Method Trait Cell_Type beta se P fdr meanlog10P LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Medium Spiny Neuron 3.64932281548e-8 5.5849798739e-9 3.1980862402747334e-11 6.907866278993424e-9 10.418926568815195 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Medium Spiny Neuron 0.227 0.035 4.5421e-11 4.7281536e-9 10.418926568815195 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) pyramidal CA1 3.06110481531e-8 5.14350783624e-9 1.329330756583147e-9 1.9142362894797316e-7 9.950166758722702 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) pyramidal CA1 0.233 0.0347 9.4631e-12 1.3626864e-9 9.950166758722702 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Medium Spiny Neuron 5.72683399888e-9 1.1384620132e-9 2.448244834640789e-7 2.6441044214120524e-5 9.872538246749972 MAGMA Top 10% Educational attainment (Lee et al., 2018) Medium Spiny Neuron 0.302 0.0408 7.3463e-14 3.1736016e-11 9.872538246749972 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Medium Spiny Neuron 4.27249491805e-8 6.41423357168e-9 1.3602341475404955e-11 5.876211517374941e-9 9.111333616556873 MAGMA Top 10% Bipolar (Stahl et al., 2018) Medium Spiny Neuron 0.15 0.0281 4.4027e-8 2.3774580000000002e-6 9.111333616556873 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) pyramidal SS 5.7798488983e-9 1.21347525617e-9 9.534211049544439e-7 6.864631955671996e-5 8.732405511915985 MAGMA Top 10% Educational attainment (Lee et al., 2018) pyramidal SS 0.273 0.0397 3.5967e-12 7.768871999999999e-10 8.732405511915985 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) pyramidal CA1 1.00267250882e-8 2.22749234398e-9 3.3761431913470474e-6 1.8231173233274056e-4 7.786569598477502 MAGMA Top 10% Intelligence (Savage et al., 2018) pyramidal CA1 0.214 0.0334 7.9148e-11 5.698656e-9 7.786569598477502 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) pyramidal SS 1.09171175764e-8 2.56384588945e-9 1.0308489236221519e-5 4.453267350047696e-4 7.624313571994265 MAGMA Top 10% Intelligence (Savage et al., 2018) pyramidal SS 0.215 0.0332 5.4724e-11 4.7281536e-9 7.624313571994265 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) pyramidal CA1 4.8036057822e-9 1.16842143168e-9 1.9681016462658185e-5 7.085165926556947e-4 7.363363719038826 MAGMA Top 10% Educational attainment (Lee et al., 2018) pyramidal CA1 0.257 0.0403 9.5329e-11 5.883161142857143e-9 7.363363719038826 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) pyramidal SS 2.7129863003e-8 5.57192316018e-9 5.607359069292883e-7 4.844758235869051e-5 6.556880461710307 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) pyramidal SS 0.177 0.0343 1.3724e-7 4.56059076923077e-6 6.556880461710307 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) pyramidal CA1 3.07702121645e-8 6.51050958518e-9 1.1435926852154665e-6 7.05760057161545e-5 6.274375222324508 MAGMA Top 10% Bipolar (Stahl et al., 2018) pyramidal CA1 0.14 0.0278 2.4716e-7 7.118208e-6 6.274375222324508 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Medium Spiny Neuron 1.0046074504300001e-08 2.26464986551e-9 4.581468555309165e-6 2.1991049065483992e-4 6.122751781418632 MAGMA Top 10% Intelligence (Savage et al., 2018) Medium Spiny Neuron 0.177 0.0343 1.2402e-7 4.4647199999999995e-6 6.122751781418632 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) pyramidal SS 5.04087339695e-9 1.30682477517e-9 5.731277072373864e-5 0.001768508353761078 5.172691118327201 MAGMA Top 10% Neuroticism (Nagel et al., 2018) pyramidal SS 0.141 0.0294 7.8771e-7 2.126817e-5 5.172691118327201 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Neuroblasts 7.42125540009e-9 2.67157370119e-9 0.0027359167443479215 0.04457214480281202 4.847661789242858 MAGMA Top 10% BMI (Yengo et al., 2018) Neuroblasts 0.227 0.0432 7.3718e-8 2.895106909090909e-6 4.847661789242858 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Medium Spiny Neuron 4.75252407405e-9 2.06945928153e-9 0.010823505086008822 0.10873846970129794 4.59039688430728 MAGMA Top 10% BMI (Yengo et al., 2018) Medium Spiny Neuron 0.236 0.0446 6.0931e-8 2.8395792e-6 4.59039688430728 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) pyramidal CA1 7.51175648327e-9 3.4081159675e-9 0.013759397981524923 0.12383458183372431 4.521815164001844 MAGMA Top 10% BMI (Yengo et al., 2018) pyramidal CA1 0.24 0.0454 6.5731e-8 2.8395792e-6 4.521815164001844 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Embryonic GABAergic Neuron 6.21657650753e-9 2.58973190454e-9 0.008186992567231655 0.09068668689856602 4.376905701471759 MAGMA Top 10% BMI (Yengo et al., 2018) Embryonic GABAergic Neuron 0.22 0.0436 2.1531e-7 6.643851428571428e-6 4.376905701471759 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Neuroblasts 9.21199676127e-9 2.97714567074e-9 9.865962020358943e-4 0.021310477963975318 4.31811829203697 MAGMA Top 10% Intelligence (Savage et al., 2018) Neuroblasts 0.147 0.0321 2.3422e-6 5.951943529411765e-5 4.31811829203697 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) pyramidal SS 2.56281288931e-8 6.27257782368e-9 2.196817659194661e-5 7.300194067477643e-4 3.7233024724284247 MAGMA Top 10% Bipolar (Stahl et al., 2018) pyramidal SS 0.0814 0.0277 0.0016278 0.02009170285714286 3.7233024724284247 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) pyramidal SS 6.97689146198e-9 2.51692748813e-9 0.002785759050175751 0.04457214480281202 3.650568594663624 MAGMA Top 10% BMI (Yengo et al., 2018) pyramidal SS 0.188 0.0455 1.7944e-5 4.3065599999999996e-4 3.650568594663624 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Hypothalamic Glutamatergic Neurons 7.32589169936e-9 2.75492301581e-9 0.00391632080880655 0.05779980081298088 3.445670295390711 MAGMA Top 10% BMI (Yengo et al., 2018) Hypothalamic Glutamatergic Neurons 0.177 0.0442 3.2793e-5 7.456092631578948e-4 3.445670295390711 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) pyramidal CA1 4.88756828483e-9 1.16663907507e-9 1.3981980590882515e-5 5.491105104782952e-4 3.3579695689617344 MAGMA Top 10% Neuroticism (Nagel et al., 2018) pyramidal CA1 0.0661 0.03 0.013756000000000001 0.092853 3.3579695689617344 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Neuroblasts 2.59453858815e-8 6.80518903872e-9 6.875946514883768e-5 0.0019802725962865253 3.3405694456356234 MAGMA Top 10% Autism (Grove et al., 2017) Neuroblasts 0.0696 0.0254 0.0030306 0.031171885714285717 3.3405694456356234 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Striatal Interneuron 3.74440895845e-9 1.12795986847e-9 4.506847891819765e-4 0.010816434940367436 3.2536925109275745 MAGMA Top 10% Educational attainment (Lee et al., 2018) Striatal Interneuron 0.129 0.0404 6.8983e-4 0.011920262400000001 3.2536925109275745 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Hypothalamic GABAergic Neurons 1.04486346926e-8 4.64409312259e-9 0.012228401850237325 0.11739265776227831 3.0942468763285396 MAGMA Top 10% BMI (Yengo et al., 2018) Hypothalamic GABAergic Neurons 0.172 0.0444 5.2983e-5 0.0011444328 3.0942468763285396 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) pyramidal SS 7.79072762371e-9 2.99495049314e-9 0.004643727644303874 0.06457043516238498 3.007149033965144 MAGMA Top 10% Age at menarche (Perry et al., 2014) pyramidal SS 0.104 0.0295 2.0837e-4 0.004286468571428572 3.007149033965144 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) interneurons 1.8001898281e-8 5.70805770895e-9 8.058816799070279e-4 0.018323204511570317 2.9276531105191923 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) interneurons 0.102 0.0349 0.0017315 0.020777999999999998 2.9276531105191923 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Neuroblasts 2.78265591481e-9 9.27525632099e-10 0.0013495205182549874 0.027761564946959742 2.892050956415945 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Neuroblasts 0.0837 0.0276 0.0012182 0.017731636363636366 2.892050956415945 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Medium Spiny Neuron 4.86328187843e-9 1.36627852009e-9 1.8577378455264526e-4 0.005015892182921422 2.8893028929660893 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Medium Spiny Neuron 0.0706 0.0298 0.0089621 0.06555960000000001 2.8893028929660893 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Embryonic GABAergic Neuron 8.58829211767e-9 2.5104399571e-9 3.119214696408745e-4 0.007926474993226929 2.844508895888585 MAGMA Top 10% Intelligence (Savage et al., 2018) Embryonic GABAergic Neuron 0.0806 0.0325 0.0065605 0.05450261538461539 2.844508895888585 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) interneurons 6.10677619406e-9 2.38170428752e-9 0.005173136507403475 0.06772105973328187 2.772929841874917 MAGMA Top 10% Intelligence (Savage et al., 2018) interneurons 0.11 0.0336 5.5003e-4 0.00990054 2.772929841874917 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) pyramidal SS 1.50082473142e-8 5.41300802705e-9 0.0027802985682934267 0.04457214480281202 2.7310508941614686 MAGMA Top 10% ADHD (Demontis et al., 2017) pyramidal SS 0.0814 0.0269 0.0012411 0.017731636363636366 2.7310508941614686 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) pyramidal CA1 8.21287410814e-9 2.91312835809e-9 0.0024067053664088567 0.04332069659535942 2.4774804714410923 MAGMA Top 10% Age at menarche (Perry et al., 2014) pyramidal CA1 0.0771 0.0296 0.0046091 0.041481899999999995 2.4774804714410923 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) interneurons 2.23368010347e-9 1.16510124213e-9 0.027609097991898368 0.21298447022321598 2.4643362480344138 MAGMA Top 10% Educational attainment (Lee et al., 2018) interneurons 0.135 0.0404 4.2685e-4 0.00801735652173913 2.4643362480344138 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Embryonic GABAergic Neuron 1.21336444845e-8 5.6351235541e-9 0.015650809582115288 0.13257156351909422 2.4115439610684195 MAGMA Top 10% Autism (Grove et al., 2017) Embryonic GABAergic Neuron 0.0781 0.0252 9.6023e-4 0.01536368 2.4115439610684195 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Neuroblasts 4.32070477207e-9 1.90190215526e-9 0.011549876980770146 0.11339879217483416 2.406654924638488 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Neuroblasts 0.0865 0.0288 0.0013308 0.017731636363636366 2.406654924638488 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Striatal Interneuron 1.55743544621e-8 5.70852327734e-9 0.00318343842259039 0.04911590709139459 2.305145724670344 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Striatal Interneuron 0.084 0.0347 0.0077057 0.0616456 2.305145724670344 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Embryonic GABAergic Neuron 2.33029488629e-9 1.24171532475e-9 0.030281392958220743 0.22404025495175994 2.2790982139409763 MAGMA Top 10% Educational attainment (Lee et al., 2018) Embryonic GABAergic Neuron 0.123 0.0395 9.1333e-4 0.015175329230769231 2.2790982139409763 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Neuroblasts 1.74726286531e-9 1.41569774002e-9 0.1085630471132123 0.4225156428189884 2.228710383493375 MAGMA Top 10% Educational attainment (Lee et al., 2018) Neuroblasts 0.131 0.0385 3.2129e-4 0.006308967272727273 2.228710383493375 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) interneurons 2.21552925176e-9 9.10486073329e-10 0.0074799623852684904 0.08975954862322189 2.216833948783382 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) interneurons 0.0726 0.0281 0.0049253 0.04342305306122448 2.216833948783382 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Striatal Interneuron 1.97133821767e-8 6.80248972862e-9 0.001877958081684672 0.0352729517951208 2.115266976819588 MAGMA Top 10% Bipolar (Stahl et al., 2018) Striatal Interneuron 0.0524 0.0281 0.031317 0.15032159999999997 2.115266976819588 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Striatal Interneuron 6.40862652952e-9 3.47714488388e-9 0.032659288167926515 0.2312920080089222 2.0601310069235534 MAGMA Top 10% BMI (Yengo et al., 2018) Striatal Interneuron 0.127 0.045 0.0023213 0.026389515789473687 2.0601310069235534 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Serotonergic Neuron 2.32321443722e-9 1.24098340721e-9 0.030598090375356102 0.22404025495175994 2.0511074496132946 MAGMA Top 10% Educational attainment (Lee et al., 2018) Serotonergic Neuron 0.111 0.0398 0.0025828 0.027894240000000004 2.0511074496132946 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Dopaminergic Neuroblast 4.61039775361e-9 2.34785763697e-9 0.024784677515815146 0.19827742012652116 2.0390354292198385 MAGMA Top 10% Intelligence (Savage et al., 2018) Dopaminergic Neuroblast 0.0882 0.0326 0.0033709 0.03309610909090909 2.0390354292198385 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Neural Progenitors 1.99581894899e-8 1.30021150434e-8 0.062392453403564696 0.33464488195280323 2.0365444636423877 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Neural Progenitors 0.0765 0.0255 0.0013545 0.017731636363636366 2.0365444636423877 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Serotonergic Neuron 3.15752100529e-9 2.55716541291e-9 0.10845733940276525 0.4225156428189884 1.972334975017541 MAGMA Top 10% BMI (Yengo et al., 2018) Serotonergic Neuron 0.137 0.0445 0.0010473 0.016158342857142856 1.972334975017541 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Hypothalamic Glutamatergic Neurons 8.63085037735e-9 3.58374584999e-9 0.008012796592616445 0.09068668689856602 1.94281492845854 MAGMA Top 10% Age at menarche (Perry et al., 2014) Hypothalamic Glutamatergic Neurons 0.0624 0.0292 0.01624 0.10167652173913044 1.94281492845854 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) interneurons 1.91131559609e-8 6.54902829103e-9 0.0017587570910755357 0.03453559378839234 1.922295714020473 MAGMA Top 10% Bipolar (Stahl et al., 2018) interneurons 0.0386 0.0277 0.081321 0.3028506206896552 1.922295714020473 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Embryonic Dopaminergic Neuron 3.88811113538e-9 3.00753711959e-9 0.09804200972021893 0.40699751134811535 1.910293961255749 MAGMA Top 10% BMI (Yengo et al., 2018) Embryonic Dopaminergic Neuron 0.128 0.0433 0.0015417 0.01958865882352941 1.910293961255749 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) interneurons 9.43788396399e-9 5.69835908466e-9 0.04883601405250515 0.3013879724383175 1.9008942189335623 MAGMA Top 10% ADHD (Demontis et al., 2017) interneurons 0.073 0.0268 0.003232 0.03247032558139535 1.9008942189335623 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Medium Spiny Neuron 6.37038878986e-9 2.7358985125e-9 0.009944247352488667 0.1056487206921664 1.8866548131468033 MAGMA Top 10% Age at menarche (Perry et al., 2014) Medium Spiny Neuron 0.0619 0.0292 0.016948 0.10458659154929577 1.8866548131468033 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Dopaminergic Neuroblast 7.13103060064e-9 3.20251371669e-9 0.012983735097290894 0.1193398630219078 1.8385560742197353 MAGMA Top 10% BMI (Yengo et al., 2018) Dopaminergic Neuroblast 0.094 0.044 0.016199 0.10167652173913044 1.8385560742197353 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Striatal Interneuron 4.91905960631e-9 2.27414980567e-9 0.015269345644817411 0.13192714637122244 1.829270754887412 MAGMA Top 10% Intelligence (Savage et al., 2018) Striatal Interneuron 0.0735 0.0336 0.014376 0.09409745454545455 1.829270754887412 LDSC Top 10% (Z P) Autism (Grove et al., 2017) pyramidal CA1 8.33233925705e-9 5.47255668708e-9 0.06393342028833904 0.33464488195280323 1.8009477094263926 MAGMA Top 10% Autism (Grove et al., 2017) pyramidal CA1 0.0692 0.026 0.0039118 0.035955268085106386 1.8009477094263926 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Dopaminergic Neuroblast 1.73185091001e-9 1.37628187838e-9 0.10413173511917928 0.4127055923989491 1.7950534675616603 MAGMA Top 10% Educational attainment (Lee et al., 2018) Dopaminergic Neuroblast 0.11 0.0392 0.0024678 0.02733563076923077 1.7950534675616603 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Medium Spiny Neuron 7.94241620283e-9 5.35746400927e-9 0.06910425208256055 0.33464488195280323 1.7908535390890705 MAGMA Top 10% Autism (Grove et al., 2017) Medium Spiny Neuron 0.0699 0.0262 0.0037913 0.03560525217391305 1.7908535390890705 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Hypothalamic Dopaminergic Neurons 1.57489897074e-9 1.33899138486e-9 0.11976086817489606 0.4420747909327217 1.7779862512287739 MAGMA Top 10% Educational attainment (Lee et al., 2018) Hypothalamic Dopaminergic Neurons 0.112 0.0395 0.0023212 0.026389515789473687 1.7779862512287739 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Dopaminergic Adult 9.78596341682e-9 3.7767089295e-9 0.004782995197213702 0.06457043516238498 1.7497669601235781 MAGMA Top 10% Age at menarche (Perry et al., 2014) Dopaminergic Adult 0.045 0.0299 0.066186 0.26973916981132073 1.7497669601235781 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) interneurons 9.48559763061e-10 2.52120600182e-9 0.35337200936403357 0.7304148710299642 1.6720415671625108 MAGMA Top 10% BMI (Yengo et al., 2018) interneurons 0.137 0.0453 0.0012814 0.017731636363636366 1.6720415671625108 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Dopaminergic Neuroblast 1.37950332617e-9 8.70821244516e-10 0.056580858625643216 0.33464488195280323 1.6705300442808793 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Dopaminergic Neuroblast 0.0654 0.0272 0.0080588 0.06271522758620689 1.6705300442808793 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Medium Spiny Neuron 7.85719314093e-9 5.32372912349e-9 0.06998785797447449 0.33464488195280323 1.6618321702350798 MAGMA Top 10% ADHD (Demontis et al., 2017) Medium Spiny Neuron 0.0679 0.0275 0.0067813 0.055273992452830184 1.6618321702350798 LDSC Top 10% (Z P) Parkinson's disease (this study) Dopaminergic Neuroblast 2.03092298154e-9 1.45490843712e-9 0.08137061884369956 0.3470096842912694 1.6600627560805923 MAGMA Top 10% Parkinson's disease (this study) Dopaminergic Neuroblast 0.0662 0.0263 0.0058804 0.050087435294117647 1.6600627560805923 LDSC Top 10% (Z P) Anorexia (PGC, 2018) pyramidal CA1 7.49198909235e-9 4.14791586488e-9 0.03544311095699171 0.23934398498631315 1.6518755649652115 MAGMA Top 10% Anorexia (PGC, 2018) pyramidal CA1 0.0589 0.0268 0.014019 0.09317243076923078 1.6518755649652115 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Embryonic midbrain nucleus neurons 1.90829712089e-9 1.23476845971e-9 0.06111635797924708 0.33464488195280323 1.6442626422989344 MAGMA Top 10% Educational attainment (Lee et al., 2018) Embryonic midbrain nucleus neurons 0.0943 0.0394 0.0084201 0.06271522758620689 1.6442626422989344 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Embryonic GABAergic Neuron 3.35454706948e-9 1.61612269894e-9 0.01896196440047271 0.1575301657885425 1.635941482789211 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Embryonic GABAergic Neuron 0.0552 0.0289 0.028199 0.13979127272727274 1.635941482789211 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Embryonic midbrain nucleus neurons 1.62636168936e-8 6.13512927187e-9 0.004013875056457006 0.05779980081298088 1.6357541356036536 MAGMA Top 10% Autism (Grove et al., 2017) Embryonic midbrain nucleus neurons 0.0281 0.0253 0.13333 0.41252914285714287 1.6357541356036536 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Embryonic Dopaminergic Neuron 8.80959473769e-9 5.9273857872e-9 0.06860611052044951 0.33464488195280323 1.6222612416567024 MAGMA Top 10% Autism (Grove et al., 2017) Embryonic Dopaminergic Neuron 0.061 0.0255 0.0083007 0.06271522758620689 1.6222612416567024 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Dopaminergic Adult 1.54605769699e-9 1.54503250871e-9 0.15849475035122718 0.5034539128803687 1.6137542542023895 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Dopaminergic Adult 0.0792 0.0296 0.0037366 0.03560525217391305 1.6137542542023895 LDSC Top 10% (Z P) Parkinson's disease (this study) Neuroblasts 2.04465827326e-9 9.4403361719e-10 0.015160391841340659 0.13192714637122244 1.6043359952519198 MAGMA Top 10% Parkinson's disease (this study) Neuroblasts 0.0453 0.026 0.040796 0.183582 1.6043359952519198 LDSC Top 10% (Z P) Parkinson's disease (this study) Dopaminergic Adult 2.24922493356e-9 9.75183486032e-10 0.010542378911925665 0.10843589737980684 1.5857021148305015 MAGMA Top 10% Parkinson's disease (this study) Dopaminergic Adult 0.0414 0.0272 0.063923 0.26299748571428566 1.5857021148305015 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Medium Spiny Neuron 1.60992253836e-9 8.67681262635e-10 0.03176736633546706 0.22872503761536286 1.5767739584166678 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Medium Spiny Neuron 0.0581 0.0289 0.022104 0.11645034146341464 1.5767739584166678 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Dopaminergic Adult 1.23733789089e-9 9.71482734841e-10 0.10139211677483217 0.408577191097371 1.536664977326008 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Dopaminergic Adult 0.0674 0.0281 0.0083304 0.06271522758620689 1.536664977326008 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Embryonic Dopaminergic Neuron 4.83087041189e-9 2.56108627802e-9 0.02963007354271807 0.22404025495175994 1.5101787263082964 MAGMA Top 10% Intelligence (Savage et al., 2018) Embryonic Dopaminergic Neuron 0.0605 0.0327 0.032204000000000003 0.15121878260869567 1.5101787263082964 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Hypothalamic Dopaminergic Neurons 8.8168295674e-10 2.86513306288e-9 0.3791444847499449 0.7471847255314712 1.4886221019724857 MAGMA Top 10% BMI (Yengo et al., 2018) Hypothalamic Dopaminergic Neurons 0.122 0.044 0.0027794 0.02928538536585366 1.4886221019724857 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) pyramidal CA1 1.42497702688e-9 9.19419040005e-10 0.06058674726745017 0.33464488195280323 1.4750845106613593 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) pyramidal CA1 0.0595 0.0285 0.018512 0.10766015999999999 1.4750845106613593 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Embryonic GABAergic Neuron 4.4151336637e-9 5.10644834711e-9 0.19362389501302268 0.5260724694693446 1.4706129120060096 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Embryonic GABAergic Neuron 0.0838 0.0333 0.0059131 0.050087435294117647 1.4706129120060096 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Striatal Interneuron 6.88235954081e-9 5.42162428994e-9 0.10214429777434275 0.408577191097371 1.4602077412816548 MAGMA Top 10% Autism (Grove et al., 2017) Striatal Interneuron 0.0579 0.0256 0.011759 0.08193367741935484 1.4602077412816548 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Serotonergic Neuron 6.33929731322e-9 2.8362093828e-9 0.012704400331157384 0.11931089006652153 1.4375316933169255 MAGMA Top 10% Intelligence (Savage et al., 2018) Serotonergic Neuron 0.0416 0.0332 0.10495 0.35420625 1.4375316933169255 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) endothelial-mural 8.99476464312e-10 5.91564144925e-10 0.06419200395475166 0.33464488195280323 1.4304952736854584 MAGMA Top 10% Stroke (Malik et al., 2018) endothelial-mural 0.0504 0.0249 0.021455 0.11442666666666665 1.4304952736854584 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Medium Spiny Neuron 5.83161610228e-9 3.90072626179e-9 0.06745620608283165 0.33464488195280323 1.425675802092869 MAGMA Top 10% Anorexia (PGC, 2018) Medium Spiny Neuron 0.0553 0.0272 0.020875 0.11272500000000002 1.425675802092869 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) pyramidal CA1 7.63462111211e-9 5.07325264915e-9 0.06617785417549227 0.33464488195280323 1.4091860923862725 MAGMA Top 10% ADHD (Demontis et al., 2017) pyramidal CA1 0.0535 0.0268 0.022957 0.11806457142857145 1.4091860923862725 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Striatal Interneuron 4.65484308003e-9 3.06306000126e-9 0.06429685722083378 0.33464488195280323 1.3924477750960609 MAGMA Top 10% Age at menarche (Perry et al., 2014) Striatal Interneuron 0.0581 0.0298 0.025522 0.12820353488372094 1.3924477750960609 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Hypothalamic Dopaminergic Neurons 2.11343203883e-9 1.64813097502e-9 0.09986513009930609 0.40699751134811535 1.3826677581480062 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Hypothalamic Dopaminergic Neurons 0.061 0.0288 0.017189 0.10458659154929577 1.3826677581480062 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) interneurons 1.83904396564e-9 1.26275507215e-9 0.07264459555331271 0.3374458632153881 1.3740632385934255 MAGMA Top 10% Neuroticism (Nagel et al., 2018) interneurons 0.0591 0.03 0.024585 0.12494964705882351 1.3740632385934255 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Radial glia like cells 4.14569476229e-9 2.9729248334e-9 0.08158581747037685 0.3470096842912694 1.3666873252446847 MAGMA Top 10% Migraine (Gormley et al., 2016) Radial glia like cells 0.0505 0.0252 0.022647 0.1178735421686747 1.3666873252446847 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Serotonergic Neuron 4.44778778417e-9 1.83553847385e-9 0.007693254467349586 0.08982394405121678 1.364669685369733 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Serotonergic Neuron 0.0208 0.0298 0.24241 0.5540799999999999 1.364669685369733 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) endothelial-mural 5.73619596853e-9 2.85700092122e-9 0.02233395785246961 0.18204282626918625 1.3603865785108327 MAGMA Top 10% Migraine (Gormley et al., 2016) endothelial-mural 0.0349 0.0254 0.085165 0.3117905084745763 1.3603865785108327 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) pyramidal SS 1.62902825114e-9 8.88478211786e-10 0.033363835832275535 0.23247059805714565 1.3404393760173756 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) pyramidal SS 0.0436 0.0284 0.062495 0.2595946153846154 1.3404393760173756 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Neuroblasts 1.71592683297e-8 7.0204890043e-9 0.007259292554123387 0.08960041095375151 1.329988431199618 MAGMA Top 10% Bipolar (Stahl et al., 2018) Neuroblasts 0.014 0.0269 0.30139 0.6273553846153846 1.329988431199618 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Dopaminergic Neuroblast 4.27929108734e-9 1.68538515107e-9 0.005557565620472493 0.07061377494247403 1.3229099359152385 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Dopaminergic Neuroblast 0.00681 0.0289 0.40672 0.734848132780083 1.3229099359152385 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) interneurons 2.90882145388e-9 2.41499915718e-9 0.11420179239810646 0.4404926278212678 1.3206159724150686 MAGMA Top 10% Age at menarche (Perry et al., 2014) interneurons 0.0609 0.0296 0.020003 0.11078584615384615 1.3206159724150686 LDSC Top 10% (Z P) Autism (Grove et al., 2017) interneurons 3.84258688635e-9 5.21522584482e-9 0.23062149689545308 0.5860499215225631 1.314932337883107 MAGMA Top 10% Autism (Grove et al., 2017) interneurons 0.0604 0.026 0.010168 0.07200944262295082 1.314932337883107 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Embryonic Dopaminergic Neuron 8.76819763121e-10 1.38584687385e-9 0.2634660937322375 0.6288251518913073 1.3099857344256363 MAGMA Top 10% Educational attainment (Lee et al., 2018) Embryonic Dopaminergic Neuron 0.0913 0.0387 0.0091055 0.06555960000000001 1.3099857344256363 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Striatal Interneuron 7.70643647456e-10 8.59475599194e-10 0.1849544531307854 0.5167859760350141 1.3051303472747762 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Striatal Interneuron 0.0621 0.028 0.013264 0.09095314285714284 1.3051303472747762 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Dopaminergic Adult 2.72358474382e-9 2.77279332668e-9 0.1629875954249811 0.5051233741244823 1.2948004305841496 MAGMA Top 10% BMI (Yengo et al., 2018) Dopaminergic Adult 0.0974 0.0453 0.015785 0.10167652173913044 1.2948004305841496 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Serotonergic Neuron 5.64142629663e-9 5.15998808437e-9 0.13713056983179472 0.4656304220097796 1.284685287924882 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Serotonergic Neuron 0.0708 0.0344 0.019656 0.11027781818181819 1.284685287924882 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Neuroblasts 1.08582234858e-8 1.18446053305e-8 0.17964387534590465 0.5167859760350141 1.236977523627822 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Neuroblasts 0.0532 0.0256 0.018691 0.10766015999999999 1.236977523627822 LDSC Top 10% (Z P) Autism (Grove et al., 2017) pyramidal SS 4.69536728586e-9 5.23994792487e-9 0.1851073249077566 0.5167859760350141 1.236455428324954 MAGMA Top 10% Autism (Grove et al., 2017) pyramidal SS 0.0537 0.0257 0.018183 0.10766015999999999 1.236455428324954 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Serotonergic Neuron 9.08914501981e-9 5.42933613644e-9 0.04705740307678452 0.29462026274160746 1.2327366921918959 MAGMA Top 10% Autism (Grove et al., 2017) Serotonergic Neuron 0.0378 0.026 0.072761 0.28575229090909093 1.2327366921918959 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Embryonic GABAergic Neuron 9.20393532857e-10 8.08613298946e-10 0.12751077732406269 0.4515135721638941 1.2199870612293422 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Embryonic GABAergic Neuron 0.0527 0.0277 0.028476 0.13979127272727274 1.2199870612293422 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Embryonic midbrain nucleus neurons 1.92661175618e-9 2.64379145433e-9 0.2330832327349458 0.587452880663805 1.1809167090819725 MAGMA Top 10% BMI (Yengo et al., 2018) Embryonic midbrain nucleus neurons 0.0915 0.0439 0.018649 0.10766015999999999 1.1809167090819725 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Embryonic midbrain nucleus neurons 1.52066128986e-8 6.53951736561e-9 0.010026846176802828 0.1056487206921664 1.1578312420146906 MAGMA Top 10% Bipolar (Stahl et al., 2018) Embryonic midbrain nucleus neurons 0.00122 0.0273 0.48214 0.7780954838709677 1.1578312420146906 LDSC Top 10% (Z P) Parkinson's disease (this study) Embryonic Dopaminergic Neuron 2.03591704201e-9 1.42815157575e-9 0.07699756504852984 0.3458234557377656 1.1388655039674553 MAGMA Top 10% Parkinson's disease (this study) Embryonic Dopaminergic Neuron 0.0392 0.0264 0.068516 0.274484 1.1388655039674553 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Serotonergic Neuron 1.12894963886e-9 1.05023262447e-9 0.14119811408166927 0.4656304220097796 1.1251876679957287 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Serotonergic Neuron 0.0486 0.0277 0.039792 0.18094888421052632 1.1251876679957287 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Dopaminergic Neuroblast 1.15325691447e-8 5.91519374034e-9 0.025608807145888313 0.2011455397640682 1.121837985896097 MAGMA Top 10% Autism (Grove et al., 2017) Dopaminergic Neuroblast 0.0194 0.0254 0.22281 0.5339235164835164 1.121837985896097 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Dopaminergic Neuroblast 1.32217848131e-8 1.14064599594e-8 0.12319776073074296 0.4435119386306747 1.082606884194436 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Dopaminergic Neuroblast 0.0404 0.0254 0.055486 0.23499952941176472 1.082606884194436 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Embryonic midbrain nucleus neurons 1.7808291602e-9 2.45264496118e-9 0.233893276560589 0.587452880663805 1.0684764817217722 MAGMA Top 10% Intelligence (Savage et al., 2018) Embryonic midbrain nucleus neurons 0.0623 0.0334 0.031191 0.15032159999999997 1.0684764817217722 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Medium Spiny Neuron 3.03332803432e-9 8.44975013108e-9 0.3598033995275425 0.7360605708959742 1.0623935106875346 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Medium Spiny Neuron 0.0544 0.0267 0.020852 0.11272500000000002 1.0623935106875346 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) interneurons 6.61762289585e-10 2.44472987537e-9 0.39331499236356027 0.7537057281533813 1.0602114306072001 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) interneurons 0.0516 0.0249 0.019268 0.10952336842105263 1.0602114306072001 LDSC Top 10% (Z P) Parkinson's disease (this study) pyramidal CA1 8.68904158426e-10 8.60668608297e-10 0.1563509663045768 0.5034539128803687 1.041242404425517 MAGMA Top 10% Parkinson's disease (this study) pyramidal CA1 0.0448 0.0277 0.052895 0.2262439603960396 1.041242404425517 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Hypothalamic Glutamatergic Neurons 1.59238910893e-9 1.14380378021e-9 0.0819328421243275 0.3470096842912694 1.0358217964626102 MAGMA Top 10% Educational attainment (Lee et al., 2018) Hypothalamic Glutamatergic Neurons 0.0508 0.0403 0.10349 0.3520289763779528 1.0358217964626102 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Serotonergic Neuron 3.69123888585e-9 2.87507430323e-9 0.09959267361301194 0.40699751134811535 1.0273950407237114 MAGMA Top 10% Age at menarche (Perry et al., 2014) Serotonergic Neuron 0.0397 0.0294 0.088508 0.3134053770491803 1.0273950407237114 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Striatal Interneuron 1.43413973061e-8 8.81200880199e-9 0.05181724459553416 0.3117671163550353 1.010495594727728 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Striatal Interneuron 0.0231 0.0257 0.18388 0.48733840490797536 1.010495594727728 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Striatal Interneuron 9.68493313007e-10 1.29202681135e-9 0.22675015331025916 0.5796216936688282 1.009451661683689 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Striatal Interneuron 0.0516 0.0299 0.042223 0.185664 1.009451661683689 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Radial glia like cells 8.260642426e-9 1.18391437341e-8 0.2426699495254021 0.5956444215623506 0.9930524248133816 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Radial glia like cells 0.0443 0.0257 0.042548 0.185664 0.9930524248133816 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Neural Progenitors 5.48601688096e-9 3.20480311425e-9 0.04346576198835328 0.2761354291024796 0.9844548300572813 MAGMA Top 10% Migraine (Gormley et al., 2016) Neural Progenitors 0.0172 0.0252 0.24714 0.5591025 0.9844548300572813 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Dopaminergic Neuroblast 1.02122669603e-9 6.75065412388e-10 0.06516754169295602 0.33464488195280323 0.9777215533562844 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Dopaminergic Neuroblast 0.0225 0.0236 0.17003 0.4721538461538462 0.9777215533562844 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Neuroblasts 1.91024057582e-9 5.37772854967e-9 0.3612149097915429 0.7360605708959742 0.9685150349847222 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Neuroblasts 0.0611 0.033 0.032004 0.15121878260869567 0.9685150349847222 LDSC Top 10% (Z P) Anorexia (PGC, 2018) pyramidal SS 5.81023861356e-9 4.05415138924e-9 0.07590637578174475 0.3458234557377656 0.9644709864661414 MAGMA Top 10% Anorexia (PGC, 2018) pyramidal SS 0.0271 0.0267 0.15516 0.44919359999999997 0.9644709864661414 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Vascular Leptomeningeal Cells 2.6889421369e-9 2.30400745225e-9 0.12159068642875936 0.4420747909327217 0.9292307961917547 MAGMA Top 10% Migraine (Gormley et al., 2016) Vascular Leptomeningeal Cells 0.031 0.0257 0.11393 0.3775870588235294 0.9292307961917547 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Hypothalamic Dopaminergic Neurons 3.74584841301e-9 3.18506166767e-9 0.11978389544034052 0.4420747909327217 0.923264652406359 MAGMA Top 10% Age at menarche (Perry et al., 2014) Hypothalamic Dopaminergic Neurons 0.0338 0.0286 0.11887 0.3775870588235294 0.923264652406359 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Neural Progenitors 1.2193704052e-8 1.04563029148e-8 0.12177523176155991 0.4420747909327217 0.9228308361001858 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Neural Progenitors 0.0296 0.0249 0.11716 0.3775870588235294 0.9228308361001858 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Hypothalamic Glutamatergic Neurons 5.31242630398e-9 5.52464053607e-9 0.16812837999313968 0.5079123087904639 0.9088695932088093 MAGMA Top 10% ADHD (Demontis et al., 2017) Hypothalamic Glutamatergic Neurons 0.0361 0.027 0.090494 0.3178325853658537 0.9088695932088093 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Embryonic GABAergic Neuron 6.30884516206e-10 5.49725010714e-10 0.12555931675246523 0.44827789121541306 0.9083410123740139 MAGMA Top 10% Stroke (Malik et al., 2018) Embryonic GABAergic Neuron 0.0292 0.025 0.12147 0.3830294890510949 0.9083410123740139 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Neural Progenitors 5.74280740028e-9 5.72485339293e-9 0.15789758703352463 0.5034539128803687 0.8956198676318208 MAGMA Top 10% Autism (Grove et al., 2017) Neural Progenitors 0.0319 0.0252 0.10242 0.3511542857142857 0.8956198676318208 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Serotonergic Neuron 5.457508208e-9 7.04217625015e-9 0.2191773139664026 0.57038915441859 0.8955799037581187 MAGMA Top 10% Bipolar (Stahl et al., 2018) Serotonergic Neuron 0.0402 0.0278 0.073798 0.2872138378378379 0.8955799037581187 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Hypothalamic GABAergic Neurons 4.13552185542e-10 9.66336237881e-10 0.3343405247440774 0.7080152288698109 0.8945605488493665 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Hypothalamic GABAergic Neurons 0.0464 0.0279 0.048606 0.20997792000000004 0.8945605488493665 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Dopaminergic Adult 1.16181858585e-8 6.69590045196e-9 0.04135984149849459 0.26667838100521885 0.8697819813432969 MAGMA Top 10% Bipolar (Stahl et al., 2018) Dopaminergic Adult 0.00416 0.0278 0.44041 0.7608019123505976 0.8697819813432969 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Dopaminergic Neuroblast 5.27084524276e-9 3.59135615982e-9 0.07109998579509746 0.33464488195280323 0.8692339123962316 MAGMA Top 10% Age at menarche (Perry et al., 2014) Dopaminergic Neuroblast 0.0187 0.0286 0.25684 0.5731125773195876 0.8692339123962316 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Embryonic GABAergic Neuron 4.674998672e-9 4.34468392321e-9 0.14095751530927647 0.4656304220097796 0.858335444163622 MAGMA Top 10% Anorexia (PGC, 2018) Embryonic GABAergic Neuron 0.0289 0.0263 0.13622 0.4145374647887324 0.858335444163622 LDSC Top 10% (Z P) Parkinson's disease (this study) astrocytes_ependymal 2.26137888568e-10 5.65800472776e-10 0.34469692243251093 0.7219649784664242 0.8527579818084919 MAGMA Top 10% Parkinson's disease (this study) astrocytes_ependymal 0.0414 0.0262 0.057154 0.23971386407766992 0.8527579818084919 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Hypothalamic Glutamatergic Neurons 8.08134480058e-10 4.96968472261e-10 0.05196118605917255 0.3117671163550353 0.8495203691806503 MAGMA Top 10% Stroke (Malik et al., 2018) Hypothalamic Glutamatergic Neurons 0.00729 0.0249 0.38484 0.7121014468085106 0.8495203691806503 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Radial glia like cells 1.69536404165e-8 1.11925646189e-8 0.06492122298683833 0.33464488195280323 0.8392390093222548 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Radial glia like cells 0.0113 0.0246 0.32295 0.6519364485981308 0.8392390093222548 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Hypothalamic GABAergic Neurons 1.02150783177e-9 1.35332312418e-9 0.2251801651862808 0.5790347104790079 0.837617309705162 MAGMA Top 10% Educational attainment (Lee et al., 2018) Hypothalamic GABAergic Neurons 0.053 0.0402 0.093807 0.324321408 0.837617309705162 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Embryonic midbrain nucleus neurons 2.82314796586e-9 1.56319596945e-9 0.03545836814612047 0.23934398498631315 0.8342808870880551 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Embryonic midbrain nucleus neurons -0.00768 0.0289 0.60495 0.8430270967741935 0.8342808870880551 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Dopaminergic Adult 8.15054334998e-9 5.75778112244e-9 0.07845069134791904 0.3458234557377656 0.831359841533473 MAGMA Top 10% ADHD (Demontis et al., 2017) Dopaminergic Adult 0.0161 0.0272 0.27713 0.6053018181818182 0.831359841533473 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Dopaminergic Neuroblast 6.70379147373e-9 6.19236503689e-9 0.13949525950471542 0.4656304220097796 0.831199739351277 MAGMA Top 10% ADHD (Demontis et al., 2017) Dopaminergic Neuroblast 0.0265 0.0262 0.15597 0.44919359999999997 0.831199739351277 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Oligodendrocytes -2.65400587501e-10 5.28884157439e-9 0.5200110164071385 0.8599144731489894 0.8305863385685897 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Oligodendrocytes 0.0589 0.0341 0.041958 0.185664 0.8305863385685897 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Hypothalamic GABAergic Neurons 2.53572255672e-9 2.16243644748e-9 0.1204735255573296 0.4420747909327217 0.8283998527285478 MAGMA Top 10% Intelligence (Savage et al., 2018) Hypothalamic GABAergic Neurons 0.0293 0.0324 0.18294 0.48733840490797536 0.8283998527285478 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Neuroblasts 1.70564473665e-8 1.16313529936e-8 0.07126696560105994 0.33464488195280323 0.8244212708615527 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Neuroblasts 0.012 0.0249 0.31497000000000003 0.6448674881516587 0.8244212708615527 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Medium Spiny Neuron 9.00453344023e-10 5.17430198116e-10 0.04090833783483949 0.26667838100521885 0.8206797172075074 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Medium Spiny Neuron -0.00365 0.0249 0.55825 0.8141818181818181 0.8206797172075074 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Hypothalamic GABAergic Neurons 5.67168002587e-9 3.20555108489e-9 0.038419349416014104 0.2553409068879707 0.819679642141979 MAGMA Top 10% Age at menarche (Perry et al., 2014) Hypothalamic GABAergic Neurons -0.00713 0.029 0.59716 0.8430270967741935 0.819679642141979 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Embryonic Dopaminergic Neuron 2.47412398284e-9 1.68691597301e-9 0.07123494598152469 0.33464488195280323 0.8170046882404777 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Embryonic Dopaminergic Neuron 0.0132 0.0292 0.32606 0.6531362211981566 0.8170046882404777 LDSC Top 10% (Z P) Parkinson's disease (this study) Oligodendrocytes 6.29579964e-10 6.64210151393e-10 0.17159970227804766 0.5093260653369163 0.8103768145769996 MAGMA Top 10% Parkinson's disease (this study) Oligodendrocytes 0.0291 0.0269 0.13955 0.42157762237762236 0.8103768145769996 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Hypothalamic GABAergic Neurons 8.66445883199e-9 9.63277896076e-9 0.1841994392216607 0.5167859760350141 0.8043063865091835 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Hypothalamic GABAergic Neurons 0.028 0.0253 0.13369 0.41252914285714287 0.8043063865091835 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Dopaminergic Adult 6.87773714735e-10 1.28429212784e-9 0.29614258355927114 0.6560697235774623 0.801353814208453 MAGMA Top 10% Educational attainment (Lee et al., 2018) Dopaminergic Adult 0.0546 0.0396 0.084293 0.3112356923076923 0.801353814208453 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Striatal Interneuron -1.0442429851e-9 1.7534690078e-9 0.7242552953040251 0.9932831051614757 0.7993519140996911 MAGMA Top 10% Migraine (Gormley et al., 2016) Striatal Interneuron 0.0472 0.026 0.034786 0.1615865806451613 0.7993519140996911 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Striatal Interneuron -1.54187747814e-9 2.58890808429e-9 0.7242689308469094 0.9932831051614757 0.7966553964060139 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Striatal Interneuron 0.0453 0.0251 0.03522 0.1618621276595745 0.7966553964060139 LDSC Top 10% (Z P) Parkinson's disease (this study) pyramidal SS 1.3584915218e-9 8.89096500316e-10 0.06326296166957435 0.33464488195280323 0.7935954438500685 MAGMA Top 10% Parkinson's disease (this study) pyramidal SS 0.00638 0.0277 0.40894 0.734848132780083 0.7935954438500685 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Embryonic midbrain nucleus neurons 5.1910644073e-9 5.46474217267e-9 0.1710766134823093 0.5093260653369163 0.7897853677502057 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Embryonic midbrain nucleus neurons 0.0342 0.0335 0.1539 0.44919359999999997 0.7897853677502057 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Dopaminergic Adult 2.372800041e-9 2.14322536618e-9 0.13412179392009715 0.46352491978785576 0.786159175867839 MAGMA Top 10% Intelligence (Savage et al., 2018) Dopaminergic Adult 0.0279 0.0331 0.19961 0.5163564071856288 0.786159175867839 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) microglia 1.38486713222e-9 1.04603173944e-9 0.09276404682699557 0.3890686235850688 0.7860040435052322 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) microglia 0.0135 0.0242 0.28881 0.6146104433497538 0.7860040435052322 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Striatal Interneuron 3.96861862588e-9 3.95400710944e-9 0.15776273488960002 0.5034539128803687 0.7851355951572081 MAGMA Top 10% Anorexia (PGC, 2018) Striatal Interneuron 0.0257 0.027 0.1705 0.4721538461538462 0.7851355951572081 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Oxytocin / Vasopressin Expressing Neurons 2.30904174565e-10 8.78121405363e-10 0.39629361469815094 0.7541799187207101 0.7827629412750317 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Oxytocin / Vasopressin Expressing Neurons 0.0417 0.0281 0.068621 0.274484 0.7827629412750317 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Embryonic midbrain nucleus neurons 6.4873056684e-9 9.02321329776e-9 0.2360835943181987 0.5895266632685655 0.7793184931965624 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Embryonic midbrain nucleus neurons 0.0297 0.0249 0.11703 0.3775870588235294 0.7793184931965624 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Embryonic midbrain nucleus neurons 1.11816262091e-9 9.47454637011e-10 0.11896523767298617 0.4420747909327217 0.7756500150696641 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Embryonic midbrain nucleus neurons 0.0199 0.0277 0.2362 0.5493792513368984 0.7756500150696641 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Neuroblasts 5.48198952031e-9 5.01176690706e-9 0.13701614949359842 0.4656304220097796 0.7685179016549695 MAGMA Top 10% Anorexia (PGC, 2018) Neuroblasts 0.021 0.0262 0.21193 0.5220081818181819 0.7685179016549695 LDSC Top 10% (Z P) Parkinson's disease (this study) Embryonic GABAergic Neuron 7.44269340974e-10 4.88013971966e-10 0.06361727476324042 0.33464488195280323 0.763954283652521 MAGMA Top 10% Parkinson's disease (this study) Embryonic GABAergic Neuron 0.00225 0.0265 0.46614 0.768597251908397 0.763954283652521 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Embryonic Dopaminergic Neuron 9.16959937857e-9 6.46780447289e-9 0.07813482780534986 0.3458234557377656 0.7631835860742492 MAGMA Top 10% ADHD (Demontis et al., 2017) Embryonic Dopaminergic Neuron 0.00805 0.0265 0.38088 0.7121014468085106 0.7631835860742492 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Dopaminergic Adult 2.83987318674e-9 3.32981139914e-9 0.19686762048302886 0.5315425753041779 0.7614203704705863 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Dopaminergic Adult 0.0256 0.0249 0.1524 0.44919359999999997 0.7614203704705863 LDSC Top 10% (Z P) Parkinson's disease (this study) Embryonic midbrain nucleus neurons 1.97478648671e-10 5.04063240453e-10 0.34761276740975977 0.7219649784664242 0.7575293559818801 MAGMA Top 10% Parkinson's disease (this study) Embryonic midbrain nucleus neurons 0.0353 0.0261 0.087871 0.3134053770491803 0.7575293559818801 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Neuroblasts 6.20999381079e-9 7.04439109409e-9 0.18900968567947274 0.5167859760350141 0.7534375408951812 MAGMA Top 10% ADHD (Demontis et al., 2017) Neuroblasts 0.0256 0.0262 0.16468 0.4680378947368421 0.7534375408951812 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Dopaminergic Adult 1.10449950989e-9 8.91633067895e-9 0.4507076101084606 0.8146681488152928 0.7336624408381239 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Dopaminergic Adult 0.0368 0.0256 0.075645 0.29177357142857147 0.7336624408381239 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Oligodendrocytes 1.04063160836e-9 1.92330013455e-9 0.2942311718996453 0.6560697235774623 0.7325859127970717 MAGMA Top 10% Migraine (Gormley et al., 2016) Oligodendrocytes 0.0307 0.0257 0.11645 0.3775870588235294 0.7325859127970717 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Hypothalamic Glutamatergic Neurons 6.16344156876e-10 9.66137018508e-10 0.2617541094232908 0.6287860930023618 0.7238690533808468 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Hypothalamic Glutamatergic Neurons 0.0306 0.0279 0.13626 0.4145374647887324 0.7238690533808468 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Embryonic midbrain nucleus neurons 7.22404317314e-10 6.14526600701e-10 0.11988816277543812 0.4420747909327217 0.7215523550073097 MAGMA Top 10% Stroke (Malik et al., 2018) Embryonic midbrain nucleus neurons 0.013 0.0249 0.30069 0.6273553846153846 0.7215523550073097 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) pyramidal SS 9.84929721557e-9 9.236780745e-9 0.14314114052305726 0.4684619144390965 0.7146227377219289 MAGMA Top 10% Intracranial volume (Adams et al., 2016) pyramidal SS 0.0167 0.026 0.26001 0.576022153846154 0.7146227377219289 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) pyramidal CA1 6.09801010201e-9 8.60221510941e-9 0.23919688162779895 0.5904745877897665 0.7143385165695841 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) pyramidal CA1 0.0256 0.0253 0.1558 0.44919359999999997 0.7143385165695841 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Embryonic Dopaminergic Neuron 3.97006646747e-10 8.73951686055e-10 0.32481864689320317 0.6912396820584422 0.7098269137204919 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Embryonic Dopaminergic Neuron 0.0328 0.0276 0.11714 0.3775870588235294 0.7098269137204919 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Embryonic midbrain nucleus neurons 1.43405325172e-8 1.00280743221e-8 0.07635298253656131 0.3458234557377656 0.7096324813864104 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Embryonic midbrain nucleus neurons 7.88e-5 0.0258 0.49878 0.7780954838709677 0.7096324813864104 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Neuroblasts 2.84191922163e-9 3.13914788972e-9 0.18264913526489768 0.5167859760350141 0.7087132213362384 MAGMA Top 10% Age at menarche (Perry et al., 2014) Neuroblasts 0.0232 0.0287 0.20939 0.5198648275862069 0.7087132213362384 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Hypothalamic Dopaminergic Neurons 7.8677173524e-10 5.32467473124e-10 0.06975799122700255 0.33464488195280323 0.7042059658622466 MAGMA Top 10% Stroke (Malik et al., 2018) Hypothalamic Dopaminergic Neurons -0.00375 0.0249 0.55975 0.8141818181818181 0.7042059658622466 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) endothelial-mural 1.96217275609e-10 3.14006886739e-9 0.47508702623618826 0.8368862346672908 0.6895152454887546 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) endothelial-mural 0.0334 0.0247 0.087942 0.3134053770491803 0.6895152454887546 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) pyramidal CA1 6.63796163409e-9 9.94046645756e-9 0.2521396846144639 0.6153917726183527 0.678979664497332 MAGMA Top 10% Intracranial volume (Adams et al., 2016) pyramidal CA1 0.0248 0.0264 0.17394 0.4755827848101266 0.678979664497332 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Oligodendrocyte Precursor 3.70978462436e-9 2.639201467e-9 0.07991454242414309 0.3470096842912694 0.6760637910783585 MAGMA Top 10% Migraine (Gormley et al., 2016) Oligodendrocyte Precursor -0.0036 0.0254 0.55622 0.8141818181818181 0.6760637910783585 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) microglia 1.77489828599e-10 6.40111815917e-10 0.39078278303412717 0.7537057281533813 0.6668069297828396 MAGMA Top 10% Stroke (Malik et al., 2018) microglia 0.0292 0.0247 0.1187 0.3775870588235294 0.6668069297828396 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Dopaminergic Adult 5.54890942877e-9 6.28974996315e-9 0.18883037627155108 0.5167859760350141 0.6643096126948013 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Dopaminergic Adult 0.0232 0.0341 0.24849 0.5591025 0.6643096126948013 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Hypothalamic GABAergic Neurons -2.50630734227e-9 5.22671141889e-9 0.6842152664365364 0.9691180167232253 0.6607996930907839 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Hypothalamic GABAergic Neurons 0.0511 0.0346 0.069696 0.2762263486238532 0.6607996930907839 LDSC Top 10% (Z P) Anorexia (PGC, 2018) interneurons 3.87037505802e-9 4.18365008315e-9 0.17745195094434518 0.5167859760350141 0.6515628620776059 MAGMA Top 10% Anorexia (PGC, 2018) interneurons 0.0155 0.0267 0.28041 0.6087292462311558 0.6515628620776059 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Dopaminergic Neuroblast -1.78266539279e-9 5.51134269403e-9 0.6268242496208412 0.9557572182451216 0.6501673047344733 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Dopaminergic Neuroblast 0.0467 0.0332 0.079895 0.30276 0.6501673047344733 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Serotonergic Neuron -7.38922572986e-10 1.73659168262e-9 0.6647644792838907 0.9691180167232253 0.6461014431448375 MAGMA Top 10% Migraine (Gormley et al., 2016) Serotonergic Neuron 0.0369 0.0258 0.076759 0.29345033628318584 0.6461014431448375 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Dopaminergic Adult 2.9835559648e-9 4.82092799226e-9 0.26799907071601736 0.6361296623588983 0.6303426127235845 MAGMA Top 10% Autism (Grove et al., 2017) Dopaminergic Adult 0.0213 0.0259 0.20473 0.5187536842105263 0.6303426127235845 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) pyramidal SS 4.27755148584e-9 7.36476369972e-9 0.28068320108334177 0.6543657027892478 0.6209277343597371 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) pyramidal SS 0.0211 0.0255 0.20414 0.5187536842105263 0.6209277343597371 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Neuroblasts 6.26867373907e-10 6.40282043274e-10 0.16377793093390114 0.5051233741244823 0.6196256553797925 MAGMA Top 10% Stroke (Malik et al., 2018) Neuroblasts 0.00947 0.0249 0.35196 0.6818238565022422 0.6196256553797925 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Hypothalamic GABAergic Neurons -6.38511601128e-10 1.38098416223e-9 0.6780883491799381 0.9691180167232253 0.6149244477115969 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Hypothalamic GABAergic Neurons 0.0398 0.0292 0.086869 0.3134053770491803 0.6149244477115969 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Neural Progenitors 5.9799989453e-9 6.06207852412e-9 0.16195367828660323 0.5051233741244823 0.6055442646375935 MAGMA Top 10% ADHD (Demontis et al., 2017) Neural Progenitors 0.00801 0.0262 0.37977 0.7121014468085106 0.6055442646375935 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) interneurons 3.34547778396e-9 9.01443272812e-9 0.355272362804848 0.7308460034842587 0.5881375986171219 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) interneurons 0.0227 0.0256 0.18757 0.49408682926829267 0.5881375986171219 LDSC Top 10% (Z P) Parkinson's disease (this study) Oxytocin / Vasopressin Expressing Neurons 4.23252213098e-10 5.02483151011e-10 0.1998040924679746 0.5361202978022672 0.5835818640252295 MAGMA Top 10% Parkinson's disease (this study) Oxytocin / Vasopressin Expressing Neurons 0.0108 0.0264 0.34059 0.6690698181818181 0.5835818640252295 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Neural Progenitors -1.33304423251e-9 1.19841882434e-9 0.8670031143145654 0.9999999952766544 0.576924168731065 MAGMA Top 10% Educational attainment (Lee et al., 2018) Neural Progenitors 0.0546 0.0391 0.080934 0.3028506206896552 0.576924168731065 LDSC Top 10% (Z P) Parkinson's disease (this study) Oligodendrocyte Precursor 1.11977019025e-10 5.28316496538e-10 0.41607277187192193 0.7747561958994408 0.5706279833825032 MAGMA Top 10% Parkinson's disease (this study) Oligodendrocyte Precursor 0.0256 0.0272 0.17361 0.4755827848101266 0.5706279833825032 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Dopaminergic Neuroblast 3.88440969382e-9 4.35829747548e-9 0.1863927907495333 0.5167859760350141 0.5668059802126854 MAGMA Top 10% Anorexia (PGC, 2018) Dopaminergic Neuroblast 0.00713 0.0266 0.39442 0.7219891525423728 0.5668059802126854 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Hypothalamic Glutamatergic Neurons -1.07758059703e-9 1.36473550146e-9 0.785116180649277 0.9999999952766544 0.5663320945439805 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Hypothalamic Glutamatergic Neurons 0.0388 0.0295 0.093843 0.324321408 0.5663320945439805 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) pyramidal SS 1.69663569711e-10 5.4906721866e-10 0.37865951712600343 0.7471847255314712 0.5623675648421176 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) pyramidal SS 0.0208 0.0246 0.19816 0.5156934939759036 0.5623675648421176 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Embryonic Dopaminergic Neuron 3.88521914023e-9 1.16883915371e-8 0.3697936905428042 0.7464994126845392 0.5618127519965772 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Embryonic Dopaminergic Neuron 0.0211 0.0254 0.20343 0.5187536842105263 0.5618127519965772 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Oxytocin / Vasopressin Expressing Neurons 1.8037779233e-9 3.15772569663e-9 0.2839229162691532 0.6543657027892478 0.5518230654864549 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Oxytocin / Vasopressin Expressing Neurons 0.0147 0.0249 0.27743 0.6053018181818182 0.5518230654864549 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Hypothalamic GABAergic Neurons 8.96076612091e-10 5.62913320279e-9 0.43676134775837216 0.8028974563047522 0.5490680629926289 MAGMA Top 10% Autism (Grove et al., 2017) Hypothalamic GABAergic Neurons 0.0231 0.0256 0.18265 0.48733840490797536 0.5490680629926289 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) interneurons 5.55217402516e-10 4.99595963729e-10 0.13321255383751462 0.46352491978785576 0.5410557767744382 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) interneurons -0.00755 0.0244 0.62136 0.8467745110410094 0.5410557767744382 LDSC Top 10% (Z P) Parkinson's disease (this study) Serotonergic Neuron 5.2537789161500005e-10 5.44083415269e-10 0.16711715237346025 0.5079123087904639 0.5379128110561782 MAGMA Top 10% Parkinson's disease (this study) Serotonergic Neuron -1.67e-4 0.0265 0.50252 0.7780954838709677 0.5379128110561782 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Radial glia like cells 1.90078524282e-10 5.93001110154e-10 0.3742808175663901 0.7471847255314712 0.5376383379940727 MAGMA Top 10% Stroke (Malik et al., 2018) Radial glia like cells 0.0186 0.0246 0.22466 0.5339235164835164 0.5376383379940727 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Embryonic GABAergic Neuron 5.90509431017e-9 6.6797672659e-9 0.18834083132202672 0.5167859760350141 0.5358443074117576 MAGMA Top 10% Bipolar (Stahl et al., 2018) Embryonic GABAergic Neuron 0.00343 0.0274 0.45016 0.7630510344827586 0.5358443074117576 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Neural Progenitors 4.53460658382e-11 8.56470038574e-10 0.47888774414602897 0.8375688480610709 0.5318732320217315 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Neural Progenitors 0.025 0.0274 0.18031 0.486837 0.5318732320217315 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Embryonic midbrain nucleus neurons 6.11146707743e-9 5.61063781472e-9 0.13801869098805641 0.4656304220097796 0.5309233266831827 MAGMA Top 10% ADHD (Demontis et al., 2017) Embryonic midbrain nucleus neurons -0.0086 0.0263 0.62837 0.8509587460815047 0.5309233266831827 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Dopaminergic Neuroblast 5.56822844281e-10 5.88751754579e-10 0.17213334615553189 0.5093260653369163 0.5236194594442686 MAGMA Top 10% Stroke (Malik et al., 2018) Dopaminergic Neuroblast -0.0013 0.0246 0.52107 0.7859690592334494 0.5236194594442686 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Oligodendrocyte Precursor -6.19814136807e-10 3.62960427845e-9 0.567796240485361 0.9074192361673905 0.5180792259999975 MAGMA Top 10% Anorexia (PGC, 2018) Oligodendrocyte Precursor 0.0265 0.0268 0.16205 0.4636132450331126 0.5180792259999975 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Embryonic midbrain nucleus neurons 5.02823095765e-9 4.44190932402e-9 0.12881770924380664 0.4524329300270282 0.5130089719044229 MAGMA Top 10% Anorexia (PGC, 2018) Embryonic midbrain nucleus neurons -0.0165 0.0268 0.73115 0.9107232276657061 0.5130089719044229 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Serotonergic Neuron 8.3489927497e-9 9.96481549189e-9 0.2010582632159389 0.536155368575837 0.5127526152889736 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Serotonergic Neuron 0.00201 0.0258 0.469 0.7698436363636364 0.5127526152889736 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Hypothalamic Dopaminergic Neurons 1.23118679085e-9 2.39188661101e-9 0.303369246917488 0.6593463576943686 0.5049986369662784 MAGMA Top 10% Intelligence (Savage et al., 2018) Hypothalamic Dopaminergic Neurons 0.0148 0.0321 0.32213 0.6519364485981308 0.5049986369662784 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Oligodendrocyte Precursor 3.33749069507e-9 6.00928984615e-9 0.2893144658165424 0.6543657027892478 0.4992315553120271 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Oligodendrocyte Precursor 0.0135 0.0342 0.34687 0.6753794594594594 0.4992315553120271 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Hypothalamic GABAergic Neurons 1.93298265296e-10 5.99192705131e-10 0.37349991938839455 0.7471847255314712 0.49777110906936817 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Hypothalamic GABAergic Neurons 0.0149 0.0244 0.2705 0.596204081632653 0.49777110906936817 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Oligodendrocyte Precursor -4.87693509294e-10 1.1963451917e-9 0.6582357156479268 0.9691180167232253 0.4969784270386221 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Oligodendrocyte Precursor 0.0295 0.029 0.15405 0.44919359999999997 0.4969784270386221 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) astrocytes_ependymal 6.39033092495e-10 2.77869738453e-9 0.409055295871002 0.766227798839058 0.4967518504002832 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) astrocytes_ependymal 0.0166 0.0244 0.24815 0.5591025 0.4967518504002832 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Hypothalamic Glutamatergic Neurons 2.05738061133e-9 2.26147521474e-9 0.1814767721590026 0.5167859760350141 0.49177001556086863 MAGMA Top 10% Intelligence (Savage et al., 2018) Hypothalamic Glutamatergic Neurons -0.00596 0.0327 0.57232 0.8241408 0.49177001556086863 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Hypothalamic Dopaminergic Neurons -7.42798610426e-12 6.04001672974e-10 0.5049060510157303 0.8487136733027062 0.4902312792261067 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Hypothalamic Dopaminergic Neurons 0.0195 0.0239 0.20717 0.5198648275862069 0.4902312792261067 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Radial glia like cells -6.00753899061e-9 3.22964886756e-9 0.9685658243189237 0.9999999952766544 0.48868086524682297 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Radial glia like cells 0.0299 0.0242 0.10877 0.364253023255814 0.48868086524682297 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Hypothalamic Glutamatergic Neurons 3.51006460122e-9 8.91137624851e-9 0.34683267571965437 0.7219649784664242 0.48598213112875277 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Hypothalamic Glutamatergic Neurons 0.0127 0.0252 0.30755 0.6336822857142856 0.48598213112875277 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) pyramidal CA1 4.4406513142e-11 4.28482718898e-10 0.4587288512757517 0.8222857417059117 0.4811069157972756 MAGMA Top 10% Stroke (Malik et al., 2018) pyramidal CA1 0.0181 0.0254 0.23781 0.5493792513368984 0.4811069157972756 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) pyramidal CA1 1.41475556568e-9 2.5059166954e-9 0.2861844711170898 0.6543657027892478 0.4801739860729334 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) pyramidal CA1 0.00747 0.0251 0.38283 0.7121014468085106 0.4801739860729334 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Medium Spiny Neuron -1.59066351736e-11 4.11541502749e-10 0.5154158197582673 0.8599144731489894 0.4800680123118113 MAGMA Top 10% Stroke (Malik et al., 2018) Medium Spiny Neuron 0.0209 0.0262 0.21267 0.5220081818181819 0.4800680123118113 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Oligodendrocyte Precursor 3.52005430915e-11 5.98764079471e-10 0.4765602169633184 0.8368862346672908 0.4759067272690477 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Oligodendrocyte Precursor 0.0174 0.024 0.23446 0.5493792513368984 0.4759067272690477 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Oligodendrocyte Precursor 6.70404392608e-9 1.05209420999e-8 0.2619942054176507 0.6287860930023618 0.47440796648288786 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Oligodendrocyte Precursor 0.00449 0.0253 0.42943 0.7535339271255062 0.47440796648288786 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Vascular Leptomeningeal Cells 4.80327537291e-10 6.17346318835e-10 0.2182691795620667 0.57038915441859 0.4739854465442531 MAGMA Top 10% Stroke (Malik et al., 2018) Vascular Leptomeningeal Cells -0.00103 0.025 0.51646 0.783269052631579 0.4739854465442531 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Hypothalamic Dopaminergic Neurons -2.08977538953e-9 1.92976067597e-9 0.8605779133194968 0.9999999952766544 0.473257648177206 MAGMA Top 10% Migraine (Gormley et al., 2016) Hypothalamic Dopaminergic Neurons 0.0288 0.0258 0.13143 0.4114330434782609 0.473257648177206 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Embryonic Dopaminergic Neuron -4.710658389e-9 5.53348624921e-9 0.8026987150710394 0.9999999952766544 0.4555341757829158 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Embryonic Dopaminergic Neuron 0.0343 0.0335 0.15289 0.44919359999999997 0.4555341757829158 LDSC Top 10% (Z P) Parkinson's disease (this study) Hypothalamic Glutamatergic Neurons 3.13954222791e-10 5.63003114454e-10 0.2885444109750144 0.6543657027892478 0.45273565810937716 MAGMA Top 10% Parkinson's disease (this study) Hypothalamic Glutamatergic Neurons 0.0047 0.027 0.43084 0.7535339271255062 0.45273565810937716 LDSC Top 10% (Z P) Parkinson's disease (this study) Striatal Interneuron -3.10607685372e-11 4.73850336073e-10 0.5261318495226344 0.8642165741208291 0.4524086253147771 MAGMA Top 10% Parkinson's disease (this study) Striatal Interneuron 0.0194 0.0271 0.23664 0.5493792513368984 0.4524086253147771 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) microglia 3.75559637919e-9 7.10132297207e-9 0.29845173960649785 0.6572814891353851 0.45110380605803707 MAGMA Top 10% ADHD (Demontis et al., 2017) microglia 0.00538 0.0265 0.41968 0.74304 0.45110380605803707 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Radial glia like cells 6.52953998376e-9 6.69936082822e-9 0.1648666568322963 0.5051233741244823 0.44753775520367234 MAGMA Top 10% ADHD (Demontis et al., 2017) Radial glia like cells -0.0194 0.026 0.77231 0.9332884679665739 0.44753775520367234 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Oligodendrocyte Precursor 1.66912784913e-9 6.04637899994e-9 0.39125324844038445 0.7537057281533813 0.4466432875981432 MAGMA Top 10% Autism (Grove et al., 2017) Oligodendrocyte Precursor 0.0115 0.0255 0.32678 0.6531362211981566 0.4466432875981432 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Oxytocin / Vasopressin Expressing Neurons -1.41276014458e-9 2.01547883334e-9 0.7583344782928036 0.9999999952766544 0.44624191804512586 MAGMA Top 10% Migraine (Gormley et al., 2016) Oxytocin / Vasopressin Expressing Neurons 0.0246 0.0256 0.16891 0.4721538461538462 0.44624191804512586 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Oligodendrocytes 1.9926779572e-9 3.51009940112e-9 0.2851198752255051 0.6543657027892478 0.4413482217690342 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Oligodendrocytes 0.00248 0.0244 0.45949 0.7630510344827586 0.4413482217690342 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Medium Spiny Neuron -2.06107685582e-9 2.58127664839e-9 0.7877016516565424 0.9999999952766544 0.439863578513367 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Medium Spiny Neuron 0.0246 0.0255 0.16746 0.4721538461538462 0.439863578513367 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Embryonic GABAergic Neuron 6.20537580621e-9 1.20794837273e-8 0.30372667866013736 0.6593463576943686 0.43602774436430697 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Embryonic GABAergic Neuron 0.00374 0.0257 0.44204 0.7608019123505976 0.43602774436430697 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Oligodendrocytes 6.54411022455e-10 7.98380960584e-10 0.2062013781944818 0.5464969041718781 0.43103234792922235 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Oligodendrocytes -0.0101 0.0236 0.66626 0.8682289156626506 0.43103234792922235 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Dopaminergic Neuroblast 6.39707158327e-9 6.42987747764e-9 0.15989296279648213 0.5041880286721189 0.42967519787496966 MAGMA Top 10% Bipolar (Stahl et al., 2018) Dopaminergic Neuroblast -0.0296 0.0269 0.86461 0.9933817021276596 0.42967519787496966 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) astrocytes_ependymal 1.87626594491e-10 6.80577931471e-10 0.39139418068079923 0.7537057281533813 0.42775443633282584 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) astrocytes_ependymal 0.00862 0.0234 0.35635 0.684192 0.42775443633282584 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Dopaminergic Neuroblast 1.15886753364e-10 1.06000444174e-8 0.49563858386977777 0.8463077795721106 0.4251627034326694 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Dopaminergic Neuroblast 0.0139 0.0245 0.28478 0.6110447524752475 0.4251627034326694 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Embryonic GABAergic Neuron -2.59408318829e-10 5.72198430267e-10 0.6748529920775211 0.9691180167232253 0.41931762542959916 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Embryonic GABAergic Neuron 0.0189 0.0239 0.21486 0.5236422471910113 0.41931762542959916 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Vascular Leptomeningeal Cells 4.37072559883e-9 4.9356579892e-9 0.18793256281983206 0.5167859760350141 0.41837615143585066 MAGMA Top 10% Anorexia (PGC, 2018) Vascular Leptomeningeal Cells -0.0198 0.0263 0.7749 0.9332884679665739 0.41837615143585066 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Embryonic Dopaminergic Neuron -2.87332397471e-10 6.30830831045e-10 0.6756189189346133 0.9691180167232253 0.41816363210439533 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Embryonic Dopaminergic Neuron 0.0185 0.0236 0.21576 0.5236422471910113 0.41816363210439533 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Neural Progenitors 2.74673334991e-9 3.60811755716e-9 0.22324942232795875 0.5775074876986718 0.41528410597350024 MAGMA Top 10% Age at menarche (Perry et al., 2014) Neural Progenitors -0.012 0.0287 0.66167 0.8682289156626506 0.41528410597350024 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Hypothalamic Dopaminergic Neurons 5.34324620329e-9 9.84441510793e-9 0.29364432985941846 0.6560697235774623 0.4094531499491153 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Hypothalamic Dopaminergic Neurons -0.00108 0.0258 0.51674 0.783269052631579 0.4094531499491153 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Vascular Leptomeningeal Cells 5.044923715e-9 1.24251568275e-8 0.34236213305778473 0.7214655681998196 0.4071278255168282 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Vascular Leptomeningeal Cells 0.00341 0.0261 0.44798 0.7630510344827586 0.4071278255168282 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Hypothalamic Dopaminergic Neurons -3.5415648154e-10 9.49918158113e-10 0.6453619235829362 0.9691180167232253 0.40473048208888673 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Hypothalamic Dopaminergic Neurons 0.0197 0.028 0.24029 0.5521557446808512 0.40473048208888673 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Hypothalamic GABAergic Neurons 6.78215892065e-9 9.55142328669e-9 0.2388310205206624 0.5904745877897665 0.3954615249409913 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Hypothalamic GABAergic Neurons -0.0121 0.0263 0.67762 0.8790745945945947 0.3954615249409913 LDSC Top 10% (Z P) Parkinson's disease (this study) Hypothalamic GABAergic Neurons -3.23156429036e-10 5.21675739443e-10 0.7321927969843754 0.999498178659075 0.3916539285205808 MAGMA Top 10% Parkinson's disease (this study) Hypothalamic GABAergic Neurons 0.0201 0.0266 0.22494 0.5339235164835164 0.3916539285205808 LDSC Top 10% (Z P) Parkinson's disease (this study) Neural Progenitors 7.87818721855e-10 1.00872694067e-9 0.21740037824402725 0.57038915441859 0.39055771226276015 MAGMA Top 10% Parkinson's disease (this study) Neural Progenitors -0.0187 0.0263 0.76142 0.9291905084745763 0.39055771226276015 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Embryonic Dopaminergic Neuron -9.82284480632e-10 8.85689841147e-9 0.5441546146161893 0.8771447519186335 0.38783528439609594 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Embryonic Dopaminergic Neuron 0.0124 0.0247 0.30804 0.6336822857142856 0.38783528439609594 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) pyramidal SS 5.69925703991e-11 2.86469148119e-9 0.49206363185890056 0.8435376546152581 0.3877841794913383 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) pyramidal SS 0.0104 0.0254 0.34073 0.6690698181818181 0.3877841794913383 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Hypothalamic GABAergic Neurons -4.2095125394e-9 2.73469451437e-9 0.9381343413716268 0.9999999952766544 0.3870894493652464 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Hypothalamic GABAergic Neurons 0.0228 0.0249 0.17929 0.486837 0.3870894493652464 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Oligodendrocyte Precursor 3.13436773396e-11 8.97634132936e-10 0.4860725243291355 0.8399333220407461 0.38644092565530136 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Oligodendrocyte Precursor 0.0109 0.0277 0.34707 0.6753794594594594 0.38644092565530136 LDSC Top 10% (Z P) Parkinson's disease (this study) endothelial-mural -1.49198612347e-10 8.55333275108e-10 0.5692375300957473 0.9074192361673905 0.38230662817359096 MAGMA Top 10% Parkinson's disease (this study) endothelial-mural 0.0138 0.0267 0.30206 0.6273553846153846 0.38230662817359096 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Oxytocin / Vasopressin Expressing Neurons 5.15560608394e-11 1.40061792599e-9 0.48531844528641 0.8399333220407461 0.3816767744466093 MAGMA Top 10% Educational attainment (Lee et al., 2018) Oxytocin / Vasopressin Expressing Neurons 0.0147 0.0396 0.35532 0.684192 0.3816767744466093 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Embryonic Dopaminergic Neuron 4.35705332787e-10 3.35234981525e-9 0.44829503050889885 0.8137119881506063 0.3801550458975077 MAGMA Top 10% Age at menarche (Perry et al., 2014) Embryonic Dopaminergic Neuron 0.00818 0.0286 0.38737 0.7121014468085106 0.3801550458975077 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Embryonic midbrain nucleus neurons -1.29478380649e-10 6.18195354151e-10 0.58294985369562 0.9217381639095459 0.3800398380968822 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Embryonic midbrain nucleus neurons 0.0127 0.0239 0.29805 0.6273553846153846 0.3800398380968822 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Oligodendrocytes -3.37976114469e-9 2.49963182674e-9 0.911828909073666 0.9999999952766544 0.37584045132673877 MAGMA Top 10% Intelligence (Savage et al., 2018) Oligodendrocytes 0.0279 0.0323 0.19427 0.5086341818181818 0.37584045132673877 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Hypothalamic GABAergic Neurons 3.03781145265e-9 5.44362363631e-9 0.28840529140266824 0.6543657027892478 0.37456037700098876 MAGMA Top 10% ADHD (Demontis et al., 2017) Hypothalamic GABAergic Neurons -0.00814 0.0272 0.61784 0.8467745110410094 0.37456037700098876 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Hypothalamic Glutamatergic Neurons -6.22593583337e-9 5.49662754327e-9 0.8713262720323545 0.9999999952766544 0.3736728166668109 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Hypothalamic Glutamatergic Neurons 0.0284 0.0345 0.20534 0.5187536842105263 0.3736728166668109 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Serotonergic Neuron 2.29829917664e-9 4.26536958645e-9 0.2950028829181438 0.6560697235774623 0.3728210154606504 MAGMA Top 10% Anorexia (PGC, 2018) Serotonergic Neuron -0.00753 0.0272 0.60888 0.845196923076923 0.3728210154606504 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Dopaminergic Neuroblast 1.27883517271e-9 2.20864918027e-9 0.2812904168824899 0.6543657027892478 0.3659765292785255 MAGMA Top 10% Migraine (Gormley et al., 2016) Dopaminergic Neuroblast -0.0105 0.0256 0.65901 0.8679643902439025 0.3659765292785255 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Oligodendrocyte Precursor 4.33520982282e-9 9.52200904762e-9 0.3244527904968417 0.6912396820584422 0.3646129808225542 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Oligodendrocyte Precursor -0.0049 0.0259 0.57494 0.8251630564784054 0.3646129808225542 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Serotonergic Neuron 1.88701986442e-10 5.38383169689e-10 0.362982661113342 0.7361901859200175 0.36115526003832144 MAGMA Top 10% Stroke (Malik et al., 2018) Serotonergic Neuron -0.00141 0.0253 0.52216 0.7859690592334494 0.36115526003832144 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Hypothalamic Glutamatergic Neurons -6.76410261944e-9 5.5362830042e-9 0.8891039945301487 0.9999999952766544 0.3559371764678086 MAGMA Top 10% Autism (Grove et al., 2017) Hypothalamic Glutamatergic Neurons 0.0199 0.0256 0.21836 0.5269917318435754 0.3559371764678086 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) interneurons -2.24513131349e-9 1.52809763108e-9 0.9291151851877061 0.9999999952766544 0.35567400120479997 MAGMA Top 10% Migraine (Gormley et al., 2016) interneurons 0.0211 0.026 0.20921 0.5198648275862069 0.35567400120479997 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) endothelial-mural 1.76217278151e-9 1.10234539079e-8 0.43649698562369776 0.8028974563047522 0.35285370795247906 MAGMA Top 10% Intracranial volume (Adams et al., 2016) endothelial-mural 0.00312 0.0254 0.45114 0.7630510344827586 0.35285370795247906 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Striatal Interneuron 1.22027854255e-10 4.7341253496e-10 0.39829522129835637 0.7546646298284647 0.3526957727670279 MAGMA Top 10% Stroke (Malik et al., 2018) Striatal Interneuron 3.35e-4 0.0256 0.49477 0.7780954838709677 0.3526957727670279 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Serotonergic Neuron -1.51841777244e-9 2.72269844505e-9 0.7114714642229276 0.9851143350778998 0.3477519850580254 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Serotonergic Neuron 0.0141 0.0245 0.28336 0.6110447524752475 0.3477519850580254 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Neural Progenitors 2.92686220075e-10 6.24383885525e-10 0.3196205800614561 0.6869457243111893 0.3422069997444085 MAGMA Top 10% Stroke (Malik et al., 2018) Neural Progenitors -0.00934 0.0248 0.64707 0.8574669938650307 0.3422069997444085 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Embryonic GABAergic Neuron 3.39382764686e-9 5.91478152003e-9 0.2830558073659535 0.6543657027892478 0.3419478945949523 MAGMA Top 10% ADHD (Demontis et al., 2017) Embryonic GABAergic Neuron -0.0163 0.0264 0.73153 0.9107232276657061 0.3419478945949523 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) microglia 8.41957231943e-10 8.72537305064e-9 0.4615636150329028 0.8239482714636942 0.33821615693131146 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) microglia 0.00274 0.025 0.45639 0.7630510344827586 0.33821615693131146 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Hypothalamic Dopaminergic Neurons 6.70150152842e-10 8.64661447554e-9 0.4691111692049317 0.8339754119198785 0.3325069403467127 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Hypothalamic Dopaminergic Neurons 0.00244 0.025 0.46101 0.7630510344827586 0.3325069403467127 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Hypothalamic Glutamatergic Neurons -4.77442478984e-9 2.59767781642e-9 0.9669657613731782 0.9999999952766544 0.3216219600989123 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Hypothalamic Glutamatergic Neurons 0.0178 0.0247 0.23515 0.5493792513368984 0.3216219600989123 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Oligodendrocyte Precursor -2.71664893199e-10 4.91464447467e-10 0.7097882128499218 0.9851143350778998 0.3201572829722159 MAGMA Top 10% Stroke (Malik et al., 2018) Oligodendrocyte Precursor 0.0116 0.0252 0.32252 0.6519364485981308 0.3201572829722159 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Hypothalamic Dopaminergic Neurons -5.80922668814e-9 5.6236040886e-9 0.8491998674749011 0.9999999952766544 0.30752472041449885 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Hypothalamic Dopaminergic Neurons 0.0193 0.0341 0.28572 0.6110447524752475 0.30752472041449885 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Oxytocin / Vasopressin Expressing Neurons -9.32480276467e-10 5.83880923741e-10 0.9448714299521641 0.9999999952766544 0.30703468000735484 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Oxytocin / Vasopressin Expressing Neurons 0.0157 0.0241 0.25737 0.5731125773195876 0.30703468000735484 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Neural Progenitors 5.02890101255e-10 7.81374566055e-10 0.25991849159209135 0.6287860930023618 0.30543612372857926 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Neural Progenitors -0.0371 0.0236 0.94252 0.99997 0.30543612372857926 LDSC Top 10% (Z P) Anorexia (PGC, 2018) astrocytes_ependymal -1.32384197981e-9 4.97517268878e-9 0.6049149186480467 0.9421522819478171 0.3054146176470854 MAGMA Top 10% Anorexia (PGC, 2018) astrocytes_ependymal 0.0062 0.0258 0.40502 0.734848132780083 0.3054146176470854 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Medium Spiny Neuron 1.2781524389e-9 8.77338706774e-9 0.4420849621798162 0.8073834708023307 0.29980169643063603 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Medium Spiny Neuron -0.00442 0.0256 0.56871 0.8216813377926422 0.29980169643063603 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Embryonic GABAergic Neuron 4.57954108606e-10 2.0062143092e-9 0.40971903132366294 0.766227798839058 0.29843493387436665 MAGMA Top 10% Migraine (Gormley et al., 2016) Embryonic GABAergic Neuron -0.00761 0.0254 0.61751 0.8467745110410094 0.29843493387436665 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Vascular Leptomeningeal Cells -7.55961029791e-9 1.0364831353e-8 0.7671068090187805 0.9999999952766544 0.29660443004478826 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Vascular Leptomeningeal Cells 0.0109 0.0251 0.33261 0.6591170642201836 0.29660443004478826 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Neuroblasts -6.35328911528e-11 7.00401372385e-10 0.5361381942686546 0.8674595502773738 0.2936534754411878 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Neuroblasts 0.00104 0.0236 0.48241 0.7780954838709677 0.2936534754411878 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Oxytocin / Vasopressin Expressing Neurons 2.3639632191e-9 1.02399905374e-8 0.4087133385479814 0.766227798839058 0.29359216979293956 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Oxytocin / Vasopressin Expressing Neurons -0.00877 0.0258 0.63299 0.8545365000000001 0.29359216979293956 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Radial glia like cells 2.87743582553e-10 6.22970816402e-9 0.4815798310128331 0.8388809959578383 0.29189469707822996 MAGMA Top 10% Autism (Grove et al., 2017) Radial glia like cells -0.00263 0.0252 0.54143 0.8010197260273971 0.29189469707822996 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Oligodendrocytes -8.76305836516e-9 1.04500211156e-8 0.7991442488558838 0.9999999952766544 0.2906975326865093 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Oligodendrocytes 0.0114 0.0256 0.32808 0.6531362211981566 0.2906975326865093 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Medium Spiny Neuron -1.3307807898e-10 1.51349345193e-9 0.5350329509886482 0.8674595502773738 0.29058321745208343 MAGMA Top 10% Migraine (Gormley et al., 2016) Medium Spiny Neuron 6.43e-4 0.0264 0.49029 0.7780954838709677 0.29058321745208343 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Oligodendrocyte Precursor -3.90126178062e-10 3.03329955213e-9 0.5511686372774942 0.8851481461110688 0.28544172187885525 MAGMA Top 10% Age at menarche (Perry et al., 2014) Oligodendrocyte Precursor 9.12e-4 0.0287 0.48734 0.7780954838709677 0.28544172187885525 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Oxytocin / Vasopressin Expressing Neurons 2.88261080385e-9 5.48891054494e-9 0.29973253092516405 0.6572814891353851 0.28186910390495257 MAGMA Top 10% ADHD (Demontis et al., 2017) Oxytocin / Vasopressin Expressing Neurons -0.0358 0.0266 0.91102 0.99997 0.28186910390495257 LDSC Top 10% (Z P) Parkinson's disease (this study) Vascular Leptomeningeal Cells -2.00274675788e-10 6.51678549443e-10 0.6207005741498941 0.950860454016859 0.2778520715341738 MAGMA Top 10% Parkinson's disease (this study) Vascular Leptomeningeal Cells 0.00348 0.0267 0.44814 0.7630510344827586 0.2778520715341738 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Hypothalamic GABAergic Neurons 1.22718239194e-9 3.9380635503e-9 0.3776643741468294 0.7471847255314712 0.2761923670843178 MAGMA Top 10% Anorexia (PGC, 2018) Hypothalamic GABAergic Neurons -0.0174 0.0268 0.74218 0.9186869914040113 0.2761923670843178 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) astrocytes_ependymal -5.42904198331e-9 1.1344776071e-8 0.6838705830668809 0.9691180167232253 0.275043349347741 MAGMA Top 10% Intracranial volume (Adams et al., 2016) astrocytes_ependymal 0.00567 0.0255 0.41204 0.735542479338843 0.275043349347741 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Striatal Interneuron 2.61126518277e-10 5.20586387434e-10 0.30797419863793807 0.6652242690579463 0.2728293087278434 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Striatal Interneuron -0.0352 0.0245 0.92433 0.99997 0.2728293087278434 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Dopaminergic Neuroblast -9.68132940796e-10 2.95692515493e-9 0.6283218749574411 0.9557572182451216 0.2693648363092025 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Dopaminergic Neuroblast 0.00239 0.024 0.46035 0.7630510344827586 0.2693648363092025 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Striatal Interneuron -1.85691537005e-9 8.68815998974e-9 0.5846209650722582 0.9217381639095459 0.2667046326538583 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Striatal Interneuron -5.65e-5 0.0264 0.50086 0.7780954838709677 0.2667046326538583 LDSC Top 10% (Z P) Parkinson's disease (this study) Hypothalamic Dopaminergic Neurons -1.5895908313e-10 5.89460567129e-10 0.6062924406979008 0.9421522819478171 0.2638846295514853 MAGMA Top 10% Parkinson's disease (this study) Hypothalamic Dopaminergic Neurons 7.11e-4 0.0264 0.48927 0.7780954838709677 0.2638846295514853 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Oxytocin / Vasopressin Expressing Neurons -4.6460600071e-9 2.08023045113e-9 0.9872398719328034 0.9999999952766544 0.26367861841517015 MAGMA Top 10% BMI (Yengo et al., 2018) Oxytocin / Vasopressin Expressing Neurons 0.0232 0.0443 0.30076 0.6273553846153846 0.26367861841517015 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Oxytocin / Vasopressin Expressing Neurons -7.87575924935e-11 8.75659723634e-9 0.5035880729804291 0.8487136733027062 0.25908830069605376 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Oxytocin / Vasopressin Expressing Neurons -0.00658 0.0254 0.60221 0.8430270967741935 0.25908830069605376 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Hypothalamic Dopaminergic Neurons 2.70794849246e-10 4.18729201255e-9 0.47421812036081756 0.8368862346672908 0.25864628740013756 MAGMA Top 10% Anorexia (PGC, 2018) Hypothalamic Dopaminergic Neurons -0.00945 0.0262 0.64081 0.8553866666666666 0.25864628740013756 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Hypothalamic GABAergic Neurons -5.69060062966e-11 6.61307095176e-9 0.5034328879753317 0.8487136733027062 0.2562148309868747 MAGMA Top 10% Bipolar (Stahl et al., 2018) Hypothalamic GABAergic Neurons -0.0078 0.0278 0.61042 0.845196923076923 0.2562148309868747 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Neural Progenitors -1.50961712067e-9 1.36926865052e-9 0.8648775721982914 0.9999999952766544 0.25446595389102866 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Neural Progenitors 0.0105 0.0288 0.35819 0.6846817699115044 0.25446595389102866 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Serotonergic Neuron 3.37398050867e-9 1.14495717173e-8 0.38411848028342255 0.7508560338571879 0.2527702084240694 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Serotonergic Neuron -0.0231 0.026 0.81282 0.9646654945054945 0.2527702084240694 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Hypothalamic Glutamatergic Neurons 2.40441866335e-9 7.90563955944e-9 0.38051073985399 0.7471847255314712 0.2500473877890196 MAGMA Top 10% Bipolar (Stahl et al., 2018) Hypothalamic Glutamatergic Neurons -0.0266 0.0278 0.83088 0.9753808695652174 0.2500473877890196 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Neural Progenitors -2.40880329337e-9 2.36714598557e-9 0.8455655082860263 0.9999999952766544 0.24937020615452188 MAGMA Top 10% Intelligence (Savage et al., 2018) Neural Progenitors 0.0104 0.0326 0.37507 0.7097627947598254 0.24937020615452188 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) astrocytes_ependymal 7.90253049736e-11 5.50620153614e-10 0.442939543009612 0.8073834708023307 0.24567261840014679 MAGMA Top 10% Stroke (Malik et al., 2018) astrocytes_ependymal -0.015 0.0246 0.7283 0.9107232276657061 0.24567261840014679 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) interneurons -1.69868624509e-10 4.15688291592e-10 0.6585996189304948 0.9691180167232253 0.24418653431778276 MAGMA Top 10% Stroke (Malik et al., 2018) interneurons 4.32e-4 0.0252 0.49318 0.7780954838709677 0.24418653431778276 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Radial glia like cells -2.88947072615e-9 2.48747558404e-9 0.8773025681608806 0.9999999952766544 0.24395501484833523 MAGMA Top 10% BMI (Yengo et al., 2018) Radial glia like cells 0.0144 0.0437 0.37063 0.7053399118942731 0.24395501484833523 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Striatal Interneuron -2.3963479847e-9 4.75724691712e-9 0.6927729603855345 0.9780324146619311 0.24344318368179824 MAGMA Top 10% ADHD (Demontis et al., 2017) Striatal Interneuron 0.00201 0.0272 0.47046 0.7698436363636364 0.24344318368179824 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Embryonic GABAergic Neuron -1.12653844429e-9 2.72981065669e-9 0.660079484550627 0.9691180167232253 0.24066477126146396 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Embryonic GABAergic Neuron -7.07e-6 0.0241 0.50012 0.7780954838709677 0.24066477126146396 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) pyramidal CA1 -1.8794557983e-10 5.04955546452e-10 0.6451288566074687 0.9691180167232253 0.24042730429628795 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) pyramidal CA1 -7.68e-4 0.0249 0.51227 0.783269052631579 0.24042730429628795 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Hypothalamic Dopaminergic Neurons 1.8873996774e-9 7.03913039303e-9 0.394299755932093 0.7537057281533813 0.24031967469622423 MAGMA Top 10% Bipolar (Stahl et al., 2018) Hypothalamic Dopaminergic Neurons -0.0275 0.0278 0.83856 0.9764364420485175 0.24031967469622423 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Dopaminergic Adult -6.56309302929e-10 5.23985595635e-10 0.8948121626832662 0.9999999952766544 0.23640157783714985 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Dopaminergic Adult 0.00779 0.0247 0.37624 0.7097627947598254 0.23640157783714985 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Oligodendrocytes -1.02385616772e-9 1.30863773213e-9 0.7830052960259768 0.9999999952766544 0.23415774611463844 MAGMA Top 10% Educational attainment (Lee et al., 2018) Oligodendrocytes 0.00645 0.039 0.43443 0.7542477108433735 0.23415774611463844 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Oligodendrocyte Precursor -1.34429391764e-9 1.05423586557e-9 0.8988694140224875 0.9999999952766544 0.22926255242657886 MAGMA Top 10% Educational attainment (Lee et al., 2018) Oligodendrocyte Precursor 0.0114 0.0397 0.38706 0.7121014468085106 0.22926255242657886 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Oxytocin / Vasopressin Expressing Neurons -2.53427096959e-11 4.69532385668e-10 0.5215222036227667 0.8599144731489894 0.22921930722541353 MAGMA Top 10% Stroke (Malik et al., 2018) Oxytocin / Vasopressin Expressing Neurons -0.0109 0.0251 0.66725 0.8682289156626506 0.22921930722541353 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Neural Progenitors -4.64891261653e-9 4.47367327017e-9 0.8506374491182338 0.9999999952766544 0.22628691588400054 MAGMA Top 10% Anorexia (PGC, 2018) Neural Progenitors 0.00556 0.0258 0.41465 0.7371555555555556 0.22628691588400054 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Hypothalamic Glutamatergic Neurons -4.72752108067e-10 5.0857265361e-10 0.8237022137032683 0.9999999952766544 0.22300008290444168 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Hypothalamic Glutamatergic Neurons 0.00393 0.0239 0.43474 0.7542477108433735 0.22300008290444168 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) pyramidal CA1 -4.18532169876e-10 1.62761467106e-9 0.6014663890676655 0.9421522819478171 0.2224726342057757 MAGMA Top 10% Migraine (Gormley et al., 2016) pyramidal CA1 -0.00637 0.026 0.59682 0.8430270967741935 0.2224726342057757 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Hypothalamic Dopaminergic Neurons -1.4280880312e-9 2.99519269928e-9 0.6832453675620996 0.9691180167232253 0.2210536099466076 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Hypothalamic Dopaminergic Neurons -0.00178 0.0246 0.52883 0.7877743448275862 0.2210536099466076 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) microglia -3.86215851462e-9 7.02399865729e-9 0.7087894971008922 0.9851143350778998 0.22093072996117324 MAGMA Top 10% Bipolar (Stahl et al., 2018) microglia -6.96e-4 0.0276 0.51006 0.783269052631579 0.22093072996117324 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Oligodendrocyte Precursor -1.30388402333e-9 2.31026068602e-9 0.7137550387165057 0.985118775480928 0.21743144732304176 MAGMA Top 10% BMI (Yengo et al., 2018) Oligodendrocyte Precursor -0.00162 0.0439 0.51474 0.783269052631579 0.21743144732304176 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Radial glia like cells -3.39408428072e-11 6.75525356692e-10 0.520035876208195 0.8599144731489894 0.21673374738844747 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Radial glia like cells -0.0127 0.0232 0.70876 0.9005421176470587 0.21673374738844747 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Serotonergic Neuron -3.80897152606e-9 6.10495166876e-9 0.7336583281955164 0.999498178659075 0.2131743971458977 MAGMA Top 10% ADHD (Demontis et al., 2017) Serotonergic Neuron -7.24e-4 0.027 0.51069 0.783269052631579 0.2131743971458977 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Radial glia like cells -1.04133149465e-9 8.14685437014e-10 0.899410665037308 0.9999999952766544 0.21051918297145286 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Radial glia like cells 0.00543 0.0275 0.4217 0.7435689795918368 0.21051918297145286 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Radial glia like cells -1.99533968998e-9 4.56782003753e-9 0.6688810016553879 0.9691180167232253 0.20433863514762657 MAGMA Top 10% Anorexia (PGC, 2018) Radial glia like cells -0.00542 0.0257 0.58341 0.8317924752475246 0.20433863514762657 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) endothelial-mural -5.30903935944e-9 1.16982630299e-8 0.675024917571887 0.9691180167232253 0.203940818038853 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) endothelial-mural -0.00492 0.0246 0.57916 0.828467284768212 0.203940818038853 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Oligodendrocytes -2.3080205308e-9 1.34894822061e-9 0.9564573993881114 0.9999999952766544 0.20330173896674608 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Oligodendrocytes 0.00655 0.0287 0.40995 0.734848132780083 0.20330173896674608 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Oligodendrocyte Precursor -3.15751364672e-9 2.82342485585e-9 0.8682864259625251 0.9999999952766544 0.20120035929432978 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Oligodendrocyte Precursor 0.00272 0.0246 0.45597 0.7630510344827586 0.20120035929432978 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Embryonic midbrain nucleus neurons 1.58560958351e-11 3.28437661503e-9 0.49807402036970805 0.8471180188965114 0.20079288288878822 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Embryonic midbrain nucleus neurons -0.0201 0.0242 0.79638 0.9503761325966851 0.20079288288878822 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Embryonic midbrain nucleus neurons 7.13112670962e-11 2.73591497798e-9 0.4896027987733972 0.8426629843430581 0.1992249915390538 MAGMA Top 10% Age at menarche (Perry et al., 2014) Embryonic midbrain nucleus neurons -0.0259 0.0288 0.81603 0.9658218082191782 0.1992249915390538 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Oxytocin / Vasopressin Expressing Neurons 4.68977462192e-10 2.8604980399e-9 0.43488541659539703 0.8028974563047522 0.19848951462194067 MAGMA Top 10% Age at menarche (Perry et al., 2014) Oxytocin / Vasopressin Expressing Neurons -0.0413 0.0291 0.92182 0.99997 0.19848951462194067 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Oligodendrocytes -2.24518912901e-8 9.66491265556e-9 0.9899112552524353 0.9999999952766544 0.19646767366419646 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Oligodendrocytes 0.00576 0.025 0.40876 0.734848132780083 0.19646767366419646 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Hypothalamic Dopaminergic Neurons -2.38654694689e-9 5.94827274392e-9 0.6558697430179017 0.9691180167232253 0.1961883400093526 MAGMA Top 10% Autism (Grove et al., 2017) Hypothalamic Dopaminergic Neurons -0.00766 0.0256 0.61774 0.8467745110410094 0.1961883400093526 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) pyramidal SS -1.68129783976e-10 4.17546494499e-10 0.6564012696040088 0.9691180167232253 0.1949044638823048 MAGMA Top 10% Stroke (Malik et al., 2018) pyramidal SS -0.00779 0.0253 0.6209 0.8467745110410094 0.1949044638823048 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Hypothalamic Glutamatergic Neurons -1.87467753458e-9 2.05817206863e-9 0.8188117058468103 0.9999999952766544 0.19365821828290136 MAGMA Top 10% Migraine (Gormley et al., 2016) Hypothalamic Glutamatergic Neurons -3.88e-5 0.0255 0.50061 0.7780954838709677 0.19365821828290136 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Oxytocin / Vasopressin Expressing Neurons -2.02215632808e-9 2.17856946837e-9 0.8233490525696916 0.9999999952766544 0.19208985678556736 MAGMA Top 10% Intelligence (Savage et al., 2018) Oxytocin / Vasopressin Expressing Neurons -1.18e-4 0.0321 0.50146 0.7780954838709677 0.19208985678556736 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Oligodendrocytes -3.60312616284e-9 4.39351187502e-9 0.7939209077895959 0.9999999952766544 0.18916899200294346 MAGMA Top 10% Anorexia (PGC, 2018) Oligodendrocytes -0.00177 0.0261 0.52709 0.7877743448275862 0.18916899200294346 LDSC Top 10% (Z P) Anorexia (PGC, 2018) microglia -2.19108864396e-9 5.09723559941e-9 0.6663506121080365 0.9691180167232253 0.18453672959934636 MAGMA Top 10% Anorexia (PGC, 2018) microglia -0.00948 0.0261 0.64154 0.8553866666666666 0.18453672959934636 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Hypothalamic Glutamatergic Neurons -1.24365002893e-9 4.17489394749e-9 0.6171056052519939 0.950860454016859 0.18410297535166192 MAGMA Top 10% Anorexia (PGC, 2018) Hypothalamic Glutamatergic Neurons -0.0135 0.0266 0.69412 0.8951039999999999 0.18410297535166192 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Hypothalamic GABAergic Neurons -2.47069154699e-10 4.48796402168e-10 0.7090169068444989 0.9851143350778998 0.18400947653426175 MAGMA Top 10% Stroke (Malik et al., 2018) Hypothalamic GABAergic Neurons -0.00671 0.0253 0.6044 0.8430270967741935 0.18400947653426175 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) microglia 2.12888022077e-10 1.91108567137e-9 0.45565101601235636 0.8201718288222415 0.18275203328712908 MAGMA Top 10% Migraine (Gormley et al., 2016) microglia -0.0409 0.0254 0.94594 0.99997 0.18275203328712908 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Vascular Leptomeningeal Cells -1.2315546309e-9 2.69492798474e-9 0.6761608155392422 0.9691180167232253 0.18218719395412492 MAGMA Top 10% Age at menarche (Perry et al., 2014) Vascular Leptomeningeal Cells -0.0103 0.0289 0.63911 0.8553866666666666 0.18218719395412492 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) astrocytes_ependymal -1.87742686421e-10 2.31024653272e-9 0.5323844824648685 0.8674595502773738 0.1803700050494328 MAGMA Top 10% Migraine (Gormley et al., 2016) astrocytes_ependymal -0.0231 0.0254 0.81853 0.9661337704918033 0.1803700050494328 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) microglia -1.36726218862e-8 1.08100507011e-8 0.8970296412339898 0.9999999952766544 0.17631593870346146 MAGMA Top 10% Intracranial volume (Adams et al., 2016) microglia 3.26e-4 0.0258 0.49495 0.7780954838709677 0.17631593870346146 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Neural Progenitors -3.55061538082e-9 2.34524537267e-9 0.9349824237447875 0.9999999952766544 0.17450760040721172 MAGMA Top 10% BMI (Yengo et al., 2018) Neural Progenitors 0.00234 0.0441 0.47883 0.7780954838709677 0.17450760040721172 LDSC Top 10% (Z P) Parkinson's disease (this study) Medium Spiny Neuron -2.51287080679e-10 4.54642162433e-10 0.7097703617338724 0.9851143350778998 0.17128662682818324 MAGMA Top 10% Parkinson's disease (this study) Medium Spiny Neuron -0.00989 0.0276 0.64019 0.8553866666666666 0.17128662682818324 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Neural Progenitors -8.70656859588e-9 3.0637274254e-9 0.9977571749483187 0.9999999952766544 0.17116235183081907 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Neural Progenitors 0.0027 0.0243 0.45567 0.7630510344827586 0.17116235183081907 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Embryonic Dopaminergic Neuron -2.88234479995e-10 4.52230618639e-10 0.738055368037604 0.999498178659075 0.16833539590250954 MAGMA Top 10% Stroke (Malik et al., 2018) Embryonic Dopaminergic Neuron -0.00794 0.0251 0.62408 0.8478067924528301 0.16833539590250954 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Embryonic Dopaminergic Neuron -5.16192863919e-9 7.12014973672e-9 0.7657662336366591 0.9999999952766544 0.1673723155505359 MAGMA Top 10% Bipolar (Stahl et al., 2018) Embryonic Dopaminergic Neuron -0.00721 0.0273 0.60417 0.8430270967741935 0.1673723155505359 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Vascular Leptomeningeal Cells -6.452064598e-10 6.76009862584e-10 0.8300678723603323 0.9999999952766544 0.16398127727091064 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Vascular Leptomeningeal Cells -0.00399 0.024 0.56614 0.8207130201342281 0.16398127727091064 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) endothelial-mural -5.41924962248e-11 7.63648728215e-10 0.5282872799852203 0.8644700945212697 0.16362363390629595 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) endothelial-mural -0.0292 0.0237 0.89101 0.9990279792746114 0.16362363390629595 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Oxytocin / Vasopressin Expressing Neurons -1.2914894909e-9 4.44167535092e-9 0.6143849680820102 0.950860454016859 0.16096640861390316 MAGMA Top 10% Anorexia (PGC, 2018) Oxytocin / Vasopressin Expressing Neurons -0.02 0.0264 0.77558 0.9332884679665739 0.16096640861390316 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Oxytocin / Vasopressin Expressing Neurons -3.48402923838e-10 7.37498042524e-9 0.5188395042683895 0.8599144731489894 0.15987792643438464 MAGMA Top 10% Bipolar (Stahl et al., 2018) Oxytocin / Vasopressin Expressing Neurons -0.0399 0.028 0.92302 0.99997 0.15987792643438464 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Vascular Leptomeningeal Cells -1.30127228907e-9 3.70238527048e-9 0.6373815996422232 0.9661363194576857 0.15898500765516754 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Vascular Leptomeningeal Cells -0.0169 0.0245 0.75445 0.9243943342776204 0.15898500765516754 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) interneurons -3.56206946863e-9 9.12418446248e-9 0.6518791139896314 0.9691180167232253 0.15384234992770984 MAGMA Top 10% Intracranial volume (Adams et al., 2016) interneurons -0.0181 0.0261 0.75535 0.9243943342776204 0.15384234992770984 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Embryonic GABAergic Neuron -2.86395666551e-9 2.37315614118e-9 0.8862479955919821 0.9999999952766544 0.15309993116102547 MAGMA Top 10% Age at menarche (Perry et al., 2014) Embryonic GABAergic Neuron -0.00411 0.0284 0.5575 0.8141818181818181 0.15309993116102547 LDSC Top 10% (Z P) Parkinson's disease (this study) microglia -5.37858601205e-10 5.66879000704e-10 0.828640536437264 0.9999999952766544 0.15298620758762477 MAGMA Top 10% Parkinson's disease (this study) microglia -0.00648 0.0265 0.59657 0.8430270967741935 0.15298620758762477 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Neural Progenitors -1.31721253954e-8 5.95621831707e-9 0.9864990855201563 0.9999999952766544 0.1417869161486923 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Neural Progenitors -0.00234 0.0338 0.52763 0.7877743448275862 0.1417869161486923 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Radial glia like cells -2.49775928517e-9 1.38787311077e-9 0.9640462198241401 0.9999999952766544 0.1415813473370276 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Radial glia like cells -0.00294 0.029 0.54043 0.8010197260273971 0.1415813473370276 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) Embryonic GABAergic Neuron -1.61243383737e-9 8.95060979424e-9 0.5714817827793599 0.9076475373554539 0.13694467665681703 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) Embryonic GABAergic Neuron -0.0371 0.025 0.93134 0.99997 0.13694467665681703 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Neuroblasts -1.66661977041e-9 1.83494148081e-9 0.8181318418441725 0.9999999952766544 0.13529537878915365 MAGMA Top 10% Migraine (Gormley et al., 2016) Neuroblasts -0.0102 0.0254 0.65552 0.8660080733944955 0.13529537878915365 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Oligodendrocyte Precursor -1.57433770575e-9 6.02772657559e-9 0.6030241781450937 0.9421522819478171 0.13449203261588258 MAGMA Top 10% Bipolar (Stahl et al., 2018) Oligodendrocyte Precursor -0.0337 0.0271 0.89265 0.9990279792746114 0.13449203261588258 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Oligodendrocytes -2.77276286163e-9 6.7165091786e-9 0.6601336719408305 0.9691180167232253 0.13294107771465988 MAGMA Top 10% Bipolar (Stahl et al., 2018) Oligodendrocytes -0.025 0.0271 0.82126999999999994 0.9667265395095368 0.13294107771465988 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Oligodendrocyte Precursor -4.9996460038e-9 2.04274425716e-9 0.9928077313317194 0.9999999952766544 0.12940528349961247 MAGMA Top 10% Intelligence (Savage et al., 2018) Oligodendrocyte Precursor -0.00465 0.0336 0.55504 0.8141818181818181 0.12940528349961247 LDSC Top 10% (Z P) Alzheimer's disease (Jansen et al., 2019) Serotonergic Neuron -1.81739205923e-10 5.96761606777e-10 0.6196426485372676 0.950860454016859 0.12754281117118713 MAGMA Top 10% Alzheimer's disease (Jansen et al., 2019) Serotonergic Neuron -0.0306 0.0242 0.89696 0.99997 0.12754281117118713 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Oligodendrocytes -2.30247798569e-9 2.59141644779e-9 0.8128645359893314 0.9999999952766544 0.1234274919645438 MAGMA Top 10% BMI (Yengo et al., 2018) Oligodendrocytes -0.023 0.0446 0.69683 0.8959064688427301 0.1234274919645438 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Embryonic midbrain nucleus neurons -2.15075907804e-9 1.79800155267e-9 0.8841896134740181 0.9999999952766544 0.12145646657483052 MAGMA Top 10% Migraine (Gormley et al., 2016) Embryonic midbrain nucleus neurons -0.00949 0.0253 0.64646 0.8574669938650307 0.12145646657483052 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Dopaminergic Adult -2.92012487476e-9 3.95691864502e-9 0.7697365491317549 0.9999999952766544 0.11354410543485016 MAGMA Top 10% Anorexia (PGC, 2018) Dopaminergic Adult -0.0197 0.0266 0.77014 0.9332884679665739 0.11354410543485016 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Oxytocin / Vasopressin Expressing Neurons -4.61465502957e-9 5.31692898907e-9 0.8072802156571399 0.9999999952766544 0.1127158020868011 MAGMA Top 10% Autism (Grove et al., 2017) Oxytocin / Vasopressin Expressing Neurons -0.0164 0.0259 0.73713 0.9150579310344827 0.1127158020868011 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Dopaminergic Adult -2.39318636598e-10 4.59357101094e-10 0.6988117515352122 0.98334422365867 0.1126485330385446 MAGMA Top 10% Stroke (Malik et al., 2018) Dopaminergic Adult -0.0267 0.0255 0.85181 0.9839088770053475 0.1126485330385446 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Dopaminergic Adult -2.31958485991e-9 1.77507195197e-9 0.9043521017126472 0.9999999952766544 0.11067851897748626 MAGMA Top 10% Migraine (Gormley et al., 2016) Dopaminergic Adult -0.0109 0.0257 0.66421 0.8682289156626506 0.11067851897748626 LDSC Top 10% (Z P) Hippocampal volume (Hibar et al., 2017) astrocytes_ependymal -1.21935196185e-8 1.01140522094e-8 0.8860144689121845 0.9999999952766544 0.09841404161923174 MAGMA Top 10% Hippocampal volume (Hibar et al., 2017) astrocytes_ependymal -0.0144 0.025 0.71735 0.9034845481049564 0.09841404161923174 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) microglia -8.93315800392e-10 9.70237355999e-10 0.8214013779439278 0.9999999952766544 0.09560026466614191 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) microglia -0.0219 0.0278 0.78387 0.9391632132963988 0.09560026466614191 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) microglia -5.15793318506e-9 3.80696150419e-9 0.9122703116299579 0.9999999952766544 0.09391487765553028 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) microglia -0.0137 0.0247 0.71129 0.9011063929618768 0.09391487765553028 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Embryonic Dopaminergic Neuron -1.603405619e-9 1.67332129108e-9 0.8310234338644067 0.9999999952766544 0.09281110064962614 MAGMA Top 10% Migraine (Gormley et al., 2016) Embryonic Dopaminergic Neuron -0.0199 0.0253 0.78481 0.9391632132963988 0.09281110064962614 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) microglia -2.00323312155e-9 3.16023815118e-9 0.7369226365124644 0.999498178659075 0.0885895080692218 MAGMA Top 10% Age at menarche (Perry et al., 2014) microglia -0.0372 0.0287 0.9024 0.99997 0.0885895080692218 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Oligodendrocyte Precursor -1.19462471273e-8 5.47337349832e-9 0.9854677784311995 0.9999999952766544 0.08651915306614177 MAGMA Top 10% ADHD (Demontis et al., 2017) Oligodendrocyte Precursor -0.0126 0.0267 0.68127 0.8811635928143713 0.08651915306614177 LDSC Top 10% (Z P) Stroke (Malik et al., 2018) Oligodendrocytes -9.2887529379e-10 5.36621145307e-10 0.9582714739123661 0.9999999952766544 0.08561749579037937 MAGMA Top 10% Stroke (Malik et al., 2018) Oligodendrocytes -0.0135 0.0253 0.70352 0.8991734911242605 0.08561749579037937 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) pyramidal SS -1.06086436261e-9 1.41477537272e-9 0.7733264205984747 0.9999999952766544 0.08478228998586859 MAGMA Top 10% Migraine (Gormley et al., 2016) pyramidal SS -0.0302 0.0262 0.87513 0.9950892631578948 0.08478228998586859 LDSC Top 10% (Z P) Parkinson's disease (this study) interneurons -3.05499077191e-10 4.15859167917e-10 0.768714973586498 0.9999999952766544 0.08417140939506113 MAGMA Top 10% Parkinson's disease (this study) interneurons -0.0327 0.0275 0.88286 0.9984175916230367 0.08417140939506113 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Dopaminergic Adult -8.53016888423e-9 1.02384921192e-8 0.7976190823654001 0.9999999952766544 0.08321570619481014 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Dopaminergic Adult -0.0276 0.0261 0.85462 0.98452224 0.08321570619481014 LDSC Top 10% (Z P) Anorexia (PGC, 2018) Embryonic Dopaminergic Neuron -8.42630485847e-9 4.07520968862e-9 0.9806658072931415 0.9999999952766544 0.08203507022484378 MAGMA Top 10% Anorexia (PGC, 2018) Embryonic Dopaminergic Neuron -0.0138 0.0265 0.69889 0.8959064688427301 0.08203507022484378 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Neuroblasts -5.7285036844e-9 2.89433683879e-9 0.9761038798184425 0.9999999952766544 0.08071433956501493 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Neuroblasts -0.0132 0.0243 0.70644 0.9002421238938052 0.08071433956501493 LDSC Top 10% (Z P) Parkinson's disease (this study) Radial glia like cells -6.91371291893e-10 4.61133891752e-10 0.9331001903733007 0.9999999952766544 0.07762107204318448 MAGMA Top 10% Parkinson's disease (this study) Radial glia like cells -0.0176 0.0261 0.7496 0.9227938461538463 0.07762107204318448 LDSC Top 10% (Z P) Intracranial volume (Adams et al., 2016) Hypothalamic Glutamatergic Neurons -1.51943906528e-8 8.64933668933e-9 0.9605165158488249 0.9999999952766544 0.0772111214973638 MAGMA Top 10% Intracranial volume (Adams et al., 2016) Hypothalamic Glutamatergic Neurons -0.0159 0.0261 0.72958 0.9107232276657061 0.0772111214973638 LDSC Top 10% (Z P) Migraine (Gormley et al., 2016) Hypothalamic GABAergic Neurons -4.05104638174e-9 1.81633888298e-9 0.9871374345321868 0.9999999952766544 0.07508492796821592 MAGMA Top 10% Migraine (Gormley et al., 2016) Hypothalamic GABAergic Neurons -0.0146 0.0255 0.71689 0.9034845481049564 0.07508492796821592 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Oxytocin / Vasopressin Expressing Neurons -1.28723863156e-9 1.47390811589e-9 0.8087640132868429 0.9999999952766544 0.075008145611920915 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Oxytocin / Vasopressin Expressing Neurons -0.0333 0.0289 0.87531 0.9950892631578948 0.075008145611920915 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Neural Progenitors -6.47787480664e-9 6.95526415795e-9 0.824167055378193 0.9999999952766544 0.07134600499604939 MAGMA Top 10% Bipolar (Stahl et al., 2018) Neural Progenitors -0.0304 0.0266 0.87356 0.9950892631578948 0.07134600499604939 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Vascular Leptomeningeal Cells -1.93645884755e-9 9.43064306162e-10 0.97998158984545 0.9999999952766544 0.0669270118298834 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Vascular Leptomeningeal Cells -0.0185 0.0275 0.74977 0.9227938461538463 0.0669270118298834 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Radial glia like cells -1.00702072137e-8 5.68659733586e-9 0.9617085843095671 0.9999999952766544 0.06436322585855135 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Radial glia like cells -0.0251 0.0335 0.77309 0.9332884679665739 0.06436322585855135 LDSC Top 10% (Z P) Autism (Grove et al., 2017) microglia -7.88021838217e-9 6.29259530501e-9 0.8947697526497839 0.9999999952766544 0.061024592220361634 MAGMA Top 10% Autism (Grove et al., 2017) microglia -0.0257 0.0255 0.8438 0.9798967741935485 0.061024592220361634 LDSC Top 10% (Z P) Amyotrophic lateral sclerosis (Nicolas et al., 2018) Embryonic Dopaminergic Neuron -2.59313926201e-9 2.77348844041e-9 0.8250991209762966 0.9999999952766544 0.056173981706523116 MAGMA Top 10% Amyotrophic lateral sclerosis (Nicolas et al., 2018) Embryonic Dopaminergic Neuron -0.0373 0.0245 0.93572 0.99997 0.056173981706523116 LDSC Top 10% (Z P) Anorexia (PGC, 2018) endothelial-mural -5.91025631289e-9 4.37634273991e-9 0.9115723724902735 0.9999999952766544 0.04952766584836463 MAGMA Top 10% Anorexia (PGC, 2018) endothelial-mural -0.0297 0.026 0.87328 0.9950892631578948 0.04952766584836463 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Vascular Leptomeningeal Cells -1.07181595204e-8 6.8360331562e-9 0.9415467932771208 0.9999999952766544 0.048346592005453895 MAGMA Top 10% ADHD (Demontis et al., 2017) Vascular Leptomeningeal Cells -0.0274 0.0264 0.85009 0.9839088770053475 0.048346592005453895 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) astrocytes_ependymal -9.08435311284e-9 1.82235736223e-9 0.999999690104459 0.9999999952766544 0.04803475806716159 MAGMA Top 10% BMI (Yengo et al., 2018) astrocytes_ependymal -0.0374 0.0442 0.80155 0.9539107438016529 0.04803475806716159 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Radial glia like cells -1.69695969763e-9 1.31334228853e-9 0.901837440473246 0.9999999952766544 0.04796300651064782 MAGMA Top 10% Educational attainment (Lee et al., 2018) Radial glia like cells -0.048 0.0393 0.88909 0.9990279792746114 0.04796300651064782 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Oligodendrocytes -6.7836695755e-9 5.81292861971e-9 0.8783941856749481 0.9999999952766544 0.04559677465535711 MAGMA Top 10% Autism (Grove et al., 2017) Oligodendrocytes -0.0367 0.0258 0.92282 0.99997 0.04559677465535711 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) endothelial-mural -5.05434198477e-9 2.49235051264e-9 0.9787169099377915 0.9999999952766544 0.04311164374468835 MAGMA Top 10% Age at menarche (Perry et al., 2014) endothelial-mural -0.0279 0.0283 0.83776 0.9764364420485175 0.04311164374468835 LDSC Top 10% (Z P) Autism (Grove et al., 2017) Vascular Leptomeningeal Cells -6.45344182681e-9 6.27769657574e-9 0.84802395270558 0.9999999952766544 0.04304004158964548 MAGMA Top 10% Autism (Grove et al., 2017) Vascular Leptomeningeal Cells -0.0469 0.0255 0.96719 0.99997 0.04304004158964548 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) astrocytes_ependymal -1.01379546212e-8 6.98462770442e-9 0.9266750277420908 0.9999999952766544 0.03897393098692672 MAGMA Top 10% Bipolar (Stahl et al., 2018) astrocytes_ependymal -0.0354 0.0274 0.90183 0.99997 0.03897393098692672 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) endothelial-mural -2.74490446721e-8 6.87616127842e-9 0.9999672289322713 0.9999999952766544 0.0388130856428882 MAGMA Top 10% Bipolar (Stahl et al., 2018) endothelial-mural -0.0266 0.0271 0.83635 0.9764364420485175 0.0388130856428882 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Hypothalamic Dopaminergic Neurons -6.12030189554e-9 5.22421288783e-9 0.8793063190602034 0.9999999952766544 0.03819441400217184 MAGMA Top 10% ADHD (Demontis et al., 2017) Hypothalamic Dopaminergic Neurons -0.0442 0.0263 0.95383 0.99997 0.03819441400217184 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Oxytocin / Vasopressin Expressing Neurons -9.34331803954e-9 6.50128847996e-9 0.9246621216263419 0.9999999952766544 0.037497315326727565 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Oxytocin / Vasopressin Expressing Neurons -0.0457 0.0341 0.90996 0.99997 0.037497315326727565 LDSC Top 10% (Z P) Autism (Grove et al., 2017) endothelial-mural -8.44937977289e-9 6.19319196935e-9 0.9137636194509623 0.9999999952766544 0.03193611078171845 MAGMA Top 10% Autism (Grove et al., 2017) endothelial-mural -0.0397 0.0249 0.9447 0.99997 0.03193611078171845 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) Oligodendrocytes -7.87450708417e-9 5.05142733638e-9 0.9404861556941688 0.9999999952766544 0.031014867580158735 MAGMA Top 10% ADHD (Demontis et al., 2017) Oligodendrocytes -0.0372 0.0263 0.92176 0.99997 0.031014867580158735 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) Oligodendrocytes -1.75637347156e-9 7.25070090348e-10 0.9922897529416467 0.9999999952766544 0.029968116373233607 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) Oligodendrocytes -0.0325 0.0279 0.87786 0.9953688188976377 0.029968116373233607 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) astrocytes_ependymal -9.3149495892e-9 6.23244934424e-9 0.9324891171630948 0.9999999952766544 0.028300243790740198 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) astrocytes_ependymal -0.0534 0.0341 0.94136 0.99997 0.028300243790740198 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Radial glia like cells -1.61035806677e-8 6.81195556597e-9 0.9909610153214332 0.9999999952766544 0.028205842373646366 MAGMA Top 10% Bipolar (Stahl et al., 2018) Radial glia like cells -0.0326 0.027 0.8862 0.9990279792746114 0.028205842373646366 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) microglia -4.60671973368e-9 3.29630348543e-9 0.9188745479891844 0.9999999952766544 0.027952227745427112 MAGMA Top 10% BMI (Yengo et al., 2018) microglia -0.0753 0.0439 0.95684 0.99997 0.027952227745427112 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Oligodendrocytes -7.49892068329e-9 2.3678899348e-9 0.9992296895370453 0.9999999952766544 0.02100008913409587 MAGMA Top 10% Age at menarche (Perry et al., 2014) Oligodendrocytes -0.0389 0.0292 0.90852 0.99997 0.02100008913409587 LDSC Top 10% (Z P) Bipolar (Stahl et al., 2018) Vascular Leptomeningeal Cells -3.0079403233e-8 6.27979422094e-9 0.9999991655565044 0.9999999952766544 0.019477197462883795 MAGMA Top 10% Bipolar (Stahl et al., 2018) Vascular Leptomeningeal Cells -0.0378 0.0277 0.91421 0.99997 0.019477197462883795 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) astrocytes_ependymal -2.14946806909e-9 1.2849895602e-9 0.9528118757509003 0.9999999952766544 0.018933714371389583 MAGMA Top 10% Educational attainment (Lee et al., 2018) astrocytes_ependymal -0.0709 0.04 0.96189 0.99997 0.018933714371389583 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) astrocytes_ependymal -4.52893214459e-9 2.19238685117e-9 0.9805741483228413 0.9999999952766544 0.016468060086578466 MAGMA Top 10% Intelligence (Savage et al., 2018) astrocytes_ependymal -0.0529 0.033 0.94533 0.99997 0.016468060086578466 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) Vascular Leptomeningeal Cells -3.31691333188e-9 1.36561817203e-9 0.9924270851001844 0.9999999952766544 0.015086768984791322 MAGMA Top 10% Neuroticism (Nagel et al., 2018) Vascular Leptomeningeal Cells -0.0453 0.0291 0.94 0.99997 0.015086768984791322 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Radial glia like cells -5.30918777011e-9 2.58414065827e-9 0.980037662551479 0.9999999952766544 0.01316158561970207 MAGMA Top 10% Intelligence (Savage et al., 2018) Radial glia like cells -0.0572 0.0326 0.96036 0.99997 0.01316158561970207 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) astrocytes_ependymal -5.42627801336e-9 1.30084541133e-9 0.9999848598038997 0.9999999952766544 0.012897170230739446 MAGMA Top 10% Neuroticism (Nagel et al., 2018) astrocytes_ependymal -0.0448 0.0285 0.94235 0.99997 0.012897170230739446 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) astrocytes_ependymal -1.76893098701e-8 5.25044032799e-9 0.9996229430681494 0.9999999952766544 0.012639605045137111 MAGMA Top 10% ADHD (Demontis et al., 2017) astrocytes_ependymal -0.0417 0.0263 0.94381 0.99997 0.012639605045137111 LDSC Top 10% (Z P) ADHD (Demontis et al., 2017) endothelial-mural -8.74231793924e-9 5.16276853787e-9 0.954804532190292 0.9999999952766544 0.011207620609079639 MAGMA Top 10% ADHD (Demontis et al., 2017) endothelial-mural -0.0656 0.0257 0.99465 0.99997 0.011207620609079639 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) endothelial-mural -2.16247660645e-8 5.65951158551e-9 0.999933533330245 0.9999999952766544 0.008508173645036275 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) endothelial-mural -0.0598 0.0338 0.96164 0.99997 0.008508173645036275 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) microglia -5.77349314837e-9 2.34798793083e-9 0.9930320402953642 0.9999999952766544 0.00815265084182671 MAGMA Top 10% Intelligence (Savage et al., 2018) microglia -0.0607 0.0323 0.96991 0.99997 0.00815265084182671 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) endothelial-mural -2.66931345565e-9 7.57390508838e-10 0.9997877429109656 0.9999999952766544 0.006834912288686531 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) endothelial-mural -0.0511 0.0273 0.96922 0.99997 0.006834912288686531 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) Radial glia like cells -5.29741068994e-9 2.45439255791e-9 0.9845492499460959 0.9999999952766544 0.0054277312354771515 MAGMA Top 10% Age at menarche (Perry et al., 2014) Radial glia like cells -0.0669 0.0285 0.99062 0.99997 0.0054277312354771515 LDSC Top 10% (Z P) Age at menarche (Perry et al., 2014) astrocytes_ependymal -7.02751302763e-9 2.34886283797e-9 0.9986136686056432 0.9999999952766544 0.004635036647869688 MAGMA Top 10% Age at menarche (Perry et al., 2014) astrocytes_ependymal -0.0598 0.029 0.98024 0.99997 0.004635036647869688 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) microglia -1.7459982963e-8 6.55202309062e-9 0.9961485592949793 0.9999999952766544 0.0041771547779875145 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) microglia -0.0734 0.0339 0.98474 0.99997 0.0041771547779875145 LDSC Top 10% (Z P) Major depressive disorder (Wray et al., 2018) astrocytes_ependymal -2.13113230316e-9 8.80613906583e-10 0.9922408768699876 0.9999999952766544 0.003948434085471933 MAGMA Top 10% Major depressive disorder (Wray et al., 2018) astrocytes_ependymal -0.0637 0.0275 0.98966 0.99997 0.003948434085471933 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) microglia -2.76343723967e-9 1.23516228466e-9 0.9873668593566922 0.9999999952766544 0.003114965697380878 MAGMA Top 10% Educational attainment (Lee et al., 2018) microglia -0.115 0.039 0.99837 0.99997 0.003114965697380878 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) Vascular Leptomeningeal Cells -7.57865270208e-9 2.52724903458e-9 0.9986446655694651 0.9999999952766544 0.002896254742798132 MAGMA Top 10% Intelligence (Savage et al., 2018) Vascular Leptomeningeal Cells -0.0744 0.0329 0.98809 0.99997 0.002896254742798132 LDSC Top 10% (Z P) Autism (Grove et al., 2017) astrocytes_ependymal -2.13116324733e-8 5.61817368383e-9 0.999925682232313 0.9999999952766544 0.0014977830566395619 MAGMA Top 10% Autism (Grove et al., 2017) astrocytes_ependymal -0.0625 0.0253 0.9932 0.99997 0.0014977830566395619 LDSC Top 10% (Z P) Schizophrenia (Pardiñas et al., 2018) Vascular Leptomeningeal Cells -1.87884617257e-8 7.00616181963e-9 0.9963376029598543 0.9999999952766544 0.001009647930964034 MAGMA Top 10% Schizophrenia (Pardiñas et al., 2018) Vascular Leptomeningeal Cells -0.105 0.0338 0.99902 0.99997 0.001009647930964034 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) endothelial-mural -3.83158205022e-9 1.25920802705e-9 0.998828257217776 0.9999999952766544 8.416803782058183e-4 MAGMA Top 10% Neuroticism (Nagel et al., 2018) endothelial-mural -0.0821 0.0295 0.9973 0.99997 8.416803782058183e-4 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) Vascular Leptomeningeal Cells -9.73926836824e-9 2.24868777357e-9 0.999992581337802 0.9999999952766544 6.801694423306686e-4 MAGMA Top 10% BMI (Yengo et al., 2018) Vascular Leptomeningeal Cells -0.12 0.0439 0.99688 0.99997 6.801694423306686e-4 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) Vascular Leptomeningeal Cells -4.43988669448e-9 1.29769328874e-9 0.9996884655441071 0.9999999952766544 5.54614800856589e-4 MAGMA Top 10% Educational attainment (Lee et al., 2018) Vascular Leptomeningeal Cells -0.114 0.0402 0.99776 0.99997 5.54614800856589e-4 LDSC Top 10% (Z P) Neuroticism (Nagel et al., 2018) microglia -3.71753769471e-9 1.25043410437e-9 0.9985254666109973 0.9999999952766544 3.269416704297031e-4 MAGMA Top 10% Neuroticism (Nagel et al., 2018) microglia -0.117 0.0291 0.99997 0.99997 3.269416704297031e-4 LDSC Top 10% (Z P) BMI (Yengo et al., 2018) endothelial-mural -1.08746470399e-8 2.12978385946e-9 0.9999998354631648 0.9999999952766544 3.194770198362904e-4 MAGMA Top 10% BMI (Yengo et al., 2018) endothelial-mural -0.129 0.0433 0.99853 0.99997 3.194770198362904e-4 LDSC Top 10% (Z P) Intelligence (Savage et al., 2018) endothelial-mural -1.1233711826e-8 2.00867628563e-9 0.9999999888149298 0.9999999952766544 6.298426149032307e-5 MAGMA Top 10% Intelligence (Savage et al., 2018) endothelial-mural -0.113 0.0327 0.99971 0.99997 6.298426149032307e-5 LDSC Top 10% (Z P) Educational attainment (Lee et al., 2018) endothelial-mural -6.56832596539e-9 1.14423282809e-9 0.9999999952766544 0.9999999952766544 8.687089021967388e-6 MAGMA Top 10% Educational attainment (Lee et al., 2018) endothelial-mural -0.154 0.0391 0.99996 0.99997 8.687089021967388e-6