compounds,"Binding 
 (IC50/µM)
(%inhibition at 10 µM)","Agonist 
(EC50/µM)
(%activation at 10 µM)","Inverse agonist 
(IC50/µM)
(%inhibition at 10 µM)","Antagonist 
(IC50/µM)
(%inhibition at 10 µM)","toxcity 
(IC50/µM)",SMILES format
T0901317,"0.036 ± 0.006 
(100 ± 1)%",NT,NT,NT,NT,O=S(N(CC(F)(F)F)C1=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C1)(C2=CC=CC=C2)=O
Rifampicin,NT,"1.4 ± 0.3
 (100 ± 4)%",NT,NT,NT,C[C@]12OC3=C(C)C(O)=C4C(C(O)=C(/C=N/N5CCN(C)CC5)C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O2)=O)=C4O)=C3C1=O
SPA70,"0.19 ± 0.03 
(95 ± 2)%",NA,"0.024 ± 0.007
(100 ± 3)%","0.25 ± 0.09
  (100 ± 1)%",NA,COC1=CC(N2N=NC(S(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)=C2C)=C(OC)C=C1
21,"2 ± 1 
(92 ± 8)%","2.5 ± 0.4 
(105 ± 5)%",NA,NA,NA,COC1=CC(N2N=NC(S(=O)(C3=CC=CC=C3)=O)=C2C)=C(OC)C=C1
22,"3.8 ± 0.7 
(104 ± 6)%","2.1 ± 0.4 
(90 ± 11)%",NA,NA,NA,COC1=CC(N2N=NC(S(=O)(C3=CC=C(C)C=C3)=O)=C2C)=C(OC)C=C1
23,"1.9 ± 0.4 
(102  ± 2)%","2.3 ± 0.3 
(99 ± 12)%",NA,NA,NA,COC1=CC(N2N=NC(S(=O)(C3=CC=C(Cl)C=C3)=O)=C2C)=C(OC)C=C1
24,"8.0 ± 0.1 
(95 ± 1)%","22 ± 6
 (138 ± 19)%",NA,NA,NA,COC1=C(N2N=NC(S(=O)(C3=CC=C(O)C=C3)=O)=C2C)C=C(OC)C=C1
25,"3.0 ± 0.6 
(104  ± 5)%","1.68 ± 0.08 
(83 ± 14)%",NA,NA,NA,COC1=CC(N2N=NC(S(=O)(C3=CC=C(OC)C=C3)=O)=C2C)=C(OC)C=C1
26,NA,NA,NA,NA,NA,COC1=CC(N2N=NC(S(C3=CC=C(C(O)=O)C=C3)(=O)=O)=C2C)=C(OC)C=C1
27,"5 ± 1 
(89  ± 7)%","7 ± 1 
(74 ± 10)%",NA,NA,NA,COC1=CC(N2N=NC(S(=O)(C3=CC=C(N)C=C3)=O)=C2C)=C(OC)C=C1
28,"1.0 ± 0.4 
(90 ± 6)%","3.4 ± 0.6
 (130 ± 10)%",NA,NA,NA,COC1=CC(N2N=NC(S(=O)(CC3=CC=CC=C3)=O)=C2C)=C(OC)C=C1
29,"8.7 ± 0.8 
(89 ± 1)%",NA,NA,NA,NA,COC1=CC(N2N=NC(S(C3=CC=C(C(OC)=O)C=C3)(=O)=O)=C2C)=C(OC)C=C1
30,"9.2 ± 0.7 
(80 ± 11)%",NA,NA,NA,NA,COC1=CC(N2N=NC(S(C3=CC=C(C(C)(O)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1
31,"3.7 ± 0.7 
(96 ± 4)%",NA,"0.4 ± 0.1
 (103 ± 3)%","2.3 ± 0.5
 (109 ± 5)%",NA,COC1=CC(N2N=NC(S(=O)(C3=CC=C(C(C)(OC)C)C=C3)=O)=C2C)=C(OC)C=C1
32,"2.1 ± 0.7 
(86 ± 3)%",NA,"0.25 ± 0.05
 (102 ± 4)%","1.35 ± 0.06
 (105 ± 2)%",NA,COC1=CC(N2N=NC(S(=O)(C3=CC=C(C(C)(OCCCC)C)C=C3)=O)=C2C)=C(OC)C=C1
41,"0.53 ± 0.09 
(103 ± 2)%","0.8 ± 0.3
 (56 ± 8)%",NA,"1.0 ± 0.2
 (53 ± 4)%",NA,[H]C1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1
42,"0.4 ± 0.1
 (80 ± 6)%","0.24 ± 0.09
 (37 ± 7)%",NA,"0.7 ± 0.1
 (70 ± 3)%",NA,FC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1
43,"0.25 ± 0.05
 (94 ± 2)%",NA,"0.27 ± 0.03 
(62 ± 2)%","0.31 ± 0.09
 (96 ± 5)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1
44,"0.40 ± 0.03
 (96 ± 3)%",NA,"0.05 ± 0.03 
(33 ± 4)%","0.24 ± 0.03
 (99 ± 2)%",NA,BrC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1
45,"0.8 ± 0.2
 (98 ± 1)%",NA,NA,"2 ± 2
 (85 ± 12)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1
46,"0.41 ± 0.04
 (90 ± 6)%",NA,NA,"1.01 ± 0.06
 (82 ± 4)%",NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=CC(C(F)(F)F)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
47,"0.3 ± 0.2
 (87 ± 1)%","0.38 ± 0.06
(113 ± 8)%",NA,NA,NA,CC(C)(C)C1=CC(N2N=NC(S(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)=C2C)=C(OC)C=C1
48,"0.4 ± 0.1
 (98 ± 4)%",NA,"0.05 ± 0.04 
(34 ± 3)%","0.45 ± 0.07
 (96 ± 1)%",NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=CC(C#N)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
50,"1.4 ± 0.7
 (95 ± 2)%","0.81 ± 0.02
(82 ± 5)%",NA,"2.0 ± 0.3
(64 ± 7)%",NA,O=S(C1=C(C)N(N=N1)C2=C(C=CC(CO)=C2)OC)(C3=CC=C(C(C)(C)C)C=C3)=O
51,"1.1 ± 0.1
 (95 ± 1)%","2.44 ± 0.02
 (182 ± 16)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(C=CC(C(N)=O)=C2)OC)(C3=CC=C(C(C)(C)C)C=C3)=O
54 (R),"1.1 ± 0.1
 (94 ± 2)%","0.44 ± 0.04
 (123 ± 22)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(C=CC([C@@H](C)O)=C2)OC)(C3=CC=C(C(C)(C)C)C=C3)=O
55 (S),"1.3 ± 0.4
 (95 ± 1)%","0.64 ± 0.01 
(112 ± 11)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(C=CC([C@H](C)O)=C2)OC)(C3=CC=C(C(C)(C)C)C=C3)=O
66,"4 ± 2
 (87 ± 7)%","1 ± 1
 (24 ± 1)%",NA,"2 ± 2
 (72 ± 13)%",NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(F)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
67,"0.7 ± 0.3
 (46 ± 14)%","0.6 ± 0.3 
(91 ± 12)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(Br)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
68,"0.7 ± 0.1 
(71 ± 4)%","0.8 ± 0.2
 (51 ± 13)%",NA,"2.0 ± 0.2
 (57 ± 2)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1Cl
69,"2.2 ± 0.3
 (77 ± 11)%","1.3 ± 0.3
 (87 ± 17)%",NA,NA,NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1Br
70,"0.55 ± 0.02
 (67 ± 7)%","0.6 ± 0.3
 (26 ± 4)%",NA,"3 ± 2
 (38 ± 7)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1Br
71,"0.9 ± 0.3 
(73 ± 7)%","0.6 ± 0.2 
(63 ± 13)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(Cl)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
72,"0.5 ± 0.1
 (73 ± 6)%","0.6 ± 0.1
 (75 ± 11)%",NA,"1.6 ± 0.4
 (30 ± 5)%",NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(C)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
73,"0.7 ± 0.2
 (65 ± 8)%","0.8 ± 0.1
 (125 ± 10)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(CC)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
74,"1.0 ± 0.5 
(68 ± 4)%","0.9 ± 0.2
 (110 ± 9)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(C(C)C)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
75,"1.3 ± 0.2
 (90 ± 1)%","1.05 ± 0.04
 (124 ± 11)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(OC)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
76,"0.36 ± 0.02
 (36 ± 8)%","1.1 ± 0.3 
(88 ± 15)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(C#N)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
77,"2.3 ± 0.2
 (72 ± 5)%","3.4 ± 0.1
 (78 ± 14)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(C(OC)=O)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O 
78,"0.9 ± 0.1
 (48 ± 4)%","0.5 ± 0.2
 (97 ± 10)%",NA,NA,NA,O=S(C1=C(C)N(N=N1)C2=C(OC)C=C(C(C)=O)C(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
79,"0.6 ± 0.2
 (94 ± 4)%",NA,NA,"0.7 ± 0.2 
(81 ± 2)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1F
80,"1.22 ± 0.04
 (84 ± 1)%","0.7 ± 0.2
 (52 ± 8)%",NA,"1.3 ± 0.1
 (60 ± 4)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C
81,"1.0 ± 0.4
 (76 ± 3)%","0.9 ± 0.3
 (138 ± 18)%",NA,NA,NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1CC
82,"2 ± 1
 (77 ± 5)%","0.83 ± 0.02
(122 ± 8)%",NA,NA,NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C(C)C
83,"0.84 ± 0.02 
(89 ± 4)%","0.28 ± 0.02
 (112 ± 13)%",NA,NA,NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1OC
84,"1.07 ± 0.03
 (48 ± 4)%","1.6 ± 0.3 
(58 ± 8)%",NA,"4 ± 2 
(33 ± 9)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C#N
85,"1.5 ± 0.1
 (64 ± 1)%","1.6 ± 0.3 
(75 ± 11)%",NA,"6 ± 1
 (32 ± 3)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C(OC)=O 
86,"1.4 ± 0.1
 (80 ± 4)%","0.4 ± 0.1
 (77 ± 12)%",NA,"9 ± 2
 (111  ± 10)%",16.5 ± 4.9,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C(C)=O
87,"0.4 ± 0.2
 (75 ± 11)%",NA,NA,"1.3 ± 0.7
 (102  ± 12)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1Cl
88,"1.2 ± 0.6
 (87 ± 7)%","1 ± 1
 (33 ± 1)%",NA,"2.3 ± 0.6
 (64 ± 2)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C
89,"1.5 ± 0.4
 (59 ± 4)%","0.7 ± 0.4 
(58 ± 8)%",NA,NA,NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1CC
90,"1.1 ± 0.3 
(73 ± 2)%","1.8 ± 0.6 
(99 ± 12)%",NA,NA,NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C(C)C
91,"0.47 ± 0.08
 (80 ± 1)%","0.25 ± 0.06
 (77 ± 7)%",NA,NA,NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1OC
92,"0.6 ± 0.2
 (40 ± 8)%","1.0 ± 0.4
 (49 ± 7)%",NA,"3.4 ± 0.4
 (44 ± 5)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C#N 
93,"0.7 ± 0.6
 (35 ± 9)%","1.9 ± 0.1
 (62 ± 1)%",NA,"10 ± 3 
(51 ± 2)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C(OC)=O
94,NA,"0.26 ± 0.09
 (65 ± 4)%",NA,NA,NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1C(C)=O
97,"0.8 ± 0.2
 (94 ± 1)%",NA,NA,"0.500 ± 0.007 
(82 ± 5)%",NA,O=S(C1=C(CC)N(N=N1)C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
98,"1.0 ± 0.3
 (90 ± 10)%",NA,NA,"0.8 ± 0.1 
(81 ± 5)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2CC)=C(OC)C=C1
99,"0.7 ± 0.1
 (93 ± 3)%",NA,NA,"0.96 ± 0.07 
(81 ± 4)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2CC)=C(OC)C=C1
100,"0.18 ± 0.05 
(85 ± 2)%","0.43 ± 0.05
 (53 ± 6)%",NA,"1.7 ± 0.1 
(52 ± 4)%",NA,O=S(C1=C(N)N(N=N1)C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
101,"0.28 ± 0.05
 (88 ± 6)%","0.16 ± 0.07
(73 ± 10)%",NA,"3.3 ± 0.4 
(46 ± 5)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2N)=C(OC)C=C1
102,"0.5 ± 0.1 
(93 ± 1)%","0.110 ± 0.008
 (42 ± 13)%",NA,"4.4 ± 0.5 
(78 ± 1)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2N)=C(OC)C=C1
103,"1.4 ± 0.3
 (98 ± 1)%","1.4 ± 0.2 
(35 ± 13)%",NA,"3.4 ± 0.3 
(71 ± 3)%",NA,O=S(C1=CN(N=N1)C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
104,"0.5 ± 0.2 
(98 ± 5)%","0.6 ± 0.2 
(69 ± 9)%",NA,"5 ± 1 
(44 ± 9)%",NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2)=C(OC)C=C1
105,"0.48 ± 0.05 
(91 ± 1)%","0.77 ± 0.09
 (65 ± 11)%",NA,"10.5 ± 0.1 
(57 ± 11)%",NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2)=C(OC)C=C1
109,"0.3 ± 0.1
 (97 ± 1)%","0.26 ± 0.06
 (88 ± 7)%",NA,"2.4 ± 0.2 
(38 ± 2)%",NA,O=S(C1=C(C#N)N(N=N1)C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
110,"0.21 ± 0.06
 (97 ± 1)%","0.16 ± 0.03
 (131 ± 23)%",NA,NA,NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C#N)=C(OC)C=C1
111,"0.061 ± 0.008 
(90 ± 2)%","0.08 ±0.04 
(105 ± 18)%",NA,NA,NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C#N)=C(OC)C=C1
112,"0.7 ± 0.3
 (91 ± 2)%","1.9 ± 0.7
 (135 ± 18)%",NA,NA,NA,O=S(C1=C(C(C)=O)N(N=N1)C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
113,"0.26 ± 0.09
 (94 ± 3)%","0.5 ± 0.2 
(125 ± 24)%",NA,NA,NA,CC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C(C)=O)=C(OC)C=C1
114,"0.4 ± 0.3
 (96 ± 4)%","0.20 ± 0.06
 (104 ± 11)%",NA,NA,NA,ClC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C(C)=O)=C(OC)C=C1
122,"2.5 ± 0.8
 (87 ± 13)%","4 ± 2 
(67 ± 3)%",NA,NA,NA,O=S(C(N1C)=CN=C1C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
123,"1.6 ± 0.6
 (92 ± 3)%","0.99 ± 0.05
 (74 ± 7)%",NA,NA,NA,CC1=CC(C2=NC=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2C)=C(OC)C=C1
124,"0.55 ± 0.02 
(60 ± 1)%","1.21 ± 0.05 
(81 ± 9)%",NA,NA,NA,ClC1=CC(C2=NC=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2C)=C(OC)C=C1
128,"3.08 ± 0.02 
(68 ± 16)%","0.7 ± 0.3 
(86 ± 4)%",NA,NA,NA,O=S(C(N1)=CN=C1C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
129,"1.4 ± 0.6
 (77 ± 13)%","0.7 ± 0.2 
(102 ± 12)%",NA,NA,NA,CC1=CC(C2=NC=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2)=C(OC)C=C1
130,"1.3 ± 0.5
 (81 ± 16)%","0.36 ± 0.07
 (71 ± 10)%",NA,NA,NA,ClC1=CC(C2=NC=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2)=C(OC)C=C1
140,"2.0 ± 0.4 
(84 ± 17)%","6 ± 2
 (86 ± 9)%",NA,NA,NA,O=S(C(N1)=C(C)N=C1C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
145,"0.9 ± 0.4
 (81 ± 16)%","0.5 ± 0.3
 (100 ± 10)%",NA,NA,NA,ClC1=CC(C2=NC(C)=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2)=C(OC)C=C1
150,"0.8 ± 0.3
 (82 ± 13)%","1.8 ± 0.4
 (106 ± 17)%",NA,NA,NA,CC1=CC(C2=NC(C)=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2)=C(OC)C=C1
155,"2.1 ± 0.4
 (80 ± 13)%","1.2 ± 0.3
 (97 ± 10)%",NA,NA,NA,O=S(C(N1C)=C(C)N=C1C2=C(OC)C=CC(OC)=C2)(C3=CC=C(C(C)(C)C)C=C3)=O
156,"0.4 ± 0.1 
(73 ± 2)%","1.0  ± 0.3
 (89 ± 9)%",NA,NA,NA,CC1=CC(C2=NC(C)=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2C)=C(OC)C=C1
157,"0.35 ± 0.03
(77 ± 4)%","1.2 ± 0.5 
(84 ± 9)%",NA,NA,NA,ClC1=CC(C2=NC(C)=C(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)N2C)=C(OC)C=C1
Binding: T0901317 (4) at 10 µM as 100% inhibition and DMSO (0.3%) as 0% inhibition for the hPXR binding assay,,,,,,
Agonist: Rifampicin  (1) at 10 µM as 100% activation and DMSO (0.3%) as 0% activation for the cell-based hPXR agonistic assay,,,,,,
Inverse agnist: SPA70 (10) at 10 µM as 100% inhibition and DMSO (0.3%) as 0% inhibition for the cell-based hPXR inverse agonistic assay,,,,,,
"Antagonist: SPA70 (10) at 10 µM with rifampicin  (1, 5 µM) as 100% inhibition and rifampicin alone (1, 5 µM) as 0% inhibition for the cell-based hPXR antagonistic assay",,,,,,
NT: not tested,,,,,,
NA: no IC50 value could be experimentally determined within the concentration range tested (highest concentration tested at 30 µM),,,,,,