##gff-version 3 chr1 CDS 1 1524 . + . ID=CDS1;locus_tag=Rv0001;product=Chromosomal replication initiator protein DnaA;note=FunctionalCategory: information pathways chr1 CDS 2052 3260 . + . ID=CDS1;locus_tag=Rv0002;product=DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase);note=FunctionalCategory: information pathways chr1 CDS 3280 4437 . + . ID=CDS1;locus_tag=Rv0003;product=DNA replication and repair protein RecF (single-strand DNA binding protein);note=FunctionalCategory: information pathways chr1 CDS 4434 4997 . + . ID=CDS1;locus_tag=Rv0004;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 5240 7267 . + . ID=CDS1;locus_tag=Rv0005;product=DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolyzing)) (DNA topoisomerase II) (type II DNA topoisomerase);note=FunctionalCategory: information pathways chr1 CDS 7302 9818 . + . ID=CDS1;locus_tag=Rv0006;product=DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolyzing)) (DNA topoisomerase II) (type II DNA topoisomerase);note=FunctionalCategory: information pathways chr1 CDS 9914 10828 . + . ID=CDS1;locus_tag=Rv0007;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 11874 12311 . - . ID=CDS1;locus_tag=Rv0008c;gene=cwsA;product=cell wall synthesis and cell shape protein A (CwsA);Experiment=DESCRIPTION:Bacterial two-hybrid protein-protein interaction assay, pull-down assay, qRT-PCR, measurement of cell wall turnover (using C14-labeling of N-acetylglucosamine), cell wall hydrolysis assay, deletion mutagenesis [PMID: 23002219]/note:FunctionalCategory: cell wall and cell processes/note:involved in septal Z-ring assembly and polar peptidoglycan synthesis [PMID: 23002219]/note:interacts with CrgA and Wag31 [PMID: 23002219]/note:forms complex with CrgA implicated in peptidoglycan synthesis and cell shape [PMID: 23002219] chr1 CDS 12486 13016 . + . ID=CDS1;locus_tag=Rv0009;product=Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 13133 13558 . - . ID=CDS1;locus_tag=Rv0010c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, bound and potentially regulated by cAMP-responsive protein (CRP) [PMID: 25940627] chr1 CDS 13714 13995 . - . ID=CDS1;locus_tag=Rv0011c;product=probable cell division protein CrgA;note=gene crgA;Experiment=DESCRIPTION:Bacterial two-hybrid protein-protein interaction assay, pull-down assay, qRT-PCR, measurement of cell wall turnover (using C14-labeling of N-acetylglucosamine), cell wall hydrolysis assay, deletion mutagenesis [PMID: 23002219],Experiment=DESCRIPTION:Bacterial two-hybrid protein-protein interaction assay, pull-down assay, immunoblotting, protein purification via elution [PMID: 21531798]/note:FunctionalCategory: cell wall and cell processes/note:involved in cell growth, cell wall synthesis, cell shape, viability/note:localizes at septa, at poles, on membranes [PMID:21531798]/note:probable FtsZ-interacting and peptidoglycan synthesis protein [PMID:21531798]/note:induced and exported in vivo [PMID: 28442606] chr1 CDS 14089 14877 . + . ID=CDS1;locus_tag=Rv0012;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 14914 15612 . + . ID=CDS1;locus_tag=Rv0013;product=Possible anthranilate synthase component II TrpG (glutamine amidotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 15590 17470 . - . ID=CDS1;locus_tag=Rv0014c;product=Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B);note=FunctionalCategory: regulatory proteins chr1 CDS 17467 18762 . - . ID=CDS1;locus_tag=Rv0015c;product=Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A);note=FunctionalCategory: regulatory proteins chr1 CDS 18759 20234 . - . ID=CDS1;locus_tag=Rv0016c;product=Probable penicillin-binding protein PbpA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 20231 21640 . - . ID=CDS1;locus_tag=Rv0017c;product=Probable cell division protein RodA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 21637 23181 . - . ID=CDS1;locus_tag=Rv0018c;product=Phosphoserine/threonine phosphatase PstP;note=FunctionalCategory: regulatory proteins chr1 CDS 23270 23737 . - . ID=CDS1;locus_tag=Rv0019c;gene=fipA;product=FtsZ-interacting protein A, FipA;Experiment=DESCRIPTION:Gene knockout and complementation study, intramacrophagal growth assay, cell lysate co-immunoprecipitation, in vitro kinase assay [PMID: 20066037]/note:FunctionalCategory: regulatory proteins/note:Interacts with membrane proteins PapA5, GtsQ, and FtsZ [PMID: 19826007]/note:Forms a ternary complex with FtsZ and FtsQ, the formation of which is PknA-phosphorylation dependent [PMID: 20066037]/note:Likely involved in regulating cell division under oxidative stress [PMID: 20066037]/note:Possibly involved in the regulation of PDIM biosynthesis [PMID: 20487298] chr1 CDS 23861 25444 . - . ID=CDS1;locus_tag=Rv0020c;gene=fhaA;product=Probable Cell wall synthesis protein with FHA domain, FhaA;Experiment=DESCRIPTION:X-ray Crystallography, mass spectrometry, isothermal titration calorimetry, protein fragment complementation assay, gene knockdown [PMID: 22275220]/note:FunctionalCategory: regulatory proteins/note:Bound by malate dehydrogenase in phosphothreonine-dependent manner [PMID: 25860441]/note:Knockdown of FhaA in M.smegmatis alters cell wall morphology and causes misregulation of peptidoglycan synthesis [PMID: 22275220]/note:Phosphorylated by PknB and PknF [PMID: 22000520,15987910]/note:Co-expressed with PknA and PknB [PMID: 15987910]/note:Recruited to the phosphorylated pseudokinase domain in MviN, an essential membrane protein important for peptidoglycan biosynthesis [PMID: 22275220]/note:Induced on the down regulation of Rv2159c [PMID: 27818650] chr1 CDS 25913 26881 . - . ID=CDS1;locus_tag=Rv0021c;product=putative nitronate monooxygenase, Putative Enoyl-[acyl-carrier-protein] reductase (NADH).;Experiment=DESCRIPTION:recombinant DNA expression, enzyme activity assay and inhibition assay for homolog [PMID: 23408846]/note:FunctionalCategory: conserved hypotheticals;EC_number=1.13.12.16,EC_number=1.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1vrdA,4mz1A,4zqmA,2cu0A,4af0A,4q33A,1nf7A,3r2gA,4xtdA,3khjH,3tsbA,1me7A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.3.1.9 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4iqlA,3bo9A,2z6iB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0003938/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,4mz1A,4zqmA,2cu0A,4af0A,1nf7A,3tsbA,4xtdA,3r2gA,1me7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,4mz1A,4zqmA,2cu0A,4af0A,1nf7A,3tsbA,4xtdA,3r2gA,1me7A,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 1nf7A,1me7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,1me7A,Ontology_term=1904813/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0060041/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0046651/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0009168/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,4mz1A,4zqmA,2cu0A,4af0A,4q33A,1nf7A,3tsbA,4xtdA,3khjH,3r2gA,1me7A,2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,4mz1A,4zqmA,2cu0A,4af0A,4q33A,1nf7A,3tsbA,4xtdA,3khjH,3r2gA,1me7A,2z6iB,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,4af0A,1nf7A,1me7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,4af0A,1nf7A,1me7A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0005778/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0071353/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,4af0A,1nf7A,3tsbA,1me7A,4iqlA,2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,4af0A,1nf7A,3tsbA,1me7A,4iqlA,2z6iB,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0006183/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,1nf7A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,2cu0A,4af0A,1nf7A,3tsbA,1me7A,2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,2cu0A,4af0A,1nf7A,3tsbA,1me7A,2z6iB,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1me7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1me7A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,4mz1A,4zqmA,2cu0A,4af0A,4q33A,1nf7A,3tsbA,4xtdA,3khjH,3r2gA,1me7A,4iqlA,3bo9A,2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,4mz1A,4zqmA,2cu0A,4af0A,4q33A,1nf7A,3tsbA,4xtdA,3khjH,3r2gA,1me7A,4iqlA,3bo9A,2z6iB,Ontology_term=0034774/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0018580/note:identified by similarity of predicted tertiary structure to PDB 4iqlA,3bo9A,2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iqlA,3bo9A,2z6iB,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,4mz1A,4zqmA,2cu0A,4af0A,4q33A,1nf7A,3tsbA,4xtdA,3khjH,3r2gA,1me7A,4iqlA,3bo9A,2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,4mz1A,4zqmA,2cu0A,4af0A,4q33A,1nf7A,3tsbA,4xtdA,3khjH,3r2gA,1me7A,4iqlA,3bo9A,2z6iB,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 1me7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1me7A,Ontology_term=0006177/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,2cu0A,4af0A,1nf7A,3tsbA,1me7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,2cu0A,4af0A,1nf7A,3tsbA,1me7A,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z6iB,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0043312/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1nf7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nf7A,Ontology_term=0006164/note:identified by similarity of predicted tertiary structure to PDB 1vrdA,4mz1A,4zqmA,2cu0A,4af0A,1nf7A,3tsbA,4xtdA,1me7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vrdA,4mz1A,4zqmA,2cu0A,4af0A,1nf7A,3tsbA,4xtdA,1me7A,Ontology_term=0004318/note:identified by similarity of predicted tertiary structure to PDB 2z6iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z6iB chr1 CDS 27023 27442 . - . ID=CDS1;locus_tag=Rv0022c;product=Probable transcriptional regulatory protein WhiB-like WhiB5;note=FunctionalCategory: regulatory proteins chr1 CDS 27595 28365 . + . ID=CDS1;locus_tag=Rv0023;product=Possible transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 28362 29207 . + . ID=CDS1;locus_tag=Rv0024;product=Probable peptidoglycan hydrolase;Experiment=DESCRIPTION:in vitro growth assessment, biofilm formation assay (confocal scanning microscopy), cell adhesion assay, hydrophobicity assay, intracellular survival assay, invasion assay [PMID: 26706821]/inference:alignment:ClustalW [PMID: 26706821]/note:FunctionalCategory: virulence, detoxification, adaptation/note:induces biofilm formation, surface hydrophobicity, and adherence to lung epithelial cell when expressed in M. smegmatis [PMID: 26706821]/note:associated with resistance to isoniazid and pyrazinamide [PMID: 26706821]/note:belongs to the NlpC/p60 protein family [PMID: 26706821];EC_number=3.4.-.- chr1 CDS 29245 29607 . + . ID=CDS1;locus_tag=Rv0025;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 29722 31068 . + . ID=CDS1;locus_tag=Rv0026;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 31189 31506 . + . ID=CDS1;locus_tag=Rv0027;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 31514 31819 . + . ID=CDS1;locus_tag=Rv0028;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 32057 33154 . + . ID=CDS1;locus_tag=Rv0029;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 33224 33553 . + . ID=CDS1;locus_tag=Rv0030;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 33582 33794 . + . ID=CDS1;locus_tag=Rv0031;product=Possible remnant of a transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 34202 36610 . + . ID=CDS1;locus_tag=Rv0032;product=Possible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 36607 36870 . + . ID=CDS1;locus_tag=Rv0033;product=Probable acyl carrier protein AcpA (ACP);note=FunctionalCategory: lipid metabolism chr1 CDS 36867 37262 . + . ID=CDS1;locus_tag=Rv0034;product=Putative ether hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.3.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bngC,5aifA,5aihA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004301/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0033963/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0097176/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC chr1 CDS 37259 38947 . + . ID=CDS1;locus_tag=Rv0035;product=Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 39056 39829 . - . ID=CDS1;locus_tag=Rv0036c;product=Conserved protein/putative thiol-dependent DinB-like metalloenzyme;note=FunctionalCategory: conserved hypotheticals, identified by similarity of predicted tertiary structure to PDB 2nsgA,2nsfA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsgA,2nsfA/note:Shares the four-helix up-down-down-up bundle, salt-bridge domain-linking residues, metal-coordinating histidine triad, and predicted metal-binding site characteristic of DinB family metalloenzymes/note:Has the thiol-interacting Trp and Arg residues of the catalytic center conserved/note:potential mycothiol-dependent S-transferase (EC 2.-.-.-) chr1 CDS 39877 41202 . - . ID=CDS1;locus_tag=Rv0037c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes, putatively belongs to the MFS (major facilitator superfamily) type transporter [PMID: 12520088], in silico protein-protein interaction network suggest this to be an efflux pump [PMID: 22132058], overexpressed in rifampicin resistant clinical isolates [PMID: 25690361], potential Transmembrane transporter, identified by similarity of predicted tertiary structure to PDB 3wdoA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wdoA chr1 CDS 41304 41912 . + . ID=CDS1;locus_tag=Rv0038;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, structural homolog of UPF0301 protein VC_0467, identified by similarity of predicted tertiary structure to PDB 2hafA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hafA chr1 CDS 42004 42351 . - . ID=CDS1;locus_tag=Rv0039c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 42433 43365 . - . ID=CDS1;locus_tag=Rv0040c;gene=mtc28;product=Probable PsbP and Ran-binding protein (Mog1p) Mtc28/Antigen;Experiment=DESCRIPTION:HPLC, X-ray crystallography, structural determination using MIRAS, MALDI-TOF MS, ELISA, antibody-binding inhibition assay, deletion mutagenesis [PMID: 27189947]/note:FunctionalCategory: cell wall and cell processes/note:proline rich 28 kDa antigen [TubercuList]/note:predicted to be specific to Mycobacterium tuberculosis and not found in other mycobacterial species (M. leprae not tested) [PMID: 9393781] chr1 CDS 43562 46471 . + . ID=CDS1;locus_tag=Rv0041;product=Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 46581 47207 . - . ID=CDS1;locus_tag=Rv0042c;product=Possible transcriptional regulatory protein (probably MarR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 47366 48100 . - . ID=CDS1;locus_tag=Rv0043c;product=Probable transcriptional regulatory protein (probably GntR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 48233 49027 . - . ID=CDS1;locus_tag=Rv0044c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 49043 49939 . - . ID=CDS1;locus_tag=Rv0045c;product=Possible hydrolase;note=FunctionalCategory: lipid metabolism chr1 CDS 50021 51124 . - . ID=CDS1;locus_tag=Rv0046c;product=myo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 51185 51727 . - . ID=CDS1;locus_tag=Rv0047c;product=Conserved protein/Putative transcriptional regulator;note=FunctionalCategory: conserved hypotheticals, Strong homology to two padR family transcriptional regulatory proteins, identified by similarity of predicted tertiary structure to PDB 1yg2a,3l9fA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yg2a,3l9fA chr1 CDS 51828 52697 . - . ID=CDS1;locus_tag=Rv0048c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 52831 53244 . + . ID=CDS1;locus_tag=Rv0049;product=Conserved hypothetical protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:07408 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:potential involvement in membrane associated processes chr1 CDS 53663 55699 . + . ID=CDS1;locus_tag=Rv0050;product=Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 55696 57378 . + . ID=CDS1;locus_tag=Rv0051;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 57410 57973 . + . ID=CDS1;locus_tag=Rv0052;product=putative hydro-lyase/putative deglycase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3b38A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3b38A/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3nooA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 58192 58482 . + . ID=CDS1;locus_tag=Rv0053;product=30S ribosomal protein S6 RpsF;note=FunctionalCategory: information pathways chr1 CDS 58586 59080 . + . ID=CDS1;locus_tag=Rv0054;product=Single-strand binding protein Ssb (helix-destabilizing protein);note=FunctionalCategory: information pathways chr1 CDS 59122 59376 . + . ID=CDS1;locus_tag=Rv0055;product=30S ribosomal protein S18-1 RpsR1;note=FunctionalCategory: information pathways chr1 CDS 59409 59867 . + . ID=CDS1;locus_tag=Rv0056;product=50S ribosomal protein L9 RplI;note=FunctionalCategory: information pathways chr1 CDS 59896 60417 . + . ID=CDS1;locus_tag=Rv0057;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 60396 63020 . + . ID=CDS1;locus_tag=Rv0058;product=Probable replicative DNA helicase DnaB;note=FunctionalCategory: information pathways chr1 CDS 63200 63892 . + . ID=CDS1;locus_tag=Rv0059;product=Probable toxin DarT/Probable DNA ADP-ribosyl transferase;Experiment=DESCRIPTION:Protein purification and expression in E. coli, Toxicitiy assays, De-ADP-Ribosylation Assays, HPLC, quadrupole-time-of-flight mass spectrometry [PMID: 27939941]/note:FunctionalCategory: conserved hypotheticals/note:Part of a toxin-antitoxin system with Rv0060 [PMID: 27939941] chr1 CDS 63909 64967 . + . ID=CDS1;locus_tag=Rv0060;product=Probable antitoxin DarG/Probable DNA ADP-ribosyl glycohydrolase;Experiment=DESCRIPTION:Protein purification and expression in E. coli, Toxicitiy assays, De-ADP-Ribosylation Assays, HPLC, quadrupole-time-of-flight mass spectrometry [PMID: 27939941]/note:FunctionalCategory: conserved hypotheticals/note:Part of a toxin-antitoxin system with Rv0059 [PMID: 27939941] chr1 CDS 65012 65350 . - . ID=CDS1;locus_tag=Rv0061c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 65552 66694 . + . ID=CDS1;locus_tag=Rv0062;product=Possible cellulase CelA1 (endoglucanase) (endo-1,4-beta-glucanase) (FI-cmcase) (carboxymethyl cellulase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 66923 68362 . + . ID=CDS1;locus_tag=Rv0063;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 68620 71559 . + . ID=CDS1;locus_tag=Rv0064;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 71589 71828 . + . ID=CDS1;locus_tag=Rv0064A;product=Possible antitoxin VapB1;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 71821 72222 . + . ID=CDS1;locus_tag=Rv0065;product=Possible toxin VapC1;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 72274 74511 . - . ID=CDS1;locus_tag=Rv0066c;product=Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 74629 75198 . - . ID=CDS1;locus_tag=Rv0067c;product=Possible transcriptional regulatory protein (possibly TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 75301 76212 . + . ID=CDS1;locus_tag=Rv0068;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 76237 77622 . - . ID=CDS1;locus_tag=Rv0069c;product=Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 77619 78896 . - . ID=CDS1;locus_tag=Rv0070c;product=Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 79486 80193 . + . ID=CDS1;locus_tag=Rv0071;product=Possible maturase;note=FunctionalCategory: information pathways chr1 CDS 80624 81673 . + . ID=CDS1;locus_tag=Rv0072;product=Probable glutamine-transport transmembrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 81676 82668 . + . ID=CDS1;locus_tag=Rv0073;product=Probable glutamine-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 82748 83983 . + . ID=CDS1;locus_tag=Rv0074;product=Conserved protein/Putative amide hydrolase/Putative C-halide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4c5yA,1v4yA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.5.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2gokA,2oofA,2g3fA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.8.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4v1xA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0019381/note:identified by similarity of predicted tertiary structure to PDB 4v1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4v1xA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2gokA,2oofA,2g3fA,4v1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gokA,2oofA,2g3fA,4v1xA,Ontology_term=0006547/note:identified by similarity of predicted tertiary structure to PDB 2gokA,2oofA,2g3fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gokA,2oofA,2g3fA,Ontology_term=0016805/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0102009/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4c5yA,1v4yA,2gokA,2oofA,2g3fA,4v1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,1v4yA,2gokA,2oofA,2g3fA,4v1xA,Ontology_term=0018788/note:identified by similarity of predicted tertiary structure to PDB 4v1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4v1xA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4c5yA,1v4yA,2gokA,2oofA,2g3fA,4v1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,1v4yA,2gokA,2oofA,2g3fA,4v1xA,Ontology_term=1900817/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0047420/note:identified by similarity of predicted tertiary structure to PDB 1v4yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1v4yA,Ontology_term=0016812/note:identified by similarity of predicted tertiary structure to PDB 2gokA,2oofA,2g3fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gokA,2oofA,2g3fA,Ontology_term=0016810/note:identified by similarity of predicted tertiary structure to PDB 4c5yA,1v4yA,2gokA,2oofA,2g3fA,4v1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,1v4yA,2gokA,2oofA,2g3fA,4v1xA,Ontology_term=0050480/note:identified by similarity of predicted tertiary structure to PDB 2gokA,2oofA,2g3fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gokA,2oofA,2g3fA,Ontology_term=0019556/note:identified by similarity of predicted tertiary structure to PDB 2gokA,2oofA,2g3fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gokA,2oofA,2g3fA,Ontology_term=0019557/note:identified by similarity of predicted tertiary structure to PDB 2gokA,2oofA,2g3fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gokA,2oofA,2g3fA chr1 CDS 83996 85168 . + . ID=CDS1;locus_tag=Rv0075;product=Probable aminotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 85183 85572 . - . ID=CDS1;locus_tag=Rv0076c;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 85636 86466 . - . ID=CDS1;locus_tag=Rv0077c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 86528 87133 . + . ID=CDS1;locus_tag=Rv0078;product=Probable transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 87208 87801 . - . ID=CDS1;locus_tag=Rv0078A;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, modest structural similarity with known nucleotidyltransferase, possible nucleotidyltransferase, identified by similarity of predicted tertiary structure to PDB:4ok0A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ok0A chr1 CDS 87798 88004 . - . ID=CDS1;locus_tag=Rv0078B;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 88204 89025 . + . ID=CDS1;locus_tag=Rv0079;product=Putative Dormancy Associated Translation Inhibitor (DATIN);note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:in vitro overexpression in M.bovis and E.coli[PMID:22719925],Experiment=s using PatchDock [PMID:22719925]/note:induces inflammatory cytokines in macrophage [PMID: 23819907]/note:interacts with TLR2 [PMID: 23819907]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 89022 89480 . + . ID=CDS1;locus_tag=Rv0080;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 89575 89919 . + . ID=CDS1;locus_tag=Rv0081;product=Probable transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 89924 90403 . + . ID=CDS1;locus_tag=Rv0082;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 90400 92322 . + . ID=CDS1;locus_tag=Rv0083;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 92328 93278 . + . ID=CDS1;locus_tag=Rv0084;product=Possible formate hydrogenlyase HycD (FHL);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 93289 93951 . + . ID=CDS1;locus_tag=Rv0085;product=Possible hydrogenase HycP;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 93951 95417 . + . ID=CDS1;locus_tag=Rv0086;product=Possible hydrogenase HycQ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 95414 96892 . + . ID=CDS1;locus_tag=Rv0087;product=Possible formate hydrogenase HycE (FHL);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 96927 97601 . + . ID=CDS1;locus_tag=Rv0088;product=Possible polyketide cyclase/dehydrase;note=FunctionalCategory: lipid metabolism chr1 CDS 97758 98351 . + . ID=CDS1;locus_tag=Rv0089;product=Possible methyltransferase/methylase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 98480 99250 . + . ID=CDS1;locus_tag=Rv0090;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 99684 100451 . + . ID=CDS1;locus_tag=Rv0091;product=Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 100583 102868 . + . ID=CDS1;locus_tag=Rv0092;product=Cation transporter P-type ATPase a CtpA;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 102815 103663 . - . ID=CDS1;locus_tag=Rv0093c;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 103710 104663 . - . ID=CDS1;locus_tag=Rv0094c;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 104805 105215 . - . ID=CDS1;locus_tag=Rv0095c;product=Conserved hypothetical protein;Experiment=DESCRIPTION:ChIP-seq [PMID: 22528497]/note:FunctionalCategory: insertion seqs and phages/note:Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 22528497] chr1 CDS 105324 106715 . + . ID=CDS1;locus_tag=Rv0096;gene=PPE1;product=PPE family protein PPE1;Experiment=EXISTENCE: Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 106734 107603 . + . ID=CDS1;locus_tag=Rv0097;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 107600 108151 . + . ID=CDS1;locus_tag=Rv0098;product=Probable fatty acyl CoA thioesterase type III FcoT;note=FunctionalCategory: lipid metabolism chr1 CDS 108156 109778 . + . ID=CDS1;locus_tag=Rv0099;product=Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 109783 110019 . + . ID=CDS1;locus_tag=Rv0100;product=acyl carrier protein;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:protein purification and characterization, enzymatic assays to detect acylation, HPLC-MS [PMID: 23625916] chr1 CDS 110001 117539 . + . ID=CDS1;locus_tag=Rv0101;product=Probable peptide synthetase Nrp (peptide synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 117714 119699 . + . ID=CDS1;locus_tag=Rv0102;product=Probable conserved integral membrane protein;Experiment=DESCRIPTION:mass spectrometry, cDNA synthesis, qPCR, microarray analysis under hypoxia [PMID: 23853579]/note:FunctionalCategory: cell wall and cell processes/note:involved in hypoxia [PMID: 23853579]/note:reduced expression in response to mamA methylation [PMID: 23853579] chr1 CDS 119915 122173 . - . ID=CDS1;locus_tag=Rv0103c;product=Probable cation-transporter P-type ATPase B CtpB;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 122317 123831 . + . ID=CDS1;locus_tag=Rv0104;product=Probable CRP binding protein;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:In vivo DNA binding in M. bovis using chromatin immunoprecipitation, EMSA, beta-galactosidase assays, ChIP-seq [PMID: 25940627] chr1 CDS 123980 124264 . - . ID=CDS1;locus_tag=Rv0105c;product=50S ribosomal protein L28-1 RpmB1;note=FunctionalCategory: information pathways chr1 CDS 124374 125570 . + . ID=CDS1;locus_tag=Rv0106;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 125643 127304 . - . ID=CDS1;locus_tag=Rv0107c;product=Probable cation-transporter ATPase I CtpI;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 130895 131104 . - . ID=CDS1;locus_tag=Rv0108c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 131382 132872 . + . ID=CDS1;locus_tag=Rv0109;gene=PE_PGRS1;product=PE-PGRS family protein PE_PGRS1;Experiment=EXISTENCE: Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 133020 133769 . + . ID=CDS1;locus_tag=Rv0110;product=Putative rhomboid protease 1;Experiment=DESCRIPTION:complementation of known ortholog in M.smegmatis [PMID: 23029216]/note:FunctionalCategory: cell wall and cell processes;Inference=alignment:ClustalW, MUSCLE [PMID: 21029479];EC_number=3.4.21.105 chr1 CDS 133950 136007 . + . ID=CDS1;locus_tag=Rv0111;product=Possible transmembrane acyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 136289 137245 . + . ID=CDS1;locus_tag=Rv0112;product=Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 137319 137909 . + . ID=CDS1;locus_tag=Rv0113;product=Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 137941 138513 . + . ID=CDS1;locus_tag=Rv0114;product=Possible D-alpha,beta-D-heptose-1,7-biphosphate phosphatase GmhB (D-glycero-D-manno-heptose 7-phosphate kinase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 138513 139673 . + . ID=CDS1;locus_tag=Rv0115;product=Possible D-alpha-D-heptose-7-phosphate kinase HddA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 140267 141022 . - . ID=CDS1;locus_tag=Rv0116c;product=Probable L,D-transpeptidase LdtA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 141200 142144 . + . ID=CDS1;locus_tag=Rv0117;product=Oxidative stress response regulatory protein OxyS;note=FunctionalCategory: regulatory proteins chr1 CDS 142128 143876 . - . ID=CDS1;locus_tag=Rv0118c;product=Probable oxalyl-CoA decarboxylase OxcA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 144049 145626 . + . ID=CDS1;locus_tag=Rv0119;product=Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 145627 147771 . - . ID=CDS1;locus_tag=Rv0120c;product=Probable elongation factor G FusA2 (EF-G);note=FunctionalCategory: information pathways chr1 CDS 147908 148342 . - . ID=CDS1;locus_tag=Rv0121c;product=Conserved protein/Probable Pyridoxal 5'-phosphate synthase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.4.3.5 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4zkyA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 4zkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zkyA chr1 CDS 148491 148859 . + . ID=CDS1;locus_tag=Rv0122;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 148856 149224 . + . ID=CDS1;locus_tag=Rv0123;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 149533 150996 . + . ID=CDS1;locus_tag=Rv0124;gene=PE_PGRS2;product=PE-PGRS family protein PE_PGRS2;Experiment=EXISTENCE: Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 151148 152215 . + . ID=CDS1;locus_tag=Rv0125;product=Probable serine protease PepA (serine proteinase) (MTB32A);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 152324 154129 . + . ID=CDS1;locus_tag=Rv0126;product=Trehalose synthase TreS;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 154232 155599 . + . ID=CDS1;locus_tag=Rv0127;product=Maltokinase Mak;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 155667 156446 . + . ID=CDS1;locus_tag=Rv0128;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 156578 157600 . - . ID=CDS1;locus_tag=Rv0129c;product=Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C);note=FunctionalCategory: lipid metabolism chr1 CDS 157847 158302 . + . ID=CDS1;locus_tag=Rv0130;product=Probable 3-hydroxyl-thioester dehydratase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 158315 159619 . - . ID=CDS1;locus_tag=Rv0131c;product=Probable acyl-CoA dehydrogenase FadE1;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 159700 160782 . - . ID=CDS1;locus_tag=Rv0132c;product=Putative F420-dependent glucose-6-phosphate dehydrogenase Fgd2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 160869 161474 . + . ID=CDS1;locus_tag=Rv0133;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 161771 162673 . + . ID=CDS1;locus_tag=Rv0134;product=Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 162644 163249 . - . ID=CDS1;locus_tag=Rv0135c;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0019217/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 5dxzA,3vprA,3himB,2ibdA,4g12A,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dxzA,3vprA,3himB,2ibdA,4g12A,4w97A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 5dxzA,3vprA,3himB,2ibdA,4g12A,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dxzA,3vprA,3himB,2ibdA,4g12A,4w97A,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 5dxzA,3vprA,3himB,2ibdA,4g12A,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dxzA,3vprA,3himB,2ibdA,4g12A,4w97A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 5dxzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dxzA,Ontology_term=0010468/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3vprA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vprA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 4w97A,2ibdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,2ibdA chr1 CDS 163366 164691 . + . ID=CDS1;locus_tag=Rv0136;product=Probable cytochrome P450 138 Cyp138;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 164712 165260 . - . ID=CDS1;locus_tag=Rv0137c;product=Probable peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide reductase) (peptide met(O) reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 165323 165826 . + . ID=CDS1;locus_tag=Rv0138;product=Conserved hypothetical protein;Experiment=DESCRIPTION:2D gel electrophoresis, MALDI-TOF MS, western blotting, IFN-gamma blood test/note:FunctionalCategory: conserved hypotheticals/note:Probable antigen for diagnosis of tuberculosis[PMID: 19641100] chr1 CDS 165827 166849 . + . ID=CDS1;locus_tag=Rv0139;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 166910 167290 . + . ID=CDS1;locus_tag=Rv0140;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 167271 167681 . - . ID=CDS1;locus_tag=Rv0141c;product=Unknown protein/Putative ether hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.3.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bngC,1nu3B,5aifA,5aihA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004301/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0018744/note:identified by similarity of predicted tertiary structure to PDB 1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nu3B,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bngC,1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,1nu3B,Ontology_term=0033963/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0097176/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC chr1 CDS 167711 168637 . + . ID=CDS1;locus_tag=Rv0142;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 168704 170182 . - . ID=CDS1;locus_tag=Rv0143c;product=Probable conserved transmembrane protein/putative ion transport protein;note=FunctionalCategory: cell wall and cell processes;Ontology_term=0043168/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0015297/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0015706/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=1902600/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=1902476/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,3nd0A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3orgA,1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3orgA,1kpkA,3nd0A,Ontology_term=0015299/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0005247/note:identified by similarity of predicted tertiary structure to PDB 3orgA,1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3orgA,1kpkA,3nd0A,Ontology_term=0031404/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0055085/note:identified by similarity of predicted tertiary structure to PDB 3orgA,1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3orgA,1kpkA,3nd0A,Ontology_term=0034220/note:identified by similarity of predicted tertiary structure to PDB 1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,3nd0A,Ontology_term=0006821/note:identified by similarity of predicted tertiary structure to PDB 3orgA,1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3orgA,1kpkA,3nd0A,Ontology_term=0005887/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,3nd0A,Ontology_term=0006811/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0015108/note:identified by similarity of predicted tertiary structure to PDB 1kpkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,Ontology_term=0005216/note:identified by similarity of predicted tertiary structure to PDB 3orgA,1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3orgA,1kpkA,3nd0A,Ontology_term=1903959/note:identified by similarity of predicted tertiary structure to PDB 1kpkA,3nd0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kpkA,3nd0A chr1 CDS 170284 171126 . + . ID=CDS1;locus_tag=Rv0144;product=Probable transcriptional regulatory protein (possibly TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 171215 172168 . + . ID=CDS1;locus_tag=Rv0145;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 172211 173143 . + . ID=CDS1;locus_tag=Rv0146;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 173238 174758 . + . ID=CDS1;locus_tag=Rv0147;product=Probable aldehyde dehydrogenase (NAD+) dependent;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 174833 175693 . + . ID=CDS1;locus_tag=Rv0148;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 175700 176668 . + . ID=CDS1;locus_tag=Rv0149;product=Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 176665 176952 . - . ID=CDS1;locus_tag=Rv0150c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 177543 179309 . - . ID=CDS1;locus_tag=Rv0151c;gene=PE1;product=PE family protein PE1;Experiment=EXISTENCE: Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection. [PMID: 21085642] chr1 CDS 179319 180896 . - . ID=CDS1;locus_tag=Rv0152c;gene=PE2;product=PE family protein PE2;note=FunctionalCategory: PE/PPE chr1 CDS 181155 181985 . - . ID=CDS1;locus_tag=Rv0153c;product=Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase);note=FunctionalCategory: regulatory proteins chr1 CDS 181987 183198 . - . ID=CDS1;locus_tag=Rv0154c;product=Probable acyl-CoA dehydrogenase FadE2;note=FunctionalCategory: lipid metabolism chr1 CDS 183622 184722 . + . ID=CDS1;locus_tag=Rv0155;product=Probable NAD(P) transhydrogenase (subunit alpha) PntAa [first part/ catalytic part] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 184723 185055 . + . ID=CDS1;locus_tag=Rv0156;product=Probable NAD(P) transhydrogenase (subunit alpha) PntAb [second part/ integral membrane protein] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 185052 186479 . + . ID=CDS1;locus_tag=Rv0157;product=Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 186495 186623 . - . ID=CDS1;locus_tag=Rv0157A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 186785 187429 . + . ID=CDS1;locus_tag=Rv0158;product=Probable transcriptional regulatory protein (possibly TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 187433 188839 . - . ID=CDS1;locus_tag=Rv0159c;gene=PE3;product=PE family protein PE3;Experiment=EXISTENCE: label-free quantitative proteomics, mass spectrometry. [PMID: 21261938]/note:FunctionalCategory: PE/PPE/note:Modulate host immune response and enhance mycobacterial persistence during infection. [PMID: 23708146]/note:Induces Th1 type immune responses in mice [PMID: 23708146]/note:potential cytochrome oxidoreductase chr1 CDS 188931 190439 . - . ID=CDS1;locus_tag=Rv0160c;gene=PE4;product=Immunodominant antigen;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642],Experiment=DESCRIPTION:Protein expression and purification, In vivo infection, real-time PCR quantification, cell culture, ELISA, histopathology.[PMID: 23104642]/note:FunctionalCategory: PE/PPE/note:Improves host pathogenicity and virulence. [PMID: 23104642]/note:Expressed during Mycobacterium Tuberculosis infection and involved in Mycobacterium Tuberculosis's survival under stress condition induced by low pH and oxygen concentration (hypoxia). [PMID: 23104642]/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection. [PMID: 21085642] chr1 CDS 190607 191956 . + . ID=CDS1;locus_tag=Rv0161;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 191984 193135 . - . ID=CDS1;locus_tag=Rv0162c;product=Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 193117 193572 . + . ID=CDS1;locus_tag=Rv0163;product=Conserved protein/Putative thiolester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2oiwC,1lo8A,2cyeC,4k00A,1yliB,2ownB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006633/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 1yliB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yliB,Ontology_term=0006637/note:identified by similarity of predicted tertiary structure to PDB 1yliB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yliB,Ontology_term=0016790/note:identified by similarity of predicted tertiary structure to PDB 4k00A,2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,2ownB,Ontology_term=0042372/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,Ontology_term=0004320/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016290/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,Ontology_term=0004778/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1lo8A,4k00A,1yliB,2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lo8A,4k00A,1yliB,2ownB,Ontology_term=0047617/note:identified by similarity of predicted tertiary structure to PDB 4k00A,1yliB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,1yliB,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1yliB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yliB,Ontology_term=0016295/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016296/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016297/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0018739/note:identified by similarity of predicted tertiary structure to PDB 1lo8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lo8A chr1 CDS 193626 194111 . + . ID=CDS1;locus_tag=Rv0164;product=Probable antigen;Experiment=DESCRIPTION:Indirect ELISA [PMID: 28337993],Experiment=DESCRIPTION:Enzyme-linked immunosorbent assay (ELISA), antigen expression and purification [PMID:15019734]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to induce IFN-γ production (evidence based on ELISA) [PMID:15019734] chr1 CDS 194144 194815 . - . ID=CDS1;locus_tag=Rv0165c;product=Probable transcriptional regulatory protein Mce1R (probably GntR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 194993 196657 . + . ID=CDS1;locus_tag=Rv0166;product=Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 196861 197658 . + . ID=CDS1;locus_tag=Rv0167;gene=yrbE1A;product=Conserved integral membrane protein YrbE1A;note=FunctionalCategory: virulence, detoxification, adaptation;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 197660 198529 . + . ID=CDS1;locus_tag=Rv0168;gene=yrbE1B;product=Conserved integral membrane protein YrbE1B;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 198534 199898 . + . ID=CDS1;locus_tag=Rv0169;product=Mce-family protein Mce1A;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 199895 200935 . + . ID=CDS1;locus_tag=Rv0170;product=Mce-family protein Mce1B;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 200932 202479 . + . ID=CDS1;locus_tag=Rv0171;product=Mce-family protein Mce1C;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 202476 204068 . + . ID=CDS1;locus_tag=Rv0172;product=Mce-family protein Mce1D;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 204065 205237 . + . ID=CDS1;locus_tag=Rv0173;product=Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E);note=FunctionalCategory: cell wall and cell processes chr1 CDS 205231 206778 . + . ID=CDS1;locus_tag=Rv0174;product=Mce-family protein Mce1F;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 206814 207455 . + . ID=CDS1;locus_tag=Rv0175;product=Probable conserved Mce associated membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 207452 208420 . + . ID=CDS1;locus_tag=Rv0176;product=Probable conserved Mce associated transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 208417 208971 . + . ID=CDS1;locus_tag=Rv0177;product=Probable conserved Mce associated protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:11769 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in membrane associated processes chr1 CDS 208938 209672 . + . ID=CDS1;locus_tag=Rv0178;product=Probable conserved Mce associated membrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 209703 210812 . - . ID=CDS1;locus_tag=Rv0179c;product=Possible lipoprotein LprO;note=FunctionalCategory: cell wall and cell processes chr1 CDS 210892 212250 . - . ID=CDS1;locus_tag=Rv0180c;product=Probable cell surface protein;Experiment=DESCRIPTION:high activity binding protein latex bead internalization [PMID: 20883740]/note:FunctionalCategory: cell wall and cell processes/note:contains Plasmodium Export Element (PEXEL)/Host Cell-Targeting Signal (HCT) motif [PMID: 20883740]/note:contains 13 high-activity binding peptides (HABPs) (possibly involved in invasion of mammalian cells) [PMID: 20883740]/note:co-transcribed with sigG and involved in host cell invasion [PMID: 23871545]/note:possible role in mammalian cell invasion [PMID: 20883740];Inference=protein motif:Scanprosite [PMID: 20883740] chr1 CDS 212277 213011 . - . ID=CDS1;locus_tag=Rv0181c;product=probable quercetin 2,3-dioxygenase;note=FunctionalCategory: conserved hypotheticals, Experimentally determined to be co-transcribed along with SigG[PMID: 23871545];Experiment=DESCRIPTION:Structural analysis and quercetinase enzyme activity assay[PMID: 23871545];EC_number=1.13.11.24,EC_number=1.13.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1j1lA,3g7dA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0032923/note:identified by similarity of predicted tertiary structure to PDB 3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g7dA,Ontology_term=0030224/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0008127/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g7dA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1j1lA,3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,3g7dA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0043565/note:identified by similarity of predicted tertiary structure to PDB 3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g7dA,Ontology_term=0016702/note:identified by similarity of predicted tertiary structure to PDB 3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g7dA,Ontology_term=0003712/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0006366/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1j1lA,3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,3g7dA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0007586/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0008198/note:identified by similarity of predicted tertiary structure to PDB 3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g7dA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g7dA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1j1lA,3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,3g7dA,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 1j1lA,3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,3g7dA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=1901766/note:identified by similarity of predicted tertiary structure to PDB 3g7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g7dA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0030099/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 1j1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j1lA chr1 CDS 213028 214026 . - . ID=CDS1;locus_tag=Rv0182c;product=Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 214088 214927 . + . ID=CDS1;locus_tag=Rv0183;product=Possible lysophospholipase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 214969 215718 . + . ID=CDS1;locus_tag=Rv0184;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 215715 216224 . + . ID=CDS1;locus_tag=Rv0185;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 216359 218344 . + . ID=CDS1;locus_tag=Rv0186;product=Probable beta-glucosidase BglS (gentiobiase) (cellobiase) (beta-D-glucoside glucohydrolase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 218390 218551 . - . ID=CDS1;locus_tag=Rv0186A;product=Metallothionein, MymT;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 218705 219367 . + . ID=CDS1;locus_tag=Rv0187;product=Probable O-methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 219486 219917 . + . ID=CDS1;locus_tag=Rv0188;product=enduring hypoxic response (EHR) antigen;Experiment=DESCRIPTION:antigen screening, ELISA [PMID: 21712953],Experiment=DESCRIPTION:deletion mutagenesis, rolling culture growth in vivo, DNA microarray, beta-galactosidase reporter assay, protein overproduction, band shift assays [PMID: 15882420]/note:FunctionalCategory: cell wall and cell processes/note:shown to up-regulated in Rv3676 mutant strains of Mycobacterium tuberculosis [PMID: 15882420]/note:possible involvement in the early stages of infection [PMID: 21712953] chr1 CDS 219996 221723 . - . ID=CDS1;locus_tag=Rv0189c;product=Probable dihydroxy-acid dehydratase IlvD (dad);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 221871 222161 . + . ID=CDS1;locus_tag=Rv0190;gene=ricR;product=Probable Copper-responsive gene ricR/ probable serine hydrolase/Putative membrane transporter;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:conditional gene overexpression, affinity chromatography, copper sensitivity assay [PMID: 21166899],Experiment=DESCRIPTION:conditional gene overexpression, copper sensitivity assay [PMID: 21166899],Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry [PMID: 26853625],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:identified by similarity of predicted tertiary structure to PDB:3ieeA, 4ry2A1, 4ry2A, 4djiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ieeA, 4ry2A1, 4ry2A, 4djiA;EC_number=3.1.-.- chr1 CDS 222289 223530 . + . ID=CDS1;locus_tag=Rv0191;product=Putative efflux pump/Putative membrane transporter;Experiment=DESCRIPTION:drug susceptibility testing, spoligotyping, RNA extraction, qRT-PCR [PMID: 25690361]/inference:protein motif:MEME [PMID: 12520088]/inference:alignment:ClustalW [PMID: 12520088]/inference:profile:STRING [PMID: 22132058]/inference:profile:Djikstra's algorithm via MATLAB-Boost Graph Library [PMID: 22132058]/note:FunctionalCategory: cell wall and cell processes/note:putative major facilitator superfamily (MFS) transporter resistance protein [PMID: 12520088]/note:probably involved in chloramphenicol resistance [PMID: 12520088]/note:putatively involved in ethambutol and rifampicin resistance [PMID: 22132058]/note:induced by RIF in monoresistant isolates [PMID: 25690361]/note:identified by similarity of predicted tertiary structure to PDB:5c65A, 4gbyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c65A, 4gbyA chr1 CDS 223564 224664 . + . ID=CDS1;locus_tag=Rv0192;product=Probable L,D-transpeptidase;Experiment=DESCRIPTION:Protein purification, L,D-transpeptidase acylation by carbapenems, mass spectrometry analyses of transpeptidation reaction products [PMID: 24041897]/note:FunctionalCategory: conserved hypotheticals,Experiment=DESCRIPTION:protein crystallography, structure determination, mass spectrometry [PMID: 23519418]/note:active in assays of peptidoglycan cross-linking and beta-lactam acylation [PMID: 24041897]/note:inactivated by carbapenems and imipenem [PMID: 24041897];EC_number=2.3.2.-,EC_number=2.3.2.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4hu2A,3turA,3vaeA,4jmnA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3turA,3vaeA,4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3turA,3vaeA,4jmnA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0008360/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0071972/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0009252/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0018104/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA chr1 CDS 223607 223909 . + . ID=CDS1;locus_tag=Rv0192A;product=Conserved secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 224724 226571 . - . ID=CDS1;locus_tag=Rv0193c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 226878 230462 . + . ID=CDS1;locus_tag=Rv0194;product=Probable transmembrane multidrug efflux pump;note=FunctionalCategory: cell wall and cell processes chr1 CDS 230899 231534 . + . ID=CDS1;locus_tag=Rv0195;product=Possible two component transcriptional regulatory protein (probably LuxR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 231647 232231 . + . ID=CDS1;locus_tag=Rv0196;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1sgmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sgmA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1sgmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sgmA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1sgmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sgmA chr1 CDS 232231 234519 . + . ID=CDS1;locus_tag=Rv0197;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 234516 236507 . - . ID=CDS1;locus_tag=Rv0198c;product=Probable zinc metalloprotease Zmp1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 236550 237209 . + . ID=CDS1;locus_tag=Rv0199;gene=omamA;product=Orphaned Mce-associated membrane (Mam) protein A (OmamA);Experiment=DESCRIPTION:mutagenesis, cholesterol metabolism assay, cholesterol uptake assay [PMID: 26712165]/note:FunctionalCategory: cell wall and cell processes/note:involved in (Mce4 transporter-dependent) cholesterol uptake [PMID: 26712165]/note:involved in growth in macrophages [PMID: 21148733] chr1 CDS 237206 237895 . + . ID=CDS1;locus_tag=Rv0200;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, possible mce1-like protein [PMID: 16322769] chr1 CDS 237892 238389 . - . ID=CDS1;locus_tag=Rv0201c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, putatively involved in membrane associated processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:11925 [PMID: 22485162] chr1 CDS 238392 241292 . - . ID=CDS1;locus_tag=Rv0202c;product=Probable conserved transmembrane transport protein MmpL11;note=FunctionalCategory: cell wall and cell processes chr1 CDS 241514 241924 . + . ID=CDS1;locus_tag=Rv0203;product=Heme-binding protein;Experiment=DESCRIPTION:gene expression and purification, site-directed mutagenesis, heme titration, spectroscopy, measuring heme dissociation (apomyoglobin assay) [PMID: 22283334],Experiment=DESCRIPTION:gene expression and purification, ferric heme binding/note:FunctionalCategory: cell wall and cell processes/note:secreted protein involved in heme uptake [PMID: 21383189]/note:Tyr59 is essential for heme binding [PMID: 21383189]/note:transfers heme to MmpL3 and MmpL11 extracellular domains [PMID: 23760277] chr1 CDS 241976 243214 . - . ID=CDS1;locus_tag=Rv0204c;product=Probable conserved transmembrane protein/Putative Transmembrane transporter;note=FunctionalCategory: cell wall and cell processes, possibly part of a complex (mycolic acid (MA) transport system) involved in the transport of trehalose monomycolate [PMID: 22520756], identified by similarity of predicted tertiary structure to PDB 4wisA2;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wisA2 chr1 CDS 243384 244487 . + . ID=CDS1;locus_tag=Rv0205;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, possibly part of a complex (mycolic acid (MA) transport system) involved in the transport of trehalose monomycolate [PMID: 22520756], possible permease [PMID: 16322769] chr1 CDS 244484 247318 . - . ID=CDS1;locus_tag=Rv0206c;product=Possible conserved transmembrane transport protein MmpL3;note=FunctionalCategory: cell wall and cell processes chr1 CDS 247384 248112 . - . ID=CDS1;locus_tag=Rv0207c;product=Conserved hypothetical protein;Experiment=recombinant protein expression via allelic exchange [PMID: 21383189]/inference:profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:05977 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Probably encodes for protein involved in heme uptake[PMID: 21383189]/note:Putatively involved in membrane associated processes [PMID: 22485162] chr1 CDS 248115 248888 . - . ID=CDS1;locus_tag=Rv0208c;product=Putative tRNA (guanine(46)-N(7))-methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=2.1.1.33 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3dxxA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006400/note:identified by similarity of predicted tertiary structure to PDB 3dxxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dxxA,Ontology_term=0008176/note:identified by similarity of predicted tertiary structure to PDB 3dxxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dxxA chr1 CDS 249038 250123 . + . ID=CDS1;locus_tag=Rv0209;product=Putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2r65A,3kdsE,1lv7A,4ww0A,2dhrA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3kdsE,4ww0A,2dhrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kdsE,4ww0A,2dhrA,Ontology_term=0004222/note:identified by similarity of predicted tertiary structure to PDB 2r65A,3kdsE,1lv7A,4ww0A,2dhrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r65A,3kdsE,1lv7A,4ww0A,2dhrA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2r65A,3kdsE,1lv7A,4ww0A,2dhrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r65A,3kdsE,1lv7A,4ww0A,2dhrA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3kdsE,4ww0A,2dhrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kdsE,4ww0A,2dhrA chr1 CDS 250120 251598 . + . ID=CDS1;locus_tag=Rv0210;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 251782 253602 . + . ID=CDS1;locus_tag=Rv0211;product=Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 253669 254640 . - . ID=CDS1;locus_tag=Rv0212c;product=Possible transcriptional regulatory protein NadR (probably AsnC-family);note=FunctionalCategory: regulatory proteins chr1 CDS 254637 255950 . - . ID=CDS1;locus_tag=Rv0213c;product=Possible methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 256064 257677 . + . ID=CDS1;locus_tag=Rv0214;product=Probable fatty-acid-CoA ligase FadD4 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 257783 258856 . - . ID=CDS1;locus_tag=Rv0215c;product=Probable acyl-CoA dehydrogenase FadE3;note=FunctionalCategory: lipid metabolism chr1 CDS 258913 259926 . + . ID=CDS1;locus_tag=Rv0216;product=Double hotdog hydratase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 259923 260831 . - . ID=CDS1;locus_tag=Rv0217c;product=Possible esterase LipW;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 260924 262252 . + . ID=CDS1;locus_tag=Rv0218;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 262254 262802 . + . ID=CDS1;locus_tag=Rv0219;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 262812 264023 . + . ID=CDS1;locus_tag=Rv0220;product=Probable esterase LipC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 264067 265476 . + . ID=CDS1;locus_tag=Rv0221;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 265507 266295 . + . ID=CDS1;locus_tag=Rv0222;product=Probable enoyl-CoA hydratase EchA1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 266301 267764 . - . ID=CDS1;locus_tag=Rv0223c;product=Probable aldehyde dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 267863 268627 . - . ID=CDS1;locus_tag=Rv0224c;product=Possible methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 268663 269817 . + . ID=CDS1;locus_tag=Rv0225;product= putative hexosyltransferase;Inference=similar to DNA sequence:BLAST [PMID: 11532219]/inference:similar to AA sequence:RPS-BLAST [PMID: 11532219]/note:FunctionalCategory: cell wall and cell processes/note:Putative mannosyltransferase [PMID: 11532219]/note:putatively involved in biosynthesis of phosphatidylinositol mannosides, lipomannan and lipoarabinomannan [PMID: 11532219]/note:homologous to pimB [PMID: 11532219]/note:down-regulated during acid-nitrosative multi-stress [PMID: 24184341];EC_number=2.4.1.-;Ontology_term=0033201/note:identified by similarity of predicted tertiary structure to PDB 3copA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3copA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gekA,Ontology_term=0010125/note:identified by similarity of predicted tertiary structure to PDB 3c4qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c4qA,Ontology_term=0008375/note:identified by similarity of predicted tertiary structure to PDB 3c4qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c4qA,Ontology_term=0043750/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2gekA,Ontology_term=0033164/note:identified by similarity of predicted tertiary structure to PDB 3okaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gekA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2bisA,4xsoB,2jjmL,5d00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bisA,4xsoB,2jjmL,5d00A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2jjmL,3copA,3c4qA,5d00A,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2jjmL,3copA,3c4qA,5d00A,2gekA,Ontology_term=0102710/note:identified by similarity of predicted tertiary structure to PDB 3c4qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c4qA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3c4qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c4qA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2gekA,Ontology_term=0009247/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2gekA,Ontology_term=0006974/note:identified by similarity of predicted tertiary structure to PDB 3copA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3copA,Ontology_term=0046488/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2gekA,Ontology_term=0009011/note:identified by similarity of predicted tertiary structure to PDB 3copA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3copA,Ontology_term=0071793/note:identified by similarity of predicted tertiary structure to PDB 2jjmL,5d00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jjmL,5d00A,Ontology_term=0004373/note:identified by similarity of predicted tertiary structure to PDB 2bisA,3copA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bisA,3copA,Ontology_term=0008654/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2gekA,Ontology_term=0005978/note:identified by similarity of predicted tertiary structure to PDB 3copA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3copA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3copA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3copA,Ontology_term=0004377/note:identified by similarity of predicted tertiary structure to PDB 2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gekA,Ontology_term=0097502/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2gekA,Ontology_term=0016757/note:identified by similarity of predicted tertiary structure to PDB 3okaA,2jjmL,3copA,3c4qA,5d00A,2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3okaA,2jjmL,3copA,3c4qA,5d00A,2gekA,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 2gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gekA chr1 CDS 269834 271564 . - . ID=CDS1;locus_tag=Rv0226c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 271574 272839 . - . ID=CDS1;locus_tag=Rv0227c;product=Probable cell-surface protein;Experiment=DESCRIPTION:Immunodetection assays, peptide interaction with target cells, Mycobacterial invasion and cytotoxicity assays (using M. tuberculosis), CD spectroscopy [PMID: 23000473]/note:FunctionalCategory: cell wall and cell processes/note:contains high activity binding peptides (HABPs) which inhibit cell invasion (in vitro) [PMID: 23000473]/note:putatively involved in mycolic acid biosynthesis (based on evidence from functional linkage predictions using phylogenetic profiling) [PMID: 21573108]/note:possible drug design target [PMID: 21573108] chr1 CDS 273055 274278 . + . ID=CDS1;locus_tag=Rv0228;product=Probable integral membrane acyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 274306 274986 . - . ID=CDS1;locus_tag=Rv0229c;product=Possible conserved membrane protein with PIN domain/putative ester hydrolase;note=FunctionalCategory: cell wall and cell processes;EC_number=3.1.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0090501/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0045926/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0040008/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0004540/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0090305/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A chr1 CDS 274983 275963 . - . ID=CDS1;locus_tag=Rv0230c;product=Probable phosphotriesterase Php (parathion hydrolase) (PTE) (aryldialkylphosphatase) (paraoxonase) (a-esterase) (aryltriphosphatase) (paraoxon hydrolase);note=FunctionalCategory: lipid metabolism chr1 CDS 276058 277764 . + . ID=CDS1;locus_tag=Rv0231;product=Probable acyl-CoA dehydrogenase FadE4;note=FunctionalCategory: lipid metabolism chr1 CDS 277899 278588 . + . ID=CDS1;locus_tag=Rv0232;product=Probable transcriptional regulatory protein (probably TetR/AcrR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 278585 279529 . + . ID=CDS1;locus_tag=Rv0233;product=Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain);note=FunctionalCategory: information pathways chr1 CDS 279605 281140 . - . ID=CDS1;locus_tag=Rv0234c;product=Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 281166 282614 . - . ID=CDS1;locus_tag=Rv0235c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, down-regulated when DnaJ1 is overexpressed [PMID: 15207487] chr1 CDS 282649 286851 . - . ID=CDS1;locus_tag=Rv0236c;product=Possible arabinofuranosyltransferase AftD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 286898 287071 . - . ID=CDS1;locus_tag=Rv0236A;product=Small secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 287186 288352 . + . ID=CDS1;locus_tag=Rv0237;product=Probable conserved lipoprotein LpqI;note=FunctionalCategory: cell wall and cell processes chr1 CDS 288428 289042 . + . ID=CDS1;locus_tag=Rv0238;product=Possible transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 289104 289337 . + . ID=CDS1;locus_tag=Rv0239;product=Possible antitoxin VapB24;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 289345 289782 . + . ID=CDS1;locus_tag=Rv0240;product=Possible toxin VapC24. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 289812 290654 . - . ID=CDS1;locus_tag=Rv0241c;product=Probable 3-hydroxyacyl-thioester dehydratase HtdX;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 290665 292029 . - . ID=CDS1;locus_tag=Rv0242c;product=Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase);note=FunctionalCategory: lipid metabolism chr1 CDS 292171 293493 . + . ID=CDS1;locus_tag=Rv0243;product=Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase);note=FunctionalCategory: lipid metabolism chr1 CDS 293798 295633 . - . ID=CDS1;locus_tag=Rv0244c;product=Probable acyl-CoA dehydrogenase FadE5;note=FunctionalCategory: lipid metabolism chr1 CDS 296005 296493 . + . ID=CDS1;locus_tag=Rv0245;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 296809 298119 . + . ID=CDS1;locus_tag=Rv0246;product=Immunogenic antigen/putative membrane transport protein;Experiment=DESCRIPTION:IFN-γ measurement using ELISA [PMID: 23015647]/note:FunctionalCategory: cell wall and cell processes/note:homologous to M. marinum mimA (macrophage infection mutants) gene [PMID: 16451826]/note:elicits IFN-gamma response in host [PMID: 23015647]/note:up-regulated during hypoxia [PMID: 26001906]/note:identified by similarity of predicted tertiary structure to PDB 4j05A, 4gbyA, 5c65A, 4ybqA, 4pypA, 4zowA, 4iu8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4j05A, 4gbyA, 5c65A, 4ybqA, 4pypA, 4zowA, 4iu8A chr1 CDS 298116 298862 . - . ID=CDS1;locus_tag=Rv0247c;product=Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 298863 300803 . - . ID=CDS1;locus_tag=Rv0248c;product=Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 300834 301655 . - . ID=CDS1;locus_tag=Rv0249c;product=Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 301735 302028 . - . ID=CDS1;locus_tag=Rv0250c;product=Conserved protein;Experiment=DESCRIPTION:Chromatin Immunoprecipitation, Electrophoretic mobility shift assay (EMSA), fusion protein construction [PMID: 25940627]/note:FunctionalCategory: conserved hypotheticals/note:Putatively contains CRP binding sites and contributes to the regulation of succinate dehydrogenase genes[PMID: 25940627],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 302173 302652 . - . ID=CDS1;locus_tag=Rv0251c;product=Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 302866 305427 . + . ID=CDS1;locus_tag=Rv0252;product=Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 305453 305809 . + . ID=CDS1;locus_tag=Rv0253;product=Probable nitrite reductase [NAD(P)H] small subunit NirD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 305825 306349 . - . ID=CDS1;locus_tag=Rv0254c;product=Probable bifunctional cobalamin biosynthesis protein CobU: cobinamide kinase + cobinamide phosphate guanylyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 306374 307858 . - . ID=CDS1;locus_tag=Rv0255c;product=Probable cobyric acid synthase CobQ1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 307877 309547 . - . ID=CDS1;locus_tag=Rv0256c;gene=PPE2;product=bifunctional B cell Antigen and probable INOS promoter binding protein;Experiment=DESCRIPTION: protein expression and purification, Enzyme immunoassay. [PMID: 23827809],Experiment=DESCRIPTION: recombinant protein expression in E. Coli, western blot, site-directed mutagenesis, semi-quantitative RT-PCR, macrophage infection, in vivo mouse infection studies, EMSA, pull down assay, reverse transcription qPCR for inos mRNA quantification [PMID: 28071726]/note:FunctionalCategory: PE/PPE/note:inhibits nitric oxide (NO) production in macrophages [PMID: 28071726]/note:can be used as a highly sensitive TB diagnostic test in patients via inducing a strong IgG response [PMID: 23827809]/note:promotes Mtb survival in infected macrophages [PMID: 28071726] chr1 CDS 309699 310073 . + . ID=CDS1;locus_tag=Rv0257;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 310294 310749 . - . ID=CDS1;locus_tag=Rv0258c;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2np3B2,2np3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np3B2,2np3B,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2np3B2,2np3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np3B2,2np3B,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2np3B2,2np3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np3B2,2np3B,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 2np3B2,2np3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np3B2,2np3B,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2np3B2,2np3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np3B2,2np3B,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2np3B2,2np3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np3B2,2np3B chr1 CDS 310774 311517 . - . ID=CDS1;locus_tag=Rv0259c;product=Putative lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.99.1.- (Putative);Ontology_term=0016852/note:identified by similarity of predicted tertiary structure to PDB 2jh3A,4ccsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jh3A,4ccsA,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 2jh3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jh3A,Ontology_term=0009236/note:identified by similarity of predicted tertiary structure to PDB 2jh3A,4ccsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jh3A,4ccsA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 2jh3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jh3A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2jh3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jh3A,Ontology_term=0005840/note:identified by similarity of predicted tertiary structure to PDB 2jh3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jh3A chr1 CDS 311514 312659 . - . ID=CDS1;locus_tag=Rv0260c;product=Possible transcriptional regulatory protein/Putative hydrolyase;note=FunctionalCategory: regulatory proteins, up-regulated in starvation conditions [PMID: 24268774], up-regulated in nitrogen restriction [PMID: 26077160], possible two-component response regulator[PMID: 22737072];EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1wd7B/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0033014/note:identified by similarity of predicted tertiary structure to PDB 1wd7B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wd7B,Ontology_term=0004852/note:identified by similarity of predicted tertiary structure to PDB 1wd7B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wd7B chr1 CDS 312759 314168 . - . ID=CDS1;locus_tag=Rv0261c;product=Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator);note=FunctionalCategory: cell wall and cell processes chr1 CDS 314309 314854 . - . ID=CDS1;locus_tag=Rv0262c;product=Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 314864 315766 . - . ID=CDS1;locus_tag=Rv0263c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Has homology to prokaryotic 5-oxoprolinase subunit C but M. tuberculosis lacks pxpA homolog, so unlikely 5-oxoprolinase activity. Potential allophonate hydrolase function [PMID: 28830929];Inference=ab initio prediction:I-TASSER:5.1;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3mmlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mmlA chr1 CDS 315783 316415 . - . ID=CDS1;locus_tag=Rv0264c;product=Conserved hypothetical protein;Experiment=DESCRIPTION:RT-PCR [PMID: 24058507]/note:FunctionalCategory: conserved hypotheticals/note:Potential marker for Mycobacterium tuberculosis detection [PMID: 24058507]/note:Has homology to prokaryotic 5-oxoprolinase subunit B, but M. tuberculosis lacks pxpA homolog, so unlikely 5-oxoprolinase activity. Potential allophonate hydrolase function [PMID: 28830929];Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3va7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3va7A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3va7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3va7A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3va7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3va7A chr1 CDS 316511 317503 . - . ID=CDS1;locus_tag=Rv0265c;product=Probable periplasmic iron-transport lipoprotein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 317525 321154 . - . ID=CDS1;locus_tag=Rv0266c;product=Probable 5-oxoprolinase OplA (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 321331 322722 . + . ID=CDS1;locus_tag=Rv0267;product=Probable integral membrane nitrite extrusion protein NarU (nitrite facilitator);note=FunctionalCategory: cell wall and cell processes chr1 CDS 322764 323273 . - . ID=CDS1;locus_tag=Rv0268c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 323338 324531 . - . ID=CDS1;locus_tag=Rv0269c;gene=polD2;product=putative DNA polymerase PolD2;Experiment=DESCRIPTION:purified and cloned from M.smegmatis, polymerase assay, non-homologous end joining assay [PMID: 23198659]/note:FunctionalCategory: conserved hypotheticals/note:Predicted homology with a putative RNA polymerase in M. smegmatis[PMID: 23198659];EC_number=2.7.7.7,EC_number=2.7.7.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2iryA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 324567 326249 . + . ID=CDS1;locus_tag=Rv0270;product=Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 326266 328461 . - . ID=CDS1;locus_tag=Rv0271c;product=Probable acyl-CoA dehydrogenase FadE6;note=FunctionalCategory: lipid metabolism chr1 CDS 328575 329708 . - . ID=CDS1;locus_tag=Rv0272c;product=probable serine hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.- chr1 CDS 329705 330325 . - . ID=CDS1;locus_tag=Rv0273c;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins, regulated by sigma H [PMID: 19376862];Ontology_term=0019217/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 4w97A,1t33A,1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,1t33A,1u9nA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,1t33A,1u9nA,3himB,3pasA,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,1t33A,1u9nA,3himB,3pasA,4w97A,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,1t33A,1u9nA,3himB,3pasA,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,1t33A,1u9nA,3himB,3pasA,4w97A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,1t33A,1u9nA,3himB,3pasA,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,1t33A,1u9nA,3himB,3pasA,4w97A,Ontology_term=0045892/note:identified by similarity of predicted tertiary structure to PDB 1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,Ontology_term=0010468/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A chr1 CDS 330422 331003 . + . ID=CDS1;locus_tag=Rv0274;product=Conserved protein/putative carbon-sulfur lyase;Experiment=Sothern blot, Toxin and antibiotic sensitivity assays, liquid growth assays [PMID: 12670676]/inference:similar to AA sequence: BLAST [PMID: 12670676]/note:FunctionalCategory: conserved hypotheticals/note:Putative thiol specific detoxification protein [PMID: 12670676];EC_number=4.4.1.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2p7pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p7pA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3l7tA,2p7pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l7tA,2p7pA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 2p7pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p7pA,Ontology_term=0004462/note:identified by similarity of predicted tertiary structure to PDB 3l7tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l7tA chr1 CDS 330933 331658 . - . ID=CDS1;locus_tag=Rv0275c;product=Possible transcriptional regulatory protein (possibly TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 331748 332668 . + . ID=CDS1;locus_tag=Rv0276;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 332708 333136 . - . ID=CDS1;locus_tag=Rv0277c;product=Possible toxin VapC25. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 333160 333417 . - . ID=CDS1;locus_tag=Rv0277A;product=Possible antitoxin VapB25;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 333437 336310 . - . ID=CDS1;locus_tag=Rv0278c;gene=PE_PGRS3;product=PE-PGRS family protein PE_PGRS3;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 336560 339073 . - . ID=CDS1;locus_tag=Rv0279c;gene=PE_PGRS4;product=PE-PGRS family protein PE_PGRS4;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 339364 340974 . + . ID=CDS1;locus_tag=Rv0280;gene=PPE3;product=PPE family protein PPE3;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642]/note:Down regulated in otsB2 mutant strain (trehalose-6-phosphate phosphatase silenced strain) [PMID: 27936238] chr1 CDS 340998 341906 . + . ID=CDS1;locus_tag=Rv0281;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 342163 344025 . + . ID=CDS1;locus_tag=Rv0282;product=ESX conserved component EccA3. ESX-3 type VII secretion system protein.;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 344022 345638 . + . ID=CDS1;locus_tag=Rv0283;product=ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 345635 349627 . + . ID=CDS1;locus_tag=Rv0284;product=ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 349624 349932 . + . ID=CDS1;locus_tag=Rv0285;gene=PE5;product=PE family protein PE5;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry [PMID: 21920479],Experiment=EXISTENCE:2-dimensional gel electrophoresis, liquid chromatography mass spectrometry [PMID: 17443846]/note:FunctionalCategory: PE/PPE/note:putatively co-expressed with Rv1386 (PE15), which are both involved in the shifting of the Th1 and Th2 type balance to favor Mtb infection. [PMID: 23284742]/note:triggers activation of the MAP kinase pathway, which results in the mediation of IL-10 production [PMID: 23284742]/note:located in the cell membrane [PMID: 21920479]/note:probably secreted and found expressed in the culture filtrate [PMID: 17443846, 21920479],Experiment=ally verified N-terminal signal peptide cleavage site [PMID: 17443846, 21920479] chr1 CDS 349935 351476 . + . ID=CDS1;locus_tag=Rv0286;gene=PPE4;product=PPE family protein PPE4;Experiment=RT-PCR [PMID: 27245412]/note:FunctionalCategory: PE/PPE/note:expression repressed in the presence of Iron when Zinc is absent [PMID: 27245412] chr1 CDS 351525 351818 . + . ID=CDS1;locus_tag=Rv0287;product=ESAT-6 like protein EsxG (conserved protein TB9.8);note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 351848 352138 . + . ID=CDS1;locus_tag=Rv0288;gene=esxH;product=Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4) | Type VII secreted effector human hepatocyte growth factor-regulated tyrosine kinase substrate binding protein /Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4)/Type VII secreted effector human hepatocyte growth factor-regulated tyrosine kinase substrate binding protein/Putative protein-serine/threonine kinase;note=FunctionalCategory: cell wall and cell processes, RT-PCR [PMID: 27245412], Rv0288 ligands have a profound impact on T-cell recognition. [PMID: 23555576], Important for proteasomal cleavage and epitope priming. [PMID: 24677089], Probable CE8+ T-cell antigen. [PMID: 24677089], Diminished secretion in response to Zinc and Iron [PMID: 27245412], Directly impairs the adaptive immune response by inhibiting host endosomal sorting complex required for transport machinery, which is required for optimal antigen processing [PMID: 27918526], Forms a heterodimer with EsxG and binds to a component of the host endosomal complex required for transport machinery [PMID: 24204276], arrests phagosome maturation [PMID: 24204276];EC_number=2.7.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1wa8B/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0052083/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0052027/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0020002/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0044315/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0044228/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0046812/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0033644/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0044764/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0030430/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0044165/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1wa8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wa8B chr1 CDS 352149 353036 . + . ID=CDS1;locus_tag=Rv0289;product=ESX-3 secretion-associated protein EspG3;note=FunctionalCategory: cell wall and cell processes chr1 CDS 353083 354501 . + . ID=CDS1;locus_tag=Rv0290;product=ESX conserved component EccD3. ESX-3 type VII secretion system protein. Probable transmembrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 354498 355883 . + . ID=CDS1;locus_tag=Rv0291;product=Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 355880 356875 . + . ID=CDS1;locus_tag=Rv0292;product=ESX conserved component EccE3. ESX-3 type VII secretion system protein. Probable transmembrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 356862 358064 . - . ID=CDS1;locus_tag=Rv0293c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 358171 358956 . + . ID=CDS1;locus_tag=Rv0294;product=Probable trans-aconitate methyltransferase Tam;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 358945 359748 . - . ID=CDS1;locus_tag=Rv0295c;gene=stf0;product=Trehalose 2-sulfotransferase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Protein purification and expression, Gene knockout, sulfotransferase assay, X-ray crystallography [PMID: 15258569];EC_number=2.8.2.37 chr1 CDS 359758 361155 . - . ID=CDS1;locus_tag=Rv0296c;product=Probable sulfatase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 361334 363109 . + . ID=CDS1;locus_tag=Rv0297;gene=PE_PGRS5;product=PE-PGRS family protein PE_PGRS5;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 363252 363479 . + . ID=CDS1;locus_tag=Rv0298;product=Putative Antitoxin;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Expression of TA-system in M. smegmatis[PMID: 20011113] chr1 CDS 363476 363778 . + . ID=CDS1;locus_tag=Rv0299;product=;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Expression of TA-system in M. smegmatis[PMID: 20011113] chr1 CDS 363826 364047 . + . ID=CDS1;locus_tag=Rv0300;product=Possible antitoxin VapB2;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 364044 364469 . + . ID=CDS1;locus_tag=Rv0301;product=Possible toxin VapC2;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 364605 365237 . + . ID=CDS1;locus_tag=Rv0302;product=Probable transcriptional regulatory protein (probably TetR/AcrR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 365234 366142 . + . ID=CDS1;locus_tag=Rv0303;product=Probable dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 366150 372764 . - . ID=CDS1;locus_tag=Rv0304c;gene=PPE5;product=PPE family protein PPE5;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection. [PMID: 21085642] chr1 CDS 372820 375711 . - . ID=CDS1;locus_tag=Rv0305c;gene=PPE6;product=PPE family protein PPE6;note=FunctionalCategory: PE/PPE chr1 CDS 375914 376585 . + . ID=CDS1;locus_tag=Rv0306;product=Putative oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 376573 377055 . - . ID=CDS1;locus_tag=Rv0307c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 377113 377829 . + . ID=CDS1;locus_tag=Rv0308;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 377931 378587 . + . ID=CDS1;locus_tag=Rv0309;product=Adhesin/Putative L,D-transpeptidase;Experiment=DESCRIPTION:protein expression and purification, circular dichroism (CD), western blotting, modified ELISA [PMID: 23922800]/inference:similar to AA sequence: identifying probable adhesin-like proteins via a neural network algorithm (SPAAN) [PMID: 23922800]/inference:similar to AA sequence: identifying probable adhesin-like proteins via sub-cellular localization prediction algorithms (LOCTree, PSORTb, SubLoc) [PMID: 23922800]/inference:protein motif:CDD, Pfam, InterProScan:YkuD super family domain [PMID: 23922800]/inference:protein motif:TMHMM 2.0, SignalP 3.0 [PMID: 23922800]/note:FunctionalCategory: cell wall and cell processes/note:gene may undergo antigenic variation in response to host immune pressure and may be involved in diversifying selection to evade host immunity [PMID: 23889607]/note:binds to fibronectin and laminin [PMID: 23922800],Experiment=ally but its enzymatic activity (as a transpeptidase) is yet to be verified [PMID: 23922800]/note:exported protein (part of extracellular vesicles) [PMID: 26201501];EC_number=2.3.2.- chr1 CDS 378657 379148 . - . ID=CDS1;locus_tag=Rv0310c;product=Conserved protein/Putative lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3a76A/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.2.1.106 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4l8oA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 3a76A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a76A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3a76A,4l8oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a76A,4l8oA,Ontology_term=0009636/note:identified by similarity of predicted tertiary structure to PDB 3a76A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a76A,Ontology_term=0033988/note:identified by similarity of predicted tertiary structure to PDB 4l8oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l8oA chr1 CDS 379172 380401 . + . ID=CDS1;locus_tag=Rv0311;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 380556 382418 . + . ID=CDS1;locus_tag=Rv0312;product=putative ATPase/chaperone;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.-;Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0006457/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0016887/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0043241/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0051085/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0051087/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0051082/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0006260/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0070389/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0006461/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=1903506/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0043531/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0016989/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0044183/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA,Ontology_term=0034620/note:identified by similarity of predicted tertiary structure to PDB 2khoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2khoA chr1 CDS 382490 382876 . + . ID=CDS1;locus_tag=Rv0313;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 382879 383514 . - . ID=CDS1;locus_tag=Rv0314c;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 383602 384486 . + . ID=CDS1;locus_tag=Rv0315;product=Possible beta-1,3-glucanase precursor;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 384535 385149 . + . ID=CDS1;locus_tag=Rv0316;product=Possible muconolactone isomerase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 385173 385943 . - . ID=CDS1;locus_tag=Rv0317c;product=Possible glycerophosphoryl diester phosphodiesterase GlpQ2 (glycerophosphodiester phosphodiesterase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 386305 387099 . - . ID=CDS1;locus_tag=Rv0318c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes, possible zinc/iron transporter (low sequence homology to E.coli ZupT) [PMID: 18752625] chr1 CDS 387148 387816 . + . ID=CDS1;locus_tag=Rv0319;product=Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 387888 388550 . + . ID=CDS1;locus_tag=Rv0320;product=Possible conserved exported protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 388582 389154 . + . ID=CDS1;locus_tag=Rv0321;product=Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 389260 390591 . + . ID=CDS1;locus_tag=Rv0322;product=Probable UDP-glucose 6-dehydrogenase UdgA (UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 390580 391251 . - . ID=CDS1;locus_tag=Rv0323c;product=Putative hydro-lyase/Putative linear amide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1q7tA/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5cgzA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1q7tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q7tA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 5cgzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5cgzA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1q7tA,5cgzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q7tA,5cgzA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1q7tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q7tA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 5cgzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5cgzA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1q7tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q7tA,Ontology_term=0019396/note:identified by similarity of predicted tertiary structure to PDB 5cgzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5cgzA,Ontology_term=0016811/note:identified by similarity of predicted tertiary structure to PDB 1q7tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q7tA,Ontology_term=0047584/note:identified by similarity of predicted tertiary structure to PDB 5cgzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5cgzA,Ontology_term=0035595/note:identified by similarity of predicted tertiary structure to PDB 1q7tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q7tA,Ontology_term=0019439/note:identified by similarity of predicted tertiary structure to PDB 5cgzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5cgzA,Ontology_term=0010125/note:identified by similarity of predicted tertiary structure to PDB 1q7tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q7tA chr1 CDS 391352 392032 . + . ID=CDS1;locus_tag=Rv0324;product=Possible transcriptional regulatory protein (possibly ArsR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 392039 392263 . + . ID=CDS1;locus_tag=Rv0325;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 392273 392728 . + . ID=CDS1;locus_tag=Rv0326;product=Putative methyltransferase;note=FunctionalCategory: unknown;EC_number=2.1.1.- (Putative);Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2p8jA,3busA,4pneA,5gm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p8jA,3busA,4pneA,5gm1A,Ontology_term=0102082/note:identified by similarity of predicted tertiary structure to PDB 3busA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3busA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 1ve3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ve3B,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2p8jA,3busA,4pneA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p8jA,3busA,4pneA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2p8jA,3busA,4pneA,5gm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p8jA,3busA,4pneA,5gm1A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2p8jA,3busA,4pneA,5gm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p8jA,3busA,4pneA,5gm1A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1ve3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ve3B,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 1ve3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ve3B chr1 CDS 392696 394045 . - . ID=CDS1;locus_tag=Rv0327c;product=Possible cytochrome P450 135A1 Cyp135A1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 394111 394713 . + . ID=CDS1;locus_tag=Rv0328;product=Possible transcriptional regulatory protein (possibly TetR/AcrR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 394694 395320 . - . ID=CDS1;locus_tag=Rv0329c;product=Putative methyltransferase;Inference=ab initio prediction: GLobPlot, ProtParam, ExPASy [PMID: 26983646]/inference:similar to AA sequence: BLASTP [PMID: 26983646]/inference:alignment: Multiple Sequence Alignment using MUSCLE [PMID: 26983646]/note:FunctionalCategory: conserved hypotheticals/note:Putative SAM-dependent methyltransferase[PMID: 26983646];EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4qdjA,4iv0A,2ex4A,4kvzA,1tw2B,3gwzA,4obwA,3vc1A,1wznA,4kwcA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 1tw2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tw2B,Ontology_term=0035572/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0008276/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0018013/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0035573/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0008169/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 4qdjA,4iv0A,2ex4A,1tw2B,3gwzA,4obwA,3vc1A,4kwcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qdjA,4iv0A,2ex4A,1tw2B,3gwzA,4obwA,3vc1A,4kwcA,Ontology_term=0015979/note:identified by similarity of predicted tertiary structure to PDB 4qdjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qdjA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2ex4A,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,3vc1A,Ontology_term=0042214/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0015995/note:identified by similarity of predicted tertiary structure to PDB 4qdjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qdjA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=1901663/note:identified by similarity of predicted tertiary structure to PDB 3gwzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gwzA,Ontology_term=0036068/note:identified by similarity of predicted tertiary structure to PDB 4qdjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qdjA,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4qdjA,4iv0A,2ex4A,1tw2B,3gwzA,3vc1A,4kwcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qdjA,4iv0A,2ex4A,1tw2B,3gwzA,3vc1A,4kwcA,Ontology_term=0016571/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0018011/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0018012/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 4qdjA,4iv0A,2ex4A,1tw2B,3gwzA,3vc1A,4kwcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qdjA,4iv0A,2ex4A,1tw2B,3gwzA,3vc1A,4kwcA,Ontology_term=0018016/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0071885/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0006480/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0046406/note:identified by similarity of predicted tertiary structure to PDB 4qdjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qdjA,Ontology_term=0008757/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0042054/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0007051/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0008171/note:identified by similarity of predicted tertiary structure to PDB 1tw2B,3gwzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tw2B,3gwzA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0007059/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4iv0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 4iv0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 4iv0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,Ontology_term=1901771/note:identified by similarity of predicted tertiary structure to PDB 1tw2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tw2B,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2ex4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex4A chr1 CDS 395347 396087 . - . ID=CDS1;locus_tag=Rv0330c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 396201 397367 . + . ID=CDS1;locus_tag=Rv0331;product=Possible dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 397442 398227 . + . ID=CDS1;locus_tag=Rv0332;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 398254 398628 . + . ID=CDS1;locus_tag=Rv0333;product=Unknown protein/Putative ether hydrolase/Putative intramolecular lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=5.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3rgaA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.3.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bngC,1nu3B,5aifA,5aihA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 3rgaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rgaA,Ontology_term=0004301/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0018744/note:identified by similarity of predicted tertiary structure to PDB 1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nu3B,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bngC,1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,1nu3B,Ontology_term=0033963/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 3rgaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rgaA,Ontology_term=0097176/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC chr1 CDS 398658 399524 . + . ID=CDS1;locus_tag=Rv0334;product=Alpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) (dTDP-glucose pyrophosphorylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 399535 400050 . - . ID=CDS1;locus_tag=Rv0335c;gene=PE6;product=PE family protein PE6;note=FunctionalCategory: PE/PPE chr1 CDS 400192 401703 . + . ID=CDS1;locus_tag=Rv0336;product=Conserved 13E12 repeat family protein;Experiment=DESCRIPTION:ChIP-seq [PMID: 22528497]/note:FunctionalCategory: insertion seqs and phages/note:Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 22528497] chr1 CDS 401873 403162 . - . ID=CDS1;locus_tag=Rv0337c;product=Probable aspartate aminotransferase AspC (transaminase A) (ASPAT);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 403193 405841 . - . ID=CDS1;locus_tag=Rv0338c;product=Probable iron-sulfur-binding reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 405950 408448 . - . ID=CDS1;locus_tag=Rv0339c;product=Possible transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins, possibly involved in regulation of latency/dormancy [PMID: 23146828] chr1 CDS 408634 409173 . + . ID=CDS1;locus_tag=Rv0340;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 409362 410801 . + . ID=CDS1;locus_tag=Rv0341;gene=iniB;product=Isoniazid inducible gene protein IniB;note=FunctionalCategory: cell wall and cell processes, up-regulated upon pknF deletion [PMID: 23915284] chr1 CDS 410838 412760 . + . ID=CDS1;locus_tag=Rv0342;gene=iniA;product=Isoniazid inducible gene protein IniA/putative GTPase;note=FunctionalCategory: cell wall and cell processes;EC_number=3.6.5.- (Putative)/note:potential phosphohydrolase/note:identified by similarity of predicted tertiary structure to PDB:2j69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j69A chr1 CDS 412757 414238 . + . ID=CDS1;locus_tag=Rv0343;gene=iniC;product=Isoniazid inducible gene protein IniC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 414381 414941 . - . ID=CDS1;locus_tag=Rv0344c;product=Probable lipoprotein LpqJ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 415050 415460 . + . ID=CDS1;locus_tag=Rv0345;product=Putative transferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.-.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0035635/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0019134/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0003977/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0009252/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0009103/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0000902/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0044650/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0009245/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0008360/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0006048/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0070569/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA chr1 CDS 415502 416965 . - . ID=CDS1;locus_tag=Rv0346c;product=Possible L-asparagine permease AnsP2 (L-asparagine transport protein);note=FunctionalCategory: cell wall and cell processes chr1 CDS 417304 418290 . + . ID=CDS1;locus_tag=Rv0347;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes, mutagenesis studies suggest essentiality of Rv0347 for Mtb growth [PMID: 14569030] [PMID: 21980284], belongs to the mosR operon [PMID: 19648248], up-regulated during oxygen depletion [PMID: 26001906] chr1 CDS 418293 418946 . + . ID=CDS1;locus_tag=Rv0348;product=possible transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins, Up-regulated during hypoxia in vitro and in vivo [PMID: 26001906];Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 418949 419608 . + . ID=CDS1;locus_tag=Rv0349;product=Hypothetical protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:81154 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in DNA associated processes chr1 CDS 419835 421712 . + . ID=CDS1;locus_tag=Rv0350;product=Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 421709 422416 . + . ID=CDS1;locus_tag=Rv0351;product=Probable GrpE protein (HSP-70 cofactor);note=FunctionalCategory: virulence, detoxification, adaptation;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 422452 423639 . + . ID=CDS1;locus_tag=Rv0352;product=Probable chaperone protein DnaJ1;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 423639 424019 . + . ID=CDS1;locus_tag=Rv0353;product=Probable heat shock protein transcriptional repressor HspR (MerR family);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 424269 424694 . - . ID=CDS1;locus_tag=Rv0354c;gene=PPE7;product=PPE family protein PPE7;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 424777 434679 . - . ID=CDS1;locus_tag=Rv0355c;gene=PPE8;product=PPE family protein PPE8;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 434830 435474 . - . ID=CDS1;locus_tag=Rv0356c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 435471 436769 . - . ID=CDS1;locus_tag=Rv0357c;product=Probable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 436860 437507 . + . ID=CDS1;locus_tag=Rv0358;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 437518 438297 . + . ID=CDS1;locus_tag=Rv0359;product=Probable conserved integral membrane protein/Putative metalloendopeptidase;note=FunctionalCategory: cell wall and cell processes;EC_number=3.4.24.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3b4rA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004222/note:identified by similarity of predicted tertiary structure to PDB 3b4rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b4rA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3b4rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b4rA chr1 CDS 438302 438739 . - . ID=CDS1;locus_tag=Rv0360c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 438822 439649 . + . ID=CDS1;locus_tag=Rv0361;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes, putatively secreted to the mycobacterial surface or the extracellular milieu [PMID: 20585611];Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 439871 441253 . + . ID=CDS1;locus_tag=Rv0362;product=Possible Mg2+ transport transmembrane protein MgtE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 441265 442299 . - . ID=CDS1;locus_tag=Rv0363c;product=Probable fructose-bisphosphate aldolase Fba;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 442395 443078 . + . ID=CDS1;locus_tag=Rv0364;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 443067 444197 . - . ID=CDS1;locus_tag=Rv0365c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 444222 444815 . - . ID=CDS1;locus_tag=Rv0366c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 444844 445233 . - . ID=CDS1;locus_tag=Rv0367c;product=Hypothetical protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:145257 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in signal transduction [PMID: 22485162] chr1 CDS 445314 446525 . - . ID=CDS1;locus_tag=Rv0368c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 446531 447046 . - . ID=CDS1;locus_tag=Rv0369c;product=Possible membrane oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 447147 448043 . - . ID=CDS1;locus_tag=Rv0370c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 448040 448633 . - . ID=CDS1;locus_tag=Rv0371c;product=Putative nucleotidyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.7.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4kt7A,3fwwA,2y6pA,1g3lD,1yp3C,3hl3A,2xwlA,4cvhA,1vpaA,5i1fA,1wvcA,1i52A,1hm8A,2vsiB,2e3dC,2yqjA,2pa4B,3d8vA,5l6sA,5ddtA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0035635/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0008690/note:identified by similarity of predicted tertiary structure to PDB 2y6pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2y6pA,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 2e3dC,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2e3dC,5l6sA,Ontology_term=0019134/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,Ontology_term=0033499/note:identified by similarity of predicted tertiary structure to PDB 2e3dC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2e3dC,Ontology_term=0019288/note:identified by similarity of predicted tertiary structure to PDB 4kt7A,2xwlA,1vpaA,1i52A,5ddtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kt7A,2xwlA,1vpaA,1i52A,5ddtA,Ontology_term=0003977/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A,2yqjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,2yqjA,Ontology_term=0050518/note:identified by similarity of predicted tertiary structure to PDB 4kt7A,2xwlA,1vpaA,1i52A,5ddtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kt7A,2xwlA,1vpaA,1i52A,5ddtA,Ontology_term=0009252/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,Ontology_term=0007411/note:identified by similarity of predicted tertiary structure to PDB 4cvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cvhA,Ontology_term=0045226/note:identified by similarity of predicted tertiary structure to PDB 1g3lD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1g3lD,Ontology_term=0009103/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,2y6pA,1wvcA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,2y6pA,1wvcA,1hm8A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,2y6pA,4cvhA,1hm8A,2yqjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,2y6pA,4cvhA,1hm8A,2yqjA,Ontology_term=0035269/note:identified by similarity of predicted tertiary structure to PDB 4cvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cvhA,Ontology_term=0000902/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,Ontology_term=0033468/note:identified by similarity of predicted tertiary structure to PDB 2y6pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2y6pA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1i52A,1hm8A,2e3dC,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1i52A,1hm8A,2e3dC,5l6sA,Ontology_term=0006011/note:identified by similarity of predicted tertiary structure to PDB 5i1fA,2e3dC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5i1fA,2e3dC,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1g3lD,2xwlA,1wvcA,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1g3lD,2xwlA,1wvcA,5l6sA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,4kt7A,2y6pA,1g3lD,3hl3A,2xwlA,4cvhA,1vpaA,5i1fA,1wvcA,1i52A,1hm8A,2e3dC,2yqjA,5l6sA,5ddtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,4kt7A,2y6pA,1g3lD,3hl3A,2xwlA,4cvhA,1vpaA,5i1fA,1wvcA,1i52A,1hm8A,2e3dC,2yqjA,5l6sA,5ddtA,Ontology_term=0044650/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1g3lD,1wvcA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1g3lD,1wvcA,1hm8A,Ontology_term=0003983/note:identified by similarity of predicted tertiary structure to PDB 5i1fA,2e3dC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5i1fA,2e3dC,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1i52A,2e3dC,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1i52A,2e3dC,5l6sA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 4cvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cvhA,Ontology_term=0016208/note:identified by similarity of predicted tertiary structure to PDB 5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5l6sA,Ontology_term=0009243/note:identified by similarity of predicted tertiary structure to PDB 3hl3A,1wvcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hl3A,1wvcA,Ontology_term=0009242/note:identified by similarity of predicted tertiary structure to PDB 2e3dC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2e3dC,Ontology_term=0008879/note:identified by similarity of predicted tertiary structure to PDB 1g3lD,3hl3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1g3lD,3hl3A,Ontology_term=0008878/note:identified by similarity of predicted tertiary structure to PDB 1yp3C,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yp3C,5l6sA,Ontology_term=1900727/note:identified by similarity of predicted tertiary structure to PDB 2e3dC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2e3dC,Ontology_term=0009245/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,Ontology_term=0009244/note:identified by similarity of predicted tertiary structure to PDB 1g3lD,2e3dC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1g3lD,2e3dC,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,4kt7A,2xwlA,4cvhA,1vpaA,1i52A,1hm8A,2vsiB,5l6sA,5ddtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,4kt7A,2xwlA,4cvhA,1vpaA,1i52A,1hm8A,2vsiB,5l6sA,5ddtA,Ontology_term=0009058/note:identified by similarity of predicted tertiary structure to PDB 1g3lD,1yp3C,3hl3A,5i1fA,1wvcA,1hm8A,2e3dC,2pa4B,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1g3lD,1yp3C,3hl3A,5i1fA,1wvcA,1hm8A,2e3dC,2pa4B,5l6sA,Ontology_term=0008360/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A,2yqjA,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,2yqjA,5l6sA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0006048/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,1hm8A,2yqjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,1hm8A,2yqjA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 3fwwA,2w0wA,3d8vA,4kt7A,2y6pA,1g3lD,1yp3C,3hl3A,2xwlA,4cvhA,1vpaA,5i1fA,1wvcA,1i52A,1hm8A,2e3dC,2yqjA,2pa4B,5l6sA,5ddtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fwwA,2w0wA,3d8vA,4kt7A,2y6pA,1g3lD,1yp3C,3hl3A,2xwlA,4cvhA,1vpaA,5i1fA,1wvcA,1i52A,1hm8A,2e3dC,2yqjA,2pa4B,5l6sA,5ddtA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5l6sA,Ontology_term=0006486/note:identified by similarity of predicted tertiary structure to PDB 4cvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cvhA,Ontology_term=0005977/note:identified by similarity of predicted tertiary structure to PDB 5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5l6sA,Ontology_term=0005978/note:identified by similarity of predicted tertiary structure to PDB 1yp3C,5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yp3C,5l6sA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4cvhA,1i52A,2e3dC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cvhA,1i52A,2e3dC,Ontology_term=0070567/note:identified by similarity of predicted tertiary structure to PDB 4kt7A,2xwlA,4cvhA,1vpaA,1i52A,2vsiB,5ddtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kt7A,2xwlA,4cvhA,1vpaA,1i52A,2vsiB,5ddtA,Ontology_term=0008299/note:identified by similarity of predicted tertiary structure to PDB 4kt7A,2xwlA,4cvhA,1vpaA,1i52A,2vsiB,5ddtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kt7A,2xwlA,4cvhA,1vpaA,1i52A,2vsiB,5ddtA,Ontology_term=0047343/note:identified by similarity of predicted tertiary structure to PDB 1wvcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wvcA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 5l6sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5l6sA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3d8vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,Ontology_term=0047349/note:identified by similarity of predicted tertiary structure to PDB 4cvhA,2vsiB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cvhA,2vsiB,Ontology_term=0016114/note:identified by similarity of predicted tertiary structure to PDB 2xwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xwlA,Ontology_term=0019305/note:identified by similarity of predicted tertiary structure to PDB 1g3lD,3hl3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1g3lD,3hl3A,Ontology_term=0070569/note:identified by similarity of predicted tertiary structure to PDB 3d8vA,2yqjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3d8vA,2yqjA chr1 CDS 448630 449385 . - . ID=CDS1;locus_tag=Rv0372c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, potential NAD-binding protein. Aligns to only 1 of 2 XdhC-CoxI domains (IPR003777) in a xanthine dehydrogenase of M. smegmatis and lacks the XdhC Rossman domain. The single XdhC-CoxI domain may signify an NAD-binding site. chr1 CDS 449404 451803 . - . ID=CDS1;locus_tag=Rv0373c;product=Probable carbon monoxide dehydrogenase (large chain);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 451800 452279 . - . ID=CDS1;locus_tag=Rv0374c;product=Probable carbon monoxide dehydrogenase (small chain);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 452294 453154 . - . ID=CDS1;locus_tag=Rv0375c;product=Probable carbon monoxide dehydrogenase (medium chain);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 453230 454372 . - . ID=CDS1;locus_tag=Rv0376c;product=Probable Xanthine dehydrogenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.17.1.4 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:2we7A/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 454421 455386 . + . ID=CDS1;locus_tag=Rv0377;product=Probable transcriptional regulatory protein (probably LysR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 455637 455858 . + . ID=CDS1;locus_tag=Rv0378;product=Conserved hypothetical glycine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 455977 456192 . + . ID=CDS1;locus_tag=Rv0379;product=Possible protein transport protein SecE2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 456268 456819 . - . ID=CDS1;locus_tag=Rv0380c;product=Possible RNA methyltransferase (RNA methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 456915 457823 . - . ID=CDS1;locus_tag=Rv0381c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 457841 458380 . - . ID=CDS1;locus_tag=Rv0382c;product=Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 458461 459315 . - . ID=CDS1;locus_tag=Rv0383c;product=Possible conserved secreted protein;note=FunctionalCategory: cell wall and cell processes;Experiment=EXISTENCE:co-immunoprecipitation [PMID: 24248369]/note:binding partner of VirR (Rv0431) [PMID: 24248369]/note:protein complex putatively involved in the regulation of extracellular vesicle formation [PMID: 24248369] chr1 CDS 459456 462002 . - . ID=CDS1;locus_tag=Rv0384c;product=Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 462135 463307 . + . ID=CDS1;locus_tag=Rv0385;product=Probable monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 463411 466668 . + . ID=CDS1;locus_tag=Rv0386;product=Probable transcriptional regulatory protein (probably LuxR/UhpA-family);note=FunctionalCategory: regulatory proteins chr1 CDS 466672 467406 . - . ID=CDS1;locus_tag=Rv0387c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 467459 468001 . - . ID=CDS1;locus_tag=Rv0388c;gene=PPE9;product=PPE family protein PPE9;note=FunctionalCategory: PE/PPE chr1 CDS 468335 469594 . + . ID=CDS1;locus_tag=Rv0389;product=Probable phosphoribosylglycinamide formyltransferase 2 PurT (GART 2) (gar transformylase 2) (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 469591 470013 . + . ID=CDS1;locus_tag=Rv0390;product=Conserved protein/Putative sulfurtransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.8.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3ippB,1orbA,1gn0A,1uarA,1h4kX,3utnX,1yt8A,3i2vA,3hzuA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0002098/note:identified by similarity of predicted tertiary structure to PDB 3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3utnX,Ontology_term=0051029/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0004792/note:identified by similarity of predicted tertiary structure to PDB 3ippB,1orbA,1gn0A,1uarA,1h4kX,3utnX,1yt8A,3hzuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ippB,1orbA,1gn0A,1uarA,1h4kX,3utnX,1yt8A,3hzuA,Ontology_term=0002143/note:identified by similarity of predicted tertiary structure to PDB 3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3utnX,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3utnX,Ontology_term=0005615/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0035928/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1orbA,3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,3utnX,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1orbA,1gn0A,1uarA,1h4kX,3utnX,1yt8A,3hzuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,1gn0A,1uarA,1h4kX,3utnX,1yt8A,3hzuA,Ontology_term=0030855/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0008097/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0005743/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1orbA,1h4kX,3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,1h4kX,3utnX chr1 CDS 469998 471230 . + . ID=CDS1;locus_tag=Rv0391;product=Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 471227 472639 . - . ID=CDS1;locus_tag=Rv0392c;product=Probable membrane NADH dehydrogenase NdhA;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 472781 474106 . + . ID=CDS1;locus_tag=Rv0393;product=Conserved 13E12 repeat family protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 474122 474841 . - . ID=CDS1;locus_tag=Rv0394c;product=Hyaluronidase/ Chondrosulfatase;Experiment=DESCRIPTION:expression and purification of recombinant Rv0394c, western blotting, MALDI-TOF, in vitro hyaluronidase and chondrosulfatase activity assays [PMID: 23465892]/note:FunctionalCategory: cell wall and cell processes/note:responsible for utilizing hyaluronan as alternative carbon source [PMID: 23465892];EC_number=3.1.6.12,EC_number=3.2.1.35 chr1 CDS 474940 475344 . + . ID=CDS1;locus_tag=Rv0395;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 475350 475742 . + . ID=CDS1;locus_tag=Rv0396;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 475816 476184 . + . ID=CDS1;locus_tag=Rv0397;product=Conserved 13E12 repeat family protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 476394 476642 . + . ID=CDS1;locus_tag=Rv0397A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 476679 477320 . - . ID=CDS1;locus_tag=Rv0398c;product=Possible secreted protein;note=FunctionalCategory: cell wall and cell processes, up-regulated after 24 hours of starvation, suggested to play a role in maintaining long-term survival within host [PMID: 22324751] chr1 CDS 477327 478556 . - . ID=CDS1;locus_tag=Rv0399c;product=Possible conserved lipoprotein LpqK;note=FunctionalCategory: cell wall and cell processes chr1 CDS 478566 479753 . - . ID=CDS1;locus_tag=Rv0400c;product=Acyl-CoA dehydrogenase FadE7;note=FunctionalCategory: lipid metabolism chr1 CDS 479789 480160 . + . ID=CDS1;locus_tag=Rv0401;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 480355 483231 . - . ID=CDS1;locus_tag=Rv0402c;product=Probable conserved transmembrane transport protein MmpL1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 483228 483656 . - . ID=CDS1;locus_tag=Rv0403c;product=Probable conserved membrane protein MmpS1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 483977 485734 . + . ID=CDS1;locus_tag=Rv0404;product=Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 485731 489939 . + . ID=CDS1;locus_tag=Rv0405;product=Probable membrane bound polyketide synthase Pks6;note=FunctionalCategory: lipid metabolism chr1 CDS 489887 490705 . - . ID=CDS1;locus_tag=Rv0406c;product=Beta lactamase like protein/Putative cyclic amide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5aebA,2fhxA,1ko3A,2gmnA,3vpeA,3faiA,3q6xA,1l9yA,1a7tA,4hl1A,5iqkA,2fu9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2fhxA,1ko3A,3faiA,3q6xA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fhxA,1ko3A,3faiA,3q6xA,4hl1A,2fu9A,Ontology_term=0008800/note:identified by similarity of predicted tertiary structure to PDB 2fhxA,3faiA,3q6xA,1a7tA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fhxA,3faiA,3q6xA,1a7tA,4hl1A,2fu9A,Ontology_term=0017001/note:identified by similarity of predicted tertiary structure to PDB 2fhxA,3faiA,3q6xA,1a7tA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fhxA,3faiA,3q6xA,1a7tA,4hl1A,2fu9A,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 3faiA,3q6xA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3faiA,3q6xA,4hl1A,2fu9A,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 2fhxA,3faiA,3q6xA,1a7tA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fhxA,3faiA,3q6xA,1a7tA,4hl1A,2fu9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 5aebA,2fhxA,1ko3A,2gmnA,3vpeA,3faiA,3q6xA,4hl1A,5iqkA,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5aebA,2fhxA,1ko3A,2gmnA,3vpeA,3faiA,3q6xA,4hl1A,5iqkA,2fu9A,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 3faiA,3q6xA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3faiA,3q6xA,4hl1A,2fu9A chr1 CDS 490783 491793 . + . ID=CDS1;locus_tag=Rv0407;product=F420-dependent glucose-6-phosphate dehydrogenase Fgd1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 491786 493858 . + . ID=CDS1;locus_tag=Rv0408;product=Probable phosphate acetyltransferase Pta (phosphotransacetylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 493851 495008 . + . ID=CDS1;locus_tag=Rv0409;product=Probable acetate kinase AckA (acetokinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 495062 497314 . - . ID=CDS1;locus_tag=Rv0410c;product=Serine/threonine-protein kinase PknG (protein kinase G) (STPK G);note=FunctionalCategory: regulatory proteins chr1 CDS 497314 498300 . - . ID=CDS1;locus_tag=Rv0411c;product=Probable glutamine-binding lipoprotein GlnH (GLNBP);note=FunctionalCategory: cell wall and cell processes chr1 CDS 498300 499619 . - . ID=CDS1;locus_tag=Rv0412c;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes, up-regulated in the presence of isoniazid, isoxyl [PMID: 15207496] and ethionamide [PMID: 16246625], possibly regulated by RecA-NDp [PMID: 15336403];Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 499713 500366 . + . ID=CDS1;locus_tag=Rv0413;product=Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase);note=FunctionalCategory: information pathways chr1 CDS 500350 501018 . - . ID=CDS1;locus_tag=Rv0414c;product=Thiamine-phosphate pyrophosphorylase ThiE (TMP pyrophosphorylase) (TMP-PPASE) (thiamine-phosphate synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 501148 502170 . + . ID=CDS1;locus_tag=Rv0415;product=Possible thiamine biosynthesis oxidoreductase ThiO;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 502167 502373 . + . ID=CDS1;locus_tag=Rv0416;gene=thiS;product=Possible protein ThiS/putative transferase;Inference=similar to AA sequence:COG:2104 [PMID: 15642267]/note:FunctionalCategory: intermediary metabolism and respiration/note:predicted to be involved in thiamine biosynthesis [PMID: 15642267];EC_number=2.-.-.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1wgkA,2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wgkA,2ax5A,Ontology_term=0006777/note:identified by similarity of predicted tertiary structure to PDB 1nviD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nviD,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2ax5A,1nviD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,1nviD,Ontology_term=0031386/note:identified by similarity of predicted tertiary structure to PDB 3po0A,2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3po0A,2ax5A,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 1wgkA,2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wgkA,2ax5A,Ontology_term=0016783/note:identified by similarity of predicted tertiary structure to PDB 1wgkA,2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wgkA,2ax5A,Ontology_term=0002098/note:identified by similarity of predicted tertiary structure to PDB 1wgkA,2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wgkA,2ax5A,Ontology_term=0034227/note:identified by similarity of predicted tertiary structure to PDB 1wgkA,2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wgkA,2ax5A,Ontology_term=0001403/note:identified by similarity of predicted tertiary structure to PDB 2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3po0A,2m19A,1tygB,1nviD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3po0A,2m19A,1tygB,1nviD,Ontology_term=0032447/note:identified by similarity of predicted tertiary structure to PDB 2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,Ontology_term=0032446/note:identified by similarity of predicted tertiary structure to PDB 3po0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3po0A,Ontology_term=0007114/note:identified by similarity of predicted tertiary structure to PDB 2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2ax5A,1nviD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,1nviD,Ontology_term=0009229/note:identified by similarity of predicted tertiary structure to PDB 1tygB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tygB,Ontology_term=0034599/note:identified by similarity of predicted tertiary structure to PDB 2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,Ontology_term=0009228/note:identified by similarity of predicted tertiary structure to PDB 1tygB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tygB,Ontology_term=0002143/note:identified by similarity of predicted tertiary structure to PDB 2ax5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax5A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1wgkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wgkA chr1 CDS 502366 503124 . + . ID=CDS1;locus_tag=Rv0417;product=Probable thiamin biosynthesis protein ThiG (thiazole biosynthesis protein);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 503496 504998 . + . ID=CDS1;locus_tag=Rv0418;product=Probable lipoprotein aminopeptidase LpqL;note=FunctionalCategory: cell wall and cell processes chr1 CDS 505086 506582 . + . ID=CDS1;locus_tag=Rv0419;product=Possible lipoprotein peptidase LpqM;note=FunctionalCategory: cell wall and cell processes chr1 CDS 506561 506971 . - . ID=CDS1;locus_tag=Rv0420c;product=Possible transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 507132 507761 . - . ID=CDS1;locus_tag=Rv0421c;product=esterase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:protein purification and characterization, enzyme activity assay [PMID: 27050490],Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/inference:ab initio prediction:3D structure prediction using YASARA and PROCHECK, in silico docking studies [PMID: 27050490];EC_number=3.1.-.-,EC_number=1.11.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1a8qA,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.4.19.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4hxeB,1ve6A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4hxeB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hxeB,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,1a8sA,1a88A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1ve6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ve6A,Ontology_term=0005198/note:identified by similarity of predicted tertiary structure to PDB 3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vdxA,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,1a8sA,1a88A,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 4hxeB,1ve6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hxeB,1ve6A,Ontology_term=0008236/note:identified by similarity of predicted tertiary structure to PDB 4hxeB,1ve6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hxeB,1ve6A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1ve6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ve6A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,1a8sA,1a88A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,1a8sA,1a88A,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vdxA,Ontology_term=0016691/note:identified by similarity of predicted tertiary structure to PDB 1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8sA,1a88A,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,1a8sA,1a88A chr1 CDS 507758 508555 . - . ID=CDS1;locus_tag=Rv0422c;product=Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 508582 510225 . - . ID=CDS1;locus_tag=Rv0423c;product=Probable thiamine biosynthesis protein ThiC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 510377 510652 . - . ID=CDS1;locus_tag=Rv0424c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 510702 515321 . - . ID=CDS1;locus_tag=Rv0425c;product=Possible metal cation transporting P-type ATPase CtpH;note=FunctionalCategory: cell wall and cell processes chr1 CDS 515373 515816 . - . ID=CDS1;locus_tag=Rv0426c;product=Possible transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 516017 516892 . - . ID=CDS1;locus_tag=Rv0427c;product=Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI);note=FunctionalCategory: information pathways chr1 CDS 516895 517803 . - . ID=CDS1;locus_tag=Rv0428c;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 517803 518396 . - . ID=CDS1;locus_tag=Rv0429c;product=Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase);note=FunctionalCategory: information pathways chr1 CDS 518733 519041 . + . ID=CDS1;locus_tag=Rv0430;product=Conserved hypothetical protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:08694 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in tuberculin secretion [PMID: 22485162] chr1 CDS 519073 519567 . + . ID=CDS1;locus_tag=Rv0431;gene=virR;product=probable vesiculogenesis/immune response regulator;Experiment=DESCRIPTION:gene knockout, NMR spectroscopy, scanning electron microscopy [PMID: 24248369],Experiment=DESCRIPTION:gene knockout, infection of macrophage, mouse infections [PMID: 21170273]/note:FunctionalCategory: cell wall and cell processes/note:Putative tuberculin related peptide [PMID: 17436267]/note:possibly regulate membrane vesicle formation in M. tuberculosis [PMID: 24248369]/note:suppresses TNF-alpha, IL12p40 and IL-6 production in primary macrophages [PMID: 21170273]/note:co-immunoprecipitation studies identified LpqH, Rv1488 and Rv0383c as binding partners of VirR (Rv0431) [PMID: 26324094]/note:probably mediates immune evasion of and alters cytokine production of macrophages [PMID: 27765619] chr1 CDS 519600 520322 . + . ID=CDS1;locus_tag=Rv0432;product=Periplasmic superoxide dismutase [Cu-Zn] SodC;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 520324 521454 . + . ID=CDS1;locus_tag=Rv0433;product=Putative peptide synthase;note=FunctionalCategory: conserved hypotheticals;EC_number=6.3.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2gwcF,3nztA,3ln7A,3ln6A,2d33A,3ig5A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3ln7A,3ln6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ln7A,3ln6A,Ontology_term=0042398/note:identified by similarity of predicted tertiary structure to PDB 2gwcF/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gwcF,Ontology_term=0017109/note:identified by similarity of predicted tertiary structure to PDB 3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ig5A,Ontology_term=0071243/note:identified by similarity of predicted tertiary structure to PDB 2d33A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d33A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ig5A,Ontology_term=0004363/note:identified by similarity of predicted tertiary structure to PDB 3ln7A,3ln6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ln7A,3ln6A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3nztA,3ln7A,3ln6A,2d33A,3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nztA,3ln7A,3ln6A,2d33A,3ig5A,Ontology_term=0046686/note:identified by similarity of predicted tertiary structure to PDB 3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ig5A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3ln7A,3ln6A,2d33A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ln7A,3ln6A,2d33A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3nztA,3ln7A,3ln6A,2d33A,3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nztA,3ln7A,3ln6A,2d33A,3ig5A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3ln7A,3ln6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ln7A,3ln6A,Ontology_term=0006972/note:identified by similarity of predicted tertiary structure to PDB 2d33A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d33A,Ontology_term=0016874/note:identified by similarity of predicted tertiary structure to PDB 3nztA,3ln7A,3ln6A,2d33A,3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nztA,3ln7A,3ln6A,2d33A,3ig5A,Ontology_term=0042542/note:identified by similarity of predicted tertiary structure to PDB 3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ig5A,Ontology_term=0071288/note:identified by similarity of predicted tertiary structure to PDB 2d33A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d33A,Ontology_term=0004357/note:identified by similarity of predicted tertiary structure to PDB 2gwcF,3nztA,3ln7A,3ln6A,2d33A,3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gwcF,3nztA,3ln7A,3ln6A,2d33A,3ig5A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2d33A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d33A,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ig5A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ig5A,Ontology_term=0006750/note:identified by similarity of predicted tertiary structure to PDB 2gwcF,3nztA,3ln7A,3ln6A,2d33A,3ig5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gwcF,3nztA,3ln7A,3ln6A,2d33A,3ig5A chr1 CDS 521514 522167 . + . ID=CDS1;locus_tag=Rv0434;product=Putative serine endopeptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.21.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3ljcA,3m65A/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 522347 524533 . - . ID=CDS1;locus_tag=Rv0435c;product=Putative conserved ATPase;note=FunctionalCategory: cell wall and cell processes chr1 CDS 524530 525390 . - . ID=CDS1;locus_tag=Rv0436c;product=Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 525387 526082 . - . ID=CDS1;locus_tag=Rv0437c;product=Possible phosphatidylserine decarboxylase Psd (PS decarboxylase);note=FunctionalCategory: lipid metabolism chr1 CDS 526143 527360 . - . ID=CDS1;locus_tag=Rv0438c;product=Probable molybdopterin biosynthesis protein MoeA2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 527379 528314 . - . ID=CDS1;locus_tag=Rv0439c;product=Probable dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 528608 530230 . + . ID=CDS1;locus_tag=Rv0440;product=60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (antigen A);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 530296 530724 . - . ID=CDS1;locus_tag=Rv0441c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 530751 532214 . - . ID=CDS1;locus_tag=Rv0442c;gene=PPE10;product=PPE family protein PPE10;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642]/note:identified by similarity of predicted tertiary structure to PDB:4ut1A/inference:ab initio prediction:I-TASSER:5.1/note:possible flagellar-hook protein/note:Very strong structural similarity to a flagellar-hook protein chr1 CDS 532396 532911 . + . ID=CDS1;locus_tag=Rv0443;product=Mycothiol S-transferase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:protein purification and characterization, assay of MST activity [PMID: 22059487];EC_number=2.5.-.-,EC_number=assignment. I think it needs a new one created, but I'm not sure what/note:Contradicts assignment of chorismate synthase on UniProt chr1 CDS 533091 533789 . - . ID=CDS1;locus_tag=Rv0444c;product=Anti-sigma factor RskA (regulator of sigma K);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 533833 534396 . - . ID=CDS1;locus_tag=Rv0445c;product=Alternative RNA polymerase sigma factor SigK;note=FunctionalCategory: information pathways chr1 CDS 534445 535215 . - . ID=CDS1;locus_tag=Rv0446c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, induced by INH [PMID: 21426023] chr1 CDS 535224 536507 . - . ID=CDS1;locus_tag=Rv0447c;product=Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 536504 537169 . - . ID=CDS1;locus_tag=Rv0448c;product=Conserved hypothetical protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:COG:3496 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in lipid biosynthetic processes [PMID: 22485162] chr1 CDS 537229 538548 . - . ID=CDS1;locus_tag=Rv0449c;product=Putative oxidoreductase;Experiment=northern blotting, luciferase assay [PMID: 18203833]/inference:similar to AA sequence:BLAST [PMID: 18203833]/note:FunctionalCategory: conserved hypotheticals/note:Regulated by SigK [PMID: 18203833];EC_number=1.3.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2iveA,1sezA,3nksA,3i6dB,3lovA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006779/note:identified by similarity of predicted tertiary structure to PDB 2iveA,1sezA,3nksA,3i6dB,3lovA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,1sezA,3nksA,3i6dB,3lovA,Ontology_term=0006783/note:identified by similarity of predicted tertiary structure to PDB 2iveA,1sezA,3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,1sezA,3nksA,Ontology_term=0006782/note:identified by similarity of predicted tertiary structure to PDB 2iveA,1sezA,3nksA,3i6dB,3lovA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,1sezA,3nksA,3i6dB,3lovA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2iveA,3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,3nksA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3lovA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3lovA,Ontology_term=0046501/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA,Ontology_term=0031966/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2iveA,1sezA,3nksA,3i6dB,3lovA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,1sezA,3nksA,3i6dB,3lovA,Ontology_term=0004729/note:identified by similarity of predicted tertiary structure to PDB 2iveA,1sezA,3nksA,3i6dB,3lovA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,1sezA,3nksA,3i6dB,3lovA,Ontology_term=0031305/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA,Ontology_term=0031304/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2iveA,1sezA,3nksA,3i6dB,3lovA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,1sezA,3nksA,3i6dB,3lovA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2iveA,3i6dB,3lovA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iveA,3i6dB,3lovA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1sezA,3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sezA,3nksA,Ontology_term=0042493/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA,Ontology_term=0005743/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA,Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA,Ontology_term=0005758/note:identified by similarity of predicted tertiary structure to PDB 3nksA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nksA chr1 CDS 538588 541491 . - . ID=CDS1;locus_tag=Rv0450c;product=Probable conserved transmembrane transport protein MmpL4;note=FunctionalCategory: cell wall and cell processes chr1 CDS 541488 541910 . - . ID=CDS1;locus_tag=Rv0451c;product=Probable conserved membrane protein MmpS4;note=FunctionalCategory: cell wall and cell processes chr1 CDS 542142 542852 . + . ID=CDS1;locus_tag=Rv0452;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins, Probably regulated by Rv1404 and is induced inside macrophage [PMID: 26615221], Up-regulated on exposure to rifampicin [PMID: 23182912];Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2zcxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zcxA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2zcxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zcxA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2zcxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zcxA,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 2zcxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zcxA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2zcxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zcxA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2zcxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zcxA chr1 CDS 543174 544730 . + . ID=CDS1;locus_tag=Rv0453;gene=PPE11;product=PPE family protein PPE11;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642],Experiment=EXISTENCE:2D gel electrophoresis, liquid chromatography mass spectrometry [PMID: 17443846]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection. [PMID: 21085642]/note:probably secreted, found expressed in the culture filtrate [PMID: 17443846]/note:enhances biofilm growth [PMID: 28036246]/note:potential endotoxin/note:structurally similar to many endotoxins/note:identified by similarity of predicted tertiary structure to PDB 1ciyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ciyA chr1 CDS 544835 545185 . + . ID=CDS1;locus_tag=Rv0454;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 545375 545821 . - . ID=CDS1;locus_tag=Rv0455c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 545889 546803 . - . ID=CDS1;locus_tag=Rv0456c;product=enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 547076 547357 . - . ID=CDS1;locus_tag=Rv0456A;product=Possible toxin MazF1;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 547344 547517 . - . ID=CDS1;locus_tag=Rv0456B;product=Possible antitoxin MazE1;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 547586 549607 . - . ID=CDS1;locus_tag=Rv0457c;product=Probable peptidase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 549675 551198 . + . ID=CDS1;locus_tag=Rv0458;product=Probable aldehyde dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 551198 551689 . + . ID=CDS1;locus_tag=Rv0459;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 551749 551988 . + . ID=CDS1;locus_tag=Rv0460;product=Conserved hydrophobic protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:47585 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in membrane associated processes [PMID: 22485162] chr1 CDS 552026 552550 . + . ID=CDS1;locus_tag=Rv0461;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 552614 554008 . + . ID=CDS1;locus_tag=Rv0462;product=Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 554016 554309 . + . ID=CDS1;locus_tag=Rv0463;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 554313 554885 . - . ID=CDS1;locus_tag=Rv0464c;product=Conserved protein/putative peroxiredoxin;note=FunctionalCategory: conserved hypotheticals;EC_number=1.11.1.-;Ontology_term=0016209/note:identified by similarity of predicted tertiary structure to PDB 2oyoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2oyoA,Ontology_term=0051920/note:identified by similarity of predicted tertiary structure to PDB 2oyoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2oyoA,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 2oyoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2oyoA,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 2oyoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2oyoA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2oyoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2oyoA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2oyoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2oyoA chr1 CDS 554882 556306 . - . ID=CDS1;locus_tag=Rv0465c;gene=lrpI;product=Transcriptional regulatory protein, local regulatory protein of icl1;Experiment=DESCRIPTION:Transposon-insertion mutagenesis and complementation [PMID: 21193605]/note:FunctionalCategory: regulatory proteins/note:Alternatively referred to as ramB, regulator of acetate metabolism [PMID: 19767422]/note:Necessary for induction of the glyoxylate shunt in H37Rv [PMID: 21193605]/note:Controlled by sigma factor E [PMID: 21193605]/note:Represses icl1 during growth on glucose [PMID: 21193605]/note:Possibly regulated by sigB, induction of Rv0465c was abolished by a sigB mutation and was decreased by a sigE mutation [PMID: 21193605] chr1 CDS 556458 557252 . + . ID=CDS1;locus_tag=Rv0466;product=Conserved protein/Putative thiolester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2ownB,4zv3A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006633/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016790/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0004320/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016295/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016296/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016297/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB chr1 CDS 557527 558813 . + . ID=CDS1;locus_tag=Rv0467;product=Isocitrate lyase Icl (isocitrase) (isocitratase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 558895 559755 . + . ID=CDS1;locus_tag=Rv0468;product=3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD);note=FunctionalCategory: lipid metabolism chr1 CDS 559888 560748 . + . ID=CDS1;locus_tag=Rv0469;product=Possible mycolic acid synthase UmaA;note=FunctionalCategory: lipid metabolism chr1 CDS 560848 561711 . - . ID=CDS1;locus_tag=Rv0470c;product=Mycolic acid synthase PcaA (cyclopropane synthase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 561854 562294 . - . ID=CDS1;locus_tag=Rv0470A;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 562225 562713 . - . ID=CDS1;locus_tag=Rv0471c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 562723 563427 . - . ID=CDS1;locus_tag=Rv0472c;product=Probable transcriptional regulatory protein (possibly TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 563564 564934 . + . ID=CDS1;locus_tag=Rv0473;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 565021 565443 . + . ID=CDS1;locus_tag=Rv0474;product=Probable transcriptional regulatory protein/putative transcriptional regulator;note=FunctionalCategory: regulatory proteins, upregulated during reactivation of Mtb from dormancy [PMID: 26025969];Ontology_term=0043565/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA,Ontology_term=0030435/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA,Ontology_term=0010629/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA,Ontology_term=0046983/note:identified by similarity of predicted tertiary structure to PDB 1b0nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b0nA chr1 CDS 565797 566396 . + . ID=CDS1;locus_tag=Rv0475;product=Iron-regulated heparin binding hemagglutinin HbhA (adhesin);note=FunctionalCategory: cell wall and cell processes chr1 CDS 566508 566771 . + . ID=CDS1;locus_tag=Rv0476;product=Probable antigen;Experiment=DESCRIPTION: protein purification, Indirect ELISA [PMID: 20690665]/note:FunctionalCategory: cell wall and cell processes/note:Possible conserved transmembrane protein [TubercuList] chr1 CDS 566776 567222 . + . ID=CDS1;locus_tag=Rv0477;product=Possible conserved secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 567222 567896 . + . ID=CDS1;locus_tag=Rv0478;product=Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 567921 568967 . - . ID=CDS1;locus_tag=Rv0479c;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes, phosphorylated by PknJ [PMID: 20185505];Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 568964 569806 . - . ID=CDS1;locus_tag=Rv0480c;product=Possible amidohydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 569988 570512 . - . ID=CDS1;locus_tag=Rv0481c;product=Hypothetical protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:43594 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in membrane associated processes [PMID: 22485162] chr1 CDS 570539 571648 . + . ID=CDS1;locus_tag=Rv0482;product=Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 571710 573065 . + . ID=CDS1;locus_tag=Rv0483;product=Probable conserved lipoprotein LprQ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 573046 573801 . - . ID=CDS1;locus_tag=Rv0484c;product=Probable short-chain type oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 573984 575300 . + . ID=CDS1;locus_tag=Rv0485;product=Possible transcriptional regulatory protein/Putative transcriptional regulator;Experiment=DESCRIPTION: Transposon mutagenesis, microarray expression analysis, mouse infection, macrophage infection [PMID: 19651861]/note:FunctionalCategory: regulatory proteins/note:Regulates the expression of PE13 and PPE18 gene pair (Rv1195 and Rv1196) [PMID: 19651861]/note:Disruption Rv0485 results in reduced expression of pe13 and ppe18 and attenuation of M. tuberculosis virulence [PMID: 19651861]/note:sRNA Mcr19 is identified to be located within the ORF of this gene [PMID: 20181675];Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1z6rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z6rA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 1z6rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z6rA,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 1z05A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z05A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1z05A,1z6rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z05A,1z6rA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1z6rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z6rA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1z6rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z6rA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1z6rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z6rA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1z05A,1z6rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z05A,1z6rA chr1 CDS 575348 576790 . + . ID=CDS1;locus_tag=Rv0486;product=Glycosyltransferase MshA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 576787 577338 . + . ID=CDS1;locus_tag=Rv0487;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 577664 578269 . + . ID=CDS1;locus_tag=Rv0488;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 578426 579175 . + . ID=CDS1;locus_tag=Rv0489;product=Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 579349 580581 . + . ID=CDS1;locus_tag=Rv0490;product=Putative two component sensor histidine kinase SenX3;note=FunctionalCategory: regulatory proteins chr1 CDS 580809 581492 . + . ID=CDS1;locus_tag=Rv0491;product=Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 581489 583378 . - . ID=CDS1;locus_tag=Rv0492c;product=Probable oxidoreductase GMC-type;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 583375 583704 . - . ID=CDS1;locus_tag=Rv0492A;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 583701 584690 . - . ID=CDS1;locus_tag=Rv0493c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 584695 585423 . + . ID=CDS1;locus_tag=Rv0494;product=Probable transcriptional regulatory protein (probably GntR-family);note=FunctionalCategory: regulatory proteins;Experiment=DESCRIPTION:overexpression in M.bovis, qRT-PCR [PMID: 23475950] chr1 CDS 585424 586314 . - . ID=CDS1;locus_tag=Rv0495c;product=Conserved hypothetical protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:05481 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in DNA-associated processes [PMID: 22485162] chr1 CDS 586394 587380 . + . ID=CDS1;locus_tag=Rv0496;product=Exopolyphosphatase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Protein expression and purification, spectrophotometric phosphate release assay, exopolyphosphatase assay [PMID: 22880033];EC_number=3.6.1.11 chr1 CDS 587377 588309 . + . ID=CDS1;locus_tag=Rv0497;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 588325 589167 . + . ID=CDS1;locus_tag=Rv0498;product=Putative sugar isomerase;note=FunctionalCategory: conserved hypotheticals;EC_number=5.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3vniA,3cqiA,2ou4A/inference:ab initio prediction:I-TASSER:5.1,EC_number=5.3.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1a0dA,5xinA,3p14A,1bxcA,3ktcA,1didA,4xkmA,1de5A,3vylA,1a0eA,1qt1A,2i57C,4gjiA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0019324/note:identified by similarity of predicted tertiary structure to PDB 1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1de5A,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1de5A,Ontology_term=0008740/note:identified by similarity of predicted tertiary structure to PDB 3p14A,1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3p14A,1de5A,Ontology_term=0034015/note:identified by similarity of predicted tertiary structure to PDB 3cqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cqiA,Ontology_term=0006098/note:identified by similarity of predicted tertiary structure to PDB 1a0dA,5xinA,1bxcA,1didA,4xkmA,1a0eA,1qt1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0dA,5xinA,1bxcA,1didA,4xkmA,1a0eA,1qt1A,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1de5A,Ontology_term=0009045/note:identified by similarity of predicted tertiary structure to PDB 1a0dA,5xinA,1bxcA,3ktcA,1didA,4xkmA,1a0eA,1qt1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0dA,5xinA,1bxcA,3ktcA,1didA,4xkmA,1a0eA,1qt1A,Ontology_term=0016861/note:identified by similarity of predicted tertiary structure to PDB 3cqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cqiA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1a0dA,5xinA,3p14A,1bxcA,1didA,4xkmA,1de5A,1a0eA,1qt1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0dA,5xinA,3p14A,1bxcA,1didA,4xkmA,1de5A,1a0eA,1qt1A,Ontology_term=0019854/note:identified by similarity of predicted tertiary structure to PDB 3cqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cqiA,Ontology_term=0042843/note:identified by similarity of predicted tertiary structure to PDB 4xkmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4xkmA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3vniA,2ou4A,1a0dA,5xinA,3p14A,1bxcA,3ktcA,1didA,4xkmA,1de5A,3vylA,1a0eA,1qt1A,2i57C,4gjiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vniA,2ou4A,1a0dA,5xinA,3p14A,1bxcA,3ktcA,1didA,4xkmA,1de5A,3vylA,1a0eA,1qt1A,2i57C,4gjiA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1de5A,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1de5A,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 3vniA,3p14A,1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vniA,3p14A,1de5A,Ontology_term=0019299/note:identified by similarity of predicted tertiary structure to PDB 3p14A,1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3p14A,1de5A,Ontology_term=0033296/note:identified by similarity of predicted tertiary structure to PDB 1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1de5A,Ontology_term=0042732/note:identified by similarity of predicted tertiary structure to PDB 1a0dA,5xinA,1bxcA,1didA,4xkmA,1a0eA,1qt1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0dA,5xinA,1bxcA,1didA,4xkmA,1a0eA,1qt1A,Ontology_term=0016857/note:identified by similarity of predicted tertiary structure to PDB 3vniA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vniA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3cqiA,1a0dA,5xinA,1bxcA,3ktcA,1didA,4xkmA,1a0eA,1qt1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cqiA,1a0dA,5xinA,1bxcA,3ktcA,1didA,4xkmA,1a0eA,1qt1A,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 3vniA,3cqiA,2ou4A,1a0dA,5xinA,3p14A,1bxcA,3ktcA,1didA,4xkmA,1de5A,1a0eA,1qt1A,2i57C,4gjiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vniA,3cqiA,2ou4A,1a0dA,5xinA,3p14A,1bxcA,3ktcA,1didA,4xkmA,1de5A,1a0eA,1qt1A,2i57C,4gjiA,Ontology_term=0050897/note:identified by similarity of predicted tertiary structure to PDB 3vniA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vniA,Ontology_term=0019301/note:identified by similarity of predicted tertiary structure to PDB 3p14A,1de5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3p14A,1de5A chr1 CDS 589183 590058 . + . ID=CDS1;locus_tag=Rv0499;product=Putative thiolester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1c8uA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006637/note:identified by similarity of predicted tertiary structure to PDB 1c8uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c8uA,Ontology_term=0009062/note:identified by similarity of predicted tertiary structure to PDB 1c8uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c8uA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1c8uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c8uA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1c8uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c8uA,Ontology_term=0047617/note:identified by similarity of predicted tertiary structure to PDB 1c8uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c8uA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1c8uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c8uA chr1 CDS 590083 590970 . + . ID=CDS1;locus_tag=Rv0500;product=Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 591111 591347 . + . ID=CDS1;locus_tag=Rv0500A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 591475 591576 . + . ID=CDS1;locus_tag=Rv0500B;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 591654 592784 . + . ID=CDS1;locus_tag=Rv0501;product=Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 592791 593867 . + . ID=CDS1;locus_tag=Rv0502;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 593871 594779 . - . ID=CDS1;locus_tag=Rv0503c;product=Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 594802 595302 . - . ID=CDS1;locus_tag=Rv0504c;product=Conserved protein/Probable 3-hydroxyacyl-[acyl-carrier-protein] dehydratase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.2.1.59 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4rljA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA,Ontology_term=0019171/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA chr1 CDS 595464 596585 . - . ID=CDS1;locus_tag=Rv0505c;product=Possible phosphoserine phosphatase SerB1 (PSP) (O-phosphoserine phosphohydrolase) (pspase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 596759 597202 . + . ID=CDS1;locus_tag=Rv0506;product=Probable conserved membrane protein MmpS2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 597199 600105 . + . ID=CDS1;locus_tag=Rv0507;product=Probable conserved transmembrane transport protein MmpL2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 600098 600391 . + . ID=CDS1;locus_tag=Rv0508;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 600441 601847 . + . ID=CDS1;locus_tag=Rv0509;product=Probable glutamyl-tRNA reductase HemA (GLUTR);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 601857 602786 . + . ID=CDS1;locus_tag=Rv0510;product=Probable porphobilinogen deaminase HemC (PBG) (hydroxymethylbilane synthase) (HMBS) (pre-uroporphyrinogen synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 602819 604516 . + . ID=CDS1;locus_tag=Rv0511;product=Probable uroporphyrin-III C-methyltransferase HemD (uroporphyrinogen III methylase) (urogen III methylase) (SUMT) (urogen III methylase) (UROM);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 604602 605591 . + . ID=CDS1;locus_tag=Rv0512;product=Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 605604 606152 . + . ID=CDS1;locus_tag=Rv0513;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 606149 606448 . + . ID=CDS1;locus_tag=Rv0514;product=Possible transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 606551 608062 . + . ID=CDS1;locus_tag=Rv0515;product=Conserved 13E12 repeat family protein;Experiment=DESCRIPTION:ChIP-seq [PMID: 22528497]/note:FunctionalCategory: insertion seqs and phages/note:Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 22528497] chr1 CDS 608059 608535 . - . ID=CDS1;locus_tag=Rv0516c;product=Possible anti-anti-sigma factor;note=FunctionalCategory: information pathways chr1 CDS 608746 610056 . + . ID=CDS1;locus_tag=Rv0517;product=Possible membrane acyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 610188 610883 . + . ID=CDS1;locus_tag=Rv0518;product= putative carboxylic ester hydrolase;note=FunctionalCategory: cell wall and cell processes;EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4tx1A,3kvnX,4hyqA,2vptA,1escA,3w7vA,4jggA,2q0qA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0046555/note:identified by similarity of predicted tertiary structure to PDB 3w7vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w7vA,Ontology_term=0009279/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0044010/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3w7vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w7vA,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0004064/note:identified by similarity of predicted tertiary structure to PDB 4tx1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4tx1A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4tx1A,3kvnX,1escA,3w7vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4tx1A,3kvnX,1escA,3w7vA,Ontology_term=0071973/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0009247/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 3kvnX,1escA,3w7vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,1escA,3w7vA,Ontology_term=0000272/note:identified by similarity of predicted tertiary structure to PDB 3w7vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w7vA,Ontology_term=0016788/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0071978/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0042710/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0008610/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3w7vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w7vA,Ontology_term=0048870/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX,Ontology_term=0045493/note:identified by similarity of predicted tertiary structure to PDB 3w7vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w7vA,Ontology_term=0016298/note:identified by similarity of predicted tertiary structure to PDB 3kvnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kvnX chr1 CDS 611172 612074 . - . ID=CDS1;locus_tag=Rv0519c;product= esterase/putative carboxylic ester hydrolase;note=FunctionalCategory: cell wall and cell processes;Experiment=DESCRIPTION:protein purification and characterization, enzymatic assay [PMID: 27050490];EC_number=3.1.-.-,EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4rotA,4wy8A,3ls2A,3i6yA,5cxuA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0030600/note:identified by similarity of predicted tertiary structure to PDB 5cxuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5cxuA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4wy8A,3ls2A,3i6yA,5cxuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wy8A,3ls2A,3i6yA,5cxuA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 4wy8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wy8A,Ontology_term=0018738/note:identified by similarity of predicted tertiary structure to PDB 3ls2A,3i6yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ls2A,3i6yA,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 4wy8A,3ls2A,3i6yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wy8A,3ls2A,3i6yA,Ontology_term=0046294/note:identified by similarity of predicted tertiary structure to PDB 3ls2A,3i6yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ls2A,3i6yA chr1 CDS 612255 612605 . + . ID=CDS1;locus_tag=Rv0520;product=Possible methyltransferase/methylase (fragment);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 612598 612903 . + . ID=CDS1;locus_tag=Rv0521;product=Possible methyltransferase/methylase (fragment);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 613038 614342 . + . ID=CDS1;locus_tag=Rv0522;product=Probable GABA permease GabP (4-amino butyrate transport carrier) (GAMA-aminobutyrate permease);note=FunctionalCategory: cell wall and cell processes chr1 CDS 614326 614721 . - . ID=CDS1;locus_tag=Rv0523c;product=Conserved protein/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,3h96A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,3h96A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,3h96A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,3h96A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,3h96A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,3h96A chr1 CDS 614835 616223 . + . ID=CDS1;locus_tag=Rv0524;product=Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 616223 616831 . + . ID=CDS1;locus_tag=Rv0525;product=probable protease;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Protein expression and purification, beta-casein enzymatic assay click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625];EC_number=3.4.-.-,EC_number=5.4.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1riiA,1e58A,2a6pA,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0061621/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,1fztA,Ontology_term=0016868/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA,Ontology_term=0043209/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1yjxA,Ontology_term=0004082/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0019901/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0034774/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,1fztA,4embA,Ontology_term=0046538/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,1fztA,Ontology_term=0006110/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0007585/note:identified by similarity of predicted tertiary structure to PDB 2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hhjA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA,Ontology_term=0043312/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0045730/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=1904813/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1e58A,1qhfA,1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e58A,1qhfA,1yjxA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1fztA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1qhfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,Ontology_term=0004619/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA,Ontology_term=0005741/note:identified by similarity of predicted tertiary structure to PDB 1qhfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0006096/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA,Ontology_term=0006094/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,3gp5A,1fztA,4embA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0005758/note:identified by similarity of predicted tertiary structure to PDB 1qhfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0043456/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1e58A,1qhfA,1yjxA,2hhjA,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1e58A,1qhfA,1yjxA,2hhjA,1fztA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hhjA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA chr1 CDS 616846 617496 . + . ID=CDS1;locus_tag=Rv0526;product=Possible thioredoxin protein (thiol-disulfide interchange protein);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 617493 618272 . + . ID=CDS1;locus_tag=Rv0527;product=Possible cytochrome C-type biogenesis protein CcdA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 618305 619894 . + . ID=CDS1;locus_tag=Rv0528;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, gene expressed in vivo (in mice) during infection [PMID: 26964819] chr1 CDS 619891 620865 . + . ID=CDS1;locus_tag=Rv0529;product=Possible cytochrome C-type biogenesis protein CcsA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 620907 622124 . + . ID=CDS1;locus_tag=Rv0530;product=Conserved protein/putative acid anhydride hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bejA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0007059/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA chr1 CDS 622121 622282 . - . ID=CDS1;locus_tag=Rv0530A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 622329 622646 . + . ID=CDS1;locus_tag=Rv0531;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 622793 624577 . + . ID=CDS1;locus_tag=Rv0532;gene=PE_PGRS6;product=PE-PGRS family protein PE_PGRS6;note=FunctionalCategory: PE/PPE chr1 CDS 624473 625480 . - . ID=CDS1;locus_tag=Rv0533c;product=3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III);note=FunctionalCategory: lipid metabolism chr1 CDS 625562 626440 . - . ID=CDS1;locus_tag=Rv0534c;product=1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 626457 627251 . + . ID=CDS1;locus_tag=Rv0535;product=Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 627248 628288 . + . ID=CDS1;locus_tag=Rv0536;product=Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 628298 629731 . - . ID=CDS1;locus_tag=Rv0537c;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 630040 631686 . + . ID=CDS1;locus_tag=Rv0538;product=Immunodominant protein [PMID: 19604115], Possible conserved membrane protein;Experiment=southern hybridization, recombinant protein expression, ELISA [PMID: 19604115]/inference:similar to AA sequence:BLASTp [PMID: 19604115]/note:FunctionalCategory: cell wall and cell processes/note:also known as proline-threonine repeat protein (PTRP) with repeat motifs clustered in the C-terminal region [PMID: 11349098]/note:stimulates immune response from host during infection [PMID: 19604115]/note:Very strong structural similarity to secretory component of human secretory immunoglobulin A/note:Potential host-mimicry protein/note:identified by similarity of predicted tertiary structure to PDB:3chnS/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3chnS chr1 CDS 631743 632375 . + . ID=CDS1;locus_tag=Rv0539;product=Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 632372 633034 . + . ID=CDS1;locus_tag=Rv0540;product=Conserved hypothetical protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:COG:3222 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in cell wall biogenesis [PMID: 22485162] chr1 CDS 633055 634404 . - . ID=CDS1;locus_tag=Rv0541c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes, Possible mannosyl transferase function based on conserved amino acid domain similarity to Rv1002c and clustering on the Mtb chromosome with Rv0539 (not annotated in UniProt) [PMID: 17261566] chr1 CDS 634416 635504 . - . ID=CDS1;locus_tag=Rv0542c;product=Possible O-succinylbenzoic acid--CoA ligase MenE (OSB-CoA synthetase) (O-succinylbenzoate-CoA synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 635573 635875 . - . ID=CDS1;locus_tag=Rv0543c;product=Conserved protein;Inference=profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:08636 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in membrane associated processes [PMID: 22485162] chr1 CDS 635935 636213 . - . ID=CDS1;locus_tag=Rv0544c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, down-regulated under carbon starvation [PMID: 16781800] chr1 CDS 636210 637463 . - . ID=CDS1;locus_tag=Rv0545c;product=Probable low-affinity inorganic phosphate transporter integral membrane protein PitA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 637583 637969 . - . ID=CDS1;locus_tag=Rv0546c;product=Conserved protein/putative carbon-sulfur lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.4.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0006090/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0009438/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1lqkA,3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lqkA,3vw9A,1bh5B,1qipB,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0006357/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0004462/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1lqkA,3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lqkA,3vw9A,1bh5B,1qipB,Ontology_term=0006749/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0030316/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0043066/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3vw9A,1bh5B,1qipB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vw9A,1bh5B,1qipB chr1 CDS 638032 638916 . - . ID=CDS1;locus_tag=Rv0547c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 639012 639956 . - . ID=CDS1;locus_tag=Rv0548c;product=Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 640228 640641 . - . ID=CDS1;locus_tag=Rv0549c;product=Possible toxin VapC3;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 640638 640904 . - . ID=CDS1;locus_tag=Rv0550c;product=Possible antitoxin VapB3;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 641096 642811 . - . ID=CDS1;locus_tag=Rv0551c;product=Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 642889 644493 . + . ID=CDS1;locus_tag=Rv0552;product=Conserved protein/putative endodeoxyribonuclease;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.21.-;Ontology_term=0006259/note:identified by similarity of predicted tertiary structure to PDB 3ighX,3ighX1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ighX,3ighX1,Ontology_term=0016888/note:identified by similarity of predicted tertiary structure to PDB 3ighX,3ighX1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ighX,3ighX1,Ontology_term=0016810/note:identified by similarity of predicted tertiary structure to PDB 3ighX,3ighX1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ighX,3ighX1 chr1 CDS 644499 645470 . + . ID=CDS1;locus_tag=Rv0553;product=Probable muconate cycloisomerase MenC (cis,cis-muconate lactonizing enzyme) (MLE);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 645467 646255 . + . ID=CDS1;locus_tag=Rv0554;product=Possible peroxidase BpoC (non-haem peroxidase);note=FunctionalCategory: virulence, detoxification, adaptation;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 646298 647962 . + . ID=CDS1;locus_tag=Rv0555;product=Probable bifunctional menaquinone biosynthesis protein MenD : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) + 2-oxoglutarate decarboxylase (alpha- ketoglutarate decarboxylase) (KDC);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 647959 648474 . + . ID=CDS1;locus_tag=Rv0556;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 648536 649672 . + . ID=CDS1;locus_tag=Rv0557;product=Mannosyltransferase MgtA;note=FunctionalCategory: lipid metabolism chr1 CDS 649689 650393 . + . ID=CDS1;locus_tag=Rv0558;product=Probable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone methyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 650407 650745 . - . ID=CDS1;locus_tag=Rv0559c;product=Possible conserved secreted protein;note=FunctionalCategory: cell wall and cell processes, upregulated in the presence of rifampicin in a time- and concentration-dependent exposure to the drug, potentially involved in rifampicin resistance [PMID:23182912], upregulated upon Rv2887 deletion [PMID:26303802], salicylate-induced gene [PMID:16175359], induced and exported in vivo [PMID: 28442606] chr1 CDS 650779 651504 . - . ID=CDS1;locus_tag=Rv0560c;product=Possible benzoquinone methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 651529 652755 . - . ID=CDS1;locus_tag=Rv0561c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 652771 653778 . + . ID=CDS1;locus_tag=Rv0562;product=Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 653879 654739 . + . ID=CDS1;locus_tag=Rv0563;product=Probable protease transmembrane protein heat shock protein HtpX;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 654924 655949 . - . ID=CDS1;locus_tag=Rv0564c;product=Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase);note=FunctionalCategory: lipid metabolism chr1 CDS 656010 657470 . - . ID=CDS1;locus_tag=Rv0565c;product=Probable monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 657548 658039 . - . ID=CDS1;locus_tag=Rv0566c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 658321 659340 . + . ID=CDS1;locus_tag=Rv0567;product=Probable methyltransferase/methylase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 659450 660868 . + . ID=CDS1;locus_tag=Rv0568;product=Possible cytochrome P450 135B1 Cyp135B1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 661003 661269 . + . ID=CDS1;locus_tag=Rv0569;product=Putative hypoxic signal transduction protein;Experiment=DESCRIPTION:Solution structure, Circular dichroism measurement, NMR [PMID: 24275361]/note:FunctionalCategory: conserved hypotheticals/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 661295 663373 . + . ID=CDS1;locus_tag=Rv0570;product=Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase);note=FunctionalCategory: information pathways chr1 CDS 663487 664818 . - . ID=CDS1;locus_tag=Rv0571c;product=probable serine hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals/note:possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=3.1.-.- chr1 CDS 665042 665383 . - . ID=CDS1;locus_tag=Rv0572c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 665851 667242 . - . ID=CDS1;locus_tag=Rv0573c;product=Nicotinic acid phosphoribosyltransferase PncB2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 667252 668394 . - . ID=CDS1;locus_tag=Rv0574c;product=Probable poly-glutamate synthesis accessory protein;Experiment=EXISTENCE:Southern Blot[PMID: 25312955],Experiment=DESCRIPTION:Knockout-Complementation study coupled with poly-α-l-glutamine quantification[PMID: 25312955]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in poly-α-l-glutamine biosynthesis[PMID:25312955]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 668579 669745 . - . ID=CDS1;locus_tag=Rv0575c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 669848 671152 . + . ID=CDS1;locus_tag=Rv0576;product=Probable transcriptional regulatory protein (possibly ArsR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 671166 671951 . + . ID=CDS1;locus_tag=Rv0577;gene=cfp32;product=Putative Antigen;Experiment=DESCRIPTION:recombinant protein expression, immunoprecipitation, immunoblotting, cytotoxicity analysis, flow cytometry, MLR [PMID: 22415304]/note:FunctionalCategory: conserved hypotheticals/note:Putatively interacts with Toll-like receptor 2, induces maturation of dendritic cells [PMID: 22415304]/note:Conserved protein TB27.3 [TubercuList] chr1 CDS 671996 675916 . - . ID=CDS1;locus_tag=Rv0578c;gene=PE_PGRS7;product=PE-PGRS family protein PE_PGRS7;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry[PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:located in the cell membrane [PMID: 21920479] chr1 CDS 676238 676996 . + . ID=CDS1;locus_tag=Rv0579;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 677125 677616 . - . ID=CDS1;locus_tag=Rv0580c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 677710 677925 . + . ID=CDS1;locus_tag=Rv0581;product=Possible antitoxin VapB26;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 677922 678329 . + . ID=CDS1;locus_tag=Rv0582;product=Possible toxin VapC26. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 678389 679075 . - . ID=CDS1;locus_tag=Rv0583c;product=Probable conserved lipoprotein LpqN;note=FunctionalCategory: cell wall and cell processes chr1 CDS 679229 681862 . + . ID=CDS1;locus_tag=Rv0584;product=Possible conserved exported protein/putative glycosidase;note=FunctionalCategory: cell wall and cell processes, possible alpha-mannosidase [PMID: 27697825];EC_number=3.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2xsgA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0030246/note:identified by similarity of predicted tertiary structure to PDB 2xsgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xsgA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2xsgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xsgA chr1 CDS 681885 684272 . - . ID=CDS1;locus_tag=Rv0585c;product=Probable conserved integral membrane protein/putative receptor protein;note=FunctionalCategory: cell wall and cell processes, identified by similarity of predicted tertiary structure to PDB:4c0oA,2x19B,3icqT, possible nucleic acid transport receptor protein (structural simlarity suggests potential host-mimicry), structural similarity to eukaryotic RNA transporters and primary nuclear transporters;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c0oA,2x19B,3icqT chr1 CDS 684410 685132 . + . ID=CDS1;locus_tag=Rv0586;product=Probable transcriptional regulatory protein Mce2R (GntR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 685129 685926 . + . ID=CDS1;locus_tag=Rv0587;gene=yrbE2A;product=Conserved hypothetical integral membrane protein YrbE2A;note=FunctionalCategory: virulence, detoxification, adaptation, possibly part of ABC - phospholipid transporter [PMID: 27973588] chr1 CDS 685928 686815 . + . ID=CDS1;locus_tag=Rv0588;gene=yrbE2B;product=Conserved hypothetical integral membrane protein YrbE2B;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 686821 688035 . + . ID=CDS1;locus_tag=Rv0589;product=Mce-family protein Mce2A;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 688032 688859 . + . ID=CDS1;locus_tag=Rv0590;product=Mce-family protein Mce2B;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 688808 689062 . + . ID=CDS1;locus_tag=Rv0590A;product=Mce-family related protein;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 689059 690504 . + . ID=CDS1;locus_tag=Rv0591;product=Mce-family protein Mce2C;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 690501 692027 . + . ID=CDS1;locus_tag=Rv0592;product=Mce-family protein Mce2D;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 692024 693232 . + . ID=CDS1;locus_tag=Rv0593;product=Possible Mce-family lipoprotein LprL (Mce-family lipoprotein Mce2E);note=FunctionalCategory: cell wall and cell processes chr1 CDS 693237 694787 . + . ID=CDS1;locus_tag=Rv0594;product=Mce-family protein Mce2F;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 694839 695231 . - . ID=CDS1;locus_tag=Rv0595c;product=Possible toxin VapC4;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 695228 695485 . - . ID=CDS1;locus_tag=Rv0596c;product=Possible antitoxin VapB4;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 695668 696903 . - . ID=CDS1;locus_tag=Rv0597c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 697154 697567 . - . ID=CDS1;locus_tag=Rv0598c;product=Possible toxin VapC27. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 697564 697800 . - . ID=CDS1;locus_tag=Rv0599c;product=Possible antitoxin VapB27;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 697904 698410 . - . ID=CDS1;locus_tag=Rv0600c;product=Two component sensor kinase [second part];note=FunctionalCategory: regulatory proteins chr1 CDS 698524 698994 . - . ID=CDS1;locus_tag=Rv0601c;product=Two component sensor kinase [first part];note=FunctionalCategory: regulatory proteins chr1 CDS 699038 699799 . - . ID=CDS1;locus_tag=Rv0602c;product=Two component DNA binding transcriptional regulatory protein TcrA;note=FunctionalCategory: regulatory proteins chr1 CDS 699856 700167 . + . ID=CDS1;locus_tag=Rv0603;product=Possible exported protein;note=FunctionalCategory: cell wall and cell processes, identified by similarity of predicted tertiary structure to PDB:2kgyA, structural homolog of 2kgyA, a protein of unknown function;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2kgyA chr1 CDS 700239 701189 . + . ID=CDS1;locus_tag=Rv0604;product=Probable conserved lipoprotein LpqO;note=FunctionalCategory: cell wall and cell processes chr1 CDS 701406 702014 . + . ID=CDS1;locus_tag=Rv0605;product=Possible resolvase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 702016 702759 . + . ID=CDS1;locus_tag=Rv0606;product=Possible transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 702813 703199 . + . ID=CDS1;locus_tag=Rv0607;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 703244 703489 . + . ID=CDS1;locus_tag=Rv0608;product=Possible antitoxin VapB28;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 703486 703887 . + . ID=CDS1;locus_tag=Rv0609;product=Possible toxin VapC28. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 703830 704057 . + . ID=CDS1;locus_tag=Rv0609A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 704752 705909 . - . ID=CDS1;locus_tag=Rv0610c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 705961 706344 . - . ID=CDS1;locus_tag=Rv0611c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 706324 706929 . + . ID=CDS1;locus_tag=Rv0612;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 706948 709515 . - . ID=CDS1;locus_tag=Rv0613c;product=probable protease/putative transport protein;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Protein expression and purification, beta-casein enzymatic assay, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:identified by similarity of predicted tertiary structure to PDB:4c0oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c0oA;EC_number=3.4.-.- chr1 CDS 709356 710348 . + . ID=CDS1;locus_tag=Rv0614;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 710345 710587 . + . ID=CDS1;locus_tag=Rv0615;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes, induced and exported in vivo [PMID: 28442606] chr1 CDS 710584 710850 . - . ID=CDS1;locus_tag=Rv0616c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 710782 711009 . + . ID=CDS1;locus_tag=Rv0616A;product=Possible antitoxin VapB29;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 711006 711407 . + . ID=CDS1;locus_tag=Rv0617;product=Possible toxin VapC29. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 711536 712231 . + . ID=CDS1;locus_tag=Rv0618;product=Probable galactose-1-phosphate uridylyltransferase GalTa [first part];note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 712174 712719 . + . ID=CDS1;locus_tag=Rv0619;product=Probable galactose-1-phosphate uridylyltransferase GalTb [second part];note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 712716 713807 . + . ID=CDS1;locus_tag=Rv0620;product=Probable galactokinase GalK (galactose kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 714202 715266 . + . ID=CDS1;locus_tag=Rv0621;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes, possibly involved in the regulation of fatty acid metabolism [PMID: 18979228], involved in surfactant tolerance, overexpression correlated with SDS resistance [PMID: 18979228] chr1 CDS 715370 716317 . + . ID=CDS1;locus_tag=Rv0622;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 716410 716664 . + . ID=CDS1;locus_tag=Rv0623;product=Possible antitoxin VapB30;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 716664 717059 . + . ID=CDS1;locus_tag=Rv0624;product=Possible toxin VapC30. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 717153 717893 . - . ID=CDS1;locus_tag=Rv0625c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 718025 718285 . + . ID=CDS1;locus_tag=Rv0626;product=Possible antitoxin VapB5;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 718282 718689 . + . ID=CDS1;locus_tag=Rv0627;product=Possible toxin VapC5;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 718761 719912 . - . ID=CDS1;locus_tag=Rv0628c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 720005 721732 . - . ID=CDS1;locus_tag=Rv0629c;product=Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide);note=FunctionalCategory: information pathways chr1 CDS 721729 725013 . - . ID=CDS1;locus_tag=Rv0630c;product=Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease);note=FunctionalCategory: information pathways chr1 CDS 725013 728306 . - . ID=CDS1;locus_tag=Rv0631c;product=Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide);note=FunctionalCategory: information pathways chr1 CDS 728583 729278 . - . ID=CDS1;locus_tag=Rv0632c;product=Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 729327 730166 . - . ID=CDS1;locus_tag=Rv0633c;product=Possible exported protein;note=FunctionalCategory: cell wall and cell processes, necessary in chronic phase of infection [PMID: 26270051] chr1 CDS 730320 731033 . - . ID=CDS1;locus_tag=Rv0634c;product=Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 731113 731364 . + . ID=CDS1;locus_tag=Rv0634A;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 731712 731879 . + . ID=CDS1;locus_tag=Rv0634B;product=50S ribosomal protein L33 RpmG2;note=FunctionalCategory: information pathways chr1 CDS 731930 732406 . + . ID=CDS1;locus_tag=Rv0635;product=(3R)-hydroxyacyl-ACP dehydratase subunit HadA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 732393 732821 . + . ID=CDS1;locus_tag=Rv0636;product=(3R)-hydroxyacyl-ACP dehydratase subunit HadB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 732825 733325 . + . ID=CDS1;locus_tag=Rv0637;product=(3R)-hydroxyacyl-ACP dehydratase subunit HadC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 733737 734222 . + . ID=CDS1;locus_tag=Rv0638;product=Probable preprotein translocase SecE1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 734254 734970 . + . ID=CDS1;locus_tag=Rv0639;product=Probable transcription antitermination protein NusG;note=FunctionalCategory: information pathways chr1 CDS 735022 735450 . + . ID=CDS1;locus_tag=Rv0640;product=50S ribosomal protein L11 RplK;note=FunctionalCategory: information pathways chr1 CDS 735517 736224 . + . ID=CDS1;locus_tag=Rv0641;product=50S ribosomal protein L1 RplA;note=FunctionalCategory: information pathways chr1 CDS 736298 737203 . - . ID=CDS1;locus_tag=Rv0642c;product=Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 737268 738149 . - . ID=CDS1;locus_tag=Rv0643c;product=Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 738297 739160 . - . ID=CDS1;locus_tag=Rv0644c;product=Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 739327 740187 . - . ID=CDS1;locus_tag=Rv0645c;product=Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 740234 741139 . - . ID=CDS1;locus_tag=Rv0646c;product=Probable lipase/esterase LipG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 741151 742617 . - . ID=CDS1;locus_tag=Rv0647c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 742719 746366 . + . ID=CDS1;locus_tag=Rv0648;product=Alpha-mannosidase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 746363 747037 . + . ID=CDS1;locus_tag=Rv0649;product=Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT);note=FunctionalCategory: lipid metabolism chr1 CDS 747037 747945 . + . ID=CDS1;locus_tag=Rv0650;product=Possible sugar kinase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 748276 748812 . + . ID=CDS1;locus_tag=Rv0651;product=50S ribosomal protein L10 RplJ;note=FunctionalCategory: information pathways chr1 CDS 748849 749241 . + . ID=CDS1;locus_tag=Rv0652;product=50S ribosomal protein L7/L12 RplL (SA1);note=FunctionalCategory: information pathways chr1 CDS 749234 749929 . - . ID=CDS1;locus_tag=Rv0653c;product=Possible transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 750000 751505 . + . ID=CDS1;locus_tag=Rv0654;product=Probable dioxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 751517 752596 . + . ID=CDS1;locus_tag=Rv0655;product=Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl;note=FunctionalCategory: cell wall and cell processes chr1 CDS 752984 753367 . - . ID=CDS1;locus_tag=Rv0656c;product=Possible toxin VapC6;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 753462 753617 . - . ID=CDS1;locus_tag=Rv0657c;product=Possible antitoxin VapB6;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 753693 754409 . - . ID=CDS1;locus_tag=Rv0658c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 754685 754993 . - . ID=CDS1;locus_tag=Rv0659c;product=Toxin MazF2;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 754980 755225 . - . ID=CDS1;locus_tag=Rv0660c;product=Possible antitoxin MazE2;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 755335 755772 . - . ID=CDS1;locus_tag=Rv0661c;product=Possible toxin VapC7;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 755769 756023 . - . ID=CDS1;locus_tag=Rv0662c;product=Possible antitoxin VapB7;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 756137 758500 . + . ID=CDS1;locus_tag=Rv0663;product=Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 758532 758804 . + . ID=CDS1;locus_tag=Rv0664;product=Possible antitoxin VapB8;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 758801 759139 . + . ID=CDS1;locus_tag=Rv0665;product=Possible toxin VapC8;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 759136 759309 . + . ID=CDS1;locus_tag=Rv0666;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes, upregulated in stationary phase and during chronic infection in mice [PMID: 24516549], significantly down-regulated in vitro C model of dormancy [PMID: 25645949] chr1 CDS 759807 763325 . + . ID=CDS1;locus_tag=Rv0667;product=DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit);note=FunctionalCategory: information pathways chr1 CDS 763370 767320 . + . ID=CDS1;locus_tag=Rv0668;product=DNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit).;note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 767684 769597 . - . ID=CDS1;locus_tag=Rv0669c;product=Possible hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 769792 770550 . + . ID=CDS1;locus_tag=Rv0670;product=Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase);note=FunctionalCategory: information pathways chr1 CDS 770582 771424 . + . ID=CDS1;locus_tag=Rv0671;product=Possible conserved lipoprotein LpqP;note=FunctionalCategory: cell wall and cell processes chr1 CDS 771484 773112 . + . ID=CDS1;locus_tag=Rv0672;product=Probable acyl-CoA dehydrogenase FadE8;note=FunctionalCategory: lipid metabolism chr1 CDS 773123 774061 . + . ID=CDS1;locus_tag=Rv0673;product=Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 774064 774786 . + . ID=CDS1;locus_tag=Rv0674;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, potential transcriptional regulator, identified by similarity of predicted tertiary structure to PDB:3l09C;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l09C chr1 CDS 774783 775574 . + . ID=CDS1;locus_tag=Rv0675;product=Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 775586 778480 . - . ID=CDS1;locus_tag=Rv0676c;product=Probable conserved transmembrane transport protein MmpL5;note=FunctionalCategory: cell wall and cell processes chr1 CDS 778477 778905 . - . ID=CDS1;locus_tag=Rv0677c;product=Possible conserved membrane protein MmpS5;note=FunctionalCategory: cell wall and cell processes chr1 CDS 778990 779487 . + . ID=CDS1;locus_tag=Rv0678;gene=mmpR5;product=MarR-like transcriptional regulator;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Protein expression and purification, crystallization, electrophoretic mobility shift assay (EMSA) DNase I Footprint Assay [PMID: 24737322]/note:Encodes a transcriptional regulator which has been implicated in acquired resistance to drugs that include azoles, bedaquiline, and clofazimine, through up-regulation of the multisubstrate efflux pump, MmpL5 [PMID: 27726334]/note:involved in the development of cross-resistance to bedaquiline in clofazimine resistant Mtb isolates [PMID: 24590481] chr1 CDS 779543 780040 . - . ID=CDS1;locus_tag=Rv0679c;product=Antigen;Experiment=ELISA [PMID: 28506215]/inference:profile:STRING database (protein-protein interactions)[PMID: 22485162]/inference:similar to AA sequence:NOG:040849 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in membrane associated processes [PMID: 22485162]/note:Conserved threonine rich protein [TubercuList]/note:Possible membrane lipoprotein located at the bacterial outer surface that may be involved in the entry of MTB into host cells. [PMID: 28182078]/note:Binds to Toll like receptors TLR2 and TLR4. [PMID: 28246463] chr1 CDS 780042 780416 . - . ID=CDS1;locus_tag=Rv0680c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 780721 781311 . + . ID=CDS1;locus_tag=Rv0681;product=Probable transcriptional regulatory protein (possibly TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 781560 781934 . + . ID=CDS1;locus_tag=Rv0682;product=30S ribosomal protein S12 RpsL;note=FunctionalCategory: information pathways chr1 CDS 781934 782404 . + . ID=CDS1;locus_tag=Rv0683;product=30S ribosomal protein S7 RpsG;note=FunctionalCategory: information pathways chr1 CDS 782485 784590 . + . ID=CDS1;locus_tag=Rv0684;product=Probable elongation factor G FusA1 (EF-G);note=FunctionalCategory: information pathways chr1 CDS 784821 786011 . + . ID=CDS1;locus_tag=Rv0685;product=Probable iron-regulated elongation factor TU Tuf (EF-TU);note=FunctionalCategory: information pathways chr1 CDS 786149 786946 . + . ID=CDS1;locus_tag=Rv0686;product=T-cell antigen [PMID: 17922044];note=FunctionalCategory: cell wall and cell processes, CFP-10 (T-cell antigenic target, essential for virulence) interacts with Rv0686 [PMID: 17922044], member of the signal-recognition pathway (SRP)-GTPase family (possibly involved in targeting of CFP-10 to the membrane by SRP) [PMID: 16844784] chr1 CDS 787099 787926 . + . ID=CDS1;locus_tag=Rv0687;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 787940 789160 . + . ID=CDS1;locus_tag=Rv0688;product=Putative ferredoxin reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 789157 789411 . - . ID=CDS1;locus_tag=Rv0689c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 790024 791073 . - . ID=CDS1;locus_tag=Rv0690c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 791070 791666 . - . ID=CDS1;locus_tag=Rv0691c;product=Probable transcriptional regulatory protein/probable transcriptional regulator;note=FunctionalCategory: regulatory proteins, TetR family regulator [PMID: 10565547] [PMID: 21223593], Regulates 4 anti-sigma factors [PMID: 27029515];Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2raeA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2raeA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2raeA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2raeA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2raeA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2raeA chr1 CDS 791658 791846 . + . ID=CDS1;locus_tag=Rv0691A;product=Mycofactocin precursor protein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 791831 792160 . + . ID=CDS1;locus_tag=Rv0692;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 792157 793332 . + . ID=CDS1;locus_tag=Rv0693;product=Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 793335 794525 . + . ID=CDS1;locus_tag=Rv0694;product=Possible L-lactate dehydrogenase (cytochrome) LldD1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 794715 795470 . + . ID=CDS1;locus_tag=Rv0695;product=putative creatininase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.2.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1q3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q3kA,Ontology_term=0006602/note:identified by similarity of predicted tertiary structure to PDB 1q3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q3kA,Ontology_term=0006601/note:identified by similarity of predicted tertiary structure to PDB 1q3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q3kA,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 1q3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q3kA,Ontology_term=0047789/note:identified by similarity of predicted tertiary structure to PDB 1q3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q3kA,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1q3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q3kA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1q3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q3kA chr1 CDS 795519 796931 . + . ID=CDS1;locus_tag=Rv0696;product=Probable membrane sugar transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 796933 798372 . + . ID=CDS1;locus_tag=Rv0697;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 798833 799444 . + . ID=CDS1;locus_tag=Rv0698;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 799629 799850 . + . ID=CDS1;locus_tag=Rv0699;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 800487 800792 . + . ID=CDS1;locus_tag=Rv0700;product=30S ribosomal protein S10 RpsJ (transcription antitermination factor NusE);note=FunctionalCategory: information pathways chr1 CDS 800809 801462 . + . ID=CDS1;locus_tag=Rv0701;product=50S ribosomal protein L3 RplC;note=FunctionalCategory: information pathways chr1 CDS 801459 802133 . + . ID=CDS1;locus_tag=Rv0702;product=50S ribosomal protein L4 RplD;note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 802133 802435 . + . ID=CDS1;locus_tag=Rv0703;product=50S ribosomal protein L23 RplW;note=FunctionalCategory: information pathways chr1 CDS 802528 803370 . + . ID=CDS1;locus_tag=Rv0704;product=50S ribosomal protein L2 RplB;note=FunctionalCategory: information pathways chr1 CDS 803411 803692 . + . ID=CDS1;locus_tag=Rv0705;product=30S ribosomal protein S19 RpsS;note=FunctionalCategory: information pathways chr1 CDS 803689 804282 . + . ID=CDS1;locus_tag=Rv0706;product=50S ribosomal protein L22 RplV;note=FunctionalCategory: information pathways chr1 CDS 804282 805106 . + . ID=CDS1;locus_tag=Rv0707;product=30S ribosomal protein S3 RpsC;note=FunctionalCategory: information pathways chr1 CDS 805110 805526 . + . ID=CDS1;locus_tag=Rv0708;product=50S ribosomal protein L16 RplP;note=FunctionalCategory: information pathways chr1 CDS 805526 805759 . + . ID=CDS1;locus_tag=Rv0709;product=50S ribosomal protein L29 RpmC;note=FunctionalCategory: information pathways chr1 CDS 805756 806166 . + . ID=CDS1;locus_tag=Rv0710;product=30S ribosomal protein S17 RpsQ;note=FunctionalCategory: information pathways chr1 CDS 806335 808698 . + . ID=CDS1;locus_tag=Rv0711;product=Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 808746 809645 . + . ID=CDS1;locus_tag=Rv0712;product=Formylglycine-generating enzyme;Experiment=gene knockout and complementation, quantitative mass spectrometry, transposon mutagenesis [PMID: 28505176],Experiment=DESCRIPTION:Site-directed mutagenesis, Protein expression and purification, FGE activity assay and structure determination [PMID: 18390551]/note:FunctionalCategory: conserved hypotheticals/note:required for Type I sulfatase activation [PMID: 18390551]/note:essential for macrophage type I interferon response to infection [PMID: 28505176]/note:required for phthiocerol dimycocerosate production [PMID: 28505176] chr1 CDS 809946 810887 . + . ID=CDS1;locus_tag=Rv0713;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, induced and exported in vivo [PMID: 28442606] chr1 CDS 811373 811741 . + . ID=CDS1;locus_tag=Rv0714;product=50S ribosomal protein L14 RplN;note=FunctionalCategory: information pathways chr1 CDS 811742 812059 . + . ID=CDS1;locus_tag=Rv0715;product=50S ribosomal protein L24 RplX;note=FunctionalCategory: information pathways chr1 CDS 812059 812622 . + . ID=CDS1;locus_tag=Rv0716;product=50S ribosomal protein L5 RplE;note=FunctionalCategory: information pathways chr1 CDS 812627 812812 . + . ID=CDS1;locus_tag=Rv0717;product=30S ribosomal protein S14 RpsN1;note=FunctionalCategory: information pathways chr1 CDS 812976 813374 . + . ID=CDS1;locus_tag=Rv0718;product=30S ribosomal protein S8 RpsH;note=FunctionalCategory: information pathways chr1 CDS 813398 813937 . + . ID=CDS1;locus_tag=Rv0719;product=50S ribosomal protein L6 RplF;note=FunctionalCategory: information pathways chr1 CDS 813940 814308 . + . ID=CDS1;locus_tag=Rv0720;product=50S ribosomal protein L18 RplR;note=FunctionalCategory: information pathways chr1 CDS 814328 814990 . + . ID=CDS1;locus_tag=Rv0721;product=30S ribosomal protein S5 RpsE;note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 814993 815190 . + . ID=CDS1;locus_tag=Rv0722;product=50S ribosomal protein L30 RpmD;note=FunctionalCategory: information pathways chr1 CDS 815190 815630 . + . ID=CDS1;locus_tag=Rv0723;product=50S ribosomal protein L15 RplO;note=FunctionalCategory: information pathways chr1 CDS 815663 817534 . + . ID=CDS1;locus_tag=Rv0724;product=Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 817531 817866 . - . ID=CDS1;locus_tag=Rv0724A;product=probable methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:2ckdA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA chr1 CDS 817539 818444 . - . ID=CDS1;locus_tag=Rv0725c;product=probable methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA chr1 CDS 818537 819640 . - . ID=CDS1;locus_tag=Rv0726c;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 819843 820499 . - . ID=CDS1;locus_tag=Rv0727c;product=Possible L-fuculose phosphate aldolase FucA (L-fuculose-1-phosphate aldolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 820496 821476 . - . ID=CDS1;locus_tag=Rv0728c;product=Possible D-3-phosphoglycerate dehydrogenase SerA2 (phosphoglycerate dehydrogenase) (PGDH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 821507 822853 . + . ID=CDS1;locus_tag=Rv0729;product=Possible D-xylulose kinase XylB (xylulokinase) (xylulose kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 822866 823594 . + . ID=CDS1;locus_tag=Rv0730;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 823683 824639 . - . ID=CDS1;locus_tag=Rv0731c;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 824800 826125 . + . ID=CDS1;locus_tag=Rv0732;product=Probable preprotein translocase SecY;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 826122 826667 . + . ID=CDS1;locus_tag=Rv0733;product=Adenylate kinase Adk (ATP-AMP transphosphorylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 826670 827470 . + . ID=CDS1;locus_tag=Rv0734;product=Methionine aminopeptidase MapA (map) (peptidase M) (MetAP);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 827543 828076 . + . ID=CDS1;locus_tag=Rv0735;product=Probable alternative RNA polymerase sigma factor SigL;note=FunctionalCategory: information pathways chr1 CDS 828140 828892 . + . ID=CDS1;locus_tag=Rv0736;product=Anti-sigma factor RslA;note=FunctionalCategory: information pathways chr1 CDS 829207 829704 . + . ID=CDS1;locus_tag=Rv0737;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins, MarR family transcriptional regulator [PMID: 27432954], Possibly involved in regulation of latency/dormancy [PMID: 23146828];Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 4b8xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4b8xA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 4b8xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4b8xA chr1 CDS 830062 830610 . + . ID=CDS1;locus_tag=Rv0738;product=Conserved protein/putative thiol-dependent DinB-like metalloenzyme;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:identified by similarity of predicted tertiary structure to PDB:2nsgA,2nsfA/inference:ab initio prediction:I-TASSER:5.1/note:Shares the four-helix up-down-down-up bundle, salt-bridge domain-linking residues, metal-coordinating histidine triad, and predicted metal-binding site characteristic of DinB family metalloenzymes/note:Has the thiol-interacting Trp and Arg residues of the catalytic center conserved/note:potential mycothiol-dependent S-transferase” (EC 2.-.-.-);Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2nsgA,2nsfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsgA,2nsfA chr1 CDS 830855 831661 . + . ID=CDS1;locus_tag=Rv0739;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 831776 832303 . + . ID=CDS1;locus_tag=Rv0740;product=Conserved hypothetical protein;Experiment=DESCRIPTION:exosome isolation, gene expression studies, SYTO RNASelect staining of exosomes, in vivo translation [PMID: 25753779]/note:FunctionalCategory: conserved hypotheticals/note:This protein was identified to be present in the exosome of Mycobacterium tuberculosis infected macrophages[PMID: 25753779] chr1 CDS 832534 832848 . + . ID=CDS1;locus_tag=Rv0741;product=Probable transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 832981 833508 . + . ID=CDS1;locus_tag=Rv0742;gene=PE_PGRS8;product=PE-PGRS family protein PE_PGRS8;note=FunctionalCategory: PE/PPE chr1 CDS 833886 834443 . - . ID=CDS1;locus_tag=Rv0743c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 834440 834946 . - . ID=CDS1;locus_tag=Rv0744c;product=Possible transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins, Upregulated in hypoxia and down-regulated in dosS mutant strains [PMID: 26270051] chr1 CDS 835154 835681 . + . ID=CDS1;locus_tag=Rv0745;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 835701 838052 . + . ID=CDS1;locus_tag=Rv0746;gene=PE_PGRS9;product=PE-PGRS family protein PE_PGRS9;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 838451 840856 . + . ID=CDS1;locus_tag=Rv0747;gene=PE_PGRS10;product=PE-PGRS family protein PE_PGRS10;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 840947 841204 . + . ID=CDS1;locus_tag=Rv0748;product=Possible antitoxin VapB31;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 841228 841656 . + . ID=CDS1;locus_tag=Rv0749;product=Possible toxin VapC31. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 841737 841874 . - . ID=CDS1;locus_tag=Rv0749A;product=Hypothetical protein (fragment);note=FunctionalCategory: conserved hypotheticals chr1 CDS 842033 842278 . + . ID=CDS1;locus_tag=Rv0750;product=Conserved hypothetical protein;Experiment=DESCRIPTION:qRT-PCR, microarray analysis, gene knockouts [PMID: 21401735]/note:FunctionalCategory: conserved hypotheticals/note:Potentially regulated (repressed) by acid and phagosome regulated protein A (aprA)[PMID: 21401735]. chr1 CDS 842347 843231 . - . ID=CDS1;locus_tag=Rv0751c;product=Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 843242 844414 . - . ID=CDS1;locus_tag=Rv0752c;product=Probable acyl-CoA dehydrogenase FadE9;note=FunctionalCategory: lipid metabolism chr1 CDS 844421 845953 . - . ID=CDS1;locus_tag=Rv0753c;product=Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 846159 847913 . + . ID=CDS1;locus_tag=Rv0754;gene=PE_PGRS11;product=Immunodominant antigen | phosphoglycerate mutase;Experiment=DESCRIPTION: Protein expression and purification, generate polyclonal antibodies, enzymatic activity assay. [PMID: 20558725],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Hypoxia-responsive gene. [PMID: 20558725]/note:encodes a functional phosphoglycerate mutase. [PMID: 20558725]/note:Regulates resistance to oxidative stress in Mycobacterium tuberculosis by triggering TLR2-dependent expression of COX-2 and Bcl2. [PMID: 20558725]/note:Induces maturation and activation of human dendrite cells. [PMID: 20176745]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642];EC_number=5.4.2.12 chr1 CDS 848103 850040 . - . ID=CDS1;locus_tag=Rv0755c;gene=PPE12;product=PPE family protein PPE12;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 850342 850527 . - . ID=CDS1;locus_tag=Rv0755A;product=Putative transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 850741 851466 . - . ID=CDS1;locus_tag=Rv0756c;product=Unknown protein;Experiment=DESCRIPTION:ChIP-seq [PMID: 24874799],Experiment=DESCRIPTION:ELISA for TNF expression [PMID: 27247233]/note:FunctionalCategory: conserved hypotheticals/note:Putatively contains PhoP binding site [PMID: 24874799]/note:Putatively down-regulates TNF-alpha [PMID: 27247233] chr1 CDS 851629 852351 . + . ID=CDS1;locus_tag=Rv0757;product=Possible two component system response transcriptional positive regulator PhoP;note=FunctionalCategory: regulatory proteins;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 852396 853853 . + . ID=CDS1;locus_tag=Rv0758;product=Possible two component system response sensor kinase membrane associated PhoR;note=FunctionalCategory: regulatory proteins chr1 CDS 853825 854157 . - . ID=CDS1;locus_tag=Rv0759c;product=putative acid anhydride phosphatase/putative nucleotidyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2fitA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.7.7.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0047710/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0033499/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0008108/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0005794/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0019388/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0003877/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0072332/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0004335/note:identified by similarity of predicted tertiary structure to PDB 1guqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0032435/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2fitA,3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,3anoA,Ontology_term=0046835/note:identified by similarity of predicted tertiary structure to PDB 1guqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,Ontology_term=0006012/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,1guqA,5in3B,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0006915/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0015967/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0001650/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2fitA,3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,3anoA,1guqA,5in3B,Ontology_term=0009117/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2fitA,3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,3anoA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0006011/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0008198/note:identified by similarity of predicted tertiary structure to PDB 1guqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,1guqA,5in3B,Ontology_term=0031625/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0008796/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0006163/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2fitA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2fitA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,5in3B,Ontology_term=0006258/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2fitA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fitA,1guqA,5in3B chr1 CDS 854267 854686 . - . ID=CDS1;locus_tag=Rv0760c;product=Conserved protein/putative intramolecular isomerase/putative ether hydrolase;Experiment=robotic crystal screening, co-crystallization [PMID: 18589008]/inference:alignment: Multiple sequence alignment using ClustalW [PMID: 18589008]/note:FunctionalCategory: conserved hypotheticals/note:Potentially involved in steroid metabolism [PMID: 18589008]/note:Structural homolog of ketosteroid isomerase (KSI), but study argues that it is not likely for the gene product to be a functional KSI [PMID: 18589008],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=5.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3rgaA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.3.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bngC,1nu3B,5aifA,5aihA/inference:ab initio prediction:I-TASSER:5.1,EC_number=5.3.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1e3vB,1iskA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 3rgaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rgaA,Ontology_term=0004301/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0018744/note:identified by similarity of predicted tertiary structure to PDB 1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nu3B,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bngC,1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,1nu3B,Ontology_term=0033963/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 1e3vB,1iskA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e3vB,1iskA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0008202/note:identified by similarity of predicted tertiary structure to PDB 1e3vB,1iskA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e3vB,1iskA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 3rgaA,1e3vB,1iskA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rgaA,1e3vB,1iskA,Ontology_term=0097176/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0004769/note:identified by similarity of predicted tertiary structure to PDB 1e3vB,1iskA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e3vB,1iskA chr1 CDS 854699 855826 . - . ID=CDS1;locus_tag=Rv0761c;product=Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 855925 856470 . - . ID=CDS1;locus_tag=Rv0762c;product=Conserved hypothetical protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:44212 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in intracellular transport [PMID: 22485162]/note:Possibly interferes with the production of tyrosine kinase [PMID: 27803888]/note:Possible interaction with host ubiquitin protein (UBC) and EGFR [PMID: 27803888]/note:Possibly interferes with the type 1-alpha regulatory subunit (RI-alpha) of cAMP-dependent protein kinase (PRKAR1A) [PMID: 27803888]/note:Possible role in fatty acid metabolism and influencing the host gene RPS10 which is involved in cellular metabolic processes via interaction with UBC and ETS1 in macrophages [PMID: 27803888] chr1 CDS 856473 856679 . - . ID=CDS1;locus_tag=Rv0763c;product=Possible ferredoxin;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 856682 858037 . - . ID=CDS1;locus_tag=Rv0764c;product=Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 858037 858864 . - . ID=CDS1;locus_tag=Rv0765c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 858864 860072 . - . ID=CDS1;locus_tag=Rv0766c;product=Probable cytochrome P450 123 Cyp123;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 860069 860710 . - . ID=CDS1;locus_tag=Rv0767c;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3mnlA,3bjbB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,3bjbB,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 3mnlA,3bjbB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,3bjbB,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3mnlA,3bjbB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,3bjbB,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA chr1 CDS 860912 862381 . + . ID=CDS1;locus_tag=Rv0768;product=Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 862412 863158 . + . ID=CDS1;locus_tag=Rv0769;product=Probable dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 863256 864143 . + . ID=CDS1;locus_tag=Rv0770;product=Probable dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 864140 864574 . + . ID=CDS1;locus_tag=Rv0771;product=Possible 4-carboxymuconolactone decarboxylase (CMD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 864586 865854 . + . ID=CDS1;locus_tag=Rv0772;product=Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) (5'-phosphoribosylglycinamide synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 865851 867389 . - . ID=CDS1;locus_tag=Rv0773c;product=Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 867440 868351 . - . ID=CDS1;locus_tag=Rv0774c;product=esterase;Experiment=DESCRIPTION:Protein expression and purification, enzymatic assay, site mutagenesis assay. [PMID: 28161108],Experiment=DESCRIPTION:Protein purification and characterization, enzymatic activity assay [PMID: 27050490],Experiment=DESCTIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography mass Spectrometry [PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: cell wall and cell processes/note:modulate the pro-inflammatory immune response to support intracellular survival. [PMID: 28161108]/note:hydrolyzes short and mid chain esters and short chain lipid but not long chain triolein lipid. [PMID: 28161108];EC_number=3.1.1.-,EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4rotA,3ls2A,3i6yA,5cxuA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0030600/note:identified by similarity of predicted tertiary structure to PDB 5cxuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5cxuA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3ls2A,3i6yA,5cxuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ls2A,3i6yA,5cxuA,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 3ls2A,3i6yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ls2A,3i6yA,Ontology_term=0046294/note:identified by similarity of predicted tertiary structure to PDB 3ls2A,3i6yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ls2A,3i6yA,Ontology_term=0018738/note:identified by similarity of predicted tertiary structure to PDB 3ls2A,3i6yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ls2A,3i6yA chr1 CDS 868407 869030 . + . ID=CDS1;locus_tag=Rv0775;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3iuvA,2dg8B,3kkdC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iuvA,2dg8B,3kkdC,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2dg8B,3kkdC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dg8B,3kkdC,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,3iuvA,2dg8B,3kkdC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,3iuvA,2dg8B,3kkdC,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 2dg8B,3kkdC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dg8B,3kkdC,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,3iuvA,2dg8B,3kkdC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,3iuvA,2dg8B,3kkdC,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,3iuvA,2dg8B,3kkdC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,3iuvA,2dg8B,3kkdC chr1 CDS 868984 869763 . - . ID=CDS1;locus_tag=Rv0776c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 870008 871426 . + . ID=CDS1;locus_tag=Rv0777;product=Probable adenylosuccinate lyase PurB (adenylosuccinase) (ASL) (ASASE);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 871431 872675 . + . ID=CDS1;locus_tag=Rv0778;product=Possible cytochrome P450 126 Cyp126;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 872672 873292 . - . ID=CDS1;locus_tag=Rv0779c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 873343 874236 . + . ID=CDS1;locus_tag=Rv0780;product=Phosphoribosylaminoimidazole- succinocarboxamide synthase PurC (SAICAR synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 874233 874943 . + . ID=CDS1;locus_tag=Rv0781;product=Probable protease II PtrBa [first part] (oligopeptidase B);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 874732 876390 . + . ID=CDS1;locus_tag=Rv0782;product=Probable protease II PtrBb [second part] (oligopeptidase B);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 876818 878440 . - . ID=CDS1;locus_tag=Rv0783c;product=Possible multidrug resistance integral membrane efflux protein EmrB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 878638 879324 . + . ID=CDS1;locus_tag=Rv0784;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 879340 881040 . + . ID=CDS1;locus_tag=Rv0785;product=Conserved protein/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.3.99.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4at0A,1qo8A,4c3xA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0047571/note:identified by similarity of predicted tertiary structure to PDB 4c3xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c3xA,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 1qo8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo8A,Ontology_term=0000104/note:identified by similarity of predicted tertiary structure to PDB 1qo8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo8A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4at0A,1qo8A,4c3xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4at0A,1qo8A,4c3xA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 4at0A,4c3xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4at0A,4c3xA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1qo8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo8A,Ontology_term=0102040/note:identified by similarity of predicted tertiary structure to PDB 1qo8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo8A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4at0A,1qo8A,4c3xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4at0A,1qo8A,4c3xA chr1 CDS 881075 881464 . - . ID=CDS1;locus_tag=Rv0786c;product= putative phosphoric diester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.4.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3g1pB,4qn9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0043227/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0001523/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0009395/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0042622/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0008081/note:identified by similarity of predicted tertiary structure to PDB 3g1pB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1pB,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0102200/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3g1pB,4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1pB,4qn9A,Ontology_term=0019700/note:identified by similarity of predicted tertiary structure to PDB 3g1pB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1pB,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3g1pB,4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1pB,4qn9A,Ontology_term=0006644/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 3g1pB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1pB,Ontology_term=0004620/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0103043/note:identified by similarity of predicted tertiary structure to PDB 3g1pB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1pB,Ontology_term=0007568/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0035900/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0070290/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=1903999/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A chr1 CDS 881459 882418 . + . ID=CDS1;locus_tag=Rv0787;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 882524 882763 . + . ID=CDS1;locus_tag=Rv0787A;product=Conserved protein/Probable Phosphoribosylformylglycinamidine synthase.;note=FunctionalCategory: conserved hypotheticals;EC_number=6.3.5.3 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1twjA,1vq3C,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1twjA,1vq3C,Ontology_term=0006189/note:identified by similarity of predicted tertiary structure to PDB 1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1twjA,1vq3C,Ontology_term=0016874/note:identified by similarity of predicted tertiary structure to PDB 1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1twjA,1vq3C,Ontology_term=0004642/note:identified by similarity of predicted tertiary structure to PDB 1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1twjA,1vq3C,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1twjA,1vq3C,Ontology_term=0006164/note:identified by similarity of predicted tertiary structure to PDB 1twjA,1vq3C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1twjA,1vq3C chr1 CDS 882760 883434 . + . ID=CDS1;locus_tag=Rv0788;product=Probable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 883451 884050 . - . ID=CDS1;locus_tag=Rv0789c;product=Hypothetical protein;Experiment=DESCRIPTION:microarray analysis, gene expression profiling [PMID: 20061478]/note:FunctionalCategory: conserved hypotheticals/note:Putatively predicted to be a SigE regulated gene[PMID: 20061478] chr1 CDS 884072 884800 . - . ID=CDS1;locus_tag=Rv0790c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 884797 885840 . - . ID=CDS1;locus_tag=Rv0791c;product=Conserved protein/putative F420-dependent oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.1.99.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1rhcA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.14.14.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3fgcD,3fgcA,1nqkA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.5.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1z69A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.1.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3c8nA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.14.13.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3sdoA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004497/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,3sdoA,Ontology_term=0006730/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0008726/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0047646/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0019386/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0008218/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016705/note:identified by similarity of predicted tertiary structure to PDB 1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0046306/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0015948/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0045454/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA,Ontology_term=0052749/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016614/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0070967/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0018537/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A chr1 CDS 885837 886646 . - . ID=CDS1;locus_tag=Rv0792c;product=Probable transcriptional regulatory protein (probably GntR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 886719 887024 . + . ID=CDS1;locus_tag=Rv0793;product=Possible monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 887137 888636 . - . ID=CDS1;locus_tag=Rv0794c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 889072 889398 . + . ID=CDS1;locus_tag=Rv0795;product=Putative transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 889347 890333 . + . ID=CDS1;locus_tag=Rv0796;product=Putative transposase for insertion sequence element IS6110;note=FunctionalCategory: insertion seqs and phages chr1 CDS 890388 891482 . + . ID=CDS1;locus_tag=Rv0797;product=Putative transposase for insertion sequence element IS1547;note=FunctionalCategory: insertion seqs and phages chr1 CDS 891472 892269 . - . ID=CDS1;locus_tag=Rv0798c;gene=enc;product=Encapsulin (Enc);Experiment=DESCRIPTION:co-purification, electron microscopy, mutant generation via allelic exchange, enzymatic activity (peroxidase, deferrocheletase, ferroxidase, aldolase) [PMID: 24855650]/note:FunctionalCategory: virulence, detoxification, adaptation/note:29 KDa antigen CFP29/note:protein assembles into 60-subunit cage and encapsulates a dye-decolorizing peroxidase (DyP), iron storage ferritin protein (BfrB), and 7,8-dihydroneopterin aldolase (FolB) via their c-terminal tails [PMID: 24855650]/note:Alternative gene name: cfp29 chr1 CDS 892266 893273 . - . ID=CDS1;locus_tag=Rv0799c;product=Heme-dependent peroxidase /Heme-dependent peroxidase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Protein purification and expression, preliminary characterization using peroxidase activity assays, enzyme kinetics assay[PMID: 24855650];EC_number=1.1.11.-,EC_number=1.11.1.19 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4gu7A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 4gu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gu7A,Ontology_term=0020037/note:identified by similarity of predicted tertiary structure to PDB 4gu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gu7A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4gu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gu7A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4gu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gu7A,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 4gu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gu7A chr1 CDS 893318 894619 . + . ID=CDS1;locus_tag=Rv0800;product=Probable aminopeptidase PepC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 894631 894978 . + . ID=CDS1;locus_tag=Rv0801;product=Putative glyoxalase;Experiment=DESCRIPTION:methygloxal survival assay, proline transport assay [PMID: 22507203]/note:FunctionalCategory: conserved hypotheticals/note:shows increased expression in MB100pruC;EC_number=for this one chr1 CDS 894972 895628 . - . ID=CDS1;locus_tag=Rv0802c;product=Possible succinyltransferase in the GCN5-related N-acetyltransferase family;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 895820 898084 . + . ID=CDS1;locus_tag=Rv0803;product=Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 898081 898710 . + . ID=CDS1;locus_tag=Rv0804;product=putative peptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4cadC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cadC chr1 CDS 898831 899787 . + . ID=CDS1;locus_tag=Rv0805;product=Class III cyclic nucleotide phosphodiesterase (cNMP PDE);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 899732 901330 . - . ID=CDS1;locus_tag=Rv0806c;product=Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 901635 902024 . + . ID=CDS1;locus_tag=Rv0807;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 902111 903694 . + . ID=CDS1;locus_tag=Rv0808;product=Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 903725 904819 . + . ID=CDS1;locus_tag=Rv0809;product=Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 904905 905087 . - . ID=CDS1;locus_tag=Rv0810c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 905234 906340 . - . ID=CDS1;locus_tag=Rv0811c;product=conserved protein/putative one-carbon transferase/putative oxidase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.5.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1pj6A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1pj6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pj6A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1pj6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pj6A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1vloA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vloA,Ontology_term=0004047/note:identified by similarity of predicted tertiary structure to PDB 1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA,Ontology_term=0008483/note:identified by similarity of predicted tertiary structure to PDB 1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA,Ontology_term=0047866/note:identified by similarity of predicted tertiary structure to PDB 1pj6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pj6A,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 1wsrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wsrA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1pj6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pj6A,Ontology_term=0006546/note:identified by similarity of predicted tertiary structure to PDB 1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vloA,1wsrA,1yx2B,1v5vA,3girA,1wopA,Ontology_term=0019464/note:identified by similarity of predicted tertiary structure to PDB 1vloA,1wsrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vloA,1wsrA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1wsrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wsrA,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 1wsrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wsrA chr1 CDS 906423 907292 . + . ID=CDS1;locus_tag=Rv0812;product=Probable amino acid aminotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 907338 908018 . - . ID=CDS1;locus_tag=Rv0813c;product=Putative fatty acid-binding protein;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:X-ray crystallography[PMID: 17172346],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 908181 908483 . - . ID=CDS1;locus_tag=Rv0814c;gene=ssec2;product=Conserved protein SseC2/putative metallocarboxypeptidases;note=FunctionalCategory: intermediary metabolism and respiration;EC_number=3.4.17.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0051384/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0030449/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0031225/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0005794/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0009653/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0030070/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0008237/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0097060/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0005615/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1uwyA,Ontology_term=0004181/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0004180/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0004185/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1uwyA,Ontology_term=0006501/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0043025/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1h8lA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1h8lA,1uwyA,Ontology_term=0030141/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0009986/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0010815/note:identified by similarity of predicted tertiary structure to PDB 2nsmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0016485/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 2nsmA,1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsmA,1uwyA,Ontology_term=0006518/note:identified by similarity of predicted tertiary structure to PDB 1uwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwyA,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 1h8lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1h8lA chr1 CDS 908485 909318 . - . ID=CDS1;locus_tag=Rv0815c;product=Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 909611 910033 . - . ID=CDS1;locus_tag=Rv0816c;product=Probable thioredoxin ThiX;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 910030 910842 . - . ID=CDS1;locus_tag=Rv0817c;product=Probable conserved exported protein;note=FunctionalCategory: cell wall and cell processes, induced and exported in vivo [PMID: 28442606] chr1 CDS 910972 911739 . + . ID=CDS1;locus_tag=Rv0818;gene=glnR;product=GlnR transcriptional regulatory protein;Experiment=DESCRIPTION: Mutagenesis, EMSA, accumulation of nitrite [PMID: 19332834]/note:FunctionalCategory: regulatory proteins/note:Activates transcription of the nirBD operon, which encodes a nitrate reductase and enables M. tuberculosis to grow on nitrates as the sole nitrogen source [PMID: 19332834] chr1 CDS 911736 912683 . + . ID=CDS1;locus_tag=Rv0819;product=GCN5-related N-acetyltransferase, MshD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 912726 913502 . + . ID=CDS1;locus_tag=Rv0820;product=Probable phosphate-transport ATP-binding protein ABC transporter PhoT;note=FunctionalCategory: cell wall and cell processes chr1 CDS 913558 914199 . - . ID=CDS1;locus_tag=Rv0821c;product=Probable phosphate-transport system transcriptional regulatory protein PhoY2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 914257 916311 . - . ID=CDS1;locus_tag=Rv0822c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 916477 917646 . - . ID=CDS1;locus_tag=Rv0823c;product=Possible transcriptional regulatory protein/putative CH-CH dehydrogenase;note=FunctionalCategory: regulatory proteins, overexpressed during manganese (Mn) deficiency [PMID: 26337157];EC_number=1.3.1.-;Ontology_term=0000049/note:identified by similarity of predicted tertiary structure to PDB 3b0pA,3w9zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b0pA,3w9zA,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 1vhnA,3w9zA,3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vhnA,3w9zA,3b0pA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3b0pA,1vhnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b0pA,1vhnA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1vhnA,3w9zA,3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vhnA,3w9zA,3b0pA,Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 1vhnA,3w9zA,3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vhnA,3w9zA,3b0pA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 3b0pA,3w9zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b0pA,3w9zA,Ontology_term=0002943/note:identified by similarity of predicted tertiary structure to PDB 1vhnA,3w9zA,3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vhnA,3w9zA,3b0pA,Ontology_term=0010181/note:identified by similarity of predicted tertiary structure to PDB 3b0pA,3w9zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b0pA,3w9zA,Ontology_term=0017150/note:identified by similarity of predicted tertiary structure to PDB 1vhnA,3w9zA,3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vhnA,3w9zA,3b0pA,Ontology_term=0102264/note:identified by similarity of predicted tertiary structure to PDB 3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b0pA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1vhnA,3w9zA,3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vhnA,3w9zA,3b0pA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1vhnA,3w9zA,3b0pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vhnA,3w9zA,3b0pA chr1 CDS 917734 918750 . - . ID=CDS1;locus_tag=Rv0824c;product=Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des);note=FunctionalCategory: lipid metabolism chr1 CDS 918912 919553 . - . ID=CDS1;locus_tag=Rv0825c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 919634 920689 . + . ID=CDS1;locus_tag=Rv0826;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 920741 921133 . - . ID=CDS1;locus_tag=Rv0827c;product=Metal sensor transcriptional regulator KmtR (ArsR-SmtB family);note=FunctionalCategory: regulatory proteins chr1 CDS 921191 921613 . - . ID=CDS1;locus_tag=Rv0828c;product=Possible deaminase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 921575 921865 . + . ID=CDS1;locus_tag=Rv0829;product=Possible transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 921970 922875 . + . ID=CDS1;locus_tag=Rv0830;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 922894 923709 . - . ID=CDS1;locus_tag=Rv0831c;product=bifunctional probable ATP-binding protein/putative T-cell antigen;Experiment=DESCRIPTION:recombinant gene expression, LC-MS/MS [PMID: 23352146],Experiment=DESCRIPTION:LC-MS/MS [PMID: 15908384]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 924951 925364 . + . ID=CDS1;locus_tag=Rv0832;gene=PE_PGRS12;product=PE-PGRS family protein PE_PGRS12;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry[PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:located in the cell membrane but absent in culture filtrate [PMID: 21920479],Experiment=ally [PMID: 21920479] chr1 CDS 925361 927610 . + . ID=CDS1;locus_tag=Rv0833;gene=PE_PGRS13;product=PE-PGRS family protein PE_PGRS13;note=FunctionalCategory: PE/PPE chr1 CDS 927837 930485 . - . ID=CDS1;locus_tag=Rv0834c;gene=PE_PGRS14;product=PE-PGRS family protein PE_PGRS14;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Induced by low pH and putatively participates in acid stress response [PMID: 12595455]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 930953 931597 . + . ID=CDS1;locus_tag=Rv0835;product=Possible lipoprotein LpqQ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 932279 932932 . - . ID=CDS1;locus_tag=Rv0836c;product=conserved protein;Experiment=DESCRIPTION:promoter activity assays, DIG-labeled EMSAs, in vitro radioactive GTP binding assay [PMID: 24465005]/note:FunctionalCategory: conserved hypotheticals\/note:Putative type IV toxin system chr1 CDS 933003 934031 . - . ID=CDS1;locus_tag=Rv0837c;product=conserved protein;Experiment=DESCRIPTION:promoter activity assays, DIG-labeled EMSAs, in vitro radioactive GTP binding assay [PMID: 24465005]/note:FunctionalCategory: conserved hypotheticals/note:Putative type IV antitoxin system chr1 CDS 934720 935490 . + . ID=CDS1;locus_tag=Rv0838;product=Probable conserved lipoprotein LpqR;note=FunctionalCategory: cell wall and cell processes chr1 CDS 935577 936389 . + . ID=CDS1;locus_tag=Rv0839;product=Antigen/putative methyltransferase/Antigen;Experiment=ELISPOT, Fc Receptor Blocking Assay, ELISA, T-Cell Depletion Assay, Human Antibodies Isotyping Assay, Mtb Proteome Binding Array [PMID: 28438994]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1p91A,3mggA,4iv0A,3g5tA,2yqzA,3ccfB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2yqzA,3ccfB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yqzA,3ccfB,Ontology_term=0070475/note:identified by similarity of predicted tertiary structure to PDB 1p91A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1p91A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 1p91A,3mggA,4iv0A,3g5tA,2yqzA,3ccfB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,3mggA,4iv0A,3g5tA,2yqzA,3ccfB,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3g5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g5tA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1p91A,3mggA,4iv0A,3g5tA,3ccfB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,3mggA,4iv0A,3g5tA,3ccfB,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 1p91A,3mggA,4iv0A,3g5tA,2yqzA,3ccfB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,3mggA,4iv0A,3g5tA,2yqzA,3ccfB,Ontology_term=0052911/note:identified by similarity of predicted tertiary structure to PDB 1p91A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 1p91A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,Ontology_term=0046547/note:identified by similarity of predicted tertiary structure to PDB 3g5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g5tA,Ontology_term=0030798/note:identified by similarity of predicted tertiary structure to PDB 3ccfB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ccfB,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1p91A,4iv0A,2yqzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,4iv0A,2yqzA,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 4iv0A,2yqzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,2yqzA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 4iv0A,2yqzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,2yqzA,Ontology_term=0008989/note:identified by similarity of predicted tertiary structure to PDB 1p91A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p91A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3g5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g5tA chr1 CDS 936457 937317 . - . ID=CDS1;locus_tag=Rv0840c;product=Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 937593 937835 . + . ID=CDS1;locus_tag=Rv0841;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 938112 939404 . + . ID=CDS1;locus_tag=Rv0842;product=Probable conserved integral membrane protein/Putative transporter;note=FunctionalCategory: cell wall and cell processes, possible efflux pump [PMID: 25690361], involved in rifampicin resistance [PMID: 25690361], Potential carbohydrate transporter, identified by similarity of predicted tertiary structure to PDB:5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA chr1 CDS 939388 940392 . + . ID=CDS1;locus_tag=Rv0843;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 940456 941106 . - . ID=CDS1;locus_tag=Rv0844c;product=Possible nitrate/nitrite response transcriptional regulatory protein NarL;note=FunctionalCategory: regulatory proteins chr1 CDS 941190 942467 . + . ID=CDS1;locus_tag=Rv0845;product=Possible two component sensor kinase;note=FunctionalCategory: regulatory proteins chr1 CDS 942680 944194 . - . ID=CDS1;locus_tag=Rv0846c;product=Probable oxidase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 944343 944735 . + . ID=CDS1;locus_tag=Rv0847;product=Probable lipoprotein LpqS;note=FunctionalCategory: cell wall and cell processes chr1 CDS 944938 946056 . + . ID=CDS1;locus_tag=Rv0848;product=Possible cysteine synthase a CysK2 (O-acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSASE);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 946056 947315 . + . ID=CDS1;locus_tag=Rv0849;product=Probable efflux pump/antigen/Putative transporter;Experiment=DESCRIPTION:single-crossover and double-crossover recombinants, PCR. gene knockout, resazurin-based microplate assay, drug susceptibility assays, efflux pump hyper-expression studies [PMID: 22314527]/note:FunctionalCategory: cell wall and cell processes/note:involved in resistance to compounds belonging to the Pyrrole class [PMID: 22314527]/note:putatively involved in resistance to RIF [PMID: 25695504]/note:involved in INH resistance [PMID: 25695504]/note:co-transcribed with lpqS [PMID: 23562345]/note:antigenic in LTBI only [PMID: 23169589]/note:Potential carbohydrate transporter/note:identified by similarity of predicted tertiary structure to PDB:5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA chr1 CDS 947312 947644 . + . ID=CDS1;locus_tag=Rv0850;product=Putative transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 947641 948468 . - . ID=CDS1;locus_tag=Rv0851c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 948559 949395 . + . ID=CDS1;locus_tag=Rv0852;product=Possible fatty-acid-CoA ligase FadD16 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 949436 951118 . - . ID=CDS1;locus_tag=Rv0853c;product=Probable pyruvate or indole-3-pyruvate decarboxylase Pdc;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 951183 951626 . + . ID=CDS1;locus_tag=Rv0854;product=Conserved protein/putative methyltransferase;Experiment=DESCRIPTION: mass spectrometry, 2D-gel electrophoresis [PMID: 27667981]/note:FunctionalCategory: conserved hypotheticals/note:Significantly overexpressed in hypoxia in H37Rv [PMID: 27667981];EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2rezA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 951632 952711 . + . ID=CDS1;locus_tag=Rv0855;product=Probable fatty-acid-CoA racemase Far;note=FunctionalCategory: lipid metabolism chr1 CDS 952825 953229 . + . ID=CDS1;locus_tag=Rv0856;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to bind to minocycline and rifampicin[PMID: 21079673] chr1 CDS 953257 953730 . + . ID=CDS1;locus_tag=Rv0857;product=putative methyltransferase;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:40843 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putative link to polyketide cyclase/dehydratase [PMID: 22485162];EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2rezA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 953727 954920 . - . ID=CDS1;locus_tag=Rv0858c;product=Probable N-succinyldiaminopimelate aminotransferase DapC (DAP-at);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 955077 956288 . + . ID=CDS1;locus_tag=Rv0859;product=Possible acyl-CoA thiolase FadA;note=FunctionalCategory: lipid metabolism chr1 CDS 956293 958455 . + . ID=CDS1;locus_tag=Rv0860;product=Probable fatty oxidation protein FadB;note=FunctionalCategory: lipid metabolism chr1 CDS 958523 960151 . - . ID=CDS1;locus_tag=Rv0861c;product=DNA helicase Ercc3;note=FunctionalCategory: information pathways chr1 CDS 960342 962612 . - . ID=CDS1;locus_tag=Rv0862c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 962599 962880 . + . ID=CDS1;locus_tag=Rv0863;product=Conserved hypothetical protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:40843 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in DNA-associated processes [PMID: 22485162] chr1 CDS 962890 963393 . + . ID=CDS1;locus_tag=Rv0864;product=Probable molybdenum cofactor biosynthesis protein C 2 MoaC2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 963390 963872 . + . ID=CDS1;locus_tag=Rv0865;product=Probable molybdopterin biosynthesis Mog protein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 963869 964294 . + . ID=CDS1;locus_tag=Rv0866;product=Probable molybdenum cofactor biosynthesis protein E2 MoaE2 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 964312 965535 . - . ID=CDS1;locus_tag=Rv0867c;product=Possible resuscitation-promoting factor RpfA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 965983 966261 . - . ID=CDS1;locus_tag=Rv0868c;product=Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 966265 967347 . - . ID=CDS1;locus_tag=Rv0869c;product=Probable molybdenum cofactor biosynthesis protein A2 MoaA2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 967344 967733 . - . ID=CDS1;locus_tag=Rv0870c;product=Possible conserved integral membrane protein/Putative transporter;note=FunctionalCategory: cell wall and cell processes, Potential ion channel protein, Homology with several transport proteins of the same class, overlapping the same portion of each: the selectivity filer, pore, and helices, identified by similarity of predicted tertiary structure to PDB:5an8A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5an8A chr1 CDS 967898 968305 . + . ID=CDS1;locus_tag=Rv0871;gene=cspB;product=Probable cold shock-like protein B CspB;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 968424 970244 . - . ID=CDS1;locus_tag=Rv0872c;gene=PE_PGRS15;product=PE-PGRS family protein PE_PGRS15;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 970505 972457 . + . ID=CDS1;locus_tag=Rv0873;product=Probable acyl-CoA dehydrogenase FadE10;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 972546 973706 . - . ID=CDS1;locus_tag=Rv0874c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 973806 974294 . - . ID=CDS1;locus_tag=Rv0875c;product=Possible conserved exported protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 974291 975937 . - . ID=CDS1;locus_tag=Rv0876c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, possible efflux pump [PMID: 25690361], involved in rifampicin resistance [PMID: 25690361], possible H+ antiporter, major facilitator family protein [PMID: 25766777] chr1 CDS 976075 976863 . + . ID=CDS1;locus_tag=Rv0877;product=Conserved hypothetical protein;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:06304 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in cell wall processes [PMID: 22485162] chr1 CDS 976872 978203 . - . ID=CDS1;locus_tag=Rv0878c;gene=PPE13;product=PPE family protein PPE13;note=FunctionalCategory: PE/PPE chr1 CDS 978481 978756 . - . ID=CDS1;locus_tag=Rv0879c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 978934 979365 . + . ID=CDS1;locus_tag=Rv0880;product=Possible transcriptional regulatory protein (possibly MarR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 979362 980228 . + . ID=CDS1;locus_tag=Rv0881;product=Possible rRNA methyltransferase (rRNA methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 980225 980509 . + . ID=CDS1;locus_tag=Rv0882;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes, reported to be expressed in dormancy-associated conditions (nutrition starvation) [PMID: 22484107] chr1 CDS 980506 981267 . - . ID=CDS1;locus_tag=Rv0883c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 981424 982554 . - . ID=CDS1;locus_tag=Rv0884c;product=Possible phosphoserine aminotransferase SerC (PSAT);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 982762 983784 . + . ID=CDS1;locus_tag=Rv0885;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Expression of the gene product is activated by cAMP receptor protein[PMID: 21902733] chr1 CDS 983803 985530 . + . ID=CDS1;locus_tag=Rv0886;product=Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 985513 985971 . - . ID=CDS1;locus_tag=Rv0887c;product=putative transferase;note=FunctionalCategory: conserved hypotheticals, Expression of this gene is regulated by SigG[PMID: 23871545];EC_number=2.-.-.-;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2zw6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zw6A,Ontology_term=0008080/note:identified by similarity of predicted tertiary structure to PDB 2zw6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zw6A chr1 CDS 987233 988705 . + . ID=CDS1;locus_tag=Rv0888;gene=SpmT;product=Sphingomyelinase/major hemolytic factor/Probable extracellular non-specific nuclease;Experiment=DESCRIPTION: protein expression in E. coli, transformation in M. smegmatis, site-directed mutagenesis, protein purification, SDS-PAGE mass spectrometry, nuclease activity assays, spectrophotometric assays, protein kinetics, mouse lung infection [PMID: 26742696],Experiment=DESCRIPTION: subcellular fractionation, flow cytometry biotinylation, protein purification from M. smegmatis, hemolysis/note:FunctionalCategory: cell wall and cell processes [PMID: 26742696]/note:necessary for infection [PMID: 26742696]/note:novel member of a non-specific nuclease family [PMID: 26742696]/note:accounts for half of Mtb's hemolytic activity [PMID: 26036301];EC_number=3.1.4.12,EC_number=3.1.-.-/note:induced and exported in vivo [PMID: 28442606] chr1 CDS 988740 989861 . - . ID=CDS1;locus_tag=Rv0889c;product=Probable citrate synthase II CitA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 989948 992596 . - . ID=CDS1;locus_tag=Rv0890c;product=Probable transcriptional regulatory protein (probably LuxR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 992598 993455 . - . ID=CDS1;locus_tag=Rv0891c;product=Possible transcriptional regulatory protein/putative phosphorus-oxygen lyase;note=FunctionalCategory: regulatory proteins, cyclase domain present in gene product [PMID: 21199259];EC_number=4.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1y11A,3uvjA,2w01A,2wz1A,4wp3A,1yk9A,1ybtB,4yusA,1wc4A,1fx2A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0004016/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4wp3A,Ontology_term=0007165/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0035556/note:identified by similarity of predicted tertiary structure to PDB 1y11A,3uvjA,2w01A,2wz1A,4wp3A,1yk9A,1ybtB,4yusA,1wc4A,1fx2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,3uvjA,2w01A,2wz1A,4wp3A,1yk9A,1ybtB,4yusA,1wc4A,1fx2A,Ontology_term=0071949/note:identified by similarity of predicted tertiary structure to PDB 4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4yusA,Ontology_term=0030818/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4wp3A,Ontology_term=0016849/note:identified by similarity of predicted tertiary structure to PDB 1y11A,3uvjA,2w01A,2wz1A,4wp3A,1yk9A,1ybtB,4yusA,1wc4A,1fx2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,3uvjA,2w01A,2wz1A,4wp3A,1yk9A,1ybtB,4yusA,1wc4A,1fx2A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4yusA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4wp3A,Ontology_term=0006171/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4wp3A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009882/note:identified by similarity of predicted tertiary structure to PDB 4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4yusA,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0008289/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009785/note:identified by similarity of predicted tertiary structure to PDB 4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4yusA,Ontology_term=0009268/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009190/note:identified by similarity of predicted tertiary structure to PDB 1y11A,3uvjA,2w01A,2wz1A,4wp3A,1yk9A,1ybtB,4yusA,1wc4A,1fx2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,3uvjA,2w01A,2wz1A,4wp3A,1yk9A,1ybtB,4yusA,1wc4A,1fx2A,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4wp3A,4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4wp3A,4yusA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A chr1 CDS 993853 995340 . + . ID=CDS1;locus_tag=Rv0892;product=Probable monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 995318 996295 . - . ID=CDS1;locus_tag=Rv0893c;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 996524 997705 . + . ID=CDS1;locus_tag=Rv0894;product=Possible transcriptional regulatory protein (possibly LuxR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 997782 999299 . + . ID=CDS1;locus_tag=Rv0895;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 999472 1000767 . + . ID=CDS1;locus_tag=Rv0896;product=Probable citrate synthase I GltA2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1000808 1002415 . - . ID=CDS1;locus_tag=Rv0897c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1002441 1002704 . - . ID=CDS1;locus_tag=Rv0898c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1002812 1003792 . + . ID=CDS1;locus_tag=Rv0899;gene=ompATb;product=Peptidoglycan-binding protein arfA/probable membrane-anchoring protein;Experiment=DESCRIPTION:protein purification, size-exclusion chromatography, site-directed mutagenesis, Differential scanning fluorimetry, peptidoglycan binding assays, NMR spectroscopy [PMID: 22206986],Experiment=DESCRIPTION:protein expression and purification, ultracentrifugation and liposome reconstitution, NMR/PRE/EPR spectroscopy, ITC assay, NMR titration [PMID: 22108166]/inference:alignment:ClustalW [PMID: 22206986]/inference:profile:Xplor-NIH, PyMOL, PDB2PQR, APBS, TALOS+, REDCAT, PROCHECK [PMID: 22206986]/note:FunctionalCategory: cell wall and cell processes/note:part of an operon required for fast ammonia secretion, rapid pH neutralization and growth of M.tuberculosis in acidic environments [PMID: 21410778]/note:does not form a transmembrane beta barrel [PMID: 20199110] [PMID: 22108166]/note:putatively functions in enriching zinc ions for further acquisition [PMID: 22108166] chr1 CDS 1003805 1003957 . + . ID=CDS1;locus_tag=Rv0900;gene=arfB;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes, belongs to the Rv0899-Rv0901 operon named ammonia release facilitator (arf) [PMID: 22206986], contributes to increasing expression of ompATb (low activity channel protein) [PMID: 21410778], required for fast ammonia secretion, rapid pH neutralization and growth of M.tuberculosis in acidic environments [PMID: 21410778] chr1 CDS 1003957 1004484 . + . ID=CDS1;locus_tag=Rv0901;gene=arfC;product=antigen;Experiment=DESCRIPTION:protein expression and purification, SDS-PAGE, survival ratio, gamma interferon, apoptosis ratio [PMID: 19168955]/note:FunctionalCategory: cell wall and cell processes/note:belongs to the Rv0899-Rv0901 operon named ammonia release facilitator (arf) [PMID: 22206986]/note:part of an operon required for fast ammonia secretion, rapid pH neutralization and growth of M.tuberculosis in acidic environments [PMID: 21410778]/note:regulates Rv0899 expression at a post-transcriptional level in M.bovis BCG [PMID: 21802366]/note:contributes to increasing expression of ompATb (low activity channel protein) [PMID: 21410778]/note:pro-apoptotic antigen [PMID: 19168955]/note:probably involved in NO release during infection [PMID: 19168955] chr1 CDS 1004501 1005841 . - . ID=CDS1;locus_tag=Rv0902c;product=Two component sensor histidine kinase PrrB;note=FunctionalCategory: regulatory proteins chr1 CDS 1005852 1006562 . - . ID=CDS1;locus_tag=Rv0903c;product=Two component response transcriptional regulatory protein PrrA;note=FunctionalCategory: regulatory proteins chr1 CDS 1006693 1008180 . - . ID=CDS1;locus_tag=Rv0904c;product=Putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) AccD3 (accase beta chain);note=FunctionalCategory: lipid metabolism chr1 CDS 1008207 1008938 . + . ID=CDS1;locus_tag=Rv0905;product=Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 1008944 1010062 . + . ID=CDS1;locus_tag=Rv0906;product=Conserved protein/Putative N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.4.54 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4qn9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0043227/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0001523/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0009395/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0042622/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0102200/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0006644/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0004620/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0007568/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0035900/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=0070290/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A,Ontology_term=1903999/note:identified by similarity of predicted tertiary structure to PDB 4qn9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qn9A chr1 CDS 1010136 1011734 . + . ID=CDS1;locus_tag=Rv0907;product=putative beta-lactamase;Inference=profile:positional Shannon relative entropy method [PMID: 18022770]/note:FunctionalCategory: cell wall and cell processes/note:putative cAMP Receptor Protein (CRP) binding protein [PMID: 18022770]/note:belongs to the AmpC class of beta-lactamase [PMID: 18022770]/note:possible involvement in PZA resistance (only one strain affected) [PMID: 27759369]/note:induced by the anthraquinone 4-deoxybostrycin [PMID: 23434859]/note:possible involvement in alpha-glucan biosynthesis [PMID: 27936238]/note:shown to harbor significantly less transposon insertions in absence of trehalose (otsA mutant strain with no trehalose) [PMID: 27936238];EC_number=3.5.2.6,EC_number=3.5.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,2qmiA,3o3vA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008800/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA,Ontology_term=0017001/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 2wzxA,2qz6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wzxA,2qz6A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1zkjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zkjA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3wrtA,1zkjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wrtA,1zkjA,Ontology_term=0033252/note:identified by similarity of predicted tertiary structure to PDB 2wzxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wzxA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,Ontology_term=0030288/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA chr1 CDS 1011731 1014124 . + . ID=CDS1;locus_tag=Rv0908;product=Probable metal cation transporter ATPase P-type CtpE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1014681 1014860 . + . ID=CDS1;locus_tag=Rv0909;product=putative Type II Antitoxin;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Tested for the neutralization of the toxin in M. smegmatis[PMID: 24662523] chr1 CDS 1014866 1015300 . + . ID=CDS1;locus_tag=Rv0910;product=putative Type II toxin;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Tested for growth inhibition in M.smegmatis[PMID: 24662523] chr1 CDS 1015398 1016171 . + . ID=CDS1;locus_tag=Rv0911;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Expression of the gene product is predicted to be regulated by SigG[PMID: 23871545] chr1 CDS 1016236 1016685 . + . ID=CDS1;locus_tag=Rv0912;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, induced by SigG protein [PMID: 23871545] chr1 CDS 1017217 1018725 . - . ID=CDS1;locus_tag=Rv0913c;product=Possible dioxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1018727 1019965 . - . ID=CDS1;locus_tag=Rv0914c;product=Possible lipid carrier protein or keto acyl-CoA thiolase;note=FunctionalCategory: lipid metabolism chr1 CDS 1020058 1021329 . - . ID=CDS1;locus_tag=Rv0915c;gene=PPE14;product=T cell antigen;note=gene_synonym MTB41;Experiment=DESCRIPTION: Protein expression and purification, cytokine assays, cytotoxic T lymphocyte (CTL) assay. [PMID: 15917115]/note:FunctionalCategory: PE/PPE/note:Induces CD4 cell response but not CD8 T cell response [PMID: 15917115] chr1 CDS 1021344 1021643 . - . ID=CDS1;locus_tag=Rv0916c;gene=PE7;product=PE family protein PE7;note=gene_synonym MTB10, associated with and linked in a gene pair with Rv0915c (MTB41/PPE14) antigen [PMID: 11120845], FunctionalCategory: PE/PPE chr1 CDS 1022087 1023868 . + . ID=CDS1;locus_tag=Rv0917;product=Possible glycine betaine transport integral membrane protein BetP;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1024211 1024687 . + . ID=CDS1;locus_tag=Rv0918;product=Conserved protein;Inference=similar to AA sequence:PSI-BLAST [PMID: 19493340]/inference:alignment:Muscle [PMID: 19493340]/inference:profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:40843 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in antibiotic resistance [PMID: 19493340]/note:Putatively linked to N-acetyltransferase activity [PMID: 22485162] chr1 CDS 1024684 1025184 . + . ID=CDS1;locus_tag=Rv0919;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1025497 1026816 . - . ID=CDS1;locus_tag=Rv0920c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1027104 1027685 . + . ID=CDS1;locus_tag=Rv0921;product=Possible resolvase;note=FunctionalCategory: insertion seqs and phages;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1027685 1029337 . + . ID=CDS1;locus_tag=Rv0922;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1029513 1030577 . - . ID=CDS1;locus_tag=Rv0923c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1030578 1031864 . - . ID=CDS1;locus_tag=Rv0924c;product=Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1031896 1032633 . - . ID=CDS1;locus_tag=Rv0925c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1032710 1033786 . - . ID=CDS1;locus_tag=Rv0926c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1033840 1034631 . - . ID=CDS1;locus_tag=Rv0927c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1034903 1036015 . + . ID=CDS1;locus_tag=Rv0928;product=Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1036028 1037002 . + . ID=CDS1;locus_tag=Rv0929;product=Phosphate-transport integral membrane ABC transporter PstC2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1036999 1037925 . + . ID=CDS1;locus_tag=Rv0930;product=Probable phosphate-transport integral membrane ABC transporter PstA1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1037920 1039914 . - . ID=CDS1;locus_tag=Rv0931c;product=Transmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D);note=FunctionalCategory: regulatory proteins chr1 CDS 1039936 1041048 . - . ID=CDS1;locus_tag=Rv0932c;product=Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1041264 1042094 . + . ID=CDS1;locus_tag=Rv0933;product=Phosphate-transport ATP-binding protein ABC transporter PstB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1042115 1043239 . + . ID=CDS1;locus_tag=Rv0934;product=Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1043299 1044315 . + . ID=CDS1;locus_tag=Rv0935;product=Phosphate-transport integral membrane ABC transporter PstC1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1044317 1045222 . + . ID=CDS1;locus_tag=Rv0936;product=Phosphate-transport integral membrane ABC transporter PstA2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1045199 1046020 . - . ID=CDS1;locus_tag=Rv0937c;product=DNA end-binding protein, Mku;note=FunctionalCategory: information pathways chr1 CDS 1046136 1048415 . + . ID=CDS1;locus_tag=Rv0938;product=ATP dependent DNA ligase LigD (ATP dependent polydeoxyribonucleotide synthase) (thermostable DNA ligase) (ATP dependent polynucleotide ligase) (sealase) (DNA repair enzyme) (DNA joinase);note=FunctionalCategory: information pathways chr1 CDS 1048412 1050346 . + . ID=CDS1;locus_tag=Rv0939;product=Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1050593 1051459 . - . ID=CDS1;locus_tag=Rv0940c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1051544 1052317 . - . ID=CDS1;locus_tag=Rv0941c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Gene predicted to be induced by SigF[PMID: 22307756], possible phosphatase, strongly homologous to Rv1364c domains, identified by similarity of predicted tertiary structure to PDB 3ke6A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ke6A chr1 CDS 1052360 1052638 . + . ID=CDS1;locus_tag=Rv0942;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1052696 1053736 . - . ID=CDS1;locus_tag=Rv0943c;product=Probable monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1053765 1054241 . + . ID=CDS1;locus_tag=Rv0944;product=Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase);note=FunctionalCategory: information pathways chr1 CDS 1054247 1055008 . + . ID=CDS1;locus_tag=Rv0945;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1055024 1056685 . - . ID=CDS1;locus_tag=Rv0946c;product=Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1057300 1057530 . - . ID=CDS1;locus_tag=Rv0947c;product=Probable mycolyl transferase, pseudogene;note=FunctionalCategory: lipid metabolism chr1 CDS 1057646 1057963 . - . ID=CDS1;locus_tag=Rv0948c;product=Chorismate mutase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1058260 1060575 . + . ID=CDS1;locus_tag=Rv0949;product=Probable ATP-dependent DNA helicase II UvrD1;note=FunctionalCategory: information pathways chr1 CDS 1060656 1061654 . - . ID=CDS1;locus_tag=Rv0950c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1061964 1063127 . + . ID=CDS1;locus_tag=Rv0951;product=Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1063140 1064051 . + . ID=CDS1;locus_tag=Rv0952;product=Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1064114 1064962 . - . ID=CDS1;locus_tag=Rv0953c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1065127 1066038 . + . ID=CDS1;locus_tag=Rv0954;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, homologous to the 34 kDa antigenic protein of M. avium [PMID: 10068253] chr1 CDS 1066078 1067445 . + . ID=CDS1;locus_tag=Rv0955;gene=perM;product=Persistence-associated integral membrane protein;Experiment=DESCRIPTION:mutagenesis, in vivo macrophage infection/note:FunctionalCategory: cell wall and cell processes/note:highly conserved among mycobacteria and actinobacteria but has no homologues in other species [PMID: 25658098]/note:necessary for growth and survival in low magnesium [PMID: 25658098]/note:hypothesized to play a role in cell division [PMID: 25658098]/note:shown to protect M.tuberculosis from acid shock [PMID: 18641659]/note:expressed during intracellular stress response [PMID: 22280836] chr1 CDS 1067561 1068208 . + . ID=CDS1;locus_tag=Rv0956;product=Probable 5'-phosphoribosylglycinamide formyltransferase PurN (GART) (gar transformylase) (5'-phosphoribosylglycinamide transformylase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1068205 1069776 . + . ID=CDS1;locus_tag=Rv0957;product=Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1069883 1071262 . + . ID=CDS1;locus_tag=Rv0958;product=Possible magnesium chelatase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1071255 1073273 . + . ID=CDS1;locus_tag=Rv0959;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1073327 1073548 . + . ID=CDS1;locus_tag=Rv0959A;product=Possible antitoxin VapB9;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1073545 1073928 . + . ID=CDS1;locus_tag=Rv0960;product=Possible toxin VapC9;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1074074 1074421 . + . ID=CDS1;locus_tag=Rv0961;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes, deletion found in PZA resistant strain (hypothesized to be IS6110 mediated deletion) [PMID: 15184436] chr1 CDS 1074440 1075114 . - . ID=CDS1;locus_tag=Rv0962c;product=Possible lipoprotein LprP;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1075297 1076097 . - . ID=CDS1;locus_tag=Rv0963c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1076196 1076678 . - . ID=CDS1;locus_tag=Rv0964c;product=Hypothetical protein;Experiment=ITC Titration [PMID: 25434965]/inference:profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:40843 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to contain a PhoP binding site [PMID: 25434965]/note:Putatively involved in membrane associated processes [PMID: 22485162] chr1 CDS 1076778 1077197 . - . ID=CDS1;locus_tag=Rv0965c;product=Putative ESAT-6 like protein;note=FunctionalCategory: conserved hypotheticals;Inference=ab initio prediction:Protein fold recognition algorithm via PHYRE2 [PMID: 25467293]/inference:profile:computationaly intensive pipline prediction of unassigned regions (PURE) [PMID: 25467293] chr1 CDS 1077233 1077835 . - . ID=CDS1;locus_tag=Rv0966c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Found to be up-regulated in an in vitro model of TB infection of the human brain microvascular endothelium. [PMID: 16586367] chr1 CDS 1077975 1078334 . + . ID=CDS1;locus_tag=Rv0967;product=Copper-sensitive operon repressor CsoR;note=FunctionalCategory: regulatory proteins chr1 CDS 1078391 1078687 . + . ID=CDS1;locus_tag=Rv0968;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1078677 1081055 . + . ID=CDS1;locus_tag=Rv0969;product=Probable metal cation transporter P-type ATPase CtpV;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1081052 1081684 . + . ID=CDS1;locus_tag=Rv0970;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes, part of the Rv0967-Rv0970 operon named as copper-sensitive operon [PMID: 17143269], repressed by CsoR and the repression is reversed in the presence of copper [PMID: 21166899] [PMID: 26999439], Possible role in Copper homeostasis in macrophages and dendritic cells [PMID: 27803888], Regulated by several Transcriptional factor including Rv0324 and Rv1423 in dendritic cell and Rv0081 and Rv2324 in macrophages. chr1 CDS 1081775 1082584 . - . ID=CDS1;locus_tag=Rv0971c;product=Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 1082584 1083750 . - . ID=CDS1;locus_tag=Rv0972c;product=Acyl-CoA dehydrogenase FadE12;note=FunctionalCategory: lipid metabolism chr1 CDS 1083747 1085750 . - . ID=CDS1;locus_tag=Rv0973c;product=Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP);note=FunctionalCategory: lipid metabolism chr1 CDS 1085756 1087345 . - . ID=CDS1;locus_tag=Rv0974c;product=Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2;note=FunctionalCategory: lipid metabolism chr1 CDS 1087348 1088496 . - . ID=CDS1;locus_tag=Rv0975c;product=Probable acyl-CoA dehydrogenase FadE13;note=FunctionalCategory: lipid metabolism chr1 CDS 1088493 1090175 . - . ID=CDS1;locus_tag=Rv0976c;product=Conserved hypothetical protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:06304 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively related to synthesis and oxidation of fatty acids[PMID: 22485162] chr1 CDS 1090373 1093144 . + . ID=CDS1;locus_tag=Rv0977;gene=PE_PGRS16;product=Probable cell surface antigen;Experiment=DESCRIPTION: Protein expression and purification, surface extraction, immunoblotting, in vitro assays [PMID: 18957600]/note:FunctionalCategory: PE/PPE/note:lack proteolytic activity despite having an aspartic proteinase-like domain [PMID: 23923105]/note:increases nitrogen production in macrophages [PMID: 18957600] chr1 CDS 1093361 1094356 . - . ID=CDS1;locus_tag=Rv0978c;gene=PE_PGRS17;product=B-cell antigen;Experiment=DESCRIPTION: Protein expression and purification, PCR, ELISA. [PMID: 17687113],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Induces dendritic cell maturation and secretion of pro-inflammatory cytokines [PMID: 20176745]/note:Recognizes TLR2 [PMID: 20176745]/note:Possibly regulated by ERK kinase [PMID: 23663047]/note:Possibly facilitates pathogen survival through modifying macrophage gene expression [PMID: 23663047]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 1094670 1094864 . - . ID=CDS1;locus_tag=Rv0979c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1094886 1095059 . + . ID=CDS1;locus_tag=Rv0979A;product=50S ribosomal protein L32 RpmF;note=FunctionalCategory: information pathways chr1 CDS 1095078 1096451 . - . ID=CDS1;locus_tag=Rv0980c;gene=PE_PGRS18;product=PE-PGRS family protein PE_PGRS18;note=FunctionalCategory: PE/PPE, Associated with mycobacterial cell envelope. [PMID: 27987050], Showed differential response to stresses and altered the production of host cytokines IL-6, IL1B, IL-12p40 and IL-10. [PMID: 27987050], Enhanced survival within macrophages by attenuating the apoptosis of macrophages. [PMID: 27987050] chr1 CDS 1096822 1097508 . + . ID=CDS1;locus_tag=Rv0981;product=Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein);note=FunctionalCategory: regulatory proteins chr1 CDS 1097508 1099022 . + . ID=CDS1;locus_tag=Rv0982;product=Two component sensor kinase MprB;note=FunctionalCategory: regulatory proteins chr1 CDS 1099066 1100460 . + . ID=CDS1;locus_tag=Rv0983;product=Probable serine protease PepD (serine proteinase) (MTB32B);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1100460 1101005 . + . ID=CDS1;locus_tag=Rv0984;product=Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha- hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1101025 1101480 . - . ID=CDS1;locus_tag=Rv0985c;product=Possible large-conductance ion mechanosensitive channel MscL;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1101803 1102549 . + . ID=CDS1;locus_tag=Rv0986;product=Probable adhesion component transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1102542 1105109 . + . ID=CDS1;locus_tag=Rv0987;product=Probable adhesion component transport transmembrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1105116 1106276 . + . ID=CDS1;locus_tag=Rv0988;product=Possible conserved exported protein;note=FunctionalCategory: cell wall and cell processes, Highly expressed in vivo [PMID: 15070764] chr1 CDS 1106405 1107382 . - . ID=CDS1;locus_tag=Rv0989c;product=Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1107443 1108099 . - . ID=CDS1;locus_tag=Rv0990c;gene=hsp22.5;product=Probable heat shock protein (22.5 kDa);Experiment=DESCRIPTION:Gene knockout combined with proteomic and transcriptomic analysis to infer regulon, nanoLC-MS/MS[PMID: 21602349]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 1108172 1108504 . - . ID=CDS1;locus_tag=Rv0991c;product=Conserved serine rich protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:COG:2231 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in biosynthetic processes [PMID: 22485162] chr1 CDS 1108578 1109171 . - . ID=CDS1;locus_tag=Rv0992c;product=probable 5,10-Methenyltetrahydrofolate synthase;Experiment=DESCRIPTION:Recombinant gene expression complementation study, 5,10-Methenyltetrahydrofolate synthase assay in M.smegmatis[PMID: 21372133]/note:FunctionalCategory: conserved hypotheticals/note:putatively utilizes folinic acid/note:Alternative name:5-formyltetrahydrofolate cyclo-ligase;EC_number=6.3.3.2 chr1 CDS 1109272 1110192 . + . ID=CDS1;locus_tag=Rv0993;product=UTP--glucose-1-phosphate uridylyltransferase GalU (UDP-glucose pyrophosphorylase) (UDPGP) (alpha-D-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1110269 1111549 . + . ID=CDS1;locus_tag=Rv0994;product=Probable molybdopterin biosynthesis protein MoeA1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1111612 1112223 . + . ID=CDS1;locus_tag=Rv0995;product=Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5);note=FunctionalCategory: information pathways chr1 CDS 1112384 1113460 . + . ID=CDS1;locus_tag=Rv0996;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, identified as a hub (highly connected) gene in the protein-protein interaction network (STRING) of M. tuberculosis [PMID: 24056838] chr1 CDS 1114293 1114724 . + . ID=CDS1;locus_tag=Rv0997;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be regulated by SigE[PMID: 20061478] chr1 CDS 1114748 1115749 . + . ID=CDS1;locus_tag=Rv0998;product=cAMP-dependent lysine acetyltransferase;Experiment=DESCRIPTION:mass spectrometry, in vitro deacylation assays, FadD assays, immunoprecipitation, protein purification and characterization[PMID: 23553634]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.3.1.32 chr1 CDS 1115767 1116525 . + . ID=CDS1;locus_tag=Rv0999;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1116531 1117148 . - . ID=CDS1;locus_tag=Rv1000c;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2iuwA,3btxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iuwA,3btxA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2iuwA,3btxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iuwA,3btxA chr1 CDS 1117185 1118393 . + . ID=CDS1;locus_tag=Rv1001;product=Probable arginine deiminase ArcA (adi) (ad) (arginine dihydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1118428 1119939 . - . ID=CDS1;locus_tag=Rv1002c;gene=pmt;product=polyprenyl-phosphate dependent protein O-mannosyltransferase (PMT);Experiment=DESCRIPTION:recombinant protein expression and purification, LC-ESI-MS/MS, in vitro protein mannosylation assay, mutagenesis [PMID: 16081738]/inference:alignment:ClustalW [PMID: 16081738]/note:FunctionalCategory: cell wall and cell processes/note:cytoplasmic membrane protein that catalyzes the addition of mannose (carried by a polyisoprenoid carrier lipid as donor) to serine or threonine residues of proteins in an alpha-glycosidic linkage [PMID: 17975704] [PMID: 16081738]/note:study shows that PMT is crucial for virulence [PMID: 23550160]/note:down-regulated in the presence of rifampicin in MDR-TB Beijing strain [PMID: 21512166];EC_number=2.4.1.- chr1 CDS 1120022 1120879 . + . ID=CDS1;locus_tag=Rv1003;product=Conserved protein/putative rRNA (cytosine-2'-O-)-methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA,Ontology_term=0070677/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA,Ontology_term=0000453/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 3kwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kwpA chr1 CDS 1120889 1122148 . - . ID=CDS1;locus_tag=Rv1004c;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1122222 1123598 . - . ID=CDS1;locus_tag=Rv1005c;product=Probable para-aminobenzoate synthase component I PABD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1123714 1125417 . + . ID=CDS1;locus_tag=Rv1006;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1125444 1127003 . - . ID=CDS1;locus_tag=Rv1007c;product=Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase);note=FunctionalCategory: information pathways chr1 CDS 1127089 1127883 . + . ID=CDS1;locus_tag=Rv1008;product=Probable deoxyribonuclease TatD (YJJV protein);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1128091 1129179 . + . ID=CDS1;locus_tag=Rv1009;product=Probable resuscitation-promoting factor RpfB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1129152 1130105 . + . ID=CDS1;locus_tag=Rv1010;product=Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase);note=FunctionalCategory: information pathways chr1 CDS 1130191 1131111 . + . ID=CDS1;locus_tag=Rv1011;product=Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1131128 1131421 . + . ID=CDS1;locus_tag=Rv1012;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1131625 1133259 . + . ID=CDS1;locus_tag=Rv1013;product=Putative polyketide synthase Pks16;note=FunctionalCategory: lipid metabolism chr1 CDS 1133333 1133908 . - . ID=CDS1;locus_tag=Rv1014c;product=Probable peptidyl-tRNA hydrolase Pth;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1133921 1134568 . - . ID=CDS1;locus_tag=Rv1015c;product=50S ribosomal protein L25 RplY;note=FunctionalCategory: information pathways chr1 CDS 1134785 1135465 . - . ID=CDS1;locus_tag=Rv1016c;product=Probable conserved lipoprotein LpqT;note=FunctionalCategory: cell wall and cell processes, TLR-2 like receptor involved in inhibition of Ag processing and IFN-γ-Induced CIITA Expression [PMID:27917375], induces apoptosis of and inhibits IFN-gamma induced MHC-II expression in macrophages [PMID:27917375], Product is similar to a zinc transporter in Bacillus subtilis. [PMID: 27630619] chr1 CDS 1135501 1136481 . - . ID=CDS1;locus_tag=Rv1017c;product=Probable ribose-phosphate pyrophosphokinase PrsA (phosphoribosyl pyrophosphate synthetase) (PRPP synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1136573 1138060 . - . ID=CDS1;locus_tag=Rv1018c;product=Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1138315 1138908 . + . ID=CDS1;locus_tag=Rv1019;product=Probable transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 1138967 1142671 . + . ID=CDS1;locus_tag=Rv1020;product=Probable transcription-repair coupling factor Mfd (TRCF);note=FunctionalCategory: information pathways chr1 CDS 1142671 1143648 . + . ID=CDS1;locus_tag=Rv1021;gene=mazG;product=nucleoside triphosphate pyrophosphohydrolase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:enzymatic activity assay and gene knockout[PMID: 20529853];EC_number=3.6.1.8,EC_number=3.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3craA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0009267/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0006203/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0047429/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0046061/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0046076/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0046047/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0046081/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0047693/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA,Ontology_term=0046052/note:identified by similarity of predicted tertiary structure to PDB 3craA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3craA chr1 CDS 1143736 1144467 . + . ID=CDS1;locus_tag=Rv1022;product=Probable conserved lipoprotein LpqU;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1144564 1145853 . + . ID=CDS1;locus_tag=Rv1023;product=Probable enolase Eno;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1145858 1146544 . + . ID=CDS1;locus_tag=Rv1024;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1146561 1147028 . + . ID=CDS1;locus_tag=Rv1025;product=Conserved protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:COG:1507 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Putatively involved in cell division [PMID: 22485162] chr1 CDS 1147019 1147978 . + . ID=CDS1;locus_tag=Rv1026;gene=ppx2;product=exopolyphosphatase;Experiment=DESCRIPTION:recombinant in vitro expression, protein purification, polyphosphatase enzyme activity assay, conditional gene knockdown, transmission electron microscopy, RNA-Seq [PMID: 25784702]/inference:alignment:ClustalW [PMID: 19304823]/note:FunctionalCategory: virulence, detoxification, adaptation/note:has hydrolytic activity against long-chain polyphosphate [PMID:25784702]/note:gene knockdown reduces susceptibility to isoniazid [PMID:25784702]/note:gene knockdown increases resistance to heat and low pH [PMID:25784702]/note:gene knockdown increases cell wall thickness while decreasing permeability [PMID:25784702]/note:gene knockdown enhances cellular survival during macrophage infection [PMID:25784702]/note:gene knockdown of results in showed global transcriptional changes, including reduced expression of genes encoding enzymes involved in glycerol-3-phosphate (G3P) synthesis [PMID:25784702]/note:induced and exported in vivo [PMID: 28442606];EC_number=3.6.1.11,EC_number=3.6.1.40 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1t6cA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.6.1.11 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3mdqA,1t6cA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1t6cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t6cA,Ontology_term=0004309/note:identified by similarity of predicted tertiary structure to PDB 3mdqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mdqA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3mdqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mdqA,Ontology_term=0016462/note:identified by similarity of predicted tertiary structure to PDB 1t6cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t6cA,Ontology_term=0006793/note:identified by similarity of predicted tertiary structure to PDB 1t6cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t6cA chr1 CDS 1148427 1149107 . - . ID=CDS1;locus_tag=Rv1027c;product=Probable transcriptional regulatory protein KdpE;note=FunctionalCategory: regulatory proteins chr1 CDS 1149104 1151686 . - . ID=CDS1;locus_tag=Rv1028c;product=Probable sensor protein KdpD;note=FunctionalCategory: regulatory proteins chr1 CDS 1151920 1152012 . + . ID=CDS1;locus_tag=Rv1028A;gene=kdpF;product=Probable membrane protein KdpF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1152012 1153727 . + . ID=CDS1;locus_tag=Rv1029;product=Probable potassium-transporting ATPase a chain KdpA (potassium-translocating ATPase a chain) (ATP phosphohydrolase [potassium-transporting] a chain) (potassium binding and translocating subunit A);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1153724 1155853 . + . ID=CDS1;locus_tag=Rv1030;product=Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1155853 1156422 . + . ID=CDS1;locus_tag=Rv1031;product=Probable potassium-transporting ATPase C chain KdpC (potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1156426 1157955 . - . ID=CDS1;locus_tag=Rv1032c;product=Two component sensor histidine kinase TrcS;note=FunctionalCategory: regulatory proteins chr1 CDS 1157963 1158736 . - . ID=CDS1;locus_tag=Rv1033c;product=Two component transcriptional regulator TrcR;note=FunctionalCategory: regulatory proteins chr1 CDS 1158918 1159307 . - . ID=CDS1;locus_tag=Rv1034c;product=Probable transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1159375 1160061 . - . ID=CDS1;locus_tag=Rv1035c;product=Probable transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1160095 1160433 . - . ID=CDS1;locus_tag=Rv1036c;product=Probable IS1560 transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1160544 1160828 . - . ID=CDS1;locus_tag=Rv1037c;product=Putative ESAT-6 like protein EsxI (ESAT-6 like protein 1);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1160855 1161151 . - . ID=CDS1;locus_tag=Rv1038c;product=ESAT-6 like protein EsxJ (ESAT-6 like protein 2);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1161297 1162472 . - . ID=CDS1;locus_tag=Rv1039c;gene=MPER1/PPE15;product=Probable mycobacterial perilipin-1;Experiment=DESCRIPTION: Bacterial culture, generation of mutant genes via transduction and complementation of deletion mutant, microscopic analysis, radiolabelling of lipid in in vitro granuloma model [PMID: 27325376],Experiment=EXISTENCE: Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Required for triacylglycerol accumulation under dormancy-inducing conditions. [PMID: 27325376]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642]/note:influences entry into dormancy inducing conditions decreases tolerance of Mtb to rifampicin under dormancy-inducing conditions [PMID: 27325376]/note:plays a critical role in TAG-containing lipid droplets homeostasis [PMID: 27325376] chr1 CDS 1162549 1163376 . - . ID=CDS1;locus_tag=Rv1040c;gene=PE8;product=PE family protein PE8;note=FunctionalCategory: PE/PPE chr1 CDS 1164572 1165435 . - . ID=CDS1;locus_tag=Rv1041c;product=Probable is like-2 transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1165092 1165499 . - . ID=CDS1;locus_tag=Rv1042c;product=Probable is like-2 transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1165781 1166806 . - . ID=CDS1;locus_tag=Rv1043c;product=Conserved hypothetical protein;Experiment=DESCRIPTION:microarrays, recombinant protein expression, LC/MS-MS, EMSA, Phagosome maturation assay [PMID: 20688819]/note:FunctionalCategory: conserved hypotheticals/note:Probable Htr-A like serine protease [PMID: 20688819] chr1 CDS 1167053 1167676 . + . ID=CDS1;locus_tag=Rv1044;product=Conserved hypothetical protein;Inference=similar to AA sequence:PSI-BLAST, COG:5340 [PMID: 21908672]/inference:profile:HHpred, hidden Markov models [PMID: 21908672]/inference:alignment:MUSCLE [PMID: 21908672]/note:FunctionalCategory: conserved hypotheticals/note:Putative type IV antitoxin in toxin-antitoxin system with Rv1045 [PMID: 21908672]/note:possible toxin/note:putative DNA-binding protein/note:Strong homology to Rv2827c, which likely binds DNA/note:identified by similarity of predicted tertiary structure to PDB 1zelB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zelB chr1 CDS 1167673 1168554 . + . ID=CDS1;locus_tag=Rv1045;product=Hypothetical protein;Inference=similar to AA sequence:PSI-BLAST [PMID: 21908672]/inference:profile:HHpred, hidden Markov models [PMID: 21908672]/inference:alignment:MUSCLE [PMID: 21908672]/note:FunctionalCategory: conserved hypotheticals/note:Putative type IV toxin in toxin-antitoxin system with Rv1044 [PMID: 21908672] chr1 CDS 1168704 1169228 . - . ID=CDS1;locus_tag=Rv1046c;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 1169423 1170670 . + . ID=CDS1;locus_tag=Rv1047;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1171038 1172153 . - . ID=CDS1;locus_tag=Rv1048c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1172386 1172832 . + . ID=CDS1;locus_tag=Rv1049;product=Probable transcriptional repressor protein/probable transcription factor;note=FunctionalCategory: regulatory proteins, Hypothesized that in response to growth on cholesterol, Rv1049 up-regulates the transcription of VapBC33 and the toxin VapC3 degrades mRNA transcripts involved in the uptake and metabolism of carbon sources present during wild-type growth, i.e., glycerol [PMID: 25232098], Controls cholesterol utilization in M. tuberculosis during infection in the host [PMID: 25232098], Together with Rv0081 Rv1049, controls the mce1 operon, consisting of six mce genes (Rv0169–Rv0174), two yrbE genes (Rv0167, Rv0168), and four mce-associated genes (Rv0175–Rv0178), extensively connected transcriptional regulator [PMID: 27356881], Target genes regulated by Rv1049 are down-regulated by bedaquiline [PMID: 27573104], Regulates both sigK and its cognate anti-sigma factor gene rskA [PMID: 27029515], Oxidation-sensing regulator [PMID: 22992749];Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 4fx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fx0A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 4fx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fx0A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4fx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fx0A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 4fx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fx0A,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 4fx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fx0A chr1 CDS 1172881 1173786 . + . ID=CDS1;locus_tag=Rv1050;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1173945 1174700 . - . ID=CDS1;locus_tag=Rv1051c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1175723 1176112 . + . ID=CDS1;locus_tag=Rv1052;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1176011 1176286 . - . ID=CDS1;locus_tag=Rv1053c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1176928 1177242 . + . ID=CDS1;locus_tag=Rv1054;product=Probable integrase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1177239 1177373 . + . ID=CDS1;locus_tag=Rv1055;product=Possible integrase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1177628 1178392 . + . ID=CDS1;locus_tag=Rv1056;product=Putative Antigen;Experiment=ELISPOT, Whole blood Assay, T-cell Depletion assay, Fc Receptor Blocking Assay, Phagocytosis by Flow Cytometry, Human Antibodies Isotyping Assay [PMID: 28438994]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 1179396 1180577 . + . ID=CDS1;locus_tag=Rv1057;product=putative seven-bladed beta-propeller of unknown function;note=FunctionalCategory: conserved hypotheticals;Experiment=expression analysis using SCOTS probes [PMID: 16352831]/inference:alignment:structural alignment via hidden Markov Models [PMID: 16352831]/inference:protein motif:PDB:1L0Q [PMID: 16352831]/note:regulated by TrcR/note:putatively involved in early growth in human macrophages/note:up regulated on mmpL3 deletion in M. tuberculosis [PMID: 28240248] chr1 CDS 1180684 1182315 . + . ID=CDS1;locus_tag=Rv1058;product=Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1182391 1183455 . + . ID=CDS1;locus_tag=Rv1059;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1183508 1183981 . + . ID=CDS1;locus_tag=Rv1060;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1184015 1184878 . + . ID=CDS1;locus_tag=Rv1061;product=Conserved protein/putative pentosyltransferase/putative linear amide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.4.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1gph1,1ecgB/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4zfjA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016811/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0006541/note:identified by similarity of predicted tertiary structure to PDB 1ecgB,4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,4zfjA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0052699/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,Ontology_term=0004044/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0009113/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0006189/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0009116/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0052704/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,Ontology_term=0016757/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0006164/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB chr1 CDS 1184883 1185740 . + . ID=CDS1;locus_tag=Rv1062;product=probable serine hydrolase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625];EC_number=3.1.-.- chr1 CDS 1185741 1186823 . - . ID=CDS1;locus_tag=Rv1063c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1186904 1187323 . - . ID=CDS1;locus_tag=Rv1064c;product=Possible lipoprotein LpqV;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1187435 1188001 . + . ID=CDS1;locus_tag=Rv1065;product=putative dioxygenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.13.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3elnA,3eqeA,3ussA,2atfA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0051384/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0007595/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0051149/note:identified by similarity of predicted tertiary structure to PDB 2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2atfA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3elnA,3eqeA,3ussA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,3eqeA,3ussA,2atfA,Ontology_term=0043200/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0019448/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0016702/note:identified by similarity of predicted tertiary structure to PDB 3elnA,3eqeA,3ussA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,3eqeA,3ussA,2atfA,Ontology_term=0046439/note:identified by similarity of predicted tertiary structure to PDB 3elnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,Ontology_term=0005506/note:identified by similarity of predicted tertiary structure to PDB 3elnA,3eqeA,3ussA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,3eqeA,3ussA,2atfA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3elnA,3eqeA,3ussA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,3eqeA,3ussA,2atfA,Ontology_term=0017172/note:identified by similarity of predicted tertiary structure to PDB 3elnA,3eqeA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,3eqeA,2atfA,Ontology_term=0033762/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0008198/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0045471/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0051591/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0042412/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2atfA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3elnA,3eqeA,3ussA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,3eqeA,3ussA,2atfA,Ontology_term=0019530/note:identified by similarity of predicted tertiary structure to PDB 2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2atfA,Ontology_term=0019452/note:identified by similarity of predicted tertiary structure to PDB 2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2atfA,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 3elnA,3eqeA,3ussA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,3eqeA,3ussA,2atfA,Ontology_term=0010243/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA,Ontology_term=0006534/note:identified by similarity of predicted tertiary structure to PDB 3elnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3elnA,2atfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3elnA,2atfA chr1 CDS 1187998 1188393 . + . ID=CDS1;locus_tag=Rv1066;product=putative sulfurtransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.8.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3olhA,1h4kX,1okgA,1uarA,1yt8A,3utnX,3ippB,1orbA,3d1pA,3hzuA,3aayB,2eg4A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0019499/note:identified by similarity of predicted tertiary structure to PDB 1okgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okgA,Ontology_term=0021510/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0001889/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0045202/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0051029/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0004792/note:identified by similarity of predicted tertiary structure to PDB 3olhA,1h4kX,1uarA,1yt8A,3utnX,3ippB,1orbA,3d1pA,3hzuA,3aayB,2eg4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,1h4kX,1uarA,1yt8A,3utnX,3ippB,1orbA,3d1pA,3hzuA,3aayB,2eg4A,Ontology_term=0002143/note:identified by similarity of predicted tertiary structure to PDB 3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3utnX,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3olhA,3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,3utnX,Ontology_term=0005615/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0035928/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0009636/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0001822/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 3olhA,3utnX,1orbA,3d1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,3utnX,1orbA,3d1pA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3olhA,1h4kX,1okgA,1uarA,1yt8A,3utnX,1orbA,3d1pA,3hzuA,3aayB,2eg4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,1h4kX,1okgA,1uarA,1yt8A,3utnX,1orbA,3d1pA,3hzuA,3aayB,2eg4A,Ontology_term=0030054/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0043005/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0030855/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2eg4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eg4A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0016784/note:identified by similarity of predicted tertiary structure to PDB 3olhA,1okgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,1okgA,Ontology_term=0009440/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0002098/note:identified by similarity of predicted tertiary structure to PDB 3utnX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3utnX,Ontology_term=0008097/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 3olhA,1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,1orbA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3olhA,1okgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,1okgA,Ontology_term=0070814/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA,Ontology_term=0005743/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0019343/note:identified by similarity of predicted tertiary structure to PDB 1okgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okgA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orbA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1h4kX,3utnX,1orbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1h4kX,3utnX,1orbA,Ontology_term=0019346/note:identified by similarity of predicted tertiary structure to PDB 3olhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3olhA chr1 CDS 1188421 1190424 . - . ID=CDS1;locus_tag=Rv1067c;gene=PE_PGRS19;product=PE-PGRS family protein PE_PGRS19;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 1190757 1192148 . - . ID=CDS1;locus_tag=Rv1068c;gene=PE_PGRS20;product=PE-PGRS family protein PE_PGRS20;note=FunctionalCategory: PE/PPE chr1 CDS 1192510 1194273 . - . ID=CDS1;locus_tag=Rv1069c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1194270 1195043 . - . ID=CDS1;locus_tag=Rv1070c;product=Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 1195055 1196092 . - . ID=CDS1;locus_tag=Rv1071c;product=Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 1196279 1197115 . + . ID=CDS1;locus_tag=Rv1072;product=Probable conserved transmembrane protein;Experiment=DESCRIPTION:Growth during hypoxia, RNA extraction, DNA microarrays, real time PCR [PMID: 25422323]/note:FunctionalCategory: cell wall and cell processes/note:Putative target of Clp protease chr1 CDS 1197231 1198082 . + . ID=CDS1;locus_tag=Rv1073;product=Conserved hypothetical protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:COG:1507 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in membrane associated processes [PMID: 22485162]/note:Gene product is a possible substrate for Clp protease [PMID: 25422323] chr1 CDS 1198156 1199373 . - . ID=CDS1;locus_tag=Rv1074c;product=Probable beta-ketoacyl CoA thiolase FadA3;note=FunctionalCategory: lipid metabolism chr1 CDS 1199426 1200370 . - . ID=CDS1;locus_tag=Rv1075c;product=Conserved exported protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1200767 1201660 . + . ID=CDS1;locus_tag=Rv1076;gene=LipU;product=Possible lipase LipU;Experiment=DESCRIPTION: Protein expression and purification, enzyme activity assay, substrate specificity, enzyme kinetic assay, site-directed mutagenesis. [PMID: 28164792]/note:FunctionalCategory: intermediary metabolism and respiration/note:Homologous to the human Hormone Sensitive Lipase (HSL) based on the presence of conserved motif 'GXSXG'. [PMID: 28164792]/note:Up-regulated Mycobacterium tuberculosis under nutritive stress. [PMID: 28164792]/note:Have esterase characteristics, might be esterase instead of lipase. [PMID: 28164792] chr1 CDS 1201717 1203111 . + . ID=CDS1;locus_tag=Rv1077;product=Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1203313 1204035 . + . ID=CDS1;locus_tag=Rv1078;product=Probable proline-rich antigen homolog Pra;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1204067 1205233 . + . ID=CDS1;locus_tag=Rv1079;product=Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1205304 1205798 . - . ID=CDS1;locus_tag=Rv1080c;product=Probable transcription elongation factor GreA (transcript cleavage factor GreA);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1205984 1206418 . - . ID=CDS1;locus_tag=Rv1081c;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1206520 1207386 . + . ID=CDS1;locus_tag=Rv1082;product=Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1207383 1207649 . + . ID=CDS1;locus_tag=Rv1083;product=Conserved hypothetical protein;Inference=profile:STRING database [PMID: 22485162]/inference:similar to AA sequence:NOG:13953 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be involved in membrane associated processes [PMID: 22485162] chr1 CDS 1207636 1209657 . + . ID=CDS1;locus_tag=Rv1084;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1209756 1210484 . - . ID=CDS1;locus_tag=Rv1085c;product=Possible hemolysin-like protein/putative membrane transporter receptor protein;note=FunctionalCategory: virulence, detoxification, adaptation;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:identified by similarity of predicted tertiary structure to PDB 5b2nA, 4xtlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5b2nA, 4xtlA chr1 CDS 1210595 1211383 . + . ID=CDS1;locus_tag=Rv1086;product=Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1211560 1213863 . + . ID=CDS1;locus_tag=Rv1087;gene=PE_PGRS21;product=PE-PGRS family protein PE_PGRS21;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 1214040 1214360 . + . ID=CDS1;locus_tag=Rv1087A;product=Putative prenyltransferase;note=FunctionalCategory: cell wall and cell processes;EC_number=2.5.1.68 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2vg1A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016765/note:identified by similarity of predicted tertiary structure to PDB 2vg1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vg1A chr1 CDS 1214513 1214947 . + . ID=CDS1;locus_tag=Rv1088;gene=PE9;product=CD8 T cell Antigen;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642],Experiment=DESCRIPTION: Cell culture, ELISPOT assay. [PMID: 23805289]/note:FunctionalCategory: PE/PPE/note:Forms heterodimer with PE10 (Rv1089) and induces macrophage apoptosis through Toll-like receptor 4. [PMID: 26031846]/note:Putatively involved in cell invasion for Mycobacterium tuberculosis [PMID: 26851205]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 1214769 1215131 . + . ID=CDS1;locus_tag=Rv1089;gene=PE10;product=PE family protein PE10;note=FunctionalCategory: PE/PPE, Forms a heterodimer with PE9 (Rv1088) and induces macrophage apoptosis through Toll-like receptor 4. [PMID: 26031846] chr1 CDS 1215517 1215621 . + . ID=CDS1;locus_tag=Rv1089A;product=Probable cellulase CelA2a (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1215599 1216054 . + . ID=CDS1;locus_tag=Rv1090;product=Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1216469 1219030 . + . ID=CDS1;locus_tag=Rv1091;gene=PE_PGRS22;product=PE-PGRS family protein PE_PGRS22;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 1219248 1220186 . - . ID=CDS1;locus_tag=Rv1092c;product=Probable pantothenate kinase CoaA (pantothenic acid kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1220574 1221854 . + . ID=CDS1;locus_tag=Rv1093;product=Serine hydroxymethyltransferase 1 GlyA1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1221959 1222786 . + . ID=CDS1;locus_tag=Rv1094;product=Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase);note=FunctionalCategory: lipid metabolism chr1 CDS 1222997 1224298 . + . ID=CDS1;locus_tag=Rv1095;product=Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1224385 1225260 . + . ID=CDS1;locus_tag=Rv1096;product=Possible glycosyl hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1225263 1226144 . - . ID=CDS1;locus_tag=Rv1097c;product=Probable membrane glycine and proline rich protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1226141 1227565 . - . ID=CDS1;locus_tag=Rv1098c;product=Probable fumarase Fum (fumarate hydratase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1227596 1228312 . - . ID=CDS1;locus_tag=Rv1099c;product=Fructose 1,6-bisphosphatase GlpX;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1228683 1229384 . + . ID=CDS1;locus_tag=Rv1100;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1229391 1230548 . - . ID=CDS1;locus_tag=Rv1101c;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1230660 1230971 . - . ID=CDS1;locus_tag=Rv1102c;product=Toxin MazF3;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1230971 1231291 . - . ID=CDS1;locus_tag=Rv1103c;product=Possible antitoxin MazE3;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1231301 1231990 . + . ID=CDS1;locus_tag=Rv1104;product=Possible para-nitrobenzyl esterase (fragment);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1232311 1232826 . + . ID=CDS1;locus_tag=Rv1105;product=Possible para-nitrobenzyl esterase (fragment);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1232844 1233956 . - . ID=CDS1;locus_tag=Rv1106c;product=3-beta-hydroxysteroid dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1233966 1234223 . - . ID=CDS1;locus_tag=Rv1107c;product=Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit);note=FunctionalCategory: information pathways chr1 CDS 1234213 1235460 . - . ID=CDS1;locus_tag=Rv1108c;product=Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit);note=FunctionalCategory: information pathways chr1 CDS 1235457 1236095 . - . ID=CDS1;locus_tag=Rv1109c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1236185 1237192 . + . ID=CDS1;locus_tag=Rv1110;product=Probable LYTB-related protein LytB2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1237209 1238192 . - . ID=CDS1;locus_tag=Rv1111c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1238255 1239328 . + . ID=CDS1;locus_tag=Rv1112;product=Probable GTP binding protein/probable GTPase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.5.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:2j69A,5ee0A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016887/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0009651/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=1901001/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2j69A,5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j69A,5ee0A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 2j69A,5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j69A,5ee0A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2j69A,5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j69A,5ee0A,Ontology_term=0003924/note:identified by similarity of predicted tertiary structure to PDB 2j69A,5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j69A,5ee0A,Ontology_term=0008289/note:identified by similarity of predicted tertiary structure to PDB 2j69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j69A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 5ee0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ee0A chr1 CDS 1239416 1239613 . + . ID=CDS1;locus_tag=Rv1113;product=Possible antitoxin VapB32;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1239610 1239984 . + . ID=CDS1;locus_tag=Rv1114;product=Possible toxin VapC32. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1240187 1240885 . + . ID=CDS1;locus_tag=Rv1115;product=Probable T-cell antigen/Possible exported protein/reactivation-associated antigen;Experiment=DESCRIPTION:Cell culture assays with peripheral blood mononuclear cells, IFN ELISA [PMID: 19440342]/note:FunctionalCategory: cell wall and cell processes/note:Intergenic region between Rv1115-Rv1116 predicted to be directly bound by sigma factor k [PMID: 17158685]/note:Enriched in acidic phagosomes [PMID: 16322769] chr1 CDS 1241003 1241188 . + . ID=CDS1;locus_tag=Rv1116;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1241115 1241390 . - . ID=CDS1;locus_tag=Rv1116A;product=Conserved hypothetical protein (fragment);note=FunctionalCategory: conserved hypotheticals chr1 CDS 1241633 1241956 . + . ID=CDS1;locus_tag=Rv1117;product=Conserved protein/putative monooxygenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.14.-.-;Ontology_term=0004497/note:identified by similarity of predicted tertiary structure to PDB 1y0hA,4hl9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y0hA,4hl9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1x7vC,2gffB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1x7vC,2gffB,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1y0hA,3e8oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y0hA,3e8oA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1y0hA,2gffB,1x7vC,4hl9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y0hA,2gffB,1x7vC,4hl9A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1y0hA,2gffB,1x7vC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y0hA,2gffB,1x7vC chr1 CDS 1241971 1242669 . - . ID=CDS1;locus_tag=Rv1118c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1242864 1243013 . - . ID=CDS1;locus_tag=Rv1119c;product=Putative Adenylate cyclase.;note=FunctionalCategory: conserved hypotheticals;EC_number=4.6.1.1 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4wp3A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004016/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,Ontology_term=0035556/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,Ontology_term=0016849/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,Ontology_term=0009190/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,Ontology_term=0006171/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 4wp3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A chr1 CDS 1243010 1243504 . - . ID=CDS1;locus_tag=Rv1120c;product=putative pseudogene from adenylyl cyclase/putative phosphorus-oxygen lyase;Inference=alignment:BLAST/note:FunctionalCategory: conserved hypotheticals/note:orthologous to M. avium 1120c, truncated protein that lacks key adenylyl cyclase residues [PMID: 18629044];EC_number=4.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1y11A,1culA,2w01A,1culB,2wz1A,1azsA,3uvjA,4yusA,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0004016/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0007165/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0035556/note:identified by similarity of predicted tertiary structure to PDB 1y11A,1culA,2w01A,1culB,2wz1A,1azsA,3uvjA,4yusA,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,1culA,2w01A,1culB,2wz1A,1azsA,3uvjA,4yusA,1wc4A,1fx2A,4clfA,Ontology_term=0071949/note:identified by similarity of predicted tertiary structure to PDB 4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4yusA,Ontology_term=0030818/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0016849/note:identified by similarity of predicted tertiary structure to PDB 1y11A,1culA,2w01A,1culB,2wz1A,1azsA,3uvjA,4yusA,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,1culA,2w01A,1culB,2wz1A,1azsA,3uvjA,4yusA,1wc4A,1fx2A,4clfA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4yusA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0006171/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009882/note:identified by similarity of predicted tertiary structure to PDB 4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4yusA,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0008289/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009785/note:identified by similarity of predicted tertiary structure to PDB 4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4yusA,Ontology_term=0009268/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009190/note:identified by similarity of predicted tertiary structure to PDB 1y11A,1culA,2w01A,1culB,2wz1A,1azsA,3uvjA,4yusA,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,1culA,2w01A,1culB,2wz1A,1azsA,3uvjA,4yusA,1wc4A,1fx2A,4clfA,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 1y11A,4yusA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,4yusA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A chr1 CDS 1243707 1245107 . + . ID=CDS1;locus_tag=Rv1121;product=Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1245129 1246151 . + . ID=CDS1;locus_tag=Rv1122;product=Probable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1246144 1247052 . - . ID=CDS1;locus_tag=Rv1123c;product=Possible peroxidase BpoB (non-haem peroxidase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1247127 1248077 . + . ID=CDS1;locus_tag=Rv1124;product=Probable epoxide hydrolase EphC (epoxide hydratase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1248082 1249326 . + . ID=CDS1;locus_tag=Rv1125;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1249330 1249935 . - . ID=CDS1;locus_tag=Rv1126c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1249932 1251404 . - . ID=CDS1;locus_tag=Rv1127c;product=Probable pyruvate, phosphate dikinase PpdK;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1251617 1252972 . - . ID=CDS1;locus_tag=Rv1128c;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1253074 1254534 . - . ID=CDS1;locus_tag=Rv1129c;gene=prpR;product=Propionate regulator, transcriptional regulator protein (regulation of methylcitrate and glyoxylate cycles);Experiment=DESCRIPTION: mutagenesis, metabolomic profiling (using GC/MS analysis), lipid analysis, macrophage infections [PMID: 22365605],Experiment=DESCRIPTION: mutagenesis, EMSA analysis (promoter binding), gene deletion, whole-cell immunoprecipitation assay, RNA extraction and reverse transcription [PMID: 22916289]/note:FunctionalCategory: regulatory proteins/note:required for intracellular growth in macrophages and for propionyl-coA metabolism in vitro [PMID: 22365605]/note:upregulated in response to starvation in vitro [PMID: 24268774]/note:also named as LrpG, (local regulatory protein of gltA1) as it was involved in the regulation of hypoxic response of the adjacent effector gene [PMID: 21193605]/note:induction of Rv1129c during hypoxic stress requires functional sigE [PMID: 21193605] chr1 CDS 1254555 1256135 . + . ID=CDS1;locus_tag=Rv1130;product=Possible methylcitrate dehydratase PrpD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1256132 1257313 . + . ID=CDS1;locus_tag=Rv1131;product=Probable methylcitrate synthase PrpC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1257325 1259055 . + . ID=CDS1;locus_tag=Rv1132;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1259067 1261346 . - . ID=CDS1;locus_tag=Rv1133c;product=Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1261922 1262158 . + . ID=CDS1;locus_tag=Rv1134;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1262272 1264128 . - . ID=CDS1;locus_tag=Rv1135c;gene=PPE16;product=PPE family protein PPE16;note=FunctionalCategory: PE/PPE chr1 CDS 1264314 1264556 . + . ID=CDS1;locus_tag=Rv1135A;product=Possible acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase);note=FunctionalCategory: lipid metabolism chr1 CDS 1264606 1264947 . + . ID=CDS1;locus_tag=Rv1136;product=Possible enoyl-CoA hydratase;note=FunctionalCategory: lipid metabolism chr1 CDS 1265087 1265455 . - . ID=CDS1;locus_tag=Rv1137c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1265472 1266488 . - . ID=CDS1;locus_tag=Rv1138c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1266485 1266985 . - . ID=CDS1;locus_tag=Rv1139c;product=putative methyltransferase;note=FunctionalCategory: cell wall and cell processes, Down-regulated in late-stationary phase [PMID: 23826872];EC_number=2.1.1.-;Ontology_term=0006481/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB,Ontology_term=0004671/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB chr1 CDS 1267347 1268195 . + . ID=CDS1;locus_tag=Rv1140;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1268203 1269009 . - . ID=CDS1;locus_tag=Rv1141c;product=Probable enoyl-CoA hydratase EchA11 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 1269152 1269958 . - . ID=CDS1;locus_tag=Rv1142c;product=Probable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 1270062 1271144 . + . ID=CDS1;locus_tag=Rv1143;product=Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase );note=FunctionalCategory: lipid metabolism chr1 CDS 1271156 1271908 . + . ID=CDS1;locus_tag=Rv1144;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1272423 1273334 . + . ID=CDS1;locus_tag=Rv1145;product=Probable conserved transmembrane transport protein MmpL13a;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1273355 1274767 . + . ID=CDS1;locus_tag=Rv1146;product=Probable conserved transmembrane transport protein MmpL13b;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1274900 1275550 . + . ID=CDS1;locus_tag=Rv1147;product=Conserved protein/putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 4pneA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pneA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4pneA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pneA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 4pneA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pneA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 4pneA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pneA chr1 CDS 1276300 1277748 . - . ID=CDS1;locus_tag=Rv1148c;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages, Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 22528497] chr1 CDS 1277893 1278300 . + . ID=CDS1;locus_tag=Rv1149;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1278269 1278820 . + . ID=CDS1;locus_tag=Rv1150;product=Possible transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1278904 1279617 . - . ID=CDS1;locus_tag=Rv1151c;product=NAD-dependent protein deacetylase/Transcriptional regulatory protein/NAD-dependent protein deacetylase/Transcriptional regulatory protein;Experiment=DESCRIPTION:Recombinant purification and expression in E.coli, kinase and deacetylase assays, mass spectrometry, western blot [PMID: 27242704],Experiment=DESCRIPTION:Purification and overexpression, HPLC, mass spectrometry, steady-state kinetic assays [PMID: 21627103],Experiment=DESCRIPTION:Purification and expression, enzymatic activity assays [PMID: 19747094],Experiment=DESCRIPTION:Purification and expression, gene knockout, iron and pH-dependent growth assays [PMID: 27566542]/note:FunctionalCategory: regulatory proteins/note:Phosphorylated by PknA and PknB leading to inactivation of transacetylation [PMID: 27242704]/note:Thr-214 implicated as predominant phosphorylation site [PMID: 27242704]/note:Absolute requirement of NAD+ [PMID: 21627103]/note:Regulates acetyl-CoA synthetase activity through deacetylation [PMID: 21627103]/note:Forms a reversible post-translational acetylation system with Rv0998 that regulates siderophore biosynthesis [PMID: 27566542]/note:Modulates iron chelation in iron-limited, low pH condition in M. smegmatis [PMID: 27566542];EC_number=3.5.1.-,EC_number=3.5.1.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:1j8fA,1s7gA,2h59A,2b4yC,1s5pA,3k35F,3gluA,1q17C,2hjhA,4i5iA,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016233/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA,Ontology_term=0006476/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2h59A,2hjhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2h59A,2hjhA,Ontology_term=0000781/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1j8fA,3gluA,1q17C,2hjhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j8fA,3gluA,1q17C,2hjhA,Ontology_term=0036049/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,3jwpA,1iciA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA,Ontology_term=0036047/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,3jwpA,1iciA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2h59A,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2h59A,3jwpA,1iciA,Ontology_term=0005730/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA,Ontology_term=0006342/note:identified by similarity of predicted tertiary structure to PDB 2hjhA,3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hjhA,3jwpA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA,Ontology_term=0005677/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA,Ontology_term=0051287/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2h59A,2hjhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2h59A,2hjhA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2h59A,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2h59A,3jwpA,1iciA,Ontology_term=0005694/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2h59A,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2h59A,3jwpA,1iciA,Ontology_term=0070403/note:identified by similarity of predicted tertiary structure to PDB 1j8fA,1s7gA,2h59A,2b4yC,1s5pA,3k35F,3gluA,1q17C,2hjhA,4i5iA,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j8fA,1s7gA,2h59A,2b4yC,1s5pA,3k35F,3gluA,1q17C,2hjhA,4i5iA,3jwpA,1iciA,Ontology_term=0017136/note:identified by similarity of predicted tertiary structure to PDB 1j8fA,3gluA,1q17C,2hjhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1j8fA,3gluA,1q17C,2hjhA,Ontology_term=0036054/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2b4yC,1s5pA,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2b4yC,1s5pA,3jwpA,1iciA,Ontology_term=0036055/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2b4yC,1s5pA,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2b4yC,1s5pA,3jwpA,1iciA,Ontology_term=0016811/note:identified by similarity of predicted tertiary structure to PDB 2hjhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hjhA,Ontology_term=0034979/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2h59A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2h59A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,2hjhA,3jwpA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,2hjhA,3jwpA,1iciA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1s7gA,1iciA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1s7gA,1iciA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3jwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jwpA chr1 CDS 1279655 1280020 . + . ID=CDS1;locus_tag=Rv1152;product=GntR family transcriptional regulator;Experiment=DESCRIPTION:Gene overexpression, western blot, gene deletion, gene complementation, in vitro growth assay, MIC determination, RT-PCR [PMID: 27349953]/note:negatively regulates expression of vancomycin responsive genes, gene deletion increases susceptibility to vancomycin [PMID: 27349953]/note:FunctionalCategory: regulatory proteins chr1 CDS 1279998 1280846 . - . ID=CDS1;locus_tag=Rv1153c;product=Probable O-methyltransferase Omt;note=FunctionalCategory: lipid metabolism chr1 CDS 1280843 1281484 . - . ID=CDS1;locus_tag=Rv1154c;product=hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1281429 1281872 . + . ID=CDS1;locus_tag=Rv1155;product=Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1282306 1282893 . + . ID=CDS1;locus_tag=Rv1156;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1283056 1284171 . - . ID=CDS1;locus_tag=Rv1157c;product=Conserved ala-, pro-rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1284179 1284862 . - . ID=CDS1;locus_tag=Rv1158c;product=Conserved hypothetical ala-, pro-rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1284992 1286287 . + . ID=CDS1;locus_tag=Rv1159;product=Mannosyltransferase PimE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1286284 1286568 . - . ID=CDS1;locus_tag=Rv1159A;product=Unknown protein/Putative 4a-hydroxytetrahydrobiopterin dehydratase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.2.1.96 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2v6uA,2ebbA,3jstA,1f93A,1ru0A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0051291/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0043496/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0003713/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 2v6uA,2ebbA,3jstA,1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2v6uA,2ebbA,3jstA,1f93A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0006729/note:identified by similarity of predicted tertiary structure to PDB 2v6uA,2ebbA,3jstA,1f93A,1ru0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2v6uA,2ebbA,3jstA,1f93A,1ru0A,Ontology_term=0045893/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0008124/note:identified by similarity of predicted tertiary structure to PDB 2v6uA,2ebbA,3jstA,1f93A,1ru0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2v6uA,2ebbA,3jstA,1f93A,1ru0A,Ontology_term=0004505/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A,Ontology_term=0006558/note:identified by similarity of predicted tertiary structure to PDB 1f93A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f93A chr1 CDS 1286595 1287020 . + . ID=CDS1;locus_tag=Rv1160;product=Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase);note=FunctionalCategory: information pathways chr1 CDS 1287328 1291026 . + . ID=CDS1;locus_tag=Rv1161;product=Respiratory nitrate reductase (alpha chain) NarG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1291065 1292741 . + . ID=CDS1;locus_tag=Rv1162;product=Probable respiratory nitrate reductase (beta chain) NarH;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1292798 1293403 . + . ID=CDS1;locus_tag=Rv1163;product=Probable respiratory nitrate reductase (delta chain) NarJ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1293406 1294146 . + . ID=CDS1;locus_tag=Rv1164;product=Probable respiratory nitrate reductase (gamma chain) NarI;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1294168 1296054 . + . ID=CDS1;locus_tag=Rv1165;product=Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein);note=FunctionalCategory: information pathways chr1 CDS 1296152 1298059 . + . ID=CDS1;locus_tag=Rv1166;product=Probable conserved lipoprotein LpqW;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1298087 1298692 . - . ID=CDS1;locus_tag=Rv1167c;product=Probable transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zb9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zb9A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zb9A,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zb9A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zb9A,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zb9A chr1 CDS 1298764 1299804 . - . ID=CDS1;locus_tag=Rv1168c;gene=PPE17;product=T-cell Antigen;Experiment=DESCRIPTION:Protein expression and purification, enzyme immunoassay, cytokine assay [PMID: 18400969]/note:FunctionalCategory: PE/PPE/note:Interacts with TLR2 to activate NF-kB leading to HIV-1 LTR trans-activation [PMID: 22427668]/note:Displays higher sensitivity in detecting extrapulmonary and smear negative pulmonary TB cases [PMID: 26364913] chr1 CDS 1299822 1300124 . - . ID=CDS1;locus_tag=Rv1169c;gene=PE11/LipX;product=Cell wall associated esterase;Experiment=DESCRIPTION:Recombinant protein purification and expression in M. smegmatis, qRT-PCR for cytokine, Enzyme activity assay using esters of p-nitrophenol (pNP), Transmission electron microscopy, canning electron microscopy, Assay for pellicle and biofilm formation, Measurement of sensitivity to SDS, lysozyme hydrogen peroxide, low pH and antibiotics, Lipid extraction and TLC analysis, GLC and GC/MS of fatty acid composition, mouse infection [PMID: 26902658],Experiment=DESCRIPTION:gene knockdown (RNAi), Scanning electron microscopy, in vitro growth kinetics of recombinant Mtb strains, pellicle and biofilm formation assay, qRT-PCR, lipid extraction and analysis, THP-1 macrophage infection, intracellular survivability assay [PMID: 28198348]/note:FunctionalCategory: PE/PPE/note:enhances biofilm growth of Mycobacterium tuberculosis [PMID: 26902658,28198348]/note:down-regulation of this protein results in up-regulation of the expression of Rv1759c [PMID: 26902658,28198348]/note:confers a growth advantage to M. smegmatis in mouse model [PMID: 26902658]/note:leads to an increased deposition of glycolipids in the cell wall [PMID: 26902658]/note:more resistant to cell wall stress [PMID: 26902658]/note:alters colony morphology, cells expressing PE11 were found to be significantly wider than those not expressing it [PMID: 26902658]/note:increases hydrophobicity of the cell envelope [PMID: 26902658]/note:reduces cell wall virulence lipid levels [PMID: 26902658, 28198348] chr1 CDS 1300304 1301215 . + . ID=CDS1;locus_tag=Rv1170;product=N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1301307 1301747 . + . ID=CDS1;locus_tag=Rv1171;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Potential homology with portions of nitric oxide reductases, identified by similarity of predicted tertiary structure to PDB 4xydA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4xydA chr1 CDS 1301755 1302681 . - . ID=CDS1;locus_tag=Rv1172c;gene=PE12;product=PE family protein PE12;Experiment=EXISTENCE:Gel electrophoresis, liquid chromatography mass spectrometry [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:Located in the cell membrane [PMID: 21920479],Experiment=ally [PMID: 21920479] chr1 CDS 1302931 1305501 . + . ID=CDS1;locus_tag=Rv1173;product=Probable F420 biosynthesis protein FbiC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1305669 1306001 . - . ID=CDS1;locus_tag=Rv1174c;product=Low molecular weight T-cell antigen TB8.4;Experiment=DESCRIPTION:LC-MS/MS [PMID: 17443846]/note:FunctionalCategory: cell wall and cell processes chr1 CDS 1306202 1308226 . - . ID=CDS1;locus_tag=Rv1175c;product=Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase);note=FunctionalCategory: lipid metabolism chr1 CDS 1308223 1308792 . - . ID=CDS1;locus_tag=Rv1176c;product=putative transcriptional regulator;note=FunctionalCategory: conserved hypotheticals, identified by similarity of predicted tertiary structure to PDB 3l9fA,1yg2A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l9fA,1yg2A chr1 CDS 1309005 1309331 . + . ID=CDS1;locus_tag=Rv1177;product=Probable ferredoxin FdxC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1309364 1310452 . + . ID=CDS1;locus_tag=Rv1178;product=Probable aminotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1310480 1313299 . - . ID=CDS1;locus_tag=Rv1179c;product=unknown protein;note=FunctionalCategory: conserved hypotheticals, possible RM-systerm DNA methyltransferase, identified by similarity of predicted tertiary structure to PDB 4xqkA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4xqkA chr1 CDS 1313725 1315191 . + . ID=CDS1;locus_tag=Rv1180;product=Probable polyketide beta-ketoacyl synthase Pks3;note=FunctionalCategory: lipid metabolism chr1 CDS 1315234 1319982 . + . ID=CDS1;locus_tag=Rv1181;product=Probable polyketide beta-ketoacyl synthase Pks4;note=FunctionalCategory: lipid metabolism chr1 CDS 1320035 1321453 . + . ID=CDS1;locus_tag=Rv1182;product=Probable conserved polyketide synthase associated protein PapA3;note=FunctionalCategory: lipid metabolism chr1 CDS 1321520 1324528 . + . ID=CDS1;locus_tag=Rv1183;product=Probable conserved transmembrane transport protein MmpL10;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1324532 1325611 . - . ID=CDS1;locus_tag=Rv1184c;gene=chp2;product=mycoacyltransferase;Experiment=DESCRIPTION:Gene knockout and complementation, lipid extraction and mass spectrometry, subcellular localization and immunoblot, enzyme activity assay [PMID: 25331437],Experiment=DESCRIPTION:Gene knockout and complementation, mass spectrometry, MALDI-TOF/MS/MS, TLC [PMID: 25124040]/note:FunctionalCategory: cell wall and cell processes/note:Cutinase-like hydrolase protein 2 (Chp2)/note:Inhibited by a lipase inhibitor tetrahydrolipstatin [PMID: 25331437]/note:Substrate specificity for native methyl-branched substrates [PMID: 25331437]/note:Not responsible for translocation of diacyltrehaloses to cell surface [PMID: 25124040]/note:Synthesizes penta-acyltrehaloses from diacyltrehaloses through three successive transesterifications of mycosanoyl, mycolipenoyl, and/or mycolipanolyl chains [PMID: 25124040];EC_number=2.3.1.- chr1 CDS 1325776 1327512 . - . ID=CDS1;locus_tag=Rv1185c;product=Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1327689 1329305 . - . ID=CDS1;locus_tag=Rv1186c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1329390 1331021 . + . ID=CDS1;locus_tag=Rv1187;product=Probable pyrroline-5-carboxylate dehydrogenase RocA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1331021 1332010 . + . ID=CDS1;locus_tag=Rv1188;product=Probable proline dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1332092 1332964 . + . ID=CDS1;locus_tag=Rv1189;product=Possible alternative RNA polymerase sigma factor SigI;note=FunctionalCategory: information pathways chr1 CDS 1332980 1333858 . + . ID=CDS1;locus_tag=Rv1190;product=putative C-halide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.8.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3wi7A,2qvbB,1mj5A,4brzA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 1333931 1334845 . + . ID=CDS1;locus_tag=Rv1191;product=esterase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:protein purification and characterization, enzyme activity assay [PMID: 27050490]/inference:ab initio prediction:3D structure prediction using YASARA and PROCHECK, in silico docking studies [PMID: 27050490];EC_number=3.1.-.-,EC_number=2.3.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA,Ontology_term=0016747/note:identified by similarity of predicted tertiary structure to PDB 5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA,Ontology_term=0004414/note:identified by similarity of predicted tertiary structure to PDB 5d6oA,2pl5A,3vvlA,2b61A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d6oA,2pl5A,3vvlA,2b61A,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 2vatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vatA,Ontology_term=0033813/note:identified by similarity of predicted tertiary structure to PDB 2vatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vatA,Ontology_term=0009086/note:identified by similarity of predicted tertiary structure to PDB 2pl5A,2b61A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pl5A,2b61A,Ontology_term=0009001/note:identified by similarity of predicted tertiary structure to PDB 3vvlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vvlA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA,Ontology_term=0009092/note:identified by similarity of predicted tertiary structure to PDB 2pl5A,2b61A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pl5A,2b61A,Ontology_term=0008652/note:identified by similarity of predicted tertiary structure to PDB 5e4yA,5d6oA,2pl5A,3vvlA,2b61A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e4yA,5d6oA,2pl5A,3vvlA,2b61A,Ontology_term=0009058/note:identified by similarity of predicted tertiary structure to PDB 5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e4yA,5d6oA,2pl5A,3vvlA,2b61A,2vatA chr1 CDS 1334939 1335754 . + . ID=CDS1;locus_tag=Rv1192;product=probable protease;Experiment=DESCRIPTION:recombinant DNA expression, beta-casein enzymatic assay, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals/note:part of PGAP 1 family,Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.4.-.-,EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2vtvA,1lbtA,1k8qA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 1lbtA,1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lbtA,1k8qA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2vtvA,1lbtA,1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vtvA,1lbtA,1k8qA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 1lbtA,1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lbtA,1k8qA,Ontology_term=0016788/note:identified by similarity of predicted tertiary structure to PDB 1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,Ontology_term=0004806/note:identified by similarity of predicted tertiary structure to PDB 1lbtA,1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lbtA,1k8qA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA chr1 CDS 1335794 1337215 . + . ID=CDS1;locus_tag=Rv1193;product=Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1337248 1338513 . - . ID=CDS1;locus_tag=Rv1194c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1339003 1339302 . + . ID=CDS1;locus_tag=Rv1195;gene=PE13;product=PE family protein PE13;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:Involved in the interaction between Mycobacterium and host-signaling through the p38-ERK-NF-kB axis and apoptotic pathways [PMID: 27147522]/note:Found in whole-cell lysate, but absent in culture filtrate, and membrane fraction [PMID: 21920479],Experiment=ally [PMID: 21920479]/note:increases the production of interleukin-6 (IL-6) and IL-1β from macrophages, decreases the secretion of suppressor of cytokine signaling 3 (SOCS3), increased the survival of M. smegmatis trains in diamide induced stress [PMID: 27147522] chr1 CDS 1339349 1340524 . + . ID=CDS1;locus_tag=Rv1196;gene=PPE18ormtb39a;product=Surfaced-exposed antigen;Experiment=DESCRIPTION:Protein expression and purification, cell culture, western blotting, immunoprecipitation assay [PMID: 22427668],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Binds the TLR-2 receptor [PMID: 22427668]/note:Stimulates macrophagal secretion of IL-10 cytokines [PMID: 21527209]/note:Elicits an anti-TH1 response [PMID: 21527209]/note:Likely regulated by Rv0485 [PMID: 21527209]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 1340659 1340955 . + . ID=CDS1;locus_tag=Rv1197;product=ESAT-6 like protein EsxK (ESAT-6 like protein 3);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1341006 1341290 . + . ID=CDS1;locus_tag=Rv1198;product=Putative ESAT-6 like protein EsxL (ESAT-6 like protein 4);note=FunctionalCategory: cell wall and cell processes, suppresses anti-mycobacterial defense mechanisms of macrophages by inhibiting the expression of CIITA and subsequently MHC-II molecule [PMID: 28209712] chr1 CDS 1341358 1342605 . - . ID=CDS1;locus_tag=Rv1199c;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1342942 1344219 . + . ID=CDS1;locus_tag=Rv1200;product=Probable conserved integral membrane transport protein/putative transport protein;note=FunctionalCategory: cell wall and cell processes;Ontology_term=0005215/note:identified by similarity of predicted tertiary structure to PDB 4j05A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4j05A,Ontology_term=0022857/note:identified by similarity of predicted tertiary structure to PDB 4j05A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4j05A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4j05A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4j05A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4j05A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4j05A,Ontology_term=0055085/note:identified by similarity of predicted tertiary structure to PDB 4j05A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4j05A chr1 CDS 1344216 1345169 . - . ID=CDS1;locus_tag=Rv1201c;product=Tetrahydrodipicolinate N-succinyltransferase DapD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1345260 1346324 . + . ID=CDS1;locus_tag=Rv1202;product=Probable succinyl-diaminopimelate desuccinylase DapE;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1346321 1346905 . - . ID=CDS1;locus_tag=Rv1203c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1346936 1348624 . - . ID=CDS1;locus_tag=Rv1204c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, possible host-mimickry protein, similar to eukaryotic anaphase-promoting complex subunit, identified by similarity of predicted tertiary structure to PDB 4ui9O;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ui9O chr1 CDS 1348719 1349282 . + . ID=CDS1;locus_tag=Rv1205;product=riboside monophosphate phosphoribohydrolase;Experiment=DESCRIPTION:genetic disruption, HPLC-based activity assay [PMID: 25728768]/inference:similar to AA sequence:RefSeq:NP_565668.1. NM_128389.2/note:proteasome, cytokinin synthesis and secretion/note:FunctionalCategory: conserved hypotheticals/note:pupylated (Pup) proteasome substrate;EC_number=3.2.2.4,EC_number=3.2.2.n1 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2q4oA,2q4dA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA,Ontology_term=0009691/note:identified by similarity of predicted tertiary structure to PDB 2q4oA,2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4oA,2q4dA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2q4oA,2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4oA,2q4dA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2q4oA,2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4oA,2q4dA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2q4oA,2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4oA,2q4dA chr1 CDS 1349332 1351125 . + . ID=CDS1;locus_tag=Rv1206;product=Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1351191 1352147 . + . ID=CDS1;locus_tag=Rv1207;product=Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1352144 1353118 . + . ID=CDS1;locus_tag=Rv1208;product=Probable glucosyl-3-phosphoglycerate synthase GpgS;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1353157 1353525 . + . ID=CDS1;locus_tag=Rv1209;product=Conserved protein;note=putatively involved in Arabinogalactan biosynthesis [PMID: 21573108], FunctionalCategory: conserved hypotheticals chr1 CDS 1353522 1354136 . + . ID=CDS1;locus_tag=Rv1210;product=Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I);note=FunctionalCategory: information pathways chr1 CDS 1354243 1354470 . + . ID=CDS1;locus_tag=Rv1211;product=putative calmodulin-like protein (CAMLP);Experiment=DESCRIPTION:in vitro/in vivo gene expression reduction, expression profile [PMID: 25359006], expression affected by known calmodulin antagonist [PMID: 19639701]/note:FunctionalCategory: conserved hypotheticals/note:contains a calcium-binding EF-hand motif/note:probable regulator of activation of transcriptional regulators or sigma factors/note:phosphorylates and dephosphorylates kinases chr1 CDS 1354498 1355661 . - . ID=CDS1;locus_tag=Rv1212c;product=Putative glycosyl transferase GlgA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1355836 1357050 . + . ID=CDS1;locus_tag=Rv1213;product=Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1357293 1357625 . - . ID=CDS1;locus_tag=Rv1214c;gene=PE14;product=PE family protein PE14;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 1357759 1359444 . - . ID=CDS1;locus_tag=Rv1215c;product=Conserved protein/putative dipeptidyl-peptidase;note=distant similarity to AA sequence: PSI-BLAST [PMID: 25012658], FunctionalCategory: conserved hypotheticals, distant similarity to S-adenosyl methionine-dependent membrane-embedded methyltransferase and lipid esterase/transferase;EC_number=3.4.14.-;Ontology_term=0008239/note:identified by similarity of predicted tertiary structure to PDB 3iiiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iiiA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3iiiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iiiA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3iiiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iiiA chr1 CDS 1359472 1360146 . - . ID=CDS1;locus_tag=Rv1216c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1360155 1361801 . - . ID=CDS1;locus_tag=Rv1217c;product=Probable tetronasin-transport integral membrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1361798 1362733 . - . ID=CDS1;locus_tag=Rv1218c;product=Probable tetronasin-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1362723 1363361 . - . ID=CDS1;locus_tag=Rv1219c;gene=raaS;product=TetR-like transcriptional regulator Raas (regulator of antimicrobial-assisted survival);Experiment=DESCRIPTION:Crystallography, electrophoretic mobility shift assays (EMSA) [PMID: 24424575]/note:represses transcriptional regulation of the Rv1217c-Rv1218c multidrug efflux transport system [PMID: 24424575]/note:interaction with DNA mediated by oleoyl coenzyme A [PMID: 25012658]/note:upregulated during manganese (Mn) deficiency [PMID: 26337157]/note:FunctionalCategory: regulatory proteins chr1 CDS 1363503 1364150 . - . ID=CDS1;locus_tag=Rv1220c;product=Probable methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1364413 1365186 . + . ID=CDS1;locus_tag=Rv1221;product=Alternative RNA polymerase sigma factor SigE;note=FunctionalCategory: information pathways chr1 CDS 1365344 1365808 . + . ID=CDS1;locus_tag=Rv1222;product=Anti-sigma factor RseA;note=FunctionalCategory: information pathways chr1 CDS 1365875 1367461 . + . ID=CDS1;locus_tag=Rv1223;product=Probable serine protease HtrA (DEGP protein);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1367463 1367858 . + . ID=CDS1;locus_tag=Rv1224;gene=tatB;product=Probable protein TatB;Experiment=DESCRIPTION:Gene knockout and complementation in M. smegmatis, beta-lactamase export assay in M. smegmatis [PMID: 16267291],Experiment=DESCRIPTION:Gene knockout and complementation in M. smegmatis, TorA-GFP secretion assay in M. smegmatis [PMID: 16452415]/note:FunctionalCategory: cell wall and cell processes/note:Twin arginine translocation pathway [PMID: 16267291,16452415]/note:Possibly involved in sigE regulation [PMID: 16267291]/note:Described as nonessential by traSH analysis [PMID: 12657046]/note:Failure to secrete BlaS confers ampicillin susceptibility upon strains with tatB mutations [PMID: 16452415] chr1 CDS 1367891 1368721 . - . ID=CDS1;locus_tag=Rv1225c;product=putative acid anhydride phophatase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2x4dA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008969/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0016791/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0016311/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0016607/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0009168/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0004427/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0006470/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA,Ontology_term=0006796/note:identified by similarity of predicted tertiary structure to PDB 2x4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x4dA chr1 CDS 1368832 1370295 . - . ID=CDS1;locus_tag=Rv1226c;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1370292 1370825 . - . ID=CDS1;locus_tag=Rv1227c;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1370920 1371477 . + . ID=CDS1;locus_tag=Rv1228;product=Probable lipoprotein LpqX;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1371777 1372949 . - . ID=CDS1;locus_tag=Rv1229c;product=Probable Mrp-related protein Mrp;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1372962 1374197 . - . ID=CDS1;locus_tag=Rv1230c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes, Promoter region displays a binding affinity with HupB [PMID: 24816602] chr1 CDS 1374322 1374864 . - . ID=CDS1;locus_tag=Rv1231c;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1374861 1376168 . - . ID=CDS1;locus_tag=Rv1232c;gene=MgtE;product=putative magnesium transporter;Inference=ab initio prediction:Phyre2 [PMID: 23287603]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 1376230 1376826 . - . ID=CDS1;locus_tag=Rv1233c;product=Conserved hypothetical membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1376976 1377503 . + . ID=CDS1;locus_tag=Rv1234;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1377524 1378930 . + . ID=CDS1;locus_tag=Rv1235;product=Probable sugar-binding lipoprotein LpqY;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1378927 1379850 . + . ID=CDS1;locus_tag=Rv1236;product=Probable sugar-transport integral membrane protein ABC transporter SugA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1379855 1380679 . + . ID=CDS1;locus_tag=Rv1237;product=Probable sugar-transport integral membrane protein ABC transporter SugB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1380684 1381865 . + . ID=CDS1;locus_tag=Rv1238;product=Probable sugar-transport ATP-binding protein ABC transporter SugC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1381942 1383042 . - . ID=CDS1;locus_tag=Rv1239c;product=Possible magnesium and cobalt transport transmembrane protein CorA;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1383213 1384202 . + . ID=CDS1;locus_tag=Rv1240;product=Probable malate dehydrogenase Mdh;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1384278 1384538 . + . ID=CDS1;locus_tag=Rv1241;product=Possible antitoxin VapB33;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1384535 1384966 . + . ID=CDS1;locus_tag=Rv1242;product=Possible toxin VapC33. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1384989 1386677 . - . ID=CDS1;locus_tag=Rv1243c;gene=PE_PGRS23;product=PE-PGRS family protein PE_PGRS23;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection [PMID: 21085642] chr1 CDS 1386857 1387717 . + . ID=CDS1;locus_tag=Rv1244;product=Probable lipoprotein LpqZ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1387798 1388628 . - . ID=CDS1;locus_tag=Rv1245c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1388685 1388978 . - . ID=CDS1;locus_tag=Rv1246c;product=Toxin RelE;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1388975 1389244 . - . ID=CDS1;locus_tag=Rv1247c;product=Antitoxin RelB;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1389357 1393052 . - . ID=CDS1;locus_tag=Rv1248c;product=Multifunctional alpha-ketoglutarate metabolic enzyme;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1393194 1393982 . - . ID=CDS1;locus_tag=Rv1249c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1394179 1395918 . + . ID=CDS1;locus_tag=Rv1250;product=Probable drug-transport integral membrane protein;note=FunctionalCategory: cell wall and cell processes, Induced by INH (overexpressed on treatment with 1/2MIC of INH as compared to 1/3MIC and i/4MIC of INH) [PMID: 25680943], Belongs to (major facilitator) MFS superfamily [PMID: 25680943], Possible efflux pump gene [PMID: 25680943] chr1 CDS 1395821 1399240 . - . ID=CDS1;locus_tag=Rv1251c;product=putative ester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5eanA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0017108/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0006264/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0006260/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0006284/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0006281/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0004386/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0016890/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0043137/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0043139/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0000784/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0003678/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0043142/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=1902990/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0042645/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0000723/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0000729/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0033567/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0045740/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0032508/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0006974/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0090305/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0043504/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0000076/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA,Ontology_term=0005760/note:identified by similarity of predicted tertiary structure to PDB 5eanA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5eanA chr1 CDS 1399296 1399904 . - . ID=CDS1;locus_tag=Rv1252c;product=Probable lipoprotein LprE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1399970 1401661 . + . ID=CDS1;locus_tag=Rv1253;product=Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog);note=FunctionalCategory: information pathways chr1 CDS 1401658 1402809 . + . ID=CDS1;locus_tag=Rv1254;product=Probable acyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1402778 1403386 . - . ID=CDS1;locus_tag=Rv1255c;product=Probable transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d1wA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d1wA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d1wA,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d1wA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d1wA chr1 CDS 1403386 1404603 . - . ID=CDS1;locus_tag=Rv1256c;product=Probable cytochrome P450 130 Cyp130;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1404717 1406084 . - . ID=CDS1;locus_tag=Rv1257c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1406081 1407340 . - . ID=CDS1;locus_tag=Rv1258c;product=Efflux pump/conserved integral membrane transport protein/Putative transporter;Experiment=DESCRIPTION:In vitro gene disruption, wide-field fluorescence microscopy, macrophage growth and infection [PMID: 21376383]/note:FunctionalCategory: cell wall and cell processes/note:Involved in RIF resistance [PMID: 21376383]/note:Contributes to macrophage growth in vivo [PMID: 21376383]/note:Involved in gentamicin resistance [PMID: 22314527]/note:Involved in spectinomycin resistance [PMID: 22314527]/note:overexpressed due to INH exposure in one isolate [PMID: 18321205]/note:exposure to ofloxacin increased transcription of this gene in a clinical isolate [PMID: 15057575]/note:Rv1258c pump-mediated efflux can be avoided by structural modification of spectinomycin [PMID: 27999020]/note:Belongs to MFS (major facilitator) superfamily [PMID: 22314527]/note:Up regulated in otsB2 mutant strain (trehalose-6-phosphate phosphatase silenced strain) [PMID: 27936238]/note:knockout mutant displays increased susceptibility to killing by lysosomal soluble fraction from activated macrophage and attenuated survival in primary murine macrophage and human macrophage [PMID: 27324481]/note:identified by similarity of predicted tertiary structure to PDB:5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA chr1 CDS 1407339 1408238 . + . ID=CDS1;locus_tag=Rv1259;product=Probable uracil DNA glycosylase, UdgB;note=FunctionalCategory: information pathways chr1 CDS 1408240 1409358 . + . ID=CDS1;locus_tag=Rv1260;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1409484 1409933 . - . ID=CDS1;locus_tag=Rv1261c;product=probable F420-H2-dependent quinone reductase;Experiment=DESCRIPTION:Enzymatic assay, mass spectrometry, allelic exchange gene deficient mutant [PMID: 23240649]/inference:alignment: multiple sequence alignment [PMID: 23240649]/note:FunctionalCategory: conserved hypotheticals;EC_number=,EC_number=1.6.5.2 chr1 CDS 1409938 1410372 . - . ID=CDS1;locus_tag=Rv1262c;product=putative nucleotidyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.7.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0033499/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0008108/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0005794/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0019388/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0003877/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0004335/note:identified by similarity of predicted tertiary structure to PDB 1guqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0046835/note:identified by similarity of predicted tertiary structure to PDB 1guqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,Ontology_term=0006012/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,1guqA,5in3B,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0015967/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,1guqA,5in3B,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0006011/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0008198/note:identified by similarity of predicted tertiary structure to PDB 1guqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 3anoA,1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,1guqA,5in3B,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B,Ontology_term=0008796/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3anoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3anoA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0006258/note:identified by similarity of predicted tertiary structure to PDB 5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5in3B,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1guqA,5in3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1guqA,5in3B chr1 CDS 1410431 1411819 . + . ID=CDS1;locus_tag=Rv1263;product=Probable amidase AmiB2 (aminohydrolase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1411894 1413087 . + . ID=CDS1;locus_tag=Rv1264;product=Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1413260 1413940 . + . ID=CDS1;locus_tag=Rv1265;product=Unknown protein;Experiment=DESCRIPTION:mutagenesis [PMID: 26156642]/note:FunctionalCategory: conserved hypotheticals/note:cAMP induced/note:associated with cell envelope/note:influences macrophagal cytokine profile [PMID: 26156642]/note:up-regulates cell wall fatty acid components chr1 CDS 1413960 1415840 . - . ID=CDS1;locus_tag=Rv1266c;product=Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H);note=FunctionalCategory: regulatory proteins chr1 CDS 1416181 1417347 . - . ID=CDS1;locus_tag=Rv1267c;product=Probable transcriptional regulatory protein EmbR;note=FunctionalCategory: regulatory proteins chr1 CDS 1417658 1418356 . - . ID=CDS1;locus_tag=Rv1268c;product=Hypothetical protein;note=recombinant DNA expression [PMID: 10722636] revealed likely presence of transmembrane domain and possible secretion, FunctionalCategory: conserved hypotheticals chr1 CDS 1418579 1418953 . - . ID=CDS1;locus_tag=Rv1269c;product=Conserved probable secreted protein;note=FunctionalCategory: cell wall and cell processes, Shows alkaline phosphatase activity [PMID: 10722636] chr1 CDS 1419014 1419748 . - . ID=CDS1;locus_tag=Rv1270c;product=Possible lipoprotein LprA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1419961 1420302 . - . ID=CDS1;locus_tag=Rv1271c;product=Conserved hypothetical secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1420410 1422305 . - . ID=CDS1;locus_tag=Rv1272c;product=Probable drugs-transport transmembrane ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1422302 1424050 . - . ID=CDS1;locus_tag=Rv1273c;product=Probable drugs-transport transmembrane ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1424197 1424754 . + . ID=CDS1;locus_tag=Rv1274;product=Possible lipoprotein LprB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1424751 1425293 . + . ID=CDS1;locus_tag=Rv1275;product=Possible lipoprotein LprC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1425438 1425914 . - . ID=CDS1;locus_tag=Rv1276c;product=putative phosphoprotein phosphatase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.3.-;Ontology_term=0005741/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,3e9dA,Ontology_term=0016791/note:identified by similarity of predicted tertiary structure to PDB 2yn2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yn2A,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0016311/note:identified by similarity of predicted tertiary structure to PDB 2yn2A,3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yn2A,3e9dA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=1904813/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0061621/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0030388/note:identified by similarity of predicted tertiary structure to PDB 3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e9dA,Ontology_term=0016868/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A,Ontology_term=0006096/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A,Ontology_term=0006094/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,3gp5A,1yjxA,2hhjA,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,3gp5A,1yjxA,2hhjA,4embA,1xq9A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1yjxA,3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1yjxA,3e9dA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0043209/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e9dA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1yjxA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,3e9dA,Ontology_term=0004082/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0004083/note:identified by similarity of predicted tertiary structure to PDB 3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e9dA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0006110/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0005758/note:identified by similarity of predicted tertiary structure to PDB 1qhfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,Ontology_term=0004619/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA,3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,3e9dA,Ontology_term=0006915/note:identified by similarity of predicted tertiary structure to PDB 3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e9dA,Ontology_term=0006914/note:identified by similarity of predicted tertiary structure to PDB 3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e9dA,Ontology_term=0007585/note:identified by similarity of predicted tertiary structure to PDB 2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hhjA,Ontology_term=0019901/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,3gp5A,1yjxA,1h2fA,3e9dA,2hhjA,3d8hB,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,3gp5A,1yjxA,1h2fA,3e9dA,2hhjA,3d8hB,4embA,1xq9A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,3gp5A,1yjxA,1h2fA,3e9dA,2hhjA,3d8hB,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,3gp5A,1yjxA,1h2fA,3e9dA,2hhjA,3d8hB,4embA,1xq9A,Ontology_term=0034774/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0043456/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,2hhjA,1yjxA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,2hhjA,1yjxA,1xq9A,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hhjA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,3gp5A,3d8hB,2hhjA,1yjxA,4embA,1xq9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,1yjxA,3e9dA,2hhjA,4embA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,1yjxA,3e9dA,2hhjA,4embA,1xq9A,Ontology_term=0043312/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0045730/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0004331/note:identified by similarity of predicted tertiary structure to PDB 3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e9dA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0046538/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1riiA,2hhjA,1yjxA,1xq9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1riiA,2hhjA,1yjxA,1xq9A,Ontology_term=0006003/note:identified by similarity of predicted tertiary structure to PDB 3e9dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e9dA chr1 CDS 1426164 1427417 . + . ID=CDS1;locus_tag=Rv1277;product=Conserved hypothetical protein;note=whole genome expression profiling, microarray analysis [PMID: 12705867], FunctionalCategory: conserved hypotheticals, part of the SbcD family, possible DNA repair exonuclease chr1 CDS 1427414 1430041 . + . ID=CDS1;locus_tag=Rv1278;product=putative transport protein;note=FunctionalCategory: conserved hypotheticals, very strong structural homology to nuclear transport proteins in various eukaryotes, potential RNA-mediated transport receptor, possible host-mimickry protein, identified by similarity of predicted tertiary structure to PDB 4c0oA,2x19B,3m1iC,3icqT,3gjxA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c0oA,2x19B,3m1iC,3icqT,3gjxA chr1 CDS 1430062 1431648 . + . ID=CDS1;locus_tag=Rv1279;product=Probable dehydrogenase FAD flavoprotein GMC oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1431665 1432765 . - . ID=CDS1;locus_tag=Rv1280c;product=Probable periplasmic oligopeptide-binding lipoprotein OppA;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1433433 1435271 . - . ID=CDS1;locus_tag=Rv1281c;product=Probable oligopeptide-transport ATP-binding protein ABC transporter OppD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1435268 1436143 . - . ID=CDS1;locus_tag=Rv1282c;product=Probable oligopeptide-transport integral membrane protein ABC transporter OppC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1436140 1437117 . - . ID=CDS1;locus_tag=Rv1283c;product=Probable oligopeptide-transport integral membrane protein ABC transporter OppB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1437324 1437815 . + . ID=CDS1;locus_tag=Rv1284;product=Beta-carbonic anhydrase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1437978 1438907 . + . ID=CDS1;locus_tag=Rv1285;product=Probable sulfate adenylyltransferase subunit 2 CysD;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1438907 1440751 . + . ID=CDS1;locus_tag=Rv1286;product=Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1440805 1441290 . + . ID=CDS1;locus_tag=Rv1287;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1441348 1442718 . + . ID=CDS1;locus_tag=Rv1288;product=Putative lipolytic enzyme;Inference=ab initio prediction: 3D structure determination, molecular docking simulations [PMID: 27890013]/note:FunctionalCategory: conserved hypotheticals/note:contains a LytE domain [PMID: 27890013];EC_number=3.-.-.- chr1 CDS 1442767 1443399 . + . ID=CDS1;locus_tag=Rv1289;product=Unknown protein;note=Structural prediction and homology PDB: 3cewA [PMID: 26762852], FunctionalCategory: conserved hypotheticals, potential cupin protein chr1 CDS 1443482 1445047 . - . ID=CDS1;locus_tag=Rv1290c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Knockout of this gene results in virulence attenuation [PMID: 12368431] chr1 CDS 1445058 1445372 . + . ID=CDS1;locus_tag=Rv1290A;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1445499 1445834 . - . ID=CDS1;locus_tag=Rv1291c;product=Conserved hypothetical secreted protein;note=FunctionalCategory: cell wall and cell processes, Upregulated in persister cells [PMID: 27176494] chr1 CDS 1446379 1448031 . + . ID=CDS1;locus_tag=Rv1292;product=Probable arginyl-tRNA synthetase ArgS (ARGRS) (arginine--tRNA ligase);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1448028 1449371 . + . ID=CDS1;locus_tag=Rv1293;product=Diaminopimelate decarboxylase LysA (DAP decarboxylase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1449375 1450700 . + . ID=CDS1;locus_tag=Rv1294;product=Probable homoserine dehydrogenase ThrA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1450697 1451779 . + . ID=CDS1;locus_tag=Rv1295;product=Threonine synthase ThrC (ts);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1451997 1452947 . + . ID=CDS1;locus_tag=Rv1296;product=Probable homoserine kinase ThrB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1453204 1455012 . + . ID=CDS1;locus_tag=Rv1297;gene=rho;product=5′→3′-directional, ATP-dependent RNA helicase, transcription termination factor, Rho /5′→3′-directional, ATP-dependent RNA helicase, transcription termination factor, Rho;Experiment=DESCRIPTION:protein purification and expression, electrophoretic mobility shift assay, mass spectrometry, colorimetric assay [PMID: 25229539],Experiment=DESCRIPTION:mutagenesis, ATPase, duplex unwinding, and transcription termination assays [PMID: 25999346]/note:FunctionalCategory: information pathways [PMID: 25229539]/note:Possesses additional N-terminal domain relative to canonical rho that is an RNA-binding domain [PMID: 25229539]/note:The work in [PMID: 25999346] disproved the suggestion in [PMID: 25229539] that Rho in M.tb lacked helicase activity. It appears it does act as a helicase/note:requires a catalytic site that is fully competent for ATP hydrolysis to promote duplex unwinding or transcription termination [PMID: 25999346],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.6.4.13,EC_number=3.6.1.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3l0oA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.6.4.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3iceC/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008186/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iceC,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iceC,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0006353/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iceC,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3iceC,Ontology_term=0003676/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC,Ontology_term=0004386/note:identified by similarity of predicted tertiary structure to PDB 3l0oA,3iceC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l0oA,3iceC chr1 CDS 1455163 1455405 . + . ID=CDS1;locus_tag=Rv1298;product=50S ribosomal protein L31 RpmE;note=FunctionalCategory: information pathways chr1 CDS 1455495 1456568 . + . ID=CDS1;locus_tag=Rv1299;product=Probable peptide chain release factor 1 PrfA (RF-1);note=FunctionalCategory: information pathways chr1 CDS 1456565 1457542 . + . ID=CDS1;locus_tag=Rv1300;product=Probable HemK protein homolog HemK;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1457558 1458211 . + . ID=CDS1;locus_tag=Rv1301;product=Putative L-threonylcarbamoyladenylate synthase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=2.7.7.87 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2eqaA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0061710/note:identified by similarity of predicted tertiary structure to PDB 2eqaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eqaA,Ontology_term=0008270,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2eqaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eqaA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2eqaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eqaA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2eqaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eqaA,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 2eqaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eqaA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 2eqaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eqaA,Ontology_term=0003725/note:identified by similarity of predicted tertiary structure to PDB 2eqaA,3vthA,3tspA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2eqaA,3vthA,3tspA chr1 CDS 1458295 1459509 . + . ID=CDS1;locus_tag=Rv1302;product=Probable undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe (UDP-GlcNAc transferase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 1459766 1460251 . + . ID=CDS1;locus_tag=Rv1303;product=Conserved hypothetical transmembrane protein;note=FunctionalCategory: cell wall and cell processes, Co-transcribed with genes encoding different subunits of ATP synthase (Rv1304 to Rv1312) [PMID: 26786219] chr1 CDS 1460244 1460996 . + . ID=CDS1;locus_tag=Rv1304;product=Probable ATP synthase a chain AtpB (protein 6);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1461045 1461290 . + . ID=CDS1;locus_tag=Rv1305;product=Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1461321 1461836 . + . ID=CDS1;locus_tag=Rv1306;product=Probable ATP synthase B chain AtpF;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1461843 1463183 . + . ID=CDS1;locus_tag=Rv1307;product=Probable ATP synthase delta chain AtpH;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1463228 1464877 . + . ID=CDS1;locus_tag=Rv1308;product=Probable ATP synthase alpha chain AtpA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1464884 1465801 . + . ID=CDS1;locus_tag=Rv1309;product=Probable ATP synthase gamma chain AtpG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1465841 1467301 . + . ID=CDS1;locus_tag=Rv1310;product=Probable ATP synthase beta chain AtpD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1467315 1467680 . + . ID=CDS1;locus_tag=Rv1311;product=Probable ATP synthase epsilon chain AtpC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1467688 1468131 . + . ID=CDS1;locus_tag=Rv1312;product=Conserved hypothetical secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1468171 1469505 . - . ID=CDS1;locus_tag=Rv1313c;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1469671 1470252 . - . ID=CDS1;locus_tag=Rv1314c;product=putative PduO-type ATP co(I)rrinoid adenosyltransferase;Experiment=DESCRIPTION:genome-wide transposon mutagenesis, small number of mutants mapped to Rv1314c [PMID: 23407640]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.5.1.17,EC_number=2.5.1.17 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3ke4A,2idxC,3ci1A,2g2dA,2zhzB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0009236/note:identified by similarity of predicted tertiary structure to PDB 2g2dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g2dA,Ontology_term=0006779/note:identified by similarity of predicted tertiary structure to PDB 2g2dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g2dA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2g2dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g2dA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3ke4A,3ci1A,2g2dA,2zhzB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ke4A,3ci1A,2g2dA,2zhzB,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3ci1A,2g2dA,2zhzB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ci1A,2g2dA,2zhzB,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3ke4A,3ci1A,2g2dA,2zhzB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ke4A,3ci1A,2g2dA,2zhzB,Ontology_term=0008817/note:identified by similarity of predicted tertiary structure to PDB 2g2dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g2dA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3ci1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ci1A chr1 CDS 1470321 1471577 . + . ID=CDS1;locus_tag=Rv1315;product=Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1477134 1477631 . - . ID=CDS1;locus_tag=Rv1316c;product=Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase);note=FunctionalCategory: information pathways chr1 CDS 1477628 1479118 . - . ID=CDS1;locus_tag=Rv1317c;product=Probable bifunctional regulatory protein and DNA repair enzyme AlkA (regulatory protein of adaptive response) (methylphosphotriester-DNA--protein-cysteine S-methyltransferase);note=FunctionalCategory: information pathways chr1 CDS 1479199 1480824 . - . ID=CDS1;locus_tag=Rv1318c;product=Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1480894 1482501 . - . ID=CDS1;locus_tag=Rv1319c;product=Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1482514 1484217 . - . ID=CDS1;locus_tag=Rv1320c;product=Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1484279 1484959 . + . ID=CDS1;locus_tag=Rv1321;product=putative ester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA,Ontology_term=0090305/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2vldA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vldA chr1 CDS 1484982 1485278 . + . ID=CDS1;locus_tag=Rv1322;product=Conserved hypothetical protein;note=microarray expression analysis [PMID: 18253472], Genechip analysis (algorithm analysis, cluster analysis) [PMID: 18253472], FunctionalCategory: conserved hypotheticals, contains a Glyoxalase domain chr1 CDS 1485313 1485771 . - . ID=CDS1;locus_tag=Rv1322A;product=Putative GntR family transcriptional regulator;Experiment=DESCRIPTION:transposon gene disruption [PMID: 15758213]/inference:similar to AA sequence:BLAST [PMID: 15758213]/note:FunctionalCategory: conserved hypotheticals;EC_number=5.1.99.1 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1jc5B,3rmuA/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.4.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3hdpA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004493/note:identified by similarity of predicted tertiary structure to PDB 1jc5B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jc5B,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3hdpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hdpA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3hdpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hdpA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1jc5B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jc5B chr1 CDS 1485862 1487031 . + . ID=CDS1;locus_tag=Rv1323;product=Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase);note=FunctionalCategory: lipid metabolism chr1 CDS 1487161 1488075 . + . ID=CDS1;locus_tag=Rv1324;product=Possible thioredoxin;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1488154 1489965 . - . ID=CDS1;locus_tag=Rv1325c;gene=PE_PGRS24;product=PE-PGRS family protein PE_PGRS24;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642] chr1 CDS 1490117 1491436 . - . ID=CDS1;locus_tag=Rv1326c;product=1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1492320 1494425 . - . ID=CDS1;locus_tag=Rv1327c;product=Probable glucanase GlgE;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1494564 1497155 . + . ID=CDS1;locus_tag=Rv1328;product=Probable glycogen phosphorylase GlgP;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1497195 1499189 . - . ID=CDS1;locus_tag=Rv1329c;product=Probable ATP-dependent helicase DinG;note=FunctionalCategory: information pathways chr1 CDS 1499213 1500559 . - . ID=CDS1;locus_tag=Rv1330c;product=Nicotinic acid phosphoribosyltransferase PncB1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1500661 1500966 . + . ID=CDS1;locus_tag=Rv1331;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1500926 1501582 . + . ID=CDS1;locus_tag=Rv1332;product=Transcriptional regulatory protein;Experiment=DESCRIPTION:ChIP-seq, microarray, Transcription factor overexpression [PMID: 25581030]/note:FunctionalCategory: regulatory proteins chr1 CDS 1501599 1502633 . + . ID=CDS1;locus_tag=Rv1333;product=Probable hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1502641 1503081 . + . ID=CDS1;locus_tag=Rv1334;product=Possible hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1503103 1503384 . + . ID=CDS1;locus_tag=Rv1335;product=Sulfur carrier protein CysO;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1503394 1504365 . + . ID=CDS1;locus_tag=Rv1336;product=Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1504356 1505078 . + . ID=CDS1;locus_tag=Rv1337;product=Probable rhomboid protease/integral membrane protein;Experiment=DESCRIPTION:Mutagenesis, expression testing, western blot, cellular fractionation, copy number determination [PMID: 19165721]/note:FunctionalCategory: cell wall and cell processes/note:Probably involved in biofilm formation [PMID: 23029216]/note:Probably involved in ciprofloxacin and novobiocin resistance [PMID: 23029216];EC_number=3.4.21.105 chr1 CDS 1505075 1505890 . + . ID=CDS1;locus_tag=Rv1338;product=Probable glutamate racemase MurI;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1505917 1506738 . + . ID=CDS1;locus_tag=Rv1339;product=Probable ribonuclease;note=FunctionalCategory: conserved hypotheticals,;EC_number=3.1.26.-;Ontology_term=0090502/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0090503/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0004527/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0004532/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0042781/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0016891/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0042779/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0034414/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2cbnA1,2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA1,2cbnA chr1 CDS 1506755 1507534 . + . ID=CDS1;locus_tag=Rv1340;product=Probable ribonuclease RphA (RNase PH) (tRNA nucleotidyltransferase);note=FunctionalCategory: information pathways chr1 CDS 1507573 1508187 . + . ID=CDS1;locus_tag=Rv1341;product=Probable Nucleotide diphosphatase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.9 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/note:identified by similarity of predicted tertiary structure to PDB 4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA;Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2pyuA,3tquA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pyuA,3tquA,1vp2A,2carA,Ontology_term=0004551/note:identified by similarity of predicted tertiary structure to PDB 2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2carA,Ontology_term=0009143/note:identified by similarity of predicted tertiary structure to PDB 4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA,Ontology_term=0009146/note:identified by similarity of predicted tertiary structure to PDB 2pyuA,2mjpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pyuA,2mjpA,Ontology_term=0006195/note:identified by similarity of predicted tertiary structure to PDB 2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2carA,Ontology_term=0006193/note:identified by similarity of predicted tertiary structure to PDB 2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2carA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA,Ontology_term=0047429/note:identified by similarity of predicted tertiary structure to PDB 4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2mjpA,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2mjpA,2carA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 2pyuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pyuA,Ontology_term=0035870/note:identified by similarity of predicted tertiary structure to PDB 2pyuA,2mjpA,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pyuA,2mjpA,2carA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2carA,Ontology_term=0035529/note:identified by similarity of predicted tertiary structure to PDB 2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2carA,Ontology_term=0036222/note:identified by similarity of predicted tertiary structure to PDB 2pyuA,2mjpA,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pyuA,2mjpA,2carA,Ontology_term=0036220/note:identified by similarity of predicted tertiary structure to PDB 2pyuA,2mjpA,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pyuA,2mjpA,2carA,Ontology_term=0017111/note:identified by similarity of predicted tertiary structure to PDB 4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,Ontology_term=0009117/note:identified by similarity of predicted tertiary structure to PDB 4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bnqA,1v7rA,2pyuA,3tquA,2mjpA,1vp2A,2carA,Ontology_term=0051276/note:identified by similarity of predicted tertiary structure to PDB 2carA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2carA chr1 CDS 1508184 1508546 . - . ID=CDS1;locus_tag=Rv1342c;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1508543 1508923 . - . ID=CDS1;locus_tag=Rv1343c;product=Probable conserved lipoprotein LprD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1508968 1509288 . + . ID=CDS1;locus_tag=Rv1344;product=Acyl carrier protein (ACP) MbtL;note=FunctionalCategory: lipid metabolism chr1 CDS 1509281 1510846 . + . ID=CDS1;locus_tag=Rv1345;product=Probable fatty acyl-AMP ligase MbtM;note=FunctionalCategory: lipid metabolism chr1 CDS 1510846 1512006 . + . ID=CDS1;locus_tag=Rv1346;product=Acyl-CoA dehydrogenase MbtN;note=FunctionalCategory: lipid metabolism chr1 CDS 1511973 1512605 . - . ID=CDS1;locus_tag=Rv1347c;product=Lysine N-acetyltransferase MbtK;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1513047 1515626 . + . ID=CDS1;locus_tag=Rv1348;product=Iron-regulated transporter IrtA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1515623 1517362 . + . ID=CDS1;locus_tag=Rv1349;product=Iron-regulated transporter IrtB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1517491 1518234 . + . ID=CDS1;locus_tag=Rv1350;product=Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase);note=FunctionalCategory: lipid metabolism chr1 CDS 1518231 1518560 . + . ID=CDS1;locus_tag=Rv1351;product=putative outer membrane protein/surface antigen;Experiment=DESCRIPTION:electron capture dissociation mass spectrometry [PMID: 12648932]/inference:similar to AA sequence:orthology, PSI-BLAST, STRING clustering/inference:protein motif:Pfam [PMID: 20466765]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 1518763 1519134 . + . ID=CDS1;locus_tag=Rv1352;product=Conserved protein;Inference=similar to AA sequence:orthology, PSI-BLAST, STRING clustering/inference:protein motif:Pfam [PMID: 20466765]/note:potential outer membrane protein/note:FunctionalCategory: conserved hypotheticals chr1 CDS 1519200 1519985 . - . ID=CDS1;locus_tag=Rv1353c;product=Probable transcriptional regulatory protein/putative transcriptional regulator;note=FunctionalCategory: regulatory proteins, Regulated by InbR [PMID: 26353937];Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2y2zA,2vprA,3zqiA,2o7oA,1bjzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2y2zA,2vprA,3zqiA,2o7oA,1bjzA,Ontology_term=0045892/note:identified by similarity of predicted tertiary structure to PDB 2vprA,3zqiA,2y2zA,2o7oA,1bjzA,3b6aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vprA,3zqiA,2y2zA,2o7oA,1bjzA,3b6aA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2y2zA,2vprA,3zqiA,2o7oA,1bjzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2y2zA,2vprA,3zqiA,2o7oA,1bjzA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2vprA,3zqiA,2y2zA,2o7oA,1bjzA,3b6aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vprA,3zqiA,2y2zA,2o7oA,1bjzA,3b6aA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 3b6aA,2vprA,3zqiA,2o7oA,1bjzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b6aA,2vprA,3zqiA,2o7oA,1bjzA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2vprA,3zqiA,2o7oA,1bjzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vprA,3zqiA,2o7oA,1bjzA chr1 CDS 1520005 1521876 . - . ID=CDS1;locus_tag=Rv1354c;product=bifunctional di-guanylate cyclase/cyclic di-guanylate phosphodiesterase;Experiment=DESCRIPTION:gene knockout/complementation and mutagenesis, purification and expression, enzyme activity assay [PMID: 21151497], protein-protein interaction network using homogeneous mapping method motif: orthology with other protein domain structures, two hybrid assay [PMID: 19298676]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.7.7.65,EC_number=3.1.4.52 chr1 CDS 1521885 1524032 . - . ID=CDS1;locus_tag=Rv1355c;product=Possible molybdopterin biosynthesis protein MoeY;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1524029 1524820 . - . ID=CDS1;locus_tag=Rv1356c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1525293 1526216 . - . ID=CDS1;locus_tag=Rv1357c;product=cyclic diguanylate phosphodiesterase;Experiment=DESCRIPTION:protein purification, enzyme activity assay [PMID: 21151497]/note:degrades c-di-GMP to pGpG/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.4.52,EC_number=2.7.7.65 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4rnfA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.4.52 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4hu3A,4rnfA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 1526612 1530091 . + . ID=CDS1;locus_tag=Rv1358;product=Probable transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins, Contains IS6110 insertion site within the gene [PMID: 26547230], Contains ATPase and helix-turn-helix (HTH) domains [PMID: 21199259], Expression regulated by sigF [PMID: 22307756], Predicted to be pseudogenized in Euro-American lineage [PMID: 26035295] chr1 CDS 1530173 1530925 . + . ID=CDS1;locus_tag=Rv1359;product=Probable transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins, Contains a cyclase domain, annotated as adenylate cyclases but has not yet been shown to be biochemically active, and likely is not since it has mutations at a key metal-cofactor domain and lacks an arginine critical to function in its homologs [PMID: 21199259], Upregulated in starvation and down-regulated in oxidative stress [PMID: 21199259] chr1 CDS 1531348 1532370 . + . ID=CDS1;locus_tag=Rv1360;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1532443 1533633 . - . ID=CDS1;locus_tag=Rv1361c;gene=PPE19;product=PPE family protein PPE19;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 1533948 1534610 . - . ID=CDS1;locus_tag=Rv1362c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1534607 1535332 . - . ID=CDS1;locus_tag=Rv1363c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1535683 1537644 . - . ID=CDS1;locus_tag=Rv1364c;product=Possible sigma factor regulatory protein;note=FunctionalCategory: information pathways chr1 CDS 1537783 1538169 . - . ID=CDS1;locus_tag=Rv1365c;product=Anti-anti-sigma factor RsfA (anti-sigma factor antagonist) (regulator of sigma F A);note=FunctionalCategory: information pathways chr1 CDS 1538390 1539211 . + . ID=CDS1;locus_tag=Rv1366;product=putative diphosphotransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.6.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2be3A,5decA,1vj7A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0015970/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0015969/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0008893/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0016301/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0016310/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0008728/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0042594/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 5decA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5decA chr1 CDS 1539180 1539440 . + . ID=CDS1;locus_tag=Rv1366A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1539512 1540645 . - . ID=CDS1;locus_tag=Rv1367c;product=probable serine hydrolase, Putative Carboxylesterase.;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.-,EC_number=3.5.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,2qmiA,3o3vA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.1.1 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4iviA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008800/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA,Ontology_term=0017001/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 2wzxA,2qz6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wzxA,2qz6A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1zkjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zkjA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3wrtA,1zkjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wrtA,1zkjA,Ontology_term=0033252/note:identified by similarity of predicted tertiary structure to PDB 2wzxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wzxA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,Ontology_term=0030288/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA chr1 CDS 1541020 1541805 . + . ID=CDS1;locus_tag=Rv1368;product=Probable conserved lipoprotein LprF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1541994 1542980 . - . ID=CDS1;locus_tag=Rv1369c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1542929 1543255 . - . ID=CDS1;locus_tag=Rv1370c;product=Putative transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1543359 1544828 . + . ID=CDS1;locus_tag=Rv1371;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes, Down-regulated in absence of pknF promoter [PMID: 23915284], Required for growth in mouse spleen [PMID: 14569030] chr1 CDS 1544825 1546006 . + . ID=CDS1;locus_tag=Rv1372;gene=pks18;product=Alpha-pyrone synthesis polyketide synthase-like Pks18;Experiment=DESCRIPTION:protein purification and characterization[PMID: 12941968]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.3.1.- chr1 CDS 1546012 1546992 . + . ID=CDS1;locus_tag=Rv1373;product=Glycolipid sulfotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1547072 1547530 . - . ID=CDS1;locus_tag=Rv1374c;product=probable small intergenic RNA;Experiment=DESCRIPTION:Northern blot, transcript abundance, ORF orientation analysis [PMID: 22072964]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 1547832 1549151 . + . ID=CDS1;locus_tag=Rv1375;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1549148 1550641 . + . ID=CDS1;locus_tag=Rv1376;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1550579 1551217 . - . ID=CDS1;locus_tag=Rv1377c;product=Putative transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1551228 1552655 . - . ID=CDS1;locus_tag=Rv1378c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1552654 1553235 . + . ID=CDS1;locus_tag=Rv1379;product=Probable pyrimidine operon regulatory protein PyrR;note=FunctionalCategory: regulatory proteins chr1 CDS 1553232 1554191 . + . ID=CDS1;locus_tag=Rv1380;product=Probable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1554188 1555480 . + . ID=CDS1;locus_tag=Rv1381;product=Probable dihydroorotase PyrC (DHOase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1555477 1555974 . + . ID=CDS1;locus_tag=Rv1382;product=Probable export or membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1555971 1557101 . + . ID=CDS1;locus_tag=Rv1383;product=Probable carbamoyl-phosphate synthase small chain CarA (carbamoyl-phosphate synthetase glutamine chain);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1557101 1560448 . + . ID=CDS1;locus_tag=Rv1384;product=Probable carbamoyl-phosphate synthase large chain CarB (carbamoyl-phosphate synthetase ammonia chain);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1560445 1561269 . + . ID=CDS1;locus_tag=Rv1385;product=Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1561464 1561772 . + . ID=CDS1;locus_tag=Rv1386;gene=PE15;product=PE family protein PE15;Experiment=DESCRIPTION:Protein expression and purification, real time polymerase chain reaction, cytokine assay, western blotting [PMID: 23284742],Experiment=EXISTENCE:2-dimensional gel electrophoresis, liquid chromatography mass spectrometry [PMID: 17443846],Experiment=EXISTENCE:Label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:Gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:Probably involved in evading host immune response by altering the Th1 and TH2 type balance via altered MAP Kinase signaling [PMID: 23284742]/note:Associate with the cell envelope [PMID: 23284742]/note:Probably secreted, found expressed in the culture filtrate [PMID: 17443846]/note:Found in whole-cell lysate [PMID: 21920479],Experiment=ally [PMID: 21920479]/note:Found in the cell membrane [PMID: 21261938,21920479] chr1 CDS 1561769 1563388 . + . ID=CDS1;locus_tag=Rv1387;gene=PPE20;product=PPE family protein PPE20;Experiment=EXISTENCE:Label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:Gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:Located in the cell membrane but absent in culture filtrate [PMID: 21920479,21261938] chr1 CDS 1563694 1564266 . + . ID=CDS1;locus_tag=Rv1388;product=Putative integration host factor MihF;note=FunctionalCategory: information pathways chr1 CDS 1564401 1565027 . + . ID=CDS1;locus_tag=Rv1389;product=Probable guanylate kinase Gmk;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1565093 1565425 . + . ID=CDS1;locus_tag=Rv1390;product=Probable DNA-directed RNA polymerase (omega chain) RpoZ (transcriptase omega chain) (RNA polymerase omega subunit);note=FunctionalCategory: information pathways chr1 CDS 1565441 1566697 . + . ID=CDS1;locus_tag=Rv1391;product=Probable DNA/pantothenate metabolism flavoprotein homolog Dfp;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1566825 1568036 . + . ID=CDS1;locus_tag=Rv1392;product=Probable S-adenosylmethionine synthetase MetK (mat) (AdoMet synthetase) (methionine adenosyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1568109 1569587 . - . ID=CDS1;locus_tag=Rv1393c;product=Probable monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1569584 1570969 . - . ID=CDS1;locus_tag=Rv1394c;product=Probable cytochrome P450 132 Cyp132;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1571047 1572081 . + . ID=CDS1;locus_tag=Rv1395;product=Transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins, Upregulated in persistent isolates [PMID: 27176494], Possibly belongs to the AraC/XylS family transcriptional factor [PMID: 25443504], Identified insertion of transposon within ORF of this gene in the strain 2B26 (which was shown to have attenuated growth in vivo in mice lungs) [PMID: 10564470];Ontology_term=0043565/note:identified by similarity of predicted tertiary structure to PDB 5chhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5chhA,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 5chhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5chhA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 5chhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5chhA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 5chhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5chhA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 5chhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5chhA,Ontology_term=0019172/note:identified by similarity of predicted tertiary structure to PDB 5chhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5chhA chr1 CDS 1572127 1573857 . - . ID=CDS1;locus_tag=Rv1396c;gene=PE_PGRS25;product=PE-PGRS family protein PE_PGRS25;note=FunctionalCategory: PE/PPE chr1 CDS 1574112 1574513 . - . ID=CDS1;locus_tag=Rv1397c;product=Possible toxin VapC10;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1574510 1574767 . - . ID=CDS1;locus_tag=Rv1398c;product=Possible antitoxin VapB10;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1574850 1575809 . - . ID=CDS1;locus_tag=Rv1399c;product=Probable non lipolytic carboxylesterase NlhH;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1575834 1576796 . - . ID=CDS1;locus_tag=Rv1400c;product=Probable lipase LipH;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1576930 1577532 . + . ID=CDS1;locus_tag=Rv1401;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1577613 1579580 . + . ID=CDS1;locus_tag=Rv1402;product=Putative primosomal protein N' PriA (replication factor Y);note=FunctionalCategory: information pathways chr1 CDS 1579598 1580422 . - . ID=CDS1;locus_tag=Rv1403c;product=Putative methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1580591 1581073 . + . ID=CDS1;locus_tag=Rv1404;product=MarR family transcription factor;Experiment=DESCRIPTION:Gene knockout and complementation, in vitro ChIP-qPCR, Electromobility band shift assays, protein expression and purification [PMID: 26615221]/note:FunctionalCategory: regulatory proteins/note:Regulates Rv1403c, Rv1405c, Rv1706c, Rv0195, and Rv2390c in vitro [PMID: 26615221]/note:Expression is induced on treatment with thioridazine (candidate for treatment of MDR- and XDR-TB) [PMID: 20386700] chr1 CDS 1581145 1581969 . - . ID=CDS1;locus_tag=Rv1405c;product=Putative methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1582166 1583104 . + . ID=CDS1;locus_tag=Rv1406;product=Probable methionyl-tRNA formyltransferase Fmt;note=FunctionalCategory: information pathways chr1 CDS 1583101 1584474 . + . ID=CDS1;locus_tag=Rv1407;product=Probable Fmu protein (sun protein);note=FunctionalCategory: information pathways chr1 CDS 1584499 1585197 . + . ID=CDS1;locus_tag=Rv1408;product=Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1585194 1586213 . + . ID=CDS1;locus_tag=Rv1409;product=Probable bifunctional riboflavin biosynthesis protein RibG : diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1586210 1587766 . - . ID=CDS1;locus_tag=Rv1410c;product=Aminoglycosides/tetracycline-transport integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1587772 1588482 . - . ID=CDS1;locus_tag=Rv1411c;product=Conserved lipoprotein LprG;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1588567 1589172 . + . ID=CDS1;locus_tag=Rv1412;product=Probable riboflavin synthase alpha chain RibC (RibE);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1589386 1589901 . + . ID=CDS1;locus_tag=Rv1413;product=Putative Threo-3-hydroxy-D-aspartate ammonia-lyase;Experiment=DESCRIPTION:electron capture dissociation by mass spectrometry [PMID: 12648932]/note:putative Cell wall/cell processes/metabolism/note:FunctionalCategory: conserved hypotheticals;EC_number=4.3.1.27 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3wqcA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0030170/note:identified by similarity of predicted tertiary structure to PDB 3wqcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wqcA,Ontology_term=0016841/note:identified by similarity of predicted tertiary structure to PDB 3wqcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wqcA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3wqcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wqcA chr1 CDS 1589891 1590292 . + . ID=CDS1;locus_tag=Rv1414;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1590397 1591674 . + . ID=CDS1;locus_tag=Rv1415;product=Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1591671 1592153 . + . ID=CDS1;locus_tag=Rv1416;product=Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1592150 1592614 . + . ID=CDS1;locus_tag=Rv1417;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes, Interacts with the terminal regions of Erp in the cell envelope [PMID: 19159459], Possibly involved in riboflavin metabolism [PMID: 19159459] chr1 CDS 1592639 1593325 . + . ID=CDS1;locus_tag=Rv1418;product=Probable lipoprotein LprH;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1593505 1593978 . + . ID=CDS1;locus_tag=Rv1419;product=probable lectin/putative glycosidase;Experiment=DESCRIPTION:protein purification and expression in E. coli, crystallization, X-ray crystallography [PMID: 21139219]/note:FunctionalCategory: conserved hypotheticals/note:has a beta-trefoil lectin domain;EC_number=3.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3a23A,1isyA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0052692/note:identified by similarity of predicted tertiary structure to PDB 3a23A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A,Ontology_term=0031176/note:identified by similarity of predicted tertiary structure to PDB 1isyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1isyA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3a23A,1isyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A,1isyA,Ontology_term=0004553/note:identified by similarity of predicted tertiary structure to PDB 3a23A,1isyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A,1isyA,Ontology_term=0016798/note:identified by similarity of predicted tertiary structure to PDB 3a23A,1isyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A,1isyA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3a23A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3a23A,1isyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A,1isyA,Ontology_term=0000272/note:identified by similarity of predicted tertiary structure to PDB 1isyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1isyA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3a23A,1isyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A,1isyA,Ontology_term=0004557/note:identified by similarity of predicted tertiary structure to PDB 3a23A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a23A chr1 CDS 1594042 1595982 . + . ID=CDS1;locus_tag=Rv1420;product=Probable excinuclease ABC (subunit C - nuclease) UvrC;note=FunctionalCategory: information pathways chr1 CDS 1595979 1596884 . + . ID=CDS1;locus_tag=Rv1421;product=conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1596881 1597909 . + . ID=CDS1;locus_tag=Rv1422;product=conserved protein;Experiment=DESCRIPTION:in vitro kinase assays, in vivo recombinant DNA overexpression and depletion [PMID: 15985609], expression and growth assay, deletion and transposon mutagenesis [PMID: 25047842]/note:FunctionalCategory: conserved hypotheticals/note:substrate of PknB and PknA/note:ΔRv1422 strain is markedly attenuated for virulence in a mouse infection model/note:localizes uniquely to the growing cell pole chr1 CDS 1597906 1598883 . + . ID=CDS1;locus_tag=Rv1423;product=Probable transcriptional regulatory protein WhiA;note=FunctionalCategory: regulatory proteins chr1 CDS 1598893 1599654 . - . ID=CDS1;locus_tag=Rv1424c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1599658 1601037 . + . ID=CDS1;locus_tag=Rv1425;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 1601059 1602321 . - . ID=CDS1;locus_tag=Rv1426c;product=Probable esterase LipO;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1602321 1603928 . - . ID=CDS1;locus_tag=Rv1427c;product=Possible long-chain-fatty-acid--CoA ligase FadD12 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1603932 1604759 . - . ID=CDS1;locus_tag=Rv1428c;product=conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1604878 1606146 . + . ID=CDS1;locus_tag=Rv1429;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1606386 1607972 . + . ID=CDS1;locus_tag=Rv1430;gene=PE16;product=Esterase;Experiment=DESCRIPTION:Protein cloning, expression and purification, western blotting, enzymatic assay [PMID: 23383323]/note:FunctionalCategory: PE/PPE/note:Belongs to serine hydrolase superfamily [PMID: 23383323];EC_number=3.1.-.- chr1 CDS 1608083 1609852 . + . ID=CDS1;locus_tag=Rv1431;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1609849 1611270 . + . ID=CDS1;locus_tag=Rv1432;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1611434 1612249 . + . ID=CDS1;locus_tag=Rv1433;product=Probable l,d-transpeptidase LdtMt3;Experiment=DESCRIPTION:Protein purification, enzyme inactivation by carbapenems, mass spectrometry, in vitro cross-linking activity, kinetics of enzyme acylation via spectrofluorometry [PMID: 24041897]/note:FunctionalCategory: cell wall and cell processes/note:Inactivated by carbapenems [PMID: 24041897];EC_number=2.3.2.-,EC_number=2.3.2.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3turA,3vaeA,4jmnA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0018104/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0009252/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3turA,3vaeA,4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3turA,3vaeA,4jmnA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0008360/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0071972/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 4jmnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jmnA chr1 CDS 1612256 1612393 . + . ID=CDS1;locus_tag=Rv1434;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1612342 1612950 . - . ID=CDS1;locus_tag=Rv1435c;product=Probable conserved proline, glycine, valine-rich secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1613307 1614326 . + . ID=CDS1;locus_tag=Rv1436;product=Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1614329 1615567 . + . ID=CDS1;locus_tag=Rv1437;product=Probable phosphoglycerate kinase Pgk;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1615564 1616349 . + . ID=CDS1;locus_tag=Rv1438;product=Probable triosephosphate isomerase Tpi (TIM);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1616961 1617386 . - . ID=CDS1;locus_tag=Rv1439c;product=Unknown protein/putative ether hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.3.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bngC,1nu3B,5aifA,5aihA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004301/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0018744/note:identified by similarity of predicted tertiary structure to PDB 1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nu3B,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bngC,1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,1nu3B,Ontology_term=0033963/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0097176/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC chr1 CDS 1617837 1618070 . + . ID=CDS1;locus_tag=Rv1440;product=Probable protein-export membrane protein (translocase subunit) SecG;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1618209 1619684 . - . ID=CDS1;locus_tag=Rv1441c;gene=PE_PGRS26;product=PE-PGRS family protein PE_PGRS26;note=FunctionalCategory: PE/PPE, found on the mycobacterial cell surface, expression of this protein (in M. smegmatis) is associated with macrophage cell death, which is important for virulence [PMID: 18957600], expression of this protein is associated with increased levels of LDH and IL-10 [PMID: 18957600], expression of this protein is associated with decreased levels of IL-12 [PMID: 18957600], expression of this protein is associated with low NO levels [PMID: 18957600] chr1 CDS 1619791 1622091 . + . ID=CDS1;locus_tag=Rv1442;product=Probable biotin sulfoxide reductase BisC (BDS reductase) (BSO reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1622207 1622692 . - . ID=CDS1;locus_tag=Rv1443c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1623287 1623697 . - . ID=CDS1;locus_tag=Rv1444c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1623714 1624457 . - . ID=CDS1;locus_tag=Rv1445c;product=Probable 6-phosphogluconolactonase DevB (6PGL);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1624454 1625365 . - . ID=CDS1;locus_tag=Rv1446c;product=Putative OXPP cycle protein OpcA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1625418 1626962 . - . ID=CDS1;locus_tag=Rv1447c;product=Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1626959 1628080 . - . ID=CDS1;locus_tag=Rv1448c;product=Probable transaldolase Tal;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1628097 1630199 . - . ID=CDS1;locus_tag=Rv1449c;product=Transketolase Tkt (TK);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1630638 1634627 . - . ID=CDS1;locus_tag=Rv1450c;gene=PE_PGRS27;product=PE-PGRS family protein PE_PGRS27;note=FunctionalCategory: PE/PPE, found in the mycobacterial cell wall [PMID: 20825248], highly expressed when SigL is overexpressed [PMID: 16199577] chr1 CDS 1635029 1635955 . + . ID=CDS1;locus_tag=Rv1451;product=Probable cytochrome C oxidase assembly factor CtaB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1636004 1638229 . - . ID=CDS1;locus_tag=Rv1452c;gene=PE_PGRS28;product=PE-PGRS family protein PE_PGRS28;note=FunctionalCategory: PE/PPE chr1 CDS 1638381 1639646 . + . ID=CDS1;locus_tag=Rv1453;product=Possible transcriptional activator protein;note=FunctionalCategory: regulatory proteins chr1 CDS 1639674 1640660 . - . ID=CDS1;locus_tag=Rv1454c;product=Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1640680 1641543 . + . ID=CDS1;locus_tag=Rv1455;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1641493 1642425 . - . ID=CDS1;locus_tag=Rv1456c;product=Probable unidentified antibiotic-transport integral membrane ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1642537 1643322 . - . ID=CDS1;locus_tag=Rv1457c;product=Probable unidentified antibiotic-transport integral membrane ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1643319 1644260 . - . ID=CDS1;locus_tag=Rv1458c;product=Probable unidentified antibiotic-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1644363 1646138 . - . ID=CDS1;locus_tag=Rv1459c;product=α(1,6) mannopyranosyltransferase;Experiment=DESCRIPTION:Double mutant construction, in vitro mannosyltransferase activity assay [PMID: 18452585]/note:FunctionalCategory: cell wall and cell processes/note:Involved in the synthesis of the proximal end of the mannan backbone [PMID: 18452585];EC_number=2.4.1.- chr1 CDS 1646186 1646992 . + . ID=CDS1;locus_tag=Rv1460;product=Probable transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins, Belongs to the iron-sulfur cluster operon (Rv1460-Rv1466) (SUF system) [PMID: 16109955], Induced in NO and hydrogen peroxide stress [PMID: 21734908], Possibly induced in low iron conditions [PMID: 24155985] chr1 CDS 1646989 1649529 . + . ID=CDS1;locus_tag=Rv1461;product=Conserved protein;note=FunctionalCategory: conserved protein chr1 CDS 1649526 1650719 . + . ID=CDS1;locus_tag=Rv1462;product=putative transporter;note=FunctionalCategory: conserved hypotheticals, identified by similarity of predicted tertiary structure to PDB 4dn7A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4dn7A chr1 CDS 1650716 1651516 . + . ID=CDS1;locus_tag=Rv1463;product=Probable conserved ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1651980 1652771 . + . ID=CDS1;locus_tag=Rv1464;product=Probable cysteine desulfurase Csd;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1652768 1653256 . + . ID=CDS1;locus_tag=Rv1465;product=Possible nitrogen fixation related protein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1653231 1653578 . + . ID=CDS1;locus_tag=Rv1466;product=probable transcription activator;Experiment=DESCRIPTION:yeast two-hybrid assay [PMID: 16109955]/note:FunctionalCategory: conserved hypotheticals/note:complementation into S. aureus restored iron-sulfur cluster maturation capability when S. aureus SufT was knocked out [PMID: 27517714] chr1 CDS 1653673 1655502 . - . ID=CDS1;locus_tag=Rv1467c;product=Probable acyl-CoA dehydrogenase FadE15;note=FunctionalCategory: lipid metabolism chr1 CDS 1655609 1656721 . - . ID=CDS1;locus_tag=Rv1468c;gene=PE_PGRS29;product=Probable antigen;Experiment=DESCRIPTION:protein expression and purification, indirect ELISA (identification of antigenic proteins by reaction with human serum) [PMID: 20690665],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry. [PMID: 21261938],Experiment=EXISTENCE:liquid chromatography-mass spectrometry. [PMID: 21085642],Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:IS6110 insertion site located 297 bp upstream of this gene (IS element insertion reported in Beijing strains) [PMID: 21256084] [PMID: 15130120]/note:IS element insertion upstream of this gene results in the overexpression of the gene during growth in human monocytes [PMID: 16725220],Experiment=ally. [PMID: 21920479]/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection. [PMID: 21085642]/note:Found in the cell membrane [PMID: 21261938,21920479] chr1 CDS 1656963 1658936 . + . ID=CDS1;locus_tag=Rv1469;product=Probable cation transporter P-type ATPase D CtpD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1658980 1659354 . + . ID=CDS1;locus_tag=Rv1470;product=Probable thioredoxin TrxA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1659370 1659741 . + . ID=CDS1;locus_tag=Rv1471;product=Probable thioredoxin TrxB1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1659763 1660620 . + . ID=CDS1;locus_tag=Rv1472;product=Possible enoyl-CoA hydratase EchA12 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 1660656 1662284 . + . ID=CDS1;locus_tag=Rv1473;product=Probable macrolide-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1662381 1662572 . + . ID=CDS1;locus_tag=Rv1473A;product=Possible transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 1662641 1663204 . - . ID=CDS1;locus_tag=Rv1474c;product=Probable TetR-like transcriptional repressor of aconitase;Experiment=DESCRIPTION:Protein purification and expression in E. Coli, Glutaraldehyde cross-linking assay, RT-PCR, EMSA, DNA minor and major groove-binding assays, CD Spectroscopy, β-galactosidase assay, Fluorescence measurements [PMID: 26902658]/note:FunctionalCategory: regulatory proteins/note:binds upstream of the acn operon [PMID: 26902658]/note:Rv1474c binds to inverted DNA repeat sequence in a tetracycline dependent and iron responsive manner [PMID: 26902658] chr1 CDS 1663215 1666046 . - . ID=CDS1;locus_tag=Rv1475c;product=Probable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1666204 1666764 . + . ID=CDS1;locus_tag=Rv1476;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1666990 1668408 . + . ID=CDS1;locus_tag=Rv1477;product=Peptidoglycan hydrolase;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1668419 1669144 . + . ID=CDS1;locus_tag=Rv1478;gene=ripB;product=peptidoglycan hydrolase RipB;Experiment=DESCRIPTION:protein expression and purification, x-ray crystallography, peptidoglycan binding assay, enzyme activity assay (using defined peptidoglycan substrates) [PMID: 21864539]/inference:alignment:ClustalW [PMID: 21864539]/note:FunctionalCategory: virulence, detoxification, adaptation/note:Hydrolyzed only small peptidoglycan fragments (Bacillus subtilis derived high-molecular-weight peptidoglycans used as substrate) [PMID: 21864539]/note:belongs to the NlpC/p60 family [PMID: 21864539]/note:cleaves particular peptidoglycan fragments between d-glutamate and meso-diaminopimelate [PMID: 21864539];EC_number=3.2.1.-,EC_number=3.4.19.11 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3i86A/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 1669283 1670416 . + . ID=CDS1;locus_tag=Rv1479;product=Probable transcriptional regulatory protein MoxR1;note=FunctionalCategory: regulatory proteins;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1670413 1671366 . + . ID=CDS1;locus_tag=Rv1480;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1671377 1672384 . + . ID=CDS1;locus_tag=Rv1481;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1672457 1673299 . - . ID=CDS1;locus_tag=Rv1482c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1673440 1674183 . + . ID=CDS1;locus_tag=Rv1483;product=3-oxoacyl-[acyl-carrier protein] reductase FabG1 (3-ketoacyl-acyl carrier protein reductase) (mycolic acid biosynthesis a protein);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1674202 1675011 . + . ID=CDS1;locus_tag=Rv1484;product=NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase);note=FunctionalCategory: lipid metabolism chr1 CDS 1675017 1676051 . + . ID=CDS1;locus_tag=Rv1485;product=Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1676017 1676883 . - . ID=CDS1;locus_tag=Rv1486c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1676941 1677375 . + . ID=CDS1;locus_tag=Rv1487;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1677397 1678542 . + . ID=CDS1;locus_tag=Rv1488;product=Probable antigen;Experiment=DESCRIPTION:Indirect ELISA [PMID: 26481294]/note:FunctionalCategory: cell wall and cell processes/note:Among the sputum sample tested from 10 patients, this probable seropositive antigen was identified in at least 2 patients [PMID: 26481294] chr1 CDS 1678552 1678908 . + . ID=CDS1;locus_tag=Rv1489;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1678942 1679172 . + . ID=CDS1;locus_tag=Rv1489A;product=Conserved protein/probable mutase (Intramolecular transferase);note=FunctionalCategory: conserved hypotheticals;EC_number=5.4.99.-;Ontology_term=0031419/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1,Ontology_term=0004494/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1,Ontology_term=0016866/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1e1cA,1e1cA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e1cA,1e1cA1 chr1 CDS 1679322 1680629 . + . ID=CDS1;locus_tag=Rv1490;product=Probable receptor binding T-cell antigen/membrane protein;Experiment=Molecular assays, SDS-PAGE, immunoblotting, immuno-electron microscopy, cell-binding assays, entry inhibition assays, mycobacterial entry assay [PMID: 18585422]/inference:ab initio prediction:PROTPARAM,TMHMM, TMPRED [PMID: 18585422]/note:FunctionalCategory: cell wall and cell processes/note:Involved in target cell entry during infection [PMID: 18585422] chr1 CDS 1681208 1681966 . - . ID=CDS1;locus_tag=Rv1491c;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1682157 1684004 . + . ID=CDS1;locus_tag=Rv1492;product=Probable methylmalonyl-CoA mutase small subunit MutA (MCM);note=FunctionalCategory: lipid metabolism chr1 CDS 1684005 1686257 . + . ID=CDS1;locus_tag=Rv1493;product=Probable methylmalonyl-CoA mutase large subunit MutB (MCM);note=FunctionalCategory: lipid metabolism chr1 CDS 1686271 1686573 . + . ID=CDS1;locus_tag=Rv1494;product=Possible antitoxin MazE4;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1686570 1686887 . + . ID=CDS1;locus_tag=Rv1495;product=Possible toxin MazF4;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1686878 1687888 . + . ID=CDS1;locus_tag=Rv1496;product=Possible transport system kinase;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1687941 1689230 . + . ID=CDS1;locus_tag=Rv1497;product=Probable esterase LipL;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1689303 1689920 . - . ID=CDS1;locus_tag=Rv1498c;product=Probable methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1690134 1690346 . - . ID=CDS1;locus_tag=Rv1498A;product=Dodecin;Experiment=DESCRIPTION:crystal structure determination (X-ray crystallography), ultraviolet-visible spectrometry, MALDI-TOF-MS, ITC, recombinant DNA expression [PMID: 21539921]/note:FunctionalCategory: conserved hypotheticals/note:flavin-binding protein chr1 CDS 1690407 1690805 . + . ID=CDS1;locus_tag=Rv1499;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1690850 1691878 . + . ID=CDS1;locus_tag=Rv1500;product=Probable glycosyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1691890 1692711 . + . ID=CDS1;locus_tag=Rv1501;product=putative oxoglutarate dioxygenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.14.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4y5sA,2rdnA,2a1xA,3emrA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0019491/note:identified by similarity of predicted tertiary structure to PDB 3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3emrA,Ontology_term=0005782/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 2rdnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=1902181/note:identified by similarity of predicted tertiary structure to PDB 4y5sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,Ontology_term=0042400/note:identified by similarity of predicted tertiary structure to PDB 3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3emrA,Ontology_term=0048244/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4y5sA,2rdnA,2a1xA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,2rdnA,2a1xA,3emrA,Ontology_term=0031418/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,2a1xA,Ontology_term=0001561/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0016706/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,3emrA,Ontology_term=0005777/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0005506/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,3emrA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,2a1xA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,2a1xA,3emrA,Ontology_term=0097089/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0006103/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0006720/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0008198/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4y5sA,2rdnA,2a1xA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,2rdnA,2a1xA,3emrA,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 4y5sA,2rdnA,2a1xA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,2rdnA,2a1xA,3emrA,Ontology_term=1901336/note:identified by similarity of predicted tertiary structure to PDB 2rdnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,Ontology_term=0031406/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA chr1 CDS 1692924 1693823 . + . ID=CDS1;locus_tag=Rv1502;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 1693996 1694544 . - . ID=CDS1;locus_tag=Rv1503c;product=Putative dTDP-4-amino-4,6-dideoxygalactose transaminase;note=probable role in regulation of di-O-acyl-trehalose synthesis and sulfolipid synthesis;Experiment=DESCRIPTION:MALDI-Tof-MS, NMR, in vivo recombinant DNA expression, confocal microscopy and fluorescence assay [PMID: 20844580]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.6.1.59 (Putative);Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0009246/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0019180/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0030170/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA chr1 CDS 1694545 1695144 . - . ID=CDS1;locus_tag=Rv1504c;product=Probable transaminase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.6.1.102 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3dr4C/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.100 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:2c7tA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.87 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:1mdoA,4lc3A/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.109 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:5k8bA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.59 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4piwA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.98 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3nu7A/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.2.1.144 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1b9iA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.106 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2ogaA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.104 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4k2bA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.92 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2fniA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0102933/note:identified by similarity of predicted tertiary structure to PDB 3dr4C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dr4C,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 2c7tA,1b9iA,2ogaA,4k2bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c7tA,1b9iA,2ogaA,4k2bA,Ontology_term=0008483/note:identified by similarity of predicted tertiary structure to PDB 3dr4C,2c7tA,1mdoA,5k8bA,3nu7A,2ogaA,4k2bA,2fniA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dr4C,2c7tA,1mdoA,5k8bA,3nu7A,2ogaA,4k2bA,2fniA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 1mdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mdoA,Ontology_term=0030170/note:identified by similarity of predicted tertiary structure to PDB 4piwA,3nu7A,2ogaA,4k2bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,3nu7A,2ogaA,4k2bA,Ontology_term=0009103/note:identified by similarity of predicted tertiary structure to PDB 3dr4C,1mdoA,5k8bA,3nu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dr4C,1mdoA,5k8bA,3nu7A,Ontology_term=0019180/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 1b9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b9iA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 3nu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nu7A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3dr4C,2c7tA,1mdoA,5k8bA,4piwA,3nu7A,1b9iA,2ogaA,4k2bA,2fniA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dr4C,2c7tA,1mdoA,5k8bA,4piwA,3nu7A,1b9iA,2ogaA,4k2bA,2fniA,Ontology_term=0033068/note:identified by similarity of predicted tertiary structure to PDB 2ogaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ogaA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 1mdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mdoA,Ontology_term=0009243/note:identified by similarity of predicted tertiary structure to PDB 3dr4C,3nu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dr4C,3nu7A,Ontology_term=0000271/note:identified by similarity of predicted tertiary structure to PDB 5k8bA,3nu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5k8bA,3nu7A,Ontology_term=0009246/note:identified by similarity of predicted tertiary structure to PDB 4piwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4piwA,Ontology_term=0009245/note:identified by similarity of predicted tertiary structure to PDB 1mdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mdoA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3dr4C,2c7tA,1mdoA,4lc3A,5k8bA,4piwA,3nu7A,1b9iA,2ogaA,4k2bA,2fniA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dr4C,2c7tA,1mdoA,4lc3A,5k8bA,4piwA,3nu7A,1b9iA,2ogaA,4k2bA,2fniA,Ontology_term=0099620/note:identified by similarity of predicted tertiary structure to PDB 1mdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mdoA,Ontology_term=0006065/note:identified by similarity of predicted tertiary structure to PDB 3nu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nu7A chr1 CDS 1695281 1695946 . - . ID=CDS1;locus_tag=Rv1505c;product=probable acyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.3.1.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3t57A,5demA,2jf2A,3pmoA,4ea7A,3r0sA,4eqyA,3i3xA,4e6tA,3vbiA,4r36A,3mqgA,3bssA,1j2zA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 3t57A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 5demA,2jf2A,3r0sA,4eqyA,3i3xA,4r36A,1j2zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5demA,2jf2A,3r0sA,4eqyA,3i3xA,4r36A,1j2zA,Ontology_term=0006486/note:identified by similarity of predicted tertiary structure to PDB 3bssA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bssA,Ontology_term=0008780/note:identified by similarity of predicted tertiary structure to PDB 3t57A,5demA,2jf2A,3r0sA,4eqyA,3i3xA,4e6tA,4r36A,1j2zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,5demA,2jf2A,3r0sA,4eqyA,3i3xA,4e6tA,4r36A,1j2zA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3mqgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mqgA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3t57A,5demA,2jf2A,3pmoA,4ea7A,3r0sA,4eqyA,3i3xA,4e6tA,3vbiA,4r36A,3mqgA,3bssA,1j2zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,5demA,2jf2A,3pmoA,4ea7A,3r0sA,4eqyA,3i3xA,4e6tA,3vbiA,4r36A,3mqgA,3bssA,1j2zA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 3t57A,5demA,2jf2A,3pmoA,3r0sA,4eqyA,3i3xA,4r36A,3mqgA,3bssA,1j2zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,5demA,2jf2A,3pmoA,3r0sA,4eqyA,3i3xA,4r36A,3mqgA,3bssA,1j2zA,Ontology_term=0016747/note:identified by similarity of predicted tertiary structure to PDB 3pmoA,3bssA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pmoA,3bssA,Ontology_term=0016410/note:identified by similarity of predicted tertiary structure to PDB 3pmoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pmoA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4r36A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4r36A,Ontology_term=0018279/note:identified by similarity of predicted tertiary structure to PDB 3bssA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bssA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2jf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jf2A,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3t57A,5demA,2jf2A,3pmoA,3r0sA,4eqyA,3i3xA,4r36A,1j2zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,5demA,2jf2A,3pmoA,3r0sA,4eqyA,3i3xA,4r36A,1j2zA,Ontology_term=0008610/note:identified by similarity of predicted tertiary structure to PDB 3t57A,5demA,2jf2A,3r0sA,4eqyA,3i3xA,4e6tA,4r36A,1j2zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,5demA,2jf2A,3r0sA,4eqyA,3i3xA,4e6tA,4r36A,1j2zA,Ontology_term=0009245/note:identified by similarity of predicted tertiary structure to PDB 3t57A,5demA,2jf2A,3pmoA,3r0sA,4eqyA,3i3xA,4r36A,1j2zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,5demA,2jf2A,3pmoA,3r0sA,4eqyA,3i3xA,4r36A,1j2zA,Ontology_term=2001289/note:identified by similarity of predicted tertiary structure to PDB 3t57A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t57A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2jf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jf2A chr1 CDS 1695943 1696443 . - . ID=CDS1;locus_tag=Rv1506c;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 1696727 1697422 . - . ID=CDS1;locus_tag=Rv1507c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1697356 1697859 . + . ID=CDS1;locus_tag=Rv1507A;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 1698095 1699894 . - . ID=CDS1;locus_tag=Rv1508c;product=Antigen;Experiment=DESCRIPTION:ELISA [PMID: 21177915]/inference:profile:ABCpred [PMID: 21177915]/note:FunctionalCategory: cell wall and cell processes/note:induced and exported in vivo [PMID: 28442606] chr1 CDS 1699866 1700228 . + . ID=CDS1;locus_tag=Rv1508A;product=Putative GDP-mannose 4,6-dehydratase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.2.1.47 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1n7gB,1rpnC,1db3A,1t2aA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0019673/note:identified by similarity of predicted tertiary structure to PDB 1n7gB,1rpnC,1db3A,1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,1rpnC,1db3A,1t2aA,Ontology_term=0008446/note:identified by similarity of predicted tertiary structure to PDB 1n7gB,1rpnC,1db3A,1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,1rpnC,1db3A,1t2aA,Ontology_term=0009826/note:identified by similarity of predicted tertiary structure to PDB 1n7gB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,Ontology_term=0007219/note:identified by similarity of predicted tertiary structure to PDB 1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t2aA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t2aA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 1n7gB,1rpnC,1db3A,1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,1rpnC,1db3A,1t2aA,Ontology_term=0042351/note:identified by similarity of predicted tertiary structure to PDB 1n7gB,1db3A,1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,1db3A,1t2aA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1n7gB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,Ontology_term=0009103/note:identified by similarity of predicted tertiary structure to PDB 1rpnC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rpnC,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t2aA,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 1n7gB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t2aA,Ontology_term=0009243/note:identified by similarity of predicted tertiary structure to PDB 1rpnC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rpnC,Ontology_term=0009242/note:identified by similarity of predicted tertiary structure to PDB 1db3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1db3A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1n7gB,1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n7gB,1t2aA,Ontology_term=0070401/note:identified by similarity of predicted tertiary structure to PDB 1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t2aA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1t2aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t2aA,Ontology_term=0019306/note:identified by similarity of predicted tertiary structure to PDB 1rpnC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rpnC chr1 CDS 1700212 1701093 . + . ID=CDS1;locus_tag=Rv1509;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 1701343 1702593 . + . ID=CDS1;locus_tag=Rv1510;product=Conserved probable membrane protein/putative Na+/H+ antiporter drug efflux protein;note=FunctionalCategory: cell wall and cell processes, potential MATE drug efflux pump, strong structural similarity with three different MATE (Multidrug and toxic compound extrusion proteins) transporters, identified by similarity of predicted tertiary structure to PDB 3vvnA,4z3nA,4lz6A,3mktA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vvnA,4z3nA,4lz6A,3mktA chr1 CDS 1703074 1704096 . + . ID=CDS1;locus_tag=Rv1511;product=GDP-D-mannose dehydratase GmdA (GDP-mannose 4,6 dehydratase) (GMD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1704093 1705061 . + . ID=CDS1;locus_tag=Rv1512;product=Probable nucleotide-sugar epimerase EpiA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1705058 1705789 . + . ID=CDS1;locus_tag=Rv1513;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1705807 1706595 . - . ID=CDS1;locus_tag=Rv1514c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1706630 1707526 . - . ID=CDS1;locus_tag=Rv1515c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1707529 1708539 . - . ID=CDS1;locus_tag=Rv1516c;product=Probable sugar transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1708871 1709635 . + . ID=CDS1;locus_tag=Rv1517;product=Conserved hypothetical transmembrane protein;note=FunctionalCategory: cell wall and cell processes, Regulated by the PhoPR system [PMID: 16573683], induced and exported in vivo [PMID: 28442606] chr1 CDS 1709644 1710603 . + . ID=CDS1;locus_tag=Rv1518;product=putative hexosyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.4.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4fixA,2d7rA,2ffuA,3ckqA,3f1yA,2wvkA,2z86C,1xhbA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008921/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0030246/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0052573/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0070592/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0045227/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0050510/note:identified by similarity of predicted tertiary structure to PDB 2z86C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z86C,Ontology_term=0044038/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2wvkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wvkA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0006486/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0051479/note:identified by similarity of predicted tertiary structure to PDB 2wvkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wvkA,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4fixA,2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,2d7rA,Ontology_term=0004653/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4fixA,2d7rA,3ckqA,3f1yA,2wvkA,2z86C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,2d7rA,3ckqA,3f1yA,2wvkA,2z86C,Ontology_term=0047238/note:identified by similarity of predicted tertiary structure to PDB 2z86C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z86C,Ontology_term=0071769/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4fixA,2d7rA,3ckqA,2wvkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,2d7rA,3ckqA,2wvkA,Ontology_term=0005794/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0016266/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0009103/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0035250/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0050504/note:identified by similarity of predicted tertiary structure to PDB 3f1yA,2wvkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f1yA,2wvkA,Ontology_term=0006493/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,Ontology_term=0000139/note:identified by similarity of predicted tertiary structure to PDB 2d7rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d7rA,Ontology_term=0016757/note:identified by similarity of predicted tertiary structure to PDB 4fixA,2d7rA,3ckqA,3f1yA,2wvkA,2z86C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA,2d7rA,3ckqA,3f1yA,2wvkA,2z86C,Ontology_term=0035496/note:identified by similarity of predicted tertiary structure to PDB 4fixA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fixA chr1 CDS 1710733 1711002 . + . ID=CDS1;locus_tag=Rv1519;product=Conserved hypothetical protein;Experiment=DESCRIPTION:in vitro recombinant DNA expression with fluorescent tagging, gel retardation assay [PMID: 16113319],Experiment=DESCRIPTION:in vivo recombinant DNA expression, RT-PCR, Luciferase assay/note:FunctionalCategory: conserved hypotheticals/note:regulated by IdeR, modifies interaction with monocyte-derived macrophages chr1 CDS 1711028 1712068 . + . ID=CDS1;locus_tag=Rv1520;product=Probable sugar transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1712302 1714053 . + . ID=CDS1;locus_tag=Rv1521;product=Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1714172 1717612 . - . ID=CDS1;locus_tag=Rv1522c;product=Probable conserved transmembrane transport protein MmpL12;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1717653 1718696 . + . ID=CDS1;locus_tag=Rv1523;product=Probable methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1718726 1719970 . + . ID=CDS1;locus_tag=Rv1524;product=Probable glycosyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1720017 1720802 . + . ID=CDS1;locus_tag=Rv1525;gene=wbbL2;product=Putative rhamnosyl transferase WbbL2;Experiment=DESCRIPTION:in vitro kinase assay, proteome microarray analysis [PMID: 25497094]/note:FunctionalCategory: conserved hypotheticals/note:interacts with c-di-GMP/note:phosphorylated by PknA;EC_number=2.4.1.- chr1 CDS 1720780 1722060 . - . ID=CDS1;locus_tag=Rv1526c;product=Probable glycosyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1722083 1728409 . - . ID=CDS1;locus_tag=Rv1527c;product=Probable polyketide synthase Pks5;note=FunctionalCategory: lipid metabolism chr1 CDS 1728953 1729450 . - . ID=CDS1;locus_tag=Rv1528c;product=Probable conserved polyketide synthase associated protein PapA4;note=FunctionalCategory: lipid metabolism chr1 CDS 1729502 1731256 . + . ID=CDS1;locus_tag=Rv1529;product=Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1731373 1732476 . + . ID=CDS1;locus_tag=Rv1530;product=Probable alcohol dehydrogenase Adh;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1732473 1733039 . + . ID=CDS1;locus_tag=Rv1531;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1733116 1733550 . - . ID=CDS1;locus_tag=Rv1532c;product=putative thioester hydrolase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3f5oA,2b6eD,3s4kA,4ae8A,2fs2B,1vi8B,1sc0A,1vh9A,1q4sA,4qd7A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006637/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0016790/note:identified by similarity of predicted tertiary structure to PDB 2fs2B,1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fs2B,1vh9A,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0009234/note:identified by similarity of predicted tertiary structure to PDB 1vi8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vi8B,Ontology_term=0010124/note:identified by similarity of predicted tertiary structure to PDB 2fs2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fs2B,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3f5oA,1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,1vh9A,Ontology_term=0016289/note:identified by similarity of predicted tertiary structure to PDB 2fs2B,1vi8B,1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fs2B,1vi8B,1vh9A,Ontology_term=0005819/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0009239/note:identified by similarity of predicted tertiary structure to PDB 1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vh9A,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vh9A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3f5oA,2b6eD,3s4kA,2fs2B,1vi8B,1sc0A,1vh9A,1q4sA,4qd7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,2b6eD,3s4kA,2fs2B,1vi8B,1sc0A,1vh9A,1q4sA,4qd7A,Ontology_term=0016788/note:identified by similarity of predicted tertiary structure to PDB 1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vh9A,Ontology_term=0061522/note:identified by similarity of predicted tertiary structure to PDB 1vi8B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vi8B,Ontology_term=0047617/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3f5oA,1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,1vh9A,Ontology_term=0005856/note:identified by similarity of predicted tertiary structure to PDB 3f5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f5oA,Ontology_term=0018739/note:identified by similarity of predicted tertiary structure to PDB 1q4sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1q4sA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1vh9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vh9A chr1 CDS 1733610 1734737 . + . ID=CDS1;locus_tag=Rv1533;product=putative nitronate monooxygenase;Experiment=DESCRIPTION:recombinant DNA expression, enzyme activity assay, inhibition assay [PMID: 23408846]/note:FunctionalCategory: conserved hypotheticals,Experiment=s performed on homolog Rv1894c (determined via alignment);EC_number=1.13.12.16 chr1 CDS 1734734 1735411 . + . ID=CDS1;locus_tag=Rv1534;product=Probable transcriptional regulator/putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0019217/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,3vprA,3himB,2ibdA,4g12A,3f1bA,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,3vprA,3himB,2ibdA,4g12A,3f1bA,4w97A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,3vprA,3himB,2ibdA,4g12A,3f1bA,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,3vprA,3himB,2ibdA,4g12A,3f1bA,4w97A,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2g3bB,5e57A,3vprA,3himB,2ibdA,4g12A,4udsA,3f1bA,4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g3bB,5e57A,3vprA,3himB,2ibdA,4g12A,4udsA,3f1bA,4w97A,Ontology_term=0010468/note:identified by similarity of predicted tertiary structure to PDB 4w97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3vprA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vprA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 4w97A,2ibdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4w97A,2ibdA chr1 CDS 1735976 1736212 . + . ID=CDS1;locus_tag=Rv1535;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1736519 1739644 . + . ID=CDS1;locus_tag=Rv1536;product=Isoleucyl-tRNA synthetase IleS;note=FunctionalCategory: information pathways chr1 CDS 1739856 1741247 . + . ID=CDS1;locus_tag=Rv1537;product=Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed));note=FunctionalCategory: information pathways chr1 CDS 1741212 1742192 . - . ID=CDS1;locus_tag=Rv1538c;product=Probable L-asparaginase AnsA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1742244 1742852 . + . ID=CDS1;locus_tag=Rv1539;product=Probable lipoprotein signal peptidase LspA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1742845 1743771 . + . ID=CDS1;locus_tag=Rv1540;product=Conserved hypothetical protein member of yabO/yceC/yfiI family, Putative 23S rRNA pseudouridine(1911/1915/1917) synthase.;note=FunctionalCategory: conserved hypotheticals;EC_number=5.4.99.23 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2istA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0009451/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0000455/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0001522/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0000027/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0019239/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0009982/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA chr1 CDS 1743778 1744371 . - . ID=CDS1;locus_tag=Rv1541c;product=Possible lipoprotein LprI;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1744426 1744836 . - . ID=CDS1;locus_tag=Rv1542c;product=Hemoglobin GlbN;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1745064 1746089 . + . ID=CDS1;locus_tag=Rv1543;product=Possible fatty acyl-CoA reductase;note=FunctionalCategory: lipid metabolism chr1 CDS 1746094 1746897 . + . ID=CDS1;locus_tag=Rv1544;product=Possible ketoacyl reductase;note=FunctionalCategory: lipid metabolism chr1 CDS 1746919 1747146 . + . ID=CDS1;locus_tag=Rv1545;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1747195 1747626 . + . ID=CDS1;locus_tag=Rv1546;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, information pathways chr1 CDS 1747694 1751248 . + . ID=CDS1;locus_tag=Rv1547;product=Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase);note=FunctionalCategory: information pathways chr1 CDS 1751297 1753333 . - . ID=CDS1;locus_tag=Rv1548c;gene=PPE21;product=PPE family protein PPE21;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection. [PMID: 21085642]/note:potential carbohydrate recognition protein/note:identified by similarity of predicted tertiary structure to PDB 5ak1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ak1A chr1 CDS 1753510 1754037 . + . ID=CDS1;locus_tag=Rv1549;product=Possible fatty-acid-CoA ligase FadD11.1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1753716 1755431 . + . ID=CDS1;locus_tag=Rv1550;product=Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1755445 1757310 . + . ID=CDS1;locus_tag=Rv1551;product=Possible acyltransferase PlsB1;note=FunctionalCategory: lipid metabolism chr1 CDS 1757681 1759432 . + . ID=CDS1;locus_tag=Rv1552;product=Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1759435 1760178 . + . ID=CDS1;locus_tag=Rv1553;product=Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1760175 1760555 . + . ID=CDS1;locus_tag=Rv1554;product=Probable fumarate reductase [membrane anchor subunit] FrdC (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1760552 1760929 . + . ID=CDS1;locus_tag=Rv1555;product=Probable fumarate reductase [membrane anchor subunit] FrdD (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1761009 1761605 . + . ID=CDS1;locus_tag=Rv1556;product=Possible regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2fq4A,2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fq4A,2zb9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2fq4A,2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fq4A,2zb9A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2fq4A,2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fq4A,2zb9A,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 2fq4A,2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fq4A,2zb9A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2fq4A,2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fq4A,2zb9A,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2fq4A,2zb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fq4A,2zb9A chr1 CDS 1761744 1762937 . + . ID=CDS1;locus_tag=Rv1557;product=Probable conserved transmembrane transport protein MmpL6;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1762947 1763393 . + . ID=CDS1;locus_tag=Rv1558;product=F420-H2-dependent quinone reductase;Experiment=DESCRIPTION:Enzyme assay, mass spectrometry, allelic exchange gene deficient mutant [PMID: 23240649]/inference:alignment: multiple sequence alignment [PMID: 23240649]/note:FunctionalCategory: conserved hypotheticals;EC_number=1.6.5.2 chr1 CDS 1763428 1764717 . + . ID=CDS1;locus_tag=Rv1559;product=Probable threonine dehydratase IlvA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1764755 1764973 . + . ID=CDS1;locus_tag=Rv1560;product=Possible antitoxin VapB11;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1764979 1765383 . + . ID=CDS1;locus_tag=Rv1561;product=Possible toxin VapC11;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1765400 1767142 . - . ID=CDS1;locus_tag=Rv1562c;product=Maltooligosyltrehalose trehalohydrolase TreZ;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1767135 1769432 . - . ID=CDS1;locus_tag=Rv1563c;product=Maltooligosyltrehalose synthase TreY;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1769436 1771601 . - . ID=CDS1;locus_tag=Rv1564c;product=Probable maltooligosyltrehalose synthase TreX;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1771640 1773829 . - . ID=CDS1;locus_tag=Rv1565c;product=Conserved hypothetical membrane protein;note=FunctionalCategory: cell wall and cell processes, Possibly plays a role in the synthesis of the mannose cap on lipoarabinomannan [PMID: 20688818] chr1 CDS 1773928 1774620 . - . ID=CDS1;locus_tag=Rv1566c;gene=ripD;product=probable non-catalytic peptidoglycan binding RipD protein | probable antigen;Experiment=DESCRIPTION:protein crystallization, enzyme activity assay, peptidoglycan binding assay [PMID: 24107184],Experiment=DESCRIPTION:Indirect ELISA [PMID: 26481294]/inference:ab initio prediction:Phaser [PMID: 24107184]/inference:alignment:ClustalW [PMID: 24107184]/note:FunctionalCategory: virulence, detoxification, adaptation/note:possible invasion protein/note:contains NlpC/P60 domain that lacks catalytic activity but retains peptidoglycan binding function [PMID: 24107184]/note:Among the sputum sample tested from 10 patients, this probable seropositive antigen was identified in at least 2 patients [PMID: 26481294] chr1 CDS 1774860 1775144 . - . ID=CDS1;locus_tag=Rv1567c;product=Probable hypothetical membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1775392 1776705 . + . ID=CDS1;locus_tag=Rv1568;product=Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1776702 1777862 . + . ID=CDS1;locus_tag=Rv1569;product=Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1777859 1778539 . + . ID=CDS1;locus_tag=Rv1570;product=Dethiobiotin synthetase BioD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1778539 1779048 . + . ID=CDS1;locus_tag=Rv1571;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1779194 1779298 . - . ID=CDS1;locus_tag=Rv1572c;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1779314 1779724 . + . ID=CDS1;locus_tag=Rv1573;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1779930 1780241 . + . ID=CDS1;locus_tag=Rv1574;product=Probable PhiRv1 phage related protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1780199 1780699 . + . ID=CDS1;locus_tag=Rv1575;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1780643 1782064 . - . ID=CDS1;locus_tag=Rv1576c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1782072 1782584 . - . ID=CDS1;locus_tag=Rv1577c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1782758 1783228 . - . ID=CDS1;locus_tag=Rv1578c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1783309 1783623 . - . ID=CDS1;locus_tag=Rv1579c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1783620 1783892 . - . ID=CDS1;locus_tag=Rv1580c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1783906 1784301 . - . ID=CDS1;locus_tag=Rv1581c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1784497 1785912 . - . ID=CDS1;locus_tag=Rv1582c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1785912 1786310 . - . ID=CDS1;locus_tag=Rv1583c;product=Probable PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1786307 1786528 . - . ID=CDS1;locus_tag=Rv1584c;product=Possible PhiRv1 phage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1786584 1787099 . - . ID=CDS1;locus_tag=Rv1585c;product=Possible phage PhiRv1 protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1787096 1788505 . - . ID=CDS1;locus_tag=Rv1586c;product=Probable PhiRv1 integrase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1788162 1789163 . - . ID=CDS1;locus_tag=Rv1587c;product=Partial REP13E12 repeat protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1789168 1789836 . - . ID=CDS1;locus_tag=Rv1588c;product=Partial REP13E12 repeat protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1790284 1791333 . + . ID=CDS1;locus_tag=Rv1589;product=Probable biotin synthetase BioB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1791334 1791573 . + . ID=CDS1;locus_tag=Rv1590;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1791570 1792235 . + . ID=CDS1;locus_tag=Rv1591;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1792400 1793740 . - . ID=CDS1;locus_tag=Rv1592c;product=esterase;note=FunctionalCategory: conserved hypotheticals;Experiment=DESCRIPTION:protein purification and characterization, enzyme activity assay[PMID: 27050490]/inference:ab initio prediction:3D structure prediction using YASARA and PROCHECK, in silico docking studies [PMID: 27050490];EC_number=3.1.1.- chr1 CDS 1793997 1794707 . - . ID=CDS1;locus_tag=Rv1593c;product=Conserved protein/putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3gz6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gz6A chr1 CDS 1794756 1795805 . + . ID=CDS1;locus_tag=Rv1594;product=Probable quinolinate synthetase NadA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1795805 1797388 . + . ID=CDS1;locus_tag=Rv1595;product=Probable L-aspartate oxidase NadB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1797388 1798245 . + . ID=CDS1;locus_tag=Rv1596;product=Probable nicotinate-nucleotide pyrophosphatase NadC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1798294 1799052 . + . ID=CDS1;locus_tag=Rv1597;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 1vl5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vl5A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 1vl5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vl5A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1vl5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vl5A chr1 CDS 1799073 1799483 . - . ID=CDS1;locus_tag=Rv1598c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1799583 1800899 . + . ID=CDS1;locus_tag=Rv1599;product=Probable histidinol dehydrogenase HisD (HDH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1800896 1802038 . + . ID=CDS1;locus_tag=Rv1600;product=Probable histidinol-phosphate aminotransferase HisC1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1802035 1802667 . + . ID=CDS1;locus_tag=Rv1601;product=Probable imidazole glycerol-phosphate dehydratase HisB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1802664 1803284 . + . ID=CDS1;locus_tag=Rv1602;product=Probable amidotransferase HisH;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1803294 1804031 . + . ID=CDS1;locus_tag=Rv1603;product=Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1804039 1804851 . + . ID=CDS1;locus_tag=Rv1604;product=Probable inositol-monophosphatase ImpA (imp);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1804853 1805656 . + . ID=CDS1;locus_tag=Rv1605;product=Probable cyclase HisF;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1805653 1806000 . + . ID=CDS1;locus_tag=Rv1606;product=Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1806181 1807263 . + . ID=CDS1;locus_tag=Rv1607;product=Probable ionic transporter integral membrane protein ChaA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1807298 1807762 . - . ID=CDS1;locus_tag=Rv1608c;product=Probable peroxidoxin BcpB;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1807903 1809453 . + . ID=CDS1;locus_tag=Rv1609;product=Anthranilate synthase component I TrpE (glutamine amidotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1809443 1810150 . + . ID=CDS1;locus_tag=Rv1610;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1810240 1811058 . + . ID=CDS1;locus_tag=Rv1611;product=Probable indole-3-glycerol phosphate synthase TrpC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1811091 1812359 . + . ID=CDS1;locus_tag=Rv1612;product=Tryptophan synthase, beta subunit TrpB;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1812359 1813171 . + . ID=CDS1;locus_tag=Rv1613;product=Probable tryptophan synthase, alpha subunit TrpA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1813171 1814577 . + . ID=CDS1;locus_tag=Rv1614;product=Possible prolipoprotein diacylglyceryl transferases Lgt;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1815253 1815693 . + . ID=CDS1;locus_tag=Rv1615;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1815683 1816081 . + . ID=CDS1;locus_tag=Rv1616;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1816189 1817607 . + . ID=CDS1;locus_tag=Rv1617;product=Probable pyruvate kinase PykA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1817615 1818517 . + . ID=CDS1;locus_tag=Rv1618;product=Probable acyl-CoA thioesterase II TesB1;note=FunctionalCategory: lipid metabolism chr1 CDS 1818575 1820029 . + . ID=CDS1;locus_tag=Rv1619;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1819963 1821693 . - . ID=CDS1;locus_tag=Rv1620c;product=Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1821690 1823273 . - . ID=CDS1;locus_tag=Rv1621c;product=Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1823360 1824400 . - . ID=CDS1;locus_tag=Rv1622c;product=Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB (cytochrome BD-I oxidase subunit II);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1824430 1825887 . - . ID=CDS1;locus_tag=Rv1623c;product=Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA (cytochrome BD-I oxidase subunit I);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1825998 1826585 . - . ID=CDS1;locus_tag=Rv1624c;product=Probable conserved membrane protein/putative membrane transport protein;note=FunctionalCategory: cell wall and cell processes, identified by similarity of predicted tertiary structure to PDB 4ybqA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ybqA chr1 CDS 1826614 1827945 . - . ID=CDS1;locus_tag=Rv1625c;product=Membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1828180 1828797 . + . ID=CDS1;locus_tag=Rv1626;product=Probable two-component system transcriptional regulator;note=FunctionalCategory: regulatory proteins chr1 CDS 1828865 1830073 . - . ID=CDS1;locus_tag=Rv1627c;product=Probable nonspecific lipid-transfer protein;note=FunctionalCategory: lipid metabolism chr1 CDS 1830070 1830561 . - . ID=CDS1;locus_tag=Rv1628c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1830665 1833379 . + . ID=CDS1;locus_tag=Rv1629;product=Probable DNA polymerase I PolA;note=FunctionalCategory: information pathways chr1 CDS 1833542 1834987 . + . ID=CDS1;locus_tag=Rv1630;product=30S ribosomal protein S1 RpsA;note=FunctionalCategory: information pathways chr1 CDS 1835013 1836236 . + . ID=CDS1;locus_tag=Rv1631;product=Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1836387 1836830 . - . ID=CDS1;locus_tag=Rv1632c;product=putative cytidylyl-2-hydroxypropylphosphonate hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3exmA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3exmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3exmA chr1 CDS 1837012 1839171 . + . ID=CDS1;locus_tag=Rv1633;product=Probable excinuclease ABC (subunit B - helicase) UvrB;note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1839168 1840583 . + . ID=CDS1;locus_tag=Rv1634;product=Possible drug efflux membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1840572 1842242 . - . ID=CDS1;locus_tag=Rv1635c;product=Probable mannosyltransferase. Probable conserved transmembrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1842451 1842891 . + . ID=CDS1;locus_tag=Rv1636;gene=uspA;product=universal stress protein family protein;Experiment=DESCRIPTION:affinity chromatography, mass spectrometry, isothermal titration calorimetry (ITC), crystallization [PMID: 25802331],Experiment=DESCRIPTION:protein isolation and precipitation, 2D-gel electrophoresis, in-gel digestion and mass spectrometry [PMID: 27895634]/inference:ab initio prediction:InterProScan [PMID: 27895634]/inference:ab initio prediction:Molecular docking [PMID: 27895634]/note:FunctionalCategory: virulence, detoxification, adaptation/note:binds cAMP and ATP [PMID: 25802331]/note:lower affinity for ATP binding than for cAMP [PMID: 25802331]/note:over expressed in amikacin and kanamycin resistant isolates and the conserved domain of this gene is predicted to interact with these drugs [PMID: 27895634] chr1 CDS 1842898 1843575 . - . ID=CDS1;locus_tag=Rv1637c;product=Conserved protein/putative thiolester hydrolase/putative dioxygenase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=1.13.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4chlA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2qedA,1qh5A,1xm8A,2gcuA,2p18A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0050313/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0006749/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005506/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4chlA,2qedA,2p18A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,2qedA,2p18A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2qedA,2p18A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qedA,2p18A,Ontology_term=0070221/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0070813/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0004416/note:identified by similarity of predicted tertiary structure to PDB 2qedA,1qh5A,1xm8A,2p18A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qedA,1qh5A,1xm8A,2p18A,Ontology_term=0019243/note:identified by similarity of predicted tertiary structure to PDB 2qedA,1qh5A,1xm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qedA,1qh5A,1xm8A chr1 CDS 1846459 1846659 . + . ID=CDS1;locus_tag=Rv1638;product=Probable excinuclease ABC (subunit A - DNA-binding ATPase) UvrA;note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1846716 1846973 . - . ID=CDS1;locus_tag=Rv1638A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1846989 1848458 . - . ID=CDS1;locus_tag=Rv1639c;product=Conserved hypothetical membrane protein;note=FunctionalCategory: cell wall and cell processes, Upregulated in the absence of active lysX gene [PMID: 21552395], induced and exported in vivo [PMID: 28442606] chr1 CDS 1848517 1852035 . - . ID=CDS1;locus_tag=Rv1640c;product=Lysyl-tRNA synthetase 2 LysX;note=FunctionalCategory: information pathways chr1 CDS 1852273 1852878 . + . ID=CDS1;locus_tag=Rv1641;product=Probable initiation factor if-3 InfC;note=FunctionalCategory: information pathways chr1 CDS 1852928 1853122 . + . ID=CDS1;locus_tag=Rv1642;product=50S ribosomal protein L35 RpmI;note=FunctionalCategory: information pathways chr1 CDS 1853184 1853573 . + . ID=CDS1;locus_tag=Rv1643;product=50S ribosomal protein L20 RplT;note=FunctionalCategory: information pathways chr1 CDS 1853606 1854388 . + . ID=CDS1;locus_tag=Rv1644;product=Possible 23S rRNA methyltransferase TsnR;note=FunctionalCategory: information pathways chr1 CDS 1854399 1855454 . - . ID=CDS1;locus_tag=Rv1645c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1855764 1856696 . + . ID=CDS1;locus_tag=Rv1646;gene=PE17;product=PE family protein PE17;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:found in whole-cell lysate but absent in culture filtrate and membrane fractions [PMID: 21920479] chr1 CDS 1856774 1857724 . + . ID=CDS1;locus_tag=Rv1647;product=Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1857731 1858537 . + . ID=CDS1;locus_tag=Rv1648;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1858733 1859758 . + . ID=CDS1;locus_tag=Rv1649;product=Probable phenylalanyl-tRNA synthetase, alpha chain PheS;note=FunctionalCategory: information pathways chr1 CDS 1859758 1862253 . + . ID=CDS1;locus_tag=Rv1650;product=Probable phenylalanyl-tRNA synthetase, beta chain PheT;note=FunctionalCategory: information pathways chr1 CDS 1862347 1865382 . - . ID=CDS1;locus_tag=Rv1651c;gene=PE_PGRS30;product=PE-PGRS family protein PE_PGRS30;Experiment=DESCRIPTION:Measurement of growth kinetics, immunoblotting, immunoelectron microscopy evaluation [PMID: 21732963],Experiment=DESCRIPTION:Gene knockout and complementation, Mycobacterial infection of mice, cytotoxicity assay, immunofluorescence, microscopy [PMID: 22050772],Experiment=DESCRIPTION:Immunoblotting, immunofluorescence, confocal microscopy and image analysis [PMID: 25390359],Experiment=DESCRIPTION:Mycobacterial infection of macrophages, CFU counting, cytokine release assays [PMID: 27129781],Experiment=DESCRIPTION:Proteinase K sensitivity assay [PMID: 24530527],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Causes phenotypic changes with altered colony morphology and growth profile (smaller colony size) in M. smegmatis [PMID: 21732963]/note:Full virulence factor, increases pathogenicity in M. smegmatis [PMID: 22050772]/note:Required to block phagosome maturation, knocking out the gene results in impaired ability to survive and multiply within macrophages [PMID: 22050772]/note:Probably contributes to protein cellular localization and causes differential cellular localization during infection [PMID: 25390359]/note:Down-regulates the production of pro-inflammatory cytokines by infected macrophages and modulates macrophage cytokine response [PMID: 27129781]/note:Exposed on the mycobacterial surface through its PGRS domain [PMID: 24530527]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642] chr1 CDS 1865576 1866634 . + . ID=CDS1;locus_tag=Rv1652;product=Probable N-acetyl-gamma-glutamyl-phosphate reductase ArgC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1866631 1867845 . + . ID=CDS1;locus_tag=Rv1653;product=Probable glutamate N-acetyltransferase ArgJ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1867842 1868726 . + . ID=CDS1;locus_tag=Rv1654;product=Probable acetylglutamate kinase ArgB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1868723 1869925 . + . ID=CDS1;locus_tag=Rv1655;product=Probable acetylornithine aminotransferase ArgD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1869922 1870845 . + . ID=CDS1;locus_tag=Rv1656;product=Probable ornithine carbamoyltransferase, anabolic ArgF;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1870842 1871354 . + . ID=CDS1;locus_tag=Rv1657;product=Probable arginine repressor ArgR (AHRC);note=FunctionalCategory: regulatory proteins chr1 CDS 1871363 1872559 . + . ID=CDS1;locus_tag=Rv1658;product=Probable argininosuccinate synthase ArgG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1872639 1874051 . + . ID=CDS1;locus_tag=Rv1659;product=Probable argininosuccinate lyase ArgH;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1874160 1875221 . + . ID=CDS1;locus_tag=Rv1660;product=Chalcone synthase Pks10;note=FunctionalCategory: lipid metabolism chr1 CDS 1875304 1881684 . + . ID=CDS1;locus_tag=Rv1661;product=Probable polyketide synthase Pks7;note=FunctionalCategory: lipid metabolism chr1 CDS 1881704 1886512 . + . ID=CDS1;locus_tag=Rv1662;product=Probable polyketide synthase Pks8;note=FunctionalCategory: lipid metabolism chr1 CDS 1886512 1888020 . + . ID=CDS1;locus_tag=Rv1663;product=Probable polyketide synthase Pks17;note=FunctionalCategory: lipid metabolism chr1 CDS 1888026 1891079 . + . ID=CDS1;locus_tag=Rv1664;product=Probable polyketide synthase Pks9;note=FunctionalCategory: lipid metabolism chr1 CDS 1891226 1892287 . + . ID=CDS1;locus_tag=Rv1665;product=Chalcone synthase Pks11;note=FunctionalCategory: lipid metabolism chr1 CDS 1892270 1893562 . - . ID=CDS1;locus_tag=Rv1666c;product=Probable cytochrome P450 139 Cyp139;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1893577 1894230 . - . ID=CDS1;locus_tag=Rv1667c;product=Probable second part of macrolide-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1894224 1895342 . - . ID=CDS1;locus_tag=Rv1668c;product=Probable first part of macrolide-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1895725 1896087 . + . ID=CDS1;locus_tag=Rv1669;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1896120 1896467 . + . ID=CDS1;locus_tag=Rv1670;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1896475 1896867 . + . ID=CDS1;locus_tag=Rv1671;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1896876 1898207 . - . ID=CDS1;locus_tag=Rv1672c;product=Probable conserved integral membrane transport protein/Putative transporter;note=FunctionalCategory: cell wall and cell processes, Induced by rifampicin [PMID: 25690361], Potential phosphate transporter, identified by similarity of predicted tertiary structure to PDB 5c65A, 4gbyA, 4ybqA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c65A, 4gbyA, 4ybqA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA chr1 CDS 1898300 1899232 . - . ID=CDS1;locus_tag=Rv1673c;product=putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3isrB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3isrB,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 3isrB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3isrB chr1 CDS 1899260 1899916 . - . ID=CDS1;locus_tag=Rv1674c;product=Probable bifunctional transcriptional regulatory protein/putative thioreductase;note=FunctionalCategory: regulatory proteins, Probably contains a HTH DNA-binding domain and rhodanese domain [PMID: 25760714];EC_number=1.8.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3nt6A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3nt6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nt6A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3nt6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nt6A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3nt6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nt6A,Ontology_term=0045454/note:identified by similarity of predicted tertiary structure to PDB 3nt6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nt6A,Ontology_term=0005623/note:identified by similarity of predicted tertiary structure to PDB 3nt6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nt6A,Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 3nt6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nt6A chr1 CDS 1900241 1900975 . - . ID=CDS1;locus_tag=Rv1675c;gene=cmr;product=transcriptional regulatory protein Cmr;Experiment=DESCRIPTION:protein purification and overexpession, genome wide ChIP-seq[PMID: 26358810]/note:FunctionalCategory: regulatory proteins/note:associated with DosR regulon chr1 CDS 1901047 1901751 . + . ID=CDS1;locus_tag=Rv1676;product=putative peroxiredoxin;Experiment=DESCRIPTION:recombinant DNA coexpression study in vitro, mass spectrometry, microarray [PMID: 20060836]/note:FunctionalCategory: conserved hypotheticals/note:interacts with a disulfide bond forming protein (DsbF) transcribed from the same operon;EC_number=1.11.1.15 chr1 CDS 1901748 1902296 . + . ID=CDS1;locus_tag=Rv1677;product=Probable conserved lipoprotein DsbF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1902397 1903299 . + . ID=CDS1;locus_tag=Rv1678;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1903299 1904420 . + . ID=CDS1;locus_tag=Rv1679;product=Possible acyl-CoA dehydrogenase FadE16;note=FunctionalCategory: lipid metabolism chr1 CDS 1904429 1905253 . + . ID=CDS1;locus_tag=Rv1680;product=Putative phosphonate transporter component;note=FunctionalCategory: conserved hypotheticals, identified by similarity of predicted tertiary structure to PDB 3p7iA, 3n5lA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3p7iA, 3n5lA chr1 CDS 1905250 1906242 . + . ID=CDS1;locus_tag=Rv1681;product=Possible molybdopterin biosynthesis protein MoeX;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1906403 1907320 . + . ID=CDS1;locus_tag=Rv1682;product=Probable coiled-coil structural protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1907597 1910593 . + . ID=CDS1;locus_tag=Rv1683;product=Possible bifunctional enzyme/ long-chain acyl-CoA synthase and lipase.;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1910586 1910810 . + . ID=CDS1;locus_tag=Rv1684;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1910776 1911399 . - . ID=CDS1;locus_tag=Rv1685c;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0043565/note:identified by similarity of predicted tertiary structure to PDB 3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bcgA,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bcgA,Ontology_term=0042493/note:identified by similarity of predicted tertiary structure to PDB 3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bcgA,Ontology_term=0008144/note:identified by similarity of predicted tertiary structure to PDB 3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bcgA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2np5A,3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np5A,3bcgA,Ontology_term=0045892/note:identified by similarity of predicted tertiary structure to PDB 3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bcgA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2np5A,3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np5A,3bcgA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bcgA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2np5A,3bcgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2np5A,3bcgA chr1 CDS 1911401 1912081 . - . ID=CDS1;locus_tag=Rv1686c;product=Probable conserved integral membrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1912153 1912920 . - . ID=CDS1;locus_tag=Rv1687c;product=Probable conserved ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1912979 1913590 . + . ID=CDS1;locus_tag=Rv1688;product=Possible 3-methyladenine DNA glycosylase Mpg;note=FunctionalCategory: information pathways chr1 CDS 1913602 1914876 . + . ID=CDS1;locus_tag=Rv1689;product=Probable tyrosyl-tRNA synthase TyrS (TYRRS);note=FunctionalCategory: information pathways chr1 CDS 1915527 1915910 . + . ID=CDS1;locus_tag=Rv1690;product=Probable lipoprotein LprJ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1915949 1916701 . + . ID=CDS1;locus_tag=Rv1691;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1916698 1917759 . + . ID=CDS1;locus_tag=Rv1692;product=Probable phosphatase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1917756 1917932 . + . ID=CDS1;locus_tag=Rv1693;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1917940 1918746 . + . ID=CDS1;locus_tag=Rv1694;product=2'-O-methyltransferase TlyA;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1918746 1919669 . + . ID=CDS1;locus_tag=Rv1695;product=Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1919683 1921446 . + . ID=CDS1;locus_tag=Rv1696;product=Probable DNA repair protein RecN (recombination protein N);note=FunctionalCategory: information pathways chr1 CDS 1921542 1922723 . + . ID=CDS1;locus_tag=Rv1697;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1922745 1923689 . + . ID=CDS1;locus_tag=Rv1698;gene=mctB;product=Copper resistance protein/Putative porin MctB;Experiment=DESCRIPTION:In vitro mutant construction, metal susceptibility assays, copper accumulation assay, in vivo,Experiment=DESCRIPTION:Gene overexpression, protein purification via Bradford assay, lipid bilayer/inference:profile:JPred 3, TMHMM 2.0 [PMID: 18434314]/inference:ab initio prediction: Chem3D Pro 8.0, Chimera [PMID: 18434314]/note:FunctionalCategory: cell wall and cell processes/note:Required for full virulence of Mtb [PMID: 21205886]/note:Involved in transport [PMID: 18434314]/note:Possibly contributes to fluoroquinolone transport [PMID: 23755283]/note:Copper sensitive outer membrane channel protein [PMID: 21205886]/note:Down-regulated under nutrient starvation [PMID: 23755283] chr1 CDS 1923829 1925589 . + . ID=CDS1;locus_tag=Rv1699;product=Probable CTP synthase PyrG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1925582 1926205 . + . ID=CDS1;locus_tag=Rv1700;product=NUDIX hydrolase;note=FunctionalCategory: information pathways chr1 CDS 1926202 1927137 . + . ID=CDS1;locus_tag=Rv1701;product=Probable integrase/recombinase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1927211 1928575 . - . ID=CDS1;locus_tag=Rv1702c;product=Putative Antigen;Experiment=ELISPOT, Whole blood Assay, T-cell Depletion assay, Fc Receptor Blocking Assay, Phagocytosis by Flow Cytometry, Human Antibodies Isotyping Assay [PMID: 28438994],Experiment=DESCRIPTION:ChIP-seq [PMID: 22528497]/note:FunctionalCategory: insertion seqs and phages/note:Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 22528497] chr1 CDS 1929131 1929721 . - . ID=CDS1;locus_tag=Rv1703c;product=Probable catechol-O-methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1929786 1931456 . - . ID=CDS1;locus_tag=Rv1704c;product=Probable D-serine/alanine/glycine transporter protein CycA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1931497 1932654 . - . ID=CDS1;locus_tag=Rv1705c;gene=PPE22;product=T cell antigen/PPE family protein PPE22;Experiment=DESCRIPTION:ex vivo interferon-gamma ELISPOT assay [PMID: 26277695],Experiment=DESCRIPTION:protein expression and purification, indirect ELISA [PMID: 20690665],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:90% similar to amino acid sequence of PPE25 [PMID: 22520463]/note:differentially expressed by plumbagin [DOI:10.1007/s11274-011-0689-3]/note:contains GlnR (regulator involved in nitrogen response) binding site [PMID: 26077160]/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection. [PMID: 21085642] chr1 CDS 1932694 1933878 . - . ID=CDS1;locus_tag=Rv1706c;gene=PPE23;product=PPE family protein PPE23;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:differentially expressed by plumbagin [DOI:10.1007/s11274-011-0689-3]/note:regulated by Rv1404 [PMID: 26615221]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 1934482 1934649 . - . ID=CDS1;locus_tag=Rv1706A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1934882 1936342 . + . ID=CDS1;locus_tag=Rv1707;product=Probable conserved transmembrane protein/putative sulfate transport protein;note=FunctionalCategory: cell wall and cell processes;Ontology_term=0015116/note:identified by similarity of predicted tertiary structure to PDB 5da0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5da0A,Ontology_term=1902358/note:identified by similarity of predicted tertiary structure to PDB 5da0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5da0A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 5da0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5da0A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 5da0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5da0A,Ontology_term=0008272/note:identified by similarity of predicted tertiary structure to PDB 5da0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5da0A chr1 CDS 1936360 1937316 . + . ID=CDS1;locus_tag=Rv1708;product=Putative initiation inhibitor protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1937313 1938149 . + . ID=CDS1;locus_tag=Rv1709;product=Possible segregation and condensation protein ScpA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1938146 1938841 . + . ID=CDS1;locus_tag=Rv1710;product=Possible segregation and condensation protein ScpB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1938838 1939602 . + . ID=CDS1;locus_tag=Rv1711;product=Putative 23S rRNA pseudouridine(2604) synthase;note=FunctionalCategory: conserved hypotheticals;EC_number=5.4.99.21 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3dh3B/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0031119/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0009451/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0000455/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0016866/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0001522/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0009982/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 3dh3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dh3B chr1 CDS 1939599 1940291 . + . ID=CDS1;locus_tag=Rv1712;product=Cytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1940288 1941679 . + . ID=CDS1;locus_tag=Rv1713;product=Probable GTP-binding protein EngA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1941853 1942665 . + . ID=CDS1;locus_tag=Rv1714;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1942659 1943573 . + . ID=CDS1;locus_tag=Rv1715;product=Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD);note=FunctionalCategory: lipid metabolism chr1 CDS 1943576 1944406 . + . ID=CDS1;locus_tag=Rv1716;product=putative linear amide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4cobA,4co9A,4cogA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0043420/note:identified by similarity of predicted tertiary structure to PDB 4cobA,4co9A,4cogA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cobA,4co9A,4cogA,Ontology_term=0019441/note:identified by similarity of predicted tertiary structure to PDB 4cobA,4co9A,4cogA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cobA,4co9A,4cogA,Ontology_term=0004328/note:identified by similarity of predicted tertiary structure to PDB 4cobA,4co9A,4cogA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cobA,4co9A,4cogA,Ontology_term=0006569/note:identified by similarity of predicted tertiary structure to PDB 4cobA,4co9A,4cogA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cobA,4co9A,4cogA,Ontology_term=0004061/note:identified by similarity of predicted tertiary structure to PDB 4cobA,4co9A,4cogA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cobA,4co9A,4cogA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4cobA,4co9A,4cogA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cobA,4co9A,4cogA chr1 CDS 1944406 1944756 . + . ID=CDS1;locus_tag=Rv1717;product=putative dioxygenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.13.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2h0vA,2phdD,1h1iB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008127/note:identified by similarity of predicted tertiary structure to PDB 2h0vA,1h1iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2h0vA,1h1iB,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2h0vA,1h1iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2h0vA,1h1iB,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2h0vA,2phdD,1h1iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2h0vA,2phdD,1h1iB,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2h0vA,2phdD,1h1iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2h0vA,2phdD,1h1iB,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 2h0vA,2phdD,1h1iB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2h0vA,2phdD,1h1iB chr1 CDS 1944809 1945627 . + . ID=CDS1;locus_tag=Rv1718;product=Probable 3-keto-5-aminohexanoate cleavage enzyme/probable carbon-carbon lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.1.-.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4nnaA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.3.1.247 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:2y7dA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4nnaA,2y7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nnaA,2y7dA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4nnaA,2y7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nnaA,2y7dA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4nnaA,2y7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nnaA,2y7dA,Ontology_term=0019475/note:identified by similarity of predicted tertiary structure to PDB 4nnaA,2y7dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nnaA,2y7dA chr1 CDS 1945641 1946420 . + . ID=CDS1;locus_tag=Rv1719;product=Probable transcriptional regulatory protein/putative transcriptional regulator;note=FunctionalCategory: regulatory proteins, Possible IclR family transcriptional factor [DOI:10.1039/C6RA07733A] [PMID: 22382436], Upregulated under manganese (Mn) deficiency [PMID: 26337157];Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 5tjjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tjjA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 5tjjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tjjA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 5tjjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tjjA chr1 CDS 1947030 1947419 . - . ID=CDS1;locus_tag=Rv1720c;product=Possible toxin VapC12;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1947416 1947643 . - . ID=CDS1;locus_tag=Rv1721c;product=Possible antitoxin VapB12;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1947861 1949345 . + . ID=CDS1;locus_tag=Rv1722;product=Possible carboxylase;note=FunctionalCategory: lipid metabolism chr1 CDS 1949342 1950589 . + . ID=CDS1;locus_tag=Rv1723;product=Probable hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1950632 1951051 . - . ID=CDS1;locus_tag=Rv1724c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1951041 1951751 . - . ID=CDS1;locus_tag=Rv1725c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1951852 1953237 . + . ID=CDS1;locus_tag=Rv1726;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1953270 1953839 . + . ID=CDS1;locus_tag=Rv1727;product=putative thiol-dependent DinB-like metalloenzyme;note=FunctionalCategory: conserved hypotheticals, identified by similarity of predicted tertiary structure to PDB 2nsgA,2nsfA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsgA,2nsfA/note:Shares the four-helix up-down-down-up bundle, salt-bridge domain-linking residues, metal-coordinating histidine triad, and predicted metal-binding site characteristic of DinB family metalloenzymes/note:Has the thiol-interacting Trp and Arg residues of the catalytic center conserved/note:potential mycothiol-dependent S-transferase” (EC 2.-.-.-) chr1 CDS 1953864 1954634 . - . ID=CDS1;locus_tag=Rv1728c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1954631 1955569 . - . ID=CDS1;locus_tag=Rv1729c;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 1955692 1957245 . - . ID=CDS1;locus_tag=Rv1730c;product=Possible penicillin-binding protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1957677 1959233 . + . ID=CDS1;locus_tag=Rv1731;product=Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1959243 1959791 . - . ID=CDS1;locus_tag=Rv1732c;product=Conserved protein/putative peroxidase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.11.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.8.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2b5yA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0042262/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0006457/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0019207/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0032843/note:identified by similarity of predicted tertiary structure to PDB 2bmxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,Ontology_term=0034605/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0050821/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0005844/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0042744/note:identified by similarity of predicted tertiary structure to PDB 1qmvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,Ontology_term=0008379/note:identified by similarity of predicted tertiary structure to PDB 1qmvA,3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,3sbcA,Ontology_term=0051409/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,Ontology_term=0090344/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0042981/note:identified by similarity of predicted tertiary structure to PDB 1qmvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,Ontology_term=0034599/note:identified by similarity of predicted tertiary structure to PDB 1qmvA,3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,3sbcA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1qmvA,1n8jT,3sbcA,2b5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1qmvA,1n8jT,3sbcA,2b5yA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1qmvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 2bmxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,Ontology_term=0008785/note:identified by similarity of predicted tertiary structure to PDB 2bmxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,Ontology_term=0051082/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0061077/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,4k1fA,3drnA,3ixrA,3ztlA,1n8jT,3sbcA,2b5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,4k1fA,3drnA,3ixrA,3ztlA,1n8jT,3sbcA,2b5yA,Ontology_term=1903206/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0043066/note:identified by similarity of predicted tertiary structure to PDB 1qmvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,Ontology_term=0006111/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0043022/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0033194/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0060548/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0016209/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA,Ontology_term=0052059/note:identified by similarity of predicted tertiary structure to PDB 2bmxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bmxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,Ontology_term=0001302/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0045454/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA,Ontology_term=0006979/note:identified by similarity of predicted tertiary structure to PDB 1qmvA,1n8jT/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,1n8jT,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,3drnA,3ixrA,1qmvA,3ztlA,1n8jT,3sbcA,2b5yA,Ontology_term=0052060/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,Ontology_term=0042325/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0051258/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0000077/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,1qmvA,3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,1qmvA,3sbcA,Ontology_term=0005623/note:identified by similarity of predicted tertiary structure to PDB 4k1fA,3drnA,3ixrA,3ztlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k1fA,3drnA,3ixrA,3ztlA,Ontology_term=0051920/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,1qmvA,3ztlA,1n8jT,3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,4k1fA,1zyeL,2pn8A,1qmvA,3ztlA,1n8jT,3sbcA,Ontology_term=0019430/note:identified by similarity of predicted tertiary structure to PDB 1qmvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qmvA,Ontology_term=0071447/note:identified by similarity of predicted tertiary structure to PDB 3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sbcA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,3sbcA,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 2bmxB,1xvwB,4k1fA,1qmvA,3ztlA,1n8jT,3sbcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bmxB,1xvwB,4k1fA,1qmvA,3ztlA,1n8jT,3sbcA chr1 CDS 1959855 1960487 . - . ID=CDS1;locus_tag=Rv1733c;product=T-cell Antigen;Experiment=DESCRIPTION:IFN-γ ELISA,in vivo infection, in vivo cytotoxicity assay [PMID: 26202436]/note:FunctionalCategory: cell wall and cell processes/note:Potential vaccine candidate [PMID: 24498941]/note:Latency antigen which is highly expressed in dormant conditions [PMID: 26202436]/note:Frequently recognized by T cell response in latent TB infected patients [PMID: 28255560]/note:Induces strong IFN-gamma responses in skin test positive individuals, suggesting immune response against this antigen may contribute to the control of latent Mtb infection. [PMID: 27780773]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 1960774 1961016 . - . ID=CDS1;locus_tag=Rv1734c;product=putative acyltransferase;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=2.3.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3rqcA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 3rqcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rqcA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3rqcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rqcA chr1 CDS 1961291 1961788 . - . ID=CDS1;locus_tag=Rv1735c;product=Immunogenic Antigen;Experiment=DESCRIPTION:Whole-blood assay, IFN-γ ELISA [PMID: 19553548]/note:FunctionalCategory: cell wall and cell processes/note:Possible dosR regulon-encoded antigen [PMID: 19553548]/note:Frequently recognized by T cell response in latent TB infected patients [PMID: 28255560]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 1962228 1964186 . - . ID=CDS1;locus_tag=Rv1736c;product=Probable nitrate reductase NarX;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1964183 1965370 . - . ID=CDS1;locus_tag=Rv1737c;product=Possible nitrate/nitrite transporter NarK2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1965657 1965941 . + . ID=CDS1;locus_tag=Rv1738;product=Putative hibernation promoting factor;Experiment=DESCRIPTION:racemic crystallography[PMID: 25831534]/note:FunctionalCategory: conserved hypotheticals/note:structurally similar to bacterial hibernation factors [PMID: 25831534]/note:contributes to shutdown of ribosomal protein synthesis [PMID: 25831534]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 1965955 1967637 . - . ID=CDS1;locus_tag=Rv1739c;product=Probable sulfate-transport transmembrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1967705 1967917 . + . ID=CDS1;locus_tag=Rv1740;product=Possible antitoxin VapB34;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1967917 1968165 . + . ID=CDS1;locus_tag=Rv1741;product=Possible toxin VapC34. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 1968173 1968910 . + . ID=CDS1;locus_tag=Rv1742;product=Unknown protein;note=FunctionalCategory: unknown chr1 CDS 1969004 1970704 . + . ID=CDS1;locus_tag=Rv1743;product=Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E);note=FunctionalCategory: regulatory proteins chr1 CDS 1970989 1971390 . - . ID=CDS1;locus_tag=Rv1744c;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1971380 1971991 . - . ID=CDS1;locus_tag=Rv1745c;product=Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1972138 1973568 . + . ID=CDS1;locus_tag=Rv1746;product=Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F);note=FunctionalCategory: regulatory proteins chr1 CDS 1973630 1976227 . + . ID=CDS1;locus_tag=Rv1747;product=Probable conserved transmembrane ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1976600 1977331 . + . ID=CDS1;locus_tag=Rv1748;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1977328 1977885 . - . ID=CDS1;locus_tag=Rv1749c;product=Possible integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1977969 1979567 . - . ID=CDS1;locus_tag=Rv1750c;product=Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 1979621 1981003 . + . ID=CDS1;locus_tag=Rv1751;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1981130 1981579 . + . ID=CDS1;locus_tag=Rv1752;product=putative CH-CH dehydrogenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.3.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2poqX/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0047115/note:identified by similarity of predicted tertiary structure to PDB 2poqX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2poqX,Ontology_term=0047837/note:identified by similarity of predicted tertiary structure to PDB 2poqX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2poqX,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2poqX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2poqX,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2poqX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2poqX chr1 CDS 1981614 1984775 . - . ID=CDS1;locus_tag=Rv1753c;gene=PPE24;product=PPE family protein PPE24;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 1984979 1986670 . - . ID=CDS1;locus_tag=Rv1754c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1986854 1987696 . - . ID=CDS1;locus_tag=Rv1755c;product=Probable phospholipase C 4 (fragment) PlcD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 1987745 1988731 . - . ID=CDS1;locus_tag=Rv1756c;product=Putative transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1988680 1989006 . - . ID=CDS1;locus_tag=Rv1757c;product=Putative transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1989042 1989566 . + . ID=CDS1;locus_tag=Rv1758;product=Probable cutinase Cut1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1989833 1992577 . - . ID=CDS1;locus_tag=Rv1759c;gene=wag22;product=Antigen/PE-PGRS family protein Wag22;Experiment=DESCRIPTION:Real-time PCR, immunoelectron microscopy, in vivo interferon-gamma production via stimulation of lymph nodes, lungs and spleen in mouse, ELISA [PMID: 17399860],Experiment=DESCRIPTION:Southern blot assay, recombinant expression and purification, SDS-page and immunoblotting [PMID: 10627046],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=EXISTENCE:2-dimensional gel electrophoresis, liquid chromatography mass spectrometry [PMID: 17443846]/note:FunctionalCategory: PE/PPE/note:Expressed during stable chronic infection and localized in the cell wall of phagocytosed bacilli [PMID: 17399860]/note:Fibronectin (Fn)-binding protein [PMID: 10627046]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642]/note:Probably secreted, found in culture filtrate [PMID: 17443846] chr1 CDS 1993153 1994661 . + . ID=CDS1;locus_tag=Rv1760;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 1994671 1995054 . - . ID=CDS1;locus_tag=Rv1761c;product=Possible exported protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 1995054 1995842 . - . ID=CDS1;locus_tag=Rv1762c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 1996152 1996478 . + . ID=CDS1;locus_tag=Rv1763;product=Putative transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1996427 1997413 . + . ID=CDS1;locus_tag=Rv1764;product=Putative transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 1997418 1998515 . - . ID=CDS1;locus_tag=Rv1765c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 1999142 1999357 . - . ID=CDS1;locus_tag=Rv1765A;product=Putative transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 1999737 2000006 . + . ID=CDS1;locus_tag=Rv1766;product=Conserved protein/putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 4m1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4m1pA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4m1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4m1pA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 4m1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4m1pA chr1 CDS 2000074 2000433 . + . ID=CDS1;locus_tag=Rv1767;product=Conserved protein/Probable Peroxiredoxin;note=FunctionalCategory: conserved hypotheticals;EC_number=1.11.1.15 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:5dikA,1p8cC/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 5dikA,1p8cC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dikA,1p8cC,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 5dikA,1p8cC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dikA,1p8cC,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 5dikA,1p8cC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dikA,1p8cC,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 5dikA,1p8cC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dikA,1p8cC,Ontology_term=0016209/note:identified by similarity of predicted tertiary structure to PDB 5dikA,1p8cC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dikA,1p8cC,Ontology_term=0051920/note:identified by similarity of predicted tertiary structure to PDB 5dikA,1p8cC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dikA,1p8cC chr1 CDS 2000614 2002470 . + . ID=CDS1;locus_tag=Rv1768;gene=PE_PGRS31;product=Probable T-cell antigen/PE-PGRS family protein PE_PGRS31;Experiment=DESCRIPTION:interferon-gamma release assay, ELISPOT, ELISA [PMID: 26318635],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:differentially regulated under hypoxic conditions [PMID: 27328747]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 2002626 2003870 . + . ID=CDS1;locus_tag=Rv1769;product=T-cell antigen/probable serine hydrolase/T-cell antigen/putative aldehyde-lyase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625],Experiment=DESCRIPTION:Enzyme-linked ImmunoSpot (ELISPOT) assay [PMID: 15102765]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.-,EC_number=4.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4v15A/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 2003878 2005164 . + . ID=CDS1;locus_tag=Rv1770;product=probable serine hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.- chr1 CDS 2005161 2006447 . + . ID=CDS1;locus_tag=Rv1771;product=L-gulono-1,4-lactone dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2006636 2006947 . + . ID=CDS1;locus_tag=Rv1772;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2007020 2007766 . - . ID=CDS1;locus_tag=Rv1773c;product=Probable transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins, Possible IclR family transcriptional factor [DOI:10.1039/C6RA07733A] [PMID: 17194626], probably induced by inh and ethobromide [PMID: 16246625];Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 1mkmB2,1mkmB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mkmB2,1mkmB,Ontology_term=0046278/note:identified by similarity of predicted tertiary structure to PDB 2ia2A2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ia2A2,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3r4kA2,2ia2A2,5tjjA2,1mkmB2,1mkmB,2o0yC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r4kA2,2ia2A2,5tjjA2,1mkmB2,1mkmB,2o0yC,Ontology_term=0045892/note:identified by similarity of predicted tertiary structure to PDB 1mkmB2,1mkmB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mkmB2,1mkmB,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1mkmB2,3r4kA2,5tjjA2,1mkmB,2o0yC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mkmB2,3r4kA2,5tjjA2,1mkmB,2o0yC,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3r4kA2,2ia2A2,5tjjA2,1mkmB2,1mkmB,2o0yC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r4kA2,2ia2A2,5tjjA2,1mkmB2,1mkmB,2o0yC,Ontology_term=0045893/note:identified by similarity of predicted tertiary structure to PDB 2ia2A2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ia2A2 chr1 CDS 2007832 2009172 . + . ID=CDS1;locus_tag=Rv1774;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2009172 2009990 . + . ID=CDS1;locus_tag=Rv1775;product=putative 3-oxo-carboxylic acid hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.7.1.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3hwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hwpA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3hwpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hwpA/note:Has phloroglucinol moiety recognition residues conserved (Y125, H118 and H214 in P. fluorescens 2,4-diacetylphloroglucinol hydrolase [PMID: 30784195])/note:May act on substrate(s) containing phloroglucinol moiety/note:Has Zinc-coordinating residues conserved chr1 CDS 2009995 2010555 . - . ID=CDS1;locus_tag=Rv1776c;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3bniA,5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bniA,5d1wA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3bniA,5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bniA,5d1wA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3bniA,5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bniA,5d1wA,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 3bniA,5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bniA,5d1wA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 3bniA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bniA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3bniA,5d1wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bniA,5d1wA chr1 CDS 2010656 2011960 . + . ID=CDS1;locus_tag=Rv1777;product=Probable cytochrome P450 144 Cyp144;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2012081 2012530 . - . ID=CDS1;locus_tag=Rv1778c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2012686 2014479 . - . ID=CDS1;locus_tag=Rv1779c;product=Possible integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2014699 2015262 . + . ID=CDS1;locus_tag=Rv1780;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2015302 2017476 . - . ID=CDS1;locus_tag=Rv1781c;product=Probable 4-alpha-glucanotransferase MalQ (amylomaltase) (disproportionating enzyme) (D-enzyme);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2017740 2019260 . + . ID=CDS1;locus_tag=Rv1782;product=ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2019257 2023432 . + . ID=CDS1;locus_tag=Rv1783;product=ESX conserved component EccC5. ESX-5 type VII secretion system protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2023447 2024628 . - . ID=CDS1;locus_tag=Rv1785c;product=Probable cytochrome P450 143 Cyp143;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2024828 2025031 . + . ID=CDS1;locus_tag=Rv1786;product=Probable ferredoxin;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2025301 2026398 . + . ID=CDS1;locus_tag=Rv1787;gene=PPE25;product=PPE family protein PPE25;Experiment=DESCRIPTION:Gene knockout and complementation, macrophage infection assays, mouse infection studies [PMID: 22340629]/note:FunctionalCategory: PE/PPE/note:Putatively expressed during macrophage infection and putatively prevents phagosome lysosome fusion [PMID: 15760454]/note:Possible ESX-5 associated protein [PMID: 22520463]/note:found to be attenuated in macrophages and in immune-deficient mouse infection model [PMID: 22340629]/note:Possibly involved in the ESX-5 secretion machinery [PMID: 22340629]/note:Deletion of a region of five genes in the ESX-5 locus, Rv1787-Rv1791 (ppe25-pe19), attenuated M.tb growth in lungs and spleen of intravenously infected SCID mice [PMID: 22340629] chr1 CDS 2026477 2026776 . + . ID=CDS1;locus_tag=Rv1788;gene=PE18;product=T cell antigen/PE family protein PE18;Experiment=DESCRIPTION:ex vivo interferon-gamma ELISPOT assay [PMID: 26277695]/note:FunctionalCategory: PE/PPE/note:differentially regulated under hypoxic conditions [PMID: 27328747]/note:predicted to be involved in the regulation of latency/dormancy in M. tuberculosis [PMID: 23146828]/note:ESX-5 associated protein involved in virulence [PMID: 22520463] chr1 CDS 2026790 2027971 . + . ID=CDS1;locus_tag=Rv1789;gene=PPE26;product=Probable Antigen/PPE family protein PPE26;Experiment=DESCRIPTION:antigen identification and purification, transformation into E. Coli, protein array serological screening, ELISA [PMID: 20719988],Experiment=DESCRIPTION:iTRAQ labeling, infection of macrophages, LC-MS/MS, measurement of cytokines via Sandwich ELISA, RT-PCR, immunoprecipitation, Toll-like receptor binding assay, flow cytometry, western blotting, mixed lymphocyte reaction assay, analysis of Th1 response in vivo [PMID: 26439698],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:located in the cell membrane [PMID: 21920479,21261938]/note:not found in the culture filtrate or whole-cell lysate [PMID: 21920479]/note:binds to TLR2 and activates MAPKs and NF-κB signaling pathways [PMID: 26439698]/note:activates macrophages to induce the proliferation of naive T cells towards a Th1 phenotype by binding to TLR2 and drives Th1 immune response [PMID: 26439698]/note:mentioned as a member of the ESX-5-encoded PPE protein family [PMID: 22520463,27351106]/note:modulates cytokine secretion in mouse macrophages [PMID: 27351106]/note:vaccine candidate, shown to reduce bacterial burdens in the lungs of mice [PMID: 23906890] chr1 CDS 2028425 2029477 . + . ID=CDS1;locus_tag=Rv1790;gene=PPE27;product=PPE family protein PPE27;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642]/note:Down-regulated on treatment with glycine/lysozyme [PMID: 23195184]/note:Possibly inhibited/down-regulated by dosT [PMID: 26270051] chr1 CDS 2029904 2030203 . + . ID=CDS1;locus_tag=Rv1791;gene=PE19;product=Antigen/PE family protein PE19;Experiment=DESCRIPTION: Ex vivo interferon-gamma ELISPOT assay [PMID: 26277695]/note:ESX-5 associated protein, disruption of ESX-5 associated protein (PPE25-PE19) resulted in an attenuated phenotype in murine macrophages [PMID: 22340629]/note:possibly involved in cell wall assembly [PMID: 22340629]/note:no EsxN specific band detected in the culture supernatant of a ppe25-pe19 region knockout mutant, suggesting a role of pe19 in EsxN export [PMID: 22340629]/note:FunctionalCategory: PE/PPE chr1 CDS 2030347 2030643 . + . ID=CDS1;locus_tag=Rv1792;product=ESAT-6 like protein EsxM;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2030694 2030978 . + . ID=CDS1;locus_tag=Rv1793;product=Putative ESAT-6 like protein EsxN (ESAT-6 like protein 5);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2031066 2031968 . + . ID=CDS1;locus_tag=Rv1794;product=probable serine hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.- chr1 CDS 2032240 2033751 . + . ID=CDS1;locus_tag=Rv1795;product=ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2033729 2035486 . + . ID=CDS1;locus_tag=Rv1796;product=Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2035483 2036703 . + . ID=CDS1;locus_tag=Rv1797;product=ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2036700 2038532 . + . ID=CDS1;locus_tag=Rv1798;product=ESX conserved component EccA5. ESX-5 type VII secretion system protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2039159 2039350 . + . ID=CDS1;locus_tag=Rv1799;product=Probable lipoprotein LppT;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2039453 2041420 . + . ID=CDS1;locus_tag=Rv1800;gene=PPE28;product=PPE family protein PPE28;Inference=ab initio prediction:PHYRE2 [PMID: 26891364]/note:FunctionalCategory: PE/PPE/note:Identified to contain a serine α/β hydrolase domain with the pentapeptide sequence motif GxSxG/S [PMID: 26891364]/note:Identified to contain conserved Ser, Asp and His catalytic triad characteristic of lipase, esterase and cutinase activities [PMID: 21347309] chr1 CDS 2042001 2043272 . + . ID=CDS1;locus_tag=Rv1801;gene=PPE29;product=PPE family protein PPE29;Experiment=EXISTENCE:SDS-PAGE, 2-D gel electrophoresis, multi-dimensional liquid chromatography and mass spectrometry, western blot [PMID: 20825248]/note:FunctionalCategory: PE/PPE/note:Probably required for endothelial-cell invasion and/or intracellular survival, up-regulated by at least 8-fold in human brain microvascular endothelial-cell–associated vs. –unassociated Mtb bacilli [PMID: 16586367]/note:located in the cell wall [PMID: 20825248] chr1 CDS 2043384 2044775 . + . ID=CDS1;locus_tag=Rv1802;gene=PPE30;product=T cell antigen/PE family protein PPE30;Experiment=DESCRIPTION: Ex vivo interferon-gamma ELISPOT assay [PMID: 26277695],Experiment=EXISTENCE: Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Recognized in all LTBI patients when 25 patients tested [PMID: 26277695]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 2044923 2046842 . - . ID=CDS1;locus_tag=Rv1803c;gene=PE_PGRS32;product=Probable antigen/PE family protein PE_PGRS32;Experiment=DESCRIPTION:protein expression and purification, indirect ELISA [PMID: 20690665],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 2047023 2047349 . - . ID=CDS1;locus_tag=Rv1804c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2047687 2048034 . - . ID=CDS1;locus_tag=Rv1805c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2048072 2048371 . + . ID=CDS1;locus_tag=Rv1806;gene=PE20;product=PE family protein PE20;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:putatively induces T-cell responses [PMID: 20880640]/note:found in whole-cell lysate and cell membrane but absent in culture filtrate [PMID: 21920479] chr1 CDS 2048398 2049597 . + . ID=CDS1;locus_tag=Rv1807;gene=PPE31;product=Probable T-cell antigen/PPE family protein PPE31;Experiment=DESCRIPTION:ELISpot assay, triple intracellular cytokine staining (ICS) assay, in vivo cytotoxic T lymphocyte (CTL) assay [PMID: 26599077],Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry. [PMID: 21261938]/note:FunctionalCategory: PE/PPE/note:Induced tenfold during exposure to a concentration of vancomycin eight fold lower than the MIC when measured with quantitative RT-PCR [PMID: 19332811]/note:Located in the cell membrane [PMID: 21261938,21920479]/note:found in whole-cell lysate but absent in culture filtrate [PMID: 21920479]/note:pH induced (in vitro) [PMID: 18005756]/note:Required for in vivo survival of M. tuberculosis in mice [PMID: 14569030]/note:Upregulated in mutants defective in dosR response regulator [PMID: 26270051] chr1 CDS 2049921 2051150 . + . ID=CDS1;locus_tag=Rv1808;gene=PPE32;product=PPE family protein PPE32;Experiment=DESCRIPTION:protein expression, detection and localization, survival kinetics of M. smegmatis infection in macrophages, RNA extraction, cytokine assay, ELISA [PMID: 24525621],Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938]/note:FunctionalCategory: PE/PPE/note:Enhanced the survival of M.smegmatis within macrophages [PMID: 24525621]/note:Associated with the cell wall and exposed on the cell surface [PMID: 24525621]/note:Interacts with Toll-like receptor 2 and manipulates host cytokines via MAPK and NF-kB signaling pathways [PMID: 24525621]/note:Located in the cell membrane [PMID: 21261938,21920479]/note:found in whole-cell lysate but absent in culture filtrate [PMID: 21920479] chr1 CDS 2051282 2052688 . + . ID=CDS1;locus_tag=Rv1809;gene=PPE33;product=PPE family protein PPE33;Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:gel electrophoresis, liquid chromatography-mass spectrometry, label-free quantitation [PMID: 21920479],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Located in the cell membrane [PMID: 21261938, 21920479]/note:found in whole-cell lysate but absent in culture filtrate [PMID: 21920479]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642]/note:Upregulated under starvation [PMID: 24268774] chr1 CDS 2052933 2053289 . + . ID=CDS1;locus_tag=Rv1810;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2053443 2054147 . + . ID=CDS1;locus_tag=Rv1811;product=Possible Mg2+ transport P-type ATPase C MgtC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2054157 2055359 . - . ID=CDS1;locus_tag=Rv1812c;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2055681 2056112 . - . ID=CDS1;locus_tag=Rv1813c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 2056521 2057423 . + . ID=CDS1;locus_tag=Rv1814;product=Membrane-bound C-5 sterol desaturase Erg3 (sterol-C5-desaturase);note=FunctionalCategory: lipid metabolism chr1 CDS 2057528 2058193 . + . ID=CDS1;locus_tag=Rv1815;product=Conserved protein/putative serine endopeptidase;Experiment=DESCRIPTION:microarray analysis, Real-time PCR and mRNA quantitation [PMID: 15375142]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be regulated by sigD;EC_number=3.4.21.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3uwjH,3bn9B,3e0nB,1jwtA,1qy6A,2vntC,1a0lA,4jcnA,1hpgA,1ym0A,1gbiA,1fizA,4iw4E,1z8gA,3govB,1yc0A,1hylA,1bmlA,2ea3A,1ekbB,2qa9E,1a5iA,2sfaA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004252/note:identified by similarity of predicted tertiary structure to PDB 3uwjH,3bn9B,3e0nB,1jwtA,1qy6A,2vntC,1a0lA,4jcnA,1hpgA,1ym0A,1gbiA,1fizA,4iw4E,1z8gA,3govB,1yc0A,1hylA,1bmlA,2ea3A,1ekbB,2qa9E,1a5iA,2sfaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uwjH,3bn9B,3e0nB,1jwtA,1qy6A,2vntC,1a0lA,4jcnA,1hpgA,1ym0A,1gbiA,1fizA,4iw4E,1z8gA,3govB,1yc0A,1hylA,1bmlA,2ea3A,1ekbB,2qa9E,1a5iA,2sfaA,Ontology_term=0007596/note:identified by similarity of predicted tertiary structure to PDB 3uwjH,1jwtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uwjH,1jwtA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1z8gA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z8gA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1a0lA,1hpgA,1hylA,2sfaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0lA,1hpgA,1hylA,2sfaA,Ontology_term=0016310/note:identified by similarity of predicted tertiary structure to PDB 1ym0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym0A,Ontology_term=0016301/note:identified by similarity of predicted tertiary structure to PDB 1ym0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym0A,Ontology_term=0030574/note:identified by similarity of predicted tertiary structure to PDB 1hylA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1hylA,Ontology_term=0031012/note:identified by similarity of predicted tertiary structure to PDB 1a0lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0lA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1jwtA,1a0lA,1hylA,2sfaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jwtA,1a0lA,1hylA,2sfaA,Ontology_term=0005509/note:identified by similarity of predicted tertiary structure to PDB 3uwjH,1jwtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uwjH,1jwtA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1a0lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0lA,Ontology_term=0070008/note:identified by similarity of predicted tertiary structure to PDB 1z8gA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z8gA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3uwjH,3bn9B,3e0nB,1jwtA,1qy6A,2vntC,1a0lA,4jcnA,1hpgA,1ym0A,1gbiA,1fizA,4iw4E,1z8gA,3govB,1yc0A,1hylA,1bmlA,2ea3A,1ekbB,2qa9E,1a5iA,2sfaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uwjH,3bn9B,3e0nB,1jwtA,1qy6A,2vntC,1a0lA,4jcnA,1hpgA,1ym0A,1gbiA,1fizA,4iw4E,1z8gA,3govB,1yc0A,1hylA,1bmlA,2ea3A,1ekbB,2qa9E,1a5iA,2sfaA,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 1a0lA,1hpgA,1hylA,2sfaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a0lA,1hpgA,1hylA,2sfaA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1ym0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym0A,Ontology_term=0008236/note:identified by similarity of predicted tertiary structure to PDB 1qy6A,1a0lA,4jcnA,1hpgA,1hylA,2sfaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qy6A,1a0lA,4jcnA,1hpgA,1hylA,2sfaA chr1 CDS 2058256 2058960 . + . ID=CDS1;locus_tag=Rv1816;product=Probable TetR family transcription factor regulator;Experiment=DESCRIPTION: Protein expression and purification in E. Coli, structural determination and refinement, Isothermal titration calorimetry for ligand binding, Fluorescence Polarization Assay for DNA binding, Electrophoretic Mobility Shift Assay [PMID: 26396194]/note:FunctionalCategory: regulatory proteins/note:Forms dimeric two-domain molecules with architecture consistent with the TetR family regulators [PMID: 26396194]/note:Able to recognize the promoter and intragenic regions of multiple mmpLs [PMID: 26396194] chr1 CDS 2059595 2061058 . + . ID=CDS1;locus_tag=Rv1817;product=Possible flavoprotein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2061178 2062674 . - . ID=CDS1;locus_tag=Rv1818c;gene=PE_PGRS33;product=PE-PGRS family protein PE_PGRS33;Experiment=DESCRIPTION:Protein expression, cell fractionation studies, fluorescence immunoblot, trypsin sensitivity assay, electron microscopy [PMID: 15101979],Experiment=DESCRIPTION:ELISA, in vitro cell proliferation assay and cytokine assay, in vitro expansion of antigen-specific CTLs, ELISPOT assay, CTL assay [PMID: 17374885],Experiment=DESCRIPTION:Immunoassays, western blot, flow cytometry cell death analysis, mitochondrial membrane potential measurements [PMID: 21081760],Experiment=DESCRIPTION:Gene knockout and complementation, mycobacterial infection and bacterial counts [PMID: 26978522],Experiment=DESCRIPTION:CaCl2 overlay assay, isothermal titration calorimetry (ITC), fluorescence and circular dichroism spectroscopy [PMID: 27483162],Experiment=DESCRIPTION:qRT-PCR, in vitro transcription run assay [PMID: 19068228]/note:FunctionalCategory: PE/PPE/note:Localized in the mycobacterial cell wall, mostly at the bacterial cell poles, where it is exposed to the extracellular milieu [PMID: 15101979]/note:Smac-dependent activation of caspases in T-cells regulate Rv1818c induced apoptosis [PMID: 17223373]/note:Short peptide fragments of this protein can induce the production of IFN-y by CD8+ T cells in mice [PMID: 17374885]/note:Targets host mitochondria [PMID: 21081760]/note:Host cell apoptosis and necrosis levels increase during expression of this protein [PMID: 21081760]/note:Interacts with TLR2 to mediate Mycobacterium tuberculosis entry into macrophages [PMID: 26978522]/note:Interacts with TLR2 in a calcium-dependent manner [PMID: 27483162]/note:Binds Ca2+ [PMID: 27483162]/note:Transcribed from monocistronic mRNA [PMID: 19068228]/note:Expression is down-regulated in stationary phase, and upregulated in sigD mutants [PMID: 19068228]/note:Expressed during nutrient depletion and hypoxia in vivo [PMID: 16672626]/note:Transcription mediated by SigA, promoter regions is recognized by SigA [PMID: 19068228]/note:frameshift mutations in this gene impair the cell entry phenotype [PMID: 28484686]/note:inactivation of this gene causes tissue damage in murine lungs during chronic persistent TB disease stages [PMID: 28484686] chr1 CDS 2062809 2064728 . - . ID=CDS1;locus_tag=Rv1819c;product=Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2064799 2066442 . + . ID=CDS1;locus_tag=Rv1820;product=Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2066457 2068883 . + . ID=CDS1;locus_tag=Rv1821;product=Possible preprotein translocase ATPase SecA2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2069080 2069709 . + . ID=CDS1;locus_tag=Rv1822;product=Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA2 (PGP synthase) (phosphatidylglycerophosphate synthase) (3-phosphatidyl-1'-glycerol-3'phosphate synthase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2069702 2070625 . + . ID=CDS1;locus_tag=Rv1823;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2070654 2071019 . + . ID=CDS1;locus_tag=Rv1824;product=Conserved hypothetical membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2071036 2071914 . + . ID=CDS1;locus_tag=Rv1825;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2071952 2072356 . + . ID=CDS1;locus_tag=Rv1826;product=Probable glycine cleavage system H protein GcvH;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2072596 2073084 . + . ID=CDS1;locus_tag=Rv1827;gene=garA;product=Glycogen accumulation regulator (GarA) | Probable antigen/Glycogen accumulation regulator (GarA)/Probable antigen/putative phosphoric monoester hydrolase;Experiment=DESCRIPTION:in vitro recombinant protein expression, enzyme assays, pull-down assays, isothermic titration calorimetry, NMR, surface plasmon resonance [PMID: 19318624],Experiment=DESCRIPTION:gene knockout in M. smegmatis and M. tuberculosis, measurement of growth rate and nutrient requirements for knockout strain [PMID: 23962235],Experiment=DESCRIPTION:Indirect ELISA [PMID: 28337993]/note:FunctionalCategory: conserved hypotheticals/note:regulates the TCA cycle, modulates the activities of Kgd, Gdh and GltB [PMID: 19318624]/note:essential in M. tuberculosis [PMID: 23962235]/note:influences the distribution of alpha-ketoglutarate between the TCA cycle and glutamate synthesis by inhibiting KDH, activating glutamate synthesis and inhibiting glutamate degradation [PMID: 23962235]/note:deletion of this gene in M. smegmatis results in a nutrient-dependent growth defect [PMID: 23962235]/note:in garA knockout M. smegmatis strains, when using substrates that enter glycolysis (glucose and glycerol) as carbon source, growth was observed to be the same as wild-type, but using substrates that enter the TCA cycle (acetate, propionate and succinate) this strain showed little or no growth [PMID: 23962235];EC_number=3.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1mzkA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 2073081 2073824 . + . ID=CDS1;locus_tag=Rv1828;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2073943 2074437 . + . ID=CDS1;locus_tag=Rv1829;gene=cor;product=Carbon monoxide resistance gene Cor;Experiment=DESCRIPTION:Protein purification, Carbon monoxide (CO) susceptibility assays, complementation [PMID: 24255121]/note:FunctionalCategory: conserved hypotheticals/note:predicted to protect against accumulation of excess reducing equivalents chr1 CDS 2074841 2075518 . + . ID=CDS1;locus_tag=Rv1830;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2075571 2075828 . + . ID=CDS1;locus_tag=Rv1831;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2075877 2078702 . + . ID=CDS1;locus_tag=Rv1832;product=Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2078929 2079789 . - . ID=CDS1;locus_tag=Rv1833c;product=Possible haloalkane dehalogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2079830 2080696 . + . ID=CDS1;locus_tag=Rv1834;product=Probable hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2080701 2082587 . - . ID=CDS1;locus_tag=Rv1835c;product=putative carboxylic ester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.1.- (Putative);Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3idaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3idaA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1nx9A,4pf1A,3idaA,1mpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nx9A,4pf1A,3idaA,1mpxA,Ontology_term=0008239/note:identified by similarity of predicted tertiary structure to PDB 1nx9A,4pf1A,3idaA,1mpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nx9A,4pf1A,3idaA,1mpxA,Ontology_term=0050784/note:identified by similarity of predicted tertiary structure to PDB 3idaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3idaA,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 3idaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3idaA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 1nx9A,4pf1A,3idaA,1mpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nx9A,4pf1A,3idaA,1mpxA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1mpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mpxA,Ontology_term=0047658/note:identified by similarity of predicted tertiary structure to PDB 1nx9A,1mpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nx9A,1mpxA chr1 CDS 2082603 2084636 . - . ID=CDS1;locus_tag=Rv1836c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2084756 2086981 . - . ID=CDS1;locus_tag=Rv1837c;product=Malate synthase G GlcB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2087257 2087652 . - . ID=CDS1;locus_tag=Rv1838c;product=Possible toxin VapC13;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2087649 2087912 . - . ID=CDS1;locus_tag=Rv1839c;product=Possible antitoxin VapB13;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2087971 2089518 . - . ID=CDS1;locus_tag=Rv1840c;gene=PE_PGRS34;product=PE-PGRS family protein PE_PGRS34;note=FunctionalCategory: PE/PPE chr1 CDS 2089681 2090718 . - . ID=CDS1;locus_tag=Rv1841c;product=Conserved hypothetical membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2090718 2092085 . - . ID=CDS1;locus_tag=Rv1842c;product=Conserved hypothetical membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2092259 2093698 . - . ID=CDS1;locus_tag=Rv1843c;product=Probable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2093731 2095188 . - . ID=CDS1;locus_tag=Rv1844c;product=Probable 6-phosphogluconate dehydrogenase Gnd1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2095218 2096168 . - . ID=CDS1;locus_tag=Rv1845c;product=Possible sensor-transducer protein BlaR;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2096183 2096599 . - . ID=CDS1;locus_tag=Rv1846c;product=Transcriptional repressor BlaI;note=FunctionalCategory: regulatory proteins chr1 CDS 2096877 2097299 . + . ID=CDS1;locus_tag=Rv1847;product=Conserved protein/putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3s4kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3s4kA chr1 CDS 2097348 2097650 . + . ID=CDS1;locus_tag=Rv1848;product=Urease gamma subunit UreA (urea amidohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2097647 2097961 . + . ID=CDS1;locus_tag=Rv1849;product=Urease beta subunit UreB (urea amidohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2097961 2099694 . + . ID=CDS1;locus_tag=Rv1850;product=Urease alpha subunit UreC (urea amidohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2099694 2100329 . + . ID=CDS1;locus_tag=Rv1851;product=Urease accessory protein UreF;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2100340 2101014 . + . ID=CDS1;locus_tag=Rv1852;product=Urease accessory protein UreG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2101022 2101648 . + . ID=CDS1;locus_tag=Rv1853;product=Probable urease accessory protein UreD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2101651 2103042 . - . ID=CDS1;locus_tag=Rv1854c;product=Probable NADH dehydrogenase Ndh;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2103184 2104107 . - . ID=CDS1;locus_tag=Rv1855c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2104146 2104817 . - . ID=CDS1;locus_tag=Rv1856c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2104985 2105770 . + . ID=CDS1;locus_tag=Rv1857;product=Probable molybdate-binding lipoprotein ModA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2105773 2106567 . + . ID=CDS1;locus_tag=Rv1858;product=Probable molybdenum-transport integral membrane protein ABC transporter ModB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2106574 2107683 . + . ID=CDS1;locus_tag=Rv1859;product=Probable molybdenum-transport ATP-binding protein ABC transporter ModC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2107736 2108713 . + . ID=CDS1;locus_tag=Rv1860;product=Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2109165 2109470 . + . ID=CDS1;locus_tag=Rv1861;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2109544 2110584 . + . ID=CDS1;locus_tag=Rv1862;product=Probable alcohol dehydrogenase AdhA;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2110591 2111361 . - . ID=CDS1;locus_tag=Rv1863c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2111354 2112109 . - . ID=CDS1;locus_tag=Rv1864c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2112106 2112966 . - . ID=CDS1;locus_tag=Rv1865c;product=Probable short-chain type dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2113140 2115476 . + . ID=CDS1;locus_tag=Rv1866;product=Conserved protein;note=FunctionalCategory: lipid metabolism chr1 CDS 2115764 2117248 . + . ID=CDS1;locus_tag=Rv1867;product=putative acetyl-CoA acetyltransferase;Inference=profile:pathway enrichment method [PMID: 25098602]/note:FunctionalCategory: lipid metabolism;EC_number=2.3.1.9 chr1 CDS 2117347 2119446 . + . ID=CDS1;locus_tag=Rv1868;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2119460 2120695 . - . ID=CDS1;locus_tag=Rv1869c;product=Probable reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2120795 2121430 . - . ID=CDS1;locus_tag=Rv1870c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2121495 2121884 . - . ID=CDS1;locus_tag=Rv1871c;product=Conserved protein/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,3r5lA,4y9iA,3r5zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,3r5lA,4y9iA,3r5zA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,3r5lA,4y9iA,3r5zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,3r5lA,4y9iA,3r5zA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,3r5lA,4y9iA,3r5zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,3r5lA,4y9iA,3r5zA chr1 CDS 2121907 2123151 . - . ID=CDS1;locus_tag=Rv1872c;product=Possible L-lactate dehydrogenase (cytochrome) LldD2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2123174 2123611 . + . ID=CDS1;locus_tag=Rv1873;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2123684 2124370 . + . ID=CDS1;locus_tag=Rv1874;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2124381 2124824 . + . ID=CDS1;locus_tag=Rv1875;product=Conserved protein/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=1.3.-.-;Ontology_term=0070967/note:identified by similarity of predicted tertiary structure to PDB 1y30A,5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,5jabA,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0016627/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0070402/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0071949/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1y30A,5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,5jabA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 1y30A,1rfeA,5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,1rfeA,5jabA,Ontology_term=0042816/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0010181/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1y30A,5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,5jabA,Ontology_term=0009986/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1y30A,5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,5jabA,Ontology_term=0030170/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A chr1 CDS 2125340 2125819 . + . ID=CDS1;locus_tag=Rv1876;product=Probable bacterioferritin BfrA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2125904 2127967 . + . ID=CDS1;locus_tag=Rv1877;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2128022 2129374 . + . ID=CDS1;locus_tag=Rv1878;product=Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2129377 2130513 . + . ID=CDS1;locus_tag=Rv1879;product=putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2qpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qpxA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2qpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qpxA chr1 CDS 2130541 2131857 . - . ID=CDS1;locus_tag=Rv1880c;product=Probable cytochrome P450 140 Cyp140;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2131907 2132329 . - . ID=CDS1;locus_tag=Rv1881c;product=Possible conserved lipoprotein LppE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2132370 2133203 . - . ID=CDS1;locus_tag=Rv1882c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2133231 2133692 . - . ID=CDS1;locus_tag=Rv1883c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2133731 2134261 . - . ID=CDS1;locus_tag=Rv1884c;product=Probable resuscitation-promoting factor RpfC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2134273 2134872 . - . ID=CDS1;locus_tag=Rv1885c;product=Chorismate mutase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2134890 2135867 . - . ID=CDS1;locus_tag=Rv1886c;product=Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen);note=FunctionalCategory: lipid metabolism chr1 CDS 2136258 2137400 . + . ID=CDS1;locus_tag=Rv1887;product=Hypothetical protein;Experiment=DESCRIPTION:recombinant DNA expression via transposon insertion in vitro, phosphatase assays [PMID: 10781540]/note:FunctionalCategory: conserved hypotheticals/note:Type II transmembrane protein chr1 CDS 2137519 2138079 . - . ID=CDS1;locus_tag=Rv1888c;product=Possible transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2138444 2138617 . - . ID=CDS1;locus_tag=Rv1888A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Likely a non-functional fragment of a SAM-dependent methyltransferase;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA chr1 CDS 2138661 2139017 . - . ID=CDS1;locus_tag=Rv1889c;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA chr1 CDS 2139076 2139687 . - . ID=CDS1;locus_tag=Rv1890c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2139741 2140148 . + . ID=CDS1;locus_tag=Rv1891;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2140165 2140476 . + . ID=CDS1;locus_tag=Rv1892;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2140486 2140704 . + . ID=CDS1;locus_tag=Rv1893;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2140739 2141869 . - . ID=CDS1;locus_tag=Rv1894c;gene=nmo1;product=nitronate monooxygenase;Experiment=DESCRIPTION:protein purification, in vitro enzymatic activity and inhibition assays, gene expression[PMID: 23408846]/note:FunctionalCategory: conserved hypotheticals/note:predicted to be flavin-dependent/note:conserved histidine residue at position 199 is critical for enzyme function;EC_number=1.13.12.16 chr1 CDS 2142521 2143675 . + . ID=CDS1;locus_tag=Rv1895;product=Possible dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2143535 2144446 . - . ID=CDS1;locus_tag=Rv1896c;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA chr1 CDS 2144451 2144882 . - . ID=CDS1;locus_tag=Rv1897c;product=putative aminoacyl-tRNA forming ligase;note=FunctionalCategory: conserved hypotheticals;EC_number=6.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2hl1B,4rr6A,4rrfA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 2hl1B,4rr6A,4rrfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hl1B,4rr6A,4rrfA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2hl1B,4rr6A,4rrfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hl1B,4rr6A,4rrfA,Ontology_term=0004829/note:identified by similarity of predicted tertiary structure to PDB 2hl1B,4rr6A,4rrfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hl1B,4rr6A,4rrfA chr1 CDS 2144940 2145248 . + . ID=CDS1;locus_tag=Rv1898;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2145214 2146245 . - . ID=CDS1;locus_tag=Rv1899c;product=Possible lipoprotein LppD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2146245 2147633 . - . ID=CDS1;locus_tag=Rv1900c;product=Probable lignin peroxidase LipJ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2147662 2148954 . + . ID=CDS1;locus_tag=Rv1901;product=Probable CinA-like protein CinA;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2149006 2150274 . - . ID=CDS1;locus_tag=Rv1902c;product=Probable sialic acid-transport integral membrane protein NanT;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2150364 2150768 . + . ID=CDS1;locus_tag=Rv1903;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2150954 2151385 . + . ID=CDS1;locus_tag=Rv1904;product=putative transcriptional regulator;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1tilD,1vc1A,4qtpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tilD,1vc1A,4qtpA,Ontology_term=0045152/note:identified by similarity of predicted tertiary structure to PDB 1tilD,1vc1A,4qtpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tilD,1vc1A,4qtpA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1tilD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tilD chr1 CDS 2151433 2152395 . - . ID=CDS1;locus_tag=Rv1905c;product=Probable D-amino acid oxidase Aao;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2152425 2152895 . - . ID=CDS1;locus_tag=Rv1906c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2153235 2153882 . - . ID=CDS1;locus_tag=Rv1907c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2153889 2156111 . - . ID=CDS1;locus_tag=Rv1908c;product=Catalase-peroxidase-peroxynitritase T KatG;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2156149 2156592 . - . ID=CDS1;locus_tag=Rv1909c;product=Ferric uptake regulation protein FurA (fur);note=FunctionalCategory: regulatory proteins chr1 CDS 2156706 2157299 . - . ID=CDS1;locus_tag=Rv1910c;product=Probable exported protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2157382 2157987 . - . ID=CDS1;locus_tag=Rv1911c;product=Probable lipoprotein LppC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2158087 2159091 . - . ID=CDS1;locus_tag=Rv1912c;product=Possible oxidoreductase FadB5;note=FunctionalCategory: lipid metabolism chr1 CDS 2159191 2159943 . + . ID=CDS1;locus_tag=Rv1913;product=putative cyclic amide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1znbB,1jjeB,3q6vA,1m2xA,2fhxA,1ko3A,3q6xA,3faiA,1l9yA,1a7tA,3l6nA,1bvtA,4hl1A,5iqkA,2fu9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1jjeB,3q6vA,1m2xA,2fhxA,1ko3A,3q6xA,3faiA,1bvtA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jjeB,3q6vA,1m2xA,2fhxA,1ko3A,3q6xA,3faiA,1bvtA,4hl1A,2fu9A,Ontology_term=0008800/note:identified by similarity of predicted tertiary structure to PDB 1znbB,1jjeB,3q6vA,1m2xA,2fhxA,3q6xA,3faiA,1a7tA,3l6nA,1bvtA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1znbB,1jjeB,3q6vA,1m2xA,2fhxA,3q6xA,3faiA,1a7tA,3l6nA,1bvtA,4hl1A,2fu9A,Ontology_term=0017001/note:identified by similarity of predicted tertiary structure to PDB 1znbB,1jjeB,3q6vA,1m2xA,2fhxA,3q6xA,3faiA,1a7tA,3l6nA,1bvtA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1znbB,1jjeB,3q6vA,1m2xA,2fhxA,3q6xA,3faiA,1a7tA,3l6nA,1bvtA,4hl1A,2fu9A,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 1jjeB,3q6vA,1m2xA,3q6xA,3faiA,1bvtA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jjeB,3q6vA,1m2xA,3q6xA,3faiA,1bvtA,4hl1A,2fu9A,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1znbB,1jjeB,3q6vA,1m2xA,2fhxA,3q6xA,3faiA,1a7tA,3l6nA,1bvtA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1znbB,1jjeB,3q6vA,1m2xA,2fhxA,3q6xA,3faiA,1a7tA,3l6nA,1bvtA,4hl1A,2fu9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1jjeB,3q6vA,1m2xA,2fhxA,1ko3A,3q6xA,3faiA,3l6nA,1bvtA,4hl1A,5iqkA,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jjeB,3q6vA,1m2xA,2fhxA,1ko3A,3q6xA,3faiA,3l6nA,1bvtA,4hl1A,5iqkA,2fu9A,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 1m2xA,3q6xA,3faiA,1bvtA,4hl1A,2fu9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m2xA,3q6xA,3faiA,1bvtA,4hl1A,2fu9A chr1 CDS 2159921 2160328 . - . ID=CDS1;locus_tag=Rv1914c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2160463 2161566 . + . ID=CDS1;locus_tag=Rv1915;product=Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2161566 2162762 . + . ID=CDS1;locus_tag=Rv1916;product=Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2162932 2167311 . - . ID=CDS1;locus_tag=Rv1917c;gene=PPE34;product=Probable T-cell antigen/PPE family protein PPE34;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=DESCRIPTION: Protein expression and purification, flow cytometry, immunoblotting, immunoprecipitation assay [PMID: 20837474]/note:FunctionalCategory: PE/PPE/note:Interacts with TLR2 and triggers functional maturation of human dendritic cells and secretion of immunomodulatory cytokines [PMID: 20837474]/note:Facilitates a shift in the ensuing immunity toward the Th2 phenotype in vivo which could aid in immune evasion by mycobacteria [PMID: 20837474]/note:Associated with cell wall and partially exposed on cell surface [PMID: 20837474]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642] chr1 CDS 2167649 2170612 . - . ID=CDS1;locus_tag=Rv1918c;gene=PPE35;product=PPE family protein PPE35;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642]/note:upregulated in glycine/lysozyme treated M. tuberculosis [PMID: 23195184] chr1 CDS 2171061 2171525 . - . ID=CDS1;locus_tag=Rv1919c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2171623 2172486 . + . ID=CDS1;locus_tag=Rv1920;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2172524 2173795 . - . ID=CDS1;locus_tag=Rv1921c;product=Probable conserved lipoprotein LppF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2174067 2175182 . + . ID=CDS1;locus_tag=Rv1922;product=Putative aminopeptidase/putative beta-lactamase;note=FunctionalCategory: cell wall and cell processes, putative Peptidase. [PMID: 27324481];EC_number=3.4.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1ei5A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.5.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,2qmiA,3o3vA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4iviA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004177/note:identified by similarity of predicted tertiary structure to PDB 1ei5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,Ontology_term=0008800/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA,Ontology_term=0017001/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 2wzxA,2qz6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wzxA,2qz6A,Ontology_term=0030288/note:identified by similarity of predicted tertiary structure to PDB 2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zc7A,3wrtA,2wzxA,5evlA,5eviA,4netA,1zkjA,5e2gA,2qz6A,5e2hA,3o3vA,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 1ei5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1zkjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zkjA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 1ei5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3wrtA,1zkjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wrtA,1zkjA,Ontology_term=0033252/note:identified by similarity of predicted tertiary structure to PDB 2wzxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wzxA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1ei5A,2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,2zc7A,3wrtA,2wzxA,4netA,1zkjA,5e2gA,2qz6A,5e2hA chr1 CDS 2175173 2176513 . + . ID=CDS1;locus_tag=Rv1923;product=Probable lipase LipD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2176550 2176930 . - . ID=CDS1;locus_tag=Rv1924c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2177087 2178949 . + . ID=CDS1;locus_tag=Rv1925;product=Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2178957 2179436 . - . ID=CDS1;locus_tag=Rv1926c;product=Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2179673 2180446 . + . ID=CDS1;locus_tag=Rv1927;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2180450 2181217 . - . ID=CDS1;locus_tag=Rv1928c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2181262 2181906 . - . ID=CDS1;locus_tag=Rv1929c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2181918 2182442 . - . ID=CDS1;locus_tag=Rv1930c;product=putative hydro-lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.2.1.-/note:identified by similarity of predicted tertiary structure to PDB 3nooA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nooA chr1 CDS 2182460 2183239 . - . ID=CDS1;locus_tag=Rv1931c;product=AraC Family Transcriptional Regulator Protein;Experiment=DESCRIPTION: In Vivo gene knockout assay, protein cloning, mouse infection, protein complementation assays. [PMID: 15322050]/note:FunctionalCategory: regulatory proteins/note:regulates genes important for virulence [PMID: 15322050] chr1 CDS 2183372 2183869 . + . ID=CDS1;locus_tag=Rv1932;product=Probable thiol peroxidase Tpx;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2183866 2184957 . - . ID=CDS1;locus_tag=Rv1933c;product=Probable acyl-CoA dehydrogenase FadE18;note=FunctionalCategory: lipid metabolism chr1 CDS 2184959 2186188 . - . ID=CDS1;locus_tag=Rv1934c;product=Probable acyl-CoA dehydrogenase FadE17;note=FunctionalCategory: lipid metabolism chr1 CDS 2186203 2187159 . - . ID=CDS1;locus_tag=Rv1935c;product=Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 2187384 2188493 . + . ID=CDS1;locus_tag=Rv1936;product=Possible monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2188496 2191015 . + . ID=CDS1;locus_tag=Rv1937;product=Possible oxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2191027 2192097 . + . ID=CDS1;locus_tag=Rv1938;product=Probable epoxide hydrolase EphB (epoxide hydratase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2192094 2192609 . + . ID=CDS1;locus_tag=Rv1939;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2192606 2193667 . + . ID=CDS1;locus_tag=Rv1940;product=Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2193664 2194434 . + . ID=CDS1;locus_tag=Rv1941;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2194644 2194973 . - . ID=CDS1;locus_tag=Rv1942c;product=Possible toxin MazF5;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2194970 2195347 . - . ID=CDS1;locus_tag=Rv1943c;product=Possible antitoxin MazE5;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2195344 2195934 . - . ID=CDS1;locus_tag=Rv1944c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2195989 2197353 . + . ID=CDS1;locus_tag=Rv1945;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages, Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 14617159] chr1 CDS 2197508 2197960 . - . ID=CDS1;locus_tag=Rv1946c;product=Possible lipoprotein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2198024 2198425 . + . ID=CDS1;locus_tag=Rv1947;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2198714 2199064 . - . ID=CDS1;locus_tag=Rv1948c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2199075 2200034 . - . ID=CDS1;locus_tag=Rv1949c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2199998 2200189 . - . ID=CDS1;locus_tag=Rv1950c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2200190 2200486 . - . ID=CDS1;locus_tag=Rv1951c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2200726 2200941 . + . ID=CDS1;locus_tag=Rv1952;product=Possible antitoxin VapB14;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2200938 2201249 . + . ID=CDS1;locus_tag=Rv1953;product=Possible toxin VapC14;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2201223 2201744 . - . ID=CDS1;locus_tag=Rv1954c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2201277 2201579 . + . ID=CDS1;locus_tag=Rv1954A;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 2201719 2202096 . + . ID=CDS1;locus_tag=Rv1955;product=Possible toxin HigB;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2202138 2202587 . + . ID=CDS1;locus_tag=Rv1956;product=Possible antitoxin HigA;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2202584 2203129 . + . ID=CDS1;locus_tag=Rv1957;product=Probable SecB-like chaperone;Experiment=DESCRIPTION:in vivo gene replacement and recombinant gene expression in E.coli, pulse-chase analysis, western blot, in vivo pull down assays [PMID: 21536872]/note:FunctionalCategory: conserved hypotheticals/note:predicted to control the HigB-HigA TA system by stimulating HigA folding,Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2203018 2203632 . - . ID=CDS1;locus_tag=Rv1958c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2203681 2203977 . - . ID=CDS1;locus_tag=Rv1959c;product=Possible toxin ParE1;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2203974 2204225 . - . ID=CDS1;locus_tag=Rv1960c;product=Possible antitoxin ParD1;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2204212 2204706 . + . ID=CDS1;locus_tag=Rv1961;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2204866 2205273 . - . ID=CDS1;locus_tag=Rv1962c;product=Possible toxin VapC35. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2205277 2205549 . - . ID=CDS1;locus_tag=Rv1962A;product=Possible antitoxin VapB35;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2205582 2206802 . - . ID=CDS1;locus_tag=Rv1963c;product=Probable transcriptional repressor (probably TetR-family) Mce3R;note=FunctionalCategory: regulatory proteins chr1 CDS 2207700 2208497 . + . ID=CDS1;locus_tag=Rv1964;gene=yrbE3A;product=Conserved hypothetical integral membrane protein YrbE3A;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2208507 2209322 . + . ID=CDS1;locus_tag=Rv1965;gene=yrbE3B;product=Conserved hypothetical integral membrane protein YrbE3B;note=FunctionalCategory: virulence, detoxification, adaptation, induced and exported in vivo [PMID: 28442606] chr1 CDS 2209327 2210604 . + . ID=CDS1;locus_tag=Rv1966;product=Mce-family protein Mce3A;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2210601 2211629 . + . ID=CDS1;locus_tag=Rv1967;product=Mce-family protein Mce3B;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2211626 2212858 . + . ID=CDS1;locus_tag=Rv1968;product=Mce-family protein Mce3C;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2212855 2214126 . + . ID=CDS1;locus_tag=Rv1969;product=Mce-family protein Mce3D;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2214123 2215256 . + . ID=CDS1;locus_tag=Rv1970;product=Possible Mce-family lipoprotein LprM (Mce-family lipoprotein Mce3E);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2215257 2216570 . + . ID=CDS1;locus_tag=Rv1971;product=Mce-family protein Mce3F;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2216592 2217167 . + . ID=CDS1;locus_tag=Rv1972;product=Probable conserved Mce associated membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2217164 2217646 . + . ID=CDS1;locus_tag=Rv1973;product=Possible conserved Mce associated membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2217659 2218036 . + . ID=CDS1;locus_tag=Rv1974;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2218052 2218717 . + . ID=CDS1;locus_tag=Rv1975;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2218844 2219251 . - . ID=CDS1;locus_tag=Rv1976c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2219754 2220800 . + . ID=CDS1;locus_tag=Rv1977;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2220908 2221756 . + . ID=CDS1;locus_tag=Rv1978;product=Probable T-cell Antigen;Experiment=Interferon-gamma ELISPOT [PMID: 19467342]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 2221719 2223164 . - . ID=CDS1;locus_tag=Rv1979c;product=Possible conserved permease;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2223343 2224029 . - . ID=CDS1;locus_tag=Rv1980c;product=Immunogenic protein Mpt64 (antigen Mpt64/MPB64);note=FunctionalCategory: cell wall and cell processes, 5 peptides of this protein are presented to Th1-cells in a human leukocyte antigen (HLA)-promiscuous manner [PMID: 20134175], does not bind lysozyme [PMID: 27602573] chr1 CDS 2224220 2225188 . - . ID=CDS1;locus_tag=Rv1981c;product=Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein);note=FunctionalCategory: information pathways chr1 CDS 2225413 2225832 . - . ID=CDS1;locus_tag=Rv1982c;product=Possible toxin VapC36. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2225841 2226101 . - . ID=CDS1;locus_tag=Rv1982A;product=Possible antitoxin VapB36;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2226244 2227920 . + . ID=CDS1;locus_tag=Rv1983;gene=PE_PGRS35;product=PE-PGRS family protein PE_PGRS35;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 2227908 2228561 . - . ID=CDS1;locus_tag=Rv1984c;product=Probable cutinase precursor CFP21;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2228991 2229902 . - . ID=CDS1;locus_tag=Rv1985c;product=Probable transcriptional regulatory protein (probably LysR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 2230011 2230610 . + . ID=CDS1;locus_tag=Rv1986;product=EHR T-cell antigen;Experiment=DESCRIPTION:microbial RNA analysis, PBMC culture, ELISpot assays, intracellular cytokine staining assay, multiplex cytokine analysis [PMID: 21203487]/note:FunctionalCategory: cell wall and cell processes/note:produces a greater response to IL-2 than IFN-gamma [PMID: 21203487]/note:Rv1986 peptides are associated with a distinct pattern of cytokine production [PMID: 21203487]/note:induced during hypoxia [PMID: 21203487]/note:Annotated in TubercuList as Probable conserved integral membrane protein/note:Elicits a strong IL-2 recall response in Latent Mtb infection. [PMID: 27780773] chr1 CDS 2231026 2231454 . + . ID=CDS1;locus_tag=Rv1987;product=Possible chitinase;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2231680 2232219 . + . ID=CDS1;locus_tag=Rv1988;product=Probable 23S rRNA methyltransferase Erm(37);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2232739 2233299 . - . ID=CDS1;locus_tag=Rv1989c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2233296 2233637 . - . ID=CDS1;locus_tag=Rv1990c;product=Probable transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 2233881 2234216 . - . ID=CDS1;locus_tag=Rv1990A;product=Possible dehydrogenase (fragment);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2234305 2234649 . - . ID=CDS1;locus_tag=Rv1991c;product=Toxin MazF6;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2234643 2234891 . - . ID=CDS1;locus_tag=Rv1991A;product=Antitoxin MazE6;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2234991 2237306 . - . ID=CDS1;locus_tag=Rv1992c;product=Probable metal cation transporter P-type ATPase G CtpG;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2237303 2237575 . - . ID=CDS1;locus_tag=Rv1993c;product=putative chaperone;Experiment=DESCRIPTION:mutagenesis, metal quantification by mass spectrometry, microarray analysis [PMID: 21925112]/note:FunctionalCategory: conserved hypotheticals/note:enhances functionality of P1B-ATPases chr1 CDS 2237628 2237984 . - . ID=CDS1;locus_tag=Rv1994c;product=Metal sensor transcriptional regulator CmtR (ArsR-SmtB family);note=FunctionalCategory: regulatory proteins chr1 CDS 2238141 2238908 . + . ID=CDS1;locus_tag=Rv1995;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2239004 2239957 . + . ID=CDS1;locus_tag=Rv1996;product=latency-related universal stress protein/T-cell antigen;Experiment=DESCRIPTION:recombinant protein purification, enzyme-linked immunosorbent assay (ELISA) [PMID: 23676169],Experiment=DESCRIPTION:gene overexpression (of homolog) in M. bovis, antibiotic susceptibilitiy testing [PMID: 25664397]/inference:alignment:Clustal [PMID: 20541977]/note:FunctionalCategory: virulence, detoxification, adaptation/note:T-cell antigen [PMID:23676169]/note:overexpression increases susceptibility to isoniazid in M. bovis [PMID:25664397]/note:predicted to bind ATP and DosR-regulated [PMID:20541977]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 2240159 2242876 . + . ID=CDS1;locus_tag=Rv1997;product=Probable metal cation transporter P-type ATPase A CtpF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2242945 2243721 . - . ID=CDS1;locus_tag=Rv1998c;product=Putative oxo-acid lyase/putative phosphotransferase;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=4.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3b8iF/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.7.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3lyeA/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3eooA,3i4eA,3lg3A,1oqfA,1f8mA,1zlpB,3fa3B,1dquA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.11.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2duaA/inference:ab initio prediction:I-TASSER:5.1,EC_number=5.4.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1pymA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0032923/note:identified by similarity of predicted tertiary structure to PDB 1pymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pymA,Ontology_term=0005782/note:identified by similarity of predicted tertiary structure to PDB 1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dquA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0033978/note:identified by similarity of predicted tertiary structure to PDB 2duaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2duaA,Ontology_term=0008948/note:identified by similarity of predicted tertiary structure to PDB 3b8iF/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b8iF,Ontology_term=0035375/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0019752/note:identified by similarity of predicted tertiary structure to PDB 3i4eA,3lg3A,1f8mA,1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3i4eA,3lg3A,1f8mA,1dquA,Ontology_term=0052572/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0009062/note:identified by similarity of predicted tertiary structure to PDB 1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dquA,Ontology_term=0006099/note:identified by similarity of predicted tertiary structure to PDB 1f8mA,1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,1dquA,Ontology_term=0047776/note:identified by similarity of predicted tertiary structure to PDB 1zlpB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zlpB,Ontology_term=0009514/note:identified by similarity of predicted tertiary structure to PDB 1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dquA,Ontology_term=0006097/note:identified by similarity of predicted tertiary structure to PDB 1f8mA,1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,1dquA,Ontology_term=0030603/note:identified by similarity of predicted tertiary structure to PDB 1zlpB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zlpB,Ontology_term=0045733/note:identified by similarity of predicted tertiary structure to PDB 1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dquA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3b8iF,3i4eA,3lg3A,1oqfA,1f8mA,1zlpB,1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b8iF,3i4eA,3lg3A,1oqfA,1f8mA,1zlpB,1dquA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 1oqfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1oqfA,Ontology_term=0005777/note:identified by similarity of predicted tertiary structure to PDB 1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dquA,Ontology_term=0019629/note:identified by similarity of predicted tertiary structure to PDB 3eooA,1oqfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eooA,1oqfA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1zlpB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zlpB,Ontology_term=0016831/note:identified by similarity of predicted tertiary structure to PDB 3b8iF/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b8iF,Ontology_term=0071456/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3b8iF,1oqfA,1f8mA,1zlpB,3fa3B,1dquA,2duaA,1pymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b8iF,1oqfA,1f8mA,1zlpB,3fa3B,1dquA,2duaA,1pymA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1zlpB,3fa3B,2duaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zlpB,3fa3B,2duaA,Ontology_term=0046421/note:identified by similarity of predicted tertiary structure to PDB 3eooA,1oqfA,1f8mA,1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eooA,1oqfA,1f8mA,1dquA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3b8iF,3lyeA,3eooA,3i4eA,3lg3A,1oqfA,1f8mA,1zlpB,3fa3B,1dquA,2duaA,1pymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b8iF,3lyeA,3eooA,3i4eA,3lg3A,1oqfA,1f8mA,1zlpB,3fa3B,1dquA,2duaA,1pymA,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0001101/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3lyeA,3eooA,3i4eA,3lg3A,1oqfA,1f8mA,1zlpB,3fa3B,1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3lyeA,3eooA,3i4eA,3lg3A,1oqfA,1f8mA,1zlpB,3fa3B,1dquA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0010034/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0075141/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1pymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pymA,Ontology_term=0050188/note:identified by similarity of predicted tertiary structure to PDB 1pymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pymA,Ontology_term=0015976/note:identified by similarity of predicted tertiary structure to PDB 1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dquA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dquA,Ontology_term=0004451/note:identified by similarity of predicted tertiary structure to PDB 3i4eA,3lg3A,1f8mA,1dquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3i4eA,3lg3A,1f8mA,1dquA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0006102/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA,Ontology_term=0070542/note:identified by similarity of predicted tertiary structure to PDB 1f8mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f8mA chr1 CDS 2243816 2245138 . - . ID=CDS1;locus_tag=Rv1999c;product=Probable conserved integral membrane protein/putative amino acid transport protein;note=FunctionalCategory: cell wall and cell processes;Ontology_term=0015297/note:identified by similarity of predicted tertiary structure to PDB 3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l1lA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3gi9C,3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gi9C,3l1lA,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 3gi9C,3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gi9C,3l1lA,Ontology_term=0003333/note:identified by similarity of predicted tertiary structure to PDB 3gi9C,3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gi9C,3l1lA,Ontology_term=0006865/note:identified by similarity of predicted tertiary structure to PDB 3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l1lA,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3l1lA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3gi9C,3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gi9C,3l1lA,Ontology_term=0015171/note:identified by similarity of predicted tertiary structure to PDB 3gi9C,3l1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gi9C,3l1lA chr1 CDS 2245209 2246822 . + . ID=CDS1;locus_tag=Rv2000;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2246832 2247584 . + . ID=CDS1;locus_tag=Rv2001;product=putative thioester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2ownB,4zv3A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006633/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016790/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0004320/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016295/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016296/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB,Ontology_term=0016297/note:identified by similarity of predicted tertiary structure to PDB 2ownB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ownB chr1 CDS 2247660 2248442 . + . ID=CDS1;locus_tag=Rv2002;product=Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase);note=FunctionalCategory: lipid metabolism chr1 CDS 2248563 2249420 . - . ID=CDS1;locus_tag=Rv2003c;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=2.1.1.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2avnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2avnA,Ontology_term=0008757/note:identified by similarity of predicted tertiary structure to PDB 2avnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2avnA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2avnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2avnA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1vlmA,2avnA,2gs9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlmA,2avnA,2gs9A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 1vlmA,2avnA,2gs9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlmA,2avnA,2gs9A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 1vlmA,2avnA,2gs9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlmA,2avnA,2gs9A chr1 CDS 2249478 2250974 . - . ID=CDS1;locus_tag=Rv2004c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197], binds specifically to U397 macrophages and A549 epithelial cells to modulate immune responses [PMID: 16199660] chr1 CDS 2250996 2251883 . - . ID=CDS1;locus_tag=Rv2005c;product=putative universal stress protein family protein/T-cell antigen/putative metal ion transporter;Experiment=DESCRIPTION:recombinant protein purification, cell culture assays, enzyme-linked immunosorbent assay (ELISA) [PMID: 19440342]/inference:ab initio prediction:molecular docking [PMID: 26436944]/inference:alignment:Clustal [PMID: 20541977]/note:FunctionalCategory: virulence, detoxification, adaptation/note:T-cell antigen [PMID: 19440342]/note:molecular docking studies predict the Usp domain to bind amikacin and kanamycin [PMID: 26436944]/note:predicted to be DosR regulated [PMID: 20541977]/note:over expressed in amikacin and kanamycin resistant isolates [PMID: 27895634]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197]/note:identified by similarity of predicted tertiary structure to PDB 3g40A,3j1zP/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g40A,3j1zP chr1 CDS 2252002 2255985 . + . ID=CDS1;locus_tag=Rv2006;product=Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2256084 2256428 . - . ID=CDS1;locus_tag=Rv2007c;product=Ferredoxin FdxA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2256617 2257942 . - . ID=CDS1;locus_tag=Rv2008c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2258030 2258272 . + . ID=CDS1;locus_tag=Rv2009;product=Antitoxin VapB15;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2258273 2258671 . + . ID=CDS1;locus_tag=Rv2010;product=Toxin VapC15;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2258854 2259285 . - . ID=CDS1;locus_tag=Rv2011c;product=putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3bj6A,4fhtA,4b8xA,3bddA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bj6A,4fhtA,4b8xA,3bddA,Ontology_term=0044212/note:identified by similarity of predicted tertiary structure to PDB 4fhtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fhtA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3bj6A,4fhtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bj6A,4fhtA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 3bj6A,4fhtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bj6A,4fhtA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3bj6A,4fhtA,4b8xA,3bddA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bj6A,4fhtA,4b8xA,3bddA chr1 CDS 2259326 2259820 . + . ID=CDS1;locus_tag=Rv2012;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2260665 2261144 . + . ID=CDS1;locus_tag=Rv2013;product=Transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2261098 2261688 . + . ID=CDS1;locus_tag=Rv2014;product=Transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2261816 2263072 . - . ID=CDS1;locus_tag=Rv2015c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2263426 2264001 . + . ID=CDS1;locus_tag=Rv2016;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2263998 2265038 . + . ID=CDS1;locus_tag=Rv2017;product=Transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 2265280 2265999 . + . ID=CDS1;locus_tag=Rv2018;product=Probable antitoxin VapB/Antigen;Experiment=Protein purification and expression in E. coli, extraction of Total RNA, neutralization assay, in vivo rRNA cleavage assay, qRT-PCR, Protein purification and expression in M. smegmatis [PMID: 28066388],Experiment=ELISA [PMID: 23140854]/note:FunctionalCategory: conserved hypotheticals/note:inhibits ribonuclease activity of Rv2019, its toxin partner [PMID: 28066388]/note:recovers normal colony formation of E. coli [PMID: 28066388] chr1 CDS 2265989 2266405 . + . ID=CDS1;locus_tag=Rv2019;product=Probable toxin VapC | Probable ribonuclease;Experiment=Protein purification and expression in E. coli, extraction of Total RNA, neutralization assay, in vivo rRNA cleavage assay, qRT-PCR, Protein purification and expression in M. smegmatis [PMID: 28066388]/note:FunctionalCategory: conserved hypotheticals/note:exhibits ribonuclease activity that triggers growth defect in E. coli [PMID: 28066388]/note:exhibits rRNA cleavage activity [PMID: 28066388]/note:inhibits colony formation in E. coli [PMID: 28066388];EC_number=3.1.-.- chr1 CDS 2266421 2266720 . - . ID=CDS1;locus_tag=Rv2020c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2266805 2267110 . - . ID=CDS1;locus_tag=Rv2021c;product=Transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 2267119 2267724 . - . ID=CDS1;locus_tag=Rv2022c;product=Conserved protein;Experiment=DESCRIPTION:microbial RNA analysis, Enzyme-Linked ImmunoSpot (ELISPOT) assays [PMID: 23169589]/note:FunctionalCategory: conserved hypotheticals/note:Induces T-cell response, immunodominant protein (inferred by peptide binding prediction using ProPred [PMID: 23169589])/note:Predicted enduring hypoxic response (EHR) gene chr1 CDS 2267749 2268108 . - . ID=CDS1;locus_tag=Rv2023c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2268268 2268726 . - . ID=CDS1;locus_tag=Rv2023A;product=Hypothetical protein, pseudogene;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2268693 2270240 . - . ID=CDS1;locus_tag=Rv2024c;gene=mamB;product=Restriction enzyme/m-6-adenine DNA methyltransferase (Mycobacterial adenine methyltransferase B "MamB");Experiment=DESCRIPTION:plasmid cloning, targeted RE-degradation, single-molecule sequencing kinetics[PMID: 26704977]/note:FunctionalCategory: conserved hypotheticals/note:Type IIG Methyltransferase/note:m6A DNA methyltransferase/note:hemimethylates DNA at asymmetric motif site;EC_number=3.1.21.3,EC_number=2.1.1.72 chr1 CDS 2270750 2271748 . - . ID=CDS1;locus_tag=Rv2025c;product=Conserved membrane protein/putative cation transport protein;note=FunctionalCategory: cell wall and cell processes, produced in response to elevated cobalt or nickel levels [PMID: 17726022], regulated by KmtR repressor, binds kmtR [PMID: 17726022], regulated by cAMP [PMID: 24587015];Ontology_term=0008324/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0006812/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0098655/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0055085/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1 chr1 CDS 2271863 2272747 . - . ID=CDS1;locus_tag=Rv2026c;product=Universal stress protein family protein;Experiment=DESCRIPTION:MTB proteome microarray assay [PMID: 27698396]/note:FunctionalCategory: virulence, detoxification, adaptation/note:Probable interaction with host protein TRIM27 (which restricts survival of mycobacteria in macrophages) [PMID: 27698396] chr1 CDS 2272787 2274508 . - . ID=CDS1;locus_tag=Rv2027c;product=Two component sensor histidine kinase DosT;note=FunctionalCategory: regulatory proteins chr1 CDS 2274569 2275408 . - . ID=CDS1;locus_tag=Rv2028c;product=putative universal stress protein family protein/T-cell antigen/Putative transport protein;Experiment=DESCRIPTION:recombinant protein purification, enzyme-linked immunosorbent assay (ELISA) [PMID: 23676169]/inference:ab initio prediction:AutoDock Vina [PMID: 25964780]/note:FunctionalCategory: virulence, detoxification, adaptation/note:T-cell antigen [PMID:23676169]/note:In silico docking studies predict that activity of Rv2028c is ATP-dependent [PMID:25964780]/note:Protein-protein interactions (STRING) suggest that Rv2028c interacts with histidine kinase receptor (Rv2027c) [PMID:25964780]/note:Predicted to be DosR regulated [PMID:20541977]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197]/note:identified by similarity of predicted tertiary structure to PDB 3g40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g40A chr1 CDS 2275405 2276424 . - . ID=CDS1;locus_tag=Rv2029c;product=6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2276441 2278486 . - . ID=CDS1;locus_tag=Rv2030c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 2278498 2278932 . - . ID=CDS1;locus_tag=Rv2031c;product=Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2279129 2280124 . + . ID=CDS1;locus_tag=Rv2032;product=Conserved protein Acg | Latency antigen;Experiment=DESCRIPTION:Whole blood culture assays, Luminex multiplex immunoassay [PMID: 25025278]/note:FunctionalCategory: conserved hypotheticals/note:possible component of dormancy regulating DosR regulon [PMID: 28261197]/note:possible NADP(H) nitroreductase [PMID: 11854240]/note:macrophage-induced gene [PMID: 11854240] chr1 CDS 2280240 2281082 . - . ID=CDS1;locus_tag=Rv2033c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2281294 2281617 . + . ID=CDS1;locus_tag=Rv2034;product=ArsR repressor protein;note=FunctionalCategory: regulatory proteins chr1 CDS 2281614 2282102 . + . ID=CDS1;locus_tag=Rv2035;product=Putative Type II toxin;Experiment=DESCRIPTION:protein purification and expression of M. smegmatis orthologs in E. coli, crystallization and structure determination [PMID: 27917833]/inference:profile:Structure Analysis and VErification Server (SAVES) [PMID: 27917833]/note:FunctionalCategory: conserved hypotheticals/note:part of a toxin-antitoxin system with Rv2034 [PMID: 27917833]/note:involved in hypoxic response [PMID: 18231589] chr1 CDS 2282099 2282740 . + . ID=CDS1;locus_tag=Rv2036;product=putative thiol-dependent DinB-like metalloenzyme;note=FunctionalCategory: conserved hypotheticals, identified by similarity of predicted tertiary structure to PDB:2nsgA,2nsfA;Inference=ab initio prediction:I-TASSER:5.1/note:Shares the four-helix up-down-down-up bundle, salt-bridge domain-linking residues, metal-coordinating histidine triad, and predicted metal-binding site characteristic of DinB family metalloenzymes/note:Has the thiol-interacting Trp and Arg residues of the catalytic center conserved/note:potential mycothiol-dependent S-transferase (EC 2.-.-.-);Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2nsgA,2nsfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nsgA,2nsfA chr1 CDS 2282747 2283721 . - . ID=CDS1;locus_tag=Rv2037c;product=Conserved transmembrane protein/Putative lipase;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB 5fquA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5fquA chr1 CDS 2283723 2284796 . - . ID=CDS1;locus_tag=Rv2038c;product=Probable sugar-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2284799 2285641 . - . ID=CDS1;locus_tag=Rv2039c;product=Probable sugar-transport integral membrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2285628 2286530 . - . ID=CDS1;locus_tag=Rv2040c;product=Probable sugar-transport integral membrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2286527 2287846 . - . ID=CDS1;locus_tag=Rv2041c;product=Probable sugar-binding lipoprotein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2287884 2288681 . - . ID=CDS1;locus_tag=Rv2042c;product=Conserved protein/Putative intramolecular lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=5.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB 3rgaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rgaA chr1 CDS 2288681 2289241 . - . ID=CDS1;locus_tag=Rv2043c;product=Pyrazinamidase/nicotinamidase PncA (PZase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2289282 2289599 . - . ID=CDS1;locus_tag=Rv2044c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2289685 2291220 . - . ID=CDS1;locus_tag=Rv2045c;product=Carboxylesterase LipT;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2291269 2291925 . + . ID=CDS1;locus_tag=Rv2046;product=Probable lipoprotein LppI;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2291962 2294526 . - . ID=CDS1;locus_tag=Rv2047c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2294531 2306986 . - . ID=CDS1;locus_tag=Rv2048c;product=Polyketide synthase Pks12;note=FunctionalCategory: lipid metabolism chr1 CDS 2307293 2307517 . - . ID=CDS1;locus_tag=Rv2049c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2307821 2308156 . + . ID=CDS1;locus_tag=Rv2050;gene=rbpA;product=RNA polymerase-binding protein A (RbpA);Experiment=DESCRIPTION: in vivo recombinant DNA expression, NMR, yeast two-hybrid assay, interaction assay [PMID: 23548911],Experiment=DESCRIPTION: in vitro transcription, electrophoretic mobility shift assay, protein purification, western blotting, FeBABE conjugation [PMID: 22570422],Experiment=DESCRIPTION: protein purification and expression, , In vitro aborted transcription assay, stopped-flow fluorescence assay [PMID: 27342278]/note:FunctionalCategory: conserved hypotheticals/note:stabilizes σA-containing RNA polymerase holoenzyme [PMID: 22570422]/note:Binds near the upstream edge of -10 element and likely facilitates DNA bending and impedes transcription bubble collapse. [PMID: 28067618]/note:Binding affinity specific to specific to σA and σB [PMID: 27342278]/note:Binds cooperatively with carD to stabilize open-complex formation more quickly than either factor bound alone [PMID: 27342278] chr1 CDS 2308131 2308976 . - . ID=CDS1;locus_tag=Rv2051c;product=Polyprenol-monophosphomannose synthase Ppm1;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2310913 2312517 . - . ID=CDS1;locus_tag=Rv2052c;product=Conserved protein/putative endodeoxyribonuclease;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.21.-;Ontology_term=0006259/note:identified by similarity of predicted tertiary structure to PDB 3ighX,3ighX1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ighX,3ighX1,Ontology_term=0016888/note:identified by similarity of predicted tertiary structure to PDB 3ighX,3ighX1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ighX,3ighX1,Ontology_term=0016810/note:identified by similarity of predicted tertiary structure to PDB 3ighX,3ighX1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ighX,3ighX1 chr1 CDS 2312522 2313049 . - . ID=CDS1;locus_tag=Rv2053c;product=Probable transmembrane protein FxsA;note=FunctionalCategory: cell wall and cell processes, induced in the presence of THZ (Thioridazine) [PMID: 20386700] chr1 CDS 2313125 2313838 . + . ID=CDS1;locus_tag=Rv2054;product=Conserved protein/putative peptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.14.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2ecfA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008236/note:identified by similarity of predicted tertiary structure to PDB 2ecfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ecfA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 2ecfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ecfA chr1 CDS 2314087 2314353 . - . ID=CDS1;locus_tag=Rv2055c;product=30S ribosomal protein S18 RpsR2;note=FunctionalCategory: information pathways chr1 CDS 2314354 2314659 . - . ID=CDS1;locus_tag=Rv2056c;product=30S ribosomal protein S14 RpsN2;note=FunctionalCategory: information pathways chr1 CDS 2314661 2314825 . - . ID=CDS1;locus_tag=Rv2057c;product=50S ribosomal protein L33 RpmG1;note=FunctionalCategory: information pathways chr1 CDS 2314825 2315061 . - . ID=CDS1;locus_tag=Rv2058c;product=50S ribosomal protein L28 RpmB2;note=FunctionalCategory: information pathways chr1 CDS 2315174 2316709 . + . ID=CDS1;locus_tag=Rv2059;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Product observed to belonged to a superfamily of proteins functioning as initial receptors as ABC transport of Zn2+ and Mn2+ in many eubacterial species. [PMID: 27630619] chr1 CDS 2316279 2316680 . + . ID=CDS1;locus_tag=Rv2060;product=Possible conserved integral membrane protein/putative transport protein;note=FunctionalCategory: cell wall and cell processes, upregulated in the absence of ESX-3 [PMID: 24155985], upregulated in presence of zinc [PMID: 25481572];Ontology_term=0005215/note:identified by similarity of predicted tertiary structure to PDB 2nq2A1,2nq2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nq2A1,2nq2A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 2nq2A1,2nq2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nq2A1,2nq2A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2nq2A1,2nq2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nq2A1,2nq2A,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 2nq2A1,2nq2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nq2A1,2nq2A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2nq2A1,2nq2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2nq2A1,2nq2A chr1 CDS 2316681 2317085 . - . ID=CDS1;locus_tag=Rv2061c;product=probable serine hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals,Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.1.-.- chr1 CDS 2317169 2320753 . - . ID=CDS1;locus_tag=Rv2062c;product=Cobalamin biosynthesis protein CobN;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2320831 2321064 . + . ID=CDS1;locus_tag=Rv2063;product=Antitoxin MazE7;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2321057 2321467 . + . ID=CDS1;locus_tag=Rv2063A;product=Possible toxin MazF7;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2321451 2322542 . + . ID=CDS1;locus_tag=Rv2064;product=Precorrin-3B synthase CobG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2322552 2323178 . + . ID=CDS1;locus_tag=Rv2065;product=Precorrin-8X methylmutase CobH (aka precorrin isomerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2323175 2324701 . + . ID=CDS1;locus_tag=Rv2066;product=Probable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2324647 2325870 . - . ID=CDS1;locus_tag=Rv2067c;product=Conserved protein/Putative one-carbon transferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB 5dooA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5dooA chr1 CDS 2325886 2326809 . - . ID=CDS1;locus_tag=Rv2068c;product=Class a beta-lactamase BlaC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2326944 2327501 . + . ID=CDS1;locus_tag=Rv2069;product=RNA polymerase sigma factor, ECF subfamily, SigC;note=FunctionalCategory: information pathways chr1 CDS 2327491 2328225 . - . ID=CDS1;locus_tag=Rv2070c;product=Precorrin-6X reductase CobK;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2328222 2328977 . - . ID=CDS1;locus_tag=Rv2071c;product=Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2328974 2330146 . - . ID=CDS1;locus_tag=Rv2072c;product=Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2330214 2330963 . - . ID=CDS1;locus_tag=Rv2073c;product=Probable short-chain dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2330993 2331406 . + . ID=CDS1;locus_tag=Rv2074;product=Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=F420 purification, in vitro recombinant protein expression and purification, enzyme activity assays and reaction product analysis [PMID: 27364382],Experiment=protein crystallization and structural determination, substrate docking and molecular dynamics simulations[PMID: 27364382]/inference:similar to AA sequence: BLAST, Enzyme Function Initiative Enzyme Similarity Tool [PMID: 27364382] chr1 CDS 2331416 2332879 . - . ID=CDS1;locus_tag=Rv2075c;product=Possible hypothetical exported or envelope protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2333037 2333288 . - . ID=CDS1;locus_tag=Rv2076c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2333323 2334294 . - . ID=CDS1;locus_tag=Rv2077c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2334295 2334594 . - . ID=CDS1;locus_tag=Rv2077A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2335059 2335373 . + . ID=CDS1;locus_tag=Rv2078;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2335355 2337325 . + . ID=CDS1;locus_tag=Rv2079;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2337306 2337869 . + . ID=CDS1;locus_tag=Rv2080;product=Lipoprotein LppJ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2338065 2338505 . - . ID=CDS1;locus_tag=Rv2081c;product=Conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2338709 2340874 . + . ID=CDS1;locus_tag=Rv2082;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, structurally similar to coatamer proteins in mouse that mediate biosynthetic transport from the endoplasmic reticulum, possibly involved in host-pathogen interation, identified by similarity of predicted tertiary structure to PDB 5a1uG;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a1uG chr1 CDS 2340871 2341815 . + . ID=CDS1;locus_tag=Rv2083;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2341808 2342944 . + . ID=CDS1;locus_tag=Rv2084;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 2343027 2343332 . + . ID=CDS1;locus_tag=Rv2085;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2343311 2343916 . + . ID=CDS1;locus_tag=Rv2086;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2343994 2344224 . + . ID=CDS1;locus_tag=Rv2087;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2344411 2346180 . + . ID=CDS1;locus_tag=Rv2088;product=Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J);note=FunctionalCategory: regulatory proteins chr1 CDS 2346197 2347324 . - . ID=CDS1;locus_tag=Rv2089c;product=Dipeptidase PepE;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2347373 2348554 . + . ID=CDS1;locus_tag=Rv2090;product=Probable 5'-3' exonuclease;note=FunctionalCategory: information pathways chr1 CDS 2348558 2349292 . - . ID=CDS1;locus_tag=Rv2091c;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2349334 2352054 . - . ID=CDS1;locus_tag=Rv2092c;product=ATP-dependent DNA helicase HelY;note=FunctionalCategory: information pathways chr1 CDS 2352103 2353029 . - . ID=CDS1;locus_tag=Rv2093c;product=Sec-independent protein translocase transmembrane protein TatC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2353046 2353297 . - . ID=CDS1;locus_tag=Rv2094c;product=Sec-independent protein translocase membrane-bound protein TatA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2353365 2354315 . - . ID=CDS1;locus_tag=Rv2095c;product=Proteasome accessory factor C PafC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2354312 2355310 . - . ID=CDS1;locus_tag=Rv2096c;product=Proteasome accessory factor B PafB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2355319 2356677 . - . ID=CDS1;locus_tag=Rv2097c;product=Proteasome accessory factor a PafA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2356729 2358033 . - . ID=CDS1;locus_tag=Rv2098c;gene=PE_PGRS36;product=PE-PGRS family protein PE_PGRS36;note=FunctionalCategory: PE/PPE chr1 CDS 2358033 2358206 . - . ID=CDS1;locus_tag=Rv2099c;gene=PE21;product=PE family protein PE21;note=FunctionalCategory: PE/PPE, The NCBI gene record for this gene has been discontinued [PMID: 22618876] chr1 CDS 2358389 2360041 . + . ID=CDS1;locus_tag=Rv2100;product=Conserved hypothetical protein;Experiment=DESCRIPTION:ChIP-seq [PMID: 22528497]/note:FunctionalCategory: insertion seqs and phages/note:Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 22528497] chr1 CDS 2360240 2363281 . + . ID=CDS1;locus_tag=Rv2101;product=Probable helicase HelZ;note=FunctionalCategory: information pathways chr1 CDS 2363391 2364107 . + . ID=CDS1;locus_tag=Rv2102;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2364086 2364520 . - . ID=CDS1;locus_tag=Rv2103c;product=Possible toxin VapC37. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2364527 2364781 . - . ID=CDS1;locus_tag=Rv2104c;product=Possible antitoxin VapB37;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2365465 2365791 . + . ID=CDS1;locus_tag=Rv2105;product=Putative transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2365740 2366726 . + . ID=CDS1;locus_tag=Rv2106;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2367359 2367655 . + . ID=CDS1;locus_tag=Rv2107;gene=PE22;product=PE family protein PE22;note=FunctionalCategory: PE/PPE, Upregulated under oxygen depletion [PMID: 26001906], located upstream of PPE36 (Rv2108) gene and is required for expression of PPE36 in E.coli [PMID: 28119467] chr1 CDS 2367711 2368442 . + . ID=CDS1;locus_tag=Rv2108;gene=p27;product=Probable IgA antigen/PPE family protein PPE36;Experiment=DESCRIPTION:Western blot, immunoelectron microscopic [PMID: 15958258],Experiment=DESCRIPTION:Protein expression and purification, mouse immunization, ELISA [PMID: 18289677],Experiment=DESCRIPTION:ELISA [PMID: 23140854]/note:FunctionalCategory: PE/PPE/note:Located in the cell membrane [PMID: 15958258]/note:Induces TH1-like immune response [PMID: 18289677]/note:Shows presence of IgA antibody response but absence of IgG antibody response [PMID: 23140854]/note:Essential for heme utilization by M. tuberculosis in vitro [PMID: 28119467] chr1 CDS 2368983 2369729 . - . ID=CDS1;locus_tag=Rv2109c;product=Proteasome alpha subunit PrcA/ assembles with beta subunit PrcB.;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2369726 2370601 . - . ID=CDS1;locus_tag=Rv2110c;product=Proteasome beta subunit PrcB/ assembles with alpha subunit PrcA.;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2370598 2370792 . - . ID=CDS1;locus_tag=Rv2111c;product=Prokaryotic ubiquitin-like protein Pup;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2370905 2372569 . - . ID=CDS1;locus_tag=Rv2112c;product=Deamidase of pup Dop;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2372630 2373823 . + . ID=CDS1;locus_tag=Rv2113;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2373834 2374457 . + . ID=CDS1;locus_tag=Rv2114;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2374461 2376290 . - . ID=CDS1;locus_tag=Rv2115c;product=Mycobacterial proteasome ATPase Mpa;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2376571 2377140 . + . ID=CDS1;locus_tag=Rv2116;product=Conserved lipoprotein LppK;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2377148 2377441 . + . ID=CDS1;locus_tag=Rv2117;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2377470 2378312 . - . ID=CDS1;locus_tag=Rv2118c;product=RNA methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2378386 2379222 . + . ID=CDS1;locus_tag=Rv2119;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2379245 2379727 . - . ID=CDS1;locus_tag=Rv2120c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2379806 2380660 . - . ID=CDS1;locus_tag=Rv2121c;product=ATP phosphoribosyltransferase HisG;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2380663 2380944 . - . ID=CDS1;locus_tag=Rv2122c;product=Phosphoribosyl-AMP pyrophosphatase HisE;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2381071 2382492 . + . ID=CDS1;locus_tag=Rv2123;gene=PPE37;product=PPE family protein PPE37;note=FunctionalCategory: PE/PPE, induces low tumor necrosis factor alpha and interleukin 6 production in murine macrophages [PMID: 21233299] chr1 CDS 2382489 2386067 . - . ID=CDS1;locus_tag=Rv2124c;product=5-methyltetrahydrofolate--homocysteine methyltransferase MetH (methionine synthase, vitamin-B12 dependent isozyme) (ms);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2386293 2387171 . + . ID=CDS1;locus_tag=Rv2125;product=Conserved hypothetical protein;Experiment=DESCRIPTION:in vivo nitric oxide (NO) exposure, microarray data analysis [PMID: 21734908]/note:FunctionalCategory: conserved hypotheticals/note:induced by NO chr1 CDS 2387202 2387972 . - . ID=CDS1;locus_tag=Rv2126c;gene=PE_PGRS37;product=PE-PGRS family protein PE_PGRS37;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642]/note:Upregulated after capreomycin exposure [PMID: 21678479] chr1 CDS 2388616 2390085 . + . ID=CDS1;locus_tag=Rv2127;product=L-asparagine permease AnsP1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2390085 2390288 . + . ID=CDS1;locus_tag=Rv2128;product=Conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2390308 2391189 . - . ID=CDS1;locus_tag=Rv2129c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2391215 2392459 . - . ID=CDS1;locus_tag=Rv2130c;product=Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2392517 2393320 . - . ID=CDS1;locus_tag=Rv2131c;product=Monophosphatase CysQ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2393411 2393641 . + . ID=CDS1;locus_tag=Rv2132;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2393851 2394639 . - . ID=CDS1;locus_tag=Rv2133c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2394650 2395237 . - . ID=CDS1;locus_tag=Rv2134c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2395301 2396011 . - . ID=CDS1;locus_tag=Rv2135c;product=acid phosphatase;Experiment=DESCRIPTION:cloning, expression, acid phosphatase assay [PMID: 24330471]/inference:alignment:ClustalX2 [PMID: 24330471]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.3.2,EC_number=5.4.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1riiA,2a6pA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0061621/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,1fztA,Ontology_term=0016868/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA,Ontology_term=0043209/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1yjxA,Ontology_term=0004082/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0019901/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0034774/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,1fztA,Ontology_term=0046538/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1qhfA,1yjxA,2hhjA,1e58A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1qhfA,1yjxA,2hhjA,1e58A,1fztA,Ontology_term=0006110/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0007585/note:identified by similarity of predicted tertiary structure to PDB 2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hhjA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA,Ontology_term=0043312/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0045730/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=1904813/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1qhfA,1yjxA,1e58A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,1yjxA,1e58A,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1fztA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1qhfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,Ontology_term=0004619/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA,Ontology_term=0005741/note:identified by similarity of predicted tertiary structure to PDB 1qhfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,Ontology_term=0006096/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA,Ontology_term=0006094/note:identified by similarity of predicted tertiary structure to PDB 1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,4embA,1qhfA,1yjxA,2hhjA,1e58A,3gp5A,1fztA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1yjxA,2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA,2hhjA,Ontology_term=0005758/note:identified by similarity of predicted tertiary structure to PDB 1qhfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhfA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1riiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,Ontology_term=0043456/note:identified by similarity of predicted tertiary structure to PDB 1riiA,1qhfA,1yjxA,2hhjA,1e58A,1fztA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1riiA,1qhfA,1yjxA,2hhjA,1e58A,1fztA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 2hhjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hhjA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1yjxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yjxA chr1 CDS 2396008 2396838 . - . ID=CDS1;locus_tag=Rv2136c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, not involved in acid resistance in TB [PMID: 21778115] chr1 CDS 2396902 2397315 . - . ID=CDS1;locus_tag=Rv2137c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2397330 2398406 . + . ID=CDS1;locus_tag=Rv2138;product=Probable conserved lipoprotein LppL;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2398720 2399793 . + . ID=CDS1;locus_tag=Rv2139;product=Probable dihydroorotate dehydrogenase PyrD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2399798 2400328 . - . ID=CDS1;locus_tag=Rv2140c;product=Phosphatidylethanolamine-binding protein TB18.6;Experiment=DESCRIPTION:Isothermal titration calorimetry, crystal structuralization, structural homology [PMID: 23907008],Experiment=DESCRIPTION:protein isolation and precipitation, 2D-gel electrophoresis, in-gel digestion and mass spectrometry [PMID: 27895634]/inference:ab initio prediction:InterProScan [PMID: 27895634]/inference:ab initio prediction:Molecular docking [PMID: 27895634]/inference:protein motif:InterProScan, alignment:CLUSTALW, BLASTP, ab initio prediction:VMD software, PatchDock, FireDock [PMID: 26238929]/note:Contains locostatin binding site/note:FunctionalCategory: conserved hypotheticals/note:Ofloxacin is predicted to interact with the USP domain of this protein (Molecular docking analysis) [PMID: 26238929]/note:over expressed in amikacin and kanamycin resistant isolates and the conserved domain of this gene is predicted to interact with these drugs [PMID: 27895634] chr1 CDS 2400376 2401722 . - . ID=CDS1;locus_tag=Rv2141c;product=Conserved protein/putative linear amide hydrolase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2f8hA,1r43A,4ewtA,3tx8A,4wjbA,3pfoA,3ic1A,1ysjA,1vgyA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0003837/note:identified by similarity of predicted tertiary structure to PDB 1r43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1r43A,Ontology_term=0008237/note:identified by similarity of predicted tertiary structure to PDB 3tx8A,3ic1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tx8A,3ic1A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2f8hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f8hA,Ontology_term=0008777/note:identified by similarity of predicted tertiary structure to PDB 2f8hA,3pfoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f8hA,3pfoA,Ontology_term=0006526/note:identified by similarity of predicted tertiary structure to PDB 2f8hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f8hA,Ontology_term=0019877/note:identified by similarity of predicted tertiary structure to PDB 3tx8A,3ic1A,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tx8A,3ic1A,1vgyA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3tx8A,3ic1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tx8A,3ic1A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1r43A,4ewtA,3tx8A,4wjbA,3pfoA,3ic1A,1ysjA,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1r43A,4ewtA,3tx8A,4wjbA,3pfoA,3ic1A,1ysjA,1vgyA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2f8hA,1r43A,4ewtA,3tx8A,4wjbA,3pfoA,3ic1A,1ysjA,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f8hA,1r43A,4ewtA,3tx8A,4wjbA,3pfoA,3ic1A,1ysjA,1vgyA,Ontology_term=0009014/note:identified by similarity of predicted tertiary structure to PDB 3tx8A,3ic1A,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tx8A,3ic1A,1vgyA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2f8hA,1r43A,4ewtA,3tx8A,4wjbA,3pfoA,3ic1A,1ysjA,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f8hA,1r43A,4ewtA,3tx8A,4wjbA,3pfoA,3ic1A,1ysjA,1vgyA,Ontology_term=0008652/note:identified by similarity of predicted tertiary structure to PDB 3tx8A,3ic1A,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tx8A,3ic1A,1vgyA,Ontology_term=0016813/note:identified by similarity of predicted tertiary structure to PDB 1r43A,4wjbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1r43A,4wjbA,Ontology_term=0009089/note:identified by similarity of predicted tertiary structure to PDB 3tx8A,3ic1A,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tx8A,3ic1A,1vgyA,Ontology_term=0009085/note:identified by similarity of predicted tertiary structure to PDB 3tx8A,3ic1A,1vgyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tx8A,3ic1A,1vgyA chr1 CDS 2402193 2402510 . - . ID=CDS1;locus_tag=Rv2142c;product=Possible toxin ParE2;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2402507 2402722 . - . ID=CDS1;locus_tag=Rv2142A;product=Possible antitoxin ParD2;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2402977 2404035 . + . ID=CDS1;locus_tag=Rv2143;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, possible phosphoribosyl transferase [PMID: 27973588] chr1 CDS 2404165 2404521 . - . ID=CDS1;locus_tag=Rv2144c;product=Probable transmembrane protein;note=FunctionalCategory: cell wall and cell processes, induced and exported in vivo [PMID: 28442606] chr1 CDS 2404616 2405398 . - . ID=CDS1;locus_tag=Rv2145c;product=Diviva family protein Wag31;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2405666 2405956 . - . ID=CDS1;locus_tag=Rv2146c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2406118 2406843 . - . ID=CDS1;locus_tag=Rv2147c;gene=SepF;product=conserved protein;Experiment=DESCRIPTION:gene expression and purification of gene product, gene knockout studies [PMID: 25971440]/note:essential for cell division [PMID: 25971440]/note:growth factor/prevents unnatural cell elongation/interacts with FtsZ/interacts with MurG [PMID: 25971440]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 2406840 2407616 . - . ID=CDS1;locus_tag=Rv2148c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2407622 2408374 . - . ID=CDS1;locus_tag=Rv2149c;gene=yfiH;product=Conserved protein YfiH;Inference=similar to AA sequence:Cluster of Orthologous groups COG:1496 [PMID: 22485162]/note:FunctionalCategory: conserved hypotheticals/note:putative function in cell wall biosynthesis/cell division [PMID: 22485162] chr1 CDS 2408385 2409524 . - . ID=CDS1;locus_tag=Rv2150c;product=Cell division protein FtsZ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2409697 2410641 . - . ID=CDS1;locus_tag=Rv2151c;product=Possible cell division protein FtsQ;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2410638 2412122 . - . ID=CDS1;locus_tag=Rv2152c;product=Probable UDP-N-acetylmuramate-alanine ligase MurC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2412119 2413351 . - . ID=CDS1;locus_tag=Rv2153c;product=Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2413348 2414922 . - . ID=CDS1;locus_tag=Rv2154c;product=FtsW-like protein FtsW;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2414934 2416394 . - . ID=CDS1;locus_tag=Rv2155c;product=Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2416396 2417475 . - . ID=CDS1;locus_tag=Rv2156c;product=Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2417472 2419004 . - . ID=CDS1;locus_tag=Rv2157c;product=Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2419001 2420554 . - . ID=CDS1;locus_tag=Rv2158c;product=Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2420631 2421665 . - . ID=CDS1;locus_tag=Rv2159c;product=Alkylhydroperoxidase;Experiment=DESCRIPTION:Gene expression and purification, site directed mutagenesis of active and catalytic sites, pull down assay, enzyme activity assay using HPLC, DTT-dependent activity assay [PMID: 27818650],Experiment=DESCRIPTION:Electroelution, far-Western Blot, Mass Spectrometry [PMID: 26546727]/inference:ab initio prediction:Z-Dock and ClusPro [PMID: 26546727]/note:FunctionalCategory: conserved hypotheticals/note:Interacts with Pknl [PMID: 26546727]/note:Member of carboxymuconolactone decarboxylase family with peroxidase activity. [PMID: 27818650]/note:Interaction with PknI rapidly increased Rv2159c's peroxidase activity but there is not phosphorylation involved in this interaction [PMID: 27818650]/note:Knockdown of this gene leads to total susceptibility to peroxides [PMID: 27818650] chr1 CDS 2421643 2422278 . - . ID=CDS1;locus_tag=Rv2160A;product=putative transcription factor;note=FunctionalCategory: regulatory proteins, Homologous to M. bovis BCG_2177c. [PMID: 28321208];Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA chr1 CDS 2421662 2422003 . - . ID=CDS1;locus_tag=Rv2160c;product=putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2hyjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hyjA chr1 CDS 2422271 2423137 . - . ID=CDS1;locus_tag=Rv2161c;product=Conserved protein/putative monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration, putatively involved in lincomycin-synthesizing pathway [PMID: 12456788];EC_number=1.14.14.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1nqkA,3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.5.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1z69A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.14.13.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3sdoA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004497/note:identified by similarity of predicted tertiary structure to PDB 1nqkA,3fgcD,3fgcA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,3fgcD,3fgcA,3sdoA,Ontology_term=0006730/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0046306/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0047646/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0019386/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0015948/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0008218/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1nqkA,3fgcD,3fgcA,1z69A,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,3fgcD,3fgcA,1z69A,3sdoA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0016705/note:identified by similarity of predicted tertiary structure to PDB 1rhcA,1nqkA,3fgcD,3fgcA,1z69A,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rhcA,1nqkA,3fgcD,3fgcA,1z69A,3sdoA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0008726/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1rhcA,1nqkA,3fgcD,3fgcA,1z69A,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rhcA,1nqkA,3fgcD,3fgcA,1z69A,3sdoA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0018537/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A chr1 CDS 2423240 2424838 . - . ID=CDS1;locus_tag=Rv2162c;gene=PE_PGRS38;product=PE-PGRS family protein PE_PGRS38;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938]/note:FunctionalCategory: PE/PPE/note:Located in the cell membrane [PMID: 21261938]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642] chr1 CDS 2425048 2427087 . - . ID=CDS1;locus_tag=Rv2163c;product=Probable penicillin-binding membrane protein PbpB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2427084 2428238 . - . ID=CDS1;locus_tag=Rv2164c;product=Probable conserved proline rich membrane protein;note=FunctionalCategory: cell wall and cell processes, Up regulated in otsB2 mutant strain (trehalose-6-phosphate phosphatase silenced strain) [PMID: 27936238] chr1 CDS 2428235 2429425 . - . ID=CDS1;locus_tag=Rv2165c;product=conserved protein;Experiment=DESCRIPTION:high density mutagenesis [PMID: 12657046]/note:FunctionalCategory: conserved hypotheticals/note:confirmed as essential/note:possible S-adenosyl-methyltransferase MraW [PMID: 26983646]/note:Up regulated in otsB2 mutant strain (trehalose-6-phosphate phosphatase silenced strain) [PMID: 27936238] chr1 CDS 2429427 2429858 . - . ID=CDS1;locus_tag=Rv2166c;product=Conserved protein/putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1n0eB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n0eB,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 1n0eB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n0eB,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1n0eB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n0eB,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1n0eB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n0eB,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1n0eB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n0eB,Ontology_term=0009295/note:identified by similarity of predicted tertiary structure to PDB 1n0eB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1n0eB chr1 CDS 2430159 2431145 . - . ID=CDS1;locus_tag=Rv2167c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2431094 2431420 . - . ID=CDS1;locus_tag=Rv2168c;product=Putative transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2431565 2431969 . - . ID=CDS1;locus_tag=Rv2169c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2432235 2432855 . + . ID=CDS1;locus_tag=Rv2170;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2432951 2433634 . + . ID=CDS1;locus_tag=Rv2171;product=Probable conserved lipoprotein LppM;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2433631 2434536 . - . ID=CDS1;locus_tag=Rv2172c;product=Conserved protein;Inference=profile:Phyre server structural modeling and prediction [PMID: 19247286]/note:FunctionalCategory: conserved hypotheticals/note:MetF homolog, putative lipoprotein/note:Predicted to be involved in membrane associated processes based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2434847 2435905 . + . ID=CDS1;locus_tag=Rv2173;product=Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2435909 2437459 . + . ID=CDS1;locus_tag=Rv2174;product=Alpha(1->6)mannosyltransferase. Possible conserved integral membrane protein.;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2437446 2437886 . - . ID=CDS1;locus_tag=Rv2175c;product=Probable transcriptional regulator of cell wall biosynthesis;Experiment=DESCRIPTION: Protein purification and expression in E. Coli, NMR, EMSA for non-specific Mtb DNA-binding Fluorescence Anisotropy [PMID: 19457863],Experiment=DESCRIPTION: Protein expression and purification, in vitro kinase/phosphorylation assay, Mass spectrometry, Western blot. [PMID: 18175374]/note:FunctionalCategory: regulatory proteins/note:Phosphorylated by PknL [PMID: 18175374]/note:regulated by Thr phosphorylation. [PMID: 19457863] chr1 CDS 2437941 2439140 . + . ID=CDS1;locus_tag=Rv2176;product=Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L);note=FunctionalCategory: regulatory proteins chr1 CDS 2439282 2439947 . - . ID=CDS1;locus_tag=Rv2177c;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2440332 2441720 . - . ID=CDS1;locus_tag=Rv2178c;product=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phenylalanine-repressible);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2441811 2442317 . - . ID=CDS1;locus_tag=Rv2179c;product=DEDD-type exoribonuclease;Experiment=DESCRIPTION:RNase assay, DNase assay, chemical proteomics, crystal structure determination [PMID: 24311791]/note:ATP-binding protein [PMID: 24311791]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.13.- chr1 CDS 2442327 2443214 . - . ID=CDS1;locus_tag=Rv2180c;product=Probable antigen;Experiment=DESCRIPTION:protein expression and purification, indirect ELISA [PMID: 20690665]/note:FunctionalCategory: cell wall and cell processes/note:co-transcribed with Rv2179c and Rv2178c (aroG) in an operon [PMID: 21256084]/note:antigenic protein [PMID: 20690665]/note:Conserved integral membrane protein [TubercuList] chr1 CDS 2443302 2444585 . + . ID=CDS1;locus_tag=Rv2181;product=Alpha(1->2)mannosyltransferase;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2444586 2445329 . - . ID=CDS1;locus_tag=Rv2182c;product=1-acylglycerol-3-phosphate O-acyltransferase;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2445415 2445810 . - . ID=CDS1;locus_tag=Rv2183c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Linked to cyclase activity based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2445807 2446946 . - . ID=CDS1;locus_tag=Rv2184c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, potential ATPase, identified by similarity of predicted tertiary structure to PDB:3igfB;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3igfB chr1 CDS 2447066 2447500 . - . ID=CDS1;locus_tag=Rv2185c;product=Conserved protein TB16.3/putative methyltransferase;Experiment=DESCRIPTION:expression of Mtb gene in HeLa cells, western blot, apoptosis assay [PMID: 25771181],Experiment=DESCRIPTION:protein isolation and precipitation, 2D-gel electrophoresis, in-gel digestion and mass spectrometry [PMID: 27895634]/inference:ab initio prediction:InterProScan [PMID: 27895634]/inference:ab initio prediction:Molecular docking [PMID: 27895634]/note:activates Nuclear factor-kB/induces IkB-alpha degradation [PMID: 25771181]/note:FunctionalCategory: conserved hypotheticals/note:over expressed in amikacin and kanamycin resistant isolates and the conserved domain of this gene is predicted to interact with these drugs [PMID: 27895634];EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2rezA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 2447605 2447994 . - . ID=CDS1;locus_tag=Rv2186c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Linked to cyclase activity based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2448160 2449962 . + . ID=CDS1;locus_tag=Rv2187;product=Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2449993 2451150 . - . ID=CDS1;locus_tag=Rv2188c;product=Mannosyltransferase PimB;note=FunctionalCategory: lipid metabolism chr1 CDS 2451247 2452020 . - . ID=CDS1;locus_tag=Rv2189c;product=Putative Antigen;Experiment=ELISPOT, Whole blood Assay, T-cell Depletion assay, Fc Receptor Blocking Assay, Phagocytosis by Flow Cytometry, Human Antibodies Isotyping Assay [PMID: 28438994]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 2452115 2453272 . - . ID=CDS1;locus_tag=Rv2190c;gene=ripC;product=peptidoglycan peptidase RipC/Antigen;Experiment=DESCRIPTION:protein purification and crystallization, protein interaction assays, isothermal titration calorimetry (ITC), proteolysis assays, activity assays, mutant construction via gene replacement [PMID: 24843173],Experiment=DESCRIPTION:mRNA expression, lysozyme and phthiocerol dimycocerosate enzyme assays, Dot-Blot assay, stress assay, time-to-death studies, in vivo growth and pathology studies [PMID: 22952680],Experiment=DESCRIPTION:protein recombination, vaccine construction, cytokine production, Bacterium counts, Lung histopathological examination. [PMID: 28241799]/note:FunctionalCategory: virulence, detoxification, adaptation/note:required for growth in M. tuberculosis [PMID: 22952680]/note:immunogenic during infection [PMID: 22952680]/note:peptidoglycan (PG) hydrolysis activity of this enzyme activated by FtsX ECD [PMID: 24843173]/note:NlpC/P60 family protein [PMID: 22952680]/note:required for full virulence of M.tuberculosis [22952680];EC_number=3.2.1.- chr1 CDS 2453819 2455756 . + . ID=CDS1;locus_tag=Rv2191;product=Conserved hypothetical protein;note=FunctionalCategory: information pathways chr1 CDS 2455631 2456743 . - . ID=CDS1;locus_tag=Rv2192c;product=Probable anthranilate phosphoribosyltransferase TrpD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2456901 2457512 . + . ID=CDS1;locus_tag=Rv2193;product=Probable cytochrome C oxidase (subunit III) CtaE;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2457553 2458395 . + . ID=CDS1;locus_tag=Rv2194;product=Probable ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2458392 2459681 . + . ID=CDS1;locus_tag=Rv2195;product=Probable rieske iron-sulfur protein QcrA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2459678 2461327 . + . ID=CDS1;locus_tag=Rv2196;product=Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2461504 2462148 . - . ID=CDS1;locus_tag=Rv2197c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2462148 2463047 . - . ID=CDS1;locus_tag=Rv2198c;product=Probable conserved membrane protein MmpS3;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2463233 2463652 . - . ID=CDS1;locus_tag=Rv2199c;product=putative glycoprotein;Experiment=DESCRIPTION: affinity two-phase partitioning, proteolytic digestion, Mass spectrometry, MS/MS [PMID: 22053987]/note:FunctionalCategory: cell wall and cell processes/note:highly enriched in WGA affinity fraction [PMID: 22053987] chr1 CDS 2463660 2464751 . - . ID=CDS1;locus_tag=Rv2200c;product=Probable transmembrane cytochrome C oxidase (subunit II) CtaC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2464997 2466955 . + . ID=CDS1;locus_tag=Rv2201;product=Probable asparagine synthetase AsnB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2467053 2468027 . - . ID=CDS1;locus_tag=Rv2202c;product=Adenosine kinase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2468231 2468923 . + . ID=CDS1;locus_tag=Rv2203;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2468931 2469287 . - . ID=CDS1;locus_tag=Rv2204c;product=probable serine hydrolase;Experiment=DESCRIPTION:recombinant DNA overexpression, enzyme-linked immunosorbent assay (ELISA) [PMID: 26298037],Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals/note:biomarker in Latent TB infection, can be identified using IFN-y response,Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.1.-.- chr1 CDS 2469387 2470463 . - . ID=CDS1;locus_tag=Rv2205c;product=Putative Glycerate 3-kinase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.1.31 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1to6A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1to6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1to6A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1to6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1to6A,Ontology_term=0008887/note:identified by similarity of predicted tertiary structure to PDB 1to6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1to6A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1to6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1to6A,Ontology_term=0016301/note:identified by similarity of predicted tertiary structure to PDB 1to6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1to6A,Ontology_term=0016310/note:identified by similarity of predicted tertiary structure to PDB 1to6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1to6A,Ontology_term=0031388/note:identified by similarity of predicted tertiary structure to PDB 1to6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1to6A chr1 CDS 2470622 2471332 . + . ID=CDS1;locus_tag=Rv2206;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, possibly involved in vitamin B12 biosynthesis pathway [PMID: 25690095] chr1 CDS 2471411 2472496 . + . ID=CDS1;locus_tag=Rv2207;product=Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2472493 2473242 . + . ID=CDS1;locus_tag=Rv2208;product=Probable cobalamin 5'-phosphate synthase CobS;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2473400 2474938 . + . ID=CDS1;locus_tag=Rv2209;product=Probable conserved integral membrane protein/putative MFS membrane transporter;note=FunctionalCategory: cell wall and cell processes, expression altered by Ofloxacin [PMID: 20001742], induced by RIF [PMID: 25690361], Structural similarity and full overlap with MFS transporter of E. coli crystallized and functionally characterized as a transporter, identified by similarity of predicted tertiary structure to PDB:3wdoA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wdoA chr1 CDS 2474864 2475970 . - . ID=CDS1;locus_tag=Rv2210c;product=Branched-chain amino acid transaminase IlvE;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2476042 2477145 . - . ID=CDS1;locus_tag=Rv2211c;product=Probable aminomethyltransferase GcvT (glycine cleavage system T protein);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2477190 2478326 . + . ID=CDS1;locus_tag=Rv2212;product=Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2478338 2479885 . + . ID=CDS1;locus_tag=Rv2213;product=Probable aminopeptidase PepB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2479923 2481701 . - . ID=CDS1;locus_tag=Rv2214c;product=Possible short-chain dehydrogenase EphD;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2481965 2483626 . + . ID=CDS1;locus_tag=Rv2215;product=DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2483626 2484531 . + . ID=CDS1;locus_tag=Rv2216;gene=madR1;product= Morphology altering division regulator protein 1 (MadR1)/putative carbohydrate epimerase/putative carbon-sulfur hydrolase;Experiment=DESCRIPTION:gene overexpression, localization using fluorescence microscopy [PMID: 25829286]/inference:similar to AA sequence:BLAST [PMID: 25829286]/note:FunctionalCategory: conserved hypotheticals/note:SulA-like protein [PMID: 25829286]/note:Overexpression induces adaptive dormancy-associated metabolic programs [PMID: 25829286];EC_number=5.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2c5aA,4ej0A,2p5uA,3lu1A,1sb8A,2x6tG,4zrmA,3enkA,1gy8C,1a9yA,1orrA,1ek5A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.13.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1qrrA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0051287/note:identified by similarity of predicted tertiary structure to PDB 2c5aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,Ontology_term=0097171/note:identified by similarity of predicted tertiary structure to PDB 4ej0A,2x6tG/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ej0A,2x6tG,Ontology_term=0047732/note:identified by similarity of predicted tertiary structure to PDB 1orrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1orrA,Ontology_term=0003974/note:identified by similarity of predicted tertiary structure to PDB 3lu1A,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3lu1A,1ek5A,Ontology_term=0003978/note:identified by similarity of predicted tertiary structure to PDB 3enkA,1gy8C,1a9yA,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3enkA,1gy8C,1a9yA,1ek5A,Ontology_term=0009103/note:identified by similarity of predicted tertiary structure to PDB 2x6tG,1orrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x6tG,1orrA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1a9yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a9yA,Ontology_term=0050662/note:identified by similarity of predicted tertiary structure to PDB 2c5aA,4ej0A,2p5uA,3lu1A,1sb8A,2x6tG,4zrmA,1gy8C,1qrrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,4ej0A,2p5uA,3lu1A,1sb8A,2x6tG,4zrmA,1gy8C,1qrrA,Ontology_term=0050661/note:identified by similarity of predicted tertiary structure to PDB 4ej0A,2x6tG/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ej0A,2x6tG,Ontology_term=0019388/note:identified by similarity of predicted tertiary structure to PDB 1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ek5A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ek5A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2x6tG/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x6tG,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2c5aA,2p5uA,3lu1A,1sb8A,4zrmA,3enkA,1gy8C/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,2p5uA,3lu1A,1sb8A,4zrmA,3enkA,1gy8C,Ontology_term=0006012/note:identified by similarity of predicted tertiary structure to PDB 3enkA,1gy8C,1a9yA,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3enkA,1gy8C,1a9yA,1ek5A,Ontology_term=0033499/note:identified by similarity of predicted tertiary structure to PDB 1a9yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a9yA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1a9yA,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a9yA,1ek5A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ek5A,Ontology_term=0019853/note:identified by similarity of predicted tertiary structure to PDB 2c5aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,Ontology_term=0009243/note:identified by similarity of predicted tertiary structure to PDB 3lu1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3lu1A,Ontology_term=0009242/note:identified by similarity of predicted tertiary structure to PDB 1a9yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a9yA,Ontology_term=0009244/note:identified by similarity of predicted tertiary structure to PDB 2x6tG/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x6tG,Ontology_term=0008712/note:identified by similarity of predicted tertiary structure to PDB 4ej0A,2x6tG/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ej0A,2x6tG,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2c5aA,4ej0A,2p5uA,3lu1A,1sb8A,2x6tG,4zrmA,1gy8C,1qrrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,4ej0A,2p5uA,3lu1A,1sb8A,2x6tG,4zrmA,1gy8C,1qrrA,Ontology_term=0047918/note:identified by similarity of predicted tertiary structure to PDB 2c5aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,Ontology_term=0016857/note:identified by similarity of predicted tertiary structure to PDB 3lu1A,1sb8A,4zrmA,1a9yA,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3lu1A,1sb8A,4zrmA,1a9yA,1ek5A,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 4ej0A,3lu1A,1sb8A,2x6tG,4zrmA,1a9yA,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ej0A,3lu1A,1sb8A,2x6tG,4zrmA,1a9yA,1ek5A,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 2c5aA,4ej0A,3lu1A,2x6tG,3enkA,1gy8C,1a9yA,1orrA,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,4ej0A,3lu1A,2x6tG,3enkA,1gy8C,1a9yA,1orrA,1ek5A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2c5aA,2x6tG,1a9yA,1ek5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c5aA,2x6tG,1a9yA,1ek5A,Ontology_term=0070401/note:identified by similarity of predicted tertiary structure to PDB 2x6tG/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x6tG,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2x6tG,1a9yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2x6tG,1a9yA,Ontology_term=0070403/note:identified by similarity of predicted tertiary structure to PDB 1a9yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a9yA chr1 CDS 2484584 2485276 . + . ID=CDS1;locus_tag=Rv2217;product=Probable lipoate biosynthesis protein B LipB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2485273 2486208 . + . ID=CDS1;locus_tag=Rv2218;product=Probable lipoate biosynthesis protein A LipA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2486235 2486987 . + . ID=CDS1;locus_tag=Rv2219;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2486994 2487416 . - . ID=CDS1;locus_tag=Rv2219A;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2487615 2489051 . + . ID=CDS1;locus_tag=Rv2220;product=Glutamine synthetase GlnA1 (glutamine synthase) (GS-I);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2489369 2492353 . - . ID=CDS1;locus_tag=Rv2221c;product=Glutamate-ammonia-ligase adenylyltransferase GlnE (glutamine-synthetase adenylyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2492402 2493742 . - . ID=CDS1;locus_tag=Rv2222c;product=Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2493837 2495399 . - . ID=CDS1;locus_tag=Rv2223c;product=Probable exported protease;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2495461 2497023 . - . ID=CDS1;locus_tag=Rv2224c;product=Probable carboxylesterase CaeA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2497742 2498587 . + . ID=CDS1;locus_tag=Rv2225;product=3-methyl-2-oxobutanoate hydroxymethyltransferase PanB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2498832 2500373 . + . ID=CDS1;locus_tag=Rv2226;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2500931 2501632 . + . ID=CDS1;locus_tag=Rv2227;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2501644 2502738 . - . ID=CDS1;locus_tag=Rv2228c;product=Multifunctional protein. Has RNASE H, alpha-ribazole phosphatase, and acid phosphatase activities.;note=FunctionalCategory: information pathways chr1 CDS 2502735 2503472 . - . ID=CDS1;locus_tag=Rv2229c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2503469 2504608 . - . ID=CDS1;locus_tag=Rv2230c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in DNA-associated processes based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2504605 2505699 . - . ID=CDS1;locus_tag=Rv2231c;product=Possible aminotransferase CobC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2505736 2506161 . - . ID=CDS1;locus_tag=Rv2231A;product=Possible toxin VapC16;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2506207 2506383 . - . ID=CDS1;locus_tag=Rv2231B;product=Possible antitoxin VapB16;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2506428 2507153 . + . ID=CDS1;locus_tag=Rv2232;product=Protein tyrosine kinase transcriptional regulatory protein PtkA;note=FunctionalCategory: regulatory proteins;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2507146 2507637 . + . ID=CDS1;locus_tag=Rv2234;product=Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase);note=FunctionalCategory: regulatory proteins chr1 CDS 2507637 2508452 . + . ID=CDS1;locus_tag=Rv2235;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2508434 2509375 . - . ID=CDS1;locus_tag=Rv2236c;product=Probable cobalamin biosynthesis transmembrane protein CobD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2509489 2510256 . + . ID=CDS1;locus_tag=Rv2237;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2510351 2510587 . - . ID=CDS1;locus_tag=Rv2237A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2510715 2511176 . - . ID=CDS1;locus_tag=Rv2238c;product=Probable peroxiredoxin AhpE;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2511176 2511598 . - . ID=CDS1;locus_tag=Rv2239c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in cell redox homeostasis based on evidence from STRING database (protein-protein interactions)[PMID: 22485162];Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2511690 2512280 . - . ID=CDS1;locus_tag=Rv2240c;product=conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2512539 2515244 . + . ID=CDS1;locus_tag=Rv2241;product=Pyruvate dehydrogenase E1 component AceE (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2515304 2516548 . + . ID=CDS1;locus_tag=Rv2242;gene=mabR;product=transcriptional regulator (repressor) of fasII operon/Mycolic acid biosynthesis regulator (MabR);Experiment=DESCRIPTION:southern blot, chromatin immunoprecipitation, gene knockdown and overexpression in M.smegmatis [PMID: 20659288]/inference:similar to AA sequence:BLAST[PMID: 20659288]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 2516787 2517695 . + . ID=CDS1;locus_tag=Rv2243;product=Malonyl CoA-acyl carrier protein transacylase FabD (malonyl CoA:ACPM acyltransferase) (MCT);note=FunctionalCategory: lipid metabolism chr1 CDS 2517771 2518118 . + . ID=CDS1;locus_tag=Rv2244;product=Meromycolate extension acyl carrier protein AcpM;note=FunctionalCategory: lipid metabolism chr1 CDS 2518115 2519365 . + . ID=CDS1;locus_tag=Rv2245;product=3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I);note=FunctionalCategory: lipid metabolism chr1 CDS 2519396 2520712 . + . ID=CDS1;locus_tag=Rv2246;product=3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I);note=FunctionalCategory: lipid metabolism chr1 CDS 2520743 2522164 . + . ID=CDS1;locus_tag=Rv2247;product=Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2522360 2523175 . + . ID=CDS1;locus_tag=Rv2248;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2523241 2524791 . - . ID=CDS1;locus_tag=Rv2249c;product=Probable glycerol-3-phosphate dehydrogenase GlpD1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2524785 2525354 . - . ID=CDS1;locus_tag=Rv2250c;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0032993/note:identified by similarity of predicted tertiary structure to PDB 2uxuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxuA,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2f07A,2id3A,1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f07A,2id3A,1u9nA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2f07A,1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f07A,1u9nA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2f07A,2id3A,2uxuA,1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f07A,2id3A,2uxuA,1u9nA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2f07A,2id3A,2uxuA,1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f07A,2id3A,2uxuA,1u9nA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2f07A,2id3A,2uxuA,1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f07A,2id3A,2uxuA,1u9nA,Ontology_term=0045892/note:identified by similarity of predicted tertiary structure to PDB 1u9nA,2uxuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u9nA,2uxuA,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 2f07A,2uxuA,1u9nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f07A,2uxuA,1u9nA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2id3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2id3A,Ontology_term=0001217/note:identified by similarity of predicted tertiary structure to PDB 2uxuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxuA chr1 CDS 2525402 2525821 . + . ID=CDS1;locus_tag=Rv2250A;product=Possible flavoprotein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2525565 2526992 . + . ID=CDS1;locus_tag=Rv2251;product=Possible flavoprotein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2526989 2527918 . + . ID=CDS1;locus_tag=Rv2252;product=Diacylglycerol kinase;note=FunctionalCategory: lipid metabolism chr1 CDS 2527984 2528487 . + . ID=CDS1;locus_tag=Rv2253;product=Possible secreted unknown protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2528520 2528975 . - . ID=CDS1;locus_tag=Rv2254c;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2528980 2529174 . - . ID=CDS1;locus_tag=Rv2255c;product=hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2529341 2529874 . - . ID=CDS1;locus_tag=Rv2256c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2530004 2530822 . - . ID=CDS1;locus_tag=Rv2257c;product=Putative peptidase/putative acyltransferase;Inference=alignment:multiple sequence alignment using ClustalW-MPI, metabolic pathway reconstruction using Pathway Tools version 14.0 with MetaCyc[PMID: 21573108]/note:FunctionalCategory: conserved hypotheticals/note:putative role in antibiotic Resistance;EC_number=3.4.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1ei5A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.4.16.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1cefA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2zm9A/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.3.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3hlgA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004177/note:identified by similarity of predicted tertiary structure to PDB 1ei5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 3hlgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hlgA,Ontology_term=0009252/note:identified by similarity of predicted tertiary structure to PDB 1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cefA,Ontology_term=0009002/note:identified by similarity of predicted tertiary structure to PDB 1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cefA,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 1ei5A,1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,1cefA,Ontology_term=0019876/note:identified by similarity of predicted tertiary structure to PDB 2zm9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zm9A,Ontology_term=0004180/note:identified by similarity of predicted tertiary structure to PDB 1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cefA,Ontology_term=0019875/note:identified by similarity of predicted tertiary structure to PDB 2zm9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zm9A,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cefA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3hlgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hlgA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 3hlgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hlgA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 1ei5A,1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,1cefA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1ei5A,1cefA,2zm9A,3hlgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ei5A,1cefA,2zm9A,3hlgA,Ontology_term=0050832/note:identified by similarity of predicted tertiary structure to PDB 3hlgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hlgA,Ontology_term=0008360/note:identified by similarity of predicted tertiary structure to PDB 1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cefA,Ontology_term=0030639/note:identified by similarity of predicted tertiary structure to PDB 3hlgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hlgA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1cefA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cefA chr1 CDS 2530836 2531897 . - . ID=CDS1;locus_tag=Rv2258c;product=Probable S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase);Experiment=DESCRIPTION: Protein expression and purification, Crystallization, X-ray diffraction, gel filtration chromatography [PMID: 26772148]/note:FunctionalCategory: regulatory proteins,Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=2.1.1.- chr1 CDS 2532245 2533330 . + . ID=CDS1;locus_tag=Rv2259;product=S-nitrosomycothiol reductase MscR;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2533330 2533965 . + . ID=CDS1;locus_tag=Rv2260;product=putative dioxygenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.13.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4chlA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0050313/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0006749/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0005506/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0070221/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA,Ontology_term=0070813/note:identified by similarity of predicted tertiary structure to PDB 4chlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4chlA chr1 CDS 2534042 2534464 . - . ID=CDS1;locus_tag=Rv2261c;product=putative linear amide hydrolase;Inference=alignment:Needleman-Wunsch [PMID: 24093492]/inference:similar to AA sequence:Blastp [PMID: 24093492]/note:potential apolipoprotein N-acyltransferase (Lnt)/note:FunctionalCategory: lipid metabolism/note:Gene is homologous but frameshifted in H37Rv, splitting into two ORFs (Rv2262c) but is homologous in CDC1551;EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2plqA,5h8iA,2gglA,2dyvA,3hkxA,2vhhC/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006596/note:identified by similarity of predicted tertiary structure to PDB 5h8iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5h8iA,Ontology_term=0006807/note:identified by similarity of predicted tertiary structure to PDB 2plqA,5h8iA,2gglA,2dyvA,3hkxA,2vhhC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2plqA,5h8iA,2gglA,2dyvA,3hkxA,2vhhC,Ontology_term=0004328/note:identified by similarity of predicted tertiary structure to PDB 2dyvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dyvA,Ontology_term=0006208/note:identified by similarity of predicted tertiary structure to PDB 2vhhC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vhhC,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2plqA,5h8iA,2gglA,2dyvA,2vhhC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2plqA,5h8iA,2gglA,2dyvA,2vhhC,Ontology_term=0004040/note:identified by similarity of predicted tertiary structure to PDB 2plqA,3hkxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2plqA,3hkxA,Ontology_term=0003837/note:identified by similarity of predicted tertiary structure to PDB 2vhhC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vhhC,Ontology_term=0016810/note:identified by similarity of predicted tertiary structure to PDB 2plqA,5h8iA,2gglA,2dyvA,3hkxA,2vhhC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2plqA,5h8iA,2gglA,2dyvA,3hkxA,2vhhC,Ontology_term=0047417/note:identified by similarity of predicted tertiary structure to PDB 2gglA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gglA,Ontology_term=0006207/note:identified by similarity of predicted tertiary structure to PDB 2vhhC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vhhC,Ontology_term=0050126/note:identified by similarity of predicted tertiary structure to PDB 5h8iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5h8iA chr1 CDS 2534470 2535552 . - . ID=CDS1;locus_tag=Rv2262c;product=Conserved hypothetical protein;Inference=alignment:Needleman-Wunsch [PMID: 24093492]/inference:similar to AA sequence:Blastp [PMID: 24093492]/note:FunctionalCategory: lipid metabolism/note:potential apolipoprotein N-acyltransferase (Lnt) [PMID: 24093492]/note:Gene is homologous but frameshifted in H37Rv, splitting into two ORFs (Rv2261c). It is homologous in CDC1551, however. chr1 CDS 2535641 2536594 . + . ID=CDS1;locus_tag=Rv2263;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2536572 2538350 . - . ID=CDS1;locus_tag=Rv2264c;product=putative phosphorous-anhydride hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.-;Ontology_term=0006452/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=1990090/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0051087/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005783/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=1990440/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0035437/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0009314/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0030433/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0019904/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005788/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005789/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0051603/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0042149/note:identified by similarity of predicted tertiary structure to PDB 5tkyA,5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,5e84A,Ontology_term=0035690/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0021762/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0016887/note:identified by similarity of predicted tertiary structure to PDB 5tkyA,5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,5e84A,Ontology_term=0045296/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0034663/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005925/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=1901998/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0036500/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0008180/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 5tkyA,5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,5e84A,Ontology_term=0006987/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0030182/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0006983/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0043209/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0071353/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0051082/note:identified by similarity of predicted tertiary structure to PDB 5tkyA,5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,5e84A,Ontology_term=0051083/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0043066/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005509/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0031398/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0002181/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=1904313/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 5tkyA,5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,5e84A,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0030335/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0071236/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005790/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005793/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005844/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0097501/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 5tkyA,5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,5e84A,Ontology_term=0009986/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0071277/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0021680/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0036498/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0036499/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0051402/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0031625/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0019899/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0042220/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0031012/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0030512/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0010494/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0042470/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0043022/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0006450/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0060904/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0030968/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0071287/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0071320/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0030496/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0000054/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0090074/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0021589/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=1903897/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=1903894/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0030176/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0051787/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=1903891/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0034976/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0034975/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A,Ontology_term=0006412/note:identified by similarity of predicted tertiary structure to PDB 5tkyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5tkyA,Ontology_term=0010976/note:identified by similarity of predicted tertiary structure to PDB 5e84A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e84A chr1 CDS 2538700 2539929 . + . ID=CDS1;locus_tag=Rv2265;product=Possible conserved integral membrane protein/putative membrane transporter;note=FunctionalCategory: cell wall and cell processes, down-regulated upon Rv1747 deletion [PMID: 23915284], probably expressed at a lower level in MDR isolates [PMID: 25695504], Structural similarity and full overlap with MFS transporter of E. coli crystallized and functionally characterized as a transporter, identified by similarity of predicted tertiary structure to PDB:4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 5c65A, 3o7pA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 5c65A, 3o7pA chr1 CDS 2540104 2541390 . + . ID=CDS1;locus_tag=Rv2266;product=Probable cytochrome P450 124 Cyp124;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2541644 2542810 . - . ID=CDS1;locus_tag=Rv2267c;gene=stf3;product=Probable sulfotransferase;Experiment=DESCRIPTION:gene knockout, Southern Blot, mass spectometry [PMID: 16537518]/inference:similar to AA sequence:Pfam, pairwise similarity search [PMID: 12144918]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to negatively regulate virulence of Mycobacterium tuberculosis [PMID: 16537518];EC_number=2.8.2.- chr1 CDS 2542807 2544276 . - . ID=CDS1;locus_tag=Rv2268c;product=Probable cytochrome P450 128 Cyp128;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2544289 2544621 . - . ID=CDS1;locus_tag=Rv2269c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2544698 2545225 . + . ID=CDS1;locus_tag=Rv2270;product=Probable lipoprotein LppN;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2545332 2545631 . + . ID=CDS1;locus_tag=Rv2271;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2545737 2546105 . + . ID=CDS1;locus_tag=Rv2272;product=Probable gamma delta T-cell activator;Experiment=DESCRIPTION:protein expression, flow cytometry, ELISA, CCK-8 and MTT assays [PMID: 23389928]/note:FunctionalCategory: cell wall and cell processes/note:Probable conserved transmembrane protein. [TubercuList];Inference=similar to AA sequence:BLASTp [PMID: 23389928]/inference:ab initio prediction:HMMTOP [PMID: 23389928] chr1 CDS 2546102 2546431 . + . ID=CDS1;locus_tag=Rv2273;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, induced and exported in vivo [PMID: 28442606] chr1 CDS 2546488 2546805 . - . ID=CDS1;locus_tag=Rv2274c;product=Possible toxin MazF8;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2546839 2547087 . - . ID=CDS1;locus_tag=Rv2274A;product=Possible antitoxin MazE8;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2546883 2547752 . + . ID=CDS1;locus_tag=Rv2275;product=cyclodityrosine synthetase;Experiment=DESCRIPTION:protein purification, end-point assay, reverse phase HPLC, site-directed mutagenesis, radioactive labeling, X-ray Crystallography [PMID: 20852636]/note:FunctionalCategory: conserved hypotheticals/note:structurally related to class Ic aminoacyl-tRNA synthetases;EC_number=2.3.2.21 chr1 CDS 2547749 2548939 . + . ID=CDS1;locus_tag=Rv2276;product=Cytochrome P450 121 Cyp121;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2549124 2550029 . - . ID=CDS1;locus_tag=Rv2277c;product=Possible glycerolphosphodiesterase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2550065 2550391 . + . ID=CDS1;locus_tag=Rv2278;product=Putative transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2550340 2551326 . + . ID=CDS1;locus_tag=Rv2279;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2551560 2552939 . + . ID=CDS1;locus_tag=Rv2280;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2553173 2554831 . + . ID=CDS1;locus_tag=Rv2281;product=Putative phosphate-transport permease PitB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2554938 2555876 . - . ID=CDS1;locus_tag=Rv2282c;product=Probable transcription regulator (LysR family);note=FunctionalCategory: regulatory proteins chr1 CDS 2555941 2556135 . + . ID=CDS1;locus_tag=Rv2283;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2556145 2557440 . + . ID=CDS1;locus_tag=Rv2284;product=Probable esterase LipM;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2557473 2558810 . + . ID=CDS1;locus_tag=Rv2285;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 2558877 2559569 . - . ID=CDS1;locus_tag=Rv2286c;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 4nxiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nxiA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4nxiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nxiA,Ontology_term=0015035/note:identified by similarity of predicted tertiary structure to PDB 4nxiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nxiA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4nxiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nxiA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4nxiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4nxiA chr1 CDS 2559703 2561331 . + . ID=CDS1;locus_tag=Rv2287;product=Probable conserved integral membrane transport protein YjcE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2561328 2561705 . + . ID=CDS1;locus_tag=Rv2288;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2561675 2562457 . + . ID=CDS1;locus_tag=Rv2289;product=Probable CDP-diacylglycerol pyrophosphatase Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase);note=FunctionalCategory: lipid metabolism chr1 CDS 2562599 2563114 . + . ID=CDS1;locus_tag=Rv2290;product=Probable conserved lipoprotein LppO;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2563174 2564028 . + . ID=CDS1;locus_tag=Rv2291;product=Probable thiosulfate sulfurtransferase SseB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2564029 2564253 . - . ID=CDS1;locus_tag=Rv2292c;product=putative adenosylhomocysteine nucleosidase/putative methylthioadenosine nucleosidase;note=FunctionalCategory: unknown;EC_number=3.2.2.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0019509/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0008930/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0008652/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0008782/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0016798/note:identified by similarity of predicted tertiary structure to PDB 1zosA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0009164/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0009116/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1zosA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,Ontology_term=0009086/note:identified by similarity of predicted tertiary structure to PDB 1zosA,5dk6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zosA,5dk6A chr1 CDS 2564292 2565032 . - . ID=CDS1;locus_tag=Rv2293c;product=putative nucleosidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.2.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0009234/note:identified by similarity of predicted tertiary structure to PDB 3nm4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nm4A,Ontology_term=0016798/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,4jwtA,4josA,3eeiA,1zosA,4kn5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,4jwtA,4josA,3eeiA,1zosA,4kn5A,Ontology_term=0009164/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0019284/note:identified by similarity of predicted tertiary structure to PDB 3eeiA,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eeiA,1nc3A,Ontology_term=0019509/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0000003/note:identified by similarity of predicted tertiary structure to PDB 2qttA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qttA,Ontology_term=0008782/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0001944/note:identified by similarity of predicted tertiary structure to PDB 2qttA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qttA,Ontology_term=0102246/note:identified by similarity of predicted tertiary structure to PDB 3nm4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3nm4A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0008930/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0009116/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,4g41A,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,4jwtA,4josA,3eeiA,1zosA,4kn5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,4jwtA,4josA,3eeiA,1zosA,4kn5A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2qttA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qttA,Ontology_term=0008652/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2qttA,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qttA,1nc3A,Ontology_term=0009086/note:identified by similarity of predicted tertiary structure to PDB 4l0mA,2qttA,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l0mA,2qttA,3bl6A,3nm4A,4jwtA,5dk6A,4qezB,4josA,3eeiA,3dp9C,1zosA,4kn5A,1nc3A chr1 CDS 2565327 2566550 . + . ID=CDS1;locus_tag=Rv2294;product=Probable aminotransferase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2566772 2567410 . + . ID=CDS1;locus_tag=Rv2295;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2567504 2568406 . + . ID=CDS1;locus_tag=Rv2296;product=Probable haloalkane dehalogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2568438 2568890 . + . ID=CDS1;locus_tag=Rv2297;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2569082 2570053 . + . ID=CDS1;locus_tag=Rv2298;product=Conserved protein/putative aldo-keto reductase;Experiment=DESCRIPTION:Mass spectrometry identification [PMID: 20975714]/note:FunctionalCategory: conserved hypotheticals/note:possible methylglyoxal reductase, glyoxylase, aldo/ketoreductase;EC_number=1.3.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3g1rA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005496/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0004033/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0047787/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0030573/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0006699/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0008209/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0008207/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0008202/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0006707/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0007586/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA chr1 CDS 2570059 2572002 . - . ID=CDS1;locus_tag=Rv2299c;product=Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2572076 2573008 . - . ID=CDS1;locus_tag=Rv2300c;product=Conserved protein/putative phosphoric triester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.8.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1p9eA,4le6A/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 2573015 2573707 . + . ID=CDS1;locus_tag=Rv2301;product=Probable cutinase Cut2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2573813 2574055 . + . ID=CDS1;locus_tag=Rv2302;product=Conserved protein;Experiment=DESCRIPTION:nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy [PMID: 16885468]/note:FunctionalCategory: conserved hypotheticals/note:upregulated in response to starvation and overexpression of heat shock proteins [PMID: 16885468] chr1 CDS 2574096 2575019 . - . ID=CDS1;locus_tag=Rv2303c;product=Probable antibiotic-resistance protein;note=FunctionalCategory: virulence, detoxification, adaptation;EC_number=3.-.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3irsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3irsA chr1 CDS 2575016 2575225 . - . ID=CDS1;locus_tag=Rv2304c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2575809 2577098 . + . ID=CDS1;locus_tag=Rv2305;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2577108 2577701 . + . ID=CDS1;locus_tag=Rv2306A;product=Possible conserved membrane protein/putative drug transport protein (efflux pump);note=FunctionalCategory: cell wall and cell processes;Ontology_term=0015307/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0006855/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 4mt1A,2j8sA,4mt1A2,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4mt1A,2j8sA,4mt1A2,2j8sA3,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0005215/note:identified by similarity of predicted tertiary structure to PDB 4mt1A,2j8sA,4mt1A2,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4mt1A,2j8sA,4mt1A2,2j8sA3,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4mt1A,2j8sA,4mt1A2,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4mt1A,2j8sA,4mt1A2,2j8sA3,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4mt1A,2j8sA,4mt1A2,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4mt1A,2j8sA,4mt1A2,2j8sA3,Ontology_term=0042493/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=1990281/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0015238/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0005887/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0046618/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2j8sA,2j8sA3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j8sA,2j8sA3 chr1 CDS 2577488 2577922 . + . ID=CDS1;locus_tag=Rv2306B;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2577851 2578696 . - . ID=CDS1;locus_tag=Rv2307c;product=putative carboxylic ester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1vlqL,3fcyA,3wj1A,3pf8A,1k8qA,3fvrA,4zwnA,3aikA,1aknA,4ypvA,2c7bA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0047739/note:identified by similarity of predicted tertiary structure to PDB 1vlqL/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,Ontology_term=0005783/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0046555/note:identified by similarity of predicted tertiary structure to PDB 1vlqL/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,Ontology_term=0008126/note:identified by similarity of predicted tertiary structure to PDB 3fvrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fvrA,Ontology_term=0030245/note:identified by similarity of predicted tertiary structure to PDB 1vlqL/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0005811/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1vlqL,4zwnA,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,4zwnA,1aknA,Ontology_term=0009966/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0006641/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 1k8qA,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,1aknA,Ontology_term=0005741/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0005509/note:identified by similarity of predicted tertiary structure to PDB 1vlqL/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1vlqL,3fcyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,3fcyA,Ontology_term=0004771/note:identified by similarity of predicted tertiary structure to PDB 1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1aknA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3aikA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3aikA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1vlqL,3wj1A,3pf8A,1k8qA,3fvrA,4zwnA,3aikA,1aknA,4ypvA,2c7bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,3wj1A,3pf8A,1k8qA,3fvrA,4zwnA,3aikA,1aknA,4ypvA,2c7bA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 1k8qA,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,1aknA,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 1vlqL,3aikA,1aknA,2c7bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,3aikA,1aknA,2c7bA,Ontology_term=0000272/note:identified by similarity of predicted tertiary structure to PDB 1vlqL/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,Ontology_term=0016788/note:identified by similarity of predicted tertiary structure to PDB 1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1vlqL,3wj1A,3aikA,4ypvA,2c7bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,3wj1A,3aikA,4ypvA,2c7bA,Ontology_term=0004806/note:identified by similarity of predicted tertiary structure to PDB 1k8qA,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,1aknA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 1vlqL/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,Ontology_term=0005976/note:identified by similarity of predicted tertiary structure to PDB 1vlqL/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vlqL,Ontology_term=0019433/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1k8qA,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,1aknA,Ontology_term=0047372/note:identified by similarity of predicted tertiary structure to PDB 4zwnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zwnA chr1 CDS 2579228 2579419 . - . ID=CDS1;locus_tag=Rv2307A;product=Hypothetical glycine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2579504 2579935 . - . ID=CDS1;locus_tag=Rv2307B;product=Hypothetical glycine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2580028 2580210 . - . ID=CDS1;locus_tag=Rv2307D;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2580419 2581135 . + . ID=CDS1;locus_tag=Rv2308;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2581843 2582298 . - . ID=CDS1;locus_tag=Rv2309c;product=Possible integrase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2583045 2583332 . + . ID=CDS1;locus_tag=Rv2309A;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2583435 2583779 . + . ID=CDS1;locus_tag=Rv2310;product=Possible excisionase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2583884 2584408 . + . ID=CDS1;locus_tag=Rv2311;product=putative ATPase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.4.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3gp8A,5ftbA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 5ftbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ftbA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 5ftbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ftbA,Ontology_term=0006281/note:identified by similarity of predicted tertiary structure to PDB 5ftbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ftbA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3gp8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gp8A,Ontology_term=0003678/note:identified by similarity of predicted tertiary structure to PDB 5ftbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ftbA,Ontology_term=0043141/note:identified by similarity of predicted tertiary structure to PDB 3gp8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gp8A,Ontology_term=0000723/note:identified by similarity of predicted tertiary structure to PDB 5ftbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ftbA,Ontology_term=0032508/note:identified by similarity of predicted tertiary structure to PDB 3gp8A,5ftbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gp8A,5ftbA chr1 CDS 2584486 2584755 . + . ID=CDS1;locus_tag=Rv2312;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2585052 2585906 . - . ID=CDS1;locus_tag=Rv2313c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2585917 2587290 . - . ID=CDS1;locus_tag=Rv2314c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2587287 2588804 . - . ID=CDS1;locus_tag=Rv2315c;product=putative peptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.-.-;Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 1vpbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vpbA,Ontology_term=0008237/note:identified by similarity of predicted tertiary structure to PDB 1vpbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vpbA chr1 CDS 2588838 2589710 . + . ID=CDS1;locus_tag=Rv2316;product=Probable sugar-transport integral membrane protein ABC transporter UspA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2589697 2590521 . + . ID=CDS1;locus_tag=Rv2317;product=Probable sugar-transport integral membrane protein ABC transporter UspB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2590518 2591840 . + . ID=CDS1;locus_tag=Rv2318;product=Probable periplasmic sugar-binding lipoprotein UspC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2591848 2592726 . - . ID=CDS1;locus_tag=Rv2319c;product=Universal stress protein family protein;Experiment=DESCRIPTION:gel electrophoresis and in-gel protein digestion, mass spectrometry [PMID: 21261938],Experiment=DESCRIPTION:ATP binding assay (using labeled ATP), mass spectrometry [PMID: 23462205]/note:FunctionalCategory: virulence, detoxification, adaptation/note:Protein predicted to be strain (H37Rv) specific (not found in H37Ra) [PMID: 21261938]/note:binds ATP [PMID: 23462205] chr1 CDS 2592723 2594153 . - . ID=CDS1;locus_tag=Rv2320c;product=Probable cationic amino acid transport integral membrane protein RocE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2594154 2594699 . - . ID=CDS1;locus_tag=Rv2321c;product=Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2594699 2595364 . - . ID=CDS1;locus_tag=Rv2322c;product=Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2595361 2596269 . - . ID=CDS1;locus_tag=Rv2323c;product=probable arginine metabolism/catabolism protein/probable arginine metabolism protein/putative linear amidine deiminase;Experiment=DESCRIPTION:gene knockout in vivo [PMID: 26368558]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.5.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5hp5A,2cmuA,1ynhB,2jerD,3bpbA,4bofA,4ytbA,1s9rA,2jajB,1rxxC,2dewX,2ewoH/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0045766/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0016597/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0016990/note:identified by similarity of predicted tertiary structure to PDB 4bofA,1s9rA,1rxxC,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bofA,1s9rA,1rxxC,2dewX,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3bpbA,2jajB,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bpbA,2jajB,2dewX,Ontology_term=0009446/note:identified by similarity of predicted tertiary structure to PDB 2cmuA,2jerD,4ytbA,2ewoH/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cmuA,2jerD,4ytbA,2ewoH,Ontology_term=0047632/note:identified by similarity of predicted tertiary structure to PDB 2jerD,2ewoH/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jerD,2ewoH,Ontology_term=0043234/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0019827/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2jajB,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2jajB,2dewX,Ontology_term=0002376/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0016569/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0003073/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2dewX,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,1ynhB,2jerD,3bpbA,4bofA,1s9rA,2jajB,1rxxC,2dewX,2ewoH/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,1ynhB,2jerD,3bpbA,4bofA,1s9rA,2jajB,1rxxC,2dewX,2ewoH,Ontology_term=0016403/note:identified by similarity of predicted tertiary structure to PDB 3bpbA,2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bpbA,2jajB,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0009015/note:identified by similarity of predicted tertiary structure to PDB 1ynhB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ynhB,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0045429/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,4bofA,1s9rA,1rxxC,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,4bofA,1s9rA,1rxxC,2dewX,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2dewX,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0019545/note:identified by similarity of predicted tertiary structure to PDB 1ynhB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ynhB,Ontology_term=0005509/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2dewX,Ontology_term=0019547/note:identified by similarity of predicted tertiary structure to PDB 4bofA,1s9rA,1rxxC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bofA,1s9rA,1rxxC,Ontology_term=0019546/note:identified by similarity of predicted tertiary structure to PDB 1rxxC,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rxxC,2dewX,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0008285/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=1900038/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0006338/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0006334/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0000052/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0004668/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2cmuA,2jerD,4ytbA,2dewX,2ewoH/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2cmuA,2jerD,4ytbA,2dewX,2ewoH,Ontology_term=0018101/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,4bofA,1s9rA,1rxxC,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,4bofA,1s9rA,1rxxC,2dewX,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2jajB,Ontology_term=0006325/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2dewX,Ontology_term=0006527/note:identified by similarity of predicted tertiary structure to PDB 1ynhB,4bofA,1s9rA,2jajB,1rxxC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ynhB,4bofA,1s9rA,2jajB,1rxxC,Ontology_term=0006525/note:identified by similarity of predicted tertiary structure to PDB 1ynhB,4bofA,1s9rA,2jajB,1rxxC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ynhB,4bofA,1s9rA,2jajB,1rxxC,Ontology_term=0034618/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0036413/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0036414/note:identified by similarity of predicted tertiary structure to PDB 5hp5A,2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hp5A,2dewX,Ontology_term=0045087/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0006464/note:identified by similarity of predicted tertiary structure to PDB 2dewX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dewX,Ontology_term=0007263/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0050999/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB,Ontology_term=0043116/note:identified by similarity of predicted tertiary structure to PDB 2jajB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2jajB chr1 CDS 2596334 2596780 . + . ID=CDS1;locus_tag=Rv2324;product=Probable transcriptional regulatory protein (probably AsnC-family);note=FunctionalCategory: regulatory proteins chr1 CDS 2597009 2597857 . - . ID=CDS1;locus_tag=Rv2325c;product=putative transport protein;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0005215/note:identified by similarity of predicted tertiary structure to PDB 5d3mD,4huqT/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d3mD,4huqT,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 5d3mD,4huqT/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d3mD,4huqT,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 5d3mD,4huqT/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d3mD,4huqT,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 5d3mD,4huqT/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d3mD,4huqT,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 5d3mD,4huqT/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5d3mD,4huqT chr1 CDS 2597854 2599947 . - . ID=CDS1;locus_tag=Rv2326c;product=Possible transmembrane ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2599988 2600479 . + . ID=CDS1;locus_tag=Rv2327;product=probable MarR transcriptional repressor;Experiment=DESCRIPTION:DNA-binding assays/pull-down assays, LC-ES tandem mass spectrometry [PMID: 19959397]/note:FunctionalCategory: conserved hypotheticals/note:binds to and represses fbpC [PMID: 19959397] chr1 CDS 2600731 2601879 . + . ID=CDS1;locus_tag=Rv2328;gene=PE23;product=PE family protein PE23;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642]/note:Contains IS6110 insertion site [PMID: 16725220] chr1 CDS 2601914 2603461 . - . ID=CDS1;locus_tag=Rv2329c;product=Probable nitrite extrusion protein 1 NarK1 (nitrite facilitator 1);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2603695 2604222 . - . ID=CDS1;locus_tag=Rv2330c;product=Probable lipoprotein LppP;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2604297 2604683 . + . ID=CDS1;locus_tag=Rv2331;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2604740 2605078 . + . ID=CDS1;locus_tag=Rv2331A;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.16.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2qtzA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.6.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bf4A,4dqkA,1ja0A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.14.14.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4dqkA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.14.13.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1tllA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0060192/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0032770/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0008941/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0005783/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,Ontology_term=0090346/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0009812/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0019899/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0090181/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0003958/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,Ontology_term=0009437/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0045880/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2qtzA,2bf4A,4dqkA,1ja0A,1tllA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qtzA,2bf4A,4dqkA,1ja0A,1tllA,Ontology_term=0071371/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0050661/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0071375/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0005789/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,Ontology_term=0032332/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0008202/note:identified by similarity of predicted tertiary structure to PDB 2bf4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,Ontology_term=0010181/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A,1tllA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,1tllA,Ontology_term=0045542/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0018393/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0004128/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 2bf4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,Ontology_term=0047726/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0007584/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0043066/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0046210/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bf4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,Ontology_term=0019395/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0071372/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2qtzA,2bf4A,4dqkA,1ja0A,1tllA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qtzA,2bf4A,4dqkA,1ja0A,1tllA,Ontology_term=0009055/note:identified by similarity of predicted tertiary structure to PDB 2bf4A,1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,1ja0A,Ontology_term=0070988/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0043231/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0043602/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0016126/note:identified by similarity of predicted tertiary structure to PDB 2bf4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,Ontology_term=0090031/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0042493/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0043154/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A,Ontology_term=0005741/note:identified by similarity of predicted tertiary structure to PDB 2bf4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,Ontology_term=0006694/note:identified by similarity of predicted tertiary structure to PDB 2bf4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,Ontology_term=0006696/note:identified by similarity of predicted tertiary structure to PDB 2bf4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bf4A,Ontology_term=0003420/note:identified by similarity of predicted tertiary structure to PDB 1ja0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ja0A chr1 CDS 2605108 2606754 . + . ID=CDS1;locus_tag=Rv2332;product=Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarboxylating)) (pyruvic-malic carboxylase) (NAD-me);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2606708 2608321 . - . ID=CDS1;locus_tag=Rv2333c;product=Integral membrane drug efflux protein Stp;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2608796 2609728 . + . ID=CDS1;locus_tag=Rv2334;product=Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2609732 2610421 . + . ID=CDS1;locus_tag=Rv2335;product=Probable serine acetyltransferase CysE (sat);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2610837 2611805 . + . ID=CDS1;locus_tag=Rv2336;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2611869 2612987 . - . ID=CDS1;locus_tag=Rv2337c;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2ymvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ymvA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2ymvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ymvA chr1 CDS 2613107 2613475 . - . ID=CDS1;locus_tag=Rv2338c;product=Possible molybdopterin biosynthesis protein MoeW;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2614714 2617581 . + . ID=CDS1;locus_tag=Rv2339;product=Probable conserved transmembrane transport protein MmpL9;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2617667 2618908 . - . ID=CDS1;locus_tag=Rv2340c;gene=PE_PGRS39;product=PE-PGRS family protein PE_PGRS39;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 2619597 2620016 . + . ID=CDS1;locus_tag=Rv2341;product=Probable conserved lipoprotein LppQ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2620272 2620529 . + . ID=CDS1;locus_tag=Rv2342;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2620533 2622452 . - . ID=CDS1;locus_tag=Rv2343c;product=Probable DNA primase DnaG;note=FunctionalCategory: information pathways chr1 CDS 2622457 2623752 . - . ID=CDS1;locus_tag=Rv2344c;product=Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2623821 2625803 . + . ID=CDS1;locus_tag=Rv2345;product=Probable phosphatase;Experiment=DESCRIPTION: Protein expression and purification, Immunoblotting, Circular dichroism spectroscopy, Phosphatase activity assay, ATPase activity assay. [PMID: 25782739]/note:FunctionalCategory: cell wall and cell processes/note:isolated domain shown to be capable of dephosphorylation of pNPP [PMID: 25782739];EC_number=3.1.3.- chr1 CDS 2625888 2626172 . - . ID=CDS1;locus_tag=Rv2346c;product=Putative ESAT-6 like protein EsxO (ESAT-6 like protein 6);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2626223 2626519 . - . ID=CDS1;locus_tag=Rv2347c;product=Putative ESAT-6 like protein EsxP (ESAT-6 like protein 7);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2626654 2626980 . - . ID=CDS1;locus_tag=Rv2348c;product=Hypothetical protein;note=FunctionalCategory: unknown;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:Possible antigen [PMID: 28387329] chr1 CDS 2627172 2628698 . - . ID=CDS1;locus_tag=Rv2349c;product=Probable phospholipase C 3 PlcC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2628781 2630319 . - . ID=CDS1;locus_tag=Rv2350c;product=Membrane-associated phospholipase C 2 PlcB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2630537 2632075 . - . ID=CDS1;locus_tag=Rv2351c;product=Membrane-associated phospholipase C 1 PlcA (MTP40 antigen);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2632923 2634098 . - . ID=CDS1;locus_tag=Rv2352c;gene=PPE38;product=PPE family protein PPE38;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642]/note:Found in whole-cell lysate but absent in culture filtrate and membrane [PMID: 21920479]/note:Located in the cell membrane [PMID: 21261938]/note:Associated with the cell wall and exposed on the cell surface in M. marinum, disruption of the gene altered the cell surface properties and led to deficiencies in cord formation, sliding motility, and biofilm formation (performed in M. marinum) [PMID: 22038915]/note:Decreases the amount of MHC class I proteins on the surface of macrophages infected with PPE38-expressing mycobacteria [PMID: 28348981]/note:Reduces levels of MHC class I transcripts [PMID: 28348981]/note:A decreased number of CD8+ T cells were found in spleen, liver, and lungs after infection of mice with M. smegmatis expressing PPE38 [PMID: 28348981] chr1 CDS 2634528 2635592 . - . ID=CDS1;locus_tag=Rv2353c;gene=PPE39;product=PPE family protein PPE39;Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938]/note:Located in the cell membrane [PMID: 21261938]/note:FunctionalCategory: PE/PPE chr1 CDS 2635628 2635954 . + . ID=CDS1;locus_tag=Rv2354;product=Probable transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2635903 2636889 . + . ID=CDS1;locus_tag=Rv2355;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2637688 2639535 . - . ID=CDS1;locus_tag=Rv2356c;gene=PPE40;product=PPE family protein PPE40;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:found in whole-cell lysate but absent in membrane and culture filtrate [PMID: 21920479]/note:down-regulated on treatment with glycine/lysozyme [PMID: 23195184] chr1 CDS 2639673 2641064 . - . ID=CDS1;locus_tag=Rv2357c;product=Probable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS);note=FunctionalCategory: information pathways chr1 CDS 2641246 2641653 . + . ID=CDS1;locus_tag=Rv2358;product=Probable transcriptional regulatory protein SmtB (probably ArsR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 2641650 2642042 . + . ID=CDS1;locus_tag=Rv2359;product=Probable zinc uptake regulation protein Zur;note=FunctionalCategory: regulatory proteins chr1 CDS 2642150 2642578 . - . ID=CDS1;locus_tag=Rv2360c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2642578 2643468 . - . ID=CDS1;locus_tag=Rv2361c;product=Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 2643461 2644258 . - . ID=CDS1;locus_tag=Rv2362c;product=Possible DNA repair protein RecO;note=FunctionalCategory: information pathways chr1 CDS 2644320 2645774 . + . ID=CDS1;locus_tag=Rv2363;product=Probable amidase AmiA2 (aminohydrolase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2645771 2646673 . - . ID=CDS1;locus_tag=Rv2364c;product=Probable GTP-binding protein Era;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2646747 2647088 . - . ID=CDS1;locus_tag=Rv2365c;product=putative cyclic amidine deaminase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.4.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2z3iA,3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,3b8fB,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,Ontology_term=0047711/note:identified by similarity of predicted tertiary structure to PDB 2z3iA,3oj6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z3iA,3oj6A,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 2fr6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fr6A,Ontology_term=0008251/note:identified by similarity of predicted tertiary structure to PDB 1wwrC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wwrC,Ontology_term=0009451/note:identified by similarity of predicted tertiary structure to PDB 2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,Ontology_term=0008703/note:identified by similarity of predicted tertiary structure to PDB 2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 2z3iA,3oj6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z3iA,3oj6A,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,2fr6A,1jtkA,1r5tA,Ontology_term=0001884/note:identified by similarity of predicted tertiary structure to PDB 1cttA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cttA,Ontology_term=0045980/note:identified by similarity of predicted tertiary structure to PDB 2fr6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fr6A,Ontology_term=0047844/note:identified by similarity of predicted tertiary structure to PDB 3ijfX,1cttA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ijfX,1cttA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1r5tA,Ontology_term=0002100/note:identified by similarity of predicted tertiary structure to PDB 1wwrC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wwrC,Ontology_term=0030308/note:identified by similarity of predicted tertiary structure to PDB 2fr6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fr6A,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1r5tA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,Ontology_term=0019239/note:identified by similarity of predicted tertiary structure to PDB 1wwrC,2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wwrC,2hxvA,Ontology_term=0001882/note:identified by similarity of predicted tertiary structure to PDB 2fr6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fr6A,Ontology_term=0043100/note:identified by similarity of predicted tertiary structure to PDB 3ijfX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ijfX,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2z3iA,3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z3iA,3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,2fr6A,1jtkA,1r5tA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1cttA,2fr6A,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cttA,2fr6A,1r5tA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 2fr6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fr6A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2z3iA,3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z3iA,3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,2fr6A,1jtkA,1r5tA,Ontology_term=0017001/note:identified by similarity of predicted tertiary structure to PDB 3b8fB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b8fB,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 1wwrC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wwrC,Ontology_term=0004126/note:identified by similarity of predicted tertiary structure to PDB 3dmoA,3ijfX,1cttA,4eg2A,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dmoA,3ijfX,1cttA,4eg2A,2fr6A,1jtkA,1r5tA,Ontology_term=0046109/note:identified by similarity of predicted tertiary structure to PDB 3ijfX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ijfX,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2z3iA,3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,3b8fB,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z3iA,3dmoA,3ijfX,1cttA,4eg2A,1wwrC,3oj6A,2hxvA,3b8fB,2fr6A,1jtkA,1r5tA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3ijfX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ijfX,Ontology_term=0015949/note:identified by similarity of predicted tertiary structure to PDB 1cttA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cttA,Ontology_term=0009231/note:identified by similarity of predicted tertiary structure to PDB 2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,Ontology_term=0008835/note:identified by similarity of predicted tertiary structure to PDB 2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2hxvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,Ontology_term=0008655/note:identified by similarity of predicted tertiary structure to PDB 4eg2A,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4eg2A,1r5tA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3ijfX,1cttA,4eg2A,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ijfX,1cttA,4eg2A,2fr6A,1jtkA,1r5tA,Ontology_term=0006216/note:identified by similarity of predicted tertiary structure to PDB 1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1r5tA,Ontology_term=0016814/note:identified by similarity of predicted tertiary structure to PDB 3b8fB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b8fB,Ontology_term=0009972/note:identified by similarity of predicted tertiary structure to PDB 3dmoA,3ijfX,1cttA,4eg2A,2fr6A,1jtkA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dmoA,3ijfX,1cttA,4eg2A,2fr6A,1jtkA,1r5tA,Ontology_term=0006217/note:identified by similarity of predicted tertiary structure to PDB 1cttA,1r5tA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cttA,1r5tA chr1 CDS 2647060 2648367 . - . ID=CDS1;locus_tag=Rv2366c;product=Probable conserved transmembrane protein/putative oxidoreductase;note=FunctionalCategory: cell wall and cell processes;EC_number=1.1.-.-;Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 4hg0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hg0A,Ontology_term=0016614/note:identified by similarity of predicted tertiary structure to PDB 4hg0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hg0A,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 4hg0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hg0A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4hg0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hg0A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 4hg0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hg0A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4hg0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hg0A chr1 CDS 2648364 2648912 . - . ID=CDS1;locus_tag=Rv2367c;product=putative metal-dependent endoribonuclease;Experiment=mass spectrometry [PMID: 27151218]/inference:similar to AA sequence:Perseus software, Uniprot, GO, statistical analysis [PMID: 27151218]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1xm5A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0016151/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0004222/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0031564/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0030490/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0042274/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0042254/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0016892/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0006412/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A,Ontology_term=0000478/note:identified by similarity of predicted tertiary structure to PDB 1xm5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xm5A chr1 CDS 2648916 2649974 . - . ID=CDS1;locus_tag=Rv2368c;product=Probable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2649946 2650248 . - . ID=CDS1;locus_tag=Rv2369c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2650245 2651558 . - . ID=CDS1;locus_tag=Rv2370c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2651753 2651938 . + . ID=CDS1;locus_tag=Rv2371;gene=PE_PGRS40;product=PE-PGRS family protein PE_PGRS40;note=FunctionalCategory: PE/PPE chr1 CDS 2652037 2652825 . - . ID=CDS1;locus_tag=Rv2372c;product=probable RsmE-like methyltransferase/ probable RsmE-like methyltransferase;Experiment=DESCRIPTION:recombinant DNA expression in vivo, protein crystallization [PMID: 24598751]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.193,EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1gz0F,1nxzA,1v6zA,2egvA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1gz0F/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 1gz0F,1nxzA,1v6zA,2egvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,1nxzA,1v6zA,2egvA,Ontology_term=0000453/note:identified by similarity of predicted tertiary structure to PDB 1gz0F/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1gz0F,1nxzA,1v6zA,2egvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,1nxzA,1v6zA,2egvA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1gz0F,1nxzA,1v6zA,2egvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,1nxzA,1v6zA,2egvA,Ontology_term=0070042/note:identified by similarity of predicted tertiary structure to PDB 1nxzA,2egvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nxzA,2egvA,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 1gz0F,1nxzA,1v6zA,2egvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,1nxzA,1v6zA,2egvA,Ontology_term=0070475/note:identified by similarity of predicted tertiary structure to PDB 1nxzA,2egvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nxzA,2egvA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1v6zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1v6zA,Ontology_term=0008173/note:identified by similarity of predicted tertiary structure to PDB 1gz0F/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 1gz0F,1nxzA,1v6zA,2egvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,1nxzA,1v6zA,2egvA,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 1v6zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1v6zA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 1v6zA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1v6zA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 1gz0F/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,Ontology_term=0070039/note:identified by similarity of predicted tertiary structure to PDB 1gz0F/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F,Ontology_term=0006396/note:identified by similarity of predicted tertiary structure to PDB 1gz0F/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gz0F chr1 CDS 2652839 2653987 . - . ID=CDS1;locus_tag=Rv2373c;product=Probable chaperone protein DnaJ2;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2654062 2655093 . - . ID=CDS1;locus_tag=Rv2374c;product=Probable heat shock protein transcriptional repressor HrcA;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2655265 2655582 . + . ID=CDS1;locus_tag=Rv2375;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2655609 2656115 . - . ID=CDS1;locus_tag=Rv2376c;gene=cfp2;product=Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2);note=FunctionalCategory: cell wall and cell processes, regulated by PhoP binding [PMID: 24874799], found in exosomes [PMID: 20662102] chr1 CDS 2656215 2656430 . - . ID=CDS1;locus_tag=Rv2377c;gene=mbtH;product=Putative conserved protein MbtH;Experiment=DESCRIPTION:NMR, CD spectroscopy [PMID: 20434955]/note:FunctionalCategory: lipid metabolism/note:predicted that MbtH-like proteins are integral components of nonribosomal peptide synthetases [PMID: 20845982] chr1 CDS 2656408 2657703 . - . ID=CDS1;locus_tag=Rv2378c;product=Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase);note=FunctionalCategory: lipid metabolism chr1 CDS 2657700 2662085 . - . ID=CDS1;locus_tag=Rv2379c;product=Peptide synthetase MbtF (peptide synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2662067 2667115 . - . ID=CDS1;locus_tag=Rv2380c;product=Peptide synthetase MbtE (peptide synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2667255 2670269 . - . ID=CDS1;locus_tag=Rv2381c;product=Polyketide synthetase MbtD (polyketide synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2670269 2671603 . - . ID=CDS1;locus_tag=Rv2382c;product=Polyketide synthetase MbtC (polyketide synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2671593 2675837 . - . ID=CDS1;locus_tag=Rv2383c;product=Phenyloxazoline synthase MbtB (phenyloxazoline synthetase);note=FunctionalCategory: lipid metabolism chr1 CDS 2675936 2677633 . + . ID=CDS1;locus_tag=Rv2384;product=Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase;note=FunctionalCategory: lipid metabolism chr1 CDS 2677729 2678649 . + . ID=CDS1;locus_tag=Rv2385;product=Putative acetyl hydrolase MbtJ;note=FunctionalCategory: lipid metabolism chr1 CDS 2678653 2680005 . - . ID=CDS1;locus_tag=Rv2386c;product=Isochorismate synthase MbtI;note=FunctionalCategory: lipid metabolism chr1 CDS 2680765 2682018 . + . ID=CDS1;locus_tag=Rv2387;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2682015 2683142 . - . ID=CDS1;locus_tag=Rv2388c;product=Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2683248 2683712 . - . ID=CDS1;locus_tag=Rv2389c;product=Probable resuscitation-promoting factor RpfD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2683709 2684266 . - . ID=CDS1;locus_tag=Rv2390c;product=Conserved hypothetical protein;Experiment=DESCRIPTION:Chloride measurement assay, microarray, in vitro fluorescence assays [PMID: 23592993]/note:FunctionalCategory: conserved hypotheticals/note:Gene expression induced by acidic pH and increase in concentration of Cl- [PMID: 23592993] chr1 CDS 2684679 2686370 . + . ID=CDS1;locus_tag=Rv2391;product=Ferredoxin-dependent sulfite reductase SirA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2686367 2687131 . + . ID=CDS1;locus_tag=Rv2392;product=Probable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase, thioredoxin DEP.) (padops reductase) (3'- phosphoadenylylsulfate reductase) (PAPS sulfotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2687128 2687973 . + . ID=CDS1;locus_tag=Rv2393;product=Ferrochelatase Che1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2688010 2689941 . + . ID=CDS1;locus_tag=Rv2394;product=Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2690072 2692075 . + . ID=CDS1;locus_tag=Rv2395;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2692224 2692439 . + . ID=CDS1;locus_tag=Rv2395A;product=Acid and phagosome regulated protein A AprA;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2692551 2692715 . + . ID=CDS1;locus_tag=Rv2395B;product=Acid and phagosome regulated protein B AprB;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2692799 2693884 . + . ID=CDS1;locus_tag=Rv2396;gene=PE_PGRS41;product=PE-PGRS family protein PE_PGRS41;note=FunctionalCategory: PE/PPE, pH regulated gene, induced by acidic pH of the phagosome [PMID: 21401735], When expressed in Mycobacterium smegmatis, survival is increased, host cell autophagy and apoptosis is inhibited, and TNF-α, IL-1β and IL-6 production is decreased [PMID: 28440335] chr1 CDS 2693909 2694964 . - . ID=CDS1;locus_tag=Rv2397c;product=Sulfate-transport ATP-binding protein ABC transporter CysA1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2694981 2695799 . - . ID=CDS1;locus_tag=Rv2398c;product=Probable sulfate-transport integral membrane protein ABC transporter CysW;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2695796 2696647 . - . ID=CDS1;locus_tag=Rv2399c;product=Probable sulfate-transport integral membrane protein ABC transporter CysT;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2696644 2697714 . - . ID=CDS1;locus_tag=Rv2400c;product=Probable sulfate-binding lipoprotein SubI;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2697728 2698057 . + . ID=CDS1;locus_tag=Rv2401;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2698042 2698245 . - . ID=CDS1;locus_tag=Rv2401A;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2698415 2700457 . + . ID=CDS1;locus_tag=Rv2402;product=Trehalase;Experiment=DESCRIPTION:Partial purification, enzyme activity assay [PMID: 17319935]/inference:similar to AA sequence:CLUSTALW [PMID: 17319935]/note:FunctionalCategory: conserved hypotheticals,Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:requires inorganic phosphate for enzyme activity [PMID: 17319935];EC_number=3.2.1.28 chr1 CDS 2700535 2701290 . - . ID=CDS1;locus_tag=Rv2403c;product=Probable conserved lipoprotein LppR;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2701287 2703248 . - . ID=CDS1;locus_tag=Rv2404c;product=Probable GTP-binding protein LepA (GTP-binding elongation factor);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2703269 2703838 . + . ID=CDS1;locus_tag=Rv2405;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in lipid metabolism based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2704009 2704437 . - . ID=CDS1;locus_tag=Rv2406c;product=Conserved protein/putative hydro-lyase/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3kh5A/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3pc2A,4uuuA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0030170/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0006535/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0004122/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0008652/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0019344/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A,Ontology_term=0019343/note:identified by similarity of predicted tertiary structure to PDB 3pc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pc2A chr1 CDS 2704697 2705518 . + . ID=CDS1;locus_tag=Rv2407;product=Type III sulfatase zinc-sulfatase;Experiment=DESCRIPTION:in vitro sulfatase activity assays, mass spectrometry [PMID: 23878250]/note:FunctionalCategory: conserved hypotheticals/note:Type III sulfatases are zinc dependent beta-lactamase;EC_number=3.1.6.- chr1 CDS 2706017 2706736 . + . ID=CDS1;locus_tag=Rv2408;gene=PE24;product=Possible PE family-related protein PE24;note=FunctionalCategory: PE/PPE chr1 CDS 2706494 2707333 . - . ID=CDS1;locus_tag=Rv2409c;product=putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3isrB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3isrB,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 3isrB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3isrB chr1 CDS 2707333 2708310 . - . ID=CDS1;locus_tag=Rv2410c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be a part of the proteasome based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2708310 2709965 . - . ID=CDS1;locus_tag=Rv2411c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be a part of the proteasome based on evidence from STRING database (protein-protein interactions)[PMID: 22485162], Predicted structural similarity to PDB:3n6xA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3n6xA chr1 CDS 2710075 2710335 . + . ID=CDS1;locus_tag=Rv2412;product=30S ribosomal protein S20 RpsT;note=FunctionalCategory: information pathways chr1 CDS 2710351 2711301 . - . ID=CDS1;locus_tag=Rv2413c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, modest structural similarity and strong AA identity to a potential glutathionylspermidine synthase, identified by similarity of predicted tertiary structure to PDB:1xxhA,3zh9B;Inference=ab initio prediction:I-TASSER:5.1;Ontology_term=0006260/note:identified by similarity of predicted tertiary structure to PDB 1xxhA,3zh9B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,3zh9B,Ontology_term=0006261/note:identified by similarity of predicted tertiary structure to PDB 1xxhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,Ontology_term=0009360/note:identified by similarity of predicted tertiary structure to PDB 1xxhA,3zh9B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,3zh9B,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1xxhA,3zh9B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,3zh9B,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 1xxhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1xxhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1xxhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,Ontology_term=0071897/note:identified by similarity of predicted tertiary structure to PDB 1xxhA,3zh9B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,3zh9B,Ontology_term=0003887/note:identified by similarity of predicted tertiary structure to PDB 1xxhA,3zh9B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xxhA,3zh9B chr1 CDS 2711332 2712876 . - . ID=CDS1;locus_tag=Rv2414c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2712891 2713784 . - . ID=CDS1;locus_tag=Rv2415c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2714124 2715332 . - . ID=CDS1;locus_tag=Rv2416c;product=Enhanced intracellular survival protein Eis, GCN5-related N-acetyltransferase;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2715472 2716314 . - . ID=CDS1;locus_tag=Rv2417c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2716395 2717138 . - . ID=CDS1;locus_tag=Rv2418c;gene=octT;product=probable acyltransferase (OctT);Experiment=DESCRIPTION:protein purification, in vitro recombinant gene expression, enzymatic activity assays, thin-layer chromatography, mass spectrometry, NMR [PMID: 26324178]/note:FunctionalCategory: conserved hypotheticals/note:appears to transfer octanoate to glucosylglycerate and diglucoglycerate [PMID: 26324178];EC_number=2.3.1.- chr1 CDS 2717128 2717799 . - . ID=CDS1;locus_tag=Rv2419c;product=Glucosyl-3-phosphoglycerate phosphatase GpgP;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2717796 2718176 . - . ID=CDS1;locus_tag=Rv2420c;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4wcwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wcwA,Ontology_term=0090071/note:identified by similarity of predicted tertiary structure to PDB 4wcwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wcwA,Ontology_term=0042256/note:identified by similarity of predicted tertiary structure to PDB 4wcwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wcwA,Ontology_term=0017148/note:identified by similarity of predicted tertiary structure to PDB 4wcwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wcwA,Ontology_term=0006417/note:identified by similarity of predicted tertiary structure to PDB 4wcwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wcwA,Ontology_term=0043023/note:identified by similarity of predicted tertiary structure to PDB 4wcwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wcwA chr1 CDS 2718173 2718808 . - . ID=CDS1;locus_tag=Rv2421c;product=Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2719083 2719355 . + . ID=CDS1;locus_tag=Rv2422;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2719597 2720643 . + . ID=CDS1;locus_tag=Rv2423;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2720776 2721777 . - . ID=CDS1;locus_tag=Rv2424c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2721866 2723308 . - . ID=CDS1;locus_tag=Rv2425c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2723308 2724183 . - . ID=CDS1;locus_tag=Rv2426c;product=putative ATPase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.6.1.-;Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 5c3cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c3cA,Ontology_term=0016887/note:identified by similarity of predicted tertiary structure to PDB 5c3cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c3cA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 5c3cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c3cA chr1 CDS 2724230 2725477 . - . ID=CDS1;locus_tag=Rv2427c;product=Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2725571 2726087 . - . ID=CDS1;locus_tag=Rv2427A;product=Transcriptional regulator OxyR', pseudogene;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2726193 2726780 . + . ID=CDS1;locus_tag=Rv2428;product=Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2726806 2727339 . + . ID=CDS1;locus_tag=Rv2429;product=Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2727336 2727920 . - . ID=CDS1;locus_tag=Rv2430c;gene=PPE41;product=Probable Immunodominant B-cell antigen/PPE family protein PPE41;Experiment=DESCRIPTION: RT-PCR, Protein expression and purification, ELISA [PMID: 14573653],Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479],Experiment=EXISTENCE:2-D gel electrophoresis, liquid chromatography mass spectrometry [PMID: 17443846]/note:FunctionalCategory: PE/PPE/note:Induces a strong B-cell response in infected subjects [PMID: 14573653]/note:Lacks a transmembrane domain, hence, not a membrane bound protein [PMID: 14573653]/note:Consists predominantly of alpha helical proteins [PMID: 15249047]/note:Co-transcribed with Rv2431c(PE25) and forms a heterodimer with PE25, PE41 and PE25 interact with and solubilize each other only when co-expressed [PMID: 16458305]/note:Probably secreted, found expressed in the culture filtrate [PMID: 17443846] [PMID: 21920479]/note:Found in whole-cell lysate but absent in the membrane fraction [PMID: 21920479] chr1 CDS 2727967 2728266 . - . ID=CDS1;locus_tag=Rv2431c;gene=PE25;product=PE family protein PE25;Experiment=DESCRIPTION:Protein expression and purification, MTT assay in macrophages, ELISA, TUNEL assay, flow cytometry, LDH assay [PMID: 25379378],Experiment=EXISTENCE:Label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:2-dimensional gel electrophoresis, liquid chromatography mass spectrometry [PMID: 17443846],Experiment=EXISTENCE:Gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479],Experiment=EXISTENCE:SDS-PAGE, gel electrophoresis, multi-dimensional liquid chromatography and mass spectrometry [PMID: 20825248]/note:FunctionalCategory: PE/PPE/note:Co-transcribed with Rv2430c(PPE41) and forms a dimer [PMID: 16690741]/note:PE25/PPE41 complex induces necrosis, but not apoptosis, in macrophages and drives TNF-alpha production in macrophages [PMID: 25379378]/note:PE25 is insoluble when expressed on its own but as a dimer with PPE41, it is soluble [PMID: 16690741]/note:PE25/PPE41 complex increases expression of CD80, CD86, and MHC class II markers in dendritic cells [PMID: 26318856]/note:Stimulates proliferation of dendritic cells [PMID: 16690741,26318856]/note:Induces strong humoral response [PMID: 26318856]/note:Probably secreted, found expressed in the culture filtrate [PMID: 17443846,21920479]/note:Found in the cell membrane and whole cell lysate [PMID: 21261938,21920479]/note:Found in the cell wall [PMID: 20825248] chr1 CDS 2728437 2728847 . - . ID=CDS1;locus_tag=Rv2432c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2728844 2729134 . - . ID=CDS1;locus_tag=Rv2433c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2729115 2730560 . - . ID=CDS1;locus_tag=Rv2434c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, cNMP-binding protein [PMID: 10673278] chr1 CDS 2730557 2732749 . - . ID=CDS1;locus_tag=Rv2435c;product=Probable cyclase (adenylyl- or guanylyl-)(adenylate- or guanylate-);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2733230 2734144 . + . ID=CDS1;locus_tag=Rv2436;product=Ribokinase RbsK;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2734376 2734795 . + . ID=CDS1;locus_tag=Rv2437;product=Conserved transmembrane protein/putative methyltransferase;note=FunctionalCategory: cell wall and cell processes;EC_number=2.1.1.-;Ontology_term=0006481/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB,Ontology_term=0004671/note:identified by similarity of predicted tertiary structure to PDB 4a2nB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4a2nB chr1 CDS 2734792 2736831 . - . ID=CDS1;locus_tag=Rv2438c;product=Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2736709 2736987 . + . ID=CDS1;locus_tag=Rv2438A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2737117 2738247 . - . ID=CDS1;locus_tag=Rv2439c;product=Probable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2738247 2739686 . - . ID=CDS1;locus_tag=Rv2440c;product=Probable GTP1/Obg-family GTP-binding protein Obg;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2739772 2740032 . - . ID=CDS1;locus_tag=Rv2441c;product=50S ribosomal protein L27 RpmA;note=FunctionalCategory: information pathways chr1 CDS 2740047 2740361 . - . ID=CDS1;locus_tag=Rv2442c;product=50S ribosomal protein L21 RplU;note=FunctionalCategory: information pathways chr1 CDS 2740709 2742184 . + . ID=CDS1;locus_tag=Rv2443;product=Probable C4-dicarboxylate-transport transmembrane protein DctA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2742123 2744984 . - . ID=CDS1;locus_tag=Rv2444c;product=Possible ribonuclease E Rne;note=FunctionalCategory: information pathways chr1 CDS 2745314 2745724 . - . ID=CDS1;locus_tag=Rv2445c;product=Probable nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleoside-2-P kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2745767 2746138 . - . ID=CDS1;locus_tag=Rv2446c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2746135 2747598 . - . ID=CDS1;locus_tag=Rv2447c;product=Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2747595 2750255 . - . ID=CDS1;locus_tag=Rv2448c;product=Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2750313 2751572 . - . ID=CDS1;locus_tag=Rv2449c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2751662 2752180 . - . ID=CDS1;locus_tag=Rv2450c;product=Probable resuscitation-promoting factor RpfE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2752262 2752660 . + . ID=CDS1;locus_tag=Rv2451;product=Hypothetical proline and serine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2752848 2752994 . - . ID=CDS1;locus_tag=Rv2452c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2753018 2753623 . - . ID=CDS1;locus_tag=Rv2453c;product=Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2753625 2754746 . - . ID=CDS1;locus_tag=Rv2454c;product=Probable oxidoreductase (beta subunit);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2754743 2756704 . - . ID=CDS1;locus_tag=Rv2455c;product=Probable oxidoreductase (alpha subunit);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2756936 2758192 . - . ID=CDS1;locus_tag=Rv2456c;product=Probable conserved integral membrane transport protein/Putative transport protein;note=FunctionalCategory: cell wall and cell processes, potential carbohydrate transporter, identified by similarity of predicted tertiary structure to PDB 5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5c65A, 4gbyA, 4ybqA, 3o7pA, 5aymA, 4zowA, 4pypA, 4j05A, 4w6vA , 4apsA , 4ikvA, 4iu8A, 1pw4A, 4lepA, 2xutA chr1 CDS 2758208 2759488 . - . ID=CDS1;locus_tag=Rv2457c;product=Probable ATP-dependent CLP protease ATP-binding subunit ClpX;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2759779 2760687 . + . ID=CDS1;locus_tag=Rv2458;product=Probable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (cysteine methyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2760854 2762380 . + . ID=CDS1;locus_tag=Rv2459;gene=jefA;product=Probable drug efflux pump.;Experiment=DESCRIPTION: Gene amplification, Transformation in E. coli, Electroporation in M. tuberculosis, RNA isolation, Real-time RT-PCR,MIC determination by Resazurin microtitre assay. [PMID: 20716818]/note:FunctionalCategory: cell wall and cell processes/note:induced by isoniazid, streptomycin, ethambutol [PMID: 20001742]/note:induced in an ofloxacin monoresistant strain when the strain is exposed to ofloxacin [PMID: 28496433] chr1 CDS 2762531 2763175 . - . ID=CDS1;locus_tag=Rv2460c;product=Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2763172 2763774 . - . ID=CDS1;locus_tag=Rv2461c;product=Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2763891 2765291 . - . ID=CDS1;locus_tag=Rv2462c;product=Probable trigger factor (TF) protein Tig;Experiment=2D gel electrophoresis, SDS PAGE, MALDI-TOF MS, MS/MS [PMID: 26436944]/inference:similar to AA sequence:BLASTP [PMID: 26436944]/inference:protein motif:InterProScan, KEGG, GPS-PUP [PMID: 26436944]/note:FunctionalCategory: cell wall and cell processes/note:putatively acts a a chaperone in protein export [PMID: 26436944],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:over expressed in amikacin and kanamycin resistant isolates [PMID: 27895634];EC_number=5.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3gtyX/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006457/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0007049/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0000413/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0003755/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0051301/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX,Ontology_term=0015031/note:identified by similarity of predicted tertiary structure to PDB 3gtyX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gtyX chr1 CDS 2765655 2766839 . + . ID=CDS1;locus_tag=Rv2463;product=Probable esterase/lipase LipP;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2766859 2767665 . - . ID=CDS1;locus_tag=Rv2464c;product=Possible DNA glycosylase;note=FunctionalCategory: information pathways chr1 CDS 2767671 2768159 . - . ID=CDS1;locus_tag=Rv2465c;product=Ribose-5-phosphate isomerase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2768261 2768884 . - . ID=CDS1;locus_tag=Rv2466c;product=thioredoxin-like protein;Experiment=DESCRIPTION:in vitro gene expression and overexpression, X-ray crystallography [PMID: 24877756]/note:FunctionalCategory: conserved hypotheticals/note:reduced form of the protein predicted to activate pro-drug TP053 (through reduction of the NO2 group) [PMID: 24877756] chr1 CDS 2768986 2771571 . + . ID=CDS1;locus_tag=Rv2467;product=Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2771644 2772147 . - . ID=CDS1;locus_tag=Rv2468c;product=conserved protein;Experiment=DESCRIPTION:in vitro recombinant DNA expression, protein purification, western blot, T-cell stimulation and proliferation assay [PMID: 22158781]/note:FunctionalCategory: conserved hypotheticals/note:shown to co-stimulate human CD4+ T cells through VLA-5 chr1 CDS 2772098 2772331 . - . ID=CDS1;locus_tag=Rv2468A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2772367 2773035 . - . ID=CDS1;locus_tag=Rv2469c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2773178 2773564 . + . ID=CDS1;locus_tag=Rv2470;product=Globin (oxygen-binding protein) GlbO;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2773564 2775204 . + . ID=CDS1;locus_tag=Rv2471;product=Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidase) (acid maltase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2775272 2775565 . + . ID=CDS1;locus_tag=Rv2472;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2775568 2776284 . + . ID=CDS1;locus_tag=Rv2473;product=Possible alanine and proline rich membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2776316 2776969 . - . ID=CDS1;locus_tag=Rv2474c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2776975 2777391 . - . ID=CDS1;locus_tag=Rv2475c;product=Conserved protein/putative thioester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2oiwC,1lo8A,2cyeC,4k00A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1lo8A,4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lo8A,4k00A,Ontology_term=0042372/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,Ontology_term=0016290/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,Ontology_term=0018739/note:identified by similarity of predicted tertiary structure to PDB 1lo8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lo8A,Ontology_term=0004778/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,Ontology_term=0047617/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A,Ontology_term=0016790/note:identified by similarity of predicted tertiary structure to PDB 4k00A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4k00A chr1 CDS 2777388 2782262 . - . ID=CDS1;locus_tag=Rv2476c;product=Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2782366 2784042 . - . ID=CDS1;locus_tag=Rv2477c;product=Probable macrolide-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2784123 2784608 . - . ID=CDS1;locus_tag=Rv2478c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in DNA recombination (DOI:10.1016/j.tube.2016.04.011) chr1 CDS 2784657 2785643 . - . ID=CDS1;locus_tag=Rv2479c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2785592 2785918 . - . ID=CDS1;locus_tag=Rv2480c;product=Possible transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2786575 2786898 . - . ID=CDS1;locus_tag=Rv2481c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2786914 2789283 . - . ID=CDS1;locus_tag=Rv2482c;product=Probable glycerol-3-phosphate acyltransferase PlsB2 (GPAT);note=FunctionalCategory: lipid metabolism chr1 CDS 2789280 2791022 . - . ID=CDS1;locus_tag=Rv2483c;product=Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoserine phosphohydrolase) (PSP) (pspase) + 1-acyl-SN-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid acyltransferase) (LPAAT);note=FunctionalCategory: lipid metabolism chr1 CDS 2791019 2792494 . - . ID=CDS1;locus_tag=Rv2484c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 2792723 2793988 . - . ID=CDS1;locus_tag=Rv2485c;product=Probable carboxylesterase LipQ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2794350 2795120 . + . ID=CDS1;locus_tag=Rv2486;product=Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 2795301 2797385 . - . ID=CDS1;locus_tag=Rv2487c;gene=PE_PGRS42;product=Probable CD8 antigen/PE-PGRS family protein PE_PGRS42;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642],Experiment=DESCRIPTION:Preparation of Mtb affected dendritic cells, interferon-gamma ELISPOT assay, determination of ex vivo T-cell frequency [PMID: 23805289]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 2797467 2800880 . - . ID=CDS1;locus_tag=Rv2488c;product=Probable transcriptional regulatory protein (LuxR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 2800846 2801145 . - . ID=CDS1;locus_tag=Rv2489c;product=Hypothetical alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2801254 2806236 . - . ID=CDS1;locus_tag=Rv2490c;gene=PE_PGRS43;product=PE-PGRS family protein PE_PGRS43;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642]/note:Immunization of mice with Rv2490c (possible vaccine candidate) reduced lung CFU counts [PMID: 26245027] chr1 CDS 2806665 2807288 . + . ID=CDS1;locus_tag=Rv2491;product=putative N-glycosyl compound hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.2.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2q4dA,2q4oA,5itsA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0009691/note:identified by similarity of predicted tertiary structure to PDB 2q4dA,2q4oA,5itsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA,2q4oA,5itsA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2q4dA,2q4oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA,2q4oA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2q4dA,2q4oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA,2q4oA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2q4dA,2q4oA,5itsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA,2q4oA,5itsA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2q4dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4dA chr1 CDS 2807278 2808030 . + . ID=CDS1;locus_tag=Rv2492;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2808083 2808304 . + . ID=CDS1;locus_tag=Rv2493;product=Possible antitoxin VapB38;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2808310 2808735 . + . ID=CDS1;locus_tag=Rv2494;product=Possible toxin VapC38. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2808758 2809939 . - . ID=CDS1;locus_tag=Rv2495c;product=Probable branched-chain keto acid dehydrogenase E2 component BkdC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2809936 2810982 . - . ID=CDS1;locus_tag=Rv2496c;product=Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2810993 2812096 . - . ID=CDS1;locus_tag=Rv2497c;product=Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2812355 2813176 . - . ID=CDS1;locus_tag=Rv2498c;product=Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2813173 2813730 . - . ID=CDS1;locus_tag=Rv2499c;product=Possible oxidase regulatory-related protein/putative hydro-lyase;Experiment=DESCRIPTION:protein expression and purification, crystallization of Rv0216 and structural comparison with Rv2499c using PDB, enoyl-CoA hydratase activity assay (using 2-butenoyl CoA as substrate) [PMID: 15987908]/note:FunctionalCategory: intermediary metabolism and respiration/note:contains single hotdog domain (SHD) and protein is structurally similar to Rv0216 [PMID: 15987908]/note:protein does not show hydratase activity for the substrate used in the study (alternate substrate proposed as SHD hydratases are known to show a variation in substrate specificity due to differences in structure of active site) [PMID: 15987908];EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1iq6B,2c2iA,5cpgA,1s9cG,4rljA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006633/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,2c2iA,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,2c2iA,5cpgA,Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,2c2iA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA,Ontology_term=0005835/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,5cpgA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,2c2iA,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,2c2iA,5cpgA,Ontology_term=0004300/note:identified by similarity of predicted tertiary structure to PDB 2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c2iA,Ontology_term=0018812/note:identified by similarity of predicted tertiary structure to PDB 2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c2iA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,2c2iA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,5cpgA,Ontology_term=0004312/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,5cpgA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2c2iA,4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c2iA,4rljA,Ontology_term=0019171/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA chr1 CDS 2813727 2814911 . - . ID=CDS1;locus_tag=Rv2500c;product=Possible acyl-CoA dehydrogenase FadE19 (MMGC);note=FunctionalCategory: lipid metabolism chr1 CDS 2814916 2816880 . - . ID=CDS1;locus_tag=Rv2501c;product=Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP);note=FunctionalCategory: lipid metabolism chr1 CDS 2816885 2818474 . - . ID=CDS1;locus_tag=Rv2502c;product=Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1;note=FunctionalCategory: lipid metabolism chr1 CDS 2818471 2819127 . - . ID=CDS1;locus_tag=Rv2503c;product=Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase);note=FunctionalCategory: lipid metabolism chr1 CDS 2819124 2819870 . - . ID=CDS1;locus_tag=Rv2504c;product=Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha subunit) ScoA (3-oxo acid:CoA transferase) (OXCT A) (succinyl-CoA:3-oxoacid-coenzyme A transferase);note=FunctionalCategory: lipid metabolism chr1 CDS 2819953 2821596 . - . ID=CDS1;locus_tag=Rv2505c;product=Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2821712 2822359 . + . ID=CDS1;locus_tag=Rv2506;product=Probable transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2822438 2823259 . + . ID=CDS1;locus_tag=Rv2507;product=Possible conserved proline rich membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2823256 2824593 . - . ID=CDS1;locus_tag=Rv2508c;product=Probable conserved integral membrane leucine and alanine rich protein/putative MFS membrane transporter;note=FunctionalCategory: cell wall and cell processes, identified by similarity of predicted tertiary structure to PDB 3wdoA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3wdoA chr1 CDS 2824678 2825484 . + . ID=CDS1;locus_tag=Rv2509;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2825488 2827089 . - . ID=CDS1;locus_tag=Rv2510c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2827157 2827804 . + . ID=CDS1;locus_tag=Rv2511;product=Oligoribonuclease Orn;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2828556 2829803 . - . ID=CDS1;locus_tag=Rv2512c;product=Transposase for insertion sequence element IS1081;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2830161 2830583 . + . ID=CDS1;locus_tag=Rv2513;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2830877 2831338 . - . ID=CDS1;locus_tag=Rv2514c;product=putative ester hydrolase;note=FunctionalCategory: conserved hypotheticals, Predicted to be regulated by general enzymatic activity based on evidence from STRING database (protein-protein interactions)[PMID: 22485162];EC_number=3.1.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3tndA,5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0045926/note:identified by similarity of predicted tertiary structure to PDB 5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,4xgqA,Ontology_term=0090305/note:identified by similarity of predicted tertiary structure to PDB 3tndA,5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA,5sv2A,4xgqA,Ontology_term=0040008/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A,Ontology_term=0004540/note:identified by similarity of predicted tertiary structure to PDB 3tndA,5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA,5sv2A,4xgqA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3tndA,5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA,5sv2A,4xgqA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3tndA,5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA,5sv2A,4xgqA,Ontology_term=0090501/note:identified by similarity of predicted tertiary structure to PDB 3tndA,5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA,5sv2A,4xgqA,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 3tndA,5sv2A,4xgqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA,5sv2A,4xgqA,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 3tndA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA chr1 CDS 2831344 2832591 . - . ID=CDS1;locus_tag=Rv2515c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2832710 2833513 . - . ID=CDS1;locus_tag=Rv2516c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2833510 2833761 . - . ID=CDS1;locus_tag=Rv2517c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2834109 2835335 . - . ID=CDS1;locus_tag=Rv2518c;product=Probable L,D-transpeptidase LdtB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2835785 2837263 . + . ID=CDS1;locus_tag=Rv2519;gene=PE26;product=PE family protein PE26;note=FunctionalCategory: PE/PPE, Regulated by sigE during macrophage infection [PMID: 18657035], contains domain similar to aspartic protease domain [PMID: 23923105] chr1 CDS 2837388 2837612 . - . ID=CDS1;locus_tag=Rv2520c;product=Possible conserved membrane protein;Experiment=DESCRIPTION:mbRT-PCR [PMID: 12010964]/note:FunctionalCategory: cell wall and cell processes/note:upregulated during growth in human monocyte THP-1 cells [PMID: 12010964],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2837684 2838157 . + . ID=CDS1;locus_tag=Rv2521;product=Probable bacterioferritin comigratory protein Bcp;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2838129 2839541 . - . ID=CDS1;locus_tag=Rv2522c;product=putative metallopeptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.13.-,EC_number=3.4.17.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,3dljA,Ontology_term=0103046/note:identified by similarity of predicted tertiary structure to PDB 2zofA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,Ontology_term=0032268/note:identified by similarity of predicted tertiary structure to PDB 3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dljA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 2zofA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2zofA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,3dljA,Ontology_term=0004180/note:identified by similarity of predicted tertiary structure to PDB 2zofA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,3dljA,Ontology_term=0016805/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,3dljA,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 2zofA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dljA,Ontology_term=0008242/note:identified by similarity of predicted tertiary structure to PDB 4g1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4g1pA,Ontology_term=0070573/note:identified by similarity of predicted tertiary structure to PDB 4g1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4g1pA,Ontology_term=0102008/note:identified by similarity of predicted tertiary structure to PDB 2zofA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,Ontology_term=0006751/note:identified by similarity of predicted tertiary structure to PDB 4g1pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4g1pA,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,3dljA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,3dljA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,3dljA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,3dljA,Ontology_term=0008237/note:identified by similarity of predicted tertiary structure to PDB 2zofA,4g1pA,3dljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zofA,4g1pA,3dljA chr1 CDS 2839538 2839930 . - . ID=CDS1;locus_tag=Rv2523c;product=holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 2840123 2849332 . - . ID=CDS1;locus_tag=Rv2524c;product=Probable fatty acid synthase Fas (fatty acid synthetase);note=FunctionalCategory: lipid metabolism chr1 CDS 2849852 2850574 . - . ID=CDS1;locus_tag=Rv2525c;product=probable peptidoglycan hydrolase;Experiment=DESCRIPTION:in vitro recombinant DNA expression, gene knockout, southern analysis, protein chip analysis, whole-cell radiolabelling [PMID: 16952959],Experiment=DESCRIPTION:in vitro recombinant DNA expression and protein purification, mass spectrometry analysis, enzyme activity analysis [PMID: 25869294],Experiment=DESCRIPTION:in vitro recombinant DNA expression and protein purification, crystallization [PMID: 25260828]/inference:ab initio prediction:molecular docking studies using CHARMM force field implemented in DiscoveryStudio [PMID: 25260828]/note:FunctionalCategory: conserved hypotheticals/note:Secreted, predicted to be a substrate of the twin arginine translocation (tat) export system./note:involved in cell envelope biogenesis;EC_number=3.2.1.17 chr1 CDS 2851091 2851318 . + . ID=CDS1;locus_tag=Rv2526;product=Possible antitoxin VapB17;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2851315 2851716 . + . ID=CDS1;locus_tag=Rv2527;product=Possible toxin VapC17;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2851751 2852671 . - . ID=CDS1;locus_tag=Rv2528c;product=Probable restriction system protein Mrr;note=FunctionalCategory: information pathways chr1 CDS 2853316 2854266 . + . ID=CDS1;locus_tag=Rv2529;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:structurally similar to coatamer proteins of mice that mediate biosynthetic transport from the endoplasmic reticulum/note:possibly involved in host-pathogen interation/note:this protein is structurally similar to a different subunit of the coatamer than that which Rv2308 is similar to./note:identified by similarity of predicted tertiary structure to PDB 5a1uE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a1uE chr1 CDS 2854267 2854686 . - . ID=CDS1;locus_tag=Rv2530c;product=Possible toxin VapC39. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2854683 2854907 . - . ID=CDS1;locus_tag=Rv2530A;product=Possible antitoxin VapB39;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2854938 2857781 . - . ID=CDS1;locus_tag=Rv2531c;product=Probable amino acid decarboxylase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2857853 2858254 . - . ID=CDS1;locus_tag=Rv2532c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2858254 2858724 . - . ID=CDS1;locus_tag=Rv2533c;product=N utilization substance protein NusB (NusB protein);note=FunctionalCategory: information pathways chr1 CDS 2858727 2859290 . - . ID=CDS1;locus_tag=Rv2534c;product=Probable elongation factor P Efp;note=FunctionalCategory: information pathways chr1 CDS 2859300 2860418 . - . ID=CDS1;locus_tag=Rv2535c;product=Probable cytoplasmic peptidase PepQ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2860452 2861144 . + . ID=CDS1;locus_tag=Rv2536;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, induced and exported in vivo [PMID: 28442606] chr1 CDS 2861148 2861591 . - . ID=CDS1;locus_tag=Rv2537c;product=3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2861588 2862676 . - . ID=CDS1;locus_tag=Rv2538c;product=3-dehydroquinate synthase AroB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2862673 2863203 . - . ID=CDS1;locus_tag=Rv2539c;product=Shikimate kinase AroK (SK);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2863207 2864412 . - . ID=CDS1;locus_tag=Rv2540c;product=Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2864427 2864834 . + . ID=CDS1;locus_tag=Rv2541;product=Hypothetical alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2865130 2866341 . + . ID=CDS1;locus_tag=Rv2542;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2866468 2867127 . + . ID=CDS1;locus_tag=Rv2543;product=Probable conserved lipoprotein LppA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2867124 2867786 . + . ID=CDS1;locus_tag=Rv2544;product=Probable conserved lipoprotein LppB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2867783 2868061 . + . ID=CDS1;locus_tag=Rv2545;product=Possible antitoxin VapB18;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2868154 2868567 . + . ID=CDS1;locus_tag=Rv2546;product=Possible toxin VapC18;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2868606 2868863 . + . ID=CDS1;locus_tag=Rv2547;product=Possible antitoxin VapB19;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2868860 2869237 . + . ID=CDS1;locus_tag=Rv2548;product=Possible toxin VapC19;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2869253 2869627 . - . ID=CDS1;locus_tag=Rv2548A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2869727 2870122 . - . ID=CDS1;locus_tag=Rv2549c;product=Possible toxin VapC20;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2870119 2870364 . - . ID=CDS1;locus_tag=Rv2550c;product=Possible antitoxin VapB20;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2870775 2871194 . - . ID=CDS1;locus_tag=Rv2551c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2871206 2872015 . - . ID=CDS1;locus_tag=Rv2552c;product=Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2872012 2873265 . - . ID=CDS1;locus_tag=Rv2553c;product=Probable conserved membrane protein/ putative lyase;note=FunctionalCategory: cell wall and cell processes;EC_number=4.-.-.-;Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 4iiwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iiwA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4iiwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iiwA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 4iiwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iiwA,Ontology_term=0005887/note:identified by similarity of predicted tertiary structure to PDB 4iiwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iiwA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 4iiwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iiwA,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4iiwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iiwA chr1 CDS 2873258 2873770 . - . ID=CDS1;locus_tag=Rv2554c;gene=ruvX;product=Probable Holliday junction (HJ) resolvase (RuvX);Experiment=DESCRIPTION:Recombinant DNA expression and protein purification, DNA binding assays, endonuclease activity assays [PMID: 27345943]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.22.4 chr1 CDS 2873771 2876485 . - . ID=CDS1;locus_tag=Rv2555c;product=Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS);note=FunctionalCategory: information pathways chr1 CDS 2876576 2876965 . - . ID=CDS1;locus_tag=Rv2556c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2877072 2877746 . + . ID=CDS1;locus_tag=Rv2557;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2877831 2878541 . + . ID=CDS1;locus_tag=Rv2558;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2878571 2879929 . - . ID=CDS1;locus_tag=Rv2559c;product=Conserved hypothetical alanine leucine valine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2880075 2881052 . + . ID=CDS1;locus_tag=Rv2560;product=Probable proline and glycine rich transmembrane protein;Experiment=MADL-TOF MS, analytical reverse phase HPLC, radiolabelling, binding assay, saturation assay, Analogue peptide competition binding assay, cross-linking assays, invasion ihibition assay with HABPs, flow cytometry [PMID: 18005255]/inference:similar to AA sequence:BLASTP [PMID: 18005255]/inference:alignment:ClustalW [PMID: 18005255]/inference:ab initio prediction: PROTPARAM, TMHMM, TMPRED, PSORT [PMID: 18005255]/note:FunctionalCategory: cell wall and cell processes/note:involved in the invasion process of monocytes and epithelial cells [PMID: 18005255] chr1 CDS 2881409 2881702 . + . ID=CDS1;locus_tag=Rv2561;product=putative phosphorus-oxygen lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3uvjA,1culA,2w01A,1culB,2wz1A,4wp3A,1azsA,1ybtB,1y11A,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0004016/note:identified by similarity of predicted tertiary structure to PDB 4wp3A,1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,1y11A,Ontology_term=0007165/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0035556/note:identified by similarity of predicted tertiary structure to PDB 3uvjA,1culA,2w01A,1culB,2wz1A,4wp3A,1azsA,1ybtB,1y11A,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uvjA,1culA,2w01A,1culB,2wz1A,4wp3A,1azsA,1ybtB,1y11A,1wc4A,1fx2A,4clfA,Ontology_term=0030818/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 4wp3A,1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,1y11A,Ontology_term=0016849/note:identified by similarity of predicted tertiary structure to PDB 3uvjA,1culA,2w01A,1culB,2wz1A,4wp3A,1azsA,1ybtB,1y11A,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uvjA,1culA,2w01A,1culB,2wz1A,4wp3A,1azsA,1ybtB,1y11A,1wc4A,1fx2A,4clfA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4wp3A,1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,1y11A,Ontology_term=0006171/note:identified by similarity of predicted tertiary structure to PDB 4wp3A,1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,1y11A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0008289/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009268/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A,Ontology_term=0009190/note:identified by similarity of predicted tertiary structure to PDB 3uvjA,1culA,2w01A,1culB,2wz1A,4wp3A,1azsA,1ybtB,1y11A,1wc4A,1fx2A,4clfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uvjA,1culA,2w01A,1culB,2wz1A,4wp3A,1azsA,1ybtB,1y11A,1wc4A,1fx2A,4clfA,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 4wp3A,1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wp3A,1y11A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1y11A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y11A chr1 CDS 2881758 2882147 . + . ID=CDS1;locus_tag=Rv2562;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2882290 2883339 . + . ID=CDS1;locus_tag=Rv2563;product=Probable glutamine-transport transmembrane protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2883342 2884334 . + . ID=CDS1;locus_tag=Rv2564;product=Probable glutamine-transport ATP-binding protein ABC transporter GlnQ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2884611 2886362 . + . ID=CDS1;locus_tag=Rv2565;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2886373 2889795 . + . ID=CDS1;locus_tag=Rv2566;product=long conserved protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be a part of the proteasome based on evidence from STRING database (protein-protein interactions)[PMID: 22485162], structurally similar to venom prothrombin activator pseutarin-C non-catalytic subunit, possibly involved in influencing host coagulation, identified by similarity of predicted tertiary structure to PDB 4bxsV;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bxsV chr1 CDS 2889795 2892449 . + . ID=CDS1;locus_tag=Rv2567;product=Conserved hypothetical alanine and leucine rich protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be a part of the proteasome based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2892446 2893471 . - . ID=CDS1;locus_tag=Rv2568c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2893464 2894408 . - . ID=CDS1;locus_tag=Rv2569c;product=putative hydrolase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.-.-.-;Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3isrB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3isrB,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 3isrB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3isrB chr1 CDS 2894512 2894901 . + . ID=CDS1;locus_tag=Rv2570;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2894893 2895960 . - . ID=CDS1;locus_tag=Rv2571c;product=Probable transmembrane alanine and valine and leucine rich protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2896013 2897803 . - . ID=CDS1;locus_tag=Rv2572c;product=Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase);note=FunctionalCategory: information pathways chr1 CDS 2898043 2898783 . + . ID=CDS1;locus_tag=Rv2573;product=Probable 2-dehydropantoate 2-reductase;note=FunctionalCategory: conserved hypotheticals, possibly mediates the conversion of 2-dehydropantoate to (R)-pantoate (PanE) [PMID: 27676316], possible involvement in pantanoate biosynthesis pathway [PMID: 27676316];EC_number=1.1.1.169 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3ghyA,4ol9A,3hn2A,3hwrA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3ghyA,4ol9A,3hn2A,3hwrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ghyA,4ol9A,3hn2A,3hwrA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4ol9A,3hn2A,3hwrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ol9A,3hn2A,3hwrA,Ontology_term=0050661/note:identified by similarity of predicted tertiary structure to PDB 3ghyA,4ol9A,3hn2A,3hwrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ghyA,4ol9A,3hn2A,3hwrA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3hwrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hwrA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3ghyA,4ol9A,3hn2A,3hwrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ghyA,4ol9A,3hn2A,3hwrA,Ontology_term=0033317/note:identified by similarity of predicted tertiary structure to PDB 4ol9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ol9A,Ontology_term=0015940/note:identified by similarity of predicted tertiary structure to PDB 4ol9A,3hn2A,3hwrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ol9A,3hn2A,3hwrA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4ol9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ol9A,Ontology_term=0008677/note:identified by similarity of predicted tertiary structure to PDB 3ghyA,4ol9A,3hn2A,3hwrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ghyA,4ol9A,3hn2A,3hwrA chr1 CDS 2898806 2899309 . + . ID=CDS1;locus_tag=Rv2574;product=conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2899339 2900220 . + . ID=CDS1;locus_tag=Rv2575;product=Possible conserved membrane glycine rich protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2900226 2900690 . - . ID=CDS1;locus_tag=Rv2576c;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2900918 2902507 . + . ID=CDS1;locus_tag=Rv2577;product=conserved protein/putative phosphoric monoester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1warA,1kbpA,2yeqA,3zk4A,4dhlA,3tghA,1xzwB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004035/note:identified by similarity of predicted tertiary structure to PDB 2yeqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yeqA,Ontology_term=0016311/note:identified by similarity of predicted tertiary structure to PDB 1kbpA,2yeqA,3zk4A,4dhlA,1xzwB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kbpA,2yeqA,3zk4A,4dhlA,1xzwB,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1kbpA,4dhlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kbpA,4dhlA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1kbpA,3zk4A,4dhlA,1xzwB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kbpA,3zk4A,4dhlA,1xzwB,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1warA,1kbpA,2yeqA,3zk4A,4dhlA,3tghA,1xzwB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1warA,1kbpA,2yeqA,3zk4A,4dhlA,3tghA,1xzwB,Ontology_term=0008199/note:identified by similarity of predicted tertiary structure to PDB 1kbpA,4dhlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kbpA,4dhlA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1kbpA,4dhlA,1xzwB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1kbpA,4dhlA,1xzwB,Ontology_term=0003993/note:identified by similarity of predicted tertiary structure to PDB 1warA,1kbpA,3zk4A,4dhlA,1xzwB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1warA,1kbpA,3zk4A,4dhlA,1xzwB chr1 CDS 2902509 2903531 . - . ID=CDS1;locus_tag=Rv2578c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2903639 2904541 . + . ID=CDS1;locus_tag=Rv2579;product=Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2904821 2906092 . - . ID=CDS1;locus_tag=Rv2580c;product=Probable histidyl-tRNA synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine--translase);note=FunctionalCategory: information pathways chr1 CDS 2906089 2906763 . - . ID=CDS1;locus_tag=Rv2581c;product=Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2906814 2907740 . + . ID=CDS1;locus_tag=Rv2582;product=Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase);note=FunctionalCategory: information pathways chr1 CDS 2907826 2910198 . - . ID=CDS1;locus_tag=Rv2583c;product=Probable GTP pyrophosphokinase RelA (ATP:GTP 3'- pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2910229 2910867 . - . ID=CDS1;locus_tag=Rv2584c;product=Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2911004 2912677 . - . ID=CDS1;locus_tag=Rv2585c;product=Possible conserved lipoprotein/putative ATP-binding cassette (ABC) transport protein (oligopeptide transport);note=FunctionalCategory: cell wall and cell processes;Ontology_term=0042939/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0043190/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0015833/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0030288/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0015031/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0015197/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA,Ontology_term=0055085/note:identified by similarity of predicted tertiary structure to PDB 3o9pA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o9pA chr1 CDS 2912683 2914011 . - . ID=CDS1;locus_tag=Rv2586c;product=Probable protein-export membrane protein SecF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2914015 2915736 . - . ID=CDS1;locus_tag=Rv2587c;product=Probable protein-export membrane protein SecD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2915846 2916193 . - . ID=CDS1;locus_tag=Rv2588c;product=Probable conserved membrane protein secretion factor YajC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2916360 2917709 . + . ID=CDS1;locus_tag=Rv2589;product=4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2917871 2921377 . + . ID=CDS1;locus_tag=Rv2590;product=Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 2921551 2923182 . + . ID=CDS1;locus_tag=Rv2591;gene=PE_PGRS44;product=PE-PGRS family protein PE_PGRS44;note=FunctionalCategory: PE/PPE chr1 CDS 2923199 2924233 . - . ID=CDS1;locus_tag=Rv2592c;product=Probable holliday junction DNA helicase RuvB;note=FunctionalCategory: information pathways chr1 CDS 2924230 2924820 . - . ID=CDS1;locus_tag=Rv2593c;product=Probable holliday junction DNA helicase RuvA;note=FunctionalCategory: information pathways chr1 CDS 2924817 2925383 . - . ID=CDS1;locus_tag=Rv2594c;product=Probable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase);note=FunctionalCategory: information pathways chr1 CDS 2925492 2925737 . + . ID=CDS1;locus_tag=Rv2595;product=Possible antitoxin VapB40;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2925734 2926138 . + . ID=CDS1;locus_tag=Rv2596;product=Possible toxin VapC40. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2926355 2926975 . + . ID=CDS1;locus_tag=Rv2597;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2926986 2927480 . + . ID=CDS1;locus_tag=Rv2598;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in membrane associated processes based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 2927477 2927908 . + . ID=CDS1;locus_tag=Rv2599;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2927990 2928391 . + . ID=CDS1;locus_tag=Rv2600;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2928388 2929959 . + . ID=CDS1;locus_tag=Rv2601;product=Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2930070 2930357 . + . ID=CDS1;locus_tag=Rv2601A;product=Possible antitoxin VapB41;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2930344 2930784 . + . ID=CDS1;locus_tag=Rv2602;product=Possible toxin VapC41. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 2930805 2931560 . - . ID=CDS1;locus_tag=Rv2603c;product=Highly conserved protein/putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1lfpA1,1lfpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lfpA1,1lfpA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1lfpA1,1lfpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lfpA1,1lfpA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1lfpA1,1lfpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lfpA1,1lfpA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1lfpA1,1lfpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lfpA1,1lfpA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1lfpA1,1lfpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1lfpA1,1lfpA chr1 CDS 2931693 2932289 . - . ID=CDS1;locus_tag=Rv2604c;product=Probable glutamine amidotransferase SnoP;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2932297 2933142 . - . ID=CDS1;locus_tag=Rv2605c;product=Probable acyl-CoA thioesterase II TesB2 (TEII);note=FunctionalCategory: lipid metabolism chr1 CDS 2933171 2934070 . - . ID=CDS1;locus_tag=Rv2606c;product=Possible pyridoxine biosynthesis protein SnzP;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2934198 2934872 . + . ID=CDS1;locus_tag=Rv2607;product=Probable pyridoxamine 5'-phosphate oxidase PdxH (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2935046 2936788 . + . ID=CDS1;locus_tag=Rv2608;gene=PPE42;product=Probable Immunodominant Antigen/PPE family protein PPE42;Experiment=DESCRIPTION:Protein purification and expression in E. coli, ELISA, lymphocyte proliferation assay [PMID: 15346333],Experiment=DESCRIPTION:Recombinant BCG construction, C57BL/6 mice immunization, cytokine production assay, ELISPOT assay for TNF-alpha, ELISA [PMID: 22671973]/note:FunctionalCategory: PE/PPE/note:Elicits a high humoral and a low T cell response in host [PMID: 15346333]/note:Recombinant BCG with Rv2608 elicits stronger cell-mediated response than traditional BCG [PMID: 22671973]/note:Part of an adjuvant protein fusion vaccine (in clinical trial) ID93 [PMID: 22291184] chr1 CDS 2936810 2937865 . - . ID=CDS1;locus_tag=Rv2609c;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2937865 2939001 . - . ID=CDS1;locus_tag=Rv2610c;product=Alpha-mannosyltransferase PimA;note=FunctionalCategory: lipid metabolism chr1 CDS 2939012 2939962 . - . ID=CDS1;locus_tag=Rv2611c;product=Probable acyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 2939959 2940612 . - . ID=CDS1;locus_tag=Rv2612c;product=PI synthase PgsA1 (phosphatidylinositol synthase) (CDP-diacylglycerol--inositol-3-phosphatidyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 2940609 2941196 . - . ID=CDS1;locus_tag=Rv2613c;product=diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase (Ap4A);Experiment=DESCRIPTION:site-directed mutagenesis, protein purification and expression in vitro, crystal structure determination, enzyme activity assays [PMID: 21565198]/note:FunctionalCategory: lipid metabolism/note:contains histidine triad (HIT) motif [PMID: 21565198];EC_number=2.7.7.53 chr1 CDS 2941189 2943267 . - . ID=CDS1;locus_tag=Rv2614c;product=Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2943376 2943603 . + . ID=CDS1;locus_tag=Rv2614A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2943600 2944985 . - . ID=CDS1;locus_tag=Rv2615c;gene=PE_PGRS45;product=PE-PGRS family protein PE_PGRS45;note=FunctionalCategory: PE/PPE, Upregulated in lungs of infected mice (as compared to in vitro control) [PMID: 18054522] chr1 CDS 2945330 2945830 . + . ID=CDS1;locus_tag=Rv2616;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2945847 2946287 . - . ID=CDS1;locus_tag=Rv2617c;product=Probable transmembrane protein;Experiment=DESCRIPTION:bacterial two-hybrid assay, protein-protein interaction assay, protein localization via tagging, western blot [PMID: 19159459]/note:FunctionalCategory: cell wall and cell processes/note:interacts with Exported Repetitive Protein (erp) [PMID:19159459]/note:Highly induced upon nitrosative stress in M. tuberculosis [PMID: 12925133] chr1 CDS 2946434 2947111 . + . ID=CDS1;locus_tag=Rv2618;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2947096 2947449 . - . ID=CDS1;locus_tag=Rv2619c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2947462 2947887 . - . ID=CDS1;locus_tag=Rv2620c;product=Probable conserved transmembrane protein;Experiment=DESCRIPTION:microarray [PMID: 21734908]/note:FunctionalCategory: cell wall and cell processes/note:induced by NO [PMID: 21734908] chr1 CDS 2947884 2948558 . - . ID=CDS1;locus_tag=Rv2621c;product=Possible transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 2948636 2949457 . + . ID=CDS1;locus_tag=Rv2622;product=Possible methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2949593 2950486 . + . ID=CDS1;locus_tag=Rv2623;product=Universal stress protein family protein/T-cell antigen/putative membrane transport protein;Experiment=DESCRIPTION:generation of Rv2623 mutant strain, complemented and overexpression strains, protein expression and purification, gel filtration chromatography, high performance liquid chromatography (HPLC), site-directed mutagenesis [PMID: 19478878],Experiment=DESCRIPTION:expression and purification of cAMP responsive transcription factor (Cmr), western blot analysis, electrophoretic mobility shift assays (EMSA), ChIP-Seq [PMID: 26358810]/inference:ab initio prediction:AutoDock4.2 [PMID: 26964808],Experiment=DESCRIPTION:protein isolation and precipitation, 2D-gel electrophoresis, in-gel digestion and mass spectrometry [PMID: 27895634]/inference:ab initio prediction:InterProScan [PMID: 27895634]/inference:ab initio prediction:Molecular docking [PMID: 27895634]/note:FunctionalCategory: virulence, detoxification, adaptation/note:protein binds ATP and regulates growth of Mycobacterium tuberculosis in vitro and in vivo [PMID: 19478878]/note:predicted to be an ATP-dependent signaling intermediate in a pathway that promotes persistence [PMID: 19478878]/note:potential diagnostic biomarker of latent and active tuberculous meningitis [PMID: 24167379]/note:predicted to be DosR regulated [PMID: 24300592]/note:predicted to be inhibited by truncated INH-NAD adduct [PMID: 26964808]/note:protein is regulated by Cmr (Rv1675c) [PMID: 26358810]/note:over expressed in amikacin and kanamycin resistant isolates and the conserved domain of this gene is predicted to interact with these drugs [PMID: 27895634]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197]/note:identified by similarity of predicted tertiary structure to PDB 3g40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g40A chr1 CDS 2950489 2951307 . - . ID=CDS1;locus_tag=Rv2624c;product=Nucleotide-binding universal stress protein /putative membrane transport protein;Experiment=DESCRIPTION:Whole-blood assay, enzyme-linked immunosorbent assay (ELISA) [PMID: 22260319],Experiment=DESCRIPTION:gene overexpression, site directed mutagenesis, in vitro growth kinetics, macrophage killing assay, HPLC, LC-MS/MS, RNA isolation and sequencing [PMID: 27762279]/note:FunctionalCategory: virulence, detoxification, adaptation/note:DosR regulated antigen [PMID:22260319]/note:overexpression increases mycobacterial survival in human monocytes. Possibly involved in histidine, arginine and proline metabolism. Shown to modulate metabolic pathways in an ATP-dependent manner and changes arginine abundance [PMID:27762279]/note:may modulate metabolic pathways in an ATP-dependent manner, changing the abundance of arginine and increase survival in THP-1 cells. [PMID: 27762279]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197]/note:identified by similarity of predicted tertiary structure to PDB 3g40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g40A chr1 CDS 2951322 2952503 . - . ID=CDS1;locus_tag=Rv2625c;product=Probable conserved transmembrane alanine and leucine rich protein/putative metalloendopeptidase;Experiment=DESCRIPTION:Whole blood assay, IFN-γ ELISA [PMID: 19553548],Experiment=DESCRIPTION:microarray, MGIT assay [PMID: 25645949]/note:FunctionalCategory: cell wall and cell processes/note:DosR encoded antigen [PMID:19553548]/note:upregulated during hypoxia [PMID:25645949]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=3.4.24.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3b4rA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004222/note:identified by similarity of predicted tertiary structure to PDB 3b4rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b4rA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3b4rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b4rA chr1 CDS 2952562 2952993 . - . ID=CDS1;locus_tag=Rv2626c;gene=hrp1;product=Hypoxic response protein 1 Hrp1/Probable Multi-stage Antigen/ Hypoxic response protein 1 Hrp1/Probable Multi-stage Antigen/putative aldose–ketose isomerase/putative oxidoreductase;Experiment=DESCRIPTION:in vitro gene knockout, overexpression, pull down assays, yeast two-hybrid assay [PMID: 26605666],Experiment=gene knockout and complementation, quantitative mass spectrometry, transposon mutagenesis [PMID: 28505176],Experiment=macrophage binding assay, nitrate and cytokine assay, flow cytometry, Electrophoretic mobility shift assay [PMID: 20201990],Experiment=mouse immunization, interferon-gamma ELISA [PMID: 27566581]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to interact with Chloride channel protein 3 (H(+)/Cl(-) exchange transporter 3). [PMID: 28376709]/note:involved in host cell necrosis [PMID: 26605666]/note:essential for macrophage type I interferon response to infection [PMID: 28505176]/note:required for phthiocerol dimycocerosate production [PMID: 28505176]/note:putative component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=1.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3kh5A/inference:ab initio prediction:I-TASSER:5.1,EC_number=5.3.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4o9kA/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 2953507 2954748 . - . ID=CDS1;locus_tag=Rv2627c;product=Conserved protein/putative aminopeptidase;note=FunctionalCategory: conserved hypotheticals, interacts with Erp virulence factor [PMID: 19159459], putative virulence factor, Induces strong IFN-gamma responses in skin test positive individual and immune response against Rv2627c may contribute to the control of latent Mtb infection. [PMID: 27780773], possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=3.4.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB 3azoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3azoA chr1 CDS 2955058 2955420 . + . ID=CDS1;locus_tag=Rv2628;product=Latency Antigen;Experiment=DESCRIPTION:T-cell proliferation assays, Interferon-gamma ELISA [PMID: 16931093],Experiment=DESCRIPTION:Introducing antigen as vaccines to test subjects, isolating peripheral blood mononuclear cells and observing host immune response [PMID: 27489136]/note:FunctionalCategory: conserved hypotheticals/note:Down regulated in otsB2 mutant strain (trehalose-6-phosphate phosphatase silenced strain) [PMID: 27936238]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 2955767 2956891 . + . ID=CDS1;locus_tag=Rv2629;product=putative translation release factor;note=FunctionalCategory: conserved hypotheticals, Associated with rifampicin resistance [PMID:17970586], possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=3.-.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4af1A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0003747/note:identified by similarity of predicted tertiary structure to PDB 4af1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4af1A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4af1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4af1A,Ontology_term=0006415/note:identified by similarity of predicted tertiary structure to PDB 4af1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4af1A,Ontology_term=0006412/note:identified by similarity of predicted tertiary structure to PDB 4af1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4af1A chr1 CDS 2956893 2957432 . + . ID=CDS1;locus_tag=Rv2630;product=Antigen;Experiment=DESCRIPTION:Whole-blood assay, INF-gamma measurement using ELISA [PMID: 23015647]/note:FunctionalCategory: conserved hypotheticals/note:possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 2957572 2958870 . + . ID=CDS1;locus_tag=Rv2631;product=putative RNA ligase;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=6.5.1.-;Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2epgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2epgB,Ontology_term=0016874/note:identified by similarity of predicted tertiary structure to PDB 2epgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2epgB,Ontology_term=0006396/note:identified by similarity of predicted tertiary structure to PDB 2epgB,1uc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2epgB,1uc2A,Ontology_term=0008452/note:identified by similarity of predicted tertiary structure to PDB 2epgB,1uc2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2epgB,1uc2A chr1 CDS 2958909 2959190 . - . ID=CDS1;locus_tag=Rv2632c;product=Conserved protein/putative membrane transport protein;note=FunctionalCategory: conserved hypotheticals, Predicted to interact with DnaK and GroEL2 [PMID: 21134965], identified by similarity of predicted tertiary structure to PDB 4uv2A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uv2A chr1 CDS 2959335 2959820 . - . ID=CDS1;locus_tag=Rv2633c;product=Hypothetical protein;Experiment=DESCRIPTION:microarray expression analysis [PMID: 17501996]/note:FunctionalCategory: conserved hypotheticals/note:putative Cell wall/cell processes/metabolism protein chr1 CDS 2960105 2962441 . - . ID=CDS1;locus_tag=Rv2634c;gene=PE_PGRS46;product=PE-PGRS family protein PE_PGRS46;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642]/note:Upregulated after exposure to capreomycin [PMID: 21678479] chr1 CDS 2962470 2962712 . + . ID=CDS1;locus_tag=Rv2635;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2962713 2963390 . + . ID=CDS1;locus_tag=Rv2636;product=putative phosphotransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3uieA,1m7gC,4bzpA,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0098617/note:identified by similarity of predicted tertiary structure to PDB 1m7gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,Ontology_term=0016310/note:identified by similarity of predicted tertiary structure to PDB 1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA,Ontology_term=0001501/note:identified by similarity of predicted tertiary structure to PDB 1xnjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xnjB,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 1qhxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhxA,Ontology_term=0000103/note:identified by similarity of predicted tertiary structure to PDB 3uieA,1m7gC,4bzpA,5cb6A,1xnjB,2gksB,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uieA,1m7gC,4bzpA,5cb6A,1xnjB,2gksB,2yvuA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA,Ontology_term=0019379/note:identified by similarity of predicted tertiary structure to PDB 2gksB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gksB,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3uieA,1m7gC,4bzpA,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uieA,1m7gC,4bzpA,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1xnjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xnjB,Ontology_term=0016301/note:identified by similarity of predicted tertiary structure to PDB 1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,1qhxA,5cb6A,1xnjB,2gksB,4eunA,2yvuA,Ontology_term=0000096/note:identified by similarity of predicted tertiary structure to PDB 2gksB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gksB,Ontology_term=0004020/note:identified by similarity of predicted tertiary structure to PDB 3uieA,1m7gC,4bzpA,5cb6A,1xnjB,2gksB,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uieA,1m7gC,4bzpA,5cb6A,1xnjB,2gksB,2yvuA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1xnjB,2gksB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xnjB,2gksB,Ontology_term=0046316/note:identified by similarity of predicted tertiary structure to PDB 4eunA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4eunA,Ontology_term=0010134/note:identified by similarity of predicted tertiary structure to PDB 2gksB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gksB,Ontology_term=0050428/note:identified by similarity of predicted tertiary structure to PDB 1xnjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xnjB,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1xnjB,2gksB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xnjB,2gksB,Ontology_term=0004781/note:identified by similarity of predicted tertiary structure to PDB 1xnjB,2gksB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xnjB,2gksB,Ontology_term=0008652/note:identified by similarity of predicted tertiary structure to PDB 1m7gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 1xnjB,2gksB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xnjB,2gksB,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 4eunA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4eunA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1m7gC,1xnjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,1xnjB,Ontology_term=0070814/note:identified by similarity of predicted tertiary structure to PDB 1m7gC,5cb6A,2gksB,2yvuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,5cb6A,2gksB,2yvuA,Ontology_term=0019344/note:identified by similarity of predicted tertiary structure to PDB 1m7gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC,Ontology_term=0009086/note:identified by similarity of predicted tertiary structure to PDB 1m7gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m7gC chr1 CDS 2963586 2964242 . + . ID=CDS1;locus_tag=Rv2637;product=Possible transmembrane protein DedA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2964405 2964851 . + . ID=CDS1;locus_tag=Rv2638;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 4qtpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qtpA,Ontology_term=0045152/note:identified by similarity of predicted tertiary structure to PDB 4qtpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qtpA chr1 CDS 2965026 2965358 . - . ID=CDS1;locus_tag=Rv2639c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2965478 2965837 . - . ID=CDS1;locus_tag=Rv2640c;product=Possible transcriptional regulatory protein (probably ArsR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 2965939 2966397 . + . ID=CDS1;locus_tag=Rv2641;product=Cadmium inducible protein CadI;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2966533 2966913 . + . ID=CDS1;locus_tag=Rv2642;product=putative ArsR transcription factor;Experiment=Recombinant DNA expression, gel retardation assays, DNase I footprinting assay [PMID: 27353442]/inference:alignment: multiple sequence alignment, CLUSTALW, DNAMAN [PMID: 27353442]/inference:protein motif: Multiple Em for Motif Elicitation, MAST [PMID: 27353442]/note:FunctionalCategory: regulatory proteins/note:interacts with the promoter of itself and cadI, possible regulator of arsC/note:potential role in arsenate resistance chr1 CDS 2966910 2968406 . + . ID=CDS1;locus_tag=Rv2643;product=Probable arsenic-transport integral membrane protein ArsC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2968533 2968850 . - . ID=CDS1;locus_tag=Rv2644c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2970123 2970554 . + . ID=CDS1;locus_tag=Rv2645;product=Hypothetical protein;note=FunctionalCategory: unknown chr1 CDS 2970551 2971549 . + . ID=CDS1;locus_tag=Rv2646;product=Probable integrase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2971659 2972027 . + . ID=CDS1;locus_tag=Rv2647;product=Hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2972160 2972486 . + . ID=CDS1;locus_tag=Rv2648;product=Probable transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2972435 2973421 . + . ID=CDS1;locus_tag=Rv2649;product=Probable transposase for insertion sequence element IS6110;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2973795 2975234 . - . ID=CDS1;locus_tag=Rv2650c;product=Possible PhiRv2 prophage protein;note=FunctionalCategory: insertion seqs and phages;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2975242 2975775 . - . ID=CDS1;locus_tag=Rv2651c;product=Possible PhiRv2 prophage protease;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2975928 2976554 . - . ID=CDS1;locus_tag=Rv2652c;product=Probable PhiRv2 prophage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2976586 2976909 . - . ID=CDS1;locus_tag=Rv2653c;product=Possible PhiRv2 prophage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2976989 2977234 . - . ID=CDS1;locus_tag=Rv2654c;product=Possible PhiRv2 prophage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2977231 2978658 . - . ID=CDS1;locus_tag=Rv2655c;product=Possible PhiRv2 prophage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2978660 2979052 . - . ID=CDS1;locus_tag=Rv2656c;product=Possible PhiRv2 prophage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2979049 2979309 . - . ID=CDS1;locus_tag=Rv2657c;product=Probable PhiRv2 prophage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2979326 2979688 . - . ID=CDS1;locus_tag=Rv2658c;product=Possible prophage protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2979691 2980818 . - . ID=CDS1;locus_tag=Rv2659c;product=Probable PhiRv2 prophage integrase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 2980963 2981190 . - . ID=CDS1;locus_tag=Rv2660c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Interacts with Toll-like receptor 2 [PMID: 25622945], Predicted to stimulate human macrophages to maintain latency in Mycobacterium tuberculosis [PMID: 25622945], Could possibly be antigenic, but T cells targeting this protein are transient [PMID: 27733848], Small RNA on the opposite strand is strongly induced during starvation and infection [PMID: 24348997] chr1 CDS 2981187 2981576 . - . ID=CDS1;locus_tag=Rv2661c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2981482 2981754 . + . ID=CDS1;locus_tag=Rv2662;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2981853 2982086 . + . ID=CDS1;locus_tag=Rv2663;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2982097 2982351 . + . ID=CDS1;locus_tag=Rv2664;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2982699 2982980 . + . ID=CDS1;locus_tag=Rv2665;product=Hypothetical arginine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2983071 2983874 . + . ID=CDS1;locus_tag=Rv2666;product=Probable transposase for insertion sequence element IS1081 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 2983896 2984654 . + . ID=CDS1;locus_tag=Rv2667;product=Possible ATP-dependent protease ATP-binding subunit ClpC2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2984733 2985254 . + . ID=CDS1;locus_tag=Rv2668;product=Possible exported alanine and valine rich protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2985283 2985753 . + . ID=CDS1;locus_tag=Rv2669;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2985731 2986840 . - . ID=CDS1;locus_tag=Rv2670c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 2986839 2987615 . + . ID=CDS1;locus_tag=Rv2671;product=Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2987682 2989268 . + . ID=CDS1;locus_tag=Rv2672;product=Possible secreted protease;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2989291 2990592 . + . ID=CDS1;locus_tag=Rv2673;product=Possible arabinofuranosyltransferase AftC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 2990706 2991116 . + . ID=CDS1;locus_tag=Rv2674;product=Probable peptide methionine sulfoxide reductase MsrB (protein-methionine-R-oxide reductase) (peptide met(O) reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2991184 2991936 . - . ID=CDS1;locus_tag=Rv2675c;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 4necA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4necA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 4necA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA chr1 CDS 2991933 2992628 . - . ID=CDS1;locus_tag=Rv2676c;product=Conserved protein/putative peroxidase;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in porphyrin biosynthetic process based on evidence from STRING database (protein-protein interactions)[PMID: 22485162];EC_number=1.11.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4wwsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wwsA,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA,Ontology_term=0033212/note:identified by similarity of predicted tertiary structure to PDB 4grcA,4gt2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4grcA,4gt2B,Ontology_term=0020037/note:identified by similarity of predicted tertiary structure to PDB 2d3qA,4grcA,4gs1A,4gt2B,4gu7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d3qA,4grcA,4gs1A,4gt2B,4gu7A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA,Ontology_term=0005623/note:identified by similarity of predicted tertiary structure to PDB 4grcA,4gt2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4grcA,4gt2B,Ontology_term=0015684/note:identified by similarity of predicted tertiary structure to PDB 4grcA,4gt2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4grcA,4gt2B,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d3qA,4grcA,4gs1A,4gt2B,4gu7A,4wwsA chr1 CDS 2992634 2993992 . - . ID=CDS1;locus_tag=Rv2677c;product=Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2993989 2995062 . - . ID=CDS1;locus_tag=Rv2678c;product=Probable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 2995115 2995945 . + . ID=CDS1;locus_tag=Rv2679;product=Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 2996003 2996737 . + . ID=CDS1;locus_tag=Rv2680;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in DNA/RNA-associated processes based on evidence from STRING database (protein-protein interactions)[PMID: 22485162];Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 2996739 2998055 . + . ID=CDS1;locus_tag=Rv2681;product=putative exonuclease;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.13.-;Ontology_term=0006139/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA,Ontology_term=0008408/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA,Ontology_term=0090305/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA,Ontology_term=0044237/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA,Ontology_term=0003676/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 3cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cymA chr1 CDS 2998052 2999968 . - . ID=CDS1;locus_tag=Rv2682c;product=Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3000112 3000609 . + . ID=CDS1;locus_tag=Rv2683;product=Conserved protein/putative membrane-bound signal transduction protein;note=FunctionalCategory: conserved hypotheticals, contains a CBS domain, identified by similarity of predicted tertiary structure to PDB:4esyA,4nocA,3sl7A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4esyA,4nocA,3sl7A chr1 CDS 3000614 3001903 . + . ID=CDS1;locus_tag=Rv2684;product=Probable arsenic-transport integral membrane protein ArsA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3001983 3003269 . + . ID=CDS1;locus_tag=Rv2685;product=Probable arsenic-transport integral membrane protein ArsB1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3003280 3004038 . - . ID=CDS1;locus_tag=Rv2686c;product=Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3004035 3004748 . - . ID=CDS1;locus_tag=Rv2687c;product=Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3004745 3005650 . - . ID=CDS1;locus_tag=Rv2688c;product=Antibiotic-transport ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3005845 3007062 . - . ID=CDS1;locus_tag=Rv2689c;product=Conserved alanine and valine and glycine rich protein/putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1uwvA,3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,3bt7A,2vs1A,Ontology_term=0030488/note:identified by similarity of predicted tertiary structure to PDB 3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bt7A,2vs1A,Ontology_term=0000049/note:identified by similarity of predicted tertiary structure to PDB 3bt7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bt7A,Ontology_term=0070041/note:identified by similarity of predicted tertiary structure to PDB 1uwvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,3bt7A,2vs1A,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 1uwvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,Ontology_term=0070475/note:identified by similarity of predicted tertiary structure to PDB 1uwvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,3bt7A,2vs1A,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bt7A,2vs1A,Ontology_term=0008173/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,3bt7A,2vs1A,Ontology_term=0030697/note:identified by similarity of predicted tertiary structure to PDB 3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bt7A,2vs1A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,2vs1A,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,2vs1A,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,2vs1A,Ontology_term=0019843/note:identified by similarity of predicted tertiary structure to PDB 3bt7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bt7A,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,2vs1A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3bt7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bt7A,Ontology_term=0006396/note:identified by similarity of predicted tertiary structure to PDB 1uwvA,3bt7A,2vs1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1uwvA,3bt7A,2vs1A chr1 CDS 3007236 3009209 . - . ID=CDS1;locus_tag=Rv2690c;product=Probable conserved integral membrane alanine and valine and leucine rich protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3009344 3010027 . + . ID=CDS1;locus_tag=Rv2691;product=TRK system potassium uptake protein CeoB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3010024 3010686 . + . ID=CDS1;locus_tag=Rv2692;product=TRK system potassium uptake protein CeoC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3010697 3011368 . - . ID=CDS1;locus_tag=Rv2693c;product=Antigen;Experiment=DESCRIPTION:IFN-γ release assay, ELISA [PMID: 25359354]/note:FunctionalCategory: cell wall and cell processes/note:isoniazid causes release of this protein [PMID: 25359354]/note:probable conserved integral membrane alanine and leucine rich protein [TubercuList] chr1 CDS 3011399 3011767 . - . ID=CDS1;locus_tag=Rv2694c;product=Conserved protein/putative ATP hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.4.-;Ontology_term=0006310/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0006281/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0004003/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0032508/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0005730/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0004004/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0006974/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0003676/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0004386/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0010501/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1gm5A,1gm5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gm5A,1gm5A1 chr1 CDS 3011916 3012623 . + . ID=CDS1;locus_tag=Rv2695;product=Probable serine hydrolase/probable serine hydrolase/putative peroxidase/putative carboxylic ester hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.-,EC_number=1.11.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.7.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1c4xA,1u2eA,2pu5A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3hi4A,2xuaA,4uhcA,5egnA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0018771/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0018774/note:identified by similarity of predicted tertiary structure to PDB 1c4xA,2pu5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c4xA,2pu5A,Ontology_term=0047570/note:identified by similarity of predicted tertiary structure to PDB 2xuaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xuaA,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,Ontology_term=0019380/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0005198/note:identified by similarity of predicted tertiary structure to PDB 3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vdxA,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A,Ontology_term=0019622/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4uhcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uhcA,Ontology_term=0004064/note:identified by similarity of predicted tertiary structure to PDB 3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hi4A,Ontology_term=0016823/note:identified by similarity of predicted tertiary structure to PDB 2pu5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pu5A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1c4xA,1u2eA,2pu5A,3hi4A,2xuaA,5egnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1c4xA,1u2eA,2pu5A,3hi4A,2xuaA,5egnA,Ontology_term=0019439/note:identified by similarity of predicted tertiary structure to PDB 1u2eA,2pu5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,2pu5A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA,1a8sA,1a88A,1u2eA,2pu5A,3hi4A,4uhcA,5egnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,1a8sA,1a88A,1u2eA,2pu5A,3hi4A,4uhcA,5egnA,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 4uhcA,5egnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uhcA,5egnA,Ontology_term=0052823/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vdxA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3e3aB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e3aB,Ontology_term=0042952/note:identified by similarity of predicted tertiary structure to PDB 2xuaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xuaA,Ontology_term=0016691/note:identified by similarity of predicted tertiary structure to PDB 1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8sA,1a88A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A chr1 CDS 3012829 3013608 . - . ID=CDS1;locus_tag=Rv2696c;product=Conserved alanine and glycine and valine rich protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in nucleotide metabolism based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 3013683 3014147 . - . ID=CDS1;locus_tag=Rv2697c;product=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase Dut (dUTPase) (dUTP pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dUTP diphosphatase) (deoxyuridine-triphosphatase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3014173 3014658 . + . ID=CDS1;locus_tag=Rv2698;product=Probable conserved alanine rich transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3014663 3014965 . - . ID=CDS1;locus_tag=Rv2699c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3015203 3015853 . + . ID=CDS1;locus_tag=Rv2700;product=Possible conserved secreted alanine rich protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3015863 3016735 . - . ID=CDS1;locus_tag=Rv2701c;product=Inositol-1-monophosphatase SuhB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3016858 3017655 . + . ID=CDS1;locus_tag=Rv2702;product=Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3017835 3019421 . + . ID=CDS1;locus_tag=Rv2703;product=RNA polymerase sigma factor SigA (sigma-A);note=FunctionalCategory: information pathways chr1 CDS 3019458 3019886 . + . ID=CDS1;locus_tag=Rv2704;product=conserved protein /probable ester hydrolase/putative oxo-acid lyase;Experiment=DESCRIPTION:co-expression, co-purification, protein crystallization, crystal structure determination [PMID: 19899170]/note:putative member of the YjgF/YER057c/UK114 family/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:2cwjA/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5a3kA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2cwjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cwjA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 5a3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a3kA,Ontology_term=0016833/note:identified by similarity of predicted tertiary structure to PDB 5a3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a3kA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 5a3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a3kA chr1 CDS 3019814 3020203 . - . ID=CDS1;locus_tag=Rv2705c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3020200 3020457 . - . ID=CDS1;locus_tag=Rv2706c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3020573 3021547 . + . ID=CDS1;locus_tag=Rv2707;product=Probable conserved transmembrane alanine and leucine rich protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be linked to transcription regulation based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 3021548 3021796 . - . ID=CDS1;locus_tag=Rv2708c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to contain an insertion site for IS6110 [PMID: 22703188] chr1 CDS 3021839 3022285 . + . ID=CDS1;locus_tag=Rv2709;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3022461 3023432 . + . ID=CDS1;locus_tag=Rv2710;product=RNA polymerase sigma factor SigB;note=FunctionalCategory: information pathways chr1 CDS 3023565 3024257 . + . ID=CDS1;locus_tag=Rv2711;product=Iron-dependent repressor and activator IdeR;note=FunctionalCategory: regulatory proteins chr1 CDS 3024270 3025328 . - . ID=CDS1;locus_tag=Rv2712c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3025441 3026847 . + . ID=CDS1;locus_tag=Rv2713;product=Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleotide transhydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3027065 3028039 . + . ID=CDS1;locus_tag=Rv2714;product=Conserved alanine and leucine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3028098 3029123 . + . ID=CDS1;locus_tag=Rv2715;product=Possible hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3029172 3029858 . + . ID=CDS1;locus_tag=Rv2716;product=Conserved protein/putative amino acid racemase;note=FunctionalCategory: conserved hypotheticals;EC_number=5.1.1.-;Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1ym5A,3ednA1,1qyaB,4juuA,1ym5A1,1u1wB,3ednA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym5A,3ednA1,1qyaB,4juuA,1ym5A1,1u1wB,3ednA,Ontology_term=0030968/note:identified by similarity of predicted tertiary structure to PDB 1ym5A,1ym5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym5A,1ym5A1,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1ym5A,1u0kA,3ednA1,1s7jA,4dunA,1qyaB,1ym5A1,1u1wB,3ednA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym5A,1u0kA,3ednA1,1s7jA,4dunA,1qyaB,1ym5A1,1u1wB,3ednA,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 1u1wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1wB,Ontology_term=0102943/note:identified by similarity of predicted tertiary structure to PDB 1u1wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1wB,Ontology_term=0009058/note:identified by similarity of predicted tertiary structure to PDB 1ym5A,1u0kA,3ednA1,1s7jA,4dunA,1qyaB,1ym5A1,1u1wB,3ednA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym5A,1u0kA,3ednA1,1s7jA,4dunA,1qyaB,1ym5A1,1u1wB,3ednA,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 1u1wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1wB,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1ym5A,1ym5A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ym5A,1ym5A1,Ontology_term=0002047/note:identified by similarity of predicted tertiary structure to PDB 1u1wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1wB,Ontology_term=0047580/note:identified by similarity of predicted tertiary structure to PDB 4juuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4juuA chr1 CDS 3029867 3030361 . - . ID=CDS1;locus_tag=Rv2717c;product=Conserved protein/putative transport protein;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2q4nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4nA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2q4nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4nA,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 2q4nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q4nA chr1 CDS 3030413 3030877 . - . ID=CDS1;locus_tag=Rv2718c;product=Probable transcriptional regulatory protein NrdR;note=FunctionalCategory: regulatory proteins chr1 CDS 3031040 3031537 . - . ID=CDS1;locus_tag=Rv2719c;product=probable cell wall hydrolase;Experiment=DESCRIPTION:protein purification and expression in vitro, MALDI-TOF MS, zymogram assay, fluorescent cell wall hydrolysis assay [PMID: 16942606],Experiment=DESCRIPTION:measurement of expression levels using quantitative real-time RT-PCR, lacZ reporter construct [PMID: 16885473]/note:FunctionalCategory: cell wall and cell processes/note:potential regulator of cell division [PMID: 16942606]/note:hydrolase activity is targeted at sites of peptidoglycan synthesis [PMID: 16942606]/note:probably DNA damage inducible [PMID: 16885473] chr1 CDS 3031788 3032498 . + . ID=CDS1;locus_tag=Rv2720;product=Repressor LexA;note=FunctionalCategory: regulatory proteins;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3032520 3034619 . - . ID=CDS1;locus_tag=Rv2721c;product=Antigen;Experiment=DESCRIPTION:in vitro overexpression and purification, Interferon-gamma release assay, whole blood culture, intracellular cytokine staining [PMID: 27404979]/note:FunctionalCategory: cell wall and cell processes/note:possible conserved transmembrane alanine and glycine rich protein [TubercuList] chr1 CDS 3034635 3034883 . + . ID=CDS1;locus_tag=Rv2722;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3034909 3036102 . + . ID=CDS1;locus_tag=Rv2723;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3036131 3037291 . - . ID=CDS1;locus_tag=Rv2724c;product=Probable acyl-CoA dehydrogenase FadE20;note=FunctionalCategory: lipid metabolism chr1 CDS 3037427 3038914 . - . ID=CDS1;locus_tag=Rv2725c;product=Probable GTP-binding protein HflX;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3038931 3039800 . - . ID=CDS1;locus_tag=Rv2726c;product=Probable diaminopimelate epimerase DapF (DAP epimerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3039825 3040769 . - . ID=CDS1;locus_tag=Rv2727c;product=Probable tRNA delta(2)-isopentenylpyrophosphate transferase MiaA (IPP transferase) (isopentenyl-diphosphate:tRNA isopentenyltransferase) (iptase) (IPPT);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3040766 3041461 . - . ID=CDS1;locus_tag=Rv2728c;product=Conserved alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3041570 3042475 . - . ID=CDS1;locus_tag=Rv2729c;product=Probable conserved integral membrane alanine valine and leucine rich protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3042542 3043018 . + . ID=CDS1;locus_tag=Rv2730;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3043026 3044378 . + . ID=CDS1;locus_tag=Rv2731;product=Conserved alanine and arginine rich protein;note=FunctionalCategory: conserved hypotheticals, homolog (73% homology) in M.smegmatis is predicted to bind to RNA and interact with 30S ribosomal protein S1, hence may a play a role in transcription/translation [PMID: 22590585], potentially involved in cell division regulation, high structural similarity to a spectrin-like regulator of cytokinesis, identified by similarity of predicted tertiary structure to PDB 4uxvA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uxvA chr1 CDS 3044375 3044986 . - . ID=CDS1;locus_tag=Rv2732c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3044986 3046524 . - . ID=CDS1;locus_tag=Rv2733c;product=putative protein methylthiotransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.8.4.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0006400/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0103039/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0018339/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4jc0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jc0A chr1 CDS 3046821 3047675 . + . ID=CDS1;locus_tag=Rv2734;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3047560 3048552 . - . ID=CDS1;locus_tag=Rv2735c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to interact with aminoglycoside 2'-N-acetyltransferase [PMID: 23519100] chr1 CDS 3048562 3049086 . - . ID=CDS1;locus_tag=Rv2736c;product=Regulatory protein RecX;note=FunctionalCategory: information pathways chr1 CDS 3049052 3051424 . - . ID=CDS1;locus_tag=Rv2737c;product=RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].;note=FunctionalCategory: information pathways chr1 CDS 3051619 3051792 . + . ID=CDS1;locus_tag=Rv2737A;product=Conserved hypothetical cysteine rich protein (fragment);note=FunctionalCategory: conserved hypotheticals chr1 CDS 3051806 3052012 . - . ID=CDS1;locus_tag=Rv2738c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3052023 3053189 . - . ID=CDS1;locus_tag=Rv2739c;product=Possible alanine rich transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3053233 3053682 . + . ID=CDS1;locus_tag=Rv2740;product=Epoxide hydrolase;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3053914 3055491 . + . ID=CDS1;locus_tag=Rv2741;gene=PE_PGRS47;product=Probable antigen/PE-PGRS family protein PE_PGRS47;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=DESCRIPTION:Protein expression and purification, indirect ELISA [PMID: 20690665],Experiment=DESCRIPTION:Targeted gene disruption, interferon-gamma quantitation via ELISPOT, ELISA, Fluorescence-activated cell sorting (FACS) analysis, fluorescence microscopy [PMID: 27562263]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642]/note:Inhibits autophagy in host macrophages during infection [PMID: 27562263]/note:Inhibits MHC Class II antigen presentation in host cells [PMID: 27562263]/note:FunctionalCategory: PE/PPE chr1 CDS 3055515 3056348 . - . ID=CDS1;locus_tag=Rv2742c;product=Conserved hypothetical arginine rich protein;note=FunctionalCategory: conserved hypotheticals, This gene is absent in nontuberculous Mycobacterium species [PMID: 27002134] chr1 CDS 3056420 3057232 . - . ID=CDS1;locus_tag=Rv2743c;product=Possible conserved transmembrane alanine rich protein;Experiment=SDS treatment, CCCP treatment, protein expression in E. Coli, immunoprecipitation, pull-down assays [PMID: 25899163]/inference:similar to AA sequence:BLOSUM62 matrix via Geneious Pro, BLASTp [PMID: 25899163]/inference:ab initio prediction: PHYRE [PMID: 25899163]/inference:protein motif:InterProScan [PMID: 25899163]/note:FunctionalCategory: cell wall and cell processes/note:induced by MprAB-σE during cell surface stress [PMID: 25899163] chr1 CDS 3057251 3058063 . - . ID=CDS1;locus_tag=Rv2744c;gene=pspA;product=phage shock protein A (PspA);Experiment=DESCRIPTION:deletion mutant construction, lipid droplet purification, electron microscopy, bacterial two-hybrid assay, western blot [PMID: 27002134]/note:FunctionalCategory: conserved hypotheticals/note:Ofloxacin is predicted to bind within the region of conserved domain of this protein (Molecular docking analysis) [PMID: 26238929]/note:over expressed in amikacin and kanamycin resistant isolates [PMID: 27895634] chr1 CDS 3058193 3058531 . - . ID=CDS1;locus_tag=Rv2745c;product=Transcriptional regulatory protein ClgR;note=FunctionalCategory: regulatory proteins chr1 CDS 3058602 3059201 . - . ID=CDS1;locus_tag=Rv2746c;product=Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase) (phosphatidylglycerophosphate synthase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3059262 3059786 . + . ID=CDS1;locus_tag=Rv2747;product=Probable L-glutamate alpha-N-acetyltranferase ArgA (alpha-N-acetylglutamate synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3059855 3062506 . - . ID=CDS1;locus_tag=Rv2748c;product=Possible cell division transmembrane protein FtsK;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3062505 3062819 . + . ID=CDS1;locus_tag=Rv2749;product=Conserved protein/putative dioxygenase;note=FunctionalCategory: conserved hypotheticals, Predicted to be linked to less specific oxidoreductase activity based on evidence from STRING database (protein-protein interactions)[PMID: 22485162];EC_number=1.13.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2cb2A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2cb2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cb2A,Ontology_term=0033755/note:identified by similarity of predicted tertiary structure to PDB 2cb2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cb2A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2cb2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cb2A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2cb2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cb2A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2cb2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cb2A chr1 CDS 3062816 3063634 . + . ID=CDS1;locus_tag=Rv2750;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3063638 3064528 . + . ID=CDS1;locus_tag=Rv2751;product=Conserved protein/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3bgvC,2zwaB,4gekA,1rjeC,2a14A,2ckdA,3vc1A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0002098/note:identified by similarity of predicted tertiary structure to PDB 4gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gekA,Ontology_term=0031591/note:identified by similarity of predicted tertiary structure to PDB 2zwaB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,Ontology_term=0008169/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2zwaB,4gekA,1rjeC,2a14A,2ckdA,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,4gekA,1rjeC,2a14A,2ckdA,3vc1A,Ontology_term=0004790/note:identified by similarity of predicted tertiary structure to PDB 2a14A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a14A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2zwaB,2a14A,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,2a14A,3vc1A,Ontology_term=0006481/note:identified by similarity of predicted tertiary structure to PDB 1rjeC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rjeC,Ontology_term=0016743/note:identified by similarity of predicted tertiary structure to PDB 4gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gekA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3bgvC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bgvC,Ontology_term=0009636/note:identified by similarity of predicted tertiary structure to PDB 2a14A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a14A,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 2zwaB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,Ontology_term=0042214/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2zwaB,4gekA,1rjeC,2a14A,2ckdA,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,4gekA,1rjeC,2a14A,2ckdA,3vc1A,Ontology_term=0006400/note:identified by similarity of predicted tertiary structure to PDB 2zwaB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,Ontology_term=0010506/note:identified by similarity of predicted tertiary structure to PDB 1rjeC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rjeC,Ontology_term=0018423/note:identified by similarity of predicted tertiary structure to PDB 1rjeC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rjeC,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 2zwaB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,Ontology_term=0009308/note:identified by similarity of predicted tertiary structure to PDB 2a14A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a14A,Ontology_term=0008757/note:identified by similarity of predicted tertiary structure to PDB 2zwaB,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,3vc1A,Ontology_term=0004482/note:identified by similarity of predicted tertiary structure to PDB 3bgvC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bgvC,Ontology_term=0102707/note:identified by similarity of predicted tertiary structure to PDB 2a14A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a14A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0008175/note:identified by similarity of predicted tertiary structure to PDB 2zwaB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,Ontology_term=0043623/note:identified by similarity of predicted tertiary structure to PDB 1rjeC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rjeC,Ontology_term=0030488/note:identified by similarity of predicted tertiary structure to PDB 2zwaB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2zwaB,4gekA,1rjeC,2a14A,2ckdA,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,4gekA,1rjeC,2a14A,2ckdA,3vc1A,Ontology_term=1904047/note:identified by similarity of predicted tertiary structure to PDB 4gekA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gekA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2zwaB,1rjeC,2a14A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2zwaB,1rjeC,2a14A,Ontology_term=0030748/note:identified by similarity of predicted tertiary structure to PDB 2a14A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a14A,Ontology_term=0006370/note:identified by similarity of predicted tertiary structure to PDB 3bgvC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bgvC,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2a14A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a14A chr1 CDS 3064515 3066191 . - . ID=CDS1;locus_tag=Rv2752c;product=Probable beta-lactamase/RNase;Experiment=DESCRIPTION:Bacterial two-hybrid analysis, co-expression/co-purification, western blot, starch/iodine coloration assay, RNase activity assay, spectrophormetric assay [PMID: 21568871],Experiment=DESCRIPTION:Expression and purification of protein, Beta-lactamase activity analysis [PMID: 19298676]/inference:similar to AA sequence: SWISS-MODEL [PMID: 21568871]/note:FunctionalCategory: conserved hypotheticals/note:Dual function protein;EC_number=3.1.-.-,EC_number=3.5.2.6 chr1 CDS 3066222 3067124 . - . ID=CDS1;locus_tag=Rv2753c;product=Probable dihydrodipicolinate synthase DapA (DHDPS) (dihydrodipicolinate synthetase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3067193 3067945 . - . ID=CDS1;locus_tag=Rv2754c;product=Probable thymidylate synthase ThyX (ts) (TSase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3068189 3068464 . - . ID=CDS1;locus_tag=Rv2755c;product=Possible type I restriction/modification system specificity determinant (fragment) HsdS.1 (S protein);note=FunctionalCategory: information pathways chr1 CDS 3068461 3070083 . - . ID=CDS1;locus_tag=Rv2756c;product=Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase);note=FunctionalCategory: information pathways chr1 CDS 3070170 3070586 . - . ID=CDS1;locus_tag=Rv2757c;product=Possible toxin VapC21;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3070583 3070849 . - . ID=CDS1;locus_tag=Rv2758c;product=Possible antitoxin VapB21;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3070875 3071270 . - . ID=CDS1;locus_tag=Rv2759c;product=Possible toxin VapC42. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3071267 3071536 . - . ID=CDS1;locus_tag=Rv2760c;product=Possible antitoxin VapB42;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3071546 3072640 . - . ID=CDS1;locus_tag=Rv2761c;product=Possible type I restriction/modification system specificity determinant HsdS (S protein);note=FunctionalCategory: information pathways chr1 CDS 3072637 3073056 . - . ID=CDS1;locus_tag=Rv2762c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3073130 3073609 . - . ID=CDS1;locus_tag=Rv2763c;product=Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3073680 3074471 . - . ID=CDS1;locus_tag=Rv2764c;product=Probable thymidylate synthase ThyA (ts) (TSASE);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3074636 3075373 . + . ID=CDS1;locus_tag=Rv2765;product=Probable alanine rich hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3075588 3076370 . - . ID=CDS1;locus_tag=Rv2766c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3076367 3076720 . - . ID=CDS1;locus_tag=Rv2767c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3076894 3078078 . - . ID=CDS1;locus_tag=Rv2768c;gene=PPE43;product=PPE family protein PPE43;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642]/note:Hypothesized to have been duplicated from ESAT-6 (esx) gene cluster region 5 [PMID: 17105670] chr1 CDS 3078158 3078985 . - . ID=CDS1;locus_tag=Rv2769c;gene=PE27;product=PE family protein PE27;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=DESCRIPTION:Cytotoxicity analysis, antigen uptake of dendritic cells (in the presence of PE27), analysis of T-cell response [PMID: 26655143]/note:FunctionalCategory: PE/PPE/note:Phenotypically and functionally induces dendritic cell maturation by up-regulating CD80 and CD86 [PMID: 26655143]/note:Mediates dendritic cell activation via triggering the phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor kB (NF-kB) signaling pathways [PMID: 26655143]/note:Induces the phosphorylation of and degradation of IkB-alpha and p65 translocation from the cytosol to the nucleus [PMID: 26655143]/note:Contributes to TH1-polarization during in vivo infection [PMID: 26655143]/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection [PMID: 21085642] chr1 CDS 3079309 3080457 . - . ID=CDS1;locus_tag=Rv2770c;gene=PPE44;product=Protective B cell and T-cell antigen;Experiment=DESCRIPTION:Protein expression and purification, intravenous infection to mice, antibody ELISA, interferon-gamma quantification by sandwich ELISA, in vivo CTL activity assay [PMID: 18822333],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Induces B and T cell responses [PMID: 18822333]/note:Polarizes the immune response towards the Th2 phenotype based on IgG1/IgG2a ratio [PMID: 15824420]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 3080581 3081033 . - . ID=CDS1;locus_tag=Rv2771c;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.6.5.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4la4A,1ydgE,2r97A,1zwlA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0046196/note:identified by similarity of predicted tertiary structure to PDB 4la4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4la4A,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 2r97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r97A,Ontology_term=0003955/note:identified by similarity of predicted tertiary structure to PDB 4la4A,1ydgE,2r97A,1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4la4A,1ydgE,2r97A,1zwlA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4la4A,1ydgE,2r97A,1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4la4A,1ydgE,2r97A,1zwlA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2r97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r97A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1ydgE,2r97A,1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ydgE,2r97A,1zwlA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2r97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r97A,Ontology_term=0010181/note:identified by similarity of predicted tertiary structure to PDB 4la4A,1ydgE,2r97A,1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4la4A,1ydgE,2r97A,1zwlA,Ontology_term=0034599/note:identified by similarity of predicted tertiary structure to PDB 1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zwlA,Ontology_term=0006979/note:identified by similarity of predicted tertiary structure to PDB 2r97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r97A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4la4A,1ydgE,2r97A,1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4la4A,1ydgE,2r97A,1zwlA,Ontology_term=0009055/note:identified by similarity of predicted tertiary structure to PDB 1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zwlA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2r97A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r97A,Ontology_term=0016655/note:identified by similarity of predicted tertiary structure to PDB 1zwlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zwlA,Ontology_term=0019439/note:identified by similarity of predicted tertiary structure to PDB 4la4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4la4A chr1 CDS 3081119 3081592 . - . ID=CDS1;locus_tag=Rv2772c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3081604 3082341 . - . ID=CDS1;locus_tag=Rv2773c;product=Dihydrodipicolinate reductase DapB (DHPR);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3082352 3082756 . - . ID=CDS1;locus_tag=Rv2774c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3082909 3083370 . + . ID=CDS1;locus_tag=Rv2775;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3083374 3084303 . - . ID=CDS1;locus_tag=Rv2776c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3084485 3085555 . - . ID=CDS1;locus_tag=Rv2777c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3085713 3086183 . - . ID=CDS1;locus_tag=Rv2778c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3086215 3086754 . - . ID=CDS1;locus_tag=Rv2779c;product=Possible transcriptional regulatory protein (probably Lrp/AsnC-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3086820 3087935 . + . ID=CDS1;locus_tag=Rv2780;product=Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3087950 3088984 . - . ID=CDS1;locus_tag=Rv2781c;product=Putative nitronate monooxygenase;Experiment=DESCRIPTION:recombinant DNA expression, enzyme activity assay, inhibition assay [PMID: 23408846]/note:FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3089045 3090361 . - . ID=CDS1;locus_tag=Rv2782c;product=Probable zinc protease PepR;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3090339 3092597 . - . ID=CDS1;locus_tag=Rv2783c;product=Bifunctional protein polyribonucleotide nucleotidyltransferase GpsI: guanosine pentaphosphate synthetase + polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) (pnpase);note=FunctionalCategory: information pathways chr1 CDS 3092951 3093466 . - . ID=CDS1;locus_tag=Rv2784c;product=Probable lipoprotein LppU;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3093479 3093748 . - . ID=CDS1;locus_tag=Rv2785c;product=30S ribosomal protein S15 RpsO;note=FunctionalCategory: information pathways chr1 CDS 3093905 3094900 . - . ID=CDS1;locus_tag=Rv2786c;product=Probable bifunctional FAD synthetase/riboflavin biosynthesis protein RibF: riboflavin kinase (flavokinase) + FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)(FAD diphosphorylase) (flavin adenine dinucleotide synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3095111 3096874 . + . ID=CDS1;locus_tag=Rv2787;product=Conserved hypothetical alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3096959 3097645 . + . ID=CDS1;locus_tag=Rv2788;product=Probable transcriptional repressor SirR;note=FunctionalCategory: regulatory proteins chr1 CDS 3097706 3098938 . - . ID=CDS1;locus_tag=Rv2789c;product=Probable acyl-CoA dehydrogenase FadE21;note=FunctionalCategory: lipid metabolism chr1 CDS 3098964 3100169 . - . ID=CDS1;locus_tag=Rv2790c;product=Probable lipid-transfer protein Ltp1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3100202 3101581 . - . ID=CDS1;locus_tag=Rv2791c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3101581 3102162 . - . ID=CDS1;locus_tag=Rv2792c;product=Possible resolvase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3102364 3103260 . - . ID=CDS1;locus_tag=Rv2793c;product=Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase);note=FunctionalCategory: information pathways chr1 CDS 3103257 3103940 . - . ID=CDS1;locus_tag=Rv2794c;product=Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 3103937 3104911 . - . ID=CDS1;locus_tag=Rv2795c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3105056 3105619 . - . ID=CDS1;locus_tag=Rv2796c;product=Probable conserved lipoprotein LppV;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3105619 3107307 . - . ID=CDS1;locus_tag=Rv2797c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in lipid metabolism based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 3107311 3107637 . - . ID=CDS1;locus_tag=Rv2798c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3107768 3108397 . + . ID=CDS1;locus_tag=Rv2799;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3108416 3110065 . + . ID=CDS1;locus_tag=Rv2800;product=Possible hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3110167 3110523 . - . ID=CDS1;locus_tag=Rv2801c;product=Toxin MazF9;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3110507 3110737 . - . ID=CDS1;locus_tag=Rv2801A;product=Possible antitoxin MazE9;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3110780 3111823 . - . ID=CDS1;locus_tag=Rv2802c;product=Hypothetical arginine and alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3111822 3112289 . + . ID=CDS1;locus_tag=Rv2803;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3112465 3113094 . - . ID=CDS1;locus_tag=Rv2804c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3112867 3113271 . + . ID=CDS1;locus_tag=Rv2805;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3113268 3113459 . + . ID=CDS1;locus_tag=Rv2806;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3113658 3114812 . + . ID=CDS1;locus_tag=Rv2807;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3115046 3115303 . + . ID=CDS1;locus_tag=Rv2808;product=hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in membrane associated processes based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 3115408 3115719 . + . ID=CDS1;locus_tag=Rv2809;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3115741 3116142 . - . ID=CDS1;locus_tag=Rv2810c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3116139 3116747 . + . ID=CDS1;locus_tag=Rv2811;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3116818 3118227 . + . ID=CDS1;locus_tag=Rv2812;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3118224 3119036 . + . ID=CDS1;locus_tag=Rv2813;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3120566 3121552 . - . ID=CDS1;locus_tag=Rv2814c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3121501 3121827 . - . ID=CDS1;locus_tag=Rv2815c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3123625 3123966 . - . ID=CDS1;locus_tag=Rv2816c;gene=Cas2;product=putative endoribonuclease;Experiment=DESCRIPTION:in vitro recombinant gene expression, in vitro and intracellular survival assays, RT-PCR drug susceptibility assay [PMID: 26498723]/note:FunctionalCategory: conserved hypotheticals/note:alters expression of sigma factors/note:involved in stress response and virulence/note:CRISPR-associated;EC_number=3.1.-.- chr1 CDS 3123967 3124983 . - . ID=CDS1;locus_tag=Rv2817c;product=putative endodeoxyribonuclease;note=FunctionalCategory: conserved hypotheticals, Predicted to contain an insertion site for IS6110 [PMID: 22703188], Essential gene for MTBC growth in vitro. [PMID: 28201993];EC_number=3.1.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0051607/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0004520/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0090305/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0003676/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0043571/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2yzsB2,2yzsB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yzsB2,2yzsB chr1 CDS 3124996 3126144 . - . ID=CDS1;locus_tag=Rv2818c;product=putative CRISPR-associated ribonuclease;note=FunctionalCategory: unknown;EC_number=3.1.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB 5fshA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5fshA chr1 CDS 3126240 3127367 . - . ID=CDS1;locus_tag=Rv2819c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3127364 3128272 . - . ID=CDS1;locus_tag=Rv2820c;product=putative CRISPR associated RNA-binding protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be associated with virulence [PMID: 21362467], Likely a CRISPR-associated (cas) gene [PMID: 11952905], potential CRISPR type III-A, identified by similarity of predicted tertiary structure to PDB 4qtsA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qtsA chr1 CDS 3128253 3128963 . - . ID=CDS1;locus_tag=Rv2821c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3128973 3129347 . - . ID=CDS1;locus_tag=Rv2822c;product=putative CRISPR associated protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in DNA repair mechanisms based on evidence from STRING database (protein-protein interactions)[PMID: 22485162], potential CRISPR type III-A, identified by similarity of predicted tertiary structure to PDB 5an6A;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5an6A chr1 CDS 3129344 3131773 . - . ID=CDS1;locus_tag=Rv2823c;product=Conserved protein/putative CRISPR associated endonuclease/exonuclease;note=FunctionalCategory: conserved hypotheticals, Predicted to contain an insertion site for IS6110 [PMID: 23985924];EC_number=3.1.-.- (Putative)/note:potential CRISPR type III-A/note:identified by similarity of predicted tertiary structure to PDB 4uw2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uw2A chr1 CDS 3131770 3132714 . - . ID=CDS1;locus_tag=Rv2824c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in DNA repair mechanisms based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 3132892 3133539 . - . ID=CDS1;locus_tag=Rv2825c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3133709 3134593 . - . ID=CDS1;locus_tag=Rv2826c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Possible Type IV toxin [PMID: 24662523] chr1 CDS 3134596 3135483 . - . ID=CDS1;locus_tag=Rv2827c;product=Hypothetical protein;note=Possible Type IV antitoxin [PMID: 24662523], FunctionalCategory: conserved hypotheticals, Structure solved but function still unknown, Binds DNA, identified by similarity of predicted tertiary structure to PDB 1zelB;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1zelB chr1 CDS 3135788 3136333 . - . ID=CDS1;locus_tag=Rv2828c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3136330 3136599 . - . ID=CDS1;locus_tag=Rv2828A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3136620 3137012 . - . ID=CDS1;locus_tag=Rv2829c;product=Possible toxin VapC22;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3137009 3137224 . - . ID=CDS1;locus_tag=Rv2830c;product=Possible antitoxin VapB22;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3137271 3138020 . + . ID=CDS1;locus_tag=Rv2831;product=Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 3138099 3139181 . - . ID=CDS1;locus_tag=Rv2832c;product=Probable Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UgpC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3139174 3140484 . - . ID=CDS1;locus_tag=Rv2833c;product=Probable Sn-glycerol-3-phosphate-binding lipoprotein UgpB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3140487 3141314 . - . ID=CDS1;locus_tag=Rv2834c;product=Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3141311 3142222 . - . ID=CDS1;locus_tag=Rv2835c;product=Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3142309 3143628 . - . ID=CDS1;locus_tag=Rv2836c;product=Possible DNA-damage-inducible protein F DinF;note=FunctionalCategory: information pathways chr1 CDS 3143635 3144645 . - . ID=CDS1;locus_tag=Rv2837c;gene=nrnA;product=nanoRNase A (NrnA): PAP phosphatase (3'-phosphoadenosine 5'-phosphate phosphatase)/ cyclic-dinucleotide-AMP specific phosphodiesterase (3'(2'),5'-bisphosphate nucleotidase);Experiment=DESCRIPTION:protein expression and purification, enzyme activity assay, Matrix Assisted Laser Desorption/Ionization[PMID: 24465894],Experiment=DESCRIPTION:protein expression and purification, complementation, nanoRNase activity assay, [PMID: 22114320],Experiment=DESCRIPTION:phosphodiesterase activity assay, LC-MS, Circular Dichroism, protein crystallization, mobility assays [PMID: 26668313]/note:FunctionalCategory: conserved hypotheticals/note:c-di-AMP hydrolyzed sequentially in two-steps: 5′-phosphate di adenosine nucleotide (pApA) which is further hydrolyzed to 5′-AMP [PMID: 24465894]/note:putative ci-diGMP phosphodiesterase [PMID: 26668313]/note:dual-function/note:preferentially degrades 2-mer RNA oligimers [PMID: 22114320];EC_number=3.1.-.-,EC_number=3.1.3.7 chr1 CDS 3144620 3145171 . - . ID=CDS1;locus_tag=Rv2838c;product=Probable ribosome-binding factor a RbfA (P15B protein);note=FunctionalCategory: information pathways chr1 CDS 3145171 3147873 . - . ID=CDS1;locus_tag=Rv2839c;product=Probable translation initiation factor if-2 InfB;note=FunctionalCategory: information pathways chr1 CDS 3147959 3148258 . - . ID=CDS1;locus_tag=Rv2840c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3148385 3149428 . - . ID=CDS1;locus_tag=Rv2841c;product=Probable N utilization substance protein A NusA;note=FunctionalCategory: information pathways chr1 CDS 3149425 3149976 . - . ID=CDS1;locus_tag=Rv2842c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Predicted to be involved in transcription/translation based on evidence from STRING database (protein-protein interactions)[PMID: 22485162] chr1 CDS 3150171 3150716 . + . ID=CDS1;locus_tag=Rv2843;product=Probable conserved transmembrane alanine rich protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3150713 3151201 . + . ID=CDS1;locus_tag=Rv2844;product=Conserved alanine rich protein;Experiment=DESCRIPTION:transposon mutagenesis, susceptibility testing, phase-contrast microscopy [PMID: 15743935],Experiment=DESCRIPTION:high throughput crystallography, protein crystallization and structure determination, MALDI-TOF, X-ray diffraction [PMID: 17970224]/note:FunctionalCategory: conserved hypotheticals/note:Conserved putative cell envelope process protein/note:Possible metal binding protein [PMID: 17970224],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3151202 3152950 . - . ID=CDS1;locus_tag=Rv2845c;product=Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase);note=FunctionalCategory: information pathways chr1 CDS 3153039 3154631 . - . ID=CDS1;locus_tag=Rv2846c;product=Possible integral membrane efflux protein EfpA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3154654 3155871 . - . ID=CDS1;locus_tag=Rv2847c;product=Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3156148 3157521 . - . ID=CDS1;locus_tag=Rv2848c;product=Probable cobyrinic acid A,C-diamide synthase CobB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3157521 3158144 . - . ID=CDS1;locus_tag=Rv2849c;product=Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3158165 3160054 . - . ID=CDS1;locus_tag=Rv2850c;product=Possible magnesium chelatase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3160051 3160521 . - . ID=CDS1;locus_tag=Rv2851c;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3160580 3162061 . - . ID=CDS1;locus_tag=Rv2852c;product=Probable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor]);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3162268 3164115 . + . ID=CDS1;locus_tag=Rv2853;gene=PE_PGRS48;product=PE-PGRS family protein PE_PGRS48/T-cell antigen;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=DESCRIPTION:Ex-vivo interferon-gamma ELISPOT assay [PMID: 26277695]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642] chr1 CDS 3164152 3165192 . + . ID=CDS1;locus_tag=Rv2854;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3165205 3166584 . + . ID=CDS1;locus_tag=Rv2855;product=NADPH-dependent mycothiol reductase Mtr;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3166684 3167802 . + . ID=CDS1;locus_tag=Rv2856;product=Possible nickel-transport integral membrane protein NicT;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3168583 3169359 . - . ID=CDS1;locus_tag=Rv2857c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3169356 3170723 . - . ID=CDS1;locus_tag=Rv2858c;product=Probable aldehyde dehydrogenase AldC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3170720 3171646 . - . ID=CDS1;locus_tag=Rv2859c;product=Possible amidotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3171627 3173000 . - . ID=CDS1;locus_tag=Rv2860c;product=Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3173160 3174017 . - . ID=CDS1;locus_tag=Rv2861c;product=Methionine aminopeptidase MapB (map) (peptidase M);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3174059 3174643 . - . ID=CDS1;locus_tag=Rv2862c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3174747 3174995 . + . ID=CDS1;locus_tag=Rv2862A;product=Possible antitoxin VapB23;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3174992 3175372 . + . ID=CDS1;locus_tag=Rv2863;product=Possible toxin VapC23;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3175454 3177265 . - . ID=CDS1;locus_tag=Rv2864c;product=Possible penicillin-binding lipoprotein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3177537 3177818 . + . ID=CDS1;locus_tag=Rv2865;product=Antitoxin RelF;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3177822 3178085 . + . ID=CDS1;locus_tag=Rv2866;product=Toxin RelG;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3178458 3179312 . - . ID=CDS1;locus_tag=Rv2867c;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3179368 3180531 . - . ID=CDS1;locus_tag=Rv2868c;gene=gcpE;product=Probable (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin);note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=1.17.7.3 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2y0fA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0019288/note:identified by similarity of predicted tertiary structure to PDB 3noyA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,2y0fA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3noyA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,2y0fA,Ontology_term=0005506/note:identified by similarity of predicted tertiary structure to PDB 3noyA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,2y0fA,Ontology_term=0046429/note:identified by similarity of predicted tertiary structure to PDB 3noyA,4mwaA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,4mwaA,2y0fA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2y0fA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3noyA,4mwaA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,4mwaA,2y0fA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3noyA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,2y0fA,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 3noyA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,2y0fA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 3noyA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,2y0fA,Ontology_term=0044237/note:identified by similarity of predicted tertiary structure to PDB 4mwaA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4mwaA,2y0fA,Ontology_term=0008299/note:identified by similarity of predicted tertiary structure to PDB 3noyA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,2y0fA,Ontology_term=0016114/note:identified by similarity of predicted tertiary structure to PDB 3noyA,4mwaA,2y0fA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3noyA,4mwaA,2y0fA chr1 CDS 3180548 3181762 . - . ID=CDS1;locus_tag=Rv2869c;product=Membrane bound metalloprotease;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3181770 3183011 . - . ID=CDS1;locus_tag=Rv2870c;product=Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3183138 3183395 . + . ID=CDS1;locus_tag=Rv2871;product=Possible antitoxin VapB43;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3183382 3183825 . + . ID=CDS1;locus_tag=Rv2872;product=Possible toxin VapC43. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3183905 3184567 . + . ID=CDS1;locus_tag=Rv2873;product=Cell surface lipoprotein Mpt83 (lipoprotein P23);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3184847 3186934 . + . ID=CDS1;locus_tag=Rv2874;product=Possible integral membrane C-type cytochrome biogenesis protein DipZ;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3187030 3187611 . + . ID=CDS1;locus_tag=Rv2875;product=Major secreted immunogenic protein Mpt70;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3187663 3187977 . + . ID=CDS1;locus_tag=Rv2876;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3188008 3188871 . - . ID=CDS1;locus_tag=Rv2877c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes, homologous to a putative cytochrome C biogenesis protein. [PMID: 20030828], Upregulated in SigL overexpression studies [PMID: 16552079] chr1 CDS 3188876 3189397 . - . ID=CDS1;locus_tag=Rv2878c;product=Soluble secreted antigen Mpt53 precursor;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3189583 3190152 . - . ID=CDS1;locus_tag=Rv2879c;product=Putative 23S rRNA (adenine(2503)-C(2))-methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.192 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3rf9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0008173/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0002935/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0000049/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0070040/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0070475/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0030488/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A chr1 CDS 3189851 3190678 . - . ID=CDS1;locus_tag=Rv2880c;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3rf9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0030488/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0000049/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0070040/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0070475/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0008173/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0002935/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3rf9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3rf9A chr1 CDS 3190701 3191621 . - . ID=CDS1;locus_tag=Rv2881c;product=Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3191644 3192201 . - . ID=CDS1;locus_tag=Rv2882c;product=Ribosome recycling factor Frr (ribosome releasing factor) (RRF);note=FunctionalCategory: information pathways chr1 CDS 3192373 3193158 . - . ID=CDS1;locus_tag=Rv2883c;product=Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3193393 3194151 . + . ID=CDS1;locus_tag=Rv2884;product=Probable transcriptional regulatory protein/putative transcriptional activator;note=FunctionalCategory: regulatory proteins;Ontology_term=0001140/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0000160/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0001131/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0001121/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0000986/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA,Ontology_term=0045893/note:identified by similarity of predicted tertiary structure to PDB 4kfcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kfcA chr1 CDS 3194166 3195548 . - . ID=CDS1;locus_tag=Rv2885c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3195545 3196432 . - . ID=CDS1;locus_tag=Rv2886c;product=Probable resolvase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3196431 3196850 . + . ID=CDS1;locus_tag=Rv2887;product=Probable transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins, Required for imidazo[1,2-a]pyridine-4-carbonitrile-based agent, MP-III-71 susceptibility using complementation. [PMID: 26303802], possibly of the MarR (multiple antibiotic resistance repressor) family. [PMID: 26303802], Mutation of Rv2887 observed to increase expression of Rv0560c, a methyltransferase that N-methylates pyrido-benzimidazole, an antibacterial agent, abolishing its activity and conferring resistance. [PMID: 28106797];Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1z91A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z91A,Ontology_term=0044212/note:identified by similarity of predicted tertiary structure to PDB 1z91A,1jgsA,3deuA,2nnnA,3zplA,3f3xA,2fbkA,4fhtA,2fbiA,3zmdA,2fbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z91A,1jgsA,3deuA,2nnnA,3zplA,3f3xA,2fbkA,4fhtA,2fbiA,3zmdA,2fbhA,Ontology_term=0071236/note:identified by similarity of predicted tertiary structure to PDB 1jgsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jgsA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3fm5B,2fbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fm5B,2fbhA,Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3e6mD,1z91A,2fbkA,3f3xA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,4b8xA,2pexB,3zplA,4fx0A,2nnnA,3bpxA,4fhtA,2fbiA,3zmdA,3s2wA,2fbhA,5aipA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e6mD,1z91A,2fbkA,3f3xA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,4b8xA,2pexB,3zplA,4fx0A,2nnnA,3bpxA,4fhtA,2fbiA,3zmdA,3s2wA,2fbhA,5aipA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4fx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4fx0A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3e6mD,1z91A,2fbkA,3f3xA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,4b8xA,2pexB,3zplA,4fx0A,2nnnA,3bpxA,4fhtA,2fbiA,3zmdA,3s2wA,2fbhA,5aipA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e6mD,1z91A,2fbkA,3f3xA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,4b8xA,2pexB,3zplA,4fx0A,2nnnA,3bpxA,4fhtA,2fbiA,3zmdA,3s2wA,2fbhA,5aipA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 1jgsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jgsA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 3e6mD,1z91A,2fbkA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,2pexB,3zplA,4fx0A,2nnnA,4fhtA,2fbiA,3zmdA,2fbhA,5aipA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e6mD,1z91A,2fbkA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,2pexB,3zplA,4fx0A,2nnnA,4fhtA,2fbiA,3zmdA,2fbhA,5aipA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1jgsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jgsA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3e6mD,1z91A,2fbkA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,2pexB,3zplA,4fx0A,2nnnA,4fhtA,2fbiA,3zmdA,2fbhA,5aipA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e6mD,1z91A,2fbkA,3cdhB,3boqB,1jgsA,3fm5B,3deuA,2pexB,3zplA,4fx0A,2nnnA,4fhtA,2fbiA,3zmdA,2fbhA,5aipA,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 3deuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3deuA,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 1jgsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jgsA,Ontology_term=0045892/note:identified by similarity of predicted tertiary structure to PDB 2fbiA,5aipA,1jgsA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fbiA,5aipA,1jgsA,Ontology_term=0010124/note:identified by similarity of predicted tertiary structure to PDB 2fbiA,5aipA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fbiA,5aipA chr1 CDS 3196864 3198285 . - . ID=CDS1;locus_tag=Rv2888c;product=Probable amidase AmiC (aminohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3198292 3199107 . - . ID=CDS1;locus_tag=Rv2889c;product=Probable elongation factor Tsf (EF-ts);note=FunctionalCategory: information pathways chr1 CDS 3199119 3199982 . - . ID=CDS1;locus_tag=Rv2890c;product=30S ribosomal protein S2 RpsB;note=FunctionalCategory: information pathways chr1 CDS 3200266 3201015 . + . ID=CDS1;locus_tag=Rv2891;product=putative metalloendopeptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.24.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4lxcA,3it7A,1qwyA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016151/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0008237/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3it7A,1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3it7A,1qwyA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0004222/note:identified by similarity of predicted tertiary structure to PDB 3it7A,1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3it7A,1qwyA,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0009405/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0050897/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0043171/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1qwyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qwyA chr1 CDS 3200794 3202020 . - . ID=CDS1;locus_tag=Rv2892c;gene=PPE45;product=PPE family protein PPE45;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 3202420 3203397 . + . ID=CDS1;locus_tag=Rv2893;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3203394 3204290 . - . ID=CDS1;locus_tag=Rv2894c;product=Probable integrase/recombinase XerC;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3204381 3205232 . - . ID=CDS1;locus_tag=Rv2895c;product=Possible mycobactin utilization protein ViuB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3205265 3206434 . - . ID=CDS1;locus_tag=Rv2896c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3206431 3207942 . - . ID=CDS1;locus_tag=Rv2897c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3207942 3208328 . - . ID=CDS1;locus_tag=Rv2898c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, structurally similar to solved protein of unknown function UPF0102, identified by similarity of predicted tertiary structure to PDB 3fovA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fovA chr1 CDS 3208576 3209406 . - . ID=CDS1;locus_tag=Rv2899c;gene=fdhD;product=Possible FdhD protein homolog/putative sulfurtransferase/putative transport protein;note=FunctionalCategory: intermediary metabolism and respiration;EC_number=2.8.1.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,2pw9D2,4pdeA2,2pw9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,2pw9D2,4pdeA2,2pw9D,Ontology_term=0006777/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,2pw9D2,4pdeA2,2pw9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,2pw9D2,4pdeA2,2pw9D,Ontology_term=0043546/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,4pdeA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,4pdeA2,Ontology_term=0016783/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,2pw9D2,4pdeA2,2pw9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,2pw9D2,4pdeA2,2pw9D,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,4pdeA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,4pdeA2,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,2pw9D2,4pdeA2,2pw9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,2pw9D2,4pdeA2,2pw9D,Ontology_term=0097163/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,2pw9D2,4pdeA2,2pw9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,2pw9D2,4pdeA2,2pw9D,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,2pw9D2,4pdeA2,2pw9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,2pw9D2,4pdeA2,2pw9D,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,4pdeA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,4pdeA2,Ontology_term=0043085/note:identified by similarity of predicted tertiary structure to PDB 4pdeA,4pdeA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pdeA,4pdeA2 chr1 CDS 3209406 3211745 . - . ID=CDS1;locus_tag=Rv2900c;product=Possible formate dehydrogenase H FdhF (formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide) (formate dehydrogenase-H alpha subunit) (FDH-H);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3211803 3212108 . - . ID=CDS1;locus_tag=Rv2901c;product=;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3212162 3212956 . - . ID=CDS1;locus_tag=Rv2902c;product=Probable ribonuclease HII protein RnhB (RNase HII);note=FunctionalCategory: information pathways chr1 CDS 3212970 3213854 . - . ID=CDS1;locus_tag=Rv2903c;product=Probable signal peptidase I LepB (SPASE I) (leader peptidase I).;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3213912 3214253 . - . ID=CDS1;locus_tag=Rv2904c;product=50S ribosomal protein L19 RplS;note=FunctionalCategory: information pathways chr1 CDS 3214628 3215572 . + . ID=CDS1;locus_tag=Rv2905;product=Probable conserved alanine rich lipoprotein LppW;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3215665 3216357 . - . ID=CDS1;locus_tag=Rv2906c;product=Probable tRNA (guanine-N1)-methyltransferase TrmD (M1G-methyltransferase) (tRNA [GM37] methyltransferase);note=FunctionalCategory: information pathways chr1 CDS 3216361 3216891 . - . ID=CDS1;locus_tag=Rv2907c;product=Probable 16S rRNA processing protein RimM;note=FunctionalCategory: information pathways chr1 CDS 3216905 3217147 . - . ID=CDS1;locus_tag=Rv2908c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3217155 3217643 . - . ID=CDS1;locus_tag=Rv2909c;product=30S ribosomal protein S16 RpsP;note=FunctionalCategory: information pathways chr1 CDS 3217827 3218270 . - . ID=CDS1;locus_tag=Rv2910c;product=putative lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4l8oA,6stdA/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3a76A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 3a76A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a76A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 4l8oA,6stdA,3a76A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l8oA,6stdA,3a76A,Ontology_term=0009636/note:identified by similarity of predicted tertiary structure to PDB 3a76A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3a76A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 6stdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:6stdA,Ontology_term=0006582/note:identified by similarity of predicted tertiary structure to PDB 6stdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:6stdA,Ontology_term=0030411/note:identified by similarity of predicted tertiary structure to PDB 6stdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:6stdA,Ontology_term=0042438/note:identified by similarity of predicted tertiary structure to PDB 6stdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:6stdA,Ontology_term=0033988/note:identified by similarity of predicted tertiary structure to PDB 4l8oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l8oA,Ontology_term=0005768/note:identified by similarity of predicted tertiary structure to PDB 6stdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:6stdA chr1 CDS 3218339 3219214 . + . ID=CDS1;locus_tag=Rv2911;product=Probable penicillin-binding protein DacB2 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3219274 3219861 . - . ID=CDS1;locus_tag=Rv2912c;product=Probable transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3219863 3221698 . - . ID=CDS1;locus_tag=Rv2913c;product=Possible D-amino acid aminohydrolase (D-amino acid hydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3221767 3223524 . - . ID=CDS1;locus_tag=Rv2914c;product=Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase);note=FunctionalCategory: regulatory proteins chr1 CDS 3223568 3224680 . - . ID=CDS1;locus_tag=Rv2915c;product=putative metal-dependent amidohydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.13.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4c5yA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1v4yA,3giqA,4c5yA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016805/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0102009/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4c5yA,1v4yA,3giqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,1v4yA,3giqA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4c5yA,1v4yA,3giqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,1v4yA,3giqA,Ontology_term=1900817/note:identified by similarity of predicted tertiary structure to PDB 4c5yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,Ontology_term=0047421/note:identified by similarity of predicted tertiary structure to PDB 3giqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3giqA,Ontology_term=0047420/note:identified by similarity of predicted tertiary structure to PDB 1v4yA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1v4yA,Ontology_term=0016810/note:identified by similarity of predicted tertiary structure to PDB 4c5yA,1v4yA,3giqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4c5yA,1v4yA,3giqA chr1 CDS 3224708 3226285 . - . ID=CDS1;locus_tag=Rv2916c;gene=ffh;product=Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein)/putative GTPase;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.6.5.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0005786/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0030942/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0003924/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0042493/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0006614/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0045047/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0030529/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0019003/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0008312/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0006617/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0048500/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0043021/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0008144/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0006616/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 2j37W/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j37W chr1 CDS 3226363 3228243 . + . ID=CDS1;locus_tag=Rv2917;product=Conserved hypothetical alanine and arginine rich protein;Experiment=DESCRIPTION: RNA sequencing [PMID: 28659881]/note:FunctionalCategory: conserved hypotheticals/note:transcribed in LTBI patients [PMID: 28659881] chr1 CDS 3228254 3230680 . - . ID=CDS1;locus_tag=Rv2918c;product=Probable [protein-PII] uridylyltransferase GlnD (PII uridylyl- transferase) (uridylyl removing enzyme) (UTASE);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3230738 3231076 . - . ID=CDS1;locus_tag=Rv2919c;product=Probable nitrogen regulatory protein P-II GlnB;note=FunctionalCategory: regulatory proteins chr1 CDS 3231073 3232506 . - . ID=CDS1;locus_tag=Rv2920c;product=Probable ammonium-transport integral membrane protein Amt;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3232871 3234139 . - . ID=CDS1;locus_tag=Rv2921c;product=Probable cell division protein FtsY (SRP receptor) (signal recognition particle receptor);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3234189 3237806 . - . ID=CDS1;locus_tag=Rv2922c;product=Probable chromosome partition protein Smc;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3237818 3238099 . - . ID=CDS1;locus_tag=Rv2922A;product=Probable acylphosphatase AcyP (acylphosphate phosphohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3238086 3238499 . - . ID=CDS1;locus_tag=Rv2923c;gene=osmC;product=probable Osmotically induced bacterial protein C (OsmC, a probable peroxide reductase);Experiment=DESCRIPTION:protein purification, southern hybridization, overexpression, enzymatic assays [PMID: 22088319]/note:FunctionalCategory: conserved hypotheticals/note:probably protects against organic hydroperoxide stress [PMID: 22088319];EC_number=1.11.1.15 chr1 CDS 3238601 3239470 . - . ID=CDS1;locus_tag=Rv2924c;product=Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase);note=FunctionalCategory: information pathways chr1 CDS 3239829 3240551 . - . ID=CDS1;locus_tag=Rv2925c;product=Probable ribonuclease III Rnc (RNase III);note=FunctionalCategory: information pathways chr1 CDS 3240548 3241171 . - . ID=CDS1;locus_tag=Rv2926c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3241222 3241959 . - . ID=CDS1;locus_tag=Rv2927c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3242198 3242983 . + . ID=CDS1;locus_tag=Rv2928;product=Probable thioesterase TesA;note=FunctionalCategory: lipid metabolism chr1 CDS 3242970 3243281 . + . ID=CDS1;locus_tag=Rv2929;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3243697 3245448 . + . ID=CDS1;locus_tag=Rv2930;product=Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3245445 3251075 . + . ID=CDS1;locus_tag=Rv2931;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsA;note=FunctionalCategory: lipid metabolism chr1 CDS 3251072 3255688 . + . ID=CDS1;locus_tag=Rv2932;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsB;note=FunctionalCategory: lipid metabolism chr1 CDS 3255685 3262251 . + . ID=CDS1;locus_tag=Rv2933;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsC;note=FunctionalCategory: lipid metabolism chr1 CDS 3262248 3267731 . + . ID=CDS1;locus_tag=Rv2934;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsD;note=FunctionalCategory: lipid metabolism chr1 CDS 3267737 3272203 . + . ID=CDS1;locus_tag=Rv2935;product=Phenolpthiocerol synthesis type-I polyketide synthase PpsE;note=FunctionalCategory: lipid metabolism chr1 CDS 3272214 3273209 . + . ID=CDS1;locus_tag=Rv2936;product=Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3273206 3274075 . + . ID=CDS1;locus_tag=Rv2937;product=Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3274072 3274902 . + . ID=CDS1;locus_tag=Rv2938;product=Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3274949 3276217 . + . ID=CDS1;locus_tag=Rv2939;product=Possible conserved polyketide synthase associated protein PapA5;note=FunctionalCategory: lipid metabolism chr1 CDS 3276380 3282715 . - . ID=CDS1;locus_tag=Rv2940c;product=Probable multifunctional mycocerosic acid synthase membrane-associated Mas;note=FunctionalCategory: lipid metabolism chr1 CDS 3283335 3285077 . + . ID=CDS1;locus_tag=Rv2941;product=Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3285070 3287832 . + . ID=CDS1;locus_tag=Rv2942;product=Conserved transmembrane transport protein MmpL7;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3288464 3289705 . + . ID=CDS1;locus_tag=Rv2943;product=Probable transposase for insertion sequence element IS1533;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3289705 3290235 . + . ID=CDS1;locus_tag=Rv2943A;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3289790 3290506 . + . ID=CDS1;locus_tag=Rv2944;product=Possible transposase for insertion sequence element IS1533;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3290624 3291325 . - . ID=CDS1;locus_tag=Rv2945c;product=Probable conserved lipoprotein LppX;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3291503 3296353 . - . ID=CDS1;locus_tag=Rv2946c;product=Probable polyketide synthase Pks1;note=FunctionalCategory: lipid metabolism chr1 CDS 3296350 3297840 . - . ID=CDS1;locus_tag=Rv2947c;product=Probable polyketide synthase Pks15;note=FunctionalCategory: lipid metabolism chr1 CDS 3297837 3299954 . - . ID=CDS1;locus_tag=Rv2948c;product=P-hydroxybenzoyl-AMP ligase FadD22;note=FunctionalCategory: lipid metabolism chr1 CDS 3299971 3300570 . - . ID=CDS1;locus_tag=Rv2949c;product=Chorismate pyruvate lyase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3300596 3302455 . - . ID=CDS1;locus_tag=Rv2950c;product=Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3303103 3304248 . - . ID=CDS1;locus_tag=Rv2951c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3304441 3305253 . + . ID=CDS1;locus_tag=Rv2952;product=Possible methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3305279 3306535 . + . ID=CDS1;locus_tag=Rv2953;product=Enoyl reductase;note=FunctionalCategory: lipid metabolism chr1 CDS 3306666 3307391 . - . ID=CDS1;locus_tag=Rv2954c;product=Probable Methyltransferase /probable methyltransferase;Experiment=DESCRIPTION:gene disruption, MALDI-TOF mass spectrometry, Nuclear Magnetic Resonance (NMR) Spectroscopy [PMID: 23536839]/note:FunctionalCategory: conserved hypotheticals/note:Catalyzes the O-methylation of position 3 of the fucosyl residue of phenolic glycolipids [PMID: 23536839];EC_number=2.1.1.-,EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4iv0A,5kn4A,2gluA,4qnuA,4p7cA,4kdcA,3vc1A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0002098/note:identified by similarity of predicted tertiary structure to PDB 4qnuA,4p7cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qnuA,4p7cA,Ontology_term=0008689/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4iv0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,Ontology_term=0008169/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 4iv0A,5kn4A,2gluA,4kdcA,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,5kn4A,2gluA,4kdcA,3vc1A,Ontology_term=0006744/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 5kn4A,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5kn4A,3vc1A,Ontology_term=0042214/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0042538/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=0008425/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=0016765/note:identified by similarity of predicted tertiary structure to PDB 4qnuA,4p7cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qnuA,4p7cA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4iv0A,5kn4A,2gluA,4qnuA,4p7cA,4kdcA,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,5kn4A,2gluA,4qnuA,4p7cA,4kdcA,3vc1A,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 4iv0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 4qnuA,4p7cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4qnuA,4p7cA,Ontology_term=0008757/note:identified by similarity of predicted tertiary structure to PDB 3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vc1A,Ontology_term=0043431/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=0061542/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2gluA,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2gluA,3vc1A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 4iv0A,5kn4A,2gluA,4kdcA,3vc1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,5kn4A,2gluA,4kdcA,3vc1A,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 4iv0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4iv0A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA,Ontology_term=1901611/note:identified by similarity of predicted tertiary structure to PDB 4kdcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kdcA chr1 CDS 3307580 3308545 . - . ID=CDS1;locus_tag=Rv2955c;product=Probable Methyltransferase;Experiment=DESCRIPTION:gene disruption, MALDI-TOF mass spectrometry, Nuclear Magnetic Resonance (NMR) Spectroscopy [PMID: 23536839]/note:FunctionalCategory: conserved hypotheticals/note:Catalyzes the O-methylation of position 4 of the fucosyl residue of phenolic glycolipids;EC_number=2.1.1.- chr1 CDS 3308668 3309399 . + . ID=CDS1;locus_tag=Rv2956;product=probable S-adenosylmethionine-dependent methyltransferase;Experiment=DESCRIPTION: gene disruption, MALDI-TOF Mass Spectrometry, NMR spectrometry [PMID: 23536839]/note:FunctionalCategory: conserved hypotheticals/note:Catalyzes the O-methylation of position 2 of the fucosyl residue of phenolic glycolipids;EC_number=2.1.1.12 chr1 CDS 3309470 3310297 . + . ID=CDS1;locus_tag=Rv2957;product=Possible glycosyl transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3310714 3312000 . - . ID=CDS1;locus_tag=Rv2958c;product=Possible glycosyl transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3312101 3312838 . - . ID=CDS1;locus_tag=Rv2959c;product=Possible methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3312953 3313201 . - . ID=CDS1;locus_tag=Rv2960c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3313283 3313672 . + . ID=CDS1;locus_tag=Rv2961;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3313773 3315122 . - . ID=CDS1;locus_tag=Rv2962c;product=Possible glycosyl transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3315236 3316456 . + . ID=CDS1;locus_tag=Rv2963;product=Probable integral membrane protein/putative ion transporter;note=FunctionalCategory: cell wall and cell processes, up regulated on mmpL3 deletion in M. tuberculosis [PMID: 28240248], Induced by copper [PMID: 21166899], potential Ca(2+)/cation antiporter, identified by similarity of predicted tertiary structure to PDB 4kppA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kppA chr1 CDS 3316529 3317461 . + . ID=CDS1;locus_tag=Rv2964;product=Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3318330 3318815 . - . ID=CDS1;locus_tag=Rv2965c;product=Probable phosphopantetheine adenylyltransferase KdtB (pantetheine- phosphate adenylyltransferase) (PPAT) (dephospho-CoA pyrophosphorylase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3318901 3319467 . - . ID=CDS1;locus_tag=Rv2966c;product=Possible methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3319663 3323046 . - . ID=CDS1;locus_tag=Rv2967c;product=Probable pyruvate carboxylase Pca (pyruvic carboxylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3323071 3323703 . - . ID=CDS1;locus_tag=Rv2968c;product=Putative Vitamin K epoxide reductase;note=FunctionalCategory: cell wall and cell processes, Homologous to human vitamin K epoxide reductase (VKOR) [PMID: 20018758];EC_number=1.17.4.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3kp9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3kp9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kp9A,Ontology_term=0048038/note:identified by similarity of predicted tertiary structure to PDB 3kp9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kp9A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 3kp9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kp9A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3kp9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kp9A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3kp9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kp9A chr1 CDS 3323709 3324476 . - . ID=CDS1;locus_tag=Rv2969c;product=Periplasmic disulfide-bonding forming (Dsb) Enzyme;Experiment=DESCRIPTION:Protein expression and purification, Crystallization and structure determination, Insulin-reduction assay, Peptide-oxidation assay [PMID: 24100317]/note:FunctionalCategory: cell wall and cell processes/note:composes a canonical DsbA fold comprising a thioredoxin domain with an embedded helical domain [PMID: 24100317]/note:localizes on the bacillus surface [PMID: 18539140] chr1 CDS 3324573 3325703 . - . ID=CDS1;locus_tag=Rv2970c;product=Probable lipase/esterase LipN;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3325934 3326104 . + . ID=CDS1;locus_tag=Rv2970A;product=Probable oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.1.1.21 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2vdgA,3o3rA,4hbkA,2pdmA,3krbA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.1.1.346 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1m9hA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.3.1.3 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3g1rA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.1.1.2 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2vdgA,3o3rA,4hbkA,2pdmA,3krbA,1vp5A,3up8A,3fx4A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.1.1.188 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006633/note:identified by similarity of predicted tertiary structure to PDB 1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,4fziA,4f40A,Ontology_term=0008106/note:identified by similarity of predicted tertiary structure to PDB 3fx4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fx4A,Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,4fziA,4f40A,Ontology_term=0004032/note:identified by similarity of predicted tertiary structure to PDB 2vdgA,3o3rA,4hbkA,2pdmA,3krbA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vdgA,3o3rA,4hbkA,2pdmA,3krbA,Ontology_term=0046427/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0043795/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0042629/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 3o3rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o3rA,Ontology_term=0009414/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0060135/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0043220/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0001894/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2vdgA,3o3rA,4hbkA,2pdmA,3krbA,1m9hA,3g1rA,1vp5A,3up8A,3fx4A,1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vdgA,3o3rA,4hbkA,2pdmA,3krbA,1m9hA,3g1rA,1vp5A,3up8A,3fx4A,1vbjA,4fziA,4f40A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3o3rA,2pdmA,1m9hA,3g1rA,1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o3rA,2pdmA,1m9hA,3g1rA,1vbjA,4fziA,4f40A,Ontology_term=0044597/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0097066/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0003091/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0048661/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0044598/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0031098/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3krbA,1vp5A,1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3krbA,1vp5A,1vbjA,4fziA,4f40A,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0043066/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0005615/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0008202/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0033010/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0004033/note:identified by similarity of predicted tertiary structure to PDB 3o3rA,2pdmA,3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3o3rA,2pdmA,3g1rA,Ontology_term=0048471/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0047787/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0072001/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0097454/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=1901653/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0019853/note:identified by similarity of predicted tertiary structure to PDB 1m9hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1m9hA,Ontology_term=0006700/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0006707/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3g1rA,1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,1vbjA,4fziA,4f40A,Ontology_term=0018931/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0007586/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0070301/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 2pdmA,3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,3g1rA,Ontology_term=0046370/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0047017/note:identified by similarity of predicted tertiary structure to PDB 1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,4fziA,4f40A,Ontology_term=0001516/note:identified by similarity of predicted tertiary structure to PDB 1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,4fziA,4f40A,Ontology_term=0006950/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0008209/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0005496/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0008207/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0072061/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0010033/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2vdgA,3o3rA,4hbkA,2pdmA,3krbA,1m9hA,3g1rA,1vp5A,3up8A,3fx4A,1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vdgA,3o3rA,4hbkA,2pdmA,3krbA,1m9hA,3g1rA,1vp5A,3up8A,3fx4A,1vbjA,4fziA,4f40A,Ontology_term=0009055/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0036131/note:identified by similarity of predicted tertiary structure to PDB 1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,4fziA,4f40A,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0097238/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0045290/note:identified by similarity of predicted tertiary structure to PDB 1vbjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,Ontology_term=0005996/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2pdmA,3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,3g1rA,Ontology_term=0032838/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0042415/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0006693/note:identified by similarity of predicted tertiary structure to PDB 1vbjA,4fziA,4f40A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,4fziA,4f40A,Ontology_term=0035809/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0019571/note:identified by similarity of predicted tertiary structure to PDB 1vbjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vbjA,Ontology_term=0050580/note:identified by similarity of predicted tertiary structure to PDB 3up8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3up8A,Ontology_term=0006061/note:identified by similarity of predicted tertiary structure to PDB 2pdmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pdmA,Ontology_term=0006699/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA,Ontology_term=0030573/note:identified by similarity of predicted tertiary structure to PDB 3g1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3g1rA chr1 CDS 3326101 3326949 . + . ID=CDS1;locus_tag=Rv2971;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3327023 3327736 . - . ID=CDS1;locus_tag=Rv2972c;product=Possible conserved membrane or exported protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3327733 3329946 . - . ID=CDS1;locus_tag=Rv2973c;product=Probable ATP-dependent DNA helicase RecG;note=FunctionalCategory: information pathways chr1 CDS 3329949 3331361 . - . ID=CDS1;locus_tag=Rv2974c;product=Conserved hypothetical alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3331358 3331612 . - . ID=CDS1;locus_tag=Rv2975c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3332071 3332754 . - . ID=CDS1;locus_tag=Rv2976c;product=Probable uracil-DNA glycosylase Ung (UDG);note=FunctionalCategory: information pathways chr1 CDS 3332787 3333788 . - . ID=CDS1;locus_tag=Rv2977c;product=Probable thiamine-monophosphate kinase ThiL (thiamine-phosphate kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3333785 3335164 . - . ID=CDS1;locus_tag=Rv2978c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3335164 3335748 . - . ID=CDS1;locus_tag=Rv2979c;product=Probable resolvase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3335960 3336505 . + . ID=CDS1;locus_tag=Rv2980;product=Possible conserved secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3336796 3337917 . - . ID=CDS1;locus_tag=Rv2981c;product=Probable D-alanine--D-alanine ligase DdlA (D-alanylalanine synthetase) (D-ala-D-ala ligase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3337995 3338999 . - . ID=CDS1;locus_tag=Rv2982c;product=Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase);note=FunctionalCategory: lipid metabolism chr1 CDS 3339118 3339762 . + . ID=CDS1;locus_tag=Rv2983;product=putative nucleotidyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.7.-;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2i5eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2i5eA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2i5eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2i5eA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 2i5eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2i5eA,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 2i5eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2i5eA chr1 CDS 3339854 3342082 . + . ID=CDS1;locus_tag=Rv2984;product=Polyphosphate kinase PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3342165 3343118 . + . ID=CDS1;locus_tag=Rv2985;product=Possible hydrolase MutT1;note=FunctionalCategory: information pathways chr1 CDS 3343176 3343820 . - . ID=CDS1;locus_tag=Rv2986c;product=DNA-binding protein HU homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein);note=FunctionalCategory: information pathways chr1 CDS 3344033 3344629 . - . ID=CDS1;locus_tag=Rv2987c;product=Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3344654 3346075 . - . ID=CDS1;locus_tag=Rv2988c;product=Probable 3-isopropylmalate dehydratase (large subunit) LeuC (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3346147 3346848 . + . ID=CDS1;locus_tag=Rv2989;product=IclR family transcriptional factor;Experiment=DESCRIPTION: Gene expression, Real-time quantitative PCR, Catalase activity assay. [DOI:10.1039/C6RA07733A ]/note:FunctionalCategory: regulatory proteins/note:Involved in isoniazid tolerance by regulating the expression of catalase encoding gene katG. [DOI:10.1039/C6RA07733A ]/note:Down regulated in otsB2 mutant strain (trehalose-6-phosphate phosphatase silenced strain) [PMID: 27936238] chr1 CDS 3346859 3347719 . - . ID=CDS1;locus_tag=Rv2990c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Down regulated in otsB2 mutant strain (trehalose-6-phosphate phosphatase silenced strain) [PMID: 27936238] chr1 CDS 3347982 3348473 . + . ID=CDS1;locus_tag=Rv2991;product=probable flavin/deazaflavin oxidoreductase/probable flavin/deazaflavin oxidoreductase/putative oxidase;Experiment=DESCRIPTION:crystallography, ligand binding affinity assay to coenzyme F420, flavin mononucleotide and flavin adenine dinucleotide [PMID: 26434506]/note:FunctionalCategory: conserved hypotheticals/note:Predicted to be F420 dependent;EC_number=1.5.8.-,EC_number=1.4.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4zkyA,1y30A,2a2jA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004733/note:identified by similarity of predicted tertiary structure to PDB 2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a2jA,Ontology_term=0030170/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0071949/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1y30A,2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,2a2jA,Ontology_term=0010181/note:identified by similarity of predicted tertiary structure to PDB 1y30A,2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,2a2jA,Ontology_term=0042823/note:identified by similarity of predicted tertiary structure to PDB 2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a2jA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1y30A,2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,2a2jA,Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 4zkyA,1y30A,2a2jA/inference:ab initio prediction:I-TASSER:5.1/note:potential Ca(2+)/cation antiporter/note:identified by similarity of predicted tertiary structure to PDB 4kppA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4kppA/inference:alignment:TM-align:PDB:4zkyA,1y30A,2a2jA,Ontology_term=0008615/note:identified by similarity of predicted tertiary structure to PDB 2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a2jA,Ontology_term=0016899/note:identified by similarity of predicted tertiary structure to PDB 2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a2jA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1y30A,2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,2a2jA,Ontology_term=0070967/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0016638/note:identified by similarity of predicted tertiary structure to PDB 2a2jA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a2jA,Ontology_term=0042816/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A,Ontology_term=0070402/note:identified by similarity of predicted tertiary structure to PDB 1y30A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1y30A chr1 CDS 3348805 3350277 . - . ID=CDS1;locus_tag=Rv2992c;product=Glutamyl-tRNA synthetase GltS (glutamate--tRNA ligase) (glutamyl-tRNA synthase) (GLURS);note=FunctionalCategory: information pathways chr1 CDS 3350274 3350993 . - . ID=CDS1;locus_tag=Rv2993c;product=Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3351269 3352606 . + . ID=CDS1;locus_tag=Rv2994;product=Antigen/putative phosphate transporter;Experiment=DESCRIPTION:Protein purification and expression, mouse recombinant protein immunization, ELISA, western blot [PMID: 28217905]/note:FunctionalCategory: cell wall and cell processes/note:Possible fluoroquinolone efflux protein. [PMID: 12520088]/note:Probable conserved integral membrane protein [TubercuList]/note:potential glycerol-3-phosphate transporter/note:identified by similarity of predicted tertiary structure to PDB 1pw4A, 4j05A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pw4A, 4j05A chr1 CDS 3352458 3353468 . - . ID=CDS1;locus_tag=Rv2995c;product=Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3353483 3355069 . - . ID=CDS1;locus_tag=Rv2996c;product=Probable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3355099 3356541 . + . ID=CDS1;locus_tag=Rv2997;product=Possible alanine rich dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3356815 3357276 . + . ID=CDS1;locus_tag=Rv2998;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3357225 3357428 . - . ID=CDS1;locus_tag=Rv2998A;product=putative phosphorelay sensor kinase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.-.-;Ontology_term=0000155/note:identified by similarity of predicted tertiary structure to PDB 3zrwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3zrwA,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4gn0A,3zrwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gn0A,3zrwA,Ontology_term=0007165/note:identified by similarity of predicted tertiary structure to PDB 4gn0A,3zrwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gn0A,3zrwA,Ontology_term=0004871/note:identified by similarity of predicted tertiary structure to PDB 4gn0A,3zrwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4gn0A,3zrwA chr1 CDS 3357602 3358567 . + . ID=CDS1;locus_tag=Rv2999;product=Probable conserved lipoprotein LppY;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3358612 3359271 . + . ID=CDS1;locus_tag=Rv3000;product=Probable ABC transporter;note=FunctionalCategory: cell wall and cell processes;EC_number=3.4.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4ry2A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016887/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0008234/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0042626/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0055085/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0043213/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A,Ontology_term=0022885/note:identified by similarity of predicted tertiary structure to PDB 4ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ry2A chr1 CDS 3359585 3360586 . - . ID=CDS1;locus_tag=Rv3001c;product=Probable KETOL-acid reductoisomerase IlvC (acetohydroxy-acid isomeroreductase) (alpha-keto-beta-hydroxylacil reductoisomerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3360624 3361130 . - . ID=CDS1;locus_tag=Rv3002c;product=Probable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) (AHAS) (ALS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3361130 3362986 . - . ID=CDS1;locus_tag=Rv3003c;product=Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3363348 3363686 . + . ID=CDS1;locus_tag=Rv3004;product=Low molecular weight protein antigen 6 (CFP-6);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3363693 3364532 . - . ID=CDS1;locus_tag=Rv3005c;gene=doxX;product=Probable membrane oxidoreductase component (MRC) DoxX;note=FunctionalCategory: conserved hypotheticals, forms 3-component membrane oxidoreductase complex with SseA and SodA that involved in oxidative stress response via maintenance of thiol homeostasis [PMID: 26067605];Experiment=DESCRIPTION:KO mutant in murine macrophages, co-Immunoprecipitation, thiosulfate oxidation assay [PMID: 26067605] chr1 CDS 3364709 3365830 . + . ID=CDS1;locus_tag=Rv3006;product=Probable conserved lipoprotein LppZ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3365836 3366450 . - . ID=CDS1;locus_tag=Rv3007c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3366644 3367267 . + . ID=CDS1;locus_tag=Rv3008;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3367264 3368793 . - . ID=CDS1;locus_tag=Rv3009c;product=Probable glutamyl-tRNA(GLN) amidotransferase (subunit B) GatB (Glu-ADT subunit B);note=FunctionalCategory: information pathways chr1 CDS 3368823 3369854 . - . ID=CDS1;locus_tag=Rv3010c;product=Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3369950 3371434 . - . ID=CDS1;locus_tag=Rv3011c;product=Probable glutamyl-tRNA(GLN) amidotransferase (subunit A) GatA (Glu-ADT subunit A);note=FunctionalCategory: information pathways chr1 CDS 3371431 3371730 . - . ID=CDS1;locus_tag=Rv3012c;product=Probable glutamyl-tRNA(GLN) amidotransferase (subunit C) GatC (Glu-ADT subunit C);note=FunctionalCategory: information pathways chr1 CDS 3371815 3372471 . + . ID=CDS1;locus_tag=Rv3013;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3372545 3374620 . - . ID=CDS1;locus_tag=Rv3014c;product=DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]);note=FunctionalCategory: information pathways chr1 CDS 3374651 3375664 . - . ID=CDS1;locus_tag=Rv3015c;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0048046/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0008705/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A,Ontology_term=0010043/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0009651/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0003871/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0050667/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,Ontology_term=0009570/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0005777/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0005774/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A,Ontology_term=0046686/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A,Ontology_term=0005794/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0009506/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0009507/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0008652/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1xr2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0005507/note:identified by similarity of predicted tertiary structure to PDB 1u1uA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u1uA,Ontology_term=0009086/note:identified by similarity of predicted tertiary structure to PDB 1xr2B,1u1uA,2nq5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xr2B,1u1uA,2nq5A chr1 CDS 3375758 3376387 . + . ID=CDS1;locus_tag=Rv3016;product=Probable lipoprotein LpqA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3376490 3376852 . - . ID=CDS1;locus_tag=Rv3017c;product=ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3376939 3378243 . - . ID=CDS1;locus_tag=Rv3018c;gene=PPE46;product=T-cell antigen;Experiment=DESCRIPTION:Protein expression and purification, in vitro proliferation assay, cytokine assay, ELISPOT assay, flow cytometry, cytotoxic T lymphocyte assay [PMID: 18719176]/note:FunctionalCategory: PE/PPE/note:Associated with virulence in vivo, transposon insertion mutant of Rv3018c exhibited attenuated growth in macrophages [PMID: 10564470]/note:Contains IS element insertion site within an ORF [PMID: 22703188] chr1 CDS 3378329 3378415 . - . ID=CDS1;locus_tag=Rv3018A;gene=PE27A;product=PE family protein PE27A;Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938]/note:FunctionalCategory: PE/PPE/note:Located in the cell membrane [PMID: 21261938] chr1 CDS 3378711 3379001 . - . ID=CDS1;locus_tag=Rv3019c;product=Secreted ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3379036 3379329 . - . ID=CDS1;locus_tag=Rv3020c;product=ESAT-6 like protein EsxS;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3379376 3380452 . - . ID=CDS1;locus_tag=Rv3021c;gene=PPE47;product=PPE family protein PPE47;note=FunctionalCategory: PE/PPE chr1 CDS 3380440 3380682 . - . ID=CDS1;locus_tag=Rv3022c;gene=PPE48;product=PPE family protein PPE48/T-cell antigen;Experiment=DESCRIPTION:Ex-vivo interferon-gamma ELISPOT assay [PMID: 26277695]/note:Expressed in low oxygen conditions [PMID: 15207491]/note:FunctionalCategory: PE/PPE chr1 CDS 3380679 3380993 . - . ID=CDS1;locus_tag=Rv3022A;gene=PE29;product=PE family protein PE29;note=FunctionalCategory: PE/PPE, Duplicated from ESAT-6 (esx) gene cluster region 3 [PMID: 17105670] chr1 CDS 3381375 3382622 . - . ID=CDS1;locus_tag=Rv3023c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3382785 3383888 . - . ID=CDS1;locus_tag=Rv3024c;product=Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU;note=FunctionalCategory: information pathways chr1 CDS 3383885 3385066 . - . ID=CDS1;locus_tag=Rv3025c;product=Cysteine desulfurase IscS (NIFS protein homolog) (nitrogenase metalloclusters biosynthesis protein NIFS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3385163 3386077 . - . ID=CDS1;locus_tag=Rv3026c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3386074 3386919 . - . ID=CDS1;locus_tag=Rv3027c;product=GCN5-related N-acetyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3387075 3388031 . - . ID=CDS1;locus_tag=Rv3028c;product=Probable electron transfer flavoprotein (alpha-subunit) FixB (alpha-ETF) (electron transfer flavoprotein large subunit) (ETFLS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3388070 3388870 . - . ID=CDS1;locus_tag=Rv3029c;product=Probable electron transfer flavoprotein (beta-subunit) FixA (beta-ETF) (electron transfer flavoprotein small subunit) (ETFSS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3389101 3389925 . + . ID=CDS1;locus_tag=Rv3030;product=Conserved protein;Experiment=DESCRIPTION:disruption of M. smegmatis ortholog interrupted MGLP synthesis [PMID: 17640872], subsequent/note:FunctionalCategory: conserved hypotheticals/note:probably S-adenosyl-methionine-dependent[PMID:17640872],Experiment=questions whether coordinates match Rv3030 or not [PMID:22678749]/note:S-adenosyl-methionine-dependent-methyltransferase genes. [PMID: 17640872] chr1 CDS 3389922 3391502 . + . ID=CDS1;locus_tag=Rv3031;product=Conserved protein/Putative 1,4-alpha-glucan branching enzyme;note=FunctionalCategory: conserved hypotheticals;EC_number=2.4.1.18 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1ufaA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA,Ontology_term=0102752/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA,Ontology_term=0003844/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA,Ontology_term=0016757/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA,Ontology_term=0005978/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA,Ontology_term=0005977/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 1ufaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ufaA chr1 CDS 3391534 3392778 . + . ID=CDS1;locus_tag=Rv3032;product=Alpha (1->4) glucosyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3392812 3393201 . + . ID=CDS1;locus_tag=Rv3032A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3393380 3393928 . + . ID=CDS1;locus_tag=Rv3033;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3394019 3394756 . - . ID=CDS1;locus_tag=Rv3034c;product=Possible transferase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3395379 3396461 . + . ID=CDS1;locus_tag=Rv3035;product=Conserved protein/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0051205/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=1990063/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=0043165/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=0019867/note:identified by similarity of predicted tertiary structure to PDB 4pk1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=0009279/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=0071709/note:identified by similarity of predicted tertiary structure to PDB 4pk1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4pk1A,3p1lA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pk1A,3p1lA chr1 CDS 3396458 3397141 . - . ID=CDS1;locus_tag=Rv3036c;product=esterase;note=Probable cell-wall and cell membrane anchored, FunctionalCategory: cell wall and cell processes;Experiment=DESCRIPTION:Enzyme activity assay, Western blotting [PMID: 25224799];EC_number=3.1.-.- chr1 CDS 3397214 3398290 . - . ID=CDS1;locus_tag=Rv3037c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, S-adenosyl-methionine-dependent-methyltransferase genes. [PMID: 17640872] chr1 CDS 3398425 3399408 . - . ID=CDS1;locus_tag=Rv3038c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3399419 3400183 . - . ID=CDS1;locus_tag=Rv3039c;product=Probable enoyl-CoA hydratase EchA17 (crotonase) (unsaturated acyl-CoA hydratase) (enoyl hydrase);note=FunctionalCategory: lipid metabolism chr1 CDS 3400192 3401058 . - . ID=CDS1;locus_tag=Rv3040c;product=Conserved protein/putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3qsjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3qsjA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3qsjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3qsjA chr1 CDS 3401055 3401918 . - . ID=CDS1;locus_tag=Rv3041c;product=Probable conserved ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3401933 3403162 . - . ID=CDS1;locus_tag=Rv3042c;product=Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3403200 3404921 . - . ID=CDS1;locus_tag=Rv3043c;product=Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3405136 3406215 . + . ID=CDS1;locus_tag=Rv3044;product=Probable FEIII-dicitrate-binding periplasmic lipoprotein FecB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3406285 3407325 . + . ID=CDS1;locus_tag=Rv3045;product=Probable NADP-dependent alcohol dehydrogenase AdhC;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3407314 3407688 . - . ID=CDS1;locus_tag=Rv3046c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3408022 3408306 . - . ID=CDS1;locus_tag=Rv3047c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3408404 3409378 . - . ID=CDS1;locus_tag=Rv3048c;product=Ribonucleoside-diphosphate reductase (beta chain) NrdF2 (ribonucleotide reductase small subunit) (R2F protein);note=FunctionalCategory: information pathways chr1 CDS 3409509 3411083 . - . ID=CDS1;locus_tag=Rv3049c;product=Probable monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3411217 3411957 . - . ID=CDS1;locus_tag=Rv3050c;product=Probable transcriptional regulatory protein (probably AsnC-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3412085 3414166 . - . ID=CDS1;locus_tag=Rv3051c;product=Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein);note=FunctionalCategory: information pathways chr1 CDS 3414232 3414684 . - . ID=CDS1;locus_tag=Rv3052c;product=Probable NrdI protein;note=FunctionalCategory: information pathways chr1 CDS 3414719 3414958 . - . ID=CDS1;locus_tag=Rv3053c;product=Probable glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH;note=FunctionalCategory: information pathways chr1 CDS 3415435 3415989 . - . ID=CDS1;locus_tag=Rv3054c;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.7.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3w78A,3kegB,3gfrD,1tikA,4c0wA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006979/note:identified by similarity of predicted tertiary structure to PDB 1tikA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tikA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3w78A,3kegB,3gfrD,1tikA,4c0wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,3kegB,3gfrD,1tikA,4c0wA,Ontology_term=0052873/note:identified by similarity of predicted tertiary structure to PDB 3gfrD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gfrD,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3w78A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,Ontology_term=0016661/note:identified by similarity of predicted tertiary structure to PDB 3w78A,3kegB,1tikA,4c0wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,3kegB,1tikA,4c0wA,Ontology_term=0010181/note:identified by similarity of predicted tertiary structure to PDB 3w78A,3gfrD,1tikA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,3gfrD,1tikA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3gfrD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gfrD,Ontology_term=0016652/note:identified by similarity of predicted tertiary structure to PDB 3w78A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,Ontology_term=0008752/note:identified by similarity of predicted tertiary structure to PDB 3w78A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,Ontology_term=0050446/note:identified by similarity of predicted tertiary structure to PDB 1tikA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1tikA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3w78A,3kegB,3gfrD,1tikA,4c0wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,3kegB,3gfrD,1tikA,4c0wA,Ontology_term=0009055/note:identified by similarity of predicted tertiary structure to PDB 3w78A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w78A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3gfrD,1tikA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gfrD,1tikA,Ontology_term=0016655/note:identified by similarity of predicted tertiary structure to PDB 3kegB,1tikA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kegB,1tikA chr1 CDS 3416081 3416695 . + . ID=CDS1;locus_tag=Rv3055;product=Possible transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3416705 3417745 . + . ID=CDS1;locus_tag=Rv3056;product=Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed));note=FunctionalCategory: information pathways chr1 CDS 3417799 3418662 . - . ID=CDS1;locus_tag=Rv3057c;product=Probable short chain alcohol dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3418726 3419376 . - . ID=CDS1;locus_tag=Rv3058c;product=Possible transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3419492 3420970 . + . ID=CDS1;locus_tag=Rv3059;product=Probable cytochrome P450 136 Cyp136;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3421741 3423213 . - . ID=CDS1;locus_tag=Rv3060c;product=Probable transcriptional regulatory protein (probably GntR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3423262 3425427 . - . ID=CDS1;locus_tag=Rv3061c;product=Probable acyl-CoA dehydrogenase FadE22;note=FunctionalCategory: lipid metabolism chr1 CDS 3425584 3427107 . + . ID=CDS1;locus_tag=Rv3062;product=Probable ATP-dependent DNA ligase LigB (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase);note=FunctionalCategory: information pathways chr1 CDS 3427243 3429519 . + . ID=CDS1;locus_tag=Rv3063;product=Probable carbon starvation protein A homolog CstA;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3429825 3430250 . - . ID=CDS1;locus_tag=Rv3064c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3430387 3430710 . + . ID=CDS1;locus_tag=Rv3065;gene=mmr/emrE;product=Multidrug-transport efflux pump emrE/Probable multidrug transport protein;Experiment=DESCRIPTION:Gene knockout, Drug susceptibility (MIC) assays. [PMID: 22314527]/note:FunctionalCategory: cell wall and cell processes/note:active drug efflux pump [PMID: 22314527]/note:belongs to SMR transporter class [PMID: 22314527]/note:probably plays a major role in mediating the efflux of compounds in the pyrazolone chemical class [PMID: 22314527]/note:overexpressed under INH stress [PMID: 22314527]/note:identified by similarity of predicted tertiary structure to PDB 3b5dA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b5dA chr1 CDS 3430707 3431315 . + . ID=CDS1;locus_tag=Rv3066;product=Probable transcriptional regulatory protein (probably DeoR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3431428 3431838 . + . ID=CDS1;locus_tag=Rv3067;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3431979 3433622 . - . ID=CDS1;locus_tag=Rv3068c;product=Probable phosphoglucomutase PgmA (glucose phosphomutase) (PGM);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3433692 3434090 . + . ID=CDS1;locus_tag=Rv3069;product=Probable conserved transmembrane protein/putative inorganic anion transport protein;note=FunctionalCategory: cell wall and cell processes;Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0015103/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0034220/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0005887/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0015698/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A chr1 CDS 3434087 3434467 . + . ID=CDS1;locus_tag=Rv3070;product=Probable conserved integral membrane protein/putative inorganic anion transport protein;note=FunctionalCategory: cell wall and cell processes;Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0015103/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0034220/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0005887/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A,Ontology_term=0015698/note:identified by similarity of predicted tertiary structure to PDB 5a43A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a43A chr1 CDS 3434464 3435573 . + . ID=CDS1;locus_tag=Rv3071;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3435798 3436322 . - . ID=CDS1;locus_tag=Rv3072c;product=putative NAD(P)H monooxygenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.14.13.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3sdoA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004497/note:identified by similarity of predicted tertiary structure to PDB 3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sdoA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sdoA,Ontology_term=0016705/note:identified by similarity of predicted tertiary structure to PDB 3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sdoA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3sdoA chr1 CDS 3436329 3436685 . - . ID=CDS1;locus_tag=Rv3073c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3436779 3438053 . + . ID=CDS1;locus_tag=Rv3074;product=Probable hydrolase/endonuclease;Inference=ab initio prediction:Phyre2 [PMID: 27724857]/note:FunctionalCategory: conserved hypotheticals/note:Upregulated on mitomycin C treatment and treatment with the nitrosative agent diethylenetriamine nitric oxide [PMID: 27724857] chr1 CDS 3438050 3438973 . - . ID=CDS1;locus_tag=Rv3075c;product=Conserved protein/putative oxo-acid lyase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=4.1.3.-;Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,3qllA,1sgjA,4roqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,3qllA,1sgjA,4roqA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 1sgjA,3qllA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sgjA,3qllA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,3qllA,1sgjA,4roqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,3qllA,1sgjA,4roqA,Ontology_term=0006107/note:identified by similarity of predicted tertiary structure to PDB 1sgjA,3qllA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sgjA,3qllA,Ontology_term=0015977/note:identified by similarity of predicted tertiary structure to PDB 4l7zA,4l7zA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l7zA,4l7zA1,Ontology_term=0047777/note:identified by similarity of predicted tertiary structure to PDB 4l7zA,4l9yA,4l7zA1,4l9yA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l7zA,4l9yA,4l7zA1,4l9yA1,Ontology_term=0050083/note:identified by similarity of predicted tertiary structure to PDB 4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,4roqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,4roqA,Ontology_term=0043427/note:identified by similarity of predicted tertiary structure to PDB 4l7zA,4l7zA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l7zA,4l7zA1,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,3qllA,1sgjA,4roqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4l9yA,4roqA1,4l7zA,4l9yA1,4l7zA1,3qllA,1sgjA,4roqA chr1 CDS 3439072 3439548 . + . ID=CDS1;locus_tag=Rv3076;product=putative lyase/putative protein phosphatase inhibitor;note=FunctionalCategory: conserved hypotheticals;EC_number=4.-.-.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0009738/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0043086/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0080163/note:identified by similarity of predicted tertiary structure to PDB 3k3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3k3kA,Ontology_term=0004864/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0004872/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 5e46A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5e46A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3k3kA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3k3kA,Ontology_term=0010427/note:identified by similarity of predicted tertiary structure to PDB 3oquA,3k3kA,3kdhA,4n0gC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3oquA,3k3kA,3kdhA,4n0gC chr1 CDS 3439541 3441352 . + . ID=CDS1;locus_tag=Rv3077;product=Possible hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3441353 3441754 . + . ID=CDS1;locus_tag=Rv3078;product=Probable hydroxylaminobenzene mutase Hab;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3441770 3442597 . - . ID=CDS1;locus_tag=Rv3079c;product=Conserved protein/putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;Inference=ab initio prediction:I-TASSER:5.1;EC_number=1.14.14.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3fgcD,3fgcA,1nqkA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.5.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1z69A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.1.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3c8nA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.14.13.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3sdoA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004497/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,3sdoA,Ontology_term=0006730/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0046306/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0047646/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0019386/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0008218/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016705/note:identified by similarity of predicted tertiary structure to PDB 1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0008726/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0015948/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0045454/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rhcA,3fgcD,3fgcA,1nqkA,1z69A,3c8nA,3sdoA,Ontology_term=0052749/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016614/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0070967/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0018537/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A chr1 CDS 3442656 3445988 . - . ID=CDS1;locus_tag=Rv3080c;product=Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K);note=FunctionalCategory: regulatory proteins chr1 CDS 3446040 3447278 . + . ID=CDS1;locus_tag=Rv3081;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3447404 3448426 . - . ID=CDS1;locus_tag=Rv3082c;product=Virulence-regulating transcriptional regulator VirS (AraC/XylS family);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3448504 3449991 . + . ID=CDS1;locus_tag=Rv3083;product=Probable monooxygenase (hydroxylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3449997 3450923 . + . ID=CDS1;locus_tag=Rv3084;product=Probable acetyl-hydrolase/esterase LipR;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3450920 3451750 . + . ID=CDS1;locus_tag=Rv3085;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3451781 3452887 . + . ID=CDS1;locus_tag=Rv3086;product=Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3452925 3454343 . + . ID=CDS1;locus_tag=Rv3087;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 3454340 3455764 . + . ID=CDS1;locus_tag=Rv3088;product=Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4;note=FunctionalCategory: lipid metabolism chr1 CDS 3455761 3457272 . + . ID=CDS1;locus_tag=Rv3089;product=Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase);note=FunctionalCategory: lipid metabolism chr1 CDS 3458211 3459098 . + . ID=CDS1;locus_tag=Rv3090;product=Unknown alanine and valine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3459116 3460807 . + . ID=CDS1;locus_tag=Rv3091;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3460814 3461734 . - . ID=CDS1;locus_tag=Rv3092c;product=Probable conserved integral membrane protein/Putative membrane transport protein;note=FunctionalCategory: cell wall and cell processes, Expression significantly induced under Manganese limitation [PMID: 26337157], identified by similarity of predicted tertiary structure to PDB 5aymA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5aymA chr1 CDS 3461760 3462764 . - . ID=CDS1;locus_tag=Rv3093c;product=Hypothetical oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3462761 3463891 . - . ID=CDS1;locus_tag=Rv3094c;product=putative flavin-dependent oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.3.99.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.7.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3mkhA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.3.8.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 1bucA,1jqiA,2uxwA,1udyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1bucA,1jqiA,2uxwA,1udyA,Ontology_term=0051384/note:identified by similarity of predicted tertiary structure to PDB 1jqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jqiA,Ontology_term=0006637/note:identified by similarity of predicted tertiary structure to PDB 1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sirA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0006635/note:identified by similarity of predicted tertiary structure to PDB 1jqiA,2uxwA,1udyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jqiA,2uxwA,1udyA,Ontology_term=0051289/note:identified by similarity of predicted tertiary structure to PDB 1jqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jqiA,Ontology_term=0090181/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0009062/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0046322/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1rx0A,1ivhA,1jqiA,2uxwA,1udyA,1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rx0A,1ivhA,1jqiA,2uxwA,1udyA,1sirA,Ontology_term=0042594/note:identified by similarity of predicted tertiary structure to PDB 1jqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jqiA,Ontology_term=0001659/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0006568/note:identified by similarity of predicted tertiary structure to PDB 1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sirA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4n5fA,3mpiA,1rx0A,2z1qB,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4n5fA,3mpiA,1rx0A,2z1qB,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA,Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA,Ontology_term=0004361/note:identified by similarity of predicted tertiary structure to PDB 1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sirA,Ontology_term=0005730/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0016627/note:identified by similarity of predicted tertiary structure to PDB 4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0042645/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0000062/note:identified by similarity of predicted tertiary structure to PDB 1jqiA,1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jqiA,1sirA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3mpiA,2z1qB,1ukwA,4irnA,3owaA,2pg0A,3mkhA,5jscA,2ebaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mpiA,2z1qB,1ukwA,4irnA,3owaA,2pg0A,3mkhA,5jscA,2ebaA,Ontology_term=0004466/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0004085/note:identified by similarity of predicted tertiary structure to PDB 1bucA,1jqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1bucA,1jqiA,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 1rx0A,1ivhA,1jqiA,2uxwA,1udyA,1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rx0A,1ivhA,1jqiA,2uxwA,1udyA,1sirA,Ontology_term=0070991/note:identified by similarity of predicted tertiary structure to PDB 1udyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1udyA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 1rx0A,1bucA,1jqiA,2uxwA,1udyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rx0A,1bucA,1jqiA,2uxwA,1udyA,Ontology_term=0046359/note:identified by similarity of predicted tertiary structure to PDB 1jqiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jqiA,Ontology_term=0030855/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0031966/note:identified by similarity of predicted tertiary structure to PDB 1jqiA,2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jqiA,2uxwA,Ontology_term=0036498/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0003995/note:identified by similarity of predicted tertiary structure to PDB 4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,3owaA,3pfdA,2pg0A,5jscA,1bucA,1ivhA,4iv6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,3owaA,3pfdA,2pg0A,5jscA,1bucA,1ivhA,4iv6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,Ontology_term=0046949/note:identified by similarity of predicted tertiary structure to PDB 1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sirA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA,Ontology_term=0009409/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0019395/note:identified by similarity of predicted tertiary structure to PDB 1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sirA,Ontology_term=0045717/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4n5fA,3mpiA,1rx0A,2z1qB,2jifA,1ukwA,4irnA,3owaA,3pfdA,2pg0A,3mkhA,5jscA,1bucA,1ivhA,4iv6A,3sf6A,2ebaA,3ii9C,1jqiA,2uxwA,1udyA,1sirA,3swoA,Ontology_term=0008470/note:identified by similarity of predicted tertiary structure to PDB 1ivhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ivhA,Ontology_term=0006574/note:identified by similarity of predicted tertiary structure to PDB 1rx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rx0A,Ontology_term=0015980/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0033539/note:identified by similarity of predicted tertiary structure to PDB 1ivhA,1jqiA,2uxwA,1udyA,1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ivhA,1jqiA,2uxwA,1udyA,1sirA,Ontology_term=0006554/note:identified by similarity of predicted tertiary structure to PDB 1sirA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1sirA,Ontology_term=0006552/note:identified by similarity of predicted tertiary structure to PDB 1ivhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ivhA,Ontology_term=0052664/note:identified by similarity of predicted tertiary structure to PDB 3mkhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mkhA,Ontology_term=0005743/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 1rx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rx0A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 1rx0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rx0A,Ontology_term=0050141/note:identified by similarity of predicted tertiary structure to PDB 3mkhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mkhA,Ontology_term=0019439/note:identified by similarity of predicted tertiary structure to PDB 3mpiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mpiA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 2uxwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2uxwA,Ontology_term=0009083/note:identified by similarity of predicted tertiary structure to PDB 1rx0A,1ivhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rx0A,1ivhA chr1 CDS 3463973 3464449 . + . ID=CDS1;locus_tag=Rv3095;product=putative transcription factor;note=FunctionalCategory: regulatory proteins;Ontology_term=0032993/note:identified by similarity of predicted tertiary structure to PDB 5hs7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hs7A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 5hs7A,4a5mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hs7A,4a5mA,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 5hs7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hs7A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 5hs7A,4a5mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hs7A,4a5mA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 5hs7A,4a5mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hs7A,4a5mA,Ontology_term=0045892/note:identified by similarity of predicted tertiary structure to PDB 5hs7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hs7A,Ontology_term=0001217/note:identified by similarity of predicted tertiary structure to PDB 5hs7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5hs7A chr1 CDS 3464547 3465686 . + . ID=CDS1;locus_tag=Rv3096;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3465778 3467091 . - . ID=CDS1;locus_tag=Rv3097c;product=PE-PGRS family protein, triacylglycerol lipase LipY (esterase/lipase) (triglyceride lipase) (tributyrase);note=FunctionalCategory: PE/PPE chr1 CDS 3467210 3467662 . - . ID=CDS1;locus_tag=Rv3098c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3467606 3467926 . + . ID=CDS1;locus_tag=Rv3098A;product=PemK-like protein;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3468413 3469264 . - . ID=CDS1;locus_tag=Rv3099c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3469301 3469783 . - . ID=CDS1;locus_tag=Rv3100c;product=Probable SSRA-binding protein SmpB;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3469786 3470679 . - . ID=CDS1;locus_tag=Rv3101c;product=Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3470680 3471372 . - . ID=CDS1;locus_tag=Rv3102c;product=Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter);note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3471413 3471850 . - . ID=CDS1;locus_tag=Rv3103c;product=Hypothetical proline-rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3471852 3472778 . - . ID=CDS1;locus_tag=Rv3104c;product=Possible conserved transmembrane protein/putative membrane channel;note=FunctionalCategory: cell wall and cell processes, potentially mechanosensitive, identified by similarity of predicted tertiary structure to PDB 3t9nA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3t9nA chr1 CDS 3472768 3473904 . - . ID=CDS1;locus_tag=Rv3105c;product=Probable peptide chain release factor 2 PrfB (RF-2);note=FunctionalCategory: information pathways chr1 CDS 3474007 3475377 . + . ID=CDS1;locus_tag=Rv3106;product=NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3475378 3476961 . - . ID=CDS1;locus_tag=Rv3107c;product=Possible alkyldihydroxyacetonephosphate synthase AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3477060 3477500 . + . ID=CDS1;locus_tag=Rv3108;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3477649 3478728 . + . ID=CDS1;locus_tag=Rv3109;product=Probable molybdenum cofactor biosynthesis protein A MoaA1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3478779 3479174 . + . ID=CDS1;locus_tag=Rv3110;product=Probable pterin-4-alpha-carbinolamine dehydratase MoaB1 (PHS) (4-alpha- hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3479171 3479683 . + . ID=CDS1;locus_tag=Rv3111;product=Probable molybdenum cofactor biosynthesis protein C MoaC1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3479700 3479951 . + . ID=CDS1;locus_tag=Rv3112;product=Probable molybdenum cofactor biosynthesis protein D MoaD1 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3480074 3480742 . + . ID=CDS1;locus_tag=Rv3113;product=Possible phosphatase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3480759 3481289 . + . ID=CDS1;locus_tag=Rv3114;product=Putative cyclic amidine deminase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.4.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2g6vB,1z3aA,2b3jC,3zpcA,1ysdB,1wwrC,1vq2A,1wkqA,2d5nD,2hxvA,2nx8A,2hvwA,3dh1A,2w4lE/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004132/note:identified by similarity of predicted tertiary structure to PDB 1vq2A,2hvwA,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vq2A,2hvwA,2w4lE,Ontology_term=0004131/note:identified by similarity of predicted tertiary structure to PDB 1ysdB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ysdB,Ontology_term=0008251/note:identified by similarity of predicted tertiary structure to PDB 1z3aA,2b3jC,1wwrC,2nx8A,3dh1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z3aA,2b3jC,1wwrC,2nx8A,3dh1A,Ontology_term=0009451/note:identified by similarity of predicted tertiary structure to PDB 2hxvA,2d5nD,1ysdB,1wkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,2d5nD,1ysdB,1wkqA,Ontology_term=0102480/note:identified by similarity of predicted tertiary structure to PDB 1ysdB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ysdB,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,3dh1A,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,3dh1A,2w4lE,Ontology_term=0006147/note:identified by similarity of predicted tertiary structure to PDB 1wkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wkqA,Ontology_term=0008892/note:identified by similarity of predicted tertiary structure to PDB 1wkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wkqA,Ontology_term=0006220/note:identified by similarity of predicted tertiary structure to PDB 1vq2A,2hvwA,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vq2A,2hvwA,2w4lE,Ontology_term=0002100/note:identified by similarity of predicted tertiary structure to PDB 1z3aA,2b3jC,1wwrC,2nx8A,3dh1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z3aA,2b3jC,1wwrC,2nx8A,3dh1A,Ontology_term=0052717/note:identified by similarity of predicted tertiary structure to PDB 1z3aA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z3aA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2w4lE,Ontology_term=0006226/note:identified by similarity of predicted tertiary structure to PDB 2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2w4lE,Ontology_term=0044206/note:identified by similarity of predicted tertiary structure to PDB 1ysdB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ysdB,Ontology_term=0019858/note:identified by similarity of predicted tertiary structure to PDB 1ysdB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ysdB,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,2hxvA,2hvwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,2hxvA,2hvwA,Ontology_term=0019239/note:identified by similarity of predicted tertiary structure to PDB 2hxvA,2d5nD,1wwrC,1wkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hxvA,2d5nD,1wwrC,1wkqA,Ontology_term=0008835/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,3zpcA,2hxvA,2d5nD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,3zpcA,2hxvA,2d5nD,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,2w4lE,Ontology_term=0046087/note:identified by similarity of predicted tertiary structure to PDB 1ysdB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ysdB,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2w4lE,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,3dh1A,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,3dh1A,2w4lE,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 1z3aA,2b3jC,1wwrC,2nx8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z3aA,2b3jC,1wwrC,2nx8A,Ontology_term=0050661/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,3zpcA,2d5nD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,3zpcA,2d5nD,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,3dh1A,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,3zpcA,2hxvA,2d5nD,1z3aA,2b3jC,1ysdB,1wwrC,1vq2A,1wkqA,2nx8A,2hvwA,3dh1A,2w4lE,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2d5nD,1vq2A,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2d5nD,1vq2A,2w4lE,Ontology_term=0015949/note:identified by similarity of predicted tertiary structure to PDB 2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2w4lE,Ontology_term=0009231/note:identified by similarity of predicted tertiary structure to PDB 2g6vB,3zpcA,2hxvA,2d5nD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2g6vB,3zpcA,2hxvA,2d5nD,Ontology_term=0006231/note:identified by similarity of predicted tertiary structure to PDB 2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2w4lE,Ontology_term=0008655/note:identified by similarity of predicted tertiary structure to PDB 1ysdB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ysdB,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2w4lE,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2w4lE,Ontology_term=0009165/note:identified by similarity of predicted tertiary structure to PDB 1vq2A,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vq2A,2w4lE,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1ysdB,2w4lE/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ysdB,2w4lE,Ontology_term=0006144/note:identified by similarity of predicted tertiary structure to PDB 1wkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1wkqA chr1 CDS 3481451 3482698 . + . ID=CDS1;locus_tag=Rv3115;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3482776 3483945 . + . ID=CDS1;locus_tag=Rv3116;product=Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3483974 3484807 . + . ID=CDS1;locus_tag=Rv3117;product=Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3484809 3485111 . + . ID=CDS1;locus_tag=Rv3118;product=Conserved hypothetical protein SseC1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3485132 3485575 . + . ID=CDS1;locus_tag=Rv3119;product=Probable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3485572 3486174 . + . ID=CDS1;locus_tag=Rv3120;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 4necA,4krhA,4krhA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA,4krhA,4krhA2,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 4krhA,4krhA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4krhA,4krhA2,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 4krhA,4krhA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4krhA,4krhA2,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4necA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 4krhA,4krhA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4krhA,4krhA2,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 4necA,4krhA,4krhA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA,4krhA,4krhA2,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4krhA,4krhA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4krhA,4krhA2 chr1 CDS 3486509 3487711 . + . ID=CDS1;locus_tag=Rv3121;product=Probable cytochrome P450 141 Cyp141;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3488089 3488559 . + . ID=CDS1;locus_tag=Rv3122;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3488569 3489063 . + . ID=CDS1;locus_tag=Rv3123;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3489506 3490375 . + . ID=CDS1;locus_tag=Rv3124;product=Transcriptional regulatory protein MoaR1;note=FunctionalCategory: regulatory proteins chr1 CDS 3490476 3491651 . - . ID=CDS1;locus_tag=Rv3125c;gene=PPE49;product=PPE family protein PPE49;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 3491808 3492122 . - . ID=CDS1;locus_tag=Rv3126c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals, possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 3492147 3493181 . + . ID=CDS1;locus_tag=Rv3127;product=Conserved protein/Rv3127putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals, member of DosR regulon [PMID: 23287603], PATRIC calls this a nitroreductase;EC_number=1.-.-.-;Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2ymvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ymvA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2ymvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ymvA chr1 CDS 3493168 3494181 . + . ID=CDS1;locus_tag=Rv3128c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Contains integrase domain [PMID: 22759512], possible component of dormancy regulating DosR regulon [PMID: 28261197] chr1 CDS 3494660 3494992 . + . ID=CDS1;locus_tag=Rv3129;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3494975 3496366 . - . ID=CDS1;locus_tag=Rv3130c;product=Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1;note=FunctionalCategory: lipid metabolism chr1 CDS 3496551 3497549 . + . ID=CDS1;locus_tag=Rv3131;product=putative nitroreductase;Experiment=DESCRIPTION:cloned in E.coli, interaction assay with TLR2 in THP-1 and PBMC cells, RT-PCR [PMID: 27094446]/inference:ab initio prediction:3D structure prediction using Modeller, in silico docking studies [PMID: 27094446]/note:FunctionalCategory: conserved hypotheticals/note:induces cytokine expression in human via the TLR2 signaling pathway [PMID:27094446]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197];EC_number=1.7.1.- chr1 CDS 3497529 3499265 . - . ID=CDS1;locus_tag=Rv3132c;product=Two component sensor histidine kinase DevS;note=FunctionalCategory: regulatory proteins;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3499262 3499915 . - . ID=CDS1;locus_tag=Rv3133c;product=Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3499943 3500749 . - . ID=CDS1;locus_tag=Rv3134c;product=Universal stress protein family protein;Experiment=DESCRIPTION:targeted gene disruption, microarray analysis [PMID: 11416222]/note:FunctionalCategory: virulence, detoxification, adaptation/note:involved in the induction of alpha-crystallin (possibly involved in mycobacterial latency) [PMID: 11416222]/note:possible component of dormancy regulating DosR regulon [PMID: 28261197]/note:Phosphorylated DevR binds to P and D binding sites in the promoter of this gene [PMID: 18359816] chr1 CDS 3501334 3501732 . + . ID=CDS1;locus_tag=Rv3135;gene=PPE50;product=T-cell Antigen;Experiment=DESCRIPTION: ex vivo interferon-gamma ELISPOT assay [PMID: 26277695]/note:FunctionalCategory: PE/PPE/note:Essential for growth in vitro [PMID: 12657046]/note:Down-regulated on treatment with glycine/lysozyme [PMID: 23195184] chr1 CDS 3501794 3502936 . + . ID=CDS1;locus_tag=Rv3136;gene=PPE51;product=PPE family protein PPE51;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:SDS-PAGE, 2-D gel electrophoresis, multi-dimensional liquid chromatography and mass spectrometry [PMID: 20825248]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection [PMID: 21085642]/note:Located in the cell membrane [PMID: 21261938]/note:Located in the cell wall [PMID: 20825248] chr1 CDS 3502945 3503277 . - . ID=CDS1;locus_tag=Rv3136A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3503393 3504175 . + . ID=CDS1;locus_tag=Rv3137;product=Probable monophosphatase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3504195 3505283 . + . ID=CDS1;locus_tag=Rv3138;product=Probable pyruvate formate lyase activating protein PflA (formate acetyltransferase activating enzyme) ([pyruvate formate-lyase] activating enzyme);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3505363 3506769 . + . ID=CDS1;locus_tag=Rv3139;product=Probable acyl-CoA dehydrogenase FadE24;note=FunctionalCategory: lipid metabolism chr1 CDS 3506790 3507995 . + . ID=CDS1;locus_tag=Rv3140;product=Probable acyl-CoA dehydrogenase FadE23;note=FunctionalCategory: lipid metabolism chr1 CDS 3508095 3509066 . + . ID=CDS1;locus_tag=Rv3141;product=Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin);note=FunctionalCategory: lipid metabolism chr1 CDS 3509118 3509546 . - . ID=CDS1;locus_tag=Rv3142c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3509654 3510055 . + . ID=CDS1;locus_tag=Rv3143;product=Probable response regulator;note=FunctionalCategory: regulatory proteins chr1 CDS 3510088 3511317 . - . ID=CDS1;locus_tag=Rv3144c;product=PPE family protein PPE52;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642]/note:Expresses 2 positive cytotoxic T lymphocytes (CTL) epitopes [PMID: 21294723] chr1 CDS 3511682 3512068 . + . ID=CDS1;locus_tag=Rv3145;product=Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3512077 3512631 . + . ID=CDS1;locus_tag=Rv3146;product=Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3512628 3513338 . + . ID=CDS1;locus_tag=Rv3147;product=Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3513338 3514660 . + . ID=CDS1;locus_tag=Rv3148;product=Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3514657 3515415 . + . ID=CDS1;locus_tag=Rv3149;product=Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3515412 3516749 . + . ID=CDS1;locus_tag=Rv3150;product=Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3516746 3519166 . + . ID=CDS1;locus_tag=Rv3151;product=Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3519282 3520514 . + . ID=CDS1;locus_tag=Rv3152;product=Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3520507 3521142 . + . ID=CDS1;locus_tag=Rv3153;product=Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3521139 3521927 . + . ID=CDS1;locus_tag=Rv3154;product=Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3521924 3522223 . + . ID=CDS1;locus_tag=Rv3155;product=Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase chain K);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3522234 3524135 . + . ID=CDS1;locus_tag=Rv3156;product=Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3524132 3525793 . + . ID=CDS1;locus_tag=Rv3157;product=Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3525790 3527385 . + . ID=CDS1;locus_tag=Rv3158;product=Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3527391 3529163 . - . ID=CDS1;locus_tag=Rv3159c;gene=PPE53;product=PPE family protein PPE53/putative transporter (secretion system);Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642]/note:Stuctural and profile-sequence similarity to numerous secreted effector proteins/note:identified by similarity of predicted tertiary structure to PDB 4om9A,1wxrA,3h09B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4om9A,1wxrA,3h09B chr1 CDS 3529338 3529979 . - . ID=CDS1;locus_tag=Rv3160c;product=Possible transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3529990 3531138 . - . ID=CDS1;locus_tag=Rv3161c;product=Possible dioxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3531208 3531645 . - . ID=CDS1;locus_tag=Rv3162c;product=Possible integral membrane protein;note=FunctionalCategory: cell wall and cell processes, Induced significantly following Thioridazine [PMID: 20386700] chr1 CDS 3531642 3532913 . - . ID=CDS1;locus_tag=Rv3163c;product=Possible conserved secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3532943 3533905 . - . ID=CDS1;locus_tag=Rv3164c;product=Probable methanol dehydrogenase transcriptional regulatory protein MoxR3;note=FunctionalCategory: regulatory proteins chr1 CDS 3533913 3534395 . - . ID=CDS1;locus_tag=Rv3165c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3534392 3535351 . - . ID=CDS1;locus_tag=Rv3166c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Surface protein that may prevent mycobacterial entry to host cells [PMID: 22427370] chr1 CDS 3535431 3536057 . - . ID=CDS1;locus_tag=Rv3167c;product=Probable transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3536102 3537238 . + . ID=CDS1;locus_tag=Rv3168;product=Putative aminoglycoside phosphotransferase;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3537238 3538362 . + . ID=CDS1;locus_tag=Rv3169;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals, Negatively regulated by Rv3167c [PMID: 28270579] chr1 CDS 3538505 3539851 . + . ID=CDS1;locus_tag=Rv3170;product=Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3539846 3540745 . - . ID=CDS1;locus_tag=Rv3171c;product=Possible non-heme haloperoxidase Hpx;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3540882 3541364 . - . ID=CDS1;locus_tag=Rv3172c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3541443 3542045 . - . ID=CDS1;locus_tag=Rv3173c;product=Probable transcriptional regulatory protein (probably TetR/AcrR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3542138 3542845 . + . ID=CDS1;locus_tag=Rv3174;product=Probable short-chain dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3542860 3544347 . + . ID=CDS1;locus_tag=Rv3175;product=Possible amidase (aminohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3544344 3545300 . - . ID=CDS1;locus_tag=Rv3176c;product=Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3545447 3546307 . + . ID=CDS1;locus_tag=Rv3177;product=Possible peroxidase (non-haem peroxidase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3546438 3546797 . + . ID=CDS1;locus_tag=Rv3178;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,4y9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,4y9iA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,4y9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,4y9iA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3r5yA,4y9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3r5yA,4y9iA chr1 CDS 3547618 3548907 . + . ID=CDS1;locus_tag=Rv3179;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3549254 3549688 . - . ID=CDS1;locus_tag=Rv3180c;product=Probable VapC toxin/probable VapC toxin/putative ester hydrolase;Experiment=DESCRIPTION:plasmid construction, transformation in M. smegmatis, colony formation and growth assessment [PMID: 28066388]/note:FunctionalCategory: conserved hypotheticals/note:predicted to possess ribonuclease activity [PMID: 28066388];EC_number=3.1.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1w8iA,4xgqA,3tndA,2dokA,5sv2A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0045926/note:identified by similarity of predicted tertiary structure to PDB 4xgqA,5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4xgqA,5sv2A,Ontology_term=0090305/note:identified by similarity of predicted tertiary structure to PDB 1w8iA,4xgqA,3tndA,5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w8iA,4xgqA,3tndA,5sv2A,Ontology_term=0004540/note:identified by similarity of predicted tertiary structure to PDB 1w8iA,4xgqA,3tndA,5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w8iA,4xgqA,3tndA,5sv2A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1w8iA,4xgqA,3tndA,5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w8iA,4xgqA,3tndA,5sv2A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1w8iA,4xgqA,3tndA,5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w8iA,4xgqA,3tndA,5sv2A,Ontology_term=0090501/note:identified by similarity of predicted tertiary structure to PDB 1w8iA,4xgqA,3tndA,5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w8iA,4xgqA,3tndA,5sv2A,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 1w8iA,4xgqA,3tndA,5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w8iA,4xgqA,3tndA,5sv2A,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 3tndA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tndA,Ontology_term=0040008/note:identified by similarity of predicted tertiary structure to PDB 5sv2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5sv2A chr1 CDS 3549691 3550143 . - . ID=CDS1;locus_tag=Rv3181c;product=Probable VapB antitoxin;Experiment=DESCRIPTION:plasmid construction, transformation in M. smegmatis, colony formation and growth assessment [PMID: 28066388]/note:FunctionalCategory: conserved hypotheticals/note:predicted to possess ribonuclease activity [PMID: 28066388] chr1 CDS 3550374 3550718 . + . ID=CDS1;locus_tag=Rv3182;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3550715 3551044 . + . ID=CDS1;locus_tag=Rv3183;product=Possible transcriptional regulatory protein;note=FunctionalCategory: regulatory proteins chr1 CDS 3551281 3551607 . + . ID=CDS1;locus_tag=Rv3184;product=Probable transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 3551556 3552542 . + . ID=CDS1;locus_tag=Rv3185;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3552764 3553090 . + . ID=CDS1;locus_tag=Rv3186;product=Probable transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 3553039 3554025 . + . ID=CDS1;locus_tag=Rv3187;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3554298 3554645 . + . ID=CDS1;locus_tag=Rv3188;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3554642 3555262 . + . ID=CDS1;locus_tag=Rv3189;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3555422 3556687 . - . ID=CDS1;locus_tag=Rv3190c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3556855 3557064 . + . ID=CDS1;locus_tag=Rv3190A;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3557311 3558345 . - . ID=CDS1;locus_tag=Rv3191c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3559563 3560024 . + . ID=CDS1;locus_tag=Rv3192;product=putative monooxygenase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.14.14.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3fgcD,3fgcA,1nqkA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.5.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1z69A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.1.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3c8nA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004497/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,Ontology_term=0006730/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0008726/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0047646/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0019386/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0015948/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0008218/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA,1z69A,3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,1z69A,3c8nA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016705/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA,1z69A,3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,1z69A,3c8nA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0046306/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0045454/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3fgcD,3fgcA,1nqkA,1z69A,3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3fgcD,3fgcA,1nqkA,1z69A,3c8nA,Ontology_term=0052749/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016614/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0070967/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1nqkA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nqkA,Ontology_term=0018537/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A chr1 CDS 3560194 3563172 . - . ID=CDS1;locus_tag=Rv3193c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3563264 3564286 . - . ID=CDS1;locus_tag=Rv3194c;product=Possible conserved secreted protein/putative peptidase;note=FunctionalCategory: cell wall and cell processes, Potential periplasmic binding protein [PMID: 27858159];EC_number=3.4.-.- (Putative)/note:potential serine endopeptidase/note:identified by similarity of predicted tertiary structure to PDB 4yplA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4yplA chr1 CDS 3564364 3565782 . + . ID=CDS1;locus_tag=Rv3195;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3565788 3566687 . + . ID=CDS1;locus_tag=Rv3196;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3566696 3566896 . - . ID=CDS1;locus_tag=Rv3196A;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3567024 3568367 . + . ID=CDS1;locus_tag=Rv3197;product=Probable conserved ATP-binding protein ABC transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3568401 3568679 . - . ID=CDS1;locus_tag=Rv3197A;product=Probable transcriptional regulatory protein WhiB-like WhiB7;note=FunctionalCategory: regulatory proteins chr1 CDS 3569109 3571211 . - . ID=CDS1;locus_tag=Rv3198c;product=Probable ATP-dependent DNA helicase II UvrD2;note=FunctionalCategory: information pathways chr1 CDS 3571335 3571589 . + . ID=CDS1;locus_tag=Rv3198A;product=Possible glutaredoxin protein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3571602 3572543 . - . ID=CDS1;locus_tag=Rv3199c;product=Probable NADH pyrophosphatase NudC (NAD+ diphosphatase) (NAD+ pyrophosphatase) (NADP pyrophosphatase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3572602 3573669 . - . ID=CDS1;locus_tag=Rv3200c;product=Possible transmembrane cation transporter;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3573731 3577036 . - . ID=CDS1;locus_tag=Rv3201c;product=Probable ATP-dependent DNA helicase;note=FunctionalCategory: information pathways chr1 CDS 3577033 3580200 . - . ID=CDS1;locus_tag=Rv3202c;product=Possible ATP-dependent DNA helicase;note=FunctionalCategory: information pathways chr1 CDS 3580638 3581312 . + . ID=CDS1;locus_tag=Rv3203;product=Possible lipase LipV;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3581315 3581620 . + . ID=CDS1;locus_tag=Rv3204;product=Possible DNA-methyltransferase (modification methylase);note=FunctionalCategory: information pathways chr1 CDS 3581627 3582505 . - . ID=CDS1;locus_tag=Rv3205c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3582532 3583710 . - . ID=CDS1;locus_tag=Rv3206c;product=Probable molybdenum cofactor biosynthesis protein MoeB1 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3583801 3584658 . - . ID=CDS1;locus_tag=Rv3207c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3585004 3585690 . + . ID=CDS1;locus_tag=Rv3208;product=Probable transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3585677 3585949 . - . ID=CDS1;locus_tag=Rv3208A;product=Conserved protein TB9.4;Experiment=DESCRIPTION:affinity chromatography, mass spectrometry, isothermal titration calorimetry (ITC), crystallization [PMID: 25802331],Experiment=DESCRIPTION:protein isolation and precipitation, 2D-gel electrophoresis, in-gel digestion and mass spectrometry [PMID: 27895634]/inference:ab initio prediction:InterProScan [PMID: 27895634]/inference:ab initio prediction:Molecular docking [PMID: 27895634]/note:FunctionalCategory: conserved hypotheticals/note:over expressed in amikacin and kanamycin resistant isolates and the conserved domain of this gene is predicted to interact with these drugs [PMID: 27895634] chr1 CDS 3586274 3586834 . + . ID=CDS1;locus_tag=Rv3209;product=Conserved hypothetical threonine and proline rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3586844 3587539 . - . ID=CDS1;locus_tag=Rv3210c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3587798 3589381 . + . ID=CDS1;locus_tag=Rv3211;product=Probable ATP-dependent RNA helicase RhlE;note=FunctionalCategory: information pathways chr1 CDS 3589394 3590617 . + . ID=CDS1;locus_tag=Rv3212;product=Conserved alanine valine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3590692 3591492 . - . ID=CDS1;locus_tag=Rv3213c;product=Possible SOJ/para-related protein/putative transmembrane ATPase;Experiment=Bacterial culture, PCR, overexpression of recombinant proteins, fluorescence microscopy [PMID: 20006309]/inference:alignment:ClustalW2 [PMID: 20006309]/note:FunctionalCategory: cell wall and cell processes/note:probably important for chromosome segregation [PMID: 20006309]/note:putative ATPase activity [PMID: 20006309];EC_number=3.6.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB 3zq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3zq6A;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 4pfsA,2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pfsA,2bejA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0007059/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA chr1 CDS 3591646 3592257 . + . ID=CDS1;locus_tag=Rv3214;product=Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3592254 3593372 . + . ID=CDS1;locus_tag=Rv3215;product=Probable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3593369 3593852 . + . ID=CDS1;locus_tag=Rv3216;product=GCN5-related N-acetyltransferase, pseudogene;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3593804 3594235 . - . ID=CDS1;locus_tag=Rv3217c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3594468 3595433 . + . ID=CDS1;locus_tag=Rv3218;product=Conserved protein/putative phosphotransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2qv7A,3pfnA,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0030148/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 3afoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3afoA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0006457/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0006954/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0019674/note:identified by similarity of predicted tertiary structure to PDB 3pfnA,1yt5A,2an1B,3afoA,1suwA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pfnA,1yt5A,2an1B,3afoA,1suwA,1u0rD,Ontology_term=0016310/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD,Ontology_term=0019722/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0010803/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0010800/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0008481/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0007165/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0003951/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,3pfnA,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,3pfnA,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD,Ontology_term=0046521/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0035556/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0045987/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0048146/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0017050/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1yt5A,2an1B,1suwA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1yt5A,2an1B,1suwA,3vzdA,1u0rD,Ontology_term=0001727/note:identified by similarity of predicted tertiary structure to PDB 2p1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p1rA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u0rD,Ontology_term=0001568/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0045766/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD,Ontology_term=0046834/note:identified by similarity of predicted tertiary structure to PDB 2p1rA,3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2p1rA,3vzdA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD,Ontology_term=0043066/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0031398/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0030307/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0006741/note:identified by similarity of predicted tertiary structure to PDB 3pfnA,1yt5A,2an1B,3afoA,1suwA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pfnA,1yt5A,2an1B,3afoA,1suwA,1u0rD,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,2p1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,2p1rA,Ontology_term=0004143/note:identified by similarity of predicted tertiary structure to PDB 2qv7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD,Ontology_term=0008284/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0030335/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0051287/note:identified by similarity of predicted tertiary structure to PDB 2an1B,1suwA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2an1B,1suwA,1u0rD,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,2p1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,2p1rA,Ontology_term=0038036/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0016301/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 3afoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3afoA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,3pfnA,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,3pfnA,1yt5A,2an1B,3afoA,1suwA,2p1rA,3vzdA,1u0rD,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0042736/note:identified by similarity of predicted tertiary structure to PDB 3afoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3afoA,Ontology_term=0034599/note:identified by similarity of predicted tertiary structure to PDB 3afoA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3afoA,Ontology_term=0042346/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0051721/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0051092/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0003376/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0045931/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0007420/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0008654/note:identified by similarity of predicted tertiary structure to PDB 2qv7A,2p1rA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2qv7A,2p1rA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0006797/note:identified by similarity of predicted tertiary structure to PDB 1u0rD/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u0rD,Ontology_term=0005516/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3afoA,3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3afoA,3vzdA,Ontology_term=0032651/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0046512/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA,Ontology_term=0006670/note:identified by similarity of predicted tertiary structure to PDB 3vzdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vzdA chr1 CDS 3595713 3595967 . + . ID=CDS1;locus_tag=Rv3219;product=Transcriptional regulatory protein WhiB-like WhiB1. Contains [4FE-4S]2+ cluster.;note=FunctionalCategory: regulatory proteins chr1 CDS 3596029 3597534 . - . ID=CDS1;locus_tag=Rv3220c;product=Probable two component sensor kinase;note=FunctionalCategory: regulatory proteins chr1 CDS 3597551 3597766 . - . ID=CDS1;locus_tag=Rv3221c;product=Putative Dihydrolipoyllysine-residue acetyltransferase;note=FunctionalCategory: lipid metabolism;EC_number=2.3.1.12 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1iyuA/inference:ab initio prediction:I-TASSER:5.1/note:formerly known as Biotinylated protein TB7.3/note:may function as the dihydrolipoamide acetyltransferase component of a pyruvate dehydrigenase complex/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iyuA,1lacA chr1 CDS 3598051 3598356 . - . ID=CDS1;locus_tag=Rv3221A;product=Anti-sigma factor RshA;note=FunctionalCategory: information pathways chr1 CDS 3598353 3598904 . - . ID=CDS1;locus_tag=Rv3222c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3598901 3599551 . - . ID=CDS1;locus_tag=Rv3223c;product=Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE);note=FunctionalCategory: information pathways chr1 CDS 3599851 3600699 . + . ID=CDS1;locus_tag=Rv3224;product=Possible iron-regulated short-chain dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3600635 3600823 . + . ID=CDS1;locus_tag=Rv3224A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3600801 3601019 . + . ID=CDS1;locus_tag=Rv3224B;product=putative trans-editing enzyme;note=FunctionalCategory: conserved hypotheticals;EC_number=4.-.-.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1dbxA,2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dbxA,2dxaA,Ontology_term=0010165/note:identified by similarity of predicted tertiary structure to PDB 2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dxaA,Ontology_term=0006450/note:identified by similarity of predicted tertiary structure to PDB 1dbxA,2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dbxA,2dxaA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dxaA,Ontology_term=0006412/note:identified by similarity of predicted tertiary structure to PDB 1dbxA,2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dbxA,2dxaA,Ontology_term=0043906/note:identified by similarity of predicted tertiary structure to PDB 1dbxA,2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dbxA,2dxaA,Ontology_term=0043907/note:identified by similarity of predicted tertiary structure to PDB 2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dxaA,Ontology_term=0002161/note:identified by similarity of predicted tertiary structure to PDB 1dbxA,2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dbxA,2dxaA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 1dbxA,2dxaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1dbxA,2dxaA chr1 CDS 3601016 3602440 . - . ID=CDS1;locus_tag=Rv3225c;product=GCN5-related N-acetyltransferase, phosphorylase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3602564 3603322 . - . ID=CDS1;locus_tag=Rv3226c;product=putative peptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.-.-;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2icuB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2icuB,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 2icuB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2icuB,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 2icuB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2icuB chr1 CDS 3603377 3604729 . + . ID=CDS1;locus_tag=Rv3227;product=3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3604726 3605718 . + . ID=CDS1;locus_tag=Rv3228;product=putative acid anhydride phosphatase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0042254/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0003924/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0019843/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 1t9hA,1u0lA,2rcnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1t9hA,1u0lA,2rcnA chr1 CDS 3605751 3607034 . - . ID=CDS1;locus_tag=Rv3229c;product=Possible linoleoyl-CoA desaturase (delta(6)-desaturase);note=FunctionalCategory: lipid metabolism chr1 CDS 3607112 3608254 . - . ID=CDS1;locus_tag=Rv3230c;product=probable NADPH oxidoreductase;Experiment=DESCRIPTION:in vitro protein expression, desaturation assay [PMID: 17087501]/inference:ab initio prediction:protein threading [PMID: 17087501]/note:FunctionalCategory: intermediary metabolism and respiration/note:23% identical to phthalate dioxygenase reductase but protein threading with X-ray structure of phthalate dioxygenase reductase show structural homology including conserved residues making contact with the flavin cofactor and the NAD(P)H binding domain [PMID: 17087501];EC_number=1.2.1.-,EC_number=1.18.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2piaA,1qgaA,2b5oA,3jqqC,2bgjA,4b4dA,1krhA,4wqmA,2rc6A,1jb9A,1ewyA/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.14.12.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4eh1A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1gvhA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0032843/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0015979/note:identified by similarity of predicted tertiary structure to PDB 2b5oA,1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2b5oA,1jb9A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2b5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2b5oA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2bgjA,4b4dA,2rc6A,1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bgjA,4b4dA,2rc6A,1jb9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2piaA,1krhA,4wqmA,2rc6A,1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2piaA,1krhA,4wqmA,2rc6A,1gvhA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 2piaA,1qgaA,2b5oA,3jqqC,2bgjA,4b4dA,1krhA,4wqmA,2rc6A,1jb9A,1ewyA,4eh1A,1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2piaA,1qgaA,2b5oA,3jqqC,2bgjA,4b4dA,1krhA,4wqmA,2rc6A,1jb9A,1ewyA,4eh1A,1gvhA,Ontology_term=0019825/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0019439/note:identified by similarity of predicted tertiary structure to PDB 1krhA,4wqmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1krhA,4wqmA,Ontology_term=0008941/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0009579/note:identified by similarity of predicted tertiary structure to PDB 2b5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2b5oA,Ontology_term=0020037/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0071500/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 2piaA,1krhA,4wqmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2piaA,1krhA,4wqmA,Ontology_term=0051537/note:identified by similarity of predicted tertiary structure to PDB 2piaA,1krhA,4wqmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2piaA,1krhA,4wqmA,Ontology_term=0005344/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0003959/note:identified by similarity of predicted tertiary structure to PDB 1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jb9A,Ontology_term=0003954/note:identified by similarity of predicted tertiary structure to PDB 1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jb9A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 2piaA,1qgaA,2b5oA,3jqqC,2bgjA,4b4dA,1krhA,4wqmA,2rc6A,1jb9A,1ewyA,4eh1A,1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2piaA,1qgaA,2b5oA,3jqqC,2bgjA,4b4dA,1krhA,4wqmA,2rc6A,1jb9A,1ewyA,4eh1A,1gvhA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0006221/note:identified by similarity of predicted tertiary structure to PDB 4wqmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wqmA,Ontology_term=0004324/note:identified by similarity of predicted tertiary structure to PDB 2b5oA,2bgjA,4b4dA,2rc6A,1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2b5oA,2bgjA,4b4dA,2rc6A,1jb9A,Ontology_term=0022900/note:identified by similarity of predicted tertiary structure to PDB 1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jb9A,Ontology_term=0005504/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0015671/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0042651/note:identified by similarity of predicted tertiary structure to PDB 2b5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2b5oA,Ontology_term=0042203/note:identified by similarity of predicted tertiary structure to PDB 1krhA,4wqmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1krhA,4wqmA,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jb9A,Ontology_term=0016653/note:identified by similarity of predicted tertiary structure to PDB 1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jb9A,Ontology_term=0008860/note:identified by similarity of predicted tertiary structure to PDB 1krhA,4wqmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1krhA,4wqmA,Ontology_term=0071949/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 4wqmA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4wqmA,Ontology_term=0009636/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0030089/note:identified by similarity of predicted tertiary structure to PDB 2b5oA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2b5oA,Ontology_term=0046210/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0051409/note:identified by similarity of predicted tertiary structure to PDB 1gvhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1gvhA,Ontology_term=0009055/note:identified by similarity of predicted tertiary structure to PDB 2piaA,1krhA,4wqmA,1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2piaA,1krhA,4wqmA,1jb9A,Ontology_term=0070402/note:identified by similarity of predicted tertiary structure to PDB 1jb9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1jb9A chr1 CDS 3608364 3608873 . - . ID=CDS1;locus_tag=Rv3231c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3608870 3609757 . - . ID=CDS1;locus_tag=Rv3232c;product=Polyphosphate kinase Ppk2 (polyphosphoric acid kinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3609781 3610371 . - . ID=CDS1;locus_tag=Rv3233c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 3610374 3611189 . - . ID=CDS1;locus_tag=Rv3234c;product=Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3;note=FunctionalCategory: lipid metabolism chr1 CDS 3611300 3611941 . + . ID=CDS1;locus_tag=Rv3235;product=Hypothetical alanine arginine proline rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3611959 3613116 . - . ID=CDS1;locus_tag=Rv3236c;gene=kefB;product=Potassium/proton antiporter/Probable Na(+)/H(+) antiporter;Experiment=DESCRIPTION:In Vivo and in Vitro competition,Experiment=DESCRIPTION:gene disruption and complementation, co-localization/note:FunctionalCategory: cell wall and cell processes/note:probable potassium channel with mechanism of resistance to oxidative stress.[PMID: 14569030]/note:inhibits phagosomal acidification. [PMID: 24346161]/note:identified by similarity of predicted tertiary structure to PDB 4bwzA, 4czbA, 4cz8A, 1zcdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bwzA, 4czbA, 4cz8A, 1zcdA chr1 CDS 3613121 3613603 . - . ID=CDS1;locus_tag=Rv3237c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3613664 3614398 . - . ID=CDS1;locus_tag=Rv3238c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3614457 3617603 . - . ID=CDS1;locus_tag=Rv3239c;product=Probable conserved membrane transport protein;note=FunctionalCategory: cell wall and cell processes;Experiment=DESCRIPTION:PCR, Vector cloning, drug susceptibility assays [PMID: 12520088]/inference:similar to AA sequence:BLASTP [PMID: 12520088]/inference:alignment: ClustalW [PMID: 12520088]/note:cyclic nucleotide binding protein [PMID: 12520088]/note:upregulated in response to RIF [PMID: 21512166] chr1 CDS 3617682 3620531 . - . ID=CDS1;locus_tag=Rv3240c;product=Probable preprotein translocase SecA1 1 subunit;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3620610 3621254 . - . ID=CDS1;locus_tag=Rv3241c;product=Conserved protein;note=FunctionalCategory: information pathways chr1 CDS 3621570 3622211 . - . ID=CDS1;locus_tag=Rv3242c;product=phosphoribosyltransferase;Experiment=DESCRIPTION:mass spectrometry, enzymatic activity assay, recombinant mutant[PMID: 25825498]/note:FunctionalCategory: conserved hypotheticals/note:activates the MAPK pathway, NF-kB, and inflammatory cytokines, associated with the cell wall [PMID: 25825498];EC_number=2.4.2.- chr1 CDS 3622249 3623091 . - . ID=CDS1;locus_tag=Rv3243c;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3623159 3624910 . - . ID=CDS1;locus_tag=Rv3244c;product=Probable conserved lipoprotein LpqB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3624910 3626613 . - . ID=CDS1;locus_tag=Rv3245c;product=Two component sensory transduction histidine kinase MtrB;note=FunctionalCategory: regulatory proteins chr1 CDS 3626663 3627349 . - . ID=CDS1;locus_tag=Rv3246c;product=Two component sensory transduction transcriptional regulatory protein MtrA;note=FunctionalCategory: regulatory proteins chr1 CDS 3627419 3628063 . - . ID=CDS1;locus_tag=Rv3247c;product=Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3628160 3629647 . - . ID=CDS1;locus_tag=Rv3248c;product=Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3629752 3630387 . - . ID=CDS1;locus_tag=Rv3249c;product=Possible transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3630384 3630566 . - . ID=CDS1;locus_tag=Rv3250c;product=Probable rubredoxin RubB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3630571 3630738 . - . ID=CDS1;locus_tag=Rv3251c;product=Probable rubredoxin RubA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3630738 3631988 . - . ID=CDS1;locus_tag=Rv3252c;product=Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (fatty acid omega-hydroxylase) (alkane hydroxylase-rubredoxin);note=FunctionalCategory: lipid metabolism chr1 CDS 3632097 3633584 . - . ID=CDS1;locus_tag=Rv3253c;product=Possible cationic amino acid transport integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3633675 3635063 . + . ID=CDS1;locus_tag=Rv3254;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3635041 3636267 . - . ID=CDS1;locus_tag=Rv3255c;product=Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (phosphohexomutase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3636275 3637315 . - . ID=CDS1;locus_tag=Rv3256c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3637312 3638709 . - . ID=CDS1;locus_tag=Rv3257c;product=Probable phosphomannomutase PmmA (PMM) (phosphomannose mutase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3638811 3639302 . - . ID=CDS1;locus_tag=Rv3258c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3639425 3639844 . + . ID=CDS1;locus_tag=Rv3259;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3639872 3640141 . - . ID=CDS1;locus_tag=Rv3260c;product=Probable transcriptional regulatory protein WhiB-like WhiB2;note=FunctionalCategory: regulatory proteins chr1 CDS 3640543 3641538 . + . ID=CDS1;locus_tag=Rv3261;product=Probable F420 biosynthesis protein FbiA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3641535 3642881 . + . ID=CDS1;locus_tag=Rv3262;product=Probable F420 biosynthesis protein FbiB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3643177 3644838 . + . ID=CDS1;locus_tag=Rv3263;product=Probable DNA methylase (modification methylase) (methyltransferase);note=FunctionalCategory: information pathways chr1 CDS 3644898 3645977 . - . ID=CDS1;locus_tag=Rv3264c;product=D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (D-alpha-D-heptose-1-phosphate guanylyltransferase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3645979 3646884 . - . ID=CDS1;locus_tag=Rv3265c;product=dTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase WbbL1 (alpha-L-rhamnose-(1->3)-alpha-D-GlcNAc(1->P)-P-decaprenyl);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3646895 3647809 . - . ID=CDS1;locus_tag=Rv3266c;product=dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-rhamnose modification protein) (dTDP-rhamnose biosynthesis protein) (dTDP-rhamnose synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3647885 3649381 . + . ID=CDS1;locus_tag=Rv3267;product=probable peptidoglycan-arabinogalactan ligase;note=gene lcp1;Experiment=DESCRIPTION:cell-free (in vitro) biochemical functional radiolabel assay for ligase activity [PMID: 27486192]/inference:similar to AA sequence:[PMID: 27486192]/inference:protein motif:TMHMM [PMID: 27486192]/inference:ab initio prediction:I-TASSER [PMID: 27486192]/note:FunctionalCategory: conserved hypotheticals;EC_number=2.7.1.- chr1 CDS 3649420 3650109 . + . ID=CDS1;locus_tag=Rv3268;product=putative acid-thiol ligase;note=FunctionalCategory: conserved hypotheticals;EC_number=6.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3b7wA,3t5bA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,4eatA,1pg3B,1ry2A,3etcB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006633/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,3etcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,3etcB,Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,1ultA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,1ultA,Ontology_term=0015645/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,3etcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,3etcB,Ontology_term=0006637/note:identified by similarity of predicted tertiary structure to PDB 3etcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3etcB,Ontology_term=0005783/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0019654/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0016880/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0016207/note:identified by similarity of predicted tertiary structure to PDB 3tsyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tsyA,Ontology_term=0009698/note:identified by similarity of predicted tertiary structure to PDB 3tsyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tsyA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3tsyA,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tsyA,1ry2A,Ontology_term=0102391/note:identified by similarity of predicted tertiary structure to PDB 1ultA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ultA,Ontology_term=0004321/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,3etcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,3etcB,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3dlpX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dlpX,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,1ry2A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,1pg3B,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,1pg3B,1ry2A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3tsyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tsyA,Ontology_term=0004467/note:identified by similarity of predicted tertiary structure to PDB 1ultA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ultA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 3tsyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tsyA,Ontology_term=0019427/note:identified by similarity of predicted tertiary structure to PDB 5ifiA,1pg3B,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ifiA,1pg3B,1ry2A,Ontology_term=0016573/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 3b7wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,Ontology_term=0003987/note:identified by similarity of predicted tertiary structure to PDB 5ifiA,1pg3B,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ifiA,1pg3B,1ry2A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,3dlpX,1ultA,1pg3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,3dlpX,1ultA,1pg3B,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,5ifiA,1ultA,3tsyA,4eatA,1pg3B,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,5ifiA,1ultA,3tsyA,4eatA,1pg3B,1ry2A,Ontology_term=0070328/note:identified by similarity of predicted tertiary structure to PDB 3b7wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,1ultA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,1ultA,Ontology_term=0016208/note:identified by similarity of predicted tertiary structure to PDB 5ifiA,1pg3B,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5ifiA,1pg3B,1ry2A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,3t5bA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,4eatA,1pg3B,1ry2A,3etcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,3t5bA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,4eatA,1pg3B,1ry2A,3etcB,Ontology_term=0047760/note:identified by similarity of predicted tertiary structure to PDB 3b7wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,3t5bA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,4eatA,1pg3B,1ry2A,3etcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,3t5bA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,4eatA,1pg3B,1ry2A,3etcB,Ontology_term=0001676/note:identified by similarity of predicted tertiary structure to PDB 1ultA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ultA,Ontology_term=0016874/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,4eatA,1pg3B,1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,5ifiA,3dlpX,1ultA,3a9uA,3tsyA,4eatA,1pg3B,1ry2A,Ontology_term=0006085/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0043231/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0042593/note:identified by similarity of predicted tertiary structure to PDB 3b7wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0036112/note:identified by similarity of predicted tertiary structure to PDB 3b7wA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,Ontology_term=0009058/note:identified by similarity of predicted tertiary structure to PDB 3tsyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3tsyA,Ontology_term=0016405/note:identified by similarity of predicted tertiary structure to PDB 4eatA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4eatA,Ontology_term=0003996/note:identified by similarity of predicted tertiary structure to PDB 3b7wA,3etcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3b7wA,3etcB,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 1ry2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ry2A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 3dlpX/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dlpX chr1 CDS 3650234 3650515 . + . ID=CDS1;locus_tag=Rv3269;product=Conserved protein;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3650526 3652682 . + . ID=CDS1;locus_tag=Rv3270;product=Probable metal cation-transporting P-type ATPase C CtpC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3652679 3653347 . - . ID=CDS1;locus_tag=Rv3271c;product=Probable conserved integral membrane protein/putative cation transport protein;note=FunctionalCategory: cell wall and cell processes;Ontology_term=0008324/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0006812/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0098655/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1,Ontology_term=0055085/note:identified by similarity of predicted tertiary structure to PDB 3j1zP,3j1zP1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3j1zP,3j1zP1 chr1 CDS 3653448 3654632 . + . ID=CDS1;locus_tag=Rv3272;product=putative acetyl-CoA:oxalate CoA-transferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.8.3.19;Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4ed9A,4hl6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ed9A,4hl6A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4hl6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hl6A,Ontology_term=0036412/note:identified by similarity of predicted tertiary structure to PDB 4hl6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4hl6A chr1 CDS 3654661 3656931 . + . ID=CDS1;locus_tag=Rv3273;product=Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3656920 3658089 . - . ID=CDS1;locus_tag=Rv3274c;product=Probable acyl-CoA dehydrogenase FadE25;note=FunctionalCategory: lipid metabolism chr1 CDS 3658114 3658638 . - . ID=CDS1;locus_tag=Rv3275c;product=Probable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AIRC);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3658635 3659924 . - . ID=CDS1;locus_tag=Rv3276c;product=Probable phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AIRC);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3659878 3660696 . + . ID=CDS1;locus_tag=Rv3277;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3660651 3661169 . - . ID=CDS1;locus_tag=Rv3278c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3661212 3662012 . - . ID=CDS1;locus_tag=Rv3279c;product=Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3662062 3663708 . + . ID=CDS1;locus_tag=Rv3280;product=Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase);note=FunctionalCategory: lipid metabolism chr1 CDS 3663689 3664222 . + . ID=CDS1;locus_tag=Rv3281;product=Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (epsilon chain) AccE5;note=FunctionalCategory: lipid metabolism chr1 CDS 3664219 3664887 . + . ID=CDS1;locus_tag=Rv3282;product=putative nucleoside-triphosphate diphosphatase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.-;Ontology_term=0047429/note:identified by similarity of predicted tertiary structure to PDB 4oo0A,4jhcA,2p5xA,4p0eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4oo0A,4jhcA,2p5xA,4p0eA,Ontology_term=0036218/note:identified by similarity of predicted tertiary structure to PDB 4p0eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4p0eA,Ontology_term=0036221/note:identified by similarity of predicted tertiary structure to PDB 4p0eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4p0eA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 4p0eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4p0eA chr1 CDS 3664928 3665821 . + . ID=CDS1;locus_tag=Rv3283;product=Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3665818 3666249 . + . ID=CDS1;locus_tag=Rv3284;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3666357 3668159 . + . ID=CDS1;locus_tag=Rv3285;product=Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP);note=FunctionalCategory: lipid metabolism chr1 CDS 3668169 3668954 . - . ID=CDS1;locus_tag=Rv3286c;product=Alternative RNA polymerase sigma factor SigF;note=FunctionalCategory: information pathways chr1 CDS 3668951 3669457 . - . ID=CDS1;locus_tag=Rv3287c;product=Anti-sigma factor RsbW (sigma negative effector);note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3669586 3669999 . - . ID=CDS1;locus_tag=Rv3288c;product=Putative protein UsfY;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3670034 3670411 . - . ID=CDS1;locus_tag=Rv3289c;product=Possible transmembrane protein;note=FunctionalCategory: cell wall and cell processes, co-operonic with Rv3290c which has leaderless transcript [PMID: 24268774], expression increased >50-fold 24h following starvation [PMID: 24268774], Up-regulation is accompanied by up-regulation of an antisense transcript to lrpA (Rv3290c) [PMID: 24268774] chr1 CDS 3670445 3671794 . - . ID=CDS1;locus_tag=Rv3290c;product=Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3671845 3672297 . - . ID=CDS1;locus_tag=Rv3291c;product=Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3672328 3673575 . + . ID=CDS1;locus_tag=Rv3292;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3673602 3675086 . + . ID=CDS1;locus_tag=Rv3293;product=Probable piperideine-6-carboxilic acid dehydrogenase Pcd (piperideine-6-carboxylate dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3675186 3675995 . - . ID=CDS1;locus_tag=Rv3294c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3676066 3676731 . + . ID=CDS1;locus_tag=Rv3295;product=Probable transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3676775 3681316 . + . ID=CDS1;locus_tag=Rv3296;product=Probable ATP-dependent helicase Lhr (large helicase-related protein);note=FunctionalCategory: information pathways chr1 CDS 3681320 3682087 . + . ID=CDS1;locus_tag=Rv3297;product=Probable endonuclease VIII Nei;note=FunctionalCategory: information pathways chr1 CDS 3682110 3683024 . - . ID=CDS1;locus_tag=Rv3298c;product=Possible esterase lipoprotein LpqC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3683051 3685963 . - . ID=CDS1;locus_tag=Rv3299c;product=Probable arylsulfatase AtsB (aryl-sulfate sulphohydrolase) (sulfatase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3685983 3686900 . - . ID=CDS1;locus_tag=Rv3300c;product=putative pseudouridine synthase protein;note=FunctionalCategory: conserved hypotheticals;EC_number=5.4.99.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1xpiA,2istA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0009451/note:identified by similarity of predicted tertiary structure to PDB 1xpiA,2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xpiA,2istA,2i82A,Ontology_term=0000455/note:identified by similarity of predicted tertiary structure to PDB 2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,2i82A,Ontology_term=0001522/note:identified by similarity of predicted tertiary structure to PDB 1xpiA,2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xpiA,2istA,2i82A,Ontology_term=0000027/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0019239/note:identified by similarity of predicted tertiary structure to PDB 2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,2i82A,Ontology_term=0006364/note:identified by similarity of predicted tertiary structure to PDB 2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,2i82A,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2i82A,Ontology_term=0009982/note:identified by similarity of predicted tertiary structure to PDB 1xpiA,2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xpiA,2istA,2i82A,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,2i82A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 1xpiA,2istA,2i82A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xpiA,2istA,2i82A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2istA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2istA chr1 CDS 3686912 3687577 . - . ID=CDS1;locus_tag=Rv3301c;product=Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3687685 3689442 . - . ID=CDS1;locus_tag=Rv3302c;product=Probable glycerol-3-phosphate dehydrogenase GlpD2;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3689457 3690938 . - . ID=CDS1;locus_tag=Rv3303c;product=NAD(P)H quinone reductase LpdA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3691141 3691620 . + . ID=CDS1;locus_tag=Rv3304;product=Conserved protein/putative aminoacyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.3.2.-;Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA,Ontology_term=0001836/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA,Ontology_term=0016746/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA,Ontology_term=0006750/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA,Ontology_term=0003839/note:identified by similarity of predicted tertiary structure to PDB 2rbhA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rbhA chr1 CDS 3691639 3692808 . - . ID=CDS1;locus_tag=Rv3305c;product=Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3692805 3693989 . - . ID=CDS1;locus_tag=Rv3306c;product=Probable amidohydrolase AmiB1 (aminohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3694054 3694860 . + . ID=CDS1;locus_tag=Rv3307;product=Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3694864 3696468 . + . ID=CDS1;locus_tag=Rv3308;product=Probable phosphomannomutase PmmB (phosphomannose mutase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3696470 3697093 . - . ID=CDS1;locus_tag=Rv3309c;product=Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3697198 3698097 . + . ID=CDS1;locus_tag=Rv3310;product=Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3698121 3699383 . + . ID=CDS1;locus_tag=Rv3311;product=probable protease;Experiment=DESCRIPTION:protein cloning and expression, proteolysis assay with beta-casein, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.4.-.- chr1 CDS 3699404 3700330 . - . ID=CDS1;locus_tag=Rv3312c;product=probable serine hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.-,EC_number=1.11.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.7.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1u2eA,2vf2A,2pu5A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4opmA,1k8qA,3hi4A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0018771/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,Ontology_term=0044117/note:identified by similarity of predicted tertiary structure to PDB 2vf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 2vf2A,1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,1k8qA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 2vf2A,1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,1k8qA,Ontology_term=0034820/note:identified by similarity of predicted tertiary structure to PDB 2vf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 2vf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,Ontology_term=0005198/note:identified by similarity of predicted tertiary structure to PDB 3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vdxA,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A,Ontology_term=0018774/note:identified by similarity of predicted tertiary structure to PDB 2vf2A,2pu5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,2pu5A,Ontology_term=0019622/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A,Ontology_term=0004064/note:identified by similarity of predicted tertiary structure to PDB 3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hi4A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1u2eA,2vf2A,2pu5A,1k8qA,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,2vf2A,2pu5A,1k8qA,3hi4A,Ontology_term=0006694/note:identified by similarity of predicted tertiary structure to PDB 2vf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,Ontology_term=0102296/note:identified by similarity of predicted tertiary structure to PDB 2vf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,Ontology_term=0016823/note:identified by similarity of predicted tertiary structure to PDB 2pu5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pu5A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3vdxA,1a8sA,1a88A,1u2eA,2pu5A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3vdxA,1a8sA,1a88A,1u2eA,2pu5A,3hi4A,Ontology_term=0016788/note:identified by similarity of predicted tertiary structure to PDB 1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2vf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2vf2A,Ontology_term=0004806/note:identified by similarity of predicted tertiary structure to PDB 1k8qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1k8qA,Ontology_term=0052823/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0019380/note:identified by similarity of predicted tertiary structure to PDB 1u2eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 3vdxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vdxA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3e3aB,2vf2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3e3aB,2vf2A,Ontology_term=0019439/note:identified by similarity of predicted tertiary structure to PDB 1u2eA,2vf2A,2pu5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1u2eA,2vf2A,2pu5A,Ontology_term=0016691/note:identified by similarity of predicted tertiary structure to PDB 1a8sA,1a88A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8sA,1a88A,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1a8qA,3e3aB,3vdxA,1a8sA,1a88A,3hi4A chr1 CDS 3700705 3701016 . - . ID=CDS1;locus_tag=Rv3312A;gene=mtp;product=pilin subunit protein;Experiment=DESCRIPTION:Transmission electron microscopy, ImmunoGold electron microscopy, Protein purification, Antibody Production, Western-blot, Polymerase Chain Reaction, Flow cytometry, ELISA, ECM Binding Assay. [PMID: 17360408],Experiment=DESCRIPTION:qPCR. [PMID: 23907521]/note:FunctionalCategory: cell wall and cell processes/note:Required for M. Tuberculosis pili (MTP) Fiber production in M.tuberculosis. [PMID: 17360408]/note:Putatively part of an adherence factor. [PMID: 17360408]/note:Is not co-operonic with or located near other pilus-associated genes but is in between genes involved in intermediary metabolism (add, deoA, and cdd) [PMID: 23907521]/note:Putative genetic determinant in the long-term dormancy and persistence of M. tuberculosis.[PMID: 23907521]/note:Directly interacts with several potential transmembrane or secreted proteins and lipoprotein LpqX. [PMID: 20973567] chr1 CDS 3701087 3702184 . - . ID=CDS1;locus_tag=Rv3313c;product=Probable adenosine deaminase Add (adenosine aminohydrolase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3702184 3703467 . - . ID=CDS1;locus_tag=Rv3314c;product=Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3703464 3703865 . - . ID=CDS1;locus_tag=Rv3315c;product=Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3704030 3704440 . + . ID=CDS1;locus_tag=Rv3316;product=Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3704437 3704871 . + . ID=CDS1;locus_tag=Rv3317;product=Probable succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3705000 3706772 . + . ID=CDS1;locus_tag=Rv3318;product=Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3706772 3707563 . + . ID=CDS1;locus_tag=Rv3319;product=Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3707642 3708070 . - . ID=CDS1;locus_tag=Rv3320c;product=Possible toxin VapC44. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3708074 3708316 . - . ID=CDS1;locus_tag=Rv3321c;product=Possible antitoxin VapB44;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3708438 3709052 . - . ID=CDS1;locus_tag=Rv3322c;product=Possible methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3709049 3709714 . - . ID=CDS1;locus_tag=Rv3323c;product=Probable MoaD-MoaE fusion protein MoaX;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3709715 3710248 . - . ID=CDS1;locus_tag=Rv3324c;product=Probable molybdenum cofactor biosynthesis protein C 3 MoaC3;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3710245 3710379 . - . ID=CDS1;locus_tag=Rv3324A;product=Probable fragment of pterin-4-alpha-carbinolamine dehydratase MOAB3 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3710433 3710759 . + . ID=CDS1;locus_tag=Rv3325;product=Probable transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 3710708 3711694 . + . ID=CDS1;locus_tag=Rv3326;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3711749 3713461 . + . ID=CDS1;locus_tag=Rv3327;product=Probable transposase fusion protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3713394 3714332 . - . ID=CDS1;locus_tag=Rv3328c;product=Probable alternative RNA polymerase sigma factor (fragment) SigJ;note=FunctionalCategory: information pathways chr1 CDS 3714392 3715708 . + . ID=CDS1;locus_tag=Rv3329;product=Probable aminotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3715777 3716994 . + . ID=CDS1;locus_tag=Rv3330;product=Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3717090 3718598 . + . ID=CDS1;locus_tag=Rv3331;product=Probable sugar-transport integral membrane protein SugI;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3718595 3719746 . + . ID=CDS1;locus_tag=Rv3332;product=Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3719937 3720782 . - . ID=CDS1;locus_tag=Rv3333c;gene=ppr1;product=probable PDZ-interacting protease regulator (adaptor protein)/Ppr1;Experiment=DESCRIPTION:knockout, pulse chase, Q-RT-PCR [PMID: 24218594]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 3721257 3721697 . + . ID=CDS1;locus_tag=Rv3334;product=Probable transcriptional regulatory protein (probably MerR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3721731 3722600 . - . ID=CDS1;locus_tag=Rv3335c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3722621 3723631 . - . ID=CDS1;locus_tag=Rv3336c;product=Probable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tryptophan translase);note=FunctionalCategory: information pathways chr1 CDS 3723656 3724042 . + . ID=CDS1;locus_tag=Rv3337;product=putative hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 5a62A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a62A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 5a62A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5a62A chr1 CDS 3723904 3724548 . + . ID=CDS1;locus_tag=Rv3338;product=putative carboxylic ester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4uhcA,2xuaA,3hi4A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0047570/note:identified by similarity of predicted tertiary structure to PDB 2xuaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xuaA,Ontology_term=0004064/note:identified by similarity of predicted tertiary structure to PDB 3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hi4A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hi4A,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hi4A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4uhcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uhcA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2xuaA,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xuaA,3hi4A,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 4uhcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uhcA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 4uhcA,3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uhcA,3hi4A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hi4A,Ontology_term=0042952/note:identified by similarity of predicted tertiary structure to PDB 2xuaA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xuaA,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 3hi4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3hi4A chr1 CDS 3724615 3725844 . - . ID=CDS1;locus_tag=Rv3339c;product=Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3726127 3727476 . + . ID=CDS1;locus_tag=Rv3340;product=Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3727488 3728627 . + . ID=CDS1;locus_tag=Rv3341;product=Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3728624 3729355 . + . ID=CDS1;locus_tag=Rv3342;product=Possible methyltransferase (methylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3729364 3736935 . - . ID=CDS1;locus_tag=Rv3343c;gene=PPE54;product=PPE family protein PPE54;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642]/note:Essential for in vitro growth [PMID: 12657046]/note:Contains IS6110 insertion site [PMID: 22703188]/note:induced and exported in vivo [PMID: 28442606] chr1 CDS 3736984 3738438 . - . ID=CDS1;locus_tag=Rv3344c;gene=PE_PGRS49;product=PE-PGRS family protein PE_PGRS49;note=FunctionalCategory: PE/PPE chr1 CDS 3738158 3742774 . - . ID=CDS1;locus_tag=Rv3345c;gene=PE_PGRS50;product=PE-PGRS family protein PE_PGRS50;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642]/note:Upregulated in dosR mutant strains [PMID: 26270051]/note:Contains 77 copies of calcium-binding parallel beta-helix/beta-roll motif [PMID: 18267304] chr1 CDS 3743198 3743455 . - . ID=CDS1;locus_tag=Rv3346c;product=Conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3743711 3753184 . - . ID=CDS1;locus_tag=Rv3347c;gene=PPE55;product=Antigen/PPE family protein PPE55;Experiment=DESCRIPTION:Protein purification and expression, mouse recombinant protein immunization, ELISA, western blot [PMID: 28217905],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:possibly immunogenic in humans and involved in differentiating between latent and incipient subclinical tuberculosis (TB) [PMID: 16041015]/note:can induce production of high titres of specific IgG antibodies in mice [PMID: 28217905]/note:can specifically recognize TB-positive sera and the sera of mice immunized with the corresponding protein, which gives this gene diagnostic potential [PMID: 28217905]/note:biomarker in all infectious stages [PMID: 16041015]/note:recognized by antibodies during subclinical TB Guinea pig infection [PMID: 16041015]/note:inhibits antigen processing in host [PMID: 16041015]/note:can be recognized in blood of healthy individuals exposed to Mtb [PMID: 23497342] chr1 CDS 3753765 3754256 . + . ID=CDS1;locus_tag=Rv3348;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3754293 3755033 . - . ID=CDS1;locus_tag=Rv3349c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3755952 3757688 . - . ID=CDS1;locus_tag=Rv3350c;gene=PPE56;product=PPE family protein PPE56;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3767346 3768140 . - . ID=CDS1;locus_tag=Rv3351c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3768222 3768593 . - . ID=CDS1;locus_tag=Rv3352c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3768736 3768996 . - . ID=CDS1;locus_tag=Rv3353c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3769111 3769500 . + . ID=CDS1;locus_tag=Rv3354;product=protein kinase;Experiment=DESCRIPTION:in vitro activity of knockout-complementation, yeast two-hybrid screen, enzymatic assays[PMID: 25139900]/note:FunctionalCategory: conserved hypotheticals/note:Alters host ubiquitination system [PMID: 25139900];EC_number=2.7.-.- chr1 CDS 3769514 3769807 . - . ID=CDS1;locus_tag=Rv3355c;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3769804 3770649 . - . ID=CDS1;locus_tag=Rv3356c;product=Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3770773 3771048 . + . ID=CDS1;locus_tag=Rv3357;product=Antitoxin RelJ;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3771045 3771302 . + . ID=CDS1;locus_tag=Rv3358;product=Toxin RelK;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3771344 3772534 . + . ID=CDS1;locus_tag=Rv3359;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3772651 3773019 . + . ID=CDS1;locus_tag=Rv3360;product=putative phospho-dependent signal transduction protein;note=FunctionalCategory: conserved hypotheticals;EC_number=3.-.-.-;Ontology_term=0000160/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A,Ontology_term=0003924/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A,Ontology_term=0016887/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2ff4A2,2ff4A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ff4A2,2ff4A chr1 CDS 3773016 3773567 . - . ID=CDS1;locus_tag=Rv3361c;gene=mfpA;product=DNA topoisomerase (ATP-hydrolyzing) inhibitor, MfpA;Experiment=protein purification and overexpression, topoisomerase assays, DNA supercoiling assay, DNA cleavage assay, DNA relaxation assay [PMID: 19060136]/note:FunctionalCategory: conserved hypotheticals/note:increases inhibition of gyrA in presence of fluoroquinolones [PMID: 19060136]/note:directly affects catalysis by inhibiting the supercoiling of DNA gyrase [PMID: 19060136]/note:interacts with MfpB (Rv3362c), which is essential for fluoroquinolone resistance mediated by this protein (Rv3361c) in vivo [PMID: 23275532]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 3773574 3774155 . - . ID=CDS1;locus_tag=Rv3362c;gene=mfpB;product=DNA topoisomerase (ATP-hydrolyzing) inhibitor/GTPase, MfpB;Experiment=Isothermal Titration Calorimetry assays, SPR measurements, DNA gyrase supercoiling assays [PMID: 23275532]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.6.5.- (Putative)/note:interacts with MfpA (Rv3361c), which is essential for in vivo fluoroquinolone resistance [PMID: 23275532]/note:the GTPase activity of this protein allows it to bind MfpA (Rv3361c) [PMID: 23275532]/note:blocks MfpA-mediated inhibition of the supercoiling activity of DNA gyrase in vitro [PMID: 23275532]/note:interacts with MfpA (Rv3361c) to protect DNA gyrase from fluoroquinolones [PMID: 23275532]/note:isolates with mutations in this gene, and that lack mutations in pncA, have been shown to be resistant to PZA [PMID: 29020922]/note:identified by similarity of predicted tertiary structure to PDB:2f9mA,3t12A,4m9qA,2xtzA,3bc1A,4cymA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005741/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0005783/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0035773/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=1990126/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0061024/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,4cymA,Ontology_term=0007165/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=2001135/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0009740/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0030054/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0030742/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0031982/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0005834/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,2xtzA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,2xtzA,4cymA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,2xtzA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,2xtzA,4cymA,Ontology_term=0005769/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0009845/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0031905/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0016192/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0042127/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0005794/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0003924/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,2xtzA,3bc1A,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,2xtzA,3bc1A,4cymA,Ontology_term=0005095/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0016247/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0005789/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0006571/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,4cymA,Ontology_term=0010244/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=2000008/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0098993/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0036461/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0031683/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0010027/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0008219/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0045056/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0045054/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0045055/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0007188/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0009870/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0065009/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0007186/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,3t12A,4m9qA,2xtzA,3bc1A,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,3t12A,4m9qA,2xtzA,3bc1A,4cymA,Ontology_term=0019882/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0009738/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0009749/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0034260/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0045335/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,4cymA,Ontology_term=0031489/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0030672/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0030670/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,4cymA,Ontology_term=1903232/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0019001/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0019003/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0033572/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0071468/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0048639/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0055038/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0072593/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0055037/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0009785/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0009789/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0072657/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0001664/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0007005/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0033162/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0009788/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0031410/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,4cymA,Ontology_term=0008021/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,4cymA,Ontology_term=0009094/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0001789/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0071215/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0032402/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0043687/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0042470/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0009742/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0005622/note:identified by similarity of predicted tertiary structure to PDB 4m9qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4m9qA,Ontology_term=0045296/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0010476/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2f9mA,3t12A,2xtzA,4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,3t12A,2xtzA,4cymA,Ontology_term=0090150/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0045202/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0004871/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0044070/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0001881/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0090382/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0035646/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0035651/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0035650/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0010119/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0007264/note:identified by similarity of predicted tertiary structure to PDB 4m9qA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4m9qA,Ontology_term=0009506/note:identified by similarity of predicted tertiary structure to PDB 2xtzA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2xtzA,Ontology_term=0044233/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0005802/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0015031/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA,Ontology_term=0035612/note:identified by similarity of predicted tertiary structure to PDB 4cymA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4cymA,Ontology_term=0005768/note:identified by similarity of predicted tertiary structure to PDB 2f9mA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2f9mA chr1 CDS 3774136 3774504 . - . ID=CDS1;locus_tag=Rv3363c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3774482 3774874 . - . ID=CDS1;locus_tag=Rv3364c;product=Cathepsin G inhibitor/secreted effector;Experiment=DESCRIPTION: transposon mutagenesis, macrophage infection, cytokine measurement, apoptosis TUNEL assay, beta-lactamase assay, western blot, target host protein pull-up assay, enzymatic activity assays, inactivation via siRNA, inhibition assays [PMID: 22275911]/note:FunctionalCategory: conserved hypotheticals/note:Can enter the host cell cystosol, bind to, and inhibit protease cathepsin G, which has a downstream effect of inhibiting caspase-1 mediated apoptosis [PMID: 22275911];Dbxref=GeneID:888085 chr1 CDS 3774871 3777501 . - . ID=CDS1;locus_tag=Rv3365c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:significantly upregulated by overexpression of furA (Rv1909c) [PMID: 27328747]/note:significantly downregulated during hypoxia [PMID: 27328747] chr1 CDS 3777737 3778201 . + . ID=CDS1;locus_tag=Rv3366;product=Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase);note=FunctionalCategory: information pathways chr1 CDS 3778568 3780334 . + . ID=CDS1;locus_tag=Rv3367;gene=PE_PGRS51;product=PE-PGRS family protein PE_PGRS51;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642]/note:Upregulated after exposure to capreomycin [PMID: 21678479] chr1 CDS 3780335 3780979 . - . ID=CDS1;locus_tag=Rv3368c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3780978 3781412 . + . ID=CDS1;locus_tag=Rv3369;product=Conserved protein/Putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.3.-.-;Ontology_term=0070967/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0016627/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 3db0B,5jabA,3f7eA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3db0B,5jabA,3f7eA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0009986/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 5jabA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:5jabA chr1 CDS 3781501 3784740 . - . ID=CDS1;locus_tag=Rv3370c;product=Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase);note=FunctionalCategory: information pathways chr1 CDS 3784932 3786272 . + . ID=CDS1;locus_tag=Rv3371;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 3786314 3787489 . + . ID=CDS1;locus_tag=Rv3372;product=Trehalose 6-phosphate phosphatase OtsB2 (trehalose-phosphatase) (TPP);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3787726 3788367 . + . ID=CDS1;locus_tag=Rv3373;product=Probable enoyl-CoA hydratase EchA18 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 3788368 3788616 . + . ID=CDS1;locus_tag=Rv3374;product=Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 3788621 3790048 . + . ID=CDS1;locus_tag=Rv3375;product=Probable amidase AmiD (acylamidase) (acylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3790156 3790809 . + . ID=CDS1;locus_tag=Rv3376;product=Phosphatase/phosphatase/putative phosphotransferase;Experiment=DESCRIPTION:Protein expression and purification, enzyme activity assay, substrate specificity assay [PMID: 21228491]/note:FunctionalCategory: conserved hypotheticals/note:known to hydrolyze geranyl diphosphate (GPP), farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) to yield geraniol, farnesol, geranylgeraniol respectively [PMID: 21228491];EC_number=3.1.-.-,EC_number=5.4.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2wheA,4g9bA,4gibA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA,4gibA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,4gibA,Ontology_term=0008801/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA,4gibA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,4gibA,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 4g9bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4g9bA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,Ontology_term=0009294/note:identified by similarity of predicted tertiary structure to PDB 4g9bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4g9bA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA,4gibA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,4gibA,Ontology_term=0006974/note:identified by similarity of predicted tertiary structure to PDB 4g9bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4g9bA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA,4gibA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,4gibA,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA,4gibA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,4gibA,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 2wheA,4g9bA,4gibA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wheA,4g9bA,4gibA chr1 CDS 3790848 3792353 . - . ID=CDS1;locus_tag=Rv3377c;product=Halimadienyl diphosphate synthase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3792358 3793248 . - . ID=CDS1;locus_tag=Rv3378c;product=Diterpene synthase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3793257 3794867 . - . ID=CDS1;locus_tag=Rv3379c;product=Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3795100 3796086 . - . ID=CDS1;locus_tag=Rv3380c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3796035 3796361 . - . ID=CDS1;locus_tag=Rv3381c;product=Probable transposase for insertion sequence element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 3796448 3797437 . - . ID=CDS1;locus_tag=Rv3382c;product=Probable LYTB-related protein LytB1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3797437 3798489 . - . ID=CDS1;locus_tag=Rv3383c;product=Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3799243 3799635 . - . ID=CDS1;locus_tag=Rv3384c;product=Possible toxin VapC46. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3799635 3799943 . - . ID=CDS1;locus_tag=Rv3385c;product=Possible antitoxin VapB46;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3800092 3800796 . + . ID=CDS1;locus_tag=Rv3386;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3800786 3801463 . + . ID=CDS1;locus_tag=Rv3387;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3801653 3803848 . + . ID=CDS1;locus_tag=Rv3388;gene=PE_PGRS52;product=PE-PGRS family protein PE_PGRS52;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 30 but not 90 days post-infection [PMID: 21085642] chr1 CDS 3803919 3804791 . - . ID=CDS1;locus_tag=Rv3389c;product=Probable 3-hydroxyacyl-thioester dehydratase HtdY;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3804865 3805575 . + . ID=CDS1;locus_tag=Rv3390;product=Probable conserved lipoprotein LpqD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3805621 3807573 . + . ID=CDS1;locus_tag=Rv3391;product=Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1;note=FunctionalCategory: lipid metabolism chr1 CDS 3807574 3808437 . - . ID=CDS1;locus_tag=Rv3392c;product=Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1);note=FunctionalCategory: lipid metabolism chr1 CDS 3808461 3809387 . + . ID=CDS1;locus_tag=Rv3393;product=Probable nucleoside hydrolase IunH (purine nucleosidase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3809442 3811025 . - . ID=CDS1;locus_tag=Rv3394c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3811022 3811636 . - . ID=CDS1;locus_tag=Rv3395c;product=putative NTP-dependent DNA damage response protein;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.-.-;Ontology_term=0006310/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0008094/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0010212/note:identified by similarity of predicted tertiary structure to PDB 3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,Ontology_term=0006302/note:identified by similarity of predicted tertiary structure to PDB 1xp8A,1xp8A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xp8A,1xp8A1,Ontology_term=0009432/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0006281/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0009314/note:identified by similarity of predicted tertiary structure to PDB 3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,Ontology_term=0048870/note:identified by similarity of predicted tertiary structure to PDB 3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0006974/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0006259/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0003697/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ubgA,1xp8A,3hr8A1,3cmuA1,3cmuA2,3cmuA5,3cmuA4,3cmuA6,3cmuA,3hr8A,1xp8A1,1ubgA1 chr1 CDS 3811719 3812345 . + . ID=CDS1;locus_tag=Rv3395A;product=Probable membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3812501 3812791 . - . ID=CDS1;locus_tag=Rv3396c;product=Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3814090 3814998 . - . ID=CDS1;locus_tag=Rv3397c;product=Probable phytoene synthase PhyA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3815027 3816106 . - . ID=CDS1;locus_tag=Rv3398c;product=Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase): dimethylallyltransferase (prenyltransferase) (geranyl-diphosphate synthase) + geranyltranstransferase (farnesyl-diphosphate synthase) (farnesyl-pyrophosphate synthetase) (farnesyl diphosphate synthetase) (FPP synthetase) + farnesyltranstransferase (geranylgeranyl-diphosphate synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3816129 3817175 . + . ID=CDS1;locus_tag=Rv3399;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 3817239 3818027 . + . ID=CDS1;locus_tag=Rv3400;product=Probable hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3818042 3820402 . + . ID=CDS1;locus_tag=Rv3401;product=probable serine hydrolase, Putative Maltose phosphorylase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography-mass spectrometry (LC-MS)[PMID: 26853625]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:FunctionalCategory: intermediary metabolism and respiration/note:predicted to be homologous to trehalose phosphorylase, but trehalose phosphorylase is shown to be non-essential for Mycobacterium tuberculosis [PMID: 15703182];EC_number=3.2.1.-,EC_number=2.4.1.8 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1h54B/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0030246/note:identified by similarity of predicted tertiary structure to PDB 1h54B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1h54B,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1h54B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1h54B,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 1h54B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1h54B chr1 CDS 3820653 3821891 . - . ID=CDS1;locus_tag=Rv3402c;product= cell envelope-associated protein/putative hydro-lyase;Experiment=DESCRIPTION:protein expression and purification, western blot, proteinase K and trypsin sensitivity assay, cytokine production assay [PMID: 24722253]/note:FunctionalCategory: cell wall and cell processes/note:Probable inducer of inflammatory cytokine (TNF-a and IL-1b) production. [PMID: 24722253]/note:enhances intracellular persistence and survival of Mycobacterium within macrophages. [PMID: 24722253]/note:putatively engages in the biosynthesis of lipopolysaccharide (LPS)-like molecule. [PMID: 11722747]/note:repressed by IdeR and induced by iron limited conditions. [PMID: 11722747];EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1b9iA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 1b9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b9iA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 1b9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b9iA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1b9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b9iA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1b9iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1b9iA chr1 CDS 3822262 3823863 . - . ID=CDS1;locus_tag=Rv3403c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3823880 3824584 . - . ID=CDS1;locus_tag=Rv3404c;product=putative sugar N-formyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3av3A,1mejB,3kcqC,3tqrA,2fmtA,3da8A,4s1nA,4ds3A,3tqqA,1cdeA,4xczA,3q0iA,2ywrA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006431/note:identified by similarity of predicted tertiary structure to PDB 3q0iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3q0iA,Ontology_term=0046653/note:identified by similarity of predicted tertiary structure to PDB 3da8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3da8A,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 3da8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3da8A,Ontology_term=0016742/note:identified by similarity of predicted tertiary structure to PDB 3av3A,1mejB,3kcqC,3tqrA,2fmtA,3da8A,4s1nA,4ds3A,3tqqA,1cdeA,4xczA,3q0iA,2ywrA,2cfiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3av3A,1mejB,3kcqC,3tqrA,2fmtA,3da8A,4s1nA,4ds3A,3tqqA,1cdeA,4xczA,3q0iA,2ywrA,2cfiA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3av3A,3kcqC,3tqrA,2fmtA,3da8A,4s1nA,4ds3A,3tqqA,1cdeA,3q0iA,2ywrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3av3A,3kcqC,3tqrA,2fmtA,3da8A,4s1nA,4ds3A,3tqqA,1cdeA,3q0iA,2ywrA,Ontology_term=0006974/note:identified by similarity of predicted tertiary structure to PDB 1cdeA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1cdeA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2fmtA,3tqqA,4xczA,3q0iA,2cfiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fmtA,3tqqA,4xczA,3q0iA,2cfiA,Ontology_term=0009058/note:identified by similarity of predicted tertiary structure to PDB 3av3A,1mejB,3kcqC,3tqrA,2fmtA,3da8A,4s1nA,4ds3A,3tqqA,1cdeA,4xczA,3q0iA,2ywrA,2cfiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3av3A,1mejB,3kcqC,3tqrA,2fmtA,3da8A,4s1nA,4ds3A,3tqqA,1cdeA,4xczA,3q0iA,2ywrA,2cfiA,Ontology_term=0006189/note:identified by similarity of predicted tertiary structure to PDB 3av3A,1mejB,3kcqC,3tqrA,3da8A,4s1nA,4ds3A,1cdeA,2ywrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3av3A,1mejB,3kcqC,3tqrA,3da8A,4s1nA,4ds3A,1cdeA,2ywrA,Ontology_term=0019988/note:identified by similarity of predicted tertiary structure to PDB 2fmtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fmtA,Ontology_term=0004479/note:identified by similarity of predicted tertiary structure to PDB 2fmtA,3tqqA,3q0iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fmtA,3tqqA,3q0iA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3da8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3da8A,Ontology_term=0071951/note:identified by similarity of predicted tertiary structure to PDB 2fmtA,3tqqA,3q0iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fmtA,3tqqA,3q0iA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2fmtA,1cdeA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fmtA,1cdeA,Ontology_term=0004644/note:identified by similarity of predicted tertiary structure to PDB 3av3A,1mejB,3kcqC,3tqrA,3da8A,4s1nA,4ds3A,1cdeA,2ywrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3av3A,1mejB,3kcqC,3tqrA,3da8A,4s1nA,4ds3A,1cdeA,2ywrA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3da8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3da8A,Ontology_term=0006164/note:identified by similarity of predicted tertiary structure to PDB 3av3A,3kcqC,3tqrA,3da8A,4s1nA,4ds3A,1cdeA,2ywrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3av3A,3kcqC,3tqrA,3da8A,4s1nA,4ds3A,1cdeA,2ywrA,Ontology_term=0006413/note:identified by similarity of predicted tertiary structure to PDB 2fmtA,3tqqA,3q0iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fmtA,3tqqA,3q0iA,Ontology_term=0006412/note:identified by similarity of predicted tertiary structure to PDB 2fmtA,3tqqA,3q0iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2fmtA,3tqqA,3q0iA chr1 CDS 3824702 3825268 . - . ID=CDS1;locus_tag=Rv3405c;product=Possible transcriptional regulatory protein/putative transcription factor;note=FunctionalCategory: regulatory proteins, Involved in PGLs biosynthesis. [PMID: 17954004], Encode transcriptional repressor of expression on Rv3406, a a-ketoglutarate-dependent sulfate ester dioxygenase. [PMID: 25427196];Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3mnlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3mnlA chr1 CDS 3825330 3826217 . + . ID=CDS1;locus_tag=Rv3406;product=Probable dioxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3826252 3826551 . + . ID=CDS1;locus_tag=Rv3407;product=Possible antitoxin VapB47;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3826548 3826958 . + . ID=CDS1;locus_tag=Rv3408;product=Possible toxin VapC47. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3826991 3828727 . - . ID=CDS1;locus_tag=Rv3409c;product=Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase);note=FunctionalCategory: lipid metabolism chr1 CDS 3828783 3829910 . - . ID=CDS1;locus_tag=Rv3410c;product=Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3829930 3831519 . - . ID=CDS1;locus_tag=Rv3411c;product=Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3831726 3832136 . + . ID=CDS1;locus_tag=Rv3412;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3832146 3833045 . - . ID=CDS1;locus_tag=Rv3413c;product=Unknown alanine and proline rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3833038 3833676 . - . ID=CDS1;locus_tag=Rv3414c;product=Probable alternative RNA polymerase sigma-D factor SigD;note=FunctionalCategory: information pathways chr1 CDS 3833694 3834521 . - . ID=CDS1;locus_tag=Rv3415c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3834892 3835200 . + . ID=CDS1;locus_tag=Rv3416;product=Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster.;note=FunctionalCategory: regulatory proteins chr1 CDS 3835272 3836891 . - . ID=CDS1;locus_tag=Rv3417c;product=60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3836986 3837288 . - . ID=CDS1;locus_tag=Rv3418c;product=10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3837555 3838589 . - . ID=CDS1;locus_tag=Rv3419c;product=Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3838586 3839062 . - . ID=CDS1;locus_tag=Rv3420c;product=Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18);note=FunctionalCategory: information pathways chr1 CDS 3839059 3839694 . - . ID=CDS1;locus_tag=Rv3421c;gene=tsaB;product=putative tRNA threonylcarbamoyladenosine biosynthesis protein;note=FunctionalCategory: conserved hypotheticals, This gene is referred to as tsaB in multiple publications (based on homology and synteny in other bacterial organisms) but has not yet been characterized in Mtb;EC_number=3.-.-.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB,Ontology_term=0002949/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB,Ontology_term=0008237/note:identified by similarity of predicted tertiary structure to PDB 1okjB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1okjB chr1 CDS 3839691 3840197 . - . ID=CDS1;locus_tag=Rv3422c;gene=tsaE;product=putative tRNA modification enzyme;note=FunctionalCategory: conserved hypotheticals, interacts in vivo with Rv3419c. [PMID: 27353550];Experiment=DESCRIPTION:Mycobacterial Protein Fragment Complementation Assay [PMID: 27353550];Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1htwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1htwA,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 1htwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1htwA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1htwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1htwA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1htwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1htwA,Ontology_term=0002949/note:identified by similarity of predicted tertiary structure to PDB 1htwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1htwA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1htwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1htwA chr1 CDS 3840194 3841420 . - . ID=CDS1;locus_tag=Rv3423c;product=Alanine racemase Alr;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3841714 3842076 . - . ID=CDS1;locus_tag=Rv3424c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3842239 3842769 . + . ID=CDS1;locus_tag=Rv3425;gene=PPE57;product=B-cell antigen;Experiment=DESCRIPTION: Protein Expression and purification, ELISA [PMID: 17328725]/note:FunctionalCategory: PE/PPE/note:Possess novel cytotoxic T lymphocyte epitopes [PMID: 22537173]/note:Elicits strong humoral and cellular immune responses in mice after immunization [PMID: 18426397]/note:Recognized by T-cells in individuals from HLA backgrounds that represented all frequently expressed HLA-DR molecules [PMID: 23136116]/note:Expressed during exponential growth in vitro [PMID: 17328725] chr1 CDS 3843036 3843734 . + . ID=CDS1;locus_tag=Rv3426;gene=PPE58;product=PPE family protein PPE58;note=FunctionalCategory: PE/PPE chr1 CDS 3843885 3844640 . - . ID=CDS1;locus_tag=Rv3427c;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3844738 3845970 . - . ID=CDS1;locus_tag=Rv3428c;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3847165 3847701 . + . ID=CDS1;locus_tag=Rv3429;gene=PPE59;product=PPE family protein PPE59;note=FunctionalCategory: PE/PPE chr1 CDS 3847642 3848805 . - . ID=CDS1;locus_tag=Rv3430c;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3849294 3850139 . - . ID=CDS1;locus_tag=Rv3431c;product=Possible transposase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 3850372 3851754 . - . ID=CDS1;locus_tag=Rv3432c;product=Probable glutamate decarboxylase GadB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3851792 3853213 . - . ID=CDS1;locus_tag=Rv3433c;product=putative NAD(P)H-hydrate repair enzyme;note=FunctionalCategory: conserved hypotheticals, appears homologous nnr would likely be a suitable gene name;EC_number=4.2.1.136,EC_number=5.1.99.6;Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A,Ontology_term=0052855/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2ax3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ax3A chr1 CDS 3853215 3853928 . - . ID=CDS1;locus_tag=Rv3434c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, upregulated by furA overexpression [PMID: 27328747] chr1 CDS 3853939 3854793 . - . ID=CDS1;locus_tag=Rv3435c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes, down-regulated during dormancy (vitamin C model) [PMID: 25645949] chr1 CDS 3855015 3856889 . - . ID=CDS1;locus_tag=Rv3436c;product=Probable glucosamine--fructose-6-phosphate aminotransferase [isomerizing] GlmS (hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (glucosamine-6-phosphate synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3856986 3857387 . + . ID=CDS1;locus_tag=Rv3437;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3857397 3858239 . + . ID=CDS1;locus_tag=Rv3438;product=Conserved protein/putative Carboxylic Ester Hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2fx5A,2pm8A,2fj0A,1q83A,1qo9A,1mx9D,4v2iA,3f98A,4eb0A,1qe3A,1aknA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0034441/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0034440/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0034374/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0042135/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0008285/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0005788/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,1mx9D,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0007612/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0019899/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0043083/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0051384/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0045202/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0001507/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0042426/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0090122/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0043279/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0030054/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0031225/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,1qo9A,Ontology_term=0014016/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0090026/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0052689/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,1qo9A,1mx9D,4v2iA,1qe3A,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,1qo9A,1mx9D,4v2iA,1qe3A,1aknA,Ontology_term=0047499/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0042331/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0005543/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0009636/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0072562/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0016042/note:identified by similarity of predicted tertiary structure to PDB 3f98A,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,1aknA,Ontology_term=0046469/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0047374/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0050783/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0004771/note:identified by similarity of predicted tertiary structure to PDB 1mx9D,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,1aknA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,2fj0A,1qo9A,1mx9D,4v2iA,3f98A,4eb0A,1qe3A,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,2fj0A,1qo9A,1mx9D,4v2iA,3f98A,4eb0A,1qe3A,1aknA,Ontology_term=0034362/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3f98A,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,1aknA,Ontology_term=0006581/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0007584/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0030855/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0016788/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,3f98A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0050729/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0003847/note:identified by similarity of predicted tertiary structure to PDB 3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f98A,Ontology_term=0050525/note:identified by similarity of predicted tertiary structure to PDB 4eb0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4eb0A,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 1mx9D,4v2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,4v2iA,Ontology_term=0007268/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0006805/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0001540/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0005615/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,3f98A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,3f98A,Ontology_term=0051791/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0004104/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,1q83A,1qo9A,1qe3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,1q83A,1qo9A,1qe3A,Ontology_term=0004806/note:identified by similarity of predicted tertiary structure to PDB 1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1aknA,Ontology_term=0051593/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0043199/note:identified by similarity of predicted tertiary structure to PDB 1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,Ontology_term=0005641/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0042493/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1qo9A,3f98A,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qo9A,3f98A,1aknA,Ontology_term=0019695/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,3f98A,1aknA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,3f98A,1aknA,Ontology_term=0006695/note:identified by similarity of predicted tertiary structure to PDB 1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1mx9D,Ontology_term=0033265/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0050805/note:identified by similarity of predicted tertiary structure to PDB 2pm8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,Ontology_term=0005783/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,1mx9D/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,1mx9D,Ontology_term=0003990/note:identified by similarity of predicted tertiary structure to PDB 2pm8A,1qo9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2pm8A,1qo9A chr1 CDS 3858259 3859662 . - . ID=CDS1;locus_tag=Rv3439c;product=Conserved hypothetical alanine and proline rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3859665 3859976 . - . ID=CDS1;locus_tag=Rv3440c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3860024 3861370 . - . ID=CDS1;locus_tag=Rv3441c;product=Probable phospho-sugar mutase/MrsA protein homolog;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3861495 3861950 . - . ID=CDS1;locus_tag=Rv3442c;product=30S ribosomal protein S9 RpsI;note=FunctionalCategory: information pathways;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3861947 3862390 . - . ID=CDS1;locus_tag=Rv3443c;product=50S ribosomal protein L13 RplM;note=FunctionalCategory: information pathways chr1 CDS 3862624 3862926 . - . ID=CDS1;locus_tag=Rv3444c;product=Putative ESAT-6 like protein EsxT;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3862947 3863264 . - . ID=CDS1;locus_tag=Rv3445c;product=ESAT-6 like protein EsxU;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3863317 3864531 . - . ID=CDS1;locus_tag=Rv3446c;product=Hypothetical alanine and valine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3864528 3868238 . - . ID=CDS1;locus_tag=Rv3447c;product=ESX conserved component EccC4. ESX-4 type VII secretion system protein. Probable membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3868352 3869755 . + . ID=CDS1;locus_tag=Rv3448;product=ESX conserved component EccD4. ESX-4 type VII secretion system protein. Probable integral membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3869752 3871119 . + . ID=CDS1;locus_tag=Rv3449;product=Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3871084 3872496 . - . ID=CDS1;locus_tag=Rv3450c;product=ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3872617 3873405 . + . ID=CDS1;locus_tag=Rv3451;product=Probable cutinase precursor Cut3;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3873452 3874132 . + . ID=CDS1;locus_tag=Rv3452;product=Probable cutinase precursor Cut4;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3874404 3874736 . + . ID=CDS1;locus_tag=Rv3453;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3874822 3876090 . + . ID=CDS1;locus_tag=Rv3454;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3876052 3876822 . - . ID=CDS1;locus_tag=Rv3455c;product=Probable tRNA pseudouridine synthase a TruA (pseudouridylate synthase I) (pseudouridine synthase I) (uracil hydrolyase);note=FunctionalCategory: information pathways chr1 CDS 3876890 3877432 . - . ID=CDS1;locus_tag=Rv3456c;product=50S ribosomal protein L17 RplQ;note=FunctionalCategory: information pathways chr1 CDS 3877464 3878507 . - . ID=CDS1;locus_tag=Rv3457c;product=Probable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed RNA nucleotidyltransferase);note=FunctionalCategory: information pathways chr1 CDS 3878659 3879264 . - . ID=CDS1;locus_tag=Rv3458c;product=30S ribosomal protein S4 RpsD;note=FunctionalCategory: information pathways chr1 CDS 3879273 3879692 . - . ID=CDS1;locus_tag=Rv3459c;product=30S ribosomal protein S11 RpsK;note=FunctionalCategory: information pathways chr1 CDS 3879696 3880070 . - . ID=CDS1;locus_tag=Rv3460c;product=30S ribosomal protein S13 RpsM;note=FunctionalCategory: information pathways chr1 CDS 3880286 3880399 . - . ID=CDS1;locus_tag=Rv3461c;product=50S ribosomal protein L36 RpmJ;note=FunctionalCategory: information pathways chr1 CDS 3880432 3880653 . - . ID=CDS1;locus_tag=Rv3462c;product=Probable translation initiation factor if-1 InfA;note=FunctionalCategory: information pathways chr1 CDS 3880907 3881764 . + . ID=CDS1;locus_tag=Rv3463;product=putative F420-dependent oxidoreductase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=1.5.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1z69A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.1.98.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3c8nA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006730/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0019386/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0005975/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1z69A,3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,3c8nA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016705/note:identified by similarity of predicted tertiary structure to PDB 1z69A,3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,3c8nA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0015948/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,Ontology_term=0045454/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1z69A,3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A,3c8nA,Ontology_term=0052749/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0016614/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0070967/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3c8nA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3c8nA,Ontology_term=0018537/note:identified by similarity of predicted tertiary structure to PDB 1z69A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1z69A chr1 CDS 3881837 3882832 . + . ID=CDS1;locus_tag=Rv3464;product=dTDP-glucose 4,6-dehydratase RmlB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3882834 3883442 . + . ID=CDS1;locus_tag=Rv3465;product=dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3883525 3884193 . + . ID=CDS1;locus_tag=Rv3466;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages, Bound and likely regulated by LexA, an activator of DNA damage response proteins [PMID: 14617159] chr1 CDS 3883964 3884917 . + . ID=CDS1;locus_tag=Rv3467;product=Conserved hypothetical protein;note=FunctionalCategory: insertion seqs and phages chr1 CDS 3884975 3886069 . - . ID=CDS1;locus_tag=Rv3468c;product=Possible dTDP-glucose 4,6-dehydratase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3886073 3887083 . - . ID=CDS1;locus_tag=Rv3469c;product=Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3887144 3888802 . - . ID=CDS1;locus_tag=Rv3470c;product=Probable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3888808 3889341 . - . ID=CDS1;locus_tag=Rv3471c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3889362 3889868 . + . ID=CDS1;locus_tag=Rv3472;product=putative oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.-.-.-;Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3ebyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ebyA,Ontology_term=0006725/note:identified by similarity of predicted tertiary structure to PDB 3ebyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ebyA,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 3ebyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ebyA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3ebyA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ebyA chr1 CDS 3889948 3890733 . - . ID=CDS1;locus_tag=Rv3473c;product=Possible peroxidase BpoA (non-haem peroxidase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3890830 3891156 . + . ID=CDS1;locus_tag=Rv3474;product=Possible transposase for insertion element IS6110 (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 3891105 3892091 . + . ID=CDS1;locus_tag=Rv3475;product=Possible transposase for insertion element IS6110 [second part];note=FunctionalCategory: insertion seqs and phages chr1 CDS 3892371 3893720 . - . ID=CDS1;locus_tag=Rv3476c;product=Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3894093 3894389 . + . ID=CDS1;locus_tag=Rv3477;gene=PE31;product=PE family protein PE31;Experiment=EXISTENCE:gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:found in the cell membrane and whole-cell lysate but absent in culture filtrate [PMID: 21920479] chr1 CDS 3894426 3895607 . + . ID=CDS1;locus_tag=Rv3478;gene=PPE60;product=PE family protein PPE60;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=EXISTENCE:label-free quantitative proteomics, mass spectrometry [PMID: 21261938]/note:FunctionalCategory: PE/PPE/note:Located in the cell membrane [PMID: 21261938]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642]/note:Vaccine candidate, Induced a strong pulmonary protective response and reduced mycobacterial CFU count by at least 70% in mice infected with M. tuberculosis [PMID: 23906890]/note:induced and exported in vivo [PMID: 28442606] chr1 CDS 3895820 3898885 . + . ID=CDS1;locus_tag=Rv3479;product=Possible transmembrane protein;note=FunctionalCategory: cell wall and cell processes, shows groEL1-dependent differential expression under low aeration stress [PMID: 26822628] chr1 CDS 3898909 3900402 . - . ID=CDS1;locus_tag=Rv3480c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 3900493 3901182 . - . ID=CDS1;locus_tag=Rv3481c;product=Probable integral membrane protein;note=FunctionalCategory: cell wall and cell processes, repressed by acid shock [PMID: 12081975] chr1 CDS 3901324 3902106 . - . ID=CDS1;locus_tag=Rv3482c;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3902150 3902812 . - . ID=CDS1;locus_tag=Rv3483c;product=Possible exported protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3903078 3904616 . + . ID=CDS1;locus_tag=Rv3484;product=Possible conserved protein CpsA;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3904622 3905452 . - . ID=CDS1;locus_tag=Rv3485c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3905730 3906221 . + . ID=CDS1;locus_tag=Rv3486;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3906174 3907007 . - . ID=CDS1;locus_tag=Rv3487c;product=Probable esterase/lipase LipF;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3907667 3907990 . + . ID=CDS1;locus_tag=Rv3488;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 3f3xA,3bpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f3xA,3bpxA,Ontology_term=0044212/note:identified by similarity of predicted tertiary structure to PDB 3f3xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f3xA,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 3f3xA,3bpxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3f3xA,3bpxA chr1 CDS 3908072 3908236 . + . ID=CDS1;locus_tag=Rv3489;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3908236 3909738 . + . ID=CDS1;locus_tag=Rv3490;product=Alpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-UDP glucosyl transferase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3909890 3910468 . + . ID=CDS1;locus_tag=Rv3491;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3910465 3910947 . - . ID=CDS1;locus_tag=Rv3492c;product=Conserved hypothetical Mce associated protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3910947 3911675 . - . ID=CDS1;locus_tag=Rv3493c;product=Conserved hypothetical Mce associated alanine and valine rich protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3911675 3913369 . - . ID=CDS1;locus_tag=Rv3494c;product=Mce-family protein Mce4F;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3913380 3914534 . - . ID=CDS1;locus_tag=Rv3495c;product=Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E);note=FunctionalCategory: cell wall and cell processes chr1 CDS 3914531 3915886 . - . ID=CDS1;locus_tag=Rv3496c;product=Mce-family protein Mce4D;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3915883 3916956 . - . ID=CDS1;locus_tag=Rv3497c;product=Mce-family protein Mce4C;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3916946 3917998 . - . ID=CDS1;locus_tag=Rv3498c;product=Mce-family protein Mce4B;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3917998 3919200 . - . ID=CDS1;locus_tag=Rv3499c;product=Mce-family protein Mce4A;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3919220 3920062 . - . ID=CDS1;locus_tag=Rv3500c;product=Conserved integral membrane protein YrbE4B. Possible ABC transporter.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 3920097 3920861 . - . ID=CDS1;locus_tag=Rv3501c;product=Conserved integral membrane protein YrbE4A. Possible ABC transporter.;note=FunctionalCategory: virulence, detoxification, adaptation;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 3921087 3922040 . - . ID=CDS1;locus_tag=Rv3502c;product=Probable short-chain type dehydrogenase/reductase. Possible 17-beta-hydroxysteroid dehydrogenase.;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3922065 3922256 . - . ID=CDS1;locus_tag=Rv3503c;product=Probable ferredoxin FdxD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3922471 3923673 . + . ID=CDS1;locus_tag=Rv3504;product=Probable acyl-CoA dehydrogenase FadE26;note=FunctionalCategory: lipid metabolism chr1 CDS 3923698 3924819 . + . ID=CDS1;locus_tag=Rv3505;product=Probable acyl-CoA dehydrogenase FadE27;note=FunctionalCategory: lipid metabolism chr1 CDS 3924890 3926398 . + . ID=CDS1;locus_tag=Rv3506;product=Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase);note=FunctionalCategory: lipid metabolism chr1 CDS 3926569 3930714 . + . ID=CDS1;locus_tag=Rv3507;gene=PE_PGRS53;product=PE-PGRS family protein PE_PGRS53;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642]/note:Upregulated on treatment with glycine/lysozyme [PMID: 23195184] chr1 CDS 3931005 3936710 . + . ID=CDS1;locus_tag=Rv3508;gene=PE_PGRS54;product=PE-PGRS family protein PE_PGRS54;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Induced under hypoxic conditions [PMID: 12694625]/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 3936877 3938424 . - . ID=CDS1;locus_tag=Rv3509c;product=Probable acetohydroxyacid synthase IlvX (acetolactate synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3938421 3939257 . - . ID=CDS1;locus_tag=Rv3510c;product= putative carboxy-lyase/putative linear amide hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2dvtA,4hjwA,2wm1A,2f6kA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.5.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3nurA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016831/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0001760/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=1905012/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0070062/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0006569/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=1904985/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2dvtA,4hjwA,2wm1A,2f6kA,3nurA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dvtA,4hjwA,2wm1A,2f6kA,3nurA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2dvtA,4hjwA,2wm1A,2f6kA,3nurA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2dvtA,4hjwA,2wm1A,2f6kA,3nurA,Ontology_term=1905004/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0051259/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2wm1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wm1A chr1 CDS 3939617 3941761 . + . ID=CDS1;locus_tag=Rv3511;gene=PE_PGRS55;product=PE-PGRS family protein PE_PGRS55;note=FunctionalCategory: PE/PPE chr1 CDS 3941724 3944963 . + . ID=CDS1;locus_tag=Rv3512;gene=PE_PGRS56;product=PE-PGRS family protein PE_PGRS56;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642]/note:Possibly contributes to pathogenicity of Mycobacterium tuberculosis [PMID: 21924330] chr1 CDS 3945092 3945748 . - . ID=CDS1;locus_tag=Rv3513c;product=Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3945794 3950263 . + . ID=CDS1;locus_tag=Rv3514;gene=PE_PGRS57;product=PE-PGRS family protein PE_PGRS57;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642]/note:down-regulated on treatment with glycine/lysozyme [PMID: 23195184] chr1 CDS 3950824 3952470 . - . ID=CDS1;locus_tag=Rv3515c;product=Fatty-acid-CoA ligase FadD19 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 3952544 3953335 . + . ID=CDS1;locus_tag=Rv3516;product=Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 3953431 3954270 . + . ID=CDS1;locus_tag=Rv3517;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3954325 3955521 . - . ID=CDS1;locus_tag=Rv3518c;product=Probable cytochrome P450 monooxygenase 142 Cyp142;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3955550 3956260 . + . ID=CDS1;locus_tag=Rv3519;product=Unknown protein/putative carboxy-lyase;note=FunctionalCategory: conserved hypotheticals;EC_number=4.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3bh3D,3c8wA,3bh2A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0047602/note:identified by similarity of predicted tertiary structure to PDB 3bh3D,3c8wA,3bh2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bh3D,3c8wA,3bh2A,Ontology_term=0016831/note:identified by similarity of predicted tertiary structure to PDB 3bh3D,3bh2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bh3D,3bh2A,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3bh3D,3c8wA,3bh2A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3bh3D,3c8wA,3bh2A chr1 CDS 3956325 3957368 . - . ID=CDS1;locus_tag=Rv3520c;product=Possible coenzyme F420-dependent oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3957521 3958432 . + . ID=CDS1;locus_tag=Rv3521;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3958448 3959512 . + . ID=CDS1;locus_tag=Rv3522;product=Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4;note=FunctionalCategory: lipid metabolism chr1 CDS 3959529 3960713 . + . ID=CDS1;locus_tag=Rv3523;product=Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3;note=FunctionalCategory: lipid metabolism chr1 CDS 3960755 3961786 . + . ID=CDS1;locus_tag=Rv3524;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 3961800 3962324 . - . ID=CDS1;locus_tag=Rv3525c;product=Possible siderophore-binding protein;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3962439 3963599 . + . ID=CDS1;locus_tag=Rv3526;product=Oxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3963605 3964054 . + . ID=CDS1;locus_tag=Rv3527;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3964479 3965192 . - . ID=CDS1;locus_tag=Rv3528c;product=probable serine hydrolase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals;EC_number=3.1.-.- chr1 CDS 3965884 3967038 . - . ID=CDS1;locus_tag=Rv3529c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3967038 3967820 . - . ID=CDS1;locus_tag=Rv3530c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3967817 3968944 . - . ID=CDS1;locus_tag=Rv3531c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3969343 3970563 . + . ID=CDS1;locus_tag=Rv3532;gene=PPE61;product=PPE family protein PPE61;note=FunctionalCategory: PE/PPE, Upregulated on treatment with glycine/lysozyme [PMID: 23195184] chr1 CDS 3970705 3972453 . - . ID=CDS1;locus_tag=Rv3533c;gene=PPE62;product=PPE family protein PPE62;note=FunctionalCategory: PE/PPE, Required for efficient heme utilization by M. tuberculosis. [PMID: 28119467], possible host antibody mimicry protein, strong structural similarity to secretory component of human secretory immunoglobulin A and similar to Rv0538., identified by similarity of predicted tertiary structure to PDB 1iq6B,2c2iA,5cpgA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,2c2iA,5cpgA chr1 CDS 3972552 3973592 . - . ID=CDS1;locus_tag=Rv3534c;product=Probable 4-hydroxy-2-oxovalerate aldolase (HOA);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3973589 3974500 . - . ID=CDS1;locus_tag=Rv3535c;product=Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3974511 3975296 . - . ID=CDS1;locus_tag=Rv3536c;product=Probable hydratase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3975369 3977060 . + . ID=CDS1;locus_tag=Rv3537;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3977062 3977922 . + . ID=CDS1;locus_tag=Rv3538;product=Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3978059 3979498 . + . ID=CDS1;locus_tag=Rv3539;gene=PPE63;product=PPE family protein PPE63;note=FunctionalCategory: PE/PPE chr1 CDS 3979499 3980659 . - . ID=CDS1;locus_tag=Rv3540c;product=Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2;note=FunctionalCategory: lipid metabolism chr1 CDS 3980659 3981048 . - . ID=CDS1;locus_tag=Rv3541c;gene=chsH1;product=(R)-enoyl-coA dehydrogenase (ChsH1)/Putative cysteine endopeptidase/(R)-enoyl-coA dehydrogenase (ChsH1)/Putative oxidoreductase;Experiment=DESCRIPTION:expression and purification in E.coli, hydratase activity assay, crystallization and X-ray diffraction [PMID: 25203216]/note:FunctionalCategory: conserved hypotheticals/note:likely forms a2b2 heterotetramer with Rv3542c (named ChsH2) [PMID: 25203216];EC_number=4.2.1.17,EC_number=1.1.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3omlA/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.2.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1iq6B,2c2iA,1pn4D,1s9cG,4rljA,3kh8A,5cpgA/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.4.22.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3omlA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006633/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,2c2iA,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,2c2iA,5cpgA,Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 3omlA,1iq6B,2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,1iq6B,2c2iA,Ontology_term=0006635/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0080023/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA,Ontology_term=0005835/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,5cpgA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3omlA,1iq6B,2c2iA,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,1iq6B,2c2iA,5cpgA,Ontology_term=0005777/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0004300/note:identified by similarity of predicted tertiary structure to PDB 3omlA,2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,2c2iA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0018812/note:identified by similarity of predicted tertiary structure to PDB 2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c2iA,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 3omlA,1iq6B,2c2iA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,1iq6B,2c2iA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3omlA,1iq6B,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,1iq6B,5cpgA,Ontology_term=0004312/note:identified by similarity of predicted tertiary structure to PDB 1iq6B,5cpgA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1iq6B,5cpgA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2c2iA,4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2c2iA,4rljA,Ontology_term=0033540/note:identified by similarity of predicted tertiary structure to PDB 3omlA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3omlA,Ontology_term=0019171/note:identified by similarity of predicted tertiary structure to PDB 4rljA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4rljA chr1 CDS 3981045 3981980 . - . ID=CDS1;locus_tag=Rv3542c;gene=chsH2;product=(R)-enoyl-coA dehydrogenase (ChsH2);Experiment=DESCRIPTION:expression and purification in E.coli, hydratase activity assay, crystallization and X-ray diffraction [PMID: 25203216]/note:FunctionalCategory: conserved hypotheticals/note:likely forms a2b2 heterotetramer with Rv3541c (named ChsH1) [PMID: 25203216];EC_number=4.2.1.17 chr1 CDS 3981977 3983140 . - . ID=CDS1;locus_tag=Rv3543c;product=Probable acyl-CoA dehydrogenase FadE29;note=FunctionalCategory: lipid metabolism chr1 CDS 3983125 3984144 . - . ID=CDS1;locus_tag=Rv3544c;product=Probable acyl-CoA dehydrogenase FadE28;note=FunctionalCategory: lipid metabolism chr1 CDS 3984144 3985445 . - . ID=CDS1;locus_tag=Rv3545c;product=Probable cytochrome P450 125 Cyp125;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3985557 3986732 . + . ID=CDS1;locus_tag=Rv3546;product=Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase);note=FunctionalCategory: lipid metabolism chr1 CDS 3986844 3987299 . + . ID=CDS1;locus_tag=Rv3547;product=Deazaflavin-dependent nitroreductase Ddn;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3987382 3988296 . - . ID=CDS1;locus_tag=Rv3548c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3988319 3989098 . - . ID=CDS1;locus_tag=Rv3549c;product=Probable short-chain type dehydrogenase/reductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3989153 3989896 . + . ID=CDS1;locus_tag=Rv3550;product=Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 3989896 3990774 . + . ID=CDS1;locus_tag=Rv3551;product=Possible CoA-transferase (alpha subunit);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3990771 3991523 . + . ID=CDS1;locus_tag=Rv3552;product=Possible CoA-transferase (beta subunit);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3991621 3992688 . + . ID=CDS1;locus_tag=Rv3553;product=Putative nitronate monooxygenase;Experiment=DESCRIPTION:recombinant DNA expression, enzyme activity assay, inhibition assay [PMID: 23408846]/note:FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3992685 3994742 . + . ID=CDS1;locus_tag=Rv3554;product=Possible electron transfer protein FdxB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 3994830 3995699 . - . ID=CDS1;locus_tag=Rv3555c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 3995804 3996964 . - . ID=CDS1;locus_tag=Rv3556c;product=Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase);note=FunctionalCategory: lipid metabolism chr1 CDS 3997029 3997631 . - . ID=CDS1;locus_tag=Rv3557c;product=Transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 3997980 3999638 . + . ID=CDS1;locus_tag=Rv3558;gene=PPE64;product=PPE family protein PPE64;note=FunctionalCategory: PE/PPE, potential secreted effector protein, Predicted structural similarity to several secreted autotransporters of E. coli (PDB: 4om9A,1wxrA,3szeA);Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4om9A,1wxrA,3szeA chr1 CDS 3999647 4000435 . - . ID=CDS1;locus_tag=Rv3559c;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4000432 4001589 . - . ID=CDS1;locus_tag=Rv3560c;product=Probable acyl-CoA dehydrogenase FadE30;note=FunctionalCategory: lipid metabolism chr1 CDS 4001637 4003160 . + . ID=CDS1;locus_tag=Rv3561;product=Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 4003161 4004294 . + . ID=CDS1;locus_tag=Rv3562;product=Probable acyl-CoA dehydrogenase FadE31;note=FunctionalCategory: lipid metabolism chr1 CDS 4004291 4005250 . + . ID=CDS1;locus_tag=Rv3563;product=Probable acyl-CoA dehydrogenase FadE32;note=FunctionalCategory: lipid metabolism chr1 CDS 4005247 4006203 . + . ID=CDS1;locus_tag=Rv3564;product=Probable acyl-CoA dehydrogenase FadE33;note=FunctionalCategory: lipid metabolism chr1 CDS 4006200 4007366 . + . ID=CDS1;locus_tag=Rv3565;product=Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4007331 4008182 . - . ID=CDS1;locus_tag=Rv3566c;product=Arylamine N-acetyltransferase Nat (arylamine acetylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4008167 4008433 . - . ID=CDS1;locus_tag=Rv3566A;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4008719 4009282 . - . ID=CDS1;locus_tag=Rv3567c;product=Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase.;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4009297 4010199 . - . ID=CDS1;locus_tag=Rv3568c;product=3,4-DHSA dioxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4010196 4011071 . - . ID=CDS1;locus_tag=Rv3569c;product=4,9-DHSA hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4011086 4012270 . - . ID=CDS1;locus_tag=Rv3570c;product=Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase.;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4012417 4013493 . + . ID=CDS1;locus_tag=Rv3571;product=Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4013511 4014041 . + . ID=CDS1;locus_tag=Rv3572;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4014077 4016212 . - . ID=CDS1;locus_tag=Rv3573c;product=Probable acyl-CoA dehydrogenase FadE34;note=FunctionalCategory: lipid metabolism chr1 CDS 4016484 4017083 . + . ID=CDS1;locus_tag=Rv3574;product=Transcriptional regulatory protein KstR (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 4017089 4018168 . - . ID=CDS1;locus_tag=Rv3575c;product=Transcriptional regulatory protein (probably LacI-family);note=FunctionalCategory: regulatory proteins chr1 CDS 4018358 4019071 . + . ID=CDS1;locus_tag=Rv3576;product=Possible conserved lipoprotein LppH;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4019262 4020128 . + . ID=CDS1;locus_tag=Rv3577;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4020142 4021383 . + . ID=CDS1;locus_tag=Rv3578;product=Possible arsenical pump integral membrane protein ArsB2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4021425 4022393 . - . ID=CDS1;locus_tag=Rv3579c;product=Possible tRNA/rRNA methyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4022394 4023803 . - . ID=CDS1;locus_tag=Rv3580c;product=Cysteinyl-tRNA synthetase 1 CysS1 (cysteine--tRNA ligase 1) (CYSRS 1) (cysteine translase);note=FunctionalCategory: information pathways chr1 CDS 4023868 4024347 . - . ID=CDS1;locus_tag=Rv3581c;product=Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4024344 4025039 . - . ID=CDS1;locus_tag=Rv3582c;product=4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (MEP cytidylyltransferase) (MCT);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4025056 4025544 . - . ID=CDS1;locus_tag=Rv3583c;gene=carD;product=Transcription factor;note=FunctionalCategory: regulatory proteins, Present at most if not all sigma A promoters in mycobacteria. [PMID: 23858468], Binds near the upstream edge of the -10 promoter element and likely facilitates DNA bending and impedes transcription bubble collapse, stabilizing the transcription initiation complex. [PMID: 28067618], Permits increased transcriptional throughput when present alongside RbpA and RNA polymerase than either factor alone with RNAP. [PMID: 27342278], binds directly with promoter DNA and RNA polymerase. [PMID: 27342278] chr1 CDS 4025830 4026378 . + . ID=CDS1;locus_tag=Rv3584;product=Possible conserved lipoprotein LpqE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4026444 4027886 . + . ID=CDS1;locus_tag=Rv3585;product=DNA repair protein RadA (DNA repair protein SMS);note=FunctionalCategory: information pathways chr1 CDS 4027891 4028967 . + . ID=CDS1;locus_tag=Rv3586;gene=dacA;product=diadenylate cyclase (DacA);Experiment=DESCRIPTION:protein expression and purification, High-performance liquid chromatography (HPLC), thin layer chromatography, mass spectrometry, enzyme activity [PMID: 22529992],Experiment=DESCRIPTION:protein expression and purification, enzyme activity assay, Matrix Assisted Laser Desorption/Ionization[PMID: 24465894]/note:FunctionalCategory: conserved hypotheticals/note:Also possesses ATPase activity which is suppressed in the presence of DAC activity and also in the presence of high concentration of ATP [PMID: 24465894];EC_number=2.7.7.85 chr1 CDS 4028968 4029762 . - . ID=CDS1;locus_tag=Rv3587c;product=Probable antigen;Experiment=DESCRIPTION: Electrophoresis, Immunoblotting, liquid chromatography, tandem mass spectrometry. [PMID: 18208443]/note:FunctionalCategory: cell wall and cell processes chr1 CDS 4029871 4030494 . - . ID=CDS1;locus_tag=Rv3588c;product=Beta-carbonic anhydrase CanB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4030493 4031407 . + . ID=CDS1;locus_tag=Rv3589;product=Probable adenine glycosylase MutY;note=FunctionalCategory: information pathways chr1 CDS 4031404 4033158 . - . ID=CDS1;locus_tag=Rv3590c;gene=PE_PGRS58;product=PE-PGRS family protein PE_PGRS58;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection. [PMID: 21085642] chr1 CDS 4033269 4034042 . - . ID=CDS1;locus_tag=Rv3591c;product=Probable esterase;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=DESCRIPTION:protein purification and characterization[PMID: 27050490] chr1 CDS 4034057 4034374 . + . ID=CDS1;locus_tag=Rv3592;product=Possible heme degrading protein MhuD;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4034352 4035710 . + . ID=CDS1;locus_tag=Rv3593;product=Probable conserved lipoprotein LpqF;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4035857 4036684 . + . ID=CDS1;locus_tag=Rv3594;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4036731 4038050 . - . ID=CDS1;locus_tag=Rv3595c;gene=PE_PGRS59;product=PE-PGRS family protein PE_PGRS59;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry. [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection. [PMID: 21085642] chr1 CDS 4038158 4040704 . - . ID=CDS1;locus_tag=Rv3596c;product=Probable ATP-dependent protease ATP-binding subunit ClpC1;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4040981 4041319 . - . ID=CDS1;locus_tag=Rv3597c;product=Iron-regulated H-NS-like protein Lsr2;note=FunctionalCategory: information pathways chr1 CDS 4041423 4042940 . - . ID=CDS1;locus_tag=Rv3598c;product=Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase);note=FunctionalCategory: information pathways chr1 CDS 4042952 4043035 . - . ID=CDS1;locus_tag=Rv3599c;product=Hypothetical short protein;note=FunctionalCategory: unknown chr1 CDS 4043041 4043859 . - . ID=CDS1;locus_tag=Rv3600c;product=Conserved protein/Putative Pantothenate kinase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.1.33 (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0016301/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0015937/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0016310/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A,Ontology_term=0004594/note:identified by similarity of predicted tertiary structure to PDB 3djcG,3bf3A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3djcG,3bf3A chr1 CDS 4043862 4044281 . - . ID=CDS1;locus_tag=Rv3601c;product=Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4044281 4045210 . - . ID=CDS1;locus_tag=Rv3602c;product=Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4045207 4046118 . - . ID=CDS1;locus_tag=Rv3603c;product=Conserved hypothetical alanine and leucine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4046303 4047496 . - . ID=CDS1;locus_tag=Rv3604c;product=Probable conserved transmembrane protein rich in alanine and arginine and proline;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4047705 4048181 . - . ID=CDS1;locus_tag=Rv3605c;product=Probable conserved secreted protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4048181 4048747 . - . ID=CDS1;locus_tag=Rv3606c;product=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4048744 4049145 . - . ID=CDS1;locus_tag=Rv3607c;product=Probable dihydroneopterin aldolase FolB (DHNA);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4049138 4049980 . - . ID=CDS1;locus_tag=Rv3608c;product=Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4049977 4050585 . - . ID=CDS1;locus_tag=Rv3609c;product=GTP cyclohydrolase I FolE (GTP-ch-I);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4050601 4052883 . - . ID=CDS1;locus_tag=Rv3610c;product=Membrane-bound protease FtsH (cell division protein);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4052950 4053603 . + . ID=CDS1;locus_tag=Rv3611;product=Hypothetical arginine and proline rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4053518 4053847 . - . ID=CDS1;locus_tag=Rv3612c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4053881 4054042 . - . ID=CDS1;locus_tag=Rv3613c;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4054142 4054696 . - . ID=CDS1;locus_tag=Rv3614c;product=ESX-1 secretion-associated protein EspD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4054812 4055123 . - . ID=CDS1;locus_tag=Rv3615c;product=ESX-1 secretion-associated protein EspC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4055197 4056375 . - . ID=CDS1;locus_tag=Rv3616c;product=ESX-1 secretion-associated protein A, EspA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4057733 4058701 . + . ID=CDS1;locus_tag=Rv3617;product=Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4058698 4059885 . + . ID=CDS1;locus_tag=Rv3618;product=Possible monooxygenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4059984 4060268 . - . ID=CDS1;locus_tag=Rv3619c;product=Putative ESAT-6 like protein EsxV (ESAT-6 like protein 1);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4060295 4060591 . - . ID=CDS1;locus_tag=Rv3620c;product=Putative ESAT-6 like protein EsxW (ESAT-6 like protein 10);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4060648 4061889 . - . ID=CDS1;locus_tag=Rv3621c;gene=PPE65;product=Antigen;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642],Experiment=DESCRIPTION:ELISA [PMID: 21288992]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642]/note:co-operonic, co-transcribed, and co-translated with Rv3622c (PE32) [PMID: 27242739]/note:suppresses Th1 cytokines in conjunction with PE32 [PMID: 27242739]/note:increases the level of anti-inflammatory cytokine IL-10 [PMID: 27242739] chr1 CDS 4061899 4062198 . - . ID=CDS1;locus_tag=Rv3622c;gene=PE32;product=Probable T-cell Antigen;Experiment=DESCRIPTION: Protein expression and purification, ELISA, MTT assay, Cytokine assay, Flow cytometry for interferon=gamma levels [PMID: 27242739]/note:FunctionalCategory: PE/PPE/note:Possibly involved in modulating anti-mycobacterial host immune response by hampering TH1 response [PMID: 27242739]/note:co-operonic, co-transcribed, and co-translated with Rv3621c (PPE65) [PMID: 27242739]/note:Possibly involved in protein secretion by contributing to overall secretory functioning of the ESX-5 system together with the EsxMN proteins encoded by the parental ESX-5 region [PMID: 26303392,27200304] chr1 CDS 4062527 4063249 . + . ID=CDS1;locus_tag=Rv3623;product=Probable conserved lipoprotein LpqG;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4063254 4063856 . - . ID=CDS1;locus_tag=Rv3624c;product=Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphorylase) (imp diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4063901 4064872 . - . ID=CDS1;locus_tag=Rv3625c;product=Possible cell cycle protein MesJ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4064851 4065903 . - . ID=CDS1;locus_tag=Rv3626c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4065900 4067285 . - . ID=CDS1;locus_tag=Rv3627c;product=Conserved protein/putative serine-type carboxypeptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.16.-;Ontology_term=0004175/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0030288/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0009254/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0046677/note:identified by similarity of predicted tertiary structure to PDB 2wkeA,2ex8A3,2wkeA1,2ex8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wkeA,2ex8A3,2wkeA1,2ex8A,Ontology_term=0042597/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0009252/note:identified by similarity of predicted tertiary structure to PDB 2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A,Ontology_term=0009002/note:identified by similarity of predicted tertiary structure to PDB 2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A,Ontology_term=0008233/note:identified by similarity of predicted tertiary structure to PDB 2wkeA,2wkeA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wkeA,2wkeA1,Ontology_term=0007049/note:identified by similarity of predicted tertiary structure to PDB 1w5dA,1w5dA1,2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w5dA,1w5dA1,2ex8A,2ex8A3,Ontology_term=0016998/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0004180/note:identified by similarity of predicted tertiary structure to PDB 2wkeA,2ex8A3,2wkeA1,2ex8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2wkeA,2ex8A3,2wkeA1,2ex8A,Ontology_term=0004185/note:identified by similarity of predicted tertiary structure to PDB 2ex8A3,1w5dA,3a3iA,2wkeA,1w5dA1,2ex8A,2wkeA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A3,1w5dA,3a3iA,2wkeA,1w5dA1,2ex8A,2wkeA1,Ontology_term=0071555/note:identified by similarity of predicted tertiary structure to PDB 2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A,Ontology_term=0051301/note:identified by similarity of predicted tertiary structure to PDB 1w5dA,1w5dA1,2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w5dA,1w5dA1,2ex8A,2ex8A3,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 2ex8A3,1w5dA,3a3iA,2wkeA,1w5dA1,2ex8A,2wkeA1/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A3,1w5dA,3a3iA,2wkeA,1w5dA1,2ex8A,2wkeA1,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A,Ontology_term=0000270/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0009253/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0008360/note:identified by similarity of predicted tertiary structure to PDB 2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A3,1w5dA,2wkeA,1w5dA1,2wkeA1,2ex8A,Ontology_term=0043093/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0008658/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 1w5dA,1w5dA1,2wkeA1,2wkeA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1w5dA,1w5dA1,2wkeA1,2wkeA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2ex8A,2ex8A3/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ex8A,2ex8A3 chr1 CDS 4067423 4067911 . + . ID=CDS1;locus_tag=Rv3628;product=Inorganic pyrophosphatase Ppa (pyrophosphate phospho-hydrolase) (PPASE) (inorganic diphosphatase) (diphosphate phospho-hydrolase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4067957 4069054 . - . ID=CDS1;locus_tag=Rv3629c;product=Probable conserved integral membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4069175 4070470 . + . ID=CDS1;locus_tag=Rv3630;product=Probable conserved integral membrane protein/putative Na+/H+ antiporter drug efflux protein;note=FunctionalCategory: cell wall and cell processes, Possible multidrug transport protein. [PMID: 25467293], Contains multi-antimicrobial extrusion protein (MatE) domain. [PMID: 25467293], strong structural similarity with two MATE (Multidrug and toxic compound extrusion proteins) transporters, identified by similarity of predicted tertiary structure to PDB 3vvnA,4z3nA,3mktA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3vvnA,4z3nA,3mktA chr1 CDS 4070514 4071239 . + . ID=CDS1;locus_tag=Rv3631;product=Possible transferase (possibly glycosyltransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4071236 4071580 . + . ID=CDS1;locus_tag=Rv3632;product=Putative flippase;Experiment=DESCRIPTION:protein expression and purification, gene knockout, mass spectrometry, capillary electrophoresis [PMID: 21030587]/note:FunctionalCategory: cell wall and cell processes/note:Couples with Rv3631 (ppgS) to increase synthesis rate of polyprenyl-phospho-N-Polishedacetyl-galactosamine from polyprenyl-P and UDP-GalNAc. [PMID: 21030587] chr1 CDS 4071791 4072666 . + . ID=CDS1;locus_tag=Rv3633;product=Conserved protein/putative ester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.14.11.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4y5sA,2rdnA,2a1xA,3emrA,2hbtA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006631/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0005782/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0017000/note:identified by similarity of predicted tertiary structure to PDB 2rdnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,Ontology_term=0019491/note:identified by similarity of predicted tertiary structure to PDB 3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3emrA,Ontology_term=1902181/note:identified by similarity of predicted tertiary structure to PDB 4y5sA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,Ontology_term=0042400/note:identified by similarity of predicted tertiary structure to PDB 3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3emrA,Ontology_term=0048244/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4y5sA,2rdnA,2a1xA,3emrA,2hbtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,2rdnA,2a1xA,3emrA,2hbtA,Ontology_term=0031418/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,2a1xA,2hbtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,2a1xA,2hbtA,Ontology_term=0001561/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0016706/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,3emrA,Ontology_term=0016705/note:identified by similarity of predicted tertiary structure to PDB 2hbtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2hbtA,Ontology_term=0005777/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0005506/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,3emrA,2hbtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,3emrA,2hbtA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2rdnA,2a1xA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,2a1xA,3emrA,Ontology_term=0097089/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0006103/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0006720/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0008198/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0048037/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4y5sA,2rdnA,2a1xA,3emrA,2hbtA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,2rdnA,2a1xA,3emrA,2hbtA,Ontology_term=0051213/note:identified by similarity of predicted tertiary structure to PDB 4y5sA,2rdnA,2a1xA,3emrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4y5sA,2rdnA,2a1xA,3emrA,Ontology_term=1901336/note:identified by similarity of predicted tertiary structure to PDB 2rdnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2rdnA,Ontology_term=0031406/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2a1xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2a1xA chr1 CDS 4072667 4073611 . - . ID=CDS1;locus_tag=Rv3634c;product=UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4073634 4075409 . + . ID=CDS1;locus_tag=Rv3635;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4075752 4076099 . + . ID=CDS1;locus_tag=Rv3636;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4076484 4076984 . + . ID=CDS1;locus_tag=Rv3637;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4076984 4077730 . + . ID=CDS1;locus_tag=Rv3638;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4077884 4078450 . - . ID=CDS1;locus_tag=Rv3639c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4078520 4079749 . - . ID=CDS1;locus_tag=Rv3640c;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4079925 4080560 . - . ID=CDS1;locus_tag=Rv3641c;product=Possible cell filamentation protein Fic;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4080571 4080765 . - . ID=CDS1;locus_tag=Rv3642c;product=putative protein adenylylation inhibitor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3shgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3shgB,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3shgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3shgB,Ontology_term=1900723/note:identified by similarity of predicted tertiary structure to PDB 3shgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3shgB,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3shgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3shgB chr1 CDS 4081160 4081351 . + . ID=CDS1;locus_tag=Rv3643;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4081516 4082721 . - . ID=CDS1;locus_tag=Rv3644c;product=Possible DNA polymerase;note=FunctionalCategory: information pathways chr1 CDS 4082807 4084456 . + . ID=CDS1;locus_tag=Rv3645;product=class III adenylyl cyclase;Experiment=DESCRIPTION: Protein expression and purification, adenylyl cyclases assays [PMID: 15182360]/note:FunctionalCategory: cell wall and cell processes/note:Contains a signal-transduction HAMP domain [PMID: 19923210]/note:putative cAMP receptor protein binding site [PMID: 18022770]/note:essential for survival of H37RvΔponA2 but not wild-type H37Rv [PMID: 27624961];EC_number=4.6.1.1 chr1 CDS 4084453 4087257 . - . ID=CDS1;locus_tag=Rv3646c;product=DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (TOPO I);note=FunctionalCategory: information pathways chr1 CDS 4087610 4088188 . - . ID=CDS1;locus_tag=Rv3647c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4088328 4088531 . - . ID=CDS1;locus_tag=Rv3648c;product=Probable cold shock protein A CspA;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4088781 4091096 . + . ID=CDS1;locus_tag=Rv3649;product=Probable helicase;note=FunctionalCategory: information pathways chr1 CDS 4091233 4091517 . + . ID=CDS1;locus_tag=Rv3650;gene=PE33;product=PE family protein PE33;note=FunctionalCategory: PE/PPE, Predicted cAMP Receptor Protein (CRP) binding site (at position 86) [PMID: 18022770] chr1 CDS 4091841 4092878 . + . ID=CDS1;locus_tag=Rv3651;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4093632 4093946 . + . ID=CDS1;locus_tag=Rv3652;gene=PE_PGRS60;product=PE-PGRS family-related protein PE_PGRS60;note=FunctionalCategory: PE/PPE, Binds fibronectin [PMID: 26158346] chr1 CDS 4093940 4094527 . + . ID=CDS1;locus_tag=Rv3653;gene=PE_PGRS61;product=PE-PGRS family-related protein PE_PGRS61;Experiment=DESCRIPTION:Isothermal titration calorimetry, CaCl2 overlay assay, fluorescence, circular dichroism spectroscopy, mutagenesis, receptor interaction pull-down assays [PMID: 27483162]/note:FunctionalCategory: PE/PPE/note:Induced under manganese (Mn) limitation [PMID: 26337157]/note:Binds Ca-2+ (calcium) during M. smegmatis macrophage infection (involved in host-pathogen interaction) [PMID: 27483162]/note:Binds to Toll-like Receptor 2 (TLR2) in THP-1 macrophages which is mediated by Ca-2+ (calcium) binding [PMID: 27483162]/note:Fibronectin binding protein [PMID: 27872707] chr1 CDS 4094660 4094914 . - . ID=CDS1;locus_tag=Rv3654c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, induced and exported in vivo [PMID: 28442606], suppresses macrophage apoptosis through blocking the extrinsic pathway [PMID: 20454556] chr1 CDS 4094923 4095300 . - . ID=CDS1;locus_tag=Rv3655c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4095324 4095530 . - . ID=CDS1;locus_tag=Rv3656c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4095540 4096115 . - . ID=CDS1;locus_tag=Rv3657c;product=Possible conserved alanine rich membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4096139 4096939 . - . ID=CDS1;locus_tag=Rv3658c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4096936 4097994 . - . ID=CDS1;locus_tag=Rv3659c;product=putative ATPase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.-;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jvvA,Ontology_term=0016887/note:identified by similarity of predicted tertiary structure to PDB 3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jvvA,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 4ihqA,4ihqA2,2oap22,3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ihqA,4ihqA2,2oap22,3jvvA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 4ihqA,4ihqA2,2oap22,3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ihqA,4ihqA2,2oap22,3jvvA,Ontology_term=0043108/note:identified by similarity of predicted tertiary structure to PDB 3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jvvA,Ontology_term=0044096/note:identified by similarity of predicted tertiary structure to PDB 3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jvvA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 4ihqA,4ihqA2/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ihqA,4ihqA2,Ontology_term=0043107/note:identified by similarity of predicted tertiary structure to PDB 3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3jvvA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 4ihqA,4ihqA2,2oap22,3jvvA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4ihqA,4ihqA2,2oap22,3jvvA chr1 CDS 4098096 4099148 . - . ID=CDS1;locus_tag=Rv3660c;product=putative septum site determining protein (Ssd) (a group of FtsZ regulatory proteins);Experiment=DESCRIPTION:structure analysis via scanning electron microscopy, transcriptional profiling, RT-PCR [PMID: 21504606]/inference:alignment:consensus-model sequences [PMID: 21504606]/inference:similar to AA sequence:BLAST [PMID: 21504606]/note:FunctionalCategory: virulence, detoxification, adaptation/note:promotes filamentation [PMID: 21504606]/note:elicits alternative metabolic and dormancy stress response [PMID: 21504606];EC_number=3.6.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bejA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA,Ontology_term=0007059/note:identified by similarity of predicted tertiary structure to PDB 2bejA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bejA chr1 CDS 4099647 4100510 . + . ID=CDS1;locus_tag=Rv3661;product=Conserved hypothetical protein;note=FunctionalCategory: virulence, detoxification, adaptation;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4101265 4102035 . - . ID=CDS1;locus_tag=Rv3662c;product=putative nucleotidyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.7.7.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3eqxA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA,Ontology_term=0070733/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA,Ontology_term=0018117/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3eqxA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3eqxA chr1 CDS 4102032 4103678 . - . ID=CDS1;locus_tag=Rv3663c;product=Probable dipeptide-transport ATP-binding protein ABC transporter DppD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4103675 4104475 . - . ID=CDS1;locus_tag=Rv3664c;product=Probable dipeptide-transport integral membrane protein ABC transporter DppC;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4104531 4105457 . - . ID=CDS1;locus_tag=Rv3665c;product=Probable dipeptide-transport integral membrane protein ABC transporter DppB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4105459 4107084 . - . ID=CDS1;locus_tag=Rv3666c;product=Probable periplasmic dipeptide-binding lipoprotein DppA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4107792 4109747 . + . ID=CDS1;locus_tag=Rv3667;product=Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 4109783 4110145 . - . ID=CDS1;locus_tag=Rv3668c;product=Possible protease;note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4110827 4111345 . + . ID=CDS1;locus_tag=Rv3669;gene=mhpE;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4111346 4112329 . + . ID=CDS1;locus_tag=Rv3670;product=Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase);note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4112322 4113515 . - . ID=CDS1;locus_tag=Rv3671c;product=Membrane-associated serine protease;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4113521 4114342 . - . ID=CDS1;locus_tag=Rv3672c;product=putative acid anhydride phosphatase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3couA,1u20A,1f3yA,1nqzA,1xscA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008284/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0050897/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0008803/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=1990003/note:identified by similarity of predicted tertiary structure to PDB 3couA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,Ontology_term=0016311/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0098519/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0097383/note:identified by similarity of predicted tertiary structure to PDB 3couA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,Ontology_term=0035870/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0008235/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0030515/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=1901639/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0006139/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0005730/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A,1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,1xscA,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0004081/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0050072/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=1901640/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=1901641/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0006402/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0006382/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 3couA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,Ontology_term=0003723/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A,1f3yA,1nqzA,1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,1f3yA,1nqzA,1xscA,Ontology_term=0046709/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0090068/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0030145/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=2000781/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0009117/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0035863/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0034656/note:identified by similarity of predicted tertiary structure to PDB 3couA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,Ontology_term=0006508/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0034599/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0016077/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=2000233/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,Ontology_term=0008796/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A,1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A,1xscA,Ontology_term=0006915/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0003729/note:identified by similarity of predicted tertiary structure to PDB 3couA,1u20A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3couA,1u20A chr1 CDS 4114474 4115157 . - . ID=CDS1;locus_tag=Rv3673c;product=Possible membrane-anchored thioredoxin-like protein (thiol-disulfide interchange related protein);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4115157 4115894 . - . ID=CDS1;locus_tag=Rv3674c;product=Probable endonuclease III Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic));note=FunctionalCategory: information pathways chr1 CDS 4116002 4116379 . + . ID=CDS1;locus_tag=Rv3675;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4116478 4117152 . + . ID=CDS1;locus_tag=Rv3676;product=Transcriptional regulatory protein Crp (Crp/Fnr-family);note=FunctionalCategory: regulatory proteins chr1 CDS 4117258 4118052 . - . ID=CDS1;locus_tag=Rv3677c;product=Possible hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4118059 4118514 . - . ID=CDS1;locus_tag=Rv3678c;product=putative deaminase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.99.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:5hp7A/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.1.-.- (Probable)/note:identified by similarity of predicted tertiary structure to PDB:2cwjA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2cwjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cwjA chr1 CDS 4118530 4118691 . - . ID=CDS1;locus_tag=Rv3678A;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4118776 4119798 . + . ID=CDS1;locus_tag=Rv3679;product=Probable anion transporter ATPase;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4119795 4120955 . + . ID=CDS1;locus_tag=Rv3680;product=Probable anion transporter ATPase;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4121198 4121554 . - . ID=CDS1;locus_tag=Rv3681c;product=Probable transcriptional regulatory protein WhiB-like WhiB4;note=FunctionalCategory: regulatory proteins chr1 CDS 4121916 4124348 . + . ID=CDS1;locus_tag=Rv3682;product=Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)];note=FunctionalCategory: cell wall and cell processes chr1 CDS 4124417 4125376 . + . ID=CDS1;locus_tag=Rv3683;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4125439 4126479 . + . ID=CDS1;locus_tag=Rv3684;product=Probable lyase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4127295 4128725 . - . ID=CDS1;locus_tag=Rv3685c;product=Probable cytochrome P450 137 Cyp137;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4128751 4129083 . - . ID=CDS1;locus_tag=Rv3686c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4129323 4129691 . - . ID=CDS1;locus_tag=Rv3687c;product=Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B);note=FunctionalCategory: information pathways chr1 CDS 4129893 4130357 . - . ID=CDS1;locus_tag=Rv3688c;product=Conserved protein/putative carbon-nitrogen ligase;note=FunctionalCategory: conserved hypotheticals;EC_number=6.3.5.-;Ontology_term=0016884/note:identified by similarity of predicted tertiary structure to PDB 1ng6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ng6A chr1 CDS 4130357 4131712 . + . ID=CDS1;locus_tag=Rv3689;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4131739 4132392 . + . ID=CDS1;locus_tag=Rv3690;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4132518 4133519 . + . ID=CDS1;locus_tag=Rv3691;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4133516 4134592 . + . ID=CDS1;locus_tag=Rv3692;product=Probable methanol dehydrogenase transcriptional regulatory protein MoxR2;note=FunctionalCategory: regulatory proteins chr1 CDS 4134726 4136048 . + . ID=CDS1;locus_tag=Rv3693;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes, potential antigen [PMID: 24564223] chr1 CDS 4136122 4137114 . - . ID=CDS1;locus_tag=Rv3694c;product=Possible conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4137206 4138138 . + . ID=CDS1;locus_tag=Rv3695;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4138202 4139755 . - . ID=CDS1;locus_tag=Rv3696c;product=Probable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4139805 4140242 . - . ID=CDS1;locus_tag=Rv3697c;product=Possible toxin VapC48. Contains PIN domain.;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4140239 4140463 . - . ID=CDS1;locus_tag=Rv3697A;product=Possible antitoxin VapB48;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4140493 4142022 . + . ID=CDS1;locus_tag=Rv3698;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4142044 4142745 . + . ID=CDS1;locus_tag=Rv3699;product=Conserved protein/putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=2.1.1.- (Putative);Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 4necA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4necA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 4necA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4necA chr1 CDS 4142748 4143920 . - . ID=CDS1;locus_tag=Rv3700c;gene=egtE;product=pyridoxal 5-phosphate-binding protein involved in ergothioneine (EGT) biosynthesis;Experiment=DESCRIPTION:liquid chromatography-mass spectrometry (LC-MS), EGT detection using thin-layer chromatography (TLC), qRT-PCR [PMID: 26774486]/inference:similar to DNA sequence:BLAST [PMID: 26229105]/note:FunctionalCategory: intermediary metabolism and respiration/note:homologous to M.smegmatis EgtE [PMID: 26229105]/note:qRT-PCR results show that egtA-egtD (Rv3704c-Rv3701c) are operonic but egtE (Rv3700c) is not [PMID: 26774486];EC_number=2.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3kgxB,2huiA,2ch1A,3caiA,2z9xA/inference:ab initio prediction:I-TASSER:5.1,EC_number=4.4.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3gzcA,1p3wB,1n31A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0051384/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0047300/note:identified by similarity of predicted tertiary structure to PDB 2z9xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2z9xA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3gzcA,1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gzcA,1p3wB,Ontology_term=0031119/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0031071/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0005777/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2ch1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2ch1A,Ontology_term=0009436/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0009000/note:identified by similarity of predicted tertiary structure to PDB 3gzcA,1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gzcA,1p3wB,Ontology_term=0005782/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0001887/note:identified by similarity of predicted tertiary structure to PDB 3gzcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gzcA,Ontology_term=0016597/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3gzcA,1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gzcA,1p3wB,Ontology_term=0040007/note:identified by similarity of predicted tertiary structure to PDB 3caiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3caiA,Ontology_term=0005618/note:identified by similarity of predicted tertiary structure to PDB 3caiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3caiA,Ontology_term=0016829/note:identified by similarity of predicted tertiary structure to PDB 3gzcA,1n31A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gzcA,1n31A,Ontology_term=0006520/note:identified by similarity of predicted tertiary structure to PDB 3gzcA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gzcA,Ontology_term=0046487/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0097163/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0042866/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2huiA,2z9xA,3gzcA,1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2huiA,2z9xA,3gzcA,1p3wB,Ontology_term=0044571/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0018131/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0042803/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0006810/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0007219/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0016226/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2huiA,2ch1A,3caiA,2z9xA,3gzcA,1p3wB,1n31A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2huiA,2ch1A,3caiA,2z9xA,3gzcA,1p3wB,1n31A,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 3caiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3caiA,Ontology_term=0043621/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0043231/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0008453/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2huiA,2ch1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2huiA,2ch1A,Ontology_term=0008483/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2huiA,2z9xA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2huiA,2z9xA,Ontology_term=0051537/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0042853/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0019448/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0051591/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0004760/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2huiA,2ch1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2huiA,2ch1A,Ontology_term=0019265/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2ch1A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2ch1A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 3gzcA,1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3gzcA,1p3wB,Ontology_term=0046724/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0005102/note:identified by similarity of predicted tertiary structure to PDB 3kgxB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1p3wB,Ontology_term=0030170/note:identified by similarity of predicted tertiary structure to PDB 3kgxB,2z9xA,1p3wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3kgxB,2z9xA,1p3wB chr1 CDS 4143951 4144916 . - . ID=CDS1;locus_tag=Rv3701c;gene=egtD;product=histidine methyltransferase EgtD, Probable L-histidine N(alpha)-methyltransferase;Experiment=DESCRIPTION:protein expression and purification, in vitro methyltransferase assay, knockout and complementation [PMID: 26229105]/note:FunctionalCategory: conserved hypotheticals/note:likely involved in ergothioneine biosynthesis [PMID: 26229105]/note:negatively regulated by serine/threonine protein kinase D (PknD)/note:induced and exported in vivo [PMID: 28442606];EC_number=2.1.1.44,EC_number=2.1.1.44 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4uy5A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0006479/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0008276/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0030745/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0052699/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0052707/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A,Ontology_term=0052704/note:identified by similarity of predicted tertiary structure to PDB 4uy5A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4uy5A chr1 CDS 4144913 4145614 . - . ID=CDS1;locus_tag=Rv3702c;product=Probable Gamma-glutamyl hercynylcysteine S-oxide hydrolase/Putative pentosyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.5.1.118 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4zfjA/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.4.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1ecgB,1gph1/inference:ab initio prediction:I-TASSER:5.1,EC_number=2.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2j6hA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004360/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0006541/note:identified by similarity of predicted tertiary structure to PDB 4zfjA,1ecgB,2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,1ecgB,2j6hA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 1ecgB,2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,2j6hA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0006048/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0097367/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1ecgB,2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,2j6hA,Ontology_term=0016811/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,Ontology_term=0016757/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0006164/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0008483/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,Ontology_term=0004044/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0006189/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0052699/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 1ecgB,2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,2j6hA,Ontology_term=0042802/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=1901137/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=1901135/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0006002/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0006487/note:identified by similarity of predicted tertiary structure to PDB 2j6hA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2j6hA,Ontology_term=0009113/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0009116/note:identified by similarity of predicted tertiary structure to PDB 1ecgB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1ecgB,Ontology_term=0052704/note:identified by similarity of predicted tertiary structure to PDB 4zfjA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4zfjA chr1 CDS 4145614 4146891 . - . ID=CDS1;locus_tag=Rv3703c;product=Probable Gamma-glutamyl hercynylcysteine S-oxide synthase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.14.99.50 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:4x8bA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004497/note:identified by similarity of predicted tertiary structure to PDB 4x8bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4x8bA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4x8bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4x8bA,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 4x8bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4x8bA,Ontology_term=0052699/note:identified by similarity of predicted tertiary structure to PDB 4x8bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4x8bA,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 4x8bA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4x8bA chr1 CDS 4146888 4148186 . - . ID=CDS1;locus_tag=Rv3704c;product=Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4148318 4148962 . - . ID=CDS1;locus_tag=Rv3705c;product=Conserved protein/putative extracellular sensor;note=FunctionalCategory: conserved hypotheticals, Potential serine/threonine protein kinase sensor, identified by similarity of predicted tertiary structure to PDB 4esqA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4esqA chr1 CDS 4149091 4149480 . - . ID=CDS1;locus_tag=Rv3705A;product=Conserved hypothetical proline rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4149591 4149902 . - . ID=CDS1;locus_tag=Rv3706c;product=Conserved hypothetical proline rich protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4150030 4151040 . - . ID=CDS1;locus_tag=Rv3707c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals, Shown to be involved in phagosome maturation blocking [PMID: 16322769], induced and exported in vivo [PMID: 28442606] chr1 CDS 4151180 4152217 . - . ID=CDS1;locus_tag=Rv3708c;product=Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (aspartic semialdehyde dehydrogenase) (L-aspartate-beta-semialdehyde dehydrogenase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4152218 4153483 . - . ID=CDS1;locus_tag=Rv3709c;product=Aspartokinase Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha)/ and aspartokinase beta subunit (Ask-beta)];note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4153740 4155674 . + . ID=CDS1;locus_tag=Rv3710;product=2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4155740 4156729 . - . ID=CDS1;locus_tag=Rv3711c;product=Probable DNA polymerase III (epsilon subunit) DnaQ;note=FunctionalCategory: information pathways chr1 CDS 4156981 4158222 . + . ID=CDS1;locus_tag=Rv3712;product=Possible ligase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4158227 4158922 . + . ID=CDS1;locus_tag=Rv3713;product=Possible cobyric acid synthase CobQ2;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4158931 4159821 . - . ID=CDS1;locus_tag=Rv3714c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4159889 4160500 . - . ID=CDS1;locus_tag=Rv3715c;product=Probable recombination protein RecR;note=FunctionalCategory: information pathways chr1 CDS 4160512 4160913 . - . ID=CDS1;locus_tag=Rv3716c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4161048 4161773 . + . ID=CDS1;locus_tag=Rv3717;product=N-acetylmuramyl-L-alanine amidase;Experiment=DESCRIPTION:protein expression and purification, muramyl dipeptide hydrolysis assay, crystallography and X-ray diffraction [PMID: 24019530, PMID: 24311595]/note:FunctionalCategory: conserved hypotheticals/note:zinc-dependent/note:Alternative name: peptidoglycan amidase;EC_number=3.5.1.28 chr1 CDS 4161815 4162258 . - . ID=CDS1;locus_tag=Rv3718c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4162306 4163718 . + . ID=CDS1;locus_tag=Rv3719;product=Conserved protein/putative amide-bond oxidoreductase;note=FunctionalCategory: conserved hypotheticals;EC_number=1.5.99.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0019139/note:identified by similarity of predicted tertiary structure to PDB 3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,2exrA,4o95A,Ontology_term=0009690/note:identified by similarity of predicted tertiary structure to PDB 3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,2exrA,4o95A,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,2exrA,4o95A,Ontology_term=0050660/note:identified by similarity of predicted tertiary structure to PDB 3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,2exrA,4o95A,Ontology_term=0009823/note:identified by similarity of predicted tertiary structure to PDB 2exrA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2exrA,Ontology_term=0005615/note:identified by similarity of predicted tertiary structure to PDB 3dq0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4o95A,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,2exrA,4o95A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,2exrA,4o95A,Ontology_term=0016614/note:identified by similarity of predicted tertiary structure to PDB 3dq0A,2exrA,4o95A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A,2exrA,4o95A,Ontology_term=0005576/note:identified by similarity of predicted tertiary structure to PDB 3dq0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dq0A chr1 CDS 4163736 4164998 . + . ID=CDS1;locus_tag=Rv3720;product=Possible fatty acid synthase;note=FunctionalCategory: lipid metabolism chr1 CDS 4164995 4166731 . - . ID=CDS1;locus_tag=Rv3721c;product=DNA polymerase III (subunit gamma/tau) DnaZ/X;note=FunctionalCategory: information pathways chr1 CDS 4166821 4168128 . - . ID=CDS1;locus_tag=Rv3722c;product=probable serine hydrolase, Probable Aspartate transaminase;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry[PMID: 26853625]/note:FunctionalCategory: conserved hypotheticals,Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359];EC_number=3.1.-.-,EC_number=2.6.1.1 (Probable)/note:identified by similarity of predicted tertiary structure to PDB:3pplA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3pplA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pplA,Ontology_term=0008483/note:identified by similarity of predicted tertiary structure to PDB 3pplA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pplA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 3pplA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pplA,Ontology_term=0080130/note:identified by similarity of predicted tertiary structure to PDB 3pplA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pplA,Ontology_term=0004069/note:identified by similarity of predicted tertiary structure to PDB 3pplA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3pplA chr1 CDS 4168536 4169300 . + . ID=CDS1;locus_tag=Rv3723;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4169467 4169709 . + . ID=CDS1;locus_tag=Rv3724A;product=Probable cutinase precursor [first part] Cut5a;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4169606 4170169 . + . ID=CDS1;locus_tag=Rv3724B;product=Probable cutinase [second part] Cut5b;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4170214 4171143 . + . ID=CDS1;locus_tag=Rv3725;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4171421 4172614 . + . ID=CDS1;locus_tag=Rv3726;product=Possible dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4172955 4174763 . + . ID=CDS1;locus_tag=Rv3727;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4174873 4178070 . + . ID=CDS1;locus_tag=Rv3728;product=Probable conserved two-domain membrane protein;note=FunctionalCategory: cell wall and cell processes, induced by INH, RIF, and EMB [PMID: 20001742] chr1 CDS 4178285 4180615 . + . ID=CDS1;locus_tag=Rv3729;product=Possible transferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4180680 4181720 . - . ID=CDS1;locus_tag=Rv3730c;gene=polD1;product=putative DNA polymerase PolD1;Experiment=DESCRIPTION:purified and cloned from M.smegmatis, polymerase assay, non-homologous end joining assay [PMID: 23198659]/note:has sequence homology with M.sm (84%)/note:FunctionalCategory: conserved hypotheticals;EC_number=2.7.7.7,EC_number=2.7.7.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:4bpuA,2iryA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0000082/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0006260/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0006269/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0006270/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0005654/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0005658/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0003697/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0003896/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0003899/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA,Ontology_term=0032201/note:identified by similarity of predicted tertiary structure to PDB 4bpuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4bpuA chr1 CDS 4181758 4182834 . + . ID=CDS1;locus_tag=Rv3731;product=Possible ATP-dependent DNA ligase LigC (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase);note=FunctionalCategory: information pathways chr1 CDS 4182934 4183992 . + . ID=CDS1;locus_tag=Rv3732;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4184012 4184512 . - . ID=CDS1;locus_tag=Rv3733c;product=putative acid anhydride phosphatase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.6.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1f3yA,1xscA,3dkuA,3grnA,2r5wB,1qvjA,2o1cA,1vc9A,2kdwA,1viqA,5cfiA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0017110/note:identified by similarity of predicted tertiary structure to PDB 3dkuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dkuA,Ontology_term=0000309/note:identified by similarity of predicted tertiary structure to PDB 2r5wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r5wB,Ontology_term=0008803/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0019144/note:identified by similarity of predicted tertiary structure to PDB 1viqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1viqA,Ontology_term=0050779/note:identified by similarity of predicted tertiary structure to PDB 2kdwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2kdwA,Ontology_term=0034353/note:identified by similarity of predicted tertiary structure to PDB 2kdwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2kdwA,Ontology_term=0046654/note:identified by similarity of predicted tertiary structure to PDB 2o1cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2o1cA,Ontology_term=0046656/note:identified by similarity of predicted tertiary structure to PDB 2o1cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2o1cA,Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 2kdwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2kdwA,Ontology_term=0006139/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 2o1cA,1viqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2o1cA,1viqA,Ontology_term=0005739/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0000166/note:identified by similarity of predicted tertiary structure to PDB 1xscA,2r5wB,1vc9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,2r5wB,1vc9A,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2r5wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r5wB,Ontology_term=0004081/note:identified by similarity of predicted tertiary structure to PDB 1xscA,5cfiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,5cfiA,Ontology_term=0005759/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0006402/note:identified by similarity of predicted tertiary structure to PDB 2kdwA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2kdwA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2r5wB,2o1cA,1vc9A,1viqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r5wB,2o1cA,1vc9A,1viqA,Ontology_term=0005525/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1f3yA,1xscA,3dkuA,3grnA,2r5wB,1qvjA,2o1cA,1vc9A,2kdwA,1viqA,5cfiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1f3yA,1xscA,3dkuA,3grnA,2r5wB,1qvjA,2o1cA,1vc9A,2kdwA,1viqA,5cfiA,Ontology_term=0016779/note:identified by similarity of predicted tertiary structure to PDB 2r5wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r5wB,Ontology_term=0006915/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0017111/note:identified by similarity of predicted tertiary structure to PDB 3dkuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dkuA,Ontology_term=0004787/note:identified by similarity of predicted tertiary structure to PDB 3dkuA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dkuA,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 2r5wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r5wB,Ontology_term=0009058/note:identified by similarity of predicted tertiary structure to PDB 2r5wB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2r5wB,Ontology_term=0009408/note:identified by similarity of predicted tertiary structure to PDB 1viqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1viqA,Ontology_term=0034599/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0047631/note:identified by similarity of predicted tertiary structure to PDB 1viqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1viqA,Ontology_term=0016818/note:identified by similarity of predicted tertiary structure to PDB 1vc9A,2kdwA,1viqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vc9A,2kdwA,1viqA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1viqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1viqA,Ontology_term=0008796/note:identified by similarity of predicted tertiary structure to PDB 1xscA,5cfiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,5cfiA,Ontology_term=0008828/note:identified by similarity of predicted tertiary structure to PDB 2o1cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2o1cA,Ontology_term=0005524/note:identified by similarity of predicted tertiary structure to PDB 1vc9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1vc9A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1xscA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1xscA,Ontology_term=0019177/note:identified by similarity of predicted tertiary structure to PDB 2o1cA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2o1cA chr1 CDS 4184526 4185890 . - . ID=CDS1;locus_tag=Rv3734c;product=Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2;note=FunctionalCategory: lipid metabolism chr1 CDS 4186089 4186577 . + . ID=CDS1;locus_tag=Rv3735;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4186634 4187695 . + . ID=CDS1;locus_tag=Rv3736;product=Transcriptional regulatory protein (probably AraC/XylS-family);note=FunctionalCategory: regulatory proteins chr1 CDS 4187699 4189288 . + . ID=CDS1;locus_tag=Rv3737;product=Probable conserved transmembrane protein/putative importer subunit;note=FunctionalCategory: cell wall and cell processes, possible host-mimicking transport protein, perhaps nucleus-localizing, strong structural similarity to multiple eukaryotic RNA transporters, primary nuclear transporters, identified by similarity of predicted tertiary structure to PDB 3w3tA,2x19B,4c0oA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3w3tA,2x19B,4c0oA chr1 CDS 4189285 4190232 . - . ID=CDS1;locus_tag=Rv3738c;gene=PPE66;product=PPE family protein PPE66;Experiment=DESCRIPTION:transposon mutagenesis, cell death assay, chemical inhibition of cell death, bacterial survival assays [PMID: 27931684]/note:FunctionalCategory: PE/PPE/note:the quantity of cell death increases when the gene is knocked out host cells [PMID: 27931684] chr1 CDS 4190284 4190517 . - . ID=CDS1;locus_tag=Rv3739c;gene=PPE67;product=PPE family protein PPE67;note=FunctionalCategory: PE/PPE, Regulated by the MarR family transcription factor Rv1404 [PMID: 26615221] chr1 CDS 4190833 4192179 . - . ID=CDS1;locus_tag=Rv3740c;product=Possible triacylglycerol synthase (diacylglycerol acyltransferase);note=FunctionalCategory: lipid metabolism chr1 CDS 4192179 4192853 . - . ID=CDS1;locus_tag=Rv3741c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4192850 4193245 . - . ID=CDS1;locus_tag=Rv3742c;product=Possible oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4193391 4195373 . - . ID=CDS1;locus_tag=Rv3743c;product=Probable cation transporter P-type ATPase CtpJ;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4195440 4195802 . + . ID=CDS1;locus_tag=Rv3744;product=Metal sensor transcriptional regulator (ArsR-SmtB family);note=FunctionalCategory: regulatory proteins chr1 CDS 4195886 4196098 . - . ID=CDS1;locus_tag=Rv3745c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4196171 4196506 . - . ID=CDS1;locus_tag=Rv3746c;gene=PE34;product=Probable PE family protein PE34 (PE family-related protein);note=FunctionalCategory: PE/PPE, Upregulated by glycine and lysozyme treatment [PMID: 23195184], Regulated by the MarR family transcription factor Rv1404 [PMID: 26615221] chr1 CDS 4196724 4197107 . + . ID=CDS1;locus_tag=Rv3747;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4197236 4197595 . + . ID=CDS1;locus_tag=Rv3748;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4197628 4198137 . - . ID=CDS1;locus_tag=Rv3749c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals;Experiment=al evidence provided [PMID: 24662523] chr1 CDS 4198205 4198597 . - . ID=CDS1;locus_tag=Rv3750c;product=Possible excisionase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4198874 4199089 . + . ID=CDS1;locus_tag=Rv3751;product=Probable integrase (fragment);note=FunctionalCategory: insertion seqs and phages chr1 CDS 4199247 4199705 . - . ID=CDS1;locus_tag=Rv3752c;product=Possible cytidine/deoxycytidylate deaminase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4199721 4200221 . - . ID=CDS1;locus_tag=Rv3753c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4200421 4201326 . + . ID=CDS1;locus_tag=Rv3754;product=Prephenate dehydrogenase TyrA (PDH) (hydroxyphenylpyruvate synthase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4201289 4201888 . - . ID=CDS1;locus_tag=Rv3755c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4201894 4202613 . - . ID=CDS1;locus_tag=Rv3756c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4202610 4203299 . - . ID=CDS1;locus_tag=Rv3757c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4203287 4204417 . - . ID=CDS1;locus_tag=Rv3758c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4204426 4205373 . - . ID=CDS1;locus_tag=Rv3759c;product=Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4205487 4205840 . + . ID=CDS1;locus_tag=Rv3760;product=Possible conserved membrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4205862 4206917 . - . ID=CDS1;locus_tag=Rv3761c;product=Possible acyl-CoA dehydrogenase FadE36;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4206996 4208876 . - . ID=CDS1;locus_tag=Rv3762c;product=Possible hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4209047 4209526 . + . ID=CDS1;locus_tag=Rv3763;gene=LpqH;product=bifunctional adhesin/antigen LpqH;Experiment=DESCRIPTION:culture filtrate biotinylation, immunoblotting, gel electrophoresis, M.smegmatis transfection and overexpression, cell-binding and adherence assays, immunostaining [PMID:16098710]/note:FunctionalCategory: cell wall and cell processes/note:Binds mannose receptor of THP-1 monocytes [PMID:16098710]/note:Induces apoptosis of monocyte-derived macrophage and THP-1 cells [PMID:12594264]/note:Induction of macrophage apoptosis is mediated through by Toll-like receptor and is caspase-8 dependent but caspase-9 independent [PMID:12594264] chr1 CDS 4209582 4211009 . - . ID=CDS1;locus_tag=Rv3764c;product=Possible two component sensor kinase TcrY;note=FunctionalCategory: regulatory proteins chr1 CDS 4211080 4211784 . - . ID=CDS1;locus_tag=Rv3765c;product=Probable two component transcriptional regulatory protein TcrX;note=FunctionalCategory: regulatory proteins chr1 CDS 4212293 4212982 . + . ID=CDS1;locus_tag=Rv3766;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4212996 4213940 . - . ID=CDS1;locus_tag=Rv3767c;product=Possible S-adenosylmethionine-dependent methyltransferase;note=FunctionalCategory: lipid metabolism chr1 CDS 4214070 4214429 . + . ID=CDS1;locus_tag=Rv3768;product=putative ether hydrolase/putative alkene transposase;note=FunctionalCategory: conserved hypotheticals;EC_number=5.3.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1e3vB/inference:ab initio prediction:I-TASSER:5.1,EC_number=3.3.2.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2bngC,1nu3B,5aifA,5aihA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0004301/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0018744/note:identified by similarity of predicted tertiary structure to PDB 1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1nu3B,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2bngC,1nu3B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,1nu3B,Ontology_term=0033963/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0006629/note:identified by similarity of predicted tertiary structure to PDB 1e3vB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e3vB,Ontology_term=0005886/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0008202/note:identified by similarity of predicted tertiary structure to PDB 1e3vB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e3vB,Ontology_term=0016853/note:identified by similarity of predicted tertiary structure to PDB 1e3vB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e3vB,Ontology_term=0097176/note:identified by similarity of predicted tertiary structure to PDB 2bngC/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2bngC,Ontology_term=0004769/note:identified by similarity of predicted tertiary structure to PDB 1e3vB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1e3vB chr1 CDS 4214615 4214887 . + . ID=CDS1;locus_tag=Rv3769;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4215200 4215775 . - . ID=CDS1;locus_tag=Rv3770c;product=putative light-activated ion channel protein;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A,Ontology_term=0018298/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A,Ontology_term=0007602/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A,Ontology_term=0034220/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A,Ontology_term=0010461/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A,Ontology_term=0006811/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A,Ontology_term=0005216/note:identified by similarity of predicted tertiary structure to PDB 4jq6A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4jq6A chr1 CDS 4215881 4216063 . - . ID=CDS1;locus_tag=Rv3770A;product=Probable remnant of a transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4216078 4216269 . - . ID=CDS1;locus_tag=Rv3770B;product=Probable remnant of a transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4216404 4216730 . - . ID=CDS1;locus_tag=Rv3771c;product=putative transcription factor;note=FunctionalCategory: conserved hypotheticals;Ontology_term=0003700/note:identified by similarity of predicted tertiary structure to PDB 2q24B/inference:ab initio prediction:I-TASSER:5.1/note:identified by similarity of predicted tertiary structure to PDB 2iubG/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2iubGence/inference:alignment:TM-align:PDB:2q24B,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 2q24B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q24B,Ontology_term=0006355/note:identified by similarity of predicted tertiary structure to PDB 2q24B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q24B,Ontology_term=0000976/note:identified by similarity of predicted tertiary structure to PDB 2q24B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q24B,Ontology_term=0006351/note:identified by similarity of predicted tertiary structure to PDB 2q24B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q24B,Ontology_term=0003677/note:identified by similarity of predicted tertiary structure to PDB 2q24B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2q24B chr1 CDS 4217134 4218195 . + . ID=CDS1;locus_tag=Rv3772;product=Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4218241 4218825 . - . ID=CDS1;locus_tag=Rv3773c;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4218849 4219673 . + . ID=CDS1;locus_tag=Rv3774;product=Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase);note=FunctionalCategory: lipid metabolism chr1 CDS 4219685 4220932 . + . ID=CDS1;locus_tag=Rv3775;product=Probable lipase LipE;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4221089 4222648 . + . ID=CDS1;locus_tag=Rv3776;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4222694 4223680 . + . ID=CDS1;locus_tag=Rv3777;product=Probable oxidoreductase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4223699 4224895 . - . ID=CDS1;locus_tag=Rv3778c;product=Possible aminotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4224985 4226985 . + . ID=CDS1;locus_tag=Rv3779;product=;Experiment=DESCRIPTION:gene knockout and complementation, capillary electrophoresis, enzymatic assays, MALDI-TOF/MS, MS/MS [PMID: 21030587],Experiment=DESCRIPTION:plasmid transformation in M.smegmatis, overexpression, TLC autoradiography, enzyme activity assays [PMID: 19717608]/note:FunctionalCategory: cell wall and cell processes;EC_number=2.4.1.-,EC_number=s are 2.4.1.-, that is not a typo. chr1 CDS 4226989 4227525 . + . ID=CDS1;locus_tag=Rv3780;gene=pafE;product=proteasome accessory factor E (PafE);Experiment=DESCRIPTION:cloning, expression and purification from H37Rv, protein interaction study, proteasome competition assay [PMID: 25469515],Experiment=DESCRIPTION:size-exclusion chromatography with multi-angle light scattering [PMID: 25831519],Experiment=DESCRIPTION:isothermal titration calorimetry, cryo-electron microscopy (cryo-EM), X-ray crystallography [PMID: 27001842]/note:forms active dodecameric ring complex with 12-fold symmetry [PMID: 27001842]/note:Also referred to as bpa (bacterial proteasome activator) [PMID: 25469515]/note:Promotes degradation of heat shock protein repressor (HspR) [PMID: 25831519]/note:FunctionalCategory: conserved hypotheticals;EC_number=6.3.2.- chr1 CDS 4227529 4228350 . + . ID=CDS1;locus_tag=Rv3781;product=Probable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4228347 4229261 . + . ID=CDS1;locus_tag=Rv3782;product=UDP-galactofuranosyl transferase GlfT1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4229258 4230100 . + . ID=CDS1;locus_tag=Rv3783;product=Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4230256 4231236 . + . ID=CDS1;locus_tag=Rv3784;product=Possible dTDP-glucose 4,6-dehydratase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4231320 4232393 . + . ID=CDS1;locus_tag=Rv3785;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4232374 4233597 . - . ID=CDS1;locus_tag=Rv3786c;product=Unknown protein/Putative peptidase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.4.-.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2gu1A/inference:ab initio prediction:I-TASSER:5.1 chr1 CDS 4233610 4234536 . - . ID=CDS1;locus_tag=Rv3787c;product=putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 2ckdA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2ckdA chr1 CDS 4234780 4235265 . + . ID=CDS1;locus_tag=Rv3788;product=probable secondary channel binding-factor of RNA polymerase;Experiment=DESCRIPTION:protein purification, Ni-NTA pulldown assays, transcription and electrophoretic mobility shift assays, Western blotting[PMID: 22194445]/note:FunctionalCategory: conserved hypotheticals/note:prevents nucleotide addition, inhibits transcription [PMID: 22194445] chr1 CDS 4235374 4235739 . + . ID=CDS1;locus_tag=Rv3789;product=GTRA family protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4235773 4237164 . + . ID=CDS1;locus_tag=Rv3790;product=Decaprenylphosphoryl-beta-D-ribose 2'-oxidase;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4237165 4237929 . + . ID=CDS1;locus_tag=Rv3791;product=Decaprenylphosphoryl-D-2-keto erythro pentose reductase;note=FunctionalCategory: lipid metabolism chr1 CDS 4237932 4239863 . + . ID=CDS1;locus_tag=Rv3792;product=Arabinofuranosyltransferase AftA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4239863 4243147 . + . ID=CDS1;locus_tag=Rv3793;product=Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4243233 4246517 . + . ID=CDS1;locus_tag=Rv3794;product=Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4246514 4249810 . + . ID=CDS1;locus_tag=Rv3795;product=Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4249878 4251005 . + . ID=CDS1;locus_tag=Rv3796;product=Conserved protein/putative 5'-Phosphomonoester producing endoribonuclease;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.26.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2cbnA,2fk6A,2e7yA,3zwfA/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0005737/note:identified by similarity of predicted tertiary structure to PDB 3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3zwfA,Ontology_term=0004527/note:identified by similarity of predicted tertiary structure to PDB 2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,Ontology_term=0042781/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,2e7yA,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,2e7yA,3zwfA,Ontology_term=0034414/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,2e7yA,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,2e7yA,3zwfA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,2e7yA,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,2e7yA,3zwfA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,3zwfA,Ontology_term=0008033/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,3zwfA,Ontology_term=0016891/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,3zwfA,Ontology_term=0042779/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,3zwfA,Ontology_term=0090502/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,3zwfA,Ontology_term=0090503/note:identified by similarity of predicted tertiary structure to PDB 2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,Ontology_term=0004518/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,3zwfA,Ontology_term=0004519/note:identified by similarity of predicted tertiary structure to PDB 2cbnA,2fk6A,3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,2fk6A,3zwfA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3zwfA,Ontology_term=0004532/note:identified by similarity of predicted tertiary structure to PDB 2cbnA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2cbnA,Ontology_term=0005634/note:identified by similarity of predicted tertiary structure to PDB 3zwfA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3zwfA chr1 CDS 4251085 4252866 . + . ID=CDS1;locus_tag=Rv3797;product=Probable acyl-CoA dehydrogenase FadE35;note=FunctionalCategory: lipid metabolism chr1 CDS 4252993 4254327 . + . ID=CDS1;locus_tag=Rv3798;product=Probable transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4254380 4255948 . - . ID=CDS1;locus_tag=Rv3799c;product=Probable propionyl-CoA carboxylase beta chain 4 AccD4 (pccase) (propanoyl-CoA:carbon dioxide ligase);note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4255945 4261146 . - . ID=CDS1;locus_tag=Rv3800c;product=Polyketide synthase Pks13;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4261153 4263066 . - . ID=CDS1;locus_tag=Rv3801c;product=Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity.;note=FunctionalCategory: lipid metabolism chr1 CDS 4263355 4264365 . - . ID=CDS1;locus_tag=Rv3802c;gene=clp6;product=bifunctional phospholipase acylhydrolase/thioesterase;note=FunctionalCategory: cell wall and cell processes;Experiment=DESCRIPTION:Protein expression and purification, click-chemistry activity-based probe, liquid chromatography Mass Spectrometry [PMID: 26853625],Experiment=DESCRIPTION:expression and enzymatic assays in E.coli, isotope-labelling and TLC, [PMID: 19169353],Experiment=DESCRIPTION:enzyme purification from M.smegmatis, gel electrophoresis, substrate radiolabelling, Mass spectrometry [PMID: 17416658]/inference:ab initio prediction:PHYRE [PMID: 26853625]/note:no activity on acetyl-CoA and no acyltransferase activity [PMID: 19169353]/note:has a higher affinity for hexadecanoyl than decanoyl thioesters. [PMID: 19169353]/note:hydrolyzes phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine, and palmitic and arachidonic acid containing phospholipids, but not sphingomyelin [PMID: 19169353]/note:thioesterase activity inhibited by tetrahydrolipstatin [PMID: 19169353]/note:is involved in mycolic acid synthesis/note:also known as cup6;EC_number=? It could be argued to be classified as 3.1.1.4, 3.1.1.32, or 3.1.1.74, but none of those truly describe its activity profile, despite having full EC,EC_number=3.1.1.32,EC_number=3.1.2.- chr1 CDS 4264563 4265462 . - . ID=CDS1;locus_tag=Rv3803c;product=Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C);note=FunctionalCategory: lipid metabolism chr1 CDS 4265642 4266658 . - . ID=CDS1;locus_tag=Rv3804c;product=Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A);note=FunctionalCategory: lipid metabolism chr1 CDS 4266953 4268836 . - . ID=CDS1;locus_tag=Rv3805c;product=Possible arabinofuranosyltransferase AftB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4268925 4269833 . - . ID=CDS1;locus_tag=Rv3806c;product=Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase (decaprenyl-phosphate 5-phosphoribosyltransferase);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4269840 4270337 . - . ID=CDS1;locus_tag=Rv3807c;product=Putative decaprenylphosphoryl-β-d-5-phosphoribose phosphatase;Experiment=DESCRIPTION:purification and expression of M.smegmatis homolog, TLC, ESI-MS, colorimetric phosphate group detection [PMID: 25223716],Experiment=DESCRIPTION:purification and expression in M.tuberculosis [PMID: 24426166]/note:FunctionalCategory: cell wall and cell processes;EC_number=3.1.3.-,EC_number=3.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:2akcB,1eoiA,4px7A/inference:ab initio prediction:I-TASSER:5.1,EC_number=1.11.1.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1qhbA,5aa6A,3w35A,4citA,1qi9A/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0016311/note:identified by similarity of predicted tertiary structure to PDB 2akcB,4px7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2akcB,4px7A,Ontology_term=0008962/note:identified by similarity of predicted tertiary structure to PDB 4px7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4px7A,Ontology_term=0004601/note:identified by similarity of predicted tertiary structure to PDB 1qhbA,5aa6A,3w35A,4citA,1qi9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhbA,5aa6A,3w35A,4citA,1qi9A,Ontology_term=0030288/note:identified by similarity of predicted tertiary structure to PDB 2akcB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2akcB,Ontology_term=0016491/note:identified by similarity of predicted tertiary structure to PDB 1qhbA,4citA,1qi9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhbA,4citA,1qi9A,Ontology_term=0016021/note:identified by similarity of predicted tertiary structure to PDB 4px7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4px7A,Ontology_term=0016020/note:identified by similarity of predicted tertiary structure to PDB 4px7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4px7A,Ontology_term=0098869/note:identified by similarity of predicted tertiary structure to PDB 1qhbA,5aa6A,4citA,1qi9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhbA,5aa6A,4citA,1qi9A,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1qhbA,1qi9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhbA,1qi9A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 2akcB,4px7A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2akcB,4px7A,Ontology_term=0055114/note:identified by similarity of predicted tertiary structure to PDB 1qhbA,5aa6A,3w35A,4citA,1qi9A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1qhbA,5aa6A,3w35A,4citA,1qi9A,Ontology_term=0003993/note:identified by similarity of predicted tertiary structure to PDB 2akcB,1eoiA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2akcB,1eoiA chr1 CDS 4270366 4272279 . - . ID=CDS1;locus_tag=Rv3808c;product=Bifunctional UDP-galactofuranosyl transferase GlfT2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4272276 4273475 . - . ID=CDS1;locus_tag=Rv3809c;product=UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4273739 4274593 . + . ID=CDS1;locus_tag=Rv3810;product=Exported repetitive protein precursor PirG (cell surface protein) (EXP53);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4274798 4276417 . + . ID=CDS1;locus_tag=Rv3811;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4276571 4278085 . + . ID=CDS1;locus_tag=Rv3812;gene=PE_PGRS62;product=T cell antigen;Experiment=DESCRIPTION:Protein expression and purification, western blot, ELISA, cytokine assay, flow cytometry [PMID: 17709160],Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Binds to Toll-like receptor 2 (TLR2) and induces strong dendritic cell-mediated interferon gamma response [PMID: 23788727]/note:Inhibits viability of ANA-1 murine macrophage when expressed in M. smegmatis [PMID: 20221673]/note:Impacts phagosome maturation in host cells [PMID: 22658664]/note:Shows high affinity to MHC H-2kd and low dissociation rate of peptide-MHC complexes [PMID: 18719176]/note:Decreases mRNA expression of pro-inflammatory cytokines IL-1B, IL-6, and iNOS in macrophage [PMID: 20221673]/note:Expressed in vivo in guinea pig lung at both 30 and 90 days post-infection [PMID: 21085642] chr1 CDS 4278394 4279215 . - . ID=CDS1;locus_tag=Rv3813c;product=Conserved protein/putative phosphatase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.3.-;Ontology_term=0050308/note:identified by similarity of predicted tertiary structure to PDB 1rkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rkqA,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1rkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rkqA,Ontology_term=0016791/note:identified by similarity of predicted tertiary structure to PDB 1rkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rkqA,Ontology_term=0016311/note:identified by similarity of predicted tertiary structure to PDB 1rkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rkqA,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1rkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rkqA,Ontology_term=0000287/note:identified by similarity of predicted tertiary structure to PDB 1rkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rkqA,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1rkqA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1rkqA chr1 CDS 4279230 4280015 . - . ID=CDS1;locus_tag=Rv3814c;product=Possible acyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4280033 4280788 . - . ID=CDS1;locus_tag=Rv3815c;product=Possible acyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4280792 4281571 . - . ID=CDS1;locus_tag=Rv3816c;product=Possible acyltransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4281647 4282402 . + . ID=CDS1;locus_tag=Rv3817;product=Possible phosphotransferase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4282449 4283999 . + . ID=CDS1;locus_tag=Rv3818;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4283996 4284331 . + . ID=CDS1;locus_tag=Rv3819;product=Unknown protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4284419 4285825 . - . ID=CDS1;locus_tag=Rv3820c;product=Possible conserved polyketide synthase associated protein PapA2;note=FunctionalCategory: lipid metabolism;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4285973 4286686 . + . ID=CDS1;locus_tag=Rv3821;gene=sap;product=Probable sulfolipid-1-addressing protein (Sap);Experiment=DESCRIPTION:gene disruption, mass spectrometry, thin-layer chromatography, enzymatic activity assays, metabolic labeling[PMID: 22194604]/note:FunctionalCategory: cell wall and cell processes/note:Conserved integral membrane protein [TubercuList]/note:Sap modulates transmembrane transport of SL-1 chr1 CDS 4286721 4287935 . + . ID=CDS1;locus_tag=Rv3822;gene=chp1;product=acyltransferase;Experiment=DESCRIPTION:C-terminal fused cytosol-dependent GFP-fluorescence, [PMID: 25124040],Experiment=DESCRIPTION:gene disruption, mass spectrometry, thin-layer chromatography, enzymatic activity assays[PMID: 22194604]/note:FunctionalCategory: conserved hypotheticals/note:catalyzes successive acyl transfers necessary for SL-1 (sulfolipid-1) synthesis [PMID: 22194604]/note:Reaction carried out on cytosolic side of membrane [PMID: 25124040];EC_number=2.3.1.- chr1 CDS 4288260 4291529 . - . ID=CDS1;locus_tag=Rv3823c;product=Conserved integral membrane transport protein MmpL8;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4291639 4293174 . - . ID=CDS1;locus_tag=Rv3824c;product=Conserved polyketide synthase associated protein PapA1;note=FunctionalCategory: lipid metabolism chr1 CDS 4293225 4299605 . - . ID=CDS1;locus_tag=Rv3825c;product=Polyketide synthase Pks2;note=FunctionalCategory: lipid metabolism chr1 CDS 4299812 4301566 . + . ID=CDS1;locus_tag=Rv3826;product=Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase);note=FunctionalCategory: lipid metabolism chr1 CDS 4301563 4302789 . - . ID=CDS1;locus_tag=Rv3827c;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4302786 4303397 . - . ID=CDS1;locus_tag=Rv3828c;product=Possible resolvase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4303398 4305008 . - . ID=CDS1;locus_tag=Rv3829c;product=Probable dehydrogenase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4305056 4305685 . - . ID=CDS1;locus_tag=Rv3830c;product=Transcriptional regulatory protein (probably TetR-family);note=FunctionalCategory: regulatory proteins chr1 CDS 4305757 4306239 . + . ID=CDS1;locus_tag=Rv3831;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4306236 4306811 . - . ID=CDS1;locus_tag=Rv3832c;product=Conserved protein/putative methyltransferase;note=FunctionalCategory: conserved hypotheticals;EC_number=2.1.1.-;Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 3uj6A,3ou2A,5egpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uj6A,3ou2A,5egpA,Ontology_term=0051539/note:identified by similarity of predicted tertiary structure to PDB 3uj6A,3ou2A,5egpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uj6A,3ou2A,5egpA,Ontology_term=0051536/note:identified by similarity of predicted tertiary structure to PDB 3uj6A,3ou2A,5egpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uj6A,3ou2A,5egpA,Ontology_term=0016740/note:identified by similarity of predicted tertiary structure to PDB 3uj6A,3ou2A,4pneA,5bszA,5egpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uj6A,3ou2A,4pneA,5bszA,5egpA,Ontology_term=0008152/note:identified by similarity of predicted tertiary structure to PDB 4pneA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4pneA,Ontology_term=0008168/note:identified by similarity of predicted tertiary structure to PDB 3uj6A,3ou2A,4pneA,5bszA,5egpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uj6A,3ou2A,4pneA,5bszA,5egpA,Ontology_term=0032259/note:identified by similarity of predicted tertiary structure to PDB 3uj6A,3ou2A,4pneA,5bszA,5egpA/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3uj6A,3ou2A,4pneA,5bszA,5egpA chr1 CDS 4306867 4307658 . + . ID=CDS1;locus_tag=Rv3833;product=Transcriptional regulatory protein (probably AraC-family);note=FunctionalCategory: regulatory proteins chr1 CDS 4307655 4308914 . - . ID=CDS1;locus_tag=Rv3834c;product=SERYL-tRNA synthetase SerS (serine--tRNA ligase) (SERRS) (serine translase);note=FunctionalCategory: information pathways chr1 CDS 4309047 4310396 . + . ID=CDS1;locus_tag=Rv3835;product=Conserved membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4310401 4310814 . + . ID=CDS1;locus_tag=Rv3836;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4311009 4311707 . - . ID=CDS1;locus_tag=Rv3837c;product=Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4311704 4312669 . - . ID=CDS1;locus_tag=Rv3838c;product=Prephenate dehydratase PheA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4312765 4313541 . + . ID=CDS1;locus_tag=Rv3839;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4313567 4313980 . + . ID=CDS1;locus_tag=Rv3840;product=Possible transcriptional regulatory protein/Probable transcriptional regulator;note=FunctionalCategory: regulatory proteins, identified by similarity of predicted tertiary structure to PDB 3qfiA,3mejA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3qfiA,3mejA chr1 CDS 4314178 4314723 . + . ID=CDS1;locus_tag=Rv3841;product=Bacterioferritin BfrB;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4314738 4315562 . - . ID=CDS1;locus_tag=Rv3842c;product=Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase);note=FunctionalCategory: intermediary metabolism and respiration;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4315568 4316596 . - . ID=CDS1;locus_tag=Rv3843c;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4318775 4319266 . + . ID=CDS1;locus_tag=Rv3844;product=Possible transposase;note=FunctionalCategory: insertion seqs and phages chr1 CDS 4319281 4319640 . + . ID=CDS1;locus_tag=Rv3845;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4320704 4321327 . + . ID=CDS1;locus_tag=Rv3846;product=Superoxide dismutase [FE] SodA;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4321538 4322071 . + . ID=CDS1;locus_tag=Rv3847;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4322326 4323234 . + . ID=CDS1;locus_tag=Rv3848;product=Probable conserved transmembrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4323499 4323897 . + . ID=CDS1;locus_tag=Rv3849;product=ESX-1 transcriptional regulatory protein EspR;note=FunctionalCategory: regulatory proteins chr1 CDS 4324015 4324671 . + . ID=CDS1;locus_tag=Rv3850;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4324683 4324967 . + . ID=CDS1;locus_tag=Rv3851;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4325074 4325478 . + . ID=CDS1;locus_tag=Rv3852;product=Possible histone-like protein Hns;note=FunctionalCategory: information pathways chr1 CDS 4325495 4325968 . + . ID=CDS1;locus_tag=Rv3853;product=Regulator of RNase E activity a RraA;note=FunctionalCategory: regulatory proteins chr1 CDS 4326004 4327473 . - . ID=CDS1;locus_tag=Rv3854c;product=Monooxygenase EthA;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4327549 4328199 . + . ID=CDS1;locus_tag=Rv3855;product=Transcriptional regulatory repressor protein (TetR-family) EthR;note=FunctionalCategory: regulatory proteins chr1 CDS 4328401 4329408 . - . ID=CDS1;locus_tag=Rv3856c;product=putative phosphoric monoester hydrolase;note=FunctionalCategory: conserved hypotheticals;EC_number=3.1.3.- (Putative)/note:identified by similarity of predicted tertiary structure to PDB:1pb0A,3dcpA,2yxoB/inference:ab initio prediction:I-TASSER:5.1;Ontology_term=0008270/note:identified by similarity of predicted tertiary structure to PDB 1pb0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,Ontology_term=0004401/note:identified by similarity of predicted tertiary structure to PDB 3dcpA,2yxoB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dcpA,2yxoB,Ontology_term=0046872/note:identified by similarity of predicted tertiary structure to PDB 1pb0A,2yxoB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,2yxoB,Ontology_term=0005829/note:identified by similarity of predicted tertiary structure to PDB 1pb0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,Ontology_term=0016787/note:identified by similarity of predicted tertiary structure to PDB 1pb0A,2yxoB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,2yxoB,Ontology_term=0003824/note:identified by similarity of predicted tertiary structure to PDB 1pb0A,3dcpA,2yxoB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,3dcpA,2yxoB,Ontology_term=0071978/note:identified by similarity of predicted tertiary structure to PDB 1pb0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,Ontology_term=0016311/note:identified by similarity of predicted tertiary structure to PDB 2yxoB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:2yxoB,Ontology_term=0042578/note:identified by similarity of predicted tertiary structure to PDB 1pb0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,Ontology_term=0005515/note:identified by similarity of predicted tertiary structure to PDB 1pb0A/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:1pb0A,Ontology_term=0000105/note:identified by similarity of predicted tertiary structure to PDB 3dcpA,2yxoB/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3dcpA,2yxoB chr1 CDS 4329417 4329614 . - . ID=CDS1;locus_tag=Rv3857c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4330039 4331505 . - . ID=CDS1;locus_tag=Rv3858c;product=Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH)) (GLTS beta chain) (NADPH-GOGAT);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4331498 4336081 . - . ID=CDS1;locus_tag=Rv3859c;product=Probable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH))(NADPH-GOGAT);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4336777 4337949 . + . ID=CDS1;locus_tag=Rv3860;product=Conserved protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4337946 4338272 . + . ID=CDS1;locus_tag=Rv3861;product=Hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4338171 4338521 . - . ID=CDS1;locus_tag=Rv3862c;product=Possible transcriptional regulatory protein WhiB-like WhiB6;note=FunctionalCategory: regulatory proteins chr1 CDS 4339215 4340027 . + . ID=CDS1;locus_tag=Rv3863;product=Unknown alanine rich protein;note=FunctionalCategory: conserved hypotheticals;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4340270 4341478 . + . ID=CDS1;locus_tag=Rv3864;product=ESX-1 secretion-associated protein EspE;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4341566 4341877 . + . ID=CDS1;locus_tag=Rv3865;product=ESX-1 secretion-associated protein EspF;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4341880 4342731 . + . ID=CDS1;locus_tag=Rv3866;product=ESX-1 secretion-associated protein EspG1;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4342770 4343321 . + . ID=CDS1;locus_tag=Rv3867;product=ESX-1 secretion-associated protein EspH;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4343314 4345035 . + . ID=CDS1;locus_tag=Rv3868;product=ESX conserved component EccA1. ESX-1 type VII secretion system protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4345039 4346481 . + . ID=CDS1;locus_tag=Rv3869;product=ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4346481 4348724 . + . ID=CDS1;locus_tag=Rv3870;product=ESX conserved component EccCa1. ESX-1 type VII secretion system protein. Possible transmembrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4348827 4350602 . + . ID=CDS1;locus_tag=Rv3871;product=ESX conserved component EccCb1. ESX-1 type VII secretion system protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4350745 4351044 . + . ID=CDS1;locus_tag=Rv3872;gene=PE35;product=T-Cell Antigen;Experiment=DESCRIPTION:Protein expression and purification, western blot, ELISA [PMID: 17328726],Experiment=EXISTENCE:Label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:2-dimensional gel electrophoresis, liquid chromatography mass spectrometry [PMID: 17443846],Experiment=EXISTENCE:Gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:Present in the RD1 locus [PMID: 24467650]/note:Pairs with Rv3873 to interact with TLR2 to increase cytokine secretion [PMID: 24467650]/note:Interacts with Rv3873 to activate p38 and ERK1/2 pathways to induce IL-10 production [PMID: 24467650]/note:Interacts with Rv3872 to induce MCP-1 production [PMID: 24467650]/note:Physically interacts with TLR2 resulting in a dose dependent increase in the secretion of pro-inflammatory cytokine secretion [PMID: 24467650]/note:Probably secreted, found expressed in the culture filtrate [PMID: 17443846,21920479]/note:Absent from membrane and whole-cell lysate [PMID: 21920479]/note:Found in the cell membrane [PMID: 21261938] chr1 CDS 4351075 4352181 . + . ID=CDS1;locus_tag=Rv3873;gene=PPE68;product=T-cell Antigen;Experiment=DESCRIPTION:RT-PCR, Protein expression and purification, PBMC cell culture, IFN-y assay [PMID: 14573626],Experiment=EXISTENCE:Label-free quantitative proteomics, mass spectrometry [PMID: 21261938],Experiment=EXISTENCE:Gel electrophoresis, liquid chromatography mass spectrometry, label-free quantitation [PMID: 21920479]/note:FunctionalCategory: PE/PPE/note:Present in the RD1 locus [PMID: 24467650]/note:Interacts with Rv3872 to activate p38 and ERK1/2 pathways to induce IL-10 production [PMID: 24467650]/note:Interacts with Rv3872 to induce MCP-1 production [PMID: 24467650]/note:Pairs with Rv3873 to interact with TLR2 to increase cytokine secretion [PMID: 24467650]/note:Pairs with Rv3872 to interact with TLR2 and regulate immunomodulatory mechanism [PMID: 24467650]/note:Located in membrane and cell wall of M.tuberculosis [PMID: 15039340]/note:PPE68-Rv2626c complex plays an important role in host cell necrosis and contributes to the escape of Mtb from the infected macrophage [PMID: 26605779]/note:Located in the cell membrane [PMID: 21920479,21261938],Experiment=ally [PMID: 21920479]/note:Found in whole-cell lysate [PMID: 21920479]/note:Th1 cells that respond strongly to this protein also respond to CFP10/ESAT-6 [PMID: 21852544]/note:Contributes to necrotic cell death in macrophages [PMID: 26605666] chr1 CDS 4352274 4352576 . + . ID=CDS1;locus_tag=Rv3874;product=10 kDa culture filtrate antigen EsxB (LHP) (CFP10);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4352609 4352896 . + . ID=CDS1;locus_tag=Rv3875;product=6 kDa early secretory antigenic target EsxA (ESAT-6);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4353010 4355010 . + . ID=CDS1;locus_tag=Rv3876;product=ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4355007 4356542 . + . ID=CDS1;locus_tag=Rv3877;product=ESX conserved component EccD1. ESX-1 type VII secretion system protein. Probable transmembrane protein.;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4356693 4357535 . + . ID=CDS1;locus_tag=Rv3878;product=ESX-1 secretion-associated protein EspJ. Conserved alanine rich protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4357593 4359782 . - . ID=CDS1;locus_tag=Rv3879c;product=ESX-1 secretion-associated protein EspK. Alanine and proline rich protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4360199 4360546 . - . ID=CDS1;locus_tag=Rv3880c;product=ESX-1 secretion-associated protein EspL;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4360543 4361925 . - . ID=CDS1;locus_tag=Rv3881c;product=Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4362032 4363420 . - . ID=CDS1;locus_tag=Rv3882c;product=ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4363417 4364757 . - . ID=CDS1;locus_tag=Rv3883c;product=Membrane-anchored mycosin MycP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4364979 4366838 . - . ID=CDS1;locus_tag=Rv3884c;product=ESX conserved component EccA2. ESX-2 type VII secretion system protein. Probable CbxX/CfqX family protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4366908 4368521 . - . ID=CDS1;locus_tag=Rv3885c;product=ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4368518 4370170 . - . ID=CDS1;locus_tag=Rv3886c;product=Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4370155 4371684 . - . ID=CDS1;locus_tag=Rv3887c;product=ESX conserved component EccD2. ESX-2 type VII secretion system protein. Probable transmembrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4371681 4372706 . - . ID=CDS1;locus_tag=Rv3888c;product=Probable conserved membrane protein;note=FunctionalCategory: cell wall and cell processes;Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359]/note:Possible partitioning protein/note:Predicted structural similarity to PDB 3ez2B/inference:ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:3ez2B chr1 CDS 4372800 4373630 . - . ID=CDS1;locus_tag=Rv3889c;product=ESX-2 secretion-associated protein EspG2;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4373726 4374013 . - . ID=CDS1;locus_tag=Rv3890c;product=ESAT-6 like protein EsxC (ESAT-6 like protein 11);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4374049 4374372 . - . ID=CDS1;locus_tag=Rv3891c;product=Possible ESAT-6 like protein EsxD;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4374484 4375683 . - . ID=CDS1;locus_tag=Rv3892c;gene=PPE69;product=PPE family protein PPE69;Experiment=EXISTENCE:Liquid chromatography-mass spectrometry [PMID: 21085642]/note:FunctionalCategory: PE/PPE/note:Expressed in vivo in guinea pig lung at 90 but not 30 days post-infection [PMID: 21085642] chr1 CDS 4375762 4375995 . - . ID=CDS1;locus_tag=Rv3893c;gene=PE36;product=PE family protein PE36;note=FunctionalCategory: PE/PPE chr1 CDS 4376262 4380452 . - . ID=CDS1;locus_tag=Rv3894c;product=ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4380453 4381940 . - . ID=CDS1;locus_tag=Rv3895c;product=ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein.;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4381943 4382851 . - . ID=CDS1;locus_tag=Rv3896c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4383008 4383640 . - . ID=CDS1;locus_tag=Rv3897c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4383653 4383985 . - . ID=CDS1;locus_tag=Rv3898c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4384147 4385379 . - . ID=CDS1;locus_tag=Rv3899c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4385373 4386308 . - . ID=CDS1;locus_tag=Rv3900c;product=Conserved hypothetical alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4386365 4386814 . - . ID=CDS1;locus_tag=Rv3901c;product=Possible membrane protein;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4387365 4387895 . - . ID=CDS1;locus_tag=Rv3902c;gene=ift;product=Immunity factor for TNT (tuberculosis necrotizing toxin) (IFT);Experiment=DESCRIPTION:X-ray crystallography[PMID: 24699730],Experiment=DESCRIPTION:surface plasmon resonance, X-ray crystallography of TNT-IFT complex, in vitro pull down assay, enzyme activity assay [PMID: 26237511]/note:FunctionalCategory: conserved hypotheticals chr1 CDS 4387892 4390432 . - . ID=CDS1;locus_tag=Rv3903c;gene=cpnT;product=channel protein with necrosis-inducing toxin (CpnT) | (NAD+) glycohydrolase;Experiment=DESCRIPTION:flow cytometry, fluorescence microscopy, gene deletion mutant[PMID: 24753609],Experiment=DESCRIPTION:surface plasmon resonance, X-ray crystallography, thin-layer chromatography assays, flow cytometry[PMID: 26237511]/note:FunctionalCategory: conserved hypotheticals/note:C-terminal domain is secreted and is the toxin NAD+ glycohydrolase which induces necrosis (also named tuberculosis necrosis toxin or TNT) [PMID: 26237511]/note:N-terminal channel domain is used for uptake of nutrients [PMID: 24753609];EC_number=3.2.2.5 chr1 CDS 4390437 4390709 . - . ID=CDS1;locus_tag=Rv3904c;product=Putative ESAT-6 like protein EsxE (hypothetical alanine rich protein) (ESAT-6 like protein 12);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4390720 4391031 . - . ID=CDS1;locus_tag=Rv3905c;product=Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13);note=FunctionalCategory: cell wall and cell processes chr1 CDS 4391097 4391606 . - . ID=CDS1;locus_tag=Rv3906c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4391631 4393073 . - . ID=CDS1;locus_tag=Rv3907c;product=Probable poly(A) polymerase PcnA (polynucleotide adenylyltransferase) (NTP polymerase) (RNA adenylating enzyme) (poly(A) polymerase);note=FunctionalCategory: information pathways chr1 CDS 4393449 4394195 . + . ID=CDS1;locus_tag=Rv3908;product=Possible mutator protein MutT4;note=FunctionalCategory: information pathways chr1 CDS 4394192 4396600 . + . ID=CDS1;locus_tag=Rv3909;product=Conserved protein/putative host-directed protease effector;note=FunctionalCategory: conserved hypotheticals, Stuctural similarity to several secreted effector proteins, identified by similarity of predicted tertiary structure to PDB 4om9A,3szeA,1wxrA;Inference=ab initio prediction:I-TASSER:5.1/inference:alignment:TM-align:PDB:4om9A,3szeA,1wxrA chr1 CDS 4396597 4400151 . + . ID=CDS1;locus_tag=Rv3910;gene=mviN;product=Probable peptidoglycan biosynthetic protein;Experiment=DESCRIPTION:X-ray Crystallography, Phosphorylation site-mapping, purification and inducible expression and degradation in M.smegmatis, protein fragment complementation assay, mutagenesis, gas chromatography, laser-scanning microscopy [PMID: 22275220]/note:FunctionalCategory: cell wall and cell processes/note:forms homodimer before forming complex with FhaA if phosphorylated by protein kinase B (PknB) [PMID: 22275220]/note:A pseudokinase [PMID: 22275220],Experiment=COORDINATES:N-terminal peptide mass spectrometry [PMID: 26536359] chr1 CDS 4400186 4400854 . + . ID=CDS1;locus_tag=Rv3911;product=Possible alternative RNA polymerase sigma factor SigM;note=FunctionalCategory: information pathways chr1 CDS 4400870 4401634 . + . ID=CDS1;locus_tag=Rv3912;product=Hypothetical alanine rich protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4401728 4402735 . + . ID=CDS1;locus_tag=Rv3913;product=Probable thioredoxin reductase TrxB2 (TRXR) (TR);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4402732 4403082 . + . ID=CDS1;locus_tag=Rv3914;product=Thioredoxin TrxC (TRX) (MPT46);note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4403192 4404412 . + . ID=CDS1;locus_tag=Rv3915;product=Probable peptidoglycan hydrolase;note=FunctionalCategory: intermediary metabolism and respiration chr1 CDS 4404433 4405167 . - . ID=CDS1;locus_tag=Rv3916c;product=Conserved hypothetical protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4405457 4406491 . - . ID=CDS1;locus_tag=Rv3917c;product=Probable chromosome partitioning protein ParB;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4406488 4407531 . - . ID=CDS1;locus_tag=Rv3918c;product=Probable chromosome partitioning protein ParA;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4407528 4408202 . - . ID=CDS1;locus_tag=Rv3919c;product=Probable glucose-inhibited division protein B Gid;note=FunctionalCategory: cell wall and cell processes chr1 CDS 4408334 4408897 . - . ID=CDS1;locus_tag=Rv3920c;product=Conserved protein similar to jag protein;note=FunctionalCategory: conserved hypotheticals chr1 CDS 4408969 4410069 . - . ID=CDS1;locus_tag=Rv3921c;gene=yidC;product=putative translocase;Experiment=DESCRIPTION:binding assay through immunoblotting and co-immunoprecipitation, gene knockout, global microarray and proteomics [PMID: 27166092]/note:FunctionalCategory: cell wall and cell processes/note:expression is dependent on membrane potential [PMID: 27166092]/note:translocates respiratory proteins Rv0247, Rv0248, and QcrA [PMID: 27166092]/note:knockout strains have greatly reduced ATP synthase mRNA and protein levels, as well as ATP concentration [PMID: 27166092];EC_number=3.6.3.- chr1 CDS 4410053 4410415 . - . ID=CDS1;locus_tag=Rv3922c;product=Possible hemolysin;note=FunctionalCategory: virulence, detoxification, adaptation chr1 CDS 4410412 4410789 . - . ID=CDS1;locus_tag=Rv3923c;product=Ribonuclease P protein component RnpA (RNaseP protein) (RNase P protein) (protein C5);note=FunctionalCategory: information pathways chr1 CDS 4410786 4410929 . - . ID=CDS1;locus_tag=Rv3924c;product=50S ribosomal protein L34 RpmH;note=FunctionalCategory: information pathways chr1 miscRNA 2500445 2500751 . - . ID=miscRNA1;locus_tag=MTB000026;product=Ribonuclease P RNA;note=FunctionalCategory: stable RNAs chr1 miscRNA 3467967 3468334 . - . ID=miscRNA1;locus_tag=MTB000042;product=10Sa RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 293604 293705 . + . ID=ncRNA1;locus_tag=MTB000051;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 575033 575069 . + . ID=ncRNA1;locus_tag=MTB000060;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 704187 704247 . + . ID=ncRNA1;locus_tag=MTB000052;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 918264 918458 . + . ID=ncRNA1;locus_tag=MTB000053;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1175225 1175315 . + . ID=ncRNA1;locus_tag=MTB000061;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1220388 1220487 . - . ID=ncRNA1;locus_tag=MTB000074;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1283693 1283815 . + . ID=ncRNA1;locus_tag=MTB000072;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1340578 1340625 . + . ID=ncRNA1;locus_tag=MTB000075;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1365274 1365365 . + . ID=ncRNA1;locus_tag=MTB000062;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1413094 1413224 . - . ID=ncRNA1;locus_tag=MTB000063;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1471619 1471742 . + . ID=ncRNA1;locus_tag=MTB000064;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1535417 1535716 . - . ID=ncRNA1;locus_tag=MTB000065;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1547129 1547268 . + . ID=ncRNA1;locus_tag=MTB000076;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1914962 1915190 . - . ID=ncRNA1;locus_tag=MTB000054;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1952291 1952503 . - . ID=ncRNA1;locus_tag=MTB000055;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 1960667 1960783 . + . ID=ncRNA1;locus_tag=MTB000077;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 2139419 2139656 . + . ID=ncRNA1;locus_tag=MTB000056;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 2299745 2299886 . + . ID=ncRNA1;locus_tag=MTB000057;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 2437823 2437866 . - . ID=ncRNA1;locus_tag=MTB000066;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 2517032 2517134 . - . ID=ncRNA1;locus_tag=MTB000073;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 2692172 2692521 . + . ID=ncRNA1;locus_tag=MTB000067;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 2881252 2881320 . + . ID=ncRNA1;locus_tag=MTB000068;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 2882185 2882276 . + . ID=ncRNA1;locus_tag=MTB000069;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 4040879 4040938 . + . ID=ncRNA1;locus_tag=MTB000070;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 4093468 4093522 . + . ID=ncRNA1;locus_tag=MTB000071;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 4099386 4099478 . - . ID=ncRNA1;locus_tag=MTB000058;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 4100669 4100968 . + . ID=ncRNA1;locus_tag=MTB000078;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 4168154 4168281 . - . ID=ncRNA1;locus_tag=MTB000059;product=Possible 4.5S RNA in signal recognition particle (small cytoplasmic RNA) (SC-RNA);note=FunctionalCategory: stable RNAs chr1 ncRNA 4314798 4314891 . + . ID=ncRNA1;locus_tag=MTB000079;product=Fragment of putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 ncRNA 4317073 4317165 . + . ID=ncRNA1;locus_tag=MTB000080;product=Putative small regulatory RNA;note=FunctionalCategory: stable RNAs chr1 rRNA 1471846 1473382 . + . ID=rRNA1;locus_tag=MTB000019;product=Ribosomal RNA 16S;note=FunctionalCategory: stable RNAs chr1 rRNA 1473658 1476795 . + . ID=rRNA1;locus_tag=MTB000020;product=Ribosomal RNA 23S;note=FunctionalCategory: stable RNAs chr1 rRNA 1476899 1477013 . + . ID=rRNA1;locus_tag=MTB000021;product=Ribosomal RNA 5S;note=FunctionalCategory: stable RNAs chr1 tRNA 10887 10960 . + . ID=tRNA1;locus_tag=MTB000001;product=tRNA-Ile (GAT);note=FunctionalCategory: stable RNAs chr1 tRNA 11112 11184 . + . ID=tRNA1;locus_tag=MTB000002;product=tRNA-Ala (TGC);note=FunctionalCategory: stable RNAs chr1 tRNA 25644 25726 . + . ID=tRNA1;locus_tag=MTB000003;product=tRNA-Leu (CAG);note=FunctionalCategory: stable RNAs chr1 tRNA 386204 386274 . - . ID=tRNA1;locus_tag=MTB000004;product=tRNA-Gly (CCC);note=FunctionalCategory: stable RNAs chr1 tRNA 658109 658189 . + . ID=tRNA1;locus_tag=MTB000005;product=tRNA-Tyr (GTA);note=FunctionalCategory: stable RNAs chr1 tRNA 731494 731566 . + . ID=tRNA1;locus_tag=MTB000006;product=tRNA-Thr (GGT);note=FunctionalCategory: stable RNAs chr1 tRNA 731603 731676 . + . ID=tRNA1;locus_tag=MTB000007;product=tRNA-Met (CAT);note=FunctionalCategory: stable RNAs chr1 tRNA 733524 733596 . + . ID=tRNA1;locus_tag=MTB000008;product=tRNA-Trp (CCA);note=FunctionalCategory: stable RNAs chr1 tRNA 850642 850713 . - . ID=tRNA1;locus_tag=MTB000009;product=tRNA-Thr (TGT);note=FunctionalCategory: stable RNAs chr1 tRNA 923803 923875 . - . ID=tRNA1;locus_tag=MTB000010;product=tRNA-Lys (TTT);note=FunctionalCategory: stable RNAs chr1 tRNA 923999 924072 . + . ID=tRNA1;locus_tag=MTB000011;product=tRNA-Glu (TTC);note=FunctionalCategory: stable RNAs chr1 tRNA 924110 924183 . + . ID=tRNA1;locus_tag=MTB000012;product=tRNA-Asp (GTC);note=FunctionalCategory: stable RNAs chr1 tRNA 924213 924286 . + . ID=tRNA1;locus_tag=MTB000013;product=tRNA-Phe (GAA);note=FunctionalCategory: stable RNAs chr1 tRNA 1025321 1025393 . - . ID=tRNA1;locus_tag=MTB000014;product=tRNA-Arg (CCT);note=FunctionalCategory: stable RNAs chr1 tRNA 1113511 1113583 . + . ID=tRNA1;locus_tag=MTB000015;product=tRNA-Ala (CGC);note=FunctionalCategory: stable RNAs chr1 tRNA 1138076 1138147 . - . ID=tRNA1;locus_tag=MTB000016;product=tRNA-Gln (TTG);note=FunctionalCategory: stable RNAs chr1 tRNA 1177396 1177469 . + . ID=tRNA1;locus_tag=MTB000017;product=tRNA-Leu (TAA);note=FunctionalCategory: stable RNAs chr1 tRNA 1446193 1446265 . - . ID=tRNA1;locus_tag=MTB000018;product=tRNA-Arg (CCG);note=FunctionalCategory: stable RNAs chr1 tRNA 1512728 1512811 . + . ID=tRNA1;locus_tag=MTB000022;product=tRNA-Leu (TAG);note=FunctionalCategory: stable RNAs chr1 tRNA 1828015 1828088 . - . ID=tRNA1;locus_tag=MTB000023;product=tRNA-Leu (CAA);note=FunctionalCategory: stable RNAs chr1 tRNA 1946613 1946686 . + . ID=tRNA1;locus_tag=MTB000024;product=tRNA-Pro (GGG);note=FunctionalCategory: stable RNAs chr1 tRNA 2401987 2402072 . + . ID=tRNA1;locus_tag=MTB000025;product=tRNA-Leu (GAG);note=FunctionalCategory: stable RNAs chr1 tRNA 2510598 2510669 . - . ID=tRNA1;locus_tag=MTB000027;product=tRNA-Val (TAC);note=FunctionalCategory: stable RNAs chr1 tRNA 2581764 2581837 . - . ID=tRNA1;locus_tag=MTB000028;product=tRNA-Met (CAT);note=FunctionalCategory: stable RNAs chr1 tRNA 2619407 2619479 . - . ID=tRNA1;locus_tag=MTB000029;product=tRNA-Asn (GTT);note=FunctionalCategory: stable RNAs chr1 tRNA 2765331 2765404 . - . ID=tRNA1;locus_tag=MTB000030;product=tRNA-Pro (TGG);note=FunctionalCategory: stable RNAs chr1 tRNA 2765541 2765611 . + . ID=tRNA1;locus_tag=MTB000031;product=tRNA-Gly (TCC);note=FunctionalCategory: stable RNAs chr1 tRNA 2794176 2794249 . + . ID=tRNA1;locus_tag=MTB000032;product=tRNA-Arg (TCT);note=FunctionalCategory: stable RNAs chr1 tRNA 2827854 2827926 . + . ID=tRNA1;locus_tag=MTB000033;product=tRNA-His (GTG);note=FunctionalCategory: stable RNAs chr1 tRNA 2835494 2835566 . + . ID=tRNA1;locus_tag=MTB000034;product=tRNA-Lys (CTT);note=FunctionalCategory: stable RNAs chr1 tRNA 2969497 2969568 . - . ID=tRNA1;locus_tag=MTB000035;product=tRNA-Val (CAC);note=FunctionalCategory: stable RNAs chr1 tRNA 2969753 2969825 . + . ID=tRNA1;locus_tag=MTB000036;product=tRNA-Gly (GCC);note=FunctionalCategory: stable RNAs chr1 tRNA 2969855 2969925 . + . ID=tRNA1;locus_tag=MTB000037;product=tRNA-Cys (GCA);note=FunctionalCategory: stable RNAs chr1 tRNA 2969942 2970013 . + . ID=tRNA1;locus_tag=MTB000038;product=tRNA-Val (GAC);note=FunctionalCategory: stable RNAs chr1 tRNA 3348547 3348619 . - . ID=tRNA1;locus_tag=MTB000039;product=tRNA-Glu (CTC);note=FunctionalCategory: stable RNAs chr1 tRNA 3348659 3348730 . - . ID=tRNA1;locus_tag=MTB000040;product=tRNA-Gln (CTG);note=FunctionalCategory: stable RNAs chr1 tRNA 3431840 3431912 . - . ID=tRNA1;locus_tag=MTB000041;product=tRNA-Ala (GGC);note=FunctionalCategory: stable RNAs chr1 tRNA 3559370 3559443 . - . ID=tRNA1;locus_tag=MTB000043;product=tRNA-fMet (CAT);note=FunctionalCategory: stable RNAs chr1 tRNA 4081365 4081437 . - . ID=tRNA1;locus_tag=MTB000044;product=tRNA-Thr (CGT);note=FunctionalCategory: stable RNAs chr1 tRNA 4126541 4126614 . + . ID=tRNA1;locus_tag=MTB000045;product=tRNA-Pro (CGG);note=FunctionalCategory: stable RNAs chr1 tRNA 4168345 4168430 . + . ID=tRNA1;locus_tag=MTB000046;product=tRNA-Ser (GGA);note=FunctionalCategory: stable RNAs chr1 tRNA 4199131 4199217 . - . ID=tRNA1;locus_tag=MTB000047;product=tRNA-Ser (CGA);note=FunctionalCategory: stable RNAs chr1 tRNA 4216865 4216937 . - . ID=tRNA1;locus_tag=MTB000048;product=tRNA-Arg (ACG);note=FunctionalCategory: stable RNAs chr1 tRNA 4216968 4217056 . - . ID=tRNA1;locus_tag=MTB000049;product=tRNA-Ser (GCT);note=FunctionalCategory: stable RNAs chr1 tRNA 4222581 4222667 . - . ID=tRNA1;locus_tag=MTB000050;product=tRNA-Ser (TGA);note=FunctionalCategory: stable RNAs