"Common Hub Genes - Significant ePheWAS Results of 1,250 Different Mouse Traits" GENE Phenotype Category Brain Negative log10 P-value SLC1A2 Diencephalon 5-hydroxyindoleacetic acid (5-HIAA) level in adult males and females [ng/mg protein] Nervous system Ventral_tegmental_area 4.42259 EEF1A1 "Pain sensitivity, vocalization threshold to mild foot shock for males [mA]" Nervous system Hippocampus 5.26259 ALDOA Diencephalon 5-hydroxytryptamine turnover rates (5-HIAA/5-HT) in adult males and females [units] Nervous system Ventral_tegmental_area 6.23796 CALM3 Dopamine receptor ratio in striatum based on relative expression using Affymetrix Exon array probe sets for Drd1 and Drd2 [ratio] Nervous system Striatum 5.358 CALM3 "Early B-cell factor 1 (Ebf1, D1 medium spiny neuron expression signature) mRNA expression in striatum (caudate-putamen), first principal component generated using 8 Affymetrix exon-level probe sets (exons 4 to 11) " Nervous system Striatum 5.35289 CALM3 "Dock1 (D2 medium spiny neuron expression signature) mRNA expression in striatum (caudate-putamen), first principal component generated using six Affymetrix exon-level Dock1 probe sets (exon 45 to 50) and Striatum_E" Nervous system Striatum 4.83638 EEF1A1 "Ethanol-induced conditioned taste aversion, saccharin intake during trials 2-4 after 2 g/kg ethanol injections expressed as a residual (regression of mean intake scores on trial 1 intakes) (Group 2 g/kg) in 60 to 130-day-" Nervous system Brain 4.86139 EEF1A1 "Brain activity and coherence of electrical field oscillations, coherence at 5 Hz between local field potentials (LFP) at two sites (0.3 mm apart) in L2/3 of the primary whisker motor cortex in awake 6 t" Nervous system Pituitary_Male 4.85839 EEF1A1 "Prepulse inhibition of the acoustic startle response to a 110 db SPL, 10 kHz tone, 56 db SPL white-noise prepulse stimulus [%]" Nervous system Cerebellum 4.60251 EEF1A1 "Floor preference baseline, time on grid textured floor for experimental group of males [sec/min]" Nervous system Prefrontal_cortex 4.47634 EEF1A2 Cocaine self-administration - Inactive lever presses (0.032 mg/kg/infusion) Nervous system Cerebellum 5.16621 EEF1A2 "Left hemisphere brain weight in 8-week-old F1 hybrids between male BXD strains and C57BL/6J-R6/2 Huntington model, R6/2 cases only [mg]" Nervous system Brain 4.52811 ALDOA "Conditioned place preference (CPP) baseline control for cocaine CPP test, percentage of time spent in conditioned side before conditioning for males [%]" Nervous system Hypothalamus_Male 4.4603 ALDOC Dopamine receptor ratio in striatum based on relative expression using Affymetrix Exon array probe sets for Drd1 and Drd2 [ratio] Nervous system Striatum 5.03265 ALDOC "Reversal learning using a touchscreen assay, number of errors during early reversal learning when performance was at or below 50% accuracy (see Figure 5C) in 3-month-old males [n]" Nervous system Hypothalamus_Male 4.67528 ENO2 "Septum volume corrected for shrinkage, age, sex, plane of section, brain weight, and epoch [mm3]" Nervous system Cerebellum 7.29227 ENO2 "Substance P (tachykinin 1, Tac1, substance P, D1 medium spiny neuron expression signature) mRNA expression in striatum (caudate-putamen), first principal component generated using ten Affymetrix exon-level Tac1 pro" Nervous system Striatum 5.40382 ENO2 Dopamine receptor ratio in striatum based on relative expression using Affymetrix Exon array probe sets for Drd1 and Drd2 [ratio] Nervous system Striatum 4.76473