ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS 200 -0.615941795 -2.4177274 0.001264223 0.010442774 0.006595436 4509 "tags=79%, list=30%, signal=56%" PDS5B/EED/NOLC1/PRKDC/H2AX/ZW10/RPA2/ING3/POLD2/AK2/CDC25B/LBR/TK1/EZH2/CDK4/NOP56/NUP153/TIMELESS/RAD50/RAD51C/PTTG1/SMC1A/PPP1R8/CSE1L/SYNCRIP/CTCF/MRE11/POLD1/CNOT9/CHEK2/PRDX4/HMGB3/GINS4/NUP107/NUDT21/MYC/PSIP1/PHF5A/CTPS1/SRSF2/UBR7/DNMT1/NBN/SMC3/SNRPB/NCAPD2/UBR7/RNASEH2A/CDC20/PNN/CDKN3/UNG/WDR90/HMGA1/HMMR/STMN1/H2AZ1/NASP/ORC6/MTHFD2/KIF4A/PAICS/LYAR/PA2G4/RACGAP1/CCNB2/PRPS1/SRSF1/PSMC3IP/RANBP1/CKS1B/RFC2/STAG1/CHEK1/MSH2/TACC3/DEK/SPC25/AURKA/DDX39A/BARD1/NUP205/SSRP1/BIRC5/ASF1B/DLGAP5/BRCA2/POP7/USP1/SHMT1/DSCC1/PCNA/DUT/ATAD2/KIF2C/POLA2/CDCA3/CDCA8/DONSON/SPAG5/KIF22/RRM2/UBE2T/DCK/AURKB/DCLRE1B/TIPIN/EXOSC8/MXD3/MAD2L1/TRIP13/TUBB/DEPDC1/TUBB/MCM7/MKI67/CENPE/HMGB2/HNRNPD/TUBB/BRCA1/TUBB/PLK1/LIG1/CCNE1/TMPO/POLD3/TUBB/MCM6/SPC24/CIT/HELLS/GINS3/DIAPH3/RFC3/ANP32E/TCF19/NME1/TCF19/TUBB/TUBB/DCTPP1/TUBB/CDK1/TOP2A/MCM3/MCM2/TCF19/KIF18B/SUV39H1/LMNB1/TCF19/WEE1/TCF19/TCF19/MMS22L/TCF19/MELK/BUB1B/SPC25/MCM4/ESPL1/MYBL2/MCM5/CENPM/PLK4/CDC25A/RAD51AP1/E2F8/GINS1 HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 200 -0.452569654 -1.776450408 0.001264223 0.010442774 0.006595436 5802 "tags=55%, list=39%, signal=34%" DHX15/APEX1/PHB/MRPS18B/IFRD1/SMARCC1/ORC2/LDHA/CUL1/CBX3/GOT2/MRPS18B/GSPT1/KPNA2/PTGES3/EIF4E/MRPS18B/HDDC2/SNRPD3/PSMD14/CCT5/PSMD8/SNRPA1/HSPD1/PHB2/SNRPA/PPM1G/PSMB2/ABCE1/HNRNPR/TRA2B/GNL3/RAN/POLE3/C1QBP/VDAC1/HSPE1/ERH/DDX18/CNBP/MRPL9/SRPK1/SSBP1/SNRPG/NOLC1/NCBP1/MRPS18B/POLD2/U2AF1/TARDBP/UBA2/PRDX3/SRSF7/CDK4/PRPF31/NOP56/SSBP1/EIF1AX/LSM7/SYNCRIP/HNRNPA2B1/NHP2/CSTF2/MRPS18B/UBE2E1/CYC1/RRP9/MRPS18B/FBL/PRDX4/SET/EPRS1/SNRPD1/DDX21/MYC/LSM2/CTPS1/SRSF2/SF3B3/HNRNPA3/LSM2/SRSF3/LSM2/CDC20/MRPL23/NOP16/EIF2S2/BUB3/H2AZ1/PA2G4/HPRT1/HNRNPA1/SRM/SRSF1/RANBP1/MRPS18B/IARS1/DEK/LSM2/LSM2/USP1/TYMS/PCNA/TFDP1/DUT/RRM1/CAD/HDGF/LSM2/XPOT/MAD2L1/MCM7/HNRNPD/CCNA2/CDK2/MCM6/NME1/PRPS2/MCM2/RFC4/MCM4/MCM5/CDC45 HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT 197 -0.551644802 -2.160564201 0.001272265 0.010442774 0.006595436 4199 "tags=57%, list=28%, signal=41%" MT2A/CDC25B/EFNA5/LBR/EZH2/CDK4/AMD1/HSPA8/PTTG1/SMC1A/SYNCRIP/CTCF/NUP50/DBF4/ATF5/CDC7/HMGB3/SNRPD1/MYC/SRSF2/DKC1/PRMT5/CCNF/HOXC10/KMT5A/CDC20/CDKN3/BUB1/HMGA1/HMMR/STMN1/BUB3/UCK2/H2AZ1/DTYMK/NASP/ORC6/SAP30/KIF4A/RACGAP1/CCNB2/STIL/SRSF1/CKS1B/FBXO5/LIG3/STAG1/CHEK1/TACC3/TLE3/AURKA/DDX39A/BARD1/NEK2/BIRC5/KIF23/SLC38A1/BRCA2/TRAIP/TFDP1/INCENP/MARCKS/KIF2C/KIF11/POLA2/TPX2/NUSAP1/KNL1/NSD2/KIF22/AURKB/KIF20B/MAD2L1/PRC1/MKI67/TROAP/CENPE/HNRNPD/KIF15/NDC80/CENPF/PLK1/CENPA/UBE2C/TMPO/CCNA2/MCM6/TTK/SMC2/CDK1/POLQ/TOP2A/MCM3/MCM2/SUV39H1/LMNB1/SLC7A5/CHAF1A/PBK/SLC7A1/CDC6/ESPL1/MYBL2/E2F1/MCM5/EXO1/GINS2/PLK4/CDC25A/RAD54L/RBL1/CDC45/E2F2 HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE 194 -0.384277833 -1.499000828 0.001283697 0.010442774 0.006595436 2638 "tags=28%, list=18%, signal=24%" SEPTIN9/SMC3/ECT2/ARHGEF2/BUB1/KIF4A/FSCN1/ANLN/RACGAP1/KATNB1/CCNB2/GEMIN4/FBXO5/NET1/CNTRL/AURKA/LLGL1/NEK2/BIRC5/KIF23/DLGAP5/BRCA2/INCENP/MARCKS/KIF2C/KIF11/TPX2/NUSAP1/CEP72/TUBGCP3/KIF22/CDK5RAP2/ARHGAP10/KIF20B/PRC1/CENPE/KIF15/NDC80/CENPF/PLK1/SYNPO/BIN1/SAC3D1/ALMS1/PIF1/CENPJ/PCGF5/TTK/CDK1/TOP2A/LMNB1/KNTC1/SASS6/ESPL1/RAPGEF5/ARAP3/SHROOM1 HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY 160 -0.435898432 -1.673866339 0.001297017 0.010442774 0.006595436 3808 "tags=50%, list=26%, signal=38%" FKBP5/SNX24/FOXC1/RRP12/MAPT/SCARB1/TUBB2B/ELOVL5/RARA/MYC/MINDY1/NBL1/DHCR7/INPP5F/MICB/ENDOD1/BAG1/AKAP1/SEMA3B/MAPT/FHL2/XBP1/RBBP8/MICB/ITPK1/SIAH2/CELSR1/SFN/UNC119/PDLIM3/SLC37A1/KAZN/FRK/PAPSS2/ITPK1/GJA1/MYBBP1A/OLFM1/FKBP4/ABLIM1/FAM102A/GAB2/NXT1/PMAIP1/KLF4/PPIF/IL17RB/PEX11A/WWC1/DEPTOR/SVIL/ZNF185/MREG/HR/MPPED2/TSKU/BCL11B/ASB13/SLC7A5/RETREG1/SYNGR1/TBC1D30/NPY1R/RASGRP1/NAV2/SLC1A4/CALB2/DLC1/REEP1/CYP26B1/OLFML3/MYB/CISH/KCNK5/BCL2/DHRS3/STC2/CA12/CBFA2T3/SLC22A5/CLDN7/SULT2B1/INHBB/SLC1A1/CELSR2 HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE 148 -0.41063125 -1.55831171 0.001305483 0.010442774 0.006595436 3808 "tags=45%, list=26%, signal=34%" FKBP5/FOXC1/PERP/PTGER3/XRCC3/MAPT/SCARB1/ELOVL5/NBL1/DHCR7/LSR/NAB2/MICB/FABP5/RNASEH2A/BAG1/CDC20/SEMA3B/MAPT/ASS1/XBP1/RBBP8/MICB/ITPK1/SIAH2/SFN/MDK/HPRT1/PDLIM3/IDH2/STIL/FRK/PAPSS2/ITPK1/FGFR3/TSPAN13/OLFM1/SORD/FKBP4/PLXNB1/FAM102A/SNX10/NXT1/LLGL2/EMP2/HOMER2/KLF4/PPIF/KIF20A/IL17RB/NMU/HR/CD9/TOP2A/SLC7A5/CDC6/NPY1R/GINS2/IMPA2/PLK4/SLC1A4/SLC29A1/CYP26B1/MYB/CISH/KCNK5/BCL2/PLAC1/CA12/SLC22A5/SULT2B1/CELSR2 HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 57 -0.58245995 -1.905381016 0.001461988 0.010442774 0.006595436 5257 "tags=77%, list=36%, signal=50%" PES1/FARSA/LAS1L/HSPD1/GRWD1/BYSL/GNL3/HSPE1/DDX18/NDUFAF4/NOLC1/IMP4/WDR43/CDK4/NOP56/EXOSC5/RRP12/RRP9/UTP20/MYC/PRMT3/PPAN/RABEPK/MAP3K6/NOP16/UNG/PA2G4/SRM/WDR74/PUS1/PPRC1/SLC29A2/MYBBP1A/SORD/TMEM97/MRTO4/HK2/PLK1/DCTPP1/MCM4/MCM5/TCOF1/SLC19A1/PLK4 HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING 55 0.528254631 1.904139011 0.003174603 0.015082956 0.009526078 1259 "tags=27%, list=9%, signal=25%" CXCL1/CCL7/TNF/IL7/CXCL3/CXCL10/IL3RA/IL6/IRF1/STAT3/STAT2/CD14/IFNGR1/CD44/IRF9 HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION 90 0.387219569 1.514719043 0.003412969 0.015082956 0.009526078 5063 "tags=59%, list=34%, signal=39%" IGF2R/STX12/GBF1/ATP6V1H/ATP7A/DOP1A/SNAP23/ABCA1/VAMP3/STX16/CLCN3/GLA/COG2/TSG101/USO1/LAMP2/AP1G1/NAPA/VAMP7/CLN5/MON2/RER1/COPE/NAPG/SEC22B/STX7/STAM/MAPK1/RAB5A/RAB14/ARFGEF2/ADAM10/AP2M1/GOLGA4/AP2B1/CLTC/YKT6/RAB22A/ARCN1/SEC31A/COPB2/GOSR2/KIF1B/ARFIP1/CLTA/VPS4B/OCRL/VPS45/SCAMP1/RAB9A/SOD1/M6PR/SNX2/COPB1 HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE 108 0.441786977 1.807388841 0.003508772 0.015082956 0.009526078 852 "tags=16%, list=6%, signal=16%" CXCL8/CCL20/SELE/CCL7/MEFV/TNFRSF9/SERPINE1/CXCL10/CCL5/CCL5/NFKBIA/CDKN1A/IL6/CD70/IRF1/IRAK2/BTG2/F3/MXD1/NFKB1 HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION 137 -0.410430959 -1.543868194 0.003937008 0.015082956 0.009526078 3488 "tags=32%, list=24%, signal=24%" DHX16/FLNC/PBX2/PBX2/PBX2/VAV2/CD276/HRAS/GAMT/CX3CL1/HRAS/LAMA3/FSCN1/MDK/TSPAN4/ACTG1/CERCAM/PBX2/COL16A1/NECTIN1/CDH8/MMP2/MAP4K2/ITGB4/ADAM23/IRS1/ARHGEF6/LDLRAP1/CRAT/THY1/NEXN/SLC30A3/CDH15/ATP1A3/CALB2/FBN1/SPEG/SRC/MAPK11/KCNH2/ADAMTS5/LAYN/NRXN2/SIRPA/CLDN7/NRTN/ICAM4/DSC1 HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS 134 0.398599728 1.682938506 0.004149378 0.015082956 0.009526078 2001 "tags=30%, list=14%, signal=26%" TNF/BIRC3/SAT1/IER3/TXNIP/IER3/IER3/IER3/IER3/IER3/CDKN1A/BMF/CLU/IL6/IRF1/NEDD9/GADD45B/GPX3/MCL1/LGALS3/BTG2/CYLD/SATB1/PDCD4/ATF3/IGF2R/RETSAT/SPTAN1/SOD2/DNAJC3/CD14/IFNGR1/BNIP3L/CD44/PPP2R5B/BMP2/PSEN1/GADD45A/CASP9/MADD/JUN/RHOB/SQSTM1/ANXA1 HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE 141 0.400950641 1.703442877 0.004255319 0.015082956 0.009526078 1376 "tags=22%, list=9%, signal=20%" FCGR1A/CCL7/VAMP5/IL7/TNFAIP3/CXCL10/CCL5/CCL5/NFKBIA/VAMP8/TXNIP/CFB/CFB/CFB/CFB/CDKN1A/CFB/CFB/IL6/CFB/HLA-DMA/IRF1/HLA-DMA/TNFAIP2/DDX58/HLA-DMA/HLA-DMA/HLA-DMA/HLA-DMA/HLA-DMA/VCAM1/STAT3/STAT2/NFKB1/HLA-DMA/MVP/SOD2/BTG1/HELZ2/TOR1B/CCL2/IRF9/RIPK1/HLA-A HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB 158 0.646013891 2.757699267 0.004347826 0.015082956 0.009526078 2122 "tags=49%, list=14%, signal=42%" CCL20/CXCL1/CXCL2/TNFRSF9/TNF/CXCL3/SERPINE1/TNFAIP3/RELB/CXCL10/CCL5/CCL5/SDC4/BIRC3/FOS/NFKBIA/SAT1/IER3/IER3/IER3/IER3/IER3/IER3/JUNB/ZFP36/CD83/CDKN1A/FOSB/NFKB2/PNRC1/IL6/EFNA1/IL23A/PLAU/SERPINB8/IRF1/GEM/PPP1R15A/PHLDA1/TNC/TNFAIP2/DDX58/GADD45B/MCL1/BTG2/BCL3/F3/CEBPD/KDM6B/NR4A1/MXD1/ATF3/NFKB1/KLF10/MAFF/HES1/PER1/SOD2/CCNL1/BTG1/DRAM1/NFAT5/CCL2/BIRC2/CD44/DNAJB4/NR4A2/REL/BMP2/IL6ST/BCL6/TSC22D1/GADD45A/ABCA1/TGIF1/JUN/ID2/TIPARP/RHOB/SQSTM1/DUSP1/B4GALT1/RNF19B/RELA HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY 171 0.339906975 1.465374417 0.004524887 0.015082956 0.009526078 1482 "tags=23%, list=10%, signal=21%" RRAD/H1-2/FOS/SAT1/VAMP8/IER3/TXNIP/ABAT/IER3/IER3/IER3/VWA5A/IER3/IER3/H2AW/CDKN1A/NDRG1/MXD4/PPP1R15A/TSPYL2/CDKN2B/BTG2/OSGIN1/MXD1/ATF3/S100A10/MKNK2/TAX1BP3/ANKRA2/DCXR/BAIAP2/RETSAT/BTG1/DRAM1/EPHX1/ABCC5/EPS8L2/ZMAT3/CSRNP2/BMP2/IP6K2/TOB1/SESN1 HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP 142 0.33038024 1.399321738 0.017167382 0.045177321 0.028533045 1326 "tags=15%, list=9%, signal=14%" CXCL2/RRAD/EPCAM/FOS/NFKBIA/MAPK8IP2/FGF18/JUNB/FOSB/IL6/IRF1/GPX3/CDKN2B/BTG2/MSX1/NR4A1/NXF1/ATF3/ACAA1/SOD2/BTG1/APOM/EPHX1/AQP3/NAT1