{"text_format":"3","workbook":"xlsx","n_sheets":2,"sheets":["Introduction","MTPM_calculator"],"not_rendered":{"images":4,"macros":1},"read":"whole","date_system":"1900"}

{"sheet":"Introduction","index":0,"n_rows":30,"n_cols":2,"rows_kept":30,"merged":[[1,0,2,8],[4,0,4,8],[5,0,5,8],[7,0,7,8],[8,0,8,8],[9,0,9,8],[12,0,12,8],[17,0,17,8],[22,1,22,8]]}
[]
["Multi Tumor Partition Model (MTPM)"]
[]
[]
["The Multi Tumor Partition Model is a (n+2) compartment partition model, where n is the number of individual tumors. "]
["This method allows to determine: "]
[]
["    1. Mean absorbed dose within the target normal liver by:"]
[]
[]
[]
[]
["    1. Mean absorbed dose within the lungs by:"]
[]
[]
[]
[]
["    3. Mean absorbed dose within  each individual tumor by:"]
[]
[]
[]
[]
[null,"TNRi is the tumor to normal liver activity concentration ratio for individual tumors calculated by "]
[]
[]
[]
[]
["For additional information see:  V.Morán, E.Prieto, L.Sancho, M.Rodríguez-Fraile, L.Soria, JM Martí-Climent."]
["Impact of the dosimetry approach on the resulting 90Y radioembolization planned absorbed doses based"]
["on 99mTc-MAA SPECT-CT. Is there agreement between dosimetry methods?\" EJNMMI Physics. 2020"]

{"sheet":"MTPM_calculator","index":1,"n_rows":102,"n_cols":10,"rows_kept":102,"merged":[[0,4,0,7],[1,9,2,15],[3,1,3,7],[5,1,5,7],[7,9,7,15],[9,9,9,15],[11,9,11,15],[13,9,13,15],[15,1,15,7],[17,9,17,15],[19,9,19,15],[21,9,21,15],[23,1,23,7],[25,9,25,15],[27,9,27,15],[29,9,29,15],[31,9,33,15],[35,9,35,15],[37,9,37,15]]}
[{"$nulls":4},"MULTI-TUMOR PARTITION MODEL FOR 90-Y RADIOEMBOLIZATION TREATMENT PLANNING"]
[{"$nulls":9},"Spreadsheet Instructions"]
[]
[null,"Verónica Morán, Medical Physics Department, Clinica Universidad de Navarra, Madrid (Spain) vmoran@unav.es",{"$nulls":7},"*Brown-shaded cells are prepared to introduce data"]
[{"$nulls":9},"*Red-shaded cells are prepared to show results"]
[null,"Lungs Tissue"]
[]
[null,"90Y Activity GBq",null,null,1.8,{"$nulls":4},"1. Enter 90Y activity in GBq (E8)"]
[]
[null,"LSF (%)",null,null,4.02,{"$nulls":4},"2. Enter lung shunt fraction (LSF) in percentage (E10)"]
[]
[null,"Volume (mL)",null,null,1000,{"$nulls":4},"3. Enter lung tissue volume in mL (E12)"]
[]
[null,"Mean Absorbed Dose (Gy)",null,null,{"$f":"IF(OR(ISBLANK(E12),ISBLANK(E10),ISBLANK(E8)),\"\",(49.67*E8*(E10/100))/(E12/1000))","v":{"v":3.5941211999999996,"d":"3.6"}},{"$nulls":4},"Mean absorbed dose in Gy delivered to the lung tissue is showed in cell E14"]
[]
[null,"Target Healthy Tissue"]
[]
[null,"Volume (mL)",null,null,2277,{"$nulls":4},"4. Enter target healtly tissue volume in mL (E18)"]
[]
[null,"Total uptake (counts)",null,null,545888,{"$nulls":4},"5. Enter total counts registered within target healthy liver volume in 99mTc-MAA SPECT image(E20)"]
[]
[null,"Mean Absorbed Dose (Gy)",null,null,{"$f":"IF(OR(ISBLANK(E8),ISBLANK(E10),ISBLANK(E18),ISBLANK(E28),ISBLANK(E30)),\"\",(49.67*$E$8*(1-$E$10/100))/($E$28*$E$30+E18))*1000","v":{"v":27.26383127610802,"d":"27.3"}},{"$nulls":4},"Mean absorbed dose in Gy delivered to the target healthy tissue is showed in cell E22"]
[]
[null,"Individual Tumors"]
[]
[null,"Number of tumors",null,null,50,{"$nulls":4},"6. Enter number of total individual tumors (E26)"]
[]
[null,"Aggretated tumor volume (mL)",null,null,{"$f":"IF(ISBLANK(D33:D83),\"\",SUMIF(D33:D83,\"<>\"))","v":{"v":734.7763110826663,"d":"735"}},{"$nulls":4},"Aggregated tumor volume in mL is calculated in cell E28"]
[]
[null,"Global TNR",null,null,{"$f":"IF(OR(ISBLANK(E28),SUMIF(G33:G82,\"<>\")=0),\"\",SUMIF(G33:G82,\"<>\")/E28)","v":{"v":1.184662873161875,"d":"1.2"}},{"$nulls":4},"Globar tumor to non-tumor uptake ratio is calculated in cell E30"]
[]
[null,"Tumor ","Location","Volume (mL)","Total uptake (counts)","TNRi","Weight","Absorbed Dose (Gy)",null,"7. Enter each individual tumor location (column C)                                                                                               8. Enter each individual tumor volume in mL (column D)                                                                                     9. Entertotal count registered within each tumor volume in 99mTc-MAA SPECT image(column E)"]
[null,1,null,{"v":185.67876768655609,"d":"186"},{"v":46773.15263977221,"d":"46773"},{"$f":"IF(OR(ISBLANK(E33),ISBLANK(D33),ISBLANK($E$18),ISBLANK($E$20)),\"\",(E33/D33)/($E$20/$E$18))","v":{"v":1.050736651620624,"d":"1.1"}},{"$f":"IF(OR(ISBLANK(F33),ISBLANK(D33)),\"\",(F33*D33))","v":{"v":195.09948663601565,"d":"195"}},{"$f":"IF(OR(ISBLANK($E$8),ISBLANK($E$10),ISBLANK($E$18),ISBLANK($E$28),ISBLANK($E$30),ISBLANK(F33)),\"\",49.67*$E$8*(1-$E$10/100)*F33/($E$28*$E$30+$E$18))*1000","v":{"v":28.647106785407388,"d":"28.6"}}]
[null,2,null,{"v":6.615633052965181,"d":"7"},{"v":1925.568235065652,"d":"1926"},{"$f":"IF(OR(ISBLANK(E34),ISBLANK(D34),ISBLANK($E$18),ISBLANK($E$20)),\"\",(E34/D34)/($E$20/$E$18))","v":{"v":1.2140791135569031,"d":"1.2"}},{"$f":"IF(OR(ISBLANK(F34),ISBLANK(D34)),\"\",(F34*D34))","v":{"v":8.031901912561715,"d":"8"}},{"$f":"IF(OR(ISBLANK($E$8),ISBLANK($E$10),ISBLANK($E$18),ISBLANK($E$28),ISBLANK($E$30),ISBLANK(F34)),\"\",49.67*$E$8*(1-$E$10/100)*F34/($E$28*$E$30+$E$18))*1000","v":{"v":33.1004481078622,"d":"33.1"}}]
[null,3,null,{"v":11.35683674092356,"d":"11"},{"v":4812.649570810264,"d":"4813"},{"v":1.767609554714558,"d":"1.8"},{"v":20.074453134589827,"d":"20"},{"v":48.19180866177415,"d":"48.2"}]
[null,4,null,{"v":9.48240737591676,"d":"9"},{"v":2983.544825390651,"d":"2984"},{"v":1.312421816367944,"d":"1.3"},{"v":12.444918311841462,"d":"12"},{"v":35.78164696453885,"d":"35.8"},null,"Individual tumor to non-tumor uptake ration is calculated in column F"]
[null,5,null,{"v":16.980124835943965,"d":"17"},{"v":4594.16846319309,"d":"4594"},{"v":1.128562253560301,"d":"1.1"},{"$f":"IF(OR(ISBLANK(F37),ISBLANK(D37)),\"\",(F37*D37))","v":{"v":19.16312795058816,"d":"19"}},{"v":30.768930865652287,"d":"30.8"}]
[null,6,null,{"v":4.520682586192873,"d":"5"},{"v":970.8338909406441,"d":"971"},{"v":0.8957780104138632,"d":"0.9"},{"v":4.049528052772449,"d":"4"},{"v":24.4223405367713,"d":"24.4"},null,"Mean absorbed dose in Gy delivered to each individual tumor is showed in column H"]
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