Compound,SMILES, human sEH  IC50 (nM), murine sEH  IC50 (nM), rat sEH IC50 (nM)
9, CC1(C2)CC(C3=CC=CC=C34)CC2(N(C(N(C5=CC=C(C(F)(F)F)C=C5)[H])=S)[H])CC4C1, 138, -, -
11, CC1(C2)CC(C3=CC=CC=C34)CC2(N(C(OC5=CC=C(C)C=C5)=O)[H])CC4C1, >10000, -, -
13, C[C@@]1(C2)C[C@H](C3=CC=CC=C34)C[C@@]2(N([H])C(N([H])C5=C(F)C(F)=C(F)C=C5)=O)CC4C1, 1.0, -, -
14, C[C@@]1(O2)C[C@H](C3=CC=CC=C34)C[C@@]2(N([H])C(N([H])C5=C(F)C(F)=C(F)C=C5)=O)CC4C1, 20, -, -
16, CC1(C2)CC(C3=CC=CC=C34)CC2(N(C(N(C5CCN(C(C)=O)CC5)[H])=O)[H])CC4C1, 3.1, -, -
17, CC1(O2)CC(C3=CC=CC=C34)CC2(N(C(N(C5CCN(C(C)=O)CC5)[H])=O)[H])CC4C1, 941, -, -
18, [H]N(C(N(C1CCN(C(C)=O)CC1)[H])=O)C23CC4CC(O3)CC(C5=CC=CC=C54)C2, >10000, -, -
20, CC1(C2)CC(C3=CC=CC=C34)CC2(N(C(N([C@H]5CC[C@H](OC6=CC=C(C(O)=O)C=C6)CC5)[H])=O)[H])CC4C1, 0.9, 9.9, 0.4
21, CC1(O2)CC(C3=CC=CC=C34)CC2(N(C(N([C@H]5CC[C@H](OC6=CC=C(C(O)=O)C=C6)CC5)[H])=O)[H])CC4C1, 28, -, -
22, ClC1(C2)CC(C3=CC=CC=C34)CC2(N(C(N([C@H]5CC[C@H](OC6=CC=C(C(O)=O)C=C6)CC5)[H])=O)[H])CC4C1, 0.4, 0.4, 0.4
23, FC1(C2)CC(C3=CC=CC=C34)CC2(N(C(N([C@H]5CC[C@H](OC6=CC=C(C(O)=O)C=C6)CC5)[H])=O)[H])CC4C1, 0.5, 0.5, 0.4