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Mean plasma concentration–time profiles for larotinib and M5 after administration of single and multiple doses of 50, 100, 150, 220, 300, 350 and 400 mg larotinib mesylate (A) Mean plasma concentration–time profile of larotinib after a single dose; (B) mean plasma concentration–time profile of larotinib after multiple doses; (C) mean plasma concentration–time profile of M5 after a single dose; (D) mean plasma concentration–time profile of M5 after multiple doses.
