SI Table 3. Time Course U-13C Glucose Tracing of TSC2-deficient treated with αIL-6 antibody or antibody control.,,,,,,,,
Peak areas of isotopologues grown in serum free media with αIL-6 or control antibody  (10ug/ml) for 24h and incubated with U13C glucose for the indicated times.,,,,,,,,
,,,,,,,,
,0h IgG,0h αIL-6,15min IgG,15min  αIL-6,30min IgG,30min αIL-6,60min IgG,60min αIL-6
,,,,,,,,
UTP-nega_13C9,377390.5695,180475.7112,349226.7699,256433.8257,336235.2025,188789.5752,477724.9719,307401.1532
UTP-nega_13C8,128077.9895,85170.47901,252141.6322,95981.30392,194717.4635,121677.9699,208458.9092,94929.60189
UTP-nega_13C7,14861.09982,9865.593514,42977.4787,21572.32605,76558.11897,58345.76102,106786.296,93491.29517
UTP-nega_13C6,0,0,16504.83441,18051.59496,63266.35346,54921.67642,225331.6555,164399.8827
UTP-nega_13C5,48536.99938,27608.34518,631884.419,261353.2156,1535011.05,896453.9039,2597975.893,1694613.529
UTP-nega,7365589.871,4570361.904,7077399.515,4544100.048,6492406.405,4237186.334,8374872.755,5148319.077
,,,,,,,,
sn-glycerol-3-phosphate_nega,918164.8214,398926.5781,196536.04,263252.2893,152137.3712,130236.2881,199754.8457,140566.2551
sn-glycerol-3-phosphate_13C3_nega,0,0,1983028.432,2321276.215,1884401.932,1113954.523,1779940.662,1433529.671
sn-glycerol-3-phosphate_13C2_nega,8631.244163,8582.461536,35583.44857,22636.94306,14013.12105,11991.16497,14028.84703,0
,,,,,,,,
ribose-5-phosphate_nega,280319.1053,127007.4609,31663.99887,61883.26408,0,33484.1444,19389.05341,26100.87398
ribose-5-phosphate_13C5_nega,0,0,320232.8154,478969.6487,316809.1488,274991.0329,277033.6245,308114.0755
ribose-5-phosphate_13C4_nega,0,0,0,0,0,0,0,0
ribose-5-phosphate_13C3_nega,0,0,14076.77827,30173.34412,28884.23187,24805.98601,20494.72736,21569.25675
ribose-5-phosphate_13C2_nega,62322.33701,86298.62896,99852.34907,180703.3158,132703.6898,145274.0637,127274.0373,90607.86948
ribose-5-phosphate_13C1_nega,33438.52247,13819.32006,17814.30678,23650.20884,14985.92503,15082.47885,36678.83971,33423.10863
,,,,,,,,
pyruvate_nega,14823.69035,14551.84868,6326.176599,10594.87339,0,0,10741.62752,7691.04316
pyruvate_13C3_nega,131605.9532,73070.67951,6616.546289,11490.96075,12712.16555,10945.64508,5550.091855,20945.9506
pyruvate_13C2_nega,4904295.206,3585652.507,451184.8749,467645.4111,348733.2516,431739.3281,371154.6621,498264.5778
pyruvate_13C1_nega,0,22749.20441,24337.95324,20518.74665,51419.40335,15148.59526,15659.54321,22335.45398
,,,,,,,,
phosphoenolpyruvate_nega,448904.3011,267197.9669,19420.53796,15058.68146,27933.00321,27602.07587,23387.43759,55014.17734
phosphoenolpyruvate_13C3_nega,15324.07046,25579.25425,200836.2882,202316.0549,190319.5799,151336.78,211778.2248,107794.3079
phosphoenolpyruvate_13C2_nega,588388.9919,410632.4179,7326.944967,16508.05924,5817.774365,0,0,0
phosphoenolpyruvate_13C1_nega,11975.72458,0,0,0,0,4163.525823,0,0
,,,,,,,,
oxaloacetate_nega,118010.991,103863.1611,171499.7985,175538.3906,192247.7376,147006.3088,140346.8639,165027.7986
oxaloacetate_13C4_nega,0,0,0,0,0,0,0,0
oxaloacetate_13C3_nega,39869.64225,58248.96019,76408.46429,90464.86051,217886.7361,173942.347,460285.4777,384046.0352
oxaloacetate_13C2_nega,1105880.81,1150395.963,735157.1731,1251382.264,1090061.247,669870.0118,1011824.122,815953.0073
oxaloacetate_13C1_nega,4344105.374,2984816.268,8262168.194,9471296.006,9481046.143,6631749.938,10650985.11,8482088.821
,,,,,,,,
malate_nega,18133917.38,17727667.91,6785517.165,6398214.483,10859679.12,6412324.453,11390520.75,6769885.702
malate_13C4_nega,51078.05936,0,0,70716.96869,0,0,118405.9464,94165.6381
malate_13C3_nega,18543.02975,16164.34645,197840.1321,99881.49793,376981.0907,199437.0169,382602.1096,295686.9791
malate_13C2_nega,271225.2316,244547.9063,221842.324,176499.8967,462566.6443,429868.8231,864701.1973,603208.6584
malate_13C1_nega,878386.0618,744161.016,289937.3485,354912.9139,455460.6215,337612.2567,546923.9948,384330.4642
,,,,,,,,
lactate_nega,27624060.23,19394736.43,1389191.786,1457422.783,2158545.971,3097126.389,1564308.617,1372262.338
lactate_13C3_nega,0,0,1291409.399,880414.2195,3646691.125,958973.5174,1368489.658,1288764.142
lactate_13C2_nega,107921.0859,82852.73449,27994.78563,26962.96996,31946.35461,25554.17724,15276.59714,12777.54639
lactate_13C1_nega,865650.081,710979.3873,91468.1595,97376.08411,84241.19349,143563.8986,98994.75487,80851.15542
,,,,,,,,
isocitrate_nega,89449.13378,58389.72047,19974.00199,15459.15554,7385.816594,8966.898181,4891.505037,16282.63629
isocitrate_13C6_nega,0,0,0,0,0,0,0,0
isocitrate_13C5_nega,0,0,0,7536.740112,0,0,0,0
isocitrate_13C4_nega,0,0,0,0,0,0,0,0
isocitrate_13C3_nega,0,0,0,0,0,0,10604.04783,0
isocitrate_13C2_nega,0,0,6589.533553,7604.906504,5319.275435,0,10412.18834,0
isocitrate_13C1_nega,0,0,0,0,6001.076647,0,5342.566111,0
,,,,,,,,
IDP-nega_13C9,0,0,0,0,0,0,0,0
IDP-nega_13C8,0,0,0,0,0,0,0,0
IDP-nega_13C7,0,0,0,0,0,0,0,0
IDP-nega_13C6,0,0,0,0,0,0,0,0
IDP-nega_13C5,0,0,0,0,8623.65772,11863.97744,11864.12195,9705.537992
IDP-nega_13C10,0,0,0,0,9699.801798,0,0,0
IDP-nega,106834.7762,92850.40176,184222.9321,187556.003,223239.7715,120232.6509,186545.9261,179080.2379
,,,,,,,,
GTP-nega_13C9,0,0,0,0,0,0,0,0
GTP-nega_13C8,0,0,0,0,0,0,0,0
GTP-nega_13C7,0,0,0,0,0,0,0,0
GTP-nega_13C6,0,0,0,0,0,0,0,0
GTP-nega_13C5,0,0,0,0,0,0,0,0
GTP-nega_13C10,0,0,0,0,0,0,0,0
GTP-nega,275126.5883,148804.9784,434972.2966,313454.4667,379402.2198,272086.2585,508718.9386,402045.6918
,,,,,,,,
glycerate_nega,169470.1871,94745.15401,236041.4881,262098.8563,362396.3188,158457.1288,274718.3407,177559.6357
glycerate_13C3_nega,0,0,6491.558417,0,6472.771586,0,12996.13986,0
glycerate_13C2_nega,0,0,0,0,11867.23887,4321.507699,0,0
glycerate_13C1_nega,28049.53756,24811.18342,81982.74277,86304.61233,136989.7167,70121.38042,196354.1231,116504.2271
,,,,,,,,
glutathione_nega,14091588.77,11195116.2,19818629.48,29697667.61,21873055.47,16912632.36,25127961.64,17759674.54
glutathione_13C5_nega,0,0,0,0,0,4314.275612,0,0
glutathione_13C4_nega,0,0,0,0,7553.650588,5376.035374,0,5393.764505
glutathione_13C3_nega,37759.00969,26968.71344,23726.4131,37753.67259,42070.39348,26962.7516,41006.72894,43052.97873
glutathione_13C2_nega,203709.1065,144497.059,173851.6749,278130.0145,260639.2472,174805.91,308436.6635,191086.3868
glutathione_13C1_nega,1019697.662,1195853.745,1721047.529,1809715.947,1588650.509,932409.5417,1814706.372,1061264.922
,,,,,,,,
glucose-6-phosphate_13C6,0,0,0,22082.06142,14020.56364,0,0,19826.02055
glucose-6-phosphate_13C5,49869.78883,27925.90454,76011.86574,86834.21985,58918.01442,68632.31784,99838.96184,116273.1548
glucose-6-phosphate_13C4,0,0,0,0,0,0,0,0
glucose-6-phosphate_13C3,0,0,416005.0885,486304.3492,0,0,317127.3376,313649.0355
glucose-6-phosphate_13C2,0,0,0,28649.04343,0,0,13801.0497,27747.8519
glucose-6-phosphate_13C1,59987.46351,0,30728.81408,43516.74346,44087.70986,0,23462.44876,45410.53185
glucose-6-phosphate,208616.6273,201638.6108,72597.29791,147780.9837,19225.20536,68713.36325,78635.27574,136835.683
,,,,,,,,
glucose-1-phosphate_13C6,0,0,100688.1339,94182.01071,61027.2892,36023.79494,92086.36034,51815.8359
glucose-1-phosphate_13C5,89130.12719,64137.32703,101891.681,92233.72826,92620.54578,63621.32842,72381.70952,61565.69122
glucose-1-phosphate_13C4,112967.3287,138535.7481,67297.32048,113838.8422,103558.4588,126250.1041,133041.0843,142072.8095
glucose-1-phosphate_13C3,188459.5203,92044.6573,323576.5768,252202.1707,305591.2952,192860.879,266205.438,186534.4544
glucose-1-phosphate_13C2,1186010.674,882273.4855,1658231.391,1520424.468,1920638.499,996615.0932,1551329.973,1132668.614
glucose-1-phosphate_13C1,453842.1513,332806.1317,808054.6798,903112.5238,801732.7637,570944.9448,915849.6467,579423.6223
glucose-1-phosphate,393003.18,194010.131,288496.8234,263944.812,224944.9176,136398.7116,299439.6137,168400.8573
,,,,,,,,
fructose-6-phosphate_13C6,0,0,220113.5061,171924.4483,253600.3455,224016.7466,298681.1702,170430.748
fructose-6-phosphate_13C5,0,0,0,0,0,0,0,0
fructose-6-phosphate_13C4,0,0,0,0,0,0,0,0
fructose-6-phosphate_13C3,0,0,0,0,0,0,4554.42745,0
fructose-6-phosphate_13C2,0,8394.759136,0,0,4315.468061,5365.889997,0,4312.532995
fructose-6-phosphate_13C1,0,0,0,7550.10067,0,0,0,0
fructose-6-phosphate,272691.0085,154327.9686,29351.01978,18339.76326,14022.41172,14020.18316,4313.909055,8631.054774
,,,,,,,,
"fructose-1,6-bisphosphate_13C6",0,10568.30946,7011731.735,5958060.621,6320878.776,3829116.144,6190879.826,3619945.58
"fructose-1,6-bisphosphate_13C5",27001.9458,16177.86088,147442.0418,219040.1582,163298.1697,74219.71431,121404.1102,112184.0994
"fructose-1,6-bisphosphate_13C4",67723.68897,17236.2064,122524.5097,72333.51501,68851.12793,46959.10131,86551.20249,49844.5142
"fructose-1,6-bisphosphate_13C3",55217.31603,24503.48702,181138.0064,183214.1669,148416.8592,72017.33924,122048.4922,151723.2505
"fructose-1,6-bisphosphate_13C2",99642.63462,74838.26289,78013.62903,62515.32861,68368.1903,22918.92879,48827.08819,0
"fructose-1,6-bisphosphate_13C1",348851.8289,183637.1004,63466.58955,49459.36341,74188.91592,46858.49732,37190.95564,0
"fructose-1,6-bisphosphate",4988151.235,2880275.875,137143.8012,0,105991.9556,35838.10096,72383.94904,0
,,,,,,,,
dUTP-nega_13C9,0,0,0,0,0,0,0,0
dUTP-nega_13C8,0,0,0,0,0,0,0,0
dUTP-nega_13C7,0,0,0,0,0,0,0,0
dUTP-nega_13C6,0,0,0,0,0,0,0,0
dUTP-nega_13C5,0,0,0,0,0,0,0,0
dUTP-nega,12956.33088,0,0,0,8627.710727,0,0,0
,,,,,,,,
dTTP-nega_13C9,23726.51691,28044.54306,37804.76911,44220.3156,84143.83715,63654.56593,155960.8313,169312.7983
dTTP-nega_13C8,15148.33011,0,55042.56579,48537.15416,93424.20662,56094.44703,247035.9418,186167.2503
dTTP-nega_13C7,40983.4005,40994.06581,678809.6807,391782.5346,1605236.192,1039737.436,2658709.787,2043799.633
dTTP-nega_13C6,0,13932.45907,25901.91935,10783.4155,83132.14381,75703.76704,213659.5535,148781.2302
dTTP-nega_13C5,0,11864.09009,74440.28411,46402.62718,90517.73786,68952.43271,66880.05967,92549.23018
dTTP-nega_13C10,0,9708.46588,4306.625939,6420.93339,29145.3618,5394.710071,49624.38179,36679.4635
dTTP-nega,118579.7452,86530.17511,63998.58893,78784.15644,58523.96269,52822.29891,84065.22297,60410.80489
,,,,,,,,
dGTP_13C9,0,0,0,0,6472.394552,0,0,0
dGTP_13C8,0,0,4314.008266,0,0,0,0,0
dGTP_13C7,0,0,4313.915932,0,24599.36379,0,33439.19332,22653.66116
dGTP_13C6,0,0,12938.41056,0,53939.62153,22649.9053,176834.6332,90569.60508
dGTP_13C5,0,0,145642.3148,73345.30753,631689.3765,379951.4659,1438800.272,847218.6554
dGTP_13C10,0,0,0,0,0,0,4313.937003,5396.212936
dGTP,13985200.31,8285926.659,15755746.58,14932855.39,16836521.32,11623444.8,20252789.88,15192676.07
,,,,,,,,
D-glyceraldehdye-3-phosphate_nega,738047.0065,394037.3202,28045.26576,27619.90212,18862.11287,14018.9412,11445.25794,6418.929963
D-glyceraldehdye-3-phosphate_13C3_nega,0,0,1537802.767,1104730.273,952787.7735,797682.9879,880151.2724,1125648.337
D-glyceraldehdye-3-phosphate_13C2_nega,91076.49631,35425.47601,19051.57943,24934.26256,23379.02787,16627.21093,15752.49273,27656.6441
D-glyceraldehdye-3-phosphate_13C1_nega,48549.72837,24678.72943,6472.433446,5486.166657,0,0,0,0
,,,,,,,,
dGDP-nega_13C9,0,0,0,0,0,0,0,0
dGDP-nega_13C8,0,0,0,0,0,0,0,0
dGDP-nega_13C7,9708.561784,0,0,0,0,0,0,0
dGDP-nega_13C6,0,0,0,0,5394.798829,0,9687.304294,6472.445863
dGDP-nega_13C5,0,0,20495.57426,0,34520.20345,45325.87912,117597.9882,78665.47082
dGDP-nega_13C10,0,0,0,0,0,0,0,0
dGDP-nega,1595396.095,778426.7696,1342987.635,1581219.313,1582687.39,1247143.109,1536331.819,1440677.463
,,,,,,,,
dCTP-nega_13C9,8627.850119,0,0,5462.084811,0,0,0,17262.0719
dCTP-nega_13C8,0,0,5391.524137,0,5391.469028,0,0,0
dCTP-nega_13C7,0,0,0,0,0,0,0,0
dCTP-nega_13C6,0,0,0,0,0,0,0,0
dCTP-nega_13C5,0,0,0,0,0,0,0,0
dCTP-nega,42090.60486,36680.02575,55014.14759,64747.91149,77672.02082,28053.1737,80913.19183,52325.36731
,,,,,,,,
dATP-nega_13C9,0,0,0,0,0,0,0,0
dATP-nega_13C8,0,0,0,0,0,0,0,0
dATP-nega_13C7,0,0,0,0,0,0,0,0
dATP-nega_13C6,0,0,0,6469.19615,0,0,0,0
dATP-nega_13C5,7550.187888,0,0,11867.3493,0,0,7550.133617,0
dATP-nega_13C10,0,0,0,0,5394.827407,0,0,8629.337467
dATP-nega,30292.51481,10754.03864,25890.15685,24812.23859,53591.7368,44160.21588,167210.3119,95916.91601
CTP-nega_13C9,0,0,0,0,0,0,0,0
CTP-nega_13C8,0,0,0,0,0,0,0,0
CTP-nega_13C7,0,0,0,0,5391.574961,0,7556.853732,0
CTP-nega_13C6,0,0,0,0,0,0,0,0
CTP-nega_13C5,6484.619887,0,18617.69349,38850.12172,30206.86178,30179.43102,53356.1077,51779.74052
CTP-nega,589909.9969,393817.5393,709332.2908,586954.0878,743386.2332,479482.8621,1043558.075,827109.3452
,,,,,,,,
citrate_nega,7991620.599,3682621.975,4603050.543,5475936.996,3474823.615,2945344.755,2969770.35,6597673.513
citrate_13C6_nega,0,0,0,0,5394.747915,5392.508638,7463.272745,7503.604888
citrate_13C5_nega,23512.48982,10786.78522,44027.95883,63418.42092,74103.43457,66069.76226,83124.83973,62831.31551
citrate_13C4_nega,0,0,4313.134897,12966.28985,31092.16141,30346.1642,37442.92786,51589.49729
citrate_13C3_nega,0,0,10781.67828,21410.77392,15240.45699,9830.08132,5428.754397,8597.303346
citrate_13C2_nega,67603.9723,102601.9861,113726.3789,108448.7651,72753.4088,105917.9461,56934.66791,175935.0486
citrate_13C1_nega,853916.9314,481906.1057,309531.9812,424409.5655,313317.008,246823.9937,302654.55,508297.3002
,,,,,,,,
ATP-nega_13C9,0,0,77668.21175,46380.93663,361305.8752,197257.5713,993195.4403,617473.2839
ATP-nega_13C8,0,0,23731.86557,8631.082847,29122.47338,18339.39741,62567.65247,53940.98549
ATP-nega_13C7,18322.66758,14022.61166,43126.95756,27994.00385,44225.82751,39915.25744,72274.68203,74433.41733
ATP-nega_13C6,317152.3452,184186.5313,314430.9301,329386.3837,336808.5103,317983.2636,525112.7728,326559.5491
ATP-nega_13C5,1842768.471,1667881.647,2012297.504,1453994.286,2060187.985,1506567.699,2365664.157,1861256.824
ATP-nega_13C10,0,0,5394.933331,0,84130.88449,24788.11271,207074.4443,97086.70951
ATP-nega,13476158.95,8158192.096,10241562.2,10918367.12,16538340.18,12813498.1,20686131.1,14347803.42
,,,,,,,,
aspartate_nega,7110155.235,5152545.903,15533371.37,16078380.45,14423034.3,10739360.97,17143534.93,12604987.81
aspartate_13C4_nega,8044.282995,0,6432.118937,0,17224.16141,0,21575.88726,14031.12088
aspartate_13C3_nega,0,0,129445.7863,91695.77139,310824.0306,220049.6603,441762.3628,308092.297
aspartate_13C2_nega,120460.4678,122782.2322,198846.5889,235228.2329,306490.2104,391735.1311,877773.7912,827093.6216
aspartate_13C1_nega,0,0,0,0,0,0,0,0
,,,,,,,,
5-phosphoribosyl-1-pyrophosphate,22863.12979,5394.821046,117581.5621,185670.4296,50699.41055,188777.8904,63659.24354,200653.7311
5-phosphoribosyl-1-pyrophosphate_13C1,5396.119862,0,0,0,0,0,0,0
5-phosphoribosyl-1-pyrophosphate_13C2,808326.9421,292272.6544,2024106.082,3441794.89,1140030.756,1882256.439,2913435.613,3180473.078
5-phosphoribosyl-1-pyrophosphate_13C3,17319.82629,10798.24809,23890.80537,37698.67502,11830.35502,57262.49304,15096.41253,53580.21062
5-phosphoribosyl-1-pyrophosphate_13C4,49391.54598,0,74411.68059,116503.4132,67937.72983,84153.13716,112279.2512,88351.37116
5-phosphoribosyl-1-pyrophosphate_13C5,8765.181283,0,64310.50712,56155.65631,40079.61614,28578.50763,0,50077.33309
,,,,,,,,
ADP-nega,1223372.933,861702.2374,1420543.953,1653307.162,1595299.27,1370753.403,1774774.469,1350930.104
ADP-nega_13C1,157600.5624,128048.6652,168957.7741,214511.4343,189801.8679,153173.4892,254722.7673,209812.3796
ADP-nega_13C2,16201.93281,22265.71303,25915.12556,26967.58016,31023.25118,21580.97571,30202.63367,32359.1071
ADP-nega_13C3,0,7550.075534,6472.63221,5391.60768,9730.738679,6578.36445,7541.560754,6397.917653
ADP-nega_13C4,0,5394.784232,0,0,5391.306329,0,0,6466.365777
ADP-nega_13C5,0,0,8628.023609,15103.5085,50557.287,36675.65004,126366.086,100323.2463
ADP-nega_13C6,0,0,0,0,6472.303462,0,18326.21691,24817.57819
ADP-nega_13C7,0,4312.356485,0,0,0,0,11864.0705,0
ADP-nega_13C8,0,0,0,0,0,0,0,0
ADP-nega_13C9,0,0,0,0,0,0,0,0
ADP-nega_13C10,6472.578264,0,0,0,0,0,0,0
,,,,,,,,
3-phosphoglycerate,538094.4319,362547.8472,25348.2645,20214.84081,32062.31267,21570.23969,25495.02436,19393.33828
3-phosphoglycerate_13C1,54354.67603,19331.35849,0,0,0,0,0,0
3-phosphoglycerate_13C2,31687.67483,20131.46711,38216.08801,58022.66696,79904.02675,26721.58273,99315.5647,106698.9177
3-phosphoglycerate_13C3,0,0,687539.4821,642844.3666,642280.7428,357104.8785,565164.2954,500343.3462
"1,3-diphosphateglycerate",442373.1334,351352.8794,692121.3692,868032.2015,879360.9477,819262.7884,1048794.991,1385005.063
"1,3-diphosphateglycerate_13C1",381472.6152,227520.0544,293240.8818,227891.0562,191224.6179,172455.1126,265154.2315,242179.9035
"1,3-diphosphateglycerate_13C2",88666.41882,36469.31956,39731.38708,66239.27867,45311.41973,49567.71989,39433.23811,40013.25678
"1,3-diphosphateglycerate_13C3",73300.79391,66387.36051,72816.18978,90053.55427,26318.40981,22076.64538,34821.71042,0
,,,,,,,,
a-ketoglutarate_13C1(2)_nega,14180.116,12048.81108,22670.15082,25815.34661,53152.58766,13991.91023,36917.69822,18518.10629
a-ketoglutarate_13C1_nega,0,0,0,0,0,0,0,0
a-ketoglutarate_13C2(2)_nega,0,0,6180.257811,0,0,7560.705984,5452.338787,9207.482391
a-ketoglutarate_13C2_nega,0,28967.05141,0,0,0,0,41814.01227,0
a-ketoglutarate_13C3(2)_nega,0,0,0,0,12295.62835,0,0,0
a-ketoglutarate_13C3_nega,0,17346.95525,0,0,0,0,0,0
a-ketoglutarate_13C4(2)_nega,0,0,11642.93718,36402.78833,16862.99101,21449.4769,8897.441262,30857.67836
a-ketoglutarate_13C4_nega,0,0,16090.71423,28605.92266,0,11347.33096,7106.504663,18983.03897
a-ketoglutarate_13C5_nega,0,0,0,0,0,0,0,0
a-ketoglutarate_nega,26960.2944,11858.99093,16256.62315,30174.53379,30194.7959,29142.23001,22506.54353,15025.00063
,,,,,,,,
a-ketoglutarate_13C1_nega,14180.116,12048.81108,22670.15082,25815.34661,53152.58766,13991.91023,36917.69822,18518.10629
a-ketoglutarate_13C2_nega,0,28967.05141,6180.257811,0,0,7560.705984,47266.35106,9207.482391
a-ketoglutarate_13C3_nega,0,17346.95525,0,0,12295.62835,0,0,0
a-ketoglutarate_13C4_nega,0,0,27733.65141,65008.71099,16862.99101,32796.80786,16003.94593,49840.71733
a-ketoglutarate_13C5_nega,0,0,0,0,0,0,0,0
a-ketoglutarate_nega,26960.2944,11858.99093,16256.62315,30174.53379,30194.7959,29142.23001,22506.54353,15025.00063
,,,,,,,,
fumarate_13C1(2)_nega,55906.20005,47705.16135,24769.84525,38699.38934,51799.06818,16175.99743,52814.41434,21709.45402
fumarate_13C1_nega,178731.1714,110047.9694,0,350637.2092,277228.0933,252995.3691,237251.9521,189547.7737
fumarate_13C2(2)_nega,0,0,10704.06041,16184.5687,38029.98804,52905.1837,117042.2981,72521.77155
fumarate_13C2_nega,4425841.826,3125604.079,1390486.913,1483756.952,1858500.929,1231711.916,2230364.529,1407793.677
fumarate_13C3(2)_nega,57927.87835,37734.65013,45448.90197,44220.22409,80739.17493,42534.93161,93033.63514,36396.82392
fumarate_13C3_nega,222319.2294,178402.1426,173751.5841,143344.0467,245257.5891,135173.6816,169279.8308,203042.3643
fumarate_13C4_nega,0,0,10415.6839,16758.06077,34175.89753,21966.84994,85691.55557,44718.62571
fumarate_nega,4710797.224,2756562.369,2265214.831,2072173.89,2873109.968,2011803.588,2810348.36,1769979.613
,,,,,,,,
fumarate_13C1_nega total,234637.3715,157753.1308,24769.84525,389336.5985,329027.1615,269171.3665,290066.3664,211257.2277
fumarate_13C2_nega total,4425841.826,3125604.079,1401190.973,1499941.521,1896530.917,1284617.1,2347406.827,1480315.449
fumarate_13C3_nega total,280247.1078,216136.7927,219200.4861,187564.2708,325996.764,177708.6132,262313.4659,239439.1882
fumarate_13C4_nega total,0,0,10415.6839,16758.06077,34175.89753,21966.84994,85691.55557,44718.62571
fumarate_nega total,4710797.224,2756562.369,2265214.831,2072173.89,2873109.968,2011803.588,2810348.36,1769979.613
,,,,,,,,
succinate_13C1(2)_nega,41071.12552,28042.88825,43145.39222,32655.17072,58594.37515,37864.55901,91853.51462,43334.67092
succinate_13C1_nega,161099.9391,93693.55885,191609.4828,97081.56576,250917.4001,131221.017,209768.7384,171123.7588
succinate_13C2(2)_nega,0,0,11349.70964,13637.06201,27057.91143,21731.66182,80693.48038,33113.73091
succinate_13C2_nega,0,0,31948.39316,84189.98707,56517.68288,103377.0798,78715.58001,77136.87425
succinate_13C3(2)_nega,0,0,0,0,0,0,17259.88111,0
succinate_13C3_nega,0,0,0,0,7434.256391,0,0,0
succinate_13C4_nega,0,0,5391.342552,0,5378.795736,0,11871.22703,0
succinate_nega,3406202.014,1798457.836,1254746.834,978348.3956,1429647.172,891248.7907,1522419.899,906177.5556
,,,,,,,,
succinate_13C1_nega total,202171.0646,121736.4471,234754.875,129736.7365,309511.7753,169085.576,301622.253,214458.4297
succinate_13C2_nega total,0,0,43298.1028,97827.04908,83575.59431,125108.7416,159409.0604,110250.6052
succinate_13C3_nega total,0,0,0,0,7434.256391,0,17259.88111,0
succinate_13C4_nega total,0,0,5391.342552,0,5378.795736,0,11871.22703,0
succinate_nega total,3406202.014,1798457.836,1254746.834,978348.3956,1429647.172,891248.7907,1522419.899,906177.5556
,,,,,,,,
dihydroxyacetone phosphate,1654331.333,880206.5409,31125.8061,55258.65211,23489.13697,18448.53482,22500.11035,19901.54877
dihydroxyacetone phosphate_13C1,35148.41631,24892.04004,291428.6844,256958.3124,267427.0324,164304.9761,257982.9473,175388.9644
dihydroxyacetone phosphate_13C2,4490726.447,2354154.081,1012366.952,1455336.118,767443.9541,635419.9524,686932.7177,478764.6546
dihydroxyacetone phosphate_13C3,168243.6674,105696.9439,2357994.238,1888982.026,1268090.34,1072222.75,1425493.533,1346427.855
,,,,,,,,
erythrose-4-phosphate,66748.94124,66053.63164,24863.43683,36540.64927,10213.91307,28060.97236,32782.30814,22572.06327
erythrose-4-phosphate_13C1,0,0,0,19410.40483,0,0,0,0
erythrose-4-phosphate_13C2,26308.83114,0,74486.42099,0,5875.735242,0,0,0
erythrose-4-phosphate_13C3,0,0,0,9498.481767,0,10513.39548,0,0
erythrose-4-phosphate_13C4,0,0,89090.20502,106816.4761,102415.2353,62513.76917,59913.04531,56853.11382
,,,,,,,,
6-phospho-D-gluconate,14013.70984,16219.15896,16479.35788,20856.98071,16180.53615,30172.82455,36762.96453,21575.95993
6-phospho-D-gluconate_13C1,0,0,5387.45534,0,0,0,4314.863137,4313.87271
6-phospho-D-gluconate_13C2,0,0,0,0,0,0,0,0
6-phospho-D-gluconate_13C3,0,0,1621342.744,2382346.501,1242734.369,1025933.176,1978538.685,1865178.34
6-phospho-D-gluconate_13C4,0,0,177029.7614,308580.0749,0,103558.025,175624.9235,249134.2618
6-phospho-D-gluconate_13C5,0,0,23951.99286,29328.25729,12401.08728,12495.76621,19081.04398,23721.06198
6-phospho-D-gluconate_13C6,5321.933514,0,56860.71199,0,49147.41215,21548.86177,26021.33798,39014.5227
,,,,,,,,
6-phosphogluconolactone,5335.387356,17961.0096,6642.624112,16026.38633,0,7319.273749,16078.5845,0
6-phosphogluconolactone_13C1,67901.1539,42738.25848,17527.10707,20758.19204,25349.09662,0,17048.55259,17310.35424
6-phosphogluconolactone_13C2,3375803.989,2257023.568,424282.4268,460246.096,319318.0977,162494.115,206624.0057,180074.1774
6-phosphogluconolactone_13C3,336570.3216,105518.7969,28873.76301,71128.31975,62562.14165,33794.72635,55589.5206,35567.11865
6-phosphogluconolactone_13C4,138393.4915,0,131374.5997,114898.3524,0,0,130493.9721,0
6-phosphogluconolactone_13C5,0,8624.402748,0,54011.24004,21572.77027,0,46025.92466,25849.70557
6-phosphogluconolactone_13C6,24401.76607,0,8427.601569,10533.27566,17025.83856,15017.94071,36728.93357,0
,,,,,,,,
UMP_13C9,0,0,0,0,0,0,0,0
UMP_13C8,0,0,0,0,0,0,0,0
UMP_13C7,0,0,0,0,0,0,0,0
UMP_13C6,0,0,0,0,0,0,9691.254331,0
UMP_13C5,0,0,6461.110405,0,0,0,0,21575.82565
UMP,125614.0981,56967.31545,81950.57072,48583.57618,88453.42083,59370.94072,60005.83316,43145.2215
,,,,,,,,
serine_posi,4056111.593,2249056.53,8429969.473,6753078.094,8214630.844,4621114.264,6815840.518,5166869.699
serine_13C3_posi,0,0,407734.6476,286943.392,752898.1673,277235.3839,790524.8956,319320.6066
serine_13C2_posi,9695.403603,8630.697861,31281.66048,28048.19298,45306.53864,20498.33819,15111.28828,21576.07572
serine_13C1_posi,250264.5761,120818.0845,326810.9305,295586.5703,538471.1693,234081.4177,499463.3635,332450.825
,,,,,,,,
N-carbamoyl-L-aspartate_13C5,0,0,0,0,7550.067165,0,5394.713984,0
N-carbamoyl-L-aspartate_13C4,52840.93148,46448.43646,115183.3769,86296.58998,124037.7348,83064.9007,133805.3325,127290.4441
N-carbamoyl-L-aspartate_13C3,0,0,0,0,0,0,0,0
N-carbamoyl-L-aspartate_13C2,0,0,0,0,0,0,0,0
N-carbamoyl-L-aspartate_13C1,0,0,0,0,0,0,0,0
N-carbamoyl-L-aspartate,0,0,0,0,4313.913699,0,0,0
,,,,,,,,
leucine_isoleucine_posi,41941028.46,32779987.4,60265283.14,62037545.17,57037008.85,44806184.12,47391460.56,62408262.36
leucine_isoleucine_13C6_posi,0,0,0,0,0,20452.20655,14009.49312,19310.77447
leucine_isoleucine_13C3_posi,103786.2129,71204.4732,133225.3275,155307.6375,207472.419,136966.9455,185485.8042,191118.0281
leucine_isoleucine_13C2_posi,2280569.478,1418002.664,3952081.671,3505504.572,3589698.411,2247892.614,3592587.906,2725314.865
leucine_isoleucine_13C1_posi,3711790.956,1759203.746,5137654.603,5320021.207,4425188.409,3279152.413,4440331.241,4870599.551
,,,,,,,,
IMP_13C9,0,0,4319.042289,0,0,0,0,0
IMP_13C8,0,0,0,0,0,0,0,0
IMP_13C7,0,0,0,0,0,0,0,0
IMP_13C6,0,0,23731.92878,11863.94287,11890.2389,7550.200991,4259.793595,19417.13813
IMP_13C5,0,0,42033.45515,4153.151814,50694.91448,34508.39588,35601.08626,39052.8935
IMP_13C10,0,0,0,0,0,0,0,0
IMP,98623.29633,0,58249.01143,107753.7682,114344.5862,72869.95899,85940.75351,89533.60266
,,,,,,,,
guanosine_13C9,0,0,6472.474989,14960.20202,0,0,0,0
guanosine_13C8,6591.583019,0,0,0,0,0,9710.863656,0
guanosine_13C7,15463.25836,9708.733952,22653.79615,17255.15566,10786.3207,15039.50929,22471.14846,20498.29038
guanosine_13C6,0,0,0,0,0,0,0,0
guanosine_13C5,0,0,0,0,0,0,0,0
guanosine_13C10,6568.446695,0,24812.3857,42070.28822,8630.961391,11871.64542,9708.540258,15100.34335
guanosine,0,0,17337.00504,17255.11525,8627.631182,11816.89758,0,0
,,,,,,,,
GMP_13C9,0,0,0,0,0,0,0,0
GMP_13C8,0,0,0,0,0,0,0,0
GMP_13C7,0,0,0,0,0,0,0,0
GMP_13C6,0,0,0,0,6466.760035,0,0,0
GMP_13C5,0,0,0,0,0,0,0,0
GMP_13C10,0,0,0,0,0,0,0,0
GMP,58208.99302,44252.52549,35647.51028,25744.61387,38254.68278,21621.92684,69881.76302,62158.98693
,,,,,,,,
glycine_posi,0,0,0,0,0,0,0,0
glycine_13C2_posi,0,0,0,0,0,0,0,0
glycine_13C1_posi,0,0,0,0,0,0,0,0
,,,,,,,,
glutathione_pos,22854011.29,16177227.99,36007658.28,36565025.19,34003010.86,27515195.62,44842861.08,28203864.22
glutathione_13C5_pos,0,8627.774021,9712.054079,7550.110889,39914.75167,6461.344437,19276.51596,9647.787452
glutathione_13C4_pos,16194.998,9705.682802,23715.14031,10790.55955,17257.81946,20462.92795,51803.09186,19430.73785
glutathione_13C3_pos,110037.1963,51783.00362,122916.6105,132681.3791,142395.8548,107861.868,181213.968,122363.3419
glutathione_13C2_pos,1439053.218,855422.9088,1648687.005,1774065.69,2091015.76,1655670.612,2347602.244,1759563.497
glutathione_13C1_pos,1781331.384,1014533.74,2214637.216,2442257.078,2110926.511,1807695.247,3188895.979,2405447.989
,,,,,,,,
glutathione disulfide_pos,823039.6151,633724.0211,1981379.232,2374761.444,3786363.556,2681591.575,2811396.886,3547296.942
glutathione disulfide_13C5_pos,0,0,0,6472.366085,0,0,0,0
glutathione disulfide_13C4_pos,0,0,0,0,12944.89558,8627.869435,0,4317.135982
glutathione disulfide_13C3_pos,10786.59409,6472.351491,20545.78667,24811.67917,38834.41794,26967.62539,14023.46928,22624.16854
glutathione disulfide_13C2_pos,10815.03974,0,35582.31905,45273.23436,114344.8204,57044.06871,78748.73309,65805.78936
glutathione disulfide_13C1_pos,103670.8157,96007.49246,230860.8718,243788.4012,387260.8166,321804.6273,298687.5038,343623.8905
,,,,,,,,
glutamine_pos,31456359.57,14342955.87,43190250.41,37984367.06,47699790.45,30773163.47,51428085.27,38049769.06
glutamine_13C5_pos,0,0,14057.27481,7182.422331,10590.58665,12999.12062,15758.65817,26811.49979
glutamine_13C4_pos,0,0,0,0,0,0,0,0
glutamine_13C3_pos,0,6357.393523,13808.69194,11723.0258,19163.26822,0,16226.27735,0
glutamine_13C2_pos,160619.7109,73686.4653,201792.0151,198526.0914,337924.5711,153420.9692,311695.1472,375298.9443
glutamine_13C1_pos,2704564.84,1830552.455,3880678.757,3504653.362,3967961.132,3768554.807,4263513.387,2829286.461
,,,,,,,,
deoxyguanosine_13C9,5355.286709,0,0,0,0,0,0,0
deoxyguanosine_13C8,0,0,4298.202732,0,0,0,0,0
deoxyguanosine_13C7,0,0,0,0,0,0,0,0
deoxyguanosine_13C6,0,0,0,0,0,0,0,0
deoxyguanosine_13C5,16181.28371,0,5394.833904,0,5391.688386,7550.152408,0,0
deoxyguanosine_13C10,0,0,0,0,0,0,0,0
deoxyguanosine,5395.615931,0,0,0,0,0,0,0
,,,,,,,,
cysteine_pos,0,4317.241813,0,12856.53777,11801.45901,6525.697426,4314.154876,6338.641048
cysteine_13C3_pos,0,0,0,0,0,0,0,0
cysteine_13C2_pos,0,0,0,0,0,0,0,0
cysteine_13C1_pos,0,0,0,0,0,0,0,5394.84845
,,,,,,,,
CMP_13C9,0,0,0,0,0,0,0,0
CMP_13C8,0,0,0,0,0,0,0,0
CMP_13C7,0,0,0,0,0,0,0,0
CMP_13C6,0,0,0,0,0,0,0,0
CMP_13C5,0,0,0,0,0,0,7550.015893,6631.797294
CMP,264388.582,172345.1042,254388.7825,278148.1642,288569.1175,216815.3566,376427.8197,261104.5127
,,,,,,,,
aspartate_13C4,0,0,4277.666491,0,8627.74215,6472.509907,10786.12338,0
aspartate_13C3,0,0,43148.96963,46391.36422,127211.4482,50640.7725,160793.3801,147779.8347
aspartate_13C2,7557.698534,9188.398204,31160.08073,39964.03208,79065.77688,87449.49525,195145.1215,183167.7625
aspartate_13C1,113203.883,65544.00396,155064.4759,160633.5795,100849.0872,135851.6184,174902.9068,144620.5636
aspartate,2553997.485,1365891.086,7821646.267,5391163.841,4622058.695,3845773.088,5524584.501,4371274.199
,,,,,,,,
AMP_13C9,0,0,0,0,0,0,0,0
AMP_13C8,0,0,0,0,0,0,0,0
AMP_13C7,0,0,25864.37075,4279.70239,5240.774235,5394.8484,8630.875985,10786.35981
AMP_13C6,0,0,49584.29363,28072.30972,50675.73172,17353.57506,61360.88702,40236.0349
AMP_13C5,0,0,32556.44367,15096.0902,40846.91616,24813.67214,83048.46056,75388.57012
AMP_13C10,0,0,0,0,0,0,0,0
AMP,786615.7684,458523.8208,828253.8532,1156122.865,867810.8445,937448.7455,1137440.198,1023516.516
,,,,,,,,
adenosine_13C9,0,0,0,0,0,0,5489.211562,0
adenosine_13C8,0,0,4418.897212,0,0,0,0,0
adenosine_13C7,4313.831666,0,0,0,0,0,0,0
adenosine_13C6,0,6476.007923,0,0,0,0,0,0
adenosine_13C5,0,4314.514015,0,0,0,0,0,0
adenosine_13C10,0,6472.529736,4396.031231,0,0,0,0,0
adenosine,37201.23573,0,0,0,0,21868.40206,13634.5515,0
,,,,,,,,
acetyl-CoA_pos,4314.004814,0,0,0,0,0,0,0
acetyl-CoA_13C2_pos,0,0,4256.355233,0,0,0,0,0
acetyl-CoA_13C1_pos,0,0,0,0,0,0,0,0
,,,,,,,,
3-phospho-serine_13C3,7550.180271,0,0,0,0,0,0,0
3-phospho-serine_13C2,111112.7557,57214.70293,20498.37087,44255.14839,9724.712422,0,21577.29176,16181.02416
3-phospho-serine_13C1,146596.1083,38913.02047,79304.92471,81137.03707,85896.82786,75474.27393,132380.7495,65830.339
3-phospho-serine,3640733.037,1537800.03,2279776.957,1317847.631,1916569.678,1206119.23,2277187.501,1062848.895
,,,,,,,,
alanine,9683091.354,5982939.184,3524486.36,3336765.249,1198647.68,665293.4786,1237809.062,762090.3861
alanine_13C1,427525.6629,229738.4024,142235.1949,170699.3042,66890.58378,24819.83272,28063.67773,67008.8877
alanine_13C2,5398.722204,8562.766699,0,5415.109207,5387.404725,4317.134079,11867.29129,7570.300808
alanine_13C3,0,0,1293368.204,890889.7412,1419383.429,645068.8259,1833134.012,870539.2494
,,,,,,,,
aminoimidazole carboxamide ribonucleotide,0,10783.47004,0,0,0,0,4319.394672,4204.975852
aminoimidazole carboxamide ribonucleotide_13C1,0,0,0,0,0,0,0,0
aminoimidazole carboxamide ribonucleotide_13C2,0,0,11867.3356,8636.484915,0,0,0,0
aminoimidazole carboxamide ribonucleotide_13C3,11817.14773,0,0,9453.902456,4313.821249,0,0,6469.130085
aminoimidazole carboxamide ribonucleotide_13C4,32359.8426,11890.42284,45187.607,61373.15508,39915.2917,32365.74161,50697.76702,44229.74271
aminoimidazole carboxamide ribonucleotide_13C5,8616.941063,0,0,7701.59177,12872.61784,7550.924611,0,6485.25595
aminoimidazole carboxamide ribonucleotide_13C6,0,0,11867.18749,20500.71131,6472.427333,11867.22798,17250.82926,9695.030033
aminoimidazole carboxamide ribonucleotide_13C7,7550.214535,9711.722814,22657.0679,26966.90871,17238.65692,18313.85327,20481.85712,0
aminoimidazole carboxamide ribonucleotide_13C8,0,6469.113162,0,0,5394.819306,0,0,0
aminoimidazole carboxamide ribonucleotide_13C9,0,0,9708.848173,0,0,0,7549.939875,0
,,,,,,,,
asparagine,1267458.24,787494.0598,845742.6242,809218.4057,840437.6904,537214.5122,994668.8096,611725.3879
asparagine_13C1,66138.13933,54844.09495,29412.0761,21548.50582,55766.07604,35987.58283,44673.72239,32457.55993
asparagine_13C2,15193.4908,14014.33589,19417.52229,10760.48401,17258.92103,20486.37018,65799.51887,34517.8459
asparagine_13C3,3210.326327,0,0,8543.101342,13950.72401,0,0,31031.0355
asparagine_13C4,0,0,0,0,0,6619.503245,0,13139.50508
,,,,,,,,
cytidine_13C5,0,0,0,0,0,0,0,0
cytidine,122976.5907,114344.231,79822.12365,99240.59251,133764.9023,81987.25879,118657.4619,114346.1031
cytidine_13C1,19417.81054,12944.75571,16181.21177,7540.486879,9711.762981,15103.47175,8631.6254,31284.66447
cytidine_13C2,6472.593324,0,0,0,0,0,0,0
cytidine_13C3,0,0,0,0,0,0,0,0
cytidine_13C4,0,0,0,0,0,0,0,0
,,,,,,,,
glutamate,28673434.04,21077683.42,39778316.81,39514461.3,43012034.54,36058902.15,55989265.12,36522228.35
glutamate_13C1,2724590.528,1595427.61,2651509.704,2508376.405,3857039.699,3489348.964,4823020.091,3056416.848
glutamate_13C1(2),702973.5394,427852.7947,649582.1888,510223.5767,867085.0038,691130.4194,1049397.537,814096.9152
glutamate_13C2,170937.9544,119745.9559,1451492.056,1388311.623,4243647.936,3597264.13,8633256.849,6570436.106
glutamate_13C2(2),129289.3599,60384.87113,128907.081,155497.3923,204366.2479,139488.8027,290775.3402,220957.1035
glutamate_13C3,6472.635091,7553.188115,58727.85962,39039.83968,195648.745,203851.489,529888.7229,366779.1519
glutamate_13C3(2),0,4317.109031,33081.3213,25460.04041,124777.5507,86491.27406,175587.8026,172344.0397
glutamate_13C4,0,0,17262.52373,29130.51465,180090.9599,124061.8007,281477.1503,261040.0017
glutamate_13C4(2),0,0,10796.76461,11829.48572,69028.22262,48558.17897,256735.2423,228874.0906
glutamate_13C5,0,0,9709.012462,10786.00066,90617.59822,42071.21209,175834.1967,88456.25865
,,,,,,,,
methionine,4836775.06,1962630.018,6363733.711,8034809.495,6753335.534,4352951.362,6320213.344,6058523.823
methionine_13C1,349056.9392,152392.3521,424498.3386,499267.633,438341.2419,282820.003,452513.5298,280485.8465
methionine_13C2,341465.4549,190065.8637,391286.8221,441472.8568,463753.0104,296809.0091,288671.8202,360181.7015
methionine_13C3,4695.998844,22935.7186,31217.6316,27168.27452,14450.67148,25368.13065,24789.98233,25800.84178
methionine_13C4,22915.42889,29172.04032,20080.28507,17896.68862,13537.38704,11449.15065,0,10685.18664
methionine_13C5,9654.953922,13032.48096,0,0,0,0,0,13061.58804
,,,,,,,,
Succinyl-coA,0,0,0,0,0,0,0,0
Succinyl-coA_13C1,0,0,0,0,0,0,0,0
Succinyl-coA_13C2,0,0,0,0,0,0,0,0
Succinyl-coA_13C3,0,0,0,0,0,0,0,0
Succinyl-coA_13C4,0,0,0,0,0,0,0,0