Compound;SMILES;MW;IC50 ± SEM for hAChE (nM);IC50 ± SEM for hBChE (nM)
5;COC1=C(C(OC)=O)C(CCCCCCCCNC2=C(C=CC=C3)C3=NC4=C2CCCC4)=CC=C1;474.65;20.8 ± 3.8;0.0352 ± 0.0077
6;O=C(OC)C1=C(OC)C=CC=C1CCCCCCCCNC2=C(C=CC(Cl)=C3)C3=NC4=C2CCCC4;509.09;2.54 ± 0.07;0.265 ± 0.027
7;O=C(OC)C1=C(OC)C=CC=C1CCCCCCCCNC2=C(C=C(OC)C=C3)C3=NC4=C2CCCC4;504.67;1260 ± 10;3.49 ± 0.09
8;COC1=CC=CC(CCCCCCCCNC2=C(C=CC=C3)C3=NC4=C2CCCC4)=C1;416.61;40.0 ± 3.3;7.72 ± 0.96
9;ClC1=CC2=NC(CCCC3)=C3C(NCCCCCCCCC4=CC(OC)=CC=C4)=C2C=C1;451.05;5.71 ± 0.43;25.8 ± 0.5
10;COC1=CC(OC)=CC(CCCCCCCCNC2=C(C=CC=C3)C3=NC4=C2CCCC4)=C1;446.64;47.2 ± 9.8;29.2 ± 5.4
11;ClC1=CC2=NC(CCCC3)=C3C(NCCCCCCCCC4=CC(OC)=CC(OC)=C4)=C2C=C1;481.08;5.10 ± 0.99;83.2 ± 3.5
12;OC1=C(C(OC)=O)C(CCCCCCCCNC2=C(C=CC=C3)C3=NC4=C2CCCC4)=CC=C1;460.62;17.0 ± 2.7;0.177 ± 0.005
13;OC1=C(C(OC)=O)C(CCCCCCCCNC2=C(C=CC(Cl)=C3)C3=NC4=C2CCCC4)=CC=C1;495.06;2.81 ± 0.14;4.25 ± 0.48
14;OC1=C(C(O)=O)C(CCCCCCCCNC2=C(C=CC=C3)C3=NC4=C2CCCC4)=CC=C1;446.59;184 ± 59;11.2 ± 2.3
15;OC1=C(C(O)=O)C(CCCCCCCCNC2=C(C=CC(Cl)=C3)C3=NC4=C2CCCC4)=CC=C1;481.03;13.4 ± 4.2;120 ± 12
16;OC1=CC=CC(CCCCCCCCNC2=C(C=CC=C3)C3=NC4=C2CCCC4)=C1;402.58;19.2 ± 4.0;3.74 ± 0.10
17;OC1=CC=CC(CCCCCCCCNC2=C(C=CC(Cl)=C3)C3=NC4=C2CCCC4)=C1;437.02;4.19 ± 0.81;19.4 ± 4.0