Compound_ID,SMILES,ALK2 IC50 (nM),NanoBRET ALK2 IC50 (nM)
M4K2149,CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=CC(OC)=C(C(N)=O)C=C4,17,55
14a,CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=CC=C(OC)C(C(N)=O)=C4,>1000,694
14b,CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=CC(OC)=CC(C(N)=O)=C4,102,588
7a,CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=CC(OC)=C(C(N)=O)S4,751,3371
7b,CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=CSC(C(N)=O)=C4OC,712,2811
8a,CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=C(OC)C(C(N)=O)=CS4,>1000,>5000
18a,CC1=C(C=NC=C1C2=CC=C(C(OC)=C2)C(NC)=O)C3=CC=C(C=C3)N4CCNCC4,>1000,>5000
18b,CC1=C(C=NC=C1C2=CC=C(C(OC)=C2)C(N(C)C)=O)C3=CC=C(C=C3)N4CCNCC4,>1000,>5000
20a,CC1=C(C=NC=C1C2=CC=C(C3=C2)C(NC3)=O)C4=CC=C(C=C4)N5CCNCC5,652,2336
20b,CC1=C(C=NC=C1C2=CC=C(C=C2)C(N)=O)C3=CC=C(C=C3)N4CCNCC4,477,2771
20c,CC1=C(C=NC=C1C2=CC=C(C(COC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCNCC4,687,3845
20d,CC1=C(C=NC=C1C2=CC(F)=C(C=C2)C(N)=O)C3=CC=C(C=C3)N4CCNCC4,263,1013
8b,CC1=C(C=NC=C1C2=CC(F)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCNCC4,24,81
20e,CC1=C(C=NC=C1C2=CC(Cl)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCNCC4,9,93
8c,CC1=C(C=NC=C1C2=CC(OC)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCNCC4,5,178
26a,CC1=C(C=NC=C1C2=CC(F)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCN(C)CC4,3,93
26b,CC1=C(C=NC=C1C2=CC(F)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCN(C(C)C)CC4,5,52
26c,CC1=C(C=NC=C1C2=CC(F)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4C[C@H](C)N(C)[C@H](C)C4,10,100
26d,CC1=C(C=NC=C1C2=CC(OC)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCN(C)CC4,<3,19
26e,CC1=C(C=NC=C1C2=CC(OC)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4CCN(C(C)C)CC4,5,18
26f,CC1=C(C=NC=C1C2=CC(OC)=C(C(OC)=C2)C(N)=O)C3=CC=C(C=C3)N4C[C@H](C)N(C)[C@H](C)C4,3,21