# Electronic Supplementary Material (ESI) for Chemical Science. # This journal is © The Royal Society of Chemistry 2020 ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_mcg1662 _database_code_depnum_ccdc_archive 'CCDC 1876028' loop_ _audit_author_name _audit_author_address 'Dale Swenson' ;UIOWA United States of America ; _audit_update_record ; 2018-10-29 deposited with the CCDC. 2020-03-09 downloaded from the CCDC. ; _audit_creation_date 2018-10-22 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_absolute_configuration unk _chemical_name_systematic ? _chemical_formula_moiety 'C8 H8 O5, C12 H10 N2' _chemical_formula_sum 'C20 H18 N2 O5' _chemical_formula_weight 366.36 _chemical_melting_point ? loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system triclinic _space_group_IT_number 2 _space_group_name_H-M_alt 'P -1' _space_group_name_Hall '-P 1' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, -y, -z' _cell_length_a 8.2700(8) _cell_length_b 9.1848(9) _cell_length_c 12.4194(12) _cell_angle_alpha 71.619(5) _cell_angle_beta 82.065(5) _cell_angle_gamma 79.191(5) _cell_volume 876.19(15) _cell_formula_units_Z 2 _cell_measurement_reflns_used 2905 _cell_measurement_temperature 298(2) _cell_measurement_theta_max 25.35 _cell_measurement_theta_min 1 _shelx_estimated_absorpt_T_max 0.984 _shelx_estimated_absorpt_T_min 0.974 _exptl_absorpt_coefficient_mu 0.101 _exptl_absorpt_correction_T_max 0.9934 _exptl_absorpt_correction_T_min 0.9373 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details 'HKL Scalepack (Otwinowski & Minor, 1997)' _exptl_absorpt_special_details ? _exptl_crystal_colour colourless _exptl_crystal_colour_lustre . _exptl_crystal_colour_modifier . _exptl_crystal_colour_primary colourless _exptl_crystal_density_diffrn 1.389 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description prism _exptl_crystal_F_000 384 _exptl_crystal_preparation ? _exptl_crystal_recrystallization_method ? _exptl_crystal_size_max 0.26 _exptl_crystal_size_mid 0.23 _exptl_crystal_size_min 0.16 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0166 _diffrn_reflns_av_unetI/netI 0.0295 _diffrn_reflns_Laue_measured_fraction_full 0.988 _diffrn_reflns_Laue_measured_fraction_max 0.986 _diffrn_reflns_limit_h_max 9 _diffrn_reflns_limit_h_min -9 _diffrn_reflns_limit_k_max 11 _diffrn_reflns_limit_k_min -10 _diffrn_reflns_limit_l_max 14 _diffrn_reflns_limit_l_min -14 _diffrn_reflns_number 5206 _diffrn_reflns_point_group_measured_fraction_full 0.988 _diffrn_reflns_point_group_measured_fraction_max 0.986 _diffrn_reflns_theta_full 25.242 _diffrn_reflns_theta_max 25.315 _diffrn_reflns_theta_min 1.734 _diffrn_ambient_temperature 298.15 _diffrn_detector_area_resol_mean ? _diffrn_measured_fraction_theta_full 0.988 _diffrn_measured_fraction_theta_max 0.986 _diffrn_measurement_device_type 'Nonius KappaCCD' _diffrn_measurement_method ? _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_source ? _reflns_Friedel_coverage 0.000 _reflns_Friedel_fraction_full . _reflns_Friedel_fraction_max . _reflns_number_gt 2399 _reflns_number_total 3148 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ? _computing_data_collection ? _computing_data_reduction ? _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution 'olex2.solve (Bourhis et al., 2015)' _refine_diff_density_max 0.434 _refine_diff_density_min -0.258 _refine_diff_density_rms 0.039 _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.053 _refine_ls_hydrogen_treatment mixed _refine_ls_matrix_type full _refine_ls_number_parameters 252 _refine_ls_number_reflns 3148 _refine_ls_number_restraints 2 _refine_ls_R_factor_all 0.0791 _refine_ls_R_factor_gt 0.0604 _refine_ls_restrained_S_all 1.054 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0805P)^2^+0.3884P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1568 _refine_ls_wR_factor_ref 0.1734 _refine_special_details 'All nonhydrogen atoms were identified from the difference Fourier map within several refinement steps. Hydrogen atoms associated with carbon atoms were refined in geometrically constrained positions with isotropic thermal parameter. some reflections were omitted due to beamstop shadowing.' _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups 2. Restrained distances H003-O003 0.85 with sigma of 0.02 O002-H002 0.85 with sigma of 0.02 3.a Ternary CH refined with riding coordinates: C006(H006), C009(H009), C00A(H00A), C00N(H00N) 3.b Aromatic/amide H refined with riding coordinates: C00E(H00E), C00G(H00G), C00H(H00H), C00I(H00I), C00J(H00J), C00K(H00K), C00L(H00L), C00M(H00M), C00O(H00O), C00P(H00P), C00Q(H00Q), C00R(H00R) ; _atom_sites_solution_hydrogens mixed _atom_sites_solution_primary iterative _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group O001 O -0.3637(2) 0.77172(19) 0.77588(13) 0.0604(5) Uani 1 1 d . . . . . O002 O -0.1242(3) 0.3158(2) 0.92726(17) 0.0834(7) Uani 1 1 d D . . . . O003 O 0.1358(2) 0.5395(3) 0.80488(16) 0.0867(7) Uani 1 1 d D . . . . N004 N 0.3052(3) 0.3973(2) 0.66020(17) 0.0630(6) Uani 1 1 d . . . . . N005 N 1.0069(3) -0.1338(2) 0.20205(19) 0.0656(6) Uani 1 1 d . . . . . C006 C -0.2509(3) 0.5672(2) 0.92118(17) 0.0494(5) Uani 1 1 d . . . . . H006 H -0.2445 0.5361 1.0037 0.059 Uiso 1 1 calc R . . . . O007 O -0.3254(3) 0.4151(3) 0.8161(2) 0.1046(8) Uani 1 1 d . . . . . O008 O -0.0345(3) 0.6434(4) 0.67450(17) 0.1125(9) Uani 1 1 d . . . . . C009 C -0.1170(3) 0.6739(2) 0.85929(17) 0.0476(5) Uani 1 1 d . . . . . H009 H -0.0528 0.6873 0.9153 0.057 Uiso 1 1 calc R . . . . C00A C -0.4113(3) 0.6828(3) 0.8890(2) 0.0590(6) Uani 1 1 d . . . . . H00A H -0.5104 0.6350 0.8968 0.071 Uiso 1 1 calc R . . . . C00B C 0.4990(3) 0.2525(3) 0.51094(19) 0.0511(5) Uani 1 1 d . . . . . C00C C 0.8189(3) 0.0023(3) 0.36060(19) 0.0517(5) Uani 1 1 d . . . . . C00D C -0.2380(3) 0.4258(3) 0.88257(19) 0.0558(6) Uani 1 1 d . . . . . C00E C 1.0316(3) -0.1906(3) 0.3099(2) 0.0662(7) Uani 1 1 d . . . . . H00E H 1.1132 -0.2762 0.3323 0.079 Uiso 1 1 calc R . . . . C00F C -0.0024(3) 0.6179(3) 0.7694(2) 0.0552(6) Uani 1 1 d . . . . . C00G C 0.8013(3) 0.0582(3) 0.2449(2) 0.0653(7) Uani 1 1 d . . . . . H00G H 0.7237 0.1453 0.2173 0.078 Uiso 1 1 calc R . . . . C00H C 0.8947(4) -0.0111(3) 0.1710(2) 0.0706(7) Uani 1 1 d . . . . . H00H H 0.8783 0.0307 0.0940 0.085 Uiso 1 1 calc R . . . . C00I C 0.5226(3) 0.2095(3) 0.6242(2) 0.0684(7) Uani 1 1 d . . . . . H00I H 0.6060 0.1287 0.6533 0.082 Uiso 1 1 calc R . . . . C00J C 0.4265(4) 0.2826(3) 0.6943(2) 0.0722(7) Uani 1 1 d . . . . . H00J H 0.4470 0.2504 0.7707 0.087 Uiso 1 1 calc R . . . . C00K C 0.2760(3) 0.4394(3) 0.5508(2) 0.0686(7) Uani 1 1 d . . . . . H00K H 0.1890 0.5182 0.5253 0.082 Uiso 1 1 calc R . . . . C00L C -0.4252(3) 0.8000(3) 0.9533(2) 0.0698(7) Uani 1 1 d . . . . . H00L H -0.4975 0.8073 1.0164 0.084 Uiso 1 1 calc R . . . . C00M C 0.9406(3) -0.1282(3) 0.3939(2) 0.0665(7) Uani 1 1 d . . . . . H00M H 0.9607 -0.1727 0.4701 0.080 Uiso 1 1 calc R . . . . C00N C -0.2311(3) 0.8277(3) 0.8058(2) 0.0569(6) Uani 1 1 d . . . . . H00N H -0.1778 0.9028 0.7429 0.068 Uiso 1 1 calc R . . . . C00O C 0.3712(3) 0.3700(3) 0.4730(2) 0.0607(6) Uani 1 1 d . . . . . H00O H 0.3485 0.4026 0.3971 0.073 Uiso 1 1 calc R . . . . C00P C -0.3140(3) 0.8891(3) 0.9018(2) 0.0694(7) Uani 1 1 d . . . . . H00P H -0.2911 0.9731 0.9205 0.083 Uiso 1 1 calc R . . . . C00Q C 0.6030(3) 0.1846(3) 0.4258(2) 0.0620(6) Uani 1 1 d . . . . . H00Q H 0.5815 0.2316 0.3501 0.074 Uiso 1 1 calc R . . . . C00R C 0.7202(3) 0.0671(3) 0.4459(2) 0.0642(7) Uani 1 1 d . . . . . H00R H 0.7434 0.0200 0.5213 0.077 Uiso 1 1 calc R . . . . H002 H -0.110(5) 0.250(4) 0.889(3) 0.123(13) Uiso 1 1 d D . . . . H003 H 0.192(5) 0.494(4) 0.755(3) 0.134(14) Uiso 1 1 d D . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 O001 0.0577(9) 0.0653(10) 0.0534(10) -0.0136(8) -0.0198(7) 0.0062(8) O002 0.1146(16) 0.0651(12) 0.0720(12) -0.0328(10) -0.0366(11) 0.0250(11) O003 0.0744(12) 0.1148(16) 0.0579(11) -0.0358(11) -0.0129(9) 0.0404(11) N004 0.0656(13) 0.0711(13) 0.0572(12) -0.0309(10) 0.0069(10) -0.0105(11) N005 0.0764(14) 0.0571(12) 0.0637(13) -0.0218(10) -0.0021(11) -0.0073(11) C006 0.0553(12) 0.0527(12) 0.0366(11) -0.0122(9) -0.0062(9) 0.0004(10) O007 0.131(2) 0.0830(14) 0.1197(19) -0.0500(13) -0.0622(16) 0.0069(13) O008 0.0814(14) 0.197(3) 0.0571(12) -0.0620(14) -0.0162(10) 0.0345(15) C009 0.0477(11) 0.0545(12) 0.0416(11) -0.0186(9) -0.0094(9) 0.0014(9) C00A 0.0474(12) 0.0686(15) 0.0573(14) -0.0174(11) -0.0057(10) -0.0010(11) C00B 0.0471(12) 0.0563(13) 0.0555(13) -0.0244(10) -0.0062(10) -0.0068(10) C00C 0.0497(12) 0.0570(13) 0.0535(13) -0.0230(10) -0.0054(10) -0.0081(10) C00D 0.0652(14) 0.0587(14) 0.0417(12) -0.0137(10) -0.0025(10) -0.0085(12) C00E 0.0673(15) 0.0490(13) 0.0780(18) -0.0194(12) -0.0141(13) 0.0085(11) C00F 0.0532(13) 0.0594(13) 0.0517(14) -0.0178(11) -0.0015(10) -0.0051(11) C00G 0.0675(15) 0.0699(16) 0.0562(15) -0.0229(12) -0.0138(12) 0.0088(12) C00H 0.0829(18) 0.0718(17) 0.0559(15) -0.0242(13) -0.0067(13) 0.0004(14) C00I 0.0682(16) 0.0744(16) 0.0594(15) -0.0210(13) -0.0186(12) 0.0081(13) C00J 0.0767(17) 0.0878(19) 0.0510(14) -0.0242(13) -0.0137(12) 0.0020(15) C00K 0.0588(15) 0.0627(15) 0.0753(18) -0.0156(13) -0.0095(13) 0.0069(12) C00L 0.0603(15) 0.0782(17) 0.0667(16) -0.0313(14) -0.0028(12) 0.0152(14) C00M 0.0761(17) 0.0634(15) 0.0559(14) -0.0089(12) -0.0149(12) -0.0091(13) C00N 0.0596(14) 0.0510(13) 0.0560(14) -0.0129(10) -0.0100(11) 0.0002(10) C00O 0.0580(14) 0.0729(16) 0.0479(13) -0.0177(11) -0.0073(10) -0.0005(12) C00P 0.0673(16) 0.0614(15) 0.0816(18) -0.0336(14) -0.0148(14) 0.0128(13) C00Q 0.0600(14) 0.0699(15) 0.0600(15) -0.0247(12) -0.0095(11) -0.0074(12) C00R 0.0641(15) 0.0748(17) 0.0583(15) -0.0298(13) -0.0049(12) -0.0049(13) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag O001 C00A 1.428(3) . ? O001 C00N 1.432(3) . ? O002 C00D 1.284(3) . ? O002 H002 0.859(19) . ? O003 C00F 1.284(3) . ? O003 H003 0.886(19) . ? N004 C00J 1.318(3) . ? N004 C00K 1.333(3) . ? N005 C00E 1.305(3) . ? N005 C00H 1.308(3) . ? C006 H006 0.9800 . ? C006 C009 1.573(3) . ? C006 C00A 1.548(3) . ? C006 C00D 1.501(3) . ? O007 C00D 1.206(3) . ? O008 C00F 1.185(3) . ? C009 H009 0.9800 . ? C009 C00F 1.515(3) . ? C009 C00N 1.552(3) . ? C00A H00A 0.9800 . ? C00A C00L 1.510(4) . ? C00B C00I 1.367(3) . ? C00B C00O 1.376(3) . ? C00B C00Q 1.486(3) . ? C00C C00G 1.384(3) . ? C00C C00M 1.404(3) . ? C00C C00R 1.456(3) . ? C00E H00E 0.9300 . ? C00E C00M 1.408(4) . ? C00G H00G 0.9300 . ? C00G C00H 1.354(4) . ? C00H H00H 0.9300 . ? C00I H00I 0.9300 . ? C00I C00J 1.349(4) . ? C00J H00J 0.9300 . ? C00K H00K 0.9300 . ? C00K C00O 1.396(4) . ? C00L H00L 0.9300 . ? C00L C00P 1.309(4) . ? C00M H00M 0.9300 . ? C00N H00N 0.9800 . ? C00N C00P 1.504(4) . ? C00O H00O 0.9300 . ? C00P H00P 0.9300 . ? C00Q H00Q 0.9300 . ? C00Q C00R 1.292(4) . ? C00R H00R 0.9300 . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C00A O001 C00N 95.91(17) . . ? C00D O002 H002 107(3) . . ? C00F O003 H003 112(3) . . ? C00J N004 C00K 117.2(2) . . ? C00E N005 C00H 118.1(2) . . ? C009 C006 H006 109.8 . . ? C00A C006 H006 109.8 . . ? C00A C006 C009 100.53(17) . . ? C00D C006 H006 109.8 . . ? C00D C006 C009 113.83(18) . . ? C00D C006 C00A 112.8(2) . . ? C006 C009 H009 110.2 . . ? C00F C009 C006 114.25(18) . . ? C00F C009 H009 110.2 . . ? C00F C009 C00N 111.69(18) . . ? C00N C009 C006 99.91(17) . . ? C00N C009 H009 110.2 . . ? O001 C00A C006 101.60(17) . . ? O001 C00A H00A 115.1 . . ? O001 C00A C00L 101.6(2) . . ? C006 C00A H00A 115.1 . . ? C00L C00A C006 106.8(2) . . ? C00L C00A H00A 115.1 . . ? C00I C00B C00O 117.1(2) . . ? C00I C00B C00Q 125.0(2) . . ? C00O C00B C00Q 117.9(2) . . ? C00G C00C C00M 115.1(2) . . ? C00G C00C C00R 124.8(2) . . ? C00M C00C C00R 120.1(2) . . ? O002 C00D C006 113.5(2) . . ? O007 C00D O002 122.7(2) . . ? O007 C00D C006 123.8(2) . . ? N005 C00E H00E 118.5 . . ? N005 C00E C00M 123.0(2) . . ? C00M C00E H00E 118.5 . . ? O003 C00F C009 113.9(2) . . ? O008 C00F O003 122.0(2) . . ? O008 C00F C009 124.1(2) . . ? C00C C00G H00G 119.3 . . ? C00H C00G C00C 121.4(2) . . ? C00H C00G H00G 119.3 . . ? N005 C00H C00G 123.5(2) . . ? N005 C00H H00H 118.2 . . ? C00G C00H H00H 118.2 . . ? C00B C00I H00I 119.5 . . ? C00J C00I C00B 120.9(2) . . ? C00J C00I H00I 119.5 . . ? N004 C00J C00I 123.4(2) . . ? N004 C00J H00J 118.3 . . ? C00I C00J H00J 118.3 . . ? N004 C00K H00K 118.7 . . ? N004 C00K C00O 122.6(2) . . ? C00O C00K H00K 118.7 . . ? C00A C00L H00L 127.2 . . ? C00P C00L C00A 105.6(2) . . ? C00P C00L H00L 127.2 . . ? C00C C00M C00E 118.8(2) . . ? C00C C00M H00M 120.6 . . ? C00E C00M H00M 120.6 . . ? O001 C00N C009 101.61(17) . . ? O001 C00N H00N 114.9 . . ? O001 C00N C00P 101.7(2) . . ? C009 C00N H00N 114.9 . . ? C00P C00N C009 107.25(19) . . ? C00P C00N H00N 114.9 . . ? C00B C00O C00K 118.7(2) . . ? C00B C00O H00O 120.6 . . ? C00K C00O H00O 120.6 . . ? C00L C00P C00N 105.7(2) . . ? C00L C00P H00P 127.1 . . ? C00N C00P H00P 127.1 . . ? C00B C00Q H00Q 116.5 . . ? C00R C00Q C00B 126.9(2) . . ? C00R C00Q H00Q 116.5 . . ? C00C C00R H00R 117.2 . . ? C00Q C00R C00C 125.6(2) . . ? C00Q C00R H00R 117.2 . . ? loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_site_symmetry_A C006 H006 O003 0.98 2.50 3.447(3) 162.2 2_567 C009 H009 O002 0.98 2.59 3.564(3) 172.6 2_567 C00M H00M O008 0.93 2.57 3.466(3) 162.4 1_645 O002 H002 N005 0.859(19) 1.82(2) 2.640(3) 159(4) 2_656 O003 H003 N004 0.886(19) 1.759(19) 2.644(3) 178(4) . loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag O001 C00A C00L C00P -32.3(3) . . . . ? O001 C00N C00P C00L 32.4(3) . . . . ? N004 C00K C00O C00B 0.6(4) . . . . ? N005 C00E C00M C00C -0.9(4) . . . . ? C006 C009 C00F O003 -96.9(2) . . . . ? C006 C009 C00F O008 83.4(3) . . . . ? C006 C009 C00N O001 -36.38(19) . . . . ? C006 C009 C00N C00P 69.9(2) . . . . ? C006 C00A C00L C00P 73.8(3) . . . . ? C009 C006 C00A O001 35.9(2) . . . . ? C009 C006 C00A C00L -70.1(2) . . . . ? C009 C006 C00D O002 79.3(2) . . . . ? C009 C006 C00D O007 -100.8(3) . . . . ? C009 C00N C00P C00L -73.9(3) . . . . ? C00A O001 C00N C009 60.28(19) . . . . ? C00A O001 C00N C00P -50.3(2) . . . . ? C00A C006 C009 C00F -119.04(19) . . . . ? C00A C006 C009 C00N 0.31(19) . . . . ? C00A C006 C00D O002 -167.0(2) . . . . ? C00A C006 C00D O007 12.9(3) . . . . ? C00A C00L C00P C00N -0.1(3) . . . . ? C00B C00I C00J N004 0.4(5) . . . . ? C00B C00Q C00R C00C 179.4(2) . . . . ? C00C C00G C00H N005 -0.1(5) . . . . ? C00D C006 C009 C00F 1.8(3) . . . . ? C00D C006 C009 C00N 121.13(19) . . . . ? C00D C006 C00A O001 -85.6(2) . . . . ? C00D C006 C00A C00L 168.3(2) . . . . ? C00E N005 C00H C00G -1.2(4) . . . . ? C00F C009 C00N O001 84.8(2) . . . . ? C00F C009 C00N C00P -168.9(2) . . . . ? C00G C00C C00M C00E -0.3(4) . . . . ? C00G C00C C00R C00Q 0.2(4) . . . . ? C00H N005 C00E C00M 1.6(4) . . . . ? C00I C00B C00O C00K 1.1(4) . . . . ? C00I C00B C00Q C00R 6.8(4) . . . . ? C00J N004 C00K C00O -1.8(4) . . . . ? C00K N004 C00J C00I 1.3(4) . . . . ? C00M C00C C00G C00H 0.8(4) . . . . ? C00M C00C C00R C00Q -178.6(3) . . . . ? C00N O001 C00A C006 -60.0(2) . . . . ? C00N O001 C00A C00L 50.1(2) . . . . ? C00N C009 C00F O003 150.6(2) . . . . ? C00N C009 C00F O008 -29.0(4) . . . . ? C00O C00B C00I C00J -1.6(4) . . . . ? C00O C00B C00Q C00R -174.7(3) . . . . ? C00Q C00B C00I C00J 176.9(3) . . . . ? C00Q C00B C00O C00K -177.5(2) . . . . ? C00R C00C C00G C00H -178.0(3) . . . . ? C00R C00C C00M C00E 178.6(2) . . . . ? _shelx_res_file ; mcg1662.res created by SHELXL-2014/7 TITL mcg1662_a.res in P-1 REM Old TITL mcg1662 in P-1 #2 REM SHELXT solution in P-1 REM R1 0.227, Rweak 0.009, Alpha 0.068, Orientation as input REM Formula found by SHELXT: C21 N2 O4 CELL 0.71073 8.27 9.1848 12.4194 71.619 82.065 79.191 ZERR 2 0.0008 0.0009 0.0012 0.005 0.005 0.005 LATT 1 SFAC C H N O UNIT 40 36 4 10 EQIV $1 -X,1-Y,2-Z EQIV $2 1+X,-1+Y,+Z EQIV $3 1-X,-Y,1-Z DFIX 0.85 H003 O003 DFIX 0.85 O002 H002 L.S. 4 PLAN -20 SIZE 0.16 0.23 0.26 TEMP 25 HTAB C006 O003_$1 HTAB C009 O002_$1 HTAB C00M O008_$2 HTAB O002 N005_$3 HTAB O003 N004 BOND $H LIST 6 MORE -1 CONF fmap 2 acta OMIT 0 1 1 OMIT 0 1 0 OMIT -1 1 0 REM REM REM WGHT 0.080500 0.388400 FVAR 1.84476 O001 4 -0.363704 0.771720 0.775884 11.00000 0.05771 0.06526 = 0.05344 -0.01363 -0.01978 0.00624 O002 4 -0.124174 0.315839 0.927265 11.00000 0.11460 0.06510 = 0.07197 -0.03281 -0.03655 0.02498 O003 4 0.135812 0.539458 0.804875 11.00000 0.07438 0.11484 = 0.05791 -0.03582 -0.01285 0.04042 N004 3 0.305154 0.397332 0.660201 11.00000 0.06556 0.07113 = 0.05718 -0.03094 0.00689 -0.01046 N005 3 1.006905 -0.133846 0.202046 11.00000 0.07641 0.05711 = 0.06366 -0.02178 -0.00206 -0.00728 C006 1 -0.250934 0.567205 0.921175 11.00000 0.05525 0.05273 = 0.03663 -0.01216 -0.00619 0.00043 AFIX 13 H006 2 -0.244536 0.536063 1.003740 11.00000 -1.20000 AFIX 0 O007 4 -0.325435 0.415109 0.816131 11.00000 0.13112 0.08301 = 0.11969 -0.04996 -0.06220 0.00689 O008 4 -0.034549 0.643442 0.674502 11.00000 0.08142 0.19667 = 0.05709 -0.06203 -0.01621 0.03446 C009 1 -0.116991 0.673913 0.859295 11.00000 0.04769 0.05454 = 0.04158 -0.01855 -0.00941 0.00143 AFIX 13 H009 2 -0.052825 0.687317 0.915272 11.00000 -1.20000 AFIX 0 C00A 1 -0.411292 0.682826 0.888957 11.00000 0.04736 0.06860 = 0.05726 -0.01739 -0.00574 -0.00096 AFIX 13 H00A 2 -0.510383 0.634954 0.896816 11.00000 -1.20000 AFIX 0 C00B 1 0.499003 0.252484 0.510944 11.00000 0.04705 0.05627 = 0.05550 -0.02444 -0.00621 -0.00676 C00C 1 0.818947 0.002299 0.360599 11.00000 0.04966 0.05697 = 0.05349 -0.02298 -0.00543 -0.00812 C00D 1 -0.238043 0.425812 0.882571 11.00000 0.06519 0.05866 = 0.04174 -0.01375 -0.00245 -0.00848 C00E 1 1.031627 -0.190586 0.309900 11.00000 0.06735 0.04898 = 0.07795 -0.01942 -0.01412 0.00849 AFIX 43 H00E 2 1.113154 -0.276164 0.332297 11.00000 -1.20000 AFIX 0 C00F 1 -0.002412 0.617891 0.769434 11.00000 0.05322 0.05944 = 0.05166 -0.01777 -0.00153 -0.00510 C00G 1 0.801309 0.058240 0.244857 11.00000 0.06750 0.06987 = 0.05620 -0.02285 -0.01382 0.00883 AFIX 43 H00G 2 0.723654 0.145323 0.217253 11.00000 -1.20000 AFIX 0 C00H 1 0.894731 -0.011142 0.170952 11.00000 0.08293 0.07177 = 0.05592 -0.02423 -0.00672 0.00042 AFIX 43 H00H 2 0.878279 0.030666 0.093966 11.00000 -1.20000 AFIX 0 C00I 1 0.522561 0.209504 0.624177 11.00000 0.06823 0.07437 = 0.05944 -0.02099 -0.01860 0.00811 AFIX 43 H00I 2 0.605995 0.128715 0.653258 11.00000 -1.20000 AFIX 0 C00J 1 0.426493 0.282624 0.694322 11.00000 0.07669 0.08779 = 0.05105 -0.02416 -0.01373 0.00204 AFIX 43 H00J 2 0.446953 0.250414 0.770719 11.00000 -1.20000 AFIX 0 C00K 1 0.276046 0.439434 0.550844 11.00000 0.05878 0.06274 = 0.07534 -0.01556 -0.00947 0.00690 AFIX 43 H00K 2 0.188965 0.518150 0.525349 11.00000 -1.20000 AFIX 0 C00L 1 -0.425161 0.800000 0.953322 11.00000 0.06033 0.07815 = 0.06668 -0.03133 -0.00280 0.01516 AFIX 43 H00L 2 -0.497513 0.807298 1.016402 11.00000 -1.20000 AFIX 0 C00M 1 0.940583 -0.128230 0.393902 11.00000 0.07613 0.06340 = 0.05590 -0.00888 -0.01490 -0.00907 AFIX 43 H00M 2 0.960675 -0.172741 0.470132 11.00000 -1.20000 AFIX 0 C00N 1 -0.231124 0.827695 0.805841 11.00000 0.05962 0.05099 = 0.05599 -0.01291 -0.00997 0.00022 AFIX 13 H00N 2 -0.177750 0.902771 0.742894 11.00000 -1.20000 AFIX 0 C00O 1 0.371170 0.369993 0.473042 11.00000 0.05803 0.07289 = 0.04791 -0.01768 -0.00732 -0.00048 AFIX 43 H00O 2 0.348548 0.402553 0.397050 11.00000 -1.20000 AFIX 0 C00P 1 -0.314035 0.889149 0.901752 11.00000 0.06734 0.06136 = 0.08159 -0.03365 -0.01481 0.01282 AFIX 43 H00P 2 -0.291133 0.973071 0.920544 11.00000 -1.20000 AFIX 0 C00Q 1 0.603008 0.184575 0.425845 11.00000 0.06004 0.06994 = 0.06004 -0.02469 -0.00948 -0.00736 AFIX 43 H00Q 2 0.581452 0.231625 0.350080 11.00000 -1.20000 AFIX 0 C00R 1 0.720180 0.067139 0.445915 11.00000 0.06410 0.07485 = 0.05831 -0.02979 -0.00488 -0.00492 AFIX 43 H00R 2 0.743449 0.019951 0.521345 11.00000 -1.20000 AFIX 0 H002 2 -0.109725 0.250239 0.889201 11.00000 0.12304 H003 2 0.191890 0.494107 0.754917 11.00000 0.13426 HKLF 4 REM mcg1662_a.res in P-1 REM R1 = 0.0604 for 2399 Fo > 4sig(Fo) and 0.0791 for all 3148 data REM 252 parameters refined using 2 restraints END WGHT 0.0810 0.3878 REM Highest difference peak 0.434, deepest hole -0.258, 1-sigma level 0.039 Q1 1 0.6281 0.1247 0.5029 11.00000 0.05 0.43 Q2 1 -0.2043 0.4250 0.7762 11.00000 0.05 0.43 Q3 1 0.6717 0.1286 0.3792 11.00000 0.05 0.27 Q4 1 1.0550 -0.2000 0.3959 11.00000 0.05 0.27 Q5 1 0.1999 0.4400 0.6207 11.00000 0.05 0.20 Q6 1 -0.3282 0.3596 0.8842 11.00000 0.05 0.18 Q7 1 0.0490 0.6924 0.6785 11.00000 0.05 0.17 Q8 1 0.9242 -0.0767 0.4420 11.00000 0.05 0.16 Q9 1 0.2393 0.4108 0.5000 11.00000 0.05 0.15 Q10 1 -0.0572 0.5737 0.7119 11.00000 0.05 0.15 Q11 1 0.1857 0.5827 0.8593 11.00000 0.05 0.14 Q12 1 -0.1896 0.2885 1.0008 11.00000 0.05 0.14 Q13 1 -0.2231 0.2464 0.9646 11.00000 0.05 0.13 Q14 1 0.2806 0.3844 0.5157 11.00000 0.05 0.12 Q15 1 -0.1845 0.6080 0.9030 11.00000 0.05 0.12 Q16 1 0.3211 0.4613 0.5416 11.00000 0.05 0.12 Q17 1 0.9667 -0.2177 0.3191 11.00000 0.05 0.12 Q18 1 -0.1645 0.7375 0.8378 11.00000 0.05 0.12 Q19 1 -0.2468 0.4982 0.9165 11.00000 0.05 0.11 Q20 1 -0.5279 0.7413 1.0713 11.00000 0.05 0.11 ; _shelx_res_checksum 28693 _olex2_submission_special_instructions 'No special instructions were received' _chemical_properties_physical Photo-sensitive ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_mcg18136d _database_code_depnum_ccdc_archive 'CCDC 1895859' loop_ _audit_author_name _audit_author_address 'Dale C. Swenson' ;University of Iowa United States of America ; _audit_update_record ; 2019-02-06 deposited with the CCDC. 2020-03-09 downloaded from the CCDC. ; _audit_creation_date 2019-02-04 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic ? _chemical_formula_moiety '2(C8 H8 O5), C24 H20 N4, C4 H8 O' _chemical_formula_sum 'C44 H44 N4 O11' _chemical_formula_weight 804.83 _chemical_absolute_configuration unk _chemical_melting_point ? loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system orthorhombic _space_group_IT_number 19 _space_group_name_H-M_alt 'P 21 21 21' _space_group_name_Hall 'P 2ac 2ab' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x+1/2, -y, z+1/2' '-x, y+1/2, -z+1/2' 'x+1/2, -y+1/2, -z' _cell_length_a 10.9162(11) _cell_length_b 11.3807(11) _cell_length_c 31.809(3) _cell_angle_alpha 90 _cell_angle_beta 90 _cell_angle_gamma 90 _cell_volume 3951.8(7) _cell_formula_units_Z 4 _cell_measurement_reflns_used 8057 _cell_measurement_temperature 150(2) _cell_measurement_theta_max 46.14 _cell_measurement_theta_min 4.401 _shelx_estimated_absorpt_T_max 0.995 _shelx_estimated_absorpt_T_min 0.984 _exptl_absorpt_coefficient_mu 0.098 _exptl_absorpt_correction_T_max 0.7454 _exptl_absorpt_correction_T_min 0.6988 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; SADABS-2014/5 (Bruker,2014/5) was used for absorption correction. wR2(int) was 0.0567 before and 0.0511 after correction. The Ratio of minimum to maximum transmission is 0.9375. The \l/2 correction factor is 0.00150. ; _exptl_absorpt_special_details ? _exptl_crystal_colour colorless _exptl_crystal_density_diffrn 1.353 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description plate _exptl_crystal_F_000 1696 _exptl_crystal_size_max 0.17 _exptl_crystal_size_mid 0.15 _exptl_crystal_size_min 0.05 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0491 _diffrn_reflns_av_unetI/netI 0.0412 _diffrn_reflns_Laue_measured_fraction_full 0.999 _diffrn_reflns_Laue_measured_fraction_max 0.999 _diffrn_reflns_limit_h_max 12 _diffrn_reflns_limit_h_min -12 _diffrn_reflns_limit_k_max 13 _diffrn_reflns_limit_k_min -13 _diffrn_reflns_limit_l_max 37 _diffrn_reflns_limit_l_min -37 _diffrn_reflns_number 40673 _diffrn_reflns_point_group_measured_fraction_full 0.999 _diffrn_reflns_point_group_measured_fraction_max 0.999 _diffrn_reflns_theta_full 24.996 _diffrn_reflns_theta_max 24.996 _diffrn_reflns_theta_min 1.280 _diffrn_ambient_temperature 150.15 _diffrn_detector_area_resol_mean ? _diffrn_measured_fraction_theta_full 0.999 _diffrn_measured_fraction_theta_max 0.999 _diffrn_measurement_device_type 'Nonius APEX II Kappa' _diffrn_measurement_method ? _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_source ? _reflns_Friedel_coverage 0.774 _reflns_Friedel_fraction_full 1.000 _reflns_Friedel_fraction_max 1.000 _reflns_number_gt 5696 _reflns_number_total 6949 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ? _computing_data_collection ? _computing_data_reduction ? _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution ? _refine_diff_density_max 0.859 _refine_diff_density_min -0.404 _refine_diff_density_rms 0.061 _refine_ls_abs_structure_details ; Flack x determined using 2140 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259). ; _refine_ls_abs_structure_Flack -0.1(4) _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.063 _refine_ls_hydrogen_treatment mixed _refine_ls_matrix_type full _refine_ls_number_parameters 584 _refine_ls_number_reflns 6949 _refine_ls_number_restraints 83 _refine_ls_R_factor_all 0.0762 _refine_ls_R_factor_gt 0.0591 _refine_ls_restrained_S_all 1.077 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0920P)^2^+2.7214P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1526 _refine_ls_wR_factor_ref 0.1645 _refine_special_details ? _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups At 1.5 times of: All O(H) groups 2. Restrained distances O4-H4 0.85 with sigma of 0.02 H4-O4 0.85 with sigma of 0.02 C41-C42 = C42-C43 = C43-C44 1.54 with sigma of 0.02 C41-O9 = O9-C44 1.46 with sigma of 0.02 O9-C41 \\sim O9'-C41 \\sim O9-C44 \\sim O9'-C44 with sigma of 0.02 3. Rigid body (RIGU) restrains O9, C41, C42, C43, C44, O9', C41', C42', C43', C44' with sigma for 1-2 distances of 0.004 and sigma for 1-3 distances of 0.004 4. Same fragment restrains {O9, C41, C42, C43, C44} sigma for 1-2: 0.002, 1-3: 0.002 as {O9', C41', C42', C43', C44'} 5. Others Sof(O9')=Sof(C41')=Sof(H41C)=Sof(H41D)=Sof(C42')=Sof(H42C)=Sof(H42D)= Sof(C43')=Sof(H43C)=Sof(H43D)=Sof(C44')=Sof(H44C)=Sof(H44D)=1-FVAR(1) Sof(O9)=Sof(C41)=Sof(H41A)=Sof(H41B)=Sof(C42)=Sof(H42A)=Sof(H42B)=Sof(C43)= Sof(H43A)=Sof(H43B)=Sof(C44)=Sof(H44A)=Sof(H44B)=FVAR(1) 6.a Ternary CH refined with riding coordinates: C29(H29), C35(H35), C23(H23), C22(H22), C4(H4A), C8(H8), C1(H1), C11(H11), C5(H5), C14(H14), C10(H10), C15(H15) 6.b Secondary CH2 refined with riding coordinates: C41(H41A,H41B), C42(H42A,H42B), C43(H43A,H43B), C44(H44A,H44B), C41'(H41C, H41D), C42'(H42C,H42D), C43'(H43C,H43D), C44'(H44C,H44D) 6.c Aromatic/amide H refined with riding coordinates: C37(H37), C20(H20), C40(H40), C21(H21), C3(H3), C38(H38), C18(H18), C31(H31), C34(H34), C2(H2A), C39(H39), C28(H28), C12(H12), C17(H17), C33(H33), C26(H26), C32(H32), C25(H25), C27(H27), C13(H13) 6.d Tetrahedral OH refined with riding coordinates: O6(H6) 6.e Idealised tetrahedral OH refined as rotating group: O2(H2), O8(H8A) ; _atom_sites_solution_hydrogens mixed _atom_sites_solution_primary ? _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group O001 O 0.2616(3) 0.5259(3) 1.39665(10) 0.0251(8) Uani 1 1 d . . . . . O002 O 0.6671(3) 0.9549(3) 0.84931(11) 0.0298(8) Uani 1 1 d . . . . . O2 O 0.1759(4) 0.2134(3) 1.33222(11) 0.0378(10) Uani 1 1 d . . . . . H2 H 0.1358 0.2146 1.3097 0.057 Uiso 1 1 calc GR . . . . O4 O 0.4807(4) 0.3348(4) 1.31247(12) 0.0494(12) Uani 1 1 d D . . . . H4 H 0.506(8) 0.369(7) 1.2902(16) 0.09(3) Uiso 1 1 d D . . . . O1 O 0.0561(4) 0.3655(3) 1.34963(12) 0.0397(10) Uani 1 1 d . . . . . O8 O 0.9843(4) 1.0749(4) 0.90479(12) 0.0458(11) Uani 1 1 d . . . . . H8A H 0.9743 1.1314 0.9215 0.069 Uiso 1 1 calc GR . . . . O3 O 0.3124(4) 0.4424(4) 1.30713(12) 0.0482(11) Uani 1 1 d . . . . . O6 O 0.8861(4) 0.7647(4) 0.93524(12) 0.0549(13) Uani 1 1 d . . . . . H6 H 0.8742 0.7165 0.9548 0.082 Uiso 1 1 calc R . . . . N1 N 1.0666(4) 0.2066(4) 1.25993(12) 0.0288(10) Uani 1 1 d . . . . . O7 O 0.8016(4) 1.0149(4) 0.92949(13) 0.0512(12) Uani 1 1 d . . . . . N3 N 0.9985(4) 0.1987(4) 0.97660(13) 0.0317(10) Uani 1 1 d . . . . . N4 N 0.5604(4) 0.3721(5) 1.23403(14) 0.0392(12) Uani 1 1 d . . . . . N2 N 0.8479(6) 0.6598(4) 1.00995(14) 0.0441(13) Uani 1 1 d . . . . . O5 O 0.6867(5) 0.7487(4) 0.92770(14) 0.0592(13) Uani 1 1 d . . . . . C24 C 0.7188(4) 0.3488(4) 1.16545(14) 0.0220(10) Uani 1 1 d . . . . . C19 C 0.9672(4) 0.2348(4) 1.17926(14) 0.0192(10) Uani 1 1 d . . . . . C36 C 0.9913(4) 0.2800(4) 1.05987(14) 0.0212(10) Uani 1 1 d . . . . . C37 C 0.9088(5) 0.1972(4) 1.04502(14) 0.0230(10) Uani 1 1 d . . . . . H37 H 0.8474 0.1666 1.0632 0.028 Uiso 1 1 calc R . . . . C29 C 0.8947(4) 0.4241(4) 1.11354(13) 0.0187(10) Uani 1 1 d . . . . . H29 H 0.9235 0.4705 1.1384 0.022 Uiso 1 1 calc R . . . . C35 C 0.9903(4) 0.3241(4) 1.10469(13) 0.0195(10) Uani 1 1 d . . . . . H35 H 1.0740 0.3434 1.1154 0.023 Uiso 1 1 calc R . . . . C23 C 0.8043(4) 0.3294(4) 1.12911(14) 0.0200(10) Uani 1 1 d . . . . . H23 H 0.7554 0.3010 1.1046 0.024 Uiso 1 1 calc R . . . . C7 C 0.3820(5) 0.3840(5) 1.32760(15) 0.0280(12) Uani 1 1 d . . . . . C22 C 0.9161(4) 0.2447(4) 1.13551(14) 0.0196(10) Uani 1 1 d . . . . . H22 H 0.8999 0.1655 1.1231 0.023 Uiso 1 1 calc R . . . . C30 C 0.8693(5) 0.5079(4) 1.07810(14) 0.0229(10) Uani 1 1 d . . . . . C20 C 1.0312(5) 0.3246(4) 1.19930(15) 0.0255(11) Uani 1 1 d . . . . . H20 H 1.0426 0.3979 1.1856 0.031 Uiso 1 1 calc R . . . . C6 C 0.1472(5) 0.3061(4) 1.35499(16) 0.0283(12) Uani 1 1 d . . . . . C40 C 1.0769(5) 0.3223(5) 1.03108(16) 0.0294(12) Uani 1 1 d . . . . . H40 H 1.1347 0.3803 1.0393 0.035 Uiso 1 1 calc R . . . . C4 C 0.2055(5) 0.4295(4) 1.41877(15) 0.0261(11) Uani 1 1 d . . . . . H4A H 0.1162 0.4392 1.4248 0.031 Uiso 1 1 calc R . . . . C21 C 1.0780(5) 0.3072(4) 1.23886(15) 0.0276(11) Uani 1 1 d . . . . . H21 H 1.1207 0.3701 1.2519 0.033 Uiso 1 1 calc R . . . . C8 C 0.3687(5) 0.3615(4) 1.37444(14) 0.0239(11) Uani 1 1 d . . . . . H8 H 0.4313 0.3033 1.3842 0.029 Uiso 1 1 calc R . . . . C3 C 0.2870(6) 0.4192(4) 1.45726(15) 0.0321(13) Uani 1 1 d . . . . . H3 H 0.2637 0.3948 1.4847 0.039 Uiso 1 1 calc R . . . . C38 C 0.9158(5) 0.1593(5) 1.00400(14) 0.0273(11) Uani 1 1 d . . . . . H38 H 0.8586 0.1019 0.9947 0.033 Uiso 1 1 calc R . . . . C1 C 0.3846(4) 0.4813(5) 1.39814(15) 0.0261(11) Uani 1 1 d . . . . . H1 H 0.4486 0.5348 1.3863 0.031 Uiso 1 1 calc R . . . . C18 C 0.9551(5) 0.1307(4) 1.20104(15) 0.0304(12) Uani 1 1 d . . . . . H18 H 0.9124 0.0665 1.1888 0.036 Uiso 1 1 calc R . . . . C31 C 0.7654(6) 0.5089(5) 1.05438(17) 0.0374(13) Uani 1 1 d . . . . . H31 H 0.6990 0.4583 1.0611 0.045 Uiso 1 1 calc R . . . . C11 C 0.7789(5) 1.0005(5) 0.83247(16) 0.0323(12) Uani 1 1 d . . . . . H11 H 0.7837 1.0881 0.8306 0.039 Uiso 1 1 calc R . . . . C34 C 0.9608(6) 0.5878(4) 1.06781(16) 0.0335(13) Uani 1 1 d . . . . . H34 H 1.0335 0.5915 1.0842 0.040 Uiso 1 1 calc R . . . . C2 C 0.3991(5) 0.4521(5) 1.44428(16) 0.0307(12) Uani 1 1 d . . . . . H2A H 0.4719 0.4562 1.4606 0.037 Uiso 1 1 calc R . . . . C39 C 1.0766(5) 0.2793(5) 0.99072(16) 0.0347(13) Uani 1 1 d . . . . . H39 H 1.1360 0.3090 0.9717 0.042 Uiso 1 1 calc R . . . . C9 C 0.8804(5) 1.0124(5) 0.90230(18) 0.0374(14) Uani 1 1 d . . . . . C28 C 0.7025(6) 0.4539(5) 1.18524(18) 0.0381(14) Uani 1 1 d . . . . . H28 H 0.7452 0.5217 1.1758 0.046 Uiso 1 1 calc R . . . . C5 C 0.2381(4) 0.3252(4) 1.38988(14) 0.0232(11) Uani 1 1 d . . . . . H5 H 0.2444 0.2520 1.4071 0.028 Uiso 1 1 calc R . . . . C12 C 0.7874(5) 0.9355(5) 0.79080(16) 0.0355(13) Uani 1 1 d . . . . . H12 H 0.8211 0.9635 0.7652 0.043 Uiso 1 1 calc R . . . . C17 C 1.0057(6) 0.1201(5) 1.24092(17) 0.0386(14) Uani 1 1 d . . . . . H17 H 0.9966 0.0475 1.2554 0.046 Uiso 1 1 calc R . . . . C14 C 0.6971(6) 0.8332(5) 0.84324(16) 0.0346(13) Uani 1 1 d . . . . . H14 H 0.6300 0.7766 0.8502 0.042 Uiso 1 1 calc R . . . . C33 C 0.9463(6) 0.6611(5) 1.03404(17) 0.0414(15) Uani 1 1 d . . . . . H33 H 1.0099 0.7153 1.0277 0.050 Uiso 1 1 calc R . . . . C10 C 0.8736(5) 0.9418(6) 0.86294(16) 0.0388(15) Uani 1 1 d . . . . . H10 H 0.9560 0.9346 0.8494 0.047 Uiso 1 1 calc R . . . . C26 C 0.5742(6) 0.2699(6) 1.21426(18) 0.0451(16) Uani 1 1 d . . . . . H26 H 0.5277 0.2044 1.2237 0.054 Uiso 1 1 calc R . . . . C32 C 0.7577(6) 0.5857(6) 1.01989(19) 0.0463(16) Uani 1 1 d . . . . . H32 H 0.6858 0.5849 1.0031 0.056 Uiso 1 1 calc R . . . . C25 C 0.6529(6) 0.2545(5) 1.18064(17) 0.0391(14) Uani 1 1 d . . . . . H25 H 0.6616 0.1792 1.1681 0.047 Uiso 1 1 calc R . . . . C27 C 0.6231(6) 0.4614(6) 1.2193(2) 0.0499(17) Uani 1 1 d . . . . . H27 H 0.6137 0.5355 1.2326 0.060 Uiso 1 1 calc R . . . . C16 C 0.7875(7) 0.7781(6) 0.9145(2) 0.0498(17) Uani 1 1 d . . . . . C15 C 0.8143(6) 0.8196(6) 0.86957(16) 0.0410(15) Uani 1 1 d . . . . . H15 H 0.8674 0.7595 0.8557 0.049 Uiso 1 1 calc R . . . . C13 C 0.7381(5) 0.8324(5) 0.79794(17) 0.0385(14) Uani 1 1 d . . . . . H13 H 0.7299 0.7696 0.7785 0.046 Uiso 1 1 calc R . . . . O9 O 0.8633(19) 0.3438(17) 0.8618(5) 0.156(8) Uani 0.59(2) 1 d D U P A 1 C41 C 0.795(2) 0.3557(16) 0.8995(5) 0.109(7) Uani 0.59(2) 1 d D U P A 1 H41A H 0.8503 0.3730 0.9233 0.131 Uiso 0.59(2) 1 calc R . P A 1 H41B H 0.7501 0.2821 0.9056 0.131 Uiso 0.59(2) 1 calc R . P A 1 C42 C 0.7053(17) 0.4566(12) 0.8929(5) 0.083(5) Uani 0.59(2) 1 d D U P A 1 H42A H 0.6192 0.4294 0.8933 0.100 Uiso 0.59(2) 1 calc R . P A 1 H42B H 0.7165 0.5195 0.9141 0.100 Uiso 0.59(2) 1 calc R . P A 1 C43 C 0.7450(14) 0.4956(12) 0.8494(5) 0.076(4) Uani 0.59(2) 1 d D U P A 1 H43A H 0.6723 0.5179 0.8325 0.091 Uiso 0.59(2) 1 calc R . P A 1 H43B H 0.7992 0.5651 0.8516 0.091 Uiso 0.59(2) 1 calc R . P A 1 C44 C 0.807(2) 0.4044(15) 0.8299(5) 0.106(7) Uani 0.59(2) 1 d D U P A 1 H44A H 0.7486 0.3528 0.8147 0.127 Uiso 0.59(2) 1 calc R . P A 1 H44B H 0.8677 0.4351 0.8097 0.127 Uiso 0.59(2) 1 calc R . P A 1 O9' O 0.792(4) 0.311(2) 0.8567(5) 0.31(3) Uani 0.41(2) 1 d D U P A 2 C41' C 0.824(4) 0.321(3) 0.8997(7) 0.169(18) Uani 0.41(2) 1 d D U P A 2 H41C H 0.9142 0.3184 0.9031 0.202 Uiso 0.41(2) 1 calc R . P A 2 H41D H 0.7880 0.2556 0.9161 0.202 Uiso 0.41(2) 1 calc R . P A 2 C42' C 0.774(2) 0.438(2) 0.9151(6) 0.104(9) Uani 0.41(2) 1 d D U P A 2 H42C H 0.7162 0.4284 0.9388 0.125 Uiso 0.41(2) 1 calc R . P A 2 H42D H 0.8405 0.4928 0.9234 0.125 Uiso 0.41(2) 1 calc R . P A 2 C43' C 0.710(4) 0.478(3) 0.8753(11) 0.31(4) Uani 0.41(2) 1 d D U P A 2 H43C H 0.6207 0.4625 0.8776 0.370 Uiso 0.41(2) 1 calc R . P A 2 H43D H 0.7212 0.5640 0.8715 0.370 Uiso 0.41(2) 1 calc R . P A 2 C44' C 0.758(6) 0.418(3) 0.8413(8) 0.41(5) Uani 0.41(2) 1 d D U P A 2 H44C H 0.6959 0.4098 0.8188 0.491 Uiso 0.41(2) 1 calc R . P A 2 H44D H 0.8297 0.4606 0.8297 0.491 Uiso 0.41(2) 1 calc R . P A 2 loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 O001 0.0257(18) 0.0221(18) 0.0275(18) -0.0018(14) 0.0036(15) 0.0040(15) O002 0.030(2) 0.0288(19) 0.0306(19) 0.0063(15) -0.0023(16) 0.0099(16) O2 0.062(3) 0.0271(19) 0.0238(18) -0.0055(16) -0.0174(18) 0.0118(19) O4 0.045(2) 0.079(3) 0.025(2) 0.014(2) 0.0127(19) 0.033(2) O1 0.039(2) 0.037(2) 0.043(2) -0.0024(18) -0.0105(19) 0.0066(19) O8 0.047(2) 0.060(3) 0.030(2) -0.020(2) 0.0159(19) -0.014(2) O3 0.059(3) 0.060(3) 0.026(2) 0.0127(19) 0.009(2) 0.028(2) O6 0.064(3) 0.069(3) 0.031(2) 0.020(2) 0.007(2) 0.036(3) N1 0.040(3) 0.024(2) 0.023(2) 0.0029(18) -0.0056(19) 0.001(2) O7 0.036(2) 0.076(3) 0.041(2) -0.020(2) 0.006(2) 0.000(2) N3 0.036(2) 0.037(2) 0.022(2) -0.0043(19) 0.0061(19) -0.006(2) N4 0.033(3) 0.058(3) 0.027(2) 0.010(2) 0.009(2) 0.012(2) N2 0.076(4) 0.031(3) 0.026(2) 0.004(2) 0.010(3) 0.007(3) O5 0.072(3) 0.058(3) 0.048(3) 0.012(2) 0.012(3) 0.009(3) C24 0.020(2) 0.033(3) 0.014(2) 0.0049(19) -0.0026(19) 0.002(2) C19 0.019(2) 0.022(2) 0.016(2) -0.0005(19) 0.0015(18) -0.0011(19) C36 0.022(2) 0.022(2) 0.019(2) 0.0014(19) 0.001(2) 0.002(2) C37 0.026(3) 0.024(2) 0.019(2) 0.0009(19) 0.003(2) -0.006(2) C29 0.026(3) 0.019(2) 0.011(2) 0.0028(18) 0.0004(18) -0.004(2) C35 0.022(2) 0.021(2) 0.016(2) 0.0000(18) 0.0010(19) -0.005(2) C23 0.022(2) 0.022(2) 0.016(2) 0.0000(18) -0.0013(18) -0.004(2) C7 0.033(3) 0.030(3) 0.021(2) 0.000(2) 0.002(2) 0.011(2) C22 0.021(2) 0.018(2) 0.020(2) -0.0009(18) 0.000(2) -0.001(2) C30 0.036(3) 0.020(2) 0.013(2) 0.0008(19) 0.005(2) 0.003(2) C20 0.035(3) 0.019(2) 0.023(2) -0.001(2) -0.004(2) -0.002(2) C6 0.040(3) 0.021(2) 0.025(3) 0.005(2) 0.001(2) 0.000(2) C40 0.029(3) 0.029(3) 0.030(3) -0.007(2) 0.010(2) -0.008(2) C4 0.026(3) 0.026(3) 0.026(3) -0.004(2) 0.009(2) 0.000(2) C21 0.039(3) 0.022(3) 0.022(2) -0.006(2) -0.006(2) -0.004(2) C8 0.029(3) 0.028(3) 0.014(2) 0.0024(19) 0.002(2) 0.012(2) C3 0.052(4) 0.026(3) 0.018(2) -0.006(2) 0.004(2) 0.002(3) C38 0.030(3) 0.032(3) 0.021(2) -0.004(2) 0.001(2) -0.007(2) C1 0.022(3) 0.034(3) 0.022(2) 0.000(2) 0.002(2) 0.000(2) C18 0.048(3) 0.021(2) 0.023(3) 0.002(2) -0.006(2) -0.010(2) C31 0.044(3) 0.038(3) 0.029(3) 0.008(2) -0.003(3) 0.001(3) C11 0.031(3) 0.035(3) 0.030(3) 0.002(2) 0.000(2) 0.001(3) C34 0.051(4) 0.026(3) 0.024(3) 0.002(2) 0.010(2) -0.004(3) C2 0.036(3) 0.035(3) 0.021(2) -0.006(2) -0.003(2) 0.006(2) C39 0.039(3) 0.037(3) 0.029(3) -0.004(2) 0.014(2) -0.016(3) C9 0.029(3) 0.051(4) 0.033(3) -0.009(3) 0.000(3) 0.009(3) C28 0.047(3) 0.026(3) 0.041(3) 0.003(2) 0.019(3) 0.005(3) C5 0.033(3) 0.020(2) 0.016(2) 0.0021(18) 0.001(2) 0.003(2) C12 0.040(3) 0.050(3) 0.016(2) 0.007(2) -0.006(2) 0.001(3) C17 0.059(4) 0.026(3) 0.030(3) 0.009(2) -0.014(3) -0.015(3) C14 0.048(3) 0.026(3) 0.030(3) 0.005(2) 0.003(3) 0.008(3) C33 0.063(4) 0.032(3) 0.029(3) 0.005(2) 0.010(3) -0.003(3) C10 0.026(3) 0.070(4) 0.021(3) -0.014(3) -0.002(2) 0.018(3) C26 0.044(3) 0.059(4) 0.032(3) 0.004(3) 0.015(3) -0.018(3) C32 0.053(4) 0.053(4) 0.033(3) 0.009(3) -0.010(3) 0.014(3) C25 0.048(4) 0.040(3) 0.030(3) -0.004(2) 0.011(3) -0.016(3) C27 0.059(4) 0.041(3) 0.050(4) -0.004(3) 0.026(3) 0.011(3) C16 0.048(4) 0.062(4) 0.039(3) 0.004(3) 0.002(3) 0.029(4) C15 0.049(4) 0.050(4) 0.024(3) 0.005(2) 0.008(2) 0.029(3) C13 0.047(3) 0.044(3) 0.024(3) -0.002(2) -0.002(2) 0.002(3) O9 0.148(14) 0.174(15) 0.147(12) -0.010(10) 0.019(10) 0.049(12) C41 0.113(14) 0.082(11) 0.132(13) 0.028(10) 0.012(10) -0.008(10) C42 0.104(12) 0.046(7) 0.099(11) -0.010(6) 0.013(9) -0.025(7) C43 0.060(8) 0.067(8) 0.100(10) -0.015(6) -0.002(7) -0.012(6) C44 0.133(15) 0.083(10) 0.103(11) -0.007(8) 0.033(9) 0.011(10) O9' 0.40(7) 0.35(4) 0.18(2) -0.16(2) -0.14(3) 0.26(4) C41' 0.14(4) 0.21(3) 0.16(2) -0.08(2) -0.05(2) 0.04(2) C42' 0.039(12) 0.15(2) 0.125(17) -0.059(15) 0.008(12) -0.020(13) C43' 0.45(9) 0.31(5) 0.17(2) -0.13(2) -0.13(3) 0.23(6) C44' 0.69(12) 0.39(5) 0.15(2) -0.12(2) -0.10(2) 0.35(6) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag O001 C4 1.440(6) . ? O001 C1 1.437(6) . ? O002 C11 1.430(7) . ? O002 C14 1.436(6) . ? O2 H2 0.8400 . ? O2 C6 1.318(6) . ? O4 H4 0.85(2) . ? O4 C7 1.306(6) . ? O1 C6 1.214(6) . ? O8 H8A 0.8400 . ? O8 C9 1.341(7) . ? O3 C7 1.201(6) . ? O6 H6 0.8400 . ? O6 C16 1.272(8) . ? N1 C21 1.332(7) . ? N1 C17 1.333(7) . ? O7 C9 1.220(7) . ? N3 C38 1.333(7) . ? N3 C39 1.331(7) . ? N4 C26 1.331(8) . ? N4 C27 1.313(8) . ? N2 C33 1.319(8) . ? N2 C32 1.335(8) . ? O5 C16 1.225(8) . ? C24 C23 1.502(6) . ? C24 C28 1.363(8) . ? C24 C25 1.380(7) . ? C19 C22 1.503(6) . ? C19 C20 1.392(7) . ? C19 C18 1.379(7) . ? C36 C37 1.387(7) . ? C36 C35 1.511(6) . ? C36 C40 1.394(7) . ? C37 H37 0.9500 . ? C37 C38 1.376(7) . ? C29 H29 1.0000 . ? C29 C35 1.569(7) . ? C29 C23 1.543(6) . ? C29 C30 1.502(6) . ? C35 H35 1.0000 . ? C35 C22 1.560(6) . ? C23 H23 1.0000 . ? C23 C22 1.569(7) . ? C7 C8 1.519(6) . ? C22 H22 1.0000 . ? C30 C31 1.362(8) . ? C30 C34 1.390(7) . ? C20 H20 0.9500 . ? C20 C21 1.372(7) . ? C6 C5 1.504(7) . ? C40 H40 0.9500 . ? C40 C39 1.374(7) . ? C4 H4A 1.0000 . ? C4 C3 1.518(8) . ? C4 C5 1.542(6) . ? C21 H21 0.9500 . ? C8 H8 1.0000 . ? C8 C1 1.568(7) . ? C8 C5 1.564(7) . ? C3 H3 0.9500 . ? C3 C2 1.345(8) . ? C38 H38 0.9500 . ? C1 H1 1.0000 . ? C1 C2 1.513(7) . ? C18 H18 0.9500 . ? C18 C17 1.389(7) . ? C31 H31 0.9500 . ? C31 C32 1.405(8) . ? C11 H11 1.0000 . ? C11 C12 1.521(8) . ? C11 C10 1.567(8) . ? C34 H34 0.9500 . ? C34 C33 1.369(8) . ? C2 H2A 0.9500 . ? C39 H39 0.9500 . ? C9 C10 1.490(8) . ? C28 H28 0.9500 . ? C28 C27 1.389(8) . ? C5 H5 1.0000 . ? C12 H12 0.9500 . ? C12 C13 1.310(9) . ? C17 H17 0.9500 . ? C14 H14 1.0000 . ? C14 C15 1.537(8) . ? C14 C13 1.509(7) . ? C33 H33 0.9500 . ? C10 H10 1.0000 . ? C10 C15 1.549(9) . ? C26 H26 0.9500 . ? C26 C25 1.383(8) . ? C32 H32 0.9500 . ? C25 H25 0.9500 . ? C27 H27 0.9500 . ? C16 C15 1.532(8) . ? C15 H15 1.0000 . ? C13 H13 0.9500 . ? O9 C41 1.418(14) . ? O9 C44 1.372(15) . ? C41 H41A 0.9900 . ? C41 H41B 0.9900 . ? C41 C42 1.523(18) . ? C42 H42A 0.9900 . ? C42 H42B 0.9900 . ? C42 C43 1.518(18) . ? C43 H43A 0.9900 . ? C43 H43B 0.9900 . ? C43 C44 1.383(17) . ? C44 H44A 0.9900 . ? C44 H44B 0.9900 . ? O9' C41' 1.418(15) . ? O9' C44' 1.373(15) . ? C41' H41C 0.9900 . ? C41' H41D 0.9900 . ? C41' C42' 1.523(18) . ? C42' H42C 0.9900 . ? C42' H42D 0.9900 . ? C42' C43' 1.517(18) . ? C43' H43C 0.9900 . ? C43' H43D 0.9900 . ? C43' C44' 1.384(17) . ? C44' H44C 0.9900 . ? C44' H44D 0.9900 . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C1 O001 C4 96.5(4) . . ? C11 O002 C14 96.0(4) . . ? C6 O2 H2 109.5 . . ? C7 O4 H4 112(6) . . ? C9 O8 H8A 109.5 . . ? C16 O6 H6 109.5 . . ? C21 N1 C17 116.9(4) . . ? C39 N3 C38 116.5(4) . . ? C27 N4 C26 116.7(5) . . ? C33 N2 C32 118.1(5) . . ? C28 C24 C23 124.4(5) . . ? C28 C24 C25 116.9(5) . . ? C25 C24 C23 118.6(5) . . ? C20 C19 C22 123.7(4) . . ? C18 C19 C22 119.6(4) . . ? C18 C19 C20 116.6(4) . . ? C37 C36 C35 122.8(4) . . ? C37 C36 C40 116.5(4) . . ? C40 C36 C35 120.7(4) . . ? C36 C37 H37 120.0 . . ? C38 C37 C36 120.0(4) . . ? C38 C37 H37 120.0 . . ? C35 C29 H29 108.4 . . ? C23 C29 H29 108.4 . . ? C23 C29 C35 88.6(3) . . ? C30 C29 H29 108.4 . . ? C30 C29 C35 116.6(4) . . ? C30 C29 C23 124.4(4) . . ? C36 C35 C29 114.6(4) . . ? C36 C35 H35 112.8 . . ? C36 C35 C22 113.8(4) . . ? C29 C35 H35 112.8 . . ? C22 C35 C29 87.8(3) . . ? C22 C35 H35 112.8 . . ? C24 C23 C29 122.8(4) . . ? C24 C23 H23 108.5 . . ? C24 C23 C22 118.3(4) . . ? C29 C23 H23 108.5 . . ? C29 C23 C22 88.5(3) . . ? C22 C23 H23 108.5 . . ? O4 C7 C8 111.6(4) . . ? O3 C7 O4 124.0(5) . . ? O3 C7 C8 124.4(5) . . ? C19 C22 C35 115.6(4) . . ? C19 C22 C23 117.0(4) . . ? C19 C22 H22 111.4 . . ? C35 C22 C23 88.0(3) . . ? C35 C22 H22 111.4 . . ? C23 C22 H22 111.4 . . ? C31 C30 C29 125.1(5) . . ? C31 C30 C34 117.5(5) . . ? C34 C30 C29 117.3(5) . . ? C19 C20 H20 120.0 . . ? C21 C20 C19 120.1(5) . . ? C21 C20 H20 120.0 . . ? O2 C6 C5 111.4(4) . . ? O1 C6 O2 124.3(5) . . ? O1 C6 C5 124.3(5) . . ? C36 C40 H40 120.3 . . ? C39 C40 C36 119.3(5) . . ? C39 C40 H40 120.3 . . ? O001 C4 H4A 115.1 . . ? O001 C4 C3 101.7(4) . . ? O001 C4 C5 101.4(3) . . ? C3 C4 H4A 115.1 . . ? C3 C4 C5 106.6(4) . . ? C5 C4 H4A 115.1 . . ? N1 C21 C20 123.4(5) . . ? N1 C21 H21 118.3 . . ? C20 C21 H21 118.3 . . ? C7 C8 H8 110.5 . . ? C7 C8 C1 108.3(4) . . ? C7 C8 C5 116.1(4) . . ? C1 C8 H8 110.5 . . ? C5 C8 H8 110.5 . . ? C5 C8 C1 100.3(4) . . ? C4 C3 H3 127.3 . . ? C2 C3 C4 105.3(4) . . ? C2 C3 H3 127.3 . . ? N3 C38 C37 123.5(5) . . ? N3 C38 H38 118.2 . . ? C37 C38 H38 118.2 . . ? O001 C1 C8 100.8(4) . . ? O001 C1 H1 115.2 . . ? O001 C1 C2 101.9(4) . . ? C8 C1 H1 115.2 . . ? C2 C1 C8 106.7(4) . . ? C2 C1 H1 115.2 . . ? C19 C18 H18 120.1 . . ? C19 C18 C17 119.7(5) . . ? C17 C18 H18 120.1 . . ? C30 C31 H31 120.4 . . ? C30 C31 C32 119.2(6) . . ? C32 C31 H31 120.4 . . ? O002 C11 H11 115.4 . . ? O002 C11 C12 101.6(4) . . ? O002 C11 C10 100.2(4) . . ? C12 C11 H11 115.4 . . ? C12 C11 C10 106.9(4) . . ? C10 C11 H11 115.4 . . ? C30 C34 H34 120.0 . . ? C33 C34 C30 120.0(6) . . ? C33 C34 H34 120.0 . . ? C3 C2 C1 105.3(5) . . ? C3 C2 H2A 127.3 . . ? C1 C2 H2A 127.3 . . ? N3 C39 C40 124.2(5) . . ? N3 C39 H39 117.9 . . ? C40 C39 H39 117.9 . . ? O8 C9 C10 112.2(5) . . ? O7 C9 O8 122.8(5) . . ? O7 C9 C10 125.0(6) . . ? C24 C28 H28 120.2 . . ? C24 C28 C27 119.7(5) . . ? C27 C28 H28 120.2 . . ? C6 C5 C4 113.5(4) . . ? C6 C5 C8 114.1(4) . . ? C6 C5 H5 109.2 . . ? C4 C5 C8 101.2(4) . . ? C4 C5 H5 109.2 . . ? C8 C5 H5 109.2 . . ? C11 C12 H12 127.5 . . ? C13 C12 C11 105.0(5) . . ? C13 C12 H12 127.5 . . ? N1 C17 C18 123.2(5) . . ? N1 C17 H17 118.4 . . ? C18 C17 H17 118.4 . . ? O002 C14 H14 115.1 . . ? O002 C14 C15 102.3(5) . . ? O002 C14 C13 101.6(4) . . ? C15 C14 H14 115.1 . . ? C13 C14 H14 115.1 . . ? C13 C14 C15 105.8(5) . . ? N2 C33 C34 122.9(6) . . ? N2 C33 H33 118.6 . . ? C34 C33 H33 118.6 . . ? C11 C10 H10 111.2 . . ? C9 C10 C11 108.8(5) . . ? C9 C10 H10 111.2 . . ? C9 C10 C15 113.0(5) . . ? C15 C10 C11 101.0(4) . . ? C15 C10 H10 111.2 . . ? N4 C26 H26 118.5 . . ? N4 C26 C25 123.1(6) . . ? C25 C26 H26 118.5 . . ? N2 C32 C31 122.3(6) . . ? N2 C32 H32 118.9 . . ? C31 C32 H32 118.9 . . ? C24 C25 C26 119.8(5) . . ? C24 C25 H25 120.1 . . ? C26 C25 H25 120.1 . . ? N4 C27 C28 123.8(6) . . ? N4 C27 H27 118.1 . . ? C28 C27 H27 118.1 . . ? O6 C16 C15 111.1(6) . . ? O5 C16 O6 123.3(6) . . ? O5 C16 C15 125.1(6) . . ? C14 C15 C10 100.6(4) . . ? C14 C15 H15 108.1 . . ? C10 C15 H15 108.1 . . ? C16 C15 C14 112.4(5) . . ? C16 C15 C10 118.9(5) . . ? C16 C15 H15 108.1 . . ? C12 C13 C14 106.4(5) . . ? C12 C13 H13 126.8 . . ? C14 C13 H13 126.8 . . ? C44 O9 C41 109.8(15) . . ? O9 C41 H41A 110.3 . . ? O9 C41 H41B 110.3 . . ? O9 C41 C42 107.1(12) . . ? H41A C41 H41B 108.5 . . ? C42 C41 H41A 110.3 . . ? C42 C41 H41B 110.3 . . ? C41 C42 H42A 111.9 . . ? C41 C42 H42B 111.9 . . ? H42A C42 H42B 109.6 . . ? C43 C42 C41 99.3(11) . . ? C43 C42 H42A 111.9 . . ? C43 C42 H42B 111.9 . . ? C42 C43 H43A 109.9 . . ? C42 C43 H43B 109.9 . . ? H43A C43 H43B 108.3 . . ? C44 C43 C42 109.1(13) . . ? C44 C43 H43A 109.9 . . ? C44 C43 H43B 109.9 . . ? O9 C44 C43 105.5(14) . . ? O9 C44 H44A 110.6 . . ? O9 C44 H44B 110.6 . . ? C43 C44 H44A 110.6 . . ? C43 C44 H44B 110.6 . . ? H44A C44 H44B 108.8 . . ? C44' O9' C41' 109.7(15) . . ? O9' C41' H41C 110.3 . . ? O9' C41' H41D 110.3 . . ? O9' C41' C42' 107.1(13) . . ? H41C C41' H41D 108.6 . . ? C42' C41' H41C 110.3 . . ? C42' C41' H41D 110.3 . . ? C41' C42' H42C 111.9 . . ? C41' C42' H42D 111.9 . . ? H42C C42' H42D 109.6 . . ? C43' C42' C41' 99.4(11) . . ? C43' C42' H42C 111.9 . . ? C43' C42' H42D 111.9 . . ? C42' C43' H43C 109.9 . . ? C42' C43' H43D 109.9 . . ? H43C C43' H43D 108.3 . . ? C44' C43' C42' 109.1(13) . . ? C44' C43' H43C 109.9 . . ? C44' C43' H43D 109.9 . . ? O9' C44' C43' 105.3(14) . . ? O9' C44' H44C 110.7 . . ? O9' C44' H44D 110.7 . . ? C43' C44' H44C 110.7 . . ? C43' C44' H44D 110.7 . . ? H44C C44' H44D 108.8 . . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag O001 C4 C3 C2 -31.8(5) . . . . ? O001 C4 C5 C6 -86.9(5) . . . . ? O001 C4 C5 C8 35.8(4) . . . . ? O001 C1 C2 C3 32.3(5) . . . . ? O002 C11 C12 C13 -33.1(6) . . . . ? O002 C11 C10 C9 -81.8(6) . . . . ? O002 C11 C10 C15 37.4(5) . . . . ? O002 C14 C15 C10 -34.5(5) . . . . ? O002 C14 C15 C16 93.0(6) . . . . ? O002 C14 C13 C12 31.2(6) . . . . ? O2 C6 C5 C4 -177.3(4) . . . . ? O2 C6 C5 C8 67.4(5) . . . . ? O4 C7 C8 C1 112.9(5) . . . . ? O4 C7 C8 C5 -135.3(5) . . . . ? O1 C6 C5 C4 -0.4(7) . . . . ? O1 C6 C5 C8 -115.6(6) . . . . ? O8 C9 C10 C11 -106.3(6) . . . . ? O8 C9 C10 C15 142.3(5) . . . . ? O3 C7 C8 C1 -65.3(7) . . . . ? O3 C7 C8 C5 46.6(7) . . . . ? O6 C16 C15 C14 178.3(5) . . . . ? O6 C16 C15 C10 -64.7(7) . . . . ? O7 C9 C10 C11 73.4(8) . . . . ? O7 C9 C10 C15 -37.9(8) . . . . ? N4 C26 C25 C24 -2.0(10) . . . . ? O5 C16 C15 C14 6.1(9) . . . . ? O5 C16 C15 C10 123.1(7) . . . . ? C24 C23 C22 C19 -29.0(6) . . . . ? C24 C23 C22 C35 -146.9(4) . . . . ? C24 C28 C27 N4 -0.4(10) . . . . ? C19 C20 C21 N1 0.5(8) . . . . ? C19 C18 C17 N1 0.1(10) . . . . ? C36 C37 C38 N3 -0.6(8) . . . . ? C36 C35 C22 C19 144.4(4) . . . . ? C36 C35 C22 C23 -96.4(4) . . . . ? C36 C40 C39 N3 0.4(9) . . . . ? C37 C36 C35 C29 -82.2(5) . . . . ? C37 C36 C35 C22 16.8(6) . . . . ? C37 C36 C40 C39 -1.3(8) . . . . ? C29 C35 C22 C19 -99.6(4) . . . . ? C29 C35 C22 C23 19.6(3) . . . . ? C29 C23 C22 C19 98.0(4) . . . . ? C29 C23 C22 C35 -19.9(3) . . . . ? C29 C30 C31 C32 -174.7(5) . . . . ? C29 C30 C34 C33 175.7(5) . . . . ? C35 C36 C37 C38 -179.0(5) . . . . ? C35 C36 C40 C39 179.1(5) . . . . ? C35 C29 C23 C24 142.9(4) . . . . ? C35 C29 C23 C22 19.8(3) . . . . ? C35 C29 C30 C31 106.1(6) . . . . ? C35 C29 C30 C34 -71.6(6) . . . . ? C23 C24 C28 C27 -178.4(5) . . . . ? C23 C24 C25 C26 179.6(5) . . . . ? C23 C29 C35 C36 95.4(4) . . . . ? C23 C29 C35 C22 -19.9(3) . . . . ? C23 C29 C30 C31 -2.1(7) . . . . ? C23 C29 C30 C34 -179.7(4) . . . . ? C7 C8 C1 O001 86.2(5) . . . . ? C7 C8 C1 C2 -167.7(4) . . . . ? C7 C8 C5 C6 5.9(6) . . . . ? C7 C8 C5 C4 -116.3(4) . . . . ? C22 C19 C20 C21 -178.1(5) . . . . ? C22 C19 C18 C17 177.9(5) . . . . ? C30 C29 C35 C36 -33.0(6) . . . . ? C30 C29 C35 C22 -148.3(4) . . . . ? C30 C29 C23 C24 -95.2(5) . . . . ? C30 C29 C23 C22 141.6(4) . . . . ? C30 C31 C32 N2 -1.4(9) . . . . ? C30 C34 C33 N2 -0.3(8) . . . . ? C20 C19 C22 C35 31.7(7) . . . . ? C20 C19 C22 C23 -70.0(6) . . . . ? C20 C19 C18 C17 0.1(8) . . . . ? C40 C36 C37 C38 1.4(7) . . . . ? C40 C36 C35 C29 97.4(5) . . . . ? C40 C36 C35 C22 -163.6(4) . . . . ? C4 O001 C1 C8 59.4(4) . . . . ? C4 O001 C1 C2 -50.4(4) . . . . ? C4 C3 C2 C1 -0.3(5) . . . . ? C21 N1 C17 C18 0.0(9) . . . . ? C8 C1 C2 C3 -72.9(5) . . . . ? C3 C4 C5 C6 167.0(4) . . . . ? C3 C4 C5 C8 -70.3(5) . . . . ? C38 N3 C39 C40 0.4(8) . . . . ? C1 O001 C4 C3 50.1(4) . . . . ? C1 O001 C4 C5 -59.8(4) . . . . ? C1 C8 C5 C6 122.3(4) . . . . ? C1 C8 C5 C4 0.1(4) . . . . ? C18 C19 C22 C35 -145.9(5) . . . . ? C18 C19 C22 C23 112.4(5) . . . . ? C18 C19 C20 C21 -0.4(7) . . . . ? C31 C30 C34 C33 -2.1(8) . . . . ? C11 O002 C14 C15 59.6(4) . . . . ? C11 O002 C14 C13 -49.7(5) . . . . ? C11 C12 C13 C14 1.0(6) . . . . ? C11 C10 C15 C14 -1.7(5) . . . . ? C11 C10 C15 C16 -124.8(5) . . . . ? C34 C30 C31 C32 2.9(8) . . . . ? C39 N3 C38 C37 -0.3(8) . . . . ? C9 C10 C15 C14 114.4(5) . . . . ? C9 C10 C15 C16 -8.7(7) . . . . ? C28 C24 C23 C29 7.4(8) . . . . ? C28 C24 C23 C22 115.5(6) . . . . ? C28 C24 C25 C26 0.5(8) . . . . ? C5 C4 C3 C2 74.0(5) . . . . ? C5 C8 C1 O001 -35.9(4) . . . . ? C5 C8 C1 C2 70.2(5) . . . . ? C12 C11 C10 C9 172.6(5) . . . . ? C12 C11 C10 C15 -68.2(5) . . . . ? C17 N1 C21 C20 -0.3(8) . . . . ? C14 O002 C11 C12 50.4(4) . . . . ? C14 O002 C11 C10 -59.5(4) . . . . ? C33 N2 C32 C31 -1.1(9) . . . . ? C10 C11 C12 C13 71.4(6) . . . . ? C26 N4 C27 C28 -1.0(10) . . . . ? C32 N2 C33 C34 1.9(9) . . . . ? C25 C24 C23 C29 -171.6(5) . . . . ? C25 C24 C23 C22 -63.5(6) . . . . ? C25 C24 C28 C27 0.6(9) . . . . ? C27 N4 C26 C25 2.1(9) . . . . ? C15 C14 C13 C12 -75.3(6) . . . . ? C13 C14 C15 C10 71.6(5) . . . . ? C13 C14 C15 C16 -161.0(5) . . . . ? O9 C41 C42 C43 -4(2) . . . . ? C41 O9 C44 C43 29(2) . . . . ? C41 C42 C43 C44 21.0(19) . . . . ? C42 C43 C44 O9 -31(2) . . . . ? C44 O9 C41 C42 -15(3) . . . . ? O9' C41' C42' C43' 3(2) . . . . ? C41' O9' C44' C43' -29(3) . . . . ? C41' C42' C43' C44' -21(2) . . . . ? C42' C43' C44' O9' 31(2) . . . . ? C44' O9' C41' C42' 16(3) . . . . ? _shelx_res_file ; mcg18136d.res created by SHELXL-2014/7 TITL mcg18136_a.res in P2(1)2(1)2(1) REM Old TITL Mcg18_136 in P2(1)2(1)2(1) sample #18191 SY-MFA-4,4-tpcb-rpt REM SHELXT solution in P2(1)2(1)2(1) REM R1 0.153, Rweak 0.042, Alpha 0.009, Orientation as input REM Flack x = -0.386 ( 0.347 ) from Parsons' quotients REM Formula found by SHELXT: C45 N5 O9 rem EADP C41 C41' rem EADP C42 C42' rem EADP C43 C43' rem EADP C44 C44' CELL 0.71073 10.9162 11.3807 31.809 90 90 90 ZERR 4 0.0011 0.0011 0.003 0 0 0 LATT -1 SYMM 0.5-X,-Y,0.5+Z SYMM -X,0.5+Y,0.5-Z SYMM 0.5+X,0.5-Y,-Z SFAC C H N O UNIT 176 176 16 44 DFIX 0.85 O4 H4 DFIX 0.85 H4 O4 DFIX 1.54 C41 C42 C42 C43 C43 C44 DFIX 1.46 C41 O9 O9 C44 SADI O9 C41 O9' C41 O9 C44 O9' C44 RIGU O9 > C44' L.S. 10 PLAN -20 SIZE 0.05 0.15 0.17 TEMP -123 BOND $H list 4 conf fmap 2 acta OMIT -2 50 OMIT 1 0 1 OMIT 1 3 0 OMIT 0 0 4 REM REM REM WGHT 0.092000 2.721400 FVAR 0.42040 0.58945 O001 4 0.261563 0.525856 1.396651 11.00000 0.02573 0.02211 = 0.02748 -0.00176 0.00364 0.00397 O002 4 0.667117 0.954864 0.849310 11.00000 0.02990 0.02876 = 0.03060 0.00631 -0.00229 0.00989 O2 4 0.175888 0.213412 1.332222 11.00000 0.06239 0.02714 = 0.02380 -0.00549 -0.01744 0.01183 AFIX 147 H2 2 0.135849 0.214561 1.309675 11.00000 -1.50000 AFIX 0 O4 4 0.480689 0.334835 1.312475 11.00000 0.04476 0.07868 = 0.02481 0.01355 0.01270 0.03295 H4 2 0.505524 0.368521 1.290204 11.00000 0.08662 O1 4 0.056112 0.365514 1.349629 11.00000 0.03944 0.03719 = 0.04254 -0.00239 -0.01046 0.00664 O8 4 0.984312 1.074928 0.904793 11.00000 0.04705 0.05988 = 0.03047 -0.01984 0.01592 -0.01444 AFIX 147 H8A 2 0.974335 1.131377 0.921459 11.00000 -1.50000 AFIX 0 O3 4 0.312361 0.442394 1.307127 11.00000 0.05915 0.05960 = 0.02578 0.01272 0.00901 0.02786 O6 4 0.886073 0.764717 0.935244 11.00000 0.06424 0.06944 = 0.03101 0.01954 0.00736 0.03631 AFIX 83 H6 2 0.874211 0.716547 0.954834 11.00000 -1.50000 AFIX 0 N1 3 1.066585 0.206620 1.259931 11.00000 0.03978 0.02404 = 0.02265 0.00290 -0.00564 0.00069 O7 4 0.801619 1.014925 0.929495 11.00000 0.03597 0.07649 = 0.04127 -0.02049 0.00603 -0.00048 N3 3 0.998455 0.198667 0.976604 11.00000 0.03642 0.03696 = 0.02172 -0.00433 0.00614 -0.00630 N4 3 0.560413 0.372063 1.234031 11.00000 0.03270 0.05798 = 0.02690 0.01046 0.00942 0.01175 N2 3 0.847946 0.659827 1.009953 11.00000 0.07563 0.03082 = 0.02597 0.00437 0.00960 0.00730 O5 4 0.686750 0.748675 0.927703 11.00000 0.07182 0.05788 = 0.04793 0.01175 0.01202 0.00942 C24 1 0.718821 0.348818 1.165446 11.00000 0.01966 0.03258 = 0.01364 0.00489 -0.00256 0.00170 C19 1 0.967186 0.234842 1.179259 11.00000 0.01910 0.02221 = 0.01642 -0.00051 0.00146 -0.00112 C36 1 0.991332 0.279954 1.059874 11.00000 0.02195 0.02230 = 0.01928 0.00141 0.00137 0.00226 C37 1 0.908761 0.197173 1.045019 11.00000 0.02625 0.02416 = 0.01859 0.00088 0.00312 -0.00595 AFIX 43 H37 2 0.847377 0.166640 1.063153 11.00000 -1.20000 AFIX 0 C29 1 0.894736 0.424114 1.113544 11.00000 0.02579 0.01948 = 0.01094 0.00279 0.00043 -0.00443 AFIX 13 H29 2 0.923483 0.470462 1.138364 11.00000 -1.20000 AFIX 0 C35 1 0.990270 0.324112 1.104686 11.00000 0.02156 0.02069 = 0.01614 0.00000 0.00098 -0.00491 AFIX 13 H35 2 1.074016 0.343381 1.115401 11.00000 -1.20000 AFIX 0 C23 1 0.804301 0.329438 1.129109 11.00000 0.02190 0.02217 = 0.01603 -0.00003 -0.00134 -0.00381 AFIX 13 H23 2 0.755414 0.300953 1.104553 11.00000 -1.20000 AFIX 0 C7 1 0.381980 0.384024 1.327604 11.00000 0.03313 0.03032 = 0.02051 0.00013 0.00164 0.01054 C22 1 0.916096 0.244688 1.135509 11.00000 0.02099 0.01807 = 0.01967 -0.00090 -0.00035 -0.00140 AFIX 13 H22 2 0.899893 0.165513 1.123060 11.00000 -1.20000 AFIX 0 C30 1 0.869303 0.507870 1.078102 11.00000 0.03638 0.01965 = 0.01259 0.00082 0.00489 0.00273 C20 1 1.031234 0.324551 1.199296 11.00000 0.03474 0.01914 = 0.02268 -0.00084 -0.00372 -0.00193 AFIX 43 H20 2 1.042596 0.397881 1.185569 11.00000 -1.20000 AFIX 0 C6 1 0.147217 0.306125 1.354994 11.00000 0.03960 0.02052 = 0.02491 0.00488 0.00088 0.00007 C40 1 1.076859 0.322281 1.031076 11.00000 0.02872 0.02910 = 0.03038 -0.00711 0.00984 -0.00794 AFIX 43 H40 2 1.134724 0.380271 1.039270 11.00000 -1.20000 AFIX 0 C4 1 0.205490 0.429464 1.418765 11.00000 0.02640 0.02583 = 0.02619 -0.00448 0.00903 0.00046 AFIX 13 H4A 2 0.116165 0.439150 1.424817 11.00000 -1.20000 AFIX 0 C21 1 1.077982 0.307180 1.238857 11.00000 0.03865 0.02206 = 0.02211 -0.00570 -0.00590 -0.00386 AFIX 43 H21 2 1.120687 0.370131 1.251892 11.00000 -1.20000 AFIX 0 C8 1 0.368744 0.361457 1.374444 11.00000 0.02942 0.02818 = 0.01415 0.00237 0.00189 0.01179 AFIX 13 H8 2 0.431291 0.303323 1.384189 11.00000 -1.20000 AFIX 0 C3 1 0.286985 0.419234 1.457263 11.00000 0.05195 0.02602 = 0.01828 -0.00610 0.00426 0.00235 AFIX 43 H3 2 0.263739 0.394797 1.484684 11.00000 -1.20000 AFIX 0 C38 1 0.915752 0.159260 1.004002 11.00000 0.02953 0.03153 = 0.02071 -0.00373 0.00098 -0.00732 AFIX 43 H38 2 0.858559 0.101932 0.994727 11.00000 -1.20000 AFIX 0 C1 1 0.384642 0.481321 1.398139 11.00000 0.02199 0.03438 = 0.02203 -0.00022 0.00171 -0.00030 AFIX 13 H1 2 0.448615 0.534811 1.386303 11.00000 -1.20000 AFIX 0 C18 1 0.955123 0.130678 1.201038 11.00000 0.04786 0.02053 = 0.02267 0.00222 -0.00607 -0.01048 AFIX 43 H18 2 0.912388 0.066485 1.188815 11.00000 -1.20000 AFIX 0 C31 1 0.765400 0.508918 1.054378 11.00000 0.04437 0.03845 = 0.02931 0.00830 -0.00329 0.00091 AFIX 43 H31 2 0.698968 0.458341 1.061068 11.00000 -1.20000 AFIX 0 C11 1 0.778920 1.000494 0.832469 11.00000 0.03134 0.03548 = 0.03011 0.00229 -0.00041 0.00057 AFIX 13 H11 2 0.783652 1.088081 0.830553 11.00000 -1.20000 AFIX 0 C34 1 0.960844 0.587809 1.067807 11.00000 0.05105 0.02558 = 0.02372 0.00168 0.00963 -0.00411 AFIX 43 H34 2 1.033475 0.591550 1.084205 11.00000 -1.20000 AFIX 0 C2 1 0.399113 0.452142 1.444278 11.00000 0.03601 0.03539 = 0.02080 -0.00609 -0.00278 0.00599 AFIX 43 H2A 2 0.471878 0.456198 1.460596 11.00000 -1.20000 AFIX 0 C39 1 1.076612 0.279273 0.990723 11.00000 0.03897 0.03654 = 0.02854 -0.00433 0.01383 -0.01552 AFIX 43 H39 2 1.136049 0.308980 0.971672 11.00000 -1.20000 AFIX 0 C9 1 0.880418 1.012426 0.902299 11.00000 0.02874 0.05089 = 0.03269 -0.00940 0.00000 0.00931 C28 1 0.702526 0.453937 1.185236 11.00000 0.04708 0.02650 = 0.04074 0.00330 0.01934 0.00452 AFIX 43 H28 2 0.745242 0.521712 1.175797 11.00000 -1.20000 AFIX 0 C5 1 0.238103 0.325234 1.389878 11.00000 0.03346 0.02037 = 0.01581 0.00215 0.00052 0.00292 AFIX 13 H5 2 0.244373 0.252031 1.407133 11.00000 -1.20000 AFIX 0 C12 1 0.787384 0.935470 0.790801 11.00000 0.03982 0.05046 = 0.01624 0.00669 -0.00585 0.00078 AFIX 43 H12 2 0.821078 0.963504 0.765156 11.00000 -1.20000 AFIX 0 C17 1 1.005748 0.120066 1.240924 11.00000 0.05882 0.02642 = 0.03042 0.00909 -0.01437 -0.01499 AFIX 43 H17 2 0.996557 0.047539 1.255370 11.00000 -1.20000 AFIX 0 C14 1 0.697099 0.833179 0.843239 11.00000 0.04843 0.02581 = 0.02971 0.00478 0.00285 0.00753 AFIX 13 H14 2 0.630000 0.776589 0.850177 11.00000 -1.20000 AFIX 0 C33 1 0.946347 0.661149 1.034039 11.00000 0.06310 0.03203 = 0.02915 0.00481 0.01020 -0.00259 AFIX 43 H33 2 1.009900 0.715334 1.027679 11.00000 -1.20000 AFIX 0 C10 1 0.873636 0.941770 0.862943 11.00000 0.02611 0.06976 = 0.02050 -0.01383 -0.00233 0.01805 AFIX 13 H10 2 0.955968 0.934584 0.849401 11.00000 -1.20000 AFIX 0 C26 1 0.574169 0.269852 1.214262 11.00000 0.04351 0.05943 = 0.03235 0.00381 0.01513 -0.01848 AFIX 43 H26 2 0.527708 0.204363 1.223683 11.00000 -1.20000 AFIX 0 C32 1 0.757698 0.585737 1.019887 11.00000 0.05273 0.05308 = 0.03316 0.00898 -0.01040 0.01431 AFIX 43 H32 2 0.685792 0.584901 1.003067 11.00000 -1.20000 AFIX 0 C25 1 0.652939 0.254476 1.180639 11.00000 0.04785 0.03999 = 0.02950 -0.00430 0.01137 -0.01623 AFIX 43 H25 2 0.661636 0.179231 1.168057 11.00000 -1.20000 AFIX 0 C27 1 0.623141 0.461448 1.219274 11.00000 0.05896 0.04113 = 0.04971 -0.00421 0.02613 0.01109 AFIX 43 H27 2 0.613702 0.535540 1.232644 11.00000 -1.20000 AFIX 0 C16 1 0.787525 0.778146 0.914481 11.00000 0.04822 0.06213 = 0.03913 0.00367 0.00196 0.02853 C15 1 0.814250 0.819587 0.869573 11.00000 0.04949 0.04953 = 0.02398 0.00474 0.00768 0.02930 AFIX 13 H15 2 0.867422 0.759459 0.855697 11.00000 -1.20000 AFIX 0 C13 1 0.738132 0.832414 0.797942 11.00000 0.04692 0.04441 = 0.02431 -0.00183 -0.00215 0.00158 AFIX 43 H13 2 0.729884 0.769638 0.778461 11.00000 -1.20000 AFIX 0 PART 1 O9 4 0.863276 0.343817 0.861776 21.00000 0.14830 0.17397 = 0.14706 -0.01022 0.01880 0.04883 C41 1 0.794999 0.355715 0.899461 21.00000 0.11288 0.08202 = 0.13189 0.02775 0.01192 -0.00763 AFIX 23 H41A 2 0.850312 0.373030 0.923334 21.00000 -1.20000 H41B 2 0.750125 0.282115 0.905631 21.00000 -1.20000 AFIX 0 C42 1 0.705331 0.456588 0.892912 21.00000 0.10449 0.04612 = 0.09909 -0.00984 0.01288 -0.02481 AFIX 23 H42A 2 0.619197 0.429378 0.893276 21.00000 -1.20000 H42B 2 0.716521 0.519512 0.914056 21.00000 -1.20000 AFIX 0 C43 1 0.744963 0.495637 0.849369 21.00000 0.05989 0.06652 = 0.10012 -0.01478 -0.00197 -0.01240 AFIX 23 H43A 2 0.672281 0.517858 0.832538 21.00000 -1.20000 H43B 2 0.799229 0.565064 0.851565 21.00000 -1.20000 AFIX 0 C44 1 0.806588 0.404351 0.829938 21.00000 0.13296 0.08266 = 0.10306 -0.00682 0.03296 0.01141 AFIX 23 H44A 2 0.748577 0.352826 0.814690 21.00000 -1.20000 H44B 2 0.867678 0.435051 0.809727 21.00000 -1.20000 AFIX 0 SAME 0.002 0.002 O9 > C44 PART 0 PART 2 O9' 4 0.791853 0.310502 0.856712 -21.00000 0.40103 0.35088 = 0.17790 -0.15678 -0.13964 0.25808 C41' 1 0.824091 0.320915 0.899746 -21.00000 0.13881 0.20501 = 0.16212 -0.07796 -0.05195 0.04287 AFIX 23 H41C 2 0.914229 0.318431 0.903063 -21.00000 -1.20000 H41D 2 0.787975 0.255602 0.916148 -21.00000 -1.20000 AFIX 0 C42' 1 0.774100 0.438279 0.915076 -21.00000 0.03926 0.14879 = 0.12509 -0.05915 0.00799 -0.02035 AFIX 23 H42C 2 0.716242 0.428405 0.938781 -21.00000 -1.20000 H42D 2 0.840490 0.492828 0.923362 -21.00000 -1.20000 AFIX 0 C43' 1 0.709627 0.478365 0.875328 -21.00000 0.44841 0.30568 = 0.17141 -0.13351 -0.12895 0.23422 AFIX 23 H43C 2 0.620705 0.462454 0.877569 -21.00000 -1.20000 H43D 2 0.721179 0.563973 0.871481 -21.00000 -1.20000 AFIX 0 C44' 1 0.757933 0.418442 0.841307 -21.00000 0.68847 0.38810 = 0.15082 -0.12385 -0.09853 0.35095 AFIX 23 H44C 2 0.695852 0.409772 0.818832 -21.00000 -1.20000 H44D 2 0.829725 0.460647 0.829748 -21.00000 -1.20000 AFIX 0 HKLF 4 REM mcg18136_a.res in P2(1)2(1)2(1) REM R1 = 0.0591 for 5696 Fo > 4sig(Fo) and 0.0762 for all 6949 data REM 584 parameters refined using 83 restraints END WGHT 0.0920 2.7215 REM Highest difference peak 0.859, deepest hole -0.404, 1-sigma level 0.061 Q1 1 0.7798 0.9153 0.9411 11.00000 0.05 0.86 Q2 1 0.8298 1.1566 0.8932 11.00000 0.05 0.78 Q3 1 0.9062 1.0830 0.8860 11.00000 0.05 0.54 Q4 1 0.8446 0.8481 0.9202 11.00000 0.05 0.47 Q5 1 0.6124 0.5348 0.9098 11.00000 0.05 0.41 Q6 1 0.8547 0.5407 0.8743 11.00000 0.05 0.33 Q7 1 0.6022 0.4648 0.8954 11.00000 0.05 0.29 Q8 1 0.6953 0.5407 0.8275 11.00000 0.05 0.29 Q9 1 0.7152 0.5276 0.8218 11.00000 0.05 0.29 Q10 1 0.9524 0.8352 0.9346 11.00000 0.05 0.27 Q11 1 0.6228 0.3646 0.8770 11.00000 0.05 0.24 Q12 1 0.6004 1.1186 0.8955 11.00000 0.05 0.24 Q13 1 0.7211 0.4406 0.8641 11.00000 0.05 0.24 Q14 1 0.8925 1.0075 0.8455 11.00000 0.05 0.23 Q15 1 0.8685 0.8635 0.9528 11.00000 0.05 0.22 Q16 1 0.8007 0.3864 0.8379 11.00000 0.05 0.21 Q17 1 0.8825 0.4238 0.8415 11.00000 0.05 0.21 Q18 1 0.6858 1.0448 0.8883 11.00000 0.05 0.20 Q19 1 0.9982 0.1536 1.1795 11.00000 0.05 0.20 Q20 1 0.6951 0.4188 0.8973 11.00000 0.05 0.19 ; _shelx_res_checksum 77484 _olex2_submission_special_instructions 'No special instructions were received' # start Validation Reply Form _vrf_PLAT260_mcg18136d ; PROBLEM: Large Average Ueq of Residue Including O9' 0.261 Check RESPONSE: Large Average Ueq of Residue Is Due To The Disordered Solvent Molecule ; _vrf_PLAT097_mcg18136d ; PROBLEM: Large Reported Max. (Positive) Residual Density 0.86 eA-3 RESPONSE:90% Of The Most Disagreeable Reflections Have Fo^2>Fc^2 Indicates Undetected Non-Merohedral Twin ; # end Validation Reply Form ####################################################################### # # This file contains crystal structure data downloaded from the # Cambridge Structural Database (CSD) hosted by the Cambridge # Crystallographic Data Centre (CCDC). # # Full information about CCDC data access policies and citation # guidelines are available at http://www.ccdc.cam.ac.uk/access/V1 # # Audit and citation data items may have been added by the CCDC. # Please retain this information to preserve the provenance of # this file and to allow appropriate attribution of the data. # ####################################################################### data_dalecorrectedmcg1797a_a _database_code_depnum_ccdc_archive 'CCDC 1876029' loop_ _audit_author_name _audit_author_address 'Dale C. Swenson' 'University of Iowa' _audit_update_record ; 2019-03-04 deposited with the CCDC. 2020-03-09 downloaded from the CCDC. ; _audit_creation_date 2018-10-22 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _shelx_SHELXL_version_number 2014/7 _chemical_name_common ? _chemical_name_systematic 'exo,exo-7-oxa-5-norbornene-2,3-dicarboxylic acid' _chemical_formula_moiety 'C8 H8 O5' _chemical_formula_sum 'C8 H8 O5' _chemical_formula_weight 184.14 _chemical_absolute_configuration unk _chemical_melting_point ? loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _space_group_crystal_system monoclinic _space_group_IT_number 4 _space_group_name_H-M_alt 'P 1 21 1' _space_group_name_Hall 'P 2yb' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, y+1/2, -z' _cell_length_a 9.2321(19) _cell_length_b 18.768(4) _cell_length_c 18.876(4) _cell_angle_alpha 90 _cell_angle_beta 93.72(3) _cell_angle_gamma 90 _cell_volume 3263.8(11) _cell_formula_units_Z 16 _cell_measurement_reflns_used 6898 _cell_measurement_temperature 190(2) _cell_measurement_theta_max 48.97 _cell_measurement_theta_min 6.128 _shelx_estimated_absorpt_T_max 0.984 _shelx_estimated_absorpt_T_min 0.965 _exptl_absorpt_coefficient_mu 0.127 _exptl_absorpt_correction_T_max 0.7253 _exptl_absorpt_correction_T_min 0.6778 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; SADABS-2014/5 (Bruker,2014/5) was used for absorption correction. wR2(int) was 0.0696 before and 0.0639 after correction. The Ratio of minimum to maximum transmission is 0.9345. The \l/2 correction factor is 0.00150. ; _exptl_absorpt_special_details ? _exptl_crystal_colour colourless _exptl_crystal_colour_primary colourless _exptl_crystal_density_diffrn 1.499 _exptl_crystal_density_meas ? _exptl_crystal_density_method ? _exptl_crystal_description prism _exptl_crystal_F_000 1536 _exptl_crystal_preparation ? _exptl_crystal_recrystallization_method 'slow evaporation from ethyl acetate' _exptl_crystal_size_max 0.28 _exptl_crystal_size_mid 0.19 _exptl_crystal_size_min 0.13 _exptl_transmission_factor_max ? _exptl_transmission_factor_min ? _diffrn_reflns_av_R_equivalents 0.0553 _diffrn_reflns_av_unetI/netI 0.0725 _diffrn_reflns_Laue_measured_fraction_full 0.999 _diffrn_reflns_Laue_measured_fraction_max 0.993 _diffrn_reflns_limit_h_max 11 _diffrn_reflns_limit_h_min -11 _diffrn_reflns_limit_k_max 23 _diffrn_reflns_limit_k_min -23 _diffrn_reflns_limit_l_max 20 _diffrn_reflns_limit_l_min -23 _diffrn_reflns_number 50626 _diffrn_reflns_point_group_measured_fraction_full 0.950 _diffrn_reflns_point_group_measured_fraction_max 0.928 _diffrn_reflns_theta_full 25.242 _diffrn_reflns_theta_max 26.432 _diffrn_reflns_theta_min 2.162 _diffrn_ambient_temperature 190.15 _diffrn_detector_area_resol_mean ? _diffrn_measured_fraction_theta_full 0.999 _diffrn_measured_fraction_theta_max 0.993 _diffrn_measurement_device_type 'Nonius APEX II Kappa' _diffrn_measurement_method ? _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_source ? _reflns_Friedel_coverage 0.811 _reflns_Friedel_fraction_full 0.897 _reflns_Friedel_fraction_max 0.859 _reflns_number_gt 7838 _reflns_number_total 12483 _reflns_special_details ; Reflections were merged by SHELXL according to the crystal class for the calculation of statistics and refinement. _reflns_Friedel_fraction is defined as the number of unique Friedel pairs measured divided by the number that would be possible theoretically, ignoring centric projections and systematic absences. ; _reflns_threshold_expression 'I > 2\s(I)' _computing_cell_refinement ? _computing_data_collection ? _computing_data_reduction ? _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution ? _refine_diff_density_max 0.328 _refine_diff_density_min -0.292 _refine_diff_density_rms 0.057 _refine_ls_abs_structure_details ; Flack x determined using 2575 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259). ; _refine_ls_abs_structure_Flack -0.5(9) _refine_ls_extinction_coef . _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.023 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 1156 _refine_ls_number_reflns 12483 _refine_ls_number_restraints 1296 _refine_ls_R_factor_all 0.1096 _refine_ls_R_factor_gt 0.0584 _refine_ls_restrained_S_all 1.000 _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0672P)^2^+1.6901P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1352 _refine_ls_wR_factor_ref 0.1632 _refine_special_details 'All nonhydrogen atoms were identified from the difference Fourier map within several refinement steps. Hydrogen atoms associated with carbon atoms were refined in geometrically constrained positions with isotropic thermal parameter. some reflections were omitted due to beamstop shadowing.' _olex2_refinement_description ; 1. Fixed Uiso At 1 times of: All O(O,O) groups At 1.2 times of: All C(H) groups At 1.5 times of: All O(H) groups, All O(H,H) groups 2. Restrained distances C6-C8 \\sim C6'-C8 \\sim C7-C9 \\sim C7'-C9 with sigma of 0.01 C16-C18 \\sim C16'-C18 \\sim C17-C19 \\sim C17'-C19 with sigma of 0.01 C26-C28 \\sim C26'-C28 \\sim C27-C29 \\sim C27'-C29 with sigma of 0.02 C36-C38 \\sim C36'-C38 \\sim C37-C39 \\sim C37'-C39 with sigma of 0.01 C69-O69A \\sim C69-O69C with sigma of 0.01 C69-O69B \\sim C69-O69D with sigma of 0.01 O69A-O69B \\sim O69C-O69D with sigma of 0.01 C78-O78A \\sim C78-O78C with sigma of 0.01 C78-O78B \\sim C78-O78B with sigma of 0.01 O78A-O78B \\sim O78C-O78D with sigma of 0.01 3. Restrained planarity C67, C69, O69C, O69D with sigma of 0.1 C76, C78, O78C, O78D with sigma of 0.1 4. Uiso/Uaniso restraints and constraints Uanis(C6) = Uanis(C6') Uanis(C7) = Uanis(C7') Uanis(C16) = Uanis(C16') Uanis(C17) = Uanis(C17') Uanis(C27) = Uanis(C26') Uanis(C27) = Uanis(C27') Uanis(C36) = Uanis(C36') Uanis(C37) = Uanis(C37') 5. Rigid body (RIGU) restrains All non-hydrogen atoms with sigma for 1-2 distances of 0.004 and sigma for 1-3 distances of 0.004 6. Same fragment restrains {O1, C2, C3, C4, C5, C6, C7} sigma for 1-2: 0.02, 1-3: 0.04 as {O1', C2', C3', C4', C5', C6', C7'} {O11, C12, C13, C14, C15, C16, C17} sigma for 1-2: 0.02, 1-3: 0.04 as {O11', C12', C13', C14', C15', C16', C17'} {O21, C22, C23, C24, C25, C26, C27} sigma for 1-2: 0.02, 1-3: 0.04 as {O21', C22', C23', C24', C25', C26', C27'} {O31, C32, C33, C34, C35, C36, C37} sigma for 1-2: 0.02, 1-3: 0.04 as {O31', C32', C33', C34', C35', C36', C37'} 7. Others Sof(O1')=Sof(C2')=Sof(H2')=Sof(C3')=Sof(H3')=Sof(C4')=Sof(H4')=Sof(C5')= Sof(H5')=Sof(C6')=Sof(H6')=Sof(C7')=Sof(H7')=Sof(O21')=Sof(C22')=Sof(H22')= Sof(C23')=Sof(H23')=Sof(C24')=Sof(H24')=Sof(C25')=Sof(H25')=Sof(C26')= Sof(H26')=Sof(C27')=Sof(H27')=1-FVAR(1) Sof(O1)=Sof(C2)=Sof(H2)=Sof(C3)=Sof(H3)=Sof(C4)=Sof(H4)=Sof(C5)=Sof(H5)= Sof(C6)=Sof(H6)=Sof(C7)=Sof(H7)=Sof(O21)=Sof(C22)=Sof(H22)=Sof(C23)=Sof(H23)= Sof(C24)=Sof(H24)=Sof(C25)=Sof(H25)=Sof(C26)=Sof(H26)=Sof(C27)=Sof(H27)=FVAR(1) Sof(O11')=Sof(C12')=Sof(H12')=Sof(C13')=Sof(H13')=Sof(C14')=Sof(H14')= Sof(C15')=Sof(H15')=Sof(C16')=Sof(H16')=Sof(C17')=Sof(H17')=Sof(O31')= Sof(C32')=Sof(H32')=Sof(C33')=Sof(H33')=Sof(C34')=Sof(H34')=Sof(C35')= Sof(H35')=Sof(C36')=Sof(H36')=Sof(C37')=Sof(H37')=1-FVAR(2) Sof(O11)=Sof(C12)=Sof(H12)=Sof(C13)=Sof(H13)=Sof(C14)=Sof(H14)=Sof(C15)= Sof(H15)=Sof(C16)=Sof(H16)=Sof(C17)=Sof(H17)=Sof(O31)=Sof(C32)=Sof(H32)= Sof(C33)=Sof(H33)=Sof(C34)=Sof(H34)=Sof(C35)=Sof(H35)=Sof(C36)=Sof(H36)= Sof(C37)=Sof(H37)=FVAR(2) Sof(O69C)=Sof(H69C)=Sof(O69D)=Sof(O78C)=Sof(H78C)=Sof(O78D)=1-FVAR(3) Sof(O69B)=Sof(O69A)=Sof(H69A)=Sof(O78B)=Sof(O78A)=Sof(H78A)=FVAR(3) 8.a Ternary CH refined with riding coordinates: C2(H2), C5(H5), C6(H6), C7(H7), C2'(H2'), C5'(H5'), C6'(H6'), C7'(H7'), C12(H12), C15(H15), C16(H16), C17(H17), C12'(H12'), C15'(H15'), C16'(H16'), C17'(H17'), C22(H22), C25(H25), C26(H26), C27(H27), C22'(H22'), C25'(H25'), C26'(H26'), C27'(H27'), C32(H32), C35(H35), C36(H36), C37(H37), C32'(H32'), C35'(H35'), C36'(H36'), C37'(H37'), C42(H42), C45(H45), C46(H46), C47(H47), C52(H52), C55(H55), C56(H56), C57(H57), C62(H62), C65(H65), C66(H66), C67(H67), C72(H72), C75(H75), C76(H76), C77(H77) 8.b Aromatic/amide H refined with riding coordinates: C3(H3), C4(H4), C3'(H3'), C4'(H4'), C13(H13), C14(H14), C13'(H13'), C14'(H14'), C23(H23), C24(H24), C23'(H23'), C24'(H24'), C33(H33), C34(H34), C33'(H33'), C34'(H34'), C43(H43), C44(H44), C53(H53), C54(H54), C63(H63), C64(H64), C73(H73), C74(H74) 8.c Tetrahedral OH refined with riding coordinates: O8A(H8A), O9A(H9A), O18A(H18A), O19A(H19A), O28A(H28A), O29A(H29A), O38A(H38A), O39A(H39A), O48A(H48A), O49A(H49A), O58A(H58A), O59A(H59A), O68A(H68A), O69A(H69A), O69C(H69C), O78A(H78A), O78C(H78C), O79A(H79A) ; _atom_sites_solution_hydrogens geom _atom_sites_solution_primary ? _atom_sites_solution_secondary ? loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group O1 O 0.0249(5) 0.6837(3) 0.4009(3) 0.0237(12) Uani 0.825(3) 1 d D U P A 1 C2 C 0.1259(8) 0.7120(4) 0.4528(4) 0.0195(15) Uani 0.825(3) 1 d D U P A 1 H2 H 0.0938 0.7113 0.5024 0.023 Uiso 0.825(3) 1 calc R . P A 1 C3 C 0.1558(8) 0.7856(4) 0.4240(4) 0.0175(15) Uani 0.825(3) 1 d D U P A 1 H3 H 0.1789 0.8276 0.4505 0.021 Uiso 0.825(3) 1 calc R . P A 1 C4 C 0.1430(8) 0.7789(4) 0.3542(4) 0.0224(17) Uani 0.825(3) 1 d D U P A 1 H4 H 0.1554 0.8149 0.3198 0.027 Uiso 0.825(3) 1 calc R . P A 1 C5 C 0.1044(8) 0.7014(4) 0.3410(4) 0.0238(16) Uani 0.825(3) 1 d D U P A 1 H5 H 0.0536 0.6910 0.2937 0.029 Uiso 0.825(3) 1 calc R . P A 1 C6 C 0.2550(12) 0.6600(4) 0.3572(5) 0.0231(17) Uani 0.825(3) 1 d D U P A 1 H6 H 0.3369 0.6887 0.3399 0.028 Uiso 0.825(3) 1 calc R . P A 1 C7 C 0.2557(12) 0.6648(4) 0.4404(5) 0.0198(18) Uani 0.825(3) 1 d D U P A 1 H7 H 0.3455 0.6908 0.4580 0.024 Uiso 0.825(3) 1 calc R . P A 1 O1' O 0.472(2) 0.6925(13) 0.3821(14) 0.042(6) Uani 0.175(3) 1 d D U P A 2 C2' C 0.396(3) 0.7177(15) 0.4376(15) 0.038(6) Uani 0.175(3) 1 d D U P A 2 H2' H 0.4538 0.7206 0.4840 0.045 Uiso 0.175(3) 1 calc R . P A 2 C3' C 0.336(5) 0.7890(16) 0.4101(19) 0.057(9) Uani 0.175(3) 1 d D U P A 2 H3' H 0.3163 0.8299 0.4376 0.068 Uiso 0.175(3) 1 calc R . P A 2 C4' C 0.316(5) 0.7825(16) 0.3396(19) 0.051(8) Uani 0.175(3) 1 d D U P A 2 H4' H 0.2797 0.8168 0.3060 0.061 Uiso 0.175(3) 1 calc R . P A 2 C5' C 0.367(3) 0.7074(16) 0.3263(15) 0.040(6) Uani 0.175(3) 1 d D U P A 2 H5' H 0.3962 0.6973 0.2773 0.048 Uiso 0.175(3) 1 calc R . P A 2 C6' C 0.234(5) 0.6608(11) 0.352(2) 0.0231(17) Uani 0.175(3) 1 d D U P A 2 H6' H 0.1362 0.6816 0.3390 0.028 Uiso 0.175(3) 1 calc R . P A 2 C7' C 0.277(6) 0.6605(16) 0.435(2) 0.0198(18) Uani 0.175(3) 1 d D U P A 2 H7' H 0.1954 0.6902 0.4506 0.024 Uiso 0.175(3) 1 calc R . P A 2 C8 C 0.2542(7) 0.5873(4) 0.3248(4) 0.0281(16) Uani 1 1 d D U . . . O8A O 0.1508(5) 0.5440(3) 0.3381(3) 0.0323(12) Uani 1 1 d . U . . . H8A H 0.1617 0.5055 0.3163 0.048 Uiso 1 1 calc R . . . . O8B O 0.3529(5) 0.5705(3) 0.2864(3) 0.0407(14) Uani 1 1 d . U . . . C9 C 0.2529(7) 0.5955(3) 0.4777(4) 0.0235(14) Uani 1 1 d D U . . . O9A O 0.3608(5) 0.5525(3) 0.4640(3) 0.0327(13) Uani 1 1 d . U . . . H9A H 0.3529 0.5142 0.4864 0.049 Uiso 1 1 calc R . . . . O9B O 0.1616(5) 0.5803(3) 0.5200(3) 0.0348(13) Uani 1 1 d . U . . . O11 O 0.0449(5) 0.3171(3) 0.1408(3) 0.0392(15) Uani 0.854(3) 1 d D U P B 1 C12 C 0.1415(8) 0.2901(4) 0.1979(4) 0.0284(17) Uani 0.854(3) 1 d D U P B 1 H12 H 0.1005 0.2909 0.2456 0.034 Uiso 0.854(3) 1 calc R . P B 1 C13 C 0.1786(8) 0.2163(4) 0.1716(4) 0.0248(17) Uani 0.854(3) 1 d D U P B 1 H13 H 0.1981 0.1746 0.1991 0.030 Uiso 0.854(3) 1 calc R . P B 1 C14 C 0.1776(9) 0.2227(4) 0.1028(4) 0.032(2) Uani 0.854(3) 1 d D U P B 1 H14 H 0.1973 0.1865 0.0696 0.039 Uiso 0.854(3) 1 calc R . P B 1 C15 C 0.1387(9) 0.2996(4) 0.0864(4) 0.0323(18) Uani 0.854(3) 1 d D U P B 1 H15 H 0.0979 0.3087 0.0369 0.039 Uiso 0.854(3) 1 calc R . P B 1 C16 C 0.2781(8) 0.3432(3) 0.1095(4) 0.0190(15) Uani 0.854(3) 1 d D U P B 1 H16 H 0.3660 0.3185 0.0933 0.023 Uiso 0.854(3) 1 calc R . P B 1 C17 C 0.2732(8) 0.3362(4) 0.1918(4) 0.0208(16) Uani 0.854(3) 1 d D U P B 1 H17 H 0.3616 0.3105 0.2117 0.025 Uiso 0.854(3) 1 calc R . P B 1 O11' O 0.448(3) 0.3267(17) 0.1347(17) 0.047(7) Uani 0.146(3) 1 d D U P B 2 C12' C 0.358(4) 0.2960(18) 0.1863(16) 0.040(6) Uani 0.146(3) 1 d D U P B 2 H12' H 0.4038 0.2929 0.2357 0.048 Uiso 0.146(3) 1 calc R . P B 2 C13' C 0.308(5) 0.2254(17) 0.154(2) 0.049(9) Uani 0.146(3) 1 d D U P B 2 H13' H 0.2645 0.1873 0.1779 0.058 Uiso 0.146(3) 1 calc R . P B 2 C14' C 0.335(6) 0.2266(18) 0.088(2) 0.054(9) Uani 0.146(3) 1 d D U P B 2 H14' H 0.3381 0.1879 0.0556 0.065 Uiso 0.146(3) 1 calc R . P B 2 C15' C 0.360(4) 0.3052(19) 0.0740(17) 0.044(6) Uani 0.146(3) 1 d D U P B 2 H15' H 0.3953 0.3179 0.0267 0.052 Uiso 0.146(3) 1 calc R . P B 2 C16' C 0.215(3) 0.3416(9) 0.0939(17) 0.0190(15) Uani 0.146(3) 1 d D U P B 2 H16' H 0.1213 0.3234 0.0712 0.023 Uiso 0.146(3) 1 calc R . P B 2 C17' C 0.232(4) 0.3461(15) 0.1770(16) 0.0208(16) Uani 0.146(3) 1 d D U P B 2 H17' H 0.1472 0.3198 0.1944 0.025 Uiso 0.146(3) 1 calc R . P B 2 C18 C 0.2634(8) 0.4166(4) 0.0754(4) 0.0290(16) Uani 1 1 d D U . . . O18B O 0.1654(6) 0.4599(3) 0.0881(3) 0.0442(15) Uani 1 1 d . U . . . O18A O 0.3541(7) 0.4291(4) 0.0304(4) 0.080(3) Uani 1 1 d . U . . . H18A H 0.3365 0.4690 0.0116 0.120 Uiso 1 1 calc R . . . . C19 C 0.2608(8) 0.4079(4) 0.2288(4) 0.0266(15) Uani 1 1 d D U . . . O19B O 0.1618(5) 0.4198(3) 0.2687(3) 0.0321(12) Uani 1 1 d . U . . . O19A O 0.3664(5) 0.4503(3) 0.2195(3) 0.0389(13) Uani 1 1 d . U . . . H19A H 0.3488 0.4903 0.2370 0.058 Uiso 1 1 calc R . . . . O21 O 0.5302(6) 0.8082(3) 0.3653(3) 0.0323(14) Uani 0.825(3) 1 d D U P A 1 C22 C 0.6233(9) 0.7815(4) 0.3127(4) 0.0305(18) Uani 0.825(3) 1 d D U P A 1 H22 H 0.5793 0.7822 0.2629 0.037 Uiso 0.825(3) 1 calc R . P A 1 C23 C 0.6625(9) 0.7075(4) 0.3413(4) 0.0305(19) Uani 0.825(3) 1 d D U P A 1 H23 H 0.6808 0.6657 0.3149 0.037 Uiso 0.825(3) 1 calc R . P A 1 C24 C 0.6651(9) 0.7146(4) 0.4101(4) 0.0294(18) Uani 0.825(3) 1 d D U P A 1 H24 H 0.6866 0.6783 0.4443 0.035 Uiso 0.825(3) 1 calc R . P A 1 C25 C 0.6278(9) 0.7908(4) 0.4252(4) 0.0267(17) Uani 0.825(3) 1 d D U P A 1 H25 H 0.5896 0.7998 0.4728 0.032 Uiso 0.825(3) 1 calc R . P A 1 C26 C 0.7630(12) 0.8354(4) 0.4084(5) 0.025(2) Uani 0.825(3) 1 d D U P A 1 H26 H 0.8523 0.8131 0.4316 0.030 Uiso 0.825(3) 1 calc R . P A 1 C27 C 0.7661(9) 0.8285(4) 0.3256(4) 0.0226(17) Uani 0.825(3) 1 d D U P A 1 H27 H 0.8528 0.8001 0.3135 0.027 Uiso 0.825(3) 1 calc R . P A 1 O21' O 0.974(3) 0.8238(16) 0.3530(17) 0.057(7) Uani 0.175(3) 1 d D U P A 2 C22' C 0.877(3) 0.7911(18) 0.2972(16) 0.047(6) Uani 0.175(3) 1 d D U P A 2 H22' H 0.9075 0.7951 0.2475 0.057 Uiso 0.175(3) 1 calc R . P A 2 C23' C 0.856(5) 0.7153(16) 0.326(2) 0.054(9) Uani 0.175(3) 1 d D U P A 2 H23' H 0.8404 0.6723 0.2997 0.065 Uiso 0.175(3) 1 calc R . P A 2 C24' C 0.866(5) 0.7248(17) 0.393(2) 0.061(9) Uani 0.175(3) 1 d D U P A 2 H24' H 0.8597 0.6884 0.4280 0.074 Uiso 0.175(3) 1 calc R . P A 2 C25' C 0.890(4) 0.8033(18) 0.4092(17) 0.049(6) Uani 0.175(3) 1 d D U P A 2 H25' H 0.9368 0.8134 0.4575 0.058 Uiso 0.175(3) 1 calc R . P A 2 C26' C 0.747(5) 0.8432(17) 0.392(2) 0.0226(17) Uani 0.175(3) 1 d D U P A 2 H26' H 0.6728 0.8133 0.4143 0.027 Uiso 0.175(3) 1 calc R . P A 2 C27' C 0.728(4) 0.8252(13) 0.3120(18) 0.0226(17) Uani 0.175(3) 1 d D U P A 2 H27' H 0.6380 0.7996 0.2945 0.027 Uiso 0.175(3) 1 calc R . P A 2 C28 C 0.7498(7) 0.9111(4) 0.4339(4) 0.0250(15) Uani 1 1 d D U . . . O28B O 0.6534(6) 0.9292(3) 0.4721(3) 0.0473(16) Uani 1 1 d . U . . . O28A O 0.8564(5) 0.9530(3) 0.4186(3) 0.0332(13) Uani 1 1 d . U . . . H28A H 0.8479 0.9924 0.4390 0.050 Uiso 1 1 calc R . . . . C29 C 0.7566(7) 0.8959(4) 0.2816(4) 0.0294(16) Uani 1 1 d D U . . . O29B O 0.8506(5) 0.9089(3) 0.2400(3) 0.0352(13) Uani 1 1 d . U . . . O29A O 0.6483(5) 0.9375(3) 0.2902(3) 0.0355(13) Uani 1 1 d . U . . . H29A H 0.6628 0.9770 0.2710 0.053 Uiso 1 1 calc R . . . . O31 O 0.4477(6) 0.6846(3) 0.8888(3) 0.0396(14) Uani 0.854(3) 1 d D U P B 1 C32 C 0.3537(9) 0.7101(4) 0.9396(4) 0.0354(19) Uani 0.854(3) 1 d D U P B 1 H32 H 0.3949 0.7102 0.9899 0.042 Uiso 0.854(3) 1 calc R . P B 1 C33 C 0.3073(10) 0.7818(4) 0.9099(4) 0.035(2) Uani 0.854(3) 1 d D U P B 1 H33 H 0.2828 0.8229 0.9359 0.042 Uiso 0.854(3) 1 calc R . P B 1 C34 C 0.3079(9) 0.7752(4) 0.8399(4) 0.0296(18) Uani 0.854(3) 1 d D U P B 1 H34 H 0.2845 0.8107 0.8051 0.036 Uiso 0.854(3) 1 calc R . P B 1 C35 C 0.3543(9) 0.6985(4) 0.8273(4) 0.0326(18) Uani 0.854(3) 1 d D U P B 1 H35 H 0.3988 0.6901 0.7811 0.039 Uiso 0.854(3) 1 calc R . P B 1 C36 C 0.2240(14) 0.6505(4) 0.8406(5) 0.0312(18) Uani 0.854(3) 1 d D U P B 1 H36 H 0.1348 0.6719 0.8163 0.037 Uiso 0.854(3) 1 calc R . P B 1 C37 C 0.2149(8) 0.6587(4) 0.9231(4) 0.0293(18) Uani 0.854(3) 1 d D U P B 1 H37 H 0.1233 0.6835 0.9342 0.035 Uiso 0.854(3) 1 calc R . P B 1 O31' O 0.034(3) 0.6880(17) 0.8958(18) 0.050(7) Uani 0.146(3) 1 d D U P B 2 C32' C 0.138(4) 0.7136(19) 0.9482(17) 0.041(6) Uani 0.146(3) 1 d D U P B 2 H32' H 0.1073 0.7123 0.9980 0.049 Uiso 0.146(3) 1 calc R . P B 2 C33' C 0.167(5) 0.7861(17) 0.9198(19) 0.040(9) Uani 0.146(3) 1 d D U P B 2 H33' H 0.1773 0.8298 0.9451 0.047 Uiso 0.146(3) 1 calc R . P B 2 C34' C 0.176(6) 0.7747(19) 0.8498(19) 0.050(10) Uani 0.146(3) 1 d D U P B 2 H34' H 0.2150 0.8059 0.8162 0.060 Uiso 0.146(3) 1 calc R . P B 2 C35' C 0.110(4) 0.701(2) 0.8357(17) 0.047(7) Uani 0.146(3) 1 d D U P B 2 H35' H 0.0533 0.6955 0.7892 0.056 Uiso 0.146(3) 1 calc R . P B 2 C36' C 0.237(7) 0.6474(15) 0.850(3) 0.0312(18) Uani 0.146(3) 1 d D U P B 2 H36' H 0.3193 0.6727 0.8289 0.037 Uiso 0.146(3) 1 calc R . P B 2 C37' C 0.268(4) 0.6617(13) 0.932(2) 0.0293(18) Uani 0.146(3) 1 d D U P B 2 H37' H 0.3667 0.6816 0.9447 0.035 Uiso 0.146(3) 1 calc R . P B 2 C38 C 0.2403(8) 0.5762(4) 0.8144(4) 0.0358(18) Uani 1 1 d D U . . . O38B O 0.3422(6) 0.5585(3) 0.7793(3) 0.0472(15) Uani 1 1 d . U . . . O38A O 0.1370(5) 0.5332(3) 0.8285(3) 0.0471(15) Uani 1 1 d . U . . . H38A H 0.1544 0.4925 0.8125 0.071 Uiso 1 1 calc R . . . . C39 C 0.2368(7) 0.5930(4) 0.9676(4) 0.0304(16) Uani 1 1 d D U . . . O39B O 0.3371(6) 0.5487(3) 0.9566(3) 0.0557(18) Uani 1 1 d . U . . . O39A O 0.1497(5) 0.5825(3) 1.0160(3) 0.0459(15) Uani 1 1 d . U . . . H39A H 0.1664 0.5425 1.0348 0.069 Uiso 1 1 calc R . . . . O41 O 0.2185(5) 0.9350(3) 0.5223(3) 0.0331(12) Uani 1 1 d . U . . . C42 C 0.1167(8) 0.9603(4) 0.5697(4) 0.0259(16) Uani 1 1 d . U . . . H42 H 0.0129 0.9588 0.5510 0.031 Uiso 1 1 calc R . . . . C43 C 0.1761(7) 1.0348(4) 0.5876(4) 0.0243(16) Uani 1 1 d . U . . . H43 H 0.1219 1.0757 0.5992 0.029 Uiso 1 1 calc R . . . . C44 C 0.3161(8) 1.0304(4) 0.5836(4) 0.0296(17) Uani 1 1 d . U . . . H44 H 0.3855 1.0676 0.5908 0.035 Uiso 1 1 calc R . . . . C45 C 0.3446(8) 0.9530(4) 0.5649(4) 0.0297(17) Uani 1 1 d . U . . . H45 H 0.4381 0.9442 0.5424 0.036 Uiso 1 1 calc R . . . . C46 C 0.3236(7) 0.9089(4) 0.6344(4) 0.0227(15) Uani 1 1 d . U . . . H46 H 0.3688 0.9349 0.6765 0.027 Uiso 1 1 calc R . . . . C47 C 0.1547(7) 0.9125(4) 0.6351(4) 0.0200(14) Uani 1 1 d . U . . . H47 H 0.1275 0.9376 0.6790 0.024 Uiso 1 1 calc R . . . . C48 C 0.3902(7) 0.8360(4) 0.6299(4) 0.0229(15) Uani 1 1 d . U . . . O48A O 0.3507(5) 0.7958(3) 0.5790(3) 0.0405(14) Uani 1 1 d . U . . . H48A H 0.4021 0.7588 0.5805 0.061 Uiso 1 1 calc R . . . . O48B O 0.4864(6) 0.8186(3) 0.6763(3) 0.0519(15) Uani 1 1 d . U . . . C49 C 0.0790(7) 0.8422(4) 0.6297(4) 0.0251(16) Uani 1 1 d . U . . . O49A O 0.1212(5) 0.7966(3) 0.6793(3) 0.0356(13) Uani 1 1 d . U . . . H49A H 0.0812 0.7570 0.6707 0.053 Uiso 1 1 calc R . . . . O49B O -0.0178(5) 0.8292(3) 0.5841(3) 0.0348(13) Uani 1 1 d . U . . . O51 O 0.7753(5) 0.5600(3) 0.7274(2) 0.0293(11) Uani 1 1 d . U . . . C52 C 0.8767(7) 0.5373(4) 0.6772(4) 0.0238(15) Uani 1 1 d . U . . . H52 H 0.9812 0.5407 0.6944 0.029 Uiso 1 1 calc R . . . . C53 C 0.8251(7) 0.4638(4) 0.6584(4) 0.0267(16) Uani 1 1 d . U . . . H53 H 0.8828 0.4245 0.6459 0.032 Uiso 1 1 calc R . . . . C54 C 0.6835(7) 0.4648(4) 0.6629(4) 0.0300(17) Uani 1 1 d . U . . . H54 H 0.6177 0.4263 0.6541 0.036 Uiso 1 1 calc R . . . . C55 C 0.6477(7) 0.5391(4) 0.6847(4) 0.0298(16) Uani 1 1 d . U . . . H55 H 0.5541 0.5444 0.7080 0.036 Uiso 1 1 calc R . . . . C56 C 0.6620(7) 0.5862(4) 0.6159(4) 0.0195(14) Uani 1 1 d . U . . . H56 H 0.6188 0.5599 0.5736 0.023 Uiso 1 1 calc R . . . . C57 C 0.8312(7) 0.5861(3) 0.6142(3) 0.0174(14) Uani 1 1 d . U . . . H57 H 0.8586 0.5629 0.5693 0.021 Uiso 1 1 calc R . . . . C58 C 0.5864(7) 0.6560(4) 0.6218(4) 0.0225(15) Uani 1 1 d . U . . . O58A O 0.6242(5) 0.6950(3) 0.6748(3) 0.0389(14) Uani 1 1 d . U . . . H58A H 0.5757 0.7329 0.6728 0.058 Uiso 1 1 calc R . . . . O58B O 0.4868(6) 0.6719(3) 0.5783(3) 0.0548(17) Uani 1 1 d . U . . . C59 C 0.9008(7) 0.6584(4) 0.6202(4) 0.0188(14) Uani 1 1 d . U . . . O59A O 0.8525(6) 0.7044(3) 0.5724(3) 0.0369(13) Uani 1 1 d . U . . . H59A H 0.8982 0.7429 0.5781 0.055 Uiso 1 1 calc R . . . . O59B O 0.9970(5) 0.6721(3) 0.6673(3) 0.0346(13) Uani 1 1 d . U . . . O61 O 0.7672(6) 0.4378(3) 0.9787(3) 0.0407(13) Uani 1 1 d . U . . . C62 C 0.6458(8) 0.4597(4) 0.9359(4) 0.0348(18) Uani 1 1 d . U . . . H62 H 0.5511 0.4547 0.9583 0.042 Uiso 1 1 calc R . . . . C63 C 0.6841(8) 0.5362(4) 0.9155(4) 0.0320(17) Uani 1 1 d . U . . . H63 H 0.6204 0.5754 0.9069 0.038 Uiso 1 1 calc R . . . . C64 C 0.8260(7) 0.5346(4) 0.9126(4) 0.0281(16) Uani 1 1 d . U . . . H64 H 0.8872 0.5731 0.9013 0.034 Uiso 1 1 calc R . . . . C65 C 0.8723(8) 0.4588(4) 0.9308(4) 0.0293(16) Uani 1 1 d . U . . . H65 H 0.9755 0.4535 0.9495 0.035 Uiso 1 1 calc R . . . . C66 C 0.8277(7) 0.4114(4) 0.8651(4) 0.0254(15) Uani 1 1 d . U . . . H66 H 0.8573 0.4356 0.8210 0.031 Uiso 1 1 calc R . . . . C67 C 0.6591(7) 0.4139(4) 0.8668(4) 0.0284(16) Uani 1 1 d . U . . . H67 H 0.6152 0.4397 0.8243 0.034 Uiso 1 1 calc R . . . . C68 C 0.8974(8) 0.3392(4) 0.8708(4) 0.0321(17) Uani 1 1 d . U . . . O68B O 0.9752(6) 0.3203(3) 0.9213(3) 0.0413(14) Uani 1 1 d . U . . . O68A O 0.8723(6) 0.3004(3) 0.8145(3) 0.0505(16) Uani 1 1 d . U . . . H68A H 0.9127 0.2606 0.8205 0.076 Uiso 1 1 calc R . . . . C69 C 0.5861(8) 0.3432(4) 0.8753(4) 0.0320(17) Uani 1 1 d D U . . . O69B O 0.6432(7) 0.2882(3) 0.9015(4) 0.047(2) Uani 0.840(9) 1 d D U P C 1 O69A O 0.4455(6) 0.3459(3) 0.8545(4) 0.044(2) Uani 0.840(9) 1 d D U P C 1 H69A H 0.4111 0.3044 0.8530 0.066 Uiso 0.840(9) 1 calc R . P C 1 O69C O 0.496(3) 0.322(2) 0.8211(12) 0.044 Uiso 0.160(9) 1 d DR U P C 2 H69C H 0.4898 0.2771 0.8215 0.066 Uiso 0.160(9) 1 calc R . P C 2 O69D O 0.613(4) 0.3041(18) 0.9278(12) 0.044 Uiso 0.160(9) 1 d DR U P C 2 O71 O 0.2102(5) 0.0638(3) 0.7698(2) 0.0320(12) Uani 1 1 d . U . . . C72 C 0.1084(8) 0.0374(4) 0.8185(4) 0.0269(16) Uani 1 1 d . U . . . H72 H 0.0040 0.0399 0.8008 0.032 Uiso 1 1 calc R . . . . C73 C 0.1640(7) -0.0364(4) 0.8352(4) 0.0295(17) Uani 1 1 d . U . . . H73 H 0.1087 -0.0771 0.8461 0.035 Uiso 1 1 calc R . . . . C74 C 0.3081(8) -0.0325(4) 0.8313(5) 0.0354(19) Uani 1 1 d . U . . . H74 H 0.3770 -0.0698 0.8390 0.042 Uiso 1 1 calc R . . . . C75 C 0.3367(8) 0.0433(4) 0.8123(4) 0.0363(18) Uani 1 1 d . U . . . H75 H 0.4304 0.0515 0.7898 0.044 Uiso 1 1 calc R . . . . C76 C 0.3178(7) 0.0880(4) 0.8820(4) 0.0234(15) Uani 1 1 d . U . . . H76 H 0.3642 0.0622 0.9239 0.028 Uiso 1 1 calc R . . . . C77 C 0.1505(7) 0.0850(4) 0.8843(3) 0.0212(14) Uani 1 1 d . U . . . H77 H 0.1250 0.0596 0.9284 0.025 Uiso 1 1 calc R . . . . C78 C 0.3870(8) 0.1592(4) 0.8753(4) 0.0319(17) Uani 1 1 d D U . . . O78B O 0.3275(7) 0.2121(4) 0.8486(4) 0.045(2) Uani 0.840(9) 1 d D U P C 1 O78A O 0.5267(6) 0.1570(3) 0.8948(4) 0.044(2) Uani 0.840(9) 1 d D U P C 1 H78A H 0.5639 0.1971 0.8885 0.066 Uiso 0.840(9) 1 calc R . P C 1 O78C O 0.470(3) 0.1794(18) 0.9314(12) 0.044 Uiso 0.160(9) 1 d DR U P C 2 H78C H 0.4965 0.2219 0.9262 0.066 Uiso 0.160(9) 1 calc R . P C 2 O78D O 0.366(4) 0.198(3) 0.8237(13) 0.044 Uiso 0.160(9) 1 d DR U P C 2 C79 C 0.0734(7) 0.1561(4) 0.8800(3) 0.0216(15) Uani 1 1 d . U . . . O79B O -0.0113(6) 0.1731(3) 0.8305(3) 0.0409(13) Uani 1 1 d . U . . . O79A O 0.0989(5) 0.1942(3) 0.9369(2) 0.0376(13) Uani 1 1 d . U . . . H79A H 0.0597 0.2344 0.9311 0.056 Uiso 1 1 calc R . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 O1 0.014(2) 0.017(3) 0.041(3) -0.001(2) 0.003(2) -0.003(2) C2 0.023(4) 0.013(3) 0.023(3) 0.001(3) 0.006(3) 0.005(3) C3 0.021(4) 0.009(3) 0.022(3) -0.002(3) 0.002(3) 0.000(3) C4 0.033(4) 0.012(3) 0.022(3) 0.003(3) -0.003(3) 0.000(3) C5 0.030(4) 0.016(3) 0.024(3) -0.002(3) -0.011(3) 0.002(3) C6 0.019(4) 0.020(3) 0.031(3) 0.000(2) 0.005(3) -0.003(2) C7 0.013(4) 0.016(3) 0.031(3) -0.007(2) 0.009(3) -0.001(2) O1' 0.030(8) 0.032(12) 0.066(11) -0.006(8) 0.008(7) -0.010(7) C2' 0.031(11) 0.029(9) 0.054(11) -0.003(7) 0.005(8) -0.015(8) C3' 0.08(2) 0.035(10) 0.061(14) 0.000(8) 0.015(12) 0.000(10) C4' 0.057(19) 0.037(10) 0.059(14) -0.003(8) 0.014(12) 0.004(10) C5' 0.035(10) 0.032(10) 0.054(11) -0.005(7) 0.014(8) -0.008(8) C6' 0.019(4) 0.020(3) 0.031(3) 0.000(2) 0.005(3) -0.003(2) C7' 0.013(4) 0.016(3) 0.031(3) -0.007(2) 0.009(3) -0.001(2) C8 0.023(3) 0.027(3) 0.035(4) 0.000(3) 0.009(3) -0.004(3) O8A 0.029(3) 0.024(3) 0.045(3) -0.007(2) 0.010(2) -0.008(2) O8B 0.034(3) 0.038(3) 0.053(3) -0.020(3) 0.024(3) -0.013(2) C9 0.021(3) 0.018(3) 0.031(3) -0.006(3) 0.001(3) 0.000(2) O9A 0.029(3) 0.023(3) 0.048(3) 0.008(2) 0.015(2) 0.012(2) O9B 0.030(3) 0.039(3) 0.038(3) 0.013(2) 0.017(2) 0.012(2) O11 0.020(3) 0.018(3) 0.079(4) -0.005(3) -0.007(3) 0.000(2) C12 0.032(4) 0.018(3) 0.036(4) -0.008(3) 0.008(3) -0.005(3) C13 0.029(4) 0.016(3) 0.029(4) -0.003(3) -0.004(3) -0.005(3) C14 0.053(5) 0.017(3) 0.025(4) -0.005(3) -0.008(3) 0.000(3) C15 0.043(4) 0.020(4) 0.031(4) 0.002(3) -0.018(3) -0.003(3) C16 0.025(4) 0.015(3) 0.016(3) 0.004(2) 0.000(3) 0.007(3) C17 0.026(4) 0.019(3) 0.018(3) 0.006(2) -0.001(3) 0.004(3) O11' 0.043(9) 0.050(14) 0.048(12) 0.002(9) 0.005(8) 0.009(9) C12' 0.042(11) 0.037(10) 0.040(11) 0.005(8) -0.002(8) 0.018(8) C13' 0.06(2) 0.036(11) 0.053(15) 0.000(9) 0.004(13) 0.016(10) C14' 0.07(2) 0.040(11) 0.054(15) 0.003(9) 0.004(12) 0.015(10) C15' 0.047(11) 0.041(11) 0.044(11) 0.002(8) 0.007(8) 0.016(8) C16' 0.025(4) 0.015(3) 0.016(3) 0.004(2) 0.000(3) 0.007(3) C17' 0.026(4) 0.019(3) 0.018(3) 0.006(2) -0.001(3) 0.004(3) C18 0.037(4) 0.023(3) 0.028(4) 0.003(3) 0.010(3) 0.003(3) O18B 0.060(3) 0.030(3) 0.047(3) 0.014(2) 0.033(3) 0.014(3) O18A 0.085(4) 0.064(4) 0.100(5) 0.057(4) 0.070(4) 0.040(4) C19 0.035(4) 0.021(3) 0.024(3) -0.004(3) 0.005(3) 0.000(3) O19B 0.039(3) 0.021(3) 0.038(3) -0.007(2) 0.015(2) -0.006(2) O19A 0.032(3) 0.027(3) 0.059(3) -0.010(2) 0.015(2) -0.005(2) O21 0.018(3) 0.024(3) 0.055(3) 0.004(3) 0.001(2) 0.002(2) C22 0.033(4) 0.028(4) 0.030(4) 0.001(3) -0.005(3) 0.000(3) C23 0.036(5) 0.017(3) 0.037(4) -0.003(3) -0.007(3) 0.003(3) C24 0.030(4) 0.021(4) 0.037(4) -0.001(3) -0.003(3) -0.002(3) C25 0.031(4) 0.021(4) 0.028(4) -0.002(3) 0.007(3) 0.001(3) C26 0.029(4) 0.018(4) 0.028(4) -0.003(3) 0.001(3) 0.002(3) C27 0.016(4) 0.021(3) 0.031(4) -0.003(2) 0.000(3) 0.000(2) O21' 0.042(9) 0.056(13) 0.074(13) -0.005(10) 0.000(8) 0.001(8) C22' 0.030(10) 0.045(11) 0.066(12) -0.006(8) 0.006(8) 0.009(8) C23' 0.047(19) 0.041(11) 0.073(15) -0.001(9) 0.003(12) 0.010(9) C24' 0.06(2) 0.049(11) 0.076(15) -0.004(9) 0.005(12) 0.008(10) C25' 0.033(10) 0.049(11) 0.062(11) -0.003(8) -0.007(8) 0.014(8) C26' 0.016(4) 0.021(3) 0.031(4) -0.003(2) 0.000(3) 0.000(2) C27' 0.016(4) 0.021(3) 0.031(4) -0.003(2) 0.000(3) 0.000(2) C28 0.024(3) 0.022(3) 0.029(4) -0.003(3) 0.003(3) -0.002(2) O28B 0.043(3) 0.033(3) 0.070(4) -0.021(3) 0.034(3) -0.014(2) O28A 0.037(3) 0.026(3) 0.038(3) -0.011(2) 0.016(2) -0.011(2) C29 0.017(3) 0.033(4) 0.039(4) -0.007(3) 0.005(3) -0.001(3) O29B 0.028(3) 0.032(3) 0.047(3) 0.000(2) 0.014(2) 0.002(2) O29A 0.030(3) 0.026(3) 0.052(3) 0.003(2) 0.010(2) 0.005(2) O31 0.023(3) 0.026(3) 0.070(4) 0.000(3) 0.003(2) 0.008(2) C32 0.044(4) 0.028(4) 0.033(4) 0.003(3) -0.007(3) 0.008(3) C33 0.050(5) 0.025(4) 0.029(4) 0.002(3) 0.003(4) 0.014(4) C34 0.038(5) 0.020(4) 0.032(4) 0.006(3) 0.006(3) 0.001(3) C35 0.035(4) 0.025(4) 0.039(4) 0.000(3) 0.015(3) 0.000(3) C36 0.036(4) 0.031(3) 0.028(4) 0.006(3) 0.011(3) 0.003(3) C37 0.029(4) 0.029(3) 0.031(3) 0.003(3) 0.010(3) 0.012(3) O31' 0.053(10) 0.045(14) 0.053(12) 0.000(9) 0.006(8) 0.018(9) C32' 0.045(12) 0.039(10) 0.039(11) 0.004(8) 0.010(8) 0.020(9) C33' 0.05(2) 0.041(11) 0.023(13) 0.004(8) 0.008(12) 0.017(10) C34' 0.08(2) 0.046(11) 0.027(13) 0.000(9) 0.008(12) 0.009(11) C35' 0.054(12) 0.045(11) 0.041(11) -0.001(8) 0.000(8) 0.017(9) C36' 0.036(4) 0.031(3) 0.028(4) 0.006(3) 0.011(3) 0.003(3) C37' 0.029(4) 0.029(3) 0.031(3) 0.003(3) 0.010(3) 0.012(3) C38 0.037(4) 0.034(4) 0.039(4) 0.001(3) 0.018(3) -0.004(3) O38B 0.044(3) 0.034(3) 0.067(4) -0.018(3) 0.033(3) -0.015(2) O38A 0.037(3) 0.039(3) 0.068(4) 0.001(3) 0.027(3) -0.003(2) C39 0.031(3) 0.031(3) 0.030(4) 0.000(3) 0.014(3) 0.010(3) O39B 0.062(4) 0.049(3) 0.061(4) 0.025(3) 0.042(3) 0.035(3) O39A 0.039(3) 0.056(4) 0.045(3) 0.017(3) 0.023(2) 0.017(3) O41 0.050(3) 0.028(3) 0.022(2) -0.006(2) 0.008(2) -0.001(2) C42 0.026(3) 0.025(3) 0.026(4) 0.000(3) 0.002(3) -0.003(3) C43 0.029(3) 0.014(3) 0.030(4) -0.001(3) 0.004(3) 0.002(3) C44 0.031(4) 0.022(4) 0.037(4) -0.002(3) 0.013(3) -0.004(3) C45 0.028(3) 0.025(4) 0.038(4) 0.001(3) 0.012(3) 0.001(3) C46 0.019(3) 0.023(3) 0.027(3) -0.006(3) 0.002(3) 0.000(3) C47 0.020(3) 0.017(3) 0.023(3) -0.002(3) 0.004(3) -0.002(2) C48 0.020(3) 0.021(3) 0.027(4) -0.008(3) -0.004(3) 0.002(3) O48A 0.041(3) 0.031(3) 0.048(3) -0.019(2) -0.015(2) 0.017(2) O48B 0.061(3) 0.038(3) 0.052(3) -0.021(2) -0.030(3) 0.026(3) C49 0.029(4) 0.022(3) 0.025(4) 0.002(3) 0.006(3) -0.003(3) O49A 0.048(3) 0.023(3) 0.035(3) 0.007(2) -0.007(2) -0.013(2) O49B 0.039(3) 0.031(3) 0.033(3) 0.003(2) -0.008(2) -0.015(2) O51 0.048(3) 0.019(3) 0.021(2) 0.004(2) 0.006(2) 0.002(2) C52 0.021(3) 0.015(3) 0.035(4) 0.003(3) -0.006(3) 0.001(2) C53 0.024(3) 0.016(3) 0.041(4) 0.002(3) 0.004(3) 0.002(3) C54 0.024(3) 0.017(3) 0.049(5) 0.005(3) 0.002(3) -0.004(3) C55 0.022(3) 0.028(4) 0.041(4) 0.002(3) 0.016(3) 0.000(3) C56 0.017(3) 0.013(3) 0.028(3) -0.008(3) 0.001(2) 0.000(2) C57 0.019(3) 0.016(3) 0.018(3) -0.004(2) 0.007(2) -0.001(2) C58 0.024(3) 0.018(3) 0.025(4) -0.005(3) 0.001(3) 0.003(3) O58A 0.046(3) 0.023(3) 0.046(3) -0.015(2) -0.015(2) 0.016(2) O58B 0.047(3) 0.050(4) 0.063(3) -0.029(3) -0.032(3) 0.027(3) C59 0.023(3) 0.014(3) 0.020(3) 0.001(2) 0.005(2) -0.001(3) O59A 0.046(3) 0.026(3) 0.038(3) 0.012(2) -0.008(2) -0.012(2) O59B 0.038(3) 0.026(3) 0.038(3) 0.007(2) -0.007(2) -0.016(2) O61 0.064(3) 0.030(3) 0.028(3) 0.004(2) 0.007(2) 0.005(3) C62 0.031(4) 0.027(4) 0.048(4) -0.006(3) 0.015(3) -0.003(3) C63 0.037(4) 0.021(3) 0.039(4) -0.003(3) 0.011(3) 0.000(3) C64 0.032(4) 0.015(3) 0.037(4) -0.005(3) 0.004(3) -0.004(3) C65 0.030(3) 0.025(3) 0.034(4) -0.001(3) 0.002(3) 0.006(3) C66 0.030(3) 0.020(3) 0.027(3) 0.001(3) 0.001(3) 0.005(3) C67 0.030(3) 0.024(3) 0.030(4) 0.005(3) 0.002(3) -0.005(3) C68 0.038(4) 0.029(4) 0.030(4) -0.006(3) 0.002(3) 0.004(3) O68B 0.056(3) 0.029(3) 0.036(3) -0.010(2) -0.017(2) 0.016(3) O68A 0.088(4) 0.033(3) 0.028(3) -0.011(2) -0.016(3) 0.027(3) C69 0.036(4) 0.031(4) 0.028(4) 0.005(3) -0.003(3) -0.009(3) O69B 0.040(4) 0.028(3) 0.072(5) 0.019(3) -0.013(3) -0.011(3) O69A 0.033(3) 0.032(3) 0.065(5) 0.015(3) -0.010(3) -0.013(3) O71 0.055(3) 0.022(3) 0.020(2) -0.006(2) 0.003(2) -0.005(2) C72 0.031(3) 0.021(3) 0.028(4) -0.008(3) -0.002(3) -0.003(3) C73 0.029(3) 0.022(3) 0.038(4) -0.003(3) 0.005(3) -0.004(3) C74 0.034(4) 0.017(3) 0.056(5) -0.003(3) 0.008(3) -0.001(3) C75 0.039(4) 0.026(4) 0.046(4) -0.001(3) 0.022(3) -0.006(3) C76 0.029(3) 0.016(3) 0.025(3) 0.004(3) -0.001(3) -0.002(3) C77 0.029(3) 0.019(3) 0.016(3) 0.001(2) 0.001(2) -0.004(3) C78 0.035(4) 0.027(4) 0.032(4) 0.001(3) -0.004(3) -0.011(3) O78B 0.037(4) 0.026(3) 0.073(5) 0.018(3) 0.004(3) -0.011(3) O78A 0.032(3) 0.031(3) 0.068(5) 0.012(3) -0.008(3) -0.014(3) C79 0.032(4) 0.017(3) 0.016(3) 0.003(2) 0.004(3) 0.001(3) O79B 0.062(3) 0.028(3) 0.031(3) -0.009(2) -0.015(2) 0.014(2) O79A 0.057(3) 0.024(3) 0.030(3) -0.009(2) -0.009(2) 0.008(2) _geom_special_details ; All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag O1 C2 1.412(8) . ? O1 C5 1.427(9) . ? C2 H2 1.0000 . ? C2 C3 1.516(9) . ? C2 C7 1.521(13) . ? C3 H3 0.9500 . ? C3 C4 1.321(9) . ? C4 H4 0.9500 . ? C4 C5 1.515(9) . ? C5 H5 1.0000 . ? C5 C6 1.605(12) . ? C6 H6 1.0000 . ? C6 C7 1.571(10) . ? C6 C8 1.495(9) . ? C7 H7 1.0000 . ? C7 C9 1.480(9) . ? O1' C2' 1.38(2) . ? O1' C5' 1.41(2) . ? C2' H2' 1.0000 . ? C2' C3' 1.52(3) . ? C2' C7' 1.53(3) . ? C3' H3' 0.9500 . ? C3' C4' 1.34(3) . ? C4' H4' 0.9500 . ? C4' C5' 1.51(3) . ? C5' H5' 1.0000 . ? C5' C6' 1.60(3) . ? C6' H6' 1.0000 . ? C6' C7' 1.58(3) . ? C6' C8 1.487(13) . ? C7' H7' 1.0000 . ? C7' C9 1.490(13) . ? C8 O8A 1.291(8) . ? C8 O8B 1.242(8) . ? O8A H8A 0.8400 . ? C9 O9A 1.321(8) . ? C9 O9B 1.232(8) . ? O9A H9A 0.8400 . ? O11 C12 1.444(9) . ? O11 C15 1.424(9) . ? C12 H12 1.0000 . ? C12 C13 1.518(9) . ? C12 C17 1.503(10) . ? C13 H13 0.9500 . ? C13 C14 1.303(9) . ? C14 H14 0.9500 . ? C14 C15 1.514(10) . ? C15 H15 1.0000 . ? C15 C16 1.562(10) . ? C16 H16 1.0000 . ? C16 C17 1.562(9) . ? C16 C18 1.523(8) . ? C17 H17 1.0000 . ? C17 C19 1.525(8) . ? O11' C12' 1.44(3) . ? O11' C15' 1.42(3) . ? C12' H12' 1.0000 . ? C12' C13' 1.52(3) . ? C12' C17' 1.50(3) . ? C13' H13' 0.9500 . ? C13' C14' 1.29(3) . ? C14' H14' 0.9500 . ? C14' C15' 1.52(3) . ? C15' H15' 1.0000 . ? C15' C16' 1.57(3) . ? C16' H16' 1.0000 . ? C16' C17' 1.57(3) . ? C16' C18 1.524(14) . ? C17' H17' 1.0000 . ? C17' C19 1.530(13) . ? C18 O18B 1.250(8) . ? C18 O18A 1.253(8) . ? O18A H18A 0.8400 . ? C19 O19B 1.242(8) . ? C19 O19A 1.278(8) . ? O19A H19A 0.8400 . ? O21 C22 1.445(9) . ? O21 C25 1.437(9) . ? C22 H22 1.0000 . ? C22 C23 1.525(10) . ? C22 C27 1.591(11) . ? C23 H23 0.9500 . ? C23 C24 1.305(10) . ? C24 H24 0.9500 . ? C24 C25 1.504(10) . ? C25 H25 1.0000 . ? C25 C26 1.553(13) . ? C26 H26 1.0000 . ? C26 C27 1.570(11) . ? C26 C28 1.508(10) . ? C27 H27 1.0000 . ? C27 C29 1.512(10) . ? O21' C22' 1.47(3) . ? O21' C25' 1.40(3) . ? C22' H22' 1.0000 . ? C22' C23' 1.54(3) . ? C22' C27' 1.56(3) . ? C23' H23' 0.9500 . ? C23' C24' 1.29(3) . ? C24' H24' 0.9500 . ? C24' C25' 1.52(3) . ? C25' H25' 1.0000 . ? C25' C26' 1.53(3) . ? C26' H26' 1.0000 . ? C26' C27' 1.55(3) . ? C26' C28 1.50(2) . ? C27' H27' 1.0000 . ? C27' C29 1.48(2) . ? C28 O28B 1.230(8) . ? C28 O28A 1.306(8) . ? O28A H28A 0.8400 . ? C29 O29B 1.232(8) . ? C29 O29A 1.289(8) . ? O29A H29A 0.8400 . ? O31 C32 1.418(9) . ? O31 C35 1.424(9) . ? C32 H32 1.0000 . ? C32 C33 1.509(10) . ? C32 C37 1.617(11) . ? C33 H33 0.9500 . ? C33 C34 1.328(10) . ? C34 H34 0.9500 . ? C34 C35 1.525(10) . ? C35 H35 1.0000 . ? C35 C36 1.536(14) . ? C36 H36 1.0000 . ? C36 C37 1.574(10) . ? C36 C38 1.490(9) . ? C37 H37 1.0000 . ? C37 C39 1.498(9) . ? O31' C32' 1.42(3) . ? O31' C35' 1.40(3) . ? C32' H32' 1.0000 . ? C32' C33' 1.49(3) . ? C32' C37' 1.59(3) . ? C33' H33' 0.9500 . ? C33' C34' 1.35(3) . ? C34' H34' 0.9500 . ? C34' C35' 1.53(3) . ? C35' H35' 1.0000 . ? C35' C36' 1.55(3) . ? C36' H36' 1.0000 . ? C36' C37' 1.58(3) . ? C36' C38 1.495(14) . ? C37' H37' 1.0000 . ? C37' C39 1.493(14) . ? C38 O38B 1.232(8) . ? C38 O38A 1.291(8) . ? O38A H38A 0.8400 . ? C39 O39B 1.271(8) . ? C39 O39A 1.271(8) . ? O39A H39A 0.8400 . ? O41 C42 1.421(8) . ? O41 C45 1.412(9) . ? C42 H42 1.0000 . ? C42 C43 1.530(10) . ? C42 C47 1.548(9) . ? C43 H43 0.9500 . ? C43 C44 1.303(9) . ? C44 H44 0.9500 . ? C44 C45 1.523(11) . ? C45 H45 1.0000 . ? C45 C46 1.575(10) . ? C46 H46 1.0000 . ? C46 C47 1.562(10) . ? C46 C48 1.504(10) . ? C47 H47 1.0000 . ? C47 C49 1.493(10) . ? C48 O48A 1.256(8) . ? C48 O48B 1.249(8) . ? O48A H48A 0.8400 . ? C49 O49A 1.310(8) . ? C49 O49B 1.224(8) . ? O49A H49A 0.8400 . ? O51 C52 1.439(8) . ? O51 C55 1.438(8) . ? C52 H52 1.0000 . ? C52 C53 1.493(10) . ? C52 C57 1.537(9) . ? C53 H53 0.9500 . ? C53 C54 1.316(10) . ? C54 H54 0.9500 . ? C54 C55 1.498(11) . ? C55 H55 1.0000 . ? C55 C56 1.583(10) . ? C56 H56 1.0000 . ? C56 C57 1.565(9) . ? C56 C58 1.492(9) . ? C57 H57 1.0000 . ? C57 C59 1.503(9) . ? C58 O58A 1.270(8) . ? C58 O58B 1.229(8) . ? O58A H58A 0.8400 . ? C59 O59A 1.306(8) . ? C59 O59B 1.242(8) . ? O59A H59A 0.8400 . ? O61 C62 1.400(9) . ? O61 C65 1.425(9) . ? C62 H62 1.0000 . ? C62 C63 1.533(11) . ? C62 C67 1.573(10) . ? C63 H63 0.9500 . ? C63 C64 1.315(10) . ? C64 H64 0.9500 . ? C64 C65 1.519(10) . ? C65 H65 1.0000 . ? C65 C66 1.559(10) . ? C66 H66 1.0000 . ? C66 C67 1.560(10) . ? C66 C68 1.500(10) . ? C67 H67 1.0000 . ? C67 C69 1.503(11) . ? C68 O68B 1.208(9) . ? C68 O68A 1.298(9) . ? O68A H68A 0.8400 . ? C69 O69B 1.247(9) . ? C69 O69A 1.332(8) . ? C69 O69C 1.337(15) . ? C69 O69D 1.245(16) . ? O69A H69A 0.8400 . ? O69C H69C 0.8400 . ? O71 C72 1.446(8) . ? O71 C75 1.426(9) . ? C72 H72 1.0000 . ? C72 C73 1.502(10) . ? C72 C77 1.559(9) . ? C73 H73 0.9500 . ? C73 C74 1.339(10) . ? C74 H74 0.9500 . ? C74 C75 1.496(11) . ? C75 H75 1.0000 . ? C75 C76 1.580(10) . ? C76 H76 1.0000 . ? C76 C77 1.548(10) . ? C76 C78 1.491(10) . ? C77 H77 1.0000 . ? C77 C79 1.512(10) . ? C78 O78B 1.226(10) . ? C78 O78A 1.318(8) . ? C78 O78C 1.324(15) . ? C78 O78D 1.22(3) . ? O78A H78A 0.8400 . ? O78C H78C 0.8400 . ? C79 O79B 1.220(8) . ? C79 O79A 1.300(8) . ? O79A H79A 0.8400 . ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C2 O1 C5 96.4(5) . . ? O1 C2 H2 114.9 . . ? O1 C2 C3 102.8(5) . . ? O1 C2 C7 99.5(6) . . ? C3 C2 H2 114.9 . . ? C3 C2 C7 108.1(6) . . ? C7 C2 H2 114.9 . . ? C2 C3 H3 127.3 . . ? C4 C3 C2 105.3(6) . . ? C4 C3 H3 127.3 . . ? C3 C4 H4 127.4 . . ? C3 C4 C5 105.1(6) . . ? C5 C4 H4 127.4 . . ? O1 C5 C4 102.8(6) . . ? O1 C5 H5 115.2 . . ? O1 C5 C6 102.7(6) . . ? C4 C5 H5 115.2 . . ? C4 C5 C6 103.9(6) . . ? C6 C5 H5 115.2 . . ? C5 C6 H6 110.0 . . ? C7 C6 C5 96.3(7) . . ? C7 C6 H6 110.0 . . ? C8 C6 C5 112.4(7) . . ? C8 C6 H6 110.0 . . ? C8 C6 C7 117.4(8) . . ? C2 C7 C6 103.6(7) . . ? C2 C7 H7 108.0 . . ? C6 C7 H7 108.0 . . ? C9 C7 C2 113.6(7) . . ? C9 C7 C6 115.2(8) . . ? C9 C7 H7 108.0 . . ? C2' O1' C5' 97.9(19) . . ? O1' C2' H2' 114.3 . . ? O1' C2' C3' 104(2) . . ? O1' C2' C7' 97(2) . . ? C3' C2' H2' 114.3 . . ? C3' C2' C7' 111(3) . . ? C7' C2' H2' 114.3 . . ? C2' C3' H3' 126.9 . . ? C4' C3' C2' 106(2) . . ? C4' C3' H3' 126.9 . . ? C3' C4' H4' 128.4 . . ? C3' C4' C5' 103(2) . . ? C5' C4' H4' 128.4 . . ? O1' C5' C4' 105(2) . . ? O1' C5' H5' 115.9 . . ? O1' C5' C6' 100(2) . . ? C4' C5' H5' 115.9 . . ? C4' C5' C6' 102(2) . . ? C6' C5' H5' 115.9 . . ? C5' C6' H6' 114.1 . . ? C7' C6' C5' 99(2) . . ? C7' C6' H6' 114.1 . . ? C8 C6' C5' 107(2) . . ? C8 C6' H6' 114.1 . . ? C8 C6' C7' 108(3) . . ? C2' C7' C6' 99.6(18) . . ? C2' C7' H7' 98.6 . . ? C6' C7' H7' 98.6 . . ? C9 C7' C2' 133(3) . . ? C9 C7' C6' 120(3) . . ? C9 C7' H7' 98.6 . . ? O8A C8 C6 118.7(7) . . ? O8A C8 C6' 114.1(17) . . ? O8B C8 C6 119.1(7) . . ? O8B C8 C6' 123.4(17) . . ? O8B C8 O8A 122.2(7) . . ? C8 O8A H8A 109.5 . . ? O9A C9 C7 114.1(6) . . ? O9A C9 C7' 105(2) . . ? O9B C9 C7 123.1(7) . . ? O9B C9 C7' 133(2) . . ? O9B C9 O9A 122.8(6) . . ? C9 O9A H9A 109.5 . . ? C15 O11 C12 94.7(5) . . ? O11 C12 H12 114.5 . . ? O11 C12 C13 102.6(6) . . ? O11 C12 C17 101.8(6) . . ? C13 C12 H12 114.5 . . ? C17 C12 H12 114.5 . . ? C17 C12 C13 107.4(6) . . ? C12 C13 H13 127.7 . . ? C14 C13 C12 104.7(6) . . ? C14 C13 H13 127.7 . . ? C13 C14 H14 126.9 . . ? C13 C14 C15 106.2(7) . . ? C15 C14 H14 126.9 . . ? O11 C15 C14 102.7(6) . . ? O11 C15 H15 115.1 . . ? O11 C15 C16 101.9(6) . . ? C14 C15 H15 115.1 . . ? C14 C15 C16 105.2(6) . . ? C16 C15 H15 115.1 . . ? C15 C16 H16 110.0 . . ? C17 C16 C15 99.1(5) . . ? C17 C16 H16 110.0 . . ? C18 C16 C15 107.9(6) . . ? C18 C16 H16 110.0 . . ? C18 C16 C17 119.2(6) . . ? C12 C17 C16 101.5(5) . . ? C12 C17 H17 109.7 . . ? C12 C17 C19 112.9(6) . . ? C16 C17 H17 109.7 . . ? C19 C17 C16 113.0(6) . . ? C19 C17 H17 109.7 . . ? C15' O11' C12' 96(2) . . ? O11' C12' H12' 115.1 . . ? O11' C12' C13' 105(2) . . ? O11' C12' C17' 99(2) . . ? C13' C12' H12' 115.1 . . ? C17' C12' H12' 115.1 . . ? C17' C12' C13' 107(3) . . ? C12' C13' H13' 126.2 . . ? C14' C13' C12' 108(2) . . ? C14' C13' H13' 126.2 . . ? C13' C14' H14' 128.5 . . ? C13' C14' C15' 103(2) . . ? C15' C14' H14' 128.5 . . ? O11' C15' C14' 103(2) . . ? O11' C15' H15' 116.5 . . ? O11' C15' C16' 98(2) . . ? C14' C15' H15' 116.5 . . ? C14' C15' C16' 104(3) . . ? C16' C15' H15' 116.5 . . ? C15' C16' H16' 118.4 . . ? C15' C16' C17' 103(2) . . ? C17' C16' H16' 118.4 . . ? C18 C16' C15' 94.6(19) . . ? C18 C16' H16' 118.4 . . ? C18 C16' C17' 100(2) . . ? C12' C17' C16' 96.4(18) . . ? C12' C17' H17' 105.7 . . ? C12' C17' C19 108(2) . . ? C16' C17' H17' 105.7 . . ? C19 C17' C16' 133(3) . . ? C19 C17' H17' 105.7 . . ? O18B C18 C16 123.6(6) . . ? O18B C18 C16' 109.3(13) . . ? O18B C18 O18A 122.1(7) . . ? O18A C18 C16 114.2(6) . . ? O18A C18 C16' 123.1(14) . . ? C18 O18A H18A 109.5 . . ? O19B C19 C17 121.1(6) . . ? O19B C19 C17' 114.9(16) . . ? O19B C19 O19A 124.7(6) . . ? O19A C19 C17 113.9(6) . . ? O19A C19 C17' 119.0(16) . . ? C19 O19A H19A 109.5 . . ? C25 O21 C22 95.2(5) . . ? O21 C22 H22 114.7 . . ? O21 C22 C23 102.2(6) . . ? O21 C22 C27 103.1(6) . . ? C23 C22 H22 114.7 . . ? C23 C22 C27 106.0(6) . . ? C27 C22 H22 114.7 . . ? C22 C23 H23 127.8 . . ? C24 C23 C22 104.4(7) . . ? C24 C23 H23 127.8 . . ? C23 C24 H24 126.4 . . ? C23 C24 C25 107.2(7) . . ? C25 C24 H24 126.4 . . ? O21 C25 C24 101.9(6) . . ? O21 C25 H25 115.4 . . ? O21 C25 C26 100.8(6) . . ? C24 C25 H25 115.4 . . ? C24 C25 C26 106.1(6) . . ? C26 C25 H25 115.4 . . ? C25 C26 H26 109.6 . . ? C25 C26 C27 103.1(7) . . ? C27 C26 H26 109.6 . . ? C28 C26 C25 111.1(7) . . ? C28 C26 H26 109.6 . . ? C28 C26 C27 113.8(7) . . ? C22 C27 H27 109.7 . . ? C26 C27 C22 97.5(7) . . ? C26 C27 H27 109.7 . . ? C29 C27 C22 111.2(6) . . ? C29 C27 C26 118.2(7) . . ? C29 C27 H27 109.7 . . ? C25' O21' C22' 95.0(19) . . ? O21' C22' H22' 116.4 . . ? O21' C22' C23' 103(2) . . ? O21' C22' C27' 102(2) . . ? C23' C22' H22' 116.4 . . ? C23' C22' C27' 101(2) . . ? C27' C22' H22' 116.4 . . ? C22' C23' H23' 128.8 . . ? C24' C23' C22' 102(2) . . ? C24' C23' H23' 128.8 . . ? C23' C24' H24' 125.3 . . ? C23' C24' C25' 109(2) . . ? C25' C24' H24' 125.4 . . ? O21' C25' C24' 101(2) . . ? O21' C25' H25' 114.3 . . ? O21' C25' C26' 103(2) . . ? C24' C25' H25' 114.3 . . ? C24' C25' C26' 109(3) . . ? C26' C25' H25' 114.3 . . ? C25' C26' H26' 104.3 . . ? C25' C26' C27' 98(2) . . ? C27' C26' H26' 104.3 . . ? C28 C26' C25' 109(3) . . ? C28 C26' H26' 104.3 . . ? C28 C26' C27' 134(3) . . ? C22' C27' H27' 117.9 . . ? C26' C27' C22' 103(2) . . ? C26' C27' H27' 117.9 . . ? C29 C27' C22' 97(2) . . ? C29 C27' C26' 100(3) . . ? C29 C27' H27' 117.9 . . ? O28B C28 C26 121.6(7) . . ? O28B C28 C26' 123.8(19) . . ? O28B C28 O28A 123.3(7) . . ? O28A C28 C26 114.7(7) . . ? O28A C28 C26' 112.4(19) . . ? C28 O28A H28A 109.5 . . ? O29B C29 C27 119.9(7) . . ? O29B C29 C27' 125.3(15) . . ? O29B C29 O29A 123.0(7) . . ? O29A C29 C27 117.1(7) . . ? O29A C29 C27' 109.7(14) . . ? C29 O29A H29A 109.5 . . ? C32 O31 C35 97.1(5) . . ? O31 C32 H32 115.5 . . ? O31 C32 C33 102.8(6) . . ? O31 C32 C37 100.5(6) . . ? C33 C32 H32 115.5 . . ? C33 C32 C37 105.0(6) . . ? C37 C32 H32 115.5 . . ? C32 C33 H33 127.3 . . ? C34 C33 C32 105.5(7) . . ? C34 C33 H33 127.3 . . ? C33 C34 H34 127.4 . . ? C33 C34 C35 105.2(6) . . ? C35 C34 H34 127.4 . . ? O31 C35 C34 101.9(6) . . ? O31 C35 H35 114.8 . . ? O31 C35 C36 101.5(6) . . ? C34 C35 H35 114.8 . . ? C34 C35 C36 107.3(6) . . ? C36 C35 H35 114.8 . . ? C35 C36 H36 108.7 . . ? C35 C36 C37 101.4(7) . . ? C37 C36 H36 108.7 . . ? C38 C36 C35 113.4(8) . . ? C38 C36 H36 108.7 . . ? C38 C36 C37 115.6(8) . . ? C32 C37 H37 110.6 . . ? C36 C37 C32 98.9(7) . . ? C36 C37 H37 110.6 . . ? C39 C37 C32 107.9(6) . . ? C39 C37 C36 117.5(7) . . ? C39 C37 H37 110.6 . . ? C35' O31' C32' 99(2) . . ? O31' C32' H32' 115.4 . . ? O31' C32' C33' 101(2) . . ? O31' C32' C37' 98(2) . . ? C33' C32' H32' 115.4 . . ? C33' C32' C37' 109(2) . . ? C37' C32' H32' 115.4 . . ? C32' C33' H33' 128.3 . . ? C34' C33' C32' 103(2) . . ? C34' C33' H33' 128.3 . . ? C33' C34' H34' 127.3 . . ? C33' C34' C35' 105(2) . . ? C35' C34' H34' 127.3 . . ? O31' C35' C34' 104(2) . . ? O31' C35' H35' 115.4 . . ? O31' C35' C36' 99(3) . . ? C34' C35' H35' 115.4 . . ? C34' C35' C36' 106(3) . . ? C36' C35' H35' 115.4 . . ? C35' C36' H36' 102.1 . . ? C35' C36' C37' 98(2) . . ? C37' C36' H36' 102.1 . . ? C38 C36' C35' 123(4) . . ? C38 C36' H36' 102.1 . . ? C38 C36' C37' 125(4) . . ? C32' C37' H37' 114.2 . . ? C36' C37' C32' 102(2) . . ? C36' C37' H37' 114.2 . . ? C39 C37' C32' 106(2) . . ? C39 C37' C36' 106(3) . . ? C39 C37' H37' 114.2 . . ? O38B C38 C36 121.9(8) . . ? O38B C38 C36' 121(3) . . ? O38B C38 O38A 122.8(7) . . ? O38A C38 C36 115.2(8) . . ? O38A C38 C36' 115(3) . . ? C38 O38A H38A 109.5 . . ? O39B C39 C37 121.3(6) . . ? O39B C39 C37' 109.0(15) . . ? O39B C39 O39A 121.2(7) . . ? O39A C39 C37 117.5(6) . . ? O39A C39 C37' 127.6(16) . . ? C39 O39A H39A 109.5 . . ? C45 O41 C42 96.6(5) . . ? O41 C42 H42 115.2 . . ? O41 C42 C43 101.7(5) . . ? O41 C42 C47 100.6(5) . . ? C43 C42 H42 115.2 . . ? C43 C42 C47 107.1(5) . . ? C47 C42 H42 115.2 . . ? C42 C43 H43 127.1 . . ? C44 C43 C42 105.8(6) . . ? C44 C43 H43 127.1 . . ? C43 C44 H44 127.5 . . ? C43 C44 C45 105.0(6) . . ? C45 C44 H44 127.5 . . ? O41 C45 C44 102.3(6) . . ? O41 C45 H45 115.0 . . ? O41 C45 C46 102.0(5) . . ? C44 C45 H45 115.0 . . ? C44 C45 C46 106.0(6) . . ? C46 C45 H45 115.0 . . ? C45 C46 H46 109.7 . . ? C47 C46 C45 99.2(5) . . ? C47 C46 H46 109.7 . . ? C48 C46 C45 111.0(6) . . ? C48 C46 H46 109.7 . . ? C48 C46 C47 116.9(5) . . ? C42 C47 C46 101.2(5) . . ? C42 C47 H47 109.4 . . ? C46 C47 H47 109.4 . . ? C49 C47 C42 112.1(6) . . ? C49 C47 C46 115.1(5) . . ? C49 C47 H47 109.4 . . ? O48A C48 C46 119.3(6) . . ? O48B C48 C46 118.2(6) . . ? O48B C48 O48A 122.5(7) . . ? C48 O48A H48A 109.5 . . ? O49A C49 C47 114.4(6) . . ? O49B C49 C47 122.8(7) . . ? O49B C49 O49A 122.8(7) . . ? C49 O49A H49A 109.5 . . ? C55 O51 C52 95.4(5) . . ? O51 C52 H52 115.0 . . ? O51 C52 C53 102.6(6) . . ? O51 C52 C57 100.1(5) . . ? C53 C52 H52 115.0 . . ? C53 C52 C57 107.5(6) . . ? C57 C52 H52 115.0 . . ? C52 C53 H53 127.0 . . ? C54 C53 C52 106.0(6) . . ? C54 C53 H53 127.0 . . ? C53 C54 H54 127.2 . . ? C53 C54 C55 105.5(6) . . ? C55 C54 H54 127.2 . . ? O51 C55 C54 102.7(5) . . ? O51 C55 H55 115.2 . . ? O51 C55 C56 101.4(5) . . ? C54 C55 H55 115.2 . . ? C54 C55 C56 105.3(6) . . ? C56 C55 H55 115.2 . . ? C55 C56 H56 109.2 . . ? C57 C56 C55 98.8(5) . . ? C57 C56 H56 109.2 . . ? C58 C56 C55 111.4(5) . . ? C58 C56 H56 109.2 . . ? C58 C56 C57 118.4(5) . . ? C52 C57 C56 102.0(5) . . ? C52 C57 H57 109.0 . . ? C56 C57 H57 109.0 . . ? C59 C57 C52 112.7(6) . . ? C59 C57 C56 114.8(5) . . ? C59 C57 H57 109.0 . . ? O58A C58 C56 117.2(6) . . ? O58B C58 C56 119.8(6) . . ? O58B C58 O58A 122.8(7) . . ? C58 O58A H58A 109.5 . . ? O59A C59 C57 114.8(6) . . ? O59B C59 C57 121.5(6) . . ? O59B C59 O59A 123.6(7) . . ? C59 O59A H59A 109.5 . . ? C62 O61 C65 96.0(6) . . ? O61 C62 H62 114.6 . . ? O61 C62 C63 103.4(6) . . ? O61 C62 C67 102.4(6) . . ? C63 C62 H62 114.6 . . ? C63 C62 C67 105.7(6) . . ? C67 C62 H62 114.6 . . ? C62 C63 H63 128.2 . . ? C64 C63 C62 103.7(6) . . ? C64 C63 H63 128.2 . . ? C63 C64 H64 126.9 . . ? C63 C64 C65 106.1(6) . . ? C65 C64 H64 126.9 . . ? O61 C65 C64 102.1(6) . . ? O61 C65 H65 114.9 . . ? O61 C65 C66 101.1(6) . . ? C64 C65 H65 114.9 . . ? C64 C65 C66 107.4(6) . . ? C66 C65 H65 114.9 . . ? C65 C66 H66 109.3 . . ? C65 C66 C67 100.3(5) . . ? C67 C66 H66 109.3 . . ? C68 C66 C65 111.5(6) . . ? C68 C66 H66 109.3 . . ? C68 C66 C67 116.7(6) . . ? C62 C67 H67 110.6 . . ? C66 C67 C62 99.5(6) . . ? C66 C67 H67 110.6 . . ? C69 C67 C62 109.6(6) . . ? C69 C67 C66 115.5(6) . . ? C69 C67 H67 110.6 . . ? O68B C68 C66 123.5(7) . . ? O68B C68 O68A 123.2(7) . . ? O68A C68 C66 113.2(7) . . ? C68 O68A H68A 109.5 . . ? O69B C69 C67 126.3(7) . . ? O69B C69 O69A 121.9(7) . . ? O69A C69 C67 111.7(7) . . ? O69C C69 C67 116.4(16) . . ? O69D C69 C67 122.5(18) . . ? O69D C69 O69C 121.0(17) . . ? C69 O69A H69A 109.5 . . ? C69 O69C H69C 109.5 . . ? C75 O71 C72 95.2(5) . . ? O71 C72 H72 115.0 . . ? O71 C72 C73 102.8(6) . . ? O71 C72 C77 99.8(5) . . ? C73 C72 H72 115.0 . . ? C73 C72 C77 107.3(6) . . ? C77 C72 H72 115.0 . . ? C72 C73 H73 127.3 . . ? C74 C73 C72 105.4(6) . . ? C74 C73 H73 127.3 . . ? C73 C74 H74 127.6 . . ? C73 C74 C75 104.8(7) . . ? C75 C74 H74 127.6 . . ? O71 C75 C74 103.9(6) . . ? O71 C75 H75 114.8 . . ? O71 C75 C76 101.3(6) . . ? C74 C75 H75 114.8 . . ? C74 C75 C76 105.9(6) . . ? C76 C75 H75 114.8 . . ? C75 C76 H76 109.7 . . ? C77 C76 C75 99.7(5) . . ? C77 C76 H76 109.7 . . ? C78 C76 C75 109.4(6) . . ? C78 C76 H76 109.7 . . ? C78 C76 C77 117.9(6) . . ? C72 C77 H77 109.2 . . ? C76 C77 C72 101.3(5) . . ? C76 C77 H77 109.2 . . ? C79 C77 C72 111.8(5) . . ? C79 C77 C76 115.7(5) . . ? C79 C77 H77 109.2 . . ? O78B C78 C76 125.3(7) . . ? O78B C78 O78A 123.0(7) . . ? O78A C78 C76 111.4(7) . . ? O78C C78 C76 114.7(16) . . ? O78D C78 C76 123(2) . . ? O78D C78 O78C 122(2) . . ? C78 O78A H78A 109.5 . . ? C78 O78C H78C 109.5 . . ? O79B C79 C77 123.3(6) . . ? O79B C79 O79A 124.1(7) . . ? O79A C79 C77 112.4(6) . . ? C79 O79A H79A 109.5 . . ? loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_site_symmetry_A O8A H8A O19B 0.84 1.84 2.678(7) 173.1 . O9A H9A O28B 0.84 1.78 2.616(8) 174.5 2_646 O18A H18A O39B 0.84 1.82 2.642(8) 164.9 1_554 O19A H19A O8B 0.84 1.77 2.593(7) 165.7 . O28A H28A O9B 0.84 1.83 2.665(7) 176.4 2_656 O29A H29A O38B 0.84 1.80 2.626(8) 168.3 2_656 O38A H38A O29B 0.84 1.86 2.673(8) 164.1 2_646 O39A H39A O18B 0.84 1.85 2.673(8) 166.3 1_556 O48A H48A O58B 0.84 1.81 2.643(8) 170.7 . O49A H49A O59B 0.84 1.77 2.605(7) 171.0 1_455 O58A H58A O48B 0.84 1.81 2.647(7) 173.3 . O59A H59A O49B 0.84 1.80 2.634(7) 174.1 1_655 O68A H68A O79B 0.84 1.79 2.630(8) 176.2 1_655 O69A H69A O78B 0.84 1.90 2.737(9) 178.2 . O69C H69C O78D 0.84 1.88 2.63(6) 146.4 . O78A H78A O69B 0.84 1.87 2.687(9) 164.2 . O78C H78C O69D 0.84 1.88 2.69(5) 160.8 . O79A H79A O68B 0.84 1.80 2.636(8) 178.5 1_455 loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag O1 C2 C3 C4 -31.9(7) . . . . ? O1 C2 C7 C6 42.0(7) . . . . ? O1 C2 C7 C9 -83.8(8) . . . . ? O1 C5 C6 C7 -30.7(7) . . . . ? O1 C5 C6 C8 92.5(8) . . . . ? C2 O1 C5 C4 -48.8(6) . . . . ? C2 O1 C5 C6 59.0(6) . . . . ? C2 C3 C4 C5 0.4(8) . . . . ? C2 C7 C9 O9A 176.4(7) . . . . ? C2 C7 C9 O9B -6.4(12) . . . . ? C3 C2 C7 C6 -65.0(8) . . . . ? C3 C2 C7 C9 169.3(7) . . . . ? C3 C4 C5 O1 30.8(8) . . . . ? C3 C4 C5 C6 -76.0(8) . . . . ? C4 C5 C6 C7 76.1(7) . . . . ? C4 C5 C6 C8 -160.7(8) . . . . ? C5 O1 C2 C3 49.0(6) . . . . ? C5 O1 C2 C7 -62.3(6) . . . . ? C5 C6 C7 C2 -6.4(8) . . . . ? C5 C6 C7 C9 118.4(8) . . . . ? C5 C6 C8 O8A -53.4(10) . . . . ? C5 C6 C8 O8B 126.9(8) . . . . ? C6 C7 C9 O9A 57.0(11) . . . . ? C6 C7 C9 O9B -125.8(9) . . . . ? C7 C2 C3 C4 72.7(8) . . . . ? C7 C6 C8 O8A 57.0(11) . . . . ? C7 C6 C8 O8B -122.7(10) . . . . ? O1' C2' C3' C4' 30(4) . . . . ? O1' C2' C7' C6' -48(3) . . . . ? O1' C2' C7' C9 102(5) . . . . ? O1' C5' C6' C7' 26(3) . . . . ? O1' C5' C6' C8 -86(3) . . . . ? C2' O1' C5' C4' 46(3) . . . . ? C2' O1' C5' C6' -59(2) . . . . ? C2' C3' C4' C5' -1(4) . . . . ? C2' C7' C9 O9A -66(5) . . . . ? C2' C7' C9 O9B 111(5) . . . . ? C3' C2' C7' C6' 60(3) . . . . ? C3' C2' C7' C9 -151(4) . . . . ? C3' C4' C5' O1' -28(4) . . . . ? C3' C4' C5' C6' 75(3) . . . . ? C4' C5' C6' C7' -82(3) . . . . ? C4' C5' C6' C8 166(3) . . . . ? C5' O1' C2' C3' -45(3) . . . . ? C5' O1' C2' C7' 68(2) . . . . ? C5' C6' C7' C2' 12(3) . . . . ? C5' C6' C7' C9 -143(4) . . . . ? C5' C6' C8 O8A -176.5(17) . . . . ? C5' C6' C8 O8B -4(3) . . . . ? C6' C7' C9 O9A 78(4) . . . . ? C6' C7' C9 O9B -105(4) . . . . ? C7' C2' C3' C4' -74(4) . . . . ? C7' C6' C8 O8A 78(3) . . . . ? C7' C6' C8 O8B -109(3) . . . . ? C8 C6 C7 C2 -125.7(8) . . . . ? C8 C6 C7 C9 -1.0(13) . . . . ? C8 C6' C7' C2' 123(3) . . . . ? C8 C6' C7' C9 -32(5) . . . . ? O11 C12 C13 C14 32.7(8) . . . . ? O11 C12 C17 C16 -38.1(6) . . . . ? O11 C12 C17 C19 83.1(7) . . . . ? O11 C15 C16 C17 35.3(6) . . . . ? O11 C15 C16 C18 -89.5(6) . . . . ? C12 O11 C15 C14 49.5(6) . . . . ? C12 O11 C15 C16 -59.3(6) . . . . ? C12 C13 C14 C15 -0.6(8) . . . . ? C12 C17 C19 O19B 10.9(9) . . . . ? C12 C17 C19 O19A -174.7(6) . . . . ? C13 C12 C17 C16 69.3(7) . . . . ? C13 C12 C17 C19 -169.5(6) . . . . ? C13 C14 C15 O11 -32.2(8) . . . . ? C13 C14 C15 C16 74.1(8) . . . . ? C14 C15 C16 C17 -71.5(7) . . . . ? C14 C15 C16 C18 163.7(6) . . . . ? C15 O11 C12 C13 -50.1(6) . . . . ? C15 O11 C12 C17 61.1(6) . . . . ? C15 C16 C17 C12 1.9(6) . . . . ? C15 C16 C17 C19 -119.2(6) . . . . ? C15 C16 C18 O18B 62.3(9) . . . . ? C15 C16 C18 O18A -114.3(8) . . . . ? C16 C17 C19 O19B 125.3(7) . . . . ? C16 C17 C19 O19A -60.2(8) . . . . ? C17 C12 C13 C14 -74.1(8) . . . . ? C17 C16 C18 O18B -49.4(10) . . . . ? C17 C16 C18 O18A 134.0(8) . . . . ? O11' C12' C13' C14' -15(4) . . . . ? O11' C12' C17' C16' 49(2) . . . . ? O11' C12' C17' C19 -90(3) . . . . ? O11' C15' C16' C17' -26(3) . . . . ? O11' C15' C16' C18 75(2) . . . . ? C12' O11' C15' C14' -50(3) . . . . ? C12' O11' C15' C16' 57(2) . . . . ? C12' C13' C14' C15' -16(5) . . . . ? C12' C17' C19 O19B -126(2) . . . . ? C12' C17' C19 O19A 67(3) . . . . ? C13' C12' C17' C16' -59(3) . . . . ? C13' C12' C17' C19 162(3) . . . . ? C13' C14' C15' O11' 44(4) . . . . ? C13' C14' C15' C16' -58(4) . . . . ? C14' C15' C16' C17' 80(3) . . . . ? C14' C15' C16' C18 -179(2) . . . . ? C15' O11' C12' C13' 40(3) . . . . ? C15' O11' C12' C17' -70(2) . . . . ? C15' C16' C17' C12' -14(3) . . . . ? C15' C16' C17' C19 107(3) . . . . ? C15' C16' C18 O18B -178.6(15) . . . . ? C15' C16' C18 O18A 27(2) . . . . ? C16' C17' C19 O19B 117(3) . . . . ? C16' C17' C19 O19A -51(4) . . . . ? C17' C12' C13' C14' 89(4) . . . . ? C17' C16' C18 O18B -74.2(19) . . . . ? C17' C16' C18 O18A 131.5(17) . . . . ? C18 C16 C17 C12 118.3(7) . . . . ? C18 C16 C17 C19 -2.8(9) . . . . ? C18 C16' C17' C12' -111(2) . . . . ? C18 C16' C17' C19 10(4) . . . . ? O21 C22 C23 C24 -32.5(8) . . . . ? O21 C22 C27 C26 34.9(7) . . . . ? O21 C22 C27 C29 -89.3(7) . . . . ? O21 C25 C26 C27 -37.8(7) . . . . ? O21 C25 C26 C28 84.4(7) . . . . ? C22 O21 C25 C24 -49.5(7) . . . . ? C22 O21 C25 C26 59.7(6) . . . . ? C22 C23 C24 C25 0.3(9) . . . . ? C22 C27 C29 O29B -123.3(8) . . . . ? C22 C27 C29 O29A 57.1(9) . . . . ? C23 C22 C27 C26 -72.1(7) . . . . ? C23 C22 C27 C29 163.7(7) . . . . ? C23 C24 C25 O21 32.1(8) . . . . ? C23 C24 C25 C26 -73.0(8) . . . . ? C24 C25 C26 C27 68.1(8) . . . . ? C24 C25 C26 C28 -169.7(7) . . . . ? C25 O21 C22 C23 49.9(6) . . . . ? C25 O21 C22 C27 -59.9(6) . . . . ? C25 C26 C27 C22 1.7(7) . . . . ? C25 C26 C27 C29 120.7(7) . . . . ? C25 C26 C28 O28B 10.0(11) . . . . ? C25 C26 C28 O28A -176.8(6) . . . . ? C26 C27 C29 O29B 125.2(8) . . . . ? C26 C27 C29 O29A -54.4(10) . . . . ? C27 C22 C23 C24 75.2(8) . . . . ? C27 C26 C28 O28B 125.8(8) . . . . ? C27 C26 C28 O28A -61.1(10) . . . . ? O21' C22' C23' C24' 31(4) . . . . ? O21' C22' C27' C26' -26(3) . . . . ? O21' C22' C27' C29 76(2) . . . . ? O21' C25' C26' C27' 46(3) . . . . ? O21' C25' C26' C28 -96(3) . . . . ? C22' O21' C25' C24' 49(3) . . . . ? C22' O21' C25' C26' -63(2) . . . . ? C22' C23' C24' C25' 1(4) . . . . ? C22' C27' C29 O29B 19(2) . . . . ? C22' C27' C29 O29A -177.0(14) . . . . ? C23' C22' C27' C26' 80(3) . . . . ? C23' C22' C27' C29 -178(2) . . . . ? C23' C24' C25' O21' -34(4) . . . . ? C23' C24' C25' C26' 74(4) . . . . ? C24' C25' C26' C27' -61(3) . . . . ? C24' C25' C26' C28 157(3) . . . . ? C25' O21' C22' C23' -50(3) . . . . ? C25' O21' C22' C27' 54(2) . . . . ? C25' C26' C27' C22' -10(3) . . . . ? C25' C26' C27' C29 -109(3) . . . . ? C25' C26' C28 O28B -128(2) . . . . ? C25' C26' C28 O28A 60(3) . . . . ? C26' C27' C29 O29B 123(2) . . . . ? C26' C27' C29 O29A -73(2) . . . . ? C27' C22' C23' C24' -74(3) . . . . ? C27' C26' C28 O28B 110(4) . . . . ? C27' C26' C28 O28A -62(4) . . . . ? C28 C26 C27 C22 -118.7(8) . . . . ? C28 C26 C27 C29 0.3(12) . . . . ? C28 C26' C27' C22' 116(4) . . . . ? C28 C26' C27' C29 17(5) . . . . ? O31 C32 C33 C34 30.9(8) . . . . ? O31 C32 C37 C36 -34.0(7) . . . . ? O31 C32 C37 C39 88.8(7) . . . . ? O31 C35 C36 C37 37.7(7) . . . . ? O31 C35 C36 C38 -86.8(9) . . . . ? C32 O31 C35 C34 48.8(7) . . . . ? C32 O31 C35 C36 -61.9(6) . . . . ? C32 C33 C34 C35 0.4(9) . . . . ? C32 C37 C39 O39B -67.3(9) . . . . ? C32 C37 C39 O39A 114.0(8) . . . . ? C33 C32 C37 C36 72.4(7) . . . . ? C33 C32 C37 C39 -164.8(6) . . . . ? C33 C34 C35 O31 -31.3(8) . . . . ? C33 C34 C35 C36 74.9(9) . . . . ? C34 C35 C36 C37 -68.8(8) . . . . ? C34 C35 C36 C38 166.6(8) . . . . ? C35 O31 C32 C33 -49.0(7) . . . . ? C35 O31 C32 C37 59.2(6) . . . . ? C35 C36 C37 C32 -2.1(7) . . . . ? C35 C36 C37 C39 -117.7(7) . . . . ? C35 C36 C38 O38B -7.1(13) . . . . ? C35 C36 C38 O38A 176.0(7) . . . . ? C36 C37 C39 O39B 43.3(12) . . . . ? C36 C37 C39 O39A -135.4(8) . . . . ? C37 C32 C33 C34 -73.8(8) . . . . ? C37 C36 C38 O38B -123.6(10) . . . . ? C37 C36 C38 O38A 59.5(12) . . . . ? O31' C32' C33' C34' -43(4) . . . . ? O31' C32' C37' C36' 30(3) . . . . ? O31' C32' C37' C39 -81(3) . . . . ? O31' C35' C36' C37' -42(3) . . . . ? O31' C35' C36' C38 100(4) . . . . ? C32' O31' C35' C34' -42(3) . . . . ? C32' O31' C35' C36' 66(3) . . . . ? C32' C33' C34' C35' 15(4) . . . . ? C32' C37' C39 O39B 180.0(19) . . . . ? C32' C37' C39 O39A -17(3) . . . . ? C33' C32' C37' C36' -75(3) . . . . ? C33' C32' C37' C39 175(3) . . . . ? C33' C34' C35' O31' 17(4) . . . . ? C33' C34' C35' C36' -87(4) . . . . ? C34' C35' C36' C37' 65(3) . . . . ? C34' C35' C36' C38 -153(4) . . . . ? C35' O31' C32' C33' 52(3) . . . . ? C35' O31' C32' C37' -59(2) . . . . ? C35' C36' C37' C32' 7(3) . . . . ? C35' C36' C37' C39 117(3) . . . . ? C35' C36' C38 O38B 123(4) . . . . ? C35' C36' C38 O38A -63(5) . . . . ? C36' C37' C39 O39B 73(3) . . . . ? C36' C37' C39 O39A -124(3) . . . . ? C37' C32' C33' C34' 60(4) . . . . ? C37' C36' C38 O38B -104(5) . . . . ? C37' C36' C38 O38A 70(5) . . . . ? C38 C36 C37 C32 121.0(9) . . . . ? C38 C36 C37 C39 5.4(13) . . . . ? C38 C36' C37' C32' -134(5) . . . . ? C38 C36' C37' C39 -24(5) . . . . ? O41 C42 C43 C44 -30.4(7) . . . . ? O41 C42 C47 C46 38.3(6) . . . . ? O41 C42 C47 C49 -84.9(7) . . . . ? O41 C45 C46 C47 -33.5(6) . . . . ? O41 C45 C46 C48 90.0(6) . . . . ? C42 O41 C45 C44 -50.2(6) . . . . ? C42 O41 C45 C46 59.4(6) . . . . ? C42 C43 C44 C45 -1.2(8) . . . . ? C42 C47 C49 O49A 171.9(6) . . . . ? C42 C47 C49 O49B -10.3(9) . . . . ? C43 C42 C47 C46 -67.5(6) . . . . ? C43 C42 C47 C49 169.3(6) . . . . ? C43 C44 C45 O41 32.9(7) . . . . ? C43 C44 C45 C46 -73.5(7) . . . . ? C44 C45 C46 C47 73.1(6) . . . . ? C44 C45 C46 C48 -163.3(6) . . . . ? C45 O41 C42 C43 49.0(6) . . . . ? C45 O41 C42 C47 -61.1(6) . . . . ? C45 C46 C47 C42 -2.9(6) . . . . ? C45 C46 C47 C49 118.2(7) . . . . ? C45 C46 C48 O48A -56.4(8) . . . . ? C45 C46 C48 O48B 121.7(7) . . . . ? C46 C47 C49 O49A 57.0(8) . . . . ? C46 C47 C49 O49B -125.2(7) . . . . ? C47 C42 C43 C44 74.6(7) . . . . ? C47 C46 C48 O48A 56.4(9) . . . . ? C47 C46 C48 O48B -125.5(7) . . . . ? C48 C46 C47 C42 -122.2(7) . . . . ? C48 C46 C47 C49 -1.1(9) . . . . ? O51 C52 C53 C54 31.7(7) . . . . ? O51 C52 C57 C56 -39.4(6) . . . . ? O51 C52 C57 C59 84.2(6) . . . . ? O51 C55 C56 C57 34.2(6) . . . . ? O51 C55 C56 C58 -91.1(6) . . . . ? C52 O51 C55 C54 48.6(6) . . . . ? C52 O51 C55 C56 -60.2(6) . . . . ? C52 C53 C54 C55 -0.2(8) . . . . ? C52 C57 C59 O59A -172.3(5) . . . . ? C52 C57 C59 O59B 7.9(9) . . . . ? C53 C52 C57 C56 67.4(6) . . . . ? C53 C52 C57 C59 -169.0(5) . . . . ? C53 C54 C55 O51 -31.5(8) . . . . ? C53 C54 C55 C56 74.3(7) . . . . ? C54 C55 C56 C57 -72.5(6) . . . . ? C54 C55 C56 C58 162.2(6) . . . . ? C55 O51 C52 C53 -48.6(6) . . . . ? C55 O51 C52 C57 62.0(6) . . . . ? C55 C56 C57 C52 3.1(6) . . . . ? C55 C56 C57 C59 -119.2(6) . . . . ? C55 C56 C58 O58A 56.3(8) . . . . ? C55 C56 C58 O58B -119.9(7) . . . . ? C56 C57 C59 O59A -56.1(8) . . . . ? C56 C57 C59 O59B 124.1(7) . . . . ? C57 C52 C53 C54 -73.3(7) . . . . ? C57 C56 C58 O58A -57.2(9) . . . . ? C57 C56 C58 O58B 126.6(7) . . . . ? C58 C56 C57 C52 123.3(6) . . . . ? C58 C56 C57 C59 1.1(9) . . . . ? O61 C62 C63 C64 32.3(8) . . . . ? O61 C62 C67 C66 -34.4(7) . . . . ? O61 C62 C67 C69 87.2(7) . . . . ? O61 C65 C66 C67 38.0(6) . . . . ? O61 C65 C66 C68 -86.3(7) . . . . ? C62 O61 C65 C64 49.6(6) . . . . ? C62 O61 C65 C66 -61.1(6) . . . . ? C62 C63 C64 C65 0.1(8) . . . . ? C62 C67 C69 O69B -88.4(10) . . . . ? C62 C67 C69 O69A 88.2(8) . . . . ? C62 C67 C69 O69C 133(2) . . . . ? C62 C67 C69 O69D -51(2) . . . . ? C63 C62 C67 C66 73.6(7) . . . . ? C63 C62 C67 C69 -164.9(6) . . . . ? C63 C64 C65 O61 -31.6(7) . . . . ? C63 C64 C65 C66 74.2(8) . . . . ? C64 C65 C66 C67 -68.5(6) . . . . ? C64 C65 C66 C68 167.2(6) . . . . ? C65 O61 C62 C63 -50.1(6) . . . . ? C65 O61 C62 C67 59.6(6) . . . . ? C65 C66 C67 C62 -2.5(6) . . . . ? C65 C66 C67 C69 -119.7(7) . . . . ? C65 C66 C68 O68B 1.8(10) . . . . ? C65 C66 C68 O68A -174.7(6) . . . . ? C66 C67 C69 O69B 23.0(12) . . . . ? C66 C67 C69 O69A -160.4(7) . . . . ? C66 C67 C69 O69C -116(2) . . . . ? C66 C67 C69 O69D 60(2) . . . . ? C67 C62 C63 C64 -75.0(7) . . . . ? C67 C66 C68 O68B -112.6(8) . . . . ? C67 C66 C68 O68A 70.9(9) . . . . ? C68 C66 C67 C62 118.1(7) . . . . ? C68 C66 C67 C69 0.9(10) . . . . ? O71 C72 C73 C74 31.4(7) . . . . ? O71 C72 C77 C76 -38.7(6) . . . . ? O71 C72 C77 C79 85.1(6) . . . . ? O71 C75 C76 C77 35.3(6) . . . . ? O71 C75 C76 C78 -89.1(7) . . . . ? C72 O71 C75 C74 49.0(6) . . . . ? C72 O71 C75 C76 -60.7(6) . . . . ? C72 C73 C74 C75 -0.1(8) . . . . ? C72 C77 C79 O79B 0.1(9) . . . . ? C72 C77 C79 O79A 175.1(6) . . . . ? C73 C72 C77 C76 68.2(6) . . . . ? C73 C72 C77 C79 -168.0(6) . . . . ? C73 C74 C75 O71 -31.9(8) . . . . ? C73 C74 C75 C76 74.4(8) . . . . ? C74 C75 C76 C77 -72.9(7) . . . . ? C74 C75 C76 C78 162.8(6) . . . . ? C75 O71 C72 C73 -48.5(6) . . . . ? C75 O71 C72 C77 61.9(6) . . . . ? C75 C76 C77 C72 2.3(6) . . . . ? C75 C76 C77 C79 -118.7(6) . . . . ? C75 C76 C78 O78B 87.4(10) . . . . ? C75 C76 C78 O78A -85.8(8) . . . . ? C75 C76 C78 O78C -133.5(18) . . . . ? C75 C76 C78 O78D 49(2) . . . . ? C76 C77 C79 O79B 115.4(7) . . . . ? C76 C77 C79 O79A -69.6(8) . . . . ? C77 C72 C73 C74 -73.3(8) . . . . ? C77 C76 C78 O78B -25.5(11) . . . . ? C77 C76 C78 O78A 161.3(6) . . . . ? C77 C76 C78 O78C 113.6(18) . . . . ? C77 C76 C78 O78D -64(2) . . . . ? C78 C76 C77 C72 120.6(7) . . . . ? C78 C76 C77 C79 -0.5(9) . . . . ? _shelx_res_file ; dalecorrectedmcg1797a_a.res created by SHELXL-2014/7 TITL mcg1797a_a.res in P2(1) REM Old TITL mcg1797a in P2(1)/m REM SHELXT solution in P2(1) REM R1 0.198, Rweak 0.012, Alpha 0.018, Orientation as input REM Flack x = 0.392 ( 0.667 ) from Parsons' quotients REM Formula found by SHELXT: C69 O35 rem omit -2 51 rem EXTI 0.000670 CELL 0.71073 9.2321 18.7683 18.8764 90 93.723 90 ZERR 16 0.0019 0.0037 0.0038 0 0.03 0 LATT -1 SYMM -X,0.5+Y,-Z SFAC C H O UNIT 128 128 80 EQIV $1 1-X,0.5+Y,1-Z EQIV $2 -1+X,+Y,+Z EQIV $3 +X,+Y,1+Z EQIV $4 1-X,-0.5+Y,1-Z EQIV $5 +X,+Y,-1+Z EQIV $6 1+X,+Y,+Z SADI 0.01 C6 C8 C6' C8 C7 C9 C7' C9 SADI 0.01 C16 C18 C16' C18 C17 C19 C17' C19 SADI C26 C28 C26' C28 C27 C29 C27' C29 SADI 0.01 C36 C38 C36' C38 C37 C39 C37' C39 SADI 0.01 C69 O69A C69 O69C SADI 0.01 C69 O69B C69 O69D SADI 0.01 O69A O69B O69C O69D SADI 0.01 C78 O78A C78 O78C SADI 0.01 C78 O78B C78 O78B SADI 0.01 O78A O78B O78C O78D FLAT C67 C69 O69C O69D FLAT C76 C78 O78C O78D RIGU EADP C6 C6' EADP C7 C7' EADP C16 C16' EADP C17 C17' EADP C27 C26' EADP C27 C27' EADP C36 C36' EADP C37 C37' L.S. 10 PLAN -40 SIZE 0.13 0.19 0.28 TEMP -83 HTAB O8A O19B HTAB O9A O28B_$4 HTAB O18A O39B_$5 HTAB O19A O8B HTAB O28A O9B_$1 HTAB O29A O38B_$1 HTAB O38A O29B_$4 HTAB O39A O18B_$3 HTAB O48A O58B HTAB O49A O59B_$2 HTAB O58A O48B HTAB O59A O49B_$6 HTAB O68A O79B_$6 HTAB O69A O78B HTAB O78A O69B HTAB O69C O78D HTAB O78C O69D HTAB O79A O68B_$2 BOND $H LIST 6 bond $h conf fmap 2 acta SHEL 11 0 OMIT 1 0 0 REM REM REM WGHT 0.067200 1.690100 FVAR 0.22590 0.82466 0.85409 0.84009 PART 1 O1 3 0.024877 0.683673 0.400945 21.00000 0.01371 0.01698 = 0.04074 -0.00099 0.00337 -0.00262 C2 1 0.125894 0.712043 0.452824 21.00000 0.02293 0.01323 = 0.02285 0.00094 0.00612 0.00540 AFIX 13 H2 2 0.093760 0.711278 0.502399 21.00000 -1.20000 AFIX 0 C3 1 0.155843 0.785588 0.424020 21.00000 0.02124 0.00883 = 0.02237 -0.00190 0.00183 0.00037 AFIX 43 H3 2 0.178907 0.827573 0.450510 21.00000 -1.20000 AFIX 0 C4 1 0.143043 0.778872 0.354214 21.00000 0.03269 0.01181 = 0.02203 0.00322 -0.00317 -0.00007 AFIX 43 H4 2 0.155417 0.814877 0.319753 21.00000 -1.20000 AFIX 0 C5 1 0.104376 0.701361 0.341013 21.00000 0.03040 0.01550 = 0.02380 -0.00188 -0.01091 0.00185 AFIX 13 H5 2 0.053568 0.690951 0.293743 21.00000 -1.20000 AFIX 0 C6 1 0.255026 0.660025 0.357232 21.00000 0.01918 0.01976 = 0.03071 -0.00037 0.00506 -0.00282 AFIX 13 H6 2 0.336902 0.688708 0.339923 21.00000 -1.20000 AFIX 0 C7 1 0.255677 0.664803 0.440360 21.00000 0.01339 0.01637 = 0.03056 -0.00745 0.00881 -0.00094 AFIX 13 H7 2 0.345518 0.690754 0.457983 21.00000 -1.20000 AFIX 0 SAME 0.02 0.04 O1 > C7 PART 0 PART 2 O1' 3 0.471678 0.692455 0.382116 -21.00000 0.03042 0.03162 = 0.06586 -0.00597 0.00813 -0.00984 C2' 1 0.395536 0.717695 0.437554 -21.00000 0.03132 0.02864 = 0.05401 -0.00294 0.00529 -0.01530 AFIX 13 H2' 2 0.453752 0.720590 0.484023 -21.00000 -1.20000 AFIX 0 C3' 1 0.335806 0.788988 0.410122 -21.00000 0.07568 0.03529 = 0.06064 -0.00033 0.01455 -0.00024 AFIX 43 H3' 2 0.316348 0.829855 0.437640 -21.00000 -1.20000 AFIX 0 C4' 1 0.316281 0.782496 0.339588 -21.00000 0.05722 0.03716 = 0.05935 -0.00344 0.01372 0.00442 AFIX 43 H4' 2 0.279665 0.816794 0.306013 -21.00000 -1.20000 AFIX 0 C5' 1 0.366580 0.707402 0.326290 -21.00000 0.03509 0.03152 = 0.05375 -0.00491 0.01405 -0.00760 AFIX 13 H5' 2 0.396208 0.697292 0.277268 -21.00000 -1.20000 AFIX 0 C6' 1 0.234105 0.660796 0.352032 -21.00000 0.01918 0.01976 = 0.03071 -0.00037 0.00506 -0.00282 AFIX 13 H6' 2 0.136221 0.681566 0.339033 -21.00000 -1.20000 AFIX 0 C7' 1 0.277060 0.660479 0.434593 -21.00000 0.01339 0.01637 = 0.03056 -0.00745 0.00881 -0.00094 AFIX 13 H7' 2 0.195359 0.690174 0.450568 -21.00000 -1.20000 AFIX 0 PART 0 C8 1 0.254182 0.587341 0.324837 11.00000 0.02298 0.02750 = 0.03461 0.00010 0.00858 -0.00406 O8A 3 0.150847 0.543959 0.338099 11.00000 0.02873 0.02440 = 0.04477 -0.00698 0.01049 -0.00809 AFIX 83 H8A 2 0.161716 0.505516 0.316281 11.00000 -1.50000 AFIX 0 O8B 3 0.352877 0.570534 0.286373 11.00000 0.03389 0.03762 = 0.05331 -0.02025 0.02390 -0.01256 C9 1 0.252920 0.595509 0.477651 11.00000 0.02094 0.01839 = 0.03108 -0.00584 0.00122 -0.00044 O9A 3 0.360840 0.552465 0.463961 11.00000 0.02897 0.02253 = 0.04827 0.00817 0.01462 0.01220 AFIX 83 H9A 2 0.352922 0.514158 0.486396 11.00000 -1.50000 AFIX 0 O9B 3 0.161607 0.580266 0.519983 11.00000 0.02967 0.03899 = 0.03781 0.01299 0.01745 0.01174 PART 1 O11 3 0.044918 0.317063 0.140823 31.00000 0.01952 0.01827 = 0.07859 -0.00500 -0.00704 -0.00005 C12 1 0.141453 0.290075 0.197859 31.00000 0.03198 0.01845 = 0.03567 -0.00774 0.00824 -0.00470 AFIX 13 H12 2 0.100464 0.290890 0.245605 31.00000 -1.20000 AFIX 0 C13 1 0.178556 0.216269 0.171566 31.00000 0.02854 0.01571 = 0.02939 -0.00267 -0.00365 -0.00526 AFIX 43 H13 2 0.198131 0.174609 0.199130 31.00000 -1.20000 AFIX 0 C14 1 0.177601 0.222729 0.102804 31.00000 0.05286 0.01702 = 0.02531 -0.00461 -0.00833 0.00048 AFIX 43 H14 2 0.197328 0.186491 0.069637 31.00000 -1.20000 AFIX 0 C15 1 0.138737 0.299588 0.086412 31.00000 0.04340 0.01959 = 0.03127 0.00170 -0.01837 -0.00282 AFIX 13 H15 2 0.097899 0.308735 0.036881 31.00000 -1.20000 AFIX 0 C16 1 0.278070 0.343176 0.109522 31.00000 0.02523 0.01539 = 0.01614 0.00405 -0.00034 0.00673 AFIX 13 H16 2 0.366016 0.318480 0.093308 31.00000 -1.20000 AFIX 0 C17 1 0.273189 0.336216 0.191787 31.00000 0.02570 0.01874 = 0.01759 0.00581 -0.00119 0.00351 AFIX 13 H17 2 0.361581 0.310489 0.211658 31.00000 -1.20000 AFIX 0 SAME 0.02 0.04 O11 > C17 PART 0 PART 2 O11' 3 0.448391 0.326747 0.134725 -31.00000 0.04313 0.05040 = 0.04849 0.00242 0.00479 0.00915 C12' 1 0.358034 0.296045 0.186291 -31.00000 0.04158 0.03729 = 0.04011 0.00541 -0.00199 0.01832 AFIX 13 H12' 2 0.403827 0.292926 0.235676 -31.00000 -1.20000 AFIX 0 C13' 1 0.307844 0.225442 0.153808 -31.00000 0.05661 0.03611 = 0.05339 0.00031 0.00384 0.01636 AFIX 43 H13' 2 0.264466 0.187328 0.177897 -31.00000 -1.20000 AFIX 0 C14' 1 0.334731 0.226623 0.087763 -31.00000 0.06877 0.03987 = 0.05409 0.00307 0.00382 0.01475 AFIX 43 H14' 2 0.338147 0.187852 0.055559 -31.00000 -1.20000 AFIX 0 C15' 1 0.359649 0.305247 0.073993 -31.00000 0.04695 0.04055 = 0.04428 0.00165 0.00740 0.01588 AFIX 13 H15' 2 0.395326 0.317900 0.026701 -31.00000 -1.20000 AFIX 0 C16' 1 0.214999 0.341631 0.093916 -31.00000 0.02523 0.01539 = 0.01614 0.00405 -0.00034 0.00673 AFIX 13 H16' 2 0.121305 0.323450 0.071225 -31.00000 -1.20000 AFIX 0 C17' 1 0.232204 0.346132 0.176978 -31.00000 0.02570 0.01874 = 0.01759 0.00581 -0.00119 0.00351 AFIX 13 H17' 2 0.147245 0.319831 0.194364 -31.00000 -1.20000 AFIX 0 PART 0 C18 1 0.263375 0.416621 0.075443 11.00000 0.03656 0.02323 = 0.02822 0.00330 0.01007 0.00250 O18B 3 0.165412 0.459872 0.088083 11.00000 0.05961 0.02959 = 0.04715 0.01444 0.03315 0.01432 O18A 3 0.354142 0.429104 0.030446 11.00000 0.08477 0.06435 = 0.09957 0.05711 0.07023 0.04011 AFIX 83 H18A 2 0.336488 0.468986 0.011622 11.00000 -1.50000 AFIX 0 C19 1 0.260836 0.407942 0.228841 11.00000 0.03476 0.02116 = 0.02422 -0.00377 0.00523 -0.00013 O19B 3 0.161775 0.419833 0.268705 11.00000 0.03927 0.02094 = 0.03785 -0.00728 0.01510 -0.00601 O19A 3 0.366423 0.450273 0.219546 11.00000 0.03219 0.02703 = 0.05910 -0.01045 0.01515 -0.00519 AFIX 83 H19A 2 0.348843 0.490285 0.236986 11.00000 -1.50000 AFIX 0 PART 1 O21 3 0.530204 0.808225 0.365313 21.00000 0.01796 0.02382 = 0.05505 0.00361 0.00111 0.00171 C22 1 0.623334 0.781501 0.312691 21.00000 0.03301 0.02780 = 0.02980 0.00081 -0.00527 -0.00027 AFIX 13 H22 2 0.579315 0.782250 0.262875 21.00000 -1.20000 AFIX 0 C23 1 0.662499 0.707473 0.341270 21.00000 0.03638 0.01726 = 0.03678 -0.00340 -0.00654 0.00269 AFIX 43 H23 2 0.680838 0.665674 0.314918 21.00000 -1.20000 AFIX 0 C24 1 0.665110 0.714561 0.410116 21.00000 0.03022 0.02071 = 0.03672 -0.00124 -0.00269 -0.00171 AFIX 43 H24 2 0.686565 0.678298 0.444313 21.00000 -1.20000 AFIX 0 C25 1 0.627833 0.790817 0.425228 21.00000 0.03089 0.02141 = 0.02842 -0.00241 0.00697 0.00131 AFIX 13 H25 2 0.589629 0.799767 0.472797 21.00000 -1.20000 AFIX 0 C26 1 0.763002 0.835423 0.408352 21.00000 0.02868 0.01794 = 0.02795 -0.00299 0.00134 0.00173 AFIX 13 H26 2 0.852273 0.813141 0.431619 21.00000 -1.20000 AFIX 0 C27 1 0.766054 0.828473 0.325570 21.00000 0.01555 0.02144 = 0.03070 -0.00333 0.00007 -0.00024 AFIX 13 H27 2 0.852786 0.800132 0.313471 21.00000 -1.20000 AFIX 0 SAME 0.02 0.04 O21 > C27 PART 0 PART 2 O21' 3 0.973918 0.823805 0.353041 -21.00000 0.04243 0.05556 = 0.07389 -0.00471 0.00022 0.00062 C22' 1 0.876874 0.791100 0.297212 -21.00000 0.03027 0.04495 = 0.06637 -0.00567 0.00554 0.00924 AFIX 13 H22' 2 0.907492 0.795063 0.247512 -21.00000 -1.20000 AFIX 0 C23' 1 0.856381 0.715278 0.325584 -21.00000 0.04707 0.04128 = 0.07335 -0.00093 0.00258 0.00965 AFIX 43 H23' 2 0.840427 0.672255 0.299733 -21.00000 -1.20000 AFIX 0 C24' 1 0.866323 0.724837 0.393377 -21.00000 0.05944 0.04919 = 0.07569 -0.00358 0.00470 0.00788 AFIX 43 H24' 2 0.859687 0.688428 0.427978 -21.00000 -1.20000 AFIX 0 C25' 1 0.890274 0.803339 0.409189 -21.00000 0.03260 0.04924 = 0.06244 -0.00314 -0.00719 0.01367 AFIX 13 H25' 2 0.936807 0.813401 0.457471 -21.00000 -1.20000 AFIX 0 C26' 1 0.747410 0.843215 0.392223 -21.00000 0.01555 0.02144 = 0.03070 -0.00333 0.00007 -0.00024 AFIX 13 H26' 2 0.672756 0.813328 0.414264 -21.00000 -1.20000 AFIX 0 C27' 1 0.728323 0.825204 0.312048 -21.00000 0.01555 0.02144 = 0.03070 -0.00333 0.00007 -0.00024 AFIX 13 H27' 2 0.638046 0.799572 0.294493 -21.00000 -1.20000 AFIX 0 PART 0 C28 1 0.749846 0.911143 0.433897 11.00000 0.02416 0.02220 = 0.02873 -0.00297 0.00279 -0.00218 O28B 3 0.653427 0.929227 0.472126 11.00000 0.04293 0.03266 = 0.07029 -0.02107 0.03434 -0.01356 O28A 3 0.856406 0.953007 0.418559 11.00000 0.03704 0.02620 = 0.03814 -0.01103 0.01587 -0.01097 AFIX 83 H28A 2 0.847866 0.992406 0.438982 11.00000 -1.50000 AFIX 0 C29 1 0.756622 0.895860 0.281582 11.00000 0.01733 0.03253 = 0.03873 -0.00653 0.00478 -0.00115 O29B 3 0.850625 0.908936 0.240035 11.00000 0.02803 0.03206 = 0.04693 -0.00002 0.01384 0.00153 O29A 3 0.648261 0.937538 0.290249 11.00000 0.03002 0.02603 = 0.05151 0.00326 0.01018 0.00517 AFIX 83 H29A 2 0.662766 0.977007 0.270958 11.00000 -1.50000 AFIX 0 PART 1 O31 3 0.447743 0.684625 0.888757 31.00000 0.02257 0.02637 = 0.06980 -0.00007 0.00276 0.00798 C32 1 0.353654 0.710055 0.939556 31.00000 0.04366 0.02849 = 0.03268 0.00328 -0.00719 0.00823 AFIX 13 H32 2 0.394863 0.710190 0.989875 31.00000 -1.20000 AFIX 0 C33 1 0.307267 0.781754 0.909921 31.00000 0.05033 0.02487 = 0.02933 0.00240 0.00295 0.01446 AFIX 43 H33 2 0.282754 0.822909 0.935888 31.00000 -1.20000 AFIX 0 C34 1 0.307916 0.775221 0.839891 31.00000 0.03751 0.02000 = 0.03175 0.00608 0.00603 0.00135 AFIX 43 H34 2 0.284514 0.810702 0.805120 31.00000 -1.20000 AFIX 0 C35 1 0.354312 0.698509 0.827286 31.00000 0.03460 0.02548 = 0.03936 -0.00032 0.01519 0.00018 AFIX 13 H35 2 0.398791 0.690111 0.781101 31.00000 -1.20000 AFIX 0 C36 1 0.224003 0.650525 0.840576 31.00000 0.03609 0.03072 = 0.02809 0.00574 0.01118 0.00283 AFIX 13 H36 2 0.134807 0.671851 0.816253 31.00000 -1.20000 AFIX 0 C37 1 0.214907 0.658659 0.923137 31.00000 0.02937 0.02865 = 0.03087 0.00292 0.01007 0.01180 AFIX 13 H37 2 0.123255 0.683513 0.934189 31.00000 -1.20000 AFIX 0 SAME 0.02 0.04 O31 > C37 PART 0 PART 2 O31' 3 0.033839 0.687985 0.895829 -31.00000 0.05262 0.04465 = 0.05312 0.00026 0.00604 0.01752 C32' 1 0.137705 0.713609 0.948154 -31.00000 0.04492 0.03923 = 0.03911 0.00376 0.01025 0.02028 AFIX 13 H32' 2 0.107288 0.712251 0.998024 -31.00000 -1.20000 AFIX 0 C33' 1 0.167192 0.786094 0.919814 -31.00000 0.05434 0.04149 = 0.02345 0.00361 0.00776 0.01669 AFIX 43 H33' 2 0.177265 0.829757 0.945114 -31.00000 -1.20000 AFIX 0 C34' 1 0.176082 0.774717 0.849770 -31.00000 0.07802 0.04592 = 0.02742 -0.00035 0.00797 0.00890 AFIX 43 H34' 2 0.215030 0.805927 0.816242 -31.00000 -1.20000 AFIX 0 C35' 1 0.110362 0.701105 0.835700 -31.00000 0.05412 0.04546 = 0.04084 -0.00087 -0.00004 0.01716 AFIX 13 H35' 2 0.053278 0.695488 0.789175 -31.00000 -1.20000 AFIX 0 C36' 1 0.236740 0.647445 0.849750 -31.00000 0.03609 0.03072 = 0.02809 0.00574 0.01118 0.00283 AFIX 13 H36' 2 0.319349 0.672712 0.828924 -31.00000 -1.20000 AFIX 0 C37' 1 0.268065 0.661666 0.931698 -31.00000 0.02937 0.02865 = 0.03087 0.00292 0.01007 0.01180 AFIX 13 H37' 2 0.366690 0.681571 0.944726 -31.00000 -1.20000 AFIX 0 PART 0 C38 1 0.240327 0.576219 0.814448 11.00000 0.03665 0.03418 = 0.03850 0.00064 0.01821 -0.00357 O38B 3 0.342221 0.558456 0.779298 11.00000 0.04397 0.03394 = 0.06737 -0.01819 0.03292 -0.01525 O38A 3 0.137009 0.533191 0.828527 11.00000 0.03748 0.03892 = 0.06782 0.00104 0.02668 -0.00343 AFIX 83 H38A 2 0.154398 0.492533 0.812525 11.00000 -1.50000 AFIX 0 C39 1 0.236836 0.592990 0.967646 11.00000 0.03131 0.03125 = 0.03040 -0.00022 0.01448 0.00966 O39B 3 0.337109 0.548727 0.956644 11.00000 0.06230 0.04908 = 0.06077 0.02508 0.04213 0.03510 O39A 3 0.149701 0.582543 1.016042 11.00000 0.03943 0.05632 = 0.04452 0.01738 0.02346 0.01661 AFIX 83 H39A 2 0.166400 0.542541 1.034793 11.00000 -1.50000 AFIX 0 O41 3 0.218540 0.935004 0.522264 11.00000 0.05024 0.02761 = 0.02224 -0.00569 0.00784 -0.00059 C42 1 0.116729 0.960343 0.569666 11.00000 0.02610 0.02515 = 0.02630 -0.00013 0.00158 -0.00253 AFIX 13 H42 2 0.012905 0.958771 0.550992 11.00000 -1.20000 AFIX 0 C43 1 0.176075 1.034756 0.587603 11.00000 0.02927 0.01375 = 0.03004 -0.00059 0.00413 0.00192 AFIX 43 H43 2 0.121921 1.075680 0.599249 11.00000 -1.20000 AFIX 0 C44 1 0.316135 1.030442 0.583617 11.00000 0.03115 0.02164 = 0.03730 -0.00177 0.01312 -0.00442 AFIX 43 H44 2 0.385496 1.067555 0.590846 11.00000 -1.20000 AFIX 0 C45 1 0.344559 0.953005 0.564859 11.00000 0.02797 0.02500 = 0.03751 0.00073 0.01238 0.00137 AFIX 13 H45 2 0.438138 0.944228 0.542444 11.00000 -1.20000 AFIX 0 C46 1 0.323600 0.908858 0.634404 11.00000 0.01867 0.02291 = 0.02668 -0.00574 0.00177 -0.00015 AFIX 13 H46 2 0.368811 0.934853 0.676480 11.00000 -1.20000 AFIX 0 C47 1 0.154709 0.912488 0.635070 11.00000 0.01968 0.01745 = 0.02338 -0.00211 0.00414 -0.00209 AFIX 13 H47 2 0.127536 0.937614 0.679000 11.00000 -1.20000 AFIX 0 C48 1 0.390216 0.835981 0.629855 11.00000 0.02036 0.02085 = 0.02681 -0.00764 -0.00357 0.00188 O48A 3 0.350661 0.795783 0.578993 11.00000 0.04050 0.03062 = 0.04810 -0.01902 -0.01504 0.01650 AFIX 83 H48A 2 0.402145 0.758845 0.580536 11.00000 -1.50000 AFIX 0 O48B 3 0.486365 0.818588 0.676262 11.00000 0.06133 0.03750 = 0.05240 -0.02102 -0.03010 0.02621 C49 1 0.078980 0.842233 0.629663 11.00000 0.02892 0.02218 = 0.02467 0.00226 0.00550 -0.00291 O49A 3 0.121244 0.796561 0.679254 11.00000 0.04792 0.02305 = 0.03453 0.00688 -0.00700 -0.01306 AFIX 83 H49A 2 0.081205 0.757028 0.670677 11.00000 -1.50000 AFIX 0 O49B 3 -0.017754 0.829186 0.584057 11.00000 0.03894 0.03130 = 0.03274 0.00330 -0.00782 -0.01532 O51 3 0.775267 0.559967 0.727366 11.00000 0.04784 0.01943 = 0.02094 0.00399 0.00572 0.00157 C52 1 0.876651 0.537254 0.677175 11.00000 0.02080 0.01485 = 0.03471 0.00347 -0.00581 0.00136 AFIX 13 H52 2 0.981162 0.540668 0.694396 11.00000 -1.20000 AFIX 0 C53 1 0.825125 0.463835 0.658429 11.00000 0.02368 0.01561 = 0.04108 0.00188 0.00375 0.00250 AFIX 43 H53 2 0.882829 0.424468 0.645851 11.00000 -1.20000 AFIX 0 C54 1 0.683477 0.464760 0.662878 11.00000 0.02384 0.01675 = 0.04943 0.00460 0.00173 -0.00361 AFIX 43 H54 2 0.617742 0.426345 0.654104 11.00000 -1.20000 AFIX 0 C55 1 0.647676 0.539102 0.684680 11.00000 0.02216 0.02820 = 0.04085 0.00239 0.01551 0.00039 AFIX 13 H55 2 0.554077 0.544398 0.708013 11.00000 -1.20000 AFIX 0 C56 1 0.661996 0.586226 0.615941 11.00000 0.01730 0.01325 = 0.02791 -0.00837 0.00093 -0.00035 AFIX 13 H56 2 0.618844 0.559909 0.573605 11.00000 -1.20000 AFIX 0 C57 1 0.831242 0.586067 0.614221 11.00000 0.01948 0.01554 = 0.01791 -0.00425 0.00709 -0.00099 AFIX 13 H57 2 0.858591 0.562928 0.569275 11.00000 -1.20000 AFIX 0 C58 1 0.586393 0.656015 0.621805 11.00000 0.02395 0.01844 = 0.02493 -0.00468 0.00057 0.00339 O58A 3 0.624194 0.694954 0.674835 11.00000 0.04584 0.02308 = 0.04550 -0.01532 -0.01516 0.01553 AFIX 83 H58A 2 0.575714 0.732856 0.672820 11.00000 -1.50000 AFIX 0 O58B 3 0.486778 0.671927 0.578345 11.00000 0.04684 0.05039 = 0.06258 -0.02894 -0.03204 0.02719 C59 1 0.900831 0.658416 0.620211 11.00000 0.02307 0.01410 = 0.01973 0.00098 0.00467 -0.00099 O59A 3 0.852503 0.704380 0.572414 11.00000 0.04591 0.02568 = 0.03763 0.01202 -0.00766 -0.01195 AFIX 83 H59A 2 0.898196 0.742873 0.578124 11.00000 -1.50000 AFIX 0 O59B 3 0.997039 0.672128 0.667307 11.00000 0.03814 0.02630 = 0.03817 0.00682 -0.00740 -0.01565 O61 3 0.767152 0.437791 0.978715 11.00000 0.06447 0.03050 = 0.02764 0.00391 0.00736 0.00450 C62 1 0.645819 0.459733 0.935884 11.00000 0.03098 0.02746 = 0.04772 -0.00609 0.01501 -0.00334 AFIX 13 H62 2 0.551128 0.454722 0.958293 11.00000 -1.20000 AFIX 0 C63 1 0.684119 0.536167 0.915469 11.00000 0.03652 0.02126 = 0.03926 -0.00314 0.01054 0.00003 AFIX 43 H63 2 0.620377 0.575413 0.906929 11.00000 -1.20000 AFIX 0 C64 1 0.825988 0.534616 0.912560 11.00000 0.03213 0.01488 = 0.03739 -0.00512 0.00365 -0.00433 AFIX 43 H64 2 0.887191 0.573145 0.901348 11.00000 -1.20000 AFIX 0 C65 1 0.872279 0.458762 0.930750 11.00000 0.02962 0.02462 = 0.03356 -0.00107 0.00186 0.00590 AFIX 13 H65 2 0.975542 0.453463 0.949483 11.00000 -1.20000 AFIX 0 C66 1 0.827715 0.411402 0.865067 11.00000 0.02984 0.01967 = 0.02673 0.00123 0.00118 0.00476 AFIX 13 H66 2 0.857280 0.435553 0.821043 11.00000 -1.20000 AFIX 0 C67 1 0.659120 0.413940 0.866810 11.00000 0.03041 0.02435 = 0.03049 0.00456 0.00211 -0.00509 AFIX 13 H67 2 0.615179 0.439715 0.824307 11.00000 -1.20000 AFIX 0 C68 1 0.897431 0.339242 0.870817 11.00000 0.03758 0.02870 = 0.02997 -0.00557 0.00179 0.00377 O68B 3 0.975210 0.320338 0.921282 11.00000 0.05599 0.02947 = 0.03587 -0.00977 -0.01700 0.01602 O68A 3 0.872257 0.300415 0.814470 11.00000 0.08837 0.03276 = 0.02788 -0.01141 -0.01618 0.02731 AFIX 83 H68A 2 0.912725 0.260599 0.820541 11.00000 -1.50000 AFIX 0 C69 1 0.586053 0.343166 0.875265 11.00000 0.03575 0.03129 = 0.02836 0.00463 -0.00308 -0.00946 PART 1 O69B 3 0.643194 0.288193 0.901486 41.00000 0.04018 0.02767 = 0.07191 0.01859 -0.01300 -0.01082 O69A 3 0.445463 0.345888 0.854485 41.00000 0.03283 0.03159 = 0.06537 0.01456 -0.01049 -0.01259 AFIX 83 H69A 2 0.411052 0.304443 0.853015 41.00000 -1.50000 AFIX 0 PART 0 PART 2 O69C 3 0.496097 0.321774 0.821092 -41.00000 -1.00000 AFIX 83 H69C 2 0.489774 0.277129 0.821463 -41.00000 -1.50000 AFIX 0 O69D 3 0.612924 0.304127 0.927816 -41.00000 -1.00000 PART 0 O71 3 0.210224 0.063846 0.769757 11.00000 0.05456 0.02185 = 0.01976 -0.00580 0.00318 -0.00465 C72 1 0.108392 0.037368 0.818513 11.00000 0.03129 0.02072 = 0.02814 -0.00813 -0.00180 -0.00338 AFIX 13 H72 2 0.004039 0.039943 0.800841 11.00000 -1.20000 AFIX 0 C73 1 0.164019 -0.036364 0.835179 11.00000 0.02919 0.02152 = 0.03817 -0.00349 0.00474 -0.00389 AFIX 43 H73 2 0.108663 -0.077111 0.846135 11.00000 -1.20000 AFIX 0 C74 1 0.308094 -0.032512 0.831329 11.00000 0.03423 0.01679 = 0.05580 -0.00260 0.00812 -0.00052 AFIX 43 H74 2 0.377008 -0.069760 0.839001 11.00000 -1.20000 AFIX 0 C75 1 0.336721 0.043341 0.812291 11.00000 0.03886 0.02604 = 0.04645 -0.00080 0.02170 -0.00566 AFIX 13 H75 2 0.430420 0.051486 0.789777 11.00000 -1.20000 AFIX 0 C76 1 0.317779 0.087978 0.882037 11.00000 0.02906 0.01550 = 0.02525 0.00373 -0.00132 -0.00208 AFIX 13 H76 2 0.364210 0.062184 0.923949 11.00000 -1.20000 AFIX 0 C77 1 0.150538 0.085004 0.884305 11.00000 0.02870 0.01887 = 0.01606 0.00088 0.00097 -0.00372 AFIX 13 H77 2 0.124996 0.059636 0.928382 11.00000 -1.20000 AFIX 0 C78 1 0.387043 0.159233 0.875277 11.00000 0.03542 0.02748 = 0.03197 0.00144 -0.00380 -0.01086 PART 1 O78B 3 0.327536 0.212078 0.848562 41.00000 0.03657 0.02597 = 0.07300 0.01838 0.00439 -0.01117 O78A 3 0.526698 0.156973 0.894763 41.00000 0.03234 0.03079 = 0.06795 0.01203 -0.00844 -0.01434 AFIX 83 H78A 2 0.563918 0.197133 0.888473 41.00000 -1.50000 AFIX 0 PART 0 PART 2 O78C 3 0.470452 0.179409 0.931401 -41.00000 -1.00000 AFIX 83 H78C 2 0.496465 0.221872 0.926180 -41.00000 -1.50000 AFIX 0 O78D 3 0.365660 0.197610 0.823729 -41.00000 -1.00000 PART 0 C79 1 0.073423 0.156093 0.879963 11.00000 0.03166 0.01712 = 0.01633 0.00305 0.00385 0.00088 O79B 3 -0.011328 0.173087 0.830547 11.00000 0.06157 0.02760 = 0.03109 -0.00937 -0.01469 0.01434 O79A 3 0.098918 0.194243 0.936905 11.00000 0.05729 0.02388 = 0.02992 -0.00930 -0.00911 0.00810 AFIX 83 H79A 2 0.059697 0.234390 0.931131 11.00000 -1.50000 AFIX 0 HKLF 4 REM mcg1797a_a.res in P2(1) REM R1 = 0.0584 for 7838 Fo > 4sig(Fo) and 0.1096 for all 12483 data REM 1156 parameters refined using 1296 restraints END WGHT 0.0673 1.6984 REM Highest difference peak 0.328, deepest hole -0.292, 1-sigma level 0.057 Q1 1 0.5445 0.8511 0.6297 11.00000 0.05 0.33 Q2 1 0.4546 0.6456 0.6194 11.00000 0.05 0.31 Q3 1 0.7312 0.9288 0.5186 11.00000 0.05 0.27 Q4 1 0.2448 0.0881 0.8891 11.00000 0.05 0.26 Q5 1 0.2393 0.9073 0.6386 11.00000 0.05 0.25 Q6 1 0.0366 0.7057 0.6725 11.00000 0.05 0.25 Q7 1 0.3909 -0.0603 0.8749 11.00000 0.05 0.24 Q8 1 0.6421 0.8219 0.6238 11.00000 0.05 0.23 Q9 1 0.3358 0.9284 0.6002 11.00000 0.05 0.23 Q10 1 0.4273 1.0545 0.6268 11.00000 0.05 0.23 Q11 1 0.1572 0.9426 0.1089 11.00000 0.05 0.22 Q12 1 0.6417 0.5662 0.6473 11.00000 0.05 0.22 Q13 1 0.0476 0.6938 0.5482 11.00000 0.05 0.22 Q14 1 0.2725 0.5826 0.2627 11.00000 0.05 0.22 Q15 1 0.0193 0.7117 0.9692 11.00000 0.05 0.22 Q16 1 0.2831 0.8103 0.4618 11.00000 0.05 0.22 Q17 1 0.7803 0.8094 0.3108 11.00000 0.05 0.22 Q18 1 0.8951 0.8416 0.3787 11.00000 0.05 0.21 Q19 1 0.3173 0.7102 1.0220 11.00000 0.05 0.21 Q20 1 0.8439 0.5619 0.6432 11.00000 0.05 0.21 Q21 1 0.2404 0.8120 0.3065 11.00000 0.05 0.21 Q22 1 0.1259 1.0060 0.5751 11.00000 0.05 0.21 Q23 1 0.1605 0.9148 0.1761 11.00000 0.05 0.21 Q24 1 0.2632 0.5621 0.2150 11.00000 0.05 0.21 Q25 1 0.2513 0.9110 0.1394 11.00000 0.05 0.20 Q26 1 0.0770 0.3312 0.0535 11.00000 0.05 0.20 Q27 1 1.1354 0.3053 0.9101 11.00000 0.05 0.20 Q28 1 0.8635 0.4947 0.6693 11.00000 0.05 0.20 Q29 1 0.2597 0.4660 0.1915 11.00000 0.05 0.20 Q30 1 0.6450 0.7126 0.6199 11.00000 0.05 0.20 Q31 1 0.0457 0.6855 0.8590 11.00000 0.05 0.20 Q32 1 0.3793 0.4439 0.0420 11.00000 0.05 0.20 Q33 1 0.2732 0.7842 1.0813 11.00000 0.05 0.20 Q34 1 0.4128 0.2309 0.0568 11.00000 0.05 0.20 Q35 1 0.7438 0.8572 0.2958 11.00000 0.05 0.20 Q36 1 0.1286 0.6858 0.6503 11.00000 0.05 0.19 Q37 1 0.2371 0.6635 0.3910 11.00000 0.05 0.19 Q38 1 0.4450 0.5753 0.6869 11.00000 0.05 0.19 Q39 1 0.2502 0.8949 0.2538 11.00000 0.05 0.19 Q40 1 0.2581 0.9474 0.4632 11.00000 0.05 0.19 ; _shelx_res_checksum 88686 _olex2_submission_original_sample_id mcg1797 _olex2_submission_special_instructions 'No special instructions were received' # start Validation Reply Form _vrf_PLAT340_dalecorrectedmcg1797a_a ; PROBLEM: Low Bond Precision on C-C Bonds ............... 0.01019 Ang. RESPONSE: Low Bond Precision is Due to The Large Amount of Disorder ; # end Validation Reply Form