Compound,SMILE,PHF1 Kd (µM),PHF1 IC50
,,,
GGVKme3KPHR,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC1=CNC=N1)NC([C@H]2N(C([C@H](CCCCN)NC([C@H](CCCC[N+](C)(C)C)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC2)=O)=O)=O,22.3 ± 1.9,
,,,
GGVKme3KPH,NC([C@H](CC1=CNC=N1)NC([C@H]2N(C([C@H](CCCCN)NC([C@H](CCCC[N+](C)(C)C)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC2)=O)=O,52.0 ± 6.1,
,,,
VGVKme3KPH,NC([C@H](CC1=CNC=N1)NC([C@H]2N(C([C@H](CCCCN)NC([C@H](CCCC[N+](C)(C)C)NC([C@H](C(C)C)NC(CNC([C@H](C(C)C)N)=O)=O)=O)=O)=O)CCC2)=O)=O,48.0 ± 0.2,
,,,
VGVKme3KPL,NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCC[N+](C)(C)C)NC([C@H](C(C)C)NC(CNC([C@H](C(C)C)N)=O)=O)=O)=O)=O)CCC1)=O)=O,16.3 ± 3.0,
,,,
GGVKme3KPLR,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCC[N+](C)(C)C)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC1)=O)=O)=O,18.7 ± 4.1,
,,,
UNC7643,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCCN(C(C)C)CC)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC1)=O)=O)=O,10.1 ± 1.2,
,,,
UNC6640,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCCN(CC)C(C)C2=CC=CO2)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC1)=O)=O)=O,17.9 ± 4.6,
,,,
UNC6641,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCCN(C(C)C)CCC2=CC=CC=C2)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC1)=O)=O)=O,0.96 ± 0.03,1.6 ± 0.5
,,,
UNC7259,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCCN(C(C)C)CCCC2=CC=CC=C2)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC1)=O)=O)=O,,8 ± 3
,,,
UNC7253,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCCN(C(C)C)CC2=CC=CC=C2)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC1)=O)=O)=O,,19 ± 4
,,,
UNC7258,NC([C@H](CCCNC(N)=[NH2+])NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CCCCN(C(C)C)CCC2CCCCC2)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)=O)CCC1)=O)=O)=O,,21 ± 1