Table S3. Drug screening and Z score for IR vs. Sen cells,,,,,,,,,, ,Jeko-1-Sen-LD50,Jeko-1-IR-LD50,Jeko-1-Sen-Zscore,Jeko-1-IR-Zscore,,,SP49-Sen-LD50,SP49-IR-LD50,SP49-Sen-Zscore,SP49-IR-Zscore A-1210477(MCL-1),1.98346803,7.906328088,0.599902,1.0999,,A133,6.99E-08,1.35E-06,-0.63761,-0.42363 A-1331852(BCL-XL),0.051680429,0.16333054,-0.50556,-0.58189,,ABT199,4.31E-06,5.11E-08,0.501006,-0.71715 ABT-199,0.080491332,3.59939E+21,-0.52503,-0.66692,,ABT199+A133,5.08E-08,5.23E-08,-0.64274,-0.71689 ABT-263,0.016835419,2.1233E+28,-0.64698,-0.70624,,ABT263,5.74E-08,5.14E-08,-0.64096,-0.71709 ACP-196,0.097775855,0.585710308,0.270621,0.534931,,AUY922,5.61E-08,6.30E-08,-0.64131,-0.71445 Alisertib,,5.269067358,-0.52723,-0.59646,,AZD7762,5.00E-08,5.04E-08,-0.64294,-0.71732 AUY-922,0.133918705,0.054817111,-0.76012,-0.76416,,AZD8055,6.41E-08,8.46E-08,-0.63917,-0.70957 AZD7762,0.018939908,93.85796774,-0.76818,-0.75875,,BENDAMUSTINE,4.32E-06,1.09E-05,0.503581,1.738686 AZD8055,0.014838744,0.019664408,-0.69173,-0.7334,,BTZ,3.04E-09,6.34E-09,-0.65556,-0.72731 BEZ-235,0.011698092,0.001762255,-0.67857,-0.72601,,CFZ,2.92E-09,2.08E-09,-0.65559,-0.72828 Bortezomib,0,0.027329344,-0.77487,-0.7752,,CPA7,4.80E-07,2.75E-06,-0.5275,-0.10507 BS-181,9158.636227,1264.908207,1.706227,1.227425,,CPD23,1.85E-07,3.10E-07,-0.60667,-0.65839 Cal-101,4.043094192,513.118064,1.081087,1.148381,,DINACICLIB,4.45E-09,3.88E-09,-0.65518,-0.72787 Carfilzomib,0.001959737,0.001368108,-0.78287,-0.7817,,DOX,5.00E-08,5.46E-08,-0.64294,-0.71637 "CDK4,6",,0.178870089,0.402775,0.440181,,GSK343,1.00E-05,1.00E-05,2.029986,1.539579 Dinaciclib,0.003620376,0.003470121,-0.78267,-0.77942,,GSK343+THZ531,5.67E-07,8.27E-08,-0.50402,-0.70998 INCB050465(PI3Kd),212196.5246,0.001081401,1.55512,2.044744,,IBRUTINIB,6.47E-08,1.00E-05,-0.63898,1.539579 INCB052793(JAK1),,,3.088564,2.619041,,INCB052793,1.00E-05,1.00E-05,2.029986,1.539579 INCB053914(PIM),0.428158193,0.792429042,0.355734,0.15956,,INCB054329,4.46E-06,1.02E-06,0.541667,-0.49634 INCB054329,0.124532929,0.089122978,-0.6302,-0.70382,,LEN,1.00E-05,1.00E-05,2.029986,1.539579 JQ1,0.304244764,0.172399356,-0.60034,-0.66129,,NVP2,2.74E-08,2.36E-08,-0.64901,-0.72339 Lenalidomide,71.43419401,1.58124E-07,1.385842,1.637804,,OLAPARIB,4.67E-06,6.59E-06,0.598043,0.764952 MK-1775,0,1.63963E-06,-0.75586,-0.75339,,PRT1,1.00E-05,1.00E-05,2.029986,1.539579 MK2206,0.59930756,2.734351031,0.771289,0.713409,,S63845,7.40E-07,2.98E-07,-0.45757,-0.66126 Olaparib(AZD2281),2.599049056,3.244242677,0.986894,0.748918,,THZ1,5.50E-08,4.16E-08,-0.64159,-0.71931 PCI,0.068795352,0.212759066,0.199222,0.552991,,THZ531,4.04E-07,2.40E-08,-0.54797,-0.7233 PIK-75,0.005854952,0.011309429,-0.77683,-0.77308,,TRAMETINIB,4.31E-07,1.00E-05,-0.54072,1.539579 Silvestrol,0.001031789,0.000440483,-0.78306,-0.78151,,TRAMETINIB+S63845,6.18E-08,2.25E-07,-0.63977,-0.67779 THZ1,0.04447854,0.049328654,-0.6481,-0.61253,,VE821,4.51E-06,5.54E-06,0.555828,0.526897 Volasertib,0.04280435,0.01944847,-0.76508,-0.77152,,VOLASERTIB,5.27E-08,5.26E-08,-0.64223,-0.71683