superpathway of L-serine and glycine biosynthesis I 4 superpathway of branched chain amino acid biosynthesis 14 superpathway of aromatic amino acid biosynthesis 20 superpathway of L-lysine, L-threonine and L-methionine biosynthesis I 19 enterobactin biosynthesis 8 superpathway of L-aspartate and L-asparagine biosynthesis 7 superpathway of 4-aminobutanoate degradation 3 4-aminobutanoate degradation I 3 4-aminobutanoate degradation II 2 ethanolamine utilization 10 superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation 5 superpathway of ornithine degradation 7 adenine and adenosine salvage II 2 adenine and adenosine salvage III 6 adenine and adenosine salvage V 4 glycine betaine biosynthesis I (Gram-negative bacteria) 2 xanthine and xanthosine salvage 3 aminopropylcadaverine biosynthesis 3 L-lysine degradation I 10 superpathway of arginine and polyamine biosynthesis 19 superpathway of polyamine biosynthesis I 7 glutathionylspermidine biosynthesis 1 L-glutamate degradation II 2 Entner-Doudoroff shunt 2 L-glutamine degradation I 11 phosphatidylserine and phosphatidylethanolamine biosynthesis I 2 guanosine nucleotides degradation III 11 L-histidine biosynthesis 8 superpathway of L-asparagine biosynthesis 2 L-asparagine biosynthesis I 1 L-asparagine biosynthesis II 2 L-phenylalanine biosynthesis I 5 L-selenocysteine biosynthesis I (bacteria) 4 uracil degradation III 5 L-aspartate biosynthesis 1 phenylethylamine degradation I 2 L-valine biosynthesis 9 D-glucarate degradation I 5 glycerophosphodiester degradation 6 glycerol and glycerophosphodiester degradation 7 glycerol degradation V 4 thiosulfate disproportionation IV (rhodanese) 4 taurine degradation IV 1 UDP-N-acetyl-D-glucosamine biosynthesis I 4 tRNA processing 9 5-(methoxycarbonylmethoxy)uridine biosynthesis 3 L-proline biosynthesis I (from L-glutamate) 3 queuosine biosynthesis 4 (aminomethyl)phosphonate degradation 12 N6-L-threonylcarbamoyladenosine37-modified tRNA biosynthesis 4 tRNA-uridine 2-thiolation and selenation (bacteria) 12 inosine-5'-phosphate biosynthesis I 5 adenosine ribonucleotides de novo biosynthesis 3 guanosine ribonucleotides de novo biosynthesis 5 demethylmenaquinol-8 biosynthesis I 1 superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation 10 L-arginine degradation II (AST pathway) 5 L-leucine biosynthesis 7 superpathway of L-arginine and L-ornithine degradation 11 L-arginine degradation III (arginine decarboxylase/agmatinase pathway) 3 acetate conversion to acetyl-CoA 1 D-gluconate degradation 2 trehalose biosynthesis I 2 D-malate degradation 1 2-hydroxypenta-2,4-dienoate degradation 4 ubiquinol-8 biosynthesis (prokaryotic) 7 pyruvate decarboxylation to acetyl CoA 3 citrate degradation 3 superpathway of acetate utilization and formation 4 glycogen degradation I 7 pyridoxal 5'-phosphate biosynthesis I 7 dTDP-L-rhamnose biosynthesis 5 thiamine diphosphate biosynthesis I (E. coli) 2 dTDP-N-acetylthomosamine biosynthesis 6 galactose degradation I (Leloir pathway) 5 polymyxin resistance 5 pyrimidine deoxyribonucleotide phosphorylation 4 O-antigen building blocks biosynthesis (E. coli) 10 pyrimidine deoxyribonucleotides dephosphorylation 4 pyridoxal 5'-phosphate salvage I 3 N-end rule pathway I (prokaryotic) 9 pyrimidine deoxyribonucleotides de novo biosynthesis I 13 D-galactarate degradation I 5 UMP biosynthesis I 8 trehalose degradation VI (periplasmic) 1 trehalose degradation I (low osmolarity) 2 trehalose degradation II (cytosolic) 2 colanic acid building blocks biosynthesis 10 prenylated FMNH2 biosynthesis 4 flavin biosynthesis I (bacteria and plants) 8 L-tryptophan degradation II (via pyruvate) 1 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation to 2-hydroxypentadienoate 8 3-dehydroquinate biosynthesis I 4 superpathway of phenylethylamine degradation 12 2,3-dihydroxybenzoate biosynthesis 3 cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate 8 L-lactaldehyde degradation (anaerobic) 1 L-lactaldehyde degradation (aerobic) 2 L-rhamnose degradation I 4 anhydromuropeptides recycling I 13 adenosylcobinamide-GDP salvage from cobinamide I 2 superpathway of adenosylcobalamin salvage from cobinamide I 5 adenosylcobalamin salvage from cobalamin 1 thiazole biosynthesis I (facultative anaerobic bacteria) 9 nitrate reduction IX (dissimilatory) 9 hydrogen to fumarate electron transfer 8 formate to trimethylamine N-oxide electron transfer 8 L-ornithine biosynthesis I 6 NADH to trimethylamine N-oxide electron transfer 15 glycerol-3-phosphate to fumarate electron transfer 7 hydrogen to dimethyl sulfoxide electron transfer 10 hydroxymethylpyrimidine salvage 2 guanosine deoxyribonucleotides de novo biosynthesis II 10 formate to dimethyl sulfoxide electron transfer 9 NADH to dimethyl sulfoxide electron transfer 16 phosphopantothenate biosynthesis I 5 nitrate reduction III (dissimilatory) 12 CMP-3-deoxy-D-manno-octulosonate biosynthesis 5 nitrate reduction X (dissimilatory, periplasmic) 5 hydrogen to trimethylamine N-oxide electron transfer 9 ppGpp biosynthesis 5 nitrate reduction VIIIb (dissimilatory) 4 glycolate and glyoxylate degradation I 7 nitrate reduction VIII (dissimilatory) 19 glycolate and glyoxylate degradation II 4 NADH to fumarate electron transfer 17 formate to nitrite electron transfer 10 2-oxoglutarate decarboxylation to succinyl-CoA 3 tRNA charging 109 D-arabinose degradation I 4 methylglyoxal degradation IV 2 methylglyoxal degradation I 5 methylglyoxal degradation III 6 NAD salvage pathway IV (from nicotinamide riboside) 1 NAD salvage pathway I (PNC VI cycle) 4 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) 9 NAD de novo biosynthesis I (from aspartate) 5 NAD salvage pathway II (PNC IV cycle) 3 NAD phosphorylation and dephosphorylation 3 D-serine degradation 1 autoinducer AI-2 biosynthesis I 2 adenosine nucleotides degradation III 2 adenosine nucleotides degradation II 12 purine deoxyribonucleosides degradation I 2 purine ribonucleosides degradation 5 L-tryptophan biosynthesis 5 pseudouridine degradation 2 beta-D-glucuronide and D-glucuronate degradation 2 superpathway of beta-D-glucuronosides degradation 6 superpathway of purine deoxyribonucleosides degradation 7 L-threonine degradation IV 4 L-threonine degradation II 3 L-methionine biosynthesis I 6 L-threonine degradation I 6 superpathway of L-homoserine and L-methionine biosynthesis 8 L-threonine degradation III (to methylglyoxal) 3 fructoselysine and psicoselysine degradation 3 pyrimidine ribonucleosides degradation 4 pyrimidine deoxyribonucleosides degradation 3 succinate to cytochrome bo oxidase electron transfer 8 NADH to cytochrome bo oxidase electron transfer II 5 proline to cytochrome bo oxidase electron transfer 5 NADH to cytochrome bd oxidase electron transfer I 16 pyruvate to cytochrome bo oxidase electron transfer 5 NADH to cytochrome bd oxidase electron transfer II 4 methylerythritol phosphate pathway I 11 palmitate biosynthesis II (bacteria and plant cytoplasm) 6 menaquinol-8 biosynthesis 1 S-adenosyl-L-methionine biosynthesis 1 tetrahydromonapterin biosynthesis 3 cytidylyl molybdenum cofactor biosynthesis 1 guanylyl molybdenum cofactor biosynthesis 1 citrate lyase activation 6 superpathway of menaquinol-8 biosynthesis I 10 acyl carrier protein metabolism 6 DpiBA Two-Component Signal Transduction System 2 methylphosphonate degradation I 7 Nitrogen Regulation Two-Component System 7 two-component alkanesulfonate monooxygenase 2 BtsSR Two-Component Signal Transduction System 2 assimilatory sulfate reduction I 8 KdpDE Two-Component Signal Transduction System, potassium-dependent 2 superpathway of sulfate assimilation and cysteine biosynthesis 14 Chemotactic Two-Component Signal Transduction 3 beta-alanine biosynthesis III 1 EvgSA Two-Component Signal Transduction System 2 L-homoserine biosynthesis 4 CusSR Two-Component Signal Transduction System 2 alanine racemization 4 PhoRB Two-Component Signal Transduction System, phosphate-dependent 2 ammonia assimilation cycle III 3 ArcAB Two-Component Signal Transduction System, quinone dependent 2 L-glutamine biosynthesis I 1 AtoSC Two-Component Signal Transduction System 2 D-galacturonate degradation I 5 EnvZ/OmrR Two-Component Signal Transduction System 2 L-idonate degradation 3 PhoQP Two-Component Signal Transduction System, magnesium-dependent 2 ketogluconate metabolism 6 HprSR Two-Component Signal Transduction System 2 D-fructuronate degradation 4 RstBA Two-Component Signal Transduction System 2 D-galactonate degradation 3 Aerotactic Two-Component Signal Transduction System 2 N-acetylneuraminate and N-acetylmannosamine degradation I 3 UhpBA Two Component Signal Transduction System 2 NarQ Two-Component Signal Transduction System, nitrate dependent 3 muropeptide degradation 5 S-methyl-5'-thioadenosine degradation IV 1 CpxAR Two-Component Signal Transduction System 2 2-methylcitrate cycle I 6 TorTSR Signal Transduction System, TMAO dependent 2 propanoyl CoA degradation I 1 BaeSR Two-Component Signal Transduction System 2 L-galactonate degradation 1 BarA UvrY Two-Component Signal Transduction System 2 heme b biosynthesis I (aerobic) 4 DcuSR Two-Component Signal Transduction System, C4-dicarboxylate-dependent 2 heme b biosynthesis II (oxygen-independent) 4 ZraSR Two-Component Signal Transduction System 2 superpathway of heme b biosynthesis from uroporphyrinogen-III 5 PyrSR Two-Component Signal Transduction System 2 trans, trans-farnesyl diphosphate biosynthesis 2 Rcs Signal Transduction System 3 di-trans,poly-cis-undecaprenyl phosphate biosynthesis 4 NarX Two-Component Signal Transduction System, nitrate dependent 3 polyisoprenoid biosynthesis (E. coli) 7 CreCB Two-Component Signal Transduction System 2 octaprenyl diphosphate biosynthesis 1 NtrBC Two-Component Signal Transduction System, nitrogen-dependent 2 glycerol-3-phosphate to cytochrome bo oxidase electron transfer 5 BasSR Two-Component Signal Transduction System 2 UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose) 1 GlrKR Two-Component Signal Transduction System 2 UDP-N-acetyl-alpha-D-mannosaminouronate biosynthesis 2 QseBC Two-Component Signal Transduction System, quorum sensing related 2 NADH to cytochrome bo oxidase electron transfer I 17 UDP-alpha-D-glucose biosynthesis I 2 UDP-alpha-D-galactose biosynthesis 1 D-xylose degradation I 2 tetrapyrrole biosynthesis I (from glutamate) 10 fucose degradation 4 L-ascorbate degradation I (bacterial, anaerobic) 4 D-allose degradation 3 L-ascorbate degradation II (bacterial, aerobic) 5 chitobiose degradation 2 ethylene glycol degradation 2 2-deoxy-alpha-D-ribose 1-phosphate degradation 5 superpathway of glycol metabolism and degradation 10 glucose and glucose-1-phosphate degradation 7 pyruvate to cytochrome bd oxidase electron transfer 4 ribose phosphorylation 2 D-lactate to cytochrome bo oxidase electron transfer 5 fructose degradation 1 succinate to cytochrome bd oxidase electron transfer 7 2-O-alpha-mannosyl-D-glycerate degradation 3 L-cysteine biosynthesis I 3 L-lyxose degradation 5 D-gulosides conversion to D-glucosides 3 sulfoquinovose degradation I 5 allantoin degradation to glyoxylate III 4 melibiose degradation 1 allantoin degradation IV (anaerobic) 7 D-mannose degradation 1 L-cysteine biosynthesis VII (from S-sulfo-L-cysteine) 6 allantoin degradation to ureidoglycolate II (ammonia producing) 3 cyanate degradation 2 PRPP biosynthesis 1 molybdenum cofactor biosynthesis 10 chorismate biosynthesis I 10 superpathway of L-alanine biosynthesis 6 chorismate biosynthesis from 3-dehydroquinate 6 L-alanine biosynthesis II 2 2-carboxy-1,4-naphthoquinol biosynthesis 7 L-alanine biosynthesis I 2 L-alanine biosynthesis III 2 proline degradation 1 L-threonine biosynthesis 2 gluconeogenesis I 17 GDP-mannose biosynthesis 4 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 2 glycine cleavage 4 ADP-L-glycero-beta-D-manno-heptose biosynthesis 4 NADH to hydrogen peroxide electron transfer 14 (5Z)-dodecenoate biosynthesis I 6 siroheme biosynthesis 1 ATP biosynthesis 8 cis-vaccenate biosynthesis 7 glycerol-3-phosphate to hydrogen peroxide electron transport 4 superpathway of unsaturated fatty acids biosynthesis (E. coli) 8 pyrimidine deoxyribonucleotides de novo biosynthesis II 9 fatty acid beta-oxidation I 7 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 23 L-cysteine degradation II 6 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) 16 oleate beta-oxidation 9 coenzyme A biosynthesis I (prokaryotic) 3 UTP and CTP de novo biosynthesis 4 superpathway of fatty acid biosynthesis I (E. coli) 11 superpathway of pyrimidine ribonucleotides de novo biosynthesis 12 superpathway of fatty acid biosynthesis initiation (E. coli) 7 D-sorbitol degradation II 1 fatty acid biosynthesis initiation III 3 galactitol degradation 9 fatty acid biosynthesis initiation II 4 superpathway of hexitol degradation (bacteria) 28 fatty acid elongation -- saturated 7 mannitol degradation I 1 lipid IVA biosynthesis (E. coli) 7 superpathway of (Kdo)2-lipid A biosynthesis 16 biotin-carboxyl carrier protein assembly 4 lipid A-core biosynthesis (E. coli K-12) 10 superpathway of lipopolysaccharide biosynthesis 25 (Kdo)2-lipid A biosynthesis I (E. coli) 3 cardiolipin biosynthesis I 6 cardiolipin biosynthesis III 5 superoxide radicals degradation 6 glyoxylate cycle 7 sedoheptulose bisphosphate bypass 2 superpathway of glycolysis and the Entner-Doudoroff pathway 22 superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass 43 L-asparagine degradation I 3 fatty acid biosynthesis initiation (bacteria and plants) 5 cadaverine biosynthesis 2 arginine dependent acid resistance 1 L-glutamate degradation IX (via 4-aminobutanoate) 2 putrescine biosynthesis I 2 putrescine biosynthesis III 1 L-alanine degradation I 5 4-hydroxybenzoate biosynthesis II (bacteria) 1 acetate and ATP formation from acetyl-CoA I 3 mixed acid fermentation 33 conversion of succinate to propanoate 3 preQ0 biosynthesis 4 peptidoglycan biosynthesis I (meso-diaminopimelate containing) 11 spermidine biosynthesis I 2 peptidoglycan maturation (meso-diaminopimelate containing) 13 TCA cycle I (prokaryotic) 21 pentose phosphate pathway (non-oxidative branch) 7 glycerol degradation I 5 superpathway of pyrimidine deoxyribonucleosides degradation 8 acetoacetate degradation (to acetyl CoA) 4 pentose phosphate pathway (oxidative branch) I 3 pentose phosphate pathway 10 lipoate biosynthesis and incorporation I 4 adenosine deoxyribonucleotides de novo biosynthesis II 9 lipoate salvage I 1 curcumin degradation 1 lipoate biosynthesis and incorporation II 3 autoinducer AI-2 degradation 3 CDP-diacylglycerol biosynthesis I 4 CDP-diacylglycerol biosynthesis II 5 aspartate superpathway 25 superpathway of guanosine nucleotides de novo biosynthesis II 13 superpathway of hexuronide and hexuronate degradation 8 superpathway of adenosine nucleotides de novo biosynthesis II 12 superpathway of ubiquinol-8 biosynthesis (prokaryotic) 11 superpathway of purine nucleotides de novo biosynthesis II 24 superpathway of pyridoxal 5'-phosphate biosynthesis and salvage 9 thiamine salvage II 5 superpathway of phospholipid biosynthesis I (bacteria) 14 hydrogen sulfide biosynthesis I 2 superpathway of L-threonine metabolism 20 superpathway of S-adenosyl-L-methionine biosynthesis 9 lactose degradation III 1 superpathway of histidine, purine, and pyrimidine biosynthesis 43 superpathway of D-glucarate and D-galactarate degradation 6 palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) 6 superpathway of fucose and rhamnose degradation 11 phenylacetate degradation I (aerobic) 10 superpathway of chorismate metabolism 56 arsenate detoxification II (glutaredoxin) 5 superpathway of L-threonine biosynthesis 7 putrescine degradation II 4 superpathway of glyoxylate bypass and TCA 23 putrescine degradation I 3 8-amino-7-oxononanoate biosynthesis I 8 superpathway of methylglyoxal degradation 13 S-adenosyl-L-methionine cycle I 5 L-tyrosine biosynthesis I 4 adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I 3 L-isoleucine biosynthesis I (from threonine) 8 5-aminoimidazole ribonucleotide biosynthesis I 5 5-aminoimidazole ribonucleotide biosynthesis II 5 periplasmic disulfide bond reduction 1 superpathway of 5-aminoimidazole ribonucleotide biosynthesis 6 L-serine degradation 4 lipoprotein posttranslational modification 5 L-serine biosynthesis I 3 periplasmic disulfide bond formation 2 glycine biosynthesis I 1 formaldehyde oxidation II (glutathione-dependent) 3 sulfate activation for sulfonation 3 L-glutamate biosynthesis III 1 L-glutamate biosynthesis I 2 glycolysis I (from glucose 6-phosphate) 18 N-acetylglucosamine degradation I 2 glycolysis II (from fructose 6-phosphate) 18 pyrimidine nucleobases salvage II 2 glycogen biosynthesis I (from ADP-D-Glucose) 4 pyrimidine ribonucleosides salvage II 4 salvage pathways of pyrimidine deoxyribonucleotides 4 CMP phosphorylation 3 pyrimidine ribonucleosides salvage III 4 pyrimidine nucleobases salvage I 1 superpathway of pyrimidine nucleobases salvage 5 superpathway of pyrimidine ribonucleosides salvage 11 pyrimidine ribonucleosides salvage I 2 salvage pathways of pyrimidine ribonucleotides 9 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I 4 tetrahydrofolate biosynthesis 4 superpathway of tetrahydrofolate biosynthesis 11 4-aminobenzoate biosynthesis 3 folate polyglutamylation 2 N10-formyl-tetrahydrofolate biosynthesis 12 biotin biosynthesis from 8-amino-7-oxononanoate I 4 biotin biosynthesis I 12 L-arabinose degradation I 3 superpathway of coenzyme A biosynthesis I (bacteria) 9 Kdo transfer to lipid IVA I (E. coli) 1 enterobacterial common antigen biosynthesis 11 thioredoxin pathway 3 glutathione-glutaredoxin redox reactions 5 glutathione biosynthesis 2 L-arginine biosynthesis I (via L-ornithine) 12 ethanol degradation I 4 cyclopropane fatty acid (CFA) biosynthesis 1 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation 12 L-carnitine degradation I 4 L-lysine biosynthesis I 10 guanine and guanosine salvage 5 superpathway of guanine and guanosine salvage 6 guanine and guanosine salvage III 1 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis 2 superpathway of thiamine diphosphate biosynthesis I 13