Table S5 Differentially expressed genes in lymphoblasts with |log2 fold change | > 0.69 and adjusted P value < 0.001 PROBEID logFC AveExpr t adj.P.Val B SYMBOL 213831_at 2.979400784 10.91752008 5.548881765 1.77E-05 4.648850761 HLA-DQA1 224588_at 2.57063797 8.347539806 6.229187482 2.75E-06 6.833445647 XIST 212698_s_at 1.704764456 8.123264029 7.011575071 3.39E-07 9.348159155 SEPTIN10 219759_at 1.498926133 9.054174777 5.253085451 3.96E-05 3.707686214 ERAP2 204992_s_at 1.43822137 7.264304233 7.557624121 8.31E-08 11.08680989 PFN2 202436_s_at 1.317108808 8.409178443 5.364156384 2.92E-05 4.060137293 CYP1B1 221491_x_at 1.244135444 8.727119282 7.263316336 1.72E-07 10.15215223 HLA-DRB1//HLA-DQB1//HLA-DRB3//HLA-DRB4//HLA-DRB5//HLA-DRB6 217963_s_at 1.22364906 8.027232919 7.305180821 1.56E-07 10.28547854 BEX3 202315_s_at 1.223231008 6.986498289 8.24616345 1.39E-08 13.2449313 BCR 201387_s_at 1.194142173 9.14106377 4.753666603 0.000151458 2.142419376 UCHL1 203476_at 1.18652137 6.527919287 5.23459125 4.17E-05 3.649127488 TPBG 201012_at 1.128332385 6.776388853 7.409783922 1.19E-07 10.61808566 ANXA1 226003_at 1.023708798 8.344745337 6.329735247 2.10E-06 7.157239101 KIF21A 217901_at 0.95913556 8.563681883 6.583798735 1.05E-06 7.975067783 DSG2 204141_at 0.861023215 10.47049903 7.273669519 1.68E-07 10.18513491 TUBB2A 206760_s_at 0.857125481 10.60364275 7.085691657 2.79E-07 9.585245396 FCER2 223253_at 0.835099206 7.90535599 5.250994012 3.98E-05 3.701062125 EPDR1 227189_at 0.826442914 9.759170221 10.36857859 7.63E-11 19.55863633 CPNE5 204115_at 0.795171577 6.835120391 6.7630532 6.53E-07 8.551269044 GNG11 206167_s_at 0.790345096 6.80383576 5.755861614 1.00E-05 5.311449782 ARHGAP6 213103_at 0.783065723 6.308498626 7.761706667 4.83E-08 11.73097669 STARD13 226609_at 0.781816952 6.880276078 15.17289271 5.57E-15 31.66033727 DCBLD1 209030_s_at 0.778745399 7.16953078 4.640631436 0.000204668 1.79376601 CADM1 207761_s_at 0.744021861 9.213995809 4.11986883 0.00080146 0.224186317 METTL7A 214805_at 0.74214516 9.434970113 10.89664257 2.50E-11 21.0383529 EIF4A1//SNORA67//SNORA48//SNORD10 224818_at 0.738490578 7.367932595 7.279355233 1.66E-07 10.2032452 SORT1 226625_at 0.717089402 6.527173129 4.402287952 0.000384561 1.067244319 TGFBR3 227492_at 0.71612765 7.475643596 6.611178228 9.70E-07 8.063135424 OCLN 1552309_a_at 0.709698543 6.850343927 7.481095718 1.01E-07 10.84438521 NEXN 223948_s_at 0.702923479 6.130818894 4.101931656 0.000838069 0.171380396 TMPRSS3 204342_at 0.69907491 7.435024914 6.598627086 1.00E-06 8.022766224 SLC25A24 1558678_s_at 0.69741386 10.56072053 7.928782488 3.14E-08 12.25563266 MALAT1 229770_at 0.694299966 6.758194114 4.228962307 0.000607974 0.547324826 GLT1D1 218251_at -0.69219284 8.895378653 -11.18171744 1.61E-11 21.82141469 MID1IP1 212458_at -0.695298508 6.675428231 -6.023411646 4.92E-06 6.171050115 SPRED2 219312_s_at -0.696043215 5.766521639 -6.004630122 5.18E-06 6.110630233 ZBTB10 204148_s_at -0.696800217 6.488568838 -5.162135596 5.05E-05 3.420087761 POMZP3//ZP3 239186_at -0.700672431 6.39622729 -12.58779062 8.42E-13 25.52270086 SERPINB9P1 201417_at -0.701450369 9.852361371 -11.13916312 1.69E-11 21.7052266 SOX4 203542_s_at -0.701763092 6.260384771 -7.012382436 3.39E-07 9.350743336 KLF9 200923_at -0.705658722 7.797159376 -4.276475601 0.00053639 0.689080663 LGALS3BP 227196_at -0.709274553 6.676595103 -9.145634321 1.45E-09 15.98901858 RHPN2 212268_at -0.715766467 9.028746791 -7.051616012 3.07E-07 9.476279722 SERPINB1 228855_at -0.719605915 7.060998817 -6.621818479 9.41E-07 8.097355398 NUDT7 219888_at -0.72120683 6.680799645 -9.611395389 4.65E-10 17.37150717 SPAG4 218816_at -0.721841139 6.238904615 -4.103379499 0.000834839 0.175639259 LRRC1 244552_at -0.724779796 6.919334751 -7.606248335 7.28E-08 11.24060059 ZNF788P 227860_at -0.726222739 7.967851201 -5.580725524 1.63E-05 4.750610838 CPXM1 205942_s_at -0.73076586 7.571543683 -5.37231488 2.85E-05 4.08607468 ACSM3 219584_at -0.735411707 8.893510352 -4.633741584 0.000208564 1.772594529 PLA1A 229390_at -0.744609399 7.849795427 -5.637920051 1.39E-05 4.933557992 CALHM6 36711_at -0.74609501 8.341569349 -4.789099145 0.000137771 2.252198005 MAFF 216557_x_at -0.75124115 11.13249268 -4.181750096 0.000686319 0.407071749 IGHA1//IGHD//IGHG1//IGHG3//IGHM//IGHV4-31 1552736_a_at -0.752026598 6.413807172 -5.233338208 4.17E-05 3.645161329 NETO1 204588_s_at -0.760757458 8.9859807 -8.160057487 1.74E-08 12.97752922 SLC7A7 223059_s_at -0.763161809 10.79489346 -16.49923574 4.34E-16 34.50237076 FAM107B 224499_s_at -0.789208301 9.789671004 -5.206757593 4.50E-05 3.56106981 AICDA 209732_at -0.800771419 8.989879056 -8.569686885 6.02E-09 14.24258475 CLEC2B 1568593_a_at -0.804904715 6.868093592 -5.829135152 8.33E-06 5.546589518 NUDT16L2P 220603_s_at -0.811438393 7.737996959 -13.08445458 3.64E-13 26.76720901 MCTP2 212183_at -0.81513171 9.124308479 -9.895214583 2.26E-10 18.20022946 NUDT4//NUDT4B 211637_x_at -0.816865756 11.55418358 -4.772421266 0.000144029 2.200497935 IGH//IGHA1//IGHA2//IGHD//IGHG1//IGHG3//IGHG4//IGHM//IGHV4-31//IGHV3-23 209651_at -0.818918086 5.397417475 -5.18342064 4.78E-05 3.487307692 TGFB1I1 204348_s_at -0.824925291 9.251515766 -6.799646001 5.97E-07 8.668766458 AK4 217127_at -0.825855645 8.410521351 -4.714121584 0.000168202 2.020168677 CTH 217504_at -0.831065008 6.846578201 -7.398495195 1.22E-07 10.582228 ABCA6 206761_at -0.835031963 5.898906314 -5.376347142 2.82E-05 4.098896332 CD96 231310_at -0.835637375 6.230192802 -5.357460227 2.97E-05 4.038853725 TRIM71 228152_s_at -0.846958581 7.908444509 -5.91803457 6.55E-06 5.832180603 DDX60L 202912_at -0.8503782 6.426826756 -4.462038762 0.000327137 1.248190613 ADM 203892_at -0.859329752 7.101125458 -8.688147144 4.68E-09 14.60497686 WFDC2 214916_x_at -0.861091321 12.74998533 -4.376404515 0.000411888 0.989123415 IGK//IGHA1//IGHA2//IGHG1//IGHG3//IGHM//IGHV4-31//IGHV3-23 221530_s_at -0.868226478 6.568755523 -5.019079416 7.38E-05 2.969806095 BHLHE41 217198_x_at -0.869560824 6.871249553 -9.606468488 4.65E-10 17.35702822 IGH//IGHA2//IGHD//IGHG1 204897_at -0.871306515 7.043695541 -8.238865934 1.41E-08 13.22229856 PTGER4 223062_s_at -0.873978458 10.85204492 -6.324589041 2.13E-06 7.140666883 PSAT1 227915_at -0.875284197 8.042458039 -5.184242551 4.77E-05 3.489904445 ASB2 229116_at -0.877736783 5.96538896 -6.053148995 4.50E-06 6.266731684 CNKSR2 207030_s_at -0.882412278 6.034985678 -6.168673646 3.27E-06 6.638593181 CSRP2 1552390_a_at -0.903363225 7.85940319 -4.806645106 0.000131954 2.306641895 ERICH5 205554_s_at -0.903371883 6.278062011 -10.03211085 1.63E-10 18.59615558 DNASE1L3 209995_s_at -0.907057279 11.60130827 -6.607392115 9.80E-07 8.050958269 TCL1A 220132_s_at -0.908558249 11.17878372 -9.5125933 5.81E-10 17.08055212 CLEC2D 201123_s_at -0.913929906 11.90890079 -4.272320979 0.000541662 0.676661504 EIF5A 228293_at -0.918866807 5.582354191 -6.101613369 3.95E-06 6.422707299 DEPDC7 227481_at -0.922703465 6.269803002 -6.307489002 2.24E-06 7.085599506 CNKSR3 202600_s_at -0.924723811 7.449814346 -6.236827166 2.70E-06 6.858046922 NRIP1 228739_at -0.926716816 8.074975514 -5.004524819 7.66E-05 2.924150218 CYS1 205159_at -0.941597231 7.325933462 -6.692643318 7.92E-07 8.325055733 CSF2RB 215379_x_at -0.944546258 13.98912039 -4.542922804 0.00026569 1.494432088 IGLV@//IGLV1-44 215121_x_at -0.946838497 14.30615596 -4.52305279 0.000279358 1.43380626 IGLC1//IGLV1-44//CYAT1 235278_at -0.955754677 9.897781904 -6.243406977 2.65E-06 6.879235415 MACROD2 226022_at -0.964141784 7.236410446 -5.967410963 5.71E-06 5.990924099 SASH1 225600_at -0.970999571 7.125139432 -12.19799304 1.51E-12 24.52321758 TRIQK 204984_at -0.976245694 5.680886638 -6.248079035 2.63E-06 6.894280615 GPC4 203305_at -0.987692302 8.481761408 -6.552952336 1.13E-06 7.875828041 F13A1 219836_at -0.990232031 6.551176092 -5.183633804 4.78E-05 3.487981155 ZBED2 212314_at -0.991650046 10.21814563 -6.190921256 3.08E-06 6.710226276 SEL1L3 203939_at -0.996623614 6.90935963 -6.198708503 3.01E-06 6.735300787 NT5E 225792_at -0.998817574 8.198463052 -6.099242729 3.97E-06 6.415076743 HOOK1 33767_at -1.021514142 6.548973329 -6.276837638 2.44E-06 6.986891934 NEFH 211908_x_at -1.023865782 10.38467328 -4.599250402 0.000229386 1.666752489 IGK 203574_at -1.029085673 6.885047378 -7.782817588 4.64E-08 11.79740862 NFIL3 218532_s_at -1.039797286 5.872073585 -5.032090655 7.14E-05 3.010646135 RETREG1 219670_at -1.045663083 5.955518937 -8.595737139 5.72E-09 14.32241435 BEND5 206700_s_at -1.067392373 6.647205176 -4.37632212 0.000411888 0.988874989 KDM5D 210587_at -1.08085665 4.461770704 -4.047581516 0.000962048 0.011958971 INHBE 230425_at -1.083776797 7.618233328 -5.327501655 3.23E-05 3.943684857 EPHB1 217281_x_at -1.084796286 11.18816105 -4.624883415 0.000213705 1.745388703 IGH//IGHA1//IGHA2//IGHG1//IGHG2//IGHG3//IGHM//IGHV4-31 209138_x_at -1.087387385 14.26338035 -4.577483028 0.000242361 1.600081419 IGLC1 209374_s_at -1.094860205 13.96430643 -4.894450069 0.000104202 2.579879718 IGHM 217227_x_at -1.097260818 9.523295477 -4.197841802 0.000658206 0.45480641 IGLV1-44 229147_at -1.110689271 8.356299159 -7.567116241 8.12E-08 11.11684684 RASSF6 203038_at -1.122748718 6.862939065 -4.171647634 0.000703405 0.377140537 PTPRK 214953_s_at -1.136191353 8.402160548 -6.925730831 4.24E-07 9.073208099 APP 214677_x_at -1.144581281 14.27085563 -4.69784659 0.000175512 1.969940357 IGLJ3//IGLC1 215176_x_at -1.144752856 13.27771881 -6.676709652 8.27E-07 8.273841914 IGKC//IGK 238332_at -1.145040036 6.396182789 -5.722162044 1.10E-05 5.203394568 ANKRD29 217235_x_at -1.15115667 11.85041937 -5.27855686 3.70E-05 3.788398584 IGLV@//IGLL5 215621_s_at -1.180414267 9.31895178 -8.47464108 7.83E-09 13.95067661 IGK//IGHD 207651_at -1.18427199 5.997906193 -5.625606981 1.43E-05 4.894154085 GPR171 236981_at -1.195921642 6.360517755 -11.17040554 1.61E-11 21.79055334 C17orf99 203325_s_at -1.208130496 7.322653046 -6.791233075 6.05E-07 8.641757418 COL5A1 214973_x_at -1.223270154 10.51263973 -4.245710982 0.000582391 0.597225829 IGHD 202859_x_at -1.233141461 6.618762867 -7.151238101 2.35E-07 9.794663855 CXCL8 44790_s_at -1.244291523 9.12298637 -4.642029966 0.000203914 1.798064642 RUBCNL 216510_x_at -1.247174112 11.13578899 -5.273792223 3.74E-05 3.773295337 IGHA1//IGHG1//IGHM//IGHV4-31//IGHV3-23 206545_at -1.267041914 5.265623703 -6.98860504 3.62E-07 9.274623727 CD28 217028_at -1.297680808 8.976517497 -8.619683729 5.51E-09 14.39572956 CXCR4 1559280_a_at -1.298115514 7.41452369 -5.154628127 5.14E-05 3.396391692 APELA 216984_x_at -1.303674764 12.37844831 -5.926521652 6.41E-06 5.859460714 IGLJ3//IGLC1//IGLV@//CKAP2//IGLV1-44 228636_at -1.304105275 8.836355776 -6.554445894 1.12E-06 7.880633624 BHLHE22 231897_at -1.322186161 7.154451193 -7.340483408 1.43E-07 10.39781557 PTGR1 205001_s_at -1.365560586 6.674397743 -6.158298875 3.38E-06 6.605190105 DDX3Y 221045_s_at -1.370608756 6.248497542 -7.996693353 2.65E-08 12.46814819 PER3 224837_at -1.372398093 7.354275496 -7.35482963 1.39E-07 10.44344248 FOXP1 213674_x_at -1.393579174 10.11168574 -8.345917045 1.11E-08 13.55374913 IGHG1//IGHD 228496_s_at -1.402531545 8.023032094 -6.410126872 1.67E-06 7.416104265 CRIM1 223939_at -1.408227323 7.164813835 -5.023667498 7.29E-05 2.984204566 SUCNR1 203408_s_at -1.458797014 5.222803844 -8.64041618 5.23E-09 14.4591516 SATB1 230896_at -1.480085549 8.680762525 -6.258153191 2.55E-06 6.926722183 BEND4 228492_at -1.493868344 5.253123714 -6.525432333 1.21E-06 7.787273327 USP9Y 214777_at -1.507640489 11.41951005 -4.685859589 0.000180808 1.932977945 IGKC 217148_x_at -1.530504398 12.68124403 -5.292863662 3.55E-05 3.833763715 IGLC1//IGLV@//IGLJ3 201540_at -1.605592999 6.174618345 -6.973063909 3.78E-07 9.224855946 FHL1 209487_at -1.64645038 6.863262788 -6.65931728 8.58E-07 8.217930952 RBPMS 236694_at -1.710161897 6.180204322 -6.378438895 1.82E-06 7.314072584 TXLNGY 201215_at -1.807464019 6.310382264 -6.920734695 4.30E-07 9.057195121 PLS3 211430_s_at -1.913179282 12.92485601 -4.890854517 0.000105038 2.568665895 IGHG3//IGHG1//IGHG2//IGHM//IGHV4-31//MIR8071-1//MIR8071-2 234764_x_at -2.121717549 10.86029107 -6.114704158 3.82E-06 6.464845232 IGLV1-44//IGLC1//IGLV@//CKAP2//IGLJ3 201909_at -2.278656475 9.086850919 -5.822652273 8.49E-06 5.525775598 RPS4Y1 204409_s_at -2.392604468 6.357792914 -5.930438465 6.35E-06 5.872051375 EIF1AY