Biomaker_names Logarithm value Groups LDA_value P_value L1_Environmental_Information_Processing.L2_Signal_Transduction.L3_Notch_signaling_pathway 0.0 - L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Valine__leucine_and_isoleucine_degradation 3.34125930464 CKD 2.20284341836 5.54268609089e-10 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Germination 2.62028557534 2.98887763041e-07 L1_Unclassified.L2_Metabolism.L3_Others 3.9626252424 CKD 2.47366206985 2.79170294707e-09 L1_Human_Diseases.L2_Infectious_Diseases.L3_Tuberculosis 3.18502780755 0.00420583114719 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Arginine_and_proline_metabolism 4.10802714472 HC 2.37248123729 1.27805288699e-08 L1_Cellular_Processes.L2_Cell_Growth_and_Death.L3_Cell_cycle___Caulobacter 3.71689631231 HC 2.28881711191 2.15103176901e-06 L1_Genetic_Information_Processing.L2_Translation.L3_Aminoacyl_tRNA_biosynthesis 4.06282306647 HC 2.56011586911 0.000529665738405 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Glycosphingolipid_biosynthesis___globo_series 3.14532306991 - L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_D_Arginine_and_D_ornithine_metabolism 1.46636885239 - L1_Metabolism.L2_Enzyme_Families.L3_Protein_kinases 3.49510264586 CKD 2.1038794796 0.0148452480116 L1_Genetic_Information_Processing.L2_Transcription.L3_Basal_transcription_factors 1.19464024835 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Drug_metabolism___other_enzymes 3.53414496712 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Naphthalene_degradation 3.15685242054 1.76503489187e-16 L1_Metabolism.L2_Energy_Metabolism.L3_Sulfur_metabolism 3.45322932042 0.00223614423215 L1_Environmental_Information_Processing.L2_Membrane_Transport.L3_Phosphotransferase_system__PTS_ 3.66206203078 CKD 2.7431064808 0.00230348579563 L1_Metabolism.L2_Lipid_Metabolism.L3_Biosynthesis_of_unsaturated_fatty_acids 3.12740024006 CKD 2.1488336024 9.057711036e-09 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Tyrosine_metabolism 3.53669494759 CKD 2.01695114155 9.92297442839e-13 L1_Cellular_Processes.L2_Cell_Growth_and_Death.L3_Apoptosis 0.931353668296 3.76075156882e-05 L1_Cellular_Processes.L2_Cell_Motility.L3_Cytoskeleton_proteins 3.61589390894 HC 2.37479469761 4.09501175788e-08 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Biosynthesis_of_type_II_polyketide_products 0.0 - L1_Organismal_Systems.L2_Environmental_Adaptation.L3_Plant_pathogen_interaction 3.20632775085 2.76941383377e-11 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Polyketide_sugar_unit_biosynthesis 3.36018656153 HC 2.0823064416 7.04488493151e-08 L1_Metabolism.L2_Energy_Metabolism.L3_Nitrogen_metabolism 3.8665683241 CKD 2.20730440643 8.48915120178e-06 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Lipopolysaccharide_biosynthesis_proteins 3.63971750835 CKD 2.76636410717 8.6958397197e-10 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Zeatin_biosynthesis 2.77049471937 - L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_Taurine_and_hypotaurine_metabolism 3.04216815449 0.00108269557636 L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_DNA_replication 3.8234923607 - L1_Human_Diseases.L2_Neurodegenerative_Diseases.L3_Parkinsons_disease 0.850395692652 - L1_Human_Diseases.L2_Neurodegenerative_Diseases.L3_Alzheimers_disease 2.6794153098 0.0224772701055 L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Penicillin_and_cephalosporin_biosynthesis 2.45850185376 7.17751346314e-05 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Lysine_degradation 3.12716832653 CKD 2.18482205263 1.19843009755e-10 L1_Unclassified.L2_Poorly_Characterized.L3_Function_unknown 4.12701853896 CKD 2.98892229747 4.84458549375e-21 L1_Metabolism.L2_Lipid_Metabolism.L3_Steroid_hormone_biosynthesis 2.47723384375 0.00839250574512 L1_Human_Diseases.L2_Cancers.L3_Colorectal_cancer 0.222765512062 1.06180657919e-09 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Polycyclic_aromatic_hydrocarbon_degradation 3.05550776506 3.75712117735e-17 L1_Environmental_Information_Processing.L2_Signal_Transduction.L3_Calcium_signaling_pathway 0.0 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Chagas_disease__American_trypanosomiasis_ 1.63929688637 6.4062553304e-18 L1_Human_Diseases.L2_Cancers.L3_Chronic_myeloid_leukemia 0.0 - L1_Human_Diseases.L2_Neurodegenerative_Diseases.L3_Prion_diseases 1.80885049832 7.09958098707e-22 L1_Organismal_Systems.L2_Environmental_Adaptation.L3_Circadian_rhythm___plant 0.708826319538 0.0240438897844 L1_Organismal_Systems.L2_Digestive_System.L3_Protein_digestion_and_absorption 2.46342598599 - L1_Organismal_Systems.L2_Immune_System.L3_RIG_I_like_receptor_signaling_pathway 1.22706524525 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Vibrio_cholerae_infection 0.0 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Tropane__piperidine_and_pyridine_alkaloid_biosynthesis 3.08874993569 - L1_Organismal_Systems.L2_Digestive_System.L3_Carbohydrate_digestion_and_absorption 2.23334733216 0.000117149768182 L1_Human_Diseases.L2_Neurodegenerative_Diseases.L3_Amyotrophic_lateral_sclerosis__ALS_ 2.22309075036 1.08813592776e-23 L1_Organismal_Systems.L2_Immune_System.L3_NOD_like_receptor_signaling_pathway 2.67899922807 0.000222736869168 L1_Environmental_Information_Processing.L2_Signaling_Molecules_and_Interaction.L3_Cellular_antigens 2.71218851311 - L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Other_transporters 3.46263393915 CKD 2.08264186318 1.39713468262e-20 L1_Human_Diseases.L2_Infectious_Diseases.L3_Staphylococcus_aureus_infection 1.44992190547 7.10143721534e-06 L1_Metabolism.L2_Energy_Metabolism.L3_Photosynthesis_proteins 3.64789391572 HC 2.64449481261 7.88233006626e-33 L1_Organismal_Systems.L2_Endocrine_System.L3_PPAR_signaling_pathway 3.05801124373 - L1_Unclassified.L2_Metabolism.L3_Glycan_biosynthesis_and_metabolism 2.66832695468 CKD 2.07962653588 2.47445391325e-23 L1_Organismal_Systems.L2_Endocrine_System.L3_Insulin_signaling_pathway 2.94352865078 - L1_Human_Diseases.L2_Cancers.L3_Bladder_cancer 1.4969003632 2.95526827987e-16 L1_Metabolism.L2_Energy_Metabolism.L3_Oxidative_phosphorylation 4.06961500075 HC 2.45220095212 3.13338866087e-07 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Limonene_and_pinene_degradation 2.95791145994 CKD 2.01246463393 8.9292807965e-15 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Pentose_phosphate_pathway 3.95994394148 - L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Ascorbate_and_aldarate_metabolism 3.14025462438 CKD 2.40935397164 1.2824501084e-21 L1_Genetic_Information_Processing.L2_Translation.L3_Ribosome_biogenesis_in_eukaryotes 2.6711465718 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_beta_Lactam_resistance 2.49268240293 0.000512394227437 L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_Nucleotide_excision_repair 3.60045411671 HC 2.16353586788 0.00140778141082 L1_Metabolism.L2_Lipid_Metabolism.L3_Glycerophospholipid_metabolism 3.73663951046 - L1_Unclassified.L2_Poorly_Characterized.L3_General_function_prediction_only 4.56680320151 HC 2.48583716271 4.43541882985e-05 L1_Human_Diseases.L2_Cancers.L3_Renal_cell_carcinoma 1.76316123518 8.96381555844e-21 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Cysteine_and_methionine_metabolism 3.98385699772 - L1_Environmental_Information_Processing.L2_Membrane_Transport.L3_Transporters 4.8194775459 - L1_Cellular_Processes.L2_Cell_Growth_and_Death.L3_Cell_cycle 0.0 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Stilbenoid__diarylheptanoid_and_gingerol_biosynthesis 0.462405568619 1.65634833091e-11 L1_Unclassified.L2_Metabolism.L3_Energy_metabolism 3.95836839372 0.00735382412332 L1_Human_Diseases.L2_Metabolic_Diseases.L3_Type_II_diabetes_mellitus 2.70041443014 0.00710609574517 L1_Metabolism.L2_Energy_Metabolism.L3_Photosynthesis___antenna_proteins 0.0 - L1_Cellular_Processes.L2_Cell_Growth_and_Death.L3_p53_signaling_pathway 0.222982943319 1.2512629302e-09 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Propanoate_metabolism 3.69881059461 CKD 2.08097410001 0.000108913501316 L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Retinol_metabolism 2.52179666996 9.13022112074e-13 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Inorganic_ion_transport_and_metabolism 3.36216513903 CKD 2.51680059385 7.31956976596e-18 L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Biotin_metabolism 3.19814548337 - L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Cell_division 2.94163712424 6.44669182419e-09 L1_Genetic_Information_Processing.L2_Folding__Sorting_and_Degradation.L3_RNA_degradation 3.67858846573 - L1_Environmental_Information_Processing.L2_Signal_Transduction.L3_mTOR_signaling_pathway 0.0 - L1_Organismal_Systems.L2_Excretory_System.L3_Proximal_tubule_bicarbonate_reclamation 2.42714738348 1.96122480044e-14 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Histidine_metabolism 3.80025456567 - L1_Unclassified.L2_Genetic_Information_Processing.L3_Translation_proteins 3.952825713 - L1_Unclassified.L2_Genetic_Information_Processing.L3_Transcription_related_proteins 1.99858322515 3.00499668525e-19 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Carotenoid_biosynthesis 1.68253856814 8.15695341397e-19 L1_Metabolism.L2_Energy_Metabolism.L3_Carbon_fixation_in_photosynthetic_organisms 3.82680131652 - L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_Non_homologous_end_joining 1.90799096867 2.48267973675e-08 L1_Human_Diseases.L2_Cancers.L3_Pathways_in_cancer 2.6767988293 - L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_Mismatch_repair 3.92413559047 HC 2.34599283072 0.00163383166211 L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_D_Alanine_metabolism 3.0218130751 0.00729811337499 L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Nicotinate_and_nicotinamide_metabolism 3.64005087768 - L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Thiamine_metabolism 3.71898632643 HC 2.27445990706 3.5775878777e-20 L1_Cellular_Processes.L2_Transport_and_Catabolism.L3_Endocytosis 0.0 - L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Tetracycline_biosynthesis 3.15361317677 4.19870244105e-05 L1_Environmental_Information_Processing.L2_Membrane_Transport.L3_ABC_transporters 4.5159921419 HC 2.56605576862 0.0418095437847 L1_Human_Diseases.L2_Immune_System_Diseases.L3_Systemic_lupus_erythematosus 0.709151318214 - L1_Organismal_Systems.L2_Endocrine_System.L3_Progesterone_mediated_oocyte_maturation 2.6564192376 2.43798694404e-06 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Benzoate_degradation 3.35180607644 CKD 2.08976802589 3.95217422141e-05 L1_Metabolism.L2_Lipid_Metabolism.L3_Glycerolipid_metabolism 3.57637640982 CKD 2.00158665535 0.000920032869526 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Fructose_and_mannose_metabolism 4.00918564545 - L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Glycosphingolipid_biosynthesis___lacto_and_neolacto_series 0.624807468056 0.0155911080043 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Lysine_biosynthesis 3.94309608515 HC 2.51337526537 1.08169959673e-13 L1_Environmental_Information_Processing.L2_Signal_Transduction.L3_Wnt_signaling_pathway 0.0 - L1_Unclassified.L2_Metabolism.L3_Lipid_metabolism 3.14098616223 0.00581594372601 L1_Genetic_Information_Processing.L2_Folding__Sorting_and_Degradation.L3_Sulfur_relay_system 3.42206043396 - L1_Human_Diseases.L2_Cardiovascular_Diseases.L3_Hypertrophic_cardiomyopathy__HCM_ 0.0 - L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Porphyrin_and_chlorophyll_metabolism 4.01394342987 HC 2.83693688393 9.13549986399e-18 L1_Metabolism.L2_Energy_Metabolism.L3_Photosynthesis 3.64640020304 HC 2.65924987832 3.39203142841e-33 L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_One_carbon_pool_by_folate 3.81793547407 HC 2.29637006316 0.0268625478122 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Lipopolysaccharide_biosynthesis 3.46302572344 CKD 2.57900895861 5.49357704134e-08 L1_Human_Diseases.L2_Infectious_Diseases.L3_Influenza_A 0.226737190368 2.10907371361e-08 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Ethylbenzene_degradation 2.6678513153 0.0224772701055 L1_Human_Diseases.L2_Infectious_Diseases.L3_Bacterial_invasion_of_epithelial_cells 1.25569697411 6.79637136256e-22 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Pentose_and_glucuronate_interconversions 3.80048921809 CKD 2.19927900366 0.0114803931125 L1_Environmental_Information_Processing.L2_Signal_Transduction.L3_Two_component_system 4.16057290262 CKD 2.91772799674 1.63267379437e-05 L1_Metabolism.L2_Lipid_Metabolism.L3_Sphingolipid_metabolism 3.44128466795 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Drug_metabolism___cytochrome_P450 2.56170114642 CKD 2.02980683441 1.00014085826e-22 L1_Genetic_Information_Processing.L2_Translation.L3_Ribosome_Biogenesis 4.14868624973 HC 2.34656655565 0.000598680121641 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Biosynthesis_of_siderophore_group_nonribosomal_peptides 2.60459221197 CKD 2.05347384727 2.04375655043e-11 L1_Metabolism.L2_Nucleotide_Metabolism.L3_Purine_metabolism 4.34800675195 - L1_Human_Diseases.L2_Metabolic_Diseases.L3_Type_I_diabetes_mellitus 2.71969918137 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Epithelial_cell_signaling_in_Helicobacter_pylori_infection 3.00556768789 7.36766988535e-22 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Aminobenzoate_degradation 3.09811671309 5.41152435871e-09 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Fluorobenzoate_degradation 1.78197166796 1.34510288941e-13 L1_Human_Diseases.L2_Infectious_Diseases.L3_Hepatitis_C 0.0 - L1_Organismal_Systems.L2_Immune_System.L3_Antigen_processing_and_presentation 2.6564192376 2.43798694404e-06 L1_Genetic_Information_Processing.L2_Folding__Sorting_and_Degradation.L3_Protein_export 3.77417217634 - L1_Environmental_Information_Processing.L2_Signal_Transduction.L3_Phosphatidylinositol_signaling_system 2.95081346151 1.31840545283e-14 L1_Genetic_Information_Processing.L2_Translation.L3_RNA_transport 3.16244057004 4.97094214663e-12 L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Streptomycin_biosynthesis 3.53530440075 - L1_Metabolism.L2_Lipid_Metabolism.L3_Secondary_bile_acid_biosynthesis 2.55824809886 - L1_Cellular_Processes.L2_Cell_Motility.L3_Bacterial_motility_proteins 3.85375506402 - L1_Organismal_Systems.L2_Circulatory_System.L3_Cardiac_muscle_contraction 0.730667895147 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Toxoplasmosis 0.222765512062 1.06180657919e-09 L1_Organismal_Systems.L2_Endocrine_System.L3_GnRH_signaling_pathway 0.0 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Pathogenic_Escherichia_coli_infection 0.0 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Butirosin_and_neomycin_biosynthesis 2.86901489125 - L1_Organismal_Systems.L2_Digestive_System.L3_Bile_secretion 0.512209257222 2.13817688194e-13 L1_Environmental_Information_Processing.L2_Signaling_Molecules_and_Interaction.L3_Bacterial_toxins 3.05123490449 - L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Amino_acid_related_enzymes 4.180015334 HC 2.60116142629 1.08446368252e-08 L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Betalain_biosynthesis 0.0 - L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Ubiquinone_and_other_terpenoid_quinone_biosynthesis 3.32114510855 CKD 2.53070701329 4.40885872629e-11 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Alanine__aspartate_and_glutamate_metabolism 4.05665241221 HC 2.37122482246 0.00208894153641 L1_Cellular_Processes.L2_Transport_and_Catabolism.L3_Peroxisome 3.25495938758 0.000461469633107 L1_Human_Diseases.L2_Immune_System_Diseases.L3_Primary_immunodeficiency 2.64639450764 - L1_Metabolism.L2_Lipid_Metabolism.L3_Steroid_biosynthesis 1.18817703822 4.15159355671e-07 L1_Genetic_Information_Processing.L2_Translation.L3_Translation_factors 3.73588880174 HC 2.15521650502 0.00702520019318 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Biosynthesis_of_vancomycin_group_antibiotics 2.83674881691 0.00443057281912 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Peptidoglycan_biosynthesis 3.93167530292 HC 2.47033074444 2.56276810236e-06 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Signal_transduction_mechanisms 3.66999659361 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Chlorocyclohexane_and_chlorobenzene_degradation 1.99922345013 - L1_Environmental_Information_Processing.L2_Membrane_Transport.L3_Bacterial_secretion_system 3.8072233272 CKD 2.6442546766 1.09676710914e-18 L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_DNA_replication_proteins 4.10674839056 HC 2.46976406712 0.0139807082805 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Starch_and_sucrose_metabolism 4.05834808147 HC 2.45544361117 0.00152358949953 L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_Base_excision_repair 3.63651418537 0.00660756301903 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Metabolism_of_xenobiotics_by_cytochrome_P450 2.5571221179 CKD 2.0207355462 2.04676665972e-22 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Amino_sugar_and_nucleotide_sugar_metabolism 4.18522838477 - L1_Metabolism.L2_Lipid_Metabolism.L3_Lipid_biosynthesis_proteins 3.76814801811 0.000335609333381 L1_Cellular_Processes.L2_Cell_Growth_and_Death.L3_Meiosis___yeast 1.39631529443 9.02896795743e-07 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Various_types_of_N_glycan_biosynthesis 0.166240700446 5.03829445704e-15 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Cell_motility_and_secretion 3.2547610915 CKD 2.10466199027 1.58969215489e-09 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Tryptophan_metabolism 3.16663115999 CKD 2.34455761481 9.45278269159e-14 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Other_ion_coupled_transporters 4.14365595813 CKD 2.54879860596 3.88736194354e-05 L1_Metabolism.L2_Lipid_Metabolism.L3_alpha_Linolenic_acid_metabolism 1.95371070392 1.90431745387e-30 L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_DNA_repair_and_recombination_proteins 4.45684869093 - L1_Genetic_Information_Processing.L2_Folding__Sorting_and_Degradation.L3_Proteasome 2.66494450425 5.05624103168e-05 L1_Human_Diseases.L2_Infectious_Diseases.L3_African_trypanosomiasis 1.65686027654 2.4234851581e-21 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Pores_ion_channels 3.62862175587 CKD 2.6651549345 5.70812767724e-09 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Inositol_phosphate_metabolism 3.05906983861 CKD 2.13317640113 1.56806380831e-17 L1_Metabolism.L2_Lipid_Metabolism.L3_Fatty_acid_metabolism 3.38295767343 CKD 2.28733561866 1.66485255165e-13 L1_Organismal_Systems.L2_Endocrine_System.L3_Adipocytokine_signaling_pathway 2.87432387734 - L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Vitamin_B6_metabolism 3.33251694915 8.85483011133e-07 L1_Organismal_Systems.L2_Digestive_System.L3_Mineral_absorption 1.82610588811 0.0447045336772 L1_Human_Diseases.L2_Neurodegenerative_Diseases.L3_Huntingtons_disease 2.44607434 2.78699930408e-24 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Butanoate_metabolism 3.80669597068 CKD 2.25771888677 3.71942519857e-05 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_N_Glycan_biosynthesis 2.39390730059 3.86598295668e-05 L1_Cellular_Processes.L2_Transport_and_Catabolism.L3_Phagosome 0.0 - L1_Genetic_Information_Processing.L2_Translation.L3_mRNA_surveillance_pathway 0.0 - L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Phenylalanine_metabolism 3.30595354453 CKD 2.13814007649 1.55788400385e-12 L1_Unclassified.L2_Metabolism.L3_Biosynthesis_and_biodegradation_of_secondary_metabolites 2.91459638171 CKD 2.0013062925 4.91870983847e-06 L1_Organismal_Systems.L2_Endocrine_System.L3_Renin_angiotensin_system 0.0 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Atrazine_degradation 2.28022500442 0.0150553896944 L1_Unclassified.L2_Metabolism.L3_Nucleotide_metabolism 2.73751182503 CKD 2.07170668718 3.06090432999e-16 L1_Metabolism.L2_Lipid_Metabolism.L3_Synthesis_and_degradation_of_ketone_bodies 2.40996581662 0.0147931181484 L1_Metabolism.L2_Nucleotide_Metabolism.L3_Pyrimidine_metabolism 4.27770110244 HC 2.68242314717 0.0321717622652 L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Pantothenate_and_CoA_biosynthesis 3.81897940221 HC 2.29465376898 1.10659522826e-21 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Electron_transfer_carriers 2.47956784766 CKD 2.03545389235 2.77967533471e-31 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Geraniol_degradation 2.76271740678 CKD 2.18864775492 5.80683393983e-16 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Sporulation 3.91428426118 HC 2.96196854531 2.37086929147e-09 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Glyoxylate_and_dicarboxylate_metabolism 3.74305854526 CKD 2.19868966378 7.71963838794e-06 L1_Genetic_Information_Processing.L2_Folding__Sorting_and_Degradation.L3_Chaperones_and_folding_catalysts 4.01946708434 - L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Citrate_cycle__TCA_cycle_ 3.81161762907 CKD 2.37562512627 7.37811173902e-07 L1_Genetic_Information_Processing.L2_Transcription.L3_RNA_polymerase 3.20408152113 5.0394942288e-06 L1_Metabolism.L2_Energy_Metabolism.L3_Carbon_fixation_pathways_in_prokaryotes 4.01438364581 - L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Prenyltransferases 3.50765176856 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Shigellosis 0.0 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Caffeine_metabolism 0.70871891676 - L1_Metabolism.L2_Lipid_Metabolism.L3_Linoleic_acid_metabolism 2.84583541574 0.0157016169619 L1_Environmental_Information_Processing.L2_Signal_Transduction.L3_MAPK_signaling_pathway___yeast 2.68596742219 - L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Glycosphingolipid_biosynthesis___ganglio_series 2.86170974435 - L1_Genetic_Information_Processing.L2_Transcription.L3_Transcription_machinery 4.03623760948 HC 2.64824925389 9.32654935733e-07 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Galactose_metabolism 3.92473963145 - L1_Human_Diseases.L2_Cancers.L3_Small_cell_lung_cancer 0.222765512062 1.06180657919e-09 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Glycosyltransferases 3.5422484125 CKD 2.11791127219 0.000158754608914 L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_Chromosome 4.20838720082 HC 2.42478223604 0.0395604529978 L1_Genetic_Information_Processing.L2_Folding__Sorting_and_Degradation.L3_Protein_processing_in_endoplasmic_reticulum 2.8471127868 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Bisphenol_degradation 2.91668333971 - L1_Environmental_Information_Processing.L2_Signaling_Molecules_and_Interaction.L3_Ion_channels 2.19018824959 1.84901223501e-13 L1_Human_Diseases.L2_Infectious_Diseases.L3_Pertussis 2.75626587091 CKD 2.30462136179 6.52324574629e-17 L1_Unclassified.L2_Cellular_Processes_and_Signaling.L3_Membrane_and_intracellular_structural_molecules 3.78880409002 CKD 2.63818129669 1.01338556482e-05 L1_Genetic_Information_Processing.L2_Transcription.L3_Transcription_factors 4.24579576383 - L1_Environmental_Information_Processing.L2_Membrane_Transport.L3_Secretion_system 4.07759201847 CKD 3.01516960585 3.11534091542e-13 L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Flavone_and_flavonol_biosynthesis 1.82125650688 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Measles 0.0 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Flavonoid_biosynthesis 1.68128440722 5.73619084499e-15 L1_Unclassified.L2_Metabolism.L3_Metabolism_of_cofactors_and_vitamins 3.07026016522 0.000183970800493 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Chloroalkane_and_chloroalkene_degradation 3.23083408333 - L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_Selenocompound_metabolism 3.55661860356 2.89595687562e-05 L1_Unclassified.L2_Genetic_Information_Processing.L3_Replication__recombination_and_repair_proteins 3.90022420419 0.0195103235665 L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_Phosphonate_and_phosphinate_metabolism 2.81584497971 1.40114878613e-09 L1_Metabolism.L2_Lipid_Metabolism.L3_Primary_bile_acid_biosynthesis 2.56489038344 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Indole_alkaloid_biosynthesis 0.0 - L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Biosynthesis_of_ansamycins 3.0713519317 - L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_D_Glutamine_and_D_glutamate_metabolism 3.17757818117 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Vibrio_cholerae_pathogenic_cycle 2.90900967455 0.000226103451974 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Toluene_degradation 3.02114502134 0.00134700581605 L1_Environmental_Information_Processing.L2_Signaling_Molecules_and_Interaction.L3_G_protein_coupled_receptors 0.0 - L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Lipoic_acid_metabolism 2.58427743111 4.19748817671e-19 L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Other_glycan_degradation 3.57373476403 - L1_Metabolism.L2_Glycan_Biosynthesis_and_Metabolism.L3_Glycosaminoglycan_degradation 3.00174575943 - L1_Genetic_Information_Processing.L2_Folding__Sorting_and_Degradation.L3_Ubiquitin_system 2.11878487515 2.65209012906e-11 L1_Metabolism.L2_Lipid_Metabolism.L3_Fatty_acid_elongation_in_mitochondria 0.708609194562 - L1_Metabolism.L2_Energy_Metabolism.L3_Methane_metabolism 4.12097772747 HC 2.66725956311 9.43883134831e-12 L1_Organismal_Systems.L2_Nervous_System.L3_Glutamatergic_synapse 3.07014904644 1.78058074785e-06 L1_Human_Diseases.L2_Cardiovascular_Diseases.L3_Viral_myocarditis 0.222765512062 CKD 2.00142125635 1.06180657919e-09 L1_Cellular_Processes.L2_Transport_and_Catabolism.L3_Lysosome 3.17378671617 - L1_Human_Diseases.L2_Cancers.L3_Prostate_cancer 2.66918405752 0.00301101248237 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Dioxin_degradation 2.78612039111 2.23259501649e-07 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Glycolysis___Gluconeogenesis 4.05440702018 0.00135896377857 L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Riboflavin_metabolism 3.41027418394 0.0253250742764 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Xylene_degradation 2.74483323301 5.00903457368e-06 L1_Metabolism.L2_Carbohydrate_Metabolism.L3_C5_Branched_dibasic_acid_metabolism 3.51727816756 7.24712329572e-08 L1_Unclassified.L2_Metabolism.L3_Carbohydrate_metabolism 3.27526619101 - L1_Metabolism.L2_Carbohydrate_Metabolism.L3_Pyruvate_metabolism 4.02584261809 CKD 2.19942279396 0.00254871829235 L1_Genetic_Information_Processing.L2_Translation.L3_Ribosome 4.37943569211 HC 2.92514298776 0.000484001850181 L1_Metabolism.L2_Lipid_Metabolism.L3_Arachidonic_acid_metabolism 2.45767391022 0.0074663915324 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Glycine__serine_and_threonine_metabolism 3.93327809881 0.00448395789533 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Phenylalanine__tyrosine_and_tryptophan_biosynthesis 3.93829266004 HC 2.4024236021 2.60653539177e-11 L1_Metabolism.L2_Lipid_Metabolism.L3_Fatty_acid_biosynthesis 3.67874118881 0.00137708442375 L1_Metabolism.L2_Metabolism_of_Cofactors_and_Vitamins.L3_Folate_biosynthesis 3.59445371357 - L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Phenylpropanoid_biosynthesis 3.28474983097 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Nitrotoluene_degradation 3.00717772944 HC 2.05827271182 4.81003652575e-16 L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Isoquinoline_alkaloid_biosynthesis 2.80995405254 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Styrene_degradation 2.33325698593 - L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_1_1_1_Trichloro_2_2_bis_4_chlorophenyl_ethane__DDT__degradation 0.347056915986 0.00268246894805 L1_Genetic_Information_Processing.L2_Replication_and_Repair.L3_Homologous_recombination 3.97970098553 - L1_Organismal_Systems.L2_Immune_System.L3_Fc_gamma_R_mediated_phagocytosis 0.0 - L1_Cellular_Processes.L2_Cell_Motility.L3_Bacterial_chemotaxis 3.59433855536 HC 2.31570890125 0.000855274381787 L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_beta_Alanine_metabolism 3.28594446805 - L1_Unclassified.L2_Genetic_Information_Processing.L3_Protein_folding_and_associated_processing 3.80657208015 CKD 2.21969376771 3.8844709633e-07 L1_Metabolism.L2_Amino_Acid_Metabolism.L3_Valine__leucine_and_isoleucine_biosynthesis 3.87779643203 HC 2.25490088395 1.06140896745e-06 L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_Glutathione_metabolism 3.32961754402 CKD 2.27235120631 3.49392377694e-08 L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Novobiocin_biosynthesis 3.14484428317 1.47193538613e-08 L1_Metabolism.L2_Enzyme_Families.L3_Peptidases 4.28060303712 HC 2.44864476668 0.0152681470604 L1_Unclassified.L2_Genetic_Information_Processing.L3_Restriction_enzyme 3.30891545122 - L1_Metabolism.L2_Lipid_Metabolism.L3_Ether_lipid_metabolism 1.24236184954 - L1_Cellular_Processes.L2_Cell_Motility.L3_Flagellar_assembly 3.46412569629 CKD 2.31291959226 0.0487774090634 L1_Metabolism.L2_Xenobiotics_Biodegradation_and_Metabolism.L3_Caprolactam_degradation 2.50894259339 CKD 2.1278729213 2.65970944045e-20 L1_Metabolism.L2_Metabolism_of_Other_Amino_Acids.L3_Cyanoamino_acid_metabolism 3.51918007485 0.0104814041637 L1_Metabolism.L2_Metabolism_of_Terpenoids_and_Polyketides.L3_Terpenoid_backbone_biosynthesis 3.77188732692 HC 2.32927127421 9.86064751395e-05 L1_Unclassified.L2_Metabolism.L3_Amino_acid_metabolism 3.32863922295 - L1_Human_Diseases.L2_Infectious_Diseases.L3_Amoebiasis 1.93407984577 2.54684162453e-06 L1_Metabolism.L2_Biosynthesis_of_Other_Secondary_Metabolites.L3_Isoflavonoid_biosynthesis 0.0 -