#NEXUS [ TITLE ] BEGIN TAXA; DIMENSIONS NTAX=97; TAXLABELS cod_GSDM_Eb cod_pjvk TRICHO_GD huGSDM_A huGSDM_B huGSDM_C huGSDM_D huGSDM_E huPJVK moGSDM_D moGSDM_C moGSDM_A2 moGSDM_E moGSDM_A moGSDM_C4 moGSDM_A3 moGSDM_C3 moGSDM_C2 moPJVK cow_gsdmA cow_gsdmB cow_gsdmC cow_gsdmD cow_gsdmE cow_pjvk_(e1bk64) pigGSDM_D pigGSDM_A pigGSDM_C pigGSDM_B pigGSDM_E pig_pjvk go_GSDMA Go_GSDMB Go_GSDMC Go_GSDMD Go_GSDME Go_pjvk orca_gsdmC orca_gsdmB orca_pvjk orca_gsdmE orca_gsdmD seal_ga2 seal_ga1 seal_gsdmB seal_pjvk seal_gsdmD_( seal_gsdme Flyca_gsdme fice_PJVK flyca_gsdmA turkey_gE turkey_GA2 TURKEY_PJVK chGSDM_A chGSDM_E ch_PJVK lizard_gE lizard_gA1 lizard_pjvk turtle_GA turtle_GE turtle_PJVK frog_pjvk frogGSDM_E Lamp2p_ medaka_GEa medaka_gEb medaka_pjvk tetra_GEa tetra_GEb tetrA_PJVK coe_GE coe_pjvk zfGSDM_Eb zfGSDM_Ea_(E7F9U2) zfPJVK Fugu_GEa Fugu_GEb fugu_PJVK tila_gb tila_pjvk shark_ge shark_pjvk lance_pjvk NEMA_PJVK STYLO_PJVK EXAIP_PJVK ORBI_PJVK ACRO_PJVK HYDRA_PJVK LINGU_PJVK SACCO_PJVK LOTT_JVK POMA_PJVK OCTO_PJVK STRONG_PJVK ; END; BEGIN CHARACTERS; DIMENSIONS NCHAR=679; FORMAT MISSING=? GAP=- MATCHCHAR=. datatype=protein; MATRIX cod_GSDM_Eb ------------MFATATKNFVEEV--DKDGVLIPVSSLNDS--IKILSLVIKRRRYWFWQKPKYLA--TDFCFNDIL-KGDQ-----PILPVLTETDFIK------YNGRFSDNMQGNIE--ANLH--SANLSVEGKDSSKLRSAFGSLKKEE-LDLQ------------RVLDMSHSLIQQTKEKRREVFGVVKERIVTTQPSSVIEEVQQTGALGGLLSLCG--------PKVSFKENANLAKDSNVTMELPPHTTIAYGLS----------ELEVKPNGHYELCLMSGTHGGFEVDGSSEEQLVG-----------------------------------------------------------AFYCSAELDKLGSHFQLLS-----------------------------GLKASTRSSLFQYVCS--VLKERGAVSLLESVLNQIRHG-ERPPL-DSGQ----ADSQTQTVQALLEVLV------------------------------------------------LSGE---EDFSCTLLALHLVISALD-------------------------VQCVTEAGEMSLSSGDLAPLTGD-TYQRTELLFASCGVSLKRD-GGGQRSSASSRP---TLILCIVVKGLAAIS--------------------- cod_pjvk -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MREQLGGFLGRFSMGR-----------------------------LRRFLSGIVYGNPFRA--DDRAFEGLTYPEPYMDDGATD---------------DYEKAASMTDLSSAY-------------------------------------------------------------LREGSHTRINLLNHNIAKGPCSLCGMGSQRRETVYGCLECSSGGQKYVRLHVVPCFDLWHKTLR--------------------------------------------------------------------- TRICHO_GD ------------MFAVAVNEFIRSA---GQDSLCGVPDINSSGDFMPLHIIVKEVPKVLPCCRRPKIKRTPYTLNDILDEPCP--------NQLKSSDLVT------FTEPLVSNVKASSS-IGLQILKHFDSGAKGSKNFITSASLGTVVKAETIDITKVLAKVRTAK----AKVENDLVSRVMKTKRLCLGLVVETACVAAAGKLTEADNWEISGHTNANIGEAVVT----------ATAELDKNLSRKIEIPPGTALAYSFM----------DLEILEDRSLRVSSSAGAMFDSGKAESTV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- huGSDM_A ----------MTMFENVTRALARQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYVRTDYTLLDVLEPGSS------PSDPTDTGN-------FGFKNMLDTRVEG--DV-DVPKTVKVKGTAGLSQNS--TLEVQTLSVAP-KALETVQ-ERKLA--------ADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQG-------------SINHKE--AVTIPKGCVLAFRVR----------QLMVKGKDEWDIPHICND---NMQTFPPGEKSGEEKVILIQASDV-------------------------------------------------GDVHEGFRTLKEEVQRETQQVE-------------------------KLSRVGQSSLLSSLSK--LLGKKKELQDLELALEGALDKG-----------------HEVTLEALP-KDVLL-------------------------------------------------------SKEAVGAILYFVGALTELSEAQ-QKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMWD--PDTLPRLCALYAGLSLLQQLTKAS------------ huGSDM_B ---------MFSVFEEITRIVVKEM--DAGGDMIAVRSLVDADRFRCFHLVGEKRT-----FFGCRHYTTGLTLMDILD-TDGDKWLDELDSGLQGQK-------AEFQILDNVDSTGELIV-RLPKEITISGSFQGFH--HQKIKISENRISQ-QYLATLENRKLKR--------ELPFSFRSIN-TRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHL------------------SYKHKGQREVTIPPNRVLSYRVK----------QLVFPNKETMR----------------------------------------------------------------------------------KSLGSEDSRNMKEKLEDMESVLK-------------------------DLTEEKRKDVLNSLAK--CLGKEDIRQDLEQRVSEVLISGELHME----------DPDKPLLSSLFNAAGVL-------------------------------------------------------VEARAKAILDFLDALLELSEEQ-QFVAEALEKGTLPLLKDQVK-SVMEQN----------------------------------WDELASSPPDMDYD--PEAR-ILCALYVVVSILLELAEGPTSVSS------- huGSDM_C ---------MPSMLERISKNLVKEI---GSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFSLNDILEPSSS------VLETVVTGP-------FHFSDIMIQKHKADMGV-NVGIEVSVSGEASVDHGC--SLEFQIVTIPS-PNLEDFQKRKLLD--------PEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILGKIAL-WITYGKGQ---------GQGESLRVKKKALTLQKGMVMAYKRK----------QLVIKEK---AILISDDDEQRTFQDEYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLA-------------------------QLSKDVQDVMFYSILA--MLRDRGALQDLMNMLELDSSGHLD-------------GPGGAILKKLQQDSNHA-------------------------------------------------------WFNPKDPILYLLEAIMVLSDFQ-HDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNPRSTWD--VEAKMPLSALYGTLSLLQQLAEA------------- huGSDM_D ---------MGSAFERVVRRVVQEL--DHGGEFIPVTSLQSSTGFQPYCLVVRKPS--SSWFWKPRYKCVNLSIKDILEPDAA------EPDVQRGRS-------FHFYDAMDGQIQGSVEL-AAPGQAKIAGGAAVSDSSSTSMNVYSLSVDP-NTWQTLLHERHLRQ-------PEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGE---------GQGHLSQKK--TVTIPSGSTLAFRVA----------QLVID--SDLDVLLFPDK---KQRTFQPPATGHKRSTSEGAWP----QLPSGLSMMRCLHNFLTDG------------------------VPAEGAFTEDFQGLRAEVETISKELE-------------------------LLDRELCQLLLEGLEG--VLRDQLALRALEEALEQGQSLG-PVEPL--D------GPAGAVLECLVLSSGML-------------------------------------------------------VPELAIPVVYLLGALTMLSETQ-HKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEG-APAWVLLDECGLELGEDTPHVCWE--PQAQGRMCALYASLALLSGLSQEPH----------- huGSDM_E ------------MFAKATRNFLREV--DADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQF--LSLTLGDVL-IEDQ-----FPSPVVVESDFVK------YEGKFANHVSGTLE--TALG--KVKLNLGGSSRVESQSSFGTLRKQE-VDLQQLIRDSAER----TINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVISEHMQVEEKCGGIVGIQTKT------VQVSATEDGNVTKDSNVVLEIPAATTIAYGVI----------ELYVKLDGQFEFCLLRGKQGGFE-NKKRIDSVYLDPLVFREFAFIDMPDAA---------------------------------HGISSQDGPLSVLKQATLLLERNFHPFA-----------------------------ELPEPQQTALSDIFQA--VLFDDELLMVLEPVCDDLVSG-LSPTVAVLG---ELKPRQQQDLVAFLQLVGCS-----------------------------------------LQGGCPGPEDA-GSKQ-LFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVSDLEDPTLTPLKDTERFGIVQRLFASADISLERL-KSSVKAVILKDSKVFPLLLCITLNGLCALGREHS----------------- huPJVK ------------MFAAATKSFVKQV--GDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTS--TPFTLKDIL-LGDR-----EISAGISSYQLLN------YEDESDVSLYGRR---GNHIVNDVGINVAGSDSIAVKASFGIVTKHE-VEVSTLLKEITTR----KINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSV----------HAGIRGEA-------MRFHFMDEQNPKGRDKAIVFPAHTTIAFSVF----------ELFIYLDGAFDLCVTSVSKGGFEREE------------------------------------------------------------------------------TATFAL-------------------------------LYRLR-----NILFER--NRRVMDVISRSQLYLDDLFSD---------------YYDKPLSMTDIS----------------------------------------------------------------LKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK--------------------------------------------------------------------- moGSDM_D ---------MPSAFEKVVKNVIKEVS-GSRGDLIPVDSLRNSTSFRPYCLLNRKFS--SSRFWKPRYSCVNLSIKDILEPSAP------EPEPECFGS-------FKVSDVVDGNIQGRVML-SGMGEGKISGGAAVSDSSSASMNVCILRVTQ-KTWETMQHERHLQQ-------PENKILQQLRSRGDDLFVVTEVLQTKEEVQITEVHSQEGSGQFTLPGALCLKGE---------GKGHQSRKK--MVTIPAGSILAFRVA----------QLLIG--SKWDILLVSDE---KQRTFEP-SSGDRKAVGQRHHG---LNVLAALCSIGKQLSLLSDGI-----------------------DEEELIEAADFQGLYAEVKACSSELE-------------------------SLEMELRQQILVNIGK--ILQDQPSMEALEASLGQGLCSGGQVEPL--D------GPAGCILECLVLDSGEL-------------------------------------------------------VPELAAPIFYLLGALAVLSETQ-QQLLAKALETTVLSKQLELVKHVLEQSTPWQEQSSVSLPTVLLGDCWDEK-NPTWVLLEECGLRLQVESPQVHWE--PTSLIPTSALYASLFLLSSLGQKPC----------- moGSDM_C ---------MSYTFDWLSKDVVKKL---QGRDLRPVKCLSDATKFCLFNILQETSS--RLALKTEY-IPVGFTLLHLLEPNIP------VPEPEVSAP-------IPLKHTISQKLKADLDV-ETIAGGEAG--FVKSCGY--DIEVQSKSIPN-PKLESLQNRKLLD--------QLPTFMKTCWKDGKNLYVVTEAYEVTKDTVLEGTSNSKFAIKGIINQLVKVGGS---------GQWQ--TEKTDSIPIQKGSVLAYKKQ----------QLVIEDNTCVILTSANTKKKMTFP---MRFVGMSGHLRYQDLVI--------------ETGSWIND--------------------IDPIGTIKEPTHLDFMCLQNEVSEQTRLLA-------------------------ELSKDVQEVVFSSFLHMLC--DRDVLYDLMKMLELNQLGHMD-------------GPGGKILDELRKDSSLS-------------------------------------------------------WINLKDLILYLLQALMVLSDTQ-LCLLALSVEMRLLPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWD--LEAKMPLSALYGSLSFLQQLSEA------------- moGSDM_A2 ----------MSMFEDVTRALARQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYVRTDYTLLDVLEPGSS------PSDPTLLGN-------FSFKNMLDVRVEG--DV-EVPTMMKVKGTVGLSQSS--TLEVQMLSVAP-TALENLHMERKLS--------ADHPFLKEMREYKQNLYVVMEVVKAKQEVTLKRASNAISKFSLN-LPSLGLQG-------------SVNHKE--AVTIPKGCVLAYRVR----------QLIIYGKDEWGIPYICTD---NMPTFNPLCVLQRQG--STVQMIS-------------------------------------------------GEMHEDFKTLKKEVQQETQEVE-------------------------KLSPVGRSSLLTSLSH--LLGKKKELQDLEQMLEGALDKG-----------------HEVTLEALP-KDVLL-------------------------------------------------------LKDAMDAILYFLGALTELSEEQ-LKILVKSLENKVLPVQLKLVESILEQNFLQDKEDVFPLRPDLLSSLGEEDQILTEALVGLSGLEVQRSGPQYTWN--PDTCHNLCALYAGLSLLHLLSRDS------------ moGSDM_E ------------MFAKATRNFLKEV--DAGGDLISVSHLNDSDKLQLLSLVTKKKRYWCWQRPKYQI--LSATLEDVL-TEGH-----CLSPVVVESDFVK------YESKCENHKSGAIG--TVVG--KVKLNVGGKGVVESHSSFGTLRKQE-VDVQQLIQDAVKR----TVNMDNLVLQQVLESRNEVLCVLTQKIMTTQKCVISEHVQSEETCGGMVGIQTKT------IQVSATEDGTVTTDTNVVLEIPAATTIAYGIM----------ELFVKQDGQFEFCLLQGKHGGFE-HERKLDSVYLDPLAYREFAFLDMLDGG---------------------------------QGISSQDGPLRVVKQATLHLERSFHPFA-----------------------------VLPAQQQRALFCVLQK--ILFDEELLRALEQVCDDVAGG-LWSSQAVLAM-EELTDSQQQDLTAFLQLVGYR-----------------------------------------IQGEHPGPQDE-VSNQKLFATAYFLVSALAEMPDNATVFLGTCCKLHVISSLCCLLHALSDDSVCDFHNPTLAPLRDTERFGIVQRLFASADIALERM-QFSAKATILKDSCIFPLILHITLSGLSTLSKEHEEELCQSGHATGQD---- moGSDM_A ----------MTMFENVTRALARQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYVHTDYTLLDVLEPGSS------PSDPTDSGN-------FSFKNMLDARVEG--DV-DVPKTVKVKGTAGLSRSS--TLEVQTLSVAP-TALENLHKERKLS--------ADHPFLKEMRERGENLYVVMEVVETLQEVTLERAGKAEGCFSLPFFAPLGLQG-------------SVNHKE--AVTIPKGCVLAYRVR----------QLMVNGKDEWGIPHICND---SMQTFPPGEKPGEGKFILIQASDV-------------------------------------------------GEMHEDFKTLKEEVQRETQEVE-------------------------KLSPVGRSSLLTSLSH--LLGKKKELQDLEQTLEGALDKG-----------------HEVTLEALP-KDVLL-------------------------------------------------------SKDAMDAILYFLGALTVLSEAQ-QKLLVKSLEKKILPVQLKLVESTMEKNFLQDKEGVFPLQPDLLSSLGEEELILTEALVGLSGLEVQRSGPQYTWD--PDTLPHLCALYAGLSLLQLLSKNS------------ moGSDM_C4 ---------MGYSFDRASKDVVKKL---QGRDLRPVECLSDATKFRLFHILQETP---RSGWETED-IPVGFTLLDLLEPNFP------VPEPEVSAP-------KPFIHVQSTDLEANLNV-ADIARGGVG--YVGYGGY--NIEVQSTSIPN-PKLEILQNRKLLD--------KLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQLFKVRG----------KAGR--SEK-YSIPIPKGSVLAYKKQ----------QLVIENNTCVILPSA-TKKKMTFPDRPLKLYDLPVTLRYQEEVI--------------ETGSWIDD--------------------IDPIGTIEEPANLNFMCLQHEVSEQTQLLA-------------------------ELSKDVQEVVFSSFLHMLS--DRDVLYDLMKMLELNQLGHMD-------------GPGGKILDELRKDSSTP-------------------------------------------------------HDVLKDLNLYLLQALLVLSDTQ-LCLLAQSVKMGLLPHQVELVKSILQTNFKYSSNTPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWD--LEAKMPLSALYGSLSFLQQLQKANSSSKPSLSPGYI moGSDM_A3 ----------MPVFEDVTRALVREL--NPRGDLTPLDSLIDFKHFRPFCLVLRKRK--STLFWGARYVRTDYTLLDLLEPGSS------PSDLTDSGN-------FSFKNMLDVQVQG--LV-EVPKTVKVKGTAGLSQSS--TLEVQTLSVAP-SALENLKKERKLS--------ADHSFLNEMRYHEKNLYVVMEAVEAKQEVTVEQTGNANAIFSLPSLALLGLQG-------------SLNNNK--AVTIPKGCVLAYRVR----------LLRVFLFNLWDIPYICND---SMQTFPKIRRVPCSAFISPTQMISE-----------------EPEE-----------------------EKLIGEMHEDFKTLKEEVQRETQEVE-------------------------KLSPVGRSSLLTSLSH--LLGKKKELQDLEQKLEGALDKG-----------------QKVTLEALP-KDVLL-------------------------------------------------------SKDAMDAILYFLGALTELTEEQ-LKILVKSLEKKILPVQLKLVESTLEQNFLQDKEGVFPLQPDLLSSLGEEELTLTEALVGLSGLEVQRSGPQYAWD--PDTRHNLCALYAGLSLLHLLSRKSNALTYCALS--- moGSDM_C3 ---------MGYSFDRASKDVVKKL---QGRDLRPVECLSDATKFRLFHILQETP---RSGWETED-IPVGFTLLDLLEPNFP------VPEPEVSAP-------KPFIHVQSTDLEANLNV-ADIARGGVG--YVGYGGY--NIEVQSTSIPN-PKLEILQNRKLLD--------KLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQLFKVRG----------KAGR--SEK-YSIPIPKGSVLAYKKQ----------QLVIENNTCVILPSA-TKKKMTFPGTPKYASASEPTEIYRTEL----------------QGLWIND--------------------IEPIGRIQEPAHLDFKCLQYEVSEQTRLLP-------------------------ELSKDVQEVVLSSFLSMLYEGDRNVLHDLMKMLELSQLGHMD-------------GPGGKILDELRKDSSNP-------------------------------------------------------CVDLKDLILYLLQALMVLSDSQ-LNLLARSVEMRLLPHQVELVTSILQPNFKYPWNIPFTVQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWD--LEAKMPLSALYGSLSFLQQLQKANSSFKPSLRPGYI moGSDM_C2 ---------MGYSFDRASKDVVKKL---QGRDLRPVECLSDATKFRLFHILQETP---RSGWETED-IPVGFTLLDLLEPNFP------VPEPEVSAP-------KPFIHVQSTDLEANLNV-ADIARGGVG--YVGYGGY--NIEVQSTSIPN-PKLEILQNRKLLD--------NLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLSVKGFFKQLFKVRG----------KAGR--SEK-YSIPIPKGSVLAYKKQ----------QLVIENNTCVILPSA-TKKKMTFPGTPKYASASEPTEIYRTEL----------------QGLWIND--------------------IVPIGRIQEPAHLDFMCLQNEVYKQTEQLA-------------------------ELSKGVQEVVLSSILSMLYEGDRKVLYDLMNMLELNQLGHMD-------------GPGGKILDELRKDSSNP-------------------------------------------------------CVDLKDLILYLLQALMVLSDSQ-LNLLAQSVEMGILPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWD--LEAKMPLSALYGSLSFLQQLRKANSSSKPSLRPGYI moPJVK ------------MFAAATKSFVKQV--GDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRCKFTS--TPFTLKDIL-LGDR-----EISAGISSYQLLN------YEDESDVSLYGRR---SNHIVNDVGINVTGSDSIAVKASFGVVTKHE-VEVSTLLKEITAR----KINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSV----------HAGIRGEA-------MRFHFMDEQNPKGREKAIVFPAHTTIAFSVF----------ELFIYLDGAFDICVTSVSKGGFEREE------------------------------------------------------------------------------TTTFAM-------------------------------FYRLR-----NILFER--NRRVMDAISRSQLYLDDLFSD---------------FYDKPLSMTDIS----------------------------------------------------------------LKEGTHIRVNLLNHNIPKGPCILCGMGNLKRETVYGCFQCSVDGVKYVRLHAVPCFDIWHKRMK--------------------------------------------------------------------- cow_gsdmA ----------MTMFENVTRALTRQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYVCTDYTFLDILEPGSS------PSDPTDSGN-------FGFKNMLDARVEG--EV-DVPKTVKVKGTAGLSRNS--TLEVQTLSVAP-KALETLHQERKLM--------AEHPFLEEMRRRGENLYVVMEVVEAVQEVTLERAGRAEGCFSLPFFASLGLQG-------------SVNHKE--AVTIPKGCVLAFRVR----------QLMVKGKDEWDIPHIYND---NMHTFPPGEKPEDEKFTLIQASDV-------------------------------------------------GAVHEDFRTLKEEVQRETQEVE-------------------------KLSPEGKSSLLSSLSK--LLGKKKELQDLELTLEEALGKG-----------------HEETLEALP-KNVLL-------------------------------------------------------SKGAMDAILYFLGALAELSEAQ-QKLLVKSMEKKILPVQLKLVESTMEQNFLQDKEGVFPLRPELLSSLGEEELTLTEALVGLSGLEVQRSGPQYTWD--PDTLPRLCALYAGLSLLQLLTKAS------------ cow_gsdmB ---------MPTVFESISRAVVKEI--DTSGETIAVRSLSDADKFHCSYLVKKRRR-----FFGYQYDKTNLTLKDILECEVP---FDMVVPELQGQG-------DNFEILDVVDSKGSLAV-KFHPQMTFKIAFHIFQ--EKNIKLEKSEIPQ-EFLDSLKNKKLKK--------ELPPSFQSIQAKREDLYLVTETLKTKRTETLKYETQFGFQILLKMFGF------------------QCKHKHQKEVTITPEKVLAYRVK----------QLVFPSAERMDICFLDKTRSFPE---------------------------------------------------------------------GKSLNLQNFRSIKETVQDMVRVLQ-------------------------DLTPEEQKEALNCFTK--CLSSEEELQDLEQRVSEVQCSGELQMN----------SPANSLISSLFNAAGVL-------------------------------------------------------IEARAETIWDVLDALMELSEYR-QFVAEVLDKGELRPVK-DKVESILEEN----------------------------------RCE---GPLDVSCD--PEAR-TLCALYVVVSILLQLSEKPTSVSS------- cow_gsdmC ---------MPSLFEHTSKNLVKEL---GDKDFRPLQNLLSAHKFCQLKLLRKKRRTLSQFWEQPD-VPVDHTLTDILEPSPS------VPEPVLSKK-------FIFIDKTVWKGAAEVDV-TAGLEVSVSGTATQSCEC--SLEVQSVTISP-WDWEDLQKRKVLD--------QEPSFLQECRTRGDNLYVVTEAVKLVNETVLQDSSSVNATGTFSIPWSFYAKST---------AEGSGLKERKRTMTVPQGTVMAYKKK----------QLVFREDGRAILLISDDDKQKTFPEIKLQGLPLSPEILSISDDNKRKAFFVGKVQRQSAMGTKRRP--------------------ILPIGRIQEPISRDFKSLQNEVSREIEAVA-------------------------ELPRDIRDALFHTILA--KLKDQGALQDLTDMLDGNLWDHT-----------------GSFLSEMREDSRNV-------------------------------------------------------WLESRPCVIYLLEALLVLSDIQ-HELLAWSMEKRILPQQRELVESILEPNFRYPWNIPFTLDPKLLASLQDEGLAVTFGLLQECGLRVAPDNPKGTWD--LEAKKPLSALYGSLSVLQQLAEA------------- cow_gsdmD ---------MASAFEKVVRSVVREL--DHK-DLTPVDSLWSSTSFQPYTLLSRKPL--SSRFWRPRYKCVNLSIRDILEPDAP------EPALECGRT-------FQFHDAMDGQLQGSVKL-AAPGQGRLSGGAAVSGSSSASMDLCTLRVTP-NTWEAMHHERRLRQ-------PEPKTLQQLRSRGDDVFVVTEVLQTQKEVEVTRTHKQEGSGQFALPGAFCLQGK---------GEGHLSQKK--TVTIPSGSTLAFRAA----------QLVIG--SDWDILLFPDK---KQRTFLSLQAGRRPSSSADSHPHPCFSLAS-IRALSDYFHFQPDGS-----------------------TEHWLATTDDYQGLRAEVKAWAMGLE-------------------------GLSKGLCGQLLGGLGQ--VLRDEPALQALEDSLEQGLCSG-PVEPR--D------GPVGAILESLVLPSGQL-------------------------------------------------------ETELAGPVFYLLQALAVLSEAQ-HVLLAEVLEMGALSGTFWLVESLVEQSSPWQEHRAVSLPPERLGDSWGSE-APGWALLEACGLEPQVGTPQVCWE--PGARGCACALYACLALLLRLSQLC------------ cow_gsdmE ------------MFAKATRNFLKEV--DAGGNLIAVSNLNDSDKLQLLSLVTKKKRYWCWQRPKYQF--LSVTLGDVL-TEDQ-----FLSPVVVESDFVK------YEGKFENHVSGTLE--TALG--KVKLNIGGKGLVESQSSFGTLRKQE-VDLQQLIGDAQER----TINLKNPVLQQVLERKNAVLCVLTQKIVTTQKCVISEHVQIEETCGGMVGIQTRT------VQVSAMEDGNIIKDTNVVLEIPAPTTIAYGVI----------ELYVRADGQFEFCLLQGKHGGFE-QERRSNSVLLDPLPFREFVFWDMPDAG---------------------------------QGLPAQDKPLSVLKQATLLLERNFHPFM-----------------------------ELPEQQQIALNDVLQA--VLLDEELLVVLEQVCDDIVSS-LSPSLVALG---ELKPSQKHNLTTFLRLVGCS-----------------------------------------VQGERLGSQDV-VDNQKLFSTAFFLVSALAEMPDNAAALLGTCCKLQIIPLLYHLLRALSHDGVSDLEDPALAPLKDREKFGIVQRLFAATDINLERM-QSSVKAASREDPNVLPLILYISLSGLCALGRAQ------------------ cow_pjvk_(e1bk64) ------------MFAAATKSFVKQV--GDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTS--TPFTLKDIL-LGNR-----EISAGISSYQLLN------YEDESDVSLYGRR---GNHIVSDVGINVTGSDSIAVKASFGVVTKHE-VEVSTLLKEITTR----KINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSV----------HAGIRGEA-------MRFHFMDEQNPKGRDKAIVFPAHTTIAFSVF----------ELFIYLDGAFDLCVTSVSKGGFEREE------------------------------------------------------------------------------TATFAL-------------------------------LYRLR-----NILFER--NRRVMDAISRSQLYLDDLFSD---------------YYDKPLSMSDIS----------------------------------------------------------------LKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK--------------------------------------------------------------------- pigGSDM_D ---------MASAFERVVKSVVREL--DHGRELTPVKSLQTSDRFQPYCLLGRKPS--SSWFWRPRYTCVDLSIWDILEPSAP------EPAVERGGP-------FYFHDTMDGQLQGQVEL-AAPGQGKFSGGAAVSGSSSASMNVCTLRVAP-NTWDAMHLERRLRQ-------PEHKVLQQLRSRGNDVFVVTEVLQTQKEVEVTRTHKQEGSGQFALPGAVSLQGQ---------GQGHLSRKK--TVTIPSGSVIAFRVA----------QLVIG--SDWDILLFPDK---KQRTFRPLREGHSASHGADGQPPQFSRLVSGMSFPSEHLKFQSDGP-----------------------AEDQLVTTEDFQGLQAEVDAWAAGLE-------------------------ALSREPCRQLLGGLGQ--VLQDEPALQALEDSLEQGLCGG-LVEPQ--D------GPAGAMLECLVLACRRL-------------------------------------------------------EREVAGPIFYLVQALAVLNETQ-HVLLAKVLETGALSGALTLVGSLLEQSAPWQERRAVSLPPTLLGSSWGSE-APIWALLEECGLEPQVGTAQVCWE--PEAQSCTCALYACLALLLRLSQLC------------ pigGSDM_A ----------MTMFENVTRALARQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYIRTDYTLLDVLEPGSS------PSDPTDSGN-------FGFKNMLDARVEG--EV-DVPKTVKVTGTAGLSQNS--TLEVQTLSVAP-KALETLHQERKLM--------AEHPFLKEMRSRGENLYVVMEVVETVQEVTLQRAGKAEGCFSLPFFAPLGLQG-------------SINHKE--AVTIPKGCILAFRVR----------QLVVKGRDEWDIPHICND---NMQTFPPG---------VIQASDV-------------------------------------------------GEVHEDFRTLKEEVERETQEVE-------------------------KLSPRGRSSLLCSLSK--LLGKKKELQDLELTLEGALDKG-----------------HEVTLEALP-KDVLP-------------------------------------------------------SKEAMGAVLYFLGALTELSEAQ-QKLLVKSMEKNILPVQLKLVESTMEQHFLQDKEGVFPLQPELLSSLGEEELTLTEALVGLSGLEVQRSGPQYTWD--PDTLPHLCALYAGLSLMQLLSKAS------------ pigGSDM_C ---------MASLFERVSKNLVKEL---GDKDLKPVKSPLDTNKFRQFALLRKKRKTRTEFWEKPD-VSAECSLMDILEPSSL------VPETVVTGP-------FHFKDKVIAMESVHMDV-TAGLEVSVLGEAAQSHGS--SLEFRSVAIPP-TTWEGLQKRKVLE--------KK---LVKYRDAGQNLYVVTEAVELINGTVLQDKSSITALGKFLLPWTTYVQSK---------VEGG--RVRDTTLMLPSGTVMAYKKK----------QLVFQEPGWDILLIPDERQETFPDEFQERTLVLS--------------------------DTRRGP--------------------ILPVGRIDLPKSQDFQYLQEEISWETEALA-------------------------QLSKDSQNDVFHTILKNLKLKDRGTLQDLMDMLDRDPLGPVD-------------SSGGTFLSKMQEDPRNP-------------------------------------------------------WLQSRSHIMYLLEAIVALSDTQ-HELLAWSMEKRILLQQRELVRSILEPNFRYPWSIPVRLQPELLAQLQEEGVAITFALLEECGLRVEPGNLKATWD--LEVKKPLCALYAALSGLQQLVVA------------- pigGSDM_B ---------MPKEFEAATRAVVREV--DPQGDWIAVRSLTDADRFHCLYLVKKKKR-----FFGHQYDKADLRLVDILEVQEGDELFDKLVSGLQDHK-------APFRVTDNVDSKGGLTV-KLPENMMFEVATYRSR--KCNAEVSGSRTPR-QLLAALENTKLKR--------KLPDSFQSIRAMREDLYLVTETLTTTKTETLESEQGCVIQLLVDCLGF------------------RYRRKRQKAVTVPPGTVLGYRLK----------QLVFPNEESMNIIS-EKTKSFPHEKDGGASCL------------------------------------------------------------GKSLSLEGSRSMKEKVQDLVRVLQ-------------------------DLTEKEQKWVLSCLTK--CLTEDEQLRDLQQRVSEVQCSGELRME----------GPADPLISSLFNTAGIL-------------------------------------------------------VEARVEALWDVLDALEELSEER-RFVAEALENRTLPLLK-GEMESILEQN----------------------------------LGE---KLGDEGFD--PEAR-TLWALYVVVSILLQL-EKPTSVSS------- pigGSDM_E ------------MFAKATKNFLREV--DTGGNLTAVSNLNDSDKLQLLSLVTKKRRFWCWQKPKYQF--LSVTLGDVL-TEDQ-----ILSPVVVESDFVK------YEGRFENHTRGALK--TALG--KAKLTLGGKGFVESQSSFGTLRKQE-VDLQQLIRDAQGR----TIDLKNPVLQQVLERKNEVLCVLTQKIVTTQQCVISEHVQMEK-CG-VVGIQLKT------VQVSVMDRGNISKGSNVVLEIPAPTTLAYGVI----------ELYLRVDGQFEFCLLQEKHGGFQ-QTRESSCASLEPLPLLELGFWDMTDAL---------------------------------QGASVVDEPLGVLKQVTWLLKRNVHPFA-----------------------------ELPEPQQTALNDVLQE--VLFDEEMLVVLEQVCDSVASSRLLPPLAGLG---ELKPSQQQQLMAFLQLAGCS-----------------------------------------VQGGVPDPEDV-VSNRKLFSTAYLLVSALAEMPDNAAVLLGTCCKLQIIPTLCHLLYALSDEGMSDLEDPMLAPLKDAETLEIVQHLFALADINLEML-QSSVQATASKDPAVLPLILYISLNGLCALGRAH------------------ pig_pjvk ------------MFAAATKSFVKQV--GDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTS--TPFTLKDIL-LGDR-----EISAGISSYQLLN------YEDESDVSLYGRR---GNHIVNDVGINVTGSDSIAVKASFGIVTKHE-VEVSTLLKEITTR----KINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSV----------HAGIRGEA-------MRFHFMDEQNPKGRDKAIVFPAHTTIAFSVF----------ELFIYLDGAFDLCVTSVSKGGFEREE------------------------------------------------------------------------------TATFAF-------------------------------LYRLR-----NILFER--NRRVMDAISRSQFYLDDLFSD---------------YYEKPLSMSDIS----------------------------------------------------------------LKEGTHIRVNLLNHNIPKGPCILCGMGNLKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK--------------------------------------------------------------------- go_GSDMA ----------MTMFENVTRALARQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYVRTDYTLLDVLEPGSS------PSDPTDTGN-------FGFKNMLDTRVEG--DV-DVPKTVKVKGTAGLSQNS--TLEVQTLSVAP-KALETLR-ERKLA--------ADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQG-------------SINHKE--AVTIPKGCVLAFRVR----------QLMVKGKDEWDIPHICND---NMQTFPPGEKSGEEKVILIQASDV-------------------------------------------------GDVHEGFRTLKEEVQRETQQVE-------------------------KLSRVGQSSLLSSLSK--LLGKKKELQDLELALEGALDKG-----------------HEVTLEALP-KDVLL-------------------------------------------------------SKEAVGAILYFVGALTELSEAQ-QKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMWD--PDTLPRLCALYAGLSLLQQLTKAS------------ Go_GSDMB ---------MFSVFEEITRIVVKEM--DAGGDMIAVRSLVDADRFRCFHLVGEKRT-----FFGCRHYTTGLTLMDILD-TDGDKWLDELDSGLQGQK-------AEFQILDNVDSTGELIV-RLPKEITISGSFQGFH--HQKIKISENRISQ-QYLATLENRKLKR--------ELPFSFRSIN-TRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHL------------------SYKHKGQREVTIPPNRVLSYRVK----------QLVFPNKETMNIHFRGKTKSFPE---------------------------------------------------------------------GKSLGSEDSRNMKEKLEDMEGVLK-------------------------DLTEEKRKDMLNSLAK--CLSKEEIRQDLEQRVSEVLISRELHME----------DPDKPLLSSLFNAAGVL-------------------------------------------------------VEARAKAILDFLDALLELSEEQ-QFVAEALEKGTLPLLKDQVK-SVMEQN----------------------------------WDELASSPPDMDYD--PEAR-ILCALYVVVSILLELAEGPTSVSS------- Go_GSDMC ---------MPSMLERISKNLVKEI---GSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFSLNDILEPSSS------VPETVVTGP-------FHFSDIMIQKHKADMGV-NVGIEVSVSGEASVDHGC--SLEFQIVTIPS-PNLEDFQKRKLLD--------PEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILGKIAL-WITYGKGQ---------GQGESLRVKKKALTLQKGMVMAYKRK----------QLVIKEK---AILISDDDEQRTFQDGYEISAMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPK-EQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLA-------------------------QLSKDVQDVMFYSILA--MLRDRGALQDLMNMLELDSSGHLD-------------GPGGAILKKLQQDSNHA-------------------------------------------------------WFNPKDPILYLLEAIMVLSDFQ-HDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNPRSTWD--VEAKVPLSALYGTLSLLQQLAEA------------- Go_GSDMD ---------MGSAFERVVRRVVQEL--DHGGEFIPVTSLQSSTGFQPYCLVVRKPS--SSWFWKPRYKCVNLSIKDILEPDAP------EPDVQRGRS-------FHFYDAMDGQIQGSVEL-AAPGQAKIAGGAAVSDSSSTSMNVYSLSVDP-NTWQTLLHERHLRQ-------PEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGAMCLQGE---------GQGHLSQKK--TVTIPSGSILAFRVA----------QLVID--SDLDVLLFPDK---KQRTFQPPPTGHKRSTSEGAWP----QLPSGLSMMRCLHNFLTDG------------------------VPAEGAFTEDFQGLRAEVETISKELE-------------------------LLDRELCQLLLEGLEG--VLQDQLALRALEEALEQGQSLG-PVEPL--D------GPAGAVLECLVFSSGML-------------------------------------------------------VPELAIPVVYLLGALTMLSETQ-HKLLAEALQSQTLLGPLELVGSLLEQSAPWQERSTMSLPPRLLGSSWGEG-APAWVLLDECGLELGEDTLHVCWE--PQAQGRMCALYASLALLSGLSQEPH----------- Go_GSDME ------------MFAKATRNFLREV--DADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQF--LSLTLGDVL-IEDQ-----FPSPVVVESDFVK------YEGKFANHVSGTLE--TALG--KVKLNLGGSSRVESQSSFGTLRKQE-VDLQQLIRDSAER----TINLRNPVLQQVLEGRNEVLCVLTQKITMMQKCVISEHTQVEEKCGGIVGIQTKT------VQVSATEDGNVTKDSNVVLEIPAATTIAYGVI----------ELYVKLDGQFEFCLLRGKQGGFE-NKKRIDSVYLDPLVFREFAFIDMPDAA---------------------------------HGISSQDGPLSVLKQATLLLERNFHPFV-----------------------------ELPEPQQTALSDIFQA--VLFDDELLMVLEPVCDDLVSG-LSPTVAVLG---ELKPRQQQDLVAFLQLVGCS-----------------------------------------LQGGCPGPEDA-GSKQ-LFMTAYFLVSALAEMPDNAAALLGTCCKLQIIPTLCHLLCALSDDGVSDLEDPTLTPLKDTERFGIVQRLFASADISLERL-KSSVKAVILKDSKVFPLLLCITLNGLCALGREHS----------------- Go_pjvk ------------MFAAATKSFVKQV--GDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTS--TPFTLKDIL-LGDR-----EISAGISSYQLLN------YEDESDVSLYGRR---GNHIVNDVGINVAGSDSIAVKASFGIVTKHE-VEVSTLLKEITTR----KINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSV----------HAGIRGEA-------MRFHFMDEQNPKGRDKAIVFPAHTTIAFSVF----------ELFIYLDGAFDLCVTSVSKGGFEREE------------------------------------------------------------------------------TATFAL-------------------------------LYRLR-----NILFER--NRRVMDVISHSQLYLDDLFSD---------------YYDKPLSMTDIS----------------------------------------------------------------LKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK--------------------------------------------------------------------- orca_gsdmC ---------MPSLFEPISKNLVKEL---GDKDLRPVKYMLSTSKFHQLALLWKKKGTHAQFWGQPA-VPVEYT?VDILEPSSS------VPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMRGP--------------------ILPMGRIREPTGQDFKHLQKEVCRETEATA-------------------------QLPKDTQDAILHNILA--RLKDREALQDLMDLLDWGPSDHLD-------------SFGGTFLSEMQEDSRNL-------------------------------------------------------WLKLRLHIISLLKAILGLSDTQ-HELLAWSMEKRILLQQRALVKSILEPNFKYPWNIPFTLDPKLLTPLQVEGLAITFSLLEECSLRVAPDSPKGT?D--LESKKPLFTLYGSLSVPQQLAKA------------- orca_gsdmB ---------MLAVFEKIARAVVQHM--DAGGDMIAVRSLIDADRFHCFYPVKERRR-----FFGYQYDKRDLTL?DILEMDKGEGLFDKLVPGLQGQE-------VKSQVMDSVDSKGSLTV-KLPKEKTLDMGITFSRSPEQGIELSKTWILQ-KFLDSLKNKKLKR--------KLTPMFQSIQAMREDLYLVTETLKTTKTVILKSEKQYIFWDPMKCFGL------------------RYEHKHQTEVSITPQKVLGYRVK----------QLVFPNAESMEK---DGGSSCT----------------------------------------------------------------------GKSLSLEDFPSVKERMQDMVRVLQ-------------------------NPT-EERKEVLSCFTK--CLSKDEELQDLERRVSEVRRSGELQME----------GPA--VIFHCIYAAGIL-------------------------------------------------------IEEHTEAISDFLDDLIELSEEG-QLVAEALVKGTLP------VEPILEQN----------------------------------QGE---QPRDVGCD--PEAR-TLCALYIVVSILL------------------ orca_pvjk ------------MFAAATKSFVKQV--GDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTS--TPFTLKDIL-LGDR-----EISAGVSSYQLLN------YEDESDVSLYGRR---GNHIVNDVGINVTGSDSVAVKASFGVVTKHE-VEVSTLLKEITTR----KINFDHSLIRQSRRSRKAVLCVVMESIRTTRQCSLSV----------HAGIRGES-------MRFHFMDEQNTRGRDKAIVFPAHTTIAYSVF----------ELFIYLDGAFDLCVTSVSKGGFEMEE------------------------------------------------------------------------------TATFAL-------------------------------LYRLR-----NILFER--NRRVMDAISRSQLYLDDLFSD---------------YYDKSLSMSDIS----------------------------------------------------------------LKEGTHIRVNLLNHSIPKGPCILCGMGSFKRETVYGCFQCSADGQKYVRLHAVPCFDVWHKRMK--------------------------------------------------------------------- orca_gsdmE ------------MFAKATRNFLREV--DAGGNLITVSNLNDSDKLQLLSLVTKKKRLWCWQRPKYQF--LSVTLGDVL-TEDQ-----FLSPVVVESDFVK------YEGKFENHVSGTLE--TALG--KVKLNIGGKGLVESQSSFGTLRKQE-VDLQQLIGVAQER----TINLKNSVLQQVLERKNEVLCVLTQKIVTTRKCVISEHVQIEEKCGGMVGIQTKT------VQVSATEDGNIIKDSNVVLEIPAPTTIAYGVI----------ELYVRADGQFEFCLLQGKHGGFE-HERRSDSAFLDLLPLREFAFWDTPDAG---------------------------------QGLPASDGPLSVLKQAPLFLERNFHPFV-----------------------------ELPEQQQRALNDVLQA--VLFDEELLLVLEQVCEDIVSS-LSPSLAVLG---KLKPSQQRDLVAFLRLVGYS-----------------------------------------VQGECPGPEDV-VHNQKLLSTAYFLVSALAEMPDNAAGLLGTCCKLQIIPTLCHLLHALSDDGVSDLEDPVLAPLKDTERFGIVQRLFASADINLERL-QPSVKVATRKDPNVFPLILYISLNGLSALGRA------------------- orca_gsdmD ---------MASAFARVVRSVVQEL--DHGGELTPVDSLQSSTSFQLYCLLGRKSS--SSRFWKHRYTRVNLSIRDILEPDAP------EPAVECGNT-------FHFHDAMDGKMQGSVEL-AAPGQGKLSGGAAVSGSSSASMIVCTLRVAP-NTWEAMHRERRLRR-------PEHKVLQQLRNRGDDVFVVTEVLQTQQEVEVTRTQKQEGSGQFALPGAMGLQGR---------GEGHLSQNK--MVTIPAGSILAFRVA----------QLVIG--SDWDILFFPDK---KQTTFRPQQEGGQLQRSS--------CLTS-TKFLSLRFKFLSDGP-----------------------MEDRLATTEGFQGLQAEVEAWAVGLE-------------------------GLSREPCRQLLGALGQ--VLRDEAALQALDESLEHGLRGG-LLESR--D------GPVGAVLECLVFSSRRL-------------------------------------------------------EKRLAGPVFYLLQALAVLSATQ-HVLLAEVLEMGALSGAFKLVESLLEQSTPWQEHRAVSLPHELLGSSWGSE-APTWVLLEECGLEPQVGAPQVCWK--PEAQGCANALYACLALLFRLSRLC------------ seal_ga2 ----------MTTFENVTRALARQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYVRTDYTLLDVLEAGSS------PSDPTDSGN-------FSFKNMLDARVEG--EV-DVPKTVKVTGTAGLSRSS--TLEVQTLSVAP-KVLETLHQERKLS--------AEHPFLKEMRDRGENLYVVMEVVETVQEVTLERAGKAEGCFSLPFFAPLGLQG-------------SINHKE--AITIPKGCILAFRVR----------QLMVKGKDEWDIPHIYND---NMQTFTPGE-----------------------------------------------------------------EEHEDFKTLKEEVQREIQEVK-------------------------KLSRVGQSSLLTSLSK--LLGKKKELQDLELMLEGALDKG-----------------HEVTLEALP-KDVLV-------------------------------------------------------SKEAMGGILYFLGALTELSEAQ-QKLLIKSVEKKILPMQLKLVESTMEQSFLQDKDGVFPLQPDLLSSLGEEELTLTEALVGLSGLEVQRSGPQYTWD--PDTLPRLCALYAGLSLLQLLTKAS------------ seal_ga1 ----------MTTFENVTRALARQL--NPRGDLTPLDSLIDFKRFHPFCLVLRKRK--STLFWGARYVRTDYTLLDVLEAGSS------PSDPTDSGN-------FSFKNMLDARVEG--EV-DVPKTVKVTGTAGLSRSS--TLEVQTLSVAP-KVLETLHQERKLS--------AEHPFLKEMRDRGENLYVVMEVVETVQEVTLERAGKAEGCFSLPFFAPLGLQG-------------SINHKE--AITIPKGCILAFRVR----------QLMVKGKDEWDIPHIYND---NMQTFTPGEKP--------EEKFT-------------------------------------------------KEEHEDFKTLKEEVQREIQEVK-------------------------KLSRVGQSSLLTSLSK--LLGKKKELQDLELMLEGALDKG-----------------HEVTLEALP-KDVLV-------------------------------------------------------SKEAMGGILYFLGALTELSEAQ-QKLLIKSVEKK-LPMQLKLVESTMEQSFLQDKDGVFPLQPDLLSSLGEEELTLTEALVGLSGLEVQRSGPQYTWD--PDTLPRLCALYAGLSLLQLLTKAS------------ seal_gsdmB ---------MWSVFEEITGVVVQEM--DAGGDMIAVRSILDADRFHCCSLVRGRRN-----FWGHQYHRTDLTLEDIER-GKGKGLFDKLGSGPQGQK-------AEFQVLDMVDSKGMLTV-KLPKEITTVGAFHRSH--KQRVKILEPRIPQ-QYLDSLEHWELRR--------RLPTLLQSIWRMRADLYLVTEILEMARKETLKSEWLCTLWSRVNA---------------------SCNTK------------------------------AFPEG--------------------------------------------------------------------------------------KSLSLEDFRNMKKKEQDMVRGL?-------------------------DLTEKEQKDVLSCLRG--QLP-------LSAKVGLVLISPHLEME----------GLAGLLISSLFNAAGFL-------------------------------------------------------VKAHTESILDILDALIT-SEEQ-HLVAEALEKGTLPLLKDQVRQSVLEQN----------------------------------WSE---QPHDMGWD--PNAR-LLCALYVALSLLLQLGEKPTSVPS------- seal_pjvk ------------MFAAATKSFVKQV--GDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTS--TPFTLKDIL-LGDR-----EISAGISSYQLLN------YEDESDVSFYGRR---GNHIVNDVGINVTGSDSVAVKASFGVVTKHE-VEVSTLLKEITTR----KINFDHSLIRQTRSSRKAVLCVVMESIRTTRQCSLSV----------HAGIRGEA-------MRFHFTDEQNPKGRDKAIVFPAHTTIAFSVF----------ELFIYLDGAFDLCVTSVSKGGFEREE------------------------------------------------------------------------------TPTFAL-------------------------------LYRLR-----NILFER--NRRVMDAISRSQLYLDDLFSD---------------YYDKPLSMTDIS----------------------------------------------------------------LKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGHKYVRLHAVPCFDVWHKRMK--------------------------------------------------------------------- seal_gsdmD_( ---------MASAFESVIKSVVREL--DHSGELIPVDSLRSSTSFQPYYLLGRKLS--RSWFWKPRYKSINLSIRD-LEPDTP------EPAVKQSAP-------IHIYDSMDGELQGSGEL-EAPGQGRFAGGAAVFDNFSISMNVRTLQVDP-NIWDAMKQERRLRQ-------PEHKVLQQLRNCGNDVFVVTEVLQTQKEVKVTQTRKQEGSGQFTLLGAISLQGQ---------GQGHRSRKK--TVTIPSGSILAFQVA----------QLLID--SDWDILLFRDKKHKKQRTFGLPKKGHQLTRGAGS-----------QSLLSGCFKIQSDGF-----------------------AEDWSAVTGDFRGLQAEVGAQAQVLQ-------------------------GLSKELCERLLAGLVQ--VLREEPALQTLEDTLEQGLCCG-SVAPL--D------GPVDTLLECLVQSSGEL-------------------------------------------------------ETHLAGPILYLVEALAVLSESQ-HELLVEMLETEGLSGQLKLVGSVLEQSTPWQERRHVSLPQELLGSSWDPE-APAWVLLEECGLGVQVDVPQVCWE--PQAQGRTCALYACLALLLGLSQDCC----------- seal_gsdme ------------MFAKATRNFLKEV--DAGGNLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQF--LSVTLGDVL-TEDQ-----FLSPVVVESDFVK------YESKFQNHVSGTIE--TALG--KVKMNVGGKGLVESQSSFGNLRKQE-VDLQQLIRDSTER??EFSINLRDPMLQQVLERKNEVLCVLTQKIVTTQPCVISERVQIEERCGGVVGIQTKT------VQVSAKEDGNIVKDTNVVLEIPAPTALAYGVI----------ELYVKLDGQFEFCLLQGKHGGFE-LER-SGSVFMDPLPFQEFASGDMPDAG---------------------------------QGPSALDWPLSVLKQATLLLERNFHPFA-----------------------------GLLEQQQTALNNVFQA--VLSDEESLMALEQVCEDVVSG-LSPPLAILG---ELKPLQQQDVMAFLCLVGYG-----------------------------------------VQGGCPGLADT-LSNQKLFSTAYFLVSALAEMPDNAAALLGACCKLQIIPTLCHLLRALSDDGVSDLENPDLAPLKDMEKFMIVQRLFALANMNLERL-QSSVKVVTQKDPSIFPLILYISLNRLCALGRAH------------------ Flyca_gsdme ------------MFAKATKNFVRET--DSGGDLIPVSQLNASDKLQLLSLVTKRRKFWCWQKPKYHF--LTVTLSDVL-TEDK-----PIKPVIVESDFAK------YMGKFEDFVQGSIE--TSFL--KISLGTGGKGYVENQSSFGNLRKQE-IDLQQLMKDVKDR----TIDLKSSLLQQVIERKREVLCILREKIITTQRCTISEHIQTEEKVSGVVGCTAKT------IKVSVSEDGSLVKDSSVILEIPPATTIAYGVI----------ELFIKQNGQFEFCLLDEQQGGFE-KESTEGSAYPHSVQFRDAAFLYQPDAVDNEMYS-------------------------GAKNLIPSDASISILKQDLSRLKTQFQPFV-----------------------------KLPEDKQRALYKTLCE--LLLREEMVTALGDMFDDICTG-GKP---DLE---ELKLEQQRDLLDFLQLLGCS-----------------------------------------LQSELLLQKYQ-PQDEELFSAAHLLISAVSELPDDTLVLLRACCDLQVVPALCCLPNVASADGTVALSSPLVATLADRGKFEVVQRLFASSNINLEMT-ESSVKAVTVKEPRFFPLVLYVALYGFHALGGNVSEL--------------- fice_PJVK ------------MFAAATKNFVKQV--GDGGRLVPVPSLSEADRYQPLSLVIKKRKCSLSKKSKFAS--TPFTLKDIL-QGEK-----EISAGVSSYQLLN------YEDKSDVSLNGKR---GNQIMNDVGFDVAGSDSVAFKASFGIVTKHE-VEVPTLLKELTTR----KINFDHCLVHQSRKSRMEVLCVVMESIRTTRQCSLTV----------HTGMRGET-------MRFHIIEDQNYKGRDKAIVFPAHTTIAFSVF----------ELYIHLDGNFELCVTPIAKGGFEREK------------------------------------------------------------------------------SGSSSLTK-----------------------------LRRLK-----NNLFHR--NKGVVEIVANSDPYLEDLFAD---------------YYEKAASMTDLSTSY-------------------------------------------------------------LRDGSHIRINLLNNNIPKGPCVLCGMGSSKRETVYGCLECSFNGQKYVRLHAVPCFDLWHKRMK--------------------------------------------------------------------- flyca_gsdmA ------------MFKNVTKFIVNQM--DPCKELVPVESIADNEHFRPLYLLKRKRKPKTIFHPAPYYQRTGFTLHDVLLPGED----GKSIESLHQDS-----CQITITKASKDQADGGLSI-SCDPASVDLQGGGSLSKEF-SITPQKKSISL-QSLEALRRE-REIN-------MDHSFIQQLRRTDINLYVVTEILEASEETVYKESTKADGGFKAKFYATLCAKQ------------GTREDKQ--TIVIPKGCTLAFRTI----------PLHIRDGAWDLDYFPVEALRRAAYIADGPSQG-------------------------------------------------------------------KLGVVASEVKYSCRNFP-------------------------DLSPDVLLIVFNTIKA--VMRDKNLLQELTQKMEDIPEQNDGYELKTES------PHLKDLFSTLQHSPRDC-------------------------------------------------------LLQVAGGITYVLDALHAELMDDQLLLLLESLERKILSQQLKLVENLLKHDLDKGKS-FHVDARLLSFP-HEEELMLTMELVELSGVQLQEDGSAVPRD---QPFESVAALFVAMYALNLLSGSKGACSKGQ----- turkey_gE ------------MFAKATRNFVRET--DSGGDLIPVSHLNASDKLQLLSLVTKRKKFWCWQKPKYHF--LAVSLSDVL-TEDK-----PIKPVIVESDFAK------YMGKFEDVVQGSIE--TSFG--KISLGAGAKGCVESQSSFGNLRKQE-VDLQQLMKDVKDR----MINLNSSLLQQVIERKREVLCILREKIITTQRCTISEHIQTEEKVSGLLGCSMKI------VQVSVSDSGSMMKDSSVILEIPPATTIAYGVI----------ELFIKCDGQFEFCLLDEQQGGFE-RESSEGSTSPHSVLFRDTSFLYHPDAVDNGMYF-------------------------GSENPIPSHASLSVLKEGLSQFKAQFQPFV-----------------------------KLPEDKQRALYKSLCE--LLLHEETLTALEDVLDALCAG-DKP---DLK---ELKPAQQQDLADFLQLVGCS-----------------------------------------VQDELLLQNYQ-LQDEELLSAVHLLISAISELSDYTLVLLRACSDLQVVPALCCLPYIASADGTLALSSPLVATLTDRGRFDVVQRLFASANINLEKT-ESSVKAVTMREPRFFPLVLYVALCGLHSLSGTVEELF-------------- turkey_GA2 ------------MFKKITQKVAKQM--DPKGDLVPVHSISDQDHFRLLCLVRRKRKAR--FRPFPSYRRTEYRLHDVLLPGEE----KDSVESLLPSTDGHSPRQFTTTGSVRDSVDGTLSI-PTEPAEVELGGAASVSKQW-HIKLEKKHILV-PKLEALREE-RKIN-------MKHTFIEQLRKARQNLYVIHETIETSEEARYEESTEAEAKFMAQLYAKFSAK-------------GTTGSKQ--SITIPRGCTLAFRAM----------QLTIGDAMWGKRHRKQEYL--VTFWFAGFAPR-------------------------------------------------------------------EVDAVEKEAKEKCHILS-------------------------QLADELNAIIVKSIKA--VMRDRNLLEELTEKMEALLDDPDNCELTTQS------PDLEVLLSTLKISARCD-------------------------------------------------------LLSLTEAISYTLDAFS-ELTEDQLLLLLESWEVKIVPQQLKLVRSILEQNAEHS----TAAGLLPSFSQQQQQQQLTTAVLEMSGVELQGSSAAVCKE---ENFPSLAALYAALHALHCL---------------- TURKEY_PJVK ------------MFAAATKNFVKQV--GDGGRLVPVPSLSEADKYQPLSLVIKKRKCLLSKKSKFAS--TPFTLKDIL-EGEK-----EISAGVSSYQLLN------YEDKSDVSLNGRR---GNQIINDVGFDVAGSDSIAFKASFGIVTKHE-VEVPMLLKELTTR----KINFDHCLVHQTRKSRMEILCVVMESIRTTRQCSLTV----------HTGMRGET-------MRFHIIEDQNNKGRDKAIVFPAHTTIAFSVF----------ELYIRLDGNFELCVTPIAKGGFEKEK------------------------------------------------------------------------------SGSSSM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ chGSDM_A ------------MFKKVTQKVAKQM--DPKGELVPVHSISDQDHFRLLCLVRRKRTAR--FQPSPSYRRTEYSLHDVLLPAEE----RDSVESLLPSTDSHSPREFTTTGSTKDRVDGTLSI-PIDRAEVELGGAASTAKQW-HVKLEKKHILV-PKLEALREK-RKIN-------MKHTFIEQLRKVRQNLYVIHETIETSEEARYEESTEAEAKFMAQLYAKFSAK-------------GTTGSKQ--SITIPRGCTLAFRAM----------QLSIGDAAWGVNHFPENNQ--PTFASDGFAHT-------------------------------------------------------------------EVEALEEEVKERCGILC-------------------------QLTDELNAVVVKTIKA--VMRDRNLLEELSGKMEAVLDDPDNCELTTQS------PDLEVLLSTLKGSPRCD-------------------------------------------------------LLSLTEAISYTLDAFS-ELTEDQLLLLLESLEVEIVPQQLKLVRSILEQSAELG----AAAGLLSSFSEQQQQQ-LTTAVLQLSGVELQGSGAAVCTE---ESFPSLSALYAALHALHCLVGAGGRPARAD----- chGSDM_E ------------MFAKATRNFVRET--DSGGDLIPVSHLNASDKLQLLSLVTKRKKFWCWQKPKYHF--LAVSLSDVL-TEDK-----PIKPVIVESDFAR------YMGKFEDVVQGSIE--TSFG--KISLGAGAKGCVESQSSFGSLRKQE-VDLQQLMKDVKDR----MINLNSSLLQQVIERKREVLCILREKIITTQRCTISEHIQTEEKVSGLLGCTTKI------VKVSVSDSGSMMKDSSVILEIPPATTIAYGVI----------ELFIKCDGQFEFCLLDEQQGGFE-RENAEGSTSPHSVLFRDTSFLFHPDAVDNGMYS-------------------------GAENPVPSHASLSVLKKDLSQLKAQFQPFV-----------------------------KLPEDKQRALYKSLCE--LLLHEETLTALEDVLDALCTG-DKP---DLK---ELKPAQQQDLADFLQLVGCR-----------------------------------------VQDELLLQNYH-LQDEELLSAAHLLISAISELSDYTLVLLRACSDLQVVPALCCLPYIASADGTLALSSPSVATLTDRRRFDVAQRLFASANINLEKT-ETSVKAVTMREPRFFPLVLYVALCGLHSLDGTVEELF-------------- ch_PJVK ------------MFAAATKNFVKQV--GDGGRLVPVPSLSEADKYQPLSLVIKKRKCLLSKKSKFAS--TPFTLKDIL-EGEK-----EISAGVSSYQLLN------YEDKSDVSLNGRR---GNQIINDVGFDVAGSDSIAFKASFGIVTKHE-VEVPTLLKELTTR----KINFDHCLVHQTRKSRMEILCVVMESIRTTRQCSLTV----------HTGMRGET-------MRFHIIEDQNNKGRDKAIVFPAHTTIAFSVF----------ELYIRLDGNFELCVTPIAKGGFEKEK------------------------------------------------------------------------------SGSSSMNK-----------------------------LRRLK-----HNLFHR--NKRIVSIIPSSDGYLEDLFTD---------------YYEKAASMTDLSTSY-------------------------------------------------------------LREGAHARINLLNNNIPKGPCVLCGMGSSKRETVYGCLECSFNGQKYVRLHAVPCFDLWHKRVK--------------------------------------------------------------------- lizard_gE ------------MFAKATKNFVKEV--DSGGDLIPVPSLNNLDNLQFLSLVTKKKKTWCWQKPKYYL--LSVTLNDVL-AKGE-----PIEPVVAESDFVK------YEGKFEDYVTGSIE--TSFG--RINLGAGGRGVVKSQSSFGNLKKQE-ADLQHLLKDVKGR----AINIQHTLLQQMLERKHEVLCILTERIVTTQKCLISEHVQTEEKIASMVGISTKV------IKVSVSEDGNVIKDSNVILEIPAPTAIAYGVI----------ELYIKRDGQFEFCLLHEQQGGFE-KESAEERSFP-SVAFRDSLFPHILDAVDNEKQP-------------------------DPESLIPSDASLSILTKDVLHIKTQFQPFV-----------------------------KLSEENQEALYRILCE--LLLREEVVTQLEDVLDNICST-DNPELKVMP---DLKPPEEPTIEEFLQLLGIG-----------------------------------------LLKKELMQKVPPLQNKELLLAAHFLLSAVAELSDYALVLLRACCDLQVLRILCRLPDMASRDGTLTLEDPMLAPLADAGKFWLVQRLFALSNINLEMT-ESSIRAVTTKKPRFFPIILYIALYGLCALGSKTTQA--------------- lizard_gA1 MKEKGQNYLPEMSFHKTTKSLAKKL--NPEGDLIPVRSIIDNDHYRPLCLLYRKANSS--WWKTKSFRKSEYKLTDVLCFGDH----AIKLDVKDGGQ-------FDIEDRVDGTLQGEFSG--RDIAPIEAKTNSIITHVM-SVKVKKIQLCP-TILNSVKKVFRKIN-------MDHEFIKQSKKHDYNLYIVTEAIEAVEEAHFEESSEMEGSIFYEAYVKMGLK-------------GSSKSKK--AIHIPKSCILAFRAK----------KLQVAKKSRYDDRIPNNTV-HSIFRVAPIAKKMKESRLRWFGHVQ-----------------------------------------QSDEGSVAKTALNIKENMWMEVQVECEQFS-------------------------FLSAKLRGLFLSGFVA--VMRNKDLLQKLAFQLEEALQVSGQCKLKADE------PELQNLVENLQDCSGVI-------------------------------------------------------ITELAEAVVYFLEALD-ELQEQQLMLLEESVGKNIVSMQLELVENILGNILSND----KMKFTADAQLLPKEEMIITGAMIEMSGVTIQKNEAHLTGTGEPEALVP---LYVVLYVLNLLTQKTT----------- lizard_pjvk ------------MFAAATKSFVKQV--GDGGRLIPVRSLSEADKYQPLSLVIKKKSCIFSRRSRFIS--TPFSLKDIL-QGEK-----EISAGISSYQLLN------YEDKSDVALNGRR---GNHIMSSAGVNIAGSDSLAVKASFGIVTKHE-VEVPTLLREMANR----KMNFEHCLVRQSRESKRTVLCVVMESIRTTRQCSLSV----------HAGMRGDT-------MRFHIIDDHNYKGRDRAIVFPAHTTIAFSVF----------ELYIQLDGNFELCVAPESRGGFEKEP------------------------------------------------------------------------------SRSFSFIR-----------------------------LR--------NTLFHR--NKRVMDIIAHPDNYLDDLFAD---------------YYEKAASLTDISASY-------------------------------------------------------------FREGAHIRVNLLNNNIPKGPCSLCGMGSSKRETVYGCLECSFNGQTFVRLHAVPCFDLWHKRLK--------------------------------------------------------------------- turtle_GA ------------MFYKVTKQLVKQL--VPDGDLLPVCNLIDQDHFRPLCLVRRKPKKA--FCRTLHYAKTGFRLWDILVPGED----STHLDVQDSGP-------ITVVDCVDGTLKGSVKV-PVDFGRMEAMGAASTYQVK-SIKMKKVHVSP-ANLELLKKE-RKIN-------MNSSFIKQLRESRENLYVIYEAVQALEETTFFKSNTTEGSILNEIYVHFSLK-------------GTRGSKR--AIIIPKDCVLAYRIL----------PLIIADESWDLSYHPG----GKTFVADGATEEYDYS---------------------------------------------------YDGG---------IDDLKTEVENKCAELS-------------------------QLSTDLRAKFLKSIIA--VIIDSDLLQELKFKLEEAFEDADKCELKSDN------PDLEDLLNNLQDSAGSI-------------------------------------------------------NLFLVDPVLYTLHALE-ELTEDQLLRLAQSVEKKIVPKQLELVKSILKQEASSL----DANIISS---LQEEELNITKAMIEMDGVKLQRNGLYPIKTGDMAAFAAFSALYVALYALHLLSRSE------------ turtle_GE ------------MFAKATKNFVRET--DCGGDLIPVSRLNDSDKLQLLSLVTKKKKLWCWQKPKYHF--LTVTLNDVL-TEDK-----PIKPVVFESDFVK------YEGKFEDFVRGSIE--TSFG--KINLGAGGKGFVESQSSFGNLRKQE-ADLQQLMKDTRGR----TINLNSNLLQQILERKHEVLCILTEKIVTTQKCLVSEHIQTEEKCGSVVGFSTKI------IKVSVSENGNVRKDSNVVLEIPAPTTIAYGVI----------ELHIRRDGQFEFCLLHEQEGGFE-RENTEGSSYPYSLPFRDSSFLYQPDAVDNERRS-------------------------GDRSIIPSNASLSVLKQDLLLLKVQFQPFV-----------------------------MLPEDKQGTLYKIFCE--LLHREEMVTALKEVLDSICTG-DKPDFTELK---ELKPAEQQHVTDFLQLVGYS-----------------------------------------LQNELLSQKDQ-LLSKELISAAHMLISAVAELSDCTLALLHACCDTHMVSALCCLPNVASADGTLTLREPALTPLTDTGRFHIVQRLFALANINLEMT-ESSVKAVTMKAPSFSPFILYIALYGFYALGGAV------------------ turtle_PJVK ------------MFAAATKNFVKQV--GDGGRLVPVPSLSEADKYQPLSLVIKKKKCFLSRKSKFAS--TPFTLKDIL-QGEK-----EISAGVSSYQLLN------YEDKSDVSLYGRR---GNQIMSDVGVNMAGSDSIAVKASFGIVTKHE-VEVPTLLKELTSR----KINFDHCLVRQSRESRKEVLCVVMESIRTTRQCSLSV----------HAGMRGET-------MRVNI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- frog_pjvk ------------MFSAATKNFVKQV--GDGGRLVPVPSLSEADKYQPLSLVIKKKKCFLSRKFKYIS--TPFTLKDIL-NGDK-----ELSAGVSSYQLLN------YEDKSDLSLNGRH---GNQIRNDVGINIYGSDSVAVKASFGIVTKHE-VEVPALLKELLSR----TIDLDHCLTHQAKESGKEVLCVVMESIRTTRQCSLSV----------HAGMRGEA-------MRFHLIEEQNHKGRDKAIVFPAHTTIAFSVF----------DLYIHLDGHFELCVSTASKGGFEKEP------------------------------------------------------------------------------TRSFSLNT-----------------------------LR--------NNLYRS--GKRTMDVIATTDSYMDDIFSD---------------YYEKAASMTDISTTF-------------------------------------------------------------MREGAHTRVNLLNNNIPKGPCALCGMGNSKRETVYGCFECSFNGQKYVRLHAVPCFDLWHKRMK--------------------------------------------------------------------- frogGSDM_E ------------MFAKATKNFLKDI--DAGGDLIPVYSLNDSDKAHLLGVVAKTRRFWCWQKPKYHFSSCSCTLSDIM-TEDK-----EIKPVVVESEFVK------YEGTFGDVIKGNIG--AEVG--ALQMNASGCGYVESQSSFGTLRKQE-VDMQHLMKDVHDR----RINLHHPFIKQLQENKNDVLCILKEKIVTTQKCIITEHTQTEETFKGKVSMKAKI------VKVSVSENGNYLKDENTILEIPPPTAIAYGVV----------ELYIKHNGTFDFCLLSEKKGGFE-KENLEKHQHSNPLPSDQLVLFDCTMVI---------------------------------YPLKKKDTYVSILPKGIAAHEKHFSAWK-----------------------------QLPDVQCLELYTLLCQ--ILYDGQALSKLHAVVEDLCSK-RKPTQAAFD---ELMPSQRIIAENILYLSGYD-----------------------------------------MPNGKFLHAAN----RELLVALHILTSALNELSDSALAVLGTCCELQLLPVFSALMNMSSDEGLCSTTEPALMDFLDQERFYVSQKLFALFNIELEIK-EDFIYAATAEDPGFLPLILFIVITGLQLLKRD------------------- Lamp2p_ ----------------------------------------------------------------MTS--R---------------------THVTSYQLVN------YEDESDGAPGRRERHGSEGVLAGVGFSVARSENVAVHASLGIVTKHE-LDVPLLLRLLRNR----RVDVEHWLVRQTRASGRAVLCVVAESIRTTRQCSLAVRTSLEQKLRVHSHRSRAR-------GRAAEEGVRQGKGRDKTIVIPAHTTVAFSVF----------ELYIRLDGSFELCVAAELPGGFEREE---------------------------------------------------------------------TLGERLRRLVARLAVWRGSS------------------------SPSRSLRAAPEGRTSPSD--MKGGYRPSSRRSSTADTTTVD---------------FYEQTATLTDLSGPSGVGASSTS------------------------------------------NVGGRGGGFPPEEPGAHQRVNLLHQGVSKGPCALCGLGARPRDTVYGCVECAWGGHKYVRLHAVPCFDLWHRKMKS-------------------------------------------------------------------- medaka_GEa ------------MFSNATANFVRQI--DPNGSLIHVSRLNDSDKLVPMGLVVKRNRIWAWQRPKYRP--TDFILSDLL-QGDL-----KLEPGVSQMDFLT------YKGTYIDKKSAMLD--VRAG--GANAGLEGQGASKLHSSFDNLKKEE-LDVRKLLSDSSN----RLVDMHHVLVQQLE-KRADVLAVVKERILTTSPCSVTLRRKQQCGFHGVLSLLSLLG-----SSRNEKKKNNVEMNSDVSLEIPSGTVIAYSVL----------ELQVQKNGHYDICLQPGRIGGFADNPDPISRSLHH-------------------------------------------------STDTVDSLCNWNN-PKEKLSEKLYIMLY------------------------------LPQSTRYPLINQLQE--TLTDRAALSYLQAVLEELCDG-DTVESIEES-------SEIQRKSTFLDQQDPV----------------------------------------------FPAED-LQRETAKLKAVYLLVSTMDELPDEALGLLSES-RPVVLLAFDELLSSLKGSGGSISIDSIPVPLQDNQAFQQAEQLFYSIGVALRRD-AEQLWMESGREDEVLLLLLSFSMHGLSLLLTGC------------------ medaka_gEb ------------MFALATKNFVDEV--DKKGLLIPVSSRNDD--IHLLTVVVKHNRFWFWKKPNYVP--TDFTLNDVL-TGDN-----PIKAEVTETDFLN------YSGTFSDLTQASVN--AELSN-AGGRSVTGKGSSTLKSSFGDLKKEE-VELQKLLHDLKDSHWHRALDMSHVLIRQTMKKHKTVLGIVKERILTTTLSSVVEEEERSGQCAGSLSFFGSLS-----KKVSLKDNTNLTKDSNVTIEIPISTTLAYGVS----------ELVIHQDGRFDLCVTSDTDGGYETDSVVGSESLD--------------------------------------------------------------LQKELDSLEDHFHLLT-----------------------------ALPASRKSFLLQEISE--LMQSPLAISTLQNALDQMHVD-QKPDLSESGL----AESHQKNIKAVLDLLG------------------------------------------------KCDE-----AVSVLSAFHLITSALEEMPSDCLTILRTSINLKVLQTLELLVQCVSGSRKKPLSS---LELEAN-IYKETKHLFESMNVSLTNK-DDVLCTKVTPHSGNLPLILCISIRGLASLDTEAKSN--------------- medaka_pjvk ------------MFAAATKNFVKQV--GDTGRLIPVPSLSEADHYQPLSLVTRKRKKHFWQKNKFSS--TSFSLKDIL-VGEK-----EITA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DICVAPESQGGFEREQ----------------------------------------------------------------------IREQLGGFIGRFSVGR-----------------------------LRRFLSGIIYGNPFRA--DDRTFEELTHSDTYMDDMVTD---------------YYEKAASMTDVSTAY-------------------------------------------------------------LRESSHTRVNLLKHNIPKGPCALCGMGNQKRETVYGCLECSSGAQKYVRLHVVPCFDLWHKTLR--------------------------------------------------------------------- tetra_GEa ------------MFSKATANFVHQI--DPEGSLIHVSRVNDSKKLVPMALVVKRNRPWFWQKPKYHP--TDFTLSDLL-QGDE-----VLCPEVSETEFLT------YNGTFGDKLSGKLD--TDAG--PVSVILEGRGSSKLQSSFGKLKKQE-LDVTKLLRDSAD----RQVDMQHVLVQQLK-KRDDVLAVVKERVLTTSSCSVTLIKKDQCTLRGVLRLMGMLHLGNSPVKVCVKENTNFEADSDVSLEIPPGTVIAYSIR----------ELNIRKNGEYDIGLQPGTTGGIES--DSLELPSWE-------------------------------------------------ALTTVDGGCQEEMLPFAMLLNGLFPFS-------------------------------PPRLMTHFLINRLRD--IMIDRSALACLQSVLEGLCCS-DSPDMTENDEL---SEGERGALSAILGQLGLV----------------------------------------------CPVEG-SSSCSLQMNAAHLLVSALEELPDETLNLLGRS-PPEFLEAFDKLLSSLKEGSEPLTVESLPALLQENRNFQLAEQLFTTASVTLRRD-ANRMWVETESKAGLHTLLLYLSVHGLVLLAKSH------------------ tetra_GEb ------------MFAAATRSFVEEV--DVGGSLIPVSSPNDG--VSALTVVVKRKRLWFWQKPKYTP--TDFKLNDLL-TGNP-----PIKPDVSESDFIK------YTGTYGDKIQGNVD--ASFSPLQASVALEGNDSSKLQASFGGLRKEE-VDMQKLLHDCKD----RILDMSHCLILQAKDKPRRAFGIVKERIVTAQPCSVVEEVQQGGQCGAGLSLCGPST-----PKVFLKDNASLLKDSNVTMEIPVHTPVAFALT----------ELEIRHDGRFELCLMSDTKGGFEVDGLHQTKAVG---V----------------------------------------------TGAPAN----DQLRQELEALGQHFHLLA-----------------------------ALPVGTRSSLLQQLTK--VLEDRRALSSLQSVLDQVCLD-ESTSLRDLPA----SESHEQTVHSILELLE------------------------------------------------PSGP--AGQRAPALAALHLIVSAMDEMTDECLALLRTCCSSAALHTLELLVRHLAGEGEMPPSG-----GDED-VYERAERLFAAANVSLKRG-GGALRVEVKQQPGQLPLVLCIAIRGLASLAR-------------------- tetrA_PJVK ------------MFTAATKNFVRQV--GDTGRLIPVPSLSEADRYQPLSLVTRRRKRSFLKKRGFAS--TPFSLKDIL-VGEK-----EIQAGVSSYQLLN------YEDKSDLMLNGRS---GNQLINDVGLNLSGSDSVAVKASFGIVTKHE-LEVPSLLRELSSR----KVDLDHCLVRQSKERGRSVLCVVVESIRTTRQCSLSV----------HAGMRGAT-------MRFQIDNSRNPGGRDKAIVIPAHTTIAFSVC----------ELFVCLDGRLDICVAPESQGGFEREQE--------------------------------------------------------------------SSTETLSEAVRHQSGSF-----------------------------LKR----------------SQTFEELTHSDAYVDDMVAD---------------YYEKAASMTDVSTAY-------------------------------------------------------------LREQGHTRVNLLKHSVPKGPCSLCGLGSQRRETVYGCLECSSGGQKYVRLHAVPCFDLWHKSLR--------------------------------------------------------------------- coe_GE ------------MFAKATCDFLEEI--DYKGDLIAVSSLDDSNKIQLLSLVTKRPSFWFWKKPKYHS--SPFTLSDVL-VGSR-----PIKPVVVESDFLK------YESKSGNTEKGTIG--ASVG--IGNLVVGGNESVELQSSFGTVRKQE-VDVHQLLKDAQER----TIDLNDRFVQQTRERK-EVLCMIREKLVTTQKCSLLEHIQEEESCGGALAFKSKR------IQVSLNENGKLQKDTNVVLEIPPQTAIAYGVI----------ELLIKCSGQYEFCLVPEKKGGFE-KEK-PPRAFDTLSCVSSQCYGDSVDFG--------------------------------RHCVDVKTIPSEVSLSALNLFFQNFDLIV-----------------------------NLISKRGSSLGKFFFF--FLCDEKLSIYIKHRLDQLVLA-EKPDLSGLH---QLKPSERKNVTNFLQLLGYT-----------------------------------------CPEN----EES--LQRELLTATHFLLSALEELSDESLVLLGTCCDLQVLPVLQHLFTSTLDDGSASLKDPALSCLTDKGKFHIVQKLFTSSNINLEMA-ESSVKAIISKQPGFFPLILGIVVTGLAALWIMHS----------------- coe_pjvk ------------MFAAATKNFVKQV--DDTGRLIPVPSLSEADRYQPLSLVTKKKKPHFWKKTKYAS--TPFTLKDIL-VGEK-----DISAGVSSYQLLN------YEDKSDVSLTGRL---GNQIINDVGFNIAGSDTVAVKASFGIVTKHE-VEVPTLLRELSTR----KVDMEHCLIRQSKESGRAVLCVVMESIRTTRQCSLTV----------HAGVRGKT-------MRFQIDDGRNHKGRDKAIVIPAHTTIAFSLF----------EVYVHLDGHFELCVTSESKGGFEKEQ----------------------------------------------------------------------ITNSL-------LFQR-----------------------------MRKIL--------YNL--DDRTPDNVTNSDLYLEDVVAD---------------YFEKATSMTDISTSY-------------------------------------------------------------LRDNSHTRANLLNHNIPKGPCTLCGMGNSKRETVYGCLDCSFNGQKYVRLHVVPCFDLWHKRLK--------------------------------------------------------------------- zfGSDM_Eb ------------MFAKATKNLLSEI--DSEGFLIPVLCLNDSDGLSPQALVIKRNRYWFWQQPKYKP--TDFKLSDVL-VGD------PINPVVVETEFLT------YKGKVMDTKSGSAV--AELG--PGTINIGGSGSSKLQSSFGNLKKQE-LDLQKLLHDSKS----RVLDMQHSLIQQTRNAKTEVLAVVKERIITTQPCTITEEVQEGGSCTGMFGFNKTIK-----VSSNDKGKPSIAYDTDVSIDIPPKTTLAYSVI----------ELDIAHTGHYELCLLPAVKGGFEIDGPVKVKQAVT--V----------------------------------------------SAAPGNP--THNMQKELVGLEGQFKVLS-----------------------------KLPSSTRFSLFQQISL--LLQNSAVISILGSTLEDLCGG-TQPDPSTLAE----VPELKVTLELIQKSAG------------------------------------------------KKPSG-QHQKQSTLTATHLLISALDEMSKPALFLLKSCCSYTTLQALLHLVQNMALNEKSSLKDAALDVLADEVVFKNITSLFNSCNVMLLKD-DNSLITKISNPEDRLPLMLCIAVKGLASLAPHV------------------ zfGSDM_Ea_(E7F9U2) ------------MFEIATKKFVRHI--DPSGVLIPASSLNDSKNLQLLAVVLKSKKRWFWQRIKYRP--TEFTLNNLLKEKKT-----QLKPEYKKEEFVK------YMETNRNVLGGSVD--VSGP--DVTLNLNGRSISNLYLRLGRLQKEY-LDIPKLLNDTRG----RKLDLKHSLIKQSKNKNK-TFAILKERIFTTCNGKINWNEEEKSGCQTVFTVFWN--------KMSIEGSGKQHHGSETKLDIPPDTVLAYSVM----------EISIDAEGCFELCLFPRGLGTDETSEIPSPVPSEVDGQ----------------------------------------------FPLMQEGFPLHTQKKALADVQTCFCALA-----------------------------DLSVELRFSILVLLRK--IMLDRTILSALVDTLETLSSD-EAPCFLTKEL----SEKQSQIIREFLHLLKWESHENNQYPTSTSLSITNGCQKSTANHSHPVMASDQNGGHSAKSNQNGCSKAASKPSMELMYAMQMLLCALEELTDAGLKLLEPFCTSEHLSSLQDLVIHLTSIMP-LCKNTVPVSLQNEDEFHRKEELFKSCNVLLKKE-NDSLTSEVTCSVGFLPLVLCIAIHGLASLSAV------------------- zfPJVK ------------MFAAATKNFVKQV--GDTGRLVPVPSLSEADRYQPLSLVTRKKKRHFWKKTKYAT--TPFSLKDIL-VGEK-----EITAGVSSYQLLN------YEDKSDVALNGRL---GNHLIHEVGVNVSGSDSVAVKASFGIVTKHE-VEVPTLLRELNAR----KVDLDHCLIRQSKESGRTVLCVVMESIRTTRQCSLTV----------HAGVRGTT-------MRFQIDDGRNPKGRDKAIVIPAHTTIAFSVL----------ELYVRLDGRLDICVAPESMGGFEKEQ----------------------------------------------------------------------IREQLGGFIGRFSVGR-----------------------------LRRFLSGIIYGNPFRA--DDRTFEELTHSDMYMDDVVTD---------------YYEKAASMTDLSSAY-------------------------------------------------------------LRDEKHTRVNLLNHNIPKGPCALCGMGHQRRETVYGCLECTSGGNKYVRLHAVPC------------------------------------------------------------------------------ Fugu_GEa ------------MFSKATANFVHQI--DPEGSLIPVSRVNDSKKLVSMALVVKRNRRWFWQRPKYYP--TDFTLSHLL-QGDK-----DLHPEVSETEFLT------YQGTFGDNLSGKLD--TEAG--TVSIVLKGQGSSKLRSFFGKLKKEE-LDVTKLLQDSKD----RQVDMQHMLVQQLK-RQDVALAVVKERIITTSSCSVTMTKKNQCTVLGMLGLMSMLG---SSVKVCVKDSANIEADSDISLEIPPGTVIAYSVL----------ELEIRENGEYGICLQPGAIGGFD-------LPSWE-------------------------------------------------SPDAVDGRCLEELLPFDAH-NGLFLFICLLPVFALLGTRIKENNQLMIEATGLHALAQLPKSTRCALFKGLQD--IMIDRSALACRQSVLEDLCCG-ESLDLTQHD------EGERTFVSAILKQLGLA----------------------------------------------DPVEGRLSSLPPQMEAVHLLVSALEELPDETLDLLSRS-TPEFLEAFDNLMSSIRESSGPLTVQSLPVLLQQNQNFQLAEQLLTTANVTMRRD-ANQLCVETGSGAELYMLLLYLSVHGLLLLAKSETDFI-------------- Fugu_GEb ------------MFAAATRNFVEEV--EVGGSLIPVSSPNDT--ISVLTVVVERKRLWFWQKPKYTP--TDFKLNDIL-TGEP-----PIKPGIAEIDFLK------YTGTYGENIEGNVG--ANFSPLQSSVTLEGKDSSKLHMSFGSLKKEE-VDMQELLRDCKG----RLLDMSHCLILQTKDKPRRTFGIVKERIVTTQPCSVIEEVQQGGQCGGGLSLCGLAK-----PKVFLKDNAYLMKDSNVTMEIPVQTTIAFAVT----------ELEIRHDGHFELCLMSDVKGGFEVDGPPRTTAAG---V----------------------------------------------TGAPAN----THLRQEMAMLSKHFHLLS-----------------------------ALPLSTRSSLLQQLSE--VLGEPGAVSSLHRALDQACPD-ERASLGHVTA----AESQEQ--NSILELLE------------------------------------------------QTAQ--ADQLAPTLTALYLTVSAMDEMTEECLALLKTCCSPEALRTLELCVSNDR-MNKAPRTCLYF-LKSRT-VDERAERLFASSGMSLRRGEGGVLRAEVGQQPRHLPLVTCIAIRGLASLAQ-------------------- fugu_PJVK ------------MFTAATKNFVRQV--GDTGRLIPVPSLSEADRYQPLSLVTKKRKRRFFKKRSFAS--TPFSLKDIL-VGEK-----EIKAGVSSYQLLN------YEDKSDLMLNGRS---GNHLSNDVGLNLSGSDSVAVKASFGIVTKHE-LEVPSLLRELSSR----KVDLDHCLVRQSKESGRSVLCVVVESIRTTRQCSLSV----------HAGMRGAT-------MRFQIDNGRNPRGRDKAIVIPAHTTIAFSVC----------ELFICLDGRLDICVAPESQGGFEREQ----------------------------------------------------------------------IREQLGGFIGHLS--M-----------------------------GRQ----------------SRTFDELTHSEAYMDDVAAD---------------YYEKAASMTDVSTAY-------------------------------------------------------------LREHSHTRVNLLKHNIPKGPCSLCGLGNQRRETVYGCVECSSGGQKYVRLHAVPCFDLWHKTLR--------------------------------------------------------------------- tila_gb ------------MFALATRNLVEEV--EDKGSLIPVTSLNDT--IALLTVVVKRRRFWCWQKSKYLP--TDFNLNDIL-TGDT-----PINPVVVETDFIK------YSGTFSDKIQGTVD--ANFS--KYSVKLQGEDSSKLQSSFGSLKKEE-MDMQKLLRDLKD----KVLDMSHCLIQQTKEKQRRVFGIVKDRIITTQPCSVIEEVQQGGQCGGSLSTCGPKI-----TKFLLKENASLGNDSDITMEIPTNTPIAYSLI----------ELKIKHDGQFELCVLSDTNGGFDKVDSPAIKKDQPC-F----------------------------------------------SGAPAHSSDSTCLQQELDQLSNHFQLLS-----------------------------ALPASTRSALLQQITK--LLQDQITISALQDVLEQMCMD-KGSALGDFKT----TACQKQNVQAILDLLE------------------------------------------------QSSQEEPSRSTSLLKALHLLISALDEMTNDCLAALGMCCSPAVLGILELLVQCASRNGESPLSTEASSVLTEA-IYEKIEHLFATCNVSLRRN-GDMVKAEIDKQPGNLPLVLCIVIQSLASLAQGV------------------ tila_pjvk ------------MFAAATKNFVKQV--GDTGRLIPVPSLSEADRYQPLSLVTRKRKRHFWKKDKYAS--TPFSLKDIL-VGEK-----EITAGVSSYQLLN------YEDKSDVALNGRL---GNHIINDVGFNISGSDSVAVKASFGIVTKHE-LEVPTLLRELNSR----KVDLDHCLIRQSKESGRSVLCVVVESIRTTRQCSLTV----------HAGMRGTT-------MRFQIDDGRNPKGRDKAIVIPAHTTIAFSIC----------ELFVRLDGRLDICVAPESQGGFEREQ----------------------------------------------------------------------IREQLGGFIGRFSMGR-----------------------------LH-----------------DRTFEELTHSDTYMDDMVTD---------------YYEKAASMTDISTAY-------------------------------------------------------------LRESSHTRVNLLKHNIPKGPCALCGMGNQRRETVYGCLECSTGGQKYVRLHVVPCFDLWHKTLR--------------------------------------------------------------------- shark_ge ------------MFATATNSFVKQI--DKGGDLIPVRSLNDSDKLQLLSLATKRKMRWFWQKPKYHS--SSFNLEDIL-TGDV-----HIKPAVKESNFLK------YEGIFENSVGGAMN--TLIA--DISFHIEGQNSIALESSFGKLRKQE-VDLHQVLKISQER----TINMRHSLVQQTRERGDEVLCVVNEKIITTQQCFISEHLQIAEKCGGMFGLKIKM------LKVSANNDGSLSK--EIVLEIPPQTVIAYSVK----------ELHLKTNGQFELCLLSDKCGGFDKAEWDKGKEAYVSTACSALDCVDASTQKHGSRHH-------------------------TDEKNVCSETSLSALKQDIEEAKQQLQPFE-----------------------------ALSEGKCQQLFRLYSE--LLYQGEAICLLETILNELSLG-EQPNLSGLH---ELEPTQVQNVKELLQFLGYS-----------------------------------------TDKEHLKKTKE-IATQELFTTVFYFISALDDMSDACRTVLGICCEMQVIPTLWHLINNLSDDGTLPIDSPGLFMLKEENKFYTAQRLFGLSHMQLERE-KSSIKVMTRKQPGVLPLILCIALHGFAGLMGLNQ----------------- shark_pjvk ------------MFSAATKNFVKQV--GDTGRLIPVPSLSEADRYQPLSLVTKKKKSCFWKKNKYSS--TPFTLKDIL-VGEK-----EVSAGVSSYQLLN------YEDKSDVSLNGRL---GNQVIHDVGFKIAGSDSVAVKASFGIVTKHE-VEVPALLREIN-R----KVDLEHCLVRQMKESRRAVLCIVMESIRTTRQCSLTV----------HAGMRRKT-------MRFQIDDGRNHKGRDKAIVIPAHTTIAFSVF----------ELYIRLDGHFDLCVTSESEGGFEKEQ----------------------------------------------------------------------ITEQLGGLMGRFSVWR-----------------------------LRRCLSEFFYGSPFRS--DGKLADISTNSDPYLEDLVAD---------------YYEKATSMTDISTTY-------------------------------------------------------------LSDNAHTRVNLLNHNISKGPCVLCGMGSSRRETVYGCLECSFNGQKYVRLHVVPCFDLWHKRVK--------------------------------------------------------------------- lance_pjvk -------MLQEEMFEAAVSGFVKAV--GKD-SLLPVPDLNSANKCRPLHVAVKKNPKWFWQSAKYLP--TSFKIHQIL-TKTE-----EIDVNVACRTLVE------YNKTSHFSVKGSV---GSKIMKEVDLDVSGSGMVSIKASFGKVNKCD-VDVPTLMQALDKR----FVDFRHDFVQEVRQNPRNVLCVVVGTACTINPSVLSSEEDVEGN--QKATIALGT-------TANINQEGEISNETDKVFDLPPETPLAYNVC----------EILVKEDGGIDLMYTRDGSGGFTAKPG--------------------------------------------------------------------SGVVQADAPPNTELAHTMKPL-----------------------LSLPEQQRN-SVTSAVLK--VMEAPADLPVVEELLDDVVDG---------------R-----KPKPFAEFKSKCTNPAAVLGFLSTID-----------------------------FQM--DTSFTDEDKALIRSLDALFDGLIELSDEQCLALKECNSNFAPAILHVLEQGIAG-NPVPLDDPAISILYVKSNNPGQDFIEAMDFGIQDVGNKKALVTEDDGKTLYAAQQAVYGLWGGL------------------------ NEMA_PJVK ----------MALFESASKQFVKDT--GRR-SLHAVPDLNSSECCRILCVIERKKSRWFWRSTKYLT--TPFVLNELL-TEPV-----DLKEKQKEEVFITD-----YQNNPQFHVSGKL---GAKIAKDLGIDVSTTDSFVVKMNIGAVNKTE-IRWQDMFSALKGK----RLNVDHEFVQAIIASKRRSLSVVCEMLATTGDTKMESELQVEGD--ADIETTGIP-------MASGKVEGSVKDSHQRSFIIPKGTVLGYGCYRLRIVDKDQGSVEMDIDKELEDKDVTDAVDGAP------------------------------------------------------------------------TAAHPFDQPDGQNDSALKSEF-----------------------KTLLESPSFGKIIECFRN--ILASPGHIKPLRDLLEDSVLS---------------LDGEKVNALKEDAFLDSMGPCQG-WRELLDIIGFQF-----------------------KE---GKIQFPNEEFREIVLPCNALAISLCDLSDAQCAALKDVTPGYLEPLLYLIRNAMYG-RSTKEDDPQLKRIFTHAANPGKSFLLSLGFAQVTEQGSK-VLALKPD-PLASLEDIYVATFVMCQK---------------------- STYLO_PJVK ----------MALFEACSKQFVKDT--GRS-TLRPILDLNTSTRSSILCVVTKKRSRWFWKTDTYKS--TPFTLNELL-TKPV-----HIKGHIEKSTFISN-----YKNEPKFHISGKL---GGKIASEFGIDASAVDSFTISMDVGTVLKRE-VTWVNLKKALADT----TLNLGHEYVQYICTKQRRSLCIIYETVATQGDTDLASDSREEGD--ASVST-GKP-------KFSISLSGSVELEHHRSYELPSNTILGYACY----------EAQFDLDTGTFELVLPDATDGGG-EVG--------------------------------------------------------------------MNYCLFDEPDGQKDKALKAVF-----------------------DDLLKSPLLGKIIGLYKE--ILSYPQAVAPLRDMLEKALSA---------------VEKKNFEPLEMKEFQTKAGPGYGPLKDLLPLIGFNI-----------------------DDSGEGSLTFSQSPEDGLLQCCTALAEALVELSATQCQTLKEVTSQYLEPLLYLLKNTMFG-KMTSIDDPLLQRLWTHSSNPAKKFLLSVGFDQVME-GNQKVLRLKWDFEHISLEDVYVAVFVMCTKI--------------------- EXAIP_PJVK ----------MALFESTSKQLVKDT--GRS-SLHPIVDLNSASQCKIMCIIEKKKSRWFWRPTKYLP--TPFTLNELM-TKPI-----DSK-KIKTSEFVSN-----YSNQPTLHVSGKL---GGKIAKELGIDVSTADSFVVKMDLGSINKSE-IRWQDLNDALKDQ----TLKLDHEFVQAILNCRRRSLCIVFETLNTTKDTNIQSDIQVEGD--AVASTDIIS-------KASVNISGSIKDTHHHSFDIPNGTVMAYGCYGLKLLEG-LGLIELDVDKKLKD-VVTDATDGKP------------------------------------------------------------------------PDAFSMDQPDGP-DTALTSAF-----------------------NALMKSPHKGDIIKCFRE--ILATPEYCHVIEQLLDNVCDY---------------FDKEKVKSYSLDEVKSLFGSCNS-WERLLTILGITF-----------------------DSKKGGKMIYPEDDKKDVVLSCCGLATSLHGLTNLQNIALKDVTPEYCDQLLYLIRNAICG-KNTPADDPRLKRIYTHSSNPGKSFLLALGFQLTKQNGKD-ILALPPD-LECPLEDAYVAVFVMAS----------------------- ORBI_PJVK ----------MALFEACAKQFVKDT--GRS-TLFPVLDLNTSARCDILCVVTKKRSRWLWKSDKYKT--TPFSLNELL-TKPV-----DISGQIKKSVFIAN-----YKNEPKFHVSGKL---GAKIATEFGIDVSAIDSFTISMDVGDVIKKQ-VHWGNLNDALADI----TLNLDHEYVQYILSKPRRSLCVIYETVATHGDSELDSDSSGQGD--ASLNA-GKP-------TFSINLSGSVQVAHHRSFELPNNTILGYACN----------EITFDSAMGTFQLVLADATDGGG-MST--------------------------------------------------------------------RECCVFDEPDGQNDKALKAVF-----------------------DDLLNSPLCSKIFDLYRK--ILSCPAAVAPLRDLLEKGLSS---------------AEKKNPKPFELKELKTKAGAAYENCKELFLLLGFNM-----------------------DESGDGNITFPQGSADGLLHCCTALTEALVELSAPQCLALKEVTSEYLEPLLYLLKNVMYS-KDTSVDDPLLQRVWTHSANPAKNLLLSLGFDQVITEGNNKLLQLTWDSEHISLEDTYVAVFVLCSE---------------------- ACRO_PJVK ----------MAVFECCAKQFVKDT--GRL-TLRPVVDLNSAIRFDILCVVIKKRSRWIWKSVKYEA--TPFTLNEIL-TKPV-----DCVSKSEKSVFIRN-----YKNEPEFNVKGKL---GGKLAQYFGIDASCIDSFTVDMNVGTVTKRE-VKWDVLNQLLADN----TLNVDHEFVQTILGKPRRSLCIVYETVSTGRDADVDSDADQEGD--ANVTG-GKS-------EFSINLSGSVQAKHHRSFELPNHTILGFACY----------EITIDPDLGTFQLLLPDSIDGGDPQEF--------------------------------------------------------------------KKHCVFDEPDGQNA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HYDRA_PJVK ----------MAMFEAATKCIAKSI---GSKTLHHVSDLNSSERFKLLCVVCQKKSFWPWKKTQIFP--TQIVLQDILLTKLN------IEQSDVNFTLVK-----DYIENPTLNIKGDVG---AKIASELQLEFSASDSVSLNINVGSLQKQE-IKWQKLDNALQSS----KVNTRHPLLEEIQFLKRTELAVVLESISTCADSTLSGSADLNVTTDDSVSNKSVVVVD-------VHTKDSIEKKTTHSYTLPSNTVLAFSCN----------TFSVTEYGGIDFHAAPDEADFSTKTLLQKTKKDSFDFVKSMLFS--------------------------------------------------FVKSSKFSSIQQFFKSIIGSVE-------------------------QSSLEAIYLLLLAVEG--SSENNFYLNSCHSALSKTIVENIGLWKPLLLSLNFFIPDDLSLNKASIKFPTND-------------------------------------------------------DDYLVKGCIGWIDAILDTDKNLRHYLVQFSDEHLKLLLHIVESKILNKEINEEIQINLMFSENQSTKLFLNGIGFVFETEEEKEVMTYPSEDHQKLLDAFINIYLLSA---------------------------- LINGU_PJVK ------------MFEAAVTKFVKSV--GQG-SLLPVPSLDEAEKCRPLAVVIKKKRRWFWQCSKCEP--TPFFLHELL-TDET-----TLGLKSETRDLVT------YNRTSRFSAKGSI---GAKLKVLFDVELSGSDTVLVEAKFGDVTKEE-VDVPTLLDVLSHR----NLQLDHEFIKQVQENPRKVLCVITGTAVTTKDCTIHSHIDWDLK--DKLSVDKLK-------AVDASTSEDVSSDGDKIFSLPANTPLAYNVT----------ELRVSSTGKLELMVEEGTKGGFDTVDS--------------------------------------------------------------------S--AYEDMGIDKEAEHQLQGI-----------------------CGMSDESRK-TFVGAVLD--ICDTPVTIDPLLVLIKQAHKA---------------ASANTEKVITVDKLRNTVGQSDAVVSLLKQIG-----------------------------FTFRDDDVVYPKASPLLDATRVLFEALIELDGEEILDFRECNSNLAKPLLHVLNQALHG-RDVPLDD--IKALYTD-RNPAQSFLNEMDFHIKGLDTLNPPAGQSN--KMEAAYIAVLALWG-------------------------- SACCO_PJVK ------------MFKSLTDKLSKSL--GED-TLLPVPSLDQADNCRPLSIVVKKNRRWFWRAPKYLP--SQYTLSQLL-SNKE-----DLDVPIINEDLTN------FDDVSSFSVKGKI---GAKIASEVDLDVKASDDIQMSSKLGQIVKNK-VNIPILQDLLTRK----KLNLTHPFIEEIRQNYRNVLCVVVGSLCTTKDCQLVAKLLREKE--QGADVGSQG-------PIQGEEDVSVVDDQTRVIRIPADKPVSYHVC----------ELHITTEGGIRLLILGEGTGGFDKPDE--------------------------------------------------------------------EKFVDIDVGEDEPDNPFID----------------------------RTESTN-PFDDP--------EPNHYEPFKSIVS------------------------------------------------------------------------------------------------LEFARQILVNPLVT----------------------------------------------------------------------------------------------------------------------- LOTT_JVK ------------MFSATAHQVAKAL---GKETLLPVPSINTADNIEILRIVIKKRRKWLFFTRKPHYETTEFTLSDVLLGEHQK----EFEVLPLDTHVLT-----AYNSKSNLSLKGKFG--ADLTKELLDVKLGSTDSVVVSSQLGVLNKTE-ISTPKLLHLLEKK----KIDLHHPLISVVKDNGHKTLCIITSIIHLKDNGKITSDVDLEGDGEFDSKPLSVD------------LEGDVKEDKSKSMVIPKNTSIAFSMV---------ELLVSVKDGSIQVILSHDENGGFTTENFDVTDG-----------------------------------------------------------PVHPECPEEILKVFKENGKCKEVLR-------------------------SVQHLLQTPKSIRSLMELEVELSHDLNILQAYTKQNLYDEFDMEESHNYHPFLLLADFHFKDEKLLIPDESS---------------------------------------------------------SMFNACHFLLTLLHELDEDNILDVLAQCLMVTKTTLNTVPVLRKLKESKDHDIKFTEEMIEKLTATPINDLMFALEIVVKPS--SLLVHVPSRSRLDLQATYYILNSVLQ------------------------ POMA_PJVK ------------MFSATAHQVVKSL---GKDSLIPVQSIDVSDNIKPLAILLTERRR-RFFWRRTRYLTTEFCLDDILDEALCKG--ANKDEIVRSRELAK------FDFETNFSLSGKLG--IDLQKEFLDFELDASDNATVKSELGELRKEE-VNLPAFLSLTKER----RINLQHQLVAPLTNDSTRSLCLVTGVVHLAATATLTGQIKESGSESGSCMGSTET--------------GEVSKSKVKKLEVPAGTALAYTVR---------ELLVSTVDGQFRVVLDTSCHGGFVFSLDADVDDVDGP---------------------------------------------------------SSDSLVKASFLHGILSSEIPKDD------------------------LRASLLEILKVPKAIGPLDDLFHEAAVFLETKILKTTLLSILQERIYSLEANLLPFLSLAGFTLQEADVVVYP-----------------------------------------------------TSSSELFEACELLITLLNGLDDDQLSIISACIEETGISQDILCLLRPVWDTDTREVEMPSDSCLLQTDTG------KKLSQAFGFEVTEFLLSLSEDNVRDVQALYLIIFLVVGSSDTQQQ----------------- OCTO_PJVK ------------MFSATISKIVNELG---RDTLHATPSIDEAQKIKLYNIVIKHKKKHFWQADYRLEP-LSSGIETLLKTSES-----KSPDTLQSITRKR------ELGDYTFQVSTNAKGLLGIEVCANGVDIDGDDTTTRSINTAKLEKLY-VTEYELEEALHNR----YIDFENCIVKRMKKKSHEVLCVITGVVYPVSDMKIAKQSTLSEDGKIKTDVKKEIVD--------VDVEEKGSKKNSETVDIVGKTNLAYNIV----------ELKIHPDGTIGVCMTENDKGGFDVVDLCSKGAEKT----------------------------------------------------------LFYPPEEVAAGKNKTELTDSLVD-------------------------CIRYSALFEWLVHWLHVIHSHEHEKLPWDDKFWSFIGDDG--------------FKAASRFFKLINVNFKYG-----------------------------------------------EETSVDGLDQHMLGCALYYLELMSFLSNDEIVAITDCSSTRHVVSSFLKVFSCSLMKKDIGKDIVVPLLEYDWALKLLFCLGYDLSNVKKDSTIKSPKESFKAIEAVGKILYGLFILPLEVNK--------------------- STRONG_PJVK ----MSLFYKHSVFNQATSNFVHSVSSSELSNLIASPSLSDASNCRPYHLVVKTNKKYFWNHVSLFP--TPFTLSDILDNDGAER---FDEVDGTQTDLVN------FERSLIIEAKGKVEA--SLAMEIAGFELDANRHIAVSVDFGQVVEKS-LDIPQLANSVKGR----KINLKKDFIKEVMAKKRNTLCLVVTTLSTEAESKITTELQTSGSADGKFTAGTARSIN---------VETSLSGDRKRTLEIPSNTPLAFRML----------EILVRPDRSIQLMQLPNSEGGFEIIKD-----------------------------------------------------------------------------DKEPTPSR-------------------------------PVPDMEEIRQQLKP-MLLLPEQSLNDARRSLKELLRT-----------------ENSILLNSLNIMVALN--------------------------------------------------------SLLVGHGGKQTTQEILREKLGCSDLNDTKPLLQVAGFSFEIAEALAAERLPLDQPSVSNLFAGSRR--AESLVFSLGFQLERTDGNWYLSYSTSEMVEDDLSPAGLLVIMCALWDQK------------------ ; END;