Category ID Description GeneRatio BgRatio pvalue padj geneID Count KEGG hsa04080 Neuroactive ligand-receptor interaction 83/558 154/2131 2.56191624892027e-14 4.63706841054569e-12 MC3R/GRM4/KISS1R/SSTR2/GIPR/TACR3/GABRA1/DRD2/GABRA4/CNR1/GHRHR/MLNR/GRM8/GABBR2/CHRNB2/GRIN1/HTR5A/TSHR/GRID2/VIPR1/GRM7/HTR1A/GRIK4/CRHR1/CHRNA3/CHRNA5/TRHR/FSHB/GABRA3/CHRND/GABRG3/MCHR1/GABRQ/CALCR/FSHR/ADCYAP1R1/GABRG1/TAAR2/OPRD1/TAAR5/TAAR1/CSH1/PLG/CGA/GRIN2C/GRM3/GLRB/SSTR3/GRIK5/GRIA3/GRM1/GRIA2/GABRB2/GRIK2/CHRM4/HRH3/ADRB1/F2/PRLR/DRD1/GLRA2/GH1/BRS3/GRIN2A/GABRB1/SSTR1/AVPR1B/GRIA1/GPR83/GABRA2/THRA/P2RX6/GLRA1/GABRB3/GABRG2/GABRP/HTR1B/HTR4/NMUR2/HCRTR1/GABBR1/GRIK3/NTSR1 83 KEGG hsa04740 Olfactory transduction 78/558 181/2131 1.79583156639722e-07 1.62522756758949e-05 OR13C2/OR4A5/OR13A1/OR5AU1/OR3A1/OR3A3/OR10G3/OR3A2/OR1C1/OR4F15/OR4D9/OR4B1/OR1E1/OR4A16/OR2W3/OR2T33/OR7A5/OR2T1/OR14I1/OR51A2/OR52E8/OR51G2/OR2B2/OR51E1/OR51S1/OR51E2/OR51D1/OR56A4/CALML3/OR2B6/OR52L1/OR1G1/OR51A4/OR1J2/OR11H4/OR4F17/CNGA3/CAMK2B/OR2M3/OR56A3/OR13C4/OR13C3/OR10H5/OR8D2/OR51V1/OR10H2/OR8G1/OR51L1/OR13F1/OR52R1/OR10H3/OR6F1/OR51Q1/OR13G1/OR4N5/OR52J3/OR13C9/OR1Q1/OR13J1/CALM1/CALM2/OR51A7/OR51F2/OR10G8/OR7C1/OR2A7/CLCA4/OR5V1/OR2AE1/OR10G2/OR6N1/OR6N2/OR1S2/OR56B4/OR51G1/OR51T1/OR4F6/OR2W1 78 KEGG hsa04720 Long-term potentiation 17/558 31/2131 0.000599464255682481 0.0361676767595097 PLCB4/PPP1R1A/RPS6KA6/GRIN1/ADCY1/CALML3/GRIN2C/CAMK2B/GRM1/GRIA2/PRKCG/GRIN2A/GRIA1/CALM1/CALM2/ADCY8/CACNA1C 17 KEGG hsa04742 Taste transduction 15/558 30/2131 0.00419175723643363 0.16153118827684 TAS2R13/TAS2R14/CACNA1A/GRM4/KCNB1/ASIC2/CACNA1B/GNAS/TAS2R10/TAS2R50/TAS2R8/TAS2R9/TAS2R19/ADCY8/GNAT3 15 KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 7/558 10/2131 0.00456695638852334 0.16153118827684 EXTL3/NDST4/HS6ST3/B3GAT2/HS3ST5/NDST3/B3GAT1 7 KEGG hsa04950 Maturity onset diabetes of the young 6/558 8/2131 0.00535462502575161 0.16153118827684 GCK/PKLR/NKX6-1/PAX6/NKX2-2/NEUROD1 6 KEGG hsa04260 Cardiac muscle contraction 17/558 38/2131 0.00969325933975503 0.228301637276617 CACNG5/CACNG7/CACNG2/ATP1A3/ATP1B1/COX1/COX7B2/CACNA2D2/CACNA2D3/CACNA2D1/ATP1B4/CACNG6/CACNG8/COX6C/CACNA1D/COX3/CACNA1C 17 KEGG hsa04972 Pancreatic secretion 21/558 50/2131 0.010090680100624 0.228301637276617 PLCB4/ATP1A3/ATP1B1/ADCY1/ATP2B2/ADCY2/GNAS/PRKCG/ATP1B4/CPB2/ATP2A3/KCNMA1/CPA2/CELA3A/CELA2B/PNLIPRP1/PNLIP/AMY2A/ADCY8/CLCA4/PLA2G12A 21 KEGG hsa04020 Calcium signaling pathway 34/558 92/2131 0.0131613953759351 0.264690284782694 PLCB4/PHKA1/CACNA1A/TACR3/GRIN1/HTR5A/ADCY1/TRHR/ATP2B2/CACNA1E/CALML3/ADCY2/GRIN2C/CACNA1B/CAMK2B/GNAS/GRM1/ADRB1/PRKCG/DRD1/GRIN2A/ATP2A3/CACNA1D/CACNA1H/SLC25A4/AVPR1B/SLC8A3/P2RX6/CALM1/CALM2/ADCY8/HTR4/NTSR1/CACNA1C 34 KEGG hsa04730 Long-term depression 15/558 34/2131 0.0171129939562398 0.285698281485874 PLCB4/CACNA1A/PPP1R17/GRID2/GNAZ/CRHR1/GNAS/GRIA3/GRM1/GRIA2/PRKCG/GNAO1/GRIA1/IGF1R/PLA2G12A 15 KEGG hsa04971 Gastric acid secretion 18/558 43/2131 0.0173628789853294 0.285698281485874 PLCB4/SSTR2/ATP1A3/ATP1B1/ADCY1/SST/GAST/CALML3/KCNE2/ADCY2/CAMK2B/GNAS/KCNK2/PRKCG/ATP1B4/CALM1/CALM2/ADCY8 18 KEGG hsa05014 Amyotrophic lateral sclerosis (ALS) 10/558 21/2131 0.0276216732500913 0.416626904855544 GRIN1/NEFM/NEFL/GRIN2C/GRIA2/PRPH/GRIN2A/GRIA1/CASP9/CYCS 10 KEGG hsa04976 Bile secretion 14/558 33/2131 0.0302850525283171 0.421661115971184 UGT2B4/ATP1A3/ATP1B1/ADCY1/KCNN2/SLC22A8/SLC9A3/ADCY2/GNAS/SLC5A1/ATP1B4/ABCG8/SLC10A2/ADCY8 14 KEGG hsa04970 Salivary secretion 20/558 52/2131 0.0335422486109654 0.433653357041768 PLCB4/ATP1A3/ATP1B1/ADCY1/ATP2B2/HTN1/CALML3/ADCY2/GNAS/ADRB1/PRKCG/ATP1B4/VAMP2/KCNMA1/PRB2/AMY1C/CALM1/CALM2/ADCY8/BEST2 20 KEGG hsa04930 Type II diabetes mellitus 10/558 23/2131 0.0534990734897623 0.645555486776464 GCK/CACNA1A/MAPK10/PKLR/CACNA1E/CACNA1B/ABCC8/CACNA1D/KCNJ11/CACNA1C 10 KEGG hsa04912 GnRH signaling pathway 16/558 42/2131 0.0589821776913339 0.667235885133214 PLCB4/MAPK10/ADCY1/FSHB/CGA/CALML3/ADCY2/CAMK2B/GNAS/GNRH2/CACNA1D/CALM1/CALM2/ADCY8/CACNA1C/PLA2G12A 16 KEGG hsa00380 Tryptophan metabolism 6/558 12/2131 0.0660948107428646 0.703715337909323 ACMSD/OGDHL/TPH2/TPH1/DDC/MAOB 6 KEGG hsa04973 Carbohydrate digestion and absorption 9/558 21/2131 0.0717736782867364 0.721724209438849 ATP1A3/ATP1B1/SLC5A1/ATP1B4/CACNA1D/AKT3/AMY1C/AMY2A/GNAT3 9 KEGG hsa04916 Melanogenesis 18/558 50/2131 0.0786965705884297 0.739137630975584 PLCB4/POMC/ADCY1/CALML3/ADCY2/CAMK2B/GNAS/WNT4/WNT16/PRKCG/WNT3A/GNAO1/CALM1/CALM2/ADCY8/WNT1/FZD10/WNT2 18 KEGG hsa00790 Folate biosynthesis 4/558 7/2131 0.0816726664061418 0.739137630975584 QDPR/GCH1/ALPP/ALPPL2 4 KEGG hsa00650 Butanoate metabolism 5/558 10/2131 0.0922337348026021 0.763711470230228 GAD1/BDH1/ACSM4/GAD2/OXCT1 5 KEGG hsa05010 Alzheimer's disease 21/558 61/2131 0.0928268085362708 0.763711470230228 PLCB4/GRIN1/COX1/COX7B2/CALML3/GRIN2C/MAPT/APBB1/NDUFA5/GRIN2A/ATP2A3/COX6C/CACNA1D/COX3/CASP9/CALM1/CALM2/NDUFA7/NDUFA1/CYCS/CACNA1C 21 KEGG hsa03015 mRNA surveillance pathway 10/558 26/2131 0.115644861287727 0.910074777959935 PABPC1L2A/NXF2/MSI1/PABPC1L2B/NXF2B/PABPC5/NXF5/PPP2R2C/RNMT/PPP2R2B 10 KEGG hsa00910 Nitrogen metabolism 4/558 8/2131 0.130451092137787 0.979721980921027 HAL/CA5A/CA8/CA6 4 KEGG hsa05218 Melanoma 11/558 30/2131 0.135320715596827 0.979721980921027 CCND1/FGF17/FGF12/FGF22/FGF13/E2F2/AKT3/IGF1R/FGF14/FGF9/FGF3 11 KEGG hsa05214 Glioma 9/558 24/2131 0.15048002829948 0.999999955783023 CCND1/CALML3/CAMK2B/PRKCG/E2F2/AKT3/IGF1R/CALM1/CALM2 9 KEGG hsa00230 Purine metabolism 19/558 58/2131 0.157730970977055 0.999999955783023 ADSSL1/AK7/NME5/ADCY1/PKLR/ENTPD8/PDE11A/ADCY2/PDE10A/PDE9A/GUCY2C/ADCY10/NT5M/NTPCR/ADCY8/ALLC/HPRT1/PDE4C/PDE6H 19 KEGG hsa05016 Huntington's disease 19/558 58/2131 0.157730970977055 0.999999955783023 PLCB4/DNAI1/DNALI1/DNAL1/PPARGC1A/GRIN1/COX1/COX7B2/DLG4/GRM1/NDUFA5/DNAI2/COX6C/SLC25A4/COX3/CASP9/NDUFA7/NDUFA1/CYCS 19 KEGG hsa04540 Gap junction 13/558 38/2131 0.170298630708583 0.999999955783023 PLCB4/GJD2/DRD2/TUBA8/ADCY1/TUBB1/ADCY2/GNAS/GRM1/ADRB1/PRKCG/DRD1/ADCY8 13 KEGG hsa04744 Phototransduction 5/558 12/2131 0.182470100960311 0.999999955783023 RGS9/CALML3/CALM1/CALM2/GNAT3 5 KEGG hsa04964 Proximal tubule bicarbonate reclamation 5/558 12/2131 0.182470100960311 0.999999955783023 PCK1/ATP1A3/ATP1B1/SLC9A3/ATP1B4 5 KEGG hsa03320 PPAR signaling pathway 9/558 25/2131 0.183541254855025 0.999999955783023 FABP2/PCK1/ACSL6/FABP7/RXRG/FABP6/APOC3/FABP1/APOA2 9 KEGG hsa05216 Thyroid cancer 3/558 7/2131 0.268349020016977 0.999999955783023 CCND1/RET/RXRG 3 KEGG hsa04270 Vascular smooth muscle contraction 16/558 52/2131 0.268754443446654 0.999999955783023 PLCB4/ADCY1/CALML3/ADCY2/KCNMB2/GNAS/KCNU1/PRKCG/CACNA1D/KCNMA1/AVPR1B/CALM1/CALM2/ADCY8/CACNA1C/PLA2G12A 16 KEGG hsa04310 Wnt signaling pathway 17/558 56/2131 0.280611575341406 0.999999955783023 CER1/PLCB4/MAPK10/CCND1/DKK4/APC2/CAMK2B/WNT4/WNT16/PRKCG/NKD2/WNT3A/CXXC4/TBL1X/WNT1/FZD10/WNT2 17 KEGG hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 5/558 14/2131 0.293593752532396 0.999999955783023 B3GALT2/B4GAT1/ST3GAL6/FUT2/FUT3 5 KEGG hsa04962 Vasopressin-regulated water reabsorption 5/558 14/2131 0.293593752532396 0.999999955783023 DYNC1I1/GNAS/VAMP2/DYNLL2/NSF 5 KEGG hsa05012 Parkinson's disease 12/558 39/2131 0.310414476002591 0.999999955783023 COX1/COX7B2/SLC18A1/UCHL1/NDUFA5/COX6C/SLC25A4/COX3/CASP9/NDUFA7/NDUFA1/CYCS 12 KEGG hsa05414 Dilated cardiomyopathy 15/558 50/2131 0.316618449686482 0.999999955783023 CACNG5/CACNG7/CACNG2/ADCY1/CACNA2D2/CACNA2D3/CACNA2D1/ADCY2/GNAS/ADRB1/CACNG6/CACNG8/CACNA1D/ADCY8/CACNA1C 15 KEGG hsa00260 Glycine, serine and threonine metabolism 4/558 11/2131 0.319536665701979 0.999999955783023 PIPOX/GCAT/GATM/MAOB 4 KEGG hsa04150 mTOR signaling pathway 4/558 11/2131 0.319536665701979 0.999999955783023 RPS6KA6/EIF4E1B/RPTOR/AKT3 4 KEGG hsa04966 Collecting duct acid secretion 4/558 11/2131 0.319536665701979 0.999999955783023 ATP6V0E2/ATP6V1G2/CLCNKB/ATP6V1C2 4 KEGG hsa04975 Fat digestion and absorption 8/558 25/2131 0.321178500167814 0.999999955783023 FABP2/LIPF/APOB/ABCG8/PNLIPRP1/PNLIP/FABP1/PLA2G12A 8 KEGG hsa05223 Non-small cell lung cancer 6/558 18/2131 0.323794418560835 0.999999955783023 CCND1/RXRG/PRKCG/E2F2/AKT3/CASP9 6 KEGG hsa04974 Protein digestion and absorption 12/558 40/2131 0.346077474486529 0.999999955783023 MEP1B/ATP1A3/ATP1B1/SLC9A3/ATP1B4/COL2A1/CPB2/SLC8A3/SLC7A8/CPA2/CELA3A/CELA2B 12 KEGG hsa00020 Citrate cycle (TCA cycle) 4/558 12/2131 0.388069948072812 0.999999955783023 PCK1/OGDHL/SUCLA2/FH 4 KEGG hsa03013 RNA transport 8/558 27/2131 0.412063047434868 0.999999955783023 PABPC1L2A/NXF2/PABPC1L2B/NXF2B/EIF4E1B/PABPC5/NXF5/EEF1A2 8 KEGG hsa00860 Porphyrin and chlorophyll metabolism 5/558 16/2131 0.412701094227747 0.999999955783023 UGT2B4/UGT2B11/CP/MMAB/UGT2B10 5 KEGG hsa04010 MAPK signaling pathway 31/558 113/2131 0.41480177503398 0.999999955783023 CACNG5/CACNG7/CACNA1A/RPS6KA6/MAPK10/CACNG2/RASGRF1/MAPK8IP1/FGF17/FGF12/CACNA2D2/FGF22/CACNA1E/MAPK8IP2/CACNA2D3/CACNA2D1/MAPT/CACNA1B/PRKCG/CACNG6/FGF13/CACNG8/CACNA1D/CACNA1H/AKT3/FGF14/FGF9/FGF3/NTF4/CACNA1C/PLA2G12A 31 KEGG hsa04920 Adipocytokine signaling pathway 9/558 31/2131 0.425275311142137 0.999999955783023 CAMKK1/PCK1/MAPK10/PPARGC1A/ACSL6/POMC/RXRG/AKT3/AGRP 9 KEGG hsa03008 Ribosome biogenesis in eukaryotes 3/558 9/2131 0.432566420518235 0.999999955783023 NXF2/NXF2B/NXF5 3 KEGG hsa04130 SNARE interactions in vesicular transport 3/558 9/2131 0.432566420518235 0.999999955783023 VAMP4/VAMP2/SNAP25 3 KEGG hsa04140 Regulation of autophagy 3/558 9/2131 0.432566420518235 0.999999955783023 GABARAPL2/IFNA13/IFNA2 3 KEGG hsa04977 Vitamin digestion and absorption 3/558 9/2131 0.432566420518235 0.999999955783023 APOB/PNLIP/SLC46A1 3 KEGG hsa04340 Hedgehog signaling pathway 7/558 24/2131 0.445556607583682 0.999999955783023 LRP2/WNT4/WNT16/WNT3A/WNT1/IHH/WNT2 7 KEGG hsa00620 Pyruvate metabolism 4/558 13/2131 0.455557496860199 0.999999955783023 PCK1/PKLR/ACOT12/HAGH 4 KEGG hsa04115 p53 signaling pathway 8/558 28/2131 0.457618647058883 0.999999955783023 TP53AIP1/CCND1/CCNE2/RPRM/ADGRB1/CASP9/TP73/CYCS 8 KEGG hsa04910 Insulin signaling pathway 13/558 47/2131 0.464026601881795 0.999999955783023 PHKA1/GCK/PCK1/MAPK10/PPARGC1A/PKLR/EIF4E1B/CALML3/RPTOR/PRKAR1A/AKT3/CALM1/CALM2 13 KEGG hsa02010 ABC transporters 5/558 17/2131 0.471556456023905 0.999999955783023 ABCG4/ABCA2/ABCA3/ABCG8/ABCC8 5 KEGG hsa05210 Colorectal cancer 6/558 21/2131 0.483867599242075 0.999999955783023 MAPK10/CCND1/APC2/AKT3/CASP9/CYCS 6 KEGG hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 2/558 6/2131 0.494116131128541 0.999999955783023 TAT/COQ3 2 KEGG hsa00360 Phenylalanine metabolism 3/558 10/2131 0.509925604114647 0.999999955783023 TAT/DDC/MAOB 3 KEGG hsa01100 Metabolic pathways 96/558 366/2131 0.514824292105295 0.999999955783023 PLCB4/IDS/RPEL1/GCK/OCRL/UGT2B4/CDO1/ADSSL1/PIPOX/PCK1/ST8SIA5/TAT/ALOX12B/AK7/GALNTL6/ACMSD/NME5/OGDHL/LIPF/MGAT4C/TPH2/COX1/ACSL6/ATP6V0E2/PKLR/UGT2B11/GAD1/PFKM/COX7B2/ATP6V1G2/GPAT2/HAL/TPH1/DDC/EXTL3/B3GALT2/NDST4/B4GALT6/B4GAT1/PDXP/NDUFA5/DGKB/B3GAT2/PON3/BDH1/ACSM4/HAO1/ATP6V1C2/QDPR/SMPD3/COX6C/CDS2/ST3GAL6/PIGH/ETNK2/NT5M/CKB/NTPCR/ENO2/GAD2/GCH1/COX3/PGK2/NDST3/SUCLA2/ADH1C/FH/COQ3/AMY1C/GATM/PNLIPRP1/PNLIP/AMY2A/PON1/PEMT/GALNT18/ALLC/GCNT3/MMAB/NDUFA7/HPRT1/NDUFA1/HSD11B2/DHRS9/ALPP/ALPPL2/DPM3/LPCAT4/FUT2/FUT3/UGT2B10/CYP2A13/GALNT9/B3GAT1/MAOB/PLA2G12A 96 KEGG hsa04610 Complement and coagulation cascades 10/558 37/2131 0.516601515341844 0.999999955783023 SERPIND1/F10/PLG/F2/C8B/F13B/CPB2/F5/FGB/PROC 10 KEGG hsa00053 Ascorbate and aldarate metabolism 4/558 14/2131 0.520342994591321 0.999999955783023 UGT2B4/UGT2B11/UGT2B10/MIOX 4 KEGG hsa00561 Glycerolipid metabolism 5/558 18/2131 0.528388008894316 0.999999955783023 LIPF/GPAT2/DGKB/PNLIPRP1/PNLIP 5 KEGG hsa04960 Aldosterone-regulated sodium reabsorption 5/558 18/2131 0.528388008894316 0.999999955783023 ATP1A3/ATP1B1/PRKCG/ATP1B4/HSD11B2 5 KEGG hsa05110 Vibrio cholerae infection 5/558 18/2131 0.528388008894316 0.999999955783023 ATP6V0E2/ATP6V1G2/GNAS/PRKCG/ATP6V1C2 5 KEGG hsa00040 Pentose and glucuronate interconversions 4/558 15/2131 0.581219718143191 0.999999955783023 RPEL1/UGT2B4/UGT2B11/UGT2B10 4 KEGG hsa04146 Peroxisome 4/558 15/2131 0.581219718143191 0.999999955783023 PIPOX/ACSL6/HAO1/PXMP4 4 KEGG hsa00250 Alanine, aspartate and glutamate metabolism 3/558 11/2131 0.581321456019398 0.999999955783023 ADSSL1/GAD1/GAD2 3 KEGG hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 2/558 7/2131 0.584422975573166 0.999999955783023 B3GAT2/B3GAT1 2 KEGG hsa04614 Renin-angiotensin system 2/558 7/2131 0.584422975573166 0.999999955783023 REN/AGT 2 KEGG hsa04710 Circadian rhythm 2/558 7/2131 0.584422975573166 0.999999955783023 PER3/CRY2 2 KEGG hsa05217 Basal cell carcinoma 7/558 27/2131 0.586017642006425 0.999999955783023 APC2/WNT4/WNT16/WNT3A/WNT1/FZD10/WNT2 7 KEGG hsa00564 Glycerophospholipid metabolism 8/558 31/2131 0.588166607759946 0.999999955783023 GPAT2/DGKB/CDS2/ETNK2/PEMT/LPCAT4/CHAT/PLA2G12A 8 KEGG hsa04070 Phosphatidylinositol signaling system 8/558 31/2131 0.588166607759946 0.999999955783023 PLCB4/OCRL/CALML3/DGKB/PRKCG/CDS2/CALM1/CALM2 8 KEGG hsa04914 Progesterone-mediated oocyte maturation 8/558 31/2131 0.588166607759946 0.999999955783023 CCNA1/RPS6KA6/MAPK10/ADCY1/ADCY2/AKT3/IGF1R/ADCY8 8 KEGG hsa00190 Oxidative phosphorylation 10/558 40/2131 0.628550912231289 0.999999955783023 COX1/ATP6V0E2/COX7B2/ATP6V1G2/NDUFA5/ATP6V1C2/COX6C/COX3/NDUFA7/NDUFA1 10 KEGG hsa04722 Neurotrophin signaling pathway 10/558 40/2131 0.628550912231289 0.999999955783023 RPS6KA6/MAPK10/CALML3/NGFRAP1/CAMK2B/AKT3/CALM1/CALM2/TP73/NTF4 10 KEGG hsa00600 Sphingolipid metabolism 4/558 16/2131 0.637392592781672 0.999999955783023 NEU2/CERK/B4GALT6/SMPD3 4 KEGG hsa04360 Axon guidance 13/558 53/2131 0.661167871479197 0.999999955783023 EFNB3/EPHA7/ROBO2/UNC5D/DPYSL5/EPHA6/EPHA5/SLIT1/SEMA3E/PAK4/NTNG1/SRGAP3/EPHA4 13 KEGG hsa04114 Oocyte meiosis 11/558 45/2131 0.661849356346838 0.999999955783023 RPS6KA6/ADCY1/CCNE2/CALML3/FBXO43/ADCY2/CAMK2B/IGF1R/CALM1/CALM2/ADCY8 11 KEGG hsa04320 Dorso-ventral axis formation 2/558 8/2131 0.662201375182724 0.999999955783023 FMN2/PIWIL3 2 KEGG hsa00010 Glycolysis / Gluconeogenesis 7/558 29/2131 0.669017502412795 0.999999955783023 GCK/PCK1/PKLR/PFKM/ENO2/PGK2/ADH1C 7 KEGG hsa05215 Prostate cancer 6/558 25/2131 0.673212211949448 0.999999955783023 CCND1/CCNE2/E2F2/AKT3/CASP9/IGF1R 6 KEGG hsa00512 Mucin type O-Glycan biosynthesis 4/558 17/2131 0.688419096399447 0.999999955783023 GALNTL6/GALNT18/GCNT3/GALNT9 4 KEGG hsa03018 RNA degradation 4/558 17/2131 0.688419096399447 0.999999955783023 PABPC1L2A/PABPC1L2B/PABPC5/ENO2 4 KEGG hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 10/558 42/2131 0.695016535516938 0.999999955783023 CACNG5/CACNG7/CACNG2/CACNA2D2/CACNA2D3/CACNA2D1/CACNG6/CACNG8/CACNA1D/CACNA1C 10 KEGG hsa05222 Small cell lung cancer 9/558 38/2131 0.697849956000305 0.999999955783023 PIAS2/CCND1/CCNE2/RXRG/E2F2/SKP2/AKT3/CASP9/CYCS 9 KEGG hsa00340 Histidine metabolism 3/558 13/2131 0.702792963877344 0.999999955783023 HAL/DDC/MAOB 3 KEGG hsa05219 Bladder cancer 3/558 13/2131 0.702792963877344 0.999999955783023 CCND1/E2F2/DAPK1 3 KEGG hsa00500 Starch and sucrose metabolism 6/558 26/2131 0.712900384732364 0.999999955783023 GCK/UGT2B4/UGT2B11/AMY1C/AMY2A/UGT2B10 6 KEGG hsa00051 Fructose and mannose metabolism 2/558 9/2131 0.72781136222972 0.999999955783023 MTMR7/PFKM 2 KEGG hsa00510 N-Glycan biosynthesis 2/558 9/2131 0.72781136222972 0.999999955783023 MGAT4C/DPM3 2 KEGG hsa05213 Endometrial cancer 4/558 18/2131 0.734142264258055 0.999999955783023 CCND1/APC2/AKT3/CASP9 4 KEGG hsa00830 Retinol metabolism 6/558 27/2131 0.749152596939776 0.999999955783023 UGT2B4/UGT2B11/ADH1C/DHRS9/UGT2B10/CYP2A13 6 KEGG hsa00982 Drug metabolism - cytochrome P450 6/558 27/2131 0.749152596939776 0.999999955783023 UGT2B4/UGT2B11/ADH1C/UGT2B10/CYP2A13/MAOB 6 KEGG hsa05410 Hypertrophic cardiomyopathy (HCM) 10/558 44/2131 0.753625435714251 0.999999955783023 CACNG5/CACNG7/CACNG2/CACNA2D2/CACNA2D3/CACNA2D1/CACNG6/CACNG8/CACNA1D/CACNA1C 10 KEGG hsa00350 Tyrosine metabolism 4/558 19/2131 0.774624470803197 0.999999955783023 TAT/DDC/ADH1C/MAOB 4 KEGG hsa00270 Cysteine and methionine metabolism 2/558 10/2131 0.782282801758489 0.999999955783023 CDO1/TAT 2 KEGG hsa00140 Steroid hormone biosynthesis 5/558 24/2131 0.794128366569083 0.999999955783023 UGT2B4/UGT2B11/SULT1E1/HSD11B2/UGT2B10 5 KEGG hsa00983 Drug metabolism - other enzymes 5/558 24/2131 0.794128366569083 0.999999955783023 UGT2B4/UGT2B11/HPRT1/UGT2B10/CYP2A13 5 KEGG hsa05120 Epithelial cell signaling in Helicobacter pylori infection 5/558 24/2131 0.794128366569083 0.999999955783023 MAPK10/ATP6V0E2/ATP6V1G2/PTPRZ1/ATP6V1C2 5 KEGG hsa05211 Renal cell carcinoma 4/558 20/2131 0.81008713291699 0.999999955783023 ARNT2/PAK4/FH/AKT3 4 KEGG hsa04012 ErbB signaling pathway 6/558 29/2131 0.811437523676944 0.999999955783023 MAPK10/NRG1/CAMK2B/PRKCG/PAK4/AKT3 6 KEGG hsa04940 Type I diabetes mellitus 5/558 25/2131 0.824357405223992 0.999999955783023 PTPRN/GAD1/PTPRN2/GAD2/CPE 5 KEGG hsa05160 Hepatitis C 7/558 34/2131 0.826893963367697 0.999999955783023 PIAS2/MAPK10/AKT3/PPP2R2C/IFNA13/IFNA2/PPP2R2B 7 KEGG hsa00052 Galactose metabolism 2/558 11/2131 0.826940878589398 0.999999955783023 GCK/PFKM 2 KEGG hsa00071 Fatty acid degradation 2/558 11/2131 0.826940878589398 0.999999955783023 ACSL6/ADH1C 2 KEGG hsa00310 Lysine degradation 2/558 11/2131 0.826940878589398 0.999999955783023 PIPOX/OGDHL 2 KEGG hsa00562 Inositol phosphate metabolism 3/558 16/2131 0.831844944406164 0.999999955783023 PLCB4/OCRL/MIOX 3 KEGG hsa00640 Propanoate metabolism 1/558 6/2131 0.838644038569884 0.999999955783023 SUCLA2 1 KEGG hsa05200 Pathways in cancer 31/558 136/2131 0.84886549729504 0.999999955783023 CCNA1/PIAS2/MAPK10/CCND1/FGF17/FGF12/FGF22/APC2/CCNE2/RET/RXRG/WNT4/WNT16/PRKCG/FGF13/WNT3A/E2F2/SKP2/ARNT2/FH/AKT3/CASP9/IGF1R/DAPK1/FGF14/FGF9/WNT1/FGF3/CYCS/FZD10/WNT2 31 KEGG hsa05212 Pancreatic cancer 5/558 26/2131 0.850894791055332 0.999999955783023 MAPK10/CCND1/E2F2/AKT3/CASP9 5 KEGG hsa05320 Autoimmune thyroid disease 5/558 26/2131 0.850894791055332 0.999999955783023 TSHR/IL4/CGA/IFNA13/IFNA2 5 KEGG hsa00565 Ether lipid metabolism 3/558 17/2131 0.862579054693318 0.999999955783023 ENPP2/LPCAT4/PLA2G12A 3 KEGG hsa00030 Pentose phosphate pathway 2/558 12/2131 0.863181329240292 0.999999955783023 RPEL1/PFKM 2 KEGG hsa05020 Prion diseases 2/558 12/2131 0.863181329240292 0.999999955783023 C8B/NCAM1 2 KEGG hsa00514 Other types of O-glycan biosynthesis 4/558 22/2131 0.867333360748241 0.999999955783023 UGT2B4/UGT2B11/POMT1/UGT2B10 4 KEGG hsa03050 Proteasome 1/558 7/2131 0.881014215736004 0.999999955783023 PSMB11 1 KEGG hsa03420 Nucleotide excision repair 1/558 7/2131 0.881014215736004 0.999999955783023 CETN2 1 KEGG hsa04530 Tight junction 10/558 50/2131 0.881192485986207 0.999999955783023 MAGI2/MYH2/MYH4/MYH8/RAB3B/PRKCG/MYH7B/AKT3/PPP2R2C/PPP2R2B 10 KEGG hsa05416 Viral myocarditis 7/558 38/2131 0.904709774086148 0.999999955783023 CCND1/MYH2/MYH4/MYH8/MYH7B/CASP9/CYCS 7 KEGG hsa05221 Acute myeloid leukemia 3/558 19/2131 0.90957427690109 0.999999955783023 CCNA1/CCND1/AKT3 3 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 5/558 29/2131 0.911234554852093 0.999999955783023 UGT2B4/CYP2F1/UGT2B11/ADH1C/UGT2B10 5 KEGG hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 1/558 8/2131 0.912273192957901 0.999999955783023 B4GAT1 1 KEGG hsa00592 alpha-Linolenic acid metabolism 1/558 8/2131 0.912273192957901 0.999999955783023 PLA2G12A 1 KEGG hsa00760 Nicotinate and nicotinamide metabolism 1/558 8/2131 0.912273192957901 0.999999955783023 NT5M 1 KEGG hsa04622 RIG-I-like receptor signaling pathway 3/558 20/2131 0.927130831721814 0.999999955783023 MAPK10/IFNA13/IFNA2 3 KEGG hsa04144 Endocytosis 12/558 63/2131 0.93102860493211 0.999999955783023 DNM3/DNAJC6/GRK4/RET/IQSEC3/ADRB1/SH3GL3/PSD/SH3GL2/IGF1R/VPS37D/KDR 12 KEGG hsa05142 Chagas disease (American trypanosomiasis) 8/558 45/2131 0.934088666253927 0.999999955783023 PLCB4/MAPK10/ADCY1/GNAS/GNAO1/AKT3/PPP2R2C/PPP2R2B 8 KEGG hsa00280 Valine, leucine and isoleucine degradation 1/558 9/2131 0.935330921798924 0.999999955783023 OXCT1 1 KEGG hsa00330 Arginine and proline metabolism 3/558 21/2131 0.941509482861898 0.999999955783023 CKB/GATM/MAOB 3 KEGG hsa04370 VEGF signaling pathway 5/558 32/2131 0.949023439549664 0.999999955783023 PRKCG/AKT3/CASP9/KDR/PLA2G12A 5 KEGG hsa04666 Fc gamma R-mediated phagocytosis 6/558 37/2131 0.949365311400486 0.999999955783023 AMPH/DNM3/WASF3/PRKCG/SCIN/AKT3 6 KEGG hsa04141 Protein processing in endoplasmic reticulum 3/558 22/2131 0.953221502143002 0.999999955783023 MAPK10/HSPA4L/PRKCSH 3 KEGG hsa05220 Chronic myeloid leukemia 3/558 23/2131 0.96271440198137 0.999999955783023 CCND1/E2F2/AKT3 3 KEGG hsa04514 Cell adhesion molecules (CAMs) 11/558 64/2131 0.96922045628642 0.999999955783023 CNTNAP2/CNTN1/NLGN1/CDH4/CNTN2/NCAM1/NFASC/NRXN1/CADM1/NLGN4X/NLGN3 11 KEGG hsa00520 Amino sugar and nucleotide sugar metabolism 2/558 18/2131 0.96924396113843 0.999999955783023 CHIA/GCK 2 KEGG hsa04330 Notch signaling pathway 2/558 18/2131 0.96924396113843 0.999999955783023 DLL3/HES5 2 KEGG hsa04210 Apoptosis 5/558 35/2131 0.971611671911176 0.999999955783023 PRKAR1A/AKT3/CASP9/CYCS/ENDOG 5 KEGG hsa04630 Jak-STAT signaling pathway 11/558 65/2131 0.97362862544122 0.999999955783023 IL23R/PIAS2/CCND1/IL4/CSH1/PRLR/GH1/IL13RA2/AKT3/IFNA13/IFNA2 11 KEGG hsa04621 NOD-like receptor signaling pathway 2/558 19/2131 0.976263923989882 0.999999955783023 MAPK10/PYDC1 2 KEGG hsa04142 Lysosome 3/558 25/2131 0.976528983698883 0.999999955783023 IDS/ABCA2/AP3B2 3 KEGG hsa04620 Toll-like receptor signaling pathway 4/558 31/2131 0.97853742152616 0.999999955783023 MAPK10/AKT3/IFNA13/IFNA2 4 KEGG hsa00240 Pyrimidine metabolism 3/558 26/2131 0.981456063936822 0.999999955783023 NME5/ENTPD8/NT5M 3 KEGG hsa00590 Arachidonic acid metabolism 2/558 20/2131 0.981723156464112 0.999999955783023 ALOX12B/PLA2G12A 2 KEGG hsa04623 Cytosolic DNA-sensing pathway 2/558 20/2131 0.981723156464112 0.999999955783023 IFNA13/IFNA2 2 KEGG hsa05130 Pathogenic Escherichia coli infection 2/558 20/2131 0.981723156464112 0.999999955783023 TUBA8/TUBB1 2 KEGG hsa04664 Fc epsilon RI signaling pathway 4/558 32/2131 0.982753704665659 0.999999955783023 MAPK10/IL4/AKT3/PLA2G12A 4 KEGG hsa05143 African trypanosomiasis 2/558 21/2131 0.985956174738029 0.999999955783023 PLCB4/PRKCG 2 KEGG hsa00591 Linoleic acid metabolism 1/558 14/2131 0.985958221865707 0.999999955783023 PLA2G12A 1 KEGG hsa04120 Ubiquitin mediated proteolysis 3/558 28/2131 0.988511492348817 0.999999955783023 UBE2QL1/PIAS2/SKP2 3 KEGG hsa04672 Intestinal immune network for IgA production 2/558 23/2131 0.991754902951452 0.999999955783023 IL4/CCL27 2 KEGG hsa05310 Asthma 1/558 16/2131 0.992386240509249 0.999999955783023 IL4 1 KEGG hsa04350 TGF-beta signaling pathway 3/558 30/2131 0.992947037835521 0.999999955783023 FST/BMPR1B/AMH 3 KEGG hsa04520 Adherens junction 3/558 30/2131 0.992947037835521 0.999999955783023 SSX2IP/WASF3/IGF1R 3 KEGG hsa05340 Primary immunodeficiency 1/558 17/2131 0.994394977055745 0.999999955783023 IGLL1 1 KEGG hsa05131 Shigellosis 2/558 25/2131 0.995191629348344 0.999999955783023 MAPK10/PFN3 2 KEGG hsa04145 Phagosome 7/558 56/2131 0.99648822957626 0.999999955783023 ATP6V0E2/TUBA8/DYNC1I1/TUBB1/ATP6V1G2/NOX3/ATP6V1C2 7 KEGG hsa05145 Toxoplasmosis 6/558 52/2131 0.997455555860698 0.999999955783023 MAPK10/GNAO1/AKT3/CASP9/CYCS/PLA2G12A 6 KEGG hsa04062 Chemokine signaling pathway 10/558 74/2131 0.997659047433508 0.999999955783023 PLCB4/CCL15/ADCY1/GRK4/CCL27/ADCY2/GNG4/GNG2/AKT3/ADCY8 10 KEGG hsa04380 Osteoclast differentiation 5/558 47/2131 0.997841517343478 0.999999955783023 MAPK10/CALCR/NOX3/TNFRSF11B/AKT3 5 KEGG hsa05330 Allograft rejection 1/558 21/2131 0.998356562381747 0.999999955783023 IL4 1 KEGG hsa05150 Staphylococcus aureus infection 2/558 30/2131 0.998781044233125 0.999999955783023 PLG/DSG1 2 KEGG hsa05146 Amoebiasis 6/558 58/2131 0.999326114769158 0.999999955783023 PLCB4/ADCY1/GNAS/PRKCG/C8B/COL2A1 6 KEGG hsa04810 Regulation of actin cytoskeleton 13/558 97/2131 0.999418914614265 0.999999955783023 FGF17/FGF12/FGF22/APC2/CHRM4/F2/FGF13/SCIN/PAK4/FGF14/FGF9/FGF3/PFN3 13 KEGG hsa04110 Cell cycle 5/558 53/2131 0.999464987052193 0.999999955783023 CCNA1/CCND1/CCNE2/E2F2/SKP2 5 KEGG hsa05140 Leishmaniasis 1/558 27/2131 0.999740404906223 0.999999955783023 IL4 1 KEGG hsa05323 Rheumatoid arthritis 3/558 43/2131 0.999749667473072 0.999999955783023 ATP6V0E2/ATP6V1G2/ATP6V1C2 3 KEGG hsa04512 ECM-receptor interaction 5/558 57/2131 0.999795200664977 0.999999955783023 SV2A/TNR/IBSP/COL2A1/GP1BB 5 KEGG hsa04662 B cell receptor signaling pathway 1/558 33/2131 0.999959247037722 0.999999955783023 AKT3 1 KEGG hsa05100 Bacterial invasion of epithelial cells 1/558 33/2131 0.999959247037722 0.999999955783023 DNM3 1 KEGG hsa04660 T cell receptor signaling pathway 3/558 51/2131 0.999971080663579 0.999999955783023 IL4/PAK4/AKT3 3 KEGG hsa04670 Leukocyte transendothelial migration 3/558 51/2131 0.999971080663579 0.999999955783023 NOX3/PRKCG/RAPGEF4 3 KEGG hsa04510 Focal adhesion 11/558 103/2131 0.999981008475184 0.999999955783023 MAPK10/RASGRF1/CCND1/TNR/IBSP/PRKCG/COL2A1/PAK4/AKT3/IGF1R/KDR 11 KEGG hsa04640 Hematopoietic cell lineage 2/558 45/2131 0.99998282563721 0.999999955783023 IL4/GP1BB 2 KEGG hsa04650 Natural killer cell mediated cytotoxicity 3/558 55/2131 0.999990383316135 0.999999955783023 PRKCG/IFNA13/IFNA2 3 KEGG hsa04060 Cytokine-cytokine receptor interaction 13/558 118/2131 0.999991500803564 0.999999955783023 IL23R/CCL15/IL4/CCL27/TNFRSF11B/BMPR1B/PRLR/GH1/AMH/IL17RB/IFNA13/IFNA2/KDR 13 KEGG hsa05322 Systemic lupus erythematosus 3/558 74/2131 0.999999955783023 0.999999955783023 C8B/GRIN2A/H2AFV 3