Supplementary Table 1: Differentially expressed genes of wild type "empty" and SE-deleted unstimulated versus stimulated EL-4 cell clones.
“Empty” and SE EL-4 cell clones (3+3) were left unstimulated or stimulated with PMA and ionomycin for 6 h and genome-wide transcription profile was assessed with RNA sequencing. Differential expression was analysed using DEseq2 takig into account the genotype and the stimulation status of the cells. Shown are the gene symbol, fold change values (log2FoldChange) and adjusted p values of 141 differentially expressed genes (p adj<0.05).
,symbol,log2FoldChange,padj
1,Plcb4,7.05666718381111,0.000906938233995
2,Renbp,4.64392533033369,6.25189461708925E-06
3,Dab2ip,3.02229171730929,0.001934381722103
4,Rassf2,-2.24114566736017,0.025317474299933
5,Rerg,2.21429285995709,0.017902033701762
6,Gimap4,-2.08202426194236,0.000883137654491
7,Ifnlr1,-1.70380892163881,0.022238705208558
8,Adamtsl2,-1.53057420406291,5.48528554340668E-05
9,Olfr524,-1.31030725714232,0.001329798311636
10,Cd163l1,-1.22921991237028,0.000235038436916
11,Gpm6b,-1.20216035369781,2.53759781883706E-06
12,Kcnt2,-1.15404143245004,0.009685962571951
13,BC147527,-1.10082045830199,0.033244764616919
14,Zfp532,1.09559958185219,0.000183083225503
15,A430088P11Rik,-1.05912261141906,0.007144587257984
16,Flnc,-1.01482377591238,0.039107572451041
17,Batf2,-1.00404602166536,0.032380607284039
18,Ly6c2,-0.998380188517194,0.009684870313168
19,Slc28a2b,-0.990847776679849,0.000747060398379
20,Adam33,-0.965451565504198,0.004329734765174
21,Dysf,-0.958160642022341,0.006768385710905
22,Irf8,-0.924480798095359,5.55573047631611E-09
23,Ly75,-0.836526468882657,5.25950262608539E-07
24,Vat1,0.829842006097441,0.022892190713212
25,Slc30a2,-0.784384295299886,0.019418707696199
26,Dhx58,-0.780833690966392,0.014445731245442
27,Igfbp7,-0.712168718048817,0.035625440316824
28,Sema4f,-0.700415809399311,0.01274728603378
29,Mogat2,0.69882401556426,0.005086505800886
30,Tns1,-0.648672412992884,0.018006316462554
31,Cd3d,-0.598821056096242,0.040460303290705
32,Eps8,0.587637219300195,0.028029515396499
33,LOC115487916,0.585849277153141,0.025317474299933
34,Tspan2,-0.577179116158423,0.046818046329671
35,Ppm1l,0.561598848918857,0.011517444953448
36,Mfge8,0.559736005896964,0.002201587393411
37,Dusp18,0.549498896641371,0.021674175684991
38,Fam102a,-0.541444341625059,0.033244764616919
39,Sphk1,0.536713586160372,0.04007458785224
40,Camk1g,-0.532724241372576,0.001530972782174
41,Limd2,-0.529499757837821,8.2553598038758E-05
42,Tmem119,0.509369033293883,0.046325636447413
43,Lef1,-0.488511847097981,0.006459035263356
44,Plcg1,-0.486204484875037,0.002201587393411
45,Lipg,-0.468260978743902,0.003016492984633
46,Ikzf2,-0.442063990981278,6.91396230323049E-06
47,Xlr4a,0.437839396298626,0.00022364889826
48,Arc,-0.434215871772462,0.031562321328737
49,Fads6,0.429577965240207,0.022892190713212
50,Pcyt1a,0.421710387265736,0.000262207129376
51,Malat1,0.421381613147242,0.004031807759864
52,Xlr4b,0.419353419908364,0.000129021392248
53,Pcdh19,-0.418706082451543,0.0426256092464
54,Tecpr1,0.416659982517839,0.004120780288949
55,Dusp3,0.410228011841755,0.001973287889615
56,Herc6,-0.404910292189337,0.046325636447413
57,Lgals9,-0.403607352107915,0.046325636447413
58,Slc16a6,0.39111246955884,2.7085669145203E-05
59,Lax1,-0.389846530436283,0.001934381722103
60,Usp53,0.384958144129207,0.019418707696199
61,Myzap,0.383983115514056,0.000651407042248
62,Hoxb9,-0.380719391724229,0.008879457086037
63,Cd320,0.376660728655497,0.022892190713212
64,Scml4,-0.361713351553682,0.009289497606608
65,Daam1,0.354296391913484,0.009684870313168
66,H2bc7,-0.348819703126576,0.006786310387875
67,Slamf9,-0.344661427980103,0.014445731245442
68,Gimap9,-0.342322129960107,0.019418707696199
69,Prkd2,-0.338264132869794,0.022892190713212
70,Vcl,0.338245480916364,0.010309208891358
71,Il16,-0.336183336862347,0.045026884958315
72,Lbhd1,0.323136084784931,0.028626774167262
73,Tespa1,-0.321272546185653,0.041205750564096
74,Cir1,0.32121727203532,0.008879457086037
75,Slc28a2,-0.317217065983079,0.019418707696199
76,Psme1,-0.313696308394692,0.040981091205742
77,Ier3,0.312238383965852,0.046325636447413
78,Cmtm4,0.311818491870645,0.019418707696199
79,Tulp3,-0.310380647902011,0.000140864623312
80,Snrpa1,-0.307455180905466,0.04007458785224
81,H2ac11,-0.30599274012122,0.04007458785224
82,H4c11,-0.302274220720189,0.012084737179618
83,Cnp,-0.298390151816984,0.035625440316824
84,Gm14322,0.296691816172679,0.035114988448184
85,Itgal,-0.29285606823351,0.012340584856584
86,Usp11,-0.289035309172737,0.032289838688162
87,Strada,-0.28611943835067,0.047408985715013
88,Ubald2,-0.285357992361707,0.006082652273886
89,Spc24,-0.279372668179647,0.039107572451041
90,Gm16001,0.27587323027298,0.006099750967237
91,Aff3,-0.2749021998836,0.048440199973971
92,Ccdc146,0.268708793004192,0.000194928667939
93,Firre,0.264745697717351,0.006617240458044
94,H2ac15,-0.259149487882765,0.032306094348614
95,H2bc15,-0.256833406189387,0.033244764616919
96,Cfap74,-0.253678141406279,0.040460303290705
97,H4c6,-0.253154974647189,0.031471296546885
98,Ncf4,-0.252963216112724,0.027809132811869
99,H3c8,-0.246060369315361,0.027809132811869
100,Zfp568,0.246041494479039,0.040460303290705
101,Fam199x,0.244119993231014,0.022892190713212
102,Snx13,0.235799338249817,0.026510117938907
103,Mgat4a,-0.233917873248184,0.044687276178726
104,H3c1,-0.231227723893255,0.001941995387118
105,Arhgap27,-0.230348885736924,8.22493633805246E-05
106,Sgsm2,0.227171630364117,0.024373061553054
107,Hmgcr,0.227019797199984,0.010309208891358
108,Amer1,-0.226474211413281,0.04007458785224
109,H3c7,-0.226318057919786,0.032380607284039
110,Mxi1,0.213990743219071,0.028626774167262
111,Ccdc15,-0.202363431594395,0.04007458785224
112,Fanca,-0.197615147446291,0.022892190713212
113,H3c6,-0.195739050944513,0.031023031324991
114,Asf1b,-0.186331181260201,0.031312113942747
115,Nup210,-0.185892223887339,0.036735838460266
116,Fam136a,0.181962661492127,0.017902033701762
117,Trmt1l,-0.180297804967827,0.00874586264126
118,Arid1a,-0.163223622673467,0.022892190713212
119,Arfip2,0.159029004576997,0.04007458785224
120,Sdr9c7,0.150666073291633,0.02393766231492
121,Mrps9,-0.147352571623186,0.038479313601076
122,Vti1b,0.147079728785643,0.042211902733546
123,Apol9b,-0.013411317475964,0.032306094348614
124,Mpeg1,-0.012243601855726,0.031562321328737
125,Gimap1,-0.011385156684188,0.031562321328737
126,Phf11a,-0.011126473953765,0.002743360160009
127,Atp8a2,-0.00904839603648,0.009737021935369
128,Tfr2,-0.007417490244193,0.024239804134345
129,Mst1,-0.007006139135099,0.025190403394927
130,Evl,-0.005216459623008,0.026325263562928
131,Trim29,-0.004291420736414,0.035625440316824
132,Iigp1,-0.004031218924478,0.040460303290705
133,Gm4841,-0.003683451439013,0.002743360160009
134,F830016B08Rik,-0.002791443713129,0.009704004238308
135,Fbn1,-0.002684125008609,0.022792016863383
136,Gvin1,-0.002571939638948,0.000651407042248
137,Gm4951,-0.002338358710128,0.008879457086037
138,Ifi44,-0.002193949801628,0.009684870313168
139,Pi15,-0.001628953902267,0.0426256092464
140,Gm4070,-0.001158695652519,0.032994055232339