# Electronic Supplementary Material (ESI) for Chemical Science. # This journal is © The Royal Society of Chemistry 2020 ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_hd_wql24 _database_code_depnum_ccdc_archive 'CCDC 1944631' loop_ _audit_author_name _audit_author_address 'Qilin Wang' ;Henan University China ; _audit_update_record ; 2019-08-01 deposited with the CCDC. 2019-12-17 downloaded from the CCDC. ; _chemical_name_systematic ? _chemical_name_common ? _chemical_formula_moiety 'C38 H42 Br N5 O3, 2(C H4 O)' _chemical_formula_sum 'C40 H50 Br N5 O5' _chemical_formula_iupac ? _chemical_formula_weight 760.76 _chemical_melting_point ? _space_group_crystal_system monoclinic _space_group_name_H-M_alt 'P 1 21/c 1' _space_group_name_Hall '-P 2ybc' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y-1/2, z-1/2' _cell_length_a 11.9227(3) _cell_length_b 17.3502(4) _cell_length_c 17.7857(4) _cell_angle_alpha 90 _cell_angle_beta 90.6110(10) _cell_angle_gamma 90 _cell_volume 3678.96(15) _cell_formula_units_Z 4 _cell_measurement_reflns_used 9922 _cell_measurement_theta_min 3.5589 _cell_measurement_theta_max 72.3720 _cell_measurement_temperature 100.(2) _exptl_crystal_description prism _exptl_crystal_colour 'translucent light yellow' _exptl_crystal_size_max 0.200 _exptl_crystal_size_mid 0.100 _exptl_crystal_size_min 0.050 _exptl_crystal_density_diffrn 1.374 _exptl_crystal_density_meas ? _exptl_crystal_density_method 'not measured' _exptl_crystal_F_000 1600 _exptl_absorpt_coefficient_mu 1.937 _exptl_absorpt_correction_type Multi-Scan _exptl_absorpt_process_details ; SADABS-2016/2 - Bruker AXS area detector scaling and absorption correction ; _exptl_absorpt_correction_T_min 0.32 _exptl_absorpt_correction_T_max 0.91 _exptl_special_details ; ; _diffrn_ambient_temperature 100.(2) _diffrn_source 'Ius Diamond' _diffrn_source_type Microfocus _diffrn_radiation_type 'Cu K\a' _diffrn_radiation_wavelength 1.54178 _diffrn_radiation_monochromator 'Helixos MX multilayer Optic' _diffrn_measurement_device_type 'Bruker D8 QUEST PHOTON II' _diffrn_measurement_method ? _diffrn_detector_area_resol_mean 7.3910 _diffrn_reflns_number 36068 _diffrn_reflns_av_R_equivalents 0.0503 _diffrn_reflns_av_unetI/netI 0.0316 _diffrn_reflns_theta_min 3.56 _diffrn_reflns_theta_max 72.36 _diffrn_reflns_theta_full 72.36 _diffrn_measured_fraction_theta_max 0.997 _diffrn_measured_fraction_theta_full 0.997 _diffrn_reflns_limit_h_min -14 _diffrn_reflns_limit_h_max 14 _diffrn_reflns_limit_k_min -21 _diffrn_reflns_limit_k_max 16 _diffrn_reflns_limit_l_min -21 _diffrn_reflns_limit_l_max 21 _refine_special_details ; ; _reflns_number_total 7252 _reflns_number_gt 6204 _reflns_threshold_expression 'I > 2\s(I)' _refine_ls_structure_factor_coef Fsqd _refine_ls_matrix_type full _refine_ls_R_factor_all 0.0897 _refine_ls_R_factor_gt 0.0814 _refine_ls_wR_factor_gt 0.2343 _refine_ls_wR_factor_ref 0.2467 _refine_ls_goodness_of_fit_ref 1.027 _refine_ls_restrained_S_all 1.027 _refine_ls_number_reflns 7252 _refine_ls_number_parameters 468 _refine_ls_number_restraints 0 _refine_ls_number_constraints ? _refine_ls_hydrogen_treatment constr _refine_ls_weighting_scheme calc _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.1618P)^2^+4.8126P] where P=(Fo^2^+2Fc^2^)/3' _atom_sites_solution_hydrogens geom _atom_sites_solution_primary ? _atom_sites_solution_secondary ? _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_diff_density_max 1.901 _refine_diff_density_min -1.272 _refine_ls_extinction_method none _refine_ls_extinction_coef ? loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' Br Br -0.6763 1.2805 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _computing_data_collection 'Bruker Instrument Service vV6.2.9' _computing_cell_refinement 'SAINT V8.38A (Bruker AXS Inc., 2017)' _computing_data_reduction 'SAINT V8.38A (Bruker AXS Inc., 2017)' _computing_structure_solution 'SHELXT 2014/5 (Sheldrick, 2014)' _computing_structure_refinement 'SHELXL-2017/1 (Sheldrick, 2017)' _computing_molecular_graphics 'shelXle (C.B. Huebschle, rev 882)' _computing_publication_material ? loop_ _atom_site_type_symbol _atom_site_label _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_calc_flag _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_refinement_flags_posn _atom_site_occupancy _atom_site_disorder_assembly _atom_site_disorder_group Br Br1 0.05262(4) 0.91737(3) 0.51741(3) 0.0642(2) Uani d . . . 1 . . O O1 0.5143(2) 0.75815(15) 0.10367(15) 0.0411(6) Uani d . . . 1 . . H H25 0.531535 0.804587 0.110485 0.062 Uiso calc U . R 1 . . O O2 0.1960(2) 0.64175(18) 0.19320(15) 0.0471(6) Uani d . . . 1 . . H H26 0.130501 0.648956 0.208597 0.071 Uiso calc U . R 1 . . O O3 0.4582(2) 0.40598(16) 0.36178(16) 0.0449(6) Uani d . . . 1 . . O O4 -0.1760(3) 0.7530(3) 0.1455(2) 0.0753(10) Uani d . . . 1 . . H H44 -0.229159 0.723439 0.156344 0.113 Uiso calc U . R 1 . . N N1 0.3216(2) 0.66081(18) 0.37545(15) 0.0359(6) Uani d . . . 1 . . N N2 0.4910(2) 0.70979(17) 0.31365(16) 0.0344(6) Uani d . . . 1 . . N N3 0.5984(3) 0.51914(19) 0.16670(17) 0.0415(7) Uani d . . . 1 . . N N4 0.5909(3) 0.71019(18) 0.14400(16) 0.0379(6) Uani d . . . 1 . . N N5 0.2534(3) 0.58881(18) 0.24266(17) 0.0380(6) Uani d . . . 1 . . H H42 0.223264 0.548812 0.265186 0.046 Uiso calc U . R 1 . . O O5 -0.0203(3) 0.6738(4) 0.2376(2) 0.1006(19) Uani d . . . 1 . . H H45 -0.064529 0.698225 0.209296 0.151 Uiso calc U . R 1 . . C C1 0.1292(3) 0.8332(2) 0.4750(2) 0.0442(8) Uani d . . . 1 . . C C2 0.2168(3) 0.8013(2) 0.5156(2) 0.0436(8) Uani d . . . 1 . . H H2 0.233095 0.818349 0.565311 0.052 Uiso calc U . R 1 . . C C3 0.2804(3) 0.7443(2) 0.4830(2) 0.0419(8) Uani d . . . 1 . . H H3 0.341758 0.722352 0.5099 0.05 Uiso calc U . R 1 . . C C4 0.2547(3) 0.7186(2) 0.41046(19) 0.0368(7) Uani d . . . 1 . . C C5 0.3770(3) 0.6828(2) 0.30317(18) 0.0344(7) Uani d . . . 1 . . H H12 0.33248 0.72574 0.280059 0.041 Uiso calc U . R 1 . . C C6 0.5700(3) 0.6499(2) 0.3404(2) 0.0376(7) Uani d . . . 1 . . H H4 0.553341 0.637064 0.393328 0.045 Uiso calc U . R 1 . . H H27 0.647487 0.670197 0.338519 0.045 Uiso calc U . R 1 . . C C7 0.5620(3) 0.5767(2) 0.29268(19) 0.0358(7) Uani d . . . 1 . . H H28 0.608 0.535575 0.317459 0.043 Uiso calc U . R 1 . . C C8 0.6086(3) 0.5911(2) 0.2130(2) 0.0383(7) Uani d . . . 1 . . H H15 0.689081 0.606952 0.216693 0.046 Uiso calc U . R 1 . . C C9 0.7078(3) 0.4854(2) 0.1500(2) 0.0472(9) Uani d . . . 1 . . H H17 0.759145 0.526655 0.133263 0.057 Uiso calc U . R 1 . . H H16 0.699064 0.448175 0.10813 0.057 Uiso calc U . R 1 . . C C10 0.7597(3) 0.4445(2) 0.2171(2) 0.0457(8) Uani d . . . 1 . . C C11 0.8757(4) 0.4477(3) 0.2299(3) 0.0567(11) Uani d . . . 1 . . H H21 0.920961 0.480596 0.200263 0.068 Uiso calc U . R 1 . . C C12 0.9250(4) 0.4026(4) 0.2862(3) 0.0686(14) Uani d . . . 1 . . H H20 1.003824 0.404713 0.294271 0.082 Uiso calc U . R 1 . . C C13 0.8605(5) 0.3551(4) 0.3300(3) 0.0669(14) Uani d . . . 1 . . H H1 0.895111 0.323715 0.367392 0.08 Uiso calc U . R 1 . . C C14 0.3306(3) 0.5876(2) 0.40244(19) 0.0378(7) Uani d . . . 1 . . C C15 0.3897(3) 0.5322(2) 0.36442(19) 0.0379(7) Uani d . . . 1 . . C C16 0.4388(3) 0.5491(2) 0.28799(18) 0.0356(7) Uani d . . . 1 . . H H29 0.434939 0.501349 0.256525 0.043 Uiso calc U . R 1 . . C C17 0.4976(3) 0.7779(2) 0.3626(2) 0.0392(7) Uani d . . . 1 . . H H11 0.484808 0.761656 0.415177 0.047 Uiso calc U . R 1 . . H H5 0.437008 0.814128 0.348231 0.047 Uiso calc U . R 1 . . C C18 0.6087(3) 0.8193(2) 0.3587(2) 0.0402(8) Uani d . . . 1 . . C C19 0.6615(3) 0.8442(3) 0.4250(2) 0.0486(9) Uani d . . . 1 . . H H6 0.629995 0.831952 0.472317 0.058 Uiso calc U . R 1 . . C C20 0.7608(4) 0.8872(3) 0.4216(3) 0.0564(11) Uani d . . . 1 . . H H10 0.794981 0.905639 0.466588 0.068 Uiso calc U . R 1 . . C C21 0.8087(3) 0.9028(3) 0.3539(3) 0.0522(10) Uani d . . . 1 . . H H7 0.876626 0.93133 0.351886 0.063 Uiso calc U . R 1 . . C C22 0.7578(4) 0.8769(3) 0.2880(3) 0.0504(9) Uani d . . . 1 . . H H9 0.791785 0.887077 0.240965 0.061 Uiso calc U . R 1 . . C C23 0.6582(3) 0.8365(2) 0.2905(2) 0.0466(8) Uani d . . . 1 . . H H8 0.623174 0.820171 0.244963 0.056 Uiso calc U . R 1 . . C C24 0.3712(3) 0.6132(2) 0.24896(18) 0.0337(7) Uani d . . . 1 . . C C25 0.4193(3) 0.6332(2) 0.17008(18) 0.0345(7) Uani d . . . 1 . . H H24 0.376341 0.677192 0.147585 0.041 Uiso calc U . R 1 . . C C26 0.4149(3) 0.5623(2) 0.1155(2) 0.0412(8) Uani d . . . 1 . . H H14 0.369495 0.520998 0.138608 0.049 Uiso calc U . R 1 . . H H13 0.377268 0.577833 0.068015 0.049 Uiso calc U . R 1 . . C C27 0.5309(3) 0.5306(2) 0.0978(2) 0.0426(8) Uani d . . . 1 . . H H23 0.52291 0.480884 0.07107 0.051 Uiso calc U . R 1 . . H H22 0.570145 0.566983 0.064236 0.051 Uiso calc U . R 1 . . C C28 0.5412(3) 0.6536(2) 0.17528(19) 0.0368(7) Uani d . . . 1 . . C C29 0.7462(4) 0.3528(3) 0.3197(3) 0.0543(10) Uani d . . . 1 . . H H18 0.701108 0.320845 0.3505 0.065 Uiso calc U . R 1 . . C C30 0.6968(3) 0.3983(2) 0.2632(2) 0.0443(8) Uani d . . . 1 . . H H19 0.617666 0.397205 0.25665 0.053 Uiso calc U . R 1 . . C C31 0.4021(3) 0.4557(2) 0.3941(2) 0.0399(8) Uani d . . . 1 . . C C32 0.3452(3) 0.4364(2) 0.4673(2) 0.0447(8) Uani d . . . 1 . . H H31 0.398458 0.4459 0.509436 0.054 Uiso calc U . R 1 . . H H30 0.326046 0.380896 0.467573 0.054 Uiso calc U . R 1 . . C C33 0.2388(3) 0.4832(2) 0.4803(2) 0.0446(8) Uani d . . . 1 . . C C34 0.1478(4) 0.4637(3) 0.4213(2) 0.0532(10) Uani d . . . 1 . . H H32 0.175413 0.475948 0.370983 0.08 Uiso calc U . R 1 . . H H34 0.080231 0.494067 0.431238 0.08 Uiso calc U . R 1 . . H H33 0.129744 0.408681 0.42407 0.08 Uiso calc U . R 1 . . C C35 0.1934(4) 0.4658(3) 0.5585(2) 0.0514(10) Uani d . . . 1 . . H H35 0.172305 0.411345 0.561513 0.077 Uiso calc U . R 1 . . H H37 0.127324 0.49799 0.567739 0.077 Uiso calc U . R 1 . . H H36 0.251295 0.477072 0.596451 0.077 Uiso calc U . R 1 . . C C36 0.2703(3) 0.5688(2) 0.4750(2) 0.0406(8) Uani d . . . 1 . . H H39 0.201281 0.600354 0.478008 0.049 Uiso calc U . R 1 . . H H38 0.319171 0.582567 0.518263 0.049 Uiso calc U . R 1 . . C C37 0.1645(3) 0.7506(2) 0.37098(19) 0.0376(7) Uani d . . . 1 . . H H41 0.146463 0.732815 0.321808 0.045 Uiso calc U . R 1 . . C C38 0.1012(3) 0.8083(2) 0.4034(2) 0.0427(8) Uani d . . . 1 . . H H40 0.039592 0.830449 0.376899 0.051 Uiso calc U . R 1 . . C C40 -0.0758(4) 0.6523(4) 0.3026(3) 0.0710(14) Uani d . . . 1 . . H H47 -0.020898 0.635663 0.340617 0.107 Uiso calc U . R 1 . . H H46 -0.127365 0.609843 0.291187 0.107 Uiso calc U . R 1 . . H H43 -0.118245 0.696385 0.321774 0.107 Uiso calc U . R 1 . . C C41 -0.1423(5) 0.7385(4) 0.0748(4) 0.0752(15) Uani d . . . 1 . . H H50 -0.189244 0.767426 0.039171 0.113 Uiso calc U . R 1 . . H H49 -0.149209 0.683203 0.064469 0.113 Uiso calc U . R 1 . . H H48 -0.063828 0.754236 0.069447 0.113 Uiso calc U . R 1 . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_12 _atom_site_aniso_U_13 _atom_site_aniso_U_23 Br1 0.0549(3) 0.0649(4) 0.0728(4) 0.0082(2) -0.0031(2) -0.0219(2) O1 0.0433(13) 0.0367(12) 0.0429(13) -0.0005(10) -0.0082(10) 0.0037(10) O2 0.0386(13) 0.0612(17) 0.0414(13) 0.0021(12) -0.0076(10) 0.0116(12) O3 0.0469(15) 0.0425(14) 0.0452(14) 0.0031(11) -0.0045(11) 0.0045(11) O4 0.057(2) 0.096(3) 0.073(2) -0.0078(19) -0.0007(17) 0.004(2) N1 0.0342(14) 0.0420(15) 0.0313(13) 0.0017(12) -0.0029(11) 0.0007(11) N2 0.0319(13) 0.0362(14) 0.0351(13) -0.0008(11) -0.0051(10) -0.0010(11) N3 0.0438(16) 0.0438(16) 0.0368(15) 0.0068(13) -0.0015(12) -0.0026(12) N4 0.0379(15) 0.0417(16) 0.0341(14) 0.0005(12) -0.0025(11) -0.0004(12) N5 0.0356(15) 0.0435(16) 0.0348(14) -0.0036(12) -0.0077(11) 0.0058(12) O5 0.0424(17) 0.185(6) 0.075(2) 0.011(2) 0.0018(16) 0.062(3) C1 0.0424(19) 0.0436(19) 0.0467(19) -0.0014(16) 0.0074(15) -0.0076(15) C2 0.0414(18) 0.051(2) 0.0380(17) -0.0057(16) -0.0014(14) -0.0058(15) C3 0.0382(17) 0.056(2) 0.0317(16) -0.0015(16) -0.0032(13) -0.0014(15) C4 0.0347(16) 0.0421(18) 0.0337(16) 0.0002(14) -0.0034(13) 0.0000(13) C5 0.0327(15) 0.0392(17) 0.0312(15) 0.0016(13) -0.0048(12) 0.0027(13) C6 0.0350(16) 0.0416(18) 0.0361(16) 0.0022(14) -0.0068(13) -0.0013(14) C7 0.0343(17) 0.0397(18) 0.0334(16) 0.0031(13) -0.0050(13) 0.0011(13) C8 0.0351(17) 0.0417(18) 0.0379(17) 0.0004(14) -0.0017(13) -0.0003(14) C9 0.048(2) 0.047(2) 0.047(2) 0.0074(17) 0.0060(16) -0.0014(16) C10 0.0436(19) 0.045(2) 0.049(2) 0.0085(16) -0.0030(16) -0.0115(16) C11 0.041(2) 0.074(3) 0.055(2) 0.000(2) 0.0022(17) -0.020(2) C12 0.044(2) 0.101(4) 0.061(3) 0.016(2) -0.011(2) -0.024(3) C13 0.066(3) 0.083(3) 0.052(2) 0.027(3) -0.011(2) -0.005(2) C14 0.0362(17) 0.0470(19) 0.0301(16) -0.0035(14) -0.0075(13) 0.0051(13) C15 0.0368(16) 0.0440(19) 0.0327(16) -0.0009(14) -0.0053(13) 0.0044(14) C16 0.0374(16) 0.0391(17) 0.0303(15) 0.0017(14) -0.0052(12) 0.0018(13) C17 0.0396(17) 0.0418(18) 0.0361(16) 0.0003(15) -0.0032(13) -0.0047(14) C18 0.0376(17) 0.0384(17) 0.0445(18) 0.0015(14) -0.0069(14) -0.0054(14) C19 0.044(2) 0.055(2) 0.047(2) 0.0005(17) -0.0096(16) -0.0078(17) C20 0.047(2) 0.062(3) 0.060(2) -0.004(2) -0.0161(19) -0.011(2) C21 0.0344(18) 0.047(2) 0.075(3) 0.0017(16) -0.0087(18) -0.0042(19) C22 0.045(2) 0.051(2) 0.056(2) -0.0036(17) 0.0028(17) 0.0034(18) C23 0.047(2) 0.049(2) 0.0436(19) -0.0052(17) -0.0050(16) -0.0010(16) C24 0.0321(16) 0.0378(17) 0.0311(15) -0.0001(13) -0.0049(12) 0.0016(13) C25 0.0354(16) 0.0380(17) 0.0301(15) 0.0001(13) -0.0044(12) 0.0008(12) C26 0.047(2) 0.0435(18) 0.0325(16) -0.0021(16) -0.0057(14) -0.0023(14) C27 0.050(2) 0.0427(18) 0.0345(16) 0.0012(16) -0.0025(14) -0.0024(14) C28 0.0353(16) 0.0424(18) 0.0325(15) 0.0005(14) -0.0018(12) -0.0032(13) C29 0.066(3) 0.047(2) 0.050(2) 0.010(2) -0.0072(19) -0.0062(17) C30 0.047(2) 0.0415(18) 0.0443(19) 0.0057(16) -0.0056(16) -0.0058(15) C31 0.0395(17) 0.0430(19) 0.0370(17) -0.0019(15) -0.0093(14) 0.0063(14) C32 0.045(2) 0.047(2) 0.0417(19) -0.0010(16) -0.0027(15) 0.0098(16) C33 0.0410(19) 0.054(2) 0.0388(18) -0.0036(16) -0.0036(14) 0.0083(16) C34 0.0406(19) 0.067(3) 0.052(2) -0.0089(19) -0.0069(16) 0.004(2) C35 0.047(2) 0.065(3) 0.043(2) -0.0089(19) 0.0029(16) 0.0107(18) C36 0.0374(17) 0.051(2) 0.0332(16) 0.0000(15) 0.0001(13) 0.0052(14) C37 0.0357(17) 0.0438(18) 0.0330(16) -0.0008(14) -0.0033(13) -0.0001(13) C38 0.0379(17) 0.0463(19) 0.0438(18) 0.0024(15) -0.0014(14) 0.0014(15) C40 0.056(3) 0.095(4) 0.062(3) -0.024(3) -0.003(2) 0.016(3) C41 0.060(3) 0.087(4) 0.079(3) 0.009(3) 0.004(3) -0.009(3) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_site_symmetry_2 _geom_bond_distance _geom_bond_publ_flag Br1 C1 . 1.884(4) ? O1 N4 . 1.424(4) ? O1 H25 . 0.84 ? O2 N5 . 1.440(4) ? O2 H26 . 0.84 ? O3 C31 . 1.237(5) ? O4 C41 . 1.347(7) ? O4 H44 . 0.84 ? N1 C14 . 1.362(5) ? N1 C4 . 1.428(5) ? N1 C5 . 1.501(4) ? N2 C5 . 1.448(4) ? N2 C17 . 1.469(5) ? N2 C6 . 1.478(4) ? N3 C9 . 1.464(5) ? N3 C27 . 1.472(5) ? N3 C8 . 1.499(5) ? N4 C28 . 1.277(5) ? N5 C24 . 1.469(4) ? N5 H42 . 0.88 ? O5 C40 . 1.388(6) ? O5 H45 . 0.84 ? C1 C2 . 1.379(6) ? C1 C38 . 1.383(6) ? C2 C3 . 1.378(6) ? C2 H2 . 0.95 ? C3 C4 . 1.395(5) ? C3 H3 . 0.95 ? C4 C37 . 1.394(5) ? C5 C24 . 1.546(5) ? C5 H12 . 1.0 ? C6 C7 . 1.528(5) ? C6 H4 . 0.99 ? C6 H27 . 0.99 ? C7 C16 . 1.546(5) ? C7 C8 . 1.547(5) ? C7 H28 . 1.0 ? C8 C28 . 1.504(5) ? C8 H15 . 1.0 ? C9 C10 . 1.515(6) ? C9 H17 . 0.99 ? C9 H16 . 0.99 ? C10 C30 . 1.375(6) ? C10 C11 . 1.400(6) ? C11 C12 . 1.394(8) ? C11 H21 . 0.95 ? C12 C13 . 1.375(9) ? C12 H20 . 0.95 ? C13 C29 . 1.374(7) ? C13 H1 . 0.95 ? C14 C15 . 1.374(6) ? C14 C36 . 1.519(5) ? C15 C31 . 1.434(5) ? C15 C16 . 1.515(5) ? C16 C24 . 1.536(5) ? C16 H29 . 1.0 ? C17 C18 . 1.510(5) ? C17 H11 . 0.99 ? C17 H5 . 0.99 ? C18 C23 . 1.386(6) ? C18 C19 . 1.399(5) ? C19 C20 . 1.402(6) ? C19 H6 . 0.95 ? C20 C21 . 1.364(7) ? C20 H10 . 0.95 ? C21 C22 . 1.388(7) ? C21 H7 . 0.95 ? C22 C23 . 1.381(6) ? C22 H9 . 0.95 ? C23 H8 . 0.95 ? C24 C25 . 1.561(5) ? C25 C28 . 1.497(5) ? C25 C26 . 1.568(5) ? C25 H24 . 1.0 ? C26 C27 . 1.524(6) ? C26 H14 . 0.99 ? C26 H13 . 0.99 ? C27 H23 . 0.99 ? C27 H22 . 0.99 ? C29 C30 . 1.402(6) ? C29 H18 . 0.95 ? C30 H19 . 0.95 ? C31 C32 . 1.513(5) ? C32 C33 . 1.526(6) ? C32 H31 . 0.99 ? C32 H30 . 0.99 ? C33 C35 . 1.528(5) ? C33 C36 . 1.534(6) ? C33 C34 . 1.539(5) ? C34 H32 . 0.98 ? C34 H34 . 0.98 ? C34 H33 . 0.98 ? C35 H35 . 0.98 ? C35 H37 . 0.98 ? C35 H36 . 0.98 ? C36 H39 . 0.99 ? C36 H38 . 0.99 ? C37 C38 . 1.383(5) ? C37 H41 . 0.95 ? C38 H40 . 0.95 ? C40 H47 . 0.98 ? C40 H46 . 0.98 ? C40 H43 . 0.98 ? C41 H50 . 0.98 ? C41 H49 . 0.98 ? C41 H48 . 0.98 ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle _geom_angle_publ_flag N4 O1 H25 . . 109.5 ? N5 O2 H26 . . 109.5 ? C41 O4 H44 . . 109.5 ? C14 N1 C4 . . 122.9(3) ? C14 N1 C5 . . 120.4(3) ? C4 N1 C5 . . 116.6(3) ? C5 N2 C17 . . 112.4(3) ? C5 N2 C6 . . 114.1(3) ? C17 N2 C6 . . 110.2(3) ? C9 N3 C27 . . 111.5(3) ? C9 N3 C8 . . 112.2(3) ? C27 N3 C8 . . 112.6(3) ? C28 N4 O1 . . 111.7(3) ? O2 N5 C24 . . 108.1(3) ? O2 N5 H42 . . 126.0 ? C24 N5 H42 . . 126.0 ? C40 O5 H45 . . 109.5 ? C2 C1 C38 . . 122.1(4) ? C2 C1 Br1 . . 118.0(3) ? C38 C1 Br1 . . 119.8(3) ? C3 C2 C1 . . 119.0(3) ? C3 C2 H2 . . 120.5 ? C1 C2 H2 . . 120.5 ? C2 C3 C4 . . 120.2(3) ? C2 C3 H3 . . 119.9 ? C4 C3 H3 . . 119.9 ? C37 C4 C3 . . 119.9(3) ? C37 C4 N1 . . 119.4(3) ? C3 C4 N1 . . 120.6(3) ? N2 C5 N1 . . 113.1(3) ? N2 C5 C24 . . 111.6(3) ? N1 C5 C24 . . 108.6(3) ? N2 C5 H12 . . 107.8 ? N1 C5 H12 . . 107.8 ? C24 C5 H12 . . 107.8 ? N2 C6 C7 . . 111.7(3) ? N2 C6 H4 . . 109.3 ? C7 C6 H4 . . 109.3 ? N2 C6 H27 . . 109.3 ? C7 C6 H27 . . 109.3 ? H4 C6 H27 . . 107.9 ? C6 C7 C16 . . 109.9(3) ? C6 C7 C8 . . 110.7(3) ? C16 C7 C8 . . 110.5(3) ? C6 C7 H28 . . 108.5 ? C16 C7 H28 . . 108.5 ? C8 C7 H28 . . 108.5 ? N3 C8 C28 . . 108.4(3) ? N3 C8 C7 . . 110.0(3) ? C28 C8 C7 . . 109.2(3) ? N3 C8 H15 . . 109.7 ? C28 C8 H15 . . 109.7 ? C7 C8 H15 . . 109.7 ? N3 C9 C10 . . 112.6(3) ? N3 C9 H17 . . 109.1 ? C10 C9 H17 . . 109.1 ? N3 C9 H16 . . 109.1 ? C10 C9 H16 . . 109.1 ? H17 C9 H16 . . 107.8 ? C30 C10 C11 . . 118.0(4) ? C30 C10 C9 . . 121.5(4) ? C11 C10 C9 . . 120.3(4) ? C12 C11 C10 . . 120.2(5) ? C12 C11 H21 . . 119.9 ? C10 C11 H21 . . 119.9 ? C13 C12 C11 . . 120.6(5) ? C13 C12 H20 . . 119.7 ? C11 C12 H20 . . 119.7 ? C29 C13 C12 . . 120.1(5) ? C29 C13 H1 . . 120.0 ? C12 C13 H1 . . 120.0 ? N1 C14 C15 . . 121.2(3) ? N1 C14 C36 . . 117.6(3) ? C15 C14 C36 . . 121.2(3) ? C14 C15 C31 . . 121.2(3) ? C14 C15 C16 . . 120.8(3) ? C31 C15 C16 . . 118.0(3) ? C15 C16 C24 . . 109.8(3) ? C15 C16 C7 . . 112.8(3) ? C24 C16 C7 . . 107.0(3) ? C15 C16 H29 . . 109.0 ? C24 C16 H29 . . 109.0 ? C7 C16 H29 . . 109.0 ? N2 C17 C18 . . 113.4(3) ? N2 C17 H11 . . 108.9 ? C18 C17 H11 . . 108.9 ? N2 C17 H5 . . 108.9 ? C18 C17 H5 . . 108.9 ? H11 C17 H5 . . 107.7 ? C23 C18 C19 . . 118.7(4) ? C23 C18 C17 . . 121.6(3) ? C19 C18 C17 . . 119.7(4) ? C18 C19 C20 . . 120.0(4) ? C18 C19 H6 . . 120.0 ? C20 C19 H6 . . 120.0 ? C21 C20 C19 . . 120.4(4) ? C21 C20 H10 . . 119.8 ? C19 C20 H10 . . 119.8 ? C20 C21 C22 . . 119.8(4) ? C20 C21 H7 . . 120.1 ? C22 C21 H7 . . 120.1 ? C23 C22 C21 . . 120.4(4) ? C23 C22 H9 . . 119.8 ? C21 C22 H9 . . 119.8 ? C22 C23 C18 . . 120.7(4) ? C22 C23 H8 . . 119.6 ? C18 C23 H8 . . 119.6 ? N5 C24 C16 . . 108.8(3) ? N5 C24 C5 . . 108.0(3) ? C16 C24 C5 . . 105.3(3) ? N5 C24 C25 . . 110.9(3) ? C16 C24 C25 . . 111.8(3) ? C5 C24 C25 . . 111.9(3) ? C28 C25 C24 . . 111.3(3) ? C28 C25 C26 . . 104.5(3) ? C24 C25 C26 . . 111.8(3) ? C28 C25 H24 . . 109.7 ? C24 C25 H24 . . 109.7 ? C26 C25 H24 . . 109.7 ? C27 C26 C25 . . 112.7(3) ? C27 C26 H14 . . 109.0 ? C25 C26 H14 . . 109.0 ? C27 C26 H13 . . 109.0 ? C25 C26 H13 . . 109.0 ? H14 C26 H13 . . 107.8 ? N3 C27 C26 . . 111.5(3) ? N3 C27 H23 . . 109.3 ? C26 C27 H23 . . 109.3 ? N3 C27 H22 . . 109.3 ? C26 C27 H22 . . 109.3 ? H23 C27 H22 . . 108.0 ? N4 C28 C25 . . 127.5(3) ? N4 C28 C8 . . 120.1(3) ? C25 C28 C8 . . 111.7(3) ? C13 C29 C30 . . 119.2(5) ? C13 C29 H18 . . 120.4 ? C30 C29 H18 . . 120.4 ? C10 C30 C29 . . 121.9(4) ? C10 C30 H19 . . 119.1 ? C29 C30 H19 . . 119.1 ? O3 C31 C15 . . 121.9(3) ? O3 C31 C32 . . 119.7(3) ? C15 C31 C32 . . 118.4(3) ? C31 C32 C33 . . 113.2(3) ? C31 C32 H31 . . 108.9 ? C33 C32 H31 . . 108.9 ? C31 C32 H30 . . 108.9 ? C33 C32 H30 . . 108.9 ? H31 C32 H30 . . 107.8 ? C32 C33 C35 . . 109.6(3) ? C32 C33 C36 . . 107.5(3) ? C35 C33 C36 . . 109.6(3) ? C32 C33 C34 . . 111.2(4) ? C35 C33 C34 . . 108.8(3) ? C36 C33 C34 . . 110.0(3) ? C33 C34 H32 . . 109.5 ? C33 C34 H34 . . 109.5 ? H32 C34 H34 . . 109.5 ? C33 C34 H33 . . 109.5 ? H32 C34 H33 . . 109.5 ? H34 C34 H33 . . 109.5 ? C33 C35 H35 . . 109.5 ? C33 C35 H37 . . 109.5 ? H35 C35 H37 . . 109.5 ? C33 C35 H36 . . 109.5 ? H35 C35 H36 . . 109.5 ? H37 C35 H36 . . 109.5 ? C14 C36 C33 . . 112.2(3) ? C14 C36 H39 . . 109.2 ? C33 C36 H39 . . 109.2 ? C14 C36 H38 . . 109.2 ? C33 C36 H38 . . 109.2 ? H39 C36 H38 . . 107.9 ? C38 C37 C4 . . 120.0(3) ? C38 C37 H41 . . 120.0 ? C4 C37 H41 . . 120.0 ? C37 C38 C1 . . 118.9(3) ? C37 C38 H40 . . 120.6 ? C1 C38 H40 . . 120.6 ? O5 C40 H47 . . 109.5 ? O5 C40 H46 . . 109.5 ? H47 C40 H46 . . 109.5 ? O5 C40 H43 . . 109.5 ? H47 C40 H43 . . 109.5 ? H46 C40 H43 . . 109.5 ? O4 C41 H50 . . 109.5 ? O4 C41 H49 . . 109.5 ? H50 C41 H49 . . 109.5 ? O4 C41 H48 . . 109.5 ? H50 C41 H48 . . 109.5 ? H49 C41 H48 . . 109.5 ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion _geom_torsion_publ_flag C38 C1 C2 C3 . . . . 1.8(6) ? Br1 C1 C2 C3 . . . . -174.3(3) ? C1 C2 C3 C4 . . . . -1.1(6) ? C2 C3 C4 C37 . . . . -0.1(6) ? C2 C3 C4 N1 . . . . 178.5(3) ? C14 N1 C4 C37 . . . . -117.7(4) ? C5 N1 C4 C37 . . . . 58.3(4) ? C14 N1 C4 C3 . . . . 63.7(5) ? C5 N1 C4 C3 . . . . -120.3(4) ? C17 N2 C5 N1 . . . . -59.5(4) ? C6 N2 C5 N1 . . . . 66.8(4) ? C17 N2 C5 C24 . . . . 177.7(3) ? C6 N2 C5 C24 . . . . -56.0(4) ? C14 N1 C5 N2 . . . . -89.1(4) ? C4 N1 C5 N2 . . . . 94.8(3) ? C14 N1 C5 C24 . . . . 35.4(4) ? C4 N1 C5 C24 . . . . -140.7(3) ? C5 N2 C6 C7 . . . . 50.2(4) ? C17 N2 C6 C7 . . . . 177.6(3) ? N2 C6 C7 C16 . . . . -52.9(4) ? N2 C6 C7 C8 . . . . 69.5(4) ? C9 N3 C8 C28 . . . . 128.9(3) ? C27 N3 C8 C28 . . . . 2.2(4) ? C9 N3 C8 C7 . . . . -111.7(3) ? C27 N3 C8 C7 . . . . 121.5(3) ? C6 C7 C8 N3 . . . . -179.1(3) ? C16 C7 C8 N3 . . . . -57.0(4) ? C6 C7 C8 C28 . . . . -60.3(4) ? C16 C7 C8 C28 . . . . 61.8(4) ? C27 N3 C9 C10 . . . . -157.5(3) ? C8 N3 C9 C10 . . . . 75.2(4) ? N3 C9 C10 C30 . . . . 42.4(5) ? N3 C9 C10 C11 . . . . -143.2(4) ? C30 C10 C11 C12 . . . . 2.4(6) ? C9 C10 C11 C12 . . . . -172.2(4) ? C10 C11 C12 C13 . . . . -0.5(7) ? C11 C12 C13 C29 . . . . -1.4(8) ? C4 N1 C14 C15 . . . . 175.6(3) ? C5 N1 C14 C15 . . . . -0.2(5) ? C4 N1 C14 C36 . . . . -2.8(5) ? C5 N1 C14 C36 . . . . -178.7(3) ? N1 C14 C15 C31 . . . . 178.0(3) ? C36 C14 C15 C31 . . . . -3.7(5) ? N1 C14 C15 C16 . . . . -5.1(5) ? C36 C14 C15 C16 . . . . 173.3(3) ? C14 C15 C16 C24 . . . . -25.8(4) ? C31 C15 C16 C24 . . . . 151.3(3) ? C14 C15 C16 C7 . . . . 93.6(4) ? C31 C15 C16 C7 . . . . -89.4(4) ? C6 C7 C16 C15 . . . . -58.9(4) ? C8 C7 C16 C15 . . . . 178.6(3) ? C6 C7 C16 C24 . . . . 62.0(3) ? C8 C7 C16 C24 . . . . -60.5(4) ? C5 N2 C17 C18 . . . . -165.0(3) ? C6 N2 C17 C18 . . . . 66.5(4) ? N2 C17 C18 C23 . . . . 46.9(5) ? N2 C17 C18 C19 . . . . -135.8(4) ? C23 C18 C19 C20 . . . . 1.6(6) ? C17 C18 C19 C20 . . . . -175.7(4) ? C18 C19 C20 C21 . . . . -2.3(7) ? C19 C20 C21 C22 . . . . 1.0(7) ? C20 C21 C22 C23 . . . . 1.0(7) ? C21 C22 C23 C18 . . . . -1.6(7) ? C19 C18 C23 C22 . . . . 0.3(6) ? C17 C18 C23 C22 . . . . 177.6(4) ? O2 N5 C24 C16 . . . . -168.6(3) ? O2 N5 C24 C5 . . . . 77.5(3) ? O2 N5 C24 C25 . . . . -45.3(4) ? C15 C16 C24 N5 . . . . -57.8(4) ? C7 C16 C24 N5 . . . . 179.4(3) ? C15 C16 C24 C5 . . . . 57.8(3) ? C7 C16 C24 C5 . . . . -65.0(3) ? C15 C16 C24 C25 . . . . 179.5(3) ? C7 C16 C24 C25 . . . . 56.7(3) ? N2 C5 C24 N5 . . . . 179.0(3) ? N1 C5 C24 N5 . . . . 53.6(3) ? N2 C5 C24 C16 . . . . 62.8(3) ? N1 C5 C24 C16 . . . . -62.5(3) ? N2 C5 C24 C25 . . . . -58.8(3) ? N1 C5 C24 C25 . . . . 175.9(3) ? N5 C24 C25 C28 . . . . -176.6(3) ? C16 C24 C25 C28 . . . . -55.0(4) ? C5 C24 C25 C28 . . . . 62.8(4) ? N5 C24 C25 C26 . . . . -60.2(4) ? C16 C24 C25 C26 . . . . 61.4(4) ? C5 C24 C25 C26 . . . . 179.2(3) ? C28 C25 C26 C27 . . . . 9.6(4) ? C24 C25 C26 C27 . . . . -110.9(3) ? C9 N3 C27 C26 . . . . 177.3(3) ? C8 N3 C27 C26 . . . . -55.5(4) ? C25 C26 C27 N3 . . . . 48.9(4) ? O1 N4 C28 C25 . . . . 3.1(5) ? O1 N4 C28 C8 . . . . 172.8(3) ? C24 C25 C28 N4 . . . . -134.5(4) ? C26 C25 C28 N4 . . . . 104.7(4) ? C24 C25 C28 C8 . . . . 55.0(4) ? C26 C25 C28 C8 . . . . -65.8(3) ? N3 C8 C28 N4 . . . . -109.7(4) ? C7 C8 C28 N4 . . . . 130.4(3) ? N3 C8 C28 C25 . . . . 61.5(4) ? C7 C8 C28 C25 . . . . -58.3(4) ? C12 C13 C29 C30 . . . . 1.2(7) ? C11 C10 C30 C29 . . . . -2.6(6) ? C9 C10 C30 C29 . . . . 171.9(4) ? C13 C29 C30 C10 . . . . 0.8(6) ? C14 C15 C31 O3 . . . . -177.5(3) ? C16 C15 C31 O3 . . . . 5.4(5) ? C14 C15 C31 C32 . . . . 2.0(5) ? C16 C15 C31 C32 . . . . -175.1(3) ? O3 C31 C32 C33 . . . . -151.4(4) ? C15 C31 C32 C33 . . . . 29.1(5) ? C31 C32 C33 C35 . . . . -174.5(3) ? C31 C32 C33 C36 . . . . -55.4(4) ? C31 C32 C33 C34 . . . . 65.1(4) ? N1 C14 C36 C33 . . . . 153.0(3) ? C15 C14 C36 C33 . . . . -25.4(5) ? C32 C33 C36 C14 . . . . 53.1(4) ? C35 C33 C36 C14 . . . . 172.2(3) ? C34 C33 C36 C14 . . . . -68.1(4) ? C3 C4 C37 C38 . . . . 0.7(6) ? N1 C4 C37 C38 . . . . -178.0(3) ? C4 C37 C38 C1 . . . . 0.0(6) ? C2 C1 C38 C37 . . . . -1.3(6) ? Br1 C1 C38 C37 . . . . 174.8(3) ? loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_site_symmetry_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_publ_flag O1 H25 O3 2_655 0.84 1.83 2.657(4) 167.5 ? O2 H26 O5 . 0.84 1.93 2.763(5) 174.6 ? O4 H44 N4 1_455 0.84 2.17 2.877(5) 142.2 ? O5 H45 O4 . 0.84 1.98 2.821(6) 176.7 ? C2 H2 O2 4_576 0.95 2.42 3.321(5) 157.6 ? C3 H3 O1 4_576 0.95 2.66 3.502(4) 148.6 ? C41 H49 Br1 4_575 0.98 3.09 3.715(6) 122.6 ? _shelx_res_file ; TITL hd_wql24_0m_a.res in P2(1)/c hd_wql24_0m.res created by SHELXL-2017/1 at 12:31:58 on 30-Jul-2019 CELL 1.54178 11.9227 17.3502 17.7857 90.000 90.611 90.000 ZERR 4.00 0.0003 0.0004 0.0004 0.000 0.001 0.000 LATT 1 SYMM -x, y+1/2, -z+1/2 SFAC C H N O BR UNIT 160 200 20 20 4 LIST 4 ! automatically inserted. Change 6 to 4 for CHECKCIF!! TEMP -173.150 SIZE 0.050 0.100 0.200 ACTA EQIV $1 -x+1, y+1/2, -z+1/2 HTAB O1 O3_$1 HTAB O2 O5 EQIV $2 x-1, y, z HTAB O4 N4_$2 HTAB O5 O4 EQIV $3 x, -y+3/2, z+1/2 HTAB C2 O2_$3 HTAB C3 O1_$3 EQIV $4 x, -y+3/2, z-1/2 HTAB C41 Br1_$4 L.S. 4 FMAP 2 PLAN -5 0 0.00 HTAB BOND $H CONF WGHT 0.161800 4.812600 FVAR 0.27217 BR1 5 0.052623 0.917367 0.517413 11.00000 0.05493 0.06486 = 0.07277 -0.02193 -0.00310 0.00821 O1 4 0.514311 0.758146 0.103665 11.00000 0.04331 0.03673 = 0.04293 0.00366 -0.00815 -0.00049 AFIX 147 H25 2 0.531535 0.804587 0.110485 11.00000 -1.50000 AFIX 0 O2 4 0.196030 0.641751 0.193197 11.00000 0.03865 0.06119 = 0.04142 0.01165 -0.00761 0.00207 AFIX 147 H26 2 0.130501 0.648956 0.208597 11.00000 -1.50000 AFIX 0 O3 4 0.458215 0.405979 0.361778 11.00000 0.04693 0.04251 = 0.04523 0.00449 -0.00451 0.00314 O4 4 -0.175988 0.753041 0.145481 11.00000 0.05698 0.09560 = 0.07337 0.00377 -0.00067 -0.00776 AFIX 147 H44 2 -0.229159 0.723439 0.156344 11.00000 -1.50000 AFIX 0 N1 3 0.321582 0.660813 0.375449 11.00000 0.03425 0.04201 = 0.03132 0.00070 -0.00288 0.00168 N2 3 0.491024 0.709787 0.313651 11.00000 0.03188 0.03616 = 0.03510 -0.00105 -0.00509 -0.00081 N3 3 0.598390 0.519137 0.166703 11.00000 0.04378 0.04378 = 0.03683 -0.00261 -0.00152 0.00678 N4 3 0.590893 0.710195 0.143999 11.00000 0.03794 0.04169 = 0.03406 -0.00042 -0.00253 0.00047 N5 3 0.253425 0.588808 0.242662 11.00000 0.03556 0.04351 = 0.03484 0.00580 -0.00768 -0.00360 AFIX 43 H42 2 0.223264 0.548812 0.265186 11.00000 -1.20000 AFIX 0 O5 4 -0.020333 0.673802 0.237635 11.00000 0.04241 0.18451 = 0.07489 0.06167 0.00183 0.01061 AFIX 147 H45 2 -0.064529 0.698225 0.209296 11.00000 -1.50000 AFIX 0 C1 1 0.129246 0.833224 0.475029 11.00000 0.04242 0.04358 = 0.04666 -0.00756 0.00742 -0.00136 C2 1 0.216818 0.801297 0.515623 11.00000 0.04138 0.05146 = 0.03801 -0.00575 -0.00141 -0.00573 AFIX 43 H2 2 0.233095 0.818349 0.565311 11.00000 -1.20000 AFIX 0 C3 1 0.280353 0.744257 0.482961 11.00000 0.03817 0.05587 = 0.03169 -0.00141 -0.00315 -0.00145 AFIX 43 H3 2 0.341758 0.722352 0.509900 11.00000 -1.20000 AFIX 0 C4 1 0.254722 0.718613 0.410462 11.00000 0.03469 0.04206 = 0.03368 -0.00004 -0.00339 0.00021 C5 1 0.376952 0.682817 0.303166 11.00000 0.03271 0.03918 = 0.03121 0.00271 -0.00485 0.00155 AFIX 13 H12 2 0.332480 0.725740 0.280059 11.00000 -1.20000 AFIX 0 C6 1 0.569987 0.649853 0.340360 11.00000 0.03497 0.04165 = 0.03612 -0.00130 -0.00679 0.00221 AFIX 23 H4 2 0.553341 0.637064 0.393328 11.00000 -1.20000 H27 2 0.647487 0.670197 0.338519 11.00000 -1.20000 AFIX 0 C7 1 0.562014 0.576747 0.292677 11.00000 0.03426 0.03972 = 0.03343 0.00105 -0.00498 0.00309 AFIX 13 H28 2 0.608000 0.535575 0.317459 11.00000 -1.20000 AFIX 0 C8 1 0.608591 0.591050 0.213009 11.00000 0.03512 0.04174 = 0.03793 -0.00031 -0.00172 0.00045 AFIX 13 H15 2 0.689081 0.606952 0.216693 11.00000 -1.20000 AFIX 0 C9 1 0.707814 0.485369 0.149995 11.00000 0.04770 0.04710 = 0.04705 -0.00136 0.00600 0.00737 AFIX 23 H17 2 0.759145 0.526655 0.133263 11.00000 -1.20000 H16 2 0.699064 0.448175 0.108130 11.00000 -1.20000 AFIX 0 C10 1 0.759742 0.444517 0.217124 11.00000 0.04357 0.04468 = 0.04876 -0.01147 -0.00304 0.00848 C11 1 0.875714 0.447655 0.229949 11.00000 0.04106 0.07396 = 0.05520 -0.01987 0.00221 0.00031 AFIX 43 H21 2 0.920961 0.480596 0.200263 11.00000 -1.20000 AFIX 0 C12 1 0.924999 0.402572 0.286168 11.00000 0.04360 0.10116 = 0.06073 -0.02364 -0.01051 0.01638 AFIX 43 H20 2 1.003824 0.404713 0.294271 11.00000 -1.20000 AFIX 0 C13 1 0.860545 0.355053 0.329975 11.00000 0.06596 0.08267 = 0.05177 -0.00509 -0.01125 0.02651 AFIX 43 H1 2 0.895111 0.323715 0.367392 11.00000 -1.20000 AFIX 0 C14 1 0.330554 0.587555 0.402437 11.00000 0.03624 0.04702 = 0.03008 0.00510 -0.00751 -0.00345 C15 1 0.389669 0.532174 0.364424 11.00000 0.03681 0.04397 = 0.03270 0.00442 -0.00529 -0.00088 C16 1 0.438850 0.549060 0.287988 11.00000 0.03739 0.03909 = 0.03031 0.00182 -0.00519 0.00171 AFIX 13 H29 2 0.434939 0.501349 0.256525 11.00000 -1.20000 AFIX 0 C17 1 0.497649 0.777857 0.362595 11.00000 0.03957 0.04184 = 0.03612 -0.00465 -0.00319 0.00034 AFIX 23 H11 2 0.484808 0.761656 0.415177 11.00000 -1.20000 H5 2 0.437008 0.814128 0.348231 11.00000 -1.20000 AFIX 0 C18 1 0.608750 0.819342 0.358665 11.00000 0.03763 0.03836 = 0.04453 -0.00536 -0.00688 0.00147 C19 1 0.661497 0.844218 0.424961 11.00000 0.04384 0.05497 = 0.04664 -0.00776 -0.00965 0.00055 AFIX 43 H6 2 0.629995 0.831952 0.472317 11.00000 -1.20000 AFIX 0 C20 1 0.760818 0.887238 0.421551 11.00000 0.04675 0.06213 = 0.05996 -0.01150 -0.01607 -0.00424 AFIX 43 H10 2 0.794981 0.905639 0.466588 11.00000 -1.20000 AFIX 0 C21 1 0.808692 0.902827 0.353906 11.00000 0.03440 0.04720 = 0.07492 -0.00422 -0.00868 0.00175 AFIX 43 H7 2 0.876626 0.931330 0.351886 11.00000 -1.20000 AFIX 0 C22 1 0.757837 0.876913 0.288018 11.00000 0.04485 0.05082 = 0.05572 0.00343 0.00281 -0.00358 AFIX 43 H9 2 0.791785 0.887077 0.240965 11.00000 -1.20000 AFIX 0 C23 1 0.658203 0.836453 0.290483 11.00000 0.04709 0.04905 = 0.04361 -0.00099 -0.00497 -0.00519 AFIX 43 H8 2 0.623174 0.820171 0.244963 11.00000 -1.20000 AFIX 0 C24 1 0.371163 0.613231 0.248960 11.00000 0.03208 0.03784 = 0.03112 0.00156 -0.00489 -0.00013 C25 1 0.419329 0.633238 0.170083 11.00000 0.03537 0.03797 = 0.03014 0.00078 -0.00436 0.00008 AFIX 13 H24 2 0.376341 0.677192 0.147585 11.00000 -1.20000 AFIX 0 C26 1 0.414925 0.562295 0.115522 11.00000 0.04741 0.04347 = 0.03255 -0.00232 -0.00567 -0.00214 AFIX 23 H14 2 0.369495 0.520998 0.138608 11.00000 -1.20000 H13 2 0.377268 0.577833 0.068015 11.00000 -1.20000 AFIX 0 C27 1 0.530885 0.530638 0.097848 11.00000 0.05050 0.04270 = 0.03450 -0.00244 -0.00250 0.00116 AFIX 23 H23 2 0.522910 0.480884 0.071070 11.00000 -1.20000 H22 2 0.570145 0.566983 0.064236 11.00000 -1.20000 AFIX 0 C28 1 0.541189 0.653626 0.175277 11.00000 0.03529 0.04243 = 0.03255 -0.00322 -0.00183 0.00045 C29 1 0.746165 0.352821 0.319712 11.00000 0.06571 0.04739 = 0.04968 -0.00618 -0.00724 0.00970 AFIX 43 H18 2 0.701108 0.320845 0.350500 11.00000 -1.20000 AFIX 0 C30 1 0.696825 0.398318 0.263244 11.00000 0.04697 0.04147 = 0.04431 -0.00581 -0.00555 0.00565 AFIX 43 H19 2 0.617666 0.397205 0.256650 11.00000 -1.20000 AFIX 0 C31 1 0.402116 0.455732 0.394081 11.00000 0.03946 0.04301 = 0.03700 0.00633 -0.00925 -0.00192 C32 1 0.345227 0.436412 0.467348 11.00000 0.04543 0.04692 = 0.04167 0.00982 -0.00274 -0.00103 AFIX 23 H31 2 0.398458 0.445900 0.509436 11.00000 -1.20000 H30 2 0.326046 0.380896 0.467573 11.00000 -1.20000 AFIX 0 C33 1 0.238799 0.483226 0.480297 11.00000 0.04102 0.05382 = 0.03878 0.00825 -0.00356 -0.00364 C34 1 0.147778 0.463707 0.421286 11.00000 0.04065 0.06718 = 0.05153 0.00433 -0.00693 -0.00891 AFIX 137 H32 2 0.175413 0.475948 0.370983 11.00000 -1.50000 H34 2 0.080231 0.494067 0.431238 11.00000 -1.50000 H33 2 0.129744 0.408681 0.424070 11.00000 -1.50000 AFIX 0 C35 1 0.193354 0.465850 0.558516 11.00000 0.04680 0.06452 = 0.04295 0.01070 0.00293 -0.00894 AFIX 137 H35 2 0.172305 0.411345 0.561513 11.00000 -1.50000 H37 2 0.127324 0.497990 0.567739 11.00000 -1.50000 H36 2 0.251295 0.477072 0.596451 11.00000 -1.50000 AFIX 0 C36 1 0.270252 0.568782 0.474992 11.00000 0.03744 0.05116 = 0.03317 0.00518 0.00006 -0.00005 AFIX 23 H39 2 0.201281 0.600354 0.478008 11.00000 -1.20000 H38 2 0.319171 0.582567 0.518263 11.00000 -1.20000 AFIX 0 C37 1 0.164498 0.750624 0.370978 11.00000 0.03574 0.04381 = 0.03303 -0.00010 -0.00329 -0.00076 AFIX 43 H41 2 0.146463 0.732815 0.321808 11.00000 -1.20000 AFIX 0 C38 1 0.101243 0.808308 0.403391 11.00000 0.03792 0.04631 = 0.04379 0.00135 -0.00141 0.00237 AFIX 43 H40 2 0.039592 0.830449 0.376899 11.00000 -1.20000 AFIX 0 C40 1 -0.075784 0.652347 0.302574 11.00000 0.05608 0.09461 = 0.06231 0.01597 -0.00261 -0.02396 AFIX 137 H47 2 -0.020898 0.635663 0.340617 11.00000 -1.50000 H46 2 -0.127365 0.609843 0.291187 11.00000 -1.50000 H43 2 -0.118245 0.696385 0.321774 11.00000 -1.50000 AFIX 0 C41 1 -0.142269 0.738484 0.074826 11.00000 0.05983 0.08695 = 0.07881 -0.00899 0.00350 0.00941 AFIX 137 H50 2 -0.189244 0.767426 0.039171 11.00000 -1.50000 H49 2 -0.149209 0.683203 0.064469 11.00000 -1.50000 H48 2 -0.063828 0.754236 0.069447 11.00000 -1.50000 REM ##### REM ##### AFIX 0 HKLF 4 1 1 0 0 0 1 0 0 0 1 REM hd_wql24_0m_a.res in P2(1)/c REM R1 = 0.0814 for 6204 Fo > 4sig(Fo) and 0.0897 for all 7252 data REM 468 parameters refined using 0 restraints END WGHT 0.1618 4.8109 REM Instructions for potential hydrogen bonds HTAB O1 O3_$1 HTAB O2 O5 HTAB O4 N4_$2 HTAB O5 O4 HTAB C2 O2_$3 HTAB C3 O1_$3 HTAB C41 Br1_$4 REM Highest difference peak 1.901, deepest hole -1.272, 1-sigma level 0.115 Q1 1 -0.1776 0.6891 0.1210 11.00000 0.05 1.90 Q2 1 0.0058 0.8837 0.5384 11.00000 0.05 1.73 Q3 1 0.0256 0.9591 0.5043 11.00000 0.05 1.10 Q4 1 0.2516 0.5432 0.2193 11.00000 0.05 0.69 Q5 1 0.0933 0.8608 0.4947 11.00000 0.05 0.59 ; _shelx_res_checksum 88460 ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_201809377 _database_code_depnum_ccdc_archive 'CCDC 1947690' loop_ _audit_author_name _audit_author_address 'Qilin Wang' ;Henan University China ; _audit_update_record ; 2019-08-17 deposited with the CCDC. 2019-12-17 downloaded from the CCDC. ; _audit_creation_date 2018-09-19 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic ? _chemical_formula_moiety 'C29 H27 Cl N2 O' _chemical_formula_sum 'C29 H27 Cl N2 O' _chemical_formula_weight 454.97 _chemical_melting_point ? _chemical_oxdiff_formula C15H15O3N2 loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' Cl Cl 0.3639 0.7018 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system monoclinic _space_group_IT_number 14 _space_group_name_H-M_alt 'P 1 21/c 1' _space_group_name_Hall '-P 2ybc' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y-1/2, z-1/2' _cell_length_a 10.8554(2) _cell_length_b 18.2505(2) _cell_length_c 12.2873(2) _cell_angle_alpha 90 _cell_angle_beta 105.0100(10) _cell_angle_gamma 90 _cell_volume 2351.26(6) _cell_formula_units_Z 4 _cell_measurement_reflns_used 6504 _cell_measurement_temperature 293(2) _cell_measurement_theta_max 70.8490 _cell_measurement_theta_min 4.4320 _shelx_estimated_absorpt_T_max 0.855 _shelx_estimated_absorpt_T_min 0.793 _exptl_absorpt_coefficient_mu 1.619 _exptl_absorpt_correction_T_max 1.00000 _exptl_absorpt_correction_T_min 0.92914 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. ; _exptl_absorpt_special_details ? _exptl_crystal_colour colourless _exptl_crystal_colour_primary colourless _exptl_crystal_density_diffrn 1.285 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description prism _exptl_crystal_F_000 960 _exptl_crystal_size_max 0.15 _exptl_crystal_size_mid 0.12 _exptl_crystal_size_min 0.1 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0306 _diffrn_reflns_av_unetI/netI 0.0227 _diffrn_reflns_Laue_measured_fraction_full 1.000 _diffrn_reflns_Laue_measured_fraction_max 1.000 _diffrn_reflns_limit_h_max 8 _diffrn_reflns_limit_h_min -12 _diffrn_reflns_limit_k_max 21 _diffrn_reflns_limit_k_min -21 _diffrn_reflns_limit_l_max 14 _diffrn_reflns_limit_l_min -14 _diffrn_reflns_number 17116 _diffrn_reflns_point_group_measured_fraction_full 1.000 _diffrn_reflns_point_group_measured_fraction_max 1.000 _diffrn_reflns_theta_full 67.066 _diffrn_reflns_theta_max 67.066 _diffrn_reflns_theta_min 4.217 _diffrn_ambient_temperature 293(2) _diffrn_detector 'CCD plate' _diffrn_detector_area_resol_mean 16.2312 _diffrn_detector_type Eos _diffrn_measured_fraction_theta_full 1.000 _diffrn_measured_fraction_theta_max 1.000 _diffrn_measurement_details ; #__ type_ start__ end____ width___ exp.time_ 1 omega -68.00 -42.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 -120.0000 52 #__ type_ start__ end____ width___ exp.time_ 2 omega -108.00 -75.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 -120.0000 66 #__ type_ start__ end____ width___ exp.time_ 3 omega -77.00 -51.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 60.0000 52 #__ type_ start__ end____ width___ exp.time_ 4 omega -100.00 -66.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 -77.0000 -60.0000 68 #__ type_ start__ end____ width___ exp.time_ 5 omega 50.00 77.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 30.0000 54 #__ type_ start__ end____ width___ exp.time_ 6 omega 58.00 83.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -180.0000 50 #__ type_ start__ end____ width___ exp.time_ 7 omega -33.00 57.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -37.0000 -150.0000 180 #__ type_ start__ end____ width___ exp.time_ 8 omega -33.00 3.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -77.0000 150.0000 72 #__ type_ start__ end____ width___ exp.time_ 9 omega 19.00 55.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 77.0000 -120.0000 72 #__ type_ start__ end____ width___ exp.time_ 10 omega -33.00 55.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -77.0000 -180.0000 176 #__ type_ start__ end____ width___ exp.time_ 11 omega 8.00 37.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 77.0000 -150.0000 58 #__ type_ start__ end____ width___ exp.time_ 12 omega -3.00 25.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 30.0000 56 #__ type_ start__ end____ width___ exp.time_ 13 omega -31.00 26.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -77.0000 60.0000 114 #__ type_ start__ end____ width___ exp.time_ 14 omega 58.00 108.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -150.0000 100 #__ type_ start__ end____ width___ exp.time_ 15 omega 76.00 102.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 57.0000 -90.0000 52 #__ type_ start__ end____ width___ exp.time_ 16 omega 59.00 101.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 77.0000 -150.0000 84 #__ type_ start__ end____ width___ exp.time_ 17 omega 40.00 65.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -77.0000 60.0000 50 #__ type_ start__ end____ width___ exp.time_ 18 omega 23.00 68.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 57.0000 30.0000 90 #__ type_ start__ end____ width___ exp.time_ 19 omega -1.00 52.00 0.5000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -57.0000 -180.0000 106 #__ type_ start__ end____ width___ exp.time_ 20 omega 38.00 85.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 90.0000 94 #__ type_ start__ end____ width___ exp.time_ 21 omega 40.00 67.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 -180.0000 54 #__ type_ start__ end____ width___ exp.time_ 22 omega 65.00 99.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 120.0000 68 #__ type_ start__ end____ width___ exp.time_ 23 omega 70.00 109.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 150.0000 78 #__ type_ start__ end____ width___ exp.time_ 24 omega 107.00 144.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 178.0000 120.0000 74 #__ type_ start__ end____ width___ exp.time_ 25 omega 61.00 97.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 178.0000 120.0000 72 #__ type_ start__ end____ width___ exp.time_ 26 omega 45.00 153.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -15.0000 0.0000 216 #__ type_ start__ end____ width___ exp.time_ 27 omega 55.00 111.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 90.0000 112 #__ type_ start__ end____ width___ exp.time_ 28 omega 49.00 95.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 -150.0000 92 #__ type_ start__ end____ width___ exp.time_ 29 omega 49.00 115.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 -90.0000 132 #__ type_ start__ end____ width___ exp.time_ 30 omega 44.00 131.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -77.0000 -30.0000 174 #__ type_ start__ end____ width___ exp.time_ 31 omega 41.00 124.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -61.0000 60.0000 166 #__ type_ start__ end____ width___ exp.time_ 32 omega 96.00 137.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 45.0000 0.0000 82 #__ type_ start__ end____ width___ exp.time_ 33 omega 43.00 91.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 -120.0000 96 #__ type_ start__ end____ width___ exp.time_ 34 omega 37.00 87.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 -30.0000 100 #__ type_ start__ end____ width___ exp.time_ 35 omega 43.00 151.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -15.0000 120.0000 216 #__ type_ start__ end____ width___ exp.time_ 36 omega 79.00 137.00 0.5000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -77.0000 -120.0000 116 ; _diffrn_measurement_device 'four-circle diffractometer' _diffrn_measurement_device_type 'Xcalibur, Eos, Gemini' _diffrn_measurement_method '\w scans' _diffrn_orient_matrix_UB_11 0.0226261000 _diffrn_orient_matrix_UB_12 -0.0808169000 _diffrn_orient_matrix_UB_13 -0.0252511000 _diffrn_orient_matrix_UB_21 0.0588653000 _diffrn_orient_matrix_UB_22 -0.0138223000 _diffrn_orient_matrix_UB_23 0.1264910000 _diffrn_orient_matrix_UB_31 -0.1327522000 _diffrn_orient_matrix_UB_32 -0.0199418000 _diffrn_orient_matrix_UB_33 0.0146024000 _diffrn_radiation_monochromator graphite _diffrn_radiation_probe x-ray _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54184 _diffrn_source 'Enhance (Cu) X-ray Source' _reflns_Friedel_coverage 0.000 _reflns_Friedel_fraction_full . _reflns_Friedel_fraction_max . _reflns_number_gt 3540 _reflns_number_total 4192 _reflns_odcompleteness_completeness 99.98 _reflns_odcompleteness_iscentric 1 _reflns_odcompleteness_theta 66.97 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_collection ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_reduction ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution 'ShelXT (Sheldrick, 2015)' _refine_diff_density_max 0.296 _refine_diff_density_min -0.356 _refine_diff_density_rms 0.048 _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.044 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 299 _refine_ls_number_reflns 4192 _refine_ls_number_restraints 0 _refine_ls_R_factor_all 0.0555 _refine_ls_R_factor_gt 0.0474 _refine_ls_restrained_S_all 1.044 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0779P)^2^+0.3819P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1290 _refine_ls_wR_factor_ref 0.1396 _refine_special_details ? _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups At 1.5 times of: All C(H,H,H) groups 2.a Ternary CH refined with riding coordinates: C20(H20), C22(H22) 2.b Secondary CH2 refined with riding coordinates: C2(H2A,H2B), C3(H3A,H3B), C4(H4A,H4B), C21(H21A,H21B), C23(H23A,H23B) 2.c Aromatic/amide H refined with riding coordinates: C8(H8), C9(H9), C11(H11), C12(H12), C14(H14), C16(H16), C17(H17), C25(H25), C26(H26), C27(H27), C28(H28), C29(H29) 2.d Idealised Me refined as rotating group: C13(H13A,H13B,H13C) ; _atom_sites_solution_hydrogens geom _atom_sites_solution_primary dual _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C1 C 0.42105(17) 0.36319(9) 0.65974(15) 0.0495(4) Uani 1 1 d . . . . . C2 C 0.29308(18) 0.40142(11) 0.63079(17) 0.0597(5) Uani 1 1 d . . . . . H2A H 0.2450 0.3858 0.6831 0.072 Uiso 1 1 calc R . . . . H2B H 0.3064 0.4539 0.6397 0.072 Uiso 1 1 calc R . . . . C3 C 0.21633(17) 0.38546(12) 0.51183(18) 0.0635(5) Uani 1 1 d . . . . . H3A H 0.1388 0.4144 0.4947 0.076 Uiso 1 1 calc R . . . . H3B H 0.1925 0.3341 0.5052 0.076 Uiso 1 1 calc R . . . . C4 C 0.29354(16) 0.40352(11) 0.42864(16) 0.0577(4) Uani 1 1 d . . . . . H4A H 0.2464 0.3889 0.3535 0.069 Uiso 1 1 calc R . . . . H4B H 0.3075 0.4560 0.4281 0.069 Uiso 1 1 calc R . . . . C5 C 0.42025(15) 0.36459(9) 0.45978(14) 0.0451(4) Uani 1 1 d . . . . . C6 C 0.47689(15) 0.34495(8) 0.56893(14) 0.0451(4) Uani 1 1 d . . . . . C7 C 0.43059(14) 0.37969(9) 0.26479(14) 0.0462(4) Uani 1 1 d . . . . . C8 C 0.43820(17) 0.45425(10) 0.24890(16) 0.0554(4) Uani 1 1 d . . . . . H8 H 0.4708 0.4847 0.3103 0.066 Uiso 1 1 calc R . . . . C9 C 0.3975(2) 0.48372(12) 0.14196(18) 0.0645(5) Uani 1 1 d . . . . . H9 H 0.4024 0.5341 0.1324 0.077 Uiso 1 1 calc R . . . . C10 C 0.34956(18) 0.43986(13) 0.04899(17) 0.0651(5) Uani 1 1 d . . . . . C11 C 0.34273(19) 0.36506(13) 0.06613(17) 0.0665(5) Uani 1 1 d . . . . . H11 H 0.3110 0.3345 0.0047 0.080 Uiso 1 1 calc R . . . . C12 C 0.38214(17) 0.33494(11) 0.17281(16) 0.0565(4) Uani 1 1 d . . . . . H12 H 0.3761 0.2847 0.1827 0.068 Uiso 1 1 calc R . . . . C13 C 0.3059(3) 0.4724(2) -0.0678(2) 0.0989(9) Uani 1 1 d . . . . . H13A H 0.3191 0.5245 -0.0637 0.148 Uiso 1 1 calc GR . . . . H13B H 0.2170 0.4622 -0.0986 0.148 Uiso 1 1 calc GR . . . . H13C H 0.3541 0.4513 -0.1153 0.148 Uiso 1 1 calc GR . . . . C14 C 0.77009(17) 0.38566(11) 0.71735(15) 0.0554(4) Uani 1 1 d . . . . . H14 H 0.7364 0.3739 0.7774 0.066 Uiso 1 1 calc R . . . . C15 C 0.87433(18) 0.43174(12) 0.73463(18) 0.0636(5) Uani 1 1 d . . . . . C16 C 0.92816(18) 0.44753(11) 0.6480(2) 0.0652(5) Uani 1 1 d . . . . . H16 H 1.0005 0.4769 0.6607 0.078 Uiso 1 1 calc R . . . . C17 C 0.87458(17) 0.41959(11) 0.54219(18) 0.0588(4) Uani 1 1 d . . . . . H17 H 0.9118 0.4302 0.4838 0.071 Uiso 1 1 calc R . . . . C18 C 0.76530(15) 0.37553(9) 0.52058(14) 0.0472(4) Uani 1 1 d . . . . . C19 C 0.71521(15) 0.35683(9) 0.61195(14) 0.0464(4) Uani 1 1 d . . . . . C20 C 0.60264(16) 0.30481(9) 0.59503(14) 0.0474(4) Uani 1 1 d . . . . . H20 H 0.6114 0.2752 0.6631 0.057 Uiso 1 1 calc R . . . . C21 C 0.60263(17) 0.25474(9) 0.49588(15) 0.0521(4) Uani 1 1 d . . . . . H21A H 0.6803 0.2259 0.5113 0.063 Uiso 1 1 calc R . . . . H21B H 0.5303 0.2216 0.4817 0.063 Uiso 1 1 calc R . . . . C22 C 0.59410(15) 0.30409(9) 0.39571(14) 0.0479(4) Uani 1 1 d . . . . . H22 H 0.5892 0.2732 0.3295 0.057 Uiso 1 1 calc R . . . . C23 C 0.75242(18) 0.36991(11) 0.31662(16) 0.0578(4) Uani 1 1 d . . . . . H23A H 0.7730 0.4217 0.3225 0.069 Uiso 1 1 calc R . . . . H23B H 0.6831 0.3632 0.2494 0.069 Uiso 1 1 calc R . . . . C24 C 0.86749(16) 0.32859(11) 0.30102(16) 0.0556(4) Uani 1 1 d . . . . . C25 C 0.9206(3) 0.34975(17) 0.2156(2) 0.0854(7) Uani 1 1 d . . . . . H25 H 0.8871 0.3897 0.1706 0.103 Uiso 1 1 calc R . . . . C26 C 1.0229(3) 0.3121(3) 0.1962(3) 0.1198(12) Uani 1 1 d . . . . . H26 H 1.0580 0.3269 0.1383 0.144 Uiso 1 1 calc R . . . . C27 C 1.0730(3) 0.2535(2) 0.2611(4) 0.1167(13) Uani 1 1 d . . . . . H27 H 1.1415 0.2280 0.2470 0.140 Uiso 1 1 calc R . . . . C28 C 1.0226(2) 0.23220(15) 0.3469(3) 0.0959(9) Uani 1 1 d . . . . . H28 H 1.0572 0.1924 0.3919 0.115 Uiso 1 1 calc R . . . . C29 C 0.91991(19) 0.26976(12) 0.3672(2) 0.0712(6) Uani 1 1 d . . . . . H29 H 0.8861 0.2552 0.4260 0.085 Uiso 1 1 calc R . . . . Cl1 Cl 0.93898(6) 0.46743(5) 0.86881(6) 0.0994(3) Uani 1 1 d . . . . . N1 N 0.47546(13) 0.34828(8) 0.37505(12) 0.0485(3) Uani 1 1 d . . . . . N2 N 0.70744(14) 0.34915(9) 0.41348(13) 0.0538(4) Uani 1 1 d . . . . . O1 O 0.47421(15) 0.34895(8) 0.75889(11) 0.0654(4) Uani 1 1 d . . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 C1 0.0559(10) 0.0430(8) 0.0531(10) -0.0049(7) 0.0202(8) -0.0080(7) C2 0.0558(10) 0.0621(10) 0.0679(11) -0.0086(9) 0.0281(9) -0.0015(8) C3 0.0420(9) 0.0774(12) 0.0744(12) -0.0082(10) 0.0207(9) -0.0012(8) C4 0.0396(8) 0.0738(12) 0.0591(10) -0.0029(9) 0.0118(7) 0.0075(8) C5 0.0383(8) 0.0467(8) 0.0512(9) -0.0052(6) 0.0132(7) -0.0026(6) C6 0.0435(8) 0.0435(8) 0.0500(9) -0.0017(6) 0.0150(7) -0.0043(6) C7 0.0366(8) 0.0562(9) 0.0455(8) -0.0031(7) 0.0102(6) 0.0038(6) C8 0.0527(10) 0.0582(10) 0.0560(10) -0.0076(8) 0.0152(8) -0.0042(7) C9 0.0617(11) 0.0668(11) 0.0688(12) 0.0103(9) 0.0235(9) 0.0062(9) C10 0.0471(10) 0.0964(15) 0.0541(11) 0.0095(10) 0.0172(8) 0.0165(9) C11 0.0533(10) 0.0917(14) 0.0493(10) -0.0162(10) 0.0039(8) 0.0100(9) C12 0.0497(9) 0.0599(10) 0.0564(10) -0.0109(8) 0.0077(8) 0.0052(7) C13 0.0817(17) 0.153(3) 0.0623(14) 0.0276(16) 0.0186(12) 0.0237(17) C14 0.0462(9) 0.0666(10) 0.0501(9) -0.0003(8) 0.0068(7) 0.0065(8) C15 0.0468(10) 0.0726(12) 0.0632(11) -0.0138(9) -0.0005(8) 0.0042(8) C16 0.0410(9) 0.0668(11) 0.0846(14) -0.0075(10) 0.0106(9) -0.0044(8) C17 0.0430(9) 0.0649(10) 0.0702(12) 0.0028(9) 0.0178(8) 0.0007(8) C18 0.0365(8) 0.0525(8) 0.0519(9) 0.0041(7) 0.0102(7) 0.0071(6) C19 0.0387(8) 0.0501(8) 0.0481(9) 0.0044(7) 0.0073(7) 0.0080(6) C20 0.0486(9) 0.0461(8) 0.0479(9) 0.0067(7) 0.0130(7) 0.0017(7) C21 0.0506(9) 0.0449(8) 0.0611(10) -0.0006(7) 0.0147(8) 0.0044(7) C22 0.0426(8) 0.0522(9) 0.0490(9) -0.0062(7) 0.0123(7) 0.0057(7) C23 0.0503(9) 0.0748(11) 0.0506(9) 0.0082(8) 0.0170(8) 0.0080(8) C24 0.0442(9) 0.0651(10) 0.0589(10) -0.0137(8) 0.0155(8) -0.0057(7) C25 0.0796(15) 0.1117(19) 0.0765(15) -0.0049(13) 0.0407(13) 0.0023(13) C26 0.096(2) 0.168(4) 0.119(3) -0.034(3) 0.070(2) 0.004(2) C27 0.0732(17) 0.125(3) 0.162(3) -0.068(3) 0.049(2) 0.0085(17) C28 0.0618(13) 0.0714(14) 0.149(3) -0.0291(16) 0.0180(16) 0.0070(11) C29 0.0534(11) 0.0663(12) 0.0935(16) -0.0078(11) 0.0181(10) 0.0015(9) Cl1 0.0706(4) 0.1349(6) 0.0807(4) -0.0434(4) -0.0018(3) -0.0132(3) N1 0.0412(7) 0.0577(8) 0.0460(7) -0.0036(6) 0.0102(6) 0.0054(6) N2 0.0423(7) 0.0723(9) 0.0479(8) 0.0022(7) 0.0137(6) 0.0002(6) O1 0.0826(9) 0.0667(8) 0.0505(7) 0.0002(6) 0.0239(7) 0.0047(7) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag C1 C2 1.512(3) . ? C1 C6 1.440(2) . ? C1 O1 1.233(2) . ? C2 H2A 0.9700 . ? C2 H2B 0.9700 . ? C2 C3 1.512(3) . ? C3 H3A 0.9700 . ? C3 H3B 0.9700 . ? C3 C4 1.517(3) . ? C4 H4A 0.9700 . ? C4 H4B 0.9700 . ? C4 C5 1.507(2) . ? C5 C6 1.370(2) . ? C5 N1 1.362(2) . ? C6 C20 1.509(2) . ? C7 C8 1.380(3) . ? C7 C12 1.383(2) . ? C7 N1 1.435(2) . ? C8 H8 0.9300 . ? C8 C9 1.382(3) . ? C9 H9 0.9300 . ? C9 C10 1.381(3) . ? C10 C11 1.386(3) . ? C10 C13 1.512(3) . ? C11 H11 0.9300 . ? C11 C12 1.383(3) . ? C12 H12 0.9300 . ? C13 H13A 0.9600 . ? C13 H13B 0.9600 . ? C13 H13C 0.9600 . ? C14 H14 0.9300 . ? C14 C15 1.381(3) . ? C14 C19 1.382(2) . ? C15 C16 1.371(3) . ? C15 Cl1 1.742(2) . ? C16 H16 0.9300 . ? C16 C17 1.378(3) . ? C17 H17 0.9300 . ? C17 C18 1.400(3) . ? C18 C19 1.410(2) . ? C18 N2 1.389(2) . ? C19 C20 1.519(2) . ? C20 H20 0.9800 . ? C20 C21 1.523(2) . ? C21 H21A 0.9700 . ? C21 H21B 0.9700 . ? C21 C22 1.509(2) . ? C22 H22 0.9800 . ? C22 N1 1.485(2) . ? C22 N2 1.449(2) . ? C23 H23A 0.9700 . ? C23 H23B 0.9700 . ? C23 C24 1.513(2) . ? C23 N2 1.449(2) . ? C24 C25 1.377(3) . ? C24 C29 1.378(3) . ? C25 H25 0.9300 . ? C25 C26 1.378(4) . ? C26 H26 0.9300 . ? C26 C27 1.361(6) . ? C27 H27 0.9300 . ? C27 C28 1.364(5) . ? C28 H28 0.9300 . ? C28 C29 1.385(3) . ? C29 H29 0.9300 . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C6 C1 C2 118.02(16) . . ? O1 C1 C2 119.73(16) . . ? O1 C1 C6 122.25(17) . . ? C1 C2 H2A 109.1 . . ? C1 C2 H2B 109.1 . . ? H2A C2 H2B 107.9 . . ? C3 C2 C1 112.41(15) . . ? C3 C2 H2A 109.1 . . ? C3 C2 H2B 109.1 . . ? C2 C3 H3A 109.6 . . ? C2 C3 H3B 109.6 . . ? C2 C3 C4 110.34(15) . . ? H3A C3 H3B 108.1 . . ? C4 C3 H3A 109.6 . . ? C4 C3 H3B 109.6 . . ? C3 C4 H4A 109.5 . . ? C3 C4 H4B 109.5 . . ? H4A C4 H4B 108.1 . . ? C5 C4 C3 110.72(16) . . ? C5 C4 H4A 109.5 . . ? C5 C4 H4B 109.5 . . ? C6 C5 C4 121.37(15) . . ? N1 C5 C4 117.54(15) . . ? N1 C5 C6 121.07(14) . . ? C1 C6 C20 119.14(15) . . ? C5 C6 C1 121.71(15) . . ? C5 C6 C20 119.14(14) . . ? C8 C7 C12 119.37(17) . . ? C8 C7 N1 120.61(15) . . ? C12 C7 N1 120.00(16) . . ? C7 C8 H8 119.9 . . ? C7 C8 C9 120.13(18) . . ? C9 C8 H8 119.9 . . ? C8 C9 H9 119.3 . . ? C10 C9 C8 121.33(19) . . ? C10 C9 H9 119.3 . . ? C9 C10 C11 117.93(19) . . ? C9 C10 C13 121.0(2) . . ? C11 C10 C13 121.0(2) . . ? C10 C11 H11 119.3 . . ? C12 C11 C10 121.32(19) . . ? C12 C11 H11 119.3 . . ? C7 C12 H12 120.0 . . ? C11 C12 C7 119.91(18) . . ? C11 C12 H12 120.0 . . ? C10 C13 H13A 109.5 . . ? C10 C13 H13B 109.5 . . ? C10 C13 H13C 109.5 . . ? H13A C13 H13B 109.5 . . ? H13A C13 H13C 109.5 . . ? H13B C13 H13C 109.5 . . ? C15 C14 H14 119.6 . . ? C15 C14 C19 120.87(18) . . ? C19 C14 H14 119.6 . . ? C14 C15 Cl1 119.09(17) . . ? C16 C15 C14 120.37(18) . . ? C16 C15 Cl1 120.52(16) . . ? C15 C16 H16 120.2 . . ? C15 C16 C17 119.63(18) . . ? C17 C16 H16 120.2 . . ? C16 C17 H17 119.3 . . ? C16 C17 C18 121.42(18) . . ? C18 C17 H17 119.3 . . ? C17 C18 C19 118.06(16) . . ? N2 C18 C17 122.11(16) . . ? N2 C18 C19 119.82(15) . . ? C14 C19 C18 119.50(16) . . ? C14 C19 C20 120.18(15) . . ? C18 C19 C20 120.32(15) . . ? C6 C20 C19 112.17(13) . . ? C6 C20 H20 109.4 . . ? C6 C20 C21 107.98(14) . . ? C19 C20 H20 109.4 . . ? C19 C20 C21 108.54(14) . . ? C21 C20 H20 109.4 . . ? C20 C21 H21A 110.5 . . ? C20 C21 H21B 110.5 . . ? H21A C21 H21B 108.6 . . ? C22 C21 C20 106.35(13) . . ? C22 C21 H21A 110.5 . . ? C22 C21 H21B 110.5 . . ? C21 C22 H22 108.2 . . ? N1 C22 C21 109.33(13) . . ? N1 C22 H22 108.2 . . ? N2 C22 C21 110.22(14) . . ? N2 C22 H22 108.2 . . ? N2 C22 N1 112.50(14) . . ? H23A C23 H23B 107.4 . . ? C24 C23 H23A 108.3 . . ? C24 C23 H23B 108.3 . . ? N2 C23 H23A 108.3 . . ? N2 C23 H23B 108.3 . . ? N2 C23 C24 116.01(16) . . ? C25 C24 C23 118.6(2) . . ? C25 C24 C29 118.6(2) . . ? C29 C24 C23 122.81(18) . . ? C24 C25 H25 119.8 . . ? C24 C25 C26 120.5(3) . . ? C26 C25 H25 119.8 . . ? C25 C26 H26 119.7 . . ? C27 C26 C25 120.5(3) . . ? C27 C26 H26 119.7 . . ? C26 C27 H27 120.1 . . ? C26 C27 C28 119.8(2) . . ? C28 C27 H27 120.1 . . ? C27 C28 H28 120.0 . . ? C27 C28 C29 120.1(3) . . ? C29 C28 H28 120.0 . . ? C24 C29 C28 120.5(3) . . ? C24 C29 H29 119.7 . . ? C28 C29 H29 119.7 . . ? C5 N1 C7 121.69(13) . . ? C5 N1 C22 121.47(14) . . ? C7 N1 C22 116.47(13) . . ? C18 N2 C22 119.84(14) . . ? C18 N2 C23 121.44(15) . . ? C22 N2 C23 118.58(15) . . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag C1 C2 C3 C4 -54.1(2) . . . . ? C1 C6 C20 C19 -93.62(17) . . . . ? C1 C6 C20 C21 146.83(15) . . . . ? C2 C1 C6 C5 3.3(2) . . . . ? C2 C1 C6 C20 -178.22(14) . . . . ? C2 C3 C4 C5 54.0(2) . . . . ? C3 C4 C5 C6 -26.5(2) . . . . ? C3 C4 C5 N1 152.20(16) . . . . ? C4 C5 C6 C1 -2.7(2) . . . . ? C4 C5 C6 C20 178.87(15) . . . . ? C4 C5 N1 C7 12.9(2) . . . . ? C4 C5 N1 C22 -174.31(15) . . . . ? C5 C6 C20 C19 84.89(18) . . . . ? C5 C6 C20 C21 -34.67(19) . . . . ? C6 C1 C2 C3 25.6(2) . . . . ? C6 C5 N1 C7 -168.35(15) . . . . ? C6 C5 N1 C22 4.4(2) . . . . ? C6 C20 C21 C22 63.22(17) . . . . ? C7 C8 C9 C10 -0.5(3) . . . . ? C8 C7 C12 C11 0.4(3) . . . . ? C8 C7 N1 C5 64.0(2) . . . . ? C8 C7 N1 C22 -109.08(18) . . . . ? C8 C9 C10 C11 0.4(3) . . . . ? C8 C9 C10 C13 -179.62(19) . . . . ? C9 C10 C11 C12 0.2(3) . . . . ? C10 C11 C12 C7 -0.6(3) . . . . ? C12 C7 C8 C9 0.1(3) . . . . ? C12 C7 N1 C5 -117.61(18) . . . . ? C12 C7 N1 C22 69.27(19) . . . . ? C13 C10 C11 C12 -179.82(19) . . . . ? C14 C15 C16 C17 2.7(3) . . . . ? C14 C19 C20 C6 87.95(18) . . . . ? C14 C19 C20 C21 -152.82(15) . . . . ? C15 C14 C19 C18 -0.9(3) . . . . ? C15 C14 C19 C20 178.54(16) . . . . ? C15 C16 C17 C18 0.4(3) . . . . ? C16 C17 C18 C19 -3.6(3) . . . . ? C16 C17 C18 N2 177.61(17) . . . . ? C17 C18 C19 C14 3.8(2) . . . . ? C17 C18 C19 C20 -175.62(15) . . . . ? C17 C18 N2 C22 -179.67(15) . . . . ? C17 C18 N2 C23 -4.2(3) . . . . ? C18 C19 C20 C6 -92.65(18) . . . . ? C18 C19 C20 C21 26.58(19) . . . . ? C19 C14 C15 C16 -2.4(3) . . . . ? C19 C14 C15 Cl1 179.32(14) . . . . ? C19 C18 N2 C22 1.6(2) . . . . ? C19 C18 N2 C23 177.07(15) . . . . ? C19 C20 C21 C22 -58.60(17) . . . . ? C20 C21 C22 N1 -59.31(17) . . . . ? C20 C21 C22 N2 64.85(17) . . . . ? C21 C22 N1 C5 26.6(2) . . . . ? C21 C22 N1 C7 -160.30(14) . . . . ? C21 C22 N2 C18 -36.4(2) . . . . ? C21 C22 N2 C23 147.95(15) . . . . ? C23 C24 C25 C26 -177.9(3) . . . . ? C23 C24 C29 C28 177.7(2) . . . . ? C24 C23 N2 C18 80.9(2) . . . . ? C24 C23 N2 C22 -103.56(19) . . . . ? C24 C25 C26 C27 0.0(5) . . . . ? C25 C24 C29 C28 -0.9(3) . . . . ? C25 C26 C27 C28 -0.8(5) . . . . ? C26 C27 C28 C29 0.6(5) . . . . ? C27 C28 C29 C24 0.2(4) . . . . ? C29 C24 C25 C26 0.8(4) . . . . ? Cl1 C15 C16 C17 -179.12(15) . . . . ? N1 C5 C6 C1 178.64(14) . . . . ? N1 C5 C6 C20 0.2(2) . . . . ? N1 C7 C8 C9 178.47(16) . . . . ? N1 C7 C12 C11 -177.93(16) . . . . ? N1 C22 N2 C18 85.89(18) . . . . ? N1 C22 N2 C23 -89.74(18) . . . . ? N2 C18 C19 C14 -177.39(15) . . . . ? N2 C18 C19 C20 3.2(2) . . . . ? N2 C22 N1 C5 -96.24(18) . . . . ? N2 C22 N1 C7 76.89(18) . . . . ? N2 C23 C24 C25 -175.0(2) . . . . ? N2 C23 C24 C29 6.3(3) . . . . ? O1 C1 C2 C3 -154.65(17) . . . . ? O1 C1 C6 C5 -176.38(15) . . . . ? O1 C1 C6 C20 2.1(2) . . . . ? _iucr_refine_instructions_details ; 201809377.res created by SHELXL-2014/7 TITL 201809377_a.res in P2(1)/c REM Old TITL 201809377 in P21/c #14 REM SHELXT solution in P2(1)/c REM R1 0.204, Rweak 0.095, Alpha 0.031, Orientation as input REM Formula found by SHELXT: C29 N2 O Cl CELL 1.54184 10.8554 18.2505 12.2873 90 105.01 90 ZERR 4 0.0002 0.0002 0.0002 0 0.001 0 LATT 1 SYMM -X,0.5+Y,0.5-Z SFAC C H Cl N O UNIT 116 108 4 8 4 L.S. 10 0 0 PLAN 20 SIZE 0.1 0.12 0.15 MPLA C1 C2 C3 C4 C5 C6 MPLA C7 C8 C9 C10 C11 C12 MPLA C14 C15 C16 C17 C18 C19 MPLA C24 C25 C26 C27 C28 C29 MPLA C5 C6 N1 C20 C22 MPLA C20 C21 C22 MPLA C18 C19 C20 C22 N2 BOND $H list 4 conf fmap 2 acta REM REM REM WGHT 0.077900 0.381900 FVAR 0.53873 C1 1 0.421045 0.363190 0.659735 11.00000 0.05592 0.04300 = 0.05308 -0.00494 0.02017 -0.00803 C2 1 0.293083 0.401416 0.630792 11.00000 0.05583 0.06208 = 0.06788 -0.00858 0.02805 -0.00154 AFIX 23 H2A 2 0.244993 0.385764 0.683095 11.00000 -1.20000 H2B 2 0.306422 0.453864 0.639651 11.00000 -1.20000 AFIX 0 C3 1 0.216333 0.385459 0.511834 11.00000 0.04202 0.07742 = 0.07435 -0.00822 0.02072 -0.00116 AFIX 23 H3A 2 0.138767 0.414423 0.494675 11.00000 -1.20000 H3B 2 0.192541 0.334104 0.505227 11.00000 -1.20000 AFIX 0 C4 1 0.293542 0.403518 0.428639 11.00000 0.03964 0.07379 = 0.05911 -0.00294 0.01180 0.00746 AFIX 23 H4A 2 0.246374 0.388860 0.353519 11.00000 -1.20000 H4B 2 0.307456 0.456002 0.428063 11.00000 -1.20000 AFIX 0 C5 1 0.420248 0.364592 0.459781 11.00000 0.03833 0.04667 = 0.05118 -0.00518 0.01316 -0.00260 C6 1 0.476893 0.344949 0.568933 11.00000 0.04352 0.04351 = 0.05000 -0.00175 0.01505 -0.00426 C7 1 0.430585 0.379687 0.264788 11.00000 0.03658 0.05620 = 0.04550 -0.00310 0.01020 0.00376 C8 1 0.438197 0.454253 0.248896 11.00000 0.05271 0.05819 = 0.05598 -0.00756 0.01524 -0.00418 AFIX 43 H8 2 0.470792 0.484727 0.310264 11.00000 -1.20000 AFIX 0 C9 1 0.397471 0.483715 0.141961 11.00000 0.06167 0.06678 = 0.06877 0.01030 0.02353 0.00618 AFIX 43 H9 2 0.402425 0.534081 0.132400 11.00000 -1.20000 AFIX 0 C10 1 0.349557 0.439861 0.048994 11.00000 0.04708 0.09639 = 0.05410 0.00949 0.01723 0.01651 C11 1 0.342730 0.365062 0.066131 11.00000 0.05326 0.09166 = 0.04930 -0.01624 0.00386 0.00997 AFIX 43 H11 2 0.311017 0.334520 0.004668 11.00000 -1.20000 AFIX 0 C12 1 0.382136 0.334945 0.172809 11.00000 0.04971 0.05992 = 0.05645 -0.01092 0.00766 0.00524 AFIX 43 H12 2 0.376064 0.284675 0.182679 11.00000 -1.20000 AFIX 0 C13 1 0.305946 0.472423 -0.067809 11.00000 0.08172 0.15258 = 0.06235 0.02762 0.01860 0.02374 AFIX 137 H13A 2 0.319066 0.524476 -0.063695 11.00000 -1.50000 H13B 2 0.216962 0.462208 -0.098579 11.00000 -1.50000 H13C 2 0.354114 0.451264 -0.115329 11.00000 -1.50000 AFIX 0 C14 1 0.770086 0.385657 0.717348 11.00000 0.04623 0.06661 = 0.05011 -0.00028 0.00678 0.00652 AFIX 43 H14 2 0.736403 0.373881 0.777440 11.00000 -1.20000 AFIX 0 C15 1 0.874327 0.431742 0.734635 11.00000 0.04678 0.07260 = 0.06317 -0.01378 -0.00054 0.00415 C16 1 0.928162 0.447528 0.648033 11.00000 0.04095 0.06681 = 0.08461 -0.00746 0.01061 -0.00438 AFIX 43 H16 2 1.000455 0.476935 0.660657 11.00000 -1.20000 AFIX 0 C17 1 0.874575 0.419586 0.542186 11.00000 0.04300 0.06488 = 0.07019 0.00277 0.01782 0.00066 AFIX 43 H17 2 0.911778 0.430209 0.483827 11.00000 -1.20000 AFIX 0 C18 1 0.765297 0.375534 0.520580 11.00000 0.03647 0.05252 = 0.05191 0.00412 0.01024 0.00715 C19 1 0.715211 0.356827 0.611951 11.00000 0.03874 0.05015 = 0.04808 0.00443 0.00735 0.00801 C20 1 0.602641 0.304815 0.595030 11.00000 0.04858 0.04607 = 0.04792 0.00670 0.01302 0.00174 AFIX 13 H20 2 0.611377 0.275177 0.663118 11.00000 -1.20000 AFIX 0 C21 1 0.602626 0.254736 0.495880 11.00000 0.05059 0.04491 = 0.06106 -0.00062 0.01469 0.00440 AFIX 23 H21A 2 0.680298 0.225908 0.511273 11.00000 -1.20000 H21B 2 0.530282 0.221648 0.481711 11.00000 -1.20000 AFIX 0 C22 1 0.594098 0.304092 0.395711 11.00000 0.04261 0.05222 = 0.04900 -0.00621 0.01225 0.00574 AFIX 13 H22 2 0.589232 0.273205 0.329488 11.00000 -1.20000 AFIX 0 C23 1 0.752421 0.369908 0.316616 11.00000 0.05031 0.07484 = 0.05056 0.00821 0.01700 0.00802 AFIX 23 H23A 2 0.772989 0.421721 0.322503 11.00000 -1.20000 H23B 2 0.683077 0.363225 0.249446 11.00000 -1.20000 AFIX 0 C24 1 0.867486 0.328586 0.301017 11.00000 0.04417 0.06510 = 0.05888 -0.01368 0.01552 -0.00569 C25 1 0.920560 0.349750 0.215559 11.00000 0.07956 0.11167 = 0.07649 -0.00488 0.04071 0.00225 AFIX 43 H25 2 0.887096 0.389712 0.170619 11.00000 -1.20000 AFIX 0 C26 1 1.022908 0.312130 0.196166 11.00000 0.09579 0.16815 = 0.11893 -0.03351 0.07015 0.00362 AFIX 43 H26 2 1.058007 0.326929 0.138254 11.00000 -1.20000 AFIX 0 C27 1 1.073038 0.253483 0.261099 11.00000 0.07319 0.12477 = 0.16241 -0.06793 0.04917 0.00852 AFIX 43 H27 2 1.141463 0.227993 0.246989 11.00000 -1.20000 AFIX 0 C28 1 1.022626 0.232204 0.346927 11.00000 0.06178 0.07143 = 0.14940 -0.02911 0.01800 0.00702 AFIX 43 H28 2 1.057246 0.192449 0.391850 11.00000 -1.20000 AFIX 0 C29 1 0.919910 0.269764 0.367223 11.00000 0.05343 0.06629 = 0.09346 -0.00776 0.01811 0.00153 AFIX 43 H29 2 0.886078 0.255158 0.425999 11.00000 -1.20000 AFIX 0 CL1 3 0.938976 0.467429 0.868806 11.00000 0.07064 0.13489 = 0.08068 -0.04335 -0.00176 -0.01316 N1 4 0.475464 0.348283 0.375055 11.00000 0.04122 0.05767 = 0.04601 -0.00358 0.01022 0.00541 N2 4 0.707441 0.349145 0.413485 11.00000 0.04230 0.07233 = 0.04789 0.00217 0.01370 0.00018 O1 5 0.474213 0.348955 0.758890 11.00000 0.08259 0.06673 = 0.05046 0.00019 0.02389 0.00474 HKLF 4 REM 201809377_a.res in P2(1)/c REM R1 = 0.0474 for 3540 Fo > 4sig(Fo) and 0.0555 for all 4192 data REM 299 parameters refined using 0 restraints END WGHT 0.0779 0.3819 REM Highest difference peak 0.296, deepest hole -0.356, 1-sigma level 0.048 Q1 1 0.8960 0.4311 0.9052 11.00000 0.05 0.30 Q2 1 0.2633 0.4258 0.3479 11.00000 0.05 0.15 Q3 1 0.7121 0.3771 0.5613 11.00000 0.05 0.15 Q4 1 1.0240 0.4463 0.8620 11.00000 0.05 0.14 Q5 1 0.2176 0.5027 -0.0868 11.00000 0.05 0.14 Q6 1 0.7609 0.2372 0.5115 11.00000 0.05 0.14 Q7 1 0.6856 0.4672 0.3360 11.00000 0.05 0.13 Q8 1 0.3138 0.5298 0.4257 11.00000 0.05 0.13 Q9 1 0.3565 0.2678 0.2426 11.00000 0.05 0.13 Q10 1 0.8678 0.3534 0.1509 11.00000 0.05 0.12 Q11 1 0.6974 0.3937 0.7876 11.00000 0.05 0.12 Q12 1 0.4302 0.2143 0.4624 11.00000 0.05 0.12 Q13 1 0.3861 0.5102 -0.0863 11.00000 0.05 0.12 Q14 1 0.7869 0.2050 0.4142 11.00000 0.05 0.12 Q15 1 0.8938 0.1961 0.5259 11.00000 0.05 0.12 Q16 1 0.4592 0.3548 0.2025 11.00000 0.05 0.12 Q17 1 0.2541 0.4294 -0.1139 11.00000 0.05 0.12 Q18 1 0.8495 0.2363 0.3921 11.00000 0.05 0.12 Q19 1 0.9264 0.4170 0.7055 11.00000 0.05 0.12 Q20 1 0.5700 0.1541 0.5837 11.00000 0.05 0.11 REM The information below was added by Olex2. REM REM R1 = 0.0474 for 3540 Fo > 4sig(Fo) and 0.0555 for all 17447 data REM n/a parameters refined using n/a restraints REM Highest difference peak 0.30, deepest hole -0.36 REM Mean Shift 0, Max Shift 0.000. REM +++ Tabular Listing of Refinement Information +++ REM R1_all = 0.0555 REM R1_gt = 0.0474 REM wR_ref = 0.1396 REM GOOF = 1.044 REM Shift_max = 0.000 REM Shift_mean = 0 REM Reflections_all = 17447 REM Reflections_gt = 3540 REM Parameters = n/a REM Hole = -0.36 REM Peak = 0.30 REM Flack = n/a ; _olex2_submission_special_instructions 'No special instructions were received' ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_201810415 _database_code_depnum_ccdc_archive 'CCDC 1947693' loop_ _audit_author_name _audit_author_address 'Qilin Wang' ;Henan University China ; _audit_update_record ; 2019-08-17 deposited with the CCDC. 2019-12-17 downloaded from the CCDC. ; _audit_creation_date 2018-10-26 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic ? _chemical_formula_moiety 'C46 H42 Br N3 O' _chemical_formula_sum 'C46 H42 Br N3 O' _chemical_formula_weight 732.73 _chemical_melting_point ? _chemical_oxdiff_formula C15H15O3N2Br1 loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' Br Br -0.6763 1.2805 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system monoclinic _space_group_IT_number 14 _space_group_name_H-M_alt 'P 1 21/n 1' _space_group_name_Hall '-P 2yn' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x+1/2, y+1/2, -z+1/2' '-x, -y, -z' 'x-1/2, -y-1/2, z-1/2' _cell_length_a 10.2078(3) _cell_length_b 19.1520(5) _cell_length_c 18.9514(4) _cell_angle_alpha 90 _cell_angle_beta 94.804(2) _cell_angle_gamma 90 _cell_volume 3691.96(16) _cell_formula_units_Z 4 _cell_measurement_reflns_used 4592 _cell_measurement_temperature 293(2) _cell_measurement_theta_max 70.8150 _cell_measurement_theta_min 4.6030 _shelx_estimated_absorpt_T_max 0.839 _shelx_estimated_absorpt_T_min 0.735 _exptl_absorpt_coefficient_mu 1.819 _exptl_absorpt_correction_T_max ? _exptl_absorpt_correction_T_min ? _exptl_absorpt_correction_type none _exptl_absorpt_process_details ? _exptl_absorpt_special_details ? _exptl_crystal_colour colourless _exptl_crystal_colour_primary colourless _exptl_crystal_density_diffrn 1.318 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description prism _exptl_crystal_F_000 1528 _exptl_crystal_size_max 0.18 _exptl_crystal_size_mid 0.14 _exptl_crystal_size_min 0.1 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0612 _diffrn_reflns_av_unetI/netI 0.0582 _diffrn_reflns_Laue_measured_fraction_full 1.000 _diffrn_reflns_Laue_measured_fraction_max 1.000 _diffrn_reflns_limit_h_max 10 _diffrn_reflns_limit_h_min -12 _diffrn_reflns_limit_k_max 14 _diffrn_reflns_limit_k_min -22 _diffrn_reflns_limit_l_max 22 _diffrn_reflns_limit_l_min -21 _diffrn_reflns_number 14208 _diffrn_reflns_point_group_measured_fraction_full 1.000 _diffrn_reflns_point_group_measured_fraction_max 1.000 _diffrn_reflns_theta_full 67.077 _diffrn_reflns_theta_max 67.077 _diffrn_reflns_theta_min 4.618 _diffrn_ambient_temperature 293(2) _diffrn_detector 'CCD plate' _diffrn_detector_area_resol_mean 16.2312 _diffrn_detector_type Eos _diffrn_measured_fraction_theta_full 1.000 _diffrn_measured_fraction_theta_max 1.000 _diffrn_measurement_details ; #__ type_ start__ end____ width___ exp.time_ 1 omega -43.00 20.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 37.0000 150.0000 63 #__ type_ start__ end____ width___ exp.time_ 2 omega -103.00 -30.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 -77.0000 -150.0000 73 #__ type_ start__ end____ width___ exp.time_ 3 omega -57.00 -32.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 -180.0000 25 #__ type_ start__ end____ width___ exp.time_ 4 omega -108.00 -76.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 -180.0000 32 #__ type_ start__ end____ width___ exp.time_ 5 omega 58.00 109.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -90.0000 51 #__ type_ start__ end____ width___ exp.time_ 6 omega -1.00 81.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 19.0000 30.0000 82 #__ type_ start__ end____ width___ exp.time_ 7 omega 8.00 45.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 77.0000 0.0000 37 #__ type_ start__ end____ width___ exp.time_ 8 omega 1.00 39.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 -60.0000 38 #__ type_ start__ end____ width___ exp.time_ 9 omega 2.00 49.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 -120.0000 47 #__ type_ start__ end____ width___ exp.time_ 10 omega 76.00 101.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 77.0000 0.0000 25 #__ type_ start__ end____ width___ exp.time_ 11 omega 75.00 105.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 150.0000 30 #__ type_ start__ end____ width___ exp.time_ 12 omega 46.00 77.00 1.0000 1.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 -60.0000 31 #__ type_ start__ end____ width___ exp.time_ 13 omega 40.00 84.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 90.0000 44 #__ type_ start__ end____ width___ exp.time_ 14 omega 57.00 105.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 -30.0000 48 #__ type_ start__ end____ width___ exp.time_ 15 omega 50.00 76.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 120.0000 26 #__ type_ start__ end____ width___ exp.time_ 16 omega 124.00 157.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 111.0000 -180.0000 33 #__ type_ start__ end____ width___ exp.time_ 17 omega 45.00 92.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 60.0000 47 #__ type_ start__ end____ width___ exp.time_ 18 omega 58.00 91.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 -180.0000 33 #__ type_ start__ end____ width___ exp.time_ 19 omega 44.00 89.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 150.0000 45 #__ type_ start__ end____ width___ exp.time_ 20 omega 44.00 98.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 -120.0000 54 #__ type_ start__ end____ width___ exp.time_ 21 omega 38.00 98.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 -60.0000 60 #__ type_ start__ end____ width___ exp.time_ 22 omega 111.00 169.00 1.0000 7.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 61.0000 -90.0000 58 ; _diffrn_measurement_device 'four-circle diffractometer' _diffrn_measurement_device_type 'Xcalibur, Eos, Gemini' _diffrn_measurement_method '\w scans' _diffrn_orient_matrix_UB_11 0.1391169000 _diffrn_orient_matrix_UB_12 -0.0170584000 _diffrn_orient_matrix_UB_13 -0.0208177000 _diffrn_orient_matrix_UB_21 0.0501147000 _diffrn_orient_matrix_UB_22 -0.0040021000 _diffrn_orient_matrix_UB_23 0.0788750000 _diffrn_orient_matrix_UB_31 -0.0326649000 _diffrn_orient_matrix_UB_32 -0.0785198000 _diffrn_orient_matrix_UB_33 0.0005240000 _diffrn_radiation_monochromator graphite _diffrn_radiation_probe x-ray _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54184 _diffrn_source 'Enhance (Cu) X-ray Source' _reflns_Friedel_coverage 0.000 _reflns_Friedel_fraction_full . _reflns_Friedel_fraction_max . _reflns_number_gt 5036 _reflns_number_total 6586 _reflns_odcompleteness_completeness 99.94 _reflns_odcompleteness_iscentric 1 _reflns_odcompleteness_theta 66.97 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_collection ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_reduction ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution ; Superflip (Palatinus & Chapuis, 2007;Palatinus & van der Lee, 2008; Palatinus et al., 2012) ; _refine_diff_density_max 1.014 _refine_diff_density_min -0.541 _refine_diff_density_rms 0.077 _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.044 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 473 _refine_ls_number_reflns 6586 _refine_ls_number_restraints 72 _refine_ls_R_factor_all 0.0870 _refine_ls_R_factor_gt 0.0701 _refine_ls_restrained_S_all 1.048 _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.1123P)^2^+2.5906P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1909 _refine_ls_wR_factor_ref 0.2129 _refine_special_details ? _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups At 1.5 times of: All C(H,H,H) groups 2. Uiso/Uaniso restraints and constraints Uanis(C45A) \\sim Ueq, Uanis(C44A) \\sim Ueq, Uanis(C44) \\sim Ueq, Uanis(C45) \\sim Ueq, Uanis(C46) \\sim Ueq, Uanis(C43) \\sim Ueq, Uanis(C43A) \\sim Ueq, Uanis(C42A) \\sim Ueq, Uanis(C42) \\sim Ueq, Uanis(C41A) \\sim Ueq, Uanis(C41) \\sim Ueq, Uanis(C46A) \\sim Ueq: with sigma of 0.01 and sigma for terminal atoms of 0.02 Uanis(C40) = Uanis(C40A) Uanis(C41) = Uanis(C41A) Uanis(C46) = Uanis(C46A) Uanis(C45) = Uanis(C45A) Uanis(C44) = Uanis(C44A) Uanis(C43) = Uanis(C43A) Uanis(C42) = Uanis(C42A) 3. Others Sof(C40A)=Sof(H40C)=Sof(H40D)=1-FVAR(1) Sof(C40)=Sof(H40A)=Sof(H40B)=FVAR(1) Sof(C41A)=Sof(C42A)=Sof(H42A)=Sof(C43A)=Sof(H43A)=Sof(C44A)=Sof(H44A)= Sof(C45A)=Sof(H45A)=Sof(C46A)=Sof(H46A)=1-FVAR(2) Sof(C41)=Sof(C42)=Sof(H42)=Sof(C43)=Sof(H43)=Sof(C44)=Sof(H44)=Sof(C45)= Sof(H45)=Sof(C46)=Sof(H46)=FVAR(2) 4.a Ternary CH refined with riding coordinates: C15(H15), C22(H22), C23(H23), C31(H31) 4.b Secondary CH2 refined with riding coordinates: C10(H10A,H10B), C12(H12A,H12B), C24(H24A,H24B), C40(H40A,H40B), C40A(H40C,H40D) 4.c Aromatic/amide H refined with riding coordinates: C1(H1), C2(H2), C4(H4), C5(H5), C17(H17), C18(H18), C19(H19), C20(H20), C26(H26), C27(H27), C28(H28), C29(H29), C30(H30), C33(H33), C34(H34), C35(H35), C36(H36), C38(H38), C39(H39), C42A(H42A), C43A(H43A), C44A(H44A), C45A(H45A), C46A(H46A), C42(H42), C43(H43), C44(H44), C45(H45), C46(H46) 4.d Fitted hexagon refined as free rotating group: C41A(C42A,C43A,C44A,C45A,C46A) 4.e Idealised Me refined as rotating group: C13(H13A,H13B,H13C), C14(H14A,H14B,H14C) ; _atom_sites_solution_hydrogens geom _atom_sites_solution_primary iterative _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group Br1 Br -0.36009(6) 0.90671(4) 0.70401(3) 0.0917(3) Uani 1 1 d . . . . . C1 C -0.2227(3) 0.81395(19) 0.5282(2) 0.0452(8) Uani 1 1 d . . . . . H1 H -0.2328 0.7709 0.5057 0.054 Uiso 1 1 calc R . . . . C2 C -0.2848(4) 0.8266(2) 0.5890(2) 0.0533(9) Uani 1 1 d . . . . . H2 H -0.3349 0.7919 0.6081 0.064 Uiso 1 1 calc R . . . . C3 C -0.2721(4) 0.8904(2) 0.62096(19) 0.0513(9) Uani 1 1 d . . . . . C4 C -0.1988(4) 0.9419(2) 0.5952(2) 0.0558(10) Uani 1 1 d . . . . . H4 H -0.1922 0.9853 0.6171 0.067 Uiso 1 1 calc R . . . . C5 C -0.1336(4) 0.9283(2) 0.5353(2) 0.0482(8) Uani 1 1 d . . . . . H5 H -0.0805 0.9627 0.5180 0.058 Uiso 1 1 calc R . . . . C6 C -0.1458(3) 0.86489(17) 0.50060(16) 0.0355(7) Uani 1 1 d . . . . . C7 C -0.0690(3) 0.89101(18) 0.38386(18) 0.0403(7) Uani 1 1 d . . . . . C8 C 0.0219(3) 0.87891(18) 0.33594(19) 0.0412(7) Uani 1 1 d . . . . . C9 C 0.0198(4) 0.9169(2) 0.2705(2) 0.0639(12) Uani 1 1 d . . . . . C10 C -0.0760(5) 0.9780(2) 0.2602(2) 0.0648(11) Uani 1 1 d . . . . . H10A H -0.0329 1.0199 0.2791 0.078 Uiso 1 1 calc R . . . . H10B H -0.0974 0.9851 0.2099 0.078 Uiso 1 1 calc R . . . . C11 C -0.2014(3) 0.96785(18) 0.29516(18) 0.0422(7) Uani 1 1 d . . . . . C12 C -0.1704(4) 0.9491(2) 0.3736(2) 0.0536(9) Uani 1 1 d . . . . . H12A H -0.1376 0.9903 0.3992 0.064 Uiso 1 1 calc R . . . . H12B H -0.2506 0.9346 0.3934 0.064 Uiso 1 1 calc R . . . . C13 C -0.2833(5) 0.9083(3) 0.2594(3) 0.0747(14) Uani 1 1 d . . . . . H13A H -0.3627 0.9025 0.2826 0.112 Uiso 1 1 calc GR . . . . H13B H -0.2334 0.8658 0.2629 0.112 Uiso 1 1 calc GR . . . . H13C H -0.3051 0.9195 0.2105 0.112 Uiso 1 1 calc GR . . . . C14 C -0.2870(5) 1.0325(3) 0.2904(3) 0.0763(15) Uani 1 1 d . . . . . H14A H -0.3675 1.0232 0.3115 0.115 Uiso 1 1 calc GR . . . . H14B H -0.3063 1.0450 0.2416 0.115 Uiso 1 1 calc GR . . . . H14C H -0.2415 1.0702 0.3151 0.115 Uiso 1 1 calc GR . . . . C15 C 0.1226(3) 0.82176(17) 0.35197(16) 0.0351(7) Uani 1 1 d . . . . . H15 H 0.1559 0.8059 0.3077 0.042 Uiso 1 1 calc R . . . . C16 C 0.2354(3) 0.84907(16) 0.40059(17) 0.0359(7) Uani 1 1 d . . . . . C17 C 0.3363(4) 0.88669(19) 0.3727(2) 0.0475(8) Uani 1 1 d . . . . . H17 H 0.3375 0.8911 0.3239 0.057 Uiso 1 1 calc R . . . . C18 C 0.4345(4) 0.9175(2) 0.4168(3) 0.0569(10) Uani 1 1 d . . . . . H18 H 0.5016 0.9419 0.3975 0.068 Uiso 1 1 calc R . . . . C19 C 0.4332(4) 0.9122(2) 0.4892(3) 0.0579(11) Uani 1 1 d . . . . . H19 H 0.4985 0.9335 0.5188 0.069 Uiso 1 1 calc R . . . . C20 C 0.3335(4) 0.87467(18) 0.5176(2) 0.0479(8) Uani 1 1 d . . . . . H20 H 0.3324 0.8716 0.5665 0.057 Uiso 1 1 calc R . . . . C21 C 0.2354(3) 0.84162(16) 0.47442(17) 0.0371(7) Uani 1 1 d . . . . . C22 C 0.1308(3) 0.79904(15) 0.50634(15) 0.0321(6) Uani 1 1 d . . . . . H22 H 0.0986 0.8265 0.5450 0.038 Uiso 1 1 calc R . . . . C23 C 0.0144(3) 0.78617(15) 0.45175(15) 0.0310(6) Uani 1 1 d . . . . . H23 H -0.0385 0.7485 0.4698 0.037 Uiso 1 1 calc R . . . . C24 C -0.0418(4) 0.72883(19) 0.33945(18) 0.0435(8) Uani 1 1 d . . . . . H24A H -0.0115 0.7238 0.2926 0.052 Uiso 1 1 calc R . . . . H24B H -0.1194 0.7583 0.3355 0.052 Uiso 1 1 calc R . . . . C25 C -0.0773(3) 0.65819(18) 0.36675(17) 0.0400(7) Uani 1 1 d . . . . . C26 C 0.0186(4) 0.60650(19) 0.37624(19) 0.0456(8) Uani 1 1 d . . . . . H26 H 0.1041 0.6158 0.3654 0.055 Uiso 1 1 calc R . . . . C27 C -0.0125(5) 0.5415(2) 0.4016(2) 0.0588(10) Uani 1 1 d . . . . . H27 H 0.0521 0.5072 0.4075 0.071 Uiso 1 1 calc R . . . . C28 C -0.1377(5) 0.5271(2) 0.4183(2) 0.0653(12) Uani 1 1 d . . . . . H28 H -0.1581 0.4832 0.4353 0.078 Uiso 1 1 calc R . . . . C29 C -0.2331(4) 0.5778(3) 0.4101(2) 0.0655(12) Uani 1 1 d . . . . . H29 H -0.3179 0.5682 0.4219 0.079 Uiso 1 1 calc R . . . . C30 C -0.2032(4) 0.6433(2) 0.3841(2) 0.0519(9) Uani 1 1 d . . . . . H30 H -0.2683 0.6772 0.3783 0.062 Uiso 1 1 calc R . . . . C31 C 0.1754(3) 0.72555(16) 0.53763(16) 0.0343(6) Uani 1 1 d . . . . . H31 H 0.1763 0.6922 0.4985 0.041 Uiso 1 1 calc R . . . . C32 C 0.0745(3) 0.70161(17) 0.58682(17) 0.0404(7) Uani 1 1 d . . . . . C33 C -0.0290(4) 0.65703(18) 0.5660(2) 0.0477(8) Uani 1 1 d . . . . . H33 H -0.0321 0.6354 0.5219 0.057 Uiso 1 1 calc R . . . . C34 C -0.1281(5) 0.6444(2) 0.6104(3) 0.0667(12) Uani 1 1 d . . . . . H34 H -0.1976 0.6150 0.5958 0.080 Uiso 1 1 calc R . . . . C35 C -0.1231(5) 0.6753(3) 0.6754(3) 0.0771(15) Uani 1 1 d . . . . . H35 H -0.1906 0.6678 0.7046 0.092 Uiso 1 1 calc R . . . . C36 C -0.0178(6) 0.7181(3) 0.6985(2) 0.0741(14) Uani 1 1 d . . . . . H36 H -0.0153 0.7386 0.7431 0.089 Uiso 1 1 calc R . . . . C37 C 0.0843(4) 0.7305(2) 0.65525(19) 0.0528(9) Uani 1 1 d . . . . . C38 C 0.2066(5) 0.7647(2) 0.6789(2) 0.0630(11) Uani 1 1 d . . . . . H38 H 0.2118 0.7926 0.7191 0.076 Uiso 1 1 calc R . . . . C39 C 0.3126(4) 0.7558(2) 0.6423(2) 0.0574(10) Uani 1 1 d . . . . . H39 H 0.3941 0.7705 0.6624 0.069 Uiso 1 1 calc R . . . . C40 C 0.4262(5) 0.7119(3) 0.5409(4) 0.0616(15) Uani 0.773(8) 1 d . . P A 1 H40A H 0.4945 0.6965 0.5761 0.074 Uiso 0.773(8) 1 calc R . P A 1 H40B H 0.4554 0.7552 0.5208 0.074 Uiso 0.773(8) 1 calc R . P A 1 C40A C 0.3876(17) 0.6662(10) 0.5679(12) 0.0616(15) Uani 0.227(8) 1 d . . P A 2 H40C H 0.3477 0.6255 0.5878 0.074 Uiso 0.227(8) 1 calc R . P A 2 H40D H 0.4719 0.6739 0.5944 0.074 Uiso 0.227(8) 1 calc R . P A 2 C41 C 0.4103(7) 0.6582(4) 0.4835(4) 0.0518(11) Uani 0.793(7) 1 d . U P A 1 C41A C 0.410(2) 0.6517(11) 0.4928(8) 0.0518(11) Uani 0.207(7) 1 d . U P A 2 C42A C 0.380(2) 0.5872(9) 0.4619(12) 0.0610(15) Uani 0.207(7) 1 d G U P A 2 H42A H 0.3524 0.5506 0.4893 0.073 Uiso 0.207(7) 1 calc R . P A 2 C43A C 0.391(2) 0.5774(9) 0.3900(12) 0.0703(17) Uani 0.207(7) 1 d G U P A 2 H43A H 0.3715 0.5343 0.3693 0.084 Uiso 0.207(7) 1 calc R . P A 2 C44A C 0.433(2) 0.6322(12) 0.3490(9) 0.0774(18) Uani 0.207(7) 1 d G U P A 2 H44A H 0.4403 0.6256 0.3009 0.093 Uiso 0.207(7) 1 calc R . P A 2 C45A C 0.4623(18) 0.6967(9) 0.3800(9) 0.082(2) Uani 0.207(7) 1 d G U P A 2 H45A H 0.4899 0.7333 0.3525 0.098 Uiso 0.207(7) 1 calc R . P A 2 C46A C 0.4509(19) 0.7064(8) 0.4519(10) 0.0700(17) Uani 0.207(7) 1 d G U P A 2 H46A H 0.4708 0.7496 0.4726 0.084 Uiso 0.207(7) 1 calc R . P A 2 C42 C 0.3903(6) 0.5886(3) 0.5000(4) 0.0610(15) Uani 0.793(7) 1 d . U P A 1 H42 H 0.3877 0.5749 0.5470 0.073 Uiso 0.793(7) 1 calc R . P A 1 C43 C 0.3741(6) 0.5399(3) 0.4459(4) 0.0703(17) Uani 0.793(7) 1 d . U P A 1 H43 H 0.3596 0.4934 0.4574 0.084 Uiso 0.793(7) 1 calc R . P A 1 C44 C 0.3788(7) 0.5575(4) 0.3767(4) 0.0774(18) Uani 0.793(7) 1 d . U P A 1 H44 H 0.3681 0.5238 0.3414 0.093 Uiso 0.793(7) 1 calc R . P A 1 C45 C 0.3995(7) 0.6255(5) 0.3604(4) 0.082(2) Uani 0.793(7) 1 d . U P A 1 H45 H 0.4034 0.6383 0.3133 0.098 Uiso 0.793(7) 1 calc R . P A 1 C46 C 0.4150(6) 0.6765(3) 0.4133(4) 0.0700(17) Uani 0.793(7) 1 d . U P A 1 H46 H 0.4285 0.7228 0.4011 0.084 Uiso 0.793(7) 1 calc R . P A 1 N1 N -0.0722(3) 0.84935(14) 0.44203(14) 0.0365(6) Uani 1 1 d . . . . . N2 N 0.0611(2) 0.76250(13) 0.38629(13) 0.0329(5) Uani 1 1 d . . . . . N3 N 0.3051(3) 0.72575(16) 0.57641(16) 0.0450(7) Uani 1 1 d . . . . . O1 O 0.0948(4) 0.9028(2) 0.22473(19) 0.0924(14) Uani 1 1 d . . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 Br1 0.0830(4) 0.1458(6) 0.0506(3) 0.0005(3) 0.0310(3) 0.0306(4) C1 0.0403(17) 0.0482(19) 0.049(2) 0.0044(16) 0.0164(15) -0.0019(15) C2 0.048(2) 0.064(2) 0.051(2) 0.0167(18) 0.0199(17) 0.0016(18) C3 0.0405(18) 0.081(3) 0.0336(17) 0.0030(17) 0.0100(14) 0.0158(18) C4 0.052(2) 0.061(2) 0.054(2) -0.0123(19) 0.0091(18) 0.0063(18) C5 0.0427(18) 0.0479(19) 0.056(2) 0.0026(17) 0.0138(16) -0.0018(15) C6 0.0300(14) 0.0460(17) 0.0312(15) 0.0059(13) 0.0069(12) 0.0049(13) C7 0.0377(16) 0.0459(17) 0.0383(17) 0.0121(14) 0.0086(14) 0.0068(14) C8 0.0367(16) 0.0485(18) 0.0393(17) 0.0138(14) 0.0083(14) 0.0074(14) C9 0.056(2) 0.084(3) 0.056(2) 0.034(2) 0.025(2) 0.023(2) C10 0.071(3) 0.069(3) 0.055(2) 0.022(2) 0.009(2) 0.010(2) C11 0.0421(17) 0.0451(18) 0.0389(17) 0.0065(14) -0.0008(14) 0.0092(15) C12 0.052(2) 0.059(2) 0.050(2) 0.0152(18) 0.0110(17) 0.0158(18) C13 0.072(3) 0.082(3) 0.068(3) -0.002(2) -0.014(2) 0.002(2) C14 0.086(3) 0.081(3) 0.064(3) 0.031(2) 0.017(2) 0.038(3) C15 0.0345(15) 0.0427(16) 0.0293(15) 0.0035(12) 0.0092(12) 0.0047(13) C16 0.0351(15) 0.0342(15) 0.0394(16) 0.0031(13) 0.0084(13) 0.0043(12) C17 0.0409(18) 0.0505(19) 0.053(2) 0.0070(16) 0.0162(16) 0.0026(15) C18 0.0417(19) 0.051(2) 0.079(3) 0.0101(19) 0.0113(19) -0.0088(16) C19 0.045(2) 0.050(2) 0.076(3) 0.0041(19) -0.012(2) -0.0112(17) C20 0.051(2) 0.0413(18) 0.049(2) 0.0037(15) -0.0082(16) -0.0044(15) C21 0.0405(17) 0.0334(15) 0.0375(16) 0.0019(13) 0.0037(13) 0.0014(13) C22 0.0358(15) 0.0346(15) 0.0259(14) 0.0004(12) 0.0029(12) 0.0008(12) C23 0.0311(14) 0.0343(14) 0.0277(14) 0.0059(11) 0.0042(11) 0.0034(12) C24 0.0486(19) 0.0499(19) 0.0306(15) 0.0007(14) -0.0048(14) -0.0024(15) C25 0.0431(17) 0.0468(18) 0.0290(15) -0.0062(13) -0.0025(13) -0.0060(14) C26 0.0418(18) 0.054(2) 0.0412(18) -0.0076(15) 0.0038(15) -0.0021(15) C27 0.068(3) 0.046(2) 0.061(2) -0.0016(18) -0.002(2) 0.0001(19) C28 0.077(3) 0.056(2) 0.061(3) 0.006(2) -0.006(2) -0.025(2) C29 0.053(2) 0.086(3) 0.057(3) 0.005(2) 0.0027(19) -0.028(2) C30 0.0403(18) 0.068(2) 0.046(2) -0.0028(18) -0.0027(15) -0.0065(17) C31 0.0361(15) 0.0357(15) 0.0302(15) -0.0005(12) -0.0026(12) 0.0014(12) C32 0.0475(18) 0.0404(16) 0.0334(16) 0.0100(13) 0.0034(14) 0.0061(14) C33 0.052(2) 0.0425(18) 0.049(2) 0.0111(15) 0.0041(16) -0.0017(15) C34 0.061(3) 0.064(2) 0.076(3) 0.027(2) 0.013(2) -0.007(2) C35 0.074(3) 0.094(4) 0.066(3) 0.037(3) 0.028(3) 0.007(3) C36 0.099(4) 0.087(3) 0.039(2) 0.016(2) 0.018(2) 0.017(3) C37 0.072(3) 0.055(2) 0.0318(17) 0.0063(15) 0.0064(17) 0.0080(19) C38 0.097(3) 0.060(2) 0.0298(17) -0.0039(16) -0.007(2) 0.003(2) C39 0.068(3) 0.057(2) 0.043(2) 0.0055(17) -0.0255(19) -0.0060(19) C40 0.038(2) 0.051(3) 0.095(4) -0.002(3) -0.002(2) 0.000(2) C40A 0.038(2) 0.051(3) 0.095(4) -0.002(3) -0.002(2) 0.000(2) C41 0.0323(16) 0.051(2) 0.073(3) 0.004(2) 0.0082(19) 0.0088(16) C41A 0.0323(16) 0.051(2) 0.073(3) 0.004(2) 0.0082(19) 0.0088(16) C42A 0.057(3) 0.053(2) 0.073(4) 0.000(3) 0.012(3) 0.001(2) C43A 0.059(3) 0.059(3) 0.095(4) -0.012(3) 0.015(3) 0.001(2) C44A 0.058(3) 0.087(4) 0.088(4) -0.027(3) 0.010(3) 0.006(3) C45A 0.062(4) 0.113(5) 0.071(4) 0.005(4) 0.017(3) 0.014(3) C46A 0.054(3) 0.071(3) 0.086(4) 0.016(3) 0.015(3) 0.006(3) C42 0.057(3) 0.053(2) 0.073(4) 0.000(3) 0.012(3) 0.001(2) C43 0.059(3) 0.059(3) 0.095(4) -0.012(3) 0.015(3) 0.001(2) C44 0.058(3) 0.087(4) 0.088(4) -0.027(3) 0.010(3) 0.006(3) C45 0.062(4) 0.113(5) 0.071(4) 0.005(4) 0.017(3) 0.014(3) C46 0.054(3) 0.071(3) 0.086(4) 0.016(3) 0.015(3) 0.006(3) N1 0.0346(13) 0.0416(14) 0.0347(14) 0.0092(11) 0.0106(11) 0.0069(11) N2 0.0342(13) 0.0386(13) 0.0258(12) 0.0014(10) 0.0021(10) 0.0008(10) N3 0.0425(15) 0.0489(16) 0.0416(15) 0.0022(13) -0.0084(12) 0.0019(13) O1 0.089(2) 0.130(3) 0.065(2) 0.056(2) 0.0492(19) 0.055(2) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag Br1 C3 1.902(4) . ? C1 H1 0.9300 . ? C1 C2 1.383(5) . ? C1 C6 1.382(5) . ? C2 H2 0.9300 . ? C2 C3 1.364(6) . ? C3 C4 1.354(6) . ? C4 H4 0.9300 . ? C4 C5 1.388(5) . ? C5 H5 0.9300 . ? C5 C6 1.382(5) . ? C6 N1 1.423(4) . ? C7 C8 1.372(5) . ? C7 C12 1.521(5) . ? C7 N1 1.363(4) . ? C8 C9 1.436(5) . ? C8 C15 1.515(4) . ? C9 C10 1.527(6) . ? C9 O1 1.234(5) . ? C10 H10A 0.9700 . ? C10 H10B 0.9700 . ? C10 C11 1.502(6) . ? C11 C12 1.537(5) . ? C11 C13 1.537(6) . ? C11 C14 1.513(5) . ? C12 H12A 0.9700 . ? C12 H12B 0.9700 . ? C13 H13A 0.9600 . ? C13 H13B 0.9600 . ? C13 H13C 0.9600 . ? C14 H14A 0.9600 . ? C14 H14B 0.9600 . ? C14 H14C 0.9600 . ? C15 H15 0.9800 . ? C15 C16 1.507(5) . ? C15 N2 1.474(4) . ? C16 C17 1.396(5) . ? C16 C21 1.406(5) . ? C17 H17 0.9300 . ? C17 C18 1.382(6) . ? C18 H18 0.9300 . ? C18 C19 1.376(7) . ? C19 H19 0.9300 . ? C19 C20 1.391(6) . ? C20 H20 0.9300 . ? C20 C21 1.391(5) . ? C21 C22 1.510(4) . ? C22 H22 0.9800 . ? C22 C23 1.529(4) . ? C22 C31 1.580(4) . ? C23 H23 0.9800 . ? C23 N1 1.501(4) . ? C23 N2 1.439(4) . ? C24 H24A 0.9700 . ? C24 H24B 0.9700 . ? C24 C25 1.504(5) . ? C24 N2 1.467(4) . ? C25 C26 1.394(5) . ? C25 C30 1.383(5) . ? C26 H26 0.9300 . ? C26 C27 1.381(6) . ? C27 H27 0.9300 . ? C27 C28 1.371(7) . ? C28 H28 0.9300 . ? C28 C29 1.374(7) . ? C29 H29 0.9300 . ? C29 C30 1.391(6) . ? C30 H30 0.9300 . ? C31 H31 0.9800 . ? C31 C32 1.517(5) . ? C31 N3 1.459(4) . ? C32 C33 1.390(5) . ? C32 C37 1.406(5) . ? C33 H33 0.9300 . ? C33 C34 1.390(6) . ? C34 H34 0.9300 . ? C34 C35 1.364(8) . ? C35 H35 0.9300 . ? C35 C36 1.392(8) . ? C36 H36 0.9300 . ? C36 C37 1.399(6) . ? C37 C38 1.446(7) . ? C38 H38 0.9300 . ? C38 C39 1.344(7) . ? C39 H39 0.9300 . ? C39 N3 1.371(5) . ? C40 H40A 0.9700 . ? C40 H40B 0.9700 . ? C40 C41 1.496(9) . ? C40 N3 1.481(6) . ? C40A H40C 0.9700 . ? C40A H40D 0.9700 . ? C40A C41A 1.49(3) . ? C40A N3 1.436(18) . ? C41 C42 1.387(8) . ? C41 C46 1.380(10) . ? C41A C42A 1.3900 . ? C41A C46A 1.3900 . ? C42A H42A 0.9300 . ? C42A C43A 1.3900 . ? C43A H43A 0.9300 . ? C43A C44A 1.3900 . ? C44A H44A 0.9300 . ? C44A C45A 1.3900 . ? C45A H45A 0.9300 . ? C45A C46A 1.3900 . ? C46A H46A 0.9300 . ? C42 H42 0.9300 . ? C42 C43 1.387(9) . ? C43 H43 0.9300 . ? C43 C44 1.359(11) . ? C44 H44 0.9300 . ? C44 C45 1.359(11) . ? C45 H45 0.9300 . ? C45 C46 1.400(11) . ? C46 H46 0.9300 . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C2 C1 H1 119.8 . . ? C6 C1 H1 119.8 . . ? C6 C1 C2 120.4(4) . . ? C1 C2 H2 120.2 . . ? C3 C2 C1 119.6(4) . . ? C3 C2 H2 120.2 . . ? C2 C3 Br1 118.7(3) . . ? C4 C3 Br1 119.5(3) . . ? C4 C3 C2 121.8(3) . . ? C3 C4 H4 120.8 . . ? C3 C4 C5 118.4(4) . . ? C5 C4 H4 120.8 . . ? C4 C5 H5 119.2 . . ? C6 C5 C4 121.6(3) . . ? C6 C5 H5 119.2 . . ? C1 C6 N1 120.1(3) . . ? C5 C6 C1 118.2(3) . . ? C5 C6 N1 121.5(3) . . ? C8 C7 C12 122.0(3) . . ? N1 C7 C8 120.0(3) . . ? N1 C7 C12 118.0(3) . . ? C7 C8 C9 121.6(3) . . ? C7 C8 C15 118.4(3) . . ? C9 C8 C15 120.0(3) . . ? C8 C9 C10 117.4(3) . . ? O1 C9 C8 122.1(4) . . ? O1 C9 C10 120.5(4) . . ? C9 C10 H10A 108.8 . . ? C9 C10 H10B 108.8 . . ? H10A C10 H10B 107.7 . . ? C11 C10 C9 113.9(3) . . ? C11 C10 H10A 108.8 . . ? C11 C10 H10B 108.8 . . ? C10 C11 C12 110.0(3) . . ? C10 C11 C13 110.7(4) . . ? C10 C11 C14 112.1(3) . . ? C12 C11 C13 108.3(3) . . ? C14 C11 C12 108.7(3) . . ? C14 C11 C13 106.9(4) . . ? C7 C12 C11 112.2(3) . . ? C7 C12 H12A 109.2 . . ? C7 C12 H12B 109.2 . . ? C11 C12 H12A 109.2 . . ? C11 C12 H12B 109.2 . . ? H12A C12 H12B 107.9 . . ? C11 C13 H13A 109.5 . . ? C11 C13 H13B 109.5 . . ? C11 C13 H13C 109.5 . . ? H13A C13 H13B 109.5 . . ? H13A C13 H13C 109.5 . . ? H13B C13 H13C 109.5 . . ? C11 C14 H14A 109.5 . . ? C11 C14 H14B 109.5 . . ? C11 C14 H14C 109.5 . . ? H14A C14 H14B 109.5 . . ? H14A C14 H14C 109.5 . . ? H14B C14 H14C 109.5 . . ? C8 C15 H15 109.3 . . ? C16 C15 C8 110.0(3) . . ? C16 C15 H15 109.3 . . ? N2 C15 C8 109.7(3) . . ? N2 C15 H15 109.3 . . ? N2 C15 C16 109.2(2) . . ? C17 C16 C15 119.9(3) . . ? C17 C16 C21 119.4(3) . . ? C21 C16 C15 120.6(3) . . ? C16 C17 H17 119.6 . . ? C18 C17 C16 120.8(4) . . ? C18 C17 H17 119.6 . . ? C17 C18 H18 119.9 . . ? C19 C18 C17 120.3(4) . . ? C19 C18 H18 119.9 . . ? C18 C19 H19 120.3 . . ? C18 C19 C20 119.5(4) . . ? C20 C19 H19 120.3 . . ? C19 C20 H20 119.3 . . ? C19 C20 C21 121.4(4) . . ? C21 C20 H20 119.3 . . ? C16 C21 C22 120.8(3) . . ? C20 C21 C16 118.6(3) . . ? C20 C21 C22 120.6(3) . . ? C21 C22 H22 107.6 . . ? C21 C22 C23 110.6(2) . . ? C21 C22 C31 116.1(3) . . ? C23 C22 H22 107.6 . . ? C23 C22 C31 107.1(2) . . ? C31 C22 H22 107.6 . . ? C22 C23 H23 107.5 . . ? N1 C23 C22 111.7(2) . . ? N1 C23 H23 107.5 . . ? N2 C23 C22 109.8(2) . . ? N2 C23 H23 107.5 . . ? N2 C23 N1 112.5(2) . . ? H24A C24 H24B 108.0 . . ? C25 C24 H24A 109.3 . . ? C25 C24 H24B 109.3 . . ? N2 C24 H24A 109.3 . . ? N2 C24 H24B 109.3 . . ? N2 C24 C25 111.6(3) . . ? C26 C25 C24 119.8(3) . . ? C30 C25 C24 121.5(3) . . ? C30 C25 C26 118.7(3) . . ? C25 C26 H26 119.8 . . ? C27 C26 C25 120.4(4) . . ? C27 C26 H26 119.8 . . ? C26 C27 H27 119.8 . . ? C28 C27 C26 120.5(4) . . ? C28 C27 H27 119.8 . . ? C27 C28 H28 120.1 . . ? C27 C28 C29 119.9(4) . . ? C29 C28 H28 120.1 . . ? C28 C29 H29 119.9 . . ? C28 C29 C30 120.2(4) . . ? C30 C29 H29 119.9 . . ? C25 C30 C29 120.4(4) . . ? C25 C30 H30 119.8 . . ? C29 C30 H30 119.8 . . ? C22 C31 H31 108.5 . . ? C32 C31 C22 108.1(2) . . ? C32 C31 H31 108.5 . . ? N3 C31 C22 114.1(3) . . ? N3 C31 H31 108.5 . . ? N3 C31 C32 109.0(3) . . ? C33 C32 C31 123.4(3) . . ? C33 C32 C37 119.9(3) . . ? C37 C32 C31 116.6(3) . . ? C32 C33 H33 119.7 . . ? C32 C33 C34 120.5(4) . . ? C34 C33 H33 119.7 . . ? C33 C34 H34 120.1 . . ? C35 C34 C33 119.9(5) . . ? C35 C34 H34 120.1 . . ? C34 C35 H35 119.7 . . ? C34 C35 C36 120.5(4) . . ? C36 C35 H35 119.7 . . ? C35 C36 H36 119.7 . . ? C35 C36 C37 120.7(4) . . ? C37 C36 H36 119.7 . . ? C32 C37 C38 117.2(4) . . ? C36 C37 C32 118.3(4) . . ? C36 C37 C38 124.1(4) . . ? C37 C38 H38 120.2 . . ? C39 C38 C37 119.6(4) . . ? C39 C38 H38 120.2 . . ? C38 C39 H39 118.7 . . ? C38 C39 N3 122.5(4) . . ? N3 C39 H39 118.7 . . ? H40A C40 H40B 107.6 . . ? C41 C40 H40A 108.7 . . ? C41 C40 H40B 108.7 . . ? N3 C40 H40A 108.7 . . ? N3 C40 H40B 108.7 . . ? N3 C40 C41 114.2(5) . . ? H40C C40A H40D 107.8 . . ? C41A C40A H40C 108.9 . . ? C41A C40A H40D 108.9 . . ? N3 C40A H40C 108.9 . . ? N3 C40A H40D 108.9 . . ? N3 C40A C41A 113.2(17) . . ? C42 C41 C40 120.3(7) . . ? C46 C41 C40 121.0(6) . . ? C46 C41 C42 118.6(7) . . ? C42A C41A C40A 121.6(14) . . ? C42A C41A C46A 120.0 . . ? C46A C41A C40A 118.1(14) . . ? C41A C42A H42A 120.0 . . ? C43A C42A C41A 120.0 . . ? C43A C42A H42A 120.0 . . ? C42A C43A H43A 120.0 . . ? C42A C43A C44A 120.0 . . ? C44A C43A H43A 120.0 . . ? C43A C44A H44A 120.0 . . ? C45A C44A C43A 120.0 . . ? C45A C44A H44A 120.0 . . ? C44A C45A H45A 120.0 . . ? C46A C45A C44A 120.0 . . ? C46A C45A H45A 120.0 . . ? C41A C46A H46A 120.0 . . ? C45A C46A C41A 120.0 . . ? C45A C46A H46A 120.0 . . ? C41 C42 H42 120.3 . . ? C43 C42 C41 119.3(7) . . ? C43 C42 H42 120.3 . . ? C42 C43 H43 118.8 . . ? C44 C43 C42 122.3(6) . . ? C44 C43 H43 118.8 . . ? C43 C44 H44 120.8 . . ? C43 C44 C45 118.5(7) . . ? C45 C44 H44 120.8 . . ? C44 C45 H45 119.5 . . ? C44 C45 C46 121.0(7) . . ? C46 C45 H45 119.5 . . ? C41 C46 C45 120.2(6) . . ? C41 C46 H46 119.9 . . ? C45 C46 H46 119.9 . . ? C6 N1 C23 114.6(2) . . ? C7 N1 C6 123.9(3) . . ? C7 N1 C23 121.2(3) . . ? C23 N2 C15 108.8(2) . . ? C23 N2 C24 112.8(3) . . ? C24 N2 C15 112.4(2) . . ? C31 N3 C40 121.8(3) . . ? C39 N3 C31 116.0(3) . . ? C39 N3 C40 120.3(4) . . ? C39 N3 C40A 116.6(9) . . ? C40A N3 C31 117.2(8) . . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag Br1 C3 C4 C5 178.9(3) . . . . ? C1 C2 C3 Br1 179.3(3) . . . . ? C1 C2 C3 C4 -0.8(6) . . . . ? C1 C6 N1 C7 133.2(4) . . . . ? C1 C6 N1 C23 -52.6(4) . . . . ? C2 C1 C6 C5 -0.3(5) . . . . ? C2 C1 C6 N1 174.0(3) . . . . ? C2 C3 C4 C5 -1.0(6) . . . . ? C3 C4 C5 C6 2.2(6) . . . . ? C4 C5 C6 C1 -1.6(6) . . . . ? C4 C5 C6 N1 -175.7(3) . . . . ? C5 C6 N1 C7 -52.7(5) . . . . ? C5 C6 N1 C23 121.4(3) . . . . ? C6 C1 C2 C3 1.4(6) . . . . ? C7 C8 C9 C10 7.8(7) . . . . ? C7 C8 C9 O1 -174.4(5) . . . . ? C7 C8 C15 C16 -83.0(4) . . . . ? C7 C8 C15 N2 37.3(4) . . . . ? C8 C7 C12 C11 26.1(5) . . . . ? C8 C7 N1 C6 168.3(3) . . . . ? C8 C7 N1 C23 -5.5(5) . . . . ? C8 C9 C10 C11 -32.9(6) . . . . ? C8 C15 C16 C17 -82.3(4) . . . . ? C8 C15 C16 C21 92.9(3) . . . . ? C8 C15 N2 C23 -61.0(3) . . . . ? C8 C15 N2 C24 64.7(3) . . . . ? C9 C8 C15 C16 99.6(4) . . . . ? C9 C8 C15 N2 -140.1(4) . . . . ? C9 C10 C11 C12 52.8(5) . . . . ? C9 C10 C11 C13 -66.8(5) . . . . ? C9 C10 C11 C14 173.9(4) . . . . ? C10 C11 C12 C7 -48.7(5) . . . . ? C12 C7 C8 C9 -5.1(6) . . . . ? C12 C7 C8 C15 177.6(3) . . . . ? C12 C7 N1 C6 -13.1(5) . . . . ? C12 C7 N1 C23 173.1(3) . . . . ? C13 C11 C12 C7 72.4(4) . . . . ? C14 C11 C12 C7 -171.8(4) . . . . ? C15 C8 C9 C10 -174.8(4) . . . . ? C15 C8 C9 O1 3.0(8) . . . . ? C15 C16 C17 C18 174.2(3) . . . . ? C15 C16 C21 C20 -172.6(3) . . . . ? C15 C16 C21 C22 7.1(4) . . . . ? C16 C15 N2 C23 59.7(3) . . . . ? C16 C15 N2 C24 -174.6(3) . . . . ? C16 C17 C18 C19 -0.8(6) . . . . ? C16 C21 C22 C23 -16.1(4) . . . . ? C16 C21 C22 C31 106.1(3) . . . . ? C17 C16 C21 C20 2.7(5) . . . . ? C17 C16 C21 C22 -177.7(3) . . . . ? C17 C18 C19 C20 1.0(6) . . . . ? C18 C19 C20 C21 0.7(6) . . . . ? C19 C20 C21 C16 -2.5(5) . . . . ? C19 C20 C21 C22 177.8(3) . . . . ? C20 C21 C22 C23 163.5(3) . . . . ? C20 C21 C22 C31 -74.2(4) . . . . ? C21 C16 C17 C18 -1.1(5) . . . . ? C21 C22 C23 N1 -77.7(3) . . . . ? C21 C22 C23 N2 47.8(3) . . . . ? C21 C22 C31 C32 162.1(3) . . . . ? C21 C22 C31 N3 40.7(4) . . . . ? C22 C23 N1 C6 -70.3(3) . . . . ? C22 C23 N1 C7 104.0(3) . . . . ? C22 C23 N2 C15 -72.3(3) . . . . ? C22 C23 N2 C24 162.2(2) . . . . ? C22 C31 C32 C33 95.9(4) . . . . ? C22 C31 C32 C37 -80.0(3) . . . . ? C22 C31 N3 C39 74.6(4) . . . . ? C22 C31 N3 C40 -90.0(4) . . . . ? C22 C31 N3 C40A -141.2(11) . . . . ? C23 C22 C31 C32 -73.8(3) . . . . ? C23 C22 C31 N3 164.8(3) . . . . ? C24 C25 C26 C27 179.6(3) . . . . ? C24 C25 C30 C29 -179.2(4) . . . . ? C25 C24 N2 C15 164.4(3) . . . . ? C25 C24 N2 C23 -72.2(4) . . . . ? C25 C26 C27 C28 -0.5(6) . . . . ? C26 C25 C30 C29 -0.3(5) . . . . ? C26 C27 C28 C29 -0.2(7) . . . . ? C27 C28 C29 C30 0.7(7) . . . . ? C28 C29 C30 C25 -0.4(6) . . . . ? C30 C25 C26 C27 0.8(5) . . . . ? C31 C22 C23 N1 154.9(2) . . . . ? C31 C22 C23 N2 -79.6(3) . . . . ? C31 C32 C33 C34 -171.3(3) . . . . ? C31 C32 C37 C36 170.5(3) . . . . ? C31 C32 C37 C38 -16.1(5) . . . . ? C32 C31 N3 C39 -46.3(4) . . . . ? C32 C31 N3 C40 149.1(4) . . . . ? C32 C31 N3 C40A 97.9(11) . . . . ? C32 C33 C34 C35 -0.8(6) . . . . ? C32 C37 C38 C39 -13.2(6) . . . . ? C33 C32 C37 C36 -5.5(5) . . . . ? C33 C32 C37 C38 167.8(3) . . . . ? C33 C34 C35 C36 -1.6(7) . . . . ? C34 C35 C36 C37 0.4(7) . . . . ? C35 C36 C37 C32 3.2(7) . . . . ? C35 C36 C37 C38 -169.7(4) . . . . ? C36 C37 C38 C39 159.7(4) . . . . ? C37 C32 C33 C34 4.4(5) . . . . ? C37 C38 C39 N3 11.9(6) . . . . ? C38 C39 N3 C31 20.2(5) . . . . ? C38 C39 N3 C40 -175.0(4) . . . . ? C38 C39 N3 C40A -124.2(10) . . . . ? C40 C41 C42 C43 179.2(6) . . . . ? C40 C41 C46 C45 -179.8(6) . . . . ? C40A C41A C42A C43A 175(2) . . . . ? C40A C41A C46A C45A -175(2) . . . . ? C41 C40 N3 C31 -36.5(6) . . . . ? C41 C40 N3 C39 159.6(5) . . . . ? C41 C42 C43 C44 0.8(10) . . . . ? C41A C40A N3 C31 55.8(17) . . . . ? C41A C40A N3 C39 -160.2(12) . . . . ? C41A C42A C43A C44A 0.0 . . . . ? C42A C41A C46A C45A 0.0 . . . . ? C42A C43A C44A C45A 0.0 . . . . ? C43A C44A C45A C46A 0.0 . . . . ? C44A C45A C46A C41A 0.0 . . . . ? C46A C41A C42A C43A 0.0 . . . . ? C42 C41 C46 C45 0.1(9) . . . . ? C42 C43 C44 C45 -0.3(11) . . . . ? C43 C44 C45 C46 -0.3(10) . . . . ? C44 C45 C46 C41 0.4(10) . . . . ? C46 C41 C42 C43 -0.7(9) . . . . ? N1 C7 C8 C9 173.5(4) . . . . ? N1 C7 C8 C15 -3.9(5) . . . . ? N1 C7 C12 C11 -152.4(3) . . . . ? N1 C23 N2 C15 52.7(3) . . . . ? N1 C23 N2 C24 -72.7(3) . . . . ? N2 C15 C16 C17 157.2(3) . . . . ? N2 C15 C16 C21 -27.6(4) . . . . ? N2 C23 N1 C6 165.7(3) . . . . ? N2 C23 N1 C7 -20.1(4) . . . . ? N2 C24 C25 C26 -59.6(4) . . . . ? N2 C24 C25 C30 119.3(4) . . . . ? N3 C31 C32 C33 -139.6(3) . . . . ? N3 C31 C32 C37 44.4(4) . . . . ? N3 C40 C41 C42 -69.0(8) . . . . ? N3 C40 C41 C46 110.9(7) . . . . ? N3 C40A C41A C42A -124.0(15) . . . . ? N3 C40A C41A C46A 51(2) . . . . ? O1 C9 C10 C11 149.3(5) . . . . ? _iucr_refine_instructions_details ; 201810415.res created by SHELXL-2014/7 TITL CF solution in P21/n CELL 1.54184 10.207758 19.151985 18.951385 90 94.8036 90 ZERR 4 0.000263 0.000509 0.000437 0 0.0024 0 LATT 1 SYMM 0.5-X,0.5+Y,0.5-Z SFAC C H Br N O UNIT 184 168 4 12 4 ISOR 0.01 0.02 C45A C44A C44 C45 C46 C43 C43A C42A C42 C41A C41 C46A EADP C40 C40A EADP C41 C41A EADP C46 C46A EADP C45 C45A EADP C44 C44A EADP C43 C43A EADP C42 C42A L.S. 4 0 0 PLAN 20 SIZE 0.1 0.14 0.18 MPLA C1 C2 C3 C4 C5 C6 MPLA C16 C17 C18 C19 C20 C21 MPLA C25 C26 C27 C28 C29 C30 MPLA C32 C33 C34 C35 C36 C37 MPLA C41 C42 C43 C44 C45 C46 BOND $h conf fmap 2 acta REM REM REM WGHT 0.112300 2.590600 FVAR 3.99491 0.77255 0.79264 BR1 3 -0.360094 0.906709 0.704012 11.00000 0.08302 0.14582 = 0.05055 0.00046 0.03099 0.03061 C1 1 -0.222698 0.813952 0.528179 11.00000 0.04026 0.04816 = 0.04945 0.00438 0.01635 -0.00191 AFIX 43 H1 2 -0.232754 0.770895 0.505688 11.00000 -1.20000 AFIX 0 C2 1 -0.284787 0.826616 0.589033 11.00000 0.04801 0.06386 = 0.05064 0.01671 0.01994 0.00159 AFIX 43 H2 2 -0.334857 0.791877 0.608069 11.00000 -1.20000 AFIX 0 C3 1 -0.272126 0.890384 0.620964 11.00000 0.04047 0.08093 = 0.03362 0.00301 0.00999 0.01580 C4 1 -0.198769 0.941887 0.595178 11.00000 0.05238 0.06131 = 0.05440 -0.01226 0.00907 0.00631 AFIX 43 H4 2 -0.192197 0.985329 0.617115 11.00000 -1.20000 AFIX 0 C5 1 -0.133633 0.928325 0.535258 11.00000 0.04268 0.04795 = 0.05558 0.00263 0.01382 -0.00182 AFIX 43 H5 2 -0.080523 0.962746 0.518019 11.00000 -1.20000 AFIX 0 C6 1 -0.145815 0.864889 0.500596 11.00000 0.02997 0.04599 = 0.03123 0.00591 0.00693 0.00486 C7 1 -0.069033 0.891014 0.383857 11.00000 0.03767 0.04590 = 0.03830 0.01206 0.00859 0.00679 C8 1 0.021912 0.878911 0.335944 11.00000 0.03668 0.04847 = 0.03931 0.01384 0.00834 0.00741 C9 1 0.019826 0.916893 0.270507 11.00000 0.05571 0.08356 = 0.05581 0.03371 0.02537 0.02293 C10 1 -0.076042 0.977977 0.260249 11.00000 0.07124 0.06895 = 0.05498 0.02244 0.00912 0.00954 AFIX 23 H10A 2 -0.032937 1.019940 0.279108 11.00000 -1.20000 H10B 2 -0.097389 0.985103 0.209925 11.00000 -1.20000 AFIX 0 C11 1 -0.201446 0.967848 0.295163 11.00000 0.04206 0.04507 = 0.03889 0.00648 -0.00078 0.00921 C12 1 -0.170364 0.949116 0.373620 11.00000 0.05207 0.05946 = 0.05032 0.01515 0.01100 0.01582 AFIX 23 H12A 2 -0.137588 0.990270 0.399193 11.00000 -1.20000 H12B 2 -0.250636 0.934590 0.393407 11.00000 -1.20000 AFIX 0 C13 1 -0.283346 0.908308 0.259425 11.00000 0.07165 0.08151 = 0.06776 -0.00200 -0.01371 0.00157 AFIX 137 H13A 2 -0.362683 0.902450 0.282635 11.00000 -1.50000 H13B 2 -0.233414 0.865789 0.262854 11.00000 -1.50000 H13C 2 -0.305087 0.919503 0.210466 11.00000 -1.50000 AFIX 0 C14 1 -0.287004 1.032470 0.290399 11.00000 0.08570 0.08075 = 0.06439 0.03098 0.01714 0.03780 AFIX 137 H14A 2 -0.367521 1.023166 0.311464 11.00000 -1.50000 H14B 2 -0.306309 1.045030 0.241595 11.00000 -1.50000 H14C 2 -0.241464 1.070216 0.315114 11.00000 -1.50000 AFIX 0 C15 1 0.122632 0.821761 0.351968 11.00000 0.03453 0.04272 = 0.02927 0.00346 0.00920 0.00465 AFIX 13 H15 2 0.155863 0.805895 0.307654 11.00000 -1.20000 AFIX 0 C16 1 0.235430 0.849075 0.400590 11.00000 0.03506 0.03418 = 0.03943 0.00313 0.00836 0.00429 C17 1 0.336342 0.886687 0.372714 11.00000 0.04089 0.05051 = 0.05327 0.00702 0.01621 0.00255 AFIX 43 H17 2 0.337523 0.891055 0.323897 11.00000 -1.20000 AFIX 0 C18 1 0.434463 0.917491 0.416815 11.00000 0.04171 0.05107 = 0.07886 0.01014 0.01133 -0.00884 AFIX 43 H18 2 0.501649 0.941909 0.397512 11.00000 -1.20000 AFIX 0 C19 1 0.433193 0.912192 0.489172 11.00000 0.04466 0.05036 = 0.07578 0.00411 -0.01193 -0.01121 AFIX 43 H19 2 0.498504 0.933539 0.518838 11.00000 -1.20000 AFIX 0 C20 1 0.333499 0.874673 0.517585 11.00000 0.05141 0.04131 = 0.04877 0.00375 -0.00819 -0.00440 AFIX 43 H20 2 0.332386 0.871605 0.566506 11.00000 -1.20000 AFIX 0 C21 1 0.235373 0.841622 0.474417 11.00000 0.04050 0.03341 = 0.03749 0.00190 0.00369 0.00135 C22 1 0.130757 0.799035 0.506342 11.00000 0.03578 0.03464 = 0.02587 0.00038 0.00292 0.00075 AFIX 13 H22 2 0.098585 0.826492 0.544966 11.00000 -1.20000 AFIX 0 C23 1 0.014362 0.786172 0.451747 11.00000 0.03107 0.03433 = 0.02774 0.00589 0.00418 0.00344 AFIX 13 H23 2 -0.038469 0.748478 0.469831 11.00000 -1.20000 AFIX 0 C24 1 -0.041814 0.728835 0.339450 11.00000 0.04859 0.04990 = 0.03056 0.00071 -0.00478 -0.00244 AFIX 23 H24A 2 -0.011479 0.723809 0.292560 11.00000 -1.20000 H24B 2 -0.119430 0.758257 0.335500 11.00000 -1.20000 AFIX 0 C25 1 -0.077302 0.658189 0.366750 11.00000 0.04310 0.04679 = 0.02904 -0.00621 -0.00253 -0.00598 C26 1 0.018638 0.606497 0.376238 11.00000 0.04179 0.05397 = 0.04116 -0.00763 0.00384 -0.00214 AFIX 43 H26 2 0.104091 0.615819 0.365404 11.00000 -1.20000 AFIX 0 C27 1 -0.012464 0.541485 0.401644 11.00000 0.06790 0.04628 = 0.06100 -0.00164 -0.00205 0.00012 AFIX 43 H27 2 0.052077 0.507211 0.407457 11.00000 -1.20000 AFIX 0 C28 1 -0.137720 0.527116 0.418348 11.00000 0.07681 0.05573 = 0.06142 0.00564 -0.00646 -0.02470 AFIX 43 H28 2 -0.158095 0.483189 0.435257 11.00000 -1.20000 AFIX 0 C29 1 -0.233145 0.577765 0.410056 11.00000 0.05256 0.08633 = 0.05736 0.00487 0.00269 -0.02802 AFIX 43 H29 2 -0.317936 0.568223 0.421850 11.00000 -1.20000 AFIX 0 C30 1 -0.203205 0.643268 0.384062 11.00000 0.04034 0.06793 = 0.04641 -0.00284 -0.00265 -0.00647 AFIX 43 H30 2 -0.268305 0.677248 0.378290 11.00000 -1.20000 AFIX 0 C31 1 0.175419 0.725547 0.537634 11.00000 0.03614 0.03575 = 0.03020 -0.00050 -0.00256 0.00142 AFIX 13 H31 2 0.176292 0.692164 0.498486 11.00000 -1.20000 AFIX 0 C32 1 0.074455 0.701612 0.586820 11.00000 0.04747 0.04037 = 0.03336 0.00997 0.00342 0.00609 C33 1 -0.029035 0.657026 0.565951 11.00000 0.05204 0.04245 = 0.04859 0.01110 0.00415 -0.00172 AFIX 43 H33 2 -0.032060 0.635435 0.521890 11.00000 -1.20000 AFIX 0 C34 1 -0.128076 0.644440 0.610416 11.00000 0.06126 0.06360 = 0.07629 0.02737 0.01269 -0.00703 AFIX 43 H34 2 -0.197612 0.615010 0.595849 11.00000 -1.20000 AFIX 0 C35 1 -0.123090 0.675331 0.675444 11.00000 0.07440 0.09446 = 0.06610 0.03684 0.02825 0.00658 AFIX 43 H35 2 -0.190568 0.667767 0.704619 11.00000 -1.20000 AFIX 0 C36 1 -0.017766 0.718096 0.698482 11.00000 0.09867 0.08723 = 0.03851 0.01558 0.01782 0.01704 AFIX 43 H36 2 -0.015268 0.738616 0.743051 11.00000 -1.20000 AFIX 0 C37 1 0.084338 0.730502 0.655245 11.00000 0.07214 0.05483 = 0.03181 0.00628 0.00637 0.00795 C38 1 0.206559 0.764677 0.678889 11.00000 0.09722 0.05994 = 0.02981 -0.00392 -0.00705 0.00265 AFIX 43 H38 2 0.211772 0.792635 0.719149 11.00000 -1.20000 AFIX 0 C39 1 0.312568 0.755757 0.642284 11.00000 0.06756 0.05673 = 0.04289 0.00546 -0.02551 -0.00604 AFIX 43 H39 2 0.394097 0.770509 0.662425 11.00000 -1.20000 AFIX 0 PART 1 C40 1 0.426220 0.711873 0.540876 21.00000 0.03778 0.05076 = 0.09481 -0.00227 -0.00232 0.00034 AFIX 23 H40A 2 0.494537 0.696544 0.576133 21.00000 -1.20000 H40B 2 0.455394 0.755185 0.520775 21.00000 -1.20000 AFIX 0 PART 0 PART 2 C40A 1 0.387642 0.666179 0.567898 -21.00000 0.03778 0.05076 = 0.09481 -0.00227 -0.00232 0.00034 AFIX 23 H40C 2 0.347668 0.625503 0.587767 -21.00000 -1.20000 H40D 2 0.471909 0.673874 0.594361 -21.00000 -1.20000 AFIX 0 PART 0 PART 1 C41 1 0.410345 0.658174 0.483491 31.00000 0.03232 0.05078 = 0.07298 0.00375 0.00817 0.00877 PART 0 PART 2 AFIX 66 C41A 1 0.409700 0.651723 0.492810 -31.00000 0.03232 0.05078 = 0.07298 0.00375 0.00817 0.00877 C42A 1 0.379978 0.587223 0.461869 -31.00000 0.05731 0.05329 = 0.07337 -0.00040 0.01163 0.00146 AFIX 43 H42A 2 0.352433 0.550611 0.489273 -31.00000 -1.20000 AFIX 65 C43A 1 0.391425 0.577443 0.389969 -31.00000 0.05909 0.05878 = 0.09451 -0.01220 0.01452 0.00134 AFIX 43 H43A 2 0.371538 0.534287 0.369268 -31.00000 -1.20000 AFIX 65 C44A 1 0.432594 0.632163 0.349010 -31.00000 0.05817 0.08663 = 0.08799 -0.02679 0.01000 0.00590 AFIX 43 H44A 2 0.440252 0.625619 0.300904 -31.00000 -1.20000 AFIX 65 C45A 1 0.462316 0.696664 0.379950 -31.00000 0.06237 0.11303 = 0.07112 0.00456 0.01686 0.01379 AFIX 43 H45A 2 0.489861 0.733275 0.352546 -31.00000 -1.20000 AFIX 65 C46A 1 0.450870 0.706445 0.451850 -31.00000 0.05376 0.07128 = 0.08643 0.01559 0.01483 0.00629 AFIX 43 H46A 2 0.470756 0.749600 0.472551 -31.00000 -1.20000 AFIX 0 PART 0 PART 1 C42 1 0.390297 0.588629 0.500045 31.00000 0.05731 0.05329 = 0.07337 -0.00040 0.01163 0.00146 AFIX 43 H42 2 0.387716 0.574859 0.546967 31.00000 -1.20000 AFIX 0 C43 1 0.374143 0.539850 0.445928 31.00000 0.05909 0.05878 = 0.09451 -0.01220 0.01452 0.00134 AFIX 43 H43 2 0.359607 0.493436 0.457403 31.00000 -1.20000 AFIX 0 C44 1 0.378806 0.557477 0.376742 31.00000 0.05817 0.08663 = 0.08799 -0.02679 0.01000 0.00590 AFIX 43 H44 2 0.368105 0.523788 0.341388 31.00000 -1.20000 AFIX 0 C45 1 0.399466 0.625470 0.360376 31.00000 0.06237 0.11303 = 0.07112 0.00456 0.01686 0.01379 AFIX 43 H45 2 0.403352 0.638300 0.313269 31.00000 -1.20000 AFIX 0 C46 1 0.414984 0.676480 0.413300 31.00000 0.05376 0.07128 = 0.08643 0.01559 0.01483 0.00629 AFIX 43 H46 2 0.428454 0.722819 0.401146 31.00000 -1.20000 AFIX 0 PART 0 N1 4 -0.072209 0.849353 0.442026 11.00000 0.03462 0.04160 = 0.03469 0.00922 0.01059 0.00688 N2 4 0.061131 0.762496 0.386287 11.00000 0.03420 0.03861 = 0.02578 0.00143 0.00207 0.00077 N3 4 0.305081 0.725753 0.576414 11.00000 0.04250 0.04889 = 0.04158 0.00218 -0.00843 0.00192 O1 5 0.094773 0.902757 0.224728 11.00000 0.08878 0.13029 = 0.06544 0.05559 0.04918 0.05488 HKLF 4 REM CF solution in P21/n REM R1 = 0.0701 for 5036 Fo > 4sig(Fo) and 0.0870 for all 6586 data REM 473 parameters refined using 72 restraints END WGHT 0.1123 2.5907 REM Highest difference peak 1.014, deepest hole -0.541, 1-sigma level 0.077 Q1 1 -0.1357 0.9301 0.2319 11.00000 0.05 1.01 Q2 1 -0.2861 0.9315 0.6978 11.00000 0.05 0.95 Q3 1 -0.1014 1.0303 0.3157 11.00000 0.05 0.89 Q4 1 -0.2204 0.9123 0.3484 11.00000 0.05 0.74 Q5 1 -0.3412 0.9863 0.2622 11.00000 0.05 0.69 Q6 1 -0.0247 0.8834 0.2450 11.00000 0.05 0.50 Q7 1 -0.2978 0.8663 0.7122 11.00000 0.05 0.36 Q8 1 -0.1013 0.8622 0.3569 11.00000 0.05 0.33 Q9 1 0.2353 0.8467 0.4365 11.00000 0.05 0.31 Q10 1 0.0399 0.7774 0.4198 11.00000 0.05 0.28 Q11 1 -0.4537 0.9438 0.6991 11.00000 0.05 0.27 Q12 1 0.3046 0.8896 0.3786 11.00000 0.05 0.27 Q13 1 -0.1429 0.6628 0.3867 11.00000 0.05 0.26 Q14 1 0.0762 0.7918 0.4814 11.00000 0.05 0.26 Q15 1 0.1624 0.8285 0.4883 11.00000 0.05 0.26 Q16 1 0.3450 0.9087 0.3961 11.00000 0.05 0.26 Q17 1 -0.1364 0.8472 0.4589 11.00000 0.05 0.25 Q18 1 -0.3835 0.8616 0.6806 11.00000 0.05 0.25 Q19 1 0.4123 0.5975 0.3713 11.00000 0.05 0.25 Q20 1 0.2694 0.8786 0.4946 11.00000 0.05 0.25 REM The information below was added by Olex2. REM REM R1 = 0.0701 for 5036 Fo > 4sig(Fo) and 0.0870 for all 14498 data REM n/a parameters refined using n/a restraints REM Highest difference peak 1.01, deepest hole -0.54 REM Mean Shift 0, Max Shift 0.001. REM +++ Tabular Listing of Refinement Information +++ REM R1_all = 0.0870 REM R1_gt = 0.0701 REM wR_ref = 0.2129 REM GOOF = 1.044 REM Shift_max = 0.001 REM Shift_mean = 0 REM Reflections_all = 14498 REM Reflections_gt = 5036 REM Parameters = n/a REM Hole = -0.54 REM Peak = 1.01 REM Flack = n/a ; _olex2_submission_special_instructions 'No special instructions were received' ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_201810620 _database_code_depnum_ccdc_archive 'CCDC 1947688' loop_ _audit_author_name _audit_author_address 'Qilin Wang' ;Henan University China ; _audit_update_record ; 2019-08-17 deposited with the CCDC. 2019-12-17 downloaded from the CCDC. ; _audit_creation_date 2018-10-28 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic ? _chemical_formula_moiety 'C28 H29 N3 O' _chemical_formula_sum 'C28 H29 N3 O' _chemical_formula_weight 423.54 _chemical_melting_point ? _chemical_oxdiff_formula C15H15O3N2 loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system monoclinic _space_group_IT_number 14 _space_group_name_H-M_alt 'P 1 21/c 1' _space_group_name_Hall '-P 2ybc' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y-1/2, z-1/2' _cell_length_a 9.0448(4) _cell_length_b 14.0503(6) _cell_length_c 18.8685(6) _cell_angle_alpha 90 _cell_angle_beta 102.053(4) _cell_angle_gamma 90 _cell_volume 2344.99(18) _cell_formula_units_Z 4 _cell_measurement_reflns_used 2345 _cell_measurement_temperature 293(2) _cell_measurement_theta_max 70.8790 _cell_measurement_theta_min 3.9340 _shelx_estimated_absorpt_T_max 0.929 _shelx_estimated_absorpt_T_min 0.879 _exptl_absorpt_coefficient_mu 0.573 _exptl_absorpt_correction_T_max ? _exptl_absorpt_correction_T_min ? _exptl_absorpt_correction_type none _exptl_absorpt_process_details ? _exptl_absorpt_special_details ? _exptl_crystal_colour yellow _exptl_crystal_colour_primary yellow _exptl_crystal_density_diffrn 1.200 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description prism _exptl_crystal_F_000 904 _exptl_crystal_size_max 0.23 _exptl_crystal_size_mid 0.16 _exptl_crystal_size_min 0.13 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0370 _diffrn_reflns_av_unetI/netI 0.0425 _diffrn_reflns_Laue_measured_fraction_full 1.000 _diffrn_reflns_Laue_measured_fraction_max 1.000 _diffrn_reflns_limit_h_max 10 _diffrn_reflns_limit_h_min -6 _diffrn_reflns_limit_k_max 16 _diffrn_reflns_limit_k_min -16 _diffrn_reflns_limit_l_max 21 _diffrn_reflns_limit_l_min -22 _diffrn_reflns_number 9364 _diffrn_reflns_point_group_measured_fraction_full 1.000 _diffrn_reflns_point_group_measured_fraction_max 1.000 _diffrn_reflns_theta_full 67.065 _diffrn_reflns_theta_max 67.065 _diffrn_reflns_theta_min 3.954 _diffrn_ambient_temperature 293(2) _diffrn_detector 'CCD plate' _diffrn_detector_area_resol_mean 16.2312 _diffrn_detector_type Eos _diffrn_measured_fraction_theta_full 1.000 _diffrn_measured_fraction_theta_max 1.000 _diffrn_measurement_details ; #__ type_ start__ end____ width___ exp.time_ 1 omega -46.00 8.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 37.0000 -60.0000 54 #__ type_ start__ end____ width___ exp.time_ 2 omega -41.00 -13.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 77.0000 0.0000 28 #__ type_ start__ end____ width___ exp.time_ 3 omega 10.00 36.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 77.0000 0.0000 26 #__ type_ start__ end____ width___ exp.time_ 4 omega 38.00 96.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 37.0000 -30.0000 58 #__ type_ start__ end____ width___ exp.time_ 5 omega 9.00 67.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 60.0000 58 #__ type_ start__ end____ width___ exp.time_ 6 omega -30.00 2.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -77.0000 -90.0000 32 #__ type_ start__ end____ width___ exp.time_ 7 omega 32.00 64.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 57.0000 -180.0000 32 #__ type_ start__ end____ width___ exp.time_ 8 omega 78.00 108.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -180.0000 30 #__ type_ start__ end____ width___ exp.time_ 9 omega 14.00 63.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -77.0000 -90.0000 49 #__ type_ start__ end____ width___ exp.time_ 10 omega 71.00 103.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 57.0000 -180.0000 32 #__ type_ start__ end____ width___ exp.time_ 11 omega 57.00 82.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -30.0000 25 #__ type_ start__ end____ width___ exp.time_ 12 omega 58.00 87.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -120.0000 29 #__ type_ start__ end____ width___ exp.time_ 13 omega 42.00 83.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 90.0000 41 #__ type_ start__ end____ width___ exp.time_ 14 omega 103.00 173.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 111.0000 60.0000 70 #__ type_ start__ end____ width___ exp.time_ 15 omega 90.00 177.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 45.0000 -120.0000 87 #__ type_ start__ end____ width___ exp.time_ 16 omega 38.00 89.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 120.0000 51 #__ type_ start__ end____ width___ exp.time_ 17 omega 134.00 175.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 61.0000 120.0000 41 #__ type_ start__ end____ width___ exp.time_ 18 omega 91.00 130.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 61.0000 120.0000 39 #__ type_ start__ end____ width___ exp.time_ 19 omega 42.00 98.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 30.0000 56 #__ type_ start__ end____ width___ exp.time_ 20 omega 74.00 109.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 30.0000 35 #__ type_ start__ end____ width___ exp.time_ 21 omega 60.00 86.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 -30.0000 26 #__ type_ start__ end____ width___ exp.time_ 22 omega 45.00 132.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -77.0000 90.0000 87 ; _diffrn_measurement_device 'four-circle diffractometer' _diffrn_measurement_device_type 'Xcalibur, Eos, Gemini' _diffrn_measurement_method '\w scans' _diffrn_orient_matrix_UB_11 -0.0012261000 _diffrn_orient_matrix_UB_12 0.0977823000 _diffrn_orient_matrix_UB_13 -0.0370444000 _diffrn_orient_matrix_UB_21 0.0409898000 _diffrn_orient_matrix_UB_22 0.0483960000 _diffrn_orient_matrix_UB_23 0.0748410000 _diffrn_orient_matrix_UB_31 0.1692540000 _diffrn_orient_matrix_UB_32 -0.0109986000 _diffrn_orient_matrix_UB_33 -0.0004882000 _diffrn_radiation_monochromator graphite _diffrn_radiation_probe x-ray _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54184 _diffrn_source 'Enhance (Cu) X-ray Source' _reflns_Friedel_coverage 0.000 _reflns_Friedel_fraction_full . _reflns_Friedel_fraction_max . _reflns_number_gt 2936 _reflns_number_total 4187 _reflns_odcompleteness_completeness 99.93 _reflns_odcompleteness_iscentric 1 _reflns_odcompleteness_theta 66.97 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_collection ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_reduction ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution 'ShelXS (Sheldrick, 2008)' _refine_diff_density_max 0.200 _refine_diff_density_min -0.134 _refine_diff_density_rms 0.033 _refine_ls_extinction_coef 0.0016(3) _refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc^2^\l^3^/sin(2\q)]^-1/4^ _refine_ls_extinction_method 'SHELXL-2014/7 (Sheldrick 2014' _refine_ls_goodness_of_fit_ref 1.032 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 293 _refine_ls_number_reflns 4187 _refine_ls_number_restraints 13 _refine_ls_R_factor_all 0.0727 _refine_ls_R_factor_gt 0.0527 _refine_ls_restrained_S_all 1.034 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0749P)^2^+0.1694P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1432 _refine_ls_wR_factor_ref 0.1669 _refine_special_details ? _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups At 1.5 times of: All C(H,H,H) groups 2. Rigid bond restraints C27, C26 with sigma for 1-2 distances of 0.001 and sigma for 1-3 distances of 0.001 3. Uiso/Uaniso restraints and constraints Uanis(C27) \\sim Ueq, Uanis(C26) \\sim Ueq: with sigma of 0.01 and sigma for terminal atoms of 0.02 4.a Ternary CH refined with riding coordinates: C17(H17), C21(H21) 4.b Secondary CH2 refined with riding coordinates: C4(H4A,H4B), C6(H6A,H6B), C20(H20A,H20B), C22(H22A,H22B) 4.c Aromatic/amide H refined with riding coordinates: C10(H10), C11(H11), C13(H13), C14(H14), C19(H19), C24(H24), C25(H25), C26(H26), C27(H27), C28(H28) 4.d Idealised Me refined as rotating group: C7(H7A,H7B,H7C), C8(H8A,H8B,H8C), C15(H15A,H15B,H15C) ; _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C1 C -0.0096(3) 0.44952(17) 0.14264(12) 0.0663(6) Uani 1 1 d . . . . . C2 C 0.0095(2) 0.39449(15) 0.20890(11) 0.0572(5) Uani 1 1 d . . . . . C3 C 0.1502(2) 0.36338(15) 0.24288(10) 0.0527(5) Uani 1 1 d . . . . . C4 C 0.2850(2) 0.37319(17) 0.20841(11) 0.0610(5) Uani 1 1 d . . . . . H4A H 0.3471 0.3166 0.2190 0.073 Uiso 1 1 calc R . . . . H4B H 0.3451 0.4270 0.2301 0.073 Uiso 1 1 calc R . . . . C5 C 0.2437(3) 0.38733(18) 0.12599(12) 0.0696(6) Uani 1 1 d . . . . . C6 C 0.1277(3) 0.46740(19) 0.11073(12) 0.0763(7) Uani 1 1 d . . . . . H6A H 0.1753 0.5263 0.1304 0.092 Uiso 1 1 calc R . . . . H6B H 0.0956 0.4753 0.0587 0.092 Uiso 1 1 calc R . . . . C7 C 0.1784(3) 0.2964(2) 0.08724(14) 0.0886(8) Uani 1 1 d . . . . . H7A H 0.2513 0.2460 0.0983 0.133 Uiso 1 1 calc GR . . . . H7B H 0.1548 0.3071 0.0359 0.133 Uiso 1 1 calc GR . . . . H7C H 0.0881 0.2788 0.1032 0.133 Uiso 1 1 calc GR . . . . C8 C 0.3879(4) 0.4152(3) 0.10028(16) 0.1029(10) Uani 1 1 d . . . . . H8A H 0.4334 0.4694 0.1272 0.154 Uiso 1 1 calc GR . . . . H8B H 0.3630 0.4306 0.0496 0.154 Uiso 1 1 calc GR . . . . H8C H 0.4577 0.3628 0.1079 0.154 Uiso 1 1 calc GR . . . . C9 C 0.3130(2) 0.28953(15) 0.35154(10) 0.0520(5) Uani 1 1 d . . . . . C10 C 0.3315(3) 0.19723(16) 0.37695(11) 0.0615(5) Uani 1 1 d . . . . . H10 H 0.2528 0.1537 0.3649 0.074 Uiso 1 1 calc R . . . . C11 C 0.4678(3) 0.1698(2) 0.42045(12) 0.0766(7) Uani 1 1 d . . . . . H11 H 0.4790 0.1077 0.4380 0.092 Uiso 1 1 calc R . . . . C12 C 0.5880(3) 0.2327(2) 0.43845(12) 0.0808(8) Uani 1 1 d . . . . . C13 C 0.5669(3) 0.3247(2) 0.41306(13) 0.0759(7) Uani 1 1 d . . . . . H13 H 0.6461 0.3680 0.4244 0.091 Uiso 1 1 calc R . . . . C14 C 0.4302(2) 0.35394(18) 0.37100(11) 0.0631(6) Uani 1 1 d . . . . . H14 H 0.4171 0.4169 0.3558 0.076 Uiso 1 1 calc R . . . . C15 C 0.7385(4) 0.2006(3) 0.48356(17) 0.1312(16) Uani 1 1 d . . . . . H15A H 0.7967 0.1704 0.4528 0.197 Uiso 1 1 calc GR . . . . H15B H 0.7215 0.1564 0.5198 0.197 Uiso 1 1 calc GR . . . . H15C H 0.7928 0.2548 0.5067 0.197 Uiso 1 1 calc GR . . . . C16 C 0.1136(3) 0.4325(2) 0.44500(13) 0.0794(7) Uani 1 1 d . . . . . C17 C 0.0357(2) 0.31558(17) 0.34279(11) 0.0592(5) Uani 1 1 d . . . . . H17 H 0.0527 0.2668 0.3808 0.071 Uiso 1 1 calc R . . . . C18 C 0.0146(2) 0.41061(19) 0.37683(11) 0.0658(6) Uani 1 1 d . . . . . C19 C -0.0904(3) 0.47289(19) 0.34621(13) 0.0709(6) Uani 1 1 d . . . . . H19 H -0.1014 0.5295 0.3702 0.085 Uiso 1 1 calc R . . . . C20 C -0.1908(3) 0.45382(19) 0.27427(13) 0.0712(6) Uani 1 1 d . . . . . H20A H -0.1959 0.5100 0.2439 0.085 Uiso 1 1 calc R . . . . H20B H -0.2922 0.4396 0.2806 0.085 Uiso 1 1 calc R . . . . C21 C -0.1305(2) 0.37038(17) 0.23762(12) 0.0616(5) Uani 1 1 d . . . . . H21 H -0.2097 0.3495 0.1969 0.074 Uiso 1 1 calc R . . . . C22 C -0.0889(2) 0.19810(17) 0.25761(14) 0.0691(6) Uani 1 1 d . . . . . H22A H -0.0487 0.1523 0.2952 0.083 Uiso 1 1 calc R . . . . H22B H -0.0199 0.2015 0.2246 0.083 Uiso 1 1 calc R . . . . C23 C -0.2416(2) 0.16519(16) 0.21696(12) 0.0600(5) Uani 1 1 d . . . . . C24 C -0.3624(3) 0.16116(18) 0.25149(13) 0.0682(6) Uani 1 1 d . . . . . H24 H -0.3488 0.1797 0.2997 0.082 Uiso 1 1 calc R . . . . C25 C -0.5019(3) 0.13024(19) 0.21552(15) 0.0750(7) Uani 1 1 d . . . . . H25 H -0.5814 0.1274 0.2397 0.090 Uiso 1 1 calc R . . . . C26 C -0.5248(3) 0.10363(19) 0.14476(15) 0.0791(7) Uani 1 1 d . U . . . H26 H -0.6196 0.0829 0.1206 0.095 Uiso 1 1 calc R . . . . C27 C -0.4071(3) 0.1075(2) 0.10918(14) 0.0834(7) Uani 1 1 d . U . . . H27 H -0.4226 0.0899 0.0607 0.100 Uiso 1 1 calc R . . . . C28 C -0.2650(3) 0.13762(19) 0.14543(13) 0.0741(7) Uani 1 1 d . . . . . H28 H -0.1853 0.1392 0.1213 0.089 Uiso 1 1 calc R . . . . N1 N 0.17020(18) 0.31888(13) 0.30858(9) 0.0555(4) Uani 1 1 d . . . . . N2 N 0.1918(3) 0.4500(2) 0.49875(12) 0.1054(9) Uani 1 1 d . . . . . N3 N -0.09900(19) 0.29201(14) 0.29061(10) 0.0612(5) Uani 1 1 d . . . . . O1 O -0.1332(2) 0.48328(14) 0.11377(9) 0.0904(6) Uani 1 1 d . . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 C1 0.0814(14) 0.0610(13) 0.0517(11) -0.0003(10) 0.0031(10) 0.0144(11) C2 0.0633(11) 0.0569(12) 0.0486(10) -0.0025(9) 0.0049(9) 0.0045(10) C3 0.0579(11) 0.0528(11) 0.0458(10) -0.0007(8) 0.0072(8) 0.0005(9) C4 0.0624(12) 0.0656(14) 0.0549(11) 0.0023(10) 0.0123(9) -0.0003(10) C5 0.0835(15) 0.0754(15) 0.0526(12) 0.0053(11) 0.0206(11) 0.0051(12) C6 0.1021(18) 0.0736(16) 0.0527(12) 0.0128(11) 0.0151(12) 0.0101(14) C7 0.103(2) 0.092(2) 0.0680(15) -0.0175(14) 0.0113(14) 0.0181(16) C8 0.113(2) 0.127(3) 0.0807(18) 0.0185(19) 0.0463(17) 0.000(2) C9 0.0524(10) 0.0584(12) 0.0446(9) -0.0004(8) 0.0086(8) 0.0055(9) C10 0.0723(13) 0.0629(13) 0.0499(11) 0.0028(10) 0.0145(9) 0.0076(11) C11 0.0958(18) 0.0846(18) 0.0494(12) 0.0076(11) 0.0155(12) 0.0369(15) C12 0.0729(15) 0.116(2) 0.0479(12) -0.0151(13) 0.0006(11) 0.0334(16) C13 0.0580(12) 0.106(2) 0.0604(13) -0.0191(14) 0.0043(10) -0.0002(13) C14 0.0604(12) 0.0709(14) 0.0561(12) -0.0070(10) 0.0078(9) -0.0011(10) C15 0.102(2) 0.188(4) 0.086(2) -0.029(2) -0.0215(17) 0.074(2) C16 0.0733(14) 0.107(2) 0.0579(13) -0.0102(13) 0.0145(12) 0.0050(14) C17 0.0504(10) 0.0746(14) 0.0521(11) 0.0080(10) 0.0094(8) 0.0003(10) C18 0.0592(12) 0.0882(17) 0.0508(11) -0.0058(11) 0.0135(9) -0.0008(12) C19 0.0671(13) 0.0818(17) 0.0645(13) -0.0116(12) 0.0156(11) 0.0060(12) C20 0.0608(12) 0.0802(16) 0.0701(14) -0.0070(12) 0.0078(10) 0.0145(12) C21 0.0520(11) 0.0706(14) 0.0572(11) -0.0048(10) 0.0002(9) 0.0054(10) C22 0.0584(12) 0.0643(14) 0.0842(16) 0.0021(12) 0.0141(11) -0.0004(10) C23 0.0595(11) 0.0585(13) 0.0618(12) 0.0017(10) 0.0122(9) -0.0015(10) C24 0.0666(13) 0.0745(15) 0.0651(13) -0.0090(11) 0.0171(10) -0.0060(11) C25 0.0587(12) 0.0752(17) 0.0917(17) -0.0118(13) 0.0168(12) -0.0052(11) C26 0.0714(13) 0.0677(15) 0.0878(17) -0.0014(13) -0.0069(10) -0.0052(12) C27 0.1083(18) 0.0800(17) 0.0566(13) -0.0001(12) 0.0051(12) -0.0058(15) C28 0.0835(16) 0.0757(16) 0.0673(14) -0.0003(12) 0.0248(12) -0.0067(13) N1 0.0506(9) 0.0658(11) 0.0488(9) 0.0065(8) 0.0074(7) 0.0002(8) N2 0.0942(16) 0.153(3) 0.0607(13) -0.0246(14) -0.0019(12) 0.0166(17) N3 0.0508(9) 0.0659(12) 0.0652(10) -0.0004(9) 0.0084(8) -0.0007(8) O1 0.0974(13) 0.0954(14) 0.0700(10) 0.0131(10) -0.0018(9) 0.0357(11) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag C1 C2 1.449(3) . ? C1 C6 1.510(3) . ? C1 O1 1.232(3) . ? C2 C3 1.372(3) . ? C2 C21 1.516(3) . ? C3 C4 1.503(3) . ? C3 N1 1.366(2) . ? C4 H4A 0.9700 . ? C4 H4B 0.9700 . ? C4 C5 1.535(3) . ? C5 C6 1.524(3) . ? C5 C7 1.529(4) . ? C5 C8 1.535(4) . ? C6 H6A 0.9700 . ? C6 H6B 0.9700 . ? C7 H7A 0.9600 . ? C7 H7B 0.9600 . ? C7 H7C 0.9600 . ? C8 H8A 0.9600 . ? C8 H8B 0.9600 . ? C8 H8C 0.9600 . ? C9 C10 1.381(3) . ? C9 C14 1.384(3) . ? C9 N1 1.434(2) . ? C10 H10 0.9300 . ? C10 C11 1.386(3) . ? C11 H11 0.9300 . ? C11 C12 1.388(4) . ? C12 C13 1.377(4) . ? C12 C15 1.516(3) . ? C13 H13 0.9300 . ? C13 C14 1.385(3) . ? C14 H14 0.9300 . ? C15 H15A 0.9600 . ? C15 H15B 0.9600 . ? C15 H15C 0.9600 . ? C16 C18 1.439(3) . ? C16 N2 1.136(3) . ? C17 H17 0.9800 . ? C17 C18 1.511(3) . ? C17 N1 1.492(2) . ? C17 N3 1.436(3) . ? C18 C19 1.331(3) . ? C19 H19 0.9300 . ? C19 C20 1.491(3) . ? C20 H20A 0.9700 . ? C20 H20B 0.9700 . ? C20 C21 1.519(3) . ? C21 H21 0.9800 . ? C21 N3 1.475(3) . ? C22 H22A 0.9700 . ? C22 H22B 0.9700 . ? C22 C23 1.506(3) . ? C22 N3 1.470(3) . ? C23 C24 1.385(3) . ? C23 C28 1.377(3) . ? C24 H24 0.9300 . ? C24 C25 1.372(3) . ? C25 H25 0.9300 . ? C25 C26 1.360(4) . ? C26 H26 0.9300 . ? C26 C27 1.373(4) . ? C27 H27 0.9300 . ? C27 C28 1.390(4) . ? C28 H28 0.9300 . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C2 C1 C6 118.23(19) . . ? O1 C1 C2 121.3(2) . . ? O1 C1 C6 120.4(2) . . ? C1 C2 C21 118.03(19) . . ? C3 C2 C1 120.3(2) . . ? C3 C2 C21 121.63(18) . . ? C2 C3 C4 121.73(18) . . ? N1 C3 C2 120.25(19) . . ? N1 C3 C4 117.97(17) . . ? C3 C4 H4A 108.8 . . ? C3 C4 H4B 108.8 . . ? C3 C4 C5 113.72(18) . . ? H4A C4 H4B 107.7 . . ? C5 C4 H4A 108.8 . . ? C5 C4 H4B 108.8 . . ? C4 C5 C8 108.1(2) . . ? C6 C5 C4 107.43(19) . . ? C6 C5 C7 110.2(2) . . ? C6 C5 C8 110.4(2) . . ? C7 C5 C4 111.4(2) . . ? C7 C5 C8 109.3(2) . . ? C1 C6 C5 113.1(2) . . ? C1 C6 H6A 109.0 . . ? C1 C6 H6B 109.0 . . ? C5 C6 H6A 109.0 . . ? C5 C6 H6B 109.0 . . ? H6A C6 H6B 107.8 . . ? C5 C7 H7A 109.5 . . ? C5 C7 H7B 109.5 . . ? C5 C7 H7C 109.5 . . ? H7A C7 H7B 109.5 . . ? H7A C7 H7C 109.5 . . ? H7B C7 H7C 109.5 . . ? C5 C8 H8A 109.5 . . ? C5 C8 H8B 109.5 . . ? C5 C8 H8C 109.5 . . ? H8A C8 H8B 109.5 . . ? H8A C8 H8C 109.5 . . ? H8B C8 H8C 109.5 . . ? C10 C9 C14 119.4(2) . . ? C10 C9 N1 119.73(19) . . ? C14 C9 N1 120.75(19) . . ? C9 C10 H10 120.1 . . ? C9 C10 C11 119.7(2) . . ? C11 C10 H10 120.1 . . ? C10 C11 H11 119.3 . . ? C10 C11 C12 121.5(3) . . ? C12 C11 H11 119.3 . . ? C11 C12 C15 120.9(3) . . ? C13 C12 C11 117.9(2) . . ? C13 C12 C15 121.1(3) . . ? C12 C13 H13 119.3 . . ? C12 C13 C14 121.3(2) . . ? C14 C13 H13 119.3 . . ? C9 C14 C13 120.1(2) . . ? C9 C14 H14 120.0 . . ? C13 C14 H14 120.0 . . ? C12 C15 H15A 109.5 . . ? C12 C15 H15B 109.5 . . ? C12 C15 H15C 109.5 . . ? H15A C15 H15B 109.5 . . ? H15A C15 H15C 109.5 . . ? H15B C15 H15C 109.5 . . ? N2 C16 C18 179.8(4) . . ? C18 C17 H17 108.7 . . ? N1 C17 H17 108.7 . . ? N1 C17 C18 110.08(18) . . ? N3 C17 H17 108.7 . . ? N3 C17 C18 109.31(18) . . ? N3 C17 N1 111.23(16) . . ? C16 C18 C17 117.3(2) . . ? C19 C18 C16 120.1(2) . . ? C19 C18 C17 122.6(2) . . ? C18 C19 H19 119.3 . . ? C18 C19 C20 121.4(2) . . ? C20 C19 H19 119.3 . . ? C19 C20 H20A 109.6 . . ? C19 C20 H20B 109.6 . . ? C19 C20 C21 110.16(19) . . ? H20A C20 H20B 108.1 . . ? C21 C20 H20A 109.6 . . ? C21 C20 H20B 109.6 . . ? C2 C21 C20 113.4(2) . . ? C2 C21 H21 108.3 . . ? C20 C21 H21 108.3 . . ? N3 C21 C2 110.61(16) . . ? N3 C21 C20 107.73(19) . . ? N3 C21 H21 108.3 . . ? H22A C22 H22B 108.0 . . ? C23 C22 H22A 109.4 . . ? C23 C22 H22B 109.4 . . ? N3 C22 H22A 109.4 . . ? N3 C22 H22B 109.4 . . ? N3 C22 C23 111.07(18) . . ? C24 C23 C22 120.2(2) . . ? C28 C23 C22 121.5(2) . . ? C28 C23 C24 118.3(2) . . ? C23 C24 H24 119.5 . . ? C25 C24 C23 120.9(2) . . ? C25 C24 H24 119.5 . . ? C24 C25 H25 119.7 . . ? C26 C25 C24 120.6(2) . . ? C26 C25 H25 119.7 . . ? C25 C26 H26 120.2 . . ? C25 C26 C27 119.6(2) . . ? C27 C26 H26 120.2 . . ? C26 C27 H27 119.9 . . ? C26 C27 C28 120.2(2) . . ? C28 C27 H27 119.9 . . ? C23 C28 C27 120.3(2) . . ? C23 C28 H28 119.8 . . ? C27 C28 H28 119.8 . . ? C3 N1 C9 125.25(16) . . ? C3 N1 C17 116.19(16) . . ? C9 N1 C17 117.76(15) . . ? C17 N3 C21 107.98(17) . . ? C17 N3 C22 112.23(18) . . ? C22 N3 C21 113.78(18) . . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag C1 C2 C3 C4 -8.3(3) . . . . ? C1 C2 C3 N1 174.19(19) . . . . ? C1 C2 C21 C20 -76.1(2) . . . . ? C1 C2 C21 N3 162.79(19) . . . . ? C2 C1 C6 C5 30.8(3) . . . . ? C2 C3 C4 C5 -19.8(3) . . . . ? C2 C3 N1 C9 -175.26(19) . . . . ? C2 C3 N1 C17 -5.8(3) . . . . ? C2 C21 N3 C17 50.4(2) . . . . ? C2 C21 N3 C22 -74.9(2) . . . . ? C3 C2 C21 C20 105.7(2) . . . . ? C3 C2 C21 N3 -15.4(3) . . . . ? C3 C4 C5 C6 50.2(3) . . . . ? C3 C4 C5 C7 -70.6(3) . . . . ? C3 C4 C5 C8 169.3(2) . . . . ? C4 C3 N1 C9 7.2(3) . . . . ? C4 C3 N1 C17 176.63(18) . . . . ? C4 C5 C6 C1 -55.5(3) . . . . ? C6 C1 C2 C3 2.7(3) . . . . ? C6 C1 C2 C21 -175.5(2) . . . . ? C7 C5 C6 C1 66.0(3) . . . . ? C8 C5 C6 C1 -173.2(2) . . . . ? C9 C10 C11 C12 -1.0(3) . . . . ? C10 C9 C14 C13 2.8(3) . . . . ? C10 C9 N1 C3 -128.6(2) . . . . ? C10 C9 N1 C17 62.1(3) . . . . ? C10 C11 C12 C13 1.4(3) . . . . ? C10 C11 C12 C15 -177.5(2) . . . . ? C11 C12 C13 C14 0.2(3) . . . . ? C12 C13 C14 C9 -2.3(3) . . . . ? C14 C9 C10 C11 -1.2(3) . . . . ? C14 C9 N1 C3 54.8(3) . . . . ? C14 C9 N1 C17 -114.5(2) . . . . ? C15 C12 C13 C14 179.1(2) . . . . ? C16 C18 C19 C20 177.7(2) . . . . ? C17 C18 C19 C20 -2.4(4) . . . . ? C18 C17 N1 C3 -78.0(2) . . . . ? C18 C17 N1 C9 92.3(2) . . . . ? C18 C17 N3 C21 56.4(2) . . . . ? C18 C17 N3 C22 -177.44(18) . . . . ? C18 C19 C20 C21 -13.1(3) . . . . ? C19 C20 C21 C2 -73.4(3) . . . . ? C19 C20 C21 N3 49.3(3) . . . . ? C20 C21 N3 C17 -74.0(2) . . . . ? C20 C21 N3 C22 160.73(18) . . . . ? C21 C2 C3 C4 169.81(19) . . . . ? C21 C2 C3 N1 -7.7(3) . . . . ? C22 C23 C24 C25 -179.2(2) . . . . ? C22 C23 C28 C27 180.0(2) . . . . ? C23 C22 N3 C17 166.70(18) . . . . ? C23 C22 N3 C21 -70.3(2) . . . . ? C23 C24 C25 C26 -0.6(4) . . . . ? C24 C23 C28 C27 0.6(4) . . . . ? C24 C25 C26 C27 0.2(4) . . . . ? C25 C26 C27 C28 0.6(4) . . . . ? C26 C27 C28 C23 -1.0(4) . . . . ? C28 C23 C24 C25 0.2(4) . . . . ? N1 C3 C4 C5 157.7(2) . . . . ? N1 C9 C10 C11 -177.85(18) . . . . ? N1 C9 C14 C13 179.41(19) . . . . ? N1 C17 C18 C16 -76.9(2) . . . . ? N1 C17 C18 C19 103.1(2) . . . . ? N1 C17 N3 C21 -65.4(2) . . . . ? N1 C17 N3 C22 60.8(2) . . . . ? N3 C17 C18 C16 160.6(2) . . . . ? N3 C17 C18 C19 -19.4(3) . . . . ? N3 C17 N1 C3 43.3(3) . . . . ? N3 C17 N1 C9 -146.42(19) . . . . ? N3 C22 C23 C24 -54.5(3) . . . . ? N3 C22 C23 C28 126.1(2) . . . . ? O1 C1 C2 C3 -175.3(2) . . . . ? O1 C1 C2 C21 6.5(3) . . . . ? O1 C1 C6 C5 -151.1(2) . . . . ? _iucr_refine_instructions_details ; 201810620.res created by SHELXL-2014/7 TITL 201810620 in P21/c #14 REM reset to P21/c #14 CELL 1.54184 9.044821 14.050282 18.868499 90 102.0528 90 ZERR 4 0.000448 0.000616 0.000629 0 0.0037 0 LATT 1 SYMM -X,0.5+Y,0.5-Z SFAC C H N O UNIT 112 116 12 4 DELU 0.001 0.001 C27 C26 ISOR 0.01 0.02 C27 C26 L.S. 4 0 0 PLAN 20 SIZE 0.13 0.16 0.23 MPLA C1 C2 C3 C4 C6 MPLA C4 C5 C6 MPLA C9 C10 C11 C12 C13 C14 MPLA C23 C24 C25 C26 C27 C28 bond $h conf fmap 2 acta REM REM REM WGHT 0.074900 0.169400 EXTI 0.001603 FVAR 6.54905 C1 1 -0.009598 0.449525 0.142636 11.00000 0.08138 0.06096 = 0.05173 -0.00031 0.00314 0.01440 C2 1 0.009460 0.394493 0.208903 11.00000 0.06325 0.05692 = 0.04861 -0.00245 0.00495 0.00448 C3 1 0.150224 0.363378 0.242883 11.00000 0.05787 0.05283 = 0.04576 -0.00068 0.00715 0.00055 C4 1 0.285038 0.373192 0.208411 11.00000 0.06244 0.06563 = 0.05490 0.00226 0.01232 -0.00025 AFIX 23 H4A 2 0.347083 0.316568 0.218976 11.00000 -1.20000 H4B 2 0.345079 0.427006 0.230067 11.00000 -1.20000 AFIX 0 C5 1 0.243681 0.387327 0.125992 11.00000 0.08352 0.07538 = 0.05259 0.00527 0.02059 0.00506 C6 1 0.127745 0.467400 0.110732 11.00000 0.10212 0.07364 = 0.05273 0.01280 0.01514 0.01010 AFIX 23 H6A 2 0.175289 0.526287 0.130434 11.00000 -1.20000 H6B 2 0.095620 0.475322 0.058719 11.00000 -1.20000 AFIX 0 C7 1 0.178384 0.296369 0.087239 11.00000 0.10264 0.09226 = 0.06795 -0.01748 0.01127 0.01809 AFIX 137 H7A 2 0.251260 0.245991 0.098296 11.00000 -1.50000 H7B 2 0.154812 0.307143 0.035868 11.00000 -1.50000 H7C 2 0.088070 0.278847 0.103215 11.00000 -1.50000 AFIX 0 C8 1 0.387946 0.415158 0.100283 11.00000 0.11264 0.12686 = 0.08065 0.01848 0.04629 0.00009 AFIX 137 H8A 2 0.433393 0.469431 0.127224 11.00000 -1.50000 H8B 2 0.362951 0.430611 0.049626 11.00000 -1.50000 H8C 2 0.457738 0.362840 0.107917 11.00000 -1.50000 AFIX 0 C9 1 0.312970 0.289528 0.351535 11.00000 0.05243 0.05842 = 0.04459 -0.00037 0.00858 0.00555 C10 1 0.331499 0.197233 0.376945 11.00000 0.07230 0.06292 = 0.04993 0.00278 0.01451 0.00760 AFIX 43 H10 2 0.252822 0.153681 0.364914 11.00000 -1.20000 AFIX 0 C11 1 0.467792 0.169757 0.420445 11.00000 0.09584 0.08457 = 0.04940 0.00763 0.01551 0.03691 AFIX 43 H11 2 0.478974 0.107736 0.437965 11.00000 -1.20000 AFIX 0 C12 1 0.587965 0.232723 0.438448 11.00000 0.07292 0.11625 = 0.04793 -0.01506 0.00056 0.03341 C13 1 0.566902 0.324689 0.413059 11.00000 0.05801 0.10582 = 0.06038 -0.01912 0.00434 -0.00015 AFIX 43 H13 2 0.646073 0.368003 0.424381 11.00000 -1.20000 AFIX 0 C14 1 0.430164 0.353941 0.371001 11.00000 0.06043 0.07087 = 0.05612 -0.00703 0.00778 -0.00111 AFIX 43 H14 2 0.417099 0.416925 0.355831 11.00000 -1.20000 AFIX 0 C15 1 0.738518 0.200647 0.483558 11.00000 0.10171 0.18827 = 0.08562 -0.02880 -0.02147 0.07425 AFIX 137 H15A 2 0.796671 0.170422 0.452788 11.00000 -1.50000 H15B 2 0.721471 0.156362 0.519764 11.00000 -1.50000 H15C 2 0.792759 0.254843 0.506690 11.00000 -1.50000 AFIX 0 C16 1 0.113563 0.432477 0.444999 11.00000 0.07334 0.10724 = 0.05790 -0.01021 0.01451 0.00496 C17 1 0.035704 0.315579 0.342792 11.00000 0.05040 0.07456 = 0.05207 0.00800 0.00940 0.00033 AFIX 13 H17 2 0.052651 0.266837 0.380780 11.00000 -1.20000 AFIX 0 C18 1 0.014568 0.410608 0.376830 11.00000 0.05924 0.08815 = 0.05081 -0.00578 0.01354 -0.00079 C19 1 -0.090439 0.472894 0.346211 11.00000 0.06711 0.08181 = 0.06449 -0.01159 0.01556 0.00601 AFIX 43 H19 2 -0.101420 0.529463 0.370182 11.00000 -1.20000 AFIX 0 C20 1 -0.190820 0.453823 0.274267 11.00000 0.06081 0.08024 = 0.07014 -0.00703 0.00783 0.01445 AFIX 23 H20A 2 -0.195872 0.509953 0.243923 11.00000 -1.20000 H20B 2 -0.292182 0.439589 0.280629 11.00000 -1.20000 AFIX 0 C21 1 -0.130478 0.370382 0.237620 11.00000 0.05200 0.07059 = 0.05723 -0.00477 0.00023 0.00543 AFIX 13 H21 2 -0.209691 0.349521 0.196868 11.00000 -1.20000 AFIX 0 C22 1 -0.088862 0.198102 0.257610 11.00000 0.05838 0.06425 = 0.08422 0.00213 0.01412 -0.00038 AFIX 23 H22A 2 -0.048681 0.152324 0.295188 11.00000 -1.20000 H22B 2 -0.019939 0.201547 0.224606 11.00000 -1.20000 AFIX 0 C23 1 -0.241604 0.165191 0.216959 11.00000 0.05951 0.05855 = 0.06185 0.00168 0.01218 -0.00150 C24 1 -0.362408 0.161165 0.251487 11.00000 0.06658 0.07453 = 0.06511 -0.00902 0.01714 -0.00599 AFIX 43 H24 2 -0.348802 0.179688 0.299737 11.00000 -1.20000 AFIX 0 C25 1 -0.501866 0.130236 0.215518 11.00000 0.05874 0.07517 = 0.09168 -0.01181 0.01684 -0.00524 AFIX 43 H25 2 -0.581388 0.127447 0.239735 11.00000 -1.20000 AFIX 0 C26 1 -0.524792 0.103626 0.144762 11.00000 0.07145 0.06767 = 0.08778 -0.00139 -0.00687 -0.00525 AFIX 43 H26 2 -0.619636 0.082915 0.120618 11.00000 -1.20000 AFIX 0 C27 1 -0.407125 0.107512 0.109177 11.00000 0.10829 0.08002 = 0.05658 -0.00006 0.00507 -0.00581 AFIX 43 H27 2 -0.422560 0.089947 0.060665 11.00000 -1.20000 AFIX 0 C28 1 -0.264971 0.137621 0.145434 11.00000 0.08348 0.07565 = 0.06726 -0.00028 0.02478 -0.00670 AFIX 43 H28 2 -0.185283 0.139154 0.121278 11.00000 -1.20000 AFIX 0 N1 3 0.170199 0.318875 0.308580 11.00000 0.05058 0.06583 = 0.04883 0.00650 0.00735 0.00020 N2 3 0.191835 0.450017 0.498750 11.00000 0.09419 0.15337 = 0.06074 -0.02462 -0.00194 0.01657 N3 3 -0.099002 0.292006 0.290613 11.00000 0.05085 0.06588 = 0.06525 -0.00035 0.00843 -0.00072 O1 4 -0.133210 0.483283 0.113774 11.00000 0.09740 0.09542 = 0.07003 0.01312 -0.00180 0.03571 HKLF 4 REM 201810620 in P21/c #14 REM R1 = 0.0527 for 2936 Fo > 4sig(Fo) and 0.0727 for all 4187 data REM 293 parameters refined using 13 restraints END WGHT 0.0749 0.1695 REM Highest difference peak 0.200, deepest hole -0.134, 1-sigma level 0.033 Q1 1 0.7364 0.2159 0.5332 11.00000 0.05 0.20 Q2 1 0.0202 0.4138 0.1910 11.00000 0.05 0.15 Q3 1 -0.3185 0.1992 0.2193 11.00000 0.05 0.14 Q4 1 0.2651 0.3820 0.1700 11.00000 0.05 0.14 Q5 1 0.0788 0.3463 0.2073 11.00000 0.05 0.14 Q6 1 -0.2345 0.1084 0.1911 11.00000 0.05 0.14 Q7 1 0.0538 0.4104 0.2265 11.00000 0.05 0.14 Q8 1 -0.0321 0.4210 0.2370 11.00000 0.05 0.13 Q9 1 0.1657 0.2807 0.2678 11.00000 0.05 0.13 Q10 1 -0.1945 0.2793 0.3217 11.00000 0.05 0.13 Q11 1 0.1614 0.3352 0.2790 11.00000 0.05 0.13 Q12 1 -0.2548 0.1806 0.1824 11.00000 0.05 0.13 Q13 1 0.1094 0.4032 0.5011 11.00000 0.05 0.12 Q14 1 0.7387 0.1168 0.4757 11.00000 0.05 0.12 Q15 1 -0.5613 0.0902 0.2723 11.00000 0.05 0.12 Q16 1 0.7072 0.1030 0.5021 11.00000 0.05 0.11 Q17 1 -0.4987 0.1341 0.1713 11.00000 0.05 0.11 Q18 1 -0.4742 0.1359 0.1199 11.00000 0.05 0.11 Q19 1 -0.1372 0.3998 0.2583 11.00000 0.05 0.10 Q20 1 0.2346 0.3923 0.2201 11.00000 0.05 0.10 REM The information below was added by Olex2. REM REM R1 = 0.0527 for 2936 Fo > 4sig(Fo) and 0.0727 for all 9661 data REM n/a parameters refined using n/a restraints REM Highest difference peak 0.20, deepest hole -0.13 REM Mean Shift 0, Max Shift 0.000. REM +++ Tabular Listing of Refinement Information +++ REM R1_all = 0.0727 REM R1_gt = 0.0527 REM wR_ref = 0.1669 REM GOOF = 1.032 REM Shift_max = 0.000 REM Shift_mean = 0 REM Reflections_all = 9661 REM Reflections_gt = 2936 REM Parameters = n/a REM Hole = -0.13 REM Peak = 0.20 REM Flack = n/a ; _olex2_submission_special_instructions 'No special instructions were received' ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_20190484 _database_code_depnum_ccdc_archive 'CCDC 1947691' loop_ _audit_author_name _audit_author_address 'Qilin Wang' ;Henan University China ; _audit_update_record ; 2019-08-17 deposited with the CCDC. 2019-12-17 downloaded from the CCDC. ; _audit_creation_date 2019-04-12 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic ? _chemical_formula_moiety 'C31 H31 Br N2 O' _chemical_formula_sum 'C31 H31 Br N2 O' _chemical_formula_weight 527.49 _chemical_melting_point ? _chemical_oxdiff_formula C20H20N4O4Br1 loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' Br Br -0.6763 1.2805 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system monoclinic _space_group_IT_number 14 _space_group_name_H-M_alt 'P 1 21/n 1' _space_group_name_Hall '-P 2yn' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x+1/2, y+1/2, -z+1/2' '-x, -y, -z' 'x-1/2, -y-1/2, z-1/2' _cell_length_a 14.4850(5) _cell_length_b 10.8239(5) _cell_length_c 16.4134(7) _cell_angle_alpha 90 _cell_angle_beta 90.869(3) _cell_angle_gamma 90 _cell_volume 2573.07(18) _cell_formula_units_Z 4 _cell_measurement_reflns_used 3325 _cell_measurement_temperature 293(2) _cell_measurement_theta_max 70.7610 _cell_measurement_theta_min 4.0450 _shelx_estimated_absorpt_T_max 0.797 _shelx_estimated_absorpt_T_min 0.689 _exptl_absorpt_coefficient_mu 2.372 _exptl_absorpt_correction_T_max 1.00000 _exptl_absorpt_correction_T_min 0.90797 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. ; _exptl_absorpt_special_details ? _exptl_crystal_colour colourless _exptl_crystal_colour_primary colourless _exptl_crystal_density_diffrn 1.362 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description prism _exptl_crystal_F_000 1096 _exptl_crystal_size_max 0.17 _exptl_crystal_size_mid 0.13 _exptl_crystal_size_min 0.1 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0341 _diffrn_reflns_av_unetI/netI 0.0441 _diffrn_reflns_Laue_measured_fraction_full 1.000 _diffrn_reflns_Laue_measured_fraction_max 1.000 _diffrn_reflns_limit_h_max 17 _diffrn_reflns_limit_h_min -16 _diffrn_reflns_limit_k_max 12 _diffrn_reflns_limit_k_min -12 _diffrn_reflns_limit_l_max 13 _diffrn_reflns_limit_l_min -19 _diffrn_reflns_number 10451 _diffrn_reflns_point_group_measured_fraction_full 1.000 _diffrn_reflns_point_group_measured_fraction_max 1.000 _diffrn_reflns_theta_full 67.055 _diffrn_reflns_theta_max 67.055 _diffrn_reflns_theta_min 4.040 _diffrn_ambient_temperature 293(2) _diffrn_detector 'CCD plate' _diffrn_detector_area_resol_mean 16.2312 _diffrn_detector_type Eos _diffrn_measured_fraction_theta_full 1.000 _diffrn_measured_fraction_theta_max 1.000 _diffrn_measurement_details ; #__ type_ start__ end____ width___ exp.time_ 1 omega -101.00 -17.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 -57.0000 0.0000 84 #__ type_ start__ end____ width___ exp.time_ 2 omega -108.00 -75.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 30.0000 33 #__ type_ start__ end____ width___ exp.time_ 3 omega -3.00 22.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 -180.0000 25 #__ type_ start__ end____ width___ exp.time_ 4 omega 58.00 85.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -180.0000 27 #__ type_ start__ end____ width___ exp.time_ 5 omega 18.00 58.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -37.0000 30.0000 40 #__ type_ start__ end____ width___ exp.time_ 6 omega 45.00 71.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 -150.0000 26 #__ type_ start__ end____ width___ exp.time_ 7 omega -31.00 21.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -57.0000 -60.0000 52 #__ type_ start__ end____ width___ exp.time_ 8 omega 0.00 26.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 -150.0000 26 #__ type_ start__ end____ width___ exp.time_ 9 omega -33.00 -7.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -37.0000 -150.0000 26 #__ type_ start__ end____ width___ exp.time_ 10 omega 13.00 59.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -37.0000 -150.0000 46 #__ type_ start__ end____ width___ exp.time_ 11 omega -31.00 -5.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -37.0000 30.0000 26 #__ type_ start__ end____ width___ exp.time_ 12 omega 1.00 38.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 90.0000 37 #__ type_ start__ end____ width___ exp.time_ 13 omega 52.00 77.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 90.0000 25 #__ type_ start__ end____ width___ exp.time_ 14 omega 38.00 71.00 1.0000 1.0000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 -180.0000 33 #__ type_ start__ end____ width___ exp.time_ 15 omega 58.00 87.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 -150.0000 29 #__ type_ start__ end____ width___ exp.time_ 16 omega 60.00 91.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 120.0000 31 #__ type_ start__ end____ width___ exp.time_ 17 omega 41.00 106.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 30.0000 65 #__ type_ start__ end____ width___ exp.time_ 18 omega 42.00 97.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 90.0000 55 #__ type_ start__ end____ width___ exp.time_ 19 omega 67.00 113.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 -180.0000 46 #__ type_ start__ end____ width___ exp.time_ 20 omega 38.00 72.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 -30.0000 34 #__ type_ start__ end____ width___ exp.time_ 21 omega 47.00 78.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 -150.0000 31 #__ type_ start__ end____ width___ exp.time_ 22 omega 134.00 175.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 61.0000 -150.0000 41 #__ type_ start__ end____ width___ exp.time_ 23 omega 103.00 129.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 61.0000 -150.0000 26 #__ type_ start__ end____ width___ exp.time_ 24 omega 57.00 99.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 30.0000 42 #__ type_ start__ end____ width___ exp.time_ 25 omega 67.00 109.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 90.0000 42 #__ type_ start__ end____ width___ exp.time_ 26 omega 87.00 174.00 1.0000 2.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 30.0000 -90.0000 87 ; _diffrn_measurement_device 'four-circle diffractometer' _diffrn_measurement_device_type 'Xcalibur, Eos, Gemini' _diffrn_measurement_method '\w scans' _diffrn_orient_matrix_UB_11 -0.0560458000 _diffrn_orient_matrix_UB_12 -0.0882394000 _diffrn_orient_matrix_UB_13 -0.0553746000 _diffrn_orient_matrix_UB_21 -0.0365383000 _diffrn_orient_matrix_UB_22 0.1112162000 _diffrn_orient_matrix_UB_23 -0.0494024000 _diffrn_orient_matrix_UB_31 0.0826638000 _diffrn_orient_matrix_UB_32 -0.0106723000 _diffrn_orient_matrix_UB_33 -0.0574768000 _diffrn_radiation_monochromator graphite _diffrn_radiation_probe x-ray _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54184 _diffrn_source 'Enhance (Cu) X-ray Source' _reflns_Friedel_coverage 0.000 _reflns_Friedel_fraction_full . _reflns_Friedel_fraction_max . _reflns_number_gt 3531 _reflns_number_total 4590 _reflns_odcompleteness_completeness 99.96 _reflns_odcompleteness_iscentric 1 _reflns_odcompleteness_theta 66.97 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_collection ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_reduction ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution 'ShelXS (Sheldrick, 2008)' _refine_diff_density_max 0.269 _refine_diff_density_min -0.450 _refine_diff_density_rms 0.058 _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.015 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 319 _refine_ls_number_reflns 4590 _refine_ls_number_restraints 0 _refine_ls_R_factor_all 0.0603 _refine_ls_R_factor_gt 0.0444 _refine_ls_restrained_S_all 1.015 _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0616P)^2^+0.5371P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1123 _refine_ls_wR_factor_ref 0.1261 _refine_special_details ? _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups At 1.5 times of: All C(H,H,H) groups 2.a Ternary CH refined with riding coordinates: C7(H7), C8(H8), C9(H9) 2.b Secondary CH2 refined with riding coordinates: C10(H10A,H10B), C20(H20A,H20B), C22(H22A,H22B) 2.c Aromatic/amide H refined with riding coordinates: C1(H1), C2(H2), C3(H3), C4(H4), C12(H12), C13(H13), C14(H14), C15(H15), C16(H16), C26(H26), C27(H27), C29(H29), C30(H30) 2.d Idealised Me refined as rotating group: C23(H23A,H23B,H23C), C24(H24A,H24B,H24C), C31(H31A,H31B,H31C) ; _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group Br1 Br -0.04757(2) -0.01860(4) 0.37544(2) 0.06148(16) Uani 1 1 d . . . . . C1 C 0.0167(2) 0.1485(3) 0.2134(2) 0.0582(9) Uani 1 1 d . . . . . H1 H -0.0273 0.1965 0.2394 0.070 Uiso 1 1 calc R . . . . C2 C 0.0205(3) 0.1495(4) 0.1293(2) 0.0659(10) Uani 1 1 d . . . . . H2 H -0.0220 0.1952 0.0988 0.079 Uiso 1 1 calc R . . . . C3 C 0.0885(2) 0.0815(3) 0.0911(2) 0.0572(9) Uani 1 1 d . . . . . H3 H 0.0919 0.0820 0.0345 0.069 Uiso 1 1 calc R . . . . C4 C 0.1509(2) 0.0133(3) 0.1365(2) 0.0468(7) Uani 1 1 d . . . . . H4 H 0.1970 -0.0304 0.1103 0.056 Uiso 1 1 calc R . . . . C5 C 0.14571(19) 0.0089(3) 0.22141(18) 0.0389(6) Uani 1 1 d . . . . . C6 C 0.07751(19) 0.0770(3) 0.25988(19) 0.0433(7) Uani 1 1 d . . . . . C7 C 0.06853(18) 0.0706(3) 0.35069(19) 0.0429(7) Uani 1 1 d . . . . . H7 H 0.0648 0.1547 0.3724 0.051 Uiso 1 1 calc R . . . . C8 C 0.14755(19) 0.0017(3) 0.39456(18) 0.0387(6) Uani 1 1 d . . . . . H8 H 0.1255 -0.0259 0.4477 0.046 Uiso 1 1 calc R . . . . C9 C 0.21534(18) -0.0645(3) 0.27126(17) 0.0379(6) Uani 1 1 d . . . . . H9 H 0.2342 -0.1372 0.2400 0.046 Uiso 1 1 calc R . . . . C10 C 0.2308(2) -0.1942(3) 0.39255(19) 0.0465(7) Uani 1 1 d . . . . . H10A H 0.2878 -0.1537 0.4089 0.056 Uiso 1 1 calc R . . . . H10B H 0.2463 -0.2621 0.3567 0.056 Uiso 1 1 calc R . . . . C11 C 0.1842(2) -0.2452(3) 0.46757(18) 0.0431(7) Uani 1 1 d . . . . . C12 C 0.2328(2) -0.2509(3) 0.5408(2) 0.0529(8) Uani 1 1 d . . . . . H12 H 0.2932 -0.2218 0.5438 0.063 Uiso 1 1 calc R . . . . C13 C 0.1926(3) -0.2993(4) 0.6094(2) 0.0658(10) Uani 1 1 d . . . . . H13 H 0.2264 -0.3035 0.6579 0.079 Uiso 1 1 calc R . . . . C14 C 0.1041(3) -0.3410(3) 0.6068(2) 0.0627(10) Uani 1 1 d . . . . . H14 H 0.0773 -0.3722 0.6537 0.075 Uiso 1 1 calc R . . . . C15 C 0.0541(2) -0.3370(3) 0.5350(2) 0.0593(9) Uani 1 1 d . . . . . H15 H -0.0061 -0.3667 0.5328 0.071 Uiso 1 1 calc R . . . . C16 C 0.0942(2) -0.2882(3) 0.4653(2) 0.0532(8) Uani 1 1 d . . . . . H16 H 0.0602 -0.2845 0.4169 0.064 Uiso 1 1 calc R . . . . C17 C 0.3757(2) 0.0158(3) 0.23299(18) 0.0443(7) Uani 1 1 d . . . . . C18 C 0.29941(19) 0.0150(3) 0.28901(17) 0.0379(6) Uani 1 1 d . . . . . C19 C 0.30071(18) 0.0868(3) 0.35691(17) 0.0371(6) Uani 1 1 d . . . . . C20 C 0.38062(19) 0.1692(3) 0.37915(18) 0.0441(7) Uani 1 1 d . . . . . H20A H 0.3909 0.1652 0.4376 0.053 Uiso 1 1 calc R . . . . H20B H 0.3643 0.2537 0.3656 0.053 Uiso 1 1 calc R . . . . C21 C 0.47084(19) 0.1367(3) 0.33685(18) 0.0451(7) Uani 1 1 d . . . . . C22 C 0.4486(2) 0.1124(3) 0.24721(18) 0.0499(8) Uani 1 1 d . . . . . H22A H 0.4284 0.1890 0.2221 0.060 Uiso 1 1 calc R . . . . H22B H 0.5047 0.0866 0.2204 0.060 Uiso 1 1 calc R . . . . C23 C 0.5155(3) 0.0230(4) 0.3754(3) 0.0699(11) Uani 1 1 d . . . . . H23A H 0.4731 -0.0451 0.3727 0.105 Uiso 1 1 calc GR . . . . H23B H 0.5310 0.0401 0.4314 0.105 Uiso 1 1 calc GR . . . . H23C H 0.5705 0.0023 0.3466 0.105 Uiso 1 1 calc GR . . . . C24 C 0.5361(2) 0.2485(4) 0.3442(2) 0.0673(11) Uani 1 1 d . . . . . H24A H 0.5934 0.2297 0.3184 0.101 Uiso 1 1 calc GR . . . . H24B H 0.5474 0.2668 0.4007 0.101 Uiso 1 1 calc GR . . . . H24C H 0.5081 0.3188 0.3180 0.101 Uiso 1 1 calc GR . . . . C25 C 0.22780(18) 0.1601(3) 0.48138(16) 0.0373(6) Uani 1 1 d . . . . . C26 C 0.2034(2) 0.2837(3) 0.47661(17) 0.0433(7) Uani 1 1 d . . . . . H26 H 0.1829 0.3173 0.4274 0.052 Uiso 1 1 calc R . . . . C27 C 0.2097(2) 0.3566(3) 0.54552(19) 0.0486(7) Uani 1 1 d . . . . . H27 H 0.1938 0.4397 0.5418 0.058 Uiso 1 1 calc R . . . . C28 C 0.2391(2) 0.3099(3) 0.61995(18) 0.0452(7) Uani 1 1 d . . . . . C29 C 0.2601(2) 0.1848(3) 0.62389(18) 0.0496(8) Uani 1 1 d . . . . . H29 H 0.2781 0.1502 0.6735 0.060 Uiso 1 1 calc R . . . . C30 C 0.2546(2) 0.1108(3) 0.55546(18) 0.0467(7) Uani 1 1 d . . . . . H30 H 0.2691 0.0273 0.5594 0.056 Uiso 1 1 calc R . . . . C31 C 0.2489(3) 0.3919(4) 0.6939(2) 0.0652(10) Uani 1 1 d . . . . . H31A H 0.1897 0.4255 0.7072 0.098 Uiso 1 1 calc GR . . . . H31B H 0.2909 0.4581 0.6824 0.098 Uiso 1 1 calc GR . . . . H31C H 0.2723 0.3444 0.7390 0.098 Uiso 1 1 calc GR . . . . N1 N 0.17235(16) -0.1058(2) 0.34771(14) 0.0388(5) Uani 1 1 d . . . . . N2 N 0.22716(15) 0.0859(2) 0.40841(14) 0.0400(6) Uani 1 1 d . . . . . O1 O 0.37940(16) -0.0556(3) 0.17501(14) 0.0657(7) Uani 1 1 d . . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 Br1 0.03193(19) 0.0869(3) 0.0658(3) -0.0033(2) 0.00724(15) -0.00322(17) C1 0.0434(17) 0.063(2) 0.068(2) 0.0006(19) -0.0036(15) 0.0080(16) C2 0.058(2) 0.070(2) 0.069(2) 0.017(2) -0.0140(18) 0.0060(19) C3 0.065(2) 0.063(2) 0.0436(18) 0.0087(17) -0.0083(16) -0.0128(19) C4 0.0476(17) 0.0494(18) 0.0435(17) -0.0015(14) 0.0027(13) -0.0079(14) C5 0.0324(14) 0.0415(16) 0.0428(16) -0.0016(13) -0.0015(11) -0.0056(12) C6 0.0325(14) 0.0458(17) 0.0516(17) -0.0049(15) -0.0011(12) -0.0003(13) C7 0.0291(13) 0.0471(17) 0.0524(17) -0.0087(15) 0.0022(12) -0.0008(13) C8 0.0303(13) 0.0479(17) 0.0379(15) -0.0031(13) 0.0048(11) 0.0000(12) C9 0.0340(13) 0.0418(15) 0.0381(15) -0.0068(13) 0.0022(11) 0.0018(12) C10 0.0368(15) 0.0513(18) 0.0514(18) 0.0043(15) 0.0049(13) 0.0079(14) C11 0.0431(16) 0.0427(17) 0.0437(16) 0.0002(14) 0.0033(12) 0.0031(13) C12 0.0554(19) 0.0498(19) 0.0532(19) 0.0019(16) -0.0086(15) 0.0005(16) C13 0.098(3) 0.056(2) 0.0425(18) 0.0034(17) -0.0086(18) 0.003(2) C14 0.084(3) 0.051(2) 0.054(2) 0.0035(17) 0.0222(19) 0.009(2) C15 0.0508(19) 0.057(2) 0.070(2) -0.0015(19) 0.0179(17) 0.0008(17) C16 0.0469(17) 0.067(2) 0.0459(17) -0.0029(17) 0.0002(13) 0.0013(16) C17 0.0333(14) 0.061(2) 0.0382(16) -0.0024(15) 0.0031(12) 0.0049(14) C18 0.0295(13) 0.0479(17) 0.0362(15) -0.0024(13) 0.0019(11) 0.0033(12) C19 0.0286(13) 0.0438(16) 0.0387(15) -0.0012(13) 0.0006(11) 0.0057(12) C20 0.0337(14) 0.0560(19) 0.0427(16) -0.0055(15) -0.0009(12) 0.0014(14) C21 0.0325(14) 0.060(2) 0.0424(16) -0.0042(15) 0.0000(12) 0.0011(14) C22 0.0364(15) 0.069(2) 0.0449(17) -0.0034(16) 0.0089(13) -0.0003(15) C23 0.051(2) 0.087(3) 0.071(3) 0.006(2) -0.0075(18) 0.020(2) C24 0.0358(17) 0.092(3) 0.075(2) -0.017(2) 0.0039(16) -0.0143(18) C25 0.0290(12) 0.0475(17) 0.0354(14) -0.0046(13) 0.0056(10) 0.0005(12) C26 0.0456(16) 0.0495(17) 0.0348(15) 0.0022(14) -0.0006(12) 0.0085(14) C27 0.0575(19) 0.0432(17) 0.0451(17) -0.0023(14) 0.0016(14) 0.0112(15) C28 0.0438(16) 0.0536(19) 0.0382(15) -0.0067(14) 0.0029(12) 0.0026(14) C29 0.0556(18) 0.059(2) 0.0342(15) 0.0022(15) -0.0040(13) 0.0076(16) C30 0.0490(17) 0.0434(17) 0.0475(18) 0.0012(14) -0.0003(13) 0.0093(14) C31 0.086(3) 0.067(2) 0.0425(18) -0.0088(18) -0.0042(17) 0.011(2) N1 0.0364(12) 0.0421(13) 0.0380(12) -0.0011(11) 0.0046(9) 0.0020(11) N2 0.0322(11) 0.0493(14) 0.0384(13) -0.0075(11) 0.0028(9) 0.0006(11) O1 0.0511(13) 0.0952(19) 0.0514(14) -0.0307(14) 0.0170(11) -0.0104(13) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag Br1 C7 1.986(3) . ? C1 H1 0.9300 . ? C1 C2 1.382(5) . ? C1 C6 1.392(4) . ? C2 H2 0.9300 . ? C2 C3 1.387(5) . ? C3 H3 0.9300 . ? C3 C4 1.378(5) . ? C4 H4 0.9300 . ? C4 C5 1.398(4) . ? C5 C6 1.391(4) . ? C5 C9 1.514(4) . ? C6 C7 1.500(4) . ? C7 H7 0.9800 . ? C7 C8 1.536(4) . ? C8 H8 0.9800 . ? C8 N1 1.443(4) . ? C8 N2 1.484(4) . ? C9 H9 0.9800 . ? C9 C18 1.516(4) . ? C9 N1 1.478(3) . ? C10 H10A 0.9700 . ? C10 H10B 0.9700 . ? C10 C11 1.517(4) . ? C10 N1 1.468(4) . ? C11 C12 1.386(4) . ? C11 C16 1.384(4) . ? C12 H12 0.9300 . ? C12 C13 1.378(5) . ? C13 H13 0.9300 . ? C13 C14 1.360(6) . ? C14 H14 0.9300 . ? C14 C15 1.375(5) . ? C15 H15 0.9300 . ? C15 C16 1.394(5) . ? C16 H16 0.9300 . ? C17 C18 1.448(4) . ? C17 C22 1.502(4) . ? C17 O1 1.228(4) . ? C18 C19 1.359(4) . ? C19 C20 1.502(4) . ? C19 N2 1.370(3) . ? C20 H20A 0.9700 . ? C20 H20B 0.9700 . ? C20 C21 1.530(4) . ? C21 C22 1.524(4) . ? C21 C23 1.524(5) . ? C21 C24 1.539(5) . ? C22 H22A 0.9700 . ? C22 H22B 0.9700 . ? C23 H23A 0.9600 . ? C23 H23B 0.9600 . ? C23 H23C 0.9600 . ? C24 H24A 0.9600 . ? C24 H24B 0.9600 . ? C24 H24C 0.9600 . ? C25 C26 1.386(4) . ? C25 C30 1.379(4) . ? C25 N2 1.442(4) . ? C26 H26 0.9300 . ? C26 C27 1.381(4) . ? C27 H27 0.9300 . ? C27 C28 1.383(4) . ? C28 C29 1.389(5) . ? C28 C31 1.509(4) . ? C29 H29 0.9300 . ? C29 C30 1.381(4) . ? C30 H30 0.9300 . ? C31 H31A 0.9600 . ? C31 H31B 0.9600 . ? C31 H31C 0.9600 . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C2 C1 H1 119.4 . . ? C2 C1 C6 121.1(3) . . ? C6 C1 H1 119.4 . . ? C1 C2 H2 120.4 . . ? C1 C2 C3 119.2(3) . . ? C3 C2 H2 120.4 . . ? C2 C3 H3 119.9 . . ? C4 C3 C2 120.2(3) . . ? C4 C3 H3 119.9 . . ? C3 C4 H4 119.5 . . ? C3 C4 C5 120.9(3) . . ? C5 C4 H4 119.5 . . ? C4 C5 C9 120.8(3) . . ? C6 C5 C4 118.9(3) . . ? C6 C5 C9 120.3(3) . . ? C1 C6 C7 120.4(3) . . ? C5 C6 C1 119.6(3) . . ? C5 C6 C7 120.0(3) . . ? Br1 C7 H7 109.0 . . ? C6 C7 Br1 108.2(2) . . ? C6 C7 H7 109.0 . . ? C6 C7 C8 114.4(2) . . ? C8 C7 Br1 107.2(2) . . ? C8 C7 H7 109.0 . . ? C7 C8 H8 108.3 . . ? N1 C8 C7 109.3(2) . . ? N1 C8 H8 108.3 . . ? N1 C8 N2 112.2(2) . . ? N2 C8 C7 110.2(2) . . ? N2 C8 H8 108.3 . . ? C5 C9 H9 109.1 . . ? C5 C9 C18 109.4(2) . . ? C18 C9 H9 109.1 . . ? N1 C9 C5 109.3(2) . . ? N1 C9 H9 109.1 . . ? N1 C9 C18 110.8(2) . . ? H10A C10 H10B 107.8 . . ? C11 C10 H10A 109.1 . . ? C11 C10 H10B 109.1 . . ? N1 C10 H10A 109.1 . . ? N1 C10 H10B 109.1 . . ? N1 C10 C11 112.6(2) . . ? C12 C11 C10 119.6(3) . . ? C16 C11 C10 122.1(3) . . ? C16 C11 C12 118.3(3) . . ? C11 C12 H12 119.7 . . ? C13 C12 C11 120.6(3) . . ? C13 C12 H12 119.7 . . ? C12 C13 H13 119.6 . . ? C14 C13 C12 120.8(4) . . ? C14 C13 H13 119.6 . . ? C13 C14 H14 120.0 . . ? C13 C14 C15 120.0(3) . . ? C15 C14 H14 120.0 . . ? C14 C15 H15 120.2 . . ? C14 C15 C16 119.7(3) . . ? C16 C15 H15 120.2 . . ? C11 C16 C15 120.6(3) . . ? C11 C16 H16 119.7 . . ? C15 C16 H16 119.7 . . ? C18 C17 C22 116.6(3) . . ? O1 C17 C18 122.1(3) . . ? O1 C17 C22 121.3(3) . . ? C17 C18 C9 120.0(2) . . ? C19 C18 C9 118.9(2) . . ? C19 C18 C17 121.1(3) . . ? C18 C19 C20 122.7(2) . . ? C18 C19 N2 120.1(3) . . ? N2 C19 C20 117.3(2) . . ? C19 C20 H20A 108.6 . . ? C19 C20 H20B 108.6 . . ? C19 C20 C21 114.4(2) . . ? H20A C20 H20B 107.6 . . ? C21 C20 H20A 108.6 . . ? C21 C20 H20B 108.6 . . ? C20 C21 C24 108.2(3) . . ? C22 C21 C20 108.0(2) . . ? C22 C21 C24 109.4(3) . . ? C23 C21 C20 110.9(3) . . ? C23 C21 C22 110.1(3) . . ? C23 C21 C24 110.3(3) . . ? C17 C22 C21 114.1(3) . . ? C17 C22 H22A 108.7 . . ? C17 C22 H22B 108.7 . . ? C21 C22 H22A 108.7 . . ? C21 C22 H22B 108.7 . . ? H22A C22 H22B 107.6 . . ? C21 C23 H23A 109.5 . . ? C21 C23 H23B 109.5 . . ? C21 C23 H23C 109.5 . . ? H23A C23 H23B 109.5 . . ? H23A C23 H23C 109.5 . . ? H23B C23 H23C 109.5 . . ? C21 C24 H24A 109.5 . . ? C21 C24 H24B 109.5 . . ? C21 C24 H24C 109.5 . . ? H24A C24 H24B 109.5 . . ? H24A C24 H24C 109.5 . . ? H24B C24 H24C 109.5 . . ? C26 C25 N2 119.5(3) . . ? C30 C25 C26 119.5(3) . . ? C30 C25 N2 121.0(3) . . ? C25 C26 H26 120.3 . . ? C27 C26 C25 119.5(3) . . ? C27 C26 H26 120.3 . . ? C26 C27 H27 119.0 . . ? C26 C27 C28 122.0(3) . . ? C28 C27 H27 119.0 . . ? C27 C28 C29 117.5(3) . . ? C27 C28 C31 121.2(3) . . ? C29 C28 C31 121.2(3) . . ? C28 C29 H29 119.4 . . ? C30 C29 C28 121.2(3) . . ? C30 C29 H29 119.4 . . ? C25 C30 C29 120.3(3) . . ? C25 C30 H30 119.8 . . ? C29 C30 H30 119.8 . . ? C28 C31 H31A 109.5 . . ? C28 C31 H31B 109.5 . . ? C28 C31 H31C 109.5 . . ? H31A C31 H31B 109.5 . . ? H31A C31 H31C 109.5 . . ? H31B C31 H31C 109.5 . . ? C8 N1 C9 108.7(2) . . ? C8 N1 C10 113.9(2) . . ? C10 N1 C9 112.0(2) . . ? C19 N2 C8 121.3(2) . . ? C19 N2 C25 120.9(2) . . ? C25 N2 C8 117.7(2) . . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag Br1 C7 C8 N1 79.6(2) . . . . ? Br1 C7 C8 N2 -156.63(18) . . . . ? C1 C2 C3 C4 0.4(6) . . . . ? C1 C6 C7 Br1 68.0(3) . . . . ? C1 C6 C7 C8 -172.6(3) . . . . ? C2 C1 C6 C5 2.5(5) . . . . ? C2 C1 C6 C7 -176.1(3) . . . . ? C2 C3 C4 C5 1.5(5) . . . . ? C3 C4 C5 C6 -1.4(5) . . . . ? C3 C4 C5 C9 -179.0(3) . . . . ? C4 C5 C6 C1 -0.6(4) . . . . ? C4 C5 C6 C7 178.0(3) . . . . ? C4 C5 C9 C18 86.3(3) . . . . ? C4 C5 C9 N1 -152.2(3) . . . . ? C5 C6 C7 Br1 -110.5(3) . . . . ? C5 C6 C7 C8 8.9(4) . . . . ? C5 C9 C18 C17 -89.7(3) . . . . ? C5 C9 C18 C19 88.8(3) . . . . ? C5 C9 N1 C8 -62.7(3) . . . . ? C5 C9 N1 C10 170.6(2) . . . . ? C6 C1 C2 C3 -2.4(6) . . . . ? C6 C5 C9 C18 -91.3(3) . . . . ? C6 C5 C9 N1 30.3(4) . . . . ? C6 C7 C8 N1 -40.3(3) . . . . ? C6 C7 C8 N2 83.4(3) . . . . ? C7 C8 N1 C9 68.3(3) . . . . ? C7 C8 N1 C10 -166.0(2) . . . . ? C7 C8 N2 C19 -97.8(3) . . . . ? C7 C8 N2 C25 86.8(3) . . . . ? C9 C5 C6 C1 177.0(3) . . . . ? C9 C5 C6 C7 -4.4(4) . . . . ? C9 C18 C19 C20 -179.6(3) . . . . ? C9 C18 C19 N2 0.5(4) . . . . ? C10 C11 C12 C13 -178.6(3) . . . . ? C10 C11 C16 C15 178.6(3) . . . . ? C11 C10 N1 C8 60.8(3) . . . . ? C11 C10 N1 C9 -175.3(2) . . . . ? C11 C12 C13 C14 -0.8(6) . . . . ? C12 C11 C16 C15 -0.6(5) . . . . ? C12 C13 C14 C15 1.0(6) . . . . ? C13 C14 C15 C16 -1.1(6) . . . . ? C14 C15 C16 C11 0.9(6) . . . . ? C16 C11 C12 C13 0.6(5) . . . . ? C17 C18 C19 C20 -1.1(5) . . . . ? C17 C18 C19 N2 179.0(3) . . . . ? C18 C9 N1 C8 58.0(3) . . . . ? C18 C9 N1 C10 -68.7(3) . . . . ? C18 C17 C22 C21 38.1(4) . . . . ? C18 C19 C20 C21 -18.7(4) . . . . ? C18 C19 N2 C8 3.8(4) . . . . ? C18 C19 N2 C25 179.1(3) . . . . ? C19 C20 C21 C22 44.7(4) . . . . ? C19 C20 C21 C23 -76.0(3) . . . . ? C19 C20 C21 C24 162.9(3) . . . . ? C20 C19 N2 C8 -176.1(3) . . . . ? C20 C19 N2 C25 -0.8(4) . . . . ? C20 C21 C22 C17 -54.9(4) . . . . ? C22 C17 C18 C9 169.9(3) . . . . ? C22 C17 C18 C19 -8.6(4) . . . . ? C23 C21 C22 C17 66.3(4) . . . . ? C24 C21 C22 C17 -172.4(3) . . . . ? C25 C26 C27 C28 -0.6(5) . . . . ? C26 C25 C30 C29 -2.1(4) . . . . ? C26 C25 N2 C8 -101.9(3) . . . . ? C26 C25 N2 C19 82.7(3) . . . . ? C26 C27 C28 C29 -1.6(5) . . . . ? C26 C27 C28 C31 177.7(3) . . . . ? C27 C28 C29 C30 2.0(5) . . . . ? C28 C29 C30 C25 -0.1(5) . . . . ? C30 C25 C26 C27 2.5(4) . . . . ? C30 C25 N2 C8 79.8(3) . . . . ? C30 C25 N2 C19 -95.6(3) . . . . ? C31 C28 C29 C30 -177.4(3) . . . . ? N1 C8 N2 C19 24.3(4) . . . . ? N1 C8 N2 C25 -151.1(2) . . . . ? N1 C9 C18 C17 149.6(3) . . . . ? N1 C9 C18 C19 -31.9(4) . . . . ? N1 C10 C11 C12 -133.8(3) . . . . ? N1 C10 C11 C16 47.0(4) . . . . ? N2 C8 N1 C9 -54.2(3) . . . . ? N2 C8 N1 C10 71.4(3) . . . . ? N2 C19 C20 C21 161.2(3) . . . . ? N2 C25 C26 C27 -175.9(3) . . . . ? N2 C25 C30 C29 176.2(3) . . . . ? O1 C17 C18 C9 -7.6(5) . . . . ? O1 C17 C18 C19 173.9(3) . . . . ? O1 C17 C22 C21 -144.3(3) . . . . ? _iucr_refine_instructions_details ; 20190484.res created by SHELXL-2014/7 TITL 20190484 in P21/n #14 REM reset to P21/n #14 CELL 1.54184 14.485048 10.823856 16.41343 90 90.869 90 ZERR 4 0.00045 0.000535 0.000653 0 0.0031 0 LATT 1 SYMM 0.5-X,0.5+Y,0.5-Z SFAC C H Br N O UNIT 124 124 4 8 4 L.S. 9 0 0 PLAN 20 SIZE 0.1 0.13 0.17 MPLA C1 C2 C3 C4 C5 C6 C7 C8 C9 MPLA C8 C9 N1 MPLA C11 C12 C13 C14 C15 C16 MPLA C17 C18 C19 C20 C22 MPLA C20 C21 C22 MPLA C25 C26 C27 C28 C29 C30 bond $h conf fmap 2 acta REM REM REM WGHT 0.061600 0.537100 FVAR 4.85720 BR1 3 -0.047574 -0.018605 0.375438 11.00000 0.03193 0.08687 = 0.06585 -0.00330 0.00724 -0.00322 C1 1 0.016671 0.148547 0.213411 11.00000 0.04338 0.06258 = 0.06845 0.00060 -0.00357 0.00800 AFIX 43 H1 2 -0.027286 0.196503 0.239391 11.00000 -1.20000 AFIX 0 C2 1 0.020492 0.149545 0.129334 11.00000 0.05845 0.07001 = 0.06888 0.01744 -0.01405 0.00605 AFIX 43 H2 2 -0.021971 0.195245 0.098795 11.00000 -1.20000 AFIX 0 C3 1 0.088451 0.081537 0.091056 11.00000 0.06510 0.06275 = 0.04362 0.00872 -0.00832 -0.01277 AFIX 43 H3 2 0.091900 0.082000 0.034524 11.00000 -1.20000 AFIX 0 C4 1 0.150858 0.013305 0.136495 11.00000 0.04755 0.04941 = 0.04347 -0.00146 0.00265 -0.00788 AFIX 43 H4 2 0.197042 -0.030407 0.110305 11.00000 -1.20000 AFIX 0 C5 1 0.145708 0.008879 0.221415 11.00000 0.03237 0.04152 = 0.04276 -0.00155 -0.00149 -0.00565 C6 1 0.077513 0.076963 0.259875 11.00000 0.03251 0.04581 = 0.05156 -0.00486 -0.00107 -0.00029 C7 1 0.068530 0.070594 0.350692 11.00000 0.02915 0.04711 = 0.05242 -0.00870 0.00218 -0.00080 AFIX 13 H7 2 0.064771 0.154738 0.372435 11.00000 -1.20000 AFIX 0 C8 1 0.147554 0.001745 0.394561 11.00000 0.03032 0.04793 = 0.03788 -0.00307 0.00484 -0.00002 AFIX 13 H8 2 0.125486 -0.025945 0.447672 11.00000 -1.20000 AFIX 0 C9 1 0.215340 -0.064547 0.271265 11.00000 0.03396 0.04183 = 0.03810 -0.00680 0.00224 0.00178 AFIX 13 H9 2 0.234195 -0.137186 0.239996 11.00000 -1.20000 AFIX 0 C10 1 0.230758 -0.194191 0.392545 11.00000 0.03681 0.05130 = 0.05144 0.00429 0.00488 0.00793 AFIX 23 H10A 2 0.287825 -0.153707 0.408932 11.00000 -1.20000 H10B 2 0.246275 -0.262075 0.356682 11.00000 -1.20000 AFIX 0 C11 1 0.184215 -0.245218 0.467572 11.00000 0.04306 0.04271 = 0.04375 0.00020 0.00329 0.00311 C12 1 0.232850 -0.250930 0.540823 11.00000 0.05539 0.04980 = 0.05320 0.00191 -0.00856 0.00049 AFIX 43 H12 2 0.293221 -0.221839 0.543764 11.00000 -1.20000 AFIX 0 C13 1 0.192612 -0.299311 0.609367 11.00000 0.09828 0.05617 = 0.04253 0.00336 -0.00860 0.00284 AFIX 43 H13 2 0.226417 -0.303470 0.657915 11.00000 -1.20000 AFIX 0 C14 1 0.104087 -0.341025 0.606847 11.00000 0.08407 0.05091 = 0.05364 0.00354 0.02216 0.00946 AFIX 43 H14 2 0.077330 -0.372248 0.653702 11.00000 -1.20000 AFIX 0 C15 1 0.054117 -0.337027 0.534973 11.00000 0.05080 0.05726 = 0.07041 -0.00149 0.01785 0.00075 AFIX 43 H15 2 -0.006113 -0.366743 0.532843 11.00000 -1.20000 AFIX 0 C16 1 0.094206 -0.288213 0.465345 11.00000 0.04689 0.06691 = 0.04589 -0.00291 0.00023 0.00130 AFIX 43 H16 2 0.060154 -0.284490 0.416915 11.00000 -1.20000 AFIX 0 C17 1 0.375653 0.015810 0.232991 11.00000 0.03331 0.06150 = 0.03824 -0.00236 0.00310 0.00491 C18 1 0.299410 0.014982 0.289006 11.00000 0.02954 0.04792 = 0.03617 -0.00236 0.00189 0.00326 C19 1 0.300706 0.086835 0.356907 11.00000 0.02864 0.04378 = 0.03874 -0.00121 0.00059 0.00574 C20 1 0.380618 0.169209 0.379146 11.00000 0.03373 0.05598 = 0.04268 -0.00552 -0.00091 0.00143 AFIX 23 H20A 2 0.390863 0.165202 0.437625 11.00000 -1.20000 H20B 2 0.364281 0.253733 0.365593 11.00000 -1.20000 AFIX 0 C21 1 0.470845 0.136729 0.336852 11.00000 0.03248 0.06023 = 0.04243 -0.00423 -0.00004 0.00113 C22 1 0.448623 0.112390 0.247211 11.00000 0.03638 0.06864 = 0.04494 -0.00337 0.00887 -0.00031 AFIX 23 H22A 2 0.428355 0.189019 0.222058 11.00000 -1.20000 H22B 2 0.504668 0.086618 0.220431 11.00000 -1.20000 AFIX 0 C23 1 0.515485 0.022974 0.375447 11.00000 0.05108 0.08703 = 0.07120 0.00624 -0.00750 0.02047 AFIX 137 H23A 2 0.473073 -0.045104 0.372690 11.00000 -1.50000 H23B 2 0.530983 0.040080 0.431392 11.00000 -1.50000 H23C 2 0.570515 0.002297 0.346570 11.00000 -1.50000 AFIX 0 C24 1 0.536067 0.248507 0.344177 11.00000 0.03583 0.09152 = 0.07479 -0.01699 0.00390 -0.01432 AFIX 137 H24A 2 0.593444 0.229680 0.318423 11.00000 -1.50000 H24B 2 0.547355 0.266832 0.400681 11.00000 -1.50000 H24C 2 0.508097 0.318752 0.317996 11.00000 -1.50000 AFIX 0 C25 1 0.227803 0.160139 0.481375 11.00000 0.02902 0.04753 = 0.03537 -0.00465 0.00564 0.00046 C26 1 0.203401 0.283726 0.476610 11.00000 0.04560 0.04952 = 0.03481 0.00219 -0.00058 0.00850 AFIX 43 H26 2 0.182929 0.317311 0.427411 11.00000 -1.20000 AFIX 0 C27 1 0.209729 0.356633 0.545525 11.00000 0.05755 0.04321 = 0.04513 -0.00233 0.00161 0.01123 AFIX 43 H27 2 0.193775 0.439688 0.541783 11.00000 -1.20000 AFIX 0 C28 1 0.239083 0.309851 0.619949 11.00000 0.04378 0.05356 = 0.03818 -0.00675 0.00289 0.00256 C29 1 0.260068 0.184760 0.623889 11.00000 0.05564 0.05896 = 0.03415 0.00219 -0.00396 0.00757 AFIX 43 H29 2 0.278120 0.150220 0.673506 11.00000 -1.20000 AFIX 0 C30 1 0.254608 0.110779 0.555460 11.00000 0.04904 0.04344 = 0.04753 0.00117 -0.00026 0.00934 AFIX 43 H30 2 0.269081 0.027258 0.559363 11.00000 -1.20000 AFIX 0 C31 1 0.248887 0.391928 0.693873 11.00000 0.08579 0.06703 = 0.04252 -0.00885 -0.00417 0.01051 AFIX 137 H31A 2 0.189682 0.425533 0.707237 11.00000 -1.50000 H31B 2 0.290888 0.458064 0.682387 11.00000 -1.50000 H31C 2 0.272330 0.344410 0.739032 11.00000 -1.50000 AFIX 0 N1 4 0.172349 -0.105767 0.347706 11.00000 0.03643 0.04207 = 0.03801 -0.00112 0.00465 0.00204 N2 4 0.227159 0.085928 0.408414 11.00000 0.03220 0.04931 = 0.03845 -0.00748 0.00284 0.00056 O1 5 0.379400 -0.055597 0.175007 11.00000 0.05106 0.09516 = 0.05143 -0.03069 0.01701 -0.01037 HKLF 4 REM 20190484 in P21/n #14 REM R1 = 0.0444 for 3531 Fo > 4sig(Fo) and 0.0603 for all 4590 data REM 319 parameters refined using 0 restraints END WGHT 0.0616 0.5371 REM Highest difference peak 0.269, deepest hole -0.450, 1-sigma level 0.058 Q1 1 0.1781 -0.0206 0.2476 11.00000 0.05 0.27 Q2 1 0.2243 0.4636 0.6788 11.00000 0.05 0.23 Q3 1 0.3333 0.0143 0.2632 11.00000 0.05 0.23 Q4 1 0.2201 0.3231 0.7551 11.00000 0.05 0.22 Q5 1 0.3086 0.3877 0.7243 11.00000 0.05 0.21 Q6 1 0.1999 -0.2092 0.5010 11.00000 0.05 0.21 Q7 1 0.1327 0.0785 0.2419 11.00000 0.05 0.20 Q8 1 -0.0216 -0.0830 0.4085 11.00000 0.05 0.20 Q9 1 0.3159 0.0172 0.3328 11.00000 0.05 0.20 Q10 1 0.3547 0.5818 0.7135 11.00000 0.05 0.20 Q11 1 0.4756 0.0731 0.3583 11.00000 0.05 0.20 Q12 1 0.2024 -0.2220 0.4353 11.00000 0.05 0.20 Q13 1 -0.0633 0.1420 0.2541 11.00000 0.05 0.19 Q14 1 0.2750 0.0628 0.7387 11.00000 0.05 0.18 Q15 1 0.0842 -0.0068 0.0053 11.00000 0.05 0.18 Q16 1 0.2622 -0.0303 0.2857 11.00000 0.05 0.18 Q17 1 0.4227 0.1517 0.3498 11.00000 0.05 0.18 Q18 1 -0.0159 -0.1030 0.3519 11.00000 0.05 0.18 Q19 1 0.1877 0.2250 0.4867 11.00000 0.05 0.18 Q20 1 0.0979 0.0977 0.3092 11.00000 0.05 0.17 REM The information below was added by Olex2. REM REM R1 = 0.0444 for 3531 Fo > 4sig(Fo) and 0.0603 for all 10942 data REM n/a parameters refined using n/a restraints REM Highest difference peak 0.27, deepest hole -0.45 REM Mean Shift 0, Max Shift 0.001. REM +++ Tabular Listing of Refinement Information +++ REM R1_all = 0.0603 REM R1_gt = 0.0444 REM wR_ref = 0.1261 REM GOOF = 1.015 REM Shift_max = 0.001 REM Shift_mean = 0 REM Reflections_all = 10942 REM Reflections_gt = 3531 REM Parameters = n/a REM Hole = -0.45 REM Peak = 0.27 REM Flack = n/a ; _olex2_submission_special_instructions 'No special instructions were received' ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_201803150_tw _database_code_depnum_ccdc_archive 'CCDC 1944660' loop_ _audit_author_name _audit_author_address 'Qilin Wang' ;Henan University China ; _audit_update_record ; 2019-08-01 deposited with the CCDC. 2019-12-17 downloaded from the CCDC. ; _audit_creation_date 2018-03-05 _audit_creation_method ; Olex2 1.2 (compiled 2017.08.10 svn.r3458 for OlexSys, GUI svn.r5381) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic ? _chemical_formula_moiety 'C39 H39 N5 O5' _chemical_formula_sum 'C39 H39 N5 O5' _chemical_formula_weight 657.75 _chemical_melting_point ? _chemical_oxdiff_formula C40H30N3O5Br1 loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system monoclinic _space_group_IT_number 14 _space_group_name_H-M_alt 'P 1 21/c 1' _space_group_name_Hall '-P 2ybc' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y-1/2, z-1/2' _cell_length_a 11.80408(14) _cell_length_b 18.74504(18) _cell_length_c 31.2581(4) _cell_angle_alpha 90 _cell_angle_beta 79.1361(11) _cell_angle_gamma 90 _cell_volume 6792.46(13) _cell_formula_units_Z 8 _cell_measurement_reflns_used 13858 _cell_measurement_temperature 293(2) _cell_measurement_theta_max 70.6640 _cell_measurement_theta_min 3.7250 _shelx_estimated_absorpt_T_max 0.934 _shelx_estimated_absorpt_T_min 0.879 _exptl_absorpt_coefficient_mu 0.697 _exptl_absorpt_correction_T_max 1.00000 _exptl_absorpt_correction_T_min 0.84160 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. ; _exptl_absorpt_special_details ? _exptl_crystal_colour yellow _exptl_crystal_colour_primary yellow _exptl_crystal_density_diffrn 1.286 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description plate _exptl_crystal_F_000 2784 _exptl_crystal_size_max 0.19 _exptl_crystal_size_mid 0.17 _exptl_crystal_size_min 0.1 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents ? _diffrn_reflns_av_unetI/netI 0.0253 _diffrn_reflns_Laue_measured_fraction_full 0.995 _diffrn_reflns_Laue_measured_fraction_max 0.995 _diffrn_reflns_limit_h_max 14 _diffrn_reflns_limit_h_min -14 _diffrn_reflns_limit_k_max 22 _diffrn_reflns_limit_k_min -22 _diffrn_reflns_limit_l_max 37 _diffrn_reflns_limit_l_min -13 _diffrn_reflns_number 11515 _diffrn_reflns_point_group_measured_fraction_full 0.995 _diffrn_reflns_point_group_measured_fraction_max 0.995 _diffrn_reflns_theta_full 67.096 _diffrn_reflns_theta_max 67.096 _diffrn_reflns_theta_min 3.722 _diffrn_ambient_temperature 293(2) _diffrn_detector 'CCD plate' _diffrn_detector_area_resol_mean 16.2312 _diffrn_detector_type Eos _diffrn_measured_fraction_theta_full 0.995 _diffrn_measured_fraction_theta_max 0.995 _diffrn_measurement_details ; #__ type_ start__ end____ width___ exp.time_ 1 omega -74.00 -16.80 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 -19.0000 60.0000 143 #__ type_ start__ end____ width___ exp.time_ 2 omega -94.00 -62.80 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 90.0000 78 #__ type_ start__ end____ width___ exp.time_ 3 omega 24.00 50.00 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 77.0000 -60.0000 65 #__ type_ start__ end____ width___ exp.time_ 4 omega 2.00 37.20 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 90.0000 88 #__ type_ start__ end____ width___ exp.time_ 5 omega -6.00 68.00 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -97.0000 -153.0000 185 #__ type_ start__ end____ width___ exp.time_ 6 omega 0.00 26.00 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 19.0000 90.0000 65 #__ type_ start__ end____ width___ exp.time_ 7 omega 50.00 103.20 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 57.0000 -90.0000 133 #__ type_ start__ end____ width___ exp.time_ 8 omega -16.00 52.00 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -57.0000 90.0000 170 #__ type_ start__ end____ width___ exp.time_ 9 omega 61.00 93.00 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -150.0000 80 #__ type_ start__ end____ width___ exp.time_ 10 omega 45.00 74.20 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 90.0000 73 #__ type_ start__ end____ width___ exp.time_ 11 omega 46.00 72.00 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 19.0000 90.0000 65 #__ type_ start__ end____ width___ exp.time_ 12 omega 60.00 103.20 0.4000 16.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 77.0000 -60.0000 108 #__ type_ start__ end____ width___ exp.time_ 13 omega 74.00 100.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -97.0000 -153.0000 65 #__ type_ start__ end____ width___ exp.time_ 14 omega 100.80 178.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 45.0000 -60.0000 193 #__ type_ start__ end____ width___ exp.time_ 15 omega 46.00 85.20 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 30.0000 98 #__ type_ start__ end____ width___ exp.time_ 16 omega 38.00 113.20 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 -60.0000 188 #__ type_ start__ end____ width___ exp.time_ 17 omega 42.00 108.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 90.0000 165 #__ type_ start__ end____ width___ exp.time_ 18 omega 83.00 175.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 77.0000 -120.0000 230 #__ type_ start__ end____ width___ exp.time_ 19 omega 40.00 90.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 120.0000 125 #__ type_ start__ end____ width___ exp.time_ 20 omega 56.00 82.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 150.0000 65 #__ type_ start__ end____ width___ exp.time_ 21 omega 111.00 169.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 15.0000 -180.0000 145 #__ type_ start__ end____ width___ exp.time_ 22 omega 45.00 73.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 -180.0000 70 #__ type_ start__ end____ width___ exp.time_ 23 omega 68.00 94.00 0.4000 52.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 15.0000 -180.0000 65 ; _diffrn_measurement_device 'four-circle diffractometer' _diffrn_measurement_device_type 'Xcalibur, Eos, Gemini' _diffrn_measurement_method '\w scans' _diffrn_orient_matrix_UB_11 -0.1220333000 _diffrn_orient_matrix_UB_12 0.0177796000 _diffrn_orient_matrix_UB_13 -0.0076587000 _diffrn_orient_matrix_UB_21 0.0513503000 _diffrn_orient_matrix_UB_22 0.0252290000 _diffrn_orient_matrix_UB_23 -0.0465206000 _diffrn_orient_matrix_UB_31 -0.0115330000 _diffrn_orient_matrix_UB_32 -0.0761516000 _diffrn_orient_matrix_UB_33 -0.0172119000 _diffrn_radiation_monochromator graphite _diffrn_radiation_probe x-ray _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54184 _diffrn_source 'Enhance (Cu) X-ray Source' _reflns_Friedel_coverage 0.000 _reflns_Friedel_fraction_full . _reflns_Friedel_fraction_max . _reflns_number_gt 9893 _reflns_number_total 11515 _reflns_odcompleteness_completeness 94.43 _reflns_odcompleteness_iscentric 1 _reflns_odcompleteness_theta 66.97 _reflns_special_details ; _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_collection ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_reduction ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution 'SIR2004 (Burla et al., 2007)' _refine_diff_density_max 0.381 _refine_diff_density_min -0.274 _refine_diff_density_rms 0.041 _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.038 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 890 _refine_ls_number_reflns 11515 _refine_ls_number_restraints 44 _refine_ls_R_factor_all 0.0596 _refine_ls_R_factor_gt 0.0516 _refine_ls_restrained_S_all 1.056 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0903P)^2^+0.7126P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1400 _refine_ls_wR_factor_ref 0.1465 _refine_special_details ; Refined as a 2-component twin. ; _olex2_refinement_description ; 1. Twinned data refinement Scales: 0.6569(10) 0.3431(10) 2. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups At 1.5 times of: All C(H,H,H) groups 3. Rigid bond restraints C36', C37' with sigma for 1-2 distances of 0.001 and sigma for 1-3 distances of 0.001 C24, C25 with sigma for 1-2 distances of 0.001 and sigma for 1-3 distances of 0.001 4. Uiso/Uaniso restraints and constraints Uanis(C36') \\sim Ueq, Uanis(C37') \\sim Ueq, Uanis(C38') \\sim Ueq, Uanis(C39') \\sim Ueq: with sigma of 0.01 and sigma for terminal atoms of 0.02 Uanis(C24) \\sim Ueq, Uanis(C25) \\sim Ueq: with sigma of 0.01 and sigma for terminal atoms of 0.02 Uanis(C33') \\sim Ueq: with sigma of 0.01 and sigma for terminal atoms of 0.02 5.a Ternary CH refined with riding coordinates: C16(H16), C18(H18), C19(H19), C20(H20), C28(H28), C30(H30), C16'(H16'), C18'(H18'), C19'(H19'), C20'(H20'), C28'(H28'), C30'(H30') 5.b Secondary CH2 refined with riding coordinates: C2(H2A,H2B), C4(H4A,H4B), C21(H21A,H21B), C33(H33A,H33B), C2'(H2'A,H2'B), C4'(H4'A,H4'B), C21'(H21C,H21D), C33'(H33C,H33D) 5.c Aromatic/amide H refined with riding coordinates: C10(H10), C11(H11), C13(H13), C14(H14), C23(H23), C24(H24), C25(H25), C26(H26), C27(H27), C31(H31), C32(H32), C35(H35), C36(H36), C37(H37), C38(H38), C39(H39), C10'(H10'), C11'(H11'), C13'(H13'), C14'(H14'), C23'(H23'), C24'(H24'), C25'(H25'), C26'(H26'), C27'(H27'), C31'(H31'), C32'(H32'), C35'(H35'), C36'(H36'), C37'(H37'), C38'(H38'), C39'(H39') 5.d Idealised Me refined as rotating group: C7(H7A,H7B,H7C), C8(H8A,H8B,H8C), C15(H15A,H15B,H15C), C7'(H7'A,H7'B,H7'C), C8'(H8'A,H8'B,H8'C), C15'(H15D,H15E,H15F) ; _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C1 C 0.3358(2) 0.83578(13) 0.45512(8) 0.0477(5) Uani 1 1 d . . . . . C2 C 0.3112(3) 0.75714(14) 0.45657(8) 0.0580(7) Uani 1 1 d . . . . . H2A H 0.2297 0.7500 0.4567 0.070 Uiso 1 1 calc R . . . . H2B H 0.3275 0.7379 0.4836 0.070 Uiso 1 1 calc R . . . . C3 C 0.3809(3) 0.71575(14) 0.41858(9) 0.0567(7) Uani 1 1 d . . . . . C4 C 0.3596(3) 0.75061(13) 0.37664(8) 0.0542(6) Uani 1 1 d . . . . . H4A H 0.4129 0.7303 0.3522 0.065 Uiso 1 1 calc R . . . . H4B H 0.2821 0.7389 0.3729 0.065 Uiso 1 1 calc R . . . . C5 C 0.3732(2) 0.83036(12) 0.37536(7) 0.0428(5) Uani 1 1 d . . . . . C6 C 0.3679(2) 0.86930(12) 0.41277(7) 0.0415(5) Uani 1 1 d . . . . . C7 C 0.5086(3) 0.71839(19) 0.42136(11) 0.0738(9) Uani 1 1 d . . . . . H7A H 0.5522 0.6907 0.3981 0.111 Uiso 1 1 calc GR . . . . H7B H 0.5190 0.6992 0.4488 0.111 Uiso 1 1 calc GR . . . . H7C H 0.5348 0.7670 0.4189 0.111 Uiso 1 1 calc GR . . . . C8 C 0.3377(4) 0.63923(15) 0.41979(11) 0.0842(11) Uani 1 1 d . . . . . H8A H 0.2566 0.6391 0.4193 0.126 Uiso 1 1 calc GR . . . . H8B H 0.3509 0.6165 0.4459 0.126 Uiso 1 1 calc GR . . . . H8C H 0.3783 0.6139 0.3949 0.126 Uiso 1 1 calc GR . . . . C9 C 0.3821(2) 0.82946(13) 0.29595(8) 0.0459(5) Uani 1 1 d . . . . . C10 C 0.2775(3) 0.79860(15) 0.29218(10) 0.0577(6) Uani 1 1 d . . . . . H10 H 0.2171 0.7981 0.3160 0.069 Uiso 1 1 calc R . . . . C11 C 0.2629(3) 0.76909(15) 0.25380(10) 0.0664(8) Uani 1 1 d . . . . . H11 H 0.1929 0.7476 0.2521 0.080 Uiso 1 1 calc R . . . . C12 C 0.3495(4) 0.77032(16) 0.21753(11) 0.0759(10) Uani 1 1 d . . . . . C13 C 0.4539(4) 0.80253(16) 0.22095(10) 0.0736(9) Uani 1 1 d . . . . . H13 H 0.5131 0.8046 0.1967 0.088 Uiso 1 1 calc R . . . . C14 C 0.4701(2) 0.83126(14) 0.25989(8) 0.0560(6) Uani 1 1 d . . . . . H14 H 0.5406 0.8519 0.2619 0.067 Uiso 1 1 calc R . . . . C15 C 0.3324(6) 0.7392(3) 0.17446(14) 0.125(2) Uani 1 1 d . . . . . H15A H 0.3455 0.6886 0.1744 0.188 Uiso 1 1 calc GR . . . . H15B H 0.3858 0.7608 0.1511 0.188 Uiso 1 1 calc GR . . . . H15C H 0.2549 0.7483 0.1706 0.188 Uiso 1 1 calc GR . . . . C16 C 0.40285(19) 0.94158(12) 0.33341(7) 0.0413(5) Uani 1 1 d . . . . . H16 H 0.4465 0.9559 0.3049 0.050 Uiso 1 1 calc R . . . . C17 C 0.46427(19) 0.97049(12) 0.36860(7) 0.0410(5) Uani 1 1 d . . . . . C18 C 0.39490(19) 0.94762(12) 0.41232(7) 0.0409(5) Uani 1 1 d . . . . . H18 H 0.4396 0.9578 0.4351 0.049 Uiso 1 1 calc R . . . . C19 C 0.2860(2) 0.99488(12) 0.41981(7) 0.0430(5) Uani 1 1 d . . . . . H19 H 0.2186 0.9746 0.4391 0.052 Uiso 1 1 calc R . . . . C20 C 0.2640(2) 1.02219(12) 0.37527(7) 0.0436(5) Uani 1 1 d . . . . . H20 H 0.1862 1.0421 0.3781 0.052 Uiso 1 1 calc R . . . . C21 C 0.2581(2) 0.99893(15) 0.29805(8) 0.0533(6) Uani 1 1 d . . . . . H21A H 0.2762 0.9620 0.2761 0.064 Uiso 1 1 calc R . . . . H21B H 0.3055 1.0401 0.2881 0.064 Uiso 1 1 calc R . . . . C22 C 0.1336(2) 1.01912(14) 0.30223(8) 0.0521(6) Uani 1 1 d . . . . . C23 C 0.1029(3) 1.08333(18) 0.28504(11) 0.0734(9) Uani 1 1 d . . . . . H23 H 0.1595 1.1150 0.2719 0.088 Uiso 1 1 calc R . . . . C24 C -0.0133(4) 1.0996(2) 0.28770(14) 0.0930(10) Uani 1 1 d . U . . . H24 H -0.0338 1.1421 0.2758 0.112 Uiso 1 1 calc R . . . . C25 C -0.0972(4) 1.0547(3) 0.30735(13) 0.0940(11) Uani 1 1 d . U . . . H25 H -0.1744 1.0669 0.3092 0.113 Uiso 1 1 calc R . . . . C26 C -0.0689(3) 0.9920(2) 0.32435(14) 0.0874(11) Uani 1 1 d . . . . . H26 H -0.1265 0.9613 0.3379 0.105 Uiso 1 1 calc R . . . . C27 C 0.0466(3) 0.97405(17) 0.32145(11) 0.0692(8) Uani 1 1 d . . . . . H27 H 0.0654 0.9307 0.3327 0.083 Uiso 1 1 calc R . . . . C28 C 0.3155(2) 1.07382(12) 0.42990(8) 0.0481(5) Uani 1 1 d . . . . . H28 H 0.2441 1.1007 0.4397 0.058 Uiso 1 1 calc R . . . . C29 C 0.3532(2) 1.08160(12) 0.38060(8) 0.0466(5) Uani 1 1 d . . . . . C30 C 0.4758(2) 1.05334(13) 0.36568(8) 0.0471(5) Uani 1 1 d . . . . . H30 H 0.5048 1.0676 0.3354 0.057 Uiso 1 1 calc R . . . . C31 C 0.5537(2) 1.08213(13) 0.39440(9) 0.0535(6) Uani 1 1 d . . . . . H31 H 0.6310 1.0907 0.3828 0.064 Uiso 1 1 calc R . . . . C32 C 0.5129(2) 1.09560(13) 0.43647(9) 0.0560(6) Uani 1 1 d . . . . . H32 H 0.5658 1.1085 0.4537 0.067 Uiso 1 1 calc R . . . . C33 C 0.3682(3) 1.07306(16) 0.50303(9) 0.0653(7) Uani 1 1 d . . . . . H33A H 0.4237 1.0949 0.5182 0.078 Uiso 1 1 calc R . . . . H33B H 0.3739 1.0218 0.5061 0.078 Uiso 1 1 calc R . . . . C34 C 0.2497(3) 1.09646(16) 0.52399(9) 0.0620(7) Uani 1 1 d . . . . . C35 C 0.1641(4) 1.0466(2) 0.53381(13) 0.0910(11) Uani 1 1 d . . . . . H35 H 0.1805 0.9988 0.5273 0.109 Uiso 1 1 calc R . . . . C36 C 0.0531(5) 1.0664(3) 0.55332(19) 0.1263(18) Uani 1 1 d . . . . . H36 H -0.0042 1.0319 0.5596 0.152 Uiso 1 1 calc R . . . . C37 C 0.0274(6) 1.1358(4) 0.56341(18) 0.136(2) Uani 1 1 d . . . . . H37 H -0.0470 1.1490 0.5765 0.163 Uiso 1 1 calc R . . . . C38 C 0.1124(6) 1.1856(3) 0.55410(18) 0.128(2) Uani 1 1 d . . . . . H38 H 0.0959 1.2332 0.5609 0.154 Uiso 1 1 calc R . . . . C39 C 0.2242(5) 1.1658(2) 0.53439(13) 0.0968(12) Uani 1 1 d . . . . . H39 H 0.2816 1.2003 0.5283 0.116 Uiso 1 1 calc R . . . . N1 N 0.39904(18) 0.86378(10) 0.33543(6) 0.0443(4) Uani 1 1 d . . . . . N2 N 0.58617(17) 0.94048(11) 0.35991(7) 0.0494(5) Uani 1 1 d . . . . . N3 N 0.28837(16) 0.97298(10) 0.33917(6) 0.0430(4) Uani 1 1 d . . . . . N4 N 0.3385(2) 1.15339(12) 0.36133(8) 0.0596(6) Uani 1 1 d . . . . . N5 N 0.3983(2) 1.09185(11) 0.45629(7) 0.0523(5) Uani 1 1 d . . . . . O1 O 0.3265(2) 0.87118(10) 0.48858(5) 0.0620(5) Uani 1 1 d . . . . . O2 O 0.62199(18) 0.91108(12) 0.38897(7) 0.0710(6) Uani 1 1 d . . . . . O3 O 0.64289(18) 0.94943(14) 0.32353(7) 0.0757(6) Uani 1 1 d . . . . . O4 O 0.2916(3) 1.19973(12) 0.38431(9) 0.1025(9) Uani 1 1 d . . . . . O5 O 0.3707(3) 1.16153(13) 0.32282(9) 0.1080(11) Uani 1 1 d . . . . . C1' C 0.9313(2) 0.33785(15) 0.45155(9) 0.0543(6) Uani 1 1 d . . . . . C2' C 0.9609(3) 0.26051(15) 0.45474(8) 0.0588(7) Uani 1 1 d . . . . . H2'A H 0.9151 0.2410 0.4812 0.071 Uiso 1 1 calc R . . . . H2'B H 1.0414 0.2565 0.4571 0.071 Uiso 1 1 calc R . . . . C3' C 0.9403(2) 0.21610(14) 0.41615(9) 0.0548(6) Uani 1 1 d . . . . . C4' C 1.0094(3) 0.25073(14) 0.37467(8) 0.0556(6) Uani 1 1 d . . . . . H4'A H 1.0908 0.2414 0.3734 0.067 Uiso 1 1 calc R . . . . H4'B H 0.9874 0.2285 0.3494 0.067 Uiso 1 1 calc R . . . . C5' C 0.9913(2) 0.33048(13) 0.37239(8) 0.0466(5) Uani 1 1 d . . . . . C6' C 0.9511(2) 0.36994(13) 0.40829(8) 0.0471(5) Uani 1 1 d . . . . . C7' C 0.8129(3) 0.21323(17) 0.41472(10) 0.0664(7) Uani 1 1 d . . . . . H7'A H 0.7716 0.1931 0.4414 0.100 Uiso 1 1 calc GR . . . . H7'B H 0.8013 0.1841 0.3906 0.100 Uiso 1 1 calc GR . . . . H7'C H 0.7851 0.2606 0.4112 0.100 Uiso 1 1 calc GR . . . . C8' C 0.9841(3) 0.13981(16) 0.42009(11) 0.0752(9) Uani 1 1 d . . . . . H8'A H 1.0646 0.1411 0.4216 0.113 Uiso 1 1 calc GR . . . . H8'B H 0.9736 0.1126 0.3951 0.113 Uiso 1 1 calc GR . . . . H8'C H 0.9417 0.1181 0.4460 0.113 Uiso 1 1 calc GR . . . . C9' C 1.0732(2) 0.32673(13) 0.29332(8) 0.0475(5) Uani 1 1 d . . . . . C10' C 1.1807(2) 0.29679(15) 0.29265(10) 0.0579(7) Uani 1 1 d . . . . . H10' H 1.2121 0.2950 0.3178 0.070 Uiso 1 1 calc R . . . . C11' C 1.2411(3) 0.26929(15) 0.25325(11) 0.0722(9) Uani 1 1 d . . . . . H11' H 1.3119 0.2472 0.2528 0.087 Uiso 1 1 calc R . . . . C12' C 1.1993(3) 0.27380(16) 0.21539(11) 0.0732(9) Uani 1 1 d . . . . . C13' C 1.0914(4) 0.30329(17) 0.21714(10) 0.0749(9) Uani 1 1 d . . . . . H13' H 1.0609 0.3058 0.1918 0.090 Uiso 1 1 calc R . . . . C14' C 1.0278(2) 0.32906(14) 0.25537(9) 0.0580(6) Uani 1 1 d . . . . . H14' H 0.9547 0.3480 0.2559 0.070 Uiso 1 1 calc R . . . . C15' C 1.2717(5) 0.2478(2) 0.17299(13) 0.1177(18) Uani 1 1 d . . . . . H15D H 1.2832 0.1973 0.1746 0.177 Uiso 1 1 calc GR . . . . H15E H 1.3450 0.2716 0.1681 0.177 Uiso 1 1 calc GR . . . . H15F H 1.2326 0.2582 0.1494 0.177 Uiso 1 1 calc GR . . . . C16' C 1.0069(2) 0.43910(13) 0.32823(8) 0.0452(5) Uani 1 1 d . . . . . H16' H 0.9970 0.4516 0.2987 0.054 Uiso 1 1 calc R . . . . C17' C 0.9048(2) 0.46824(13) 0.36057(8) 0.0458(5) Uani 1 1 d . . . . . C18' C 0.9214(2) 0.44732(13) 0.40592(8) 0.0474(5) Uani 1 1 d . . . . . H18' H 0.8500 0.4570 0.4268 0.057 Uiso 1 1 calc R . . . . C19' C 1.0176(2) 0.49751(14) 0.41562(8) 0.0515(6) Uani 1 1 d . . . . . H19' H 1.0611 0.4795 0.4372 0.062 Uiso 1 1 calc R . . . . C20' C 1.0926(2) 0.52330(13) 0.37206(8) 0.0501(6) Uani 1 1 d . . . . . H20' H 1.1652 0.5443 0.3769 0.060 Uiso 1 1 calc R . . . . C21' C 1.1856(2) 0.49913(16) 0.29586(9) 0.0595(7) Uani 1 1 d . . . . . H21C H 1.1484 0.5402 0.2856 0.071 Uiso 1 1 calc R . . . . H21D H 1.1907 0.4622 0.2739 0.071 Uiso 1 1 calc R . . . . C22' C 1.3055(2) 0.51989(15) 0.30071(9) 0.0577(7) Uani 1 1 d . . . . . C23' C 1.3523(3) 0.58307(19) 0.28255(12) 0.0795(9) Uani 1 1 d . . . . . H23' H 1.3072 0.6138 0.2694 0.095 Uiso 1 1 calc R . . . . C24' C 1.4657(4) 0.6011(3) 0.28369(15) 0.1033(15) Uani 1 1 d . . . . . H24' H 1.4962 0.6437 0.2713 0.124 Uiso 1 1 calc R . . . . C25' C 1.5332(3) 0.5561(3) 0.30315(14) 0.0995(14) Uani 1 1 d . . . . . H25' H 1.6098 0.5674 0.3035 0.119 Uiso 1 1 calc R . . . . C26' C 1.4861(3) 0.4954(3) 0.32172(16) 0.0989(13) Uani 1 1 d . . . . . H26' H 1.5308 0.4652 0.3354 0.119 Uiso 1 1 calc R . . . . C27' C 1.3735(3) 0.47696(19) 0.32103(13) 0.0800(10) Uani 1 1 d . . . . . H27' H 1.3432 0.4350 0.3344 0.096 Uiso 1 1 calc R . . . . C28' C 0.9742(3) 0.57570(14) 0.42292(9) 0.0557(6) Uani 1 1 d . . . . . H28' H 1.0304 0.6043 0.4348 0.067 Uiso 1 1 calc R . . . . C29' C 0.9972(2) 0.58162(13) 0.37338(9) 0.0523(6) Uani 1 1 d . . . . . C30' C 0.8960(2) 0.55103(13) 0.35516(8) 0.0504(6) Uani 1 1 d . . . . . H30' H 0.9043 0.5632 0.3242 0.060 Uiso 1 1 calc R . . . . C31' C 0.7839(3) 0.57992(15) 0.38006(9) 0.0586(7) Uani 1 1 d . . . . . H31' H 0.7224 0.5874 0.3659 0.070 Uiso 1 1 calc R . . . . C32' C 0.7722(3) 0.59495(17) 0.42234(10) 0.0681(8) Uani 1 1 d . . . . . H32' H 0.6995 0.6086 0.4371 0.082 Uiso 1 1 calc R . . . . C33' C 0.8398(4) 0.5800(3) 0.49234(13) 0.1177(16) Uani 1 1 d . U . . . H33C H 0.8983 0.6059 0.5041 0.141 Uiso 1 1 calc R . . . . H33D H 0.8504 0.5296 0.4976 0.141 Uiso 1 1 calc R . . . . C34' C 0.7252(4) 0.6017(2) 0.51652(11) 0.0844(10) Uani 1 1 d . . . . . C35' C 0.6977(5) 0.6706(3) 0.52943(15) 0.1081(14) Uani 1 1 d . . . . . H35' H 0.7552 0.7050 0.5230 0.130 Uiso 1 1 calc R . . . . C36' C 0.5918(6) 0.6919(3) 0.55101(19) 0.137(2) Uani 1 1 d . U . . . H36' H 0.5774 0.7392 0.5591 0.164 Uiso 1 1 calc R . . . . C37' C 0.5110(7) 0.6432(5) 0.5599(2) 0.167(3) Uani 1 1 d . U . . . H37' H 0.4387 0.6573 0.5748 0.200 Uiso 1 1 calc R . . . . C38' C 0.5263(7) 0.5743(4) 0.5489(3) 0.181(3) Uani 1 1 d . U . . . H38' H 0.4660 0.5419 0.5557 0.217 Uiso 1 1 calc R . . . . C39' C 0.6372(7) 0.5518(3) 0.5265(2) 0.149(2) Uani 1 1 d . U . . . H39' H 0.6504 0.5043 0.5186 0.179 Uiso 1 1 calc R . . . . N1' N 1.01108(18) 0.36099(10) 0.33169(6) 0.0456(4) Uani 1 1 d . . . . . N2' N 0.79671(19) 0.43673(12) 0.34870(8) 0.0550(5) Uani 1 1 d . . . . . N3' N 1.11258(17) 0.47298(11) 0.33659(7) 0.0474(5) Uani 1 1 d . . . . . N4' N 1.0344(2) 0.65298(12) 0.35376(9) 0.0645(6) Uani 1 1 d . . . . . N5' N 0.8592(2) 0.59173(13) 0.44557(8) 0.0609(6) Uani 1 1 d . . . . . O1' O 0.8950(2) 0.37354(11) 0.48405(6) 0.0718(6) Uani 1 1 d . . . . . O2' O 0.7287(2) 0.40624(14) 0.37631(8) 0.0832(7) Uani 1 1 d . . . . . O3' O 0.7832(2) 0.44481(14) 0.31100(8) 0.0791(6) Uani 1 1 d . . . . . O4' O 1.0620(3) 0.69826(14) 0.37696(10) 0.1136(11) Uani 1 1 d . . . . . O5' O 1.0419(4) 0.66117(14) 0.31531(9) 0.1131(11) Uani 1 1 d . . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 C1 0.0493(13) 0.0465(13) 0.0445(13) 0.0012(10) -0.0014(10) -0.0037(11) C2 0.0683(17) 0.0501(14) 0.0496(14) 0.0047(11) 0.0041(12) -0.0085(12) C3 0.0674(17) 0.0457(13) 0.0520(15) 0.0042(10) 0.0013(12) -0.0004(12) C4 0.0663(17) 0.0447(13) 0.0507(13) -0.0049(10) -0.0089(12) -0.0018(12) C5 0.0416(11) 0.0448(12) 0.0412(11) -0.0028(9) -0.0058(9) -0.0010(10) C6 0.0422(11) 0.0425(12) 0.0388(11) -0.0003(9) -0.0051(9) -0.0007(10) C7 0.073(2) 0.078(2) 0.0668(19) 0.0147(15) -0.0047(16) 0.0192(16) C8 0.130(3) 0.0447(15) 0.071(2) 0.0002(13) 0.001(2) -0.0078(18) C9 0.0520(13) 0.0439(12) 0.0442(13) -0.0036(9) -0.0151(10) 0.0025(10) C10 0.0515(15) 0.0602(16) 0.0645(17) -0.0051(12) -0.0194(13) -0.0016(12) C11 0.0740(18) 0.0560(15) 0.080(2) -0.0061(14) -0.0412(17) 0.0013(13) C12 0.119(3) 0.0547(16) 0.0641(19) -0.0120(13) -0.045(2) 0.0080(18) C13 0.108(3) 0.0609(17) 0.0470(15) -0.0107(12) -0.0015(16) 0.0049(18) C14 0.0619(15) 0.0549(14) 0.0500(14) -0.0061(11) -0.0073(12) 0.0019(12) C15 0.206(6) 0.105(3) 0.082(3) -0.031(2) -0.071(3) 0.000(3) C16 0.0399(11) 0.0475(12) 0.0364(11) -0.0003(9) -0.0070(9) -0.0030(10) C17 0.0361(11) 0.0439(12) 0.0433(12) 0.0020(9) -0.0085(9) -0.0022(9) C18 0.0417(11) 0.0444(12) 0.0385(11) -0.0005(9) -0.0126(9) -0.0028(9) C19 0.0419(12) 0.0473(12) 0.0402(11) -0.0047(9) -0.0084(9) -0.0010(10) C20 0.0417(12) 0.0457(12) 0.0458(12) -0.0018(9) -0.0145(10) 0.0029(10) C21 0.0566(15) 0.0651(16) 0.0407(12) 0.0052(11) -0.0157(11) -0.0029(12) C22 0.0588(15) 0.0569(15) 0.0464(13) -0.0064(11) -0.0250(12) 0.0037(12) C23 0.088(2) 0.074(2) 0.0653(19) 0.0045(14) -0.0320(17) 0.0125(17) C24 0.109(3) 0.092(2) 0.088(2) -0.0065(18) -0.044(2) 0.0442(18) C25 0.075(2) 0.122(3) 0.096(3) -0.027(2) -0.0444(19) 0.0352(17) C26 0.0542(17) 0.102(3) 0.110(3) -0.019(2) -0.0268(19) -0.0037(18) C27 0.0582(17) 0.0646(18) 0.090(2) -0.0045(15) -0.0270(16) -0.0018(14) C28 0.0517(13) 0.0445(12) 0.0511(13) -0.0052(10) -0.0173(11) 0.0058(10) C29 0.0549(14) 0.0394(12) 0.0494(13) 0.0027(9) -0.0200(11) -0.0022(10) C30 0.0502(13) 0.0429(12) 0.0499(13) 0.0049(10) -0.0137(10) -0.0064(10) C31 0.0491(13) 0.0494(13) 0.0650(16) 0.0053(11) -0.0185(12) -0.0122(11) C32 0.0617(16) 0.0465(13) 0.0672(17) -0.0016(11) -0.0309(13) -0.0068(12) C33 0.080(2) 0.0643(17) 0.0568(17) 0.0015(12) -0.0252(14) 0.0024(15) C34 0.0788(19) 0.0629(16) 0.0470(14) -0.0071(11) -0.0189(13) 0.0045(15) C35 0.096(3) 0.080(2) 0.092(3) -0.0002(19) -0.005(2) -0.003(2) C36 0.083(3) 0.144(5) 0.139(4) 0.020(4) 0.014(3) -0.007(3) C37 0.115(4) 0.164(6) 0.109(4) 0.023(4) 0.027(3) 0.052(4) C38 0.156(5) 0.104(4) 0.113(4) -0.014(3) 0.007(4) 0.053(4) C39 0.121(3) 0.076(2) 0.090(3) -0.0102(19) -0.011(2) 0.010(2) N1 0.0488(10) 0.0462(10) 0.0375(10) -0.0032(8) -0.0070(8) -0.0029(9) N2 0.0379(10) 0.0539(12) 0.0563(12) 0.0001(9) -0.0091(9) -0.0041(9) N3 0.0400(10) 0.0505(11) 0.0401(10) -0.0024(8) -0.0120(8) -0.0013(8) N4 0.0701(15) 0.0451(12) 0.0696(15) 0.0050(10) -0.0287(12) 0.0005(11) N5 0.0610(13) 0.0497(12) 0.0511(12) -0.0073(9) -0.0227(10) -0.0009(10) O1 0.0890(14) 0.0573(10) 0.0383(9) -0.0020(7) -0.0086(9) -0.0100(10) O2 0.0542(11) 0.0885(15) 0.0738(13) 0.0093(11) -0.0211(10) 0.0156(11) O3 0.0472(10) 0.1083(17) 0.0671(13) 0.0081(11) 0.0007(10) 0.0035(11) O4 0.151(3) 0.0538(13) 0.1031(19) 0.0021(12) -0.0252(19) 0.0335(16) O5 0.165(3) 0.0726(15) 0.0837(18) 0.0288(13) -0.0154(19) 0.0219(17) C1' 0.0554(14) 0.0594(15) 0.0485(14) 0.0058(11) -0.0106(11) -0.0044(12) C2' 0.0628(16) 0.0646(16) 0.0497(14) 0.0139(12) -0.0127(12) -0.0034(13) C3' 0.0581(15) 0.0526(14) 0.0524(15) 0.0120(11) -0.0072(12) -0.0017(12) C4' 0.0600(15) 0.0497(14) 0.0533(15) 0.0068(11) -0.0007(12) 0.0022(12) C5' 0.0423(12) 0.0492(13) 0.0469(13) 0.0076(10) -0.0049(10) -0.0012(10) C6' 0.0466(12) 0.0483(13) 0.0444(12) 0.0045(10) -0.0037(10) -0.0028(10) C7' 0.0664(18) 0.0657(17) 0.0664(18) 0.0134(13) -0.0108(14) -0.0134(14) C8' 0.093(2) 0.0552(16) 0.074(2) 0.0163(14) -0.0063(18) 0.0063(16) C9' 0.0439(12) 0.0463(12) 0.0481(13) 0.0038(10) 0.0025(10) -0.0020(10) C10' 0.0467(14) 0.0582(16) 0.0649(17) 0.0074(12) -0.0001(12) -0.0003(12) C11' 0.0559(16) 0.0560(15) 0.092(2) 0.0022(16) 0.0195(17) 0.0042(13) C12' 0.089(2) 0.0580(17) 0.0617(19) -0.0097(13) 0.0152(17) -0.0027(17) C13' 0.102(3) 0.0680(19) 0.0555(17) -0.0093(14) -0.0156(17) -0.0033(19) C14' 0.0608(15) 0.0557(14) 0.0571(15) -0.0012(12) -0.0103(13) -0.0016(12) C15' 0.148(4) 0.093(3) 0.087(3) -0.023(2) 0.040(3) 0.002(3) C16' 0.0437(12) 0.0486(13) 0.0433(12) 0.0055(9) -0.0080(10) 0.0018(10) C17' 0.0396(11) 0.0498(13) 0.0482(13) 0.0029(10) -0.0087(10) 0.0020(10) C18' 0.0439(12) 0.0505(13) 0.0459(13) 0.0022(10) -0.0035(10) 0.0022(10) C19' 0.0508(13) 0.0565(14) 0.0488(13) 0.0023(11) -0.0138(11) 0.0018(11) C20' 0.0428(12) 0.0520(14) 0.0565(14) 0.0045(11) -0.0122(11) -0.0018(11) C21' 0.0503(14) 0.0635(16) 0.0619(16) 0.0112(13) -0.0040(13) -0.0026(12) C22' 0.0483(14) 0.0579(15) 0.0612(16) -0.0021(12) 0.0046(12) -0.0009(12) C23' 0.077(2) 0.079(2) 0.078(2) 0.0117(16) -0.0020(18) -0.0200(18) C24' 0.092(3) 0.114(3) 0.095(3) 0.002(2) 0.005(2) -0.056(3) C25' 0.0542(19) 0.142(4) 0.095(3) -0.028(3) 0.003(2) -0.026(2) C26' 0.0546(19) 0.120(3) 0.124(3) -0.017(3) -0.020(2) 0.015(2) C27' 0.0551(17) 0.0690(19) 0.116(3) 0.0037(18) -0.0155(18) 0.0054(15) C28' 0.0583(15) 0.0514(14) 0.0594(15) -0.0040(11) -0.0158(12) 0.0007(12) C29' 0.0517(13) 0.0444(13) 0.0609(15) 0.0047(11) -0.0110(12) 0.0010(11) C30' 0.0517(13) 0.0481(13) 0.0520(14) 0.0043(10) -0.0117(11) 0.0053(11) C31' 0.0557(15) 0.0604(16) 0.0609(16) 0.0016(12) -0.0137(12) 0.0160(13) C32' 0.0602(16) 0.0752(19) 0.0678(18) -0.0070(14) -0.0095(14) 0.0229(15) C33' 0.106(3) 0.182(5) 0.064(2) -0.009(2) -0.013(2) 0.031(3) C34' 0.094(3) 0.096(2) 0.0571(18) -0.0038(16) -0.0001(18) 0.005(2) C35' 0.120(4) 0.094(3) 0.106(3) -0.016(2) -0.009(3) -0.017(3) C36' 0.144(4) 0.125(4) 0.129(4) -0.043(3) 0.004(3) 0.020(3) C37' 0.137(5) 0.184(6) 0.150(5) -0.034(5) 0.045(4) -0.001(4) C38' 0.156(5) 0.172(6) 0.189(6) 0.027(5) 0.036(5) -0.069(5) C39' 0.183(6) 0.097(3) 0.158(5) 0.014(3) -0.008(4) -0.027(4) N1' 0.0457(10) 0.0453(10) 0.0437(10) 0.0030(8) -0.0031(8) 0.0016(9) N2' 0.0432(11) 0.0606(13) 0.0611(14) -0.0001(10) -0.0094(10) 0.0016(10) N3' 0.0410(10) 0.0507(11) 0.0494(11) 0.0076(9) -0.0052(8) -0.0013(9) N4' 0.0672(15) 0.0479(13) 0.0764(17) 0.0027(11) -0.0086(12) -0.0009(11) N5' 0.0660(14) 0.0601(13) 0.0562(13) -0.0072(10) -0.0105(11) 0.0075(11) O1' 0.0964(16) 0.0698(13) 0.0450(10) 0.0023(9) -0.0025(10) 0.0017(11) O2' 0.0561(12) 0.1036(17) 0.0874(16) 0.0136(13) -0.0070(11) -0.0223(12) O3' 0.0622(12) 0.1094(18) 0.0705(14) -0.0002(12) -0.0250(11) -0.0095(12) O4' 0.163(3) 0.0634(15) 0.111(2) -0.0072(14) -0.016(2) -0.0332(18) O5' 0.181(3) 0.0764(16) 0.0826(18) 0.0286(13) -0.028(2) -0.0359(19) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag C1 C2 1.502(3) . ? C1 C6 1.450(3) . ? C1 O1 1.226(3) . ? C2 H2A 0.9700 . ? C2 H2B 0.9700 . ? C2 C3 1.524(4) . ? C3 C4 1.527(4) . ? C3 C7 1.527(5) . ? C3 C8 1.520(4) . ? C4 H4A 0.9700 . ? C4 H4B 0.9700 . ? C4 C5 1.503(3) . ? C5 C6 1.370(3) . ? C5 N1 1.378(3) . ? C6 C18 1.502(3) . ? C7 H7A 0.9600 . ? C7 H7B 0.9600 . ? C7 H7C 0.9600 . ? C8 H8A 0.9600 . ? C8 H8B 0.9600 . ? C8 H8C 0.9600 . ? C9 C10 1.388(4) . ? C9 C14 1.382(4) . ? C9 N1 1.439(3) . ? C10 H10 0.9300 . ? C10 C11 1.361(4) . ? C11 H11 0.9300 . ? C11 C12 1.376(5) . ? C12 C13 1.394(6) . ? C12 C15 1.516(4) . ? C13 H13 0.9300 . ? C13 C14 1.377(4) . ? C14 H14 0.9300 . ? C15 H15A 0.9600 . ? C15 H15B 0.9600 . ? C15 H15C 0.9600 . ? C16 H16 0.9800 . ? C16 C17 1.526(3) . ? C16 N1 1.460(3) . ? C16 N3 1.454(3) . ? C17 C18 1.517(3) . ? C17 C30 1.560(3) . ? C17 N2 1.521(3) . ? C18 H18 0.9800 . ? C18 C19 1.542(3) . ? C19 H19 0.9800 . ? C19 C20 1.550(3) . ? C19 C28 1.566(3) . ? C20 H20 0.9800 . ? C20 C29 1.563(3) . ? C20 N3 1.444(3) . ? C21 H21A 0.9700 . ? C21 H21B 0.9700 . ? C21 C22 1.500(4) . ? C21 N3 1.480(3) . ? C22 C23 1.394(4) . ? C22 C27 1.377(4) . ? C23 H23 0.9300 . ? C23 C24 1.393(5) . ? C24 H24 0.9300 . ? C24 C25 1.355(7) . ? C25 H25 0.9300 . ? C25 C26 1.356(6) . ? C26 H26 0.9300 . ? C26 C27 1.391(5) . ? C27 H27 0.9300 . ? C28 H28 0.9800 . ? C28 C29 1.528(3) . ? C28 N5 1.433(3) . ? C29 C30 1.529(4) . ? C29 N4 1.498(3) . ? C30 H30 0.9800 . ? C30 C31 1.501(3) . ? C31 H31 0.9300 . ? C31 C32 1.336(4) . ? C32 H32 0.9300 . ? C32 N5 1.380(4) . ? C33 H33A 0.9700 . ? C33 H33B 0.9700 . ? C33 C34 1.495(4) . ? C33 N5 1.479(4) . ? C34 C35 1.368(5) . ? C34 C39 1.359(5) . ? C35 H35 0.9300 . ? C35 C36 1.387(7) . ? C36 H36 0.9300 . ? C36 C37 1.359(8) . ? C37 H37 0.9300 . ? C37 C38 1.361(9) . ? C38 H38 0.9300 . ? C38 C39 1.397(7) . ? C39 H39 0.9300 . ? N2 O2 1.205(3) . ? N2 O3 1.218(3) . ? N4 O4 1.195(3) . ? N4 O5 1.202(3) . ? C1' C2' 1.499(4) . ? C1' C6' 1.458(3) . ? C1' O1' 1.224(3) . ? C2' H2'A 0.9700 . ? C2' H2'B 0.9700 . ? C2' C3' 1.522(4) . ? C3' C4' 1.540(3) . ? C3' C7' 1.513(4) . ? C3' C8' 1.534(4) . ? C4' H4'A 0.9700 . ? C4' H4'B 0.9700 . ? C4' C5' 1.514(3) . ? C5' C6' 1.353(3) . ? C5' N1' 1.374(3) . ? C6' C18' 1.497(3) . ? C7' H7'A 0.9600 . ? C7' H7'B 0.9600 . ? C7' H7'C 0.9600 . ? C8' H8'A 0.9600 . ? C8' H8'B 0.9600 . ? C8' H8'C 0.9600 . ? C9' C10' 1.384(4) . ? C9' C14' 1.391(4) . ? C9' N1' 1.434(3) . ? C10' H10' 0.9300 . ? C10' C11' 1.400(4) . ? C11' H11' 0.9300 . ? C11' C12' 1.368(5) . ? C12' C13' 1.381(6) . ? C12' C15' 1.515(4) . ? C13' H13' 0.9300 . ? C13' C14' 1.373(4) . ? C14' H14' 0.9300 . ? C15' H15D 0.9600 . ? C15' H15E 0.9600 . ? C15' H15F 0.9600 . ? C16' H16' 0.9800 . ? C16' C17' 1.521(3) . ? C16' N1' 1.470(3) . ? C16' N3' 1.467(3) . ? C17' C18' 1.519(3) . ? C17' C30' 1.567(3) . ? C17' N2' 1.514(3) . ? C18' H18' 0.9800 . ? C18' C19' 1.549(4) . ? C19' H19' 0.9800 . ? C19' C20' 1.555(3) . ? C19' C28' 1.556(4) . ? C20' H20' 0.9800 . ? C20' C29' 1.565(4) . ? C20' N3' 1.441(3) . ? C21' H21C 0.9700 . ? C21' H21D 0.9700 . ? C21' C22' 1.504(4) . ? C21' N3' 1.480(3) . ? C22' C23' 1.383(4) . ? C22' C27' 1.374(5) . ? C23' H23' 0.9300 . ? C23' C24' 1.387(6) . ? C24' H24' 0.9300 . ? C24' C25' 1.378(7) . ? C25' H25' 0.9300 . ? C25' C26' 1.349(6) . ? C26' H26' 0.9300 . ? C26' C27' 1.377(5) . ? C27' H27' 0.9300 . ? C28' H28' 0.9800 . ? C28' C29' 1.525(4) . ? C28' N5' 1.439(4) . ? C29' C30' 1.528(4) . ? C29' N4' 1.502(3) . ? C30' H30' 0.9800 . ? C30' C31' 1.504(4) . ? C31' H31' 0.9300 . ? C31' C32' 1.333(4) . ? C32' H32' 0.9300 . ? C32' N5' 1.366(4) . ? C33' H33C 0.9700 . ? C33' H33D 0.9700 . ? C33' C34' 1.478(6) . ? C33' N5' 1.453(5) . ? C34' C35' 1.373(6) . ? C34' C39' 1.388(7) . ? C35' H35' 0.9300 . ? C35' C36' 1.364(8) . ? C36' H36' 0.9300 . ? C36' C37' 1.312(9) . ? C37' H37' 0.9300 . ? C37' C38' 1.340(9) . ? C38' H38' 0.9300 . ? C38' C39' 1.427(10) . ? C39' H39' 0.9300 . ? N2' O2' 1.206(3) . ? N2' O3' 1.228(3) . ? N4' O4' 1.200(4) . ? N4' O5' 1.198(3) . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C6 C1 C2 118.0(2) . . ? O1 C1 C2 121.3(2) . . ? O1 C1 C6 120.7(2) . . ? C1 C2 H2A 108.8 . . ? C1 C2 H2B 108.8 . . ? C1 C2 C3 113.8(2) . . ? H2A C2 H2B 107.7 . . ? C3 C2 H2A 108.8 . . ? C3 C2 H2B 108.8 . . ? C2 C3 C4 107.4(2) . . ? C2 C3 C7 109.5(3) . . ? C7 C3 C4 111.0(2) . . ? C8 C3 C2 109.4(2) . . ? C8 C3 C4 108.4(3) . . ? C8 C3 C7 111.0(3) . . ? C3 C4 H4A 108.6 . . ? C3 C4 H4B 108.6 . . ? H4A C4 H4B 107.6 . . ? C5 C4 C3 114.5(2) . . ? C5 C4 H4A 108.6 . . ? C5 C4 H4B 108.6 . . ? C6 C5 C4 121.3(2) . . ? C6 C5 N1 119.8(2) . . ? N1 C5 C4 118.7(2) . . ? C1 C6 C18 116.8(2) . . ? C5 C6 C1 120.7(2) . . ? C5 C6 C18 122.5(2) . . ? C3 C7 H7A 109.5 . . ? C3 C7 H7B 109.5 . . ? C3 C7 H7C 109.5 . . ? H7A C7 H7B 109.5 . . ? H7A C7 H7C 109.5 . . ? H7B C7 H7C 109.5 . . ? C3 C8 H8A 109.5 . . ? C3 C8 H8B 109.5 . . ? C3 C8 H8C 109.5 . . ? H8A C8 H8B 109.5 . . ? H8A C8 H8C 109.5 . . ? H8B C8 H8C 109.5 . . ? C10 C9 N1 121.9(2) . . ? C14 C9 C10 119.0(2) . . ? C14 C9 N1 118.9(2) . . ? C9 C10 H10 119.8 . . ? C11 C10 C9 120.4(3) . . ? C11 C10 H10 119.8 . . ? C10 C11 H11 119.3 . . ? C10 C11 C12 121.4(3) . . ? C12 C11 H11 119.3 . . ? C11 C12 C13 118.3(3) . . ? C11 C12 C15 121.5(4) . . ? C13 C12 C15 120.2(4) . . ? C12 C13 H13 119.7 . . ? C14 C13 C12 120.6(3) . . ? C14 C13 H13 119.7 . . ? C9 C14 H14 119.9 . . ? C13 C14 C9 120.2(3) . . ? C13 C14 H14 119.9 . . ? C12 C15 H15A 109.5 . . ? C12 C15 H15B 109.5 . . ? C12 C15 H15C 109.5 . . ? H15A C15 H15B 109.5 . . ? H15A C15 H15C 109.5 . . ? H15B C15 H15C 109.5 . . ? C17 C16 H16 108.6 . . ? N1 C16 H16 108.6 . . ? N1 C16 C17 109.77(18) . . ? N3 C16 H16 108.6 . . ? N3 C16 C17 108.88(18) . . ? N3 C16 N1 112.26(18) . . ? C16 C17 C30 111.06(19) . . ? C18 C17 C16 107.45(18) . . ? C18 C17 C30 111.12(19) . . ? C18 C17 N2 112.85(19) . . ? N2 C17 C16 107.58(18) . . ? N2 C17 C30 106.76(18) . . ? C6 C18 C17 111.23(18) . . ? C6 C18 H18 109.0 . . ? C6 C18 C19 113.00(19) . . ? C17 C18 H18 109.0 . . ? C17 C18 C19 105.51(18) . . ? C19 C18 H18 109.0 . . ? C18 C19 H19 115.3 . . ? C18 C19 C20 109.22(18) . . ? C18 C19 C28 111.25(19) . . ? C20 C19 H19 115.3 . . ? C20 C19 C28 87.14(17) . . ? C28 C19 H19 115.3 . . ? C19 C20 H20 111.0 . . ? C19 C20 C29 84.79(17) . . ? C29 C20 H20 111.0 . . ? N3 C20 C19 116.64(19) . . ? N3 C20 H20 111.0 . . ? N3 C20 C29 120.0(2) . . ? H21A C21 H21B 107.7 . . ? C22 C21 H21A 108.8 . . ? C22 C21 H21B 108.8 . . ? N3 C21 H21A 108.8 . . ? N3 C21 H21B 108.8 . . ? N3 C21 C22 113.6(2) . . ? C23 C22 C21 120.4(3) . . ? C27 C22 C21 121.4(3) . . ? C27 C22 C23 118.1(3) . . ? C22 C23 H23 120.3 . . ? C24 C23 C22 119.4(4) . . ? C24 C23 H23 120.3 . . ? C23 C24 H24 119.4 . . ? C25 C24 C23 121.2(4) . . ? C25 C24 H24 119.4 . . ? C24 C25 H25 119.9 . . ? C24 C25 C26 120.2(4) . . ? C26 C25 H25 119.9 . . ? C25 C26 H26 120.2 . . ? C25 C26 C27 119.7(4) . . ? C27 C26 H26 120.2 . . ? C22 C27 C26 121.4(3) . . ? C22 C27 H27 119.3 . . ? C26 C27 H27 119.3 . . ? C19 C28 H28 109.7 . . ? C29 C28 C19 85.46(17) . . ? C29 C28 H28 109.7 . . ? N5 C28 C19 122.7(2) . . ? N5 C28 H28 109.7 . . ? N5 C28 C29 117.2(2) . . ? C28 C29 C20 88.01(18) . . ? C28 C29 C30 110.7(2) . . ? C30 C29 C20 109.79(19) . . ? N4 C29 C20 117.7(2) . . ? N4 C29 C28 117.2(2) . . ? N4 C29 C30 111.3(2) . . ? C17 C30 H30 109.7 . . ? C29 C30 C17 105.06(19) . . ? C29 C30 H30 109.7 . . ? C31 C30 C17 112.3(2) . . ? C31 C30 C29 110.1(2) . . ? C31 C30 H30 109.7 . . ? C30 C31 H31 119.7 . . ? C32 C31 C30 120.6(2) . . ? C32 C31 H31 119.7 . . ? C31 C32 H32 117.5 . . ? C31 C32 N5 125.0(2) . . ? N5 C32 H32 117.5 . . ? H33A C33 H33B 107.8 . . ? C34 C33 H33A 108.9 . . ? C34 C33 H33B 108.9 . . ? N5 C33 H33A 108.9 . . ? N5 C33 H33B 108.9 . . ? N5 C33 C34 113.2(2) . . ? C35 C34 C33 119.2(3) . . ? C39 C34 C33 122.1(3) . . ? C39 C34 C35 118.6(4) . . ? C34 C35 H35 119.6 . . ? C34 C35 C36 120.8(4) . . ? C36 C35 H35 119.6 . . ? C35 C36 H36 119.7 . . ? C37 C36 C35 120.6(5) . . ? C37 C36 H36 119.7 . . ? C36 C37 H37 120.5 . . ? C36 C37 C38 118.9(5) . . ? C38 C37 H37 120.5 . . ? C37 C38 H38 119.7 . . ? C37 C38 C39 120.6(5) . . ? C39 C38 H38 119.7 . . ? C34 C39 C38 120.5(5) . . ? C34 C39 H39 119.8 . . ? C38 C39 H39 119.8 . . ? C5 N1 C9 122.06(19) . . ? C5 N1 C16 119.54(18) . . ? C9 N1 C16 114.67(18) . . ? O2 N2 C17 119.3(2) . . ? O2 N2 O3 123.9(2) . . ? O3 N2 C17 116.8(2) . . ? C16 N3 C21 113.36(19) . . ? C20 N3 C16 113.53(18) . . ? C20 N3 C21 115.06(19) . . ? O4 N4 C29 119.1(3) . . ? O4 N4 O5 122.2(3) . . ? O5 N4 C29 118.6(2) . . ? C28 N5 C33 116.7(2) . . ? C32 N5 C28 118.1(2) . . ? C32 N5 C33 119.2(2) . . ? C6' C1' C2' 117.5(2) . . ? O1' C1' C2' 121.5(2) . . ? O1' C1' C6' 120.9(3) . . ? C1' C2' H2'A 108.8 . . ? C1' C2' H2'B 108.8 . . ? C1' C2' C3' 113.7(2) . . ? H2'A C2' H2'B 107.7 . . ? C3' C2' H2'A 108.8 . . ? C3' C2' H2'B 108.8 . . ? C2' C3' C4' 107.4(2) . . ? C2' C3' C8' 109.8(2) . . ? C7' C3' C2' 110.5(3) . . ? C7' C3' C4' 111.2(2) . . ? C7' C3' C8' 108.8(3) . . ? C8' C3' C4' 109.1(2) . . ? C3' C4' H4'A 108.9 . . ? C3' C4' H4'B 108.9 . . ? H4'A C4' H4'B 107.7 . . ? C5' C4' C3' 113.5(2) . . ? C5' C4' H4'A 108.9 . . ? C5' C4' H4'B 108.9 . . ? C6' C5' C4' 122.1(2) . . ? C6' C5' N1' 120.8(2) . . ? N1' C5' C4' 117.0(2) . . ? C1' C6' C18' 116.6(2) . . ? C5' C6' C1' 120.9(2) . . ? C5' C6' C18' 122.5(2) . . ? C3' C7' H7'A 109.5 . . ? C3' C7' H7'B 109.5 . . ? C3' C7' H7'C 109.5 . . ? H7'A C7' H7'B 109.5 . . ? H7'A C7' H7'C 109.5 . . ? H7'B C7' H7'C 109.5 . . ? C3' C8' H8'A 109.5 . . ? C3' C8' H8'B 109.5 . . ? C3' C8' H8'C 109.5 . . ? H8'A C8' H8'B 109.5 . . ? H8'A C8' H8'C 109.5 . . ? H8'B C8' H8'C 109.5 . . ? C10' C9' C14' 120.0(2) . . ? C10' C9' N1' 121.1(2) . . ? C14' C9' N1' 118.7(2) . . ? C9' C10' H10' 120.8 . . ? C9' C10' C11' 118.4(3) . . ? C11' C10' H10' 120.8 . . ? C10' C11' H11' 118.9 . . ? C12' C11' C10' 122.1(3) . . ? C12' C11' H11' 118.9 . . ? C11' C12' C13' 118.1(3) . . ? C11' C12' C15' 120.1(4) . . ? C13' C12' C15' 121.8(4) . . ? C12' C13' H13' 119.2 . . ? C14' C13' C12' 121.6(3) . . ? C14' C13' H13' 119.2 . . ? C9' C14' H14' 120.1 . . ? C13' C14' C9' 119.7(3) . . ? C13' C14' H14' 120.1 . . ? C12' C15' H15D 109.5 . . ? C12' C15' H15E 109.5 . . ? C12' C15' H15F 109.5 . . ? H15D C15' H15E 109.5 . . ? H15D C15' H15F 109.5 . . ? H15E C15' H15F 109.5 . . ? C17' C16' H16' 108.7 . . ? N1' C16' H16' 108.7 . . ? N1' C16' C17' 110.02(19) . . ? N3' C16' H16' 108.7 . . ? N3' C16' C17' 108.7(2) . . ? N3' C16' N1' 112.12(19) . . ? C16' C17' C30' 110.12(19) . . ? C18' C17' C16' 107.6(2) . . ? C18' C17' C30' 112.3(2) . . ? N2' C17' C16' 107.2(2) . . ? N2' C17' C18' 113.0(2) . . ? N2' C17' C30' 106.5(2) . . ? C6' C18' C17' 111.6(2) . . ? C6' C18' H18' 109.1 . . ? C6' C18' C19' 113.0(2) . . ? C17' C18' H18' 109.1 . . ? C17' C18' C19' 104.74(19) . . ? C19' C18' H18' 109.1 . . ? C18' C19' H19' 115.1 . . ? C18' C19' C20' 109.6(2) . . ? C18' C19' C28' 111.5(2) . . ? C20' C19' H19' 115.1 . . ? C20' C19' C28' 87.31(19) . . ? C28' C19' H19' 115.1 . . ? C19' C20' H20' 111.1 . . ? C19' C20' C29' 84.60(19) . . ? C29' C20' H20' 111.1 . . ? N3' C20' C19' 117.0(2) . . ? N3' C20' H20' 111.1 . . ? N3' C20' C29' 119.3(2) . . ? H21C C21' H21D 107.7 . . ? C22' C21' H21C 108.8 . . ? C22' C21' H21D 108.8 . . ? N3' C21' H21C 108.8 . . ? N3' C21' H21D 108.8 . . ? N3' C21' C22' 113.9(2) . . ? C23' C22' C21' 119.4(3) . . ? C27' C22' C21' 122.6(3) . . ? C27' C22' C23' 118.0(3) . . ? C22' C23' H23' 119.7 . . ? C22' C23' C24' 120.7(4) . . ? C24' C23' H23' 119.7 . . ? C23' C24' H24' 119.9 . . ? C25' C24' C23' 120.2(4) . . ? C25' C24' H24' 119.9 . . ? C24' C25' H25' 120.6 . . ? C26' C25' C24' 118.7(4) . . ? C26' C25' H25' 120.6 . . ? C25' C26' H26' 119.2 . . ? C25' C26' C27' 121.7(4) . . ? C27' C26' H26' 119.2 . . ? C22' C27' C26' 120.7(4) . . ? C22' C27' H27' 119.7 . . ? C26' C27' H27' 119.7 . . ? C19' C28' H28' 110.0 . . ? C29' C28' C19' 85.92(19) . . ? C29' C28' H28' 110.0 . . ? N5' C28' C19' 121.6(2) . . ? N5' C28' H28' 110.0 . . ? N5' C28' C29' 117.1(2) . . ? C28' C29' C20' 88.0(2) . . ? C28' C29' C30' 110.4(2) . . ? C30' C29' C20' 109.7(2) . . ? N4' C29' C20' 117.2(2) . . ? N4' C29' C28' 117.5(2) . . ? N4' C29' C30' 111.8(2) . . ? C17' C30' H30' 109.9 . . ? C29' C30' C17' 105.0(2) . . ? C29' C30' H30' 109.9 . . ? C31' C30' C17' 111.7(2) . . ? C31' C30' C29' 110.2(2) . . ? C31' C30' H30' 109.9 . . ? C30' C31' H31' 119.8 . . ? C32' C31' C30' 120.4(3) . . ? C32' C31' H31' 119.8 . . ? C31' C32' H32' 117.6 . . ? C31' C32' N5' 124.7(3) . . ? N5' C32' H32' 117.6 . . ? H33C C33' H33D 107.5 . . ? C34' C33' H33C 108.4 . . ? C34' C33' H33D 108.4 . . ? N5' C33' H33C 108.4 . . ? N5' C33' H33D 108.4 . . ? N5' C33' C34' 115.3(4) . . ? C35' C34' C33' 123.5(5) . . ? C35' C34' C39' 116.3(5) . . ? C39' C34' C33' 120.2(5) . . ? C34' C35' H35' 117.8 . . ? C36' C35' C34' 124.3(5) . . ? C36' C35' H35' 117.8 . . ? C35' C36' H36' 121.2 . . ? C37' C36' C35' 117.6(6) . . ? C37' C36' H36' 121.2 . . ? C36' C37' H37' 118.1 . . ? C36' C37' C38' 123.9(7) . . ? C38' C37' H37' 118.1 . . ? C37' C38' H38' 120.7 . . ? C37' C38' C39' 118.6(6) . . ? C39' C38' H38' 120.7 . . ? C34' C39' C38' 119.3(6) . . ? C34' C39' H39' 120.4 . . ? C38' C39' H39' 120.4 . . ? C5' N1' C9' 124.0(2) . . ? C5' N1' C16' 118.73(19) . . ? C9' N1' C16' 113.81(18) . . ? O2' N2' C17' 119.2(2) . . ? O2' N2' O3' 123.8(3) . . ? O3' N2' C17' 117.0(2) . . ? C16' N3' C21' 111.5(2) . . ? C20' N3' C16' 113.54(19) . . ? C20' N3' C21' 115.4(2) . . ? O4' N4' C29' 118.3(3) . . ? O5' N4' C29' 119.0(3) . . ? O5' N4' O4' 122.6(3) . . ? C28' N5' C33' 114.7(3) . . ? C32' N5' C28' 118.8(2) . . ? C32' N5' C33' 123.4(3) . . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag C1 C2 C3 C4 -54.7(3) . . . . ? C1 C2 C3 C7 65.9(3) . . . . ? C1 C2 C3 C8 -172.2(3) . . . . ? C1 C6 C18 C17 160.8(2) . . . . ? C1 C6 C18 C19 -80.7(3) . . . . ? C2 C1 C6 C5 1.3(4) . . . . ? C2 C1 C6 C18 -178.5(2) . . . . ? C2 C3 C4 C5 49.0(3) . . . . ? C3 C4 C5 C6 -19.8(4) . . . . ? C3 C4 C5 N1 155.9(2) . . . . ? C4 C5 C6 C1 -7.2(4) . . . . ? C4 C5 C6 C18 172.6(2) . . . . ? C4 C5 N1 C9 17.7(3) . . . . ? C4 C5 N1 C16 174.8(2) . . . . ? C5 C6 C18 C17 -18.9(3) . . . . ? C5 C6 C18 C19 99.5(3) . . . . ? C6 C1 C2 C3 31.4(4) . . . . ? C6 C5 N1 C9 -166.6(2) . . . . ? C6 C5 N1 C16 -9.5(3) . . . . ? C6 C18 C19 C20 -98.7(2) . . . . ? C6 C18 C19 C28 166.79(19) . . . . ? C7 C3 C4 C5 -70.7(3) . . . . ? C8 C3 C4 C5 167.0(3) . . . . ? C9 C10 C11 C12 -1.5(5) . . . . ? C10 C9 C14 C13 -0.2(4) . . . . ? C10 C9 N1 C5 52.1(3) . . . . ? C10 C9 N1 C16 -106.0(3) . . . . ? C10 C11 C12 C13 0.2(5) . . . . ? C10 C11 C12 C15 -178.4(3) . . . . ? C11 C12 C13 C14 1.0(5) . . . . ? C12 C13 C14 C9 -1.0(5) . . . . ? C14 C9 C10 C11 1.5(4) . . . . ? C14 C9 N1 C5 -132.0(3) . . . . ? C14 C9 N1 C16 69.8(3) . . . . ? C15 C12 C13 C14 179.7(3) . . . . ? C16 C17 C18 C6 49.5(2) . . . . ? C16 C17 C18 C19 -73.4(2) . . . . ? C16 C17 C30 C29 70.5(2) . . . . ? C16 C17 C30 C31 -169.8(2) . . . . ? C16 C17 N2 O2 -128.3(2) . . . . ? C16 C17 N2 O3 53.3(3) . . . . ? C17 C16 N1 C5 42.5(3) . . . . ? C17 C16 N1 C9 -158.82(19) . . . . ? C17 C16 N3 C20 0.5(3) . . . . ? C17 C16 N3 C21 134.2(2) . . . . ? C17 C18 C19 C20 23.1(2) . . . . ? C17 C18 C19 C28 -71.5(2) . . . . ? C17 C30 C31 C32 -84.7(3) . . . . ? C18 C17 C30 C29 -49.1(2) . . . . ? C18 C17 C30 C31 70.6(3) . . . . ? C18 C17 N2 O2 -9.9(3) . . . . ? C18 C17 N2 O3 171.7(2) . . . . ? C18 C19 C20 C29 -83.7(2) . . . . ? C18 C19 C20 N3 37.4(3) . . . . ? C18 C19 C28 C29 81.0(2) . . . . ? C18 C19 C28 N5 -38.7(3) . . . . ? C19 C20 C29 C28 -28.60(17) . . . . ? C19 C20 C29 C30 82.7(2) . . . . ? C19 C20 C29 N4 -148.5(2) . . . . ? C19 C20 N3 C16 -51.5(3) . . . . ? C19 C20 N3 C21 175.6(2) . . . . ? C19 C28 C29 C20 28.26(17) . . . . ? C19 C28 C29 C30 -82.2(2) . . . . ? C19 C28 C29 N4 148.7(2) . . . . ? C19 C28 N5 C32 85.4(3) . . . . ? C19 C28 N5 C33 -67.3(3) . . . . ? C20 C19 C28 C29 -28.54(17) . . . . ? C20 C19 C28 N5 -148.2(2) . . . . ? C20 C29 C30 C17 -21.7(2) . . . . ? C20 C29 C30 C31 -142.9(2) . . . . ? C20 C29 N4 O4 98.2(3) . . . . ? C20 C29 N4 O5 -79.1(4) . . . . ? C21 C22 C23 C24 177.3(3) . . . . ? C21 C22 C27 C26 -178.4(3) . . . . ? C22 C21 N3 C16 169.6(2) . . . . ? C22 C21 N3 C20 -57.4(3) . . . . ? C22 C23 C24 C25 1.1(6) . . . . ? C23 C22 C27 C26 -0.9(5) . . . . ? C23 C24 C25 C26 -1.0(6) . . . . ? C24 C25 C26 C27 -0.1(6) . . . . ? C25 C26 C27 C22 1.1(6) . . . . ? C27 C22 C23 C24 -0.2(5) . . . . ? C28 C19 C20 C29 27.87(17) . . . . ? C28 C19 C20 N3 148.9(2) . . . . ? C28 C29 C30 C17 73.8(2) . . . . ? C28 C29 C30 C31 -47.3(3) . . . . ? C28 C29 N4 O4 -4.9(4) . . . . ? C28 C29 N4 O5 177.8(3) . . . . ? C29 C20 N3 C16 48.4(3) . . . . ? C29 C20 N3 C21 -84.5(3) . . . . ? C29 C28 N5 C32 -17.6(3) . . . . ? C29 C28 N5 C33 -170.2(2) . . . . ? C29 C30 C31 C32 32.0(3) . . . . ? C30 C17 C18 C6 171.17(19) . . . . ? C30 C17 C18 C19 48.3(2) . . . . ? C30 C17 N2 O2 112.5(2) . . . . ? C30 C17 N2 O3 -65.9(3) . . . . ? C30 C29 N4 O4 -133.8(3) . . . . ? C30 C29 N4 O5 48.9(4) . . . . ? C30 C31 C32 N5 -6.8(4) . . . . ? C31 C32 N5 C28 -1.5(4) . . . . ? C31 C32 N5 C33 150.4(3) . . . . ? C33 C34 C35 C36 179.9(4) . . . . ? C33 C34 C39 C38 -179.8(4) . . . . ? C34 C33 N5 C28 -49.0(3) . . . . ? C34 C33 N5 C32 158.7(2) . . . . ? C34 C35 C36 C37 -0.6(8) . . . . ? C35 C34 C39 C38 -0.9(6) . . . . ? C35 C36 C37 C38 -0.1(10) . . . . ? C36 C37 C38 C39 0.2(10) . . . . ? C37 C38 C39 C34 0.3(8) . . . . ? C39 C34 C35 C36 1.1(6) . . . . ? N1 C5 C6 C1 177.2(2) . . . . ? N1 C5 C6 C18 -3.0(4) . . . . ? N1 C9 C10 C11 177.3(2) . . . . ? N1 C9 C14 C13 -176.2(3) . . . . ? N1 C16 C17 C18 -61.4(2) . . . . ? N1 C16 C17 C30 176.87(18) . . . . ? N1 C16 C17 N2 60.4(2) . . . . ? N1 C16 N3 C20 122.3(2) . . . . ? N1 C16 N3 C21 -104.0(2) . . . . ? N2 C17 C18 C6 -69.0(2) . . . . ? N2 C17 C18 C19 168.17(18) . . . . ? N2 C17 C30 C29 -172.54(18) . . . . ? N2 C17 C30 C31 -52.8(3) . . . . ? N3 C16 C17 C18 61.9(2) . . . . ? N3 C16 C17 C30 -59.9(2) . . . . ? N3 C16 C17 N2 -176.37(18) . . . . ? N3 C16 N1 C5 -78.8(3) . . . . ? N3 C16 N1 C9 79.9(2) . . . . ? N3 C20 C29 C28 -146.5(2) . . . . ? N3 C20 C29 C30 -35.1(3) . . . . ? N3 C20 C29 N4 93.6(3) . . . . ? N3 C21 C22 C23 133.0(3) . . . . ? N3 C21 C22 C27 -49.6(3) . . . . ? N4 C29 C30 C17 -153.9(2) . . . . ? N4 C29 C30 C31 85.0(2) . . . . ? N5 C28 C29 C20 152.9(2) . . . . ? N5 C28 C29 C30 42.5(3) . . . . ? N5 C28 C29 N4 -86.7(3) . . . . ? N5 C33 C34 C35 106.0(3) . . . . ? N5 C33 C34 C39 -75.1(4) . . . . ? O1 C1 C2 C3 -150.4(3) . . . . ? O1 C1 C6 C5 -177.0(3) . . . . ? O1 C1 C6 C18 3.2(4) . . . . ? C1' C2' C3' C4' 55.8(3) . . . . ? C1' C2' C3' C7' -65.6(3) . . . . ? C1' C2' C3' C8' 174.3(3) . . . . ? C1' C6' C18' C17' -160.0(2) . . . . ? C1' C6' C18' C19' 82.2(3) . . . . ? C2' C1' C6' C5' 1.9(4) . . . . ? C2' C1' C6' C18' -179.8(2) . . . . ? C2' C3' C4' C5' -48.8(3) . . . . ? C3' C4' C5' C6' 20.5(4) . . . . ? C3' C4' C5' N1' -155.7(2) . . . . ? C4' C5' C6' C1' 4.6(4) . . . . ? C4' C5' C6' C18' -173.6(2) . . . . ? C4' C5' N1' C9' -15.9(4) . . . . ? C4' C5' N1' C16' -173.4(2) . . . . ? C5' C6' C18' C17' 18.3(3) . . . . ? C5' C6' C18' C19' -99.5(3) . . . . ? C6' C1' C2' C3' -33.9(4) . . . . ? C6' C5' N1' C9' 167.8(2) . . . . ? C6' C5' N1' C16' 10.3(4) . . . . ? C6' C18' C19' C20' 97.5(2) . . . . ? C6' C18' C19' C28' -167.5(2) . . . . ? C7' C3' C4' C5' 72.2(3) . . . . ? C8' C3' C4' C5' -167.8(3) . . . . ? C9' C10' C11' C12' 2.7(4) . . . . ? C10' C9' C14' C13' -1.7(4) . . . . ? C10' C9' N1' C5' -50.8(3) . . . . ? C10' C9' N1' C16' 107.7(3) . . . . ? C10' C11' C12' C13' -3.4(5) . . . . ? C10' C11' C12' C15' 175.8(3) . . . . ? C11' C12' C13' C14' 1.5(5) . . . . ? C12' C13' C14' C9' 1.1(5) . . . . ? C14' C9' C10' C11' -0.1(4) . . . . ? C14' C9' N1' C5' 134.4(3) . . . . ? C14' C9' N1' C16' -67.1(3) . . . . ? C15' C12' C13' C14' -177.7(3) . . . . ? C16' C17' C18' C6' -48.2(3) . . . . ? C16' C17' C18' C19' 74.4(2) . . . . ? C16' C17' C30' C29' -71.8(2) . . . . ? C16' C17' C30' C31' 168.8(2) . . . . ? C16' C17' N2' O2' 126.7(3) . . . . ? C16' C17' N2' O3' -54.2(3) . . . . ? C17' C16' N1' C5' -42.7(3) . . . . ? C17' C16' N1' C9' 157.6(2) . . . . ? C17' C16' N3' C20' 0.0(3) . . . . ? C17' C16' N3' C21' -132.5(2) . . . . ? C17' C18' C19' C20' -24.3(3) . . . . ? C17' C18' C19' C28' 70.7(2) . . . . ? C17' C30' C31' C32' 83.7(3) . . . . ? C18' C17' C30' C29' 48.1(3) . . . . ? C18' C17' C30' C31' -71.4(3) . . . . ? C18' C17' N2' O2' 8.3(3) . . . . ? C18' C17' N2' O3' -172.5(2) . . . . ? C18' C19' C20' C29' 84.5(2) . . . . ? C18' C19' C20' N3' -35.8(3) . . . . ? C18' C19' C28' C29' -81.9(2) . . . . ? C18' C19' C28' N5' 37.6(3) . . . . ? C19' C20' C29' C28' 28.01(19) . . . . ? C19' C20' C29' C30' -83.0(2) . . . . ? C19' C20' C29' N4' 148.1(2) . . . . ? C19' C20' N3' C16' 50.2(3) . . . . ? C19' C20' N3' C21' -179.2(2) . . . . ? C19' C28' C29' C20' -27.94(19) . . . . ? C19' C28' C29' C30' 82.4(2) . . . . ? C19' C28' C29' N4' -147.8(2) . . . . ? C19' C28' N5' C32' -87.9(3) . . . . ? C19' C28' N5' C33' 72.8(4) . . . . ? C20' C19' C28' C29' 28.15(19) . . . . ? C20' C19' C28' N5' 147.6(3) . . . . ? C20' C29' C30' C17' 22.7(3) . . . . ? C20' C29' C30' C31' 143.2(2) . . . . ? C20' C29' N4' O4' -91.2(4) . . . . ? C20' C29' N4' O5' 84.5(4) . . . . ? C21' C22' C23' C24' -175.2(3) . . . . ? C21' C22' C27' C26' 174.8(4) . . . . ? C22' C21' N3' C16' -167.5(2) . . . . ? C22' C21' N3' C20' 61.0(3) . . . . ? C22' C23' C24' C25' -0.2(7) . . . . ? C23' C22' C27' C26' -2.4(5) . . . . ? C23' C24' C25' C26' -1.4(7) . . . . ? C24' C25' C26' C27' 1.1(7) . . . . ? C25' C26' C27' C22' 0.8(7) . . . . ? C27' C22' C23' C24' 2.1(5) . . . . ? C28' C19' C20' C29' -27.43(19) . . . . ? C28' C19' C20' N3' -147.7(2) . . . . ? C28' C29' C30' C17' -72.7(2) . . . . ? C28' C29' C30' C31' 47.8(3) . . . . ? C28' C29' N4' O4' 11.7(4) . . . . ? C28' C29' N4' O5' -172.6(3) . . . . ? C29' C20' N3' C16' -49.3(3) . . . . ? C29' C20' N3' C21' 81.3(3) . . . . ? C29' C28' N5' C32' 14.9(4) . . . . ? C29' C28' N5' C33' 175.5(3) . . . . ? C29' C30' C31' C32' -32.7(4) . . . . ? C30' C17' C18' C6' -169.6(2) . . . . ? C30' C17' C18' C19' -46.9(3) . . . . ? C30' C17' N2' O2' -115.4(3) . . . . ? C30' C17' N2' O3' 63.7(3) . . . . ? C30' C29' N4' O4' 140.9(3) . . . . ? C30' C29' N4' O5' -43.4(4) . . . . ? C30' C31' C32' N5' 5.7(5) . . . . ? C31' C32' N5' C28' 4.4(5) . . . . ? C31' C32' N5' C33' -154.5(4) . . . . ? C33' C34' C35' C36' 178.7(5) . . . . ? C33' C34' C39' C38' -178.4(6) . . . . ? C34' C33' N5' C28' 175.2(4) . . . . ? C34' C33' N5' C32' -25.2(6) . . . . ? C34' C35' C36' C37' 0.0(11) . . . . ? C35' C34' C39' C38' 0.0(9) . . . . ? C35' C36' C37' C38' -0.5(13) . . . . ? C36' C37' C38' C39' 0.7(15) . . . . ? C37' C38' C39' C34' -0.5(12) . . . . ? C39' C34' C35' C36' 0.2(8) . . . . ? N1' C5' C6' C1' -179.3(2) . . . . ? N1' C5' C6' C18' 2.5(4) . . . . ? N1' C9' C10' C11' -174.9(2) . . . . ? N1' C9' C14' C13' 173.2(2) . . . . ? N1' C16' C17' C18' 60.5(3) . . . . ? N1' C16' C17' C30' -176.86(19) . . . . ? N1' C16' C17' N2' -61.4(2) . . . . ? N1' C16' N3' C20' -121.8(2) . . . . ? N1' C16' N3' C21' 105.7(2) . . . . ? N2' C17' C18' C6' 69.9(3) . . . . ? N2' C17' C18' C19' -167.43(19) . . . . ? N2' C17' C30' C29' 172.32(19) . . . . ? N2' C17' C30' C31' 52.8(3) . . . . ? N3' C16' C17' C18' -62.6(2) . . . . ? N3' C16' C17' C30' 60.0(3) . . . . ? N3' C16' C17' N2' 175.53(18) . . . . ? N3' C16' N1' C5' 78.3(3) . . . . ? N3' C16' N1' C9' -81.4(3) . . . . ? N3' C20' C29' C28' 146.0(2) . . . . ? N3' C20' C29' C30' 35.0(3) . . . . ? N3' C20' C29' N4' -93.8(3) . . . . ? N3' C21' C22' C23' -134.7(3) . . . . ? N3' C21' C22' C27' 48.1(4) . . . . ? N4' C29' C30' C17' 154.5(2) . . . . ? N4' C29' C30' C31' -85.0(3) . . . . ? N5' C28' C29' C20' -151.5(2) . . . . ? N5' C28' C29' C30' -41.2(3) . . . . ? N5' C28' C29' N4' 88.6(3) . . . . ? N5' C33' C34' C35' -82.4(6) . . . . ? N5' C33' C34' C39' 96.0(6) . . . . ? O1' C1' C2' C3' 148.1(3) . . . . ? O1' C1' C6' C5' 179.9(3) . . . . ? O1' C1' C6' C18' -1.8(4) . . . . ? _iucr_refine_instructions_details ; 201803150_tw.res created by SHELXL-2014/7 TITL CF solution in P21/c CELL 1.54184 11.804083 18.745044 31.258102 90 79.1361 90 ZERR 8 0.000141 0.000181 0.00037 0 0.0011 0 LATT 1 SYMM -X,0.5+Y,0.5-Z SFAC C H N O UNIT 312 312 40 40 DELU 0.001 0.001 C36' C37' DELU 0.001 0.001 C24 C25 ISOR 0.01 0.02 C36' C37' C38' C39' ISOR 0.01 0.02 C24 C25 ISOR 0.01 0.02 C33' L.S. 15 0 0 PLAN 20 SIZE 0.1 0.17 0.19 MPLA C9 C10 C11 C12 C13 C14 MPLA C22 C23 C24 C25 C26 C27 MPLA C34 C35 C36 C37 C38 C39 MPLA C9' C10' C11' C12' C13' C14' MPLA C22' C23' C24' C25' C26' C27' MPLA C34' C35' C36' C37' C38' C39' BOND $h CONF fmap 2 acta MERG 0 REM REM REM WGHT 0.090300 0.712600 BASF 0.34305 FVAR 3.04874 C1 1 0.335790 0.835778 0.455122 11.00000 0.04929 0.04654 = 0.04448 0.00117 -0.00136 -0.00370 C2 1 0.311167 0.757139 0.456575 11.00000 0.06831 0.05009 = 0.04956 0.00473 0.00412 -0.00848 AFIX 23 H2A 2 0.229718 0.749964 0.456711 11.00000 -1.20000 H2B 2 0.327468 0.737899 0.483580 11.00000 -1.20000 AFIX 0 C3 1 0.380911 0.715752 0.418581 11.00000 0.06743 0.04567 = 0.05197 0.00419 0.00134 -0.00041 C4 1 0.359633 0.750605 0.376639 11.00000 0.06628 0.04470 = 0.05066 -0.00494 -0.00888 -0.00182 AFIX 23 H4A 2 0.412874 0.730276 0.352246 11.00000 -1.20000 H4B 2 0.282071 0.738925 0.372860 11.00000 -1.20000 AFIX 0 C5 1 0.373225 0.830358 0.375357 11.00000 0.04157 0.04481 = 0.04123 -0.00279 -0.00582 -0.00095 C6 1 0.367908 0.869304 0.412766 11.00000 0.04216 0.04251 = 0.03885 -0.00028 -0.00508 -0.00073 C7 1 0.508582 0.718391 0.421358 11.00000 0.07291 0.07849 = 0.06682 0.01465 -0.00468 0.01923 AFIX 137 H7A 2 0.552168 0.690702 0.398101 11.00000 -1.50000 H7B 2 0.519039 0.699176 0.448817 11.00000 -1.50000 H7C 2 0.534826 0.766955 0.418903 11.00000 -1.50000 AFIX 0 C8 1 0.337725 0.639233 0.419794 11.00000 0.12956 0.04466 = 0.07067 0.00015 0.00077 -0.00775 AFIX 137 H8A 2 0.256634 0.639064 0.419338 11.00000 -1.50000 H8B 2 0.350926 0.616458 0.445923 11.00000 -1.50000 H8C 2 0.378347 0.613860 0.394886 11.00000 -1.50000 AFIX 0 C9 1 0.382101 0.829462 0.295950 11.00000 0.05198 0.04393 = 0.04425 -0.00360 -0.01509 0.00246 C10 1 0.277550 0.798599 0.292180 11.00000 0.05153 0.06023 = 0.06454 -0.00510 -0.01942 -0.00164 AFIX 43 H10 2 0.217078 0.798076 0.316032 11.00000 -1.20000 AFIX 0 C11 1 0.262948 0.769092 0.253802 11.00000 0.07398 0.05602 = 0.07971 -0.00608 -0.04115 0.00134 AFIX 43 H11 2 0.192931 0.747633 0.252053 11.00000 -1.20000 AFIX 0 C12 1 0.349543 0.770323 0.217531 11.00000 0.11949 0.05470 = 0.06406 -0.01201 -0.04454 0.00798 C13 1 0.453921 0.802528 0.220948 11.00000 0.10766 0.06094 = 0.04703 -0.01069 -0.00148 0.00486 AFIX 43 H13 2 0.513142 0.804631 0.196702 11.00000 -1.20000 AFIX 0 C14 1 0.470148 0.831257 0.259895 11.00000 0.06192 0.05487 = 0.05001 -0.00607 -0.00727 0.00192 AFIX 43 H14 2 0.540556 0.851925 0.261938 11.00000 -1.20000 AFIX 0 C15 1 0.332369 0.739161 0.174458 11.00000 0.20600 0.10483 = 0.08172 -0.03088 -0.07123 -0.00034 AFIX 137 H15A 2 0.345452 0.688612 0.174410 11.00000 -1.50000 H15B 2 0.385839 0.760801 0.151118 11.00000 -1.50000 H15C 2 0.254940 0.748335 0.170569 11.00000 -1.50000 AFIX 0 C16 1 0.402847 0.941575 0.333407 11.00000 0.03991 0.04754 = 0.03641 -0.00029 -0.00698 -0.00303 AFIX 13 H16 2 0.446519 0.955873 0.304860 11.00000 -1.20000 AFIX 0 C17 1 0.464271 0.970487 0.368599 11.00000 0.03613 0.04387 = 0.04327 0.00201 -0.00851 -0.00220 C18 1 0.394901 0.947621 0.412322 11.00000 0.04173 0.04442 = 0.03852 -0.00047 -0.01257 -0.00278 AFIX 13 H18 2 0.439580 0.957778 0.435051 11.00000 -1.20000 AFIX 0 C19 1 0.285981 0.994881 0.419811 11.00000 0.04190 0.04727 = 0.04022 -0.00466 -0.00843 -0.00104 AFIX 13 H19 2 0.218604 0.974634 0.439136 11.00000 -1.20000 AFIX 0 C20 1 0.263984 1.022186 0.375270 11.00000 0.04173 0.04573 = 0.04581 -0.00177 -0.01450 0.00287 AFIX 13 H20 2 0.186163 1.042090 0.378067 11.00000 -1.20000 AFIX 0 C21 1 0.258114 0.998933 0.298055 11.00000 0.05655 0.06511 = 0.04066 0.00520 -0.01567 -0.00290 AFIX 23 H21A 2 0.276184 0.961992 0.276097 11.00000 -1.20000 H21B 2 0.305464 1.040141 0.288057 11.00000 -1.20000 AFIX 0 C22 1 0.133571 1.019120 0.302235 11.00000 0.05879 0.05690 = 0.04641 -0.00637 -0.02504 0.00372 C23 1 0.102870 1.083328 0.285044 11.00000 0.08810 0.07352 = 0.06534 0.00450 -0.03196 0.01250 AFIX 43 H23 2 0.159501 1.115026 0.271916 11.00000 -1.20000 AFIX 0 C24 1 -0.013348 1.099607 0.287696 11.00000 0.10901 0.09153 = 0.08839 -0.00647 -0.04372 0.04417 AFIX 43 H24 2 -0.033791 1.142073 0.275765 11.00000 -1.20000 AFIX 0 C25 1 -0.097207 1.054701 0.307346 11.00000 0.07507 0.12195 = 0.09611 -0.02723 -0.04441 0.03524 AFIX 43 H25 2 -0.174352 1.066872 0.309178 11.00000 -1.20000 AFIX 0 C26 1 -0.068935 0.992048 0.324348 11.00000 0.05418 0.10189 = 0.11044 -0.01861 -0.02678 -0.00373 AFIX 43 H26 2 -0.126502 0.961276 0.337873 11.00000 -1.20000 AFIX 0 C27 1 0.046563 0.974054 0.321454 11.00000 0.05818 0.06455 = 0.09001 -0.00448 -0.02702 -0.00175 AFIX 43 H27 2 0.065443 0.930674 0.332737 11.00000 -1.20000 AFIX 0 C28 1 0.315518 1.073823 0.429895 11.00000 0.05174 0.04447 = 0.05107 -0.00519 -0.01733 0.00576 AFIX 13 H28 2 0.244118 1.100664 0.439739 11.00000 -1.20000 AFIX 0 C29 1 0.353233 1.081605 0.380601 11.00000 0.05494 0.03944 = 0.04939 0.00268 -0.02000 -0.00219 C30 1 0.475823 1.053339 0.365680 11.00000 0.05022 0.04288 = 0.04990 0.00495 -0.01366 -0.00643 AFIX 13 H30 2 0.504770 1.067559 0.335425 11.00000 -1.20000 AFIX 0 C31 1 0.553689 1.082129 0.394397 11.00000 0.04911 0.04942 = 0.06504 0.00534 -0.01846 -0.01223 AFIX 43 H31 2 0.630994 1.090672 0.382812 11.00000 -1.20000 AFIX 0 C32 1 0.512917 1.095596 0.436468 11.00000 0.06173 0.04654 = 0.06721 -0.00159 -0.03093 -0.00682 AFIX 43 H32 2 0.565829 1.108471 0.453690 11.00000 -1.20000 AFIX 0 C33 1 0.368196 1.073056 0.503026 11.00000 0.07965 0.06432 = 0.05675 0.00154 -0.02522 0.00236 AFIX 23 H33A 2 0.423739 1.094910 0.518228 11.00000 -1.20000 H33B 2 0.373901 1.021751 0.506066 11.00000 -1.20000 AFIX 0 C34 1 0.249667 1.096460 0.523987 11.00000 0.07878 0.06293 = 0.04698 -0.00711 -0.01892 0.00451 C35 1 0.164075 1.046573 0.533812 11.00000 0.09552 0.08012 = 0.09229 -0.00019 -0.00494 -0.00263 AFIX 43 H35 2 0.180494 0.998824 0.527333 11.00000 -1.20000 AFIX 0 C36 1 0.053138 1.066372 0.553317 11.00000 0.08307 0.14373 = 0.13852 0.02030 0.01423 -0.00657 AFIX 43 H36 2 -0.004194 1.031855 0.559550 11.00000 -1.20000 AFIX 0 C37 1 0.027437 1.135778 0.563408 11.00000 0.11469 0.16410 = 0.10914 0.02315 0.02650 0.05215 AFIX 43 H37 2 -0.047003 1.149011 0.576457 11.00000 -1.20000 AFIX 0 C38 1 0.112426 1.185591 0.554105 11.00000 0.15579 0.10362 = 0.11306 -0.01360 0.00700 0.05294 AFIX 43 H38 2 0.095946 1.233222 0.560932 11.00000 -1.20000 AFIX 0 C39 1 0.224206 1.165782 0.534387 11.00000 0.12124 0.07572 = 0.09011 -0.01017 -0.01131 0.00999 AFIX 43 H39 2 0.281615 1.200281 0.528334 11.00000 -1.20000 AFIX 0 N1 3 0.399042 0.863779 0.335434 11.00000 0.04881 0.04624 = 0.03746 -0.00318 -0.00699 -0.00294 N2 3 0.586171 0.940482 0.359913 11.00000 0.03792 0.05392 = 0.05630 0.00014 -0.00906 -0.00410 N3 3 0.288368 0.972975 0.339170 11.00000 0.04000 0.05049 = 0.04012 -0.00240 -0.01195 -0.00128 N4 3 0.338520 1.153387 0.361325 11.00000 0.07014 0.04513 = 0.06960 0.00502 -0.02875 0.00051 N5 3 0.398269 1.091848 0.456293 11.00000 0.06099 0.04967 = 0.05108 -0.00735 -0.02272 -0.00088 O1 4 0.326469 0.871177 0.488578 11.00000 0.08899 0.05730 = 0.03835 -0.00195 -0.00858 -0.00999 O2 4 0.621991 0.911083 0.388974 11.00000 0.05416 0.08850 = 0.07378 0.00927 -0.02106 0.01558 O3 4 0.642892 0.949427 0.323533 11.00000 0.04716 0.10831 = 0.06710 0.00810 0.00067 0.00354 O4 4 0.291586 1.199732 0.384315 11.00000 0.15099 0.05382 = 0.10306 0.00209 -0.02524 0.03349 O5 4 0.370659 1.161534 0.322816 11.00000 0.16454 0.07263 = 0.08371 0.02883 -0.01543 0.02186 C1' 1 0.931337 0.337846 0.451548 11.00000 0.05544 0.05935 = 0.04855 0.00584 -0.01059 -0.00435 C2' 1 0.960876 0.260506 0.454743 11.00000 0.06281 0.06460 = 0.04972 0.01390 -0.01270 -0.00345 AFIX 23 H2'A 2 0.915121 0.240982 0.481193 11.00000 -1.20000 H2'B 2 1.041435 0.256548 0.457055 11.00000 -1.20000 AFIX 0 C3' 1 0.940256 0.216104 0.416150 11.00000 0.05814 0.05259 = 0.05242 0.01197 -0.00716 -0.00165 C4' 1 1.009437 0.250726 0.374668 11.00000 0.06003 0.04966 = 0.05331 0.00680 -0.00075 0.00222 AFIX 23 H4'A 2 1.090847 0.241413 0.373370 11.00000 -1.20000 H4'B 2 0.987402 0.228529 0.349421 11.00000 -1.20000 AFIX 0 C5' 1 0.991324 0.330476 0.372387 11.00000 0.04232 0.04917 = 0.04687 0.00764 -0.00489 -0.00119 C6' 1 0.951063 0.369936 0.408292 11.00000 0.04656 0.04830 = 0.04439 0.00453 -0.00366 -0.00276 C7' 1 0.812926 0.213234 0.414717 11.00000 0.06642 0.06566 = 0.06642 0.01337 -0.01084 -0.01342 AFIX 137 H7'A 2 0.771594 0.193138 0.441388 11.00000 -1.50000 H7'B 2 0.801270 0.184143 0.390644 11.00000 -1.50000 H7'C 2 0.785126 0.260601 0.411212 11.00000 -1.50000 AFIX 0 C8' 1 0.984143 0.139811 0.420094 11.00000 0.09255 0.05516 = 0.07425 0.01629 -0.00632 0.00631 AFIX 137 H8'A 2 1.064606 0.141064 0.421591 11.00000 -1.50000 H8'B 2 0.973625 0.112564 0.395131 11.00000 -1.50000 H8'C 2 0.941665 0.118056 0.446027 11.00000 -1.50000 AFIX 0 C9' 1 1.073213 0.326726 0.293315 11.00000 0.04391 0.04633 = 0.04805 0.00382 0.00245 -0.00203 C10' 1 1.180694 0.296788 0.292647 11.00000 0.04671 0.05816 = 0.06488 0.00740 -0.00006 -0.00031 AFIX 43 H10' 2 1.212053 0.294978 0.317779 11.00000 -1.20000 AFIX 0 C11' 1 1.241107 0.269289 0.253248 11.00000 0.05585 0.05598 = 0.09174 0.00224 0.01949 0.00421 AFIX 43 H11' 2 1.311903 0.247248 0.252806 11.00000 -1.20000 AFIX 0 C12' 1 1.199348 0.273800 0.215386 11.00000 0.08854 0.05800 = 0.06173 -0.00974 0.01517 -0.00273 C13' 1 1.091362 0.303292 0.217140 11.00000 0.10165 0.06798 = 0.05551 -0.00931 -0.01561 -0.00333 AFIX 43 H13' 2 1.060939 0.305763 0.191815 11.00000 -1.20000 AFIX 0 C14' 1 1.027794 0.329062 0.255368 11.00000 0.06085 0.05569 = 0.05711 -0.00125 -0.01029 -0.00157 AFIX 43 H14' 2 0.954718 0.347988 0.255888 11.00000 -1.20000 AFIX 0 C15' 1 1.271652 0.247820 0.172993 11.00000 0.14830 0.09322 = 0.08739 -0.02282 0.03962 0.00171 AFIX 137 H15D 2 1.283176 0.197268 0.174609 11.00000 -1.50000 H15E 2 1.345028 0.271554 0.168086 11.00000 -1.50000 H15F 2 1.232566 0.258175 0.149420 11.00000 -1.50000 AFIX 0 C16' 1 1.006874 0.439104 0.328227 11.00000 0.04369 0.04858 = 0.04333 0.00551 -0.00804 0.00185 AFIX 13 H16' 2 0.997020 0.451640 0.298711 11.00000 -1.20000 AFIX 0 C17' 1 0.904754 0.468240 0.360570 11.00000 0.03962 0.04980 = 0.04823 0.00290 -0.00873 0.00199 C18' 1 0.921358 0.447316 0.405923 11.00000 0.04389 0.05053 = 0.04590 0.00216 -0.00352 0.00216 AFIX 13 H18' 2 0.850019 0.457036 0.426780 11.00000 -1.20000 AFIX 0 C19' 1 1.017649 0.497514 0.415625 11.00000 0.05084 0.05653 = 0.04875 0.00227 -0.01378 0.00180 AFIX 13 H19' 2 1.061065 0.479546 0.437184 11.00000 -1.20000 AFIX 0 C20' 1 1.092633 0.523302 0.372060 11.00000 0.04280 0.05199 = 0.05650 0.00452 -0.01217 -0.00180 AFIX 13 H20' 2 1.165204 0.544339 0.376867 11.00000 -1.20000 AFIX 0 C21' 1 1.185569 0.499132 0.295865 11.00000 0.05033 0.06352 = 0.06192 0.01116 -0.00396 -0.00257 AFIX 23 H21C 2 1.148406 0.540167 0.285569 11.00000 -1.20000 H21D 2 1.190736 0.462162 0.273868 11.00000 -1.20000 AFIX 0 C22' 1 1.305542 0.519885 0.300714 11.00000 0.04832 0.05789 = 0.06117 -0.00213 0.00458 -0.00090 C23' 1 1.352268 0.583074 0.282553 11.00000 0.07719 0.07868 = 0.07777 0.01175 -0.00204 -0.02001 AFIX 43 H23' 2 1.307227 0.613817 0.269440 11.00000 -1.20000 AFIX 0 C24' 1 1.465660 0.601088 0.283689 11.00000 0.09225 0.11375 = 0.09505 0.00158 0.00497 -0.05639 AFIX 43 H24' 2 1.496203 0.643671 0.271279 11.00000 -1.20000 AFIX 0 C25' 1 1.533204 0.556094 0.303148 11.00000 0.05418 0.14228 = 0.09527 -0.02827 0.00322 -0.02645 AFIX 43 H25' 2 1.609765 0.567374 0.303465 11.00000 -1.20000 AFIX 0 C26' 1 1.486121 0.495388 0.321723 11.00000 0.05460 0.11960 = 0.12375 -0.01748 -0.02013 0.01472 AFIX 43 H26' 2 1.530827 0.465199 0.335350 11.00000 -1.20000 AFIX 0 C27' 1 1.373526 0.476959 0.321026 11.00000 0.05510 0.06901 = 0.11563 0.00369 -0.01545 0.00537 AFIX 43 H27' 2 1.343230 0.435033 0.334443 11.00000 -1.20000 AFIX 0 C28' 1 0.974154 0.575703 0.422919 11.00000 0.05832 0.05139 = 0.05935 -0.00403 -0.01579 0.00069 AFIX 13 H28' 2 1.030408 0.604294 0.434844 11.00000 -1.20000 AFIX 0 C29' 1 0.997210 0.581615 0.373380 11.00000 0.05173 0.04443 = 0.06092 0.00474 -0.01095 0.00101 C30' 1 0.896028 0.551030 0.355162 11.00000 0.05170 0.04814 = 0.05204 0.00429 -0.01165 0.00534 AFIX 13 H30' 2 0.904283 0.563203 0.324238 11.00000 -1.20000 AFIX 0 C31' 1 0.783945 0.579921 0.380055 11.00000 0.05569 0.06039 = 0.06088 0.00158 -0.01369 0.01596 AFIX 43 H31' 2 0.722437 0.587351 0.365859 11.00000 -1.20000 AFIX 0 C32' 1 0.772203 0.594948 0.422340 11.00000 0.06022 0.07522 = 0.06780 -0.00701 -0.00950 0.02288 AFIX 43 H32' 2 0.699540 0.608610 0.437096 11.00000 -1.20000 AFIX 0 C33' 1 0.839846 0.579963 0.492336 11.00000 0.10576 0.18200 = 0.06416 -0.00922 -0.01285 0.03073 AFIX 23 H33C 2 0.898264 0.605852 0.504071 11.00000 -1.20000 H33D 2 0.850374 0.529604 0.497565 11.00000 -1.20000 AFIX 0 C34' 1 0.725188 0.601713 0.516519 11.00000 0.09441 0.09610 = 0.05713 -0.00380 -0.00013 0.00520 C35' 1 0.697735 0.670583 0.529433 11.00000 0.11959 0.09399 = 0.10607 -0.01625 -0.00940 -0.01728 AFIX 43 H35' 2 0.755194 0.704993 0.523041 11.00000 -1.20000 AFIX 0 C36' 1 0.591823 0.691875 0.551007 11.00000 0.14440 0.12487 = 0.12891 -0.04299 0.00411 0.02035 AFIX 43 H36' 2 0.577405 0.739235 0.559102 11.00000 -1.20000 AFIX 0 C37' 1 0.510951 0.643168 0.559944 11.00000 0.13748 0.18414 = 0.15047 -0.03386 0.04489 -0.00084 AFIX 43 H37' 2 0.438681 0.657287 0.574842 11.00000 -1.20000 AFIX 0 C38' 1 0.526337 0.574325 0.548879 11.00000 0.15565 0.17169 = 0.18915 0.02701 0.03563 -0.06921 AFIX 43 H38' 2 0.466026 0.541875 0.555665 11.00000 -1.20000 AFIX 0 C39' 1 0.637230 0.551820 0.526456 11.00000 0.18282 0.09741 = 0.15794 0.01431 -0.00837 -0.02720 AFIX 43 H39' 2 0.650427 0.504266 0.518589 11.00000 -1.20000 AFIX 0 N1' 3 1.011077 0.360994 0.331686 11.00000 0.04567 0.04531 = 0.04366 0.00299 -0.00311 0.00159 N2' 3 0.796714 0.436730 0.348704 11.00000 0.04321 0.06055 = 0.06108 -0.00011 -0.00937 0.00155 N3' 3 1.112581 0.472980 0.336586 11.00000 0.04097 0.05072 = 0.04936 0.00757 -0.00525 -0.00130 N4' 3 1.034409 0.652983 0.353760 11.00000 0.06724 0.04785 = 0.07642 0.00269 -0.00859 -0.00087 N5' 3 0.859179 0.591731 0.445569 11.00000 0.06602 0.06008 = 0.05618 -0.00723 -0.01052 0.00750 O1' 4 0.895045 0.373539 0.484050 11.00000 0.09640 0.06975 = 0.04497 0.00230 -0.00246 0.00171 O2' 4 0.728674 0.406245 0.376314 11.00000 0.05608 0.10362 = 0.08740 0.01356 -0.00696 -0.02234 O3' 4 0.783217 0.444812 0.311004 11.00000 0.06223 0.10941 = 0.07046 -0.00018 -0.02499 -0.00948 O4' 4 1.061959 0.698259 0.376960 11.00000 0.16260 0.06344 = 0.11105 -0.00718 -0.01639 -0.03324 O5' 4 1.041888 0.661171 0.315305 11.00000 0.18140 0.07639 = 0.08263 0.02858 -0.02809 -0.03593 HKLF 5 REM CF solution in P21/c REM R1 = 0.0516 for 9893 Fo > 4sig(Fo) and 0.0596 for all 11515 data REM 890 parameters refined using 44 restraints END WGHT 0.0903 0.7125 REM Highest difference peak 0.381, deepest hole -0.274, 1-sigma level 0.041 Q1 1 0.8535 0.6388 0.4869 11.00000 0.05 0.38 Q2 1 0.6930 0.5675 0.3645 11.00000 0.05 0.30 Q3 1 0.5740 0.5633 0.5880 11.00000 0.05 0.24 Q4 1 0.5618 0.6228 0.5886 11.00000 0.05 0.24 Q5 1 0.6574 1.0777 0.3762 11.00000 0.05 0.23 Q6 1 0.4335 0.8060 0.2835 11.00000 0.05 0.23 Q7 1 0.1724 1.1305 0.5085 11.00000 0.05 0.23 Q8 1 1.5155 0.4409 0.3304 11.00000 0.05 0.22 Q9 1 1.0966 0.3619 0.1660 11.00000 0.05 0.21 Q10 1 1.6920 0.5019 0.2978 11.00000 0.05 0.21 Q11 1 1.3088 0.4394 0.3543 11.00000 0.05 0.21 Q12 1 -0.0909 0.9409 0.3315 11.00000 0.05 0.20 Q13 1 0.3864 0.8057 0.2098 11.00000 0.05 0.20 Q14 1 0.0829 0.9404 0.3577 11.00000 0.05 0.19 Q15 1 -0.2228 1.0183 0.3725 11.00000 0.05 0.19 Q16 1 -0.2036 0.9718 0.3356 11.00000 0.05 0.18 Q17 1 1.1224 0.3328 0.1269 11.00000 0.05 0.18 Q18 1 0.5010 0.6640 0.6269 11.00000 0.05 0.18 Q19 1 0.3804 1.1413 0.4903 11.00000 0.05 0.18 Q20 1 1.6126 0.4739 0.3379 11.00000 0.05 0.18 REM The information below was added by Olex2. REM REM R1 = 0.0516 for 9893 Fo > 4sig(Fo) and 0.0596 for all 11515 data REM n/a parameters refined using n/a restraints REM Highest difference peak 0.38, deepest hole -0.27 REM Mean Shift 0, Max Shift 0.000. REM +++ Tabular Listing of Refinement Information +++ REM R1_all = 0.0596 REM R1_gt = 0.0516 REM wR_ref = 0.1465 REM GOOF = 1.038 REM Shift_max = 0.000 REM Shift_mean = 0 REM Reflections_all = 11515 REM Reflections_gt = 9893 REM Parameters = n/a REM Hole = -0.27 REM Peak = 0.38 REM Flack = n/a ; _olex2_submission_special_instructions 'No special instructions were received' loop_ _twin_individual_id _twin_individual_mass_fraction_refined 1 0.6569(10) 2 0.3431(10) ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_201809362 _database_code_depnum_ccdc_archive 'CCDC 1947689' loop_ _audit_author_name _audit_author_address 'Qilin Wang' ;Henan University China ; _audit_update_record ; 2019-08-17 deposited with the CCDC. 2019-12-17 downloaded from the CCDC. ; _audit_creation_date 2018-09-11 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic ? _chemical_formula_moiety 'C45 H39 Cl2 N3 O' _chemical_formula_sum 'C45 H39 Cl2 N3 O' _chemical_formula_weight 708.69 _chemical_melting_point ? _chemical_oxdiff_formula C15H15O3 loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' Cl Cl 0.3639 0.7018 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system monoclinic _space_group_IT_number 14 _space_group_name_H-M_alt 'P 1 21/n 1' _space_group_name_Hall '-P 2yn' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x+1/2, y+1/2, -z+1/2' '-x, -y, -z' 'x-1/2, -y-1/2, z-1/2' _cell_length_a 13.58053(11) _cell_length_b 20.7753(2) _cell_length_c 29.2921(3) _cell_angle_alpha 90 _cell_angle_beta 102.8973(9) _cell_angle_gamma 90 _cell_volume 8055.96(13) _cell_formula_units_Z 8 _cell_measurement_reflns_used 11310 _cell_measurement_temperature 293(2) _cell_measurement_theta_max 70.8680 _cell_measurement_theta_min 3.9470 _shelx_estimated_absorpt_T_max ? _shelx_estimated_absorpt_T_min ? _exptl_absorpt_coefficient_mu 1.725 _exptl_absorpt_correction_T_max 1.00000 _exptl_absorpt_correction_T_min 0.80582 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. ; _exptl_absorpt_special_details ? _exptl_crystal_colour ? _exptl_crystal_density_diffrn 1.169 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_F_000 2976 _exptl_crystal_size_max ? _exptl_crystal_size_mid ? _exptl_crystal_size_min ? _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0322 _diffrn_reflns_av_unetI/netI 0.0341 _diffrn_reflns_Laue_measured_fraction_full 1.000 _diffrn_reflns_Laue_measured_fraction_max 1.000 _diffrn_reflns_limit_h_max 16 _diffrn_reflns_limit_h_min -13 _diffrn_reflns_limit_k_max 24 _diffrn_reflns_limit_k_min -22 _diffrn_reflns_limit_l_max 34 _diffrn_reflns_limit_l_min -34 _diffrn_reflns_number 37627 _diffrn_reflns_point_group_measured_fraction_full 1.000 _diffrn_reflns_point_group_measured_fraction_max 1.000 _diffrn_reflns_theta_full 67.075 _diffrn_reflns_theta_max 67.075 _diffrn_reflns_theta_min 3.352 _diffrn_ambient_temperature 293(2) _diffrn_detector 'CCD plate' _diffrn_detector_area_resol_mean 16.2312 _diffrn_detector_type Eos _diffrn_measured_fraction_theta_full 1.000 _diffrn_measured_fraction_theta_max 1.000 _diffrn_measurement_details ; #__ type_ start__ end____ width___ exp.time_ 1 omega -86.00 -33.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 -180.0000 106 #__ type_ start__ end____ width___ exp.time_ 2 omega -92.00 -66.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 -30.0000 52 #__ type_ start__ end____ width___ exp.time_ 3 omega -24.00 35.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 57.0000 -180.0000 118 #__ type_ start__ end____ width___ exp.time_ 4 omega -87.00 -34.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - -33.5000 178.0000 -60.0000 106 #__ type_ start__ end____ width___ exp.time_ 5 omega -1.00 109.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 19.0000 -150.0000 220 #__ type_ start__ end____ width___ exp.time_ 6 omega -14.00 34.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -57.0000 60.0000 96 #__ type_ start__ end____ width___ exp.time_ 7 omega 77.00 103.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 90.0000 52 #__ type_ start__ end____ width___ exp.time_ 8 omega 59.00 93.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 0.0000 68 #__ type_ start__ end____ width___ exp.time_ 9 omega 23.00 71.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 57.0000 -90.0000 96 #__ type_ start__ end____ width___ exp.time_ 10 omega 58.00 101.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 150.0000 86 #__ type_ start__ end____ width___ exp.time_ 11 omega 82.00 109.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 120.0000 54 #__ type_ start__ end____ width___ exp.time_ 12 omega 39.00 67.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 -99.0000 0.0000 56 #__ type_ start__ end____ width___ exp.time_ 13 omega 74.00 110.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 178.0000 -30.0000 72 #__ type_ start__ end____ width___ exp.time_ 14 omega 77.00 104.00 0.5000 4.5000 omega____ theta____ kappa____ phi______ frames - 36.4734 57.0000 -90.0000 54 #__ type_ start__ end____ width___ exp.time_ 15 omega 97.00 156.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 45.0000 150.0000 118 #__ type_ start__ end____ width___ exp.time_ 16 omega 39.00 98.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 -60.0000 118 #__ type_ start__ end____ width___ exp.time_ 17 omega 65.00 108.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -94.0000 30.0000 86 #__ type_ start__ end____ width___ exp.time_ 18 omega 117.00 157.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 111.0000 90.0000 80 #__ type_ start__ end____ width___ exp.time_ 19 omega 42.00 80.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -30.0000 120.0000 76 #__ type_ start__ end____ width___ exp.time_ 20 omega 53.00 79.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 -180.0000 52 #__ type_ start__ end____ width___ exp.time_ 21 omega 94.00 160.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 61.0000 90.0000 132 #__ type_ start__ end____ width___ exp.time_ 22 omega 41.00 99.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -45.0000 0.0000 116 #__ type_ start__ end____ width___ exp.time_ 23 omega 74.00 164.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 15.0000 60.0000 180 #__ type_ start__ end____ width___ exp.time_ 24 omega 37.00 109.00 0.5000 27.5000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 -30.0000 144 ; _diffrn_measurement_device 'four-circle diffractometer' _diffrn_measurement_device_type 'Xcalibur, Eos, Gemini' _diffrn_measurement_method '\w scans' _diffrn_orient_matrix_UB_11 0.0564917000 _diffrn_orient_matrix_UB_12 -0.0647875000 _diffrn_orient_matrix_UB_13 0.0041741000 _diffrn_orient_matrix_UB_21 -0.0773419000 _diffrn_orient_matrix_UB_22 -0.0255756000 _diffrn_orient_matrix_UB_23 -0.0428702000 _diffrn_orient_matrix_UB_31 0.0661083000 _diffrn_orient_matrix_UB_32 0.0254026000 _diffrn_orient_matrix_UB_33 -0.0325096000 _diffrn_radiation_monochromator graphite _diffrn_radiation_probe x-ray _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54184 _diffrn_source 'Enhance (Cu) X-ray Source' _reflns_Friedel_coverage 0.000 _reflns_Friedel_fraction_full . _reflns_Friedel_fraction_max . _reflns_number_gt 10018 _reflns_number_total 14381 _reflns_odcompleteness_completeness 99.95 _reflns_odcompleteness_iscentric 1 _reflns_odcompleteness_theta 66.97 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_collection ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_data_reduction ; CrysAlisPro, Agilent Technologies, Version 1.171.37.35 (release 13-08-2014 CrysAlis171 .NET) (compiled Aug 13 2014,18:06:01) ; _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution ; Superflip (Palatinus & Chapuis, 2007;Palatinus & van der Lee, 2008; Palatinus et al., 2012) ; _refine_diff_density_max 3.290 _refine_diff_density_min -0.339 _refine_diff_density_rms 0.170 _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.431 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 929 _refine_ls_number_reflns 14381 _refine_ls_number_restraints 0 _refine_ls_R_factor_all 0.1448 _refine_ls_R_factor_gt 0.1225 _refine_ls_restrained_S_all 1.431 _refine_ls_shift/su_max 0.546 _refine_ls_shift/su_mean 0.010 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.2000P)^2^] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.3481 _refine_ls_wR_factor_ref 0.3780 _refine_special_details ? _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups, All C(H,H,H,H) groups At 1.5 times of: All C(H,H,H) groups 2. Uiso/Uaniso restraints and constraints Uanis(C36) = Uanis(C36A) Uanis(C36') = Uanis(C1A) 3. Others Sof(H35C)=Sof(H35D)=Sof(C36A)=Sof(H36C)=Sof(H36D)=Sof(H37C)=Sof(H37D)=1-FVAR(1) Sof(H35A)=Sof(H35B)=Sof(C36)=Sof(H36A)=Sof(H36B)=Sof(H37A)=Sof(H37B)=FVAR(1) Sof(C1A)=Sof(H1AA)=Sof(H1AB)=Sof(H35G)=Sof(H35H)=Sof(H37G)=Sof(H37H)=1-FVAR(2) Sof(H35E)=Sof(H35F)=Sof(C36')=Sof(H36E)=Sof(H36F)=Sof(H37E)=Sof(H37F)=FVAR(2) 4.a Ternary CH refined with riding coordinates: C7(H7), C8(H8), C9(H9), C25(H25), C7'(H7'), C8'(H8'), C9'(H9'), C25'(H25') 4.b Secondary CH2 refined with riding coordinates: C10(H10A,H10B), C26(H26A,H26B), C35(H35A,H35B), C35(H35C,H35D), C36(H36A, H36B), C36A(H36C,H36D), C37(H37A,H37B), C37(H37C,H37D), C1A(H1AA,H1AB), C10'(H10C,H10D), C26'(H26C,H26D), C35'(H35E,H35F), C35'(H35G,H35H), C36'(H36E, H36F), C37'(H37E,H37F), C37'(H37G,H37H) 4.c Aromatic/amide H refined with riding coordinates: C2(H2), C3(H3), C5(H5), C12(H12), C13(H13), C14(H14), C15(H15), C16(H16), C18(H18), C19(H19), C21(H21), C23(H23), C24(H24), C28(H28), C29(H29), C30(H30), C31(H31), C32(H32), C40(H40), C41(H41), C43(H43), C44(H44), C2'(H2'), C3'(H3'), C5'(H5'), C12'(H12'), C13'(H13'), C14'(H14'), C15'(H15'), C16'(H16'), C18'(H18'), C19'(H19'), C21'(H21'), C23'(H23'), C24'(H24'), C28'(H28'), C29'(H29'), C30'(H30'), C31'(H31'), C32'(H32'), C40'(H40'), C41'(H41'), C43'(H43'), C44'(H44') 4.d Idealised Me refined as rotating group: C45(H45A,H45B,H45C), C45'(H45D,H45E,H45F) ; _atom_sites_solution_hydrogens geom _atom_sites_solution_primary iterative _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C1 C 0.1882(2) 0.7234(2) 0.42867(13) 0.0486(8) Uani 1 1 d . . . . . C2 C 0.1256(3) 0.6859(2) 0.45040(14) 0.0581(10) Uani 1 1 d . . . . . H2 H 0.0788 0.7061 0.4644 0.070 Uiso 1 1 calc R . . . . C3 C 0.1324(3) 0.6212(3) 0.45124(16) 0.0650(12) Uani 1 1 d . . . . . H3 H 0.0911 0.5971 0.4661 0.078 Uiso 1 1 calc R . . . . C4 C 0.2011(3) 0.5905(2) 0.42992(16) 0.0629(11) Uani 1 1 d . . . . . C5 C 0.2655(3) 0.6260(2) 0.40923(14) 0.0531(9) Uani 1 1 d . . . . . H5 H 0.3127 0.6052 0.3957 0.064 Uiso 1 1 calc R . . . . C6 C 0.2597(3) 0.6925(2) 0.40866(13) 0.0476(8) Uani 1 1 d . . . . . C7 C 0.3289(2) 0.73337(18) 0.38660(13) 0.0456(8) Uani 1 1 d . . . . . H7 H 0.3539 0.7079 0.3634 0.055 Uiso 1 1 calc R . . . . C8 C 0.2700(3) 0.7912(2) 0.36276(14) 0.0510(9) Uani 1 1 d . . . . . H8 H 0.3172 0.8183 0.3504 0.061 Uiso 1 1 calc R . . . . C9 C 0.2380(3) 0.8289(2) 0.40182(14) 0.0528(9) Uani 1 1 d . . . . . H9 H 0.1965 0.8654 0.3877 0.063 Uiso 1 1 calc R . . . . C10 C 0.1253(3) 0.8247(3) 0.45684(16) 0.0623(11) Uani 1 1 d . . . . . H10A H 0.1506 0.8684 0.4608 0.075 Uiso 1 1 calc R . . . . H10B H 0.1407 0.8043 0.4874 0.075 Uiso 1 1 calc R . . . . C11 C 0.0116(3) 0.8271(2) 0.43948(14) 0.0515(9) Uani 1 1 d . . . . . C12 C -0.0386(3) 0.8024(3) 0.39712(16) 0.0683(12) Uani 1 1 d . . . . . H12 H -0.0020 0.7831 0.3776 0.082 Uiso 1 1 calc R . . . . C13 C -0.1426(3) 0.8060(3) 0.38309(17) 0.0787(15) Uani 1 1 d . . . . . H13 H -0.1748 0.7890 0.3543 0.094 Uiso 1 1 calc R . . . . C14 C -0.1984(3) 0.8339(3) 0.41079(18) 0.0741(14) Uani 1 1 d . . . . . H14 H -0.2682 0.8368 0.4009 0.089 Uiso 1 1 calc R . . . . C15 C -0.1501(4) 0.8576(3) 0.45338(19) 0.0737(13) Uani 1 1 d . . . . . H15 H -0.1876 0.8759 0.4730 0.088 Uiso 1 1 calc R . . . . C16 C -0.0448(3) 0.8548(2) 0.46777(16) 0.0620(10) Uani 1 1 d . . . . . H16 H -0.0127 0.8717 0.4967 0.074 Uiso 1 1 calc R . . . . C17 C 0.2678(3) 0.7747(2) 0.25646(14) 0.0572(10) Uani 1 1 d . . . . . C18 C 0.3335(4) 0.7466(3) 0.23233(16) 0.0702(12) Uani 1 1 d . . . . . H18 H 0.3426 0.7022 0.2337 0.084 Uiso 1 1 calc R . . . . C19 C 0.3864(4) 0.7837(3) 0.20598(17) 0.0730(13) Uani 1 1 d . . . . . H19 H 0.4313 0.7644 0.1904 0.088 Uiso 1 1 calc R . . . . C20 C 0.3710(4) 0.8491(3) 0.20344(16) 0.0700(12) Uani 1 1 d . . . . . C21 C 0.3022(4) 0.8778(2) 0.22416(15) 0.0647(11) Uani 1 1 d . . . . . H21 H 0.2904 0.9218 0.2205 0.078 Uiso 1 1 calc R . . . . C22 C 0.2492(3) 0.8417(2) 0.25086(15) 0.0591(10) Uani 1 1 d . . . . . C23 C 0.1668(4) 0.8681(3) 0.26950(17) 0.0735(13) Uani 1 1 d . . . . . H23 H 0.1405 0.9082 0.2593 0.088 Uiso 1 1 calc R . . . . C24 C 0.1286(4) 0.8364(3) 0.30056(17) 0.0745(14) Uani 1 1 d . . . . . H24 H 0.0709 0.8512 0.3093 0.089 Uiso 1 1 calc R . . . . C25 C 0.1808(3) 0.7752(2) 0.32171(15) 0.0601(10) Uani 1 1 d . . . . . H25 H 0.1322 0.7482 0.3331 0.072 Uiso 1 1 calc R . . . . C26 C 0.2138(4) 0.6709(2) 0.28448(17) 0.0753(14) Uani 1 1 d . . . . . H26A H 0.2050 0.6567 0.3148 0.090 Uiso 1 1 calc R . . . . H26B H 0.2789 0.6552 0.2809 0.090 Uiso 1 1 calc R . . . . C27 C 0.1329(3) 0.6401(2) 0.24730(15) 0.0589(10) Uani 1 1 d . . . . . C28 C 0.0629(3) 0.6740(3) 0.21513(16) 0.0653(11) Uani 1 1 d . . . . . H28 H 0.0664 0.7187 0.2145 0.078 Uiso 1 1 calc R . . . . C29 C -0.0135(4) 0.6419(3) 0.18333(18) 0.0792(15) Uani 1 1 d . . . . . H29 H -0.0606 0.6655 0.1619 0.095 Uiso 1 1 calc R . . . . C30 C -0.0196(5) 0.5775(4) 0.1835(2) 0.0980(19) Uani 1 1 d . . . . . H30 H -0.0697 0.5561 0.1620 0.118 Uiso 1 1 calc R . . . . C31 C 0.0494(8) 0.5440(4) 0.2157(3) 0.153(4) Uani 1 1 d . . . . . H31 H 0.0464 0.4993 0.2163 0.184 Uiso 1 1 calc R . . . . C32 C 0.1235(6) 0.5757(3) 0.2476(3) 0.110(3) Uani 1 1 d . . . . . H32 H 0.1683 0.5518 0.2699 0.132 Uiso 1 1 calc R . . . . C33 C 0.4173(2) 0.75825(19) 0.42350(12) 0.0455(8) Uani 1 1 d . . . . . C34 C 0.4106(3) 0.81615(19) 0.44367(14) 0.0480(8) Uani 1 1 d . . . . . C35 C 0.4957(3) 0.8468(2) 0.47827(16) 0.0568(10) Uani 1 1 d . . . . . H35A H 0.4691 0.8717 0.5008 0.068 Uiso 0.703(8) 1 calc R . P A 1 H35B H 0.5328 0.8756 0.4622 0.068 Uiso 0.703(8) 1 calc R . P A 1 H35C H 0.4968 0.8925 0.4717 0.068 Uiso 0.297(8) 1 calc R . P A 2 H35D H 0.4835 0.8418 0.5095 0.068 Uiso 0.297(8) 1 calc R . P A 2 C36 C 0.5666(4) 0.7939(3) 0.5036(2) 0.0603(14) Uani 0.703(8) 1 d . . P A 1 H36A H 0.6266 0.8138 0.5225 0.072 Uiso 0.703(8) 1 calc R . P A 1 H36B H 0.5329 0.7708 0.5245 0.072 Uiso 0.703(8) 1 calc R . P A 1 C36A C 0.5948(10) 0.8191(8) 0.4773(5) 0.0603(14) Uani 0.297(8) 1 d . . P A 2 H36C H 0.6418 0.8303 0.5064 0.072 Uiso 0.297(8) 1 calc R . P A 2 H36D H 0.6190 0.8391 0.4520 0.072 Uiso 0.297(8) 1 calc R . P A 2 C37 C 0.5968(3) 0.7481(2) 0.47138(17) 0.0648(11) Uani 1 1 d . . . . . H37A H 0.6325 0.7128 0.4894 0.078 Uiso 0.703(8) 1 calc R . P A 1 H37B H 0.6437 0.7694 0.4557 0.078 Uiso 0.703(8) 1 calc R . P A 1 H37C H 0.5958 0.7280 0.5012 0.078 Uiso 0.297(8) 1 calc R . P A 2 H37D H 0.6599 0.7364 0.4633 0.078 Uiso 0.297(8) 1 calc R . P A 2 C38 C 0.5110(2) 0.72096(19) 0.43465(13) 0.0459(8) Uani 1 1 d . . . . . C39 C 0.6033(3) 0.6312(2) 0.42094(15) 0.0543(9) Uani 1 1 d . . . . . C40 C 0.6880(3) 0.6513(2) 0.40529(18) 0.0647(11) Uani 1 1 d . . . . . H40 H 0.6875 0.6909 0.3904 0.078 Uiso 1 1 calc R . . . . C41 C 0.7730(3) 0.6125(2) 0.41173(19) 0.0674(12) Uani 1 1 d . . . . . H41 H 0.8285 0.6261 0.4006 0.081 Uiso 1 1 calc R . . . . C42 C 0.7767(3) 0.5536(2) 0.43460(17) 0.0626(11) Uani 1 1 d . . . . . C43 C 0.6932(4) 0.5342(2) 0.44894(18) 0.0652(11) Uani 1 1 d . . . . . H43 H 0.6940 0.4944 0.4636 0.078 Uiso 1 1 calc R . . . . C44 C 0.6061(3) 0.5717(2) 0.44250(17) 0.0628(10) Uani 1 1 d . . . . . H44 H 0.5500 0.5568 0.4526 0.075 Uiso 1 1 calc R . . . . C45 C 0.8714(4) 0.5131(3) 0.4430(2) 0.0850(16) Uani 1 1 d . . . . . H45A H 0.8994 0.5141 0.4156 0.127 Uiso 1 1 calc GR . . . . H45B H 0.8552 0.4695 0.4493 0.127 Uiso 1 1 calc GR . . . . H45C H 0.9199 0.5299 0.4693 0.127 Uiso 1 1 calc GR . . . . Cl1 Cl 0.20434(12) 0.50672(7) 0.42801(6) 0.0917(5) Uani 1 1 d . . . . . Cl2 Cl 0.43871(13) 0.89581(10) 0.17151(6) 0.1064(6) Uani 1 1 d . . . . . N1 N 0.1793(2) 0.79045(18) 0.42646(12) 0.0541(8) Uani 1 1 d . . . . . N2 N 0.2166(3) 0.74060(19) 0.28452(13) 0.0652(9) Uani 1 1 d . . . . . N3 N 0.5136(2) 0.66830(17) 0.41288(13) 0.0554(8) Uani 1 1 d . . . . . O1 O 0.32815(19) 0.85427(13) 0.43418(11) 0.0553(7) Uani 1 1 d . . . . . C1' C 0.7417(3) 0.2261(2) 0.41564(13) 0.0494(9) Uani 1 1 d . . . . . C1A C 1.1279(5) 0.3045(4) 0.4818(3) 0.0604(15) Uani 0.532(8) 1 d . . P B 2 H1AA H 1.1886 0.3267 0.4979 0.072 Uiso 0.532(8) 1 calc R . P B 2 H1AB H 1.1015 0.2810 0.5051 0.072 Uiso 0.532(8) 1 calc R . P B 2 C2' C 0.6810(3) 0.1880(3) 0.43842(14) 0.0606(11) Uani 1 1 d . . . . . H2' H 0.6320 0.2078 0.4512 0.073 Uiso 1 1 calc R . . . . C3' C 0.6928(4) 0.1233(3) 0.44201(18) 0.0724(13) Uani 1 1 d . . . . . H3' H 0.6529 0.0989 0.4575 0.087 Uiso 1 1 calc R . . . . C4' C 0.7643(4) 0.0942(3) 0.4226(2) 0.0745(13) Uani 1 1 d . . . . . C5' C 0.8246(3) 0.1290(2) 0.39930(16) 0.0591(10) Uani 1 1 d . . . . . H5' H 0.8717 0.1082 0.3858 0.071 Uiso 1 1 calc R . . . . C6' C 0.8140(3) 0.19493(19) 0.39634(12) 0.0466(8) Uani 1 1 d . . . . . C7' C 0.8804(2) 0.23546(18) 0.37202(12) 0.0438(8) Uani 1 1 d . . . . . H7' H 0.9042 0.2092 0.3488 0.053 Uiso 1 1 calc R . . . . C8' C 0.8186(3) 0.29239(19) 0.34774(13) 0.0464(8) Uani 1 1 d . . . . . H8' H 0.8644 0.3196 0.3345 0.056 Uiso 1 1 calc R . . . . C9' C 0.7879(3) 0.33055(18) 0.38656(14) 0.0486(8) Uani 1 1 d . . . . . H9' H 0.7453 0.3665 0.3722 0.058 Uiso 1 1 calc R . . . . C10' C 0.6816(3) 0.3281(3) 0.44364(15) 0.0611(11) Uani 1 1 d . . . . . H10C H 0.7141 0.3698 0.4497 0.073 Uiso 1 1 calc R . . . . H10D H 0.6925 0.3053 0.4732 0.073 Uiso 1 1 calc R . . . . C11' C 0.5682(3) 0.3388(2) 0.42596(14) 0.0520(9) Uani 1 1 d . . . . . C12' C 0.5134(3) 0.3115(3) 0.38499(17) 0.0702(13) Uani 1 1 d . . . . . H12' H 0.5454 0.2855 0.3669 0.084 Uiso 1 1 calc R . . . . C13' C 0.4107(4) 0.3233(4) 0.37109(19) 0.0873(18) Uani 1 1 d . . . . . H13' H 0.3738 0.3043 0.3438 0.105 Uiso 1 1 calc R . . . . C14' C 0.3635(4) 0.3619(4) 0.3965(2) 0.100(2) Uani 1 1 d . . . . . H14' H 0.2949 0.3703 0.3864 0.120 Uiso 1 1 calc R . . . . C15' C 0.4171(4) 0.3886(4) 0.4373(2) 0.100(2) Uani 1 1 d . . . . . H15' H 0.3847 0.4152 0.4549 0.120 Uiso 1 1 calc R . . . . C16' C 0.5189(3) 0.3762(3) 0.45250(17) 0.0712(13) Uani 1 1 d . . . . . H16' H 0.5544 0.3932 0.4808 0.085 Uiso 1 1 calc R . . . . C17' C 0.8120(3) 0.2712(2) 0.24199(13) 0.0532(9) Uani 1 1 d . . . . . C18' C 0.8756(3) 0.2415(2) 0.21716(15) 0.0619(11) Uani 1 1 d . . . . . H18' H 0.8837 0.1971 0.2191 0.074 Uiso 1 1 calc R . . . . C19' C 0.9274(3) 0.2764(3) 0.18958(16) 0.0671(12) Uani 1 1 d . . . . . H19' H 0.9707 0.2557 0.1738 0.081 Uiso 1 1 calc R . . . . C20' C 0.9138(3) 0.3423(3) 0.18587(16) 0.0658(11) Uani 1 1 d . . . . . C21' C 0.8485(4) 0.3726(2) 0.20744(15) 0.0624(11) Uani 1 1 d . . . . . H21' H 0.8391 0.4168 0.2038 0.075 Uiso 1 1 calc R . . . . C22' C 0.7951(3) 0.3381(2) 0.23512(14) 0.0551(9) Uani 1 1 d . . . . . C23' C 0.7141(3) 0.3662(2) 0.25418(16) 0.0632(11) Uani 1 1 d . . . . . H23' H 0.6882 0.4062 0.2433 0.076 Uiso 1 1 calc R . . . . C24' C 0.6769(3) 0.3367(2) 0.28613(15) 0.0627(11) Uani 1 1 d . . . . . H24' H 0.6208 0.3529 0.2956 0.075 Uiso 1 1 calc R . . . . C25' C 0.7282(3) 0.2749(2) 0.30739(14) 0.0531(9) Uani 1 1 d . . . . . H25' H 0.6797 0.2491 0.3198 0.064 Uiso 1 1 calc R . . . . C26' C 0.7615(4) 0.1687(2) 0.27271(15) 0.0640(11) Uani 1 1 d . . . . . H26C H 0.7446 0.1557 0.3019 0.077 Uiso 1 1 calc R . . . . H26D H 0.8295 0.1538 0.2735 0.077 Uiso 1 1 calc R . . . . C27' C 0.6894(3) 0.1353(2) 0.23251(14) 0.0570(10) Uani 1 1 d . . . . . C28' C 0.6096(3) 0.1659(3) 0.20398(15) 0.0637(11) Uani 1 1 d . . . . . H28' H 0.6018 0.2101 0.2067 0.076 Uiso 1 1 calc R . . . . C29' C 0.5398(4) 0.1314(3) 0.17080(18) 0.0760(14) Uani 1 1 d . . . . . H29' H 0.4852 0.1527 0.1520 0.091 Uiso 1 1 calc R . . . . C30' C 0.5505(5) 0.0669(3) 0.1656(2) 0.0901(17) Uani 1 1 d . . . . . H30' H 0.5035 0.0441 0.1436 0.108 Uiso 1 1 calc R . . . . C31' C 0.6319(6) 0.0360(3) 0.1933(3) 0.108(2) Uani 1 1 d . . . . . H31' H 0.6404 -0.0080 0.1899 0.130 Uiso 1 1 calc R . . . . C32' C 0.7013(5) 0.0702(3) 0.2265(2) 0.0854(16) Uani 1 1 d . . . . . H32' H 0.7564 0.0489 0.2449 0.103 Uiso 1 1 calc R . . . . C33' C 0.9702(2) 0.26284(18) 0.40722(13) 0.0445(8) Uani 1 1 d . . . . . C34' C 0.9633(3) 0.32076(19) 0.42639(13) 0.0471(8) Uani 1 1 d . . . . . C35' C 1.0489(3) 0.3550(2) 0.45845(16) 0.0574(10) Uani 1 1 d . . . . . H35E H 1.0442 0.4007 0.4514 0.069 Uiso 0.468(8) 1 calc R . P B 1 H35F H 1.0425 0.3496 0.4905 0.069 Uiso 0.468(8) 1 calc R . P B 1 H35G H 1.0240 0.3785 0.4822 0.069 Uiso 0.532(8) 1 calc R . P B 2 H35H H 1.0796 0.3856 0.4408 0.069 Uiso 0.532(8) 1 calc R . P B 2 C36' C 1.1487(6) 0.3315(5) 0.4543(4) 0.0604(15) Uani 0.468(8) 1 d . . P B 1 H36E H 1.1986 0.3450 0.4817 0.072 Uiso 0.468(8) 1 calc R . P B 1 H36F H 1.1659 0.3513 0.4271 0.072 Uiso 0.468(8) 1 calc R . P B 1 C37' C 1.1543(3) 0.2595(2) 0.44972(19) 0.0678(12) Uani 1 1 d . . . . . H37E H 1.1622 0.2408 0.4807 0.081 Uiso 0.468(8) 1 calc R . P B 1 H37F H 1.2147 0.2493 0.4387 0.081 Uiso 0.468(8) 1 calc R . P B 1 H37G H 1.1970 0.2265 0.4674 0.081 Uiso 0.532(8) 1 calc R . P B 2 H37H H 1.1937 0.2817 0.4307 0.081 Uiso 0.532(8) 1 calc R . P B 2 C38' C 1.0654(2) 0.22712(19) 0.41750(13) 0.0461(8) Uani 1 1 d . . . . . C39' C 1.1577(3) 0.1347(2) 0.40687(15) 0.0556(9) Uani 1 1 d . . . . . C40' C 1.2353(4) 0.1504(2) 0.38543(18) 0.0685(12) Uani 1 1 d . . . . . H40' H 1.2310 0.1878 0.3676 0.082 Uiso 1 1 calc R . . . . C41' C 1.3195(4) 0.1111(3) 0.3903(2) 0.0740(13) Uani 1 1 d . . . . . H41' H 1.3707 0.1225 0.3754 0.089 Uiso 1 1 calc R . . . . C42' C 1.3293(4) 0.0556(2) 0.41653(19) 0.0691(12) Uani 1 1 d . . . . . C43' C 1.2517(4) 0.0406(2) 0.4377(2) 0.0750(13) Uani 1 1 d . . . . . H43' H 1.2566 0.0036 0.4560 0.090 Uiso 1 1 calc R . . . . C44' C 1.1662(4) 0.0790(2) 0.43273(17) 0.0660(11) Uani 1 1 d . . . . . H44' H 1.1144 0.0669 0.4470 0.079 Uiso 1 1 calc R . . . . C45' C 1.4205(5) 0.0131(3) 0.4213(3) 0.098(2) Uani 1 1 d . . . . . H45D H 1.4002 -0.0282 0.4079 0.147 Uiso 1 1 calc GR . . . . H45E H 1.4520 0.0081 0.4539 0.147 Uiso 1 1 calc GR . . . . H45F H 1.4675 0.0324 0.4053 0.147 Uiso 1 1 calc GR . . . . Cl1' Cl 0.77804(19) 0.01046(8) 0.42643(9) 0.1316(8) Uani 1 1 d . . . . . Cl2' Cl 0.97913(12) 0.38586(9) 0.15117(5) 0.0950(5) Uani 1 1 d . . . . . N1' N 0.7306(2) 0.29241(17) 0.41224(11) 0.0514(8) Uani 1 1 d . . . . . N2' N 0.7606(3) 0.23861(17) 0.27039(12) 0.0574(8) Uani 1 1 d . . . . . N3' N 1.0670(2) 0.17100(18) 0.39946(13) 0.0556(8) Uani 1 1 d . . . . . O1' O 0.87776(19) 0.35725(13) 0.41761(11) 0.0557(7) Uani 1 1 d . . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 C1 0.0337(15) 0.064(2) 0.0424(18) 0.0039(17) -0.0023(13) -0.0006(15) C2 0.0410(18) 0.078(3) 0.052(2) 0.007(2) 0.0042(16) -0.0003(18) C3 0.047(2) 0.086(3) 0.057(2) 0.022(2) 0.0030(17) -0.008(2) C4 0.058(2) 0.060(2) 0.061(2) 0.016(2) -0.0073(19) -0.0056(19) C5 0.0457(18) 0.058(2) 0.051(2) 0.0056(18) -0.0007(16) 0.0005(16) C6 0.0374(16) 0.059(2) 0.0415(17) 0.0043(16) -0.0023(13) -0.0012(15) C7 0.0346(15) 0.0519(19) 0.0472(19) 0.0017(16) 0.0025(14) 0.0007(14) C8 0.0393(17) 0.058(2) 0.052(2) 0.0110(18) 0.0031(15) 0.0017(15) C9 0.0384(17) 0.056(2) 0.058(2) 0.0049(18) -0.0022(16) 0.0055(15) C10 0.0442(19) 0.081(3) 0.058(2) -0.014(2) 0.0049(17) -0.0018(19) C11 0.0409(18) 0.058(2) 0.052(2) 0.0021(17) 0.0050(15) 0.0046(15) C12 0.048(2) 0.097(4) 0.058(2) -0.011(2) 0.0063(18) 0.009(2) C13 0.049(2) 0.118(4) 0.060(3) -0.005(3) -0.008(2) 0.004(3) C14 0.045(2) 0.100(4) 0.074(3) 0.016(3) 0.005(2) 0.016(2) C15 0.054(2) 0.093(4) 0.076(3) 0.007(3) 0.018(2) 0.020(2) C16 0.055(2) 0.075(3) 0.054(2) -0.003(2) 0.0069(18) 0.007(2) C17 0.060(2) 0.060(2) 0.0424(19) -0.0011(18) -0.0093(17) 0.0031(18) C18 0.081(3) 0.068(3) 0.053(2) -0.005(2) -0.003(2) 0.013(2) C19 0.070(3) 0.091(4) 0.053(2) -0.007(2) 0.004(2) 0.010(3) C20 0.064(3) 0.092(4) 0.048(2) 0.002(2) 0.0011(19) -0.007(2) C21 0.073(3) 0.061(2) 0.052(2) 0.003(2) -0.002(2) 0.002(2) C22 0.059(2) 0.064(2) 0.047(2) 0.0060(18) -0.0044(17) 0.0081(19) C23 0.076(3) 0.079(3) 0.060(3) 0.020(2) 0.004(2) 0.028(3) C24 0.054(2) 0.103(4) 0.061(3) 0.016(3) 0.000(2) 0.025(2) C25 0.049(2) 0.074(3) 0.051(2) 0.013(2) -0.0015(17) 0.0004(19) C26 0.084(3) 0.068(3) 0.059(3) 0.015(2) -0.016(2) -0.004(2) C27 0.059(2) 0.065(3) 0.049(2) -0.0005(19) 0.0043(18) -0.0018(19) C28 0.057(2) 0.077(3) 0.057(2) -0.006(2) 0.0031(19) 0.005(2) C29 0.052(2) 0.119(5) 0.061(3) -0.008(3) 0.000(2) 0.008(3) C30 0.091(4) 0.098(4) 0.093(4) -0.012(4) -0.003(3) -0.031(3) C31 0.189(9) 0.078(4) 0.145(7) -0.002(5) -0.064(6) -0.041(5) C32 0.131(6) 0.067(3) 0.102(5) 0.008(3) -0.040(4) -0.007(3) C33 0.0313(15) 0.058(2) 0.0450(18) 0.0008(16) 0.0034(13) 0.0003(14) C34 0.0356(16) 0.053(2) 0.054(2) 0.0049(17) 0.0064(15) 0.0017(15) C35 0.0433(18) 0.057(2) 0.066(2) -0.0048(19) 0.0031(17) -0.0028(16) C36 0.044(3) 0.075(4) 0.054(3) -0.007(3) -0.004(2) 0.004(2) C36A 0.044(3) 0.075(4) 0.054(3) -0.007(3) -0.004(2) 0.004(2) C37 0.0388(18) 0.068(3) 0.077(3) -0.007(2) -0.0102(18) 0.0081(18) C38 0.0356(16) 0.054(2) 0.0461(18) 0.0050(16) 0.0055(14) 0.0002(14) C39 0.0470(19) 0.059(2) 0.055(2) -0.0036(18) 0.0074(16) 0.0081(17) C40 0.059(2) 0.055(2) 0.083(3) 0.018(2) 0.022(2) 0.0137(19) C41 0.055(2) 0.064(3) 0.088(3) 0.006(2) 0.024(2) 0.0110(19) C42 0.060(2) 0.052(2) 0.073(3) -0.003(2) 0.008(2) 0.0120(18) C43 0.067(3) 0.052(2) 0.075(3) 0.010(2) 0.011(2) 0.0049(19) C44 0.057(2) 0.060(2) 0.072(3) 0.007(2) 0.016(2) 0.0016(19) C45 0.068(3) 0.061(3) 0.120(5) -0.003(3) 0.008(3) 0.022(2) Cl1 0.0928(9) 0.0617(7) 0.1148(11) 0.0223(7) 0.0108(8) -0.0043(6) Cl2 0.0960(10) 0.1346(15) 0.0923(10) 0.0169(10) 0.0289(8) -0.0199(10) N1 0.0376(14) 0.064(2) 0.0594(19) -0.0037(16) 0.0078(13) -0.0006(14) N2 0.073(2) 0.063(2) 0.0518(19) 0.0035(17) -0.0021(17) -0.0069(18) N3 0.0422(16) 0.060(2) 0.0605(19) -0.0033(16) 0.0039(14) 0.0091(14) O1 0.0399(13) 0.0493(14) 0.0726(18) -0.0030(13) 0.0041(12) 0.0029(11) C1' 0.0352(15) 0.067(2) 0.0410(17) -0.0032(17) -0.0016(13) -0.0024(15) C1A 0.041(3) 0.065(4) 0.067(4) -0.009(3) -0.006(3) -0.002(3) C2' 0.0431(19) 0.089(3) 0.048(2) 0.003(2) 0.0066(16) -0.0043(19) C3' 0.064(3) 0.088(3) 0.063(3) 0.016(3) 0.010(2) -0.014(2) C4' 0.077(3) 0.063(3) 0.081(3) 0.011(2) 0.012(3) -0.011(2) C5' 0.056(2) 0.056(2) 0.064(2) 0.0010(19) 0.0090(18) -0.0021(18) C6' 0.0407(16) 0.053(2) 0.0425(18) -0.0024(15) 0.0009(14) -0.0017(15) C7' 0.0349(15) 0.0500(19) 0.0444(18) -0.0033(15) 0.0048(13) 0.0022(14) C8' 0.0385(16) 0.053(2) 0.0461(19) 0.0011(16) 0.0056(14) 0.0040(14) C9' 0.0366(16) 0.0488(19) 0.056(2) -0.0026(17) 0.0014(15) 0.0059(14) C10' 0.0406(18) 0.083(3) 0.056(2) -0.022(2) 0.0035(16) 0.0029(18) C11' 0.0389(17) 0.068(2) 0.0473(19) -0.0004(18) 0.0049(15) 0.0057(16) C12' 0.049(2) 0.096(4) 0.061(2) -0.019(2) 0.0025(18) 0.010(2) C13' 0.051(2) 0.137(5) 0.065(3) -0.007(3) -0.006(2) 0.013(3) C14' 0.050(2) 0.171(7) 0.073(3) 0.002(4) 0.000(2) 0.038(3) C15' 0.068(3) 0.146(6) 0.089(4) -0.010(4) 0.024(3) 0.050(4) C16' 0.056(2) 0.096(4) 0.058(2) -0.009(2) 0.0054(19) 0.016(2) C17' 0.0510(19) 0.060(2) 0.0410(18) -0.0093(17) -0.0054(15) 0.0021(17) C18' 0.065(2) 0.065(3) 0.051(2) -0.012(2) 0.0044(19) 0.006(2) C19' 0.059(2) 0.086(3) 0.054(2) -0.012(2) 0.0067(19) 0.003(2) C20' 0.058(2) 0.081(3) 0.054(2) -0.010(2) 0.0041(19) -0.011(2) C21' 0.071(3) 0.064(3) 0.047(2) 0.0008(19) 0.0032(19) -0.003(2) C22' 0.053(2) 0.061(2) 0.047(2) -0.0003(18) 0.0007(16) 0.0031(18) C23' 0.060(2) 0.067(3) 0.058(2) 0.006(2) 0.0043(19) 0.018(2) C24' 0.048(2) 0.080(3) 0.055(2) 0.004(2) 0.0006(17) 0.020(2) C25' 0.0438(18) 0.063(2) 0.048(2) 0.0017(18) 0.0009(15) -0.0010(16) C26' 0.071(3) 0.060(2) 0.051(2) 0.0024(19) -0.0076(19) -0.005(2) C27' 0.057(2) 0.064(2) 0.048(2) -0.0017(19) 0.0069(17) -0.0100(19) C28' 0.057(2) 0.076(3) 0.054(2) -0.008(2) 0.0044(18) 0.002(2) C29' 0.054(2) 0.102(4) 0.065(3) -0.004(3) -0.002(2) -0.004(2) C30' 0.078(3) 0.096(4) 0.086(4) -0.012(3) -0.004(3) -0.032(3) C31' 0.122(5) 0.066(3) 0.115(5) -0.015(3) -0.018(4) -0.022(3) C32' 0.091(4) 0.061(3) 0.088(4) -0.006(3) -0.015(3) 0.000(3) C33' 0.0342(15) 0.052(2) 0.0461(18) -0.0046(15) 0.0054(14) 0.0009(14) C34' 0.0355(16) 0.054(2) 0.0504(19) -0.0052(16) 0.0064(14) 0.0009(14) C35' 0.0437(19) 0.059(2) 0.065(2) -0.012(2) 0.0033(17) -0.0035(17) C36' 0.041(3) 0.065(4) 0.067(4) -0.009(3) -0.006(3) -0.002(3) C37' 0.0378(18) 0.067(3) 0.088(3) -0.008(2) -0.0088(19) 0.0056(18) C38' 0.0358(16) 0.054(2) 0.0474(19) -0.0013(16) 0.0061(14) 0.0022(14) C39' 0.0469(19) 0.059(2) 0.060(2) -0.0024(19) 0.0097(17) 0.0098(17) C40' 0.063(3) 0.065(3) 0.081(3) 0.020(2) 0.024(2) 0.020(2) C41' 0.060(2) 0.076(3) 0.094(3) 0.012(3) 0.036(3) 0.016(2) C42' 0.061(2) 0.061(3) 0.086(3) 0.003(2) 0.018(2) 0.021(2) C43' 0.081(3) 0.061(3) 0.086(3) 0.018(2) 0.023(3) 0.017(2) C44' 0.064(2) 0.064(3) 0.074(3) 0.010(2) 0.023(2) 0.009(2) C45' 0.081(3) 0.073(3) 0.143(6) 0.012(4) 0.029(4) 0.035(3) Cl1' 0.1658(19) 0.0641(9) 0.179(2) 0.0325(11) 0.0690(17) -0.0029(10) Cl2' 0.0943(10) 0.1171(12) 0.0797(9) -0.0076(8) 0.0327(7) -0.0311(9) N1' 0.0380(14) 0.064(2) 0.0513(17) -0.0092(15) 0.0069(12) 0.0045(13) N2' 0.065(2) 0.0540(19) 0.0489(18) -0.0024(15) 0.0043(15) -0.0016(16) N3' 0.0423(16) 0.061(2) 0.0609(19) -0.0048(16) 0.0052(14) 0.0115(14) O1' 0.0387(12) 0.0517(15) 0.0722(18) -0.0163(13) 0.0027(12) 0.0050(11) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag C1 C2 1.407(6) . ? C1 C6 1.398(5) . ? C1 N1 1.398(6) . ? C2 C3 1.347(7) . ? C3 C4 1.388(7) . ? C4 C5 1.383(6) . ? C4 Cl1 1.742(5) . ? C5 C6 1.384(6) . ? C6 C7 1.515(5) . ? C7 C8 1.524(5) . ? C7 C33 1.516(5) . ? C8 C9 1.527(6) . ? C8 C25 1.541(5) . ? C9 N1 1.432(5) . ? C9 O1 1.469(4) . ? C10 C11 1.515(5) . ? C10 N1 1.458(5) . ? C11 C12 1.374(6) . ? C11 C16 1.374(6) . ? C12 C13 1.382(6) . ? C13 C14 1.358(7) . ? C14 C15 1.365(8) . ? C15 C16 1.399(6) . ? C17 C18 1.385(7) . ? C17 C22 1.418(6) . ? C17 N2 1.384(6) . ? C18 C19 1.397(8) . ? C19 C20 1.375(8) . ? C20 C21 1.359(7) . ? C20 Cl2 1.745(5) . ? C21 C22 1.394(7) . ? C22 C23 1.457(7) . ? C23 C24 1.320(7) . ? C24 C25 1.518(7) . ? C25 N2 1.475(6) . ? C26 C27 1.507(6) . ? C26 N2 1.448(6) . ? C27 C28 1.374(6) . ? C27 C32 1.344(8) . ? C28 C29 1.399(7) . ? C29 C30 1.341(9) . ? C30 C31 1.364(11) . ? C31 C32 1.377(9) . ? C33 C34 1.352(6) . ? C33 C38 1.462(5) . ? C34 C35 1.498(5) . ? C34 O1 1.349(4) . ? C35 C36 1.538(7) . ? C35 C36A 1.470(14) . ? C36 C37 1.462(8) . ? C36A C37 1.486(17) . ? C37 C38 1.508(5) . ? C38 N3 1.271(5) . ? C39 C40 1.394(6) . ? C39 C44 1.386(6) . ? C39 N3 1.416(5) . ? C40 C41 1.386(6) . ? C41 C42 1.391(7) . ? C42 C43 1.356(7) . ? C42 C45 1.510(6) . ? C43 C44 1.393(6) . ? C1' C2' 1.413(6) . ? C1' C6' 1.397(5) . ? C1' N1' 1.387(6) . ? C1A C35' 1.548(9) . ? C1A C37' 1.426(10) . ? C2' C3' 1.357(8) . ? C3' C4' 1.370(8) . ? C4' C5' 1.382(7) . ? C4' Cl1' 1.750(5) . ? C5' C6' 1.378(6) . ? C6' C7' 1.521(5) . ? C7' C8' 1.530(5) . ? C7' C33' 1.521(5) . ? C8' C9' 1.519(5) . ? C8' C25' 1.546(5) . ? C9' N1' 1.435(5) . ? C9' O1' 1.459(4) . ? C10' C11' 1.527(5) . ? C10' N1' 1.454(5) . ? C11' C12' 1.384(6) . ? C11' C16' 1.374(6) . ? C12' C13' 1.385(6) . ? C13' C14' 1.350(8) . ? C14' C15' 1.371(9) . ? C15' C16' 1.379(7) . ? C17' C18' 1.392(6) . ? C17' C22' 1.417(6) . ? C17' N2' 1.377(6) . ? C18' C19' 1.388(7) . ? C19' C20' 1.382(7) . ? C20' C21' 1.353(7) . ? C20' Cl2' 1.745(5) . ? C21' C22' 1.400(6) . ? C22' C23' 1.462(6) . ? C23' C24' 1.311(7) . ? C24' C25' 1.524(6) . ? C25' N2' 1.467(5) . ? C26' C27' 1.520(6) . ? C26' N2' 1.454(6) . ? C27' C28' 1.369(6) . ? C27' C32' 1.377(7) . ? C28' C29' 1.395(7) . ? C29' C30' 1.359(9) . ? C30' C31' 1.376(9) . ? C31' C32' 1.389(8) . ? C33' C34' 1.340(5) . ? C33' C38' 1.463(5) . ? C34' C35' 1.501(5) . ? C34' O1' 1.363(4) . ? C35' C36' 1.471(10) . ? C36' C37' 1.505(11) . ? C37' C38' 1.514(5) . ? C38' N3' 1.282(5) . ? C39' C40' 1.380(6) . ? C39' C44' 1.374(7) . ? C39' N3' 1.420(5) . ? C40' C41' 1.388(6) . ? C41' C42' 1.375(7) . ? C42' C43' 1.373(7) . ? C42' C45' 1.501(6) . ? C43' C44' 1.389(7) . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C6 C1 C2 118.7(4) . . ? C6 C1 N1 120.1(3) . . ? N1 C1 C2 121.2(4) . . ? C3 C2 C1 121.0(4) . . ? C2 C3 C4 120.1(4) . . ? C3 C4 Cl1 119.9(4) . . ? C5 C4 C3 120.4(4) . . ? C5 C4 Cl1 119.7(4) . . ? C4 C5 C6 119.8(4) . . ? C1 C6 C7 118.4(4) . . ? C5 C6 C1 119.9(4) . . ? C5 C6 C7 121.7(4) . . ? C6 C7 C8 109.0(3) . . ? C6 C7 C33 110.8(3) . . ? C33 C7 C8 108.0(3) . . ? C7 C8 C9 105.6(3) . . ? C7 C8 C25 115.3(4) . . ? C9 C8 C25 113.0(3) . . ? N1 C9 C8 112.1(3) . . ? N1 C9 O1 110.7(3) . . ? O1 C9 C8 109.4(3) . . ? N1 C10 C11 115.1(3) . . ? C12 C11 C10 123.6(4) . . ? C12 C11 C16 118.0(4) . . ? C16 C11 C10 118.3(4) . . ? C11 C12 C13 121.1(4) . . ? C14 C13 C12 121.0(5) . . ? C13 C14 C15 118.8(4) . . ? C14 C15 C16 120.7(4) . . ? C11 C16 C15 120.4(4) . . ? C18 C17 C22 118.2(4) . . ? N2 C17 C18 123.6(4) . . ? N2 C17 C22 118.1(4) . . ? C17 C18 C19 121.2(5) . . ? C20 C19 C18 119.0(5) . . ? C19 C20 Cl2 119.1(4) . . ? C21 C20 C19 121.4(5) . . ? C21 C20 Cl2 119.5(4) . . ? C20 C21 C22 120.4(5) . . ? C17 C22 C23 117.3(4) . . ? C21 C22 C17 119.5(4) . . ? C21 C22 C23 122.9(4) . . ? C24 C23 C22 121.5(4) . . ? C23 C24 C25 118.7(4) . . ? C24 C25 C8 110.6(4) . . ? N2 C25 C8 110.5(3) . . ? N2 C25 C24 107.9(4) . . ? N2 C26 C27 116.2(4) . . ? C28 C27 C26 123.9(4) . . ? C32 C27 C26 118.3(4) . . ? C32 C27 C28 117.6(5) . . ? C27 C28 C29 120.6(5) . . ? C30 C29 C28 120.7(5) . . ? C29 C30 C31 118.5(6) . . ? C30 C31 C32 120.7(7) . . ? C27 C32 C31 121.9(6) . . ? C34 C33 C7 119.7(3) . . ? C34 C33 C38 120.9(3) . . ? C38 C33 C7 119.3(3) . . ? C33 C34 C35 123.8(3) . . ? O1 C34 C33 124.5(3) . . ? O1 C34 C35 111.7(3) . . ? C34 C35 C36 109.2(4) . . ? C36A C35 C34 113.1(7) . . ? C37 C36 C35 112.8(5) . . ? C35 C36A C37 115.5(11) . . ? C36 C37 C38 114.9(4) . . ? C36A C37 C38 115.1(6) . . ? C33 C38 C37 117.1(3) . . ? N3 C38 C33 117.6(3) . . ? N3 C38 C37 125.2(3) . . ? C40 C39 N3 121.7(4) . . ? C44 C39 C40 118.4(4) . . ? C44 C39 N3 119.8(4) . . ? C41 C40 C39 120.3(4) . . ? C40 C41 C42 121.1(4) . . ? C41 C42 C45 120.4(5) . . ? C43 C42 C41 117.9(4) . . ? C43 C42 C45 121.7(5) . . ? C42 C43 C44 122.4(4) . . ? C39 C44 C43 119.8(4) . . ? C1 N1 C9 121.7(3) . . ? C1 N1 C10 120.5(4) . . ? C9 N1 C10 116.6(4) . . ? C17 N2 C25 118.8(4) . . ? C17 N2 C26 121.8(4) . . ? C26 N2 C25 118.3(4) . . ? C38 N3 C39 120.2(3) . . ? C34 O1 C9 117.1(3) . . ? C6' C1' C2' 117.9(4) . . ? N1' C1' C2' 121.6(4) . . ? N1' C1' C6' 120.4(4) . . ? C37' C1A C35' 113.9(6) . . ? C3' C2' C1' 121.4(4) . . ? C2' C3' C4' 119.2(4) . . ? C3' C4' C5' 121.8(5) . . ? C3' C4' Cl1' 119.1(4) . . ? C5' C4' Cl1' 119.1(4) . . ? C6' C5' C4' 119.1(4) . . ? C1' C6' C7' 118.4(3) . . ? C5' C6' C1' 120.5(4) . . ? C5' C6' C7' 121.0(3) . . ? C6' C7' C8' 109.0(3) . . ? C33' C7' C6' 111.0(3) . . ? C33' C7' C8' 107.4(3) . . ? C7' C8' C25' 115.7(3) . . ? C9' C8' C7' 105.6(3) . . ? C9' C8' C25' 113.0(3) . . ? N1' C9' C8' 112.1(3) . . ? N1' C9' O1' 111.0(3) . . ? O1' C9' C8' 109.5(3) . . ? N1' C10' C11' 115.4(3) . . ? C12' C11' C10' 122.8(4) . . ? C16' C11' C10' 118.1(4) . . ? C16' C11' C12' 119.1(4) . . ? C11' C12' C13' 119.6(5) . . ? C14' C13' C12' 120.9(5) . . ? C13' C14' C15' 119.8(4) . . ? C14' C15' C16' 120.3(5) . . ? C11' C16' C15' 120.3(5) . . ? C18' C17' C22' 117.4(4) . . ? N2' C17' C18' 123.7(4) . . ? N2' C17' C22' 118.7(4) . . ? C19' C18' C17' 121.8(5) . . ? C20' C19' C18' 119.1(4) . . ? C19' C20' Cl2' 118.9(4) . . ? C21' C20' C19' 121.0(5) . . ? C21' C20' Cl2' 120.1(4) . . ? C20' C21' C22' 120.6(5) . . ? C17' C22' C23' 116.7(4) . . ? C21' C22' C17' 119.8(4) . . ? C21' C22' C23' 123.3(4) . . ? C24' C23' C22' 121.8(4) . . ? C23' C24' C25' 118.2(4) . . ? C24' C25' C8' 109.1(3) . . ? N2' C25' C8' 111.6(3) . . ? N2' C25' C24' 108.4(3) . . ? N2' C26' C27' 115.0(4) . . ? C28' C27' C26' 123.1(4) . . ? C28' C27' C32' 118.5(4) . . ? C32' C27' C26' 118.2(4) . . ? C27' C28' C29' 120.6(5) . . ? C30' C29' C28' 120.8(5) . . ? C29' C30' C31' 119.1(5) . . ? C30' C31' C32' 120.3(6) . . ? C27' C32' C31' 120.7(5) . . ? C34' C33' C7' 120.0(3) . . ? C34' C33' C38' 120.7(3) . . ? C38' C33' C7' 119.2(3) . . ? C33' C34' C35' 124.9(3) . . ? C33' C34' O1' 123.8(3) . . ? O1' C34' C35' 111.3(3) . . ? C34' C35' C1A 108.5(4) . . ? C36' C35' C34' 112.9(5) . . ? C35' C36' C37' 113.8(7) . . ? C1A C37' C38' 114.8(4) . . ? C36' C37' C38' 116.6(4) . . ? C33' C38' C37' 116.6(3) . . ? N3' C38' C33' 118.1(3) . . ? N3' C38' C37' 125.3(3) . . ? C40' C39' N3' 121.9(4) . . ? C44' C39' C40' 118.2(4) . . ? C44' C39' N3' 119.7(4) . . ? C39' C40' C41' 120.6(4) . . ? C42' C41' C40' 121.7(4) . . ? C41' C42' C45' 121.3(5) . . ? C43' C42' C41' 117.1(4) . . ? C43' C42' C45' 121.6(5) . . ? C42' C43' C44' 122.0(5) . . ? C39' C44' C43' 120.4(4) . . ? C1' N1' C9' 121.5(3) . . ? C1' N1' C10' 121.3(4) . . ? C9' N1' C10' 115.4(3) . . ? C17' N2' C25' 118.0(3) . . ? C17' N2' C26' 121.3(4) . . ? C26' N2' C25' 118.7(4) . . ? C38' N3' C39' 120.9(3) . . ? C34' O1' C9' 117.7(3) . . ? _iucr_refine_instructions_details ; 201809362.res created by SHELXL-2014/7 TITL CF solution in P21/n CELL 1.54184 13.580532 20.775304 29.292081 90 102.8973 90 ZERR 8 0.000113 0.000212 0.00028 0 0.0009 0 LATT 1 SYMM 0.5-X,0.5+Y,0.5-Z SFAC C H Cl N O UNIT 360 312 16 24 8 EADP C36 C36A EADP C36' C1A L.S. 4 0 0 PLAN 20 MPLA C1 C2 C3 C4 C5 C6 MPLA C11 C12 C13 C14 C15 C16 MPLA C17 C18 C19 C20 C21 C22 MPLA C27 C28 C29 C30 C31 C32 MPLA C39 C40 C41 C42 C43 C44 fmap 2 acta REM REM REM WGHT 0.200000 FVAR 1.11832 0.70314 0.46756 C1 1 0.188234 0.723448 0.428665 11.00000 0.03375 0.06449 = 0.04242 0.00391 -0.00234 -0.00062 C2 1 0.125600 0.685906 0.450400 11.00000 0.04101 0.07837 = 0.05209 0.00694 0.00419 -0.00031 AFIX 43 H2 2 0.078762 0.706065 0.464409 11.00000 -1.20000 AFIX 0 C3 1 0.132409 0.621232 0.451239 11.00000 0.04743 0.08646 = 0.05696 0.02201 0.00298 -0.00838 AFIX 43 H3 2 0.091071 0.597133 0.466115 11.00000 -1.20000 AFIX 0 C4 1 0.201081 0.590494 0.429918 11.00000 0.05774 0.05991 = 0.06146 0.01552 -0.00734 -0.00560 C5 1 0.265534 0.625958 0.409226 11.00000 0.04571 0.05759 = 0.05061 0.00563 -0.00067 0.00046 AFIX 43 H5 2 0.312656 0.605174 0.395740 11.00000 -1.20000 AFIX 0 C6 1 0.259677 0.692452 0.408656 11.00000 0.03742 0.05867 = 0.04152 0.00428 -0.00225 -0.00123 C7 1 0.328892 0.733372 0.386596 11.00000 0.03461 0.05188 = 0.04717 0.00173 0.00245 0.00072 AFIX 13 H7 2 0.353902 0.707877 0.363404 11.00000 -1.20000 AFIX 0 C8 1 0.269967 0.791227 0.362759 11.00000 0.03931 0.05784 = 0.05246 0.01100 0.00310 0.00166 AFIX 13 H8 2 0.317166 0.818273 0.350428 11.00000 -1.20000 AFIX 0 C9 1 0.238016 0.828869 0.401819 11.00000 0.03843 0.05586 = 0.05798 0.00489 -0.00221 0.00552 AFIX 13 H9 2 0.196539 0.865386 0.387670 11.00000 -1.20000 AFIX 0 C10 1 0.125316 0.824672 0.456840 11.00000 0.04425 0.08128 = 0.05833 -0.01389 0.00491 -0.00179 AFIX 23 H10A 2 0.150642 0.868444 0.460807 11.00000 -1.20000 H10B 2 0.140669 0.804313 0.487410 11.00000 -1.20000 AFIX 0 C11 1 0.011605 0.827057 0.439476 11.00000 0.04091 0.05846 = 0.05245 0.00212 0.00499 0.00458 C12 1 -0.038589 0.802437 0.397119 11.00000 0.04768 0.09708 = 0.05761 -0.01098 0.00627 0.00929 AFIX 43 H12 2 -0.001957 0.783065 0.377560 11.00000 -1.20000 AFIX 0 C13 1 -0.142563 0.805975 0.383095 11.00000 0.04862 0.11753 = 0.06048 -0.00482 -0.00788 0.00447 AFIX 43 H13 2 -0.174803 0.788979 0.354256 11.00000 -1.20000 AFIX 0 C14 1 -0.198364 0.833896 0.410788 11.00000 0.04473 0.09998 = 0.07366 0.01556 0.00486 0.01623 AFIX 43 H14 2 -0.268225 0.836810 0.400924 11.00000 -1.20000 AFIX 0 C15 1 -0.150079 0.857621 0.453383 11.00000 0.05363 0.09332 = 0.07588 0.00679 0.01846 0.02044 AFIX 43 H15 2 -0.187569 0.875869 0.473029 11.00000 -1.20000 AFIX 0 C16 1 -0.044765 0.854753 0.467768 11.00000 0.05473 0.07476 = 0.05393 -0.00272 0.00693 0.00748 AFIX 43 H16 2 -0.012733 0.871700 0.496656 11.00000 -1.20000 AFIX 0 C17 1 0.267809 0.774684 0.256463 11.00000 0.05987 0.05972 = 0.04239 -0.00110 -0.00925 0.00310 C18 1 0.333521 0.746597 0.232332 11.00000 0.08114 0.06773 = 0.05312 -0.00549 -0.00308 0.01291 AFIX 43 H18 2 0.342621 0.702213 0.233689 11.00000 -1.20000 AFIX 0 C19 1 0.386409 0.783686 0.205984 11.00000 0.07029 0.09104 = 0.05293 -0.00659 0.00367 0.00952 AFIX 43 H19 2 0.431342 0.764417 0.190413 11.00000 -1.20000 AFIX 0 C20 1 0.370963 0.849125 0.203444 11.00000 0.06407 0.09226 = 0.04841 0.00155 0.00110 -0.00666 C21 1 0.302202 0.877801 0.224160 11.00000 0.07326 0.06111 = 0.05224 0.00310 -0.00222 0.00214 AFIX 43 H21 2 0.290448 0.921801 0.220503 11.00000 -1.20000 AFIX 0 C22 1 0.249180 0.841687 0.250855 11.00000 0.05939 0.06367 = 0.04653 0.00595 -0.00442 0.00809 C23 1 0.166799 0.868088 0.269503 11.00000 0.07623 0.07888 = 0.06016 0.01955 0.00389 0.02811 AFIX 43 H23 2 0.140513 0.908229 0.259275 11.00000 -1.20000 AFIX 0 C24 1 0.128629 0.836367 0.300563 11.00000 0.05367 0.10265 = 0.06110 0.01617 0.00014 0.02515 AFIX 43 H24 2 0.070919 0.851197 0.309327 11.00000 -1.20000 AFIX 0 C25 1 0.180759 0.775200 0.321706 11.00000 0.04930 0.07372 = 0.05137 0.01304 -0.00151 0.00040 AFIX 13 H25 2 0.132153 0.748171 0.333087 11.00000 -1.20000 AFIX 0 C26 1 0.213797 0.670937 0.284476 11.00000 0.08433 0.06766 = 0.05911 0.01470 -0.01580 -0.00393 AFIX 23 H26A 2 0.204956 0.656681 0.314840 11.00000 -1.20000 H26B 2 0.278876 0.655175 0.280885 11.00000 -1.20000 AFIX 0 C27 1 0.132881 0.640058 0.247302 11.00000 0.05860 0.06534 = 0.04905 -0.00048 0.00433 -0.00185 C28 1 0.062937 0.673992 0.215127 11.00000 0.05749 0.07662 = 0.05725 -0.00575 0.00311 0.00472 AFIX 43 H28 2 0.066415 0.718679 0.214476 11.00000 -1.20000 AFIX 0 C29 1 -0.013477 0.641884 0.183334 11.00000 0.05173 0.11920 = 0.06084 -0.00840 -0.00014 0.00799 AFIX 43 H29 2 -0.060559 0.665485 0.161876 11.00000 -1.20000 AFIX 0 C30 1 -0.019586 0.577460 0.183457 11.00000 0.09120 0.09805 = 0.09333 -0.01197 -0.00339 -0.03122 AFIX 43 H30 2 -0.069745 0.556088 0.162006 11.00000 -1.20000 AFIX 0 C31 1 0.049406 0.543972 0.215744 11.00000 0.18868 0.07833 = 0.14510 -0.00203 -0.06366 -0.04071 AFIX 43 H31 2 0.046375 0.499265 0.216265 11.00000 -1.20000 AFIX 0 C32 1 0.123488 0.575658 0.247574 11.00000 0.13089 0.06695 = 0.10208 0.00786 -0.03985 -0.00738 AFIX 43 H32 2 0.168288 0.551831 0.269888 11.00000 -1.20000 AFIX 0 C33 1 0.417341 0.758252 0.423496 11.00000 0.03129 0.05774 = 0.04497 0.00076 0.00339 0.00028 C34 1 0.410623 0.816155 0.443665 11.00000 0.03561 0.05322 = 0.05360 0.00488 0.00637 0.00166 C35 1 0.495690 0.846771 0.478271 11.00000 0.04330 0.05694 = 0.06593 -0.00476 0.00315 -0.00284 PART 1 AFIX 23 H35A 2 0.469120 0.871654 0.500838 21.00000 -1.20000 H35B 2 0.532753 0.875648 0.462193 21.00000 -1.20000 AFIX 23 PART 0 PART 2 H35C 2 0.496760 0.892492 0.471688 -21.00000 -1.20000 H35D 2 0.483547 0.841792 0.509480 -21.00000 -1.20000 AFIX 0 PART 0 PART 1 C36 1 0.566599 0.793889 0.503635 21.00000 0.04426 0.07544 = 0.05402 -0.00706 -0.00438 0.00439 AFIX 23 H36A 2 0.626590 0.813841 0.522543 21.00000 -1.20000 H36B 2 0.532892 0.770758 0.524548 21.00000 -1.20000 AFIX 0 PART 0 PART 2 C36A 1 0.594823 0.819113 0.477349 -21.00000 0.04426 0.07544 = 0.05402 -0.00706 -0.00438 0.00439 AFIX 23 H36C 2 0.641758 0.830310 0.506364 -21.00000 -1.20000 H36D 2 0.619032 0.839053 0.451981 -21.00000 -1.20000 AFIX 0 PART 0 C37 1 0.596771 0.748145 0.471378 11.00000 0.03880 0.06824 = 0.07655 -0.00739 -0.01018 0.00814 PART 1 AFIX 23 H37A 2 0.632470 0.712766 0.489448 21.00000 -1.20000 H37B 2 0.643701 0.769383 0.455744 21.00000 -1.20000 AFIX 23 PART 0 PART 2 H37C 2 0.595823 0.728044 0.501166 -21.00000 -1.20000 H37D 2 0.659941 0.736448 0.463329 -21.00000 -1.20000 AFIX 0 PART 0 C38 1 0.510975 0.720962 0.434652 11.00000 0.03560 0.05416 = 0.04614 0.00500 0.00553 0.00019 C39 1 0.603317 0.631225 0.420944 11.00000 0.04697 0.05865 = 0.05540 -0.00364 0.00744 0.00809 C40 1 0.688003 0.651280 0.405287 11.00000 0.05940 0.05501 = 0.08251 0.01835 0.02178 0.01370 AFIX 43 H40 2 0.687467 0.690889 0.390441 11.00000 -1.20000 AFIX 0 C41 1 0.772999 0.612497 0.411729 11.00000 0.05456 0.06363 = 0.08773 0.00561 0.02403 0.01102 AFIX 43 H41 2 0.828504 0.626096 0.400568 11.00000 -1.20000 AFIX 0 C42 1 0.776733 0.553584 0.434599 11.00000 0.05970 0.05154 = 0.07337 -0.00308 0.00787 0.01199 C43 1 0.693166 0.534174 0.448944 11.00000 0.06654 0.05192 = 0.07466 0.00970 0.01052 0.00493 AFIX 43 H43 2 0.694020 0.494409 0.463607 11.00000 -1.20000 AFIX 0 C44 1 0.606109 0.571675 0.442497 11.00000 0.05693 0.06039 = 0.07213 0.00682 0.01639 0.00158 AFIX 43 H44 2 0.550025 0.556782 0.452632 11.00000 -1.20000 AFIX 0 C45 1 0.871435 0.513081 0.442974 11.00000 0.06827 0.06071 = 0.12004 -0.00349 0.00841 0.02153 AFIX 137 H45A 2 0.899405 0.514100 0.415640 11.00000 -1.50000 H45B 2 0.855236 0.469492 0.449342 11.00000 -1.50000 H45C 2 0.919854 0.529911 0.469264 11.00000 -1.50000 AFIX 0 CL1 3 0.204344 0.506718 0.428005 11.00000 0.09284 0.06172 = 0.11484 0.02235 0.01084 -0.00435 CL2 3 0.438708 0.895812 0.171512 11.00000 0.09595 0.13457 = 0.09231 0.01689 0.02891 -0.01985 N1 4 0.179272 0.790454 0.426457 11.00000 0.03758 0.06387 = 0.05940 -0.00374 0.00784 -0.00061 N2 4 0.216608 0.740600 0.284519 11.00000 0.07335 0.06282 = 0.05184 0.00350 -0.00213 -0.00691 N3 4 0.513557 0.668297 0.412880 11.00000 0.04222 0.05973 = 0.06054 -0.00326 0.00390 0.00909 O1 5 0.328153 0.854275 0.434175 11.00000 0.03992 0.04931 = 0.07256 -0.00302 0.00406 0.00289 C1' 1 0.741709 0.226116 0.415638 11.00000 0.03519 0.06728 = 0.04102 -0.00324 -0.00160 -0.00238 PART 2 C1A 1 1.127940 0.304453 0.481785 -31.00000 0.04095 0.06528 = 0.06653 -0.00921 -0.00582 -0.00240 AFIX 23 H1AA 2 1.188591 0.326656 0.497926 -31.00000 -1.20000 H1AB 2 1.101463 0.281038 0.505076 -31.00000 -1.20000 AFIX 0 PART 0 C2' 1 0.681028 0.188045 0.438419 11.00000 0.04310 0.08890 = 0.04807 0.00276 0.00659 -0.00428 AFIX 43 H2' 2 0.631952 0.207802 0.451223 11.00000 -1.20000 AFIX 0 C3' 1 0.692841 0.123269 0.442011 11.00000 0.06416 0.08793 = 0.06331 0.01602 0.01012 -0.01432 AFIX 43 H3' 2 0.652914 0.098902 0.457469 11.00000 -1.20000 AFIX 0 C4' 1 0.764303 0.094182 0.422592 11.00000 0.07735 0.06309 = 0.08058 0.01069 0.01210 -0.01065 C5' 1 0.824598 0.128993 0.399297 11.00000 0.05559 0.05554 = 0.06418 0.00105 0.00903 -0.00211 AFIX 43 H5' 2 0.871685 0.108206 0.385790 11.00000 -1.20000 AFIX 0 C6' 1 0.814036 0.194935 0.396343 11.00000 0.04074 0.05276 = 0.04247 -0.00242 0.00093 -0.00170 C7' 1 0.880360 0.235456 0.372021 11.00000 0.03492 0.04998 = 0.04444 -0.00329 0.00475 0.00222 AFIX 13 H7' 2 0.904184 0.209248 0.348837 11.00000 -1.20000 AFIX 0 C8' 1 0.818643 0.292394 0.347738 11.00000 0.03850 0.05268 = 0.04609 0.00114 0.00561 0.00404 AFIX 13 H8' 2 0.864358 0.319555 0.334542 11.00000 -1.20000 AFIX 0 C9' 1 0.787899 0.330549 0.386559 11.00000 0.03662 0.04877 = 0.05632 -0.00255 0.00141 0.00591 AFIX 13 H9' 2 0.745341 0.366482 0.372159 11.00000 -1.20000 AFIX 0 C10' 1 0.681566 0.328113 0.443638 11.00000 0.04062 0.08332 = 0.05587 -0.02224 0.00354 0.00292 AFIX 23 H10C 2 0.714080 0.369787 0.449657 11.00000 -1.20000 H10D 2 0.692542 0.305326 0.473248 11.00000 -1.20000 AFIX 0 C11' 1 0.568212 0.338752 0.425957 11.00000 0.03885 0.06770 = 0.04734 -0.00040 0.00491 0.00568 C12' 1 0.513442 0.311527 0.384985 11.00000 0.04899 0.09644 = 0.06064 -0.01930 0.00247 0.01024 AFIX 43 H12' 2 0.545432 0.285498 0.366890 11.00000 -1.20000 AFIX 0 C13' 1 0.410735 0.323265 0.371087 11.00000 0.05099 0.13681 = 0.06548 -0.00674 -0.00556 0.01332 AFIX 43 H13' 2 0.373765 0.304308 0.343849 11.00000 -1.20000 AFIX 0 C14' 1 0.363528 0.361853 0.396534 11.00000 0.04957 0.17104 = 0.07321 0.00164 -0.00049 0.03834 AFIX 43 H14' 2 0.294855 0.370273 0.386402 11.00000 -1.20000 AFIX 0 C15' 1 0.417107 0.388582 0.437344 11.00000 0.06774 0.14579 = 0.08890 -0.01049 0.02391 0.05002 AFIX 43 H15' 2 0.384672 0.415203 0.454883 11.00000 -1.20000 AFIX 0 C16' 1 0.518917 0.376155 0.452495 11.00000 0.05599 0.09610 = 0.05806 -0.00947 0.00537 0.01550 AFIX 43 H16' 2 0.554360 0.393150 0.480783 11.00000 -1.20000 AFIX 0 C17' 1 0.811970 0.271206 0.241992 11.00000 0.05104 0.06018 = 0.04104 -0.00927 -0.00543 0.00210 C18' 1 0.875628 0.241516 0.217159 11.00000 0.06532 0.06521 = 0.05124 -0.01191 0.00439 0.00582 AFIX 43 H18' 2 0.883679 0.197074 0.219110 11.00000 -1.20000 AFIX 0 C19' 1 0.927408 0.276375 0.189576 11.00000 0.05913 0.08572 = 0.05378 -0.01249 0.00673 0.00296 AFIX 43 H19' 2 0.970695 0.255696 0.173801 11.00000 -1.20000 AFIX 0 C20' 1 0.913761 0.342260 0.185868 11.00000 0.05825 0.08112 = 0.05396 -0.01028 0.00410 -0.01122 C21' 1 0.848539 0.372641 0.207437 11.00000 0.07092 0.06411 = 0.04744 0.00083 0.00324 -0.00259 AFIX 43 H21' 2 0.839130 0.416847 0.203834 11.00000 -1.20000 AFIX 0 C22' 1 0.795089 0.338150 0.235124 11.00000 0.05329 0.06056 = 0.04660 -0.00027 0.00067 0.00307 C23' 1 0.714099 0.366248 0.254183 11.00000 0.06032 0.06694 = 0.05815 0.00581 0.00431 0.01773 AFIX 43 H23' 2 0.688194 0.406237 0.243345 11.00000 -1.20000 AFIX 0 C24' 1 0.676944 0.336655 0.286132 11.00000 0.04755 0.08032 = 0.05502 0.00405 0.00056 0.02042 AFIX 43 H24' 2 0.620833 0.352896 0.295567 11.00000 -1.20000 AFIX 0 C25' 1 0.728166 0.274934 0.307392 11.00000 0.04384 0.06346 = 0.04756 0.00165 0.00089 -0.00098 AFIX 13 H25' 2 0.679718 0.249094 0.319816 11.00000 -1.20000 AFIX 0 C26' 1 0.761453 0.168673 0.272708 11.00000 0.07116 0.05981 = 0.05094 0.00238 -0.00761 -0.00480 AFIX 23 H26C 2 0.744619 0.155696 0.301853 11.00000 -1.20000 H26D 2 0.829502 0.153779 0.273488 11.00000 -1.20000 AFIX 0 C27' 1 0.689424 0.135290 0.232507 11.00000 0.05691 0.06381 = 0.04804 -0.00167 0.00691 -0.00996 C28' 1 0.609564 0.165905 0.203979 11.00000 0.05698 0.07642 = 0.05385 -0.00782 0.00435 0.00166 AFIX 43 H28' 2 0.601779 0.210109 0.206740 11.00000 -1.20000 AFIX 0 C29' 1 0.539759 0.131370 0.170803 11.00000 0.05420 0.10159 = 0.06476 -0.00438 -0.00246 -0.00401 AFIX 43 H29' 2 0.485242 0.152695 0.152038 11.00000 -1.20000 AFIX 0 C30' 1 0.550508 0.066946 0.165596 11.00000 0.07802 0.09595 = 0.08572 -0.01171 -0.00416 -0.03188 AFIX 43 H30' 2 0.503538 0.044070 0.143584 11.00000 -1.20000 AFIX 0 C31' 1 0.631851 0.036028 0.193342 11.00000 0.12173 0.06646 = 0.11538 -0.01465 -0.01815 -0.02156 AFIX 43 H31' 2 0.640392 -0.007976 0.189860 11.00000 -1.20000 AFIX 0 C32' 1 0.701298 0.070216 0.226537 11.00000 0.09076 0.06084 = 0.08804 -0.00604 -0.01548 -0.00029 AFIX 43 H32' 2 0.756374 0.048941 0.244918 11.00000 -1.20000 AFIX 0 C33' 1 0.970181 0.262836 0.407219 11.00000 0.03415 0.05156 = 0.04608 -0.00456 0.00544 0.00090 C34' 1 0.963329 0.320764 0.426394 11.00000 0.03555 0.05373 = 0.05044 -0.00517 0.00644 0.00094 C35' 1 1.048932 0.355040 0.458448 11.00000 0.04367 0.05892 = 0.06539 -0.01181 0.00335 -0.00347 PART 1 AFIX 23 H35E 2 1.044247 0.400698 0.451372 31.00000 -1.20000 H35F 2 1.042451 0.349586 0.490534 31.00000 -1.20000 AFIX 23 PART 0 PART 2 H35G 2 1.024050 0.378461 0.482220 -31.00000 -1.20000 H35H 2 1.079634 0.385589 0.440777 -31.00000 -1.20000 AFIX 0 PART 0 PART 1 C36' 1 1.148682 0.331475 0.454302 31.00000 0.04095 0.06528 = 0.06653 -0.00921 -0.00582 -0.00240 AFIX 23 H36E 2 1.198643 0.345018 0.481710 31.00000 -1.20000 H36F 2 1.165936 0.351287 0.427134 31.00000 -1.20000 AFIX 0 PART 0 C37' 1 1.154288 0.259508 0.449717 11.00000 0.03781 0.06668 = 0.08809 -0.00755 -0.00880 0.00557 PART 1 AFIX 23 H37E 2 1.162160 0.240831 0.480673 31.00000 -1.20000 H37F 2 1.214732 0.249256 0.438723 31.00000 -1.20000 AFIX 23 PART 0 PART 2 H37G 2 1.197043 0.226542 0.467429 -31.00000 -1.20000 H37H 2 1.193668 0.281693 0.430721 -31.00000 -1.20000 AFIX 0 PART 0 C38' 1 1.065438 0.227122 0.417496 11.00000 0.03580 0.05361 = 0.04744 -0.00128 0.00614 0.00218 C39' 1 1.157736 0.134687 0.406872 11.00000 0.04692 0.05854 = 0.06033 -0.00238 0.00972 0.00985 C40' 1 1.235259 0.150431 0.385432 11.00000 0.06322 0.06533 = 0.08102 0.02045 0.02446 0.01998 AFIX 43 H40' 2 1.230987 0.187763 0.367577 11.00000 -1.20000 AFIX 0 C41' 1 1.319510 0.111078 0.390269 11.00000 0.06021 0.07635 = 0.09430 0.01155 0.03634 0.01646 AFIX 43 H41' 2 1.370668 0.122495 0.375366 11.00000 -1.20000 AFIX 0 C42' 1 1.329301 0.055633 0.416530 11.00000 0.06110 0.06071 = 0.08610 0.00251 0.01762 0.02128 C43' 1 1.251734 0.040602 0.437718 11.00000 0.08073 0.06064 = 0.08569 0.01838 0.02296 0.01663 AFIX 43 H43' 2 1.256581 0.003610 0.455965 11.00000 -1.20000 AFIX 0 C44' 1 1.166209 0.078970 0.432732 11.00000 0.06406 0.06410 = 0.07361 0.01033 0.02338 0.00874 AFIX 43 H44' 2 1.114354 0.066865 0.446990 11.00000 -1.20000 AFIX 0 C45' 1 1.420460 0.013148 0.421334 11.00000 0.08076 0.07261 = 0.14298 0.01218 0.02930 0.03503 AFIX 137 H45D 2 1.400213 -0.028226 0.407868 11.00000 -1.50000 H45E 2 1.452000 0.008081 0.453889 11.00000 -1.50000 H45F 2 1.467461 0.032421 0.405315 11.00000 -1.50000 AFIX 0 CL1' 3 0.778037 0.010457 0.426433 11.00000 0.16578 0.06405 = 0.17925 0.03252 0.06895 -0.00288 CL2' 3 0.979133 0.385859 0.151171 11.00000 0.09430 0.11709 = 0.07975 -0.00755 0.03273 -0.03115 N1' 4 0.730622 0.292412 0.412239 11.00000 0.03802 0.06355 = 0.05129 -0.00916 0.00694 0.00454 N2' 4 0.760565 0.238608 0.270386 11.00000 0.06527 0.05401 = 0.04885 -0.00240 0.00428 -0.00160 N3' 4 1.066951 0.170998 0.399460 11.00000 0.04233 0.06071 = 0.06092 -0.00479 0.00521 0.01152 O1' 5 0.877760 0.357252 0.417608 11.00000 0.03873 0.05167 = 0.07220 -0.01631 0.00272 0.00499 HKLF 4 REM CF solution in P21/n REM R1 = 0.1225 for 10018 Fo > 4sig(Fo) and 0.1448 for all 14381 data REM 929 parameters refined using 0 restraints END WGHT 0.2000 0.0000 REM Highest difference peak 3.290, deepest hole -0.339, 1-sigma level 0.170 Q1 1 0.4514 0.5261 0.3330 11.00000 0.05 3.29 Q2 1 1.0029 0.0213 0.3182 11.00000 0.05 2.68 Q3 1 0.9820 0.0140 0.2609 11.00000 0.05 1.99 Q4 1 0.5370 0.5039 0.3256 11.00000 0.05 1.63 Q5 1 -0.0283 1.0188 0.1818 11.00000 0.05 1.61 Q6 1 0.4685 0.5949 0.2575 11.00000 0.05 1.58 Q7 1 0.1338 1.0106 0.2040 11.00000 0.05 0.97 Q8 1 0.2569 0.4986 0.4190 11.00000 0.05 0.61 Q9 1 0.7984 0.0041 0.4011 11.00000 0.05 0.59 Q10 1 1.4330 0.0183 0.4328 11.00000 0.05 0.52 Q11 1 0.3952 0.9250 0.1777 11.00000 0.05 0.43 Q12 1 0.9432 0.5415 0.4391 11.00000 0.05 0.39 Q13 1 0.0241 0.5389 0.2171 11.00000 0.05 0.37 Q14 1 0.6589 0.3224 0.4437 11.00000 0.05 0.35 Q15 1 -0.1754 0.8557 0.4135 11.00000 0.05 0.34 Q16 1 1.1057 0.1608 0.4074 11.00000 0.05 0.34 Q17 1 0.7184 0.2961 0.3002 11.00000 0.05 0.33 Q18 1 0.4371 0.8679 0.1765 11.00000 0.05 0.32 Q19 1 1.0437 0.2159 0.4221 11.00000 0.05 0.31 Q20 1 0.8458 0.2136 0.3845 11.00000 0.05 0.30 REM The information below was added by Olex2. REM REM R1 = 0.1225 for 10018 Fo > 4sig(Fo) and 0.1448 for all 38541 data REM n/a parameters refined using n/a restraints REM Highest difference peak 3.29, deepest hole -0.34 REM Mean Shift 0.01, Max Shift -0.546. REM +++ Tabular Listing of Refinement Information +++ REM R1_all = 0.1448 REM R1_gt = 0.1225 REM wR_ref = 0.3780 REM GOOF = 1.431 REM Shift_max = -0.546 REM Shift_mean = 0.01 REM Reflections_all = 38541 REM Reflections_gt = 10018 REM Parameters = n/a REM Hole = -0.34 REM Peak = 3.29 REM Flack = n/a ; _olex2_submission_special_instructions 'No special instructions were received'