Category ID Description GeneRatio BgRatio pvalue padj geneID Count KEGG mmu04080 Neuroactive ligand-receptor interaction 89/951 193/4976 2.48979242516876e-18 4.87999315333077e-16 Adra1b/Gabrb1/Cysltr1/Grik1/Agtr1a/Grik3/Grm3/Gabrr1/Adra1a/Htr7/P2rx1/Chrna7/Gpr156/Tacr3/Trpv1/Grm1/Chrna6/Hcrtr2/Gabrg2/Chrm5/Lepr/Gabrb2/Mtnr1b/Gabrb3/Gabra3/Adra1d/Ednra/Grid1/S1pr3/Vipr2/Tacr1/Oxtr/Agtr2/Glp1r/Chrm2/Grm7/Ptafr/Hrh2/Cysltr2/Chrm1/Avpr1a/Gria2/Gzma/C3ar1/Tbxa2r/Nmbr/Hrh1/Htr6/S1pr1/Htr2a/Ptger3/Thrb/Trhr/Nmur2/Grm8/Mchr1/Gipr/Npy2r/Ednrb/Aplnr/Npbwr1/C5ar1/Calcrl/Gabrr2/Chrna1/Gpr50/Crhr2/Grm5/Ptgfr/Chrm4/Chrna10/P2ry10/Gabre/Tshr/Chrnb3/Grin2a/Grik2/Cckbr/Rxfp2/Npy1r/Npffr1/Galr1/Lpar4/Gria3/Grin3a/Lep/Adra2c/Gabrd/Grm4 89 KEGG mmu04514 Cell adhesion molecules (CAMs) 63/951 122/4976 3.11716636663984e-16 3.05482303930704e-14 Cd226/Nlgn1/Cdh2/H2-Q7/Cd4/H2-Q8/H2-Q6/Cldn11/Itgb8/Cadm3/Cd2/Itga4/Ptprc/H2-Ab1/H2-Aa/Cldn5/Mag/Cd34/Selp/Cntnap2/Icam2/Ptprm/Mpz/Vcam1/Pvrl3/Ncam1/Cldn19/Sele/Vcan/Pecam1/Sdc3/Negr1/Cdh5/H2-Eb1/Cdh15/Cd28/Cd40/Itgb2/H2-T24/Cntn1/H2-Q2/Cd8b1/Siglec1/Esam/Pdcd1/Itga8/Nfasc/Nlgn3/Icam1/Itga9/Cd8a/Jam3/H2-Oa/Cdh3/Cldn8/Cldn10/Cldn20/Jam2/Nrxn2/Itgb2l/Cd86/H2-Q10/H2-DMb2 63 KEGG mmu04020 Calcium signaling pathway 71/951 163/4976 2.92282106607959e-13 1.90957642983866e-11 Adcy8/Adra1b/Cysltr1/Agtr1a/Adra1a/Htr7/P2rx1/Chrna7/Tacr3/Grm1/Chrm5/Pde1b/Pde1a/Nos3/Adra1d/Ednra/Cd38/Tacr1/Pde1c/Oxtr/Atp2b3/Chrm2/Ptafr/Hrh2/Cysltr2/Chrm1/Cacna1c/Avpr1a/Chp2/Ryr3/Plcb2/Tbxa2r/Hrh1/Htr6/Pdgfrb/Htr2a/Ptger3/Trhr/Cacna1b/Atp2a3/Adcy4/Nos2/Adcy1/Ednrb/Plcb1/Tnnc2/Itpka/Mylk2/Cacna1e/Calm1/Itpr1/Atp2b4/Cacna1s/Grm5/Ptgfr/Adcy7/Cacna1h/Prkcb/Grin2a/Atp2a1/Cckbr/Slc8a2/Bst1/Pln/Cacna1g/Mylk3/Camk2b/Slc8a3/Ryr1/Phkg1/Camk2a 71 KEGG mmu05150 Staphylococcus aureus infection 29/951 41/4976 7.38912989985329e-13 3.62067365092811e-11 C1s2/Fcgr1/Cfb/C4b/Hc/H2-Ab1/H2-Aa/Fcgr2b/Selp/Fcgr3/Ptafr/C1qb/C1ra/H2-Eb1/C3ar1/C1qa/C1s1/Itgb2/Cfh/Fcgr4/Masp1/C1qc/C2/Icam1/C5ar1/H2-Oa/Itgb2l/Masp2/H2-DMb2 29 KEGG mmu04060 Cytokine-cytokine receptor interaction 78/951 192/4976 1.61148908224409e-12 6.31703720239685e-11 Il12rb2/Il21r/Hgf/Ccr2/Ccl21a/Cxcl12/Il7/Il18rap/Tnfsf15/Flt4/Csf2rb2/Tnfrsf8/Cxcl9/Ccr5/Lepr/Tpo/Flt3/Ccl11/Kdr/Cxcl13/Ccl3/Il2rb/Il7r/Il12b/Csf2rb/Pdgfd/Bmpr1b/Pf4/Ccr1/Fas/Csf3r/Csf3/Cxcr4/Cxcl5/Csf1r/Vegfc/Tgfb2/Epor/Inhba/Cd40/Ccl22/Ccl8/Amhr2/Pdgfrb/Cx3cr1/Xcr1/Tnfsf10/Ccl28/Tnfsf18/Il12rb1/Flt1/Fasl/Flt3l/Tnfsf8/Xcl1/Ccl7/Bmp2/Relt/Ccl4/Tnf/Cd27/Tnfrsf19/Cxcl2/Ccl12/Tgfb3/Il22ra2/Tnfrsf9/Il9r/Tnfsf13/Ccl6/Cxcl10/Il10ra/Il2rg/Cxcl14/Lep/Vegfa/Tgfbr2/Il11 78 KEGG mmu04610 Complement and coagulation cascades 28/951 52/4976 1.98478305450019e-08 6.48362464470062e-07 C1s2/Cfb/C4b/F5/Hc/Pros1/Vwf/Thbd/Cd55b/C1qb/Serping1/C1ra/C3ar1/Serpina1b/C1qa/C1s1/C4bp/Cfh/Serpina1e/Masp1/C1qc/F13a1/Proc/C2/C5ar1/F7/Serpine1/Masp2 28 KEGG mmu04976 Bile secretion 29/951 58/4976 9.67015741580116e-08 2.70764407642433e-06 Adcy8/Slc9a3/Slco1a4/Slco1a6/Abcb1a/Atp1a4/Abcg5/Slc4a5/Kcnn2/Atp1a3/Aqp9/Aqp4/Slc22a8/Nr1h4/Adcy5/Atp1b2/Adcy4/Adcy1/Abcg8/Aqp1/Slc4a4/Adcy7/Car2/Slc5a1/Nceh1/Abcb1b/Cftr/Atp1a2/Slc27a5 29 KEGG mmu04512 ECM-receptor interaction 37/951 84/4976 1.17647366940637e-07 2.88236049004561e-06 Col6a6/Tnr/Itgb8/Itga4/Spp1/Lama4/Col4a4/Vwf/Sv2b/Reln/Sv2c/Tnxb/Col3a1/Itgb3/Sdc3/Col5a3/Tnc/Thbs2/Lamc3/Sv2a/Itga8/Itga9/Lama2/Col2a1/Itga11/Col6a3/Col5a2/Itga1/Gp6/Col4a6/Cd36/Col4a1/Col6a2/Vtn/Col1a2/Col6a4/Col5a1 37 KEGG mmu04270 Vascular smooth muscle contraction 44/951 109/4976 1.70656255728178e-07 3.71651401363589e-06 Adcy8/Adra1b/Agtr1a/Kcnmb2/Adra1a/Gucy1a2/Acta2/Ramp3/Kcnmb1/Cyp4a30b/Mrvi1/Adra1d/Ednra/Myh11/Npr1/Pla2g2e/Myl9/Cyp4a32/Gucy1b3/Cacna1c/Gucy1a3/Pla2g2f/Avpr1a/Plcb2/Actg2/Cald1/Npr2/Pla2g4e/Adcy5/Adcy4/Adcy1/Plcb1/Ramp1/Mylk2/Calcrl/Calm1/Itpr1/Ppp1r14a/Cacna1s/Adcy7/Ramp2/Prkcb/Prkg1/Mylk3 44 KEGG mmu04974 Protein digestion and absorption 30/951 66/4976 8.24141552301205e-07 1.61531744251036e-05 Col6a6/Slc9a3/Kcnq1/Mme/Atp1a4/Col9a2/Eln/Col18a1/Col4a4/Atp1a3/Xpnpep2/Col3a1/Col14a1/Col5a3/Atp1b2/Slc6a19/Col15a1/Col2a1/Dpp4/Col6a3/Col5a2/Col4a6/Slc8a2/Col4a1/Slc8a3/Col6a2/Atp1a2/Col1a2/Col6a4/Col5a1 30 KEGG mmu05320 Autoimmune thyroid disease 19/951 33/4976 1.00303819487466e-06 1.78723169268576e-05 H2-Q7/H2-Q8/H2-Q6/Tpo/H2-Ab1/H2-Aa/Fas/Tg/H2-Eb1/Cd28/Cd40/H2-T24/H2-Q2/Fasl/H2-Oa/Tshr/Cd86/H2-Q10/H2-DMb2 19 KEGG mmu05330 Allograft rejection 18/951 31/4976 1.64321089419437e-06 2.68391112718413e-05 H2-Q7/H2-Q8/H2-Q6/H2-Ab1/H2-Aa/Il12b/Fas/H2-Eb1/Cd28/Cd40/H2-T24/H2-Q2/Fasl/H2-Oa/Tnf/Cd86/H2-Q10/H2-DMb2 18 KEGG mmu05332 Graft-versus-host disease 19/951 34/4976 1.86991705844019e-06 2.8192595650329e-05 H2-Q7/H2-Q8/H2-Q6/H2-Ab1/H2-Aa/Fas/H2-Eb1/Klrc1/Cd28/Klra3/H2-T24/H2-Q2/Fasl/H2-Oa/Tnf/Klrd1/Cd86/H2-Q10/H2-DMb2 19 KEGG mmu05414 Dilated cardiomyopathy 35/951 86/4976 2.52304287215243e-06 3.5322600210134e-05 Adcy8/Cacng4/Cacng7/Cacng5/Itgb8/Itga4/Igf1/Itgb3/Cacna1c/Tgfb2/Myl2/Myh7/Cacng8/Cacnb4/Adcy5/Adcy4/Tpm1/Adcy1/Itga8/Dmd/Itga9/Actc1/Lama2/Myh6/Itga11/Cacng1/Cacna2d4/Cacna1s/Adcy7/Tnf/Itga1/Tgfb3/Pln/Ttn/Sgcb 35 KEGG mmu04970 Salivary secretion 31/951 74/4976 4.61610401826148e-06 6.03170925052833e-05 Adcy8/Adra1b/Adra1a/Gucy1a2/Lyz1/Atp1a4/Adra1d/Dmbt1/Prkg2/Atp1a3/Cd38/Atp2b3/Gucy1b3/Gucy1a3/Ryr3/Plcb2/Adcy5/Atp1b2/Adcy4/Lyz2/Adcy1/Plcb1/Calm1/Itpr1/Atp2b4/Adcy7/Prkcb/Prkg1/Bst1/Trpv6/Atp1a2 31 KEGG mmu04971 Gastric acid secretion 29/951 68/4976 6.12095249127654e-06 7.49816680181376e-05 Adcy8/Kcnj16/Kcnj10/Kcnq1/Atp1a4/Atp1a3/Hrh2/Plcb2/Kcnj2/Slc9a4/Slc26a7/Adcy5/Atp1b2/Adcy4/Gnai1/Adcy1/Plcb1/Mylk2/Calm1/Itpr1/Adcy7/Car2/Prkcb/Cckbr/Mylk3/Camk2b/Cftr/Atp1a2/Camk2a 29 KEGG mmu04940 Type I diabetes mellitus 19/951 37/4976 9.91315615182532e-06 0.000114292859162221 H2-Q7/H2-Q8/H2-Q6/H2-Ab1/H2-Aa/Il12b/Fas/H2-Eb1/Cd28/H2-T24/H2-Q2/Fasl/Ica1/Ptprn/H2-Oa/Tnf/Cd86/H2-Q10/H2-DMb2 19 KEGG mmu04640 Hematopoietic cell lineage 29/951 70/4976 1.21453726599326e-05 0.000132249613408155 Cd4/Fcgr1/Il7/Mme/Tpo/Cd2/Itga4/Flt3/Cd33/Cd34/Cd38/Il7r/Itgb3/Csf3r/Csf3/Cd55b/Csf1r/H2-Eb1/Epor/Cd3d/Fcer2a/Cd8b1/Flt3l/Cd8a/Tnf/Itga1/Cd36/Il9r/Il11 29 KEGG mmu04062 Chemokine signaling pathway 54/951 166/4976 1.99257671988031e-05 0.000205550019524495 Adcy8/Gng3/Ccr2/Ccl21a/Was/Cxcl12/Cxcl9/Ccr5/Ccl11/Elmo1/Cxcl13/Pik3r5/Itk/Ccl3/Gng2/Pf4/Ccr1/Rac2/Cxcr4/Cxcl5/Plcb2/Gng13/Ccl22/Ccl8/Cx3cr1/Xcr1/Ccl28/Gngt2/Adcy5/Prex1/Adcy4/Ncf1/Nras/Gnai1/Dock2/Gnb4/Adcy1/Plcb1/Vav1/Shc2/Xcl1/Ccl7/Shc4/Ccl4/Adcy7/Cxcl2/Ccl12/Pik3cg/Prkcb/Ccl6/Cxcl10/Cxcl14/Gng8/Gnb3 54 KEGG mmu05416 Viral myocarditis 29/951 72/4976 2.31671159144215e-05 0.000227037735961331 H2-Q7/H2-Q8/H2-Q6/H2-Ab1/H2-Aa/Myh11/Cd55b/Rac2/H2-Eb1/Cd28/Fyn/Cd40/Itgb2/H2-T24/Myh1/Myh7/H2-Q2/Myh4/Icam1/Dmd/Lama2/Myh6/H2-Oa/Myh2/Itgb2l/Cd86/H2-Q10/H2-DMb2/Sgcb 29 KEGG mmu05144 Malaria 20/951 42/4976 2.45949851940765e-05 0.000229553195144714 Hgf/Ackr1/Selp/Gypc/Tlr9/Vcam1/Csf3/Sele/Pecam1/Sdc3/Tgfb2/Cd40/Itgb2/Thbs2/Icam1/Tnf/Cd36/Tgfb3/Gypa/Itgb2l 20 KEGG mmu04650 Natural killer cell mediated cytotoxicity 36/951 98/4976 2.80852674331103e-05 0.00025021420076771 Zap70/Lcp2/Pik3r5/Raet1a/Raet1b/Raet1d/Icam2/Cd244/Fcgr3/Fas/Cd48/Chp2/Rac2/Klrc1/Klra3/Klra8/Fyn/Itgb2/Nfatc4/Tnfsf10/Fcgr4/Nras/Hcst/Fasl/Icam1/Vav1/Shc2/Klrk1/Shc4/Tnf/Pik3cg/Prkcb/Lck/Fcer1g/Klrd1/Itgb2l 36 KEGG mmu04670 Leukocyte transendothelial migration 39/951 110/4976 3.37216523388401e-05 0.000287367124278811 Nox1/Cxcl12/Cldn11/Itga4/Cldn5/Rhoh/Pik3r5/Itk/Thy1/Myl9/Ctnna3/Vcam1/Cldn19/Txk/Pecam1/Actn3/Rac2/Cxcr4/Cdh5/Msn/Myl2/Itgb2/Mmp2/Ncf1/Esam/Gnai1/Cybb/Icam1/Mylpf/Vav1/Jam3/Pik3cg/Prkcb/Cldn8/Cldn10/Cldn20/Jam2/Itgb2l/Ncf4 39 KEGG mmu05146 Amoebiasis 35/951 97/4976 5.58811772569934e-05 0.00045636294759878 Arg2/Pik3r5/Lama4/Col4a4/Il12b/Col3a1/Serpinb1b/Actn3/Plcb2/Tgfb2/Col5a3/Serpinb1c/Itgb2/Lamc3/Serpinb10/Nos2/Adcy1/Plcb1/Serpinb9/Lama2/Col2a1/Serpinb3a/Col5a2/Tnf/Pik3cg/Col4a6/Prkcb/Tgfb3/Serpinb6c/Col4a1/Serpinb2/Itgb2l/Col1a2/Serpinb6b/Col5a1 35 KEGG mmu05323 Rheumatoid arthritis 27/951 69/4976 8.03257165810562e-05 0.000628691091651362 Atp6v0d2/Cxcl12/H2-Ab1/H2-Aa/Angpt1/Mmp3/Ccl3/Tek/Ctsk/Cxcl5/Pgf/H2-Eb1/Tgfb2/Cd28/Itgb2/Atp6v1c2/Flt1/Icam1/H2-Oa/Tnf/Tgfb3/Tnfsf13/Itgb2l/Cd86/H2-DMb2/Vegfa/Il11 27 KEGG mmu05410 Hypertrophic cardiomyopathy (HCM) 30/951 80/4976 8.33977978721195e-05 0.000628691091651362 Cacng4/Cacng7/Cacng5/Itgb8/Itga4/Igf1/Itgb3/Cacna1c/Tgfb2/Myl2/Ace/Myh7/Cacng8/Cacnb4/Tpm1/Itga8/Dmd/Itga9/Actc1/Lama2/Myh6/Itga11/Cacng1/Cacna2d4/Cacna1s/Tnf/Itga1/Tgfb3/Ttn/Sgcb 30 KEGG mmu05310 Asthma 9/951 13/4976 0.000111835123001218 0.000811840152156992 H2-Ab1/Ccl11/H2-Aa/H2-Eb1/Cd40/H2-Oa/Tnf/Fcer1g/H2-DMb2 9 KEGG mmu04972 Pancreatic secretion 30/951 82/4976 0.000140826811736619 0.000985787682156331 Adcy8/Kcnq1/Atp1a4/Pnliprp2/Atp1a3/Cd38/Pla2g2e/Atp2b3/Pla2g2f/Plcb2/Pla2g4e/Adcy5/Atp1b2/Atp2a3/Clca3b/Adcy4/Adcy1/Plcb1/Clca4b/Itpr1/Clca3a2/Atp2b4/Slc4a4/Adcy7/Car2/Prkcb/Atp2a1/Bst1/Cftr/Atp1a2 30 KEGG mmu04510 Focal adhesion 57/951 197/4976 0.000437178356523166 0.00295472268546691 Hgf/Col6a6/Flt4/Tnr/Itgb8/Itga4/Igf1/Kdr/Spp1/Pik3r5/Lama4/Col4a4/Myl9/Vwf/Pdgfd/Reln/Tnxb/Col3a1/Itgb3/Actn3/Rac2/Pgf/Vegfc/Mapk10/Col5a3/Myl2/Fyn/Pdgfrb/Tnc/Thbs2/Lamc3/Flt1/Itga8/Mylpf/Mylk2/Vav1/Shc2/Itga9/Lama2/Col2a1/Shc4/Itga11/Col6a3/Col5a2/Itga1/Pik3cg/Col4a6/Prkcb/Col4a1/Mylk3/Col6a2/Parvb/Vtn/Col1a2/Col6a4/Vegfa/Col5a1 57 KEGG mmu05340 Primary immunodeficiency 13/951 29/4976 0.00134976798492872 0.008818484168201 Cd4/Zap70/Ciita/Btk/Ptprc/Il7r/Cd40/Cd3d/Cd8b1/Cd8a/Aire/Lck/Il2rg 13 KEGG mmu04740 Olfactory transduction 23/951 65/4976 0.0014002842012149 0.00885340978832648 Olfr10/Olfr56/Prkg2/Pde1c/Olfr558/Adrbk2/Olfr684/Olfr1033/Clca3b/Olfr1392/Olfr691/Gucy2d/Cnga4/Clca4b/Calm1/Clca3a2/Olfr685/Olfr78/Prkg1/Camk2b/Olfr1420/Olfr1391/Camk2a 23 KEGG mmu04145 Phagosome 42/951 143/4976 0.00175827309641668 0.0107694227155522 Atp6v0d2/H2-Q7/H2-Q8/H2-Q6/Nox1/Olr1/Fcgr1/Clec7a/H2-Ab1/H2-Aa/Fcgr2b/Cd209b/Mrc1/Fcgr3/Itgb3/Cd209d/C1ra/Cd209a/H2-Eb1/Colec12/Itgb2/Dync1i1/H2-T24/H2-Q2/Thbs2/Fcgr4/Tubb4a/Atp6v1c2/Colec11/Tlr6/Ncf1/Cybb/Cd209f/H2-Oa/Cd36/Tubb1/Ctss/Coro1a/Itgb2l/H2-Q10/Ncf4/H2-DMb2 42 KEGG mmu04742 Taste transduction 13/951 30/4976 0.00197157869766596 0.0117099825679554 Asic2/Adcy8/Gng3/Pde1a/Plcb2/Gng13/Cacna1b/Adcy4/Scnn1b/Kcnb1/Tas2r108/Gnb3/Grm4 13 KEGG mmu04612 Antigen processing and presentation 21/951 61/4976 0.00326613565984353 0.0178040973126056 H2-Q7/Cd4/H2-Q8/H2-Q6/Ciita/H2-Ab1/H2-Aa/B2m/H2-Eb1/Klrc1/H2-T24/H2-Q2/Cd74/Cd8b1/Cd8a/H2-Oa/Tnf/Klrd1/Ctss/H2-Q10/H2-DMb2 21 KEGG mmu04730 Long-term depression 21/951 61/4976 0.00326613565984353 0.0178040973126056 Gucy1a2/Grm1/Igf1/Prkg2/Pla2g2e/Gucy1b3/Gucy1a3/Pla2g2f/Gria2/Plcb2/Pla2g4e/Nras/Gnai1/Plcb1/Itpr1/Grm5/Prkcb/Prkg1/Gnao1/Ryr1/Gria3 21 KEGG mmu05143 African trypanosomiasis 12/951 28/4976 0.00327014032272348 0.0178040973126056 Lama4/Il12b/Tlr9/Vcam1/Fas/Sele/Plcb2/Plcb1/Fasl/Icam1/Tnf/Prkcb 12 KEGG mmu05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 23/951 71/4976 0.00509941158520537 0.0269431306967743 Cacng4/Cdh2/Cacng7/Cacng5/Itgb8/Itga4/Lef1/Ctnna3/Itgb3/Cacna1c/Actn3/Cacng8/Cacnb4/Itga8/Dmd/Itga9/Lama2/Itga11/Cacng1/Cacna2d4/Cacna1s/Itga1/Sgcb 23 KEGG mmu04950 Maturity onset diabetes of the young 7/951 13/4976 0.00532336128670768 0.0269431306967743 Hnf4g/Foxa3/Bhlha15/Mafa/Hnf1a/Hhex/Slc2a2 7 KEGG mmu04672 Intestinal immune network for IgA production 13/951 33/4976 0.00536113314884795 0.0269431306967743 Cxcl12/Itga4/H2-Ab1/H2-Aa/Cxcr4/H2-Eb1/Cd28/Cd40/Ccl28/H2-Oa/Tnfsf13/Cd86/H2-DMb2 13 KEGG mmu02010 ABC transporters 15/951 42/4976 0.00831720609862981 0.0407543098832861 Abcb1a/Abcg5/Abca6/Abca4/Abcc9/Abca12/Abcc6/Abca8a/Abcc12/Abcd2/Abcg8/Abca9/Abca8b/Abcb1b/Cftr 15 KEGG mmu05140 Leishmaniasis 19/951 60/4976 0.0134749681466838 0.0644169208963419 Fcgr1/Itga4/H2-Ab1/H2-Aa/Il12b/Fcgr3/H2-Eb1/Tgfb2/Itgb2/Fcgr4/Ncf1/Nos2/H2-Oa/Tnf/Prkcb/Tgfb3/Itgb2l/Ncf4/H2-DMb2 19 KEGG mmu04973 Carbohydrate digestion and absorption 12/951 33/4976 0.0150088762049759 0.0700414222898876 Slc2a5/Atp1a4/Pik3r5/Atp1a3/Plcb2/Amy1/Atp1b2/Slc2a2/Pik3cg/Prkcb/Slc5a1/Atp1a2 12 KEGG mmu04916 Melanogenesis 27/951 95/4976 0.0171018075181637 0.0779524249665134 Adcy8/Creb3l1/Tyr/Tyrp1/Lef1/Wnt2b/Plcb2/Wnt16/Dct/Adcy5/Adcy4/Nras/Gnai1/Adcy1/Ednrb/Plcb1/Wnt10b/a/Calm1/Wnt8a/Creb3l3/Adcy7/Prkcb/Camk2b/Gnao1/Wnt10a/Camk2a 27 KEGG mmu04540 Gap junction 23/951 80/4976 0.0231690322340118 0.103207507224234 Adcy8/Gucy1a2/Grm1/Prkg2/Pdgfd/Gucy1b3/Gucy1a3/Plcb2/Pdgfrb/Htr2a/Tubb4a/Adcy5/Adcy4/Nras/Gnai1/Adcy1/Plcb1/Itpr1/Grm5/Adcy7/Prkcb/Tubb1/Prkg1 23 KEGG mmu04260 Cardiac muscle contraction 21/951 72/4976 0.0250138336096394 0.108949141944207 Cacng4/Cacng7/Cacng5/Atp1a4/Atp1a3/Cacna1c/Cox6a2/Myl2/Myh7/Cacng8/Cacnb4/Atp1b2/Tpm1/Actc1/Myh6/Cacng1/Cacna2d4/Cacna1s/Cox8b/Atp1a2/Cox7a1 21 KEGG mmu04340 Hedgehog signaling pathway 15/951 48/4976 0.029795741937867 0.12440730447116 Bmp5/Lrp2/Bmp8a/Wnt2b/Gli1/Ihh/Zic2/Wnt16/Bmp4/Wnt10b/Bmp2/Wnt8a/Ptch2/Wnt10a/Hhip 15 KEGG mmu05142 Chagas disease (American trypanosomiasis) 26/951 95/4976 0.0303123576624904 0.12440730447116 Pik3r5/Ccl3/Il12b/Tlr9/Fas/C1qb/Plcb2/Tgfb2/Mapk10/C1qa/Cd3d/Ace/C1qc/Tlr6/Gnai1/Nos2/Adcy1/Plcb1/Fasl/Ppp2r2c/Tnf/Pik3cg/Tgfb3/Serpine1/Gnao1/Tgfbr2 26 KEGG mmu00830 Retinol metabolism 13/951 40/4976 0.0304670949725289 0.12440730447116 Cyp2c65/Aldh1a2/Cyp26a1/Cyp4a30b/Cyp2c55/Cyp4a32/Rpe65/Dhrs9/Ugt1a6b/Cyp2a4/Rdh16/Rdh12/Ugt1a7c 13 KEGG mmu00591 Linoleic acid metabolism 7/951 18/4976 0.0408718927756564 0.163487571102625 Cyp2j8/Cyp2e1/Cyp2c65/Pla2g2e/Cyp2c55/Pla2g2f/Pla2g4e 7 KEGG mmu00910 Nitrogen metabolism 8/951 22/4976 0.0439599165874248 0.172322873022705 Car8/Car3/Car14/Car12/Car13/Car6/Car2/Car5a 8 KEGG mmu00590 Arachidonic acid metabolism 17/951 59/4976 0.0458443106377247 0.176185978137138 Cyp2j8/Cyp4f40/Cyp2e1/Cyp2c65/Gpx7/Cyp4a30b/Pla2g2e/Cyp2c55/Ptgds/Cyp4a32/Cyp4f18/Pla2g2f/Ltc4s/Alox12b/Pla2g4e/Gpx3/Ptgis 17 KEGG mmu04360 Axon guidance 32/951 126/4976 0.047796281010223 0.180155213038533 Dcc/Dpysl5/Sema4f/Sema6a/Epha6/Cxcl12/Ntng1/Slit1/Plxnc1/Epha3/Sema5b/Plxna4/Chp2/Rac2/Cxcr4/Robo2/Lrrc4c/Fyn/Nfatc4/Nrp1/Sema3g/Sema3c/Slit3/Nras/Gnai1/Robo3/Sema3a/Epha7/Sema6b/Sema3d/Rnd1/Dpysl2 32 KEGG mmu04380 Osteoclast differentiation 28/951 110/4976 0.0596842237017525 0.220719015953651 Fhl2/Nox1/Fcgr1/Btk/Pirb/Lcp2/Pik3r5/Fcgr2b/Trem2/Fcgr3/Itgb3/Ctsk/Csf1r/Tgfb2/Mapk10/Fyn/Fcgr4/Ncf1/Cybb/Tnf/Pik3cg/Gab2/Lck/Pira6/Pparg/Ncf4/Fosl1/Tgfbr2 28 KEGG mmu04964 Proximal tubule bicarbonate reclamation 7/951 20/4976 0.0703633607967406 0.25339242442915 Slc9a3/Atp1a4/Atp1a3/Atp1b2/Aqp1/Slc4a4/Atp1a2 7 KEGG mmu00512 Mucin type O-Glycan biosynthesis 8/951 24/4976 0.0711050170592002 0.25339242442915 Gcnt4/Wbscr17/Galnt16/Gcnt1/Galnt5/Galnt6/B4galt5/Galnt15 8 KEGG mmu04960 Aldosterone-regulated sodium reabsorption 12/951 41/4976 0.0768315334286019 0.268910367000107 Atp1a4/Igf1/Pik3r5/Atp1a3/Irs1/Atp1b2/Scnn1b/Hsd11b2/Pik3cg/Prkcb/Nr3c2/Atp1a2 12 KEGG mmu04720 Long-term potentiation 18/951 68/4976 0.0845775965237275 0.290828226642993 Adcy8/Ppp1r1a/Grm1/Cacna1c/Gria2/Chp2/Plcb2/Nras/Adcy1/Plcb1/Calm1/Itpr1/Grm5/Prkcb/Grin2a/Camk2b/Rps6ka6/Camk2a 18 KEGG mmu00340 Histidine metabolism 8/951 25/4976 0.087791814460371 0.296675786797116 Aspa/Uroc1/Hdc/Cndp1/Amdhd1/Maob/Hnmt/Ddc 8 KEGG mmu03320 PPAR signaling pathway 17/951 65/4976 0.100651324633669 0.334367112342359 Acaa1b/Scd3/Olr1/Rxrg/Cyp4a30b/Cyp4a32/Acsl6/Aqp7/Acox2/Pltp/Fabp4/Cd36/Fabp3/Hmgcs2/Nr1h3/Pparg/Slc27a5 17 KEGG mmu04930 Type II diabetes mellitus 12/951 44/4976 0.119203951233211 0.389399574028488 Pik3r5/Cacna1c/Mapk10/Irs1/Cacna1b/Mafa/Cacna1e/Tnf/Slc2a2/Socs2/Pik3cg/Cacna1g 12 KEGG mmu04975 Fat digestion and absorption 9/951 31/4976 0.121341513203599 0.389884206359104 Abcg5/Pnliprp2/Pla2g2e/Pla2g2f/Pla2g4e/Mogat2/Ppap2b/Abcg8/Cd36 9 KEGG mmu04664 Fc epsilon RI signaling pathway 17/951 67/4976 0.125425813732565 0.39650741115456 Btk/Lcp2/Pik3r5/Pla2g2e/Pla2g2f/Rac2/Mapk10/Inpp5d/Fyn/Pla2g4e/Nras/Vav1/Tnf/Pik3cg/Gab2/Prkcb/Fcer1g 17 KEGG mmu00601 Glycosphingolipid biosynthesis - lacto and neolacto series 7/951 23/4976 0.133108960933678 0.407646192859388 St3gal6/Fut4/St3gal4/St8sia1/Fut9/B4galt2/Fut2 7 KEGG mmu00760 Nicotinate and nicotinamide metabolism 7/951 23/4976 0.133108960933678 0.407646192859388 Nt5c1a/Cd38/Aox2/Enpp1/Bst1/Nt5e/Nnmt 7 KEGG mmu00514 Other types of O-glycan biosynthesis 9/951 32/4976 0.14174091703159 0.414760703713736 Fut4/Mfng/Gxylt2/Ugt1a6b/Fut9/B4galt2/Ugt1a7c/B3glct/Colgalt2 9 KEGG mmu00603 Glycosphingolipid biosynthesis - globo series 5/951 15/4976 0.141780444636838 0.414760703713736 B3galnt1/St8sia1/Fut9/Fut2/Gbgt1 5 KEGG mmu00604 Glycosphingolipid biosynthesis - ganglio series 5/951 15/4976 0.141780444636838 0.414760703713736 St6galnac4/St8sia5/St6galnac5/St8sia1/St6galnac6 5 KEGG mmu00380 Tryptophan metabolism 11/951 41/4976 0.144436991372044 0.416318386895893 Tph2/Tph1/Aadat/Aox2/Cyp1b1/Kynu/Tdo2/Maob/Ogdhl/Aanat/Ddc 11 KEGG mmu05218 Melanoma 16/951 64/4976 0.148065189373495 0.420590972713117 Hgf/Igf1/Fgf12/Pik3r5/Pdgfd/Fgf20/Fgf18/Fgf7/Fgf14/Fgf22/Pdgfrb/Nras/Fgf1/Fgf13/Fgfr1/Pik3cg 16 KEGG mmu04810 Regulation of actin cytoskeleton 44/951 199/4976 0.157118842103783 0.439932757890592 Fgfr4/Was/Chrm5/Itgb8/Itga4/Fgf12/Pik3r5/Itgax/Myl9/Pdgfd/Fgf20/Chrm2/Itgb3/Chrm1/Actn3/Rac2/Fgf18/Fgf7/Fgf14/Msn/Fgf22/Myl2/Itgb2/Pdgfrb/Nras/Apc2/Itga8/Mylpf/Mylk2/Vav1/Fgf1/Nckap1l/Itga9/Fgf13/Itga11/Fgfr1/Arhgef6/Itga1/Chrm4/Pik3cg/Insrr/Mylk3/Itgb2l/Pip5k1b 44 KEGG mmu00350 Tyrosine metabolism 9/951 33/4976 0.163757749318434 0.452063646005819 Tyr/Tyrp1/Tpo/Hgd/Aox2/Dct/Aoc3/Maob/Ddc 9 KEGG mmu00120 Primary bile acid biosynthesis 4/951 12/4976 0.182139681906766 0.494305179435247 Cyp7b1/Acox2/Cyp46a1/Slc27a5 4 KEGG mmu05145 Toxoplasmosis 26/951 114/4976 0.184103459687617 0.494305179435247 Ciita/Ccr5/H2-Ab1/H2-Aa/Pik3r5/Lama4/Pla2g2e/Il12b/Igtp/Pla2g2f/H2-Eb1/Tgfb2/Mapk10/Cd40/Pla2g4e/Lamc3/Gnai1/Nos2/Lama2/H2-Oa/Tnf/Pik3cg/Tgfb3/Gnao1/Il10ra/H2-DMb2 26 KEGG mmu04350 TGF-beta signaling pathway 19/951 81/4976 0.192648868071765 0.510259164081971 Bmp5/Smad9/Bmp8a/Gdf7/Bmpr1b/Tgfb2/Inhba/Amhr2/Thbs2/Gdf6/Ltbp1/Bmp4/Bmp2/Dcn/Nog/Tnf/Tgfb3/Acvr1c/Tgfbr2 19 KEGG mmu05217 Basal cell carcinoma 12/951 49/4976 0.213463062224171 0.557850135945832 Lef1/Wnt2b/Gli1/Wnt16/Bmp4/Apc2/Wnt10b/Bmp2/Wnt8a/Ptch2/Wnt10a/Hhip 12 KEGG mmu05322 Systemic lupus erythematosus 25/951 112/4976 0.222819803574776 0.574640546061265 Hist1h2be/C1s2/Fcgr1/C4b/Hc/H2-Ab1/H2-Aa/Fcgr2b/Fcgr3/C1qb/Actn3/C1ra/H2-Eb1/Cd28/C1qa/C1s1/Cd40/Fcgr4/C1qc/C2/H2-Oa/Tnf/Grin2a/Cd86/H2-DMb2 25 KEGG mmu04912 GnRH signaling pathway 20/951 89/4976 0.244455189528959 0.622249573346441 Adcy8/Pla2g2e/Cacna1c/Pla2g2f/Plcb2/Mapk10/Pla2g4e/Mmp2/Adcy5/Adcy4/Nras/Adcy1/Plcb1/Calm1/Itpr1/Cacna1s/Adcy7/Prkcb/Camk2b/Camk2a 20 KEGG mmu00982 Drug metabolism - cytochrome P450 12/951 51/4976 0.258103863909187 0.648568683669239 Cyp2e1/Cyp2c65/Fmo3/Cyp2c55/Cyp2d26/Aox2/Ugt1a6b/Cyp2a4/Mgst1/Maob/Cyp2d22/Ugt1a7c 12 KEGG mmu00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/951 14/4976 0.27145816479116 0.665072503738343 Chst1/Chst2/Chst5/B4galt2 4 KEGG mmu04614 Renin-angiotensin system 4/951 14/4976 0.27145816479116 0.665072503738343 Agtr1a/Mme/Agtr2/Ace 4 KEGG mmu04620 Toll-like receptor signaling pathway 19/951 86/4976 0.277835488420294 0.672293280621946 Cxcl9/Spp1/Pik3r5/Ccl3/Il12b/Tlr9/Ticam2/Ctsk/Lbp/Mapk10/Cd40/Tlr6/Ccl4/Tlr7/Tnf/Pik3cg/Irf7/Cxcl10/Cd86 19 KEGG mmu04530 Tight junction 27/951 126/4976 0.284156230854707 0.679202698140518 Cldn11/Cldn5/Myh11/Myl9/Hcls1/Ctnna3/Cldn19/Actn3/Magi2/Myl2/Myh1/Myh7/Myh4/Nras/Gnai1/Mylpf/Ppp2r2c/Jam3/Myh6/Rab3b/Prkcb/Cldn8/Cldn10/Cldn20/Jam2/Myh2/Epb41l2 27 KEGG mmu00232 Caffeine metabolism 2/951 6/4976 0.322808163810981 0.762293977192195 Nat3/Cyp2a4 2 KEGG mmu04370 VEGF signaling pathway 15/951 69/4976 0.333496058232952 0.778157469210221 Kdr/Nos3/Pik3r5/Pla2g2e/Pla2g2f/Chp2/Rac2/Pla2g4e/Nfatc4/Nras/Shc2/Sh2d2a/Pik3cg/Prkcb/Vegfa 15 KEGG mmu05020 Prion diseases 7/951 30/4976 0.345346221656294 0.796327758172159 Hc/Casp12/Ncam1/C1qb/C1qa/Fyn/C1qc 7 KEGG mmu00140 Steroid hormone biosynthesis 6/951 26/4976 0.377224919825718 0.851622699000655 Cyp7b1/Cyp1b1/Ugt1a6b/Hsd11b2/Hsd17b1/Ugt1a7c 6 KEGG mmu04662 B cell receptor signaling pathway 15/951 71/4976 0.378016198025801 0.851622699000655 Card11/Pik3ap1/Btk/Pirb/Pik3r5/Fcgr2b/Rasgrp3/Chp2/Rac2/Inpp5d/Nfatc4/Nras/Vav1/Pik3cg/Prkcb 15 KEGG mmu04666 Fc gamma R-mediated phagocytosis 18/951 87/4976 0.395232915487102 0.88029149358491 Was/Fcgr1/Ptprc/Pik3r5/Fcgr2b/Amph/Rac2/Inpp5d/Pla2g4e/Dnm1/Ncf1/Dock2/Vav1/Ppap2b/Pik3cg/Gab2/Prkcb/Pip5k1b 18 KEGG mmu04630 Jak-STAT signaling pathway 24/951 118/4976 0.402598566406654 0.881216334671589 Il12rb2/Il21r/Il7/Csf2rb2/Il13ra2/Lepr/Tpo/Pik3r5/Il2rb/Il7r/Il12b/Csf2rb/Csf3r/Csf3/Epor/Il12rb1/Socs2/Pik3cg/Il22ra2/Il9r/Il10ra/Il2rg/Lep/Il11 24 KEGG mmu00230 Purine metabolism 31/951 154/4976 0.40464015367573 0.881216334671589 Adcy8/Gucy2f/Ak5/Nt5c1a/Gucy1a2/Pde1b/Pde1a/Npr1/Pde1c/Gucy1b3/Gucy1a3/Pde3a/Npr2/Pde3b/Pde11a/Adcy5/Pde8b/Pde10a/Adcy4/Adcy1/Gucy2d/Ak7/Adcy7/Pde6b/Enpp1/Pde4c/Adssl1/Gucy2c/Nt5e/Pde7b/Pde2a 31 KEGG mmu04744 Phototransduction 6/951 27/4976 0.41460315879615 0.892991418945554 Gucy2f/Rgs9/Rcvrn/Gucy2d/Calm1/Pde6b 6 KEGG mmu04660 T cell receptor signaling pathway 20/951 99/4976 0.430728302638601 0.915551268995807 Card11/Cd4/Zap70/Ptprc/Lcp2/Pik3r5/Itk/Chp2/Cd28/Fyn/Cd3d/Nfatc4/Cd8b1/Nras/Pdcd1/Vav1/Cd8a/Tnf/Pik3cg/Lck 20 KEGG mmu04622 RIG-I-like receptor signaling pathway 11/951 53/4976 0.434419734778623 0.915551268995807 Tbkbp1/Il12b/Mapk10/Isg15/Rnf125/Dhx58/Tnf/Irf7/Cxcl10/Sike1/Tmem173 11 KEGG mmu00600 Sphingolipid metabolism 8/951 38/4976 0.444190501621302 0.926184450189097 Sgpp2/Ugt8a/Smpd3/Acer1/Sptlc3/Ppap2b/Neu2/B4galt6 8 KEGG mmu04010 MAPK signaling pathway 48/951 248/4976 0.48706072718989 0.999999999998803 Cacng4/Fgfr4/Cacng7/Cacng5/Fgf12/Pla2g2e/Fgf20/Fas/Rasgrp3/Cacna1c/Pla2g2f/Chp2/Rac2/Fgf18/Fgf7/Fgf14/Tgfb2/Mapk10/Fgf22/Pdgfrb/Dusp8/Pla2g4e/Nfatc4/Cacng8/Cacnb4/Cacna1b/Nras/Fasl/Fgf1/Ntrk2/Cacna1e/Fgf13/Fgfr1/Cacng1/Cacna2d4/Cacna1s/Mapk8ip2/Tnf/Cacna1h/Prkcb/Tgfb3/Nr4a1/Mef2c/Ptprr/Cacna1g/Rps6ka6/Ptpn7/Tgfbr2 48 KEGG mmu00330 Arginine and proline metabolism 10/951 50/4976 0.493273847283303 0.999999999998803 Gatm/Arg2/Agmat/Nos3/Ckb/Ckm/Nos2/Ckmt2/Maob/Aldh18a1 10 KEGG mmu04310 Wnt signaling pathway 27/951 139/4976 0.497165503818244 0.999999999998803 Wif1/Sfrp2/Lef1/Wnt2b/Sfrp5/Dkk2/Chp2/Rac2/Nkd1/Plcb2/Wnt16/Mapk10/Nfatc4/Nkd2/Sfrp4/Apc2/Plcb1/Wnt10b/Mmp7/Daam2/Wnt8a/Prkcb/Camk2b/Wnt10a/Cxxc4/Fosl1/Camk2a 27 KEGG mmu00592 alpha-Linolenic acid metabolism 3/951 14/4976 0.518278589572806 0.999999999998803 Pla2g2e/Pla2g2f/Pla2g4e 3 KEGG mmu00565 Ether lipid metabolism 6/951 30/4976 0.52400097001252 0.999999999998803 Pla2g2e/Pla2g2f/Pla2g4e/Enpp6/Ppap2b/Enpp2 6 KEGG mmu00500 Starch and sucrose metabolism 6/951 31/4976 0.558685853870502 0.999999999998803 Gys2/Amy1/Ugt1a6b/Pygm/Enpp1/Ugt1a7c 6 KEGG mmu04623 Cytosolic DNA-sensing pathway 8/951 42/4976 0.566718850330069 0.999999999998803 Zbp1/Casp1/Aim2/Ccl4/Irf7/Cxcl10/Tmem173/Trex1 8 KEGG mmu00053 Ascorbate and aldarate metabolism 3/951 15/4976 0.568194812117824 0.999999999998803 Gulo/Ugt1a6b/Ugt1a7c 3 KEGG mmu00360 Phenylalanine metabolism 3/951 15/4976 0.568194812117824 0.999999999998803 Aoc3/Maob/Ddc 3 KEGG mmu00260 Glycine, serine and threonine metabolism 6/951 32/4976 0.592137869102592 0.999999999998803 Gatm/Sardh/Pipox/Aoc3/Maob/Tdh 6 KEGG mmu00072 Synthesis and degradation of ketone bodies 2/951 10/4976 0.597003269707112 0.999999999998803 Bdh2/Hmgcs2 2 KEGG mmu00980 Metabolism of xenobiotics by cytochrome P450 8/951 44/4976 0.623323216548958 0.999999999998803 Cyp2e1/Cyp2c65/Cyp2c55/Cyp2f2/Cyp1b1/Ugt1a6b/Mgst1/Ugt1a7c 8 KEGG mmu04070 Phosphatidylinositol signaling system 14/951 77/4976 0.628873618415445 0.999999999998803 Pik3r5/Plcb2/Inpp5d/Inpp4b/Plcb1/Itpka/Calm1/Itpr1/Pik3cg/Dgkg/Prkcb/Inpp5j/Pip5k1b/Dgkb 14 KEGG mmu00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 4/951 22/4976 0.629738768189942 0.999999999998803 Chst7/Dse/Chst13/Ust 4 KEGG mmu05200 Pathways in cancer 56/951 303/4976 0.637258522944249 0.999999999998803 Dcc/Hgf/Ar/Rxrg/Flt3/Igf1/Lef1/Fgf12/Pik3r5/Wnt2b/Lama4/Col4a4/Runx1t1/Gli1/Fgf20/Ctnna3/Fas/Csf3r/Rac2/Fgf18/Fgf7/Pgf/Csf1r/Vegfc/Fgf14/Tgfb2/Wnt16/Mapk10/Fgf22/Pdgfrb/Mmp2/Lamc3/Bmp4/Nras/Apc2/Nos2/Fasl/Wnt10b/Flt3l/Fgf1/Bmp2/Fgf13/Lama2/Wnt8a/Fgfr1/Ptch2/Pik3cg/Col4a6/Prkcb/Tgfb3/Col4a1/Wnt10a/Pparg/Hhip/Vegfa/Tgfbr2 56 KEGG mmu00740 Riboflavin metabolism 2/951 11/4976 0.651207046276906 0.999999999998803 Tyr/Enpp1 2 KEGG mmu04520 Adherens junction 13/951 73/4976 0.659105853470063 0.999999999998803 Was/Lef1/Snai1/Ptprm/Ctnna3/Pvrl3/Actn3/Rac2/Fyn/Ptprb/Fgfr1/Ptpn1/Tgfbr2 13 KEGG mmu04914 Progesterone-mediated oocyte maturation 14/951 80/4976 0.688300739275085 0.999999999998803 Adcy8/Igf1/Pik3r5/Ccna1/Pde3a/Mapk10/Pde3b/Adcy5/Adcy4/Gnai1/Adcy1/Adcy7/Pik3cg/Rps6ka6 14 KEGG mmu00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/951 24/4976 0.700374299772253 0.999999999998803 Hs6st3/Ndst3/Hs3st5/Hs6st2 4 KEGG mmu05214 Glioma 11/951 65/4976 0.722251691314341 0.999999999998803 Igf1/Pik3r5/Pdgfrb/Nras/Shc2/Calm1/Shc4/Pik3cg/Prkcb/Camk2b/Camk2a 11 KEGG mmu00410 beta-Alanine metabolism 3/951 20/4976 0.765726133783091 0.999999999998803 Abat/Cndp1/Aoc3 3 KEGG mmu05210 Colorectal cancer 10/951 62/4976 0.773214157271885 0.999999999998803 Dcc/Lef1/Pik3r5/Rac2/Tgfb2/Mapk10/Apc2/Pik3cg/Tgfb3/Tgfbr2 10 KEGG mmu00750 Vitamin B6 metabolism 1/951 7/4976 0.773658015575097 0.999999999998803 Aox2 1 KEGG mmu04150 mTOR signaling pathway 8/951 51/4976 0.785586336773187 0.999999999998803 Igf1/Pik3r5/Pgf/Vegfc/Pik3cg/Eif4e1b/Rps6ka6/Vegfa 8 KEGG mmu04320 Dorso-ventral axis formation 3/951 21/4976 0.794903296531599 0.999999999998803 Fmn2/Ets1/Notch4 3 KEGG mmu04966 Collecting duct acid secretion 3/951 21/4976 0.794903296531599 0.999999999998803 Atp6v0d2/Atp6v1c2/Car2 3 KEGG mmu05014 Amyotrophic lateral sclerosis (ALS) 8/951 52/4976 0.803860928687463 0.999999999998803 Nefm/Casp12/Casp1/Gria2/Chp2/Nefl/Tnf/Grin2a 8 KEGG mmu05212 Pancreatic cancer 11/951 70/4976 0.809092659015218 0.999999999998803 Pik3r5/Rac2/Pgf/Vegfc/Tgfb2/Mapk10/Arhgef6/Pik3cg/Tgfb3/Vegfa/Tgfbr2 11 KEGG mmu05216 Thyroid cancer 4/951 28/4976 0.811229688346891 0.999999999998803 Rxrg/Lef1/Nras/Pparg 4 KEGG mmu05160 Hepatitis C 19/951 117/4976 0.819995726440289 0.999999999998803 Cldn11/Cldn5/Pik3r5/Ifit1/Cldn19/Oas2/Mapk10/Nras/Oas1b/Ppp2r2c/Oas1a/Oas3/Tnf/Pik3cg/Irf7/Cldn8/Cldn10/Cldn20/Nr1h3 19 KEGG mmu00040 Pentose and glucuronate interconversions 3/951 22/4976 0.820981906269755 0.999999999998803 Ugt1a6b/Ugt1a7c/Xylb 3 KEGG mmu04710 Circadian rhythm 3/951 22/4976 0.820981906269755 0.999999999998803 Arntl/Per1/Per2 3 KEGG mmu04920 Adipocytokine signaling pathway 10/951 66/4976 0.836777120702483 0.999999999998803 Rxrg/Lepr/Mapk10/Acsl6/Irs1/Tnf/Cd36/Acacb/Lep/Npy 10 KEGG mmu04330 Notch signaling pathway 7/951 48/4976 0.838131679559533 0.999999999998803 Dtx1/Rbpjl/Mfng/Notch4/Aph1c/Dtx4/Dll4 7 KEGG mmu04910 Insulin signaling pathway 21/951 131/4976 0.846923321947141 0.999999999998803 Gys2/Pik3r5/Prkar1b/Pde3a/Mapk10/Inpp5d/Irs1/Pde3b/Nras/Ppp1r3a/Pygm/Ppp1r3b/Shc2/Calm1/Shc4/Socs2/Pik3cg/Eif4e1b/Acacb/Phkg1/Ptpn1 21 KEGG mmu00920 Sulfur metabolism 1/951 9/4976 0.852012068655569 0.999999999998803 Chst13 1 KEGG mmu05215 Prostate cancer 13/951 85/4976 0.852180121973671 0.999999999998803 Creb3l1/Ar/Igf1/Lef1/Pik3r5/Creb5/Pdgfd/Pdgfrb/Nras/Fgfr1/Creb3l3/Pik3cg/Insrr 13 KEGG mmu00250 Alanine, aspartate and glutamate metabolism 4/951 30/4976 0.852647404638049 0.999999999998803 Aspa/Gfpt2/Abat/Adssl1 4 KEGG mmu04621 NOD-like receptor signaling pathway 8/951 56/4976 0.865290150407204 0.999999999998803 Naip5/Nlrp1a/Casp1/Mapk10/Naip6/Naip7/Tnf/Cxcl2 8 KEGG mmu03450 Non-homologous end-joining 1/951 10/4976 0.880346379649842 0.999999999998803 Fen1 1 KEGG mmu00650 Butanoate metabolism 3/951 25/4976 0.882843212116422 0.999999999998803 Abat/Bdh2/Hmgcs2 3 KEGG mmu05211 Renal cell carcinoma 10/951 70/4976 0.885619682120047 0.999999999998803 Hgf/Pik3r5/Pgf/Vegfc/Tgfb2/Nras/Ets1/Pik3cg/Tgfb3/Vegfa 10 KEGG mmu00561 Glycerolipid metabolism 6/951 46/4976 0.897549961300349 0.999999999998803 Agpat4/Pnliprp2/Ppap2b/Mboat2/Dgkg/Dgkb 6 KEGG mmu05219 Bladder cancer 5/951 40/4976 0.903925422951107 0.999999999998803 Pgf/Vegfc/Mmp2/Nras/Vegfa 5 KEGG mmu04114 Oocyte meiosis 15/951 104/4976 0.916251324428609 0.999999999998803 Adcy8/Ar/Igf1/Chp2/Adcy5/Adcy4/Adcy1/Calm1/Itpr1/Ywhag/Adcy7/Rec8/Camk2b/Rps6ka6/Camk2a 15 KEGG mmu04977 Vitamin digestion and absorption 2/951 20/4976 0.918099177599326 0.999999999998803 Folh1/Cubn 2 KEGG mmu00562 Inositol phosphate metabolism 7/951 55/4976 0.922930767178 0.999999999998803 Plcb2/Inpp4b/Plcb1/Itpka/Pik3cg/Inpp5j/Pip5k1b 7 KEGG mmu04962 Vasopressin-regulated water reabsorption 5/951 42/4976 0.925209625520578 0.999999999998803 Creb3l1/Creb5/Aqp4/Dync1i1/Creb3l3 5 KEGG mmu05100 Bacterial invasion of epithelial cells 9/951 69/4976 0.931635703747382 0.999999999998803 Was/Elmo1/Pik3r5/Hcls1/Ctnna3/Dnm1/Shc2/Shc4/Pik3cg 9 KEGG mmu04210 Apoptosis 11/951 82/4976 0.933844762824453 0.999999999998803 Csf2rb2/Casp12/Pik3r5/Csf2rb/Fas/Prkar1b/Chp2/Tnfsf10/Fasl/Tnf/Pik3cg 11 KEGG mmu00860 Porphyrin and chlorophyll metabolism 3/951 29/4976 0.935497248125184 0.999999999998803 Cp/Ugt1a6b/Ugt1a7c 3 KEGG mmu05221 Acute myeloid leukemia 7/951 57/4976 0.938618119613153 0.999999999998803 Flt3/Lef1/Pik3r5/Runx1t1/Ccna1/Nras/Pik3cg 7 KEGG mmu01040 Biosynthesis of unsaturated fatty acids 2/951 22/4976 0.942075690961178 0.999999999998803 Acaa1b/Scd3 2 KEGG mmu00770 Pantothenate and CoA biosynthesis 1/951 14/4976 0.948888711522142 0.999999999998803 Enpp1 1 KEGG mmu00900 Terpenoid backbone biosynthesis 1/951 14/4976 0.948888711522142 0.999999999998803 Hmgcs2 1 KEGG mmu00983 Drug metabolism - other enzymes 4/951 38/4976 0.949910576277772 0.999999999998803 Nat3/Ugt1a6b/Cyp2a4/Ugt1a7c 4 KEGG mmu05213 Endometrial cancer 6/951 52/4976 0.949991568092795 0.999999999998803 Lef1/Pik3r5/Ctnna3/Nras/Apc2/Pik3cg 6 KEGG mmu00640 Propanoate metabolism 3/951 31/4976 0.952675406644088 0.999999999998803 Acss3/Abat/Acacb 3 KEGG mmu00564 Glycerophospholipid metabolism 9/951 73/4976 0.955383583798874 0.999999999998803 Agpat4/Pla2g2e/Pla2g2f/Pla2g4e/Ppap2b/Mboat2/Dgkg/Dgkb/Gpd1 9 KEGG mmu05220 Chronic myeloid leukemia 9/951 73/4976 0.955383583798874 0.999999999998803 Pik3r5/Tgfb2/Nras/Shc2/Shc4/Pik3cg/Gab2/Tgfb3/Tgfbr2 9 KEGG mmu00511 Other glycan degradation 1/951 16/4976 0.966604505626775 0.999999999998803 Neu2 1 KEGG mmu03410 Base excision repair 3/951 34/4976 0.970612564034728 0.999999999998803 Neil2/Parp3/Fen1 3 KEGG mmu05222 Small cell lung cancer 10/951 84/4976 0.972527453772158 0.999999999998803 Rxrg/Pik3r5/Lama4/Col4a4/Lamc3/Nos2/Lama2/Pik3cg/Col4a6/Col4a1 10 KEGG mmu00531 Glycosaminoglycan degradation 1/951 17/4976 0.973007553035835 0.999999999998803 Hpse2 1 KEGG mmu04012 ErbB signaling pathway 10/951 85/4976 0.975424002173052 0.999999999998803 Pik3r5/Mapk10/Nras/Shc2/Shc4/Pik3cg/Nrg4/Prkcb/Camk2b/Camk2a 10 KEGG mmu00100 Steroid biosynthesis 1/951 18/4976 0.978183963010209 0.999999999998803 Soat2 1 KEGG mmu00071 Fatty acid degradation 4/951 44/4976 0.979266660314227 0.999999999998803 Acaa1b/Cyp4a30b/Cyp4a32/Acsl6 4 KEGG mmu00310 Lysine degradation 4/951 45/4976 0.982188595166043 0.999999999998803 Aadat/Pipox/Ogdhl/Colgalt2 4 KEGG mmu05223 Non-small cell lung cancer 5/951 54/4976 0.985471068785047 0.999999999998803 Rxrg/Pik3r5/Nras/Pik3cg/Prkcb 5 KEGG mmu04722 Neurotrophin signaling pathway 15/951 128/4976 0.991502480991303 0.999999999998803 Pik3r5/Ntrk3/Mapk10/Irs1/Nras/Fasl/Shc2/Ntrk2/Calm1/Shc4/Ywhag/Pik3cg/Camk2b/Rps6ka6/Camk2a 15 KEGG mmu05012 Parkinson's disease 15/951 128/4976 0.991502480991303 0.999999999998803 Slc18a2/Ube2l6/Lrrk2/Cox6a2/Uchl1/Ndufa13/Ube2l3/Gm10705/Cox8b/ATP8/ND2/ND4L/Sncaip/Cox7a1/ND4 15 KEGG mmu00280 Valine, leucine and isoleucine degradation 4/951 50/4976 0.991814964515547 0.999999999998803 Acaa1b/Abat/Aox2/Hmgcs2 4 KEGG mmu05010 Alzheimer's disease 21/951 168/4976 0.992253343254469 0.999999999998803 Mme/Casp12/Fas/Cacna1c/Chp2/Ryr3/Plcb2/Cox6a2/Atp2a3/Plcb1/Calm1/Itpr1/Cacna1s/Ndufa13/Tnf/Aph1c/Grin2a/Atp2a1/Cox8b/ATP8/Cox7a1 21 KEGG mmu00051 Fructose and mannose metabolism 2/951 34/4976 0.99346105800722 0.999999999998803 Mtmr7/Pfkfb3 2 KEGG mmu00052 Galactose metabolism 1/951 24/4976 0.993925078306126 0.999999999998803 B4galt2 1 KEGG mmu04146 Peroxisome 7/951 76/4976 0.994606911810932 0.999999999998803 Acaa1b/Pipox/Acsl6/Nos2/Acox2/Abcd2/Pxmp2 7 KEGG mmu00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 1/951 25/4976 0.995091728251779 0.999999999998803 Pigz 1 KEGG mmu00520 Amino sugar and nucleotide sugar metabolism 3/951 47/4976 0.996712745894724 0.999999999998803 Gfpt2/Npl/Chil1 3 KEGG mmu00510 N-Glycan biosynthesis 3/951 48/4976 0.997240888304367 0.999999999998803 Alg2/B4galt2/Man1c1 3 KEGG mmu04144 Endocytosis 25/951 205/4976 0.997385528611568 0.999999999998803 Fgfr4/H2-Q7/H2-Q8/H2-Q6/Acap1/Ccr5/Kdr/Il2rb/Arap3/Cxcr4/Csf1r/Tgfb2/H2-T24/Dnm1/H2-Q2/Dab2/Flt1/Psd2/Tgfb3/Rab22a/Pip5k1b/H2-Q10/Il2rg/Mvb12b/Tgfbr2 25 KEGG mmu00620 Pyruvate metabolism 2/951 39/4976 0.997458396863809 0.999999999998803 Acot12/Acacb 2 KEGG mmu00480 Glutathione metabolism 3/951 50/4976 0.99806072275791 0.999999999998803 Gpx7/Gpx3/Mgst1 3 KEGG mmu00020 Citrate cycle (TCA cycle) 1/951 30/4976 0.998311289389095 0.999999999998803 Ogdhl 1 KEGG mmu05016 Huntington's disease 19/951 174/4976 0.998951769422634 0.999999999998803 Creb3l1/Dnah3/Grm1/Creb5/Dnah2/Plcb2/Cox6a2/Dlg4/Hip1/Plcb1/Itpr1/Ndufa13/Creb3l3/Dnaic2/Grm5/Cox8b/ATP8/Pparg/Cox7a1 19 KEGG mmu04115 p53 signaling pathway 4/951 64/4976 0.999184010862407 0.999999999998803 Igf1/Fas/Igfbp3/Serpine1 4 KEGG mmu04130 SNARE interactions in vesicular transport 1/951 34/4976 0.999281411208633 0.999999999998803 Stx1b 1 KEGG mmu03030 DNA replication 1/951 35/4976 0.999419690840481 0.999999999998803 Fen1 1 KEGG mmu00190 Oxidative phosphorylation 11/951 128/4976 0.99973900674671 0.999999999998803 Atp6v0d2/Cox6a2/Atp6v1c2/Ndufa13/Atp12a/Cox8b/ATP8/ND2/ND4L/Cox7a1/ND4 11 KEGG mmu00010 Glycolysis / Gluconeogenesis 2/951 52/4976 0.999795348628383 0.999999999998803 Eno2/Pgam2 2 KEGG mmu00970 Aminoacyl-tRNA biosynthesis 1/951 42/4976 0.999870184860974 0.999999999998803 Pars2 1 KEGG mmu03018 RNA degradation 3/951 66/4976 0.999894529953411 0.999999999998803 Lsm5/Eno2/C1d 3 KEGG mmu04142 Lysosome 8/951 117/4976 0.999961023534499 0.999999999998803 Atp6v0d2/Napsa/Ctsk/Dnase2b/Arsg/Ctsw/Laptm5/Ctss 8 KEGG mmu03010 Ribosome 4/951 88/4976 0.99998837248684 0.999999999998803 Rpl29/Rpl39l/Rps27a/Rpl3l 4 KEGG mmu03015 mRNA surveillance pathway 2/951 77/4976 0.999998628673689 0.999999999998803 Papolb/Ppp2r2c 2 KEGG mmu00240 Pyrimidine metabolism 3/951 92/4976 0.999999266612547 0.999999999998803 Nt5c1a/Cmpk2/Nt5e 3 KEGG mmu04120 Ubiquitin mediated proteolysis 7/951 134/4976 0.999999459022153 0.999999999998803 Ube2ql1/Fbxo2/Ube2l6/Klhl13/Aire/Ube2l3/Gm10705 7 KEGG mmu03008 Ribosome biogenesis in eukaryotes 1/951 72/4976 0.999999793710505 0.999999999998803 Rrp7a 1 KEGG mmu04141 Protein processing in endoplasmic reticulum 8/951 160/4976 0.999999970324894 0.999999999998803 Fbxo2/Casp12/Dnajc5/Mapk10/Lman1l/Erp29/Man1c1/Hsph1 8 KEGG mmu04110 Cell cycle 4/951 121/4976 0.999999976837654 0.999999999998803 Ccna1/Tgfb2/Ywhag/Tgfb3 4 KEGG mmu01100 Metabolic pathways 131/951 1032/4976 0.999999999634889 0.999999999998803 Ak5/Gatm/Acaa1b/Tyr/Tyrp1/Pon1/Atp6v0d2/Nt5c1a/Arg2/Cyp2j8/Ugt8a/Cyp4f40/Cyp2e1/Agpat4/Tph2/Cyp2c65/Tph1/Aldh1a2/Tpo/Agmat/Gcnt4/Cyp4a30b/B3galnt1/Nos3/Pnliprp2/Gfpt2/Smpd3/Cmpk2/Cd38/Acss3/Pla2g2e/Wbscr17/Ndst3/Galnt16/Cyp2c55/Ptgds/St6galnac4/Uroc1/St8sia5/St3gal6/Nat3/Cyp4a32/Hdc/Cyp4f18/Abat/Aadat/Bdh2/Pla2g2f/Sardh/Gcnt1/St6galnac5/Ltc4s/Hgd/Plcb2/Ckb/Pipox/Fut4/Amy1/Cox6a2/Acer1/Acsl6/Aox2/Dct/Dhrs9/St3gal4/Alox12b/Galnt5/Pla2g4e/Hpse2/St8sia1/Alg2/Ckm/Atp6v1c2/Kynu/Tdo2/Gulo/Ugt1a6b/Cndp1/Cyp2a4/Inpp4b/Fut9/Amdhd1/Nos2/Plcb1/Eno2/Sptlc3/Acox2/Itpka/Aoc3/Ckmt2/Ppap2b/Pgam2/Mboat2/B4galt2/Maob/Rdh16/Galnt6/Ogdhl/Ak7/Enpp1/Ptgis/Aanat/Hsd11b2/Dgkg/Galnt15/Rdh12/Hsd17b1/Inpp5j/Ddc/Adssl1/Cox8b/Bst1/Nt5e/St6galnac6/ATP8/Man1c1/Fut2/Acacb/Hmgcs2/ND2/Pip5k1b/Gbgt1/Ugt1a7c/ND4L/Nnmt/Dgkb/B4galt6/Xylb/ND4/Slc27a5/Aldh18a1 131 KEGG mmu03040 Spliceosome 1/951 122/4976 0.999999999995954 0.999999999998803 Lsm5 1 KEGG mmu03013 RNA transport 2/951 144/4976 0.999999999998803 0.999999999998803 Eef1a2/Eif4e1b 2