidylserine binding);GO:0042803(MF:protein homodimerization activity);GO:0008270(MF:zinc ion binding)	hsa04974(Protein digestion and absorption);hsa05010(Alzheimer disease);hsa04614(Renin-angiotensin system);hsa04640(Hematopoietic cell lineage)
Q03169	1.21752	0.024961399	Tumor necrosis factor alpha-induced protein 2	7127	TNFAIP2	GO:0001525(BP:angiogenesis);GO:0030154(BP:cell differentiation);GO:0051601(BP:exocyst localization);GO:0006887(BP:exocytosis);GO:0000145(CC:exocyst);GO:0005615(CC:extracellular space);GO:0000149(MF:SNARE binding)	-
Q9Y6K8	1.217151	0.002967176	Adenylate kinase isoenzyme 5	26289	AK5	GO:0006172(BP:ADP biosynthetic process);GO:0046034(BP:ATP metabolic process);GO:0006173(BP:dADP biosynthetic process);GO:0015949(BP:nucleobase-containing small molecule interconversion);GO:0006165(BP:nucleoside diphosphate phosphorylation);GO:0009142(BP:nucleoside triphosphate biosynthetic process);GO:0009220(BP:pyrimidine ribonucleotide biosynthetic process);GO:0005829(CC:cytosol);GO:0005815(CC:microtubule organizing center);GO:0004017(MF:adenylate kinase activity);GO:0005524(MF:ATP binding);GO:0004550(MF:nucleoside diphosphate kinase activity)	hsa00730(Thiamine metabolism);hsa00230(Purine metabolism)
Q9GZM5	1.216872	0.013987939	Protein YIPF3	25844	YIPF3	GO:0030154(BP:cell differentiation);GO:0005794(CC:Golgi apparatus);GO:0016021(CC:integral component of membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005886(CC:plasma membrane);GO:0030133(CC:transport vesicle)	-
Q9H5V8	1.215097	0.02496371	CUB domain-containing protein 1	64866	CDCP1	GO:0005576(CC:extracellular region);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane)	-
Q8IV08	1.214772	0.001932728	Phospholipase D3	23646	PLD3	GO:0016042(BP:lipid catabolic process);GO:0005789(CC:endoplasmic reticulum membrane);GO:0070062(CC:extracellular exosome);GO:0016021(CC:integral component of membrane);GO:0070290(MF:N-acylphosphatidylethanolamine-specific phospholipase D activity);GO:0004630(MF:phospholipase D activity)	hsa00565(Ether lipid metabolism);hsa00564(Glycerophospholipid metabolism)
P25942	1.211098	0.018522687	Tumor necrosis factor receptor superfamily member 5	958	CD40	GO:0042100(BP:B cell proliferation);GO:0006874(BP:cellular calcium ion homeostasis);GO:0036018(BP:cellular response to erythropoietin);GO:0071347(BP:cellular response to interleukin-1);GO:0071222(BP:cellular response to lipopolysaccharide);GO:0071260(BP:cellular response to mechanical stimulus);GO:0042832(BP:defense response to protozoan);GO:0051607(BP:defense response to virus);GO:0002768(BP:immune response-regulating cell surface receptor signaling pathway);GO:0006954(BP:inflammatory response);GO:0030168(BP:platelet activation);GO:0045766(BP:positive regulation of angiogenesis);GO:0030890(BP:positive regulation of B cell proliferation);GO:0043536(BP:positive regulation of blood vessel endothelial cell migration);GO:2000353(BP:positive regulation of endothelial cell apoptotic process);GO:0043547(BP:positive regulation of GTPase activity);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0032735(BP:positive regulation of interleukin-12 production);GO:0048304(BP:positive regulation of isotype switching to IgG isotypes);GO:0043406(BP:positive regulation of MAP kinase activity);GO:0051092(BP:positive regulation of NF-kappaB transcription factor activity);GO:0090037(BP:positive regulation of protein kinase C signaling);GO:0001934(BP:positive regulation of protein phosphorylation);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0042531(BP:positive regulation of tyrosine phosphorylation of STAT protein);GO:0043491(BP:protein kinase B signaling);GO:0065003(BP:protein-containing complex assembly);GO:0050776(BP:regulation of immune response);GO:0051023(BP:regulation of immunoglobulin secretion);GO:0033590(BP:response to cobalamin);GO:0034341(BP:response to interferon-gamma);GO:1901652(BP:response to peptide);GO:0033209(BP:tumor necrosis factor-mediated signaling pathway);GO:0035631(CC:CD40 receptor complex);GO:0009986(CC:cell surface);GO:0005737(CC:cytoplasm);GO:0009897(CC:external side of plasma membrane);GO:0070062(CC:extracellular exosome);GO:0005887(CC:integral component of plasma membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0043196(CC:varicosity);GO:0003823(MF:antigen binding);GO:0019899(MF:enzyme binding);GO:0019904(MF:protein domain specific binding);GO:0038023(MF:signaling receptor activity);GO:0031625(MF:ubiquitin protein ligase binding)	hsa05169(Epstein-Barr virus infection);hsa04620(Toll-like receptor signaling pathway);hsa04672(Intestinal immune network for IgA production);hsa05145(Toxoplasmosis);hsa05330(Allograft rejection);hsa04064(NF-kappa B signaling pathway);hsa05310(Asthma);hsa05144(Malaria);hsa04514(Cell adhesion molecules (CAMs));hsa04060(Cytokine-cytokine receptor interaction);hsa05320(Autoimmune thyroid disease);hsa05166(Human T-cell leukemia virus 1 infection);hsa05202(Transcriptional misregulation in cancer);hsa05416(Viral myocarditis);hsa05340(Primary immunodeficiency);hsa05322(Systemic lupus erythematosus)
Q14573	1.210316	0.001094303	"Inositol 1,4,5-trisphosphate receptor type 3"	3710	ITPR3	"GO:0060402(BP:calcium ion transport into cytosol);GO:0007186(BP:G-protein coupled receptor signaling pathway);GO:0060291(BP:long-term synaptic potentiation);GO:0007613(BP:memory);GO:0030168(BP:platelet activation);GO:0007204(BP:positive regulation of cytosolic calcium ion concentration);GO:0051291(BP:protein heterooligomerization);GO:0051260(BP:protein homooligomerization);GO:1903779(BP:regulation of cardiac conduction);GO:0050796(BP:regulation of insulin secretion);GO:0051209(BP:release of sequestered calcium ion into cytosol);GO:0051592(BP:response to calcium ion);GO:0050913(BP:sensory perception of bitter taste);GO:0050916(BP:sensory perception of sweet taste);GO:0050917(BP:sensory perception of umami taste);GO:0045177(CC:apical part of cell);GO:0005903(CC:brush border);GO:0005737(CC:cytoplasm);GO:0030659(CC:cytoplasmic vesicle membrane);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0043209(CC:myelin sheath);GO:0043025(CC:neuronal cell body);GO:0005640(CC:nuclear outer membrane);GO:0005730(CC:nucleolus);GO:0005654(CC:nucleoplasm);GO:0005886(CC:plasma membrane);GO:0031095(CC:platelet dense tubular network membrane);GO:0043235(CC:receptor complex);GO:0016529(CC:sarcoplasmic reticulum);GO:0030667(CC:secretory granule membrane);GO:0005509(MF:calcium ion binding);GO:0015278(MF:calcium-release channel activity);GO:0043533(MF:inositol 1,3,4,5 tetrakisphosphate binding);GO:0070679(MF:inositol 1,4,5 trisphosphate binding);GO:0005220(MF:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity);GO:0000822(MF:inositol hexakisphosphate binding);GO:0035091(MF:phosphatidylinositol binding)"	"hsa05170(Human immunodeficiency virus 1 infection);hsa04611(Platelet activation);hsa04924(Renin secretion);hsa05163(Human cytomegalovirus infection);hsa04918(Thyroid hormone synthesis);hsa04713(Circadian entrainment);hsa04270(Vascular smooth muscle contraction);hsa04726(Serotonergic synapse);hsa04720(Long-term potentiation);hsa04915(Estrogen signaling pathway);hsa04928(Parathyroid hormone synthesis, secretion and action);hsa05167(Kaposi sarcoma-associated herpesvirus infection);hsa04970(Salivary secretion);hsa05010(Alzheimer disease);hsa04742(Taste transduction);hsa04218(Cellular senescence);hsa04625(C-type lectin receptor signaling pathway);hsa04621(NOD-like receptor signaling pathway);hsa04911(Insulin secretion);hsa04730(Long-term depression);hsa04971(Gastric acid secretion);hsa04972(Pancreatic secretion);hsa04022(cGMP-PKG signaling pathway);hsa04114(Oocyte meiosis);hsa04728(Dopaminergic synapse);hsa05205(Proteoglycans in cancer);hsa04540(Gap junction);hsa04070(Phosphatidylinositol signaling system);hsa04750(Inflammatory mediator regulation of TRP channels);hsa04371(Apelin signaling pathway);hsa04724(Glutamatergic synapse);hsa04723(Retrograde endocannabinoid signaling);hsa04921(Oxytocin signaling pathway);hsa04912(GnRH signaling pathway);hsa04927(Cortisol synthesis and secretion);hsa04922(Glucagon signaling pathway);hsa04925(Aldosterone synthesis and secretion);hsa04020(Calcium signaling pathway);hsa04210(Apoptosis);hsa04934(Cushing syndrome);hsa04725(Cholinergic synapse)"
O60476	1.210189	0.011918085	"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB"	10905	MAN1A2	"GO:1904381(BP:Golgi apparatus mannose trimming);GO:0048286(BP:lung alveolus development);GO:0006491(BP:N-glycan processing);GO:0006486(BP:protein glycosylation);GO:0007585(BP:respiratory gaseous exchange);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005794(CC:Golgi apparatus);GO:0000139(CC:Golgi membrane);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0005509(MF:calcium ion binding);GO:0004571(MF:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity)"	hsa00510(N-Glycan biosynthesis);hsa04141(Protein processing in endoplasmic reticulum)
O94868	1.209393	0.000159001	F-BAR and double SH3 domains protein 2	9873	FCHSD2	"GO:0072583(BP:clathrin-dependent endocytosis);GO:0044803(BP:multi-organism membrane organization);GO:0007274(BP:neuromuscular synaptic transmission);GO:0030838(BP:positive regulation of actin filament polymerization);GO:2000601(BP:positive regulation of Arp2/3 complex-mediated actin nucleation);GO:0015031(BP:protein transport);GO:0030833(BP:regulation of actin filament polymerization);GO:0030054(CC:cell junction);GO:0005905(CC:clathrin-coated pit);GO:0031594(CC:neuromuscular junction);GO:0005886(CC:plasma membrane);GO:0055037(CC:recycling endosome);GO:0120043(CC:stereocilium shaft);GO:0005547(MF:phosphatidylinositol-3,4,5-trisphosphate binding);GO:0043325(MF:phosphatidylinositol-3,4-bisphosphate binding)"	-
P41440	1.209318	0.013630763	Folate transporter 1	6573	SLC19A1	GO:1904447(BP:folic acid import across plasma membrane);GO:0098838(BP:reduced folate transmembrane transport);GO:0046655(BP:folic acid metabolic process);GO:0015884(BP:folic acid transport);GO:0055085(BP:transmembrane transport);GO:0016324(CC:apical plasma membrane);GO:0016323(CC:basolateral plasma membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0008518(MF:reduced folate carrier activity);GO:0005542(MF:folic acid binding);GO:0008517(MF:folic acid transmembrane transporter activity);GO:0015350(MF:methotrexate transmembrane transporter activity)	hsa04977(Vitamin digestion and absorption);hsa01523(Antifolate resistance)
P15529	1.204439	4.71E-05	Membrane cofactor protein	4179	CD46	"GO:0002250(BP:adaptive immune response);GO:0006958(BP:complement activation, classical pathway);GO:0045087(BP:innate immune response);GO:0032613(BP:interleukin-10 production);GO:0010629(BP:negative regulation of gene expression);GO:0010628(BP:positive regulation of gene expression);GO:0032733(BP:positive regulation of interleukin-10 production);GO:0043382(BP:positive regulation of memory T cell differentiation);GO:0045591(BP:positive regulation of regulatory T cell differentiation);GO:0042102(BP:positive regulation of T cell proliferation);GO:0071636(BP:positive regulation of transforming growth factor beta production);GO:0030449(BP:regulation of complement activation);GO:0008593(BP:regulation of Notch signaling pathway);GO:0035581(BP:sequestering of extracellular ligand from receptor);GO:0007338(BP:single fertilization);GO:0002456(BP:T cell mediated immunity);GO:0009986(CC:cell surface);GO:0070062(CC:extracellular exosome);GO:0005925(CC:focal adhesion);GO:0002079(CC:inner acrosomal membrane);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane);GO:0045296(MF:cadherin binding);GO:0038023(MF:signaling receptor activity);GO:0001618(MF:virus receptor activity)"	hsa04610(Complement and coagulation cascades);hsa05162(Measles)
P32004	1.202874	0.007804117	Neural cell adhesion molecule L1	3897	L1CAM	GO:0061564(BP:axon development);GO:0007411(BP:axon guidance);GO:0007155(BP:cell adhesion);GO:0016477(BP:cell migration);GO:0007160(BP:cell-matrix adhesion);GO:0006935(BP:chemotaxis);GO:0007156(BP:homophilic cell adhesion via plasma membrane adhesion molecules);GO:0050900(BP:leukocyte migration);GO:0007399(BP:nervous system development);GO:0031175(BP:neuron projection development);GO:0045773(BP:positive regulation of axon extension);GO:0050808(BP:synapse organization);GO:0030424(CC:axon);GO:0044295(CC:axonal growth cone);GO:0009986(CC:cell surface);GO:0030425(CC:dendrite);GO:0005925(CC:focal adhesion);GO:0016021(CC:integral component of membrane);GO:0043025(CC:neuronal cell body);GO:0005886(CC:plasma membrane);GO:0008046(MF:axon guidance receptor activity);GO:0019904(MF:protein domain specific binding)	hsa04514(Cell adhesion molecules (CAMs));hsa04360(Axon guidance)
Q9NS93	1.201395	0.014667181	Transmembrane 7 superfamily member 3	51768	TM7SF3	GO:0034620(BP:cellular response to unfolded protein);GO:0043069(BP:negative regulation of programmed cell death);GO:0032024(BP:positive regulation of insulin secretion);GO:0070062(CC:extracellular exosome);GO:0016021(CC:integral component of membrane);GO:0005886(CC:plasma membrane)	-
Q9ULQ1	1.200929	0.042399527	Two pore calcium channel protein 1	53373	TPCN1	GO:0034220(BP:ion transmembrane transport);GO:0010508(BP:positive regulation of autophagy);GO:0034765(BP:regulation of ion transmembrane transport);GO:0005768(CC:endosome);GO:0010008(CC:endosome membrane);GO:0016021(CC:integral component of membrane);GO:0005765(CC:lysosomal membrane);GO:0005764(CC:lysosome);GO:0042802(MF:identical protein binding);GO:0072345(MF:NAADP-sensitive calcium-release channel activity);GO:0005245(MF:voltage-gated calcium channel activity)	-
Q9Y5X1	1.200254	0.000303055	Sorting nexin-9	51429	SNX9	GO:0036089(BP:cleavage furrow formation);GO:0006897(BP:endocytosis);GO:0016197(BP:endosomal transport);GO:0006886(BP:intracellular protein transport);GO:0060988(BP:lipid tube assembly);GO:0061024(BP:membrane organization);GO:0000281(BP:mitotic cytokinesis);GO:0097320(BP:plasma membrane tubulation);GO:0030838(BP:positive regulation of actin filament polymerization);GO:0043547(BP:positive regulation of GTPase activity);GO:0051044(BP:positive regulation of membrane protein ectodomain proteolysis);GO:0045860(BP:positive regulation of protein kinase activity);GO:0032461(BP:positive regulation of protein oligomerization);GO:0006898(BP:receptor-mediated endocytosis);GO:0030136(CC:clathrin-coated vesicle);GO:0032437(CC:cuticular plate);GO:0005737(CC:cytoplasm);GO:0031410(CC:cytoplasmic vesicle);GO:0030659(CC:cytoplasmic vesicle membrane);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0031234(CC:extrinsic component of cytoplasmic side of plasma membrane);GO:0005886(CC:plasma membrane);GO:0001726(CC:ruffle);GO:0005802(CC:trans-Golgi network);GO:0005545(MF:1-phosphatidylinositol binding);GO:0071933(MF:Arp2/3 complex binding);GO:0045296(MF:cadherin binding);GO:0042802(MF:identical protein binding);GO:0035091(MF:phosphatidylinositol binding);GO:0042803(MF:protein homodimerization activity);GO:0031625(MF:ubiquitin protein ligase binding)	-
O00584	0.832074	0.009966698	Ribonuclease T2	8635	RNASET2	GO:0043312(BP:neutrophil degranulation);GO:0006401(BP:RNA catabolic process);GO:0035578(CC:azurophil granule lumen);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0004521(MF:endoribonuclease activity);GO:0004540(MF:ribonuclease activity);GO:0033897(MF:ribonuclease T2 activity);GO:0003723(MF:RNA binding)	-
P06746	0.828997	0.031325146	DNA polymerase beta	5423	POLB	"GO:0007568(BP:aging);GO:0006284(BP:base-excision repair);GO:0006286(BP:base-excision repair, base-free sugar-phosphate removal);GO:0006288(BP:base-excision repair, DNA ligation);GO:0006287(BP:base-excision repair, gap-filling);GO:0006974(BP:cellular response to DNA damage stimulus);GO:0006281(BP:DNA repair);GO:0006261(BP:DNA-dependent DNA replication);GO:0006303(BP:double-strand break repair via nonhomologous end joining);GO:0048872(BP:homeostasis of number of cells);GO:0071707(BP:immunoglobulin heavy chain V-D-J recombination);GO:0006954(BP:inflammatory response);GO:0008630(BP:intrinsic apoptotic signaling pathway in response to DNA damage);GO:0048535(BP:lymph node development);GO:0051402(BP:neuron apoptotic process);GO:0016579(BP:protein deubiquitination);GO:0006290(BP:pyrimidine dimer repair);GO:0045471(BP:response to ethanol);GO:0010332(BP:response to gamma radiation);GO:0055093(BP:response to hyperoxia);GO:0007435(BP:salivary gland morphogenesis);GO:0016446(BP:somatic hypermutation of immunoglobulin genes);GO:0048536(BP:spleen development);GO:0005737(CC:cytoplasm);GO:0005874(CC:microtubule);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0032991(CC:protein-containing complex);GO:0005876(CC:spindle microtubule);GO:0003684(MF:damaged DNA binding);GO:0003906(MF:DNA-(apurinic or apyrimidinic site) endonuclease activity);GO:0003887(MF:DNA-directed DNA polymerase activity);GO:0019899(MF:enzyme binding);GO:0016829(MF:lyase activity);GO:0046872(MF:metal ion binding);GO:0008017(MF:microtubule binding)"	hsa05203(Viral carcinogenesis);hsa03410(Base excision repair);hsa05166(Human T-cell leukemia virus 1 infection)
P06493	0.82781	0.001717054	Cyclin-dependent kinase 1	983	CDK1	"GO:0000187(BP:activation of MAPK activity);GO:0031145(BP:anaphase-promoting complex-dependent catabolic process);GO:0031100(BP:animal organ regeneration);GO:0006915(BP:apoptotic process);GO:0007569(BP:cell aging);GO:0051301(BP:cell division);GO:0016477(BP:cell migration);GO:0008283(BP:cell proliferation);GO:0070301(BP:cellular response to hydrogen peroxide);GO:0007098(BP:centrosome cycle);GO:0030261(BP:chromosome condensation);GO:0097711(BP:ciliary basal body-plasma membrane docking);GO:0006977(BP:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest);GO:0006281(BP:DNA repair);GO:0006260(BP:DNA replication);GO:0030855(BP:epithelial cell differentiation);GO:0000086(BP:G2/M transition of mitotic cell cycle);GO:0090166(BP:Golgi disassembly);GO:0000226(BP:microtubule cytoskeleton organization);GO:0044772(BP:mitotic cell cycle phase transition);GO:0007095(BP:mitotic G2 DNA damage checkpoint);GO:0007077(BP:mitotic nuclear envelope disassembly);GO:0043066(BP:negative regulation of apoptotic process);GO:0018105(BP:peptidyl-serine phosphorylation);GO:0018107(BP:peptidyl-threonine phosphorylation);GO:0060045(BP:positive regulation of cardiac muscle cell proliferation);GO:0045740(BP:positive regulation of DNA replication);GO:0010971(BP:positive regulation of G2/M transition of mitotic cell cycle);GO:0010628(BP:positive regulation of gene expression);GO:1905448(BP:positive regulation of mitochondrial ATP synthesis coupled electron transport);GO:1900182(BP:positive regulation of protein localization to nucleus);GO:0007344(BP:pronuclear fusion);GO:0016579(BP:protein deubiquitination);GO:0034501(BP:protein localization to kinetochore);GO:0006468(BP:protein phosphorylation);GO:0065003(BP:protein-containing complex assembly);GO:0042752(BP:regulation of circadian rhythm);GO:0045995(BP:regulation of embryonic development);GO:0010389(BP:regulation of G2/M transition of mitotic cell cycle);GO:1901990(BP:regulation of mitotic cell cycle phase transition);GO:0014038(BP:regulation of Schwann cell differentiation);GO:0014823(BP:response to activity);GO:0014075(BP:response to amine);GO:0048678(BP:response to axon injury);GO:0046686(BP:response to cadmium ion);GO:0046688(BP:response to copper ion);GO:0045471(BP:response to ethanol);GO:0014070(BP:response to organic cyclic compound);GO:0048511(BP:rhythmic process);GO:0006367(BP:transcription initiation from RNA polymerase II promoter);GO:0055015(BP:ventricular cardiac muscle cell development);GO:0005813(CC:centrosome);GO:0097125(CC:cyclin B1-CDK1 complex);GO:0000307(CC:cyclin-dependent protein kinase holoenzyme complex);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005789(CC:endoplasmic reticulum membrane);GO:0070062(CC:extracellular exosome);GO:0016020(CC:membrane);GO:0030496(CC:midbody);GO:0005759(CC:mitochondrial matrix);GO:0005739(CC:mitochondrion);GO:0072686(CC:mitotic spindle);GO:0000784(CC:nuclear chromosome, telomeric region);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0005876(CC:spindle microtubule);GO:0005524(MF:ATP binding);GO:0003682(MF:chromatin binding);GO:0030332(MF:cyclin binding);GO:0097472(MF:cyclin-dependent protein kinase activity);GO:0004693(MF:cyclin-dependent protein serine/threonine kinase activity);GO:0035173(MF:histone kinase activity);GO:0030544(MF:Hsp70 protein binding);GO:0004672(MF:protein kinase activity);GO:0004674(MF:protein serine/threonine kinase activity);GO:0008353(MF:RNA polymerase II carboxy-terminal domain kinase activity);GO:0001618(MF:virus receptor activity)"	hsa04540(Gap junction);hsa05170(Human immunodeficiency virus 1 infection);hsa05168(Herpes simplex infection);hsa05169(Epstein-Barr virus infection);hsa04110(Cell cycle);hsa04914(Progesterone-mediated oocyte maturation);hsa04114(Oocyte meiosis);hsa05203(Viral carcinogenesis);hsa04115(p53 signaling pathway);hsa04218(Cellular senescence)
E0CX11	0.82747	0.044769601	Short transmembrane mitochondrial protein 1	647087	STMP1	GO:0016021(CC:integral component of membrane);GO:0005746(CC:mitochondrial respiratory chain)	-
O75794	0.827437	0.01898116	Cell division cycle protein 123 homolog	8872	CDC123	GO:0007050(BP:cell cycle arrest);GO:0051301(BP:cell division);GO:1905143(BP:eukaryotic translation initiation factor 2 complex assembly);GO:0008284(BP:positive regulation of cell proliferation);GO:0045948(BP:positive regulation of translational initiation);GO:0005737(CC:cytoplasm)	-
Q9NRZ9	0.827359	0.002906382	Lymphoid-specific helicase	3070	HELLS	"GO:0007049(BP:cell cycle);GO:0051301(BP:cell division);GO:0046651(BP:lymphocyte proliferation);GO:0010216(BP:maintenance of DNA methylation);GO:0006346(BP:methylation-dependent chromatin silencing);GO:0007275(BP:multicellular organism development);GO:0031508(BP:pericentric heterochromatin assembly);GO:0000775(CC:chromosome, centromeric region);GO:0005634(CC:nucleus);GO:0005721(CC:pericentric heterochromatin);GO:0005524(MF:ATP binding);GO:0004386(MF:helicase activity)"	-
O43293	0.827319	0.001825001	Death-associated protein kinase 3	1613	DAPK3	"GO:0006915(BP:apoptotic process);GO:0097190(BP:apoptotic signaling pathway);GO:0071346(BP:cellular response to interferon-gamma);GO:0006325(BP:chromatin organization);GO:0035556(BP:intracellular signal transduction);GO:0017148(BP:negative regulation of translation);GO:0030182(BP:neuron differentiation);GO:0043065(BP:positive regulation of apoptotic process);GO:0090263(BP:positive regulation of canonical Wnt signaling pathway);GO:0030335(BP:positive regulation of cell migration);GO:2001241(BP:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand);GO:0046777(BP:protein autophosphorylation);GO:0006468(BP:protein phosphorylation);GO:2000249(BP:regulation of actin cytoskeleton reorganization);GO:0042981(BP:regulation of apoptotic process);GO:0010506(BP:regulation of autophagy);GO:2000145(BP:regulation of cell motility);GO:0008360(BP:regulation of cell shape);GO:0051893(BP:regulation of focal adhesion assembly);GO:0007346(BP:regulation of mitotic cell cycle);GO:0007088(BP:regulation of mitotic nuclear division);GO:0043519(BP:regulation of myosin II filament organization);GO:0006940(BP:regulation of smooth muscle contraction);GO:0006355(BP:regulation of transcription, DNA-templated);GO:0005884(CC:actin filament);GO:0005737(CC:cytoplasm);GO:0045121(CC:membrane raft);GO:0005634(CC:nucleus);GO:0016605(CC:PML body);GO:0005524(MF:ATP binding);GO:0008140(MF:cAMP response element binding protein binding);GO:0042802(MF:identical protein binding);GO:0043522(MF:leucine zipper domain binding);GO:0008022(MF:protein C-terminus binding);GO:0042803(MF:protein homodimerization activity);GO:0004674(MF:protein serine/threonine kinase activity);GO:0017048(MF:Rho GTPase binding)"	hsa05219(Bladder cancer);hsa04140(Autophagy - animal);hsa05200(Pathways in cancer)
P08651	0.826696	0.003999677	Nuclear factor 1 C-type	4782	NFIC	"GO:0006260(BP:DNA replication);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0042475(BP:odontogenesis of dentin-containing tooth);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0006366(BP:transcription by RNA polymerase II);GO:0001650(CC:fibrillar center);GO:0005634(CC:nucleus);GO:0001228(MF:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding);GO:0003700(MF:DNA binding transcription factor activity);GO:0000981(MF:RNA polymerase II transcription factor activity, sequence-specific DNA binding);GO:0000978(MF:RNA polymerase II proximal promoter sequence-specific DNA binding)"	-
P49643	0.82437	0.038774409	DNA primase large subunit	5558	PRIM2	"GO:0006270(BP:DNA replication initiation);GO:0006269(BP:DNA replication, synthesis of RNA primer);GO:0000082(BP:G1/S transition of mitotic cell cycle);GO:0032201(BP:telomere maintenance via semi-conservative replication);GO:0005658(CC:alpha DNA polymerase:primase complex);GO:0005654(CC:nucleoplasm);GO:0051539(MF:4 iron, 4 sulfur cluster binding);GO:0003896(MF:DNA primase activity);GO:0046872(MF:metal ion binding);GO:0003697(MF:single-stranded DNA binding)"	hsa00230(Purine metabolism);hsa03030(DNA replication);hsa00240(Pyrimidine metabolism)
P53814	0.823788	0.002530949	Smoothelin	6525	SMTN	GO:0030036(BP:actin cytoskeleton organization);GO:0007517(BP:muscle organ development);GO:0006939(BP:smooth muscle contraction);GO:0015629(CC:actin cytoskeleton);GO:0005737(CC:cytoplasm);GO:0005856(CC:cytoskeleton);GO:0031941(CC:filamentous actin);GO:0005815(CC:microtubule organizing center);GO:0003779(MF:actin binding);GO:0008307(MF:structural constituent of muscle)	-
P17050	0.823056	0.006064301	Alpha-N-acetylgalactosaminidase	4668	NAGA	GO:0016052(BP:carbohydrate catabolic process);GO:0019377(BP:glycolipid catabolic process);GO:0016139(BP:glycoside catabolic process);GO:0046477(BP:glycosylceramide catabolic process);GO:0009311(BP:oligosaccharide metabolic process);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0005764(CC:lysosome);GO:0004557(MF:alpha-galactosidase activity);GO:0008456(MF:alpha-N-acetylgalactosaminidase activity);GO:0042803(MF:protein homodimerization activity)	hsa00603(Glycosphingolipid biosynthesis - globo and isoglobo series);hsa04142(Lysosome)
Q01995	0.822202	0.000392518	Transgelin	6876	TAGLN	GO:0030855(BP:epithelial cell differentiation);GO:0007517(BP:muscle organ development);GO:0005737(CC:cytoplasm);GO:0051015(MF:actin filament binding)	-
P07951	0.821565	0.000242692	Tropomyosin beta chain	7169	TPM2	GO:0007015(BP:actin filament organization);GO:0006936(BP:muscle contraction);GO:0030049(BP:muscle filament sliding);GO:0043462(BP:regulation of ATPase activity);GO:0015629(CC:actin cytoskeleton);GO:0005884(CC:actin filament);GO:0005829(CC:cytosol);GO:0005862(CC:muscle thin filament tropomyosin);GO:0003779(MF:actin binding);GO:0051015(MF:actin filament binding);GO:0042802(MF:identical protein binding);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity);GO:0008307(MF:structural constituent of muscle)	hsa05410(Hypertrophic cardiomyopathy (HCM));hsa04260(Cardiac muscle contraction);hsa05414(Dilated cardiomyopathy (DCM));hsa04261(Adrenergic signaling in cardiomyocytes)
Q13510	0.821291	0.017733021	Acid ceramidase	427	ASAH1	"GO:0071356(BP:cellular response to tumor necrosis factor);GO:0046513(BP:ceramide biosynthetic process);GO:0046514(BP:ceramide catabolic process);GO:0006687(BP:glycosphingolipid metabolic process);GO:0030216(BP:keratinocyte differentiation);GO:1903507(BP:negative regulation of nucleic acid-templated transcription);GO:0043312(BP:neutrophil degranulation);GO:0050810(BP:regulation of steroid biosynthetic process);GO:0046512(BP:sphingosine biosynthetic process);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1904813(CC:ficolin-1-rich granule lumen);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0005634(CC:nucleus);GO:1904724(CC:tertiary granule lumen);GO:0102121(MF:ceramidase activity);GO:0016810(MF:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds);GO:0016811(MF:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides);GO:0017040(MF:N-acylsphingosine amidohydrolase activity);GO:0016922(MF:ligand-dependent nuclear receptor binding);GO:0003714(MF:transcription corepressor activity)"	hsa04142(Lysosome);hsa00600(Sphingolipid metabolism);hsa04071(Sphingolipid signaling pathway)
P51911	0.821051	0.003047484	Calponin-1	1264	CNN1	GO:0031032(BP:actomyosin structure organization);GO:1904706(BP:negative regulation of vascular smooth muscle cell proliferation);GO:0006940(BP:regulation of smooth muscle contraction);GO:0005856(CC:cytoskeleton);GO:0005925(CC:focal adhesion);GO:0003779(MF:actin binding);GO:0005516(MF:calmodulin binding)	-
Q9HAT2	0.819829	0.00194909	Sialate O-acetylesterase	54414	SIAE	GO:0005975(BP:carbohydrate metabolic process);GO:0002682(BP:regulation of immune system process);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0005764(CC:lysosome);GO:0001681(MF:sialate O-acetylesterase activity)	-
P46013	0.819334	0.028408456	Proliferation marker protein Ki-67	4288	MKI67	GO:0007049(BP:cell cycle);GO:0008283(BP:cell proliferation);GO:1902275(BP:regulation of chromatin organization);GO:0051983(BP:regulation of chromosome segregation);GO:0007088(BP:regulation of mitotic nuclear division);GO:0005694(CC:chromosome);GO:0016020(CC:membrane);GO:0016604(CC:nuclear body);GO:0005730(CC:nucleolus);GO:0005634(CC:nucleus);GO:0005524(MF:ATP binding);GO:0003677(MF:DNA binding);GO:0008022(MF:protein C-terminus binding);GO:0003723(MF:RNA binding)	-
P17936	0.819247	0.018960349	Insulin-like growth factor-binding protein 3	3486	IGFBP3	GO:0006915(BP:apoptotic process);GO:0044267(BP:cellular protein metabolic process);GO:0008285(BP:negative regulation of cell proliferation);GO:0001933(BP:negative regulation of protein phosphorylation);GO:0009968(BP:negative regulation of signal transduction);GO:0014912(BP:negative regulation of smooth muscle cell migration);GO:0048662(BP:negative regulation of smooth muscle cell proliferation);GO:0001649(BP:osteoblast differentiation);GO:0043065(BP:positive regulation of apoptotic process);GO:0043568(BP:positive regulation of insulin-like growth factor receptor signaling pathway);GO:0043410(BP:positive regulation of MAPK cascade);GO:0045663(BP:positive regulation of myoblast differentiation);GO:0043687(BP:post-translational protein modification);GO:0006468(BP:protein phosphorylation);GO:0042981(BP:regulation of apoptotic process);GO:0001558(BP:regulation of cell growth);GO:0010906(BP:regulation of glucose metabolic process);GO:0043567(BP:regulation of insulin-like growth factor receptor signaling pathway);GO:0044342(BP:type B pancreatic cell proliferation);GO:0005788(CC:endoplasmic reticulum lumen);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0016942(CC:insulin-like growth factor binding protein complex);GO:0042567(CC:insulin-like growth factor ternary complex);GO:0005634(CC:nucleus);GO:0001968(MF:fibronectin binding);GO:0005520(MF:insulin-like growth factor binding);GO:0031994(MF:insulin-like growth factor I binding);GO:0031995(MF:insulin-like growth factor II binding);GO:0046872(MF:metal ion binding);GO:0008160(MF:protein tyrosine phosphatase activator activity)	hsa04115(p53 signaling pathway);hsa05202(Transcriptional misregulation in cancer);hsa04218(Cellular senescence)
P61916	0.81894	0.006169654	NPC intracellular cholesterol transporter 2	10577	NPC2	GO:0033344(BP:cholesterol efflux);GO:0042632(BP:cholesterol homeostasis);GO:0008203(BP:cholesterol metabolic process);GO:0030301(BP:cholesterol transport);GO:0046836(BP:glycolipid transport);GO:0032367(BP:intracellular cholesterol transport);GO:0032366(BP:intracellular sterol transport);GO:0034383(BP:low-density lipoprotein particle clearance);GO:0043312(BP:neutrophil degranulation);GO:0015914(BP:phospholipid transport);GO:0019747(BP:regulation of isoprenoid metabolic process);GO:0009615(BP:response to virus);GO:0035578(CC:azurophil granule lumen);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0015485(MF:cholesterol binding);GO:0017127(MF:cholesterol transporter activity);GO:0019899(MF:enzyme binding)	hsa04979(Cholesterol metabolism);hsa04142(Lysosome)
Q9BSY4	0.818598	0.035942295	Coiled-coil-helix-coiled-coil-helix domain-containing protein 5	84269	CHCHD5	GO:0005758(CC:mitochondrial intermembrane space)	-
Q15022	0.815115	0.003290254	Polycomb protein SUZ12	23512	SUZ12	"GO:0070734(BP:histone H3-K27 methylation);GO:0016574(BP:histone ubiquitination);GO:0045596(BP:negative regulation of cell differentiation);GO:0070317(BP:negative regulation of G0 to G1 transition);GO:0045814(BP:negative regulation of gene expression, epigenetic);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0008284(BP:positive regulation of cell proliferation);GO:0035098(CC:ESC/E(Z) complex);GO:0016604(CC:nuclear body);GO:0005730(CC:nucleolus);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0032993(CC:protein-DNA complex);GO:0016586(CC:RSC-type complex);GO:0001739(CC:sex chromatin);GO:0031490(MF:chromatin DNA binding);GO:0042054(MF:histone methyltransferase activity);GO:0046872(MF:metal ion binding);GO:0035064(MF:methylated histone binding);GO:1990841(MF:promoter-specific chromatin binding);GO:0003723(MF:RNA binding);GO:0000978(MF:RNA polymerase II proximal promoter sequence-specific DNA binding)"	-
Q9BQI0	0.814252	0.00138381	Allograft inflammatory factor 1-like	83543	AIF1L	GO:0051017(BP:actin filament bundle assembly);GO:0097178(BP:ruffle assembly);GO:0015629(CC:actin cytoskeleton);GO:0042995(CC:cell projection);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0005925(CC:focal adhesion);GO:0032991(CC:protein-containing complex);GO:0032587(CC:ruffle membrane);GO:0051015(MF:actin filament binding);GO:0005509(MF:calcium ion binding)	-
Q9NWK9	0.81413	0.046873002	Box C/D snoRNA protein 1	54680	ZNHIT6	"GO:0000492(BP:box C/D snoRNP assembly);GO:0000463(BP:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA));GO:0051259(BP:protein complex oligomerization);GO:0048254(BP:snoRNA localization);GO:0070062(CC:extracellular exosome);GO:0005634(CC:nucleus);GO:0070761(CC:pre-snoRNP complex);GO:0051117(MF:ATPase binding);GO:0019899(MF:enzyme binding);GO:0042802(MF:identical protein binding);GO:0046872(MF:metal ion binding);GO:0001094(MF:TFIID-class transcription factor binding)"	-
Q9HBM1	0.813394	0.024561738	Kinetochore protein Spc25	57405	SPC25	GO:0051301(BP:cell division);GO:0007059(BP:chromosome segregation);GO:0007052(BP:mitotic spindle organization);GO:0000777(CC:condensed chromosome kinetochore);GO:0005829(CC:cytosol);GO:0031262(CC:Ndc80 complex);GO:0005634(CC:nucleus)	-
P06280	0.811713	0.031708273	Alpha-galactosidase A	2717	GLA	GO:0016139(BP:glycoside catabolic process);GO:0046479(BP:glycosphingolipid catabolic process);GO:0006687(BP:glycosphingolipid metabolic process);GO:0046477(BP:glycosylceramide catabolic process);GO:0045019(BP:negative regulation of nitric oxide biosynthetic process);GO:0051001(BP:negative regulation of nitric-oxide synthase activity);GO:0043312(BP:neutrophil degranulation);GO:0009311(BP:oligosaccharide metabolic process);GO:0035578(CC:azurophil granule lumen);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005794(CC:Golgi apparatus);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0004557(MF:alpha-galactosidase activity);GO:0003824(MF:catalytic activity);GO:0016936(MF:galactoside binding);GO:0016787(MF:hydrolase activity);GO:0042803(MF:protein homodimerization activity);GO:0052692(MF:raffinose alpha-galactosidase activity);GO:0005102(MF:signaling receptor binding)	hsa00603(Glycosphingolipid biosynthesis - globo and isoglobo series);hsa00052(Galactose metabolism);hsa00600(Sphingolipid metabolism);hsa04142(Lysosome);hsa00561(Glycerolipid metabolism)
P21333	0.810704	0.000519008	Filamin-A	2316	FLNA	"GO:0051764(BP:actin crosslink formation);GO:0031532(BP:actin cytoskeleton reorganization);GO:0007195(BP:adenylate cyclase-inhibiting dopamine receptor signaling pathway);GO:0034329(BP:cell junction assembly);GO:0021987(BP:cerebral cortex development);GO:0060271(BP:cilium assembly);GO:0051220(BP:cytoplasmic sequestering of protein);GO:0051607(BP:defense response to virus);GO:0045184(BP:establishment of protein localization);GO:0097368(BP:establishment of Sertoli cell barrier);GO:0021943(BP:formation of radial glial scaffolds);GO:0090307(BP:mitotic spindle assembly);GO:0042789(BP:mRNA transcription by RNA polymerase II);GO:0043066(BP:negative regulation of apoptotic process);GO:0043433(BP:negative regulation of DNA binding transcription factor activity);GO:0042177(BP:negative regulation of protein catabolic process);GO:0016479(BP:negative regulation of transcription by RNA polymerase I);GO:0030168(BP:platelet activation);GO:0070527(BP:platelet aggregation);GO:0002576(BP:platelet degranulation);GO:0032233(BP:positive regulation of actin filament bundle assembly);GO:0043123(BP:positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:2001046(BP:positive regulation of integrin-mediated signaling pathway);GO:2000179(BP:positive regulation of neural precursor cell proliferation);GO:2001224(BP:positive regulation of neuron migration);GO:1901381(BP:positive regulation of potassium ion transmembrane transport);GO:0042307(BP:positive regulation of protein import into nucleus);GO:1900026(BP:positive regulation of substrate adhesion-dependent cell spreading);GO:1902396(BP:protein localization to bicellular tight junction);GO:0034394(BP:protein localization to cell surface);GO:0072659(BP:protein localization to plasma membrane);GO:0050821(BP:protein stabilization);GO:0043113(BP:receptor clustering);GO:0030334(BP:regulation of cell migration);GO:1905000(BP:regulation of membrane repolarization during atrial cardiac muscle cell action potential);GO:1905031(BP:regulation of membrane repolarization during cardiac muscle cell action potential);GO:0071526(BP:semaphorin-plexin signaling pathway);GO:0044319(BP:wound healing, spreading of cells);GO:0015629(CC:actin cytoskeleton);GO:0005884(CC:actin filament);GO:0097440(CC:apical dendrite);GO:0005911(CC:cell-cell junction);GO:0030863(CC:cortical cytoskeleton);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0043198(CC:dendritic shaft);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005925(CC:focal adhesion);GO:0098978(CC:glutamatergic synapse);GO:0016020(CC:membrane);GO:0031523(CC:Myb complex);GO:0043025(CC:neuronal cell body);GO:0005730(CC:nucleolus);GO:0005634(CC:nucleus);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005886(CC:plasma membrane);GO:0098794(CC:postsynapse);GO:0030018(CC:Z disc);GO:0051015(MF:actin filament binding);GO:0045296(MF:cadherin binding);GO:0034988(MF:Fc-gamma receptor I complex binding);GO:0001664(MF:G-protein coupled receptor binding);GO:0051020(MF:GTPase binding);GO:0044325(MF:ion channel binding);GO:0019900(MF:kinase binding);GO:0031852(MF:mu-type opioid receptor binding);GO:0015459(MF:potassium channel regulator activity);GO:0042803(MF:protein homodimerization activity);GO:0048365(MF:Rac GTPase binding);GO:0017160(MF:Ral GTPase binding);GO:0017048(MF:Rho GTPase binding);GO:0003723(MF:RNA binding);GO:0046332(MF:SMAD binding);GO:0031267(MF:small GTPase binding);GO:0008134(MF:transcription factor binding)"	hsa04010(MAPK signaling pathway);hsa04510(Focal adhesion);hsa05132(Salmonella infection);hsa05205(Proteoglycans in cancer)
Q96KB5	0.810622	0.00952838	Lymphokine-activated killer T-cell-originated protein kinase	55872	PBK	GO:0034644(BP:cellular response to UV);GO:0000278(BP:mitotic cell cycle);GO:0050728(BP:negative regulation of inflammatory response);GO:0032435(BP:negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032873(BP:negative regulation of stress-activated MAPK cascade);GO:0005634(CC:nucleus);GO:0005524(MF:ATP binding);GO:0004674(MF:protein serine/threonine kinase activity)	-
A6ZKI3	0.810486	0.018418064	Retrotransposon Gag-like protein 8B	8933	RTL8C	-	-
Q6ULP2	0.808669	0.001867169	Aftiphilin	54812	AFTPH	GO:0046907(BP:intracellular transport);GO:0030121(CC:AP-1 adaptor complex);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005794(CC:Golgi apparatus);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005634(CC:nucleus);GO:0032588(CC:trans-Golgi network membrane);GO:0030276(MF:clathrin binding);GO:0008565(MF:protein transporter activity)	-
Q92820	0.808137	0.001699936	Gamma-glutamyl hydrolase	8836	GGH	GO:0043312(BP:neutrophil degranulation);GO:0045471(BP:response to ethanol);GO:0032868(BP:response to insulin);GO:0010043(BP:response to zinc ion);GO:0046900(BP:tetrahydrofolylpolyglutamate metabolic process);GO:0035578(CC:azurophil granule lumen);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0042470(CC:melanosome);GO:0005634(CC:nucleus);GO:0035580(CC:specific granule lumen);GO:1904724(CC:tertiary granule lumen);GO:0005773(CC:vacuole);GO:0008238(MF:exopeptidase activity);GO:0034722(MF:gamma-glutamyl-peptidase activity);GO:0008242(MF:omega peptidase activity)	hsa01523(Antifolate resistance);hsa00790(Folate biosynthesis)
Q9UNS1	0.802038	0.033402931	Protein timeless homolog	8914	TIMELESS	"GO:0048754(BP:branching morphogenesis of an epithelial tube);GO:0044770(BP:cell cycle phase transition);GO:0051301(BP:cell division);GO:1904976(BP:cellular response to bleomycin);GO:0072719(BP:cellular response to cisplatin);GO:0006974(BP:cellular response to DNA damage stimulus);GO:0072711(BP:cellular response to hydroxyurea);GO:0007623(BP:circadian rhythm);GO:0009582(BP:detection of abiotic stimulus);GO:0006281(BP:DNA repair);GO:0006260(BP:DNA replication);GO:0000076(BP:DNA replication checkpoint);GO:0030324(BP:lung development);GO:0002009(BP:morphogenesis of an epithelium);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0045892(BP:negative regulation of transcription, DNA-templated);GO:2000781(BP:positive regulation of double-strand break repair);GO:1905168(BP:positive regulation of double-strand break repair via homologous recombination);GO:0042752(BP:regulation of circadian rhythm);GO:0043111(BP:replication fork arrest);GO:0048478(BP:replication fork protection);GO:0000790(CC:nuclear chromatin);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0031298(CC:replication fork protection complex);GO:0035861(CC:site of double-strand break);GO:0003677(MF:DNA binding);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity)"	-
P04066	0.800001	0.008349069	Tissue alpha-L-fucosidase	2517	FUCA1	GO:0006004(BP:fucose metabolic process);GO:0019377(BP:glycolipid catabolic process);GO:0006027(BP:glycosaminoglycan catabolic process);GO:0016139(BP:glycoside catabolic process);GO:0043312(BP:neutrophil degranulation);GO:0035578(CC:azurophil granule lumen);GO:0005737(CC:cytoplasm);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0004560(MF:alpha-L-fucosidase activity)	hsa00511(Other glycan degradation);hsa04142(Lysosome)
P07339	0.799776	0.000189602	Cathepsin D	1509	CTSD	GO:0019886(BP:antigen processing and presentation of exogenous peptide antigen via MHC class II);GO:0030574(BP:collagen catabolic process);GO:0042159(BP:lipoprotein catabolic process);GO:0043312(BP:neutrophil degranulation);GO:0043065(BP:positive regulation of apoptotic process);GO:0043280(BP:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0030163(BP:protein catabolic process);GO:0006508(BP:proteolysis);GO:0070201(BP:regulation of establishment of protein localization);GO:0010008(CC:endosome membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1904813(CC:ficolin-1-rich granule lumen);GO:0043202(CC:lysosomal lumen);GO:0005765(CC:lysosomal membrane);GO:0005764(CC:lysosome);GO:0042470(CC:melanosome);GO:0045121(CC:membrane raft);GO:0035580(CC:specific granule lumen);GO:1904724(CC:tertiary granule lumen);GO:0004190(MF:aspartic-type endopeptidase activity);GO:0070001(MF:aspartic-type peptidase activity);GO:0008233(MF:peptidase activity)	hsa04071(Sphingolipid signaling pathway);hsa05152(Tuberculosis);hsa04915(Estrogen signaling pathway);hsa04140(Autophagy - animal);hsa04142(Lysosome);hsa04210(Apoptosis)
Q99622	0.79858	0.00036532	Protein C10	113246	C12orf57	GO:0048593(BP:camera-type eye morphogenesis);GO:0050890(BP:cognition);GO:0021540(BP:corpus callosum morphogenesis);GO:0009791(BP:post-embryonic development);GO:0036343(BP:psychomotor behavior);GO:0014819(BP:regulation of skeletal muscle contraction);GO:0021678(BP:third ventricle development);GO:0005737(CC:cytoplasm);GO:0016607(CC:nuclear speck)	-
Q15646	0.797923	0.019441368	2'-5'-oligoadenylate synthase-like protein	8638	OASL	GO:0051607(BP:defense response to virus);GO:0060333(BP:interferon-gamma-mediated signaling pathway);GO:0045071(BP:negative regulation of viral genome replication);GO:0060700(BP:regulation of ribonuclease activity);GO:0009615(BP:response to virus);GO:0060337(BP:type I interferon signaling pathway);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0016020(CC:membrane);GO:0005730(CC:nucleolus);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0005524(MF:ATP binding);GO:0003677(MF:DNA binding);GO:0003725(MF:double-stranded RNA binding);GO:0003723(MF:RNA binding);GO:0046966(MF:thyroid hormone receptor binding);GO:0016740(MF:transferase activity)	hsa05165(Human papillomavirus infection)
P61812	0.796341	0.002226848	Transforming growth factor beta-2 proprotein	7042	TGFB2	GO:0032147(BP:activation of protein kinase activity);GO:0001525(BP:angiogenesis);GO:0035910(BP:ascending aorta morphogenesis);GO:0060413(BP:atrial septum morphogenesis);GO:0003289(BP:atrial septum primum morphogenesis);GO:0003181(BP:atrioventricular valve morphogenesis);GO:0060317(BP:cardiac epithelial to mesenchymal transition);GO:0060038(BP:cardiac muscle cell proliferation);GO:0003215(BP:cardiac right ventricle morphogenesis);GO:0010002(BP:cardioblast differentiation);GO:0007050(BP:cell cycle arrest);GO:0008219(BP:cell death);GO:0048468(BP:cell development);GO:0016477(BP:cell migration);GO:0000902(BP:cell morphogenesis);GO:0008283(BP:cell proliferation);GO:0045216(BP:cell-cell junction organization);GO:0007267(BP:cell-cell signaling);GO:0030199(BP:collagen fibril organization);GO:1904888(BP:cranial skeletal system development);GO:0042416(BP:dopamine biosynthetic process);GO:0009792(BP:embryo development ending in birth or egg hatching);GO:0048566(BP:embryonic digestive tract development);GO:0030326(BP:embryonic limb morphogenesis);GO:0003274(BP:endocardial cushion fusion);GO:0003203(BP:endocardial cushion morphogenesis);GO:0001837(BP:epithelial to mesenchymal transition);GO:0097191(BP:extrinsic apoptotic signaling pathway);GO:0001654(BP:eye development);GO:0048699(BP:generation of neurons);GO:0008347(BP:glial cell migration);GO:0001942(BP:hair follicle development);GO:0031069(BP:hair follicle morphogenesis);GO:0007507(BP:heart development);GO:0003007(BP:heart morphogenesis);GO:0003179(BP:heart valve morphogenesis);GO:0030097(BP:hemopoiesis);GO:0048839(BP:inner ear development);GO:0001822(BP:kidney development);GO:0008584(BP:male gonad development);GO:0003149(BP:membranous septum morphogenesis);GO:0010693(BP:negative regulation of alkaline phosphatase activity);GO:0016525(BP:negative regulation of angiogenesis);GO:0030308(BP:negative regulation of cell growth);GO:0008285(BP:negative regulation of cell proliferation);GO:0050680(BP:negative regulation of epithelial cell proliferation);GO:1905006(BP:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation);GO:0010629(BP:negative regulation of gene expression);GO:0050777(BP:negative regulation of immune response);GO:0010936(BP:negative regulation of macrophage cytokine production);GO:0046580(BP:negative regulation of Ras protein signal transduction);GO:0003407(BP:neural retina development);GO:0001843(BP:neural tube closure);GO:0048666(BP:neuron development);GO:0030593(BP:neutrophil chemotaxis);GO:0042476(BP:odontogenesis);GO:0003148(BP:outflow tract septum morphogenesis);GO:0060389(BP:pathway-restricted SMAD protein phosphorylation);GO:0061626(BP:pharyngeal arch artery morphogenesis);GO:0002576(BP:platelet degranulation);GO:0051891(BP:positive regulation of cardioblast differentiation);GO:0033630(BP:positive regulation of cell adhesion mediated by integrin);GO:0045787(BP:positive regulation of cell cycle);GO:0051781(BP:positive regulation of cell division);GO:0030307(BP:positive regulation of cell growth);GO:0008284(BP:positive regulation of cell proliferation);GO:0010634(BP:positive regulation of epithelial cell migration);GO:0010718(BP:positive regulation of epithelial to mesenchymal transition);GO:1905007(BP:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation);GO:0045823(BP:positive regulation of heart contraction);GO:0050778(BP:positive regulation of immune response);GO:0045726(BP:positive regulation of integrin biosynthetic process);GO:0043525(BP:positive regulation of neuron apoptotic process);GO:0045747(BP:positive regulation of Notch signaling pathway);GO:0045778(BP:positive regulation of ossification);GO:0010862(BP:positive regulation of pathway-restricted SMAD protein phosphorylation);GO:0014068(BP:positive regulation of phosphatidylinositol 3-kinase signaling);GO:1902895(BP:positive regulation of pri-miRNA transcription by RNA polymerase II);GO:0050714(BP:positive regulation of protein secretion);GO:0032874(BP:positive regulation of stress-activated MAPK cascade);GO:0051795(BP:positive regulation of timing of catagen);GO:0006468(BP:protein phosphorylation);GO:0003184(BP:pulmonary valve morphogenesis);GO:0042981(BP:regulation of apoptotic process);GO:1902256(BP:regulation of apoptotic process involved in outflow tract morphogenesis);GO:0042127(BP:regulation of cell proliferation);GO:0043408(BP:regulation of MAPK cascade);GO:0051794(BP:regulation of timing of catagen);GO:0032909(BP:regulation of transforming growth factor beta2 production);GO:0042493(BP:response to drug);GO:0001666(BP:response to hypoxia);GO:0032570(BP:response to progesterone);GO:0009611(BP:response to wounding);GO:0007435(BP:salivary gland morphogenesis);GO:0062009(BP:secondary palate development);GO:0001501(BP:skeletal system development);GO:0060395(BP:SMAD protein signal transduction);GO:0048103(BP:somatic stem cell division);GO:1903701(BP:substantia propria of cornea development);GO:0007179(BP:transforming growth factor beta receptor signaling pathway);GO:0042704(BP:uterine wall breakdown);GO:0060065(BP:uterus development);GO:0060412(BP:ventricular septum morphogenesis);GO:0003222(BP:ventricular trabecula myocardium morphogenesis);GO:0042060(BP:wound healing);GO:0030424(CC:axon);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0043025(CC:neuronal cell body);GO:0031093(CC:platelet alpha granule lumen);GO:0001540(MF:amyloid-beta binding);GO:0005125(MF:cytokine activity);GO:0008083(MF:growth factor activity);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity);GO:0005102(MF:signaling receptor binding);GO:0005160(MF:transforming growth factor beta receptor binding);GO:0005114(MF:type II transforming growth factor beta receptor binding);GO:0034714(MF:type III transforming growth factor beta receptor binding)	hsa05220(Chronic myeloid leukemia);hsa05145(Toxoplasmosis);hsa05205(Proteoglycans in cancer);hsa04350(TGF-beta signaling pathway);hsa05142(Chagas disease (American trypanosomiasis));hsa05226(Gastric cancer);hsa04933(AGE-RAGE signaling pathway in diabetic complications);hsa05323(Rheumatoid arthritis);hsa05152(Tuberculosis);hsa05321(Inflammatory bowel disease (IBD));hsa05206(MicroRNAs in cancer);hsa05225(Hepatocellular carcinoma);hsa05200(Pathways in cancer);hsa05210(Colorectal cancer);hsa05414(Dilated cardiomyopathy (DCM));hsa04068(FoxO signaling pathway);hsa05410(Hypertrophic cardiomyopathy (HCM));hsa05161(Hepatitis B);hsa04218(Cellular senescence);hsa05211(Renal cell carcinoma);hsa05140(Leishmaniasis);hsa05166(Human T-cell leukemia virus 1 infection);hsa04380(Osteoclast differentiation);hsa05146(Amoebiasis);hsa04060(Cytokine-cytokine receptor interaction);hsa04010(MAPK signaling pathway);hsa04110(Cell cycle);hsa05144(Malaria);hsa05212(Pancreatic cancer);hsa04390(Hippo signaling pathway)
Q9UDY4	0.795536	0.001020477	DnaJ homolog subfamily B member 4	11080	DNAJB4	GO:0051085(BP:chaperone cofactor-dependent protein refolding);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0009408(BP:response to heat);GO:0006986(BP:response to unfolded protein);GO:0005829(CC:cytosol);GO:0005654(CC:nucleoplasm);GO:0005886(CC:plasma membrane);GO:0001671(MF:ATPase activator activity);GO:0051087(MF:chaperone binding);GO:0051082(MF:unfolded protein binding)	-
Q9BZX2	0.793366	0.001670309	Uridine-cytidine kinase 2	7371	UCK2	GO:0006238(BP:CMP salvage);GO:0044211(BP:CTP salvage);GO:0043097(BP:pyrimidine nucleoside salvage);GO:0044206(BP:UMP salvage);GO:0005829(CC:cytosol);GO:0005524(MF:ATP binding);GO:0042802(MF:identical protein binding);GO:0016301(MF:kinase activity);GO:0019206(MF:nucleoside kinase activity);GO:0004849(MF:uridine kinase activity)	hsa00240(Pyrimidine metabolism);hsa00983(Drug metabolism - other enzymes)
Q9NQW6	0.792779	0.005522483	Anillin	54443	ANLN	GO:0000915(BP:actomyosin contractile ring assembly);GO:0030865(BP:cortical cytoskeleton organization);GO:0090521(BP:glomerular visceral epithelial cell migration);GO:0002244(BP:hematopoietic progenitor cell differentiation);GO:0000281(BP:mitotic cytokinesis);GO:1904172(BP:positive regulation of bleb assembly);GO:1904498(BP:protein localization to mitotic actomyosin contractile ring);GO:0007096(BP:regulation of exit from mitosis);GO:0000921(BP:septin ring assembly);GO:0031106(BP:septin ring organization);GO:0015629(CC:actin cytoskeleton);GO:0005826(CC:actomyosin contractile ring);GO:0032059(CC:bleb);GO:0099738(CC:cell cortex region);GO:0030496(CC:midbody);GO:0005654(CC:nucleoplasm);GO:0003779(MF:actin binding);GO:0045296(MF:cadherin binding);GO:0017049(MF:GTP-Rho binding)	-
P14209	0.790766	0.049547136	CD99 antigen	4267	CD99	GO:0007155(BP:cell adhesion);GO:0050776(BP:regulation of immune response);GO:0005737(CC:cytoplasm);GO:0005925(CC:focal adhesion);GO:0005887(CC:integral component of plasma membrane);GO:0005886(CC:plasma membrane)	hsa04670(Leukocyte transendothelial migration);hsa04514(Cell adhesion molecules (CAMs))
Q9UH17	0.780943	0.014116659	DNA dC->dU-editing enzyme APOBEC-3B	9582	APOBEC3B	GO:0016554(BP:cytidine to uridine editing);GO:0051607(BP:defense response to virus);GO:0080111(BP:DNA demethylation);GO:0045087(BP:innate immune response);GO:0010529(BP:negative regulation of transposition);GO:0005737(CC:cytoplasm);GO:0005634(CC:nucleus);GO:0004126(MF:cytidine deaminase activity);GO:0047844(MF:deoxycytidine deaminase activity);GO:0003723(MF:RNA binding);GO:0008270(MF:zinc ion binding)	hsa05170(Human immunodeficiency virus 1 infection)
P50897	0.768076	0.002284074	Palmitoyl-protein thioesterase 1	5538	PPT1	GO:0008344(BP:adult locomotory behavior);GO:0008306(BP:associative learning);GO:0007420(BP:brain development);GO:0044257(BP:cellular protein catabolic process);GO:0051186(BP:cofactor metabolic process);GO:0051181(BP:cofactor transport);GO:0046949(BP:fatty-acyl-CoA biosynthetic process);GO:0007625(BP:grooming behavior);GO:0016042(BP:lipid catabolic process);GO:0007042(BP:lysosomal lumen acidification);GO:0031579(BP:membrane raft organization);GO:0043066(BP:negative regulation of apoptotic process);GO:0030308(BP:negative regulation of cell growth);GO:0043524(BP:negative regulation of neuron apoptotic process);GO:0007399(BP:nervous system development);GO:0048666(BP:neuron development);GO:0007269(BP:neurotransmitter secretion);GO:0006907(BP:pinocytosis);GO:0048549(BP:positive regulation of pinocytosis);GO:0048260(BP:positive regulation of receptor-mediated endocytosis);GO:0030163(BP:protein catabolic process);GO:0002084(BP:protein depalmitoylation);GO:0015031(BP:protein transport);GO:0006898(BP:receptor-mediated endocytosis);GO:0032429(BP:regulation of phospholipase A2 activity);GO:0050803(BP:regulation of synapse structure or activity);GO:0050896(BP:response to stimulus);GO:0030149(BP:sphingolipid catabolic process);GO:0007601(BP:visual perception);GO:0030424(CC:axon);GO:0005829(CC:cytosol);GO:0030425(CC:dendrite);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005794(CC:Golgi apparatus);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0016020(CC:membrane);GO:0045121(CC:membrane raft);GO:0043025(CC:neuronal cell body);GO:0005634(CC:nucleus);GO:0008021(CC:synaptic vesicle);GO:0008474(MF:palmitoyl-(protein) hydrolase activity);GO:0016290(MF:palmitoyl-CoA hydrolase activity)	hsa04142(Lysosome);hsa00062(Fatty acid elongation)
O00462	0.766328	0.002356893	Beta-mannosidase	4126	MANBA	GO:0006464(BP:cellular protein modification process);GO:0006516(BP:glycoprotein catabolic process);GO:0046355(BP:mannan catabolic process);GO:0043312(BP:neutrophil degranulation);GO:0009313(BP:oligosaccharide catabolic process);GO:0035577(CC:azurophil granule membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0005886(CC:plasma membrane);GO:0004567(MF:beta-mannosidase activity);GO:0005537(MF:mannose binding)	hsa04142(Lysosome);hsa00511(Other glycan degradation)
Q86TG7	0.766211	0.003644819	Retrotransposon-derived protein PEG10	23089	PEG10	GO:0006915(BP:apoptotic process);GO:0030154(BP:cell differentiation);GO:0030512(BP:negative regulation of transforming growth factor beta receptor signaling pathway);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005634(CC:nucleus);GO:0003677(MF:DNA binding);GO:0003723(MF:RNA binding);GO:0008270(MF:zinc ion binding)	-
P17405	0.765553	0.007207144	Sphingomyelin phosphodiesterase	6609	SMPD1	"GO:0046513(BP:ceramide biosynthetic process);GO:0008203(BP:cholesterol metabolic process);GO:0006687(BP:glycosphingolipid metabolic process);GO:0043407(BP:negative regulation of MAP kinase activity);GO:0007399(BP:nervous system development);GO:0043065(BP:positive regulation of apoptotic process);GO:0035307(BP:positive regulation of protein dephosphorylation);GO:0042220(BP:response to cocaine);GO:0007165(BP:signal transduction);GO:0006685(BP:sphingomyelin catabolic process);GO:0006684(BP:sphingomyelin metabolic process);GO:0023021(BP:termination of signal transduction);GO:0005768(CC:endosome);GO:0070062(CC:extracellular exosome);GO:0005615(CC:extracellular space);GO:0042599(CC:lamellar body);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0005886(CC:plasma membrane);GO:0061750(MF:acid sphingomyelin phosphodiesterase activity);GO:0016798(MF:hydrolase activity, acting on glycosyl bonds);GO:0008081(MF:phosphoric diester hydrolase activity);GO:0004767(MF:sphingomyelin phosphodiesterase activity);GO:0008270(MF:zinc ion binding)"	hsa04142(Lysosome);hsa00600(Sphingolipid metabolism);hsa04071(Sphingolipid signaling pathway);hsa04217(Necroptosis)
P17342	0.760455	0.007481957	Atrial natriuretic peptide receptor 3	4883	NPR3	GO:0007193(BP:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007194(BP:negative regulation of adenylate cyclase activity);GO:0048662(BP:negative regulation of smooth muscle cell proliferation);GO:0002158(BP:osteoclast proliferation);GO:0030157(BP:pancreatic juice secretion);GO:0048015(BP:phosphatidylinositol-mediated signaling);GO:0007200(BP:phospholipase C-activating G-protein coupled receptor signaling pathway);GO:0051000(BP:positive regulation of nitric-oxide synthase activity);GO:0035810(BP:positive regulation of urine volume);GO:0008217(BP:regulation of blood pressure);GO:0033688(BP:regulation of osteoblast proliferation);GO:0001501(BP:skeletal system development);GO:0070062(CC:extracellular exosome);GO:0005887(CC:integral component of plasma membrane);GO:0032991(CC:protein-containing complex);GO:0031404(MF:chloride ion binding);GO:0008528(MF:G-protein coupled peptide receptor activity);GO:0042562(MF:hormone binding);GO:0016941(MF:natriuretic peptide receptor activity);GO:0042277(MF:peptide binding);GO:0017046(MF:peptide hormone binding);GO:0042803(MF:protein homodimerization activity)	-
O75369	0.755575	0.000433658	Filamin-B	2317	FLNB	GO:0030036(BP:actin cytoskeleton organization);GO:0071346(BP:cellular response to interferon-gamma);GO:0007016(BP:cytoskeletal anchoring at plasma membrane);GO:0003382(BP:epithelial cell morphogenesis);GO:0003334(BP:keratinocyte development);GO:0007165(BP:signal transduction);GO:0007519(BP:skeletal muscle tissue development);GO:0015629(CC:actin cytoskeleton);GO:0005903(CC:brush border);GO:0005938(CC:cell cortex);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0005925(CC:focal adhesion);GO:0016021(CC:integral component of membrane);GO:0043005(CC:neuron projection);GO:0043025(CC:neuronal cell body);GO:0005634(CC:nucleus);GO:0045335(CC:phagocytic vesicle);GO:0005886(CC:plasma membrane);GO:0001725(CC:stress fiber);GO:0030018(CC:Z disc);GO:0003779(MF:actin binding);GO:0045296(MF:cadherin binding);GO:0042802(MF:identical protein binding);GO:0003723(MF:RNA binding)	hsa05205(Proteoglycans in cancer);hsa04010(MAPK signaling pathway);hsa04510(Focal adhesion);hsa05132(Salmonella infection)
P09493	0.751756	0.000214689	Tropomyosin alpha-1 chain	7168	TPM1	GO:0007015(BP:actin filament organization);GO:0060048(BP:cardiac muscle contraction);GO:0034614(BP:cellular response to reactive oxygen species);GO:0007010(BP:cytoskeleton organization);GO:0001701(BP:in utero embryonic development);GO:0006936(BP:muscle contraction);GO:0030049(BP:muscle filament sliding);GO:0030336(BP:negative regulation of cell migration);GO:1904753(BP:negative regulation of vascular associated smooth muscle cell migration);GO:1904706(BP:negative regulation of vascular smooth muscle cell proliferation);GO:0032781(BP:positive regulation of ATPase activity);GO:0045785(BP:positive regulation of cell adhesion);GO:0003065(BP:positive regulation of heart rate by epinephrine);GO:0051496(BP:positive regulation of stress fiber assembly);GO:0008360(BP:regulation of cell shape);GO:0008016(BP:regulation of heart contraction);GO:0006937(BP:regulation of muscle contraction);GO:0031529(BP:ruffle organization);GO:0045214(BP:sarcomere organization);GO:0055010(BP:ventricular cardiac muscle tissue morphogenesis);GO:0042060(BP:wound healing);GO:0015629(CC:actin cytoskeleton);GO:0005884(CC:actin filament);GO:0032059(CC:bleb);GO:0005856(CC:cytoskeleton);GO:0005829(CC:cytosol);GO:0005862(CC:muscle thin filament tropomyosin);GO:0032587(CC:ruffle membrane);GO:0030017(CC:sarcomere);GO:0001725(CC:stress fiber);GO:0003779(MF:actin binding);GO:0051015(MF:actin filament binding);GO:0008092(MF:cytoskeletal protein binding);GO:0042802(MF:identical protein binding);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity);GO:0005200(MF:structural constituent of cytoskeleton);GO:0008307(MF:structural constituent of muscle)	hsa05410(Hypertrophic cardiomyopathy (HCM));hsa05206(MicroRNAs in cancer);hsa04261(Adrenergic signaling in cardiomyocytes);hsa04260(Cardiac muscle contraction);hsa05414(Dilated cardiomyopathy (DCM))
P53634	0.751132	0.014104757	Dipeptidyl peptidase 1	1075	CTSC	GO:0007568(BP:aging);GO:0048208(BP:COPII vesicle coating);GO:0006888(BP:ER to Golgi vesicle-mediated transport);GO:0006955(BP:immune response);GO:0031642(BP:negative regulation of myelination);GO:0043312(BP:neutrophil degranulation);GO:2001235(BP:positive regulation of apoptotic signaling pathway);GO:1903980(BP:positive regulation of microglial cell activation);GO:1903052(BP:positive regulation of proteolysis involved in cellular protein catabolic process);GO:0006508(BP:proteolysis);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:0010033(BP:response to organic substance);GO:0001913(BP:T cell mediated cytotoxicity);GO:0035578(CC:azurophil granule lumen);GO:0005813(CC:centrosome);GO:0030134(CC:COPII-coated ER to Golgi transport vesicle);GO:0005788(CC:endoplasmic reticulum lumen);GO:0033116(CC:endoplasmic reticulum-Golgi intermediate compartment membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0000139(CC:Golgi membrane);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005764(CC:lysosome);GO:0016020(CC:membrane);GO:0005654(CC:nucleoplasm);GO:0051087(MF:chaperone binding);GO:0031404(MF:chloride ion binding);GO:0004197(MF:cysteine-type endopeptidase activity);GO:0008234(MF:cysteine-type peptidase activity);GO:0042802(MF:identical protein binding);GO:0016505(MF:peptidase activator activity involved in apoptotic process);GO:0019902(MF:phosphatase binding);GO:0043621(MF:protein self-association);GO:0004252(MF:serine-type endopeptidase activity)	hsa04210(Apoptosis);hsa04142(Lysosome)
Q14691	0.744626	0.04983869	DNA replication complex GINS protein PSF1	9837	GINS1	GO:0006271(BP:DNA strand elongation involved in DNA replication);GO:1902983(BP:DNA strand elongation involved in mitotic DNA replication);GO:0001833(BP:inner cell mass cell proliferation);GO:0005737(CC:cytoplasm);GO:0000811(CC:GINS complex);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0043138(MF:3'-5' DNA helicase activity)	-
P10619	0.736834	0.012508179	Lysosomal protective protein	5476	CTSA	GO:0006687(BP:glycosphingolipid metabolic process);GO:0006886(BP:intracellular protein transport);GO:1904715(BP:negative regulation of chaperone-mediated autophagy);GO:0043312(BP:neutrophil degranulation);GO:0006508(BP:proteolysis);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:1904714(BP:regulation of chaperone-mediated autophagy);GO:0031647(BP:regulation of protein stability);GO:0035578(CC:azurophil granule lumen);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0016020(CC:membrane);GO:0005654(CC:nucleoplasm);GO:0004180(MF:carboxypeptidase activity);GO:0008047(MF:enzyme activator activity);GO:0004185(MF:serine-type carboxypeptidase activity)	hsa04142(Lysosome);hsa04614(Renin-angiotensin system)
Q9H7Z6	0.735484	0.006134942	Histone acetyltransferase KAT8	84148	KAT8	"GO:0016573(BP:histone acetylation);GO:0043984(BP:histone H4-K16 acetylation);GO:0043981(BP:histone H4-K5 acetylation);GO:0043982(BP:histone H4-K8 acetylation);GO:0030099(BP:myeloid cell differentiation);GO:0045892(BP:negative regulation of transcription, DNA-templated);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0045893(BP:positive regulation of transcription, DNA-templated);GO:0010506(BP:regulation of autophagy);GO:0000123(CC:histone acetyltransferase complex);GO:0000776(CC:kinetochore);GO:0071339(CC:MLL1 complex);GO:0072487(CC:MSL complex);GO:0000790(CC:nuclear chromatin);GO:0016363(CC:nuclear matrix);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0016407(MF:acetyltransferase activity);GO:0019899(MF:enzyme binding);GO:0004402(MF:histone acetyltransferase activity);GO:0046972(MF:histone acetyltransferase activity (H4-K16 specific));GO:0042393(MF:histone binding);GO:0046872(MF:metal ion binding);GO:0035064(MF:methylated histone binding);GO:0008134(MF:transcription factor binding)"	-
P55061	0.728788	0.006407867	Bax inhibitor 1	7009	TMBIM6	GO:0006914(BP:autophagy);GO:0034620(BP:cellular response to unfolded protein);GO:0032469(BP:endoplasmic reticulum calcium ion homeostasis);GO:0070059(BP:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress);GO:0043066(BP:negative regulation of apoptotic process);GO:2001234(BP:negative regulation of apoptotic signaling pathway);GO:0010523(BP:negative regulation of calcium ion transport into cytosol);GO:1902236(BP:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:0060702(BP:negative regulation of endoribonuclease activity);GO:1903298(BP:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway);GO:0051025(BP:negative regulation of immunoglobulin secretion);GO:0032091(BP:negative regulation of protein binding);GO:0033119(BP:negative regulation of RNA splicing);GO:1990441(BP:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress);GO:1902065(BP:response to L-glutamate);GO:0005737(CC:cytoplasm);GO:0005783(CC:endoplasmic reticulum);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0005887(CC:integral component of plasma membrane);GO:0016020(CC:membrane);GO:0031966(CC:mitochondrial membrane);GO:0005634(CC:nucleus);GO:0060698(MF:endoribonuclease inhibitor activity);GO:0019899(MF:enzyme binding);GO:0031625(MF:ubiquitin protein ligase binding)	-
Q9GZV5	0.721595	0.008171156	WW domain-containing transcription regulator protein 1	25937	WWTR1	"GO:0060271(BP:cilium assembly);GO:0032835(BP:glomerulus development);GO:0003015(BP:heart process);GO:0035329(BP:hippo signaling);GO:0060993(BP:kidney morphogenesis);GO:0048762(BP:mesenchymal cell differentiation);GO:0035264(BP:multicellular organism growth);GO:0090090(BP:negative regulation of canonical Wnt signaling pathway);GO:0045599(BP:negative regulation of fat cell differentiation);GO:0006469(BP:negative regulation of protein kinase activity);GO:0001933(BP:negative regulation of protein phosphorylation);GO:0000122(BP:negative regulation of transcription by RNA polymerase II);GO:0001649(BP:osteoblast differentiation);GO:0008284(BP:positive regulation of cell proliferation);GO:0010718(BP:positive regulation of epithelial to mesenchymal transition);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0016567(BP:protein ubiquitination);GO:0072307(BP:regulation of metanephric nephron tubule epithelial cell differentiation);GO:0060390(BP:regulation of SMAD protein signal transduction);GO:0006355(BP:regulation of transcription, DNA-templated);GO:0031146(BP:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process);GO:0017145(BP:stem cell division);GO:0001894(BP:tissue homeostasis);GO:0006367(BP:transcription initiation from RNA polymerase II promoter);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0016604(CC:nuclear body);GO:0005654(CC:nucleoplasm);GO:0005634(CC:nucleus);GO:0005667(CC:transcription factor complex);GO:0042803(MF:protein homodimerization activity);GO:0003713(MF:transcription coactivator activity);GO:0003714(MF:transcription corepressor activity)"	hsa04392(Hippo signaling pathway - multiple species);hsa04390(Hippo signaling pathway)
P04818	0.715946	6.67E-05	Thymidylate synthase	7298	TYMS	"GO:0007568(BP:aging);GO:0051216(BP:cartilage development);GO:0007623(BP:circadian rhythm);GO:0048589(BP:developmental growth);GO:0071897(BP:DNA biosynthetic process);GO:0006231(BP:dTMP biosynthetic process);GO:0006235(BP:dTTP biosynthetic process);GO:0046078(BP:dUMP metabolic process);GO:0019088(BP:immortalization of host cell by virus);GO:0060574(BP:intestinal epithelial cell maturation);GO:0097421(BP:liver regeneration);GO:0017148(BP:negative regulation of translation);GO:0015949(BP:nucleobase-containing small molecule interconversion);GO:0000083(BP:regulation of transcription involved in G1/S transition of mitotic cell cycle);GO:0034097(BP:response to cytokine);GO:0045471(BP:response to ethanol);GO:0051593(BP:response to folic acid);GO:0051384(BP:response to glucocorticoid);GO:0046683(BP:response to organophosphorus);GO:0032570(BP:response to progesterone);GO:0033189(BP:response to vitamin A);GO:0035999(BP:tetrahydrofolate interconversion);GO:0019860(BP:uracil metabolic process);GO:0005737(CC:cytoplasm);GO:0005829(CC:cytosol);GO:0005743(CC:mitochondrial inner membrane);GO:0005759(CC:mitochondrial matrix);GO:0005739(CC:mitochondrion);GO:0005730(CC:nucleolus);GO:0005634(CC:nucleus);GO:0048037(MF:cofactor binding);GO:0005542(MF:folic acid binding);GO:0000166(MF:nucleotide binding);GO:0042803(MF:protein homodimerization activity);GO:1990825(MF:sequence-specific mRNA binding);GO:0004799(MF:thymidylate synthase activity);GO:0000900(MF:translation repressor activity, mRNA regulatory element binding)"	hsa00670(One carbon pool by folate);hsa00240(Pyrimidine metabolism);hsa01523(Antifolate resistance)
P07686	0.707581	0.000396764	Beta-hexosaminidase subunit beta	3074	HEXB	GO:0043615(BP:astrocyte cell migration);GO:0006874(BP:cellular calcium ion homeostasis);GO:0044267(BP:cellular protein metabolic process);GO:0030207(BP:chondroitin sulfate catabolic process);GO:0006689(BP:ganglioside catabolic process);GO:0006687(BP:glycosphingolipid metabolic process);GO:0030214(BP:hyaluronan catabolic process);GO:0042340(BP:keratan sulfate catabolic process);GO:0019915(BP:lipid storage);GO:0007626(BP:locomotory behavior);GO:0007040(BP:lysosome organization);GO:0008049(BP:male courtship behavior);GO:0042552(BP:myelination);GO:0050885(BP:neuromuscular process controlling balance);GO:0043312(BP:neutrophil degranulation);GO:0009313(BP:oligosaccharide catabolic process);GO:0048477(BP:oogenesis);GO:0007341(BP:penetration of zona pellucida);GO:0008654(BP:phospholipid biosynthetic process);GO:0045944(BP:positive regulation of transcription by RNA polymerase II);GO:0008360(BP:regulation of cell shape);GO:0007605(BP:sensory perception of sound);GO:0001501(BP:skeletal system development);GO:0001669(CC:acrosomal vesicle);GO:0042582(CC:azurophil granule);GO:0035578(CC:azurophil granule lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0043202(CC:lysosomal lumen);GO:0016020(CC:membrane);GO:0008375(MF:acetylglucosaminyltransferase activity);GO:0004563(MF:beta-N-acetylhexosaminidase activity);GO:0102148(MF:N-acetyl-beta-D-galactosaminidase activity);GO:0046982(MF:protein heterodimerization activity);GO:0042803(MF:protein homodimerization activity)	hsa00603(Glycosphingolipid biosynthesis - globo and isoglobo series);hsa00604(Glycosphingolipid biosynthesis - ganglio series);hsa00511(Other glycan degradation);hsa00531(Glycosaminoglycan degradation);hsa00520(Amino sugar and nucleotide sugar metabolism);hsa04142(Lysosome)
Q96RQ9	0.679685	0.008205262	L-amino-acid oxidase	259307	IL4I1	GO:0009063(BP:cellular amino acid catabolic process);GO:0006559(BP:L-phenylalanine catabolic process);GO:0005576(CC:extracellular region);GO:0005764(CC:lysosome);GO:0001716(MF:L-amino-acid oxidase activity);GO:0016491(MF:oxidoreductase activity)	"hsa00250(Alanine, aspartate and glutamate metabolism);hsa00350(Tyrosine metabolism);hsa00400(Phenylalanine, tyrosine and tryptophan biosynthesis);hsa00360(Phenylalanine metabolism);hsa00380(Tryptophan metabolism);hsa00270(Cysteine and methionine metabolism);hsa00280(Valine, leucine and isoleucine degradation)"
P38435	0.678051	0.014310093	Vitamin K-dependent gamma-carboxylase	2677	GGCX	GO:0007596(BP:blood coagulation);GO:0006464(BP:cellular protein modification process);GO:0017187(BP:peptidyl-glutamic acid carboxylation);GO:0005789(CC:endoplasmic reticulum membrane);GO:0016021(CC:integral component of membrane);GO:0016020(CC:membrane);GO:0008488(MF:gamma-glutamyl carboxylase activity)	hsa00130(Ubiquinone and other terpenoid-quinone biosynthesis)
P07858	0.665499	0.000935492	Cathepsin B	1508	CTSB	GO:0097067(BP:cellular response to thyroid hormone stimulus);GO:0030574(BP:collagen catabolic process);GO:0046697(BP:decidualization);GO:0030855(BP:epithelial cell differentiation);GO:0043312(BP:neutrophil degranulation);GO:0006508(BP:proteolysis);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:0042981(BP:regulation of apoptotic process);GO:0050790(BP:regulation of catalytic activity);GO:0002224(BP:toll-like receptor signaling pathway);GO:0046718(BP:viral entry into host cell);GO:0036021(CC:endolysosome lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1904813(CC:ficolin-1-rich granule lumen);GO:0005622(CC:intracellular);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005764(CC:lysosome);GO:0042470(CC:melanosome);GO:0005730(CC:nucleolus);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005518(MF:collagen binding);GO:0004197(MF:cysteine-type endopeptidase activity);GO:0008234(MF:cysteine-type peptidase activity);GO:0008233(MF:peptidase activity);GO:0043394(MF:proteoglycan binding)	hsa04210(Apoptosis);hsa04612(Antigen processing and presentation);hsa04140(Autophagy - animal);hsa04142(Lysosome);hsa04621(NOD-like receptor signaling pathway);hsa04924(Renin secretion)
P07711	0.664376	0.00306004	Cathepsin L1	1514	CTSL	GO:0002250(BP:adaptive immune response);GO:0019882(BP:antigen processing and presentation);GO:0019886(BP:antigen processing and presentation of exogenous peptide antigen via MHC class II);GO:0097067(BP:cellular response to thyroid hormone stimulus);GO:0030574(BP:collagen catabolic process);GO:0022617(BP:extracellular matrix disassembly);GO:0071888(BP:macrophage apoptotic process);GO:0006508(BP:proteolysis);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:0045616(BP:regulation of keratinocyte differentiation);GO:0002224(BP:toll-like receptor signaling pathway);GO:0036021(CC:endolysosome lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0005771(CC:multivesicular body);GO:0005634(CC:nucleus);GO:0005886(CC:plasma membrane);GO:0005518(MF:collagen binding);GO:0004197(MF:cysteine-type endopeptidase activity);GO:0008234(MF:cysteine-type peptidase activity);GO:0001968(MF:fibronectin binding);GO:0042393(MF:histone binding);GO:0043394(MF:proteoglycan binding);GO:0097655(MF:serpin family protein binding)	hsa05323(Rheumatoid arthritis);hsa04140(Autophagy - animal);hsa04612(Antigen processing and presentation);hsa05418(Fluid shear stress and atherosclerosis);hsa04142(Lysosome);hsa04145(Phagosome);hsa05205(Proteoglycans in cancer);hsa04210(Apoptosis)
P06865	0.64587	0.009156367	Beta-hexosaminidase subunit alpha	3073	HEXA	GO:0005975(BP:carbohydrate metabolic process);GO:0030207(BP:chondroitin sulfate catabolic process);GO:0006024(BP:glycosaminoglycan biosynthetic process);GO:0006687(BP:glycosphingolipid metabolic process);GO:0030214(BP:hyaluronan catabolic process);GO:0042340(BP:keratan sulfate catabolic process);GO:0042582(CC:azurophil granule);GO:0070062(CC:extracellular exosome);GO:0043202(CC:lysosomal lumen);GO:0016020(CC:membrane);GO:0008375(MF:acetylglucosaminyltransferase activity);GO:0004563(MF:beta-N-acetylhexosaminidase activity);GO:0102148(MF:N-acetyl-beta-D-galactosaminidase activity);GO:0046982(MF:protein heterodimerization activity)	hsa00603(Glycosphingolipid biosynthesis - globo and isoglobo series);hsa00531(Glycosaminoglycan degradation);hsa00511(Other glycan degradation);hsa00604(Glycosphingolipid biosynthesis - ganglio series);hsa00520(Amino sugar and nucleotide sugar metabolism);hsa04142(Lysosome)
Q9HB40	0.643929	1.14E-05	Retinoid-inducible serine carboxypeptidase	59342	SCPEP1	GO:0045776(BP:negative regulation of blood pressure);GO:0097755(BP:positive regulation of blood vessel diameter);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:0042573(BP:retinoic acid metabolic process);GO:0005829(CC:cytosol);GO:0070062(CC:extracellular exosome);GO:0004185(MF:serine-type carboxypeptidase activity)	-
O14773	0.626873	0.000654845	Tripeptidyl-peptidase 1	1200	TPP1	GO:0045453(BP:bone resorption);GO:0007417(BP:central nervous system development);GO:0030855(BP:epithelial cell differentiation);GO:0036498(BP:IRE1-mediated unfolded protein response);GO:0006629(BP:lipid metabolic process);GO:0007040(BP:lysosome organization);GO:0007399(BP:nervous system development);GO:0050885(BP:neuromuscular process controlling balance);GO:0043171(BP:peptide catabolic process);GO:0030163(BP:protein catabolic process);GO:0006508(BP:proteolysis);GO:0070062(CC:extracellular exosome);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0042470(CC:melanosome);GO:0004175(MF:endopeptidase activity);GO:0046872(MF:metal ion binding);GO:0008233(MF:peptidase activity);GO:0042277(MF:peptide binding);GO:0004252(MF:serine-type endopeptidase activity);GO:0008236(MF:serine-type peptidase activity);GO:0008240(MF:tripeptidyl-peptidase activity)	hsa04142(Lysosome)
Q9UBR2	0.578096	0.000251107	Cathepsin Z	1522	CTSZ	GO:0002003(BP:angiotensin maturation);GO:0048208(BP:COPII vesicle coating);GO:0006888(BP:ER to Golgi vesicle-mediated transport);GO:0060441(BP:epithelial tube branching involved in lung morphogenesis);GO:0010977(BP:negative regulation of neuron projection development);GO:0010757(BP:negative regulation of plasminogen activation);GO:0032091(BP:negative regulation of protein binding);GO:0043312(BP:neutrophil degranulation);GO:2000179(BP:positive regulation of neural precursor cell proliferation);GO:0043525(BP:positive regulation of neuron apoptotic process);GO:0006508(BP:proteolysis);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:1901214(BP:regulation of neuron death);GO:0099738(CC:cell cortex region);GO:0009986(CC:cell surface);GO:0030134(CC:COPII-coated ER to Golgi transport vesicle);GO:0031410(CC:cytoplasmic vesicle);GO:0005783(CC:endoplasmic reticulum);GO:0005788(CC:endoplasmic reticulum lumen);GO:0033116(CC:endoplasmic reticulum-Golgi intermediate compartment membrane);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:1904813(CC:ficolin-1-rich granule lumen);GO:0000139(CC:Golgi membrane);GO:0030426(CC:growth cone);GO:0043231(CC:intracellular membrane-bounded organelle);GO:0005764(CC:lysosome);GO:0005886(CC:plasma membrane);GO:0035580(CC:specific granule lumen);GO:0004180(MF:carboxypeptidase activity);GO:0004197(MF:cysteine-type endopeptidase activity);GO:0008234(MF:cysteine-type peptidase activity)	hsa04210(Apoptosis);hsa04142(Lysosome)
Q99538	0.545192	0.000375215	Legumain	5641	LGMN	GO:0097202(BP:activation of cysteine-type endopeptidase activity);GO:0019886(BP:antigen processing and presentation of exogenous peptide antigen via MHC class II);GO:0008306(BP:associative learning);GO:1904646(BP:cellular response to amyloid-beta);GO:0071277(BP:cellular response to calcium ion);GO:0035729(BP:cellular response to hepatocyte growth factor stimulus);GO:0097061(BP:dendritic spine organization);GO:0007613(BP:memory);GO:1901185(BP:negative regulation of ERBB signaling pathway);GO:0010629(BP:negative regulation of gene expression);GO:0040015(BP:negative regulation of multicellular organism growth);GO:0043524(BP:negative regulation of neuron apoptotic process);GO:0008284(BP:positive regulation of cell proliferation);GO:2001028(BP:positive regulation of endothelial cell chemotaxis);GO:1900273(BP:positive regulation of long-term synaptic potentiation);GO:0045931(BP:positive regulation of mitotic cell cycle);GO:0090026(BP:positive regulation of monocyte chemotaxis);GO:0006508(BP:proteolysis);GO:0051603(BP:proteolysis involved in cellular protein catabolic process);GO:0032801(BP:receptor catabolic process);GO:0003014(BP:renal system process);GO:0010447(BP:response to acidic pH);GO:0097264(BP:self proteolysis);GO:0002224(BP:toll-like receptor signaling pathway);GO:0006624(BP:vacuolar protein processing);GO:0042359(BP:vitamin D metabolic process);GO:0045177(CC:apical part of cell);GO:0005737(CC:cytoplasm);GO:0036021(CC:endolysosome lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005770(CC:late endosome);GO:0043202(CC:lysosomal lumen);GO:0005764(CC:lysosome);GO:0048471(CC:perinuclear region of cytoplasm);GO:0004197(MF:cysteine-type endopeptidase activity);GO:0008233(MF:peptidase activity);GO:0048156(MF:tau protein binding)	hsa04142(Lysosome);hsa04612(Antigen processing and presentation)
O75503	0.468181	1.15E-05	Ceroid-lipofuscinosis neuronal protein 5	1203	CLN5	"GO:0007420(BP:brain development);GO:0070085(BP:glycosylation);GO:0007042(BP:lysosomal lumen acidification);GO:0022008(BP:neurogenesis);GO:0042551(BP:neuron maturation);GO:1904426(BP:positive regulation of GTP binding);GO:0030163(BP:protein catabolic process);GO:0042147(BP:retrograde transport, endosome to Golgi);GO:0006465(BP:signal peptide processing);GO:0005829(CC:cytosol);GO:0005783(CC:endoplasmic reticulum);GO:0070062(CC:extracellular exosome);GO:0005794(CC:Golgi apparatus);GO:0016021(CC:integral component of membrane);GO:0005765(CC:lysosomal membrane);GO:0005764(CC:lysosome);GO:0048471(CC:perinuclear region of cytoplasm);GO:0005537(MF:mannose binding)"	hsa04142(Lysosome)
Q9BTY2	0.386984	1.54E-05	Plasma alpha-L-fucosidase	2519	FUCA2	GO:0044267(BP:cellular protein metabolic process);GO:0006004(BP:fucose metabolic process);GO:0016139(BP:glycoside catabolic process);GO:0043312(BP:neutrophil degranulation);GO:0043687(BP:post-translational protein modification);GO:2000535(BP:regulation of entry of bacterium into host cell);GO:0009617(BP:response to bacterium);GO:0035578(CC:azurophil granule lumen);GO:0005788(CC:endoplasmic reticulum lumen);GO:0070062(CC:extracellular exosome);GO:0005576(CC:extracellular region);GO:0005615(CC:extracellular space);GO:0005764(CC:lysosome);GO:0004560(MF:alpha-L-fucosidase activity)	hsa00511(Other glycan degradation)