Pathway gene mut mut_rep wt_rep mut_wt_connectivity wt cell_line mut_wt_rep_pval mut_wt_conn_null_pval wt_mut_rep_vs_wt_mut_conn_pval kruskal_diff mut_wt_rep_c_pval mut_wt_conn_null_c_pval wt_mut_rep_vs_wt_mut_conn_c_pval prediction HALLMARK_ESTROGEN_RESPONSE_LATE RNF43 RNF43_G659fs 0.181818 0.454545 -0.075758 RNF43_WT 293 0.029401 0.177778 0.006761 0.530303 0.029401 0.177778 0.006761 LOF