COMPOUND BETA SE P P_ADJ MOA TARGET_GENES PHASE 3,3'-diindolylmethane -0.0678284758722786 0.021764558989836 0.00277289315474474 0.0431629594842342 CHK inhibitor, cytochrome P450 activator, indoleamine 2,3-dioxygenase inhibitor AR, HIF1A, IFNG, PI3 Phase 3 5-hydroxytryptophan -0.0541462310905538 0.0459151330997083 0.246245999821264 0.57819969772972 neurotransmitter SLC36A1, SLC36A2 Launched 6-aminochrysene -0.10275811537744 0.0449328944897968 0.0352956073623789 0.196488112554173 transferase inhibitor Phase 2 abc-294640 0.0251678810105319 0.0702796402737744 0.722411442778653 0.916925879326847 sphingosine kinase inhibitor SPHK2 Phase 2 abt-737 0.1198295392197 0.0259296146622366 1.16245165592619e-05 0.00239755654034777 BCL inhibitor BCL2, BCL2L1, BCL2L2 Phase 1/Phase 2 acadesine 0.0107964712000445 0.0566814243568532 0.849811993095962 0.947492917316845 AMPK activator Phase 3 acamprosate 0.0472744935601525 0.0302035201749184 0.15616796587866 0.44122798578731 glutamate receptor antagonist GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM5 Launched acarbose 0.0507689138864774 0.11109158489651 0.653456299427232 0.903017499208487 glucosidase inhibitor AMY2A, MGAM Launched acepromazine 0.0184741561609122 0.0927115986094185 0.84702703608266 0.947492917316845 dopamine receptor antagonist ADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A Launched acetyl-farnesyl-cysteine -0.00398450201113453 0.0163515904286358 0.808421964974116 0.94111784575798 methyltransferase inhibitor PPARG Launched acitretin 0.0162364165247174 0.0451530944455753 0.720585651670634 0.916925879326847 retinoid receptor agonist RARA, RARB, RARG, RBP1, RXRA, RXRB, RXRG, STAT3 Launched acy-1215 0.027033177624438 0.018149028180729 0.139294589693398 0.411892603932091 HDAC inhibitor HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 Phase 1/Phase 2 adapalene 0.10914949400037 0.124401452762028 0.386254030769645 0.722302117829717 retinoid receptor agonist RARA, RARB, RARG, RXRA, RXRB, RXRG Launched afatinib 0.0338532036609142 0.123661772836332 0.791207067102051 0.939202633610348 EGFR inhibitor EGFR, ERBB2, ERBB4 Launched alaproclate -0.132079873363003 0.0988157185344647 0.21810753924461 0.545268848111525 serotonin receptor antagonist SLC6A4 Phase 2 albendazole 0.117209903087509 0.0300564212676669 0.00454681579915868 0.0559869109597897 tubulin polymerization inhibitor TUBA1A, TUBB, TUBB4B Launched alectinib 0.0142782300030891 0.0262701427205298 0.587905514556349 0.864762447335015 ALK tyrosine kinase receptor inhibitor ALK, MET Launched alfadolone-acetate 0.0184184704234355 0.0450323313120876 0.69326620997714 0.910739845909459 benzodiazepine receptor agonist Phase 2 alfuzosin -0.0116881301284297 0.0854794645859109 0.894617856762066 0.961015275818626 adrenergic receptor antagonist ADRA1A, ADRA1B, ADRA1D, SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A Launched alpelisib 0.016167472166722 0.0383498163109166 0.676797613919094 0.910739845909459 PI3K inhibitor PIK3CA, PIK3CB, PIK3CD, PIK3CG Launched alpha-linolenic-acid 0.0358972019052334 0.0292440431423969 0.236359911682168 0.563574933924244 omega 3 fatty acid stimulant ELOVL4, FADS1, FADS2, FFAR1, FFAR4, PTGS2, SLC8A1, TRPV1 Phase 3 alprenolol 0.00447547437427587 0.0805083917742206 0.956316422761885 0.985508830066777 adrenergic receptor antagonist ADRB1, ADRB2 Launched alprostadil 0.137396938799806 0.0609413151771986 0.0541788782849789 0.247224671988414 prostanoid receptor agonist CATSPER1, CATSPER2, CATSPER3, CATSPER4, PTGDR, PTGER1, PTGER2, PTGER4, PTGIR Launched altanserin -0.263910188523158 0.162968538397369 0.144022504823245 0.421342434323323 serotonin receptor antagonist HTR2A Phase 2 altrenogest 0.0019329355745074 0.0727042402665766 0.979440944738198 0.989492436074094 progestogen hormone PGR Launched altretamine -0.0440982503452516 0.0506525802833896 0.39609909356877 0.73105537403632 DNA synthesis inhibitor Launched alverine 0.103540629807595 0.111112250916988 0.378675090969322 0.714033351072222 muscle relaxant HTR1A Launched alvespimycin 0.0324539394128216 0.0659696225930626 0.629044869148864 0.896431567177881 HSP inhibitor HSP90AA1 Phase 2 alvocidib 0.0544487504937671 0.0307106835374413 0.0811476499817818 0.309574840008147 CDK inhibitor CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, EGFR, PYGM Phase 2 amantadine -0.12154835190907 0.0924226112772845 0.224906911713628 0.550588136984401 glutamate receptor antagonist DRD2, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A Launched ambroxol -0.0469518080398447 0.0705454580796491 0.524417422940679 0.814772832252467 sodium channel blocker CYP3A4 Launched amcinonide 0.080677287623638 0.101106666037648 0.447939873093738 0.766702064942601 glucocorticoid receptor agonist NR3C1 Launched amiloride 0.0881080481648552 0.0301449976914979 0.0192084868472891 0.136612083181151 sodium channel blocker AOC1, ASIC1, ASIC2, ASIC3, PKD2, PKD2L1, PLAU, SCNN1A, SCNN1B, SCNN1D, SCNN1G, SLC9A1, TRPC7, TRPV2 Launched aminoglutethimide -0.140784645655091 0.0557387029407414 0.0354869439643295 0.196488112554173 glucocorticoid receptor antagonist CYP11A1, CYP19A1 Launched aminopentamide -0.0441875692100547 0.0306556043376384 0.187439577538459 0.497077978862734 acetylcholine receptor antagonist CHRM1 Launched amiodarone 0.198147323205931 0.0447971591885432 6.30406984522123e-05 0.00618738915867171 potassium channel blocker ADRB1, CACNA1H, CACNA2D2, KCNA7, KCNH2 Launched amitriptyline -0.00655275444178281 0.120695155698022 0.958034038440673 0.985508830066777 norepinephrine inhibitor, norepinephrine reuptake inhibitor, serotonin receptor antagonist, serotoninƒ__norepinephrine reuptake inhibitor (SNRI) ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HRH1, HRH2, HRH4, HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, HTR6, HTR7, KCNA1, KCND2, KCND3, KCNQ2, KCNQ3, NTRK1, NTRK2, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC6A2, SLC6A4 Launched amlodipine 0.195765486679142 0.0681109180600613 0.0206945024946849 0.145922774000983 calcium channel blocker CACNA1C, CACNA1D, CACNA1F, CACNA1S, CACNA2D1 Launched amodiaquine 0.0597733626839863 0.0437545424484798 0.189706334215802 0.500024682837178 histamine receptor agonist HNMT Launched amonafide 0.188980237420066 0.0825720001156831 0.0513712182589927 0.240802585589028 topoisomerase inhibitor TOP2A, TOP2B Phase 3 amoxapine -0.0322845101427803 0.100384429819388 0.755991328946662 0.927861770638128 norepinephrine reputake inhibitor ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, HRH1, HRH4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, HTR6, HTR7, SLC6A2, SLC6A3, SLC6A4 Launched amperozide 0.0210765642910628 0.0723780104416392 0.778304769320962 0.932391101354502 dopamine receptor antagonist FAAH, HTR2A Launched amsacrine 0.162353218406904 0.0884328051381592 0.103696210444113 0.357947169943068 topoisomerase inhibitor KCNH2, TOP2A Launched amuvatinib -0.0217788605343523 0.0341012684660524 0.524413696361629 0.814772832252467 FLT3 inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RAD51 inhibitor, RET tyrosine kinase inhibitor KIT, MET Phase 2 anagrelide 0.189323827675459 0.068628246631227 0.0247248780771538 0.160614365461826 phosphodiesterase inhibitor PDE3A Launched anandamide -0.0461659935624973 0.0111480056873755 0.000106294101679502 0.00618738915867171 cannabinoid receptor agonist CACNA1G, CACNA1H, CACNA1I, CNR1, CNR2, GLRA1, GPR18, GPR55, KCNA2, KCNK3, KCNK9, TRPM8, TRPV1 Phase 2 andarine -0.00994972266883058 0.0465152467294847 0.833167680233215 0.947492917316845 androgen receptor modulator AR Phase 1 aniracetam 0.0359337330218785 0.0261952538825057 0.177091142556779 0.475896392864308 glutamate receptor agonist DRD2, GRIA1, GRIA2, GRIA3, GRIA4, HTR2A Launched apafant 0.00911993302562831 0.0510686555616679 0.860377000430234 0.951489310127269 platelet activating factor receptor antagonist PTAFR Phase 3 aprepitant 0.00407947935956061 0.0212287937302136 0.849887977413425 0.947492917316845 tachykinin antagonist TACR1 Launched as-703026 0.0203408243083045 0.128591897137343 0.876177781918188 0.954883315828937 MEK inhibitor MAP2K1, MAP2K2 Phase 2 ast-1306 0.0189059999550611 0.0253825610503521 0.458000048677622 0.773798829426204 EGFR inhibitor EGFR, ERBB2 Phase 1 at-7519 0.0460941388361484 0.0964811134525285 0.638911226061326 0.896431567177881 CDK inhibitor CDK1, CDK2, CDK4, CDK5, CDK6, CDK9 Phase 2 atorvastatin 0.0098463187968468 0.0256677246453502 0.703590169842819 0.915555031735529 HMGCR inhibitor AHR, DPP4, HMGCR Launched axitinib 0.0157070321700792 0.066440722226003 0.81594204460872 0.946731910237955 PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor CSF1, FLT1, FLT4, KDR, PLK4 Launched azacitidine 0.04942567341347 0.0305929234307521 0.109127495390127 0.366638480412332 DNA methyltransferase inhibitor DNMT1, DNMT3A Launched azaperone -0.112972805296028 0.153784991350845 0.483548073425608 0.791522144000251 dopamine receptor antagonist DRD2, DRD3 Launched azasetron 0.139087398623438 0.097950541973805 0.193388834247475 0.506494565886244 serotonin receptor antagonist HTR3A, HTR3B Launched barasertib-hqpa -0.00628759628603069 0.043999165420938 0.887186618553052 0.957572900671529 Aurora kinase inhibitor AURKB Phase 2/Phase 3 be-2254 0.141578057252409 0.0299125210909733 0.00147707421009967 0.0290139576983864 adrenergic receptor antagonist ADRA1A Phase 2 beclomethasone-dipropionate -0.0282097384648427 0.0407911099914763 0.498546655387836 0.800894314794982 glucocorticoid receptor agonist GPR97, NR3C1 Launched belinostat 0.0441370661183508 0.0464708278294926 0.344056742464905 0.672520521029605 HDAC inhibitor HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 Launched bemegride 0.0477691318639862 0.0470936934059867 0.340111379989534 0.669670378261016 chemoreceptor agonist GABRA1 Launched bemesetron 0.0888285315591813 0.0406757711991102 0.0432789109214454 0.223156884438703 serotonin receptor antagonist HTR3A, HTR3B Phase 3 benazepril -0.0720632518993323 0.0890628307581981 0.441839087269585 0.764187100623496 angiotensin converting enzyme inhibitor ACE Launched bendroflumethiazide 0.0354094629298402 0.0324806143890598 0.290849375896631 0.623248662635638 sodium/potassium/chloride transporter inhibitor SLC12A1, SLC12A3 Launched benperidol -0.0942581007405233 0.0528308162375869 0.0922578349174531 0.336616252718862 dopamine receptor antagonist DRD2 Launched benzamil -0.0567829588567427 0.0301952126679354 0.0968267772472518 0.346504986762374 sodium channel blocker ASIC1, PKD2L1, SCNN1A, SCNN1B, SCNN1D, SCNN1G, SLC8A1 Phase 2 benzonatate -0.080932073411921 0.0570401976773659 0.174014042517918 0.47069372156486 local anesthetic SCN5A Launched benzthiazide -0.0393142085646822 0.0376704698047445 0.32716217325162 0.653530000444668 carbonic anhydrase inhibitor CA2 Launched benzydamine -0.0327443947149672 0.0681057383162445 0.643540671407922 0.8998661930704 prostanoid receptor antagonist Launched benzylpenicillin -0.0281543230473343 0.0302406219958928 0.379086797296525 0.714033351072222 penicillin binding protein inhibitor Launched bepridil 0.0455617424897739 0.0212843378417111 0.0470936813560875 0.23087924768806 calcium channel blocker KCNQ4 Launched betahistine 0.00368518921977731 0.143491883891367 0.980139882328078 0.989492436074094 histamine receptor agonist, histamine receptor antagonist HRH1, HRH3 Launched betamethasone -0.0951328069914898 0.0346684481963085 0.0138387871210898 0.111931366420579 glucocorticoid receptor agonist NR3C1 Launched betamethasone-acetate -0.0388060146766022 0.0510663960280149 0.469106409618623 0.783306009865478 glucocorticoid receptor agonist NR3C1 Launched betaxolol -0.061082023196744 0.0462165744197098 0.222828107330268 0.549574790413354 adrenergic receptor antagonist ADRB1, ADRB2 Launched betulinic-acid 0.0155279621512121 0.0434107323330753 0.724971253364772 0.917333257708492 apoptosis stimulant, NFkB pathway inhibitor GPBAR1 Phase 1/Phase 2 bezafibrate -0.0726041918776667 0.0225207987351108 0.00238503344018349 0.0382022678483128 PPAR receptor agonist PPARA, PPARD, PPARG Launched bi-2536 0.0571510540951211 0.0537188216205849 0.289772439724576 0.623248662635638 PLK inhibitor BRD4, PLK1, PLK2, PLK3 Phase 2 bibx-1382 0.0283923763081173 0.0772326872724124 0.722691296714217 0.916925879326847 EGFR inhibitor EGFR, ERBB2 Phase 1 bicalutamide -0.0241630692770817 0.101814139901533 0.818369186984168 0.946731910237955 androgen receptor antagonist AR Launched bifemelane -0.0138091715883006 0.0506576736505515 0.788445888914905 0.937273571116422 acetylcholine release enhancer MAOA, MAOB Launched biotin -0.0193416686532066 0.138651575580961 0.892504311872704 0.959994859576246 vitamin B ACACA, ACACB, HLCS, MCCC1, MCCC2, PC, PCCA, PCCB, SLC5A6 Launched biperiden 0.0660788099026814 0.0797874472111611 0.419041052488752 0.751541018050479 acetylcholine receptor antagonist CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 Launched bisacodyl -0.0614859690630712 0.0816249057992258 0.472868223805679 0.784564160418255 laxative Launched bisoprolol 0.0908047661171196 0.0830386312854639 0.305994198076793 0.637563106741104 adrenergic receptor antagonist ADRB1 Launched bms-777607 -0.0558953846746411 0.0257306017851445 0.032037827748999 0.18951184274107 AXL kinase inhibitor, c-Met inhibitor, FLT3 inhibitor, hepatocyte growth factor receptor inhibitor, macrophage migration inhibiting factor inhibitor, tyrosine kinase inhibitor AXL, MERTK, MET, MST1R, TYRO3 Phase 1/Phase 2 bms-906024 -0.0977960153134127 0.0491321518936974 0.057148820451245 0.256237917784115 gamma secretase inhibitor Phase 1 bmy-14802 0.120801808132455 0.0931949300350632 0.231038143550571 0.554088571015178 sigma receptor antagonist HTR1A Phase 2 bosutinib 0.0499621869189543 0.0357682492272421 0.164500572686343 0.453728329461556 Abl kinase inhibitor, Bcr-Abl kinase inhibitor, SRC inhibitor ABL1, BCR, CAMK1D, CAMK2G, CDK2, FRK, FYN, HCK, LYN, MAP2K1, MAP2K2, MAP3K2, MAP4K5, SRC, STK10, STK24, STK4, TNK2, TXK Launched bp-897 0.0124686905231611 0.0371069575943247 0.745498937548745 0.922253610491613 dopamine receptor agonist ADRA1A, ADRA1D, ADRA2A, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2B Phase 2 brimonidine -0.0179102780010716 0.0452298531102867 0.697042877696228 0.910909654393513 adrenergic receptor agonist ADRA2A, ADRA2B, ADRA2C Launched brinzolamide 0.0720959351048644 0.068389088619721 0.322585491679023 0.652286839792142 carbonic anhydrase inhibitor CA1, CA12, CA14, CA2, CA4, CA5A, CA7 Launched brivanib 0.0279831363883425 0.0520531347132013 0.597829187641634 0.872936424432474 FGFR inhibitor, VEGFR inhibitor CYP3A4, FGFR1, FLT1, KCNH2, KDR Phase 3 brl-37344 0.14822214400574 0.0758303128821007 0.0863685982376931 0.323882243391349 adrenergic receptor agonist ADRB1, ADRB2, ADRB3 Phase 2 bromhexine 0.0862338530384652 0.0293450493458081 0.00917879418969869 0.0870402897299014 mucolytic agent Launched bromocriptine 0.0254292708337422 0.0173971748438726 0.15580839515764 0.44122798578731 dopamine receptor agonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR6, HTR7 Launched brompheniramine -0.0213158459844379 0.161133680754988 0.898024204150331 0.963419984946714 histamine receptor antagonist HRH1 Launched bucladesine -0.0508207793576627 0.0847089806726413 0.565144577729964 0.846178360484973 adenosine receptor agonist, cAMP stimulant PRKACA Launched budesonide 0.0130526277841149 0.0495169839946798 0.795257501665606 0.940886055567534 glucocorticoid receptor agonist NR3C1 Launched bumetanide 0.0208824936261621 0.102760234361557 0.844040046907937 0.947492917316845 solute carrier family member inhibitor CFTR, GPR35, SLC12A1, SLC12A2, SLC12A4, SLC12A5 Launched buphenine 0.121285955341759 0.0300187173694303 0.0037339585881771 0.0511333471144013 adrenergic receptor agonist ADRB2 Launched bupropion 0.00272760331798896 0.127804203952445 0.983495512219099 0.989492436074094 dopamine reuptake inhibitor SLC6A2, SLC6A3 Launched buspirone -0.0565083315290726 0.0212009634367982 0.0163109869950409 0.121367312788305 serotonin receptor agonist DRD2, HTR1A Launched buthionine-sulfoximine 0.0280552613269778 0.0824431383383945 0.737800648877606 0.920830898520516 glutathione transferase inhibitor GCLM Phase 1 butoconazole 0.00882936994293747 0.112538150832938 0.939391698371891 0.984184670138276 bacterial cell wall synthesis inhibitor Launched cabergoline -0.0114128569104123 0.0927736415307469 0.903038615509779 0.966286456284783 dopamine receptor agonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7 Launched cabozantinib -0.0362559989491641 0.0262139091819854 0.169518867550354 0.460042979371849 RET tyrosine kinase inhibitor, VEGFR inhibitor KDR, MET, RET Launched caffeine -0.0354584325332773 0.0892673471275959 0.693128427777759 0.910739845909459 adenosine receptor antagonist, phosphodiesterase inhibitor ADORA1, ADORA2A, ADORA2B, ADORA3, ATM, ITPR1, ITPR2, ITPR3, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6A, PDE6B, PDE6C, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PIK3CA, PIK3CB, PIK3CD, PRKDC, RYR1, RYR2, RYR3 Launched calcifediol 0.0515225360531092 0.0121457683187389 8.92879938902846e-05 0.00618738915867171 vitamin D receptor agonist VDR Launched calcitriol 0.0324347095379507 0.0328414826303522 0.327829139668053 0.653530000444668 vitamin D receptor agonist VDR Launched camptothecin 0.127897761211676 0.0588799389694934 0.0616089521525681 0.271333197082795 topoisomerase inhibitor TOP1 Phase 3 canertinib 0.0423531973880057 0.0213491601564736 0.0636627531474475 0.274470254057028 EGFR inhibitor AKT1, EGFR, ERBB2, ERBB4 Phase 3 capecitabine 0.00117206288563114 0.0986986922380125 0.990663464476475 0.99186572596249 DNA synthesis inhibitor, thymidylate synthase inhibitor TYMS Launched capsaicin 0.049544810753345 0.0444471661860039 0.272579234025805 0.606145454842914 TRPV agonist CFTR, TRPV1 Launched carbamazepine 0.0251737152503589 0.0131363016343704 0.0618310800625036 0.271333197082795 carboxamide antiepileptic SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A Launched carbenoxolone 0.054691941413134 0.120213022935468 0.654895420829089 0.903397140476511 11-beta hydroxysteroid dehydrogenase inhibitor GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, GJE1, HSD11B1, PANX1, PANX2, PANX3 Launched carbetocin -0.0323191823078438 0.051071348540136 0.535268899299643 0.822340487750848 oxytocin receptor agonist OXTR Launched carbidopa -0.0387753533636701 0.0166945521525012 0.0261373223055611 0.162864097299983 aromatic L-amino acid decarboxylase inhibitor DDC Launched carbinoxamine 0.0415590314977926 0.0738387497734589 0.588968277594148 0.864762447335015 histamine receptor antagonist HRH1 Launched carmoxirole 0.0657389711794353 0.0432471599872098 0.146872205031776 0.426653412504279 dopamine receptor agonist DRD2 Phase 2 carprofen -0.0417455658044983 0.0843318657514464 0.633897248932499 0.896431567177881 cyclooxygenase inhibitor PTGS2 Launched carteolol 0.125941592450483 0.0299370774562669 0.00296850097271333 0.0453520981942314 adrenergic receptor antagonist ADRB1, ADRB2, ADRB3 Launched carvedilol 0.144483935248062 0.03664452821596 0.00427872988708721 0.053750821406193 adrenergic receptor antagonist ADRB1, ADRB2, ADRB3 Launched cc-401 0.0531804641685208 0.0233012514508898 0.024047080486779 0.157451122234862 JNK inhibitor MAPK8 Phase 1 cediranib 0.125002447704993 0.063713462561527 0.06635386457202 0.279058862265764 KIT inhibitor, VEGFR inhibitor CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB Phase 3 cefixime 0.0166715316090946 0.0638025247617062 0.797001290731428 0.940886055567534 bacterial cell wall synthesis inhibitor Launched ceforanide -0.0614129404377517 0.0802873572468696 0.454810895714633 0.773600034208035 penicillin binding protein inhibitor Launched cefotiam 0.179986952292108 0.0657021067123952 0.025471291009074 0.161919560707621 bacterial cell wall synthesis inhibitor Launched celecoxib 0.0282264027107429 0.0541591413471637 0.604858074428455 0.875452476146448 cyclooxygenase inhibitor CA12, PDPK1, PTGS2 Launched cerulenin 0.0984533328161668 0.0453111472836146 0.036649291813392 0.20047046031373 fatty acid synthase inhibitor FASN Launched cetirizine 0.0812074237826158 0.117057601006365 0.507485320264988 0.803897247100331 histamine receptor antagonist HRH1 Launched cgp-12177 0.163951316037353 0.0813658189823252 0.078667317721917 0.308178907081086 adrenergic receptor agonist ADRB1, ADRB2, ADRB3 Phase 1 cgs-20625 -0.0558481148779003 0.0465506086215006 0.246698537698014 0.57819969772972 benzodiazepine receptor agonist, GABA benzodiazepine site receptor partial agonist GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 Phase 1 chenodeoxycholic-acid -0.0302333542481322 0.0635282551264547 0.636098615833573 0.896431567177881 11-beta hydroxysteroid dehydrogenase inhibitor, FXR agonist HSD11B1, NR1H4 Launched chlorambucil 0.0843762998102149 0.100080974968677 0.42367216275666 0.75299343742725 DNA inhibitor Launched chlorhexidine 0.0434474537993224 0.0813874291884922 0.600367231085789 0.873550203960804 membrane integrity inhibitor Launched chlormadinone-acetate 0.148168029046415 0.0466964532317162 0.0131350934331522 0.110178207591459 5 alpha reductase inhibitor PGR Launched chloroquine -0.0614444615140486 0.0370655369358721 0.104486984968282 0.35890911216815 antimalarial agent MRGPRX1 Launched chloroxine -0.0230195985948559 0.0501036228517035 0.651739038010199 0.902155547581232 opioid receptor antagonist OPRK1 Launched chlorphenamine -0.0610745732632168 0.0550833499976178 0.282970936713482 0.620880379756975 histamine receptor antagonist Launched chlorpromazine 0.0883744774809237 0.0315662219253267 0.00574179017754946 0.0662330063426812 dopamine receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CALM1, CHRM1, CHRM3, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH4, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, HTR7, KCNH2, ORM1, ORM2, SMPD1, TRPC5 Launched chlorprothixene 0.0787870411318597 0.080087140766094 0.339025331629047 0.669128944004698 dopamine receptor antagonist CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, HRH1, HTR2A, HTR2B, HTR2C Launched chlorthalidone -0.00641205040681622 0.0302682077448258 0.837528448030081 0.947492917316845 carbonic anhydrase inhibitor CA1, CA12, CA14, CA2, CA4, CA7, SLC12A1 Launched cholic-acid -0.00526562908057561 0.0737917596635097 0.943381463531466 0.984184670138276 bile acid ADH1C, CES1, COX4I1, COX5A, COX5B, COX6A2, COX6B1, COX6C, COX7A1, COX7B, COX7C, COX8A, ESRRG, FABP6, FECH, GPBAR1, MT-CO1, MT-CO2, MT-CO3, PLA2G1B Launched ci-966 -0.14683876718566 0.0898753984816471 0.120681541347119 0.379240814410728 GAT inhibitor SLC6A1 Phase 1 ciglitazone -0.0405545715574747 0.0270816200998162 0.141404738411425 0.41555803335169 PPAR receptor agonist PPARG Phase 2 cilastatin 0.0657574896688259 0.0399751058512426 0.118340409289644 0.375715717438561 dehydropeptidase inhibitor DPEP1 Launched cilnidipine -0.0152687573171435 0.142350475729094 0.917222522510892 0.979483776428112 calcium channel blocker CACNA1B Launched cilomilast -0.102429160888149 0.0253148006174671 0.000838887139993584 0.0223252222740228 phosphodiesterase inhibitor PDE4A, PDE4B, PDE4D Phase 3 cilostazol 0.10297866818183 0.0792783176157452 0.230146239792916 0.554088571015178 phosphodiesterase inhibitor PDE3A, PDE3B Launched cimetidine 0.0986079703237014 0.0614906495814794 0.127212543853169 0.391605778652479 histamine receptor antagonist HRH2, SLC29A4, SLC47A1, SLC47A2 Launched cinacalcet -0.0626262767931656 0.0211229099561304 0.00868085131939828 0.0842553216294539 calcium channel activator CASR Launched cinalukast 0.141997225559512 0.0582551051574548 0.0407225587849628 0.214366686343455 leukotriene receptor antagonist CYSLTR1 Phase 2 ciprofibrate 0.123487897389946 0.0697250925012937 0.114499526945016 0.37210990544334 PPAR receptor agonist PPARA Launched cl-218872 0.0326031998835571 0.0414006320814927 0.441828523559058 0.764187100623496 benzodiazepine receptor agonist GABRA1, GABRA2, GABRA3, GABRA5, GABRB2, GABRG2 Phase 1 clemastine -0.0425520562096059 0.0573799400283053 0.479541108351903 0.788090466912988 histamine receptor antagonist HRH1 Launched clocortolone-pivalate 0.00916594925051845 0.0431601368533463 0.834343371861166 0.947492917316845 steroid NR3C1, PLA2G1B Launched clofarabine 0.0565353752326203 0.0690000706039382 0.423923987683975 0.75299343742725 ribonucleotide reductase inhibitor POLA1, POLD1, POLE, RRM1, RRM2, RRM2B Launched clofibrate -0.0500881103838255 0.0981564800486954 0.623627539443735 0.894096763365284 PPAR receptor agonist LPL, PPARA Launched clofibric-acid -0.0124999690478452 0.0657208016583816 0.84988055886847 0.947492917316845 PPAR receptor agonist PPARA Launched clomethiazole 0.111261262854627 0.0959181922908496 0.279510131718856 0.615860300715999 GABA receptor antagonist, GABA receptor modulator GABRA1 Launched clomifene 0.0313309122061441 0.0754434000847877 0.683123787192906 0.910739845909459 estrogen receptor antagonist ESR1 Launched clomipramine -0.0852831922413354 0.104638506592696 0.438645003937276 0.761857112101585 serotonin transporter (SERT) inhibitor GSTP1, HTR2A, HTR2B, HTR2C, SLC6A2, SLC6A3, SLC6A4 Launched clonidine -0.0504096397604657 0.0741119046774429 0.499952208629595 0.800894314794982 adrenergic receptor agonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C Launched clopidogrel -0.0301011259444751 0.0320256187078055 0.353706826805957 0.684995615293227 purinergic receptor antagonist P2RY12 Launched clorgiline 0.029531051513308 0.0451786089029695 0.517608259760417 0.810624673563108 monoamine oxidase inhibitor MAOA Phase 2 clozapine 0.0492291408470409 0.031117663704703 0.120804776453816 0.379240814410728 dopamine receptor antagonist, serotonin receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CALY, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR5A, HTR6, HTR7 Launched co-102862 0.133418711091606 0.10903423476441 0.255902539740975 0.58807686709277 sodium channel blocker SCN4A, SCN9A Phase 1 colforsin -0.11575312223058 0.0606235892958 0.0926204719602202 0.336616252718862 adenylyl cyclase activator ADCY2, ADCY5 Phase 2 cortisone 0.0345882820831947 0.0477427430515433 0.473591456834292 0.784564160418255 glucocorticoid receptor agonist NR3C1 Launched cortisone-acetate -0.142739480360309 0.0808488671038584 0.115473563672533 0.372140570603971 glucocorticoid receptor agonist NR3C1 Launched coumarin 0.131622798229222 0.118677735440865 0.299621105108829 0.633813876191754 vitamin K antagonist CA1, CA12, CA14, CA2, CA4, CA6, CA9, CYP2A6 Launched cp-724714 0.00835895857888488 0.0150711471955745 0.582672789665652 0.863025227063129 EGFR inhibitor, protein tyrosine kinase inhibitor ERBB2 Phase 2 crizotinib 0.0794067650107355 0.0628983371189496 0.223826823731984 0.549574790413354 ALK tyrosine kinase receptor inhibitor ALK, MET Launched cromakalim -0.021034483426197 0.0211490897461957 0.33388685695857 0.660567522759761 KCNJ8 Phase 2 crotamiton -0.0230027302791835 0.0816409957171732 0.785282728878533 0.935172243505201 antipruritic Launched curcumin 0.0475612871156296 0.0238922007682218 0.0543715893167149 0.247224671988414 cyclooxygenase inhibitor, histone acetyltransferase inhibitor, lipoxygenase inhibitor, NFkB pathway inhibitor APP, CA1, CA12, CA14, CA2, CA4, CA6, CA9, CHRM3, CYP3A4, DNMT3B, EP300, MMP13, MMP9, NOS2, PTGS1, PTGS2, XDH Launched cx-5461 0.0132181411679061 0.046759389888534 0.77796504189307 0.932391101354502 RNA polymerase inhibitor Phase 1 cyanopindolol 0.0626273937266289 0.0238958418682776 0.0128897414122379 0.110178207591459 adrenergic receptor antagonist ADRB1, HTR1A, HTR1D Phase 2 cyclopenthiazide -0.0732167206762001 0.146373746466867 0.630398770976545 0.896431567177881 thiazide diuretic Launched cyclopentolate -0.0990828401141493 0.159266282022551 0.551177089044103 0.840023015155564 acetylcholine receptor antagonist Launched cyclosporin-a 0.114763586479171 0.0415597351442701 0.00836378893404612 0.0827699938335376 calcineurin inhibitor ABCB11, CAMLG, FPR1, PPIA, PPIF, PPP3CA, PPP3R2, SLC10A1, SLCO1B1, SLCO1B3 Launched dabrafenib -0.0422811343602932 0.0406860148262235 0.301051739687316 0.634258004966583 RAF inhibitor BRAF, LIMK1, NEK11, RAF1, SIK1 Launched dacinostat -0.0192701892856707 0.0248768465384721 0.443764005031059 0.76591067813938 HDAC inhibitor HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 Phase 1 dacomitinib -0.0340266708311083 0.0458745478320243 0.460022961542878 0.774528455658927 EGFR inhibitor EGFR, ERBB2, ERBB4 Launched danazol 0.0401341299081274 0.0845318765166564 0.637892334568746 0.896431567177881 estrogen receptor antagonist, progesterone receptor agonist AR, CCL2, ESR1, GNRHR, GNRHR2, PGR Launched danoprevir 0.0304666350515435 0.0208882198614701 0.162916202891919 0.452545008033108 HCV inhibitor Phase 3 dantrolene 0.171435415881987 0.0565943961435461 0.0163294202660629 0.121367312788305 calcium channel blocker RYR1, RYR3 Launched danusertib -0.0505534444678845 0.0403397910630468 0.227099410542202 0.552675556629253 Aurora kinase inhibitor, growth factor receptor inhibitor AURKA, AURKB, AURKC, FGFR1, NTRK1, RET, SLK Phase 2 dasatinib 0.0668755805522673 0.0321293688904804 0.038138608017767 0.206028203991647 Bcr-Abl kinase inhibitor, ephrin inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, SRC inhibitor, tyrosine kinase inhibitor ABL1, ABL2, BLK, EPHA2, FGR, FRK, FYN, HCK, KIT, LCK, LYN, PDGFRB, SRC, SRMS, STAT5B, YES1 Launched daunorubicin 0.113592734223053 0.0628337860214348 0.0883595808283493 0.326890825934476 RNA synthesis inhibitor, topoisomerase inhibitor TOP2A, TOP2B Launched decitabine -0.0524044267097446 0.032730469706253 0.110959338418908 0.369118766917738 DNA methyltransferase inhibitor DNMT1, DNMT3A Launched deforolimus 0.0947175972398995 0.065115115214094 0.163990599620365 0.453728329461556 mTOR inhibitor MTOR Phase 3 deoxycholic-acid 0.0513259075364008 0.0280565961957369 0.0706926724380449 0.288720073076173 biliverdin reductase A activator, G protein-coupled receptor agonist FPR1, GPBAR1 Launched deracoxib -0.0750325716993595 0.152958876320409 0.636922138869897 0.896431567177881 cyclooxygenase inhibitor PTGS2 Launched desipramine 0.104998379502095 0.0687998577812588 0.165488257590442 0.453728329461556 tricyclic antidepressant ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR1A, HTR2A, HTR2C, SLC6A2, SLC6A4, SMPD1 Launched desmethylclozapine -0.0147556918585548 0.0591375657202119 0.805952595468375 0.94111784575798 acetylcholine receptor agonist HTR2C Phase 2 desoximetasone -0.092929140526356 0.151458187466038 0.556543198932293 0.842466183255701 glucocorticoid receptor agonist NR3C1, PLA2G1B Launched desoxypeganine -0.060990229084603 0.0903897836841575 0.518856889828004 0.810624673563108 acetylcholinesterase inhibitor, monoamine oxidase inhibitor ACHE Phase 1 dexamethasone 0.0339439463449706 0.0657100344972093 0.607060462374398 0.877101368579472 glucocorticoid receptor agonist ANXA1, NOS2, NR0B1, NR3C1, NR3C2 Launched dexamethasone-acetate 0.0549210404568176 0.162360533340007 0.743868980587205 0.922253610491613 glucocorticoid receptor agonist Launched dexrazoxane 0.0171687489698347 0.0900310306713755 0.851020911190039 0.947492917316845 chelating agent, topoisomerase inhibitor TOP2A, TOP2B Launched dextromethorphan -0.00509091313349303 0.0625358726184485 0.935741027939111 0.984184670138276 glutamate receptor antagonist, sigma receptor agonist CHRNA2, CHRNA3, CHRNA4, CHRNA7, CHRNB2, CHRNB4, CYBA, CYBB, GRIN3A, NCF1, NCF2, NCF4, OPRD1, OPRK1, OPRM1, PGRMC1, RAC1, RAC2, SIGMAR1, SLC6A2, SLC6A4 Launched diazoxide 0.145625022207165 0.0299539161429333 0.00125319874779461 0.0278283772736284 potassium channel activator ATP1A1, CA1, CA2, KCNJ11, KCNJ8, KCNMA1, SLC12A3 Launched diclofenac -0.0367215483319629 0.0346011523797723 0.294352952274981 0.627496603686975 cyclooxygenase inhibitor AKR1C3, ALOX5, ASIC1, ASIC3, KCNQ2, KCNQ3, PLA2G2A, PPARG, PTGS1, PTGS2, SCN4A Launched diclofenamide 0.162790950408993 0.0577023806154907 0.022451754900843 0.154355814943296 carbonic anhydrase inhibitor CA1, CA12, CA2, CA4, CA7 Launched dicycloverine -0.0939125928055374 0.156194122256789 0.564313789387675 0.846178360484973 acetylcholine receptor antagonist CHRM1, CHRM2, CHRM3 Launched dienestrol -0.036957940369993 0.140077970603376 0.798573497081988 0.940886055567534 estrogen receptor agonist ESR1 Launched diethylcarbamazine -0.00416413375007981 0.0756817707169773 0.957470525379591 0.985508830066777 lipoxygenase inhibitor ALOX5, PTGS1 Launched diethyltoluamide 0.0578293370648687 0.10003523708207 0.579108223884654 0.862390405604403 ionotropic receptor IR40a activator Launched diflunisal 0.078236983870614 0.0550577610678498 0.193101429662561 0.506494565886244 prostanoid receptor antagonist PTGS1, PTGS2 Launched digitoxin 0.190367227169728 0.0812423977485087 0.0471793834612013 0.23087924768806 ATPase inhibitor ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2 Launched digoxin 0.169737986822548 0.0596257788769872 0.0111511832067098 0.101095891709182 ATPase inhibitor ATP1A1 Launched dihydroergocristine 0.00881256734719228 0.0212245003194644 0.68318338312138 0.910739845909459 adrenergic receptor antagonist, prolactin inhibitor ADRA1A, ADRB1, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR2A, HTR3A, HTR4, HTR5A, HTR6, HTR7 Launched dihydroergotamine -0.0460906590634773 0.0302705570120024 0.16635214393601 0.454438803798703 serotonin receptor agonist ADRA2A, DRD2, HTR1B, HTR1D, HTR1E, HTR1F, HTR2B, HTR7 Launched diloxanide -0.0339785953084576 0.0815192371121327 0.687771828540895 0.910739845909459 protein synthesis inhibitor Launched diltiazem -0.0192884178623364 0.016815779249906 0.26181021419732 0.595023214084818 calcium channel blocker CACNA1C, CACNA1S, CACNA2D1, CACNG1, HTR3A, KCNA5 Launched dimercaptosuccinic-acid -0.0214157648439886 0.0694824457398241 0.765788838331156 0.930450355851552 chelating agent DNMT1 Launched dinaciclib 0.167339670687918 0.0491289660626902 0.00141739700709005 0.0285207934353486 CDK inhibitor CDK1, CDK2, CDK5, CDK9 Phase 3 diphenidol 0.166909558943697 0.037803701671709 0.00224090344160741 0.0382022678483128 acetylcholine receptor agonist CHRM1, CHRM2, CHRM3, CHRM4 Launched dipyridamole -0.00305934796129342 0.074850229684099 0.96839885675005 0.987551368132004 phosphodiesterase inhibitor ADA, PDE10A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, SLC29A1 Launched disopyramide -0.016534792151034 0.159722924062185 0.920097026799259 0.979483776428112 sodium channel blocker CHRM1, CHRM2, CHRM3, KCND2, KCND3, KCNH2, SCN5A Launched dmp-543 -0.0484311123204736 0.0701108245155821 0.499028504034704 0.800894314794982 acetylcholine release enhancer Phase 2 dobutamine 0.0545735415755646 0.0761809583291479 0.494142839403707 0.800894314794982 adrenergic receptor agonist ADRB1, ADRB2 Launched docetaxel 0.107308469435072 0.0211047672928934 9.18441294938497e-05 0.00618738915867171 tubulin polymerization inhibitor BCL2, MAP2, MAP4, MAPT, NR1I2, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 Launched doconexent -0.000777108409787842 0.0231531429030271 0.973308558469208 0.989492436074094 PPAR receptor agonist FFAR1, PTGS1, PTGS2 Launched domperidone 0.0495427314867838 0.0791041720818981 0.548569157047868 0.838091767712021 dopamine receptor antagonist DRD2, DRD3 Launched donepezil 0.155397141770402 0.0418656300344514 0.00594089996285868 0.0662330063426812 acetylcholinesterase inhibitor ACHE Launched dopamine -0.0284268732879295 0.00729243354222413 0.000145017931675259 0.00741444023921543 dopamine receptor agonist DBH, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR7, SLC6A2, SLC6A3, SLC6A4 Launched doramapimod 0.06252183685711 0.0280934847132822 0.0281456888307917 0.170736715333847 p38 MAPK inhibitor MAPK11, MAPK12, MAPK13, MAPK14 Phase 2 dosulepin -0.0224050338413911 0.0635411759744583 0.733492947046864 0.919653011114989 norepinephrine reuptake inhibitor, serotoninƒ__norepinephrine reuptake inhibitor (SNRI), tricyclic antidepressant CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HRH1, SLC6A2, SLC6A4 Launched dovitinib 0.155247416189066 0.0522644045665707 0.0178595913403839 0.129247042594883 EGFR inhibitor, FGFR inhibitor, FLT3 inhibitor, PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor CSF1R, EGFR, FGFR1, FGFR2, FGFR3, FLT1, FLT3, FLT4, INSR, KDR, KIT, PDGFRA, PDGFRB Phase 3 doxepin 0.00165966146967334 0.0348400581736499 0.962369907895424 0.986636188276503 histamine receptor antagonist HRH1, SLC6A2, SLC6A4 Launched doxercalciferol -0.0214032603416994 0.0473270489692803 0.656812385706996 0.903397140476511 vitamin D receptor agonist VDR Launched doxylamine -0.010741157833114 0.0826236211164884 0.89977493185237 0.964044569841825 histamine receptor antagonist HRH1 Launched dppe 0.101474750823871 0.0212573713234938 0.000176426237262921 0.00741444023921543 histamine receptor antagonist ABCB1, HRH1 Phase 3 droperidol -0.0739164057241278 0.0522294350574914 0.175060455134993 0.471976717275716 dopamine receptor antagonist ADRA1A, DRD2, DRD3, DRD4, HTR2A Launched duloxetine 0.00664280053423913 0.0987612385678941 0.948024396145086 0.984184670138276 norepinephrine reuptake inhibitor, serotoninƒ__norepinephrine reuptake inhibitor (SNRI) HTR2A, HTR2C, HTR6, SLC6A2, SLC6A3, SLC6A4 Launched dup-697 -0.140520197443086 0.0443544219122556 0.0132320394353052 0.110178207591459 cyclooxygenase inhibitor PTGS2 Phase 1 dydrogesterone -0.0114728685059138 0.0302335224005755 0.714209926388158 0.916925879326847 progesterone receptor agonist PGR Launched e-4031 0.194135005493978 0.0650009680694522 0.0174227971356844 0.127201837495041 potassium channel blocker KCNH1, KCNH2 Phase 1 econazole 0.113588425578124 0.0845505914715743 0.215990404682377 0.541617276179213 lanosterol demethylase inhibitor, sterol demethylase inhibitor NPY1R, NPY2R, TRPM2, TRPV5 Launched ellagic-acid -0.0742434003902419 0.0582324302581714 0.21072606833975 0.538232217895646 glutathione transferase inhibitor, non-nucleoside reverse transcriptase inhibitor CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, GSK3B, PRKACA, PRKCA, PRKCB, SQLE, SYK Phase 2 elvitegravir 0.10297720336014 0.0779524670412901 0.223025978266607 0.549574790413354 HIV integrase inhibitor Launched emetine 0.0861752277544512 0.0854576222253845 0.342787009328089 0.672520521029605 protein synthesis inhibitor RPS2 Phase 2 enalapril -0.0184699440730919 0.128520820611452 0.889282244065761 0.957777873830617 angiotensin converting enzyme inhibitor ACE Launched enrofloxacin -0.0227913983117532 0.149188883229777 0.882363495631888 0.957572900671529 bacterial DNA gyrase inhibitor Launched entecavir 0.0218549383704992 0.0396946511781172 0.589086661093671 0.864762447335015 DNA replication inhibitor, nucleoside reverse transcriptase inhibitor Launched entinostat 0.0901929990102614 0.0427668445839561 0.0366921690998464 0.20047046031373 HDAC inhibitor HDAC1, HDAC2, HDAC3, HDAC9 Phase 3 enzastaurin 0.00192661255283448 0.04760702463813 0.96794913093035 0.987551368132004 PKC inhibitor AKT1, GSK3B, PRKCA, PRKCB, PRKCD, PRKCG Phase 3 ephedrine 0.0243644651083959 0.0150331555637524 0.114054822585047 0.37210990544334 adrenergic receptor agonist ACHE, ADRA1A, ADRB2, SLC18A2, SLC6A2 Launched epicatechin-gallate-(-) 0.11338935252793 0.0647171202530699 0.117859808965726 0.375715717438561 bacterial DNA gyrase inhibitor BACE1, FASN Phase 2 epigallocatechin-gallate-(-) 0.00920815625903606 0.0308161967904493 0.765471135089208 0.930450355851552 bacterial DNA gyrase inhibitor ELANE, EP300, FASN, KAT2B, MMP14, MMP2 Phase 2/Phase 3 epirizole 0.0915530933940312 0.0862219106967417 0.319312781204241 0.650804793690333 cyclooxygenase inhibitor PTGS1, PTGS2 Launched epirubicin -0.00502718708561784 0.0526389445685861 0.925031907889375 0.980914298211741 topoisomerase inhibitor CHD1, TOP2A Launched eplerenone -0.0106977209859775 0.0600478482179021 0.863031216117165 0.953146925430604 cytochrome P450 inhibitor NR3C2 Launched erlotinib 0.0369089237212858 0.0211788914077052 0.0994406711456188 0.35209679697483 EGFR inhibitor EGFR, NR1I2 Launched erythromycin -0.065116920587162 0.189626416023364 0.740150756857658 0.921002073012923 NFkB pathway inhibitor MLNR Launched erythromycin-estolate 0.0702112153468935 0.0681020795232835 0.317000321079738 0.650560360424836 bacterial 50S ribosomal subunit inhibitor ABCB1, ALB, CYP3A4, CYP51A1, KCNH2, MLNR, SLC47A1 Launched erythromycin-ethylsuccinate 0.0520236645690975 0.0598501003006408 0.410039459904442 0.745115758636927 cytochrome P450 inhibitor, protein synthesis inhibitor ABCB1, ALB, CYP3A4, CYP51A1, KCNH2, MLNR, SLC47A1 Launched escitalopram 0.0961197741036916 0.0602724800567373 0.1494334737865 0.428465383714786 selective serotonin reuptake inhibitor (SSRI) SLC6A4 Launched esculin 0.0343434515544641 0.0302511031422786 0.28912451983563 0.623248662635638 antioxidant Phase 1 estradiol 0.026076785836979 0.0170656774643301 0.131592318860331 0.399131114190342 estrogen receptor agonist ESR1, ESR2, GPER1, KCNMA1, NR1I2 Launched estradiol-cypionate -0.100920910961583 0.0788283373215567 0.236324805324442 0.563574933924244 estrogen receptor agonist ESR1 Launched estradiol-valerate -0.0857246518091864 0.13059861081942 0.529991789392236 0.819028660325335 estrogen receptor agonist ESR1 Launched estriol 0.114109635332725 0.0340424423775918 0.00378076869573149 0.0511333471144013 estrogen receptor agonist ESR1, ESR2 Launched estrone -0.0312846332111133 0.05356239165175 0.562150307673844 0.844761391313154 estrogen receptor agonist, estrogenic hormone ESR1, ESR2 Launched estropipate 0.0539943215669253 0.0649964378681742 0.430220770105539 0.756361256205134 estrogen receptor agonist ESR1, ESR2 Launched ethisterone -0.00218111623069266 0.0302521402632205 0.944293902282545 0.984184670138276 progestogen hormone TYR Launched etodolac -0.0737097717490523 0.0331368541425819 0.0326671294601602 0.18951184274107 cyclooxygenase inhibitor PTGS2 Launched etomidate 0.0121973872738702 0.0302768264714183 0.697600930144211 0.910909654393513 GABA receptor modulator ADRA2B, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ Launched etomoxir -0.0516861800623824 0.0455834307982662 0.27258177423845 0.606145454842914 carnitine palmitoyltransferase inhibitor CPT1A Phase 2 etoposide 0.0691491630568115 0.0690413870432345 0.323430138942176 0.652395757034951 topoisomerase inhibitor TOP2A, TOP2B Launched everolimus 0.0556531201179751 0.0222630856949318 0.0134884835960453 0.110178207591459 mTOR inhibitor MTOR Launched ex-527 0.0586949692811279 0.0243749812438279 0.0170554888027852 0.125631948770516 SIRT inhibitor SIRT1 Phase 2 exemestane -0.02760272704328 0.0959058632987366 0.780806891195884 0.933070005569882 aromatase inhibitor CYP19A1 Launched ezetimibe 0.246026035445897 0.0597228832254889 0.00334669251377205 0.0476038159286542 cholesterol inhibitor, Niemann-Pick C1-like 1 protein antagonist ANPEP, NPC1L1, SOAT1 Launched famciclovir 0.158090499200747 0.0693605702406589 0.0521318249616552 0.242987319736528 DNA polymerase inhibitor Launched fananserin 0.0356711384044787 0.0859397170402945 0.688997715479087 0.910739845909459 dopamine receptor antagonist, serotonin receptor antagonist HTR2A Phase 2 fasudil -0.136437014816441 0.0805560178477143 0.128776238810959 0.394945713825432 rho associated kinase inhibitor PKIA, PRKACA, ROCK1, ROCK2 Launched febuxostat 0.101963202372349 0.0852221737210937 0.265777161249648 0.600576931034481 xanthine oxidase inhibitor XDH Launched felbamate 0.0602574223756493 0.0688405662360861 0.406912191456397 0.742704774229043 glutamate receptor antagonist GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B Launched felodipine 0.109928227585063 0.156685640206425 0.502833750130642 0.802425539771869 calcium channel blocker CFTR Launched fenbendazole 0.174978697842434 0.0530583462434542 0.0108936497732102 0.0998584562544268 tubulin polymerization inhibitor TUBB Launched fenbufen -0.088566579350028 0.0807168124796933 0.287831428716344 0.623248662635638 cyclooxygenase inhibitor PTGS1, PTGS2 Launched fenobam 0.0425425821039571 0.0430063765620604 0.327052399831597 0.653530000444668 glutamate receptor antagonist GRM5 Phase 2 fenofibrate -0.192975455009965 0.134064246276722 0.187985853824452 0.497077978862734 PPAR receptor agonist MMP25, PPARA Launched fenoldopam 0.0642151498453749 0.118899504380112 0.603847351671588 0.875452476146448 dopamine receptor agonist DRD1, DRD4 Launched fenretinide 0.190286838333847 0.0675603176505148 0.00650213200610777 0.0705823540136699 apoptosis stimulant, retinoid receptor agonist RARA Phase 3 fexofenadine -0.0382103428928557 0.113220938925334 0.744435823517193 0.922253610491613 histamine receptor antagonist HRH1 Launched finasteride 0.0273433096377442 0.0605003287539896 0.657016102164735 0.903397140476511 5 alpha reductase inhibitor AKR1D1, SRD5A1, SRD5A2 Launched fipronil 0.00185237421320501 0.0317333776572286 0.954883216045597 0.985508830066777 chloride channel blocker, GABA gated chloride channel blocker Launched fk-866 -0.0387354589439104 0.0207422841092446 0.0659647441089337 0.279058862265764 niacinamide phosphoribosyltransferase inhibitor NAMPT Phase 2 fk-888 -0.090666887621365 0.0862759635634522 0.308017381440361 0.638478240422859 tachykinin antagonist TACR1, TACR2 Phase 2 flavoxate 0.0401913977625595 0.0346772738160388 0.279874327856204 0.615860300715999 acetylcholine receptor antagonist CHRM1, CHRM2 Launched flecainide -0.0335615586729787 0.0302605596922064 0.299617683728882 0.633813876191754 sodium channel blocker KCNA5, KCNA7, SCN5A Launched floxuridine 0.0629430715009897 0.0542219906617559 0.261748872698511 0.595023214084818 DNA synthesis inhibitor TYMS Launched flucloxacillin 0.0951296261911121 0.0529810337131242 0.110302002466663 0.368417619574887 bacterial cell wall synthesis inhibitor Launched fluconazole -0.204685663555583 0.051630092840081 0.0041509872119018 0.0535088195284216 sterol demethylase inhibitor CYP51A1 Launched fludarabine 0.0533043393350063 0.0598176444068794 0.381040610504651 0.716078596050882 ribonucleotide reductase inhibitor ADA, DCK, POLA1, RRM1, RRM2 Launched fludroxycortide 0.0385724476649157 0.064814448037359 0.559601779908029 0.842466183255701 glucocorticoid receptor agonist NR3C1, SERPINA6 Launched flumazenil 0.00571846183367055 0.054484680459407 0.918994969224584 0.979483776428112 benzodiazepine receptor antagonist GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ Launched flunarizine 0.0639915251170912 0.0438887447798182 0.156804195830599 0.441513520683427 calcium channel blocker CACNA1G, CACNA1H, CACNA1I, CALM1, HRH1 Launched flunisolide 0.0667979940848211 0.0212244086856932 0.0058779085376392 0.0662330063426812 cytochrome P450 inhibitor NR3C1 Launched fluoxetine -0.012532424146064 0.0150112326327668 0.409453760283892 0.745115758636927 selective serotonin reuptake inhibitor (SSRI) ANO1, HTR2B, SLC6A4 Launched flupentixol 0.0201715455135402 0.0577572684297342 0.731192594516834 0.919653011114989 dopamine receptor antagonist ADRA1A, CHRM1, DRD1, DRD2, DRD3, DRD5, HTR2A Launched fluphenazine -0.116528970314157 0.0679191879801811 0.124555072756611 0.386308026406782 dopamine receptor antagonist CALM1, DRD1, DRD2, DRD5, HRH1, HTR2A, HTR6, HTR7 Launched flupirtine 0.0632435240250523 0.0780924389737303 0.429214661494883 0.756361256205134 glutamate receptor antagonist ADRA2A, KCNQ1, KCNQ2 Launched fluspirilene 0.0641604743796289 0.022160029358426 0.00587659257983852 0.0662330063426812 dopamine receptor antagonist CACNG1, DRD2, HRH1, HTR1A, HTR1D, HTR1E, HTR2A Launched flutamide -0.0747932518068236 0.0440843446689523 0.108005660595595 0.365996558325368 androgen receptor antagonist AHR, AR Launched fluticasone-propionate 0.00524571669063766 0.0630831676709875 0.935770910299878 0.984184670138276 glucocorticoid receptor agonist NR3C1, NR3C2, PGR, PLA2G4A Launched fluvastatin 0.0330417975490786 0.0296395241307965 0.270993274644183 0.605879272578458 HMGCR inhibitor HMGCR Launched fluvoxamine 0.125237080769478 0.0275167137440393 0.000282966621642543 0.0101498896893521 selective serotonin reuptake inhibitor (SSRI) SLC6A4 Launched formestane 0.00869471773286828 0.0524314741760573 0.872404871892397 0.954103537306562 aromatase inhibitor CYP19A1 Launched formoterol 0.0495841572103313 0.0621762247200965 0.436171590091711 0.760764401322752 adrenergic receptor agonist ADRB2 Launched forskolin 0.0158693453026496 0.0215932481985618 0.465158035395994 0.778408477082546 adenylyl cyclase activator ADCY2, ADCY5, GNAS Launched foxy-5 0.00338416588699286 0.0148932091765316 0.821567932401489 0.946731910237955 WNT5a peptide mimetic WNT5A Phase 2 fpl-55712 0.112758684596797 0.0397936746437904 0.0114647381912357 0.102808793562711 leukotriene receptor antagonist Phase 1 fr-139317 0.0533750485480536 0.0459065657416421 0.261018151079998 0.595023214084818 endothelin receptor antagonist EDNRA Phase 1 fulvestrant 0.0448329606327968 0.0473103854231925 0.344819612600634 0.672520521029605 estrogen receptor antagonist ESR1, ESR2, GPER1 Launched gabexate 0.068630751458768 0.0301980704230282 0.0526691156856797 0.244112474385875 serine protease inhibitor PRSS1, TPSAB1 Launched gamma-linolenic-acid -0.057642011761058 0.138679713045173 0.688592424158681 0.910739845909459 cyclooxygenase inhibitor, prostanoid receptor agonist PTGS1, PTGS2 Phase 2 gavestinel 0.0505351285290382 0.0301587614802004 0.132337574786199 0.399921242485766 glutamate receptor antagonist GLRB, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B Phase 3 gdc-0068 0.11883750730124 0.0163768311780392 6.6218162608471e-11 5.46299841519886e-08 AKT inhibitor AKT1, AKT2, AKT3, PRKG1 Phase 3 gdc-0941 0.110538207981201 0.0272633516408499 0.000266611488971999 0.00999793083644996 PI3K inhibitor PIK3CA, PIK3CB, PIK3CD, PIK3CG Phase 2 gefitinib 0.0394699551825437 0.0540359689217016 0.469983605919287 0.783306009865478 EGFR inhibitor EGFR Launched gemfibrozil -0.0672330009091196 0.0205228239829238 0.00237930185381958 0.0382022678483128 lipoprotein lipase activator LPL, PPARA, SLCO1B1, SLCO1B3, SLCO2B1 Launched genistein -0.0246136796606666 0.0320872316283635 0.445941438364314 0.766302744708207 tyrosine kinase inhibitor CFTR, ESR1, ESR2, ESRRA, ESRRB, ESRRG, NCOA1, NCOA2, PPARG, PTK2B, TOP2A, TRPC5 Phase 2/Phase 3 givinostat 0.0494764638154228 0.0213314902537888 0.0330784307329867 0.18951184274107 HDAC inhibitor HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 Phase 3 glimepiride 0.0410522396284229 0.0213539694407439 0.0714675872046891 0.289023330607199 insulin secretagogue ABCC8, KCNJ1, KCNJ11 Launched glipizide 0.00363947002630074 0.0763733219989084 0.963160420593765 0.986636188276503 sulfonylurea ABCC8, KCNJ10, KCNJ11, PPARG Launched gliquidone 0.041581741570859 0.0261837804359591 0.130693902254716 0.397868890627825 sulfonylurea ABCC8, KCNJ10, KCNJ8 Launched glucosamine -0.0567575143872379 0.0366542775193111 0.130508515319475 0.397868890627825 glycosylated protein precursor IL1B Launched gr-235 0.00244693006953528 0.0667552127001631 0.971186868743107 0.989171810756868 estrogen receptor agonist, FXR antagonist, progesterone receptor agonist NR1H4 Launched gr-79236 0.0643958017042702 0.0301225999964889 0.0649996977607617 0.277848448977349 adenosine receptor agonist ADORA1, ADORA2A Phase 1 guanaben-acetate -0.0888406495485238 0.0383961226425604 0.0334523077306568 0.190332095708909 adrenergic receptor agonist ADRA2A, ADRA2B, ADRA2C Launched guanfacine 0.077479197756147 0.137163271980138 0.587648606774845 0.864762447335015 adrenergic receptor agonist ADRA2A, ADRA2B, ADRA2C Launched gw-311616 0.10675011246611 0.0791603762074058 0.214418689837463 0.540936398676843 elastase inhibitor, leukocyte elastase inhibitor ELANE Phase 1 gw-501516 -0.0398540650526759 0.0574354405390197 0.49712227413971 0.800894314794982 PPAR receptor agonist PPARA, PPARD Phase 2 gw-5074 0.00943008534563886 0.0108875119856754 0.388202541999395 0.722302117829717 leucine rich repeat kinase inhibitor, RAF inhibitor NTRK1, RAF1 Phase 1/Phase 2 ha-1004 0.0693349462135369 0.0301779340696021 0.0506651852606384 0.240222861149579 calcium channel blocker Phase 2 halcinonide 0.0730997915827509 0.0421802358814622 0.101188961242528 0.353732597563922 glucocorticoid receptor agonist NR3C1 Launched hesperidin 0.0798674978766237 0.0468488290618244 0.126630901069983 0.391275256115116 flavanone glycoside AURKB, CACNA1B Launched hexachlorophene 0.0630437237047983 0.0199517444387294 0.00324929561673242 0.0476038159286542 potassium channel activator GLUD1, SDHD Launched hexylcaine -0.0347841249397657 0.0732438998433461 0.647546937938857 0.899954602722867 sodium channel blocker SCN5A Launched hmn-214 0.0814232755126074 0.024712809360938 0.00128179192290652 0.0278283772736284 PLK inhibitor PLK1 Phase 1 huperzine-a 0.011971188259948 0.08368434084417 0.887931235168145 0.957572900671529 acetylcholinesterase inhibitor ACHE Phase 2 hydralazine 0.0504186264282482 0.0395790006006266 0.219849633915212 0.547963589063595 vasodilator Launched hydrocortisone 0.194148565424941 0.0296716278144628 0.000179744005799162 0.00741444023921543 glucocorticoid receptor agonist ANXA1, NOS2, NR3C1, NR3C2 Launched hydrocortisone-valerate -0.0699441324726291 0.107646122419727 0.534055561138893 0.82200716033505 glucocorticoid receptor agonist NR3C1 Launched hydroquinidine -0.0789230729803711 0.107224893668236 0.482720349587757 0.791522144000251 antiarrhythmic Launched hydroxychloroquine -0.0273114935685711 0.0347493788889716 0.437182013113089 0.760918060798098 antimalarial agent TLR7, TLR9 Launched hyoscyamine 0.105432249390559 0.0556706366560384 0.0948609503948275 0.343246859981284 acetylcholine receptor antagonist CHRM1, CHRM2, CHRM3, CHRM4 Launched hypericin 0.0203198712188783 0.0634301951932591 0.756910268653891 0.927861770638128 tyrosine kinase inhibitor Phase 3 i-bet-762 0.0355295939492294 0.0866224231075042 0.682504100727725 0.910739845909459 bromodomain inhibitor BRD2, BRD3, BRD4 Phase 2 ib-meca -0.0420285701124318 0.0433840174085021 0.361038451931087 0.696330646907309 adenosine receptor agonist ADORA1, ADORA2A, ADORA2B, ADORA3 Phase 3 ibrutinib -0.0965863818740054 0.0283756174990305 0.00093605316232693 0.0233240036089873 Bruton's tyrosine kinase (BTK) inhibitor BLK, BMX, BTK Launched ibudilast 0.0977757256491934 0.0301121455300847 0.0117528246268654 0.104258928141548 leukotriene receptor antagonist, phosphodiesterase inhibitor IL1B, IL6, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A Launched ibuprofen-(s) 0.00280640109703376 0.0514490562208024 0.957836836243611 0.985508830066777 cyclooxygenase inhibitor ASIC1, PTGS1, PTGS2, SLC5A8 Launched icariin -0.0513242305791827 0.103209127016705 0.632366460593877 0.896431567177881 phosphodiesterase inhibitor PDE5A Phase 3 ici-162846 -0.0684120287553823 0.107409597615628 0.541965242230604 0.829538636067251 histamine receptor antagonist HRH2 Phase 1 ici-89406 0.023438451596181 0.103980392196607 0.827310264554884 0.947382469024535 adrenergic receptor antagonist ADRB1, ADRB2 Phase 1 icilin 0.0989597951722266 0.0325617166427371 0.0160841681054637 0.121367312788305 TRPV agonist TRPA1, TRPM8 Phase 1 icosapent -0.0640675673972554 0.0147316829863972 0.000112497984703122 0.00618738915867171 platelet aggregation inhibitor ACSL3, ACSL4, FADS1, FFAR1, PPARD, PPARG, PTGS1, PTGS2, SLC8A1, TRPV1 Launched idelalisib -0.0313309790662536 0.0207536874188073 0.134077998281994 0.402233994845982 PI3K inhibitor PIK3CA, PIK3CB, PIK3CD, PIK3CG Launched ikk-2-inhibitor-v 0.158501135393338 0.0668769166780942 0.0452434161939883 0.22759645341488 IKK inhibitor, NFkB pathway inhibitor IKBKB Phase 1 ilomastat -0.0385257299152133 0.0916435869813115 0.685267548826169 0.910739845909459 matrix metalloprotease inhibitor ACAN, ADAM28, MMP1, MMP12, MMP13, MMP14, MMP2, MMP3, MMP8, MMP9 Phase 3 iloperidone -0.106054948229695 0.0209115387355737 9.43586776761343e-05 0.00618738915867171 dopamine receptor antagonist, serotonin receptor antagonist ADRA1A, ADRA2C, DRD1, DRD2, DRD3, DRD4, HRH1, HTR1A, HTR2A, HTR6, HTR7 Launched iloprost -0.0928260009266725 0.0211681278620149 0.00040382976545341 0.0133263822599625 platelet aggregation inhibitor, prostanoid receptor agonist PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, TBXA2R Launched imatinib 0.00728529872451064 0.0333085298787347 0.827706907677352 0.947382469024535 Bcr-Abl kinase inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor ABL1, CSF1R, DDR1, KIT, NTRK1, PDGFRA, PDGFRB, RET Launched imiquimod -0.0561922122763687 0.0705434322890941 0.431075808973236 0.756361256205134 interferon inducer, toll-like receptor agonist TLR7, TLR8 Launched immethridine -0.0393215960855391 0.0302492714011656 0.229830141398655 0.554088571015178 histamine receptor agonist HRH3 Phase 1 indole-3-carbinol 0.0438234561143068 0.0302148082519824 0.18499706078094 0.493924191405422 aryl hydrocarbon receptor agonist, indoleamine 2,3-dioxygenase inhibitor AHR Phase 2/Phase 3 iniparib 0.0860741173600921 0.0341108394215282 0.0130936035851882 0.110178207591459 PARP inhibitor PARP1 Phase 3 iobenguane -0.0207643963033026 0.0593314076684327 0.735394069201062 0.920637491791921 antineoplastic agent Launched ioxaglic-acid 0.0220642944115598 0.118519382276088 0.856948472859416 0.950245282404594 radiopaque medium Launched ipratropium 0.127598729219522 0.0592861299753744 0.0460373857427578 0.230186928713789 acetylcholine receptor antagonist CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 Launched irbesartan -0.0888151059437444 0.0452843683792359 0.0854893566839168 0.322048946412015 angiotensin receptor antagonist AGTR1, JUN, SLC10A1 Launched irinotecan 0.136226129469523 0.0803530445945581 0.108246254825927 0.365996558325368 topoisomerase inhibitor TOP1, TOP1MT Launched irsogladine 0.040293326069057 0.0523373443364102 0.463497153528239 0.777779814842238 phosphodiesterase inhibitor PDE4A Launched isamoltane 0.054256052273851 0.0954364129436181 0.585292742690001 0.864762447335015 adrenergic receptor antagonist HTR1A, HTR1B Phase 1 isocarboxazid 0.0247744189541541 0.0241467055273501 0.319272061487194 0.650804793690333 monoamine oxidase inhibitor MAOA, MAOB Launched isotretinoin -0.00719917517104766 0.0392337016058675 0.855110103458537 0.949785715745155 retinoid receptor agonist RARA, RARB, RARG Launched isoxsuprine -0.124598947645306 0.0803168563142675 0.159418823423351 0.445731233179196 adrenergic receptor agonist ADRB2 Launched ispinesib 0.18807034801965 0.0623384277431986 0.0077691051975664 0.0811330606074972 kinesin inhibitor KIF11 Phase 2 isradipine 0.0354977160293388 0.0149698070241458 0.0233605050435882 0.157451122234862 calcium channel blocker CACNA1D, CACNA1F, CACNA2D1 Launched jnj-26481585 0.0521001623184495 0.0463951507111069 0.277061669469445 0.614451283097559 HDAC inhibitor HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, MDM2 Phase 2 jnj-38877605 0.0634937961280529 0.0277101521843548 0.0239015650029711 0.157451122234862 tyrosine kinase inhibitor MET Phase 1 jte-907 0.0516499644807771 0.0622655995148101 0.430869701722659 0.756361256205134 cannabinoid receptor inverse agonist CNR2 Phase 1 ketanserin 0.051771911357392 0.0208556553903356 0.0237890372770602 0.157451122234862 serotonin receptor antagonist ADRA1A, ADRA1B, ADRA1D, DRD1, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, SLC18A1, SLC18A2 Launched ketoprofen 0.117542648672258 0.122863704727484 0.366736391386956 0.702593767449779 cyclooxygenase inhibitor PTGS1, PTGS2, SLC5A8 Launched ketorolac 0.0484499793438165 0.0617134503530199 0.455025562068432 0.773600034208035 cyclooxygenase inhibitor PTGS1, PTGS2 Launched ketotifen -0.114984372053627 0.118747361594703 0.361247899244034 0.696330646907309 histamine receptor agonist, leukotriene receptor antagonist, phosphodiesterase inhibitor HRH1 Launched kw-2449 0.00942967553826177 0.0214709619512549 0.661414775592475 0.906423903428226 Abl kinase inhibitor, Aurora kinase inhibitor, FLT3 inhibitor ABL1, AURKA, AURKB, FLT3 Phase 1 l-368899 -0.00646506945729845 0.0638991164516544 0.921900401968774 0.979483776428112 oxytocin receptor antagonist AVPR1A, AVPR2, OXTR Phase 1 l-655240 -0.0655082250561833 0.0900493960297599 0.47683837664146 0.786783321458409 thromboxane receptor antagonist PTGES Phase 1 labetalol -0.0235598354280778 0.0301844097575401 0.457549940015168 0.773798829426204 adrenergic receptor antagonist ADRA1D, ADRB1, ADRB2 Launched lamotrigine -0.0285144179658421 0.0431494028393697 0.517577308141736 0.810624673563108 serotonin receptor antagonist, sodium channel blocker SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A Launched lansoprazole 0.0632406287956551 0.0150110789025323 0.000167891203258065 0.00741444023921543 ATPase inhibitor ATP4A, ATP4B Launched lapatinib -0.00157661146578979 0.0285337775864004 0.956250152584008 0.985508830066777 EGFR inhibitor EGFR, ERBB2 Launched lasalocid 0.174652865008877 0.0422802191563912 0.00329463980584507 0.0476038159286542 bacterial permeability inducer Launched latrunculin-b 0.00834411718547331 0.0330384278969773 0.802087225109412 0.94111784575798 actin polymerization inhibitor ACTA1, MKL1, SPIRE2 Phase 1 leflunomide 0.0354558068926708 0.0671682508241244 0.611916079186024 0.881031004063647 dihydroorotate dehydrogenase inhibitor, PDGFR tyrosine kinase receptor inhibitor AHR, DHODH, PTK2B Launched lenalidomide -0.028684914591717 0.0290862577478531 0.329426476606167 0.654883959518284 anticancer agent TNF Launched lestaurtinib 0.132647560654917 0.0898481639307889 0.158132931420333 0.443740368781547 FLT3 inhibitor, growth factor receptor inhibitor, JAK inhibitor FLT3, NTRK1 Phase 3 levcromakalim 0.0897091564691209 0.0389566188369988 0.0502510067260394 0.240215519595603 potassium channel activator KCNJ5 Phase 3 levocabastine -0.00449515647945757 0.0618077180032645 0.942871349981633 0.984184670138276 histamine receptor antagonist HRH1, NTSR2 Launched levomepromazine -0.00234061800156414 0.0302529880417453 0.940230691163958 0.984184670138276 dopamine receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HTR2A, HTR2C Launched levonorgestrel -0.0814860086148705 0.0491786197630872 0.115870203784011 0.372140570603971 estrogen receptor agonist, glucocorticoid receptor antagonist, progesterone receptor agonist, progesterone receptor antagonist PGR Launched licochalcone-a -0.03700701046367 0.0146441768263935 0.0161735952527789 0.121367312788305 topoisomerase inhibitor PTPN1 Phase 3 lidocaine 0.0681123729781852 0.110563751348621 0.554982994370387 0.841656195506561 histamine receptor agonist EGFR, SCN10A, SCN5A, SCN9A Launched lidoflazine 0.0211772485597766 0.0766076892760193 0.785544684544369 0.935172243505201 calcium channel blocker SCN1A, SCN3A, SLC29A1 Launched linezolid 0.10497797773015 0.0643166317779269 0.121020070316137 0.379240814410728 bacterial 50S ribosomal subunit inhibitor MAOA, MAOB Launched linifanib -0.0382163347753197 0.0473253768974498 0.430519804451539 0.756361256205134 PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor CSF1, CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RET, TEK Phase 3 lisuride 0.0430484440107715 0.0213074018078564 0.059390848744001 0.264851082236761 dopamine receptor agonist ADRA1A, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR6 Launched lonidamine 0.0238011987352499 0.0213266633957743 0.279936500325454 0.615860300715999 glucokinase inhibitor GCK Launched loperamide 0.0902224053118778 0.0535135245495001 0.0988806069839794 0.351622848111134 opioid receptor agonist CACNA1A, CALM1, OPRD1, OPRK1, OPRM1, POMC Launched lopinavir 0.0431156580280982 0.0587392853514627 0.472941225898284 0.784564160418255 HIV protease inhibitor Launched loreclezole -0.00159783556485925 0.0644100821173547 0.980497597518222 0.989492436074094 benzodiazepine receptor agonist GABRB2, GABRB3 Phase 2 losartan 0.228576646169462 0.0520170282709888 0.00230435740109142 0.0382022678483128 angiotensin receptor antagonist AGTR1 Launched losmapimod -0.134580847071302 0.0583972889484055 0.0294321639858742 0.177237483856542 p38 MAPK inhibitor MAPK14 Phase 3 lovastatin -0.0190190315383941 0.0452281581288571 0.67615742177118 0.910739845909459 HMGCR inhibitor HDAC2, HMGCR, ITGAL, NR1I2 Launched loxapine -0.0143542307672958 0.0212662697338297 0.508767638517517 0.804086785013317 dopamine receptor antagonist, serotonin receptor antagonist ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR3A, HTR5A, HTR6, HTR7, SLC6A2, SLC6A3, SLC6A4 Launched lupanine -0.0959183746413302 0.119888211522916 0.446777721460179 0.766302744708207 sodium channel blocker INS Phase 1 lypressin -0.0370426169580738 0.117394687534913 0.756193018156553 0.927861770638128 vasopressin receptor agonist AVPR1A, AVPR1B, AVPR2 Launched maprotiline -0.09847602140695 0.11457035383406 0.4150634526909 0.748148105249886 norepinephrine reputake inhibitor, tricyclic antidepressant SLC6A2 Launched masitinib -0.011129314579246 0.0556058085174296 0.841691170711853 0.947492917316845 KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, SRC inhibitor FGFR3, KIT, PDGFRA, PDGFRB Launched md-920 0.00550392976351285 0.211799934307794 0.979904669883082 0.989492436074094 NFkB pathway inhibitor AADACL2 Phase 1 mebendazole 0.0368275890861215 0.0659903569207495 0.592063655599197 0.867588838133814 tubulin polymerization inhibitor TUBA1A, TUBB, TUBB4B Launched mebeverine -0.075231185669115 0.035007639715904 0.0463312044679226 0.230260504132748 acetylcholine receptor antagonist CHRM1 Launched meclizine 0.0583871766751523 0.111362991518573 0.614284972365196 0.882900874915134 constitutive androstane receptor (CAR) agonist NR1I3 Launched meclofenamic-acid 0.0175058458803045 0.0507227942165916 0.73889703614616 0.920830898520516 cyclooxygenase inhibitor, prostanoid receptor antagonist ALOX5, CNR1, KCNQ2, KCNQ3, PTGS1, PTGS2 Launched medrysone -0.0150319694082838 0.0341009196507819 0.664906135408918 0.90969744894255 glucocorticoid receptor agonist NR3C1 Launched mefenamic-acid -0.103674462761385 0.0301118126230442 0.00878511147710996 0.0842757787048339 cyclooxygenase inhibitor KCNQ1, PTGS1, PTGS2, TRPM3 Launched meloxicam 0.0381808725165992 0.0565610412583777 0.518681211170868 0.810624673563108 cyclooxygenase inhibitor PTGS1, PTGS2 Launched melperone 0.0913398996321907 0.0306636680449456 0.00842749028123292 0.0827699938335376 dopamine receptor antagonist, serotonin receptor antagonist DRD2, HTR2A Launched menadione 0.178258977539975 0.0625253476965443 0.0214464759737917 0.149943582020154 mitochondrial DNA polymerase inhibitor, phosphatase inhibitor AOX1, BGLAP, F10, F2, F7, F9, GGCX, NQO1, NQO2, PROC, PROS1, PROZ, VKORC1, VKORC1L1 Launched mephentermine 0.0425359679525625 0.0301484669573904 0.195961132257719 0.511607386432336 adrenergic receptor agonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 Launched meptazinol -0.0155247215980848 0.0778508346210381 0.84691247044528 0.947492917316845 opioid receptor agonist BCHE Launched mepyramine 0.0135984135000788 0.0628925644533278 0.834230322668392 0.947492917316845 histamine receptor antagonist HRH1 Launched mesoridazine 0.0897180422926868 0.119608705864016 0.474676355885895 0.784785558328384 dopamine receptor antagonist DRD2, HTR2A Launched mestranol -0.0753075658249157 0.0208599638676766 0.00216078032709408 0.037928590847928 estrogen receptor agonist ESR1 Launched metaxalone -0.0547768201922959 0.0577328760466821 0.370500292029739 0.704978806691368 muscle relaxant Launched metergoline 0.0809104847053357 0.0942611937641495 0.415666506429082 0.748148105249886 dopamine receptor agonist, serotonin receptor antagonist HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 Launched metformin -0.127602009056187 0.0290087540126191 9.70990108798013e-05 0.00618738915867171 insulin sensitizer ACACB, PRKAB1 Launched methantheline -0.101446393420735 0.139871985916879 0.48894945007136 0.795627803370556 acetylcholine receptor antagonist CHRM1, HRH2 Launched methocarbamol 0.0466428971374624 0.18221007805026 0.80442232339281 0.94111784575798 muscle relaxant CA1 Launched methylergometrine 0.0200865254075136 0.069466722052002 0.775960709096642 0.932391101354502 dopamine receptor antagonist, serotonin receptor antagonist DRD1, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C Launched methysergide -0.041445738542999 0.0275652697164569 0.151047623636695 0.431191313149735 serotonin receptor antagonist HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 Launched metoclopramide 0.0621913510655333 0.0707589669933173 0.405070427093118 0.742624306956768 dopamine receptor antagonist, serotonin receptor antagonist CHRM1, DRD2, HTR3A, HTR3B, HTR4 Launched metolazone -0.0101644800992816 0.0594974576944152 0.868592246733209 0.954103537306562 carbonic anhydrase inhibitor SLC12A3 Launched metoprolol -0.0648586903945054 0.145981960216448 0.668604135069761 0.910739845909459 adrenergic receptor antagonist ADRB1, ADRB2 Launched mexiletine 0.0247779613633167 0.0948970539680856 0.800608498192011 0.940886055567534 sodium channel blocker PLAU, SCN4A, SCN5A Launched mianserin 0.0190372936355054 0.0503279759409706 0.709915979209408 0.916925879326847 serotonin receptor antagonist ADRA1A, ADRA1B, ADRA1D, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR6, HTR7 Launched midodrine 0.0015558624215616 0.113241106938299 0.989374367715705 0.991778679666411 adrenergic receptor agonist Launched midostaurin 0.173623744702161 0.0796180726758851 0.0607953513281933 0.269656800246019 FLT3 inhibitor, KIT inhibitor, PKC inhibitor FLT3, PRKCG Launched mifepristone 0.0344727496582937 0.0283914401286196 0.229277876884832 0.554088571015178 glucocorticoid receptor antagonist, progesterone receptor antagonist AR, NR1I2, NR3C1, PGR Launched milrinone 0.113284870459574 0.0749271031265543 0.169001088076026 0.460042979371849 phosphodiesterase inhibitor PDE2A, PDE3A, PDE3B, PDE5A Launched minoxidil -0.033855181220621 0.0209574493748434 0.113367711611398 0.37210990544334 KATP activator, Kir6 channel (KATP) activator, vasodilator ABCC9, KCNJ1, KCNJ10, KCNJ11, KCNJ8, PTGS1 Launched mirtazapine -0.0944608123688858 0.0459314349024463 0.0554124560723647 0.249810252785251 adrenergic receptor antagonist, serotonin receptor antagonist ADRA2A, ADRA2B, ADRA2C, HTR2A, HTR2C Launched mitomycin-c 0.169528844904433 0.054241842814542 0.0141124824315364 0.112995424353314 DNA alkylating agent, DNA synthesis inhibitor Launched mitotane 0.120777873339971 0.050761864313443 0.0445941392077306 0.227099783002332 antineoplastic agent CYP11A1, CYP11B1, ESR1 Launched mitoxantrone 0.122877459543983 0.0591484376340289 0.0477772631735623 0.231860247754052 topoisomerase inhibitor TOP2A Launched mk-1775 0.111447395798161 0.0595200636420312 0.0638767136714539 0.274470254057028 WEE1 kinase inhibitor WEE1 Phase 2 mocetinostat 0.148526401423328 0.0425821500110741 0.000672450031152897 0.0191300439896945 HDAC inhibitor HDAC1, HDAC11, HDAC2, HDAC3 Phase 2 moexipril -0.0994577800674221 0.156106761005476 0.54184932274725 0.829538636067251 angiotensin converting enzyme inhibitor ACE, ACE2 Launched mofezolac -0.11596385105082 0.0503769752288794 0.0342553559677685 0.193566223790473 cyclooxygenase inhibitor PTGS1 Launched molsidomine -0.00702910218654231 0.0355917648240403 0.848367870662734 0.947492917316845 guanylate cyclase stimulant GUCY1A3 Launched mometasone 0.0554262232483677 0.0938350656785004 0.571042499887682 0.853460257984307 glucocorticoid receptor agonist NR3C1 Launched mosapride 0.0852517120015069 0.0370907813910208 0.0344928331657589 0.193582226950688 serotonin receptor agonist HTR4 Launched motesanib -0.0341355759364518 0.0297013612452288 0.252353670988349 0.586455714268698 KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor FLT1, FLT4, KDR, KIT Phase 3 moxifloxacin 0.0144560849102563 0.0212631799867151 0.50574352161778 0.803897247100331 bacterial DNA gyrase inhibitor TOP2A Launched moxonidine -0.0757775176904809 0.0212843214047255 0.00240790051892396 0.0382022678483128 imidazoline receptor agonist ADRA2A, ADRA2B, ADRA2C Launched mycophenolate-mofetil 0.00395666848239852 0.129228623415919 0.976324580331393 0.989492436074094 dehydrogenase inhibitor, inositol monophosphatase inhibitor IMPDH1, IMPDH2 Launched mycophenolic-acid -0.0182012823453076 0.0789466604810913 0.823449614585918 0.946731910237955 dehydrogenase inhibitor, inositol monophosphatase inhibitor IMPDH1, IMPDH2 Launched nadolol 0.0208489104428863 0.0564020189249252 0.71620897203021 0.916925879326847 adrenergic receptor antagonist ADRB1, ADRB2, ADRB3 Launched nafcillin 0.0710703981920446 0.0532740679369358 0.199783922798064 0.516500158594801 bacterial cell wall synthesis inhibitor CYP1A2, CYP3A4, SLC22A6 Launched naftidrofuryl 0.019279325473287 0.113585189625216 0.869432590960818 0.954103537306562 adrenergic receptor antagonist Launched naftifine -0.0215825364681511 0.0302920355165336 0.496417542392143 0.800894314794982 fungal squalene epoxidase inhibitor Launched nalbuphine -0.0873258235605127 0.119745336910181 0.486640337598447 0.795006492116275 opioid receptor agonist, opioid receptor antagonist OPRD1, OPRK1, OPRM1 Launched naloxone 0.0215410034981587 0.0935965391693498 0.820723807499534 0.946731910237955 opioid receptor antagonist CREB1, ESR1, OPRD1, OPRK1, OPRM1, TLR4 Launched naltrexone 0.177994777608041 0.10271842755936 0.121357060611433 0.379240814410728 opioid receptor antagonist OPRD1, OPRK1, OPRM1, SIGMAR1 Launched naphazoline -0.0427977034010428 0.0430944217297621 0.349738598989028 0.680329073675691 adrenergic receptor agonist ADRA1A, ADRA2A Launched naproxen -0.0943259084406573 0.0700559083308932 0.215063198504248 0.540936398676843 cyclooxygenase inhibitor PTGS1, PTGS2 Launched naringenin -0.0194579455042493 0.0679882870590195 0.778186696373816 0.932391101354502 aromatase inhibitor, TRPV antagonist CYP19A1, CYP1B1, ESR2, GLO1, HSD17B1 Phase 1 nateglinide 0.079883800014381 0.10054217960634 0.449812181200602 0.768312731864382 insulin secretagogue ABCC8, KCNJ10, KCNJ11, PPARG Launched neca 0.0389862093806833 0.124888603709296 0.762894284488866 0.929845447665778 adenosine receptor agonist ADORA1, ADORA2A, ADORA2B, ADORA3 Launched nefopam 0.0571648835008343 0.153360737563023 0.71901814672602 0.916925879326847 cyclooxygenase inhibitor Launched nelfinavir -0.0608572960455226 0.0332380466640376 0.0846930607500637 0.320512729902764 HIV protease inhibitor CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A7 Launched nemonapride -0.020485014474801 0.0202240437238416 0.313851836019926 0.646708347574042 dopamine receptor antagonist DRD2, DRD3, DRD4 Launched nicergoline 0.0315087106198366 0.0363604675024308 0.398246500840039 0.73337804284159 adrenergic receptor antagonist ADRA1A Launched niclosamide 0.163879520140862 0.0552403015829676 0.00485195894738781 0.0580125526318108 DNA replication inhibitor, STAT inhibitor STAT3 Launched nicotinamide -0.0792068265745077 0.0449518798855872 0.0867961524880363 0.32401278643724 protein synthesis stimulant BST1, LDHA, PARP1, SIRT5 Launched nifedipine 0.0312019956555532 0.0958155315194292 0.753046046323494 0.927258191368481 calcium channel blocker CACNA1C, CACNA1D, CACNA1F, CACNA1H, CACNA1S, CACNA2D1, CACNB2, CALM1, GLRA1, GLRA3, GLRB, KCNA1, KCNA5, NR1I2, TRPM3 Launched nifurtimox -0.111880250792344 0.16618856628057 0.519782366442284 0.810624673563108 DNA inhibitor Launched nilotinib -0.0112156910579728 0.0133668757402654 0.4059679544697 0.742624306956768 Abl kinase inhibitor, Bcr-Abl kinase inhibitor ABL1, KIT Launched nilutamide 0.0207921089724204 0.130812609411068 0.8776509506793 0.955226958193169 androgen receptor antagonist AR Launched nimesulide -0.0547638175385827 0.028089039588315 0.0679101480488689 0.280129360701584 cyclooxygenase inhibitor LTF, PLA2G2E, PTGS1, PTGS2 Launched nimodipine 0.00419827255886708 0.0274228904086877 0.879024310151392 0.955461206686296 calcium channel blocker CFTR, NR3C2 Launched nisoxetine 0.0814391001428668 0.0360197802847846 0.0300838503743441 0.179849105498796 norepinephrine reuptake inhibitor SLC6A2, SLC6A3, SLC6A4 Phase 1 nitrendipine -0.0201015506643275 0.0580122096312217 0.73061448996702 0.919653011114989 calcium channel blocker CACNA1D, CACNA2D1, KCNN4 Launched nizatidine -0.00715813853684756 0.0416474153180087 0.865565431457746 0.954103537306562 histamine receptor antagonist HRH2 Launched no-asa 0.209485667362702 0.0771919984567367 0.0102512309298737 0.0961052899675659 cyclooxygenase inhibitor PTGS2 Phase 2 nomegestrol-acetate -0.113857169367566 0.108407474875097 0.324282452325748 0.652519568704249 progesterone receptor agonist PGR Launched nonoxynol-9 0.0635973255611963 0.0301050939277592 0.0676086775851365 0.280129360701584 membrane integrity inhibitor Launched norepinephrine 0.014941042840601 0.0148194221885984 0.320274843925182 0.650804793690333 adrenergic receptor agonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, PAH, SLC18A1, SLC18A2 Launched noretynodrel 0.0590974965020646 0.0171058528683304 0.00190219843449428 0.0348736379657285 progestogen hormone PGR Launched norgestimate -0.0412668845863388 0.102504706246372 0.69779657447979 0.910909654393513 progesterone receptor agonist ESR1, PGR Launched norgestrel 0.0630011854051038 0.0301976397912255 0.0704226077283394 0.288720073076173 progesterone receptor agonist AR, ESR1, PGR, SRD5A1 Launched nortriptyline 0.0626308915679097 0.0355264887683965 0.115927426236631 0.372140570603971 tricyclic antidepressant ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR1A, HTR2A, HTR2C, HTR6, KCNJ10, PGRMC1, SIGMAR1, SLC6A2, SLC6A4 Launched noscapine 0.0645210943808509 0.0757540539907785 0.402147698531403 0.738912809105585 bradykinin receptor antagonist, tubulin polymerization inhibitor SIGMAR1 Launched npc-15199 0.072650622644337 0.034321455945396 0.0671620047162117 0.279841686317549 ICAM1 antagonist PPARG Phase 2 nvp-bez235 0.0898617911236032 0.042759220198941 0.039660767156367 0.212468395480538 mTOR inhibitor, PI3K inhibitor ATR, MTOR, PIK3CA, PIK3CD, PIK3CG Phase 3 nvp-bgj398 0.037405797198362 0.0420871323231098 0.376120178871579 0.71333137372196 FGFR inhibitor FGFR1, FGFR2, FGFR3, FGFR4, KDR Phase 3 obatoclax -0.0442284846270786 0.0540380871660791 0.424414482913541 0.75299343742725 BCL inhibitor BCL2 Phase 3 olaparib 0.0738376819927238 0.0419977535543769 0.0801476081335859 0.308178907081086 PARP inhibitor PARP1, PARP2 Launched olmesartan-medoxomil 0.192557503822706 0.0532710338880956 0.00683515967789647 0.0732338536917479 angiotensin receptor antagonist AGTR1 Launched omeprazole 0.0952581101981534 0.030134171032539 0.0133721206018153 0.110178207591459 ATPase inhibitor ATP4A, CLCN2 Launched orantinib -0.0539036440817826 0.0489751814106195 0.286398018964165 0.621785172751148 FGFR inhibitor, PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor AURKA, AURKB, EGFR, FGFR1, FGFR2, KDR, PDGFRA, PDGFRB Phase 3 ornidazole 0.145528966142149 0.0531102793474424 0.0254441962855293 0.161919560707621 antiprotozoal agent Launched orphenadrine 0.038126020300264 0.0766956335008341 0.632484982693897 0.896431567177881 acetylcholine receptor antagonist Launched osi-027 0.0863946373141618 0.0628707250032041 0.1872385550821 0.497077978862734 mTOR inhibitor MTOR Phase 1 osi-930 -0.0301538904635874 0.0280967973408404 0.285589311835773 0.62166538856072 KIT inhibitor, VEGFR inhibitor FLT1, KDR, KIT Phase 1 osimertinib -0.0108421108204418 0.0172086157926507 0.530134914683308 0.819028660325335 EGFR inhibitor EGFR Launched ouabain 0.162057334739194 0.0768750489187798 0.0422570212338579 0.220169967994813 ATPase inhibitor ATP1A1 Launched oxantel -0.0612217049953181 0.129080125495805 0.647967313960464 0.899954602722867 anthelmintic agent Launched oxaprozin -0.0860038168159177 0.070227506945267 0.255543534896102 0.58807686709277 cyclooxygenase inhibitor PTGS1, PTGS2 Launched oxfendazole 0.0211314900053667 0.124908928204164 0.869858252514995 0.954103537306562 anthelmintic agent Launched oxibendazole 0.0686797529887563 0.0621656231596318 0.301368652056849 0.634258004966583 tubulin polymerization inhibitor TUBB, TUBB4B Launched oxybenzone -0.0276744232627227 0.069139570596819 0.69943424515587 0.911584916672343 lipase inhibitor LIPE Launched oxybuprocaine 0.20714183957131 0.0675061635992618 0.0153831611054322 0.119727433131902 local anesthetic SCN10A Launched oxymetazoline -0.149322694664963 0.073447370465135 0.0764935678873558 0.305970449623841 adrenergic receptor agonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, HTR1B, HTR1D, HTR2C Launched ozagrel -0.146347728577538 0.077876721415924 0.0970213962934648 0.346504986762374 thromboxane synthase inhibitor TBXAS1 Launched paclitaxel 0.11461693009352 0.0632404327527075 0.0876239940094806 0.325629707467664 tubulin polymerization inhibitor BCL2, MAP2, MAP4, MAPT, NR1I2, TLR4, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 Launched palbociclib -0.00552068495396931 0.0146547406689895 0.708194864500992 0.916925879326847 CDK inhibitor CDK4, CDK6 Launched palmitoylethanolamide -0.100271191618897 0.154153937903998 0.533625186675968 0.82200716033505 cannabinoid receptor agonist CNR2, GPR119, GPR55 Launched panobinostat 0.117160086557534 0.0629517992433479 0.0801135468408442 0.308178907081086 HDAC inhibitor HDAC1, HDAC2, HDAC3, HDAC4, HDAC6, HDAC7, HDAC8, HDAC9 Launched pantoprazole 0.0933287744771566 0.184262721903519 0.626167907673747 0.895300734542186 ATPase inhibitor ATP4A Launched papaverine -0.101679950286959 0.0753811856898434 0.214311821812356 0.540936398676843 phosphodiesterase inhibitor PDE10A, PDE4B, PDE5A Launched parachlorophenol 0.01676198762205 0.0729119395595631 0.823943650364669 0.946731910237955 antiinfective drug Launched pargyline -0.0602097045517798 0.136774162855007 0.671434557665778 0.910739845909459 monoamine oxidase inhibitor MAOA, MAOB Launched paroxetine 0.221302388638634 0.0294606844222856 6.8509027520853e-05 0.00618738915867171 selective serotonin reuptake inhibitor (SSRI) CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HTR2A, SLC6A2, SLC6A4 Launched parthenolide 0.0335404544902811 0.114895325733224 0.772663024462547 0.932391101354502 NFkB pathway inhibitor Phase 1 pazopanib -0.0463182732179534 0.0321788698723007 0.152093371155821 0.432679417943284 KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, VEGFR inhibitor CSF1R, FGF1, FGFR1, FGFR3, FLT1, FLT4, ITK, KDR, KIT, PDGFRA, PDGFRB, SH2B3 Launched pca-4248 -0.118066938282075 0.107977813909267 0.30603029123573 0.637563106741104 platelet activating factor receptor antagonist PTAFR Phase 1 pci-24781 0.15057243424761 0.0471034939848296 0.0126763971194466 0.110178207591459 HDAC inhibitor HDAC1, HDAC2, HDAC3, HDAC6 Phase 3 pco-400 -0.00993125121652099 0.0527610361890729 0.855382771877152 0.949785715745155 potassium channel activator KCNJ8 Phase 1 pd-0325901 0.0505589417776496 0.0479832823363525 0.292660002727462 0.625503891839783 MEK inhibitor MAP2K1 Phase 2 pd-123319 0.0296944072395938 0.0787331681065202 0.710727072999301 0.916925879326847 angiotensin antagonist AGTR2 Phase 1 pd-184352 0.151713161827399 0.122450217783568 0.223598297296047 0.549574790413354 MEK inhibitor MAP2K1, MAP3K1, MAP3K2 Phase 2 penfluridol 0.1616264814927 0.0811079180256475 0.0814275639779004 0.309574840008147 T-type calcium channel blocker CACNA1G Launched pentoxifylline 0.0431978944197846 0.147601991728858 0.777225607501913 0.932391101354502 phosphodiesterase inhibitor ADORA1, ADORA2A, ADORA2B, ADRA2B, NT5E, PDE10A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, TNF Launched perindopril -0.0954396944300018 0.0749755749270499 0.238782009896266 0.567709389522823 angiotensin converting enzyme inhibitor ACE Launched perphenazine 0.111531206665073 0.0792999033714179 0.19722666246868 0.513287055320697 dopamine receptor antagonist CALM1, DRD1, DRD2, HRH1, HTR2A, HTR2C, HTR6, HTR7 Launched pf-03758309 0.131504657145114 0.0675147821314899 0.0543013541897671 0.247224671988414 p21 activated kinase inhibitor PAK4 Phase 1 pf-04217903 -0.031808704865981 0.0366117473926819 0.386894881315575 0.722302117829717 c-Met inhibitor MET Phase 1 pf-562271 -0.00322584823869744 0.149752762998603 0.983341558320225 0.989492436074094 focal adhesion kinase inhibitor PTK2, PTK2B Phase 1 pha-793887 -0.0068862484795584 0.0427362629185588 0.873887581699732 0.954103537306562 CDK inhibitor CDK1, CDK2, CDK4, CDK5, CDK7, CDK9 Phase 1 phenazone 0.0738623281747716 0.0563752188184574 0.226496794115221 0.552675556629253 cyclooxygenase inhibitor PTGS1, PTGS2 Launched phenazopyridine -0.0618249508460325 0.121375143521028 0.624242103876853 0.894096763365284 local anesthetic SCN1A Launched pheniramine -0.0516255359645697 0.133110134099619 0.708249574870018 0.916925879326847 histamine receptor antagonist HRH1 Launched phenoxybenzamine 0.0854207072442726 0.0301723321286213 0.0221129456503491 0.153304034970908 adrenergic receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C Launched phentolamine -0.0075258846719851 0.111807019606955 0.947985695188188 0.984184670138276 adrenergic receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C Launched phenylbutyrate -0.0752696309576289 0.0758681751386239 0.327953236586779 0.653530000444668 HDAC inhibitor HDAC1 Launched physostigmine 0.00108100443873024 0.0702053299279879 0.988091936141716 0.991778679666411 acetylcholinesterase inhibitor, cholinesterase inhibitor ACHE, BCHE Launched picotamide 0.183181556789421 0.0473014725751962 0.00472367848110819 0.057309334513445 thromboxane receptor antagonist, thromboxane synthase inhibitor TBXA2R Launched pimozide 0.0670201867876313 0.0392866231702034 0.0968818614578831 0.346504986762374 dopamine receptor antagonist CACNA1I, CALM1, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HTR1A, HTR2A, KCNA10, KCNH2 Launched pinacidil -0.0985817662568272 0.017316145798341 5.45389604553153e-06 0.00189069584777282 ATP channel activator, potassium channel activator ABCC8, ABCC9 Launched pindolol 0.0212728150323202 0.0865666403774444 0.812071235602518 0.943603900524053 adrenergic receptor antagonist ADRB1, ADRB2, HTR1A, HTR2A, HTR2B Launched pinocembrin 0.08941586613908 0.0212635159878191 0.000594998709697601 0.0181805161296489 cytochrome P450 inhibitor CYP1B1 Phase 2 pioglitazone -0.00353520122720194 0.071943237369919 0.961031100754395 0.986636188276503 insulin sensitizer, PPAR receptor agonist PPARG, TRPM3 Launched pipamperone 0.125642376320295 0.0300251169112008 0.00306038859684356 0.0459058289526534 dopamine receptor antagonist DRD2, HRH1, HTR1A, HTR1B, HTR1D, HTR2A Launched piperacetazine -0.127976577339621 0.0800891419328645 0.148726465573789 0.428465383714786 dopamine receptor antagonist Launched piperidolate -0.0763940220468066 0.066741312543324 0.268223569140179 0.601316425382195 acetylcholine receptor antagonist CHRM1 Launched piperine 0.0597851616892385 0.0748218660951383 0.43529337230536 0.760764401322752 monoamine oxidase inhibitor MAOA, MAOB, TRPV1 Phase 1 pirarubicin 0.145811482074985 0.0670258877571304 0.0439950492469484 0.22544046974368 topoisomerase inhibitor TOP2A Launched pirenzepine -0.0118807265188482 0.140632608600206 0.934750177320915 0.984184670138276 acetylcholine receptor antagonist CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 Launched piretanide 0.0191153349393819 0.0887079824273602 0.831952499378488 0.947492917316845 glucocorticoid receptor agonist SLC12A1, SLC12A2 Launched pirfenidone 0.000671693002101501 0.066062397309544 0.992005972881182 0.992005972881182 TGF beta receptor inhibitor FURIN, TNF Launched piroxicam -0.0992716507753573 0.11580132228963 0.416242400375391 0.748148105249886 cyclooxygenase inhibitor PTGS1, PTGS2 Launched pivmecillinam 0.0748665486337129 0.0434490563958584 0.103011538302584 0.357077811342991 bacterial cell wall synthesis inhibitor Launched pizotifen 0.114756716001911 0.0446274289685359 0.0330534909319713 0.18951184274107 serotonin receptor antagonist HTR1A, HTR2A, HTR2C Launched pk-11195 0.138051979417124 0.0840277835261563 0.139021268357823 0.411892603932091 benzodiazepine receptor antagonist TSPO Phase 1 plinabulin -0.0901062205888825 0.0621864835787512 0.165542093536883 0.453728329461556 tubulin polymerization inhibitor Phase 3 pnu-22394 -0.0491688680053837 0.0512133435448615 0.350472553105659 0.680329073675691 serotonin receptor agonist HTR2A, HTR2B, HTR2C, MAOA, MAOB Phase 2 podophyllotoxin 0.209395039106071 0.0531552667983157 0.00430006571249544 0.053750821406193 microtubule inhibitor, tubulin polymerization inhibitor IGF1R, TOP2A, TUBA4A, TUBB Launched ponatinib 0.0813473730976152 0.0703073566561991 0.249838613996323 0.582251007194821 Bcr-Abl kinase inhibitor, FLT3 inhibitor, PDGFR tyrosine kinase receptor inhibitor ABL1, BCR, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, KDR, KIT, LCK, LYN, PDGFRA, RET, SRC, TEK Launched potassium-canrenoate -0.148459065744222 0.0406430306551724 0.00646855080887818 0.0705823540136699 mineralocorticoid receptor antagonist NR3C2 Launched pravastatin 0.0291923652372435 0.0236437113730581 0.220564709302708 0.548090015586548 HMGCR inhibitor HMGCR, SLCO1B1 Launched praziquantel 0.0619902911996125 0.0301832142788562 0.0740697968355464 0.298085767752809 anthelmintic agent Launched prazosin -0.00879337449188206 0.0302508521855501 0.778687841010002 0.932391101354502 adrenergic receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, KCNH2, KCNH6, KCNH7 Launched prednicarbate 0.143490278743566 0.0879782240952621 0.141541584693121 0.41555803335169 phospholipase activator PLA2G1B Launched prednisolone 0.0360950511584532 0.0648740822937947 0.593164219173847 0.867660426983021 glucocorticoid receptor agonist NR3C1, NR3C2, SERPINA6 Launched prednisolone-acetate -0.0436131473854328 0.125626438599261 0.737423158034338 0.920830898520516 glucocorticoid receptor agonist NR3C1 Launched prednisone 0.000667806921997547 0.0481553689712166 0.989275091150684 0.991778679666411 glucocorticoid receptor agonist HSD11B1, NR3C1 Launched pregnenolone 0.0208724712264584 0.0520197499655408 0.689116046590522 0.910739845909459 glutamate receptor modulator SULT2B1 Launched primaquine 0.00940654213292426 0.0640853044833612 0.886935969605135 0.957572900671529 antimalarial agent, DNA inhibitor Launched primidone 0.0576710494030413 0.0848887187368551 0.516072943154502 0.810624673563108 GABA receptor antagonist CHRNA4, CHRNA7, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA2, GRIK2, SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A Launched probenecid -0.0116713544851833 0.151519087828154 0.940492166335649 0.984184670138276 uricosuric blocker PANX1, SLC22A11, SLC22A6, SLC22A8, SLCO1C1 Launched probucol -0.0579776852833719 0.140768339833787 0.691251958066147 0.910739845909459 atherogenesis inhibitor ABCA1, ABCB11, CES1 Launched procainamide -0.0995346210955484 0.134210065686262 0.479513087055628 0.788090466912988 sodium channel blocker DNMT1, SCN5A Launched procarbazine -0.064501891592961 0.0707735976181019 0.388729867050175 0.722302117829717 monoamine oxidase inhibitor Launched procaterol 0.0909084923640806 0.0389902054548266 0.0322822140417449 0.18951184274107 adrenergic receptor agonist ADRB2 Launched prochlorperazine 0.0590809373445494 0.12341744151377 0.644956193345325 0.899954602722867 dopamine receptor antagonist DRD1, DRD2, DRD3, DRD4 Launched progesterone 0.054370731829014 0.0661046536193297 0.41448057398843 0.748148105249886 progesterone receptor agonist CATSPER1, CATSPER2, CATSPER3, CATSPER4, CYP17A1, ESR1, NR3C2, OPRK1, PGR, TRPC5 Launched proguanil 0.107980801389213 0.0603592812626982 0.111415019083879 0.369146147567069 dihydrofolate reductase inhibitor DHFR Launched promazine 0.159061044990546 0.0857592362500307 0.100741085889368 0.353732597563922 dopamine receptor antagonist ADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, HRH1, HTR2A, HTR2C Launched propafenone -0.186780588715366 0.0808928784099975 0.0497677375764604 0.240107505851344 antiarrhythmic ADRB1, ADRB2, KCNA5, KCNH2 Launched propofol -0.100282630300731 0.0301349094416889 0.0104186076733946 0.096576981242141 benzodiazepine receptor agonist FAAH, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, SCN2A, SCN4A Launched propoxycaine -0.0118030679591486 0.0605465397451714 0.847749105747501 0.947492917316845 local anesthetic Launched protriptyline 0.0771741567188279 0.0848634436233145 0.389718160006249 0.722511195517203 tricyclic antidepressant SLC6A2, SLC6A4 Launched proxymetacaine -0.0165438963176994 0.100785912877071 0.871549780029727 0.954103537306562 sodium channel blocker SCN10A, SCN5A Launched pterostilbene -0.00931350796191579 0.028671722063504 0.747241509175144 0.922865636331577 cyclooxygenase inhibitor, PPAR receptor agonist PTGS2 Phase 2/Phase 3 pu-h71 0.0963036155381433 0.0839424867765593 0.267165737805642 0.600576931034481 HSP inhibitor HSP90AA1 Phase 1 pyrimethamine -0.07806811229178 0.0561090719800198 0.201584633884151 0.518091348767678 dihydrofolate reductase inhibitor DHFR, SLC47A1 Launched pyroxamide 0.045616793218906 0.0496278371019706 0.370861578307944 0.704978806691368 HDAC inhibitor HDAC1 Phase 1 quercetin 0.0326233709341886 0.05128927054608 0.528028217343953 0.818840750580378 polar auxin transport inhibitor ATP5A1, ATP5B, ATP5C1, HCK, HIBCH, PIK3CG, PIM1, STK17B, UGT3A1 Launched quetiapine 0.18372472834186 0.0865881624081665 0.0666358737774007 0.279058862265764 dopamine receptor antagonist, serotonin receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2C, HTR3A, HTR6, HTR7, SLC6A2 Launched quinapril 0.202456908088621 0.0674932822354133 0.00806053525410652 0.082145296382919 angiotensin converting enzyme inhibitor ACE Launched quinelorane 0.0864062720108819 0.0364517243634835 0.0452160385724848 0.22759645341488 dopamine receptor agonist DRD2, DRD3 Phase 3 quinidine -0.0730330793815737 0.0636428840771651 0.255565253412143 0.58807686709277 sodium channel blocker KCNA5, KCNA7, KCNH1, KCNH2, KCNH5, KCNK1, KCNK6, SCN5A, SLC29A4 Launched quinpirol-(-) -0.147430892252347 0.0605124370209001 0.0407946300071788 0.214366686343455 dopamine receptor agonist DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2A, HTR2B, HTR2C Phase 2 quizartinib 0.0547911100991737 0.033538717690822 0.104844964887908 0.35890911216815 FLT3 inhibitor CSF1R, FLT3, KIT, PDGFRA, PDGFRB, RET Phase 3 racecadotril 0.150952898761247 0.0655960522660152 0.0503724665333811 0.240215519595603 enkephalinase inhibitor MME Launched raclopride 0.0406827477351962 0.0761343074241934 0.600015214926095 0.873550203960804 dopamine receptor antagonist DRD2, DRD3, HTR1A Launched raloxifene -0.0474361358206803 0.125386354723787 0.715034722737324 0.916925879326847 estrogen receptor antagonist, selective estrogen receptor modulator (SERM) ESR1, ESR2 Launched raltegravir 0.023845927523602 0.0424914728330618 0.581988569084403 0.863025227063129 HIV integrase inhibitor Launched raltitrexed 0.015987277241708 0.0820549157272386 0.847830605209087 0.947492917316845 thymidylate synthase inhibitor FPGS, TYMS Launched ranitidine -0.00789852754815927 0.0171805781411897 0.649527100305305 0.90060480294433 histamine receptor antagonist HRH2 Launched ranolazine -0.0258947842946082 0.0643247299325696 0.697812001911152 0.910909654393513 sodium channel blocker SCN10A, SCN9A Launched rebastinib 0.138939840364302 0.0489803686386554 0.00545397927622912 0.0642790414698432 Bcr-Abl kinase inhibitor, TIE tyrosine kinase inhibitor, VEGFR inhibitor ABL1, BCR, FGR, FLT3, HCK, LYN, SRC Phase 1/Phase 2 reboxetine 0.0304504122086745 0.0517462035435591 0.559234418919082 0.842466183255701 adrenergic receptor antagonist SLC6A2 Launched regorafenib -0.0455826027391699 0.0204568763110229 0.0279570308687225 0.170736715333847 FGFR inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RAF inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, MAPK11, NTRK1, PDGFRA, PDGFRB, RAF1, RET, TEK Launched relcovaptan 0.00406622269955049 0.0885612642843591 0.963913657879832 0.986636188276503 vasopressin receptor antagonist AVPR1A, AVPR1B, AVPR2, OXTR Phase 2 remacemide 0.133091149821196 0.0961980364970123 0.203885908144936 0.522378491365131 glutamate receptor antagonist GRIN1 Phase 3 reserpine 0.034723451447802 0.0302385264205829 0.284012412646076 0.621512574092872 vesicular monoamine transporter inhibitor SLC18A1, SLC18A2 Launched resorcinol 0.0533499956673434 0.163169556435365 0.752088543295162 0.927258191368481 phosphodiesterase inhibitor CA12, CA14, CA2, PTGS1 Launched resveratrol -0.056622888635512 0.0173898018693565 0.00139281272585959 0.0285207934353486 cytochrome P450 inhibitor, SIRT activator CSNK2A1, NQO2, PTGS1, PTGS2 Launched retinol 0.0368628738379668 0.0378959759655438 0.332877198065963 0.660153097126008 retinoid receptor ligand ALDH1A1, ALDH1A2, ALDH1A3, DHRS3, DHRS4, LRAT, NR2C2, RBP1, RBP3, RDH11, RDH12, RDH13, RDH14, RDH5, RDH8, RETSAT, RHO, RLBP1, RXRA, RXRB, RXRG Launched retinyl-acetate -0.00846834756557314 0.032586207105413 0.795966926453426 0.940886055567534 Launched rev-5901 0.15038195851038 0.0750847868810807 0.0801641569292535 0.308178907081086 leukotriene receptor antagonist, lipoxygenase inhibitor ALOX5 Phase 2 riboflavin 0.0892121890730282 0.0341215303684899 0.0181261912250113 0.13003571965769 vitamin B BLVRB, RFK Launched rifabutin 0.113500067000011 0.0658163003921394 0.102751481783273 0.357077811342991 protein synthesis inhibitor Launched rigosertib 0.122839133785618 0.0388435581245118 0.00203639873512406 0.0365223686190728 cell cycle inhibitor, PLK inhibitor PLK1 Phase 3 rilmenidine -0.0335485828893898 0.0333666148926771 0.32017608223866 0.650804793690333 adrenergic receptor agonist, imidazoline receptor agonist ADRA2A Launched riluzole 0.0247609242211271 0.033655660695125 0.463839598669553 0.777779814842238 glutamate inhibitor KCNK10, KCNK2, KCNK4, KCNN4, SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A, SLC7A11 Launched rimcazole -0.00661111997413606 0.0769973683979639 0.932579563306372 0.984184670138276 sigma receptor antagonist SIGMAR1 Phase 1 rimexolone 0.0665645829241516 0.0383600962872831 0.100785695803842 0.353732597563922 glucocorticoid receptor agonist NR3C1, SERPINA6 Launched risperidone 0.0666337125545818 0.0839870059542864 0.431813517178931 0.756361256205134 dopamine receptor antagonist, serotonin receptor antagonist ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, HRH1, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2C, HTR6, HTR7 Launched ritanserin -0.0150141109500968 0.0915035610012431 0.873736167177117 0.954103537306562 serotonin receptor antagonist ADRA1A, ADRA1B, ADRA1D, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 Phase 3 rivaroxaban -0.139714675854812 0.0411018951284869 0.00341348391663872 0.047730919173338 coagulation factor inhibitor F10 Launched rizatriptan -0.0622282139840628 0.072529789767789 0.41587312756714 0.748148105249886 serotonin receptor agonist HTR1A, HTR1B, HTR1D, HTR1E, HTR1F Launched rolipram -0.0344263663916137 0.051542656966842 0.507673291805179 0.803897247100331 phosphodiesterase inhibitor Phase 3 ropinirole -0.0228395040379154 0.103249635759239 0.830473167739854 0.947492917316845 dopamine receptor agonist ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C Launched roquinimex -0.0151637520081364 0.102065915979837 0.885571004389334 0.957572900671529 angiogenesis inhibitor, tumor necrosis factor production inhibitor Phase 3 roscovitine 0.248594340044646 0.0292681274612928 2.83063728344687e-05 0.00467055151768734 CDK inhibitor CDK2, CDK9 Phase 2 rosmarinic-acid -0.00823924694583213 0.0820624462922708 0.922495629435931 0.979483776428112 GABA transaminase inhibitor MCL1, TYR Launched rosuvastatin 0.142237890857721 0.053163130451968 0.0281215100706704 0.170736715333847 HMGCR inhibitor HMGCR Launched ru-24969 -0.0430004187033948 0.0422486077889048 0.314339451366292 0.646708347574042 serotonin receptor agonist HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, HTR6 Phase 1 rucaparib 0.0365349391095493 0.0258166718963992 0.159922963661869 0.445731233179196 PARP inhibitor PARP1, PARP2 Phase 3 rutin -0.00410123748559331 0.101725415013776 0.968310313874378 0.987551368132004 antioxidant, capillary stabilizing agent, nitric oxide scavenger AKR1C3 Launched ruxolitinib 0.0207172404299501 0.0566870929490362 0.71696261511956 0.916925879326847 JAK inhibitor JAK1, JAK2, JAK3, TYK2 Launched rwj-21757 -0.0249165374904143 0.0972665354968762 0.804285562793973 0.94111784575798 toll-like receptor agonist TLR7 Phase 2 safinamide 0.0183459961058413 0.0507293219221894 0.722073266735077 0.916925879326847 dopamine reuptake inhibitor, glutamate inhibitor, monoamine oxidase inhibitor MAOB Launched salicin -0.00647331865712026 0.0960795255957258 0.94706956954146 0.984184670138276 anti-inflammatory agent Phase 1 salmeterol -0.0325031822070535 0.072558586620182 0.666066190081604 0.909775839101529 adrenergic receptor agonist ADRB2 Launched salvinorin-a 0.072198386590288 0.158740496841116 0.661326716399022 0.906423903428226 opioid receptor agonist OPRD1, OPRK1, OPRM1 Phase 1 saquinavir 0.209336105668452 0.0436420193348582 0.00136132908305223 0.0285207934353486 HIV protease inhibitor CYP3A4 Launched sar-245409 -0.0076400753764749 0.0222943115807259 0.732502707097036 0.919653011114989 PI3K inhibitor MTOR, PIK3CG Phase 1/Phase 2 saracatinib 0.0558572558559929 0.0476967698184641 0.243789797265682 0.574647379269108 SRC inhibitor ABL1, LCK, SRC, YES1 Phase 2/Phase 3 sb-939 0.0612831315869475 0.110676597955564 0.580930165743522 0.863025227063129 HDAC inhibitor HDAC1, HDAC10, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC9 Phase 3 scopolamine -0.0479323965833947 0.0537916658248383 0.378973979282856 0.714033351072222 acetylcholine receptor antagonist CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, SI Launched sdz-nkt-343 -0.0365632162597375 0.0351285901760054 0.312527516314814 0.646203511177247 tachykinin antagonist TACR1 Phase 1 sdz-wag-994 0.0558018965125856 0.0507206898191914 0.303253835425598 0.63498582290893 adenosine receptor agonist ADORA1 Phase 2 selumetinib 0.119982281067904 0.0651913028676905 0.0771416406324351 0.305970449623841 MEK inhibitor MAP2K1 Phase 3 semaxanib 0.125778143055097 0.0599456293809051 0.0511373103483109 0.240802585589028 VEGFR inhibitor FGFR1, FLT1, KDR, KIT, PDGFRA, PDGFRB, RET Phase 3 serdemetan -0.0570652177016058 0.0358680086093701 0.114564746645586 0.37210990544334 MDM inhibitor MDM2 Phase 1 serotonin 0.0166331184430518 0.0238965566241718 0.487908768098867 0.795503426248153 growth factor receptor activator DRD1, DRD5, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, HTR7, SLC36A1 Launched sertaconazole 0.0557697979592514 0.128672787715418 0.676156843017533 0.910739845909459 sterol demethylase inhibitor Launched sertraline 0.211616304898057 0.0991590356663846 0.0653732604058516 0.27800484450942 selective serotonin reuptake inhibitor (SSRI) SLC6A3, SLC6A4 Launched sgi-1776 0.0107378489305929 0.0568230760361038 0.850507236786985 0.947492917316845 Pim kinase inhibitor FLT3, PIM1, PIM2, PIM3 Phase 1 sgx523 -0.0564477954558176 0.0191444633779683 0.00392131369319682 0.0513505364585298 hepatocyte growth factor receptor inhibitor MET Phase 1 sib-1553a 0.011708828838467 0.0418941332677035 0.78151681678641 0.933070005569882 acetylcholine receptor agonist CHRNB4 Phase 2 siguazodan 0.0557690321088284 0.135551113610846 0.69156272865691 0.910739845909459 phosphodiesterase inhibitor PDE3A Phase 1 sildenafil 0.074344304137711 0.0604450732105074 0.253656688636883 0.587828000352327 phosphodiesterase inhibitor PDE5A, PDE6G, PDE6H, SLCO1B1, SLCO1B3 Launched simvastatin -0.00477879362410311 0.0206029967535479 0.817654948093752 0.946731910237955 HMGCR inhibitor HMGCR, ITGB2 Launched sirolimus 0.151230397441071 0.0377826438487919 9.76187535738613e-05 0.00618738915867171 mTOR inhibitor FKBP1A, MTOR Launched sitagliptin 0.0951216906319966 0.0207625032656287 0.000265363573821385 0.00999793083644996 dipeptidyl peptidase inhibitor DPP4 Launched sns-314 0.111232959248205 0.086252441564114 0.214451975440035 0.540936398676843 Aurora kinase inhibitor AURKA, AURKB, AURKC Phase 1 somatostatin 0.055927950281748 0.0823513420278586 0.506192240601356 0.803897247100331 somatostatin receptor agonist OPRD1, OPRM1, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5 Launched sorafenib 0.0703096208673177 0.0411379791376437 0.0917972555289197 0.336589936939372 FLT3 inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RAF inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor BRAF, DDR2, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET Launched spiperone 0.0508049772837775 0.0452635040650824 0.266740151861853 0.600576931034481 dopamine receptor antagonist ADRA1A, ADRA1B, ADRA1D, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1D, HTR2A, HTR2B, HTR2C, HTR6, HTR7 Launched spironolactone 0.0256391099144529 0.0777566204897872 0.745628070542916 0.922253610491613 mineralocorticoid receptor antagonist AR, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CYP11B2, NR3C1, NR3C2, PGR, SHBG Launched sr-27897 -0.108612335265037 0.123480670342676 0.39134600437658 0.723902362355781 CCK receptor antagonist CCKAR Phase 2 sr-57227a 0.0645638658320824 0.0414447445284947 0.137694046687336 0.410737100201914 serotonin receptor agonist HTR3A Phase 2 sulconazole 0.0922118430787734 0.0741351034417361 0.248769936284954 0.581402825595147 sterol demethylase inhibitor Launched sulfafurazole 0.114258346152591 0.0775600007029834 0.178929476466601 0.479275383392681 bacterial antifolate Launched sulindac -0.0266905222349512 0.0105131468742235 0.0133175542103498 0.110178207591459 cyclooxygenase inhibitor AKR1B1 Launched sulmazole 0.0919532799481177 0.0301350838431288 0.0157881553140203 0.121367312788305 adenosine receptor antagonist Phase 1 sunitinib 0.0128196187551726 0.0310076647620919 0.68005207101225 0.910739845909459 FLT3 inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor CSF1R, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB, RET Launched suramin -0.008260500328784 0.0466029314534297 0.859814517891272 0.951489310127269 DNA synthesis inhibitor F2, FSHR, P2RY1, P2RY11, P2RY13, P2RY2, PLA2G2A, RYR1, RYR2, SIRT5 Launched tacedinaline 0.184358612636936 0.0469678449357319 0.000153578922113298 0.00741444023921543 HDAC inhibitor HDAC1 Phase 3 tacrolimus 0.116122170427881 0.0311991061931774 0.000961231663885537 0.0233240036089873 calcineurin inhibitor FKBP1A Launched tadalafil -0.00898493452135624 0.0301927271960012 0.773600477156108 0.932391101354502 phosphodiesterase inhibitor PDE11A, PDE5A Launched tak-715 -0.0110319319417504 0.0305742723509571 0.718840064721556 0.916925879326847 p38 MAPK inhibitor MAPK14 Phase 2 talipexole 0.0948067143251698 0.021291120702849 0.000349259208430493 0.0120057852897982 adrenergic receptor agonist, dopamine receptor agonist ADRA2A, DRD2, HTR3A Launched talniflumate 0.228771136711902 0.0498047875093716 0.00177077145552027 0.033974103507075 cyclooxygenase inhibitor CLCA1 Launched tamibarotene 0.0179565045918777 0.0575984166273609 0.759018861598626 0.929066113974579 retinoid receptor agonist RARA, RARB Launched tamoxifen 0.0749313338999668 0.0220821453684045 0.00103259978649567 0.0243398521102551 estrogen receptor antagonist, selective estrogen receptor modulator (SERM) EBP, ESR1, ESR2, GPER1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ Launched tandutinib -0.0388235056035934 0.0415724562704865 0.363443948071938 0.698930669369112 FLT3 inhibitor, KIT inhibitor, PDGFR tyrosine kinase receptor inhibitor CSF1R, FLT3, KIT, PDGFD, PDGFRB Phase 2 tanespimycin 0.153203343655189 0.0612763166978915 0.0142442716760541 0.112995424353314 HSP inhibitor HSP90AA1 Phase 3 teicoplanin -0.122975321282543 0.0505248400712444 0.0262556665950275 0.162864097299983 bacterial cell wall synthesis inhibitor Launched telenzepine 0.0157496732155402 0.0980711360196895 0.87430578691365 0.954103537306562 acetylcholine receptor antagonist CHRM1 Phase 3 telmisartan -0.0955201980176017 0.0462607110206713 0.0545392609719896 0.247224671988414 angiotensin receptor antagonist AGTR1, PPARG Launched temefos -0.0686380389618692 0.111358949698475 0.554781260513289 0.841656195506561 cholinesterase inhibitor Launched temozolomide 0.0977892197705053 0.0974586135215359 0.322558601208458 0.652286839792142 DNA alkylating agent MGMT Launched tenidap 0.0675841444795063 0.0558926885997024 0.243143748402153 0.574647379269108 cyclooxygenase inhibitor KCNJ4, PTGS1 Phase 3 teniposide 0.0769668796966528 0.112161903233958 0.511973155364712 0.807605837812404 topoisomerase inhibitor TOP2A, TOP2B Launched tenofovir 0.177284005674673 0.0501278717708739 0.00765739625242771 0.0809916911314469 HIV integrase inhibitor, nucleoside reverse transcriptase inhibitor Launched tenoxicam 0.0378594461904744 0.122211012851727 0.760487724647261 0.929484996791097 cyclooxygenase inhibitor PTGS1, PTGS2 Launched terconazole 0.0116625057724408 0.0204356975908943 0.575674585994963 0.858827366086518 sterol demethylase inhibitor Launched terguride -0.0680723048113347 0.158804949361598 0.679483741604568 0.910739845909459 dopamine receptor agonist, serotonin receptor antagonist ADRA1A, ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, DRD4, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C Launched tetrabenazine -0.0527266872267406 0.0338387912141682 0.1221452012771 0.380263362466443 vesicular monoamine transporter inhibitor SLC18A1, SLC18A2 Launched tetradecylthioacetic-acid -0.0223612248710424 0.019765658502131 0.263014845160899 0.596118811147642 lipid peroxidase inhibitor Phase 2 tetramisole 0.170557177771949 0.0707371994472721 0.0424327574680912 0.220169967994813 immunostimulant ALPPL2, CHRNA3 Launched thalidomide -0.0172558769181836 0.0608761177376079 0.778154586873496 0.932391101354502 tumor necrosis factor production inhibitor TNF Launched thiethylperazine 0.153120028695864 0.0240079077407464 6.87525762826479e-06 0.00189069584777282 dopamine receptor antagonist DRD1, DRD2, DRD4 Launched thiocolchicoside 0.12552181624347 0.069681558692587 0.109324928704768 0.366638480412332 GABA receptor antagonist GABRA1, GABRB2, GABRG2, GLRA1, GLRB Launched thioproperazine 0.0862286618236557 0.0791211849691321 0.307523602992867 0.638478240422859 dopamine receptor antagonist ADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A Launched thiorphan -0.043246945292923 0.051062801147064 0.421642295657849 0.75299343742725 membrane metalloendopeptidase inhibitor MME Phase 1 thiostrepton 0.223647968780016 0.0902400966161663 0.0382088669220872 0.206028203991647 FOXM1 inhibitor, protein synthesis inhibitor FOXM1 Launched thiotepa 0.0315329511384539 0.155742947386271 0.844605183183415 0.947492917316845 cytochrome P450 inhibitor CYP2B6, CYP3A4 Launched thiothixene -0.0872811687967805 0.0771363062077896 0.290612646310396 0.623248662635638 dopamine receptor antagonist DRD1, DRD2, HRH1, HTR2A Launched tiabendazole 0.192641647320021 0.0703497715743132 0.0255145974448373 0.161919560707621 angiogenesis inhibitor Launched ticlopidine 0.14522725756494 0.0417946301036549 0.00838362213895948 0.0827699938335376 purinergic receptor antagonist P2RY12 Launched timolol -0.0537281059102078 0.12310892269288 0.674065484842087 0.910739845909459 adrenergic receptor antagonist ADRB1, ADRB2 Launched tiotidine 0.167331116752775 0.0613431528830714 0.0259343738202814 0.162864097299983 histamine receptor antagonist HRH2 Phase 2 tivantinib 0.107946458810412 0.0310286086231656 0.000729278353324274 0.0200551547164175 tyrosine kinase inhibitor MET Phase 3 tivozanib 0.0673885412447694 0.0202708672849262 0.00121409321387301 0.0278229694845898 VEGFR inhibitor FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB Launched tnp-470 0.0864763606427418 0.0582081810157539 0.146327103086876 0.426571943627819 methionine aminopeptidase inhibitor METAP2 Phase 2 tofacitinib -0.042999905201379 0.0407031008334316 0.296538675611937 0.630526823143938 JAK inhibitor JAK1, JAK2, JAK3 Launched tolazamide -0.062770142834646 0.0346369643727443 0.0767781044259228 0.305970449623841 ATP channel blocker ABCC8, KCNJ1, KCNJ10, KCNJ11 Launched tolbutamide -0.00195492671708055 0.0302771881797959 0.950102511331671 0.98471679880481 ATP channel blocker ABCC8, KCNJ1, KCNJ11, KCNJ8 Launched tolmetin 0.0170581850464093 0.0573499261236763 0.773707682017376 0.932391101354502 cyclooxygenase inhibitor PTGS1, PTGS2 Launched toltrazuril 0.206921100573087 0.0516503528904782 0.00391581045612536 0.0513505364585298 antiprotozoal agent Launched tomelukast -0.0244594365569775 0.0519069430800848 0.640409782134104 0.897008608252353 leukotriene receptor antagonist CYSLTR1 Phase 3 topotecan 0.0856828017345146 0.0504514653511097 0.107673865884126 0.365996558325368 topoisomerase inhibitor TOP1, TOP1MT Launched toremifene 0.164061899606938 0.0852442098259358 0.0904698697318506 0.333203761289182 estrogen receptor antagonist, selective estrogen receptor modulator (SERM) ESR1 Launched tozasertib 0.106544988844275 0.0723109865166461 0.14957337031498 0.428465383714786 Aurora kinase inhibitor, Bcr-Abl kinase inhibitor, FLT3 inhibitor, JAK inhibitor AURKA, AURKB, AURKC, LCK Phase 2 tracazolate 0.0134826003520128 0.0536713454576649 0.807986471830055 0.94111784575798 GABA receptor modulator GABRA1 Phase 2 tranilast -0.0902901334512939 0.054778478221194 0.137908093037491 0.410737100201914 angiogenesis inhibitor HPGDS, HRH1 Launched tranylcypromine -0.0263075895840228 0.038262857848104 0.492626744639545 0.800033591196111 monoamine oxidase inhibitor KDM1A, MAOA, MAOB Launched trapidil 0.0817589225914838 0.0612813269085996 0.199750297242067 0.516500158594801 PDGFR tyrosine kinase receptor inhibitor PDGFRA Launched trazodone -0.0479486317247178 0.113295146736261 0.67744130045815 0.910739845909459 adrenergic receptor antagonist, serotonin receptor antagonist, serotonin reuptake inhibitor ADRA1A, ADRA2A, HRH1, HTR1A, HTR2A, HTR2B, HTR2C, SLC6A4 Launched treprostinil 0.149645905905848 0.0405802517860486 0.00182613971674248 0.0342401196889215 prostanoid receptor agonist P2RY12, PPARD, PTGIR Launched tretinoin -0.0161360870314574 0.0465785147354351 0.729701633151949 0.919653011114989 retinoid receptor agonist, retinoid receptor ligand ALDH1A1, ALDH1A2, GPRC5A, NR0B1, NR2C2, PPARD, RARA, RARB, RARG, RARRES1, RORB, RORC, RXRB, RXRG Launched triamcinolone 0.0385094338831094 0.147032612779707 0.800007639802032 0.940886055567534 glucocorticoid receptor agonist NR3C1 Launched triamterene 0.0230806275401127 0.0874259570346101 0.798451771205608 0.940886055567534 sodium channel blocker SCNN1A, SCNN1B, SCNN1D, SCNN1G Launched trichostatin-a 0.160396477775246 0.0780627900999576 0.0405795731955042 0.214366686343455 HDAC inhibitor HDAC1, HDAC10, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 Phase 1 triciribine 0.0294507276884023 0.0393913292035957 0.45865166980535 0.773798829426204 AKT inhibitor AKT1, AKT2, AKT3 Phase 1/Phase 2 triclosan 0.0650873601902376 0.0301977209092327 0.0632436616954508 0.274470254057028 antibacterial agent DNMT1 Launched trifluoperazine 0.0909559125383722 0.047410752083462 0.0632380457837391 0.274470254057028 dopamine receptor antagonist ADRA1A, CALM1, CALY, DRD2, DRD4, HRH1, HTR2A, HTR2C, S100A4, TNNC1 Launched triflupromazine 0.0801017146564214 0.082251986720105 0.343781822835442 0.672520521029605 dopamine receptor antagonist CHRM1, CHRM2, DRD1, DRD2, HTR2B Launched trifluridine 0.0217220475028288 0.0320855177489871 0.502853338257038 0.802425539771869 DNA directed DNA polymerase inhibitor, thymidylate synthase inhibitor TYMS Launched trimethobenzamide 0.0113129576770186 0.151871921824825 0.942449356289926 0.984184670138276 histamine receptor antagonist DRD2 Launched trimetozine -0.00382772639657979 0.164334624364971 0.98198763647659 0.989492436074094 sedative Launched trimipramine 0.0881283329353587 0.0378369462065286 0.0324386561366074 0.18951184274107 norepinephrine reputake inhibitor, tricyclic antidepressant SLC6A2, SLC6A3, SLC6A4 Launched trioxsalen -0.0218888361679666 0.0875101241218442 0.808790972899888 0.94111784575798 DNA synthesis inhibitor Launched tripelennamine -0.0780914839222292 0.144212139124789 0.602909665872012 0.875452476146448 histamine receptor antagonist HRH1 Launched tropisetron -0.0196045574893695 0.0407982086919816 0.636979626794686 0.896431567177881 serotonin receptor antagonist GLRA1, GLRA2, GLRB, HTR3A, HTR4 Launched ttnpb 0.0386811171741504 0.0337949228368835 0.25678115920143 0.588456823169944 retinoid receptor agonist RARA, RARB, RARG Phase 1 tubocurarine -0.0355631490042754 0.0518616721250329 0.498952204677666 0.800894314794982 acetylcholine receptor antagonist ACHE, CHRNA2, HTR3A, HTR3B, KCNN1, KCNN2, KCNN3, ZACN Launched ubenimex -0.052079014907705 0.16693421987081 0.763036809781493 0.929845447665778 leukotriene synthesis inhibitor LTA4H, RNPEP Launched valproic-acid 0.00127801793892533 0.0490861184265342 0.979301474466151 0.989492436074094 benzodiazepine receptor agonist, HDAC inhibitor ABAT, ACADSB, ALDH5A1, HDAC1, HDAC2, HDAC9, OGDH, SCN10A, SCN11A, SCN1A, SCN1B, SCN2A, SCN2B, SCN3A, SCN3B, SCN4A, SCN4B, SCN5A, SCN7A, SCN8A, SCN9A Launched valsartan 0.116067304374887 0.0694282437736604 0.133114232206464 0.400800151716543 angiotensin receptor antagonist AGTR1 Launched vandetanib 0.0514165294667545 0.0399031338318218 0.200339455454953 0.516500158594801 EGFR inhibitor, RET tyrosine kinase inhibitor, VEGFR inhibitor EGFR, EPHA1, EPHA10, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB2, ERBB3, ERBB4, FLT1, FLT4, KDR, PTK6, RET, SRC, TEK, VEGFA Launched vanoxerine 0.106827609101415 0.0280901771235067 0.000549718200673612 0.0174429813675281 dopamine reuptake inhibitor SLC6A3 Phase 3 vardenafil 0.101175832443766 0.12907960567123 0.45572074742437 0.773600034208035 phosphodiesterase inhibitor PDE5A, PDE6G, PDE6H Launched varenicline 0.0689737105395492 0.0367099884923307 0.0775182224885364 0.305992983507381 acetylcholine receptor agonist CHRNA3, CHRNA4, CHRNA6, CHRNA7 Launched ve-822 -0.0374221924346126 0.0806464056321343 0.646489484778224 0.899954602722867 ATR kinase inhibitor ATM, ATR, MTOR, PIK3CG Phase 2 vecuronium 0.142606456915837 0.0269310101468967 5.93626662767661e-05 0.00618738915867171 acetylcholine receptor antagonist CHRNA2 Launched veliparib 0.0177280027333232 0.0297500245528798 0.551869665714322 0.840023015155564 PARP inhibitor PARP1, PARP2 Phase 3 vemurafenib -0.0154722279044702 0.0687969052360626 0.823100503601068 0.946731910237955 RAF inhibitor BRAF, RAF1 Launched venlafaxine -0.0861965582338414 0.0664652442752082 0.230828526647406 0.554088571015178 adrenergic inhibitor, norepinephrine reuptake inhibitor, serotoninƒ__norepinephrine reuptake inhibitor (SNRI) SLC6A2, SLC6A4 Launched verapamil -0.0192581478527661 0.0221153498662763 0.38858730368669 0.722302117829717 calcium channel blocker CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1I, CACNA1S, CACNB1, CACNB2, CACNB3, CACNB4, CYP3A4, KCNA10, KCNA7, KCNH2, KCNJ11, NALCN, SCN5A, SLC29A4, SLC6A4 Launched verteporfin 0.0280615233169912 0.0786935701724598 0.723537875687003 0.916925879326847 photosensitizing agent Launched vicriviroc -0.0355079958549071 0.0596289336570657 0.559365703116811 0.842466183255701 CC chemokine receptor antagonist CCR5 Phase 3 vinblastine 0.122747637195609 0.031531960659339 0.000617931307746285 0.0182069046032388 microtubule inhibitor, tubulin polymerization inhibitor JUN, TUBA1A, TUBB, TUBD1, TUBE1, TUBG1 Launched vincristine 0.100064941999177 0.0548573594881325 0.0796526043919584 0.308178907081086 tubulin polymerization inhibitor TUBA4A, TUBB Launched vinorelbine 0.135187832685674 0.0481169241196038 0.00806517455395932 0.082145296382919 tubulin polymerization inhibitor TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 Launched vinpocetine -0.00779164326908691 0.118624219129243 0.948396136678702 0.984184670138276 phosphodiesterase inhibitor, sodium channel blocker PDE1A, PDE1C Launched voriconazole -0.0132108575455537 0.0254359699152411 0.610194107008662 0.880087654339416 cytochrome P450 inhibitor CYP2C19, CYP2C9, CYP3A4, CYP3A5, PTGS1 Launched vorinostat 0.111882511699835 0.061947565202144 0.0714279771125947 0.289023330607199 HDAC inhibitor HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5, HDAC6, HDAC8, HDAC9 Launched vx-222 -0.0125549540962537 0.0865490310681059 0.886368112219906 0.957572900671529 HCV inhibitor Phase 2 vx-702 -0.0643281010297204 0.0258629748256402 0.023553301356434 0.157451122234862 p38 MAPK inhibitor IL1B, IL6, MAPK11, MAPK12, MAPK14, TNF Phase 2 vx-745 -0.0301253858332458 0.02555402823626 0.240681146255201 0.570580303622244 p38 MAPK inhibitor MAPK11, MAPK12, MAPK14 Phase 2 warfarin -0.0815583534239153 0.063195536691824 0.214129571455447 0.540936398676843 vitamin K antagonist VKORC1 Launched way-100635 0.0327397760183468 0.0301652858468579 0.285187708288354 0.62166538856072 serotonin receptor antagonist HTR1A Phase 1 xaliproden 0.034814041023109 0.0724967826548496 0.637195494943955 0.896431567177881 serotonin receptor agonist HTR1A Phase 3 xylazine -0.102136194068283 0.127335285681575 0.445663208468335 0.766302744708207 adrenergic receptor agonist ADRA2A, ADRA2B, ADRA2C Launched y-26763 0.0953668393357407 0.0545255585500103 0.118407377617001 0.375715717438561 potassium channel activator KCNJ8 Phase 1 y-27152 0.101895424024436 0.0924646066611785 0.302510498431742 0.63498582290893 potassium channel activator KCNJ8 Phase 1 ym-155 0.139830309898569 0.0924067605699809 0.148596481749751 0.428465383714786 survivin inhibitor BIRC5 Phase 2 ym-976 0.0463661804530029 0.0485897957568264 0.367903645500975 0.702593767449779 phosphodiesterase inhibitor PDE4A Phase 1 yohimbine 0.0519102201596234 0.0638711301522936 0.42375058584396 0.75299343742725 adrenergic receptor antagonist ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KCNJ1, KCNJ10, KCNJ11, KCNJ12, KCNJ14, KCNJ15, KCNJ8 Launched zacopride 0.00854355119685393 0.0390191879523957 0.827954860808109 0.947382469024535 serotonin receptor antagonist HTR3A, HTR3B, HTR4, HTR5A Phase 2 zaldaride -0.0650738111404466 0.148677642665615 0.673191598761491 0.910739845909459 calmodulin antagonist CALM1 Phase 3 zaprinast 0.0293141332841288 0.066137427802628 0.669340264626489 0.910739845909459 phosphodiesterase inhibitor GPR35, PDE1A, PDE4D, PDE5A, PDE9A Phase 2 zardaverine 0.1082497147906 0.0433276259450201 0.023023098418886 0.156975671037859 phosphodiesterase inhibitor PDE4D Phase 2 zatebradine -0.0192597270636524 0.0553795256696 0.732276523996387 0.919653011114989 HCN channel blocker HCN1, HCN2, HCN3, HCN4 Phase 3 zd-2079 0.0826747798373931 0.0353065233626273 0.0472952640718572 0.23087924768806 adrenergic receptor agonist ADRB3 Phase 2 zd-7114 -0.0092765373119985 0.120749679240324 0.94064973051518 0.984184670138276 adrenergic receptor agonist ADRB3 Phase 1 zd-7288 0.189101602745406 0.0371011772444827 0.000933398537855953 0.0233240036089873 HCN channel blocker HCN1, HCN2, HCN3, HCN4 Phase 2 zibotentan 0.0298767643962821 0.0822514895182002 0.72090538673831 0.916925879326847 endothelin receptor antagonist EDNRA Phase 3 ziprasidone -0.0800673862566055 0.086463168916122 0.367391310458442 0.702593767449779 dopamine receptor antagonist, serotonin receptor antagonist ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, HTR7, SLC6A4 Launched zk-93423 0.00365978815788122 0.0457125366760749 0.938155351923379 0.984184670138276 benzodiazepine receptor agonist GABRA1, GABRA2, GABRA3, GABRA5, GABRB2, GABRG2 Phase 3 zk-93426 -0.0416464446670193 0.110392866060231 0.71579402788497 0.916925879326847 benzodiazepine receptor antagonist GABRA1, GABRA2, GABRA3, GABRA5 Phase 1 zolmitriptan -0.027918463654854 0.137449672664881 0.844114097228151 0.947492917316845 serotonin receptor agonist HTR1A, HTR1B, HTR1D, HTR1E, HTR1F Launched zonisamide -0.039460961683217 0.0246861759567694 0.114371916295373 0.37210990544334 sodium channel blocker, T-type calcium channel blocker CA1, CA10, CA11, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CACNA1G, CACNA1H, CACNA1I, MAOA, MAOB, SCN10A, SCN11A, SCN1A, SCN1B, SCN2A, SCN2B, SCN3A, SCN3B, SCN4A, SCN4B, SCN5A, SCN7A, SCN8A, SCN9A Launched zosuquidar -0.00724729703957993 0.0724977006960618 0.921540837057493 0.979483776428112 P glycoprotein inhibitor ABCB1, ABCB4 Phase 3 zoxazolamine -0.0929202484976634 0.0300552468311772 0.0148524240496485 0.116697617532952 myorelaxant Phase 2 zstk-474 0.0821290152745953 0.0456001068762635 0.080313290936283 0.308178907081086 PI3K inhibitor PIK3CB, PIK3CD, PIK3CG Phase 1/Phase 2 zuclopenthixol -0.026018648511606 0.062474928763877 0.688018616403705 0.910739845909459 dopamine receptor antagonist ADRA1A, ADRA2A, DRD1, DRD2, DRD5, HRH1, HTR2A Launched