96 678 tetra_GEb ---------- --MFAAATRS FVEEV--DVG GSLIPVSSPN DG--VSALTV Fugu_GEb ---------- --MFAAATRN FVEEV--EVG GSLIPVSSPN DT--ISVLTV tila_gb ---------- --MFALATRN LVEEV--EDK GSLIPVTSLN DT--IALLTV cod_GSDM_E ---------- --MFATATKN FVEEV--DKD GVLIPVSSLN DS--IKILSL medaka_gEb ---------- --MFALATKN FVDEV--DKK GLLIPVSSRN DD--IHLLTV zfGSDM_Eb ---------- --MFAKATKN LLSEI--DSE GFLIPVLCLN DSDGLSPQAL tetra_GEa ---------- --MFSKATAN FVHQI--DPE GSLIHVSRVN DSKKLVPMAL Fugu_GEa ---------- --MFSKATAN FVHQI--DPE GSLIPVSRVN DSKKLVSMAL medaka_GEa ---------- --MFSNATAN FVRQI--DPN GSLIHVSRLN DSDKLVPMGL zfGSDM_Ea ---------- --MFEIATKK FVRHI--DPS GVLIPASSLN DSKNLQLLAV huGSDM_E ---------- --MFAKATRN FLREV--DAD GDLIAVSNLN DSDKLQLLSL Go_GSDME ---------- --MFAKATRN FLREV--DAD GDLIAVSNLN DSDKLQLLSL cow_gsdmE ---------- --MFAKATRN FLKEV--DAG GNLIAVSNLN DSDKLQLLSL orca_gsdmE ---------- --MFAKATRN FLREV--DAG GNLITVSNLN DSDKLQLLSL seal_gsdme ---------- --MFAKATRN FLKEV--DAG GNLIAVSNLN DSDKLQLLSL pigGSDM_E ---------- --MFAKATKN FLREV--DTG GNLTAVSNLN DSDKLQLLSL moGSDM_E ---------- --MFAKATRN FLKEV--DAG GDLISVSHLN DSDKLQLLSL turkey_gE ---------- --MFAKATRN FVRET--DSG GDLIPVSHLN ASDKLQLLSL chGSDM_E ---------- --MFAKATRN FVRET--DSG GDLIPVSHLN ASDKLQLLSL Flyca_gsdm ---------- --MFAKATKN FVRET--DSG GDLIPVSQLN ASDKLQLLSL turtle_GE ---------- --MFAKATKN FVRET--DCG GDLIPVSRLN DSDKLQLLSL lizard_gE ---------- --MFAKATKN FVKEV--DSG GDLIPVPSLN NLDNLQFLSL coe_GE ---------- --MFAKATCD FLEEI--DYK GDLIAVSSLD DSNKIQLLSL frogGSDM_E ---------- --MFAKATKN FLKDI--DAG GDLIPVYSLN DSDKAHLLGV shark_ge ---------- --MFATATNS FVKQI--DKG GDLIPVRSLN DSDKLQLLSL cod_pjvk ---------- ---------- ---------- ---------- ---------- medaka_pjv ---------- --MFAAATKN FVKQV--GDT GRLIPVPSLS EADHYQPLSL zfPJVK ---------- --MFAAATKN FVKQV--GDT GRLVPVPSLS EADRYQPLSL tila_pjvk ---------- --MFAAATKN FVKQV--GDT GRLIPVPSLS EADRYQPLSL tetrA_PJVK ---------- --MFTAATKN FVRQV--GDT GRLIPVPSLS EADRYQPLSL fugu_PJVK ---------- --MFTAATKN FVRQV--GDT GRLIPVPSLS EADRYQPLSL coe_pjvk ---------- --MFAAATKN FVKQV--DDT GRLIPVPSLS EADRYQPLSL shark_pjvk ---------- --MFSAATKN FVKQV--GDT GRLIPVPSLS EADRYQPLSL huPJVK ---------- --MFAAATKS FVKQV--GDG GRLVPVPSLS EADKYQPLSL Go_pjvk ---------- --MFAAATKS FVKQV--GDG GRLVPVPSLS EADKYQPLSL cow_pjvk ---------- --MFAAATKS FVKQV--GDG GRLVPVPSLS EADKYQPLSL pig_pjvk ---------- --MFAAATKS FVKQV--GDG GRLVPVPSLS EADKYQPLSL seal_pjvk ---------- --MFAAATKS FVKQV--GDG GRLVPVPSLS EADKYQPLSL moPJVK ---------- --MFAAATKS FVKQV--GDG GRLVPVPSLS EADKYQPLSL orca_pvjk ---------- --MFAAATKS FVKQV--GDG GRLVPVPSLS EADKYQPLSL TURKEY_PJV ---------- --MFAAATKN FVKQV--GDG GRLVPVPSLS EADKYQPLSL ch_PJVK ---------- --MFAAATKN FVKQV--GDG GRLVPVPSLS EADKYQPLSL fice_PJVK ---------- --MFAAATKN FVKQV--GDG GRLVPVPSLS EADRYQPLSL turtle_PJV ---------- --MFAAATKN FVKQV--GDG GRLVPVPSLS EADKYQPLSL lizard_pjv ---------- --MFAAATKS FVKQV--GDG GRLIPVRSLS EADKYQPLSL frog_pjvk ---------- --MFSAATKN FVKQV--GDG GRLVPVPSLS EADKYQPLSL Lamp2p_ ---------- ---------- ---------- ---------- ---------- lance_pjvk -------MLQ EEMFEAAVSG FVKAV--GKD -SLLPVPDLN SANKCRPLHV LINGU_PJVK ---------- --MFEAAVTK FVKSV--GQG -SLLPVPSLD EAEKCRPLAV SACCO_PJVK ---------- --MFKSLTDK LSKSL--GED -TLLPVPSLD QADNCRPLSI NEMA_PJVK ---------- MALFESASKQ FVKDT--GRR -SLHAVPDLN SSECCRILCV EXAIP_PJVK ---------- MALFESTSKQ LVKDT--GRS -SLHPIVDLN SASQCKIMCI STYLO_PJVK ---------- MALFEACSKQ FVKDT--GRS -TLRPILDLN TSTRSSILCV ORBI_PJVK ---------- MALFEACAKQ FVKDT--GRS -TLFPVLDLN TSARCDILCV ACRO_PJVK ---------- MAVFECCAKQ FVKDT--GRL -TLRPVVDLN SAIRFDILCV huGSDM_A ---------- MTMFENVTRA LARQL--NPR GDLTPLDSLI DFKRFHPFCL go_GSDMA ---------- MTMFENVTRA LARQL--NPR GDLTPLDSLI DFKRFHPFCL cow_gsdmA ---------- MTMFENVTRA LTRQL--NPR GDLTPLDSLI DFKRFHPFCL pigGSDM_A ---------- MTMFENVTRA LARQL--NPR GDLTPLDSLI DFKRFHPFCL seal_ga2 ---------- MTTFENVTRA LARQL--NPR GDLTPLDSLI DFKRFHPFCL seal_ga1 ---------- MTTFENVTRA LARQL--NPR GDLTPLDSLI DFKRFHPFCL moGSDM_A ---------- MTMFENVTRA LARQL--NPR GDLTPLDSLI DFKRFHPFCL moGSDM_A2 ---------- MSMFEDVTRA LARQL--NPR GDLTPLDSLI DFKRFHPFCL moGSDM_A3 ---------- MPVFEDVTRA LVREL--NPR GDLTPLDSLI DFKHFRPFCL huGSDM_D ---------M GSAFERVVRR VVQEL--DHG GEFIPVTSLQ SSTGFQPYCL Go_GSDMD ---------M GSAFERVVRR VVQEL--DHG GEFIPVTSLQ SSTGFQPYCL cow_gsdmD ---------M ASAFEKVVRS VVREL--DHK -DLTPVDSLW SSTSFQPYTL orca_gsdmD ---------M ASAFARVVRS VVQEL--DHG GELTPVDSLQ SSTSFQLYCL pigGSDM_D ---------M ASAFERVVKS VVREL--DHG RELTPVKSLQ TSDRFQPYCL seal_gsdmD ---------M ASAFESVIKS VVREL--DHS GELIPVDSLR SSTSFQPYYL moGSDM_D ---------M PSAFEKVVKN VIKEVS-GSR GDLIPVDSLR NSTSFRPYCL huGSDM_C ---------M PSMLERISKN LVKEI---GS KDLTPVKYLL SATKLRQFVI Go_GSDMC ---------M PSMLERISKN LVKEI---GS KDLTPVKYLL SATKLRQFVI cow_gsdmC ---------M PSLFEHTSKN LVKEL---GD KDFRPLQNLL SAHKFCQLKL orca_gsdmC ---------M PSLFEPISKN LVKEL---GD KDLRPVKYML STSKFHQLAL pigGSDM_C ---------M ASLFERVSKN LVKEL---GD KDLKPVKSPL DTNKFRQFAL moGSDM_C3 ---------M GYSFDRASKD VVKKL---QG RDLRPVECLS DATKFRLFHI moGSDM_C2 ---------M GYSFDRASKD VVKKL---QG RDLRPVECLS DATKFRLFHI moGSDM_C4 ---------M GYSFDRASKD VVKKL---QG RDLRPVECLS DATKFRLFHI moGSDM_C ---------M SYTFDWLSKD VVKKL---QG RDLRPVKCLS DATKFCLFNI huGSDM_B ---------M FSVFEEITRI VVKEM--DAG GDMIAVRSLV DADRFRCFHL Go_GSDMB ---------M FSVFEEITRI VVKEM--DAG GDMIAVRSLV DADRFRCFHL seal_gsdmB ---------M WSVFEEITGV VVQEM--DAG GDMIAVRSIL DADRFHCCSL cow_gsdmB ---------M PTVFESISRA VVKEI--DTS GETIAVRSLS DADKFHCSYL orca_gsdmB ---------M LAVFEKIARA VVQHM--DAG GDMIAVRSLI DADRFHCFYP pigGSDM_B ---------M PKEFEAATRA VVREV--DPQ GDWIAVRSLT DADRFHCLYL turkey_GA2 ---------- --MFKKITQK VAKQM--DPK GDLVPVHSIS DQDHFRLLCL chGSDM_A ---------- --MFKKVTQK VAKQM--DPK GELVPVHSIS DQDHFRLLCL flyca_gsdm ---------- --MFKNVTKF IVNQM--DPC KELVPVESIA DNEHFRPLYL lizard_gA1 MKEKGQNYLP EMSFHKTTKS LAKKL--NPE GDLIPVRSII DNDHYRPLCL turtle_GA ---------- --MFYKVTKQ LVKQL--VPD GDLLPVCNLI DQDHFRPLCL LOTT_JVK ---------- --MFSATAHQ VAKAL---GK ETLLPVPSIN TADNIEILRI POMA_PJVK ---------- --MFSATAHQ VVKSL---GK DSLIPVQSID VSDNIKPLAI HYDRA_PJVK ---------- MAMFEAATKC IAKSI---GS KTLHHVSDLN SSERFKLLCV STRONG_PJV ----MSLFYK HSVFNQATSN FVHSVSSSEL SNLIASPSLS DASNCRPYHL OCTO_PJVK ---------- --MFSATISK IVNELG---R DTLHATPSID EAQKIKLYNI VVKRKRLWFW QKPKYTP--T DFKLNDLL-T GNPP---IKP DVSESDFIKY VVERKRLWFW QKPKYTP--T DFKLNDIL-T GEPP---IKP GIAEIDFLKY VVKRRRFWCW QKSKYLP--T DFNLNDIL-T GDTP---INP VVVETDFIKY VIKRRRYWFW QKPKYLA--T DFCFNDIL-K GDQP---ILP VLTETDFIKY VVKHNRFWFW KKPNYVP--T DFTLNDVL-T GDNP---IKA EVTETDFLNY VIKRNRYWFW QQPKYKP--T DFKLSDVL-V GD-P---INP VVVETEFLTY VVKRNRPWFW QKPKYHP--T DFTLSDLL-Q GDEV---LCP EVSETEFLTY VVKRNRRWFW QRPKYYP--T DFTLSHLL-Q GDKD---LHP EVSETEFLTY VVKRNRIWAW QRPKYRP--T DFILSDLL-Q GDLK---LEP GVSQMDFLTY VLKSKKRWFW QRIKYRP--T EFTLNNLLKE KKTQ---LKP EYKKEEFVKY VTKKKRFWCW QRPKYQF--L SLTLGDVL-I EDQF---PSP VVVESDFVKY VTKKKRFWCW QRPKYQF--L SLTLGDVL-I EDQF---PSP VVVESDFVKY VTKKKRYWCW QRPKYQF--L SVTLGDVL-T EDQF---LSP VVVESDFVKY VTKKKRLWCW QRPKYQF--L SVTLGDVL-T EDQF---LSP VVVESDFVKY VTKKKRFWCW QRPKYQF--L SVTLGDVL-T EDQF---LSP VVVESDFVKY VTKKRRFWCW QKPKYQF--L SVTLGDVL-T EDQI---LSP VVVESDFVKY VTKKKRYWCW QRPKYQI--L SATLEDVL-T EGHC---LSP VVVESDFVKY VTKRKKFWCW QKPKYHF--L AVSLSDVL-T EDKP---IKP VIVESDFAKY VTKRKKFWCW QKPKYHF--L AVSLSDVL-T EDKP---IKP VIVESDFARY VTKRRKFWCW QKPKYHF--L TVTLSDVL-T EDKP---IKP VIVESDFAKY VTKKKKLWCW QKPKYHF--L TVTLNDVL-T EDKP---IKP VVFESDFVKY VTKKKKTWCW QKPKYYL--L SVTLNDVL-A KGEP---IEP VVAESDFVKY VTKRPSFWFW KKPKYHS--S PFTLSDVL-V GSRP---IKP VVVESDFLKY VAKTRRFWCW QKPKYHFSSC SCTLSDIM-T EDKE---IKP VVVESEFVKY ATKRKMRWFW QKPKYHS--S SFNLEDIL-T GDVH---IKP AVKESNFLKY ---------- ---------- ---------- ---------- ---------- VTRKRKKHFW QKNKFSS--T SFSLKDIL-V GEKE---ITA ---------- VTRKKKRHFW KKTKYAT--T PFSLKDIL-V GEKE---ITA GVSSYQLLNY VTRKRKRHFW KKDKYAS--T PFSLKDIL-V GEKE---ITA GVSSYQLLNY VTRRRKRSFL KKRGFAS--T PFSLKDIL-V GEKE---IQA GVSSYQLLNY VTKKRKRRFF KKRSFAS--T PFSLKDIL-V GEKE---IKA GVSSYQLLNY VTKKKKPHFW KKTKYAS--T PFTLKDIL-V GEKD---ISA GVSSYQLLNY VTKKKKSCFW KKNKYSS--T PFTLKDIL-V GEKE---VSA GVSSYQLLNY VVKKKRCFLF PRYKFTS--T PFTLKDIL-L GDRE---ISA GISSYQLLNY VVKKKRCFLF PRYKFTS--T PFTLKDIL-L GDRE---ISA GISSYQLLNY VVKKKRCFLF PRYKFTS--T PFTLKDIL-L GNRE---ISA GISSYQLLNY VVKKKRCFLF PRYKFTS--T PFTLKDIL-L GDRE---ISA GISSYQLLNY VVKKKRCFLF PRYKFTS--T PFTLKDIL-L GDRE---ISA GISSYQLLNY VVKKKRCFLF PRCKFTS--T PFTLKDIL-L GDRE---ISA GISSYQLLNY VVKKKRCFLF PRYKFTS--T PFTLKDIL-L GDRE---ISA GVSSYQLLNY VIKKRKCLLS KKSKFAS--T PFTLKDIL-E GEKE---ISA GVSSYQLLNY VIKKRKCLLS KKSKFAS--T PFTLKDIL-E GEKE---ISA GVSSYQLLNY VIKKRKCSLS KKSKFAS--T PFTLKDIL-Q GEKE---ISA GVSSYQLLNY VIKKKKCFLS RKSKFAS--T PFTLKDIL-Q GEKE---ISA GVSSYQLLNY VIKKKSCIFS RRSRFIS--T PFSLKDIL-Q GEKE---ISA GISSYQLLNY VIKKKKCFLS RKFKYIS--T PFTLKDIL-N GDKE---LSA GVSSYQLLNY ---------- ----MTS--R ---------- ---------T HVTSYQLVNY AVKKNPKWFW QSAKYLP--T SFKIHQILTK TEEI---DVN VACRTLVE-Y VIKKKRRWFW QCSKCEP--T PFFLHELLTD ETTL---GLK SETRDLVT-Y VVKKNRRWFW RAPKYLP--S QYTLSQLLSN KEDL---DVP IINEDLTN-F IERKKSRWFW RSTKYLT--T PFVLNELLTE PVDL---KEK QKEEVFITDY IEKKKSRWFW RPTKYLP--T PFTLNELMTK PIDS---K-K IKTSEFVSNY VTKKRSRWFW KTDTYKS--T PFTLNELLTK PVHI---KGH IEKSTFISNY VTKKRSRWLW KSDKYKT--T PFSLNELLTK PVDI---SGQ IKKSVFIANY VIKKRSRWIW KSVKYEA--T PFTLNEILTK PVDC---VSK SEKSVFIRNY VLRKRK--ST LFWGARYVRT DYTLLDVLEP GSS------- --PSDPTDTG VLRKRK--ST LFWGARYVRT DYTLLDVLEP GSS------- --PSDPTDTG VLRKRK--ST LFWGARYVCT DYTFLDILEP GSS------- --PSDPTDSG VLRKRK--ST LFWGARYIRT DYTLLDVLEP GSS------- --PSDPTDSG VLRKRK--ST LFWGARYVRT DYTLLDVLEA GSS------- --PSDPTDSG VLRKRK--ST LFWGARYVRT DYTLLDVLEA GSS------- --PSDPTDSG VLRKRK--ST LFWGARYVHT DYTLLDVLEP GSS------- --PSDPTDSG VLRKRK--ST LFWGARYVRT DYTLLDVLEP GSS------- --PSDPTLLG VLRKRK--ST LFWGARYVRT DYTLLDLLEP GSS------- --PSDLTDSG VVRKPS--SS WFWKPRYKCV NLSIKDILEP DAA------- --EPDVQRGR VVRKPS--SS WFWKPRYKCV NLSIKDILEP DAP------- --EPDVQRGR LSRKPL--SS RFWRPRYKCV NLSIRDILEP DAP------- --EPALECGR LGRKSS--SS RFWKHRYTRV NLSIRDILEP DAP------- --EPAVECGN LGRKPS--SS WFWRPRYTCV DLSIWDILEP SAP------- --EPAVERGG LGRKLS--RS WFWKPRYKSI NLSIRD-LEP DTP------- --EPAVKQSA LNRKFS--SS RFWKPRYSCV NLSIKDILEP SAP------- --EPEPECFG LRKKKDSRSS FWEQSDYVPV EFSLNDILEP SSS------- --VLETVVTG LRKKKDSRSS FWEQSDYVPV EFSLNDILEP SSS------- --VPETVVTG LRKKRRTLSQ FWEQPD-VPV DHTLTDILEP SPS------- --VPEPVLSK LWKKKGTHAQ FWGQPA-VPV EYTXVDILEP SSS------- --VPV----- LRKKRKTRTE FWEKPD-VSA ECSLMDILEP SSL------- --VPETVVTG LQETP---RS GWETED-IPV GFTLLDLLEP NFP------- --VPEPEVSA LQETP---RS GWETED-IPV GFTLLDLLEP NFP------- --VPEPEVSA LQETP---RS GWETED-IPV GFTLLDLLEP NFP------- --VPEPEVSA LQETSS--RL ALKTEY-IPV GFTLLHLLEP NIP------- --VPEPEVSA VGEKRT---- -FFGCRHYTT GLTLMDILD- TDGD---KWL DELDSGLQGQ VGEKRT---- -FFGCRHYTT GLTLMDILD- TDGD---KWL DELDSGLQGQ VRGRRN---- -FWGHQYHRT DLTLEDIER- GKGK---GLF DKLGSGPQGQ VKKRRR---- -FFGYQYDKT NLTLKDILEC EVP------F DMVVPELQGQ VKERRR---- -FFGYQYDKR DLTLXDILEM DKGE---GLF DKLVPGLQGQ VKKKKR---- -FFGHQYDKA DLRLVDILEV QEGD---ELF DKLVSGLQDH VRRKRKAR-- FRPFPSYRRT EYRLHDVLLP GEE------- KDSVESLLPS VRRKRTAR-- FQPSPSYRRT EYSLHDVLLP AEE------- RDSVESLLPS LKRKRKPKTI FHPAPYYQRT GFTLHDVLLP GED------- GKSIESLHQD LYRKANSS-- WWKTKSFRKS EYKLTDVLCF GDH------- AIKLDVKDGG VRRKPKKA-- FCRTLHYAKT GFRLWDILVP GED------- STHLDVQDSG VIKKRRKWLF FTRKPHYETT EFTLSDVLLG EHQK---EFE VLPLDTHVLT LLTERRR-RF FWRRTRYLTT EFCLDDILDE ALCKGANKDE IVRSRELAKF VCQKKSFWPW KKTQIFP--T QIVLQDILLT KLNIE---QS DVNFTLVKDY VVKTNKKYFW NHVSLFP--T PFTLSDILDN DGAER-FDEV DGTQTDLVN- VIKHKKKHFW QADYRLEP-L SSGIETLLKT SESK----SP DTLQSITRKR T-------GT YGDKIQGNVD --ASFSPLQA SVALEGNDSS KLQASFGGLR T-------GT YGENIEGNVG --ANFSPLQS SVTLEGKDSS KLHMSFGSLK S-------GT FSDKIQGTVD --ANFS--KY SVKLQGEDSS KLQSSFGSLK N-------GR FSDNMQGNIE --ANLH--SA NLSVEGKDSS KLRSAFGSLK S-------GT FSDLTQASVN --AELSN-AG GRSVTGKGSS TLKSSFGDLK K-------GK VMDTKSGSAV --AELG--PG TINIGGSGSS KLQSSFGNLK N-------GT FGDKLSGKLD --TDAG--PV SVILEGRGSS KLQSSFGKLK Q-------GT FGDNLSGKLD --TEAG--TV SIVLKGQGSS KLRSFFGKLK K-------GT YIDKKSAMLD --VRAG--GA NAGLEGQGAS KLHSSFDNLK M-------ET NRNVLGGSVD --VSGP--DV TLNLNGRSIS NLYLRLGRLQ E-------GK FANHVSGTLE --TALG--KV KLNLGGSSRV ESQSSFGTLR E-------GK FANHVSGTLE --TALG--KV KLNLGGSSRV ESQSSFGTLR E-------GK FENHVSGTLE --TALG--KV KLNIGGKGLV ESQSSFGTLR E-------GK FENHVSGTLE --TALG--KV KLNIGGKGLV ESQSSFGTLR E-------SK FQNHVSGTIE --TALG--KV KMNVGGKGLV ESQSSFGNLR E-------GR FENHTRGALK --TALG--KA KLTLGGKGFV ESQSSFGTLR E-------SK CENHKSGAIG --TVVG--KV KLNVGGKGVV ESHSSFGTLR M-------GK FEDVVQGSIE --TSFG--KI SLGAGAKGCV ESQSSFGNLR M-------GK FEDVVQGSIE --TSFG--KI SLGAGAKGCV ESQSSFGSLR M-------GK FEDFVQGSIE --TSFL--KI SLGTGGKGYV ENQSSFGNLR E-------GK FEDFVRGSIE --TSFG--KI NLGAGGKGFV ESQSSFGNLR E-------GK FEDYVTGSIE --TSFG--RI NLGAGGRGVV KSQSSFGNLK E-------SK SGNTEKGTIG --ASVG--IG NLVVGGNESV ELQSSFGTVR E-------GT FGDVIKGNIG --AEVG--AL QMNASGCGYV ESQSSFGTLR E-------GI FENSVGGAMN --TLIA--DI SFHIEGQNSI ALESSFGKLR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-------DK SDVALNGRL- --GNHLIHEV GVNVSGSDSV AVKASFGIVT E-------DK SDVALNGRL- --GNHIINDV GFNISGSDSV AVKASFGIVT E-------DK SDLMLNGRS- --GNQLINDV GLNLSGSDSV AVKASFGIVT E-------DK SDLMLNGRS- --GNHLSNDV GLNLSGSDSV AVKASFGIVT E-------DK SDVSLTGRL- --GNQIINDV GFNIAGSDTV AVKASFGIVT E-------DK SDVSLNGRL- --GNQVIHDV GFKIAGSDSV AVKASFGIVT E-------DE SDVSLYGRR- --GNHIVNDV GINVAGSDSI AVKASFGIVT E-------DE SDVSLYGRR- --GNHIVNDV GINVAGSDSI AVKASFGIVT E-------DE SDVSLYGRR- --GNHIVSDV GINVTGSDSI AVKASFGVVT E-------DE SDVSLYGRR- --GNHIVNDV GINVTGSDSI AVKASFGIVT E-------DE SDVSFYGRR- --GNHIVNDV GINVTGSDSV AVKASFGVVT E-------DE SDVSLYGRR- --SNHIVNDV GINVTGSDSI AVKASFGVVT E-------DE SDVSLYGRR- --GNHIVNDV GINVTGSDSV AVKASFGVVT E-------DK SDVSLNGRR- --GNQIINDV GFDVAGSDSI AFKASFGIVT E-------DK SDVSLNGRR- --GNQIINDV GFDVAGSDSI AFKASFGIVT E-------DK SDVSLNGKR- --GNQIMNDV GFDVAGSDSV AFKASFGIVT E-------DK SDVSLYGRR- --GNQIMSDV GVNMAGSDSI AVKASFGIVT E-------DK SDVALNGRR- --GNHIMSSA GVNIAGSDSL AVKASFGIVT E-------DK SDLSLNGRH- --GNQIRNDV GINIYGSDSV AVKASFGIVT E-------DE SDGAPGRRER HGSEGVLAGV GFSVARSENV AVHASLGIVT N-------KT SHFSVKGSVG ---SKIMKEV DLDVSGSGMV SIKASFGKVN N-------RT SRFSAKGSIG ---AKLKVLF DVELSGSDTV LVEAKFGDVT D-------DV SSFSVKGKIG ---AKIASEV DLDVKASDDI QMSSKLGQIV Q-------NN PQFHVSGKLG ---AKIAKDL GIDVSTTDSF VVKMNIGAVN S-------NQ PTLHVSGKLG ---GKIAKEL GIDVSTADSF VVKMDLGSIN K-------NE PKFHISGKLG ---GKIASEF GIDASAVDSF TISMDVGTVL K-------NE PKFHVSGKLG ---AKIATEF GIDVSAIDSF TISMDVGDVI K-------NE PEFNVKGKLG ---GKLAQYF GIDASCIDSF TVDMNVGTVT N-------FG FKNMLDTRVE G--DVDVPKT VKVKGTAGLS QNS--TLEVQ N-------FG FKNMLDTRVE G--DVDVPKT VKVKGTAGLS QNS--TLEVQ N-------FG FKNMLDARVE G--EVDVPKT VKVKGTAGLS RNS--TLEVQ N-------FG FKNMLDARVE G--EVDVPKT VKVTGTAGLS QNS--TLEVQ N-------FS FKNMLDARVE G--EVDVPKT VKVTGTAGLS RSS--TLEVQ N-------FS FKNMLDARVE G--EVDVPKT VKVTGTAGLS RSS--TLEVQ N-------FS FKNMLDARVE G--DVDVPKT VKVKGTAGLS RSS--TLEVQ N-------FS FKNMLDVRVE G--DVEVPTM MKVKGTVGLS QSS--TLEVQ N-------FS FKNMLDVQVQ G--LVEVPKT VKVKGTAGLS QSS--TLEVQ S-------FH FYDAMDGQIQ GSVELAAPGQ AKIAGGAAVS DSSSTSMNVY S-------FH FYDAMDGQIQ GSVELAAPGQ AKIAGGAAVS DSSSTSMNVY T-------FQ FHDAMDGQLQ GSVKLAAPGQ GRLSGGAAVS GSSSASMDLC T-------FH FHDAMDGKMQ GSVELAAPGQ GKLSGGAAVS GSSSASMIVC P-------FY FHDTMDGQLQ GQVELAAPGQ GKFSGGAAVS GSSSASMNVC P-------IH IYDSMDGELQ GSGELEAPGQ GRFAGGAAVF DNFSISMNVR S-------FK VSDVVDGNIQ GRVMLSGMGE GKISGGAAVS DSSSASMNVC P-------FH FSDIMIQKHK ADMGVNVGIE VSVSGEASVD HGC--SLEFQ P-------FH FSDIMIQKHK ADMGVNVGIE VSVSGEASVD HGC--SLEFQ K-------FI FIDKTVWKGA AEVDVTAGLE VSVSGTATQS CEC--SLEVQ ---------- ---------- ---------- ---------- ---------- P-------FH FKDKVIAMES VHMDVTAGLE VSVLGEAAQS HGS--SLEFR P-------KP FIHVQSTDLE ANLNVADIAR GGVG--YVGY GGY--NIEVQ P-------KP FIHVQSTDLE ANLNVADIAR GGVG--YVGY GGY--NIEVQ P-------KP FIHVQSTDLE ANLNVADIAR GGVG--YVGY GGY--NIEVQ P-------IP LKHTISQKLK ADLDVETIAG GEAG--FVKS CGY--DIEVQ K-------AE FQILDNVDST GELIVRLPKE ITISGSFQGF H--HQKIKIS K-------AE FQILDNVDST GELIVRLPKE ITISGSFQGF H--HQKIKIS K-------AE FQVLDMVDSK GMLTVKLPKE ITTVGAFHRS H--KQRVKIL G-------DN FEILDVVDSK GSLAVKFHPQ MTFKIAFHIF Q--EKNIKLE E-------VK SQVMDSVDSK GSLTVKLPKE KTLDMGITFS RSPEQGIELS K-------AP FRVTDNVDSK GGLTVKLPEN MMFEVATYRS R--KCNAEVS TDGHSPRQFT TTGSVRDSVD GTLSIPTEPA EVELGGAASV SKQW-HIKLE TDSHSPREFT TTGSTKDRVD GTLSIPIDRA EVELGGAAST AKQW-HVKLE S-----CQIT ITKASKDQAD GGLSISCDPA SVDLQGGGSL SKEF-SITPQ Q-------FD IEDRVDGTLQ GEFSG-RDIA PIEAKTNSII THVM-SVKVK P-------IT VVDCVDGTLK GSVKVPVDFG RMEAMGAAST YQVK-SIKMK AYN-----SK SNLSLKGKFG --ADLTKELL DVKLGSTDSV VVSSQLGVLN D-------FE TNFSLSGKLG --IDLQKEFL DFELDASDNA TVKSELGELR -------IEN PTLNIKGDVG ---AKIASEL QLEFSASDSV SLNINVGSLQ --------FE RSLIIEAKGK VEASLAMEIA GFELDANRHI AVSVDFGQVV E------LGD YTFQVSTNAK GLLGIEVCAN GVDIDGDDTT TRSINTAKLE KEEVDMQKLL HDCKD----R ILDMSHCLIL QAKDKPRRAF GIVKERIVTA KEEVDMQELL RDCKG----R LLDMSHCLIL QTKDKPRRTF GIVKERIVTT KEEMDMQKLL RDLKD----K VLDMSHCLIQ QTKEKQRRVF GIVKDRIITT KEELDLQ--- ---------R VLDMSHSLIQ QTKEKRREVF GVVKERIVTT KEEVELQKLL HDLKDSHWHR ALDMSHVLIR QTMKKHKTVL GIVKERILTT KQELDLQKLL HDSKS----R VLDMQHSLIQ QTRNAKTEVL AVVKERIITT KQELDVTKLL RDSAD----R QVDMQHVLVQ QLK-KRDDVL AVVKERVLTT KEELDVTKLL QDSKD----R QVDMQHMLVQ QLK-RQDVAL AVVKERIITT KEELDVRKLL SDSSN----R LVDMHHVLVQ QLE-KRADVL AVVKERILTT KEYLDIPKLL NDTRG----R KLDLKHSLIK QSK-NKNKTF AILKERIFTT KQEVDLQQLI RDSAER---- TINLRNPVLQ QVLEGRNEVL CVLTQKITTM KQEVDLQQLI RDSAER---- TINLRNPVLQ QVLEGRNEVL CVLTQKITMM KQEVDLQQLI GDAQER---- TINLKNPVLQ QVLERKNAVL CVLTQKIVTT KQEVDLQQLI GVAQER---- TINLKNSVLQ QVLERKNEVL CVLTQKIVTT KQEVDLQQLI RDSTERXXEF SINLRDPMLQ QVLERKNEVL CVLTQKIVTT KQEVDLQQLI RDAQGR---- TIDLKNPVLQ QVLERKNEVL CVLTQKIVTT KQEVDVQQLI QDAVKR---- TVNMDNLVLQ QVLESRNEVL CVLTQKIMTT KQEVDLQQLM KDVKDR---- MINLNSSLLQ QVIERKREVL CILREKIITT KQEVDLQQLM KDVKDR---- MINLNSSLLQ QVIERKREVL CILREKIITT KQEIDLQQLM KDVKDR---- TIDLKSSLLQ QVIERKREVL CILREKIITT KQEADLQQLM KDTRGR---- TINLNSNLLQ QILERKHEVL CILTEKIVTT KQEADLQHLL KDVKGR---- AINIQHTLLQ QMLERKHEVL CILTERIVTT KQEVDVHQLL KDAQER---- TIDLNDRFVQ QTRERK-EVL CMIREKLVTT KQEVDMQHLM KDVHDR---- RINLHHPFIK QLQENKNDVL CILKEKIVTT KQEVDLHQVL KISQER---- TINMRHSLVQ QTRERGDEVL CVVNEKIITT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KHEVEVPTLL RELNAR---- KVDLDHCLIR QSKESGRTVL CVVMESIRTT KHELEVPTLL RELNSR---- KVDLDHCLIR QSKESGRSVL CVVVESIRTT KHELEVPSLL RELSSR---- KVDLDHCLVR QSKERGRSVL CVVVESIRTT KHELEVPSLL RELSSR---- KVDLDHCLVR QSKESGRSVL CVVVESIRTT KHEVEVPTLL RELSTR---- KVDMEHCLIR QSKESGRAVL CVVMESIRTT KHEVEVPALL REIN-R---- KVDLEHCLVR QMKESRRAVL CIVMESIRTT KHEVEVSTLL KEITTR---- KINFDHSLIR QSRSSRKAVL CVVMESIRTT KHEVEVSTLL KEITTR---- KINFDHSLIR QSRSSRKAVL CVVMESIRTT KHEVEVSTLL KEITTR---- KINFDHSLIR QSRSSRKAVL CVVMESIRTT KHEVEVSTLL KEITTR---- KINFDHSLIR QSRSSRKAVL CVVMESIRTT KHEVEVSTLL KEITTR---- KINFDHSLIR QTRSSRKAVL CVVMESIRTT KHEVEVSTLL KEITAR---- KINFDHSLIR QSRSSRKAVL CVVMESIRTT KHEVEVSTLL KEITTR---- KINFDHSLIR QSRRSRKAVL CVVMESIRTT KHEVEVPMLL KELTTR---- KINFDHCLVH QTRKSRMEIL CVVMESIRTT KHEVEVPTLL KELTTR---- KINFDHCLVH QTRKSRMEIL CVVMESIRTT KHEVEVPTLL KELTTR---- KINFDHCLVH QSRKSRMEVL CVVMESIRTT KHEVEVPTLL KELTSR---- KINFDHCLVR QSRESRKEVL CVVMESIRTT KHEVEVPTLL REMANR---- KMNFEHCLVR QSRESKRTVL CVVMESIRTT KHEVEVPALL KELLSR---- TIDLDHCLTH QAKESGKEVL CVVMESIRTT KHELDVPLLL RLLRNR---- RVDVEHWLVR QTRASGRAVL CVVAESIRTT KCDVDVPTLM QALDKR---- FVDFRHDFVQ EVRQNPRNVL CVVVGTACTI KEEVDVPTLL DVLSHR---- NLQLDHEFIK QVQENPRKVL CVITGTAVTT KNKVNIPILQ DLLTRK---- KLNLTHPFIE EIRQNYRNVL CVVVGSLCTT KTEIRWQDMF SALKGK---- RLNVDHEFVQ AIIASKRRSL SVVCEMLATT KSEIRWQDLN DALKDQ---- TLKLDHEFVQ AILNCRRRSL CIVFETLNTT KREVTWVNLK KALADT---- TLNLGHEYVQ YICTKQRRSL CIIYETVATQ KKQVHWGNLN DALADI---- TLNLDHEYVQ YILSKPRRSL CVIYETVATH KREVKWDVLN QLLADN---- TLNVDHEFVQ TILGKPRRSL CIVYETVSTG TLSVAPKALE TVQ-ER---- KLA-ADHPFL KEMQDQGENL YVVMEVVETV TLSVAPKALE TLR-ER---- KLA-ADHPFL KEMQDQGENL YVVMEVVETV TLSVAPKALE TLHQER---- KLM-AEHPFL EEMRRRGENL YVVMEVVEAV TLSVAPKALE TLHQER---- KLM-AEHPFL KEMRSRGENL YVVMEVVETV TLSVAPKVLE TLHQER---- KLS-AEHPFL KEMRDRGENL YVVMEVVETV TLSVAPKVLE TLHQER---- KLS-AEHPFL KEMRDRGENL YVVMEVVETV TLSVAPTALE NLHKER---- KLS-ADHPFL KEMRERGENL YVVMEVVETL MLSVAPTALE NLHMER---- KLS-ADHPFL KEMREYKQNL YVVMEVVKAK TLSVAPSALE NLKKER---- KLS-ADHSFL NEMRYHEKNL YVVMEAVEAK SLSVDPNTWQ TLLHER---- HLRQPEHKVL QQLRSRGDNV YVVTEVLQTQ SLSVDPNTWQ TLLHER---- HLRQPEHKVL QQLRSRGDNV YVVTEVLQTQ TLRVTPNTWE AMHHER---- RLRQPEPKTL QQLRSRGDDV FVVTEVLQTQ TLRVAPNTWE AMHRER---- RLRRPEHKVL QQLRNRGDDV FVVTEVLQTQ TLRVAPNTWD AMHLER---- RLRQPEHKVL QQLRSRGNDV FVVTEVLQTQ TLQVDPNIWD AMKQER---- RLRQPEHKVL QQLRNCGNDV FVVTEVLQTQ ILRVTQKTWE TMQHER---- HLQQPENKIL QQLRSRGDDL FVVTEVLQTK IVTIPSPNLE DFQKRK---- LLD-PEPSFL KECRRRGDNL YVVTEAVELI IVTIPSPNLE DFQKRK---- LLD-PEPSFL KECRRRGDNL YVVTEAVELI SVTISPWDWE DLQKRK---- VLD-QEPSFL QECRTRGDNL YVVTEAVKLV ---------- ---------- ---------- ---------- ---------- SVAIPPTTWE GLQKRK---- VLE-KK---L VKYRDAGQNL YVVTEAVELI STSIPNPKLE ILQNRK---- LLD-KLPTFM KFCRMERKNL YVVTEAYEVS STSIPNPKLE ILQNRK---- LLD-NLPTFM KFCRMERKNL YVVTEAYEVS STSIPNPKLE ILQNRK---- LLD-KLPTFM KFCRMERKNL YVVTEAYEVS SKSIPNPKLE SLQNRK---- LLD-QLPTFM KTCWKDGKNL YVVTEAYEVT ENRISQQYLA TLENRK---- LKR-ELPFSF RSIN-TRENL YLVTETLETV ENRISQQYLA TLENRK---- LKR-ELPFSF RSIN-TRENL YLVTETLETV EPRIPQQYLD SLEHWE---- LRR-RLPTLL QSIWRMRADL YLVTEILEMA KSEIPQEFLD SLKNKK---- LKK-ELPPSF QSIQAKREDL YLVTETLKTK KTWILQKFLD SLKNKK---- LKR-KLTPMF QSIQAMREDL YLVTETLKTT GSRTPRQLLA ALENTK---- LKR-KLPDSF QSIRAMREDL YLVTETLTTT KKHILVPKLE ALREE----- RKINMKHTFI EQLRKARQNL YVIHETIETS KKHILVPKLE ALREK----- RKINMKHTFI EQLRKVRQNL YVIHETIETS KKSISLQSLE ALRRE----- REINMDHSFI QQLRRTDINL YVVTEILEAS KIQLCPTILN SVKKVF---- RKINMDHEFI KQSKKHDYNL YIVTEAIEAV KVHVSPANLE LLKKE----- RKINMNSSFI KQLRESRENL YVIYEAVQAL KTEISTPKLL HLLEKK---- KIDLHHPLIS VVKDNGHKTL CIITSIIHLK KEEVNLPAFL SLTKER---- RINLQHQLVA PLTNDSTRSL CLVTGVVHLA KQEIKWQKLD NALQSS---- KVNTRHPLLE EIQFLKRTEL AVVLESISTC EKSLDIPQLA NSVKGR---- KINLKKDFIK EVMAKKRNTL CLVVTTLSTE KLYVTEYELE EALHNR---- YIDFENCIVK RMKKKSHEVL CVITGVVYPV QPCSVVEEVQ QGGQCGAGLS LCGPST---- -PKVFLKDNA SLLKDSNVTM QPCSVIEEVQ QGGQCGGGLS LCGLAK---- -PKVFLKDNA YLMKDSNVTM QPCSVIEEVQ QGGQCGGSLS TCGPKI---- -TKFLLKENA SLGNDSDITM QPSSVIEEVQ QTGALGGLLS LCG------- -PKVSFKENA NLAKDSNVTM TLSSVVEEEE RSGQCAGSLS FFGSLS---- -KKVSLKDNT NLTKDSNVTI QPCTITEEVQ EGGSCTGMFG FNKTIK---- -VSSNDKGKP SIAYDTDVSI SSCSVTLIKK DQCTLRGVLR LMGMLHLGNS PVKVCVKENT NFEADSDVSL SSCSVTMTKK NQCTVLGMLG LMSMLG---S SVKVCVKDSA NIEADSDISL SPCSVTLRRK QQCGFHGVLS LLSLLG---- -SSRNEKKKN NVEMNSDVSL CNGKINWNEE EKSGCQTVFT VFWN------ --KMSIEGSG KQHHGSETKL QKCVISEHMQ VEEKCGGIVG IQTKT----- -VQVSATEDG NVTKDSNVVL QKCVISEHTQ VEEKCGGIVG IQTKT----- -VQVSATEDG NVTKDSNVVL QKCVISEHVQ IEETCGGMVG IQTRT----- -VQVSAMEDG NIIKDTNVVL RKCVISEHVQ IEEKCGGMVG IQTKT----- -VQVSATEDG NIIKDSNVVL QPCVISERVQ IEERCGGVVG IQTKT----- -VQVSAKEDG NIVKDTNVVL QQCVISEHVQ MEK-CG-VVG IQLKT----- -VQVSVMDRG NISKGSNVVL QKCVISEHVQ SEETCGGMVG IQTKT----- -IQVSATEDG TVTTDTNVVL QRCTISEHIQ TEEKVSGLLG CSMKI----- -VQVSVSDSG SMMKDSSVIL QRCTISEHIQ TEEKVSGLLG CTTKI----- -VKVSVSDSG SMMKDSSVIL QRCTISEHIQ TEEKVSGVVG CTAKT----- -IKVSVSEDG SLVKDSSVIL QKCLVSEHIQ TEEKCGSVVG FSTKI----- -IKVSVSENG NVRKDSNVVL QKCLISEHVQ TEEKIASMVG ISTKV----- -IKVSVSEDG NVIKDSNVIL QKCSLLEHIQ EEESCGGALA FKSKR----- -IQVSLNENG KLQKDTNVVL QKCIITEHTQ TEETFKGKVS MKAKI----- -VKVSVSENG NYLKDENTIL QQCFISEHLQ IAEKCGGMFG LKIKM----- -LKVSANNDG SLSK--EIVL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RQCSLTV--- -------HAG VRGTTM---- ---RFQIDDG RNPKGRDKAI RQCSLTV--- -------HAG MRGTTM---- ---RFQIDDG RNPKGRDKAI RQCSLSV--- -------HAG MRGATM---- ---RFQIDNS RNPGGRDKAI RQCSLSV--- -------HAG MRGATM---- ---RFQIDNG RNPRGRDKAI RQCSLTV--- -------HAG VRGKTM---- ---RFQIDDG RNHKGRDKAI RQCSLTV--- -------HAG MRRKTM---- ---RFQIDDG RNHKGRDKAI RQCSLSV--- -------HAG IRGEAM---- ---RFHFMDE QNPKGRDKAI RQCSLSV--- -------HAG IRGEAM---- ---RFHFMDE QNPKGRDKAI RQCSLSV--- -------HAG IRGEAM---- ---RFHFMDE QNPKGRDKAI RQCSLSV--- -------HAG IRGEAM---- ---RFHFMDE QNPKGRDKAI RQCSLSV--- -------HAG IRGEAM---- ---RFHFTDE QNPKGRDKAI RQCSLSV--- -------HAG IRGEAM---- ---RFHFMDE QNPKGREKAI RQCSLSV--- -------HAG IRGESM---- ---RFHFMDE QNTRGRDKAI RQCSLTV--- -------HTG MRGETM---- ---RFHIIED QNNKGRDKAI RQCSLTV--- -------HTG MRGETM---- ---RFHIIED QNNKGRDKAI RQCSLTV--- -------HTG MRGETM---- ---RFHIIED QNYKGRDKAI RQCSLSV--- -------HAG MRGETM---- ---RVNI--- ---------- RQCSLSV--- -------HAG MRGDTM---- ---RFHIIDD HNYKGRDRAI RQCSLSV--- -------HAG MRGEAM---- ---RFHLIEE QNHKGRDKAI RQCSLAVRTS LEQKLRVHSH RSRARG---- ---RAAEEGV RQGKGRDKTI NPSVLSSEED VEGNQKATIA LGTTAN---- -----INQEG EISNETDKVF KDCTIHSHID WDLKDKLSVD KLKAVD---- -----ASTSE DVSSDGDKIF KDCQLVAKLL REKEQGADVG SQGPIQ---- -----GEEDV SVVDDQTRVI GDTKMESELQ VEGDADIETT GIPMAS---- -----GKVEG SVKDSHQRSF KDTNIQSDIQ VEGDAVASTD IISKAS---- -----VNISG SIKDTHHHSF GDTDLASDSR EEGDASVST- GKPKFS---- -----ISLSG SVELEHHRSY GDSELDSDSS GQGDASLNA- GKPTFS---- -----INLSG SVQVAHHRSF RDADVDSDAD QEGDANVTG- GKSEFS---- -----INLSG SVQAKHHRSF QEVTLERAGK AEACFSLPFF APLGLQG--- ---------- SINHK--EAV QEVTLERAGK AEACFSLPFF APLGLQG--- ---------- SINHK--EAV QEVTLERAGR AEGCFSLPFF ASLGLQG--- ---------- SVNHK--EAV QEVTLQRAGK AEGCFSLPFF APLGLQG--- ---------- SINHK--EAV QEVTLERAGK AEGCFSLPFF APLGLQG--- ---------- SINHK--EAI QEVTLERAGK AEGCFSLPFF APLGLQG--- ---------- SINHK--EAI QEVTLERAGK AEGCFSLPFF APLGLQG--- ---------- SVNHK--EAV QEVTLKRASN AISKFSLN-L PSLGLQG--- ---------- SVNHK--EAV QEVTVEQTGN ANAIFSLPSL ALLGLQG--- ---------- SLNNN--KAV KEVEVTRTHK REGSGRFSLP GATCLQGE-- -------GQG HLSQK--KTV KEVEVTRTHK REGSGRFSLP GAMCLQGE-- -------GQG HLSQK--KTV KEVEVTRTHK QEGSGQFALP GAFCLQGK-- -------GEG HLSQK--KTV QEVEVTRTQK QEGSGQFALP GAMGLQGR-- -------GEG HLSQN--KMV KEVEVTRTHK QEGSGQFALP GAVSLQGQ-- -------GQG HLSRK--KTV KEVKVTQTRK QEGSGQFTLL GAISLQGQ-- -------GQG HRSRK--KTV EEVQITEVHS QEGSGQFTLP GALCLKGE-- -------GKG HQSRK--KMV NNTVLYDSSS VNILGKIAL- WITYGKGQ-- -------GQG ESLRVKKKAL NNTVLYDSSS VNILGKIAL- WITYGKGQ-- -------GQG ESLRVKKKAL NETVLQDSSS VNATGTFSIP WSFYAKST-- -------AEG SGLKERKRTM ---------- ---------- ---------- ---------- ---------- NGTVLQDKSS ITALGKFLLP WTTYVQSK-- -------VEG G--RVRDTTL KDTMLTGLSS VNLLVKGFFK QLFKVRG--- -------KAG RSEK---YSI KDTMLTGLSS VNLSVKGFFK QLFKVRG--- -------KAG RSEK---YSI KDTMLTGLSS VNLLVKGFFK QLFKVRG--- -------KAG RSEK---YSI KDTVLEGTSN SKFAIKGIIN QLVKVGGS-- -------GQW QTEKT--DSI KEETLKSDRQ YKFWSQISQG HLSYKHKG-- -------Q-- -------REV KEETLKSDRQ YKFWSQISQG HLSYKHKG-- -------Q-- -------REV RKETLKSEWL CTLWSRVNA- --SCNTK--- ---------- ---------- RTETLKYETQ FGFQILLKMF GFQCKHKH-- -------Q-- -------KEV KTVILKSEKQ YIFWDPMKCF GLRYEHKH-- -------Q-- -------TEV KTETLESEQG CVIQLLVDCL GFRYRRKR-- -------Q-- -------KAV EEARYEESTE AEAKFMAQLY AKFSAK---- ---------- -GTTGSKQSI EEARYEESTE AEAKFMAQLY AKFSAK---- ---------- -GTTGSKQSI EETVYKESTK ADGGFKAKFY ATLCAKQ--- ---------- -GTREDKQTI EEAHFEESSE MEGSIFYEAY VKMGLK---- ---------- -GSSKSKKAI EETTFFKSNT TEGSILNEIY VHFSLK---- ---------- -GTRGSKRAI DNGKITSDVD LEGDGEFDSK PLSVDLEG-- ---------- DVKEDKSKSM ATATLTGQIK ESGSESGSCM GSTETG---- ---------- EVSKSKVKKL ADSTLSGSAD LNVTTDDSVS NKSVVVVD-- -----VHTKD SIEKKTTHSY AESKITTELQ TSGSADGKFT AGTARSIN-- -------VET SLSGDRKRTL SDMKIAKQST LSEDGKIKTD VKKEIVD--- -----VDVEE KGSKKNSETV EIPVHTPVAF ALT------- ---ELEIRHD GRFELCLMSD TKGGFEVDGL EIPVQTTIAF AVT------- ---ELEIRHD GHFELCLMSD VKGGFEVDGP EIPTNTPIAY SLI------- ---ELKIKHD GQFELCVLSD TNGGFDKVDS ELPPHTTIAY GLS------- ---ELEVKPN GHYELCLMSG THGGFEVDGS EIPISTTLAY GVS------- ---ELVIHQD GRFDLCVTSD TDGGYETDSV DIPPKTTLAY SVI------- ---ELDIAHT GHYELCLLPA VKGGFEIDGP EIPPGTVIAY SIR------- ---ELNIRKN GEYDIGLQPG TTGGIES--D EIPPGTVIAY SVL------- ---ELEIREN GEYGICLQPG AIGGFD---- EIPSGTVIAY SVL------- ---ELQVQKN GHYDICLQPG RIGGFADNPD DIPPDTVLAY SVM------- ---EISIDAE GCFELCLFPR GLGTDETSEI EIPAATTIAY GVI------- ---ELYVKLD GQFEFCLLRG KQGGFE-NKK EIPAATTIAY GVI------- ---ELYVKLD GQFEFCLLRG KQGGFE-NKK EIPAPTTIAY GVI------- ---ELYVRAD GQFEFCLLQG KHGGFE-QER EIPAPTTIAY GVI------- ---ELYVRAD GQFEFCLLQG KHGGFE-HER EIPAPTALAY GVI------- ---ELYVKLD GQFEFCLLQG KHGGFE-LER EIPAPTTLAY GVI------- ---ELYLRVD GQFEFCLLQE KHGGFQ-QTR EIPAATTIAY GIM------- ---ELFVKQD GQFEFCLLQG KHGGFE-HER EIPPATTIAY GVI------- ---ELFIKCD GQFEFCLLDE QQGGFE-RES EIPPATTIAY GVI------- ---ELFIKCD GQFEFCLLDE QQGGFE-REN EIPPATTIAY GVI------- ---ELFIKQN GQFEFCLLDE QQGGFE-KES EIPAPTTIAY GVI------- ---ELHIRRD GQFEFCLLHE QEGGFE-REN EIPAPTAIAY GVI------- ---ELYIKRD GQFEFCLLHE QQGGFE-KES EIPPQTAIAY GVI------- ---ELLIKCS GQYEFCLVPE KKGGFE-KEK EIPPPTAIAY GVV------- ---ELYIKHN GTFDFCLLSE KKGGFE-KEN EIPPQTVIAY SVK------- ---ELHLKTN GQFELCLLSD KCGGFDKAEW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---DICVAPE SQGGFEREQ- VIPAHTTIAF SVL------- ---ELYVRLD GRLDICVAPE SMGGFEKEQ- VIPAHTTIAF SIC------- ---ELFVRLD GRLDICVAPE SQGGFEREQ- VIPAHTTIAF SVC------- ---ELFVCLD GRLDICVAPE SQGGFEREQE VIPAHTTIAF SVC------- ---ELFICLD GRLDICVAPE SQGGFEREQ- VIPAHTTIAF SLF------- ---EVYVHLD GHFELCVTSE SKGGFEKEQ- VIPAHTTIAF SVF------- ---ELYIRLD GHFDLCVTSE SEGGFEKEQ- VFPAHTTIAF SVF------- ---ELFIYLD GAFDLCVTSV SKGGFEREE- VFPAHTTIAF SVF------- ---ELFIYLD GAFDLCVTSV SKGGFEREE- VFPAHTTIAF SVF------- ---ELFIYLD GAFDLCVTSV SKGGFEREE- VFPAHTTIAF SVF------- ---ELFIYLD GAFDLCVTSV SKGGFEREE- VFPAHTTIAF SVF------- ---ELFIYLD GAFDLCVTSV SKGGFEREE- VFPAHTTIAF SVF------- ---ELFIYLD GAFDICVTSV SKGGFEREE- VFPAHTTIAY SVF------- ---ELFIYLD GAFDLCVTSV SKGGFEMEE- VFPAHTTIAF SVF------- ---ELYIRLD GNFELCVTPI AKGGFEKEK- VFPAHTTIAF SVF------- ---ELYIRLD GNFELCVTPI AKGGFEKEK- VFPAHTTIAF SVF------- ---ELYIHLD GNFELCVTPI AKGGFEREK- ---------- ---------- ---------- ---------- ---------- VFPAHTTIAF SVF------- ---ELYIQLD GNFELCVAPE SRGGFEKEP- VFPAHTTIAF SVF------- ---DLYIHLD GHFELCVSTA SKGGFEKEP- VIPAHTTVAF SVF------- ---ELYIRLD GSFELCVAAE LPGGFEREE- DLPPETPLAY NVC------- ---EILVKED GGIDLMYTRD GSGGFTAKPG SLPANTPLAY NVT------- ---ELRVSST GKLELMVEEG TKGGFDTVDS RIPADKPVSY HVC------- ---ELHITTE GGIRLLILGE GTGGFDKPDE IIPKGTVLGY GCYRLRIVDK DQGSVEMDID KELEDKDVTD AVDGAP---- DIPNGTVMAY GCYGLKLLEG -LGLIELDVD KKLKD-VVTD ATDGKP---- ELPSNTILGY ACY------- ---EAQFDLD TGTFELVLPD ATDGGG-EVG ELPNNTILGY ACN------- ---EITFDSA MGTFQLVLAD ATDGGG-MST ELPNHTILGF ACY------- ---EITIDPD LGTFQLLLPD SIDGGDPQEF TIPKGCVLAF RVR------- ---QLMVKGK DEWDIPHICN D---NMQTFP TIPKGCVLAF RVR------- ---QLMVKGK DEWDIPHICN D---NMQTFP TIPKGCVLAF RVR------- ---QLMVKGK DEWDIPHIYN D---NMHTFP TIPKGCILAF RVR------- ---QLVVKGR DEWDIPHICN D---NMQTFP TIPKGCILAF RVR------- ---QLMVKGK DEWDIPHIYN D---NMQTFT TIPKGCILAF RVR------- ---QLMVKGK DEWDIPHIYN D---NMQTFT TIPKGCVLAY RVR------- ---QLMVNGK DEWGIPHICN D---SMQTFP TIPKGCVLAY RVR------- ---QLIIYGK DEWGIPYICT D---NMPTFN TIPKGCVLAY RVR------- ---LLRVFLF NLWDIPYICN D---SMQTFP TIPSGSTLAF RVA------- ---QLVID-- SDLDVLLFPD K---KQRTFQ TIPSGSILAF RVA------- ---QLVID-- SDLDVLLFPD K---KQRTFQ TIPSGSTLAF RAA------- ---QLVIG-- SDWDILLFPD K---KQRTFL TIPAGSILAF RVA------- ---QLVIG-- SDWDILFFPD K---KQTTFR TIPSGSVIAF RVA------- ---QLVIG-- SDWDILLFPD K---KQRTFR TIPSGSILAF QVA------- ---QLLID-- SDWDILLFRD KKHKKQRTFG TIPAGSILAF RVA------- ---QLLIG-- SKWDILLVSD E---KQRTFE TLQKGMVMAY KRK------- ---QLVIKEK ---AILISDD DEQRTFQDEY TLQKGMVMAY KRK------- ---QLVIKEK ---AILISDD DEQRTFQDGY TVPQGTVMAY KKK------- ---QLVFRED GRAILLISDD DKQKTFPEIK ---------- ---------- ---------- ---------- ---------- MLPSGTVMAY KKK------- ---QLVFQEP GWDILLIPDE RQETFPDEFQ PIPKGSVLAY KKQ------- ---QLVIENN TCVILPSA-T KKKMTFPGTP PIPKGSVLAY KKQ------- ---QLVIENN TCVILPSA-T KKKMTFPGTP PIPKGSVLAY KKQ------- ---QLVIENN TCVILPSA-T KKKMTFPDRP PIQKGSVLAY KKQ------- ---QLVIEDN TCVILTSANT KKKMTFP--- TIPPNRVLSY RVK------- ---QLVFPNK ETMR------ ---------- TIPPNRVLSY RVK------- ---QLVFPNK ETMNIHFRGK TKSFPE---- ---------- ---------- -----AFPEG ---------- ---------- TITPEKVLAY RVK------- ---QLVFPSA ERMDICFLDK TRSFPE---- SITPQKVLGY RVK------- ---QLVFPNA ESMEK---DG GSSCT----- TVPPGTVLGY RLK------- ---QLVFPNE ESMNIIS-EK TKSFPHEKDG TIPRGCTLAF RAM------- ---QLTIGDA MWGKRHRKQE YL--VTFWFA TIPRGCTLAF RAM------- ---QLSIGDA AWGVNHFPEN NQ--PTFASD VIPKGCTLAF RTI------- ---PLHIRDG AWDLDYFPVE ALRRAAYIAD HIPKSCILAF RAK------- ---KLQVAKK SRYDDRIPNN TV-HSIFRVA IIPKDCVLAY RIL------- ---PLIIADE SWDLSYHPG- ---GKTFVAD VIPKNTSIAF SMV------- --ELLVSVKD GSIQVILSHD ENGGFTTENF EVPAGTALAY TVR------- --ELLVSTVD GQFRVVLDTS CHGGFVFSLD TLPSNTVLAF SCN------- ---TFSVTEY GGIDFHAAPD EADFSTKTLL EIPSNTPLAF RML------- ---EILVRPD RSIQLMQLPN SEGGFEIIKD DIVGKTNLAY NIV------- ---ELKIHPD GTIGVCMTEN DKGGFDVVDL HQTKAVG--V TGAPAN---- ---------- ---------- ---------- PRTTAAG--V TGAPAN---- ---------- ---------- ---------- PAIKKDQPCF SGAPAHS-SD ---------- ---------- ---------- SEEQLVG--- ---------- ---------- ---------- ---------- VGSESLD--- ---------- ---------- ---------- ---------- VKVKQAVT-V SAAPGNP--- ---------- ---------- ---------- SLELPSWEAL TTVDGG---- ---------- ---------- ---------- ---LPSWESP DAVDGR---- ---------- ---------- ---------- PISRSLHHST DTVDSL---- ---------- ---------- ---------- PSPVPSEVDG QFPLMQEGFP ---------- ---------- ---------- RIDSVYLDPL VFREFAFIDM PDAA------ ---------- ---------- RIDSVYLDPL VFREFAFIDM PDAA------ ---------- ---------- RSNSVLLDPL PFREFVFWDM PDAG------ ---------- ---------- RSDSAFLDLL PLREFAFWDT PDAG------ ---------- ---------- -SGSVFMDPL PFQEFASGDM PDAG------ ---------- ---------- ESSCASLEPL PLLELGFWDM TDAL------ ---------- ---------- KLDSVYLDPL AYREFAFLDM LDGG------ ---------- ---------- SEGSTSPHSV LFRDTSFLYH PDAVD----- ---------- ---------- AEGSTSPHSV LFRDTSFLFH PDAVD----- ---------- ---------- TEGSAYPHSV QFRDAAFLYQ PDAVD----- ---------- ---------- TEGSSYPYSL PFRDSSFLYQ PDAVD----- ---------- ---------- AEERSFP-SV AFRDSLFPHI LDAVD----- ---------- ---------- -PPRAFDTLS CVSSQCYGDS VDFG------ ---------- ---------- LEKHQHSNPL PSDQLVLFDC TMVI------ ---------- ---------- DKGKEAYVST ACSALDCVDA STQKH----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SGVVQADA-- ---------- ---------- ---------- ---------- S--AYEDM-- ---------- ---------- ---------- ---------- EKFVDIDV-- ---------- ---------- ---------- ---------- TAAHPFDQ-- ---------- ---------- ---------- ---------- PDAFSMDQ-- ---------- ---------- ---------- ---------- MNYCLFDE-- ---------- ---------- ---------- ---------- RECCVFDE-- ---------- ---------- ---------- ---------- KKHCVFDE-- ---------- ---------- ---------- ---------- PGEKSGEEKV ILIQASDV-- ---------- ---------- ---------- PGEKSGEEKV ILIQASDV-- ---------- ---------- ---------- PGEKPEDEKF TLIQASDV-- ---------- ---------- ---------- PG-------- -VIQASDV-- ---------- ---------- ---------- PGE------- ---------- ---------- ---------- ---------- PGEKP----- ---EEKFT-- ---------- ---------- ---------- PGEKPGEGKF ILIQASDV-- ---------- ---------- ---------- PLCVLQRQG- -STVQMIS-- ---------- ---------- ---------- KIRRVPCSAF ISPTQMISE- ---------- ------EPEE ---------- PPATGHKRST SEGAWP---- QLPSGLSMMR CLHNFLTDG- ---------- PPPTGHKRST SEGAWP---- QLPSGLSMMR CLHNFLTDG- ---------- SLQAGRRPSS SADSHPHPCF SLAS-IRALS DYFHFQPDGS ---------- PQQEGGQLQR SS-------- CLTS-TKFLS LRFKFLSDGP ---------- PLREGHSASH GADGQPPQFS RLVSGMSFPS EHLKFQSDGP ---------- LPKKGHQLTR GAGS------ -----QSLLS GCFKIQSDGF ---------- P-SSGDRKAV GQRHHG---L NVLAALCSIG KQLSLLSDGI ---------- EISEMVGYCA ARSEGLLPSF HTISPTLFNA SSNDMKLKPE LFLTQQFLSG EISAMVGYCA ARSEGLLPSF HTISPTLFNA SSNDMKLKPE LFLTQQFLSG LQGLPLSPEI LSISDDNKRK AFFVGKVQRQ SAMGTKRRP- ---------- ---------- ---------- ---------- ----TMRGP- ---------- ERTLVLS--- ---------- ---------- ---DTRRGP- ---------- KYASASEPTE IYRTEL---- ---------- --QGLWIND- ---------- KYASASEPTE IYRTEL---- ---------- --QGLWIND- ---------- LKLYDLPVTL RYQEEVI--- ---------- -ETGSWIDD- ---------- MRFVGMSGHL RYQDLVI--- ---------- -ETGSWIND- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GASCL----- ---------- ---------- ---------- ---------- GFAPREVDA- ---------- ---------- ---------- ---------- GFAHTEVEA- ---------- ---------- ---------- ---------- GPSQGKLGV- ---------- ---------- ---------- ---------- PIAKKMKESR LRWFGHVQ-- ---------- ---------- ---------- GATEEYDYS- ---------- ---------- ---------- ---------- DVTDGPVHPE CP-------- ---------- ---------- ---------- ADVDDVDG-- ---------- ---------- ---------- ---------- QKTKKDSFDF VKSMLFS--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CSKGAEKT-- ---------- ---------- ---------- ---------- ---------- ---------- ----DQLRQE LEALGQHFHL LAA------- ---------- ---------- ----THLRQE MAMLSKHFHL LSA------- ---------- ---------- ---STCLQQE LDQLSNHFQL LSA------- ---------- ---------- ---AFYCSAE LDKLGSHFQL LSG------- ---------- ---------- ------LQKE LDSLEDHFHL LTA------- ---------- ---------- ---THNMQKE LVGLEGQFKV LSK------- ---------- ---------- ---CQEEMLP FAMLLNGLFP FS-------- ---------- ---------- ---CLEELLP FDAH-NGLFL FICLLPVFAL ---------- ---------- ---CNWNN-P KEKLSEKLYI MLY------- ---------- ---------- ---LHTQKKA LADVQTCFCA LAD------- ---------- ---------- -HGISSQDGP LSVLKQATLL LERNFHP--- ---------- ---------- -HGISSQDGP LSVLKQATLL LERNFHP--- ---------- ---------- -QGLPAQDKP LSVLKQATLL LERNFHP--- ---------- ---------- -QGLPASDGP LSVLKQAPLF LERNFHP--- ---------- ---------- -QGPSALDWP LSVLKQATLL LERNFHP--- ---------- ---------- -QGASVVDEP LGVLKQVTWL LKRNVHP--- ---------- ---------- -QGISSQDGP LRVVKQATLH LERSFHP--- ---------- ----NGMYFG SENPIPSHAS LSVLKEGLSQ FKAQFQP--- ---------- ----NGMYSG AENPVPSHAS LSVLKKDLSQ LKAQFQP--- ---------- ----NEMYSG AKNLIPSDAS ISILKQDLSR LKTQFQP--- ---------- ----NERRSG DRSIIPSNAS LSVLKQDLLL LKVQFQP--- ---------- ----NEKQPD PESLIPSDAS LSILTKDVLH IKTQFQP--- ---------- ---------- RHCVDVKTIP SEVSLSALNL FFQNFDL--- ---------- ---------- -YPLKKKDTY VSILPKGIAA HEKHFSA--- ---------- ----GSRHHT DEKNVCSETS LSALKQDIEE AKQQLQP--- ---------- ---------- ------MREQ LGGFLGRFSM GR-------- ---------- ---------- ------IREQ LGGFIGRFSV GR-------- ---------- ---------- ------IREQ LGGFIGRFSV GR-------- ---------- ---------- ------IREQ LGGFIGRFSM GR-------- ---------- ---------- -----SSTET LSEAVRHQSG SF-------- ---------- ---------- ------IREQ LGGFIGHLS- -M-------- ---------- ---------- ------ITNS L-------LF QR-------- ---------- ---------- ------ITEQ LGGLMGRFSV WR-------- ---------- ---------- ---------- ----TATFAL ---------- ---------- ---------- ---------- ----TATFAL ---------- ---------- ---------- ---------- ----TATFAL ---------- ---------- ---------- ---------- ----TATFAF ---------- ---------- ---------- ---------- ----TPTFAL ---------- ---------- ---------- ---------- ----TTTFAM ---------- ---------- ---------- ---------- ----TATFAL ---------- ---------- ---------- ---------- ----SGSSSM ---------- ---------- ---------- ---------- ----SGSSSM NK-------- ---------- ---------- ---------- ----SGSSSL TK-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----SRSFSF IR-------- ---------- ---------- ---------- ----TRSFSL NT-------- ---------- ---------- -----TLGER LRRLVARLAV WRGSSSP--- ---------- ---------- -----PPNTE LAHTMKPLLS LPEQQRN--- ---------- ---------- -----GIDKE AEHQLQGICG MSDESRK--- ---------- ---------- -----GEDEP DNPFID---- -RTESTN--- ---------- ---------- -----PDGQN DSALKSEFKT LLESPSFG-- ---------- ---------- -----PDGP- DTALTSAFNA LMKSPHKG-- ---------- ---------- -----PDGQK DKALKAVFDD LLKSPLLG-- ---------- ---------- -----PDGQN DKALKAVFDD LLNSPLCS-- ---------- ---------- -----PDGQN A--------- ---------- ---------- -------GDV HEGFRTLKEE VQRETQQVEK LSRVGQSS-- ---------- -------GDV HEGFRTLKEE VQRETQQVEK LSRVGQSS-- ---------- -------GAV HEDFRTLKEE VQRETQEVEK LSPEGKSS-- ---------- -------GEV HEDFRTLKEE VERETQEVEK LSPRGRSS-- ---------- --------EE HEDFKTLKEE VQREIQEVKK LSRVGQSS-- ---------- -------KEE HEDFKTLKEE VQREIQEVKK LSRVGQSS-- ---------- -------GEM HEDFKTLKEE VQRETQEVEK LSPVGRSS-- ---------- -------GEM HEDFKTLKKE VQQETQEVEK LSPVGRSS-- ---------- ---EKLIGEM HEDFKTLKEE VQRETQEVEK LSPVGRSS-- ---------- ---VPAEGAF TEDFQGLRAE VETISKELEL LDRELCQL-- ---------- ---VPAEGAF TEDFQGLRAE VETISKELEL LDRELCQL-- ---------- ---TEHWLAT TDDYQGLRAE VKAWAMGLEG LSKGLCGQ-- ---------- ---MEDRLAT TEGFQGLQAE VEAWAVGLEG LSREPCRQ-- ---------- ---AEDQLVT TEDFQGLQAE VDAWAAGLEA LSREPCRQ-- ---------- ---AEDWSAV TGDFRGLQAE VGAQAQVLQG LSKELCER-- ---------- ---DEEELIE AADFQGLYAE VKACSSELES LEMELRQQ-- HLPKYEQVHI LPVGRIEEPF WQNFKHLQEE VFQKIKTLAQ LSKDVQDV-- HLPK-EQVHI LPVGRIEEPF WQNFKHLQEE VFQKIKTLAQ LSKDVQDV-- ---------I LPIGRIQEPI SRDFKSLQNE VSREIEAVAE LPRDIRDA-- ---------I LPMGRIREPT GQDFKHLQKE VCRETEATAQ LPKDTQDA-- ---------I LPVGRIDLPK SQDFQYLQEE ISWETEALAQ LSKDSQND-- ---------I EPIGRIQEPA HLDFKCLQYE VSEQTRLLPE LSKDVQEV-- ---------I VPIGRIQEPA HLDFMCLQNE VYKQTEQLAE LSKGVQEV-- ---------I DPIGTIEEPA NLNFMCLQHE VSEQTQLLAE LSKDVQEV-- ---------I DPIGTIKEPT HLDFMCLQNE VSEQTRLLAE LSKDVQEV-- ---------- ------KSLG SEDSRNMKEK LEDMESVLKD LTEEKRKD-- ---------- -----GKSLG SEDSRNMKEK LEDMEGVLKD LTEEKRKD-- ---------- ------KSLS LEDFRNMKKK EQDMVRGLXD LTEKEQKD-- ---------- -----GKSLN LQNFRSIKET VQDMVRVLQD LTPEEQKE-- ---------- -----GKSLS LEDFPSVKER MQDMVRVLQN PT-EERKE-- ---------- -----GKSLS LEGSRSMKEK VQDLVRVLQD LTEKEQKW-- ---------- ---------- ------VEKE AKEKCHILSQ LADELNAI-- ---------- ---------- ------LEEE VKERCGILCQ LTDELNAV-- ---------- ---------- ------VASE VKYSCRNFPD LSPDVLLI-- ---------Q SDEGSVAKTA LNIKENMWME VQVECEQFSF LSAKLRGL-- ---------- YDGG------ ---IDDLKTE VENKCAELSQ LSTDLRAK-- ---------- ---------- -EEILKVFKE NGKCKEVLRS VQHLLQTP-- ---------- ---------- -----PSSDS LVKASFLHGI LSSEIPKD-- ---------- ---------- ----FVKSSK FSSIQQFFKS IIGSVEQS-- ---------- ---------- -----DKEPT PSRPVPDMEE IRQQLKP--- ---------- ---------- ---LFYPPEE VAAGKNKTEL TDSLVDCIR- ---------- ---------- ---LPVGTRS SLLQQLTKVL EDRRALSSLQ ---------- ---------- ---LPLSTRS SLLQQLSEVL GEPGAVSSLH ---------- ---------- ---LPASTRS ALLQQITKLL QDQITISALQ ---------- ---------- ---LKASTRS SLFQYVCSVL KERGAVSLLE ---------- ---------- ---LPASRKS FLLQEISELM QSPLAISTLQ ---------- ---------- ---LPSSTRF SLFQQISLLL QNSAVISILG ---------- ---------- ---PPRLMTH FLINRLRDIM IDRSALACLQ LGTRIKENNQ LMIEATGLHA LAQLPKSTRC ALFKGLQDIM IDRSALACRQ ---------- ---------- ---LPQSTRY PLINQLQETL TDRAALSYLQ ---------- ---------- ---LSVELRF SILVLLRKIM LDRTILSALV ---------- ---------- FAELPEPQQT ALSDIFQAVL FDDELLMVLE ---------- ---------- FVELPEPQQT ALSDIFQAVL FDDELLMVLE ---------- ---------- FMELPEQQQI ALNDVLQAVL LDEELLVVLE ---------- ---------- FVELPEQQQR ALNDVLQAVL FDEELLLVLE ---------- ---------- FAGLLEQQQT ALNNVFQAVL SDEESLMALE ---------- ---------- FAELPEPQQT ALNDVLQEVL FDEEMLVVLE ---------- ---------- FAVLPAQQQR ALFCVLQKIL FDEELLRALE ---------- ---------- FVKLPEDKQR ALYKSLCELL LHEETLTALE ---------- ---------- FVKLPEDKQR ALYKSLCELL LHEETLTALE ---------- ---------- FVKLPEDKQR ALYKTLCELL LREEMVTALG ---------- ---------- FVMLPEDKQG TLYKIFCELL HREEMVTALK ---------- ---------- FVKLSEENQE ALYRILCELL LREEVVTQLE ---------- ---------- IVNLISKRGS SLGKFFFFFL CDEKLSIYIK ---------- ---------- WKQLPDVQCL ELYTLLCQIL YDGQALSKLH ---------- ---------- FEALSEGKCQ QLFRLYSELL YQGEAICLLE ---------- ---------- ---------- --LRRFLSGI VYGNPFRADD ---------- ---------- ---------- --LRRFLSGI IYGNPFRADD ---------- ---------- ---------- --LRRFLSGI IYGNPFRADD ---------- ---------- ---------- --LH------ ---------D ---------- ---------- ---------- --LKR----- ---------S ---------- ---------- ---------- --GRQ----- ---------S ---------- ---------- ---------- --MRKIL--- -----YNLDD ---------- ---------- ---------- --LRRCLSEF FYGSPFRSDG ---------- ---------- ---------- --LYRLR--- --NILFERNR ---------- ---------- ---------- --LYRLR--- --NILFERNR ---------- ---------- ---------- --LYRLR--- --NILFERNR ---------- ---------- ---------- --LYRLR--- --NILFERNR ---------- ---------- ---------- --LYRLR--- --NILFERNR ---------- ---------- ---------- --FYRLR--- --NILFERNR ---------- ---------- ---------- --LYRLR--- --NILFERNR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --LRRLK--- --HNLFHRNK ---------- ---------- ---------- --LRRLK--- --NNLFHRNK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --LR------ --NTLFHRNK ---------- ---------- ---------- --LR------ --NNLYRSGK ---------- ---------- ---------- --SRSLRAAP EGRTSPSDMK ---------- ---------- ---------- SVTSAVLKVM EAPADLPVVE ---------- ---------- ---------- TFVGAVLDIC DTPVTIDPLL ---------- ---------- ---------- PFDDP----- ---------- ---------- ---------- ---------- KIIECFRNIL ASPGHIKPLR ---------- ---------- ---------- DIIKCFREIL ATPEYCHVIE ---------- ---------- ---------- KIIGLYKEIL SYPQAVAPLR ---------- ---------- ---------- KIFDLYRKIL SCPAAVAPLR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------L LSSLSK--LL GKKKELQDLE ---------- ---------- ---------L LSSLSK--LL GKKKELQDLE ---------- ---------- ---------L LSSLSK--LL GKKKELQDLE ---------- ---------- ---------L LCSLSK--LL GKKKELQDLE ---------- ---------- ---------L LTSLSK--LL GKKKELQDLE ---------- ---------- ---------L LTSLSK--LL GKKKELQDLE ---------- ---------- ---------L LTSLSH--LL GKKKELQDLE ---------- ---------- ---------L LTSLSH--LL GKKKELQDLE ---------- ---------- ---------L LTSLSH--LL GKKKELQDLE ---------- ---------- ---------L LEGLEG--VL RDQLALRALE ---------- ---------- ---------L LEGLEG--VL QDQLALRALE ---------- ---------- ---------L LGGLGQ--VL RDEPALQALE ---------- ---------- ---------L LGALGQ--VL RDEAALQALD ---------- ---------- ---------L LGGLGQ--VL QDEPALQALE ---------- ---------- ---------L LAGLVQ--VL REEPALQTLE ---------- ---------- ---------I LVNIGK--IL QDQPSMEALE ---------- ---------- ---------M FYSILA--ML RDRGALQDLM ---------- ---------- ---------M FYSILA--ML RDRGALQDLM ---------- ---------- ---------L FHTILA--KL KDQGALQDLT ---------- ---------- ---------I LHNILA--RL KDREALQDLM ---------- ---------- ---------V FHTILKNLKL KDRGTLQDLM ---------- ---------- ---------V LSSFLSMLYE GDRNVLHDLM ---------- ---------- ---------V LSSILSMLYE GDRKVLYDLM ---------- ---------- ---------V FSSFLHMLS- -DRDVLYDLM ---------- ---------- ---------V FSSFLHMLC- -DRDVLYDLM ---------- ---------- ---------V LNSLAK--CL GKEDIRQDLE ---------- ---------- ---------M LNSLAK--CL SKEEIRQDLE ---------- ---------- ---------V LSCLRG--QL P-------LS ---------- ---------- ---------A LNCFTK--CL SSEEELQDLE ---------- ---------- ---------V LSCFTK--CL SKDEELQDLE ---------- ---------- ---------V LSCLTK--CL TEDEQLRDLQ ---------- ---------- ---------I VKSIKA--VM RDRNLLEELT ---------- ---------- ---------V VKTIKA--VM RDRNLLEELS ---------- ---------- ---------V FNTIKA--VM RDKNLLQELT ---------- ---------- ---------F LSGFVA--VM RNKDLLQKLA ---------- ---------- ---------F LKSIIA--VI IDSDLLQELK ---------- ---------- ---------- ---KSIRSLM ELEVELSHDL ---------- ---------- ---------- DLRASLLEIL KVPKAIGPLD ---------- ---------- ---------- -SLEAIYLLL LAVEGSSENN ---------- ---------- ---------- MLLLPEQSLN DARRSLKELL ---------- ---------- ---------- --YSALFEWL VHWLHVIHSH SVLDQVCLD- --ESTSLRDL PAS-ESHEQT VHSILELLE- ---------- RALDQACPD- --ERASLGHV TAA-ESQEQ- -NSILELLE- ---------- DVLEQMCMD- --KGSALGDF KTT-ACQKQN VQAILDLLE- ---------- SVLNQIRHG- --ERPPL-DS GQA-DSQTQT VQALLEVLV- ---------- NALDQMHVD- --QKPDLSES GLA-ESHQKN IKAVLDLLG- ---------- STLEDLCGG- --TQPDPSTL AEV-PELKVT LELIQKSAG- ---------- SVLEGLCCS- --DSPDMTEN DELSEGERGA LSAILGQLGL V--------- SVLEDLCCG- --ESLDLTQH D---EGERTF VSAILKQLGL A--------- AVLEELCDG- --DTVESIEE S----SEIQR KSTFLDQQDP V--------- DTLETLSSD- --EAPCFLTK ELS-EKQSQI IREFLHLLKW ESHENNQYPT PVCDDLVSG- LSPTVAVLG- -ELKPRQQQD LVAFLQLVGC S--------- PVCDDLVSG- LSPTVAVLG- -ELKPRQQQD LVAFLQLVGC S--------- QVCDDIVSS- LSPSLVALG- -ELKPSQKHN LTTFLRLVGC S--------- QVCEDIVSS- LSPSLAVLG- -KLKPSQQRD LVAFLRLVGY S--------- QVCEDVVSG- LSPPLAILG- -ELKPLQQQD VMAFLCLVGY G--------- QVCDSVASSR LLPPLAGLG- -ELKPSQQQQ LMAFLQLAGC S--------- QVCDDVAGG- LWSSQAVLAM EELTDSQQQD LTAFLQLVGY R--------- DVLDALCAG- --DKP---DL KELKPAQQQD LADFLQLVGC S--------- DVLDALCTG- --DKP---DL KELKPAQQQD LADFLQLVGC R--------- DMFDDICTG- --GKP---DL EELKLEQQRD LLDFLQLLGC S--------- EVLDSICTG- --DKPDFTEL KELKPAEQQH VTDFLQLVGY S--------- DVLDNICST- --DNPELKVM PDLKPPEEPT IEEFLQLLGI G--------- HRLDQLVLA- --EKPDLSGL HQLKPSERKN VTNFLQLLGY T--------- AVVEDLCSK- --RKPTQAAF DELMPSQRII AENILYLSGY D--------- TILNELSLG- --EQPNLSGL HELEPTQVQN VKELLQFLGY S--------- RAFEGLTYP- ---------- ---------- ---------- ---------- RTFEELTHS- ---------- ---------- ---------- ---------- RTFEELTHS- ---------- ---------- ---------- ---------- RTFEELTHS- ---------- ---------- ---------- ---------- QTFEELTHS- ---------- ---------- ---------- ---------- RTFDELTHS- ---------- ---------- ---------- ---------- RTPDNVTNS- ---------- ---------- ---------- ---------- KLADISTNS- ---------- ---------- ---------- ---------- RVMDVISRS- ---------- ---------- ---------- ---------- RVMDVISHS- ---------- ---------- ---------- ---------- RVMDAISRS- ---------- ---------- ---------- ---------- RVMDAISRS- ---------- ---------- ---------- ---------- RVMDAISRS- ---------- ---------- ---------- ---------- RVMDAISRS- ---------- ---------- ---------- ---------- RVMDAISRS- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RIVSIIPSS- ---------- ---------- ---------- ---------- GVVEIVANS- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RVMDIIAHP- ---------- ---------- ---------- ---------- RTMDVIATT- ---------- ---------- ---------- ---------- GGYRPSSRR- ---------- ---------- ---------- ---------- ELLDDVVDGR -----KPKPF AEFKSKCTNP AA-VLGFLST IDFQM----- VLIKQAHKAA SANTEKVITV DKLRNTVGQS DA-VVSLLKQ IGFTFRD--- ---------- -----EPNHY EPFKSIVS-- ---------- ---------- DLLEDSVLSL DGEKVNALKE DAFLDSMGPC QG-WRELLDI IGFQFKE--- QLLDNVCDYF DKEKVKSYSL DEVKSLFGSC NS-WERLLTI LGITFDSK-- DMLEKALSAV EKKNFEPLEM KEFQTKAGPG YGPLKDLLPL IGFNIDDS-- DLLEKGLSSA EKKNPKPFEL KELKTKAGAA YENCKELFLL LGFNMDES-- ---------- ---------- ---------- ---------- ---------- LALEGALDKG ---------- -HEVTLEALP -KDVLLSKEA V--------- LALEGALDKG ---------- -HEVTLEALP -KDVLLSKEA V--------- LTLEEALGKG ---------- -HEETLEALP -KNVLLSKGA M--------- LTLEGALDKG ---------- -HEVTLEALP -KDVLPSKEA M--------- LMLEGALDKG ---------- -HEVTLEALP -KDVLVSKEA M--------- LMLEGALDKG ---------- -HEVTLEALP -KDVLVSKEA M--------- QTLEGALDKG ---------- -HEVTLEALP -KDVLLSKDA M--------- QMLEGALDKG ---------- -HEVTLEALP -KDVLLLKDA M--------- QKLEGALDKG ---------- -QKVTLEALP -KDVLLSKDA M--------- EALEQGQSLG -PVEPL--DG PAGAVLECLV LSSGMLVPEL A--------- EALEQGQSLG -PVEPL--DG PAGAVLECLV FSSGMLVPEL A--------- DSLEQGLCSG -PVEPR--DG PVGAILESLV LPSGQLETEL A--------- ESLEHGLRGG -LLESR--DG PVGAVLECLV FSSRRLEKRL A--------- DSLEQGLCGG -LVEPQ--DG PAGAMLECLV LACRRLEREV A--------- DTLEQGLCCG -SVAPL--DG PVDTLLECLV QSSGELETHL A--------- ASLGQGLCSG GQVEPL--DG PAGCILECLV LDSGELVPEL A--------- NMLELDSSGH LD-------G PGGAILKKLQ QDSNHAWFNP K--------- NMLELDSSGH LD-------G PGGAILKKLQ QDSNHAWFNP K--------- DMLDGNLWDH T--------- --GSFLSEMR EDSRNVWLES R--------- DLLDWGPSDH LD-------S FGGTFLSEMQ EDSRNLWLKL R--------- DMLDRDPLGP VD-------S SGGTFLSKMQ EDPRNPWLQS R--------- KMLELSQLGH MD-------G PGGKILDELR KDSSNPCVDL K--------- NMLELNQLGH MD-------G PGGKILDELR KDSSNPCVDL K--------- KMLELNQLGH MD-------G PGGKILDELR KDSSTPHDVL K--------- KMLELNQLGH MD-------G PGGKILDELR KDSSLSWINL K--------- QRVSEVLISG ELHME----D PDKPLLSSLF NAAGVLVEAR A--------- QRVSEVLISR ELHME----D PDKPLLSSLF NAAGVLVEAR A--------- AKVGLVLISP HLEME----G LAGLLISSLF NAAGFLVKAH T--------- QRVSEVQCSG ELQMN----S PANSLISSLF NAAGVLIEAR A--------- RRVSEVRRSG ELQME----G PA--VIFHCI YAAGILIEEH T--------- QRVSEVQCSG ELRME----G PADPLISSLF NTAGILVEAR V--------- EKMEALLDDP DNCELTTQSP DLEVLLSTLK ISARCDLLSL T--------- GKMEAVLDDP DNCELTTQSP DLEVLLSTLK GSPRCDLLSL T--------- QKMEDIPEQN DGYELKTESP HLKDLFSTLQ HSPRDCLLQV A--------- FQLEEALQVS GQCKLKADEP ELQNLVENLQ DCSGVIITEL A--------- FKLEEAFEDA DKCELKSDNP DLEDLLNNLQ DSAGSINLFL V--------- NILQAYTKQN --------LY DEFDMEESHN YHPFLLLADF HFK------- DLFHEAAVFL ETKILKTTLL SILQERIYSL EANLLPFLSL AG-------- FYLNSCHSAL SKTIVENIGL WKPLLLSLNF FIPDDLSLNK AS-------- RTENSILLNS LN-------- ---------- ---------- ---------- EHEKLPWDDK FWSFIGDDGF KAASRFFKLI NVNFKYGEET S--------- ---------- ---------- ---------- -------PSG P--AGQRAPA ---------- ---------- ---------- -------QTA Q--ADQLAPT ---------- ---------- ---------- -------QSS QEEPSRSTSL ---------- ---------- ---------- -------LSG E---EDFSCT ---------- ---------- ---------- -------KCD E-----AVSV ---------- ---------- ---------- -------KKP SG-QHQKQST ---------- ---------- ---------- -------CPV EG-SSSCSLQ ---------- ---------- ---------- -------DPV EGRLSSLPPQ ---------- ---------- ---------- -------FPA ED-LQRETAK STSLSITNGC QKSTANHSHP VMASDQNGGH SAKSNQNGCS KAASKPSMEL ---------- ---------- ---------- --LQGGCPGP EDA-GSKQ-L ---------- ---------- ---------- --LQGGCPGP EDA-GSKQ-L ---------- ---------- ---------- --VQGERLGS QDV-VDNQKL ---------- ---------- ---------- --VQGECPGP EDV-VHNQKL ---------- ---------- ---------- --VQGGCPGL ADT-LSNQKL ---------- ---------- ---------- --VQGGVPDP EDV-VSNRKL ---------- ---------- ---------- --IQGEHPGP QDE-VSNQKL ---------- ---------- ---------- --VQDELLLQ NYQ-LQDEEL ---------- ---------- ---------- --VQDELLLQ NYH-LQDEEL ---------- ---------- ---------- --LQSELLLQ KYQ-PQDEEL ---------- ---------- ---------- --LQNELLSQ KDQ-LLSKEL ---------- ---------- ---------- --LLKKELMQ KVPPLQNKEL ---------- ---------- ---------- --CPEN---- EES--LQREL ---------- ---------- ---------- --MPNGKFLH AAN----REL ---------- ---------- ---------- --TDKEHLKK TKE-IATQEL ---------- ---------- ---------- ---------- ---EPYMDDG ---------- ---------- ---------- ---------- ---DTYMDDM ---------- ---------- ---------- ---------- ---DMYMDDV ---------- ---------- ---------- ---------- ---DTYMDDM ---------- ---------- ---------- ---------- ---DAYVDDM ---------- ---------- ---------- ---------- ---EAYMDDV ---------- ---------- ---------- ---------- ---DLYLEDV ---------- ---------- ---------- ---------- ---DPYLEDL ---------- ---------- ---------- ---------- ---QLYLDDL ---------- ---------- ---------- ---------- ---QLYLDDL ---------- ---------- ---------- ---------- ---QLYLDDL ---------- ---------- ---------- ---------- ---QFYLDDL ---------- ---------- ---------- ---------- ---QLYLDDL ---------- ---------- ---------- ---------- ---QLYLDDL ---------- ---------- ---------- ---------- ---QLYLDDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---DGYLEDL ---------- ---------- ---------- ---------- ---DPYLEDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---DNYLDDL ---------- ---------- ---------- ---------- ---DSYMDDI ---------- ---------- ---------- ---------- ---SSTADTT ---------- ---------- ---------- ---------D TSFTDEDKAL ---------- ---------- ---------- ---------D DVVYPKASPL ---------- ---------- ---------- ---------- ---------L ---------- ---------- ---------- -------GKI QFPNEEFREI ---------- ---------- ---------- -----KGGKM IYPEDDKKDV ---------- ---------- ---------- -----GEGSL TFSQSPEDGL ---------- ---------- ---------- -----GDGNI TFPQGSADGL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---GAILYFV ---------- ---------- ---------- ---------- ---GAILYFV ---------- ---------- ---------- ---------- ---DAILYFL ---------- ---------- ---------- ---------- ---GAVLYFL ---------- ---------- ---------- ---------- ---GGILYFL ---------- ---------- ---------- ---------- ---GGILYFL ---------- ---------- ---------- ---------- ---DAILYFL ---------- ---------- ---------- ---------- ---DAILYFL ---------- ---------- ---------- ---------- ---DAILYFL ---------- ---------- ---------- ---------- ---IPVVYLL ---------- ---------- ---------- ---------- ---IPVVYLL ---------- ---------- ---------- ---------- ---GPVFYLL ---------- ---------- ---------- ---------- ---GPVFYLL ---------- ---------- ---------- ---------- ---GPIFYLV ---------- ---------- ---------- ---------- ---GPILYLV ---------- ---------- ---------- ---------- ---APIFYLL ---------- ---------- ---------- ---------- ---DPILYLL ---------- ---------- ---------- ---------- ---DPILYLL ---------- ---------- ---------- ---------- ---PCVIYLL ---------- ---------- ---------- ---------- ---LHIISLL ---------- ---------- ---------- ---------- ---SHIMYLL ---------- ---------- ---------- ---------- ---DLILYLL ---------- ---------- ---------- ---------- ---DLILYLL ---------- ---------- ---------- ---------- ---DLNLYLL ---------- ---------- ---------- ---------- ---DLILYLL ---------- ---------- ---------- ---------- ---KAILDFL ---------- ---------- ---------- ---------- ---KAILDFL ---------- ---------- ---------- ---------- ---ESILDIL ---------- ---------- ---------- ---------- ---ETIWDVL ---------- ---------- ---------- ---------- ---EAISDFL ---------- ---------- ---------- ---------- ---EALWDVL ---------- ---------- ---------- ---------- ---EAISYTL ---------- ---------- ---------- ---------- ---EAISYTL ---------- ---------- ---------- ---------- ---GGITYVL ---------- ---------- ---------- ---------- ---EAVVYFL ---------- ---------- ---------- ---------- ---DPVLYTL ---------- ---------- ---------- ---------- -DEKLLIPDE ---------- ---------- ---------- -------FTL QEADVVVYPT ---------- ---------- ---------- ---------- --IKFPTNDD ---------- ---------- ---------- ---------- --IMVALNSL ---------- ---------- ---------- ---------- --VDGLDQHM LAALHLIVSA MDEMTDECLA LLRTCCSSAA LHTLELLVRH LAGEGEMPPS LTALYLTVSA MDEMTEECLA LLKTCCSPEA LRTLELCVSN DR-MNKAPRT LKALHLLISA LDEMTNDCLA ALGMCCSPAV LGILELLVQC ASRNGESPLS LLALHLVISA LD-------- ---------- -------VQC VTEAGEMSLS LSAFHLITSA LEEMPSDCLT ILRTSINLKV LQTLELLVQC VSGSRKKPLS LTATHLLISA LDEMSKPALF LLKSCCSYTT LQALLHLVQN MALNEKSSLK MNAAHLLVSA LEELPDETLN LLGRS-PPEF LEAFDKLLSS LKEGSEPLTV MEAVHLLVSA LEELPDETLD LLSRS-TPEF LEAFDNLMSS IRESSGPLTV LKAVYLLVST MDELPDEALG LLSES-RPVV LLAFDELLSS LKGSGGSISI MYAMQMLLCA LEELTDAGLK LLEPFCTSEH LSSLQDLVIH LT-SIMPLCK FMTAYFLVSA LAEMPDSAAA LLGTCCKLQI IPTLCHLLRA LSDDGVSDLE FMTAYFLVSA LAEMPDNAAA LLGTCCKLQI IPTLCHLLCA LSDDGVSDLE FSTAFFLVSA LAEMPDNAAA LLGTCCKLQI IPLLYHLLRA LSHDGVSDLE LSTAYFLVSA LAEMPDNAAG LLGTCCKLQI IPTLCHLLHA LSDDGVSDLE FSTAYFLVSA LAEMPDNAAA LLGACCKLQI IPTLCHLLRA LSDDGVSDLE FSTAYLLVSA LAEMPDNAAV LLGTCCKLQI IPTLCHLLYA LSDEGMSDLE FATAYFLVSA LAEMPDNATV FLGTCCKLHV ISSLCCLLHA LSDDSVCDFH LSAVHLLISA ISELSDYTLV LLRACSDLQV VPALCCLPYI ASADGTLALS LSAAHLLISA ISELSDYTLV LLRACSDLQV VPALCCLPYI ASADGTLALS FSAAHLLISA VSELPDDTLV LLRACCDLQV VPALCCLPNV ASADGTVALS ISAAHMLISA VAELSDCTLA LLHACCDTHM VSALCCLPNV ASADGTLTLR LLAAHFLLSA VAELSDYALV LLRACCDLQV LRILCRLPDM ASRDGTLTLE LTATHFLLSA LEELSDESLV LLGTCCDLQV LPVLQHLFTS TLDDGSASLK LVALHILTSA LNELSDSALA VLGTCCELQL LPVFSALMNM SSDEGLCSTT FTTVFYFISA LDDMSDACRT VLGICCEMQV IPTLWHLINN LSDDGTLPID ATDDYEKAAS MTDLSSAY-- ---------- -------LRE GSHTRIN--- VTDYYEKAAS MTDVSTAY-- ---------- -------LRE SSHTRVN--- VTDYYEKAAS MTDLSSAY-- ---------- -------LRD EKHTRVN--- VTDYYEKAAS MTDISTAY-- ---------- -------LRE SSHTRVN--- VADYYEKAAS MTDVSTAY-- ---------- -------LRE QGHTRVN--- AADYYEKAAS MTDVSTAY-- ---------- -------LRE HSHTRVN--- VADYFEKATS MTDISTSY-- ---------- -------LRD NSHTRAN--- VADYYEKATS MTDISTTY-- ---------- -------LSD NAHTRVN--- FSDYYDKPLS MTDIS----- ---------- -------LKE GTHIRVN--- FSDYYDKPLS MTDIS----- ---------- -------LKE GTHIRVN--- FSDYYDKPLS MSDIS----- ---------- -------LKE GTHIRVN--- FSDYYEKPLS MSDIS----- ---------- -------LKE GTHIRVN--- FSDYYDKPLS MTDIS----- ---------- -------LKE GTHIRVN--- FSDFYDKPLS MTDIS----- ---------- -------LKE GTHIRVN--- FSDYYDKSLS MSDIS----- ---------- -------LKE GTHIRVN--- ---------- ---------- ---------- ---------- ---------- FTDYYEKAAS MTDLSTSY-- ---------- -------LRE GAHARIN--- FADYYEKAAS MTDLSTSY-- ---------- -------LRD GSHIRIN--- ---------- ---------- ---------- ---------- ---------- FADYYEKAAS LTDISASY-- ---------- -------FRE GAHIRVN--- FSDYYEKAAS MTDISTTF-- ---------- -------MRE GAHTRVN--- TVDFYEQTAT LTDLSGPSGV GASSTSNVGG RGGGFPPEEP GAHQRVN--- IRSLDALFDG LIELSDEQCL ALKECNS-NF APAILHVLEQ GIAGNPVPLD LDATRVLFEA LIELDGEEIL DFRECNS-NL AKPLLHVLNQ ALHGRDVPLD EFARQILVNP LVT------- ---------- ---------- ---------- VLPCNALAIS LCDLSDAQCA ALKDVTP-GY LEPLLYLIRN AMYGRSTKED VLSCCGLATS LHGLTNLQNI ALKDVTP-EY CDQLLYLIRN AICGKNTPAD LQCCTALAEA LVELSATQCQ TLKEVTS-QY LEPLLYLLKN TMFGKMTSID LHCCTALTEA LVELSAPQCL ALKEVTS-EY LEPLLYLLKN VMYSKDTSVD ---------- ---------- ---------- ---------- ---------- GALT-ELSEA QQKLLVKSME KKILPVQLKL VESTMEQNFL LDKEGVFPLQ GALT-ELSEA QQKLLVKSME KKILPVQLKL VESTMEQNFL LDKEGVFPLQ GALA-ELSEA QQKLLVKSME KKILPVQLKL VESTMEQNFL QDKEGVFPLR GALT-ELSEA QQKLLVKSME KNILPVQLKL VESTMEQHFL QDKEGVFPLQ GALT-ELSEA QQKLLIKSVE KKILPMQLKL VESTMEQSFL QDKDGVFPLQ GALT-ELSEA QQKLLIKSVE KK-LPMQLKL VESTMEQSFL QDKDGVFPLQ GALT-VLSEA QQKLLVKSLE KKILPVQLKL VESTMEKNFL QDKEGVFPLQ GALT-ELSEE QLKILVKSLE NKVLPVQLKL VESILEQNFL QDKEDVFPLR GALT-ELTEE QLKILVKSLE KKILPVQLKL VESTLEQNFL QDKEGVFPLQ GALT-MLSET QHKLLAEALE SQTLLGPLEL VGSLLEQSAP WQERSTMSLP GALT-MLSET QHKLLAEALQ SQTLLGPLEL VGSLLEQSAP WQERSTMSLP QALA-VLSEA QHVLLAEVLE MGALSGTFWL VESLVEQSSP WQEHRAVSLP QALA-VLSAT QHVLLAEVLE MGALSGAFKL VESLLEQSTP WQEHRAVSLP QALA-VLNET QHVLLAKVLE TGALSGALTL VGSLLEQSAP WQERRAVSLP EALA-VLSES QHELLVEMLE TEGLSGQLKL VGSVLEQSTP WQERRHVSLP GALA-VLSET QQQLLAKALE TTVLSKQLEL VKHVLEQSTP WQEQSSVSLP EAIM-VLSDF QHDLLACSME KRILLQQQEL VRSILEPNFR YPWSIPFTLK EAIM-VLSDF QHDLLACSME KRILLQQQEL VRSILEPNFR YPWSIPFTLK EALL-VLSDI QHELLAWSME KRILPQQREL VESILEPNFR YPWNIPFTLD KAIL-GLSDT QHELLAWSME KRILLQQRAL VKSILEPNFK YPWNIPFTLD EAIV-ALSDT QHELLAWSME KRILLQQREL VRSILEPNFR YPWSIPVRLQ QALM-VLSDS QLNLLARSVE MRLLPHQVEL VTSILQPNFK YPWNIPFTVQ QALM-VLSDS QLNLLAQSVE MGILPHQVEL VKSILQPNFK YPWNIPFTLQ QALL-VLSDT QLCLLAQSVK MGLLPHQVEL VKSILQTNFK YSSNTPFTLQ QALM-VLSDT QLCLLALSVE MRLLPHQVEL VKSILQPNFK YPWNIPFTLQ DALL-ELSEE QQFVAEALEK GTLPLLKDQV K-SVMEQN-- ---------- DALL-ELSEE QQFVAEALEK GTLPLLKDQV K-SVMEQN-- ---------- DALI-T-SEE QHLVAEALEK GTLPLLKDQV RQSVLEQN-- ---------- DALM-ELSEY RQFVAEVLDK GELRPVK-DK VESILEEN-- ---------- DDLI-ELSEE GQLVAEALVK GTLP------ VEPILEQN-- ---------- DALE-ELSEE RRFVAEALEN RTLPLLK-GE MESILEQN-- ---------- DAFS-ELTED QLLLLLESWE VKIVPQQLKL VRSILEQNAE HS----TAAG DAFS-ELTED QLLLLLESLE VEIVPQQLKL VRSILEQSAE LG----AAAG DALHAELMDD QLLLLLESLE RKILSQQLKL VENLLKHDLD KGKS-FHVDA EALD-ELQEQ QLMLLEESVG KNIVSMQLEL VENILGNILS ND----KMKF HALE-ELTED QLLRLAQSVE KKIVPKQLEL VKSILKQEAS SL----DANI SSSMFNACHF LLTLLHELDE DNILDVLAQC LMVTKTTLNT VPVLRKLKES SSSELFEACE LLITLLNGLD DDQLSIISAC IEETGISQDI LCLLRPVWDT DYLVKGCIGW IDAILDTDKN LRHYLVQFSD EHLKLLLHIV ESKILNKEIN LVGHGGKQTT QEILREKLGC SDLNDTKPLL QVAGFSFEIA EALAAERLPL LGCALYYLEL MSFLSNDEIV AITDCSSTRH VVSSFLKVFS CSLMKKDIGK G------GDE DVYERAERLF AAANVSLKRG -GGALRVEVK QQPGQLPLVL CLYF--LKSR TVDERAERLF ASSGMSLRRG EGGVLRAEVG QQPRHLPLVT TEAS-SVLTE AIYEKIEHLF ATCNVSLRRN -GDMVKAEID KQPGNLPLVL SGDL-APLTG DTYQRTELLF ASCGVSLKRD -GGGQRSSAS SRP---TLIL S----LELEA NIYKETKHLF ESMNVSLTNK -DDVLCTKVT PHSGNLPLIL DAALDVLADE VVFKNITSLF NSCNVMLLKD -DNSLITKIS NPEDRLPLML ESLPALLQEN RNFQLAEQLF TTASVTLRRD -ANRMWVETE SKAGLHTLLL QSLPVLLQQN QNFQLAEQLL TTANVTMRRD -ANQLCVETG SGAELYMLLL DSIPVPLQDN QAFQQAEQLF YSIGVALRRD -AEQLWMESG REDEVLLLLL NTVPVSLQNE DEFHRKEELF KSCNVLLKKE -NDSLTSEVT CSVGFLPLVL DPTLTPLKDT ERFGIVQRLF ASADISLERL -KSSVKAVIL KDSKVFPLLL DPTLTPLKDT ERFGIVQRLF ASADISLERL -KSSVKAVIL KDSKVFPLLL DPALAPLKDR EKFGIVQRLF AATDINLERM -QSSVKAASR EDPNVLPLIL DPVLAPLKDT ERFGIVQRLF ASADINLERL -QPSVKVATR KDPNVFPLIL NPDLAPLKDM EKFMIVQRLF ALANMNLERL -QSSVKVVTQ KDPSIFPLIL DPMLAPLKDA ETLEIVQHLF ALADINLEML -QSSVQATAS KDPAVLPLIL NPTLAPLRDT ERFGIVQRLF ASADIALERM -QFSAKATIL KDSCIFPLIL SPLVATLTDR GRFDVVQRLF ASANINLEKT -ESSVKAVTM REPRFFPLVL SPSVATLTDR RRFDVAQRLF ASANINLEKT -ETSVKAVTM REPRFFPLVL SPLVATLADR GKFEVVQRLF ASSNINLEMT -ESSVKAVTV KEPRFFPLVL EPALTPLTDT GRFHIVQRLF ALANINLEMT -ESSVKAVTM KAPSFSPFIL DPMLAPLADA GKFWLVQRLF ALSNINLEMT -ESSIRAVTT KKPRFFPIIL DPALSCLTDK GKFHIVQKLF TSSNINLEMA -ESSVKAIIS KQPGFFPLIL EPALMDFLDQ ERFYVSQKLF ALFNIELEIK -EDFIYAATA EDPGFLPLIL SPGLFMLKEE NKFYTAQRLF GLSHMQLERE -KSSIKVMTR KQPGVLPLIL ------LLNH NIAKGPCSLC GMGSQRRETV YGCLECSSGG QKYVRLHVVP ------LLKH NIPKGPCALC GMGNQKRETV YGCLECSSGA QKYVRLHVVP ------LLNH NIPKGPCALC GMGHQRRETV YGCLECTSGG NKYVRLHAVP ------LLKH NIPKGPCALC GMGNQRRETV YGCLECSTGG QKYVRLHVVP ------LLKH SVPKGPCSLC GLGSQRRETV YGCLECSSGG QKYVRLHAVP ------LLKH NIPKGPCSLC GLGNQRRETV YGCVECSSGG QKYVRLHAVP ------LLNH NIPKGPCTLC GMGNSKRETV YGCLDCSFNG QKYVRLHVVP ------LLNH NISKGPCVLC GMGSSRRETV YGCLECSFNG QKYVRLHVVP ------LLNH NIPKGPCILC GMGNFKRETV YGCFQCSVDG QKYVRLHAVP ------LLNH NIPKGPCILC GMGNFKRETV YGCFQCSVDG QKYVRLHAVP ------LLNH NIPKGPCILC GMGNFKRETV YGCFQCSVDG QKYVRLHAVP ------LLNH NIPKGPCILC GMGNLKRETV YGCFQCSVDG QKYVRLHAVP ------LLNH NIPKGPCILC GMGNFKRETV YGCFQCSVDG HKYVRLHAVP ------LLNH NIPKGPCILC GMGNLKRETV YGCFQCSVDG VKYVRLHAVP ------LLNH SIPKGPCILC GMGSFKRETV YGCFQCSADG QKYVRLHAVP ---------- ---------- ---------- ---------- ---------- ------LLNN NIPKGPCVLC GMGSSKRETV YGCLECSFNG QKYVRLHAVP ------LLNN NIPKGPCVLC GMGSSKRETV YGCLECSFNG QKYVRLHAVP ---------- ---------- ---------- ---------- ---------- ------LLNN NIPKGPCSLC GMGSSKRETV YGCLECSFNG QTFVRLHAVP ------LLNN NIPKGPCALC GMGNSKRETV YGCFECSFNG QKYVRLHAVP ------LLHQ GVSKGPCALC GLGARPRDTV YGCVECAWGG HKYVRLHAVP DPAISILYVK SNNPGQDFIE AMDFGIQDVG NKKALVTEDD GKTLYAAQQA D--IKALYTD -RNPAQSFLN EMDFHIKGLD TLNPPAGQSN --KMEAAYIA ---------- ---------- ---------- ---------- ---------- DPQLKRIFTH AANPGKSFLL SLGFAQVTE- QGSKVLALKP D-PLASLEDI DPRLKRIYTH SSNPGKSFLL ALGFQLTKQ- NGKDILALPP D-LECPLEDA DPLLQRLWTH SSNPAKKFLL SVGFDQVME- GNQKVLRLKW DFEHISLEDV DPLLQRVWTH SANPAKNLLL SLGFDQVITE GNNKLLQLTW DSEHISLEDT ---------- ---------- ---------- ---------- ---------- PELLSSLGDE ELTLTEALVG LSGLEVQRSG PQY--MWDPD TLPRLCALYA PELLSSLGDE ELTLTEALVG LSGLEVQRSG PQY--MWDPD TLPRLCALYA PELLSSLGEE ELTLTEALVG LSGLEVQRSG PQY--TWDPD TLPRLCALYA PELLSSLGEE ELTLTEALVG LSGLEVQRSG PQY--TWDPD TLPHLCALYA PDLLSSLGEE ELTLTEALVG LSGLEVQRSG PQY--TWDPD TLPRLCALYA PDLLSSLGEE ELTLTEALVG LSGLEVQRSG PQY--TWDPD TLPRLCALYA PDLLSSLGEE ELILTEALVG LSGLEVQRSG PQY--TWDPD TLPHLCALYA PDLLSSLGEE DQILTEALVG LSGLEVQRSG PQY--TWNPD TCHNLCALYA PDLLSSLGEE ELTLTEALVG LSGLEVQRSG PQY--AWDPD TRHNLCALYA PGLLGNSWGE G-APAWVLLD ECGLELGEDT PHV--CWEPQ AQGRMCALYA PRLLGSSWGE G-APAWVLLD ECGLELGEDT LHV--CWEPQ AQGRMCALYA PERLGDSWGS E-APGWALLE ACGLEPQVGT PQV--CWEPG ARGCACALYA HELLGSSWGS E-APTWVLLE ECGLEPQVGA PQV--CWKPE AQGCANALYA PTLLGSSWGS E-APIWALLE ECGLEPQVGT AQV--CWEPE AQSCTCALYA QELLGSSWDP E-APAWVLLE ECGLGVQVDV PQV--CWEPQ AQGRTCALYA TVLLGDCWDE K-NPTWVLLE ECGLRLQVES PQV--HWEPT SLIPTSALYA PELLAPLQSE GLAITYGLLE ECGLRMELDN PRS--TWDVE AKMPLSALYG PELLAPLQSE GLAITYGLLE ECGLRMELDN PRS--TWDVE AKVPLSALYG PKLLASLQDE GLAVTFGLLQ ECGLRVAPDN PKG--TWDLE AKKPLSALYG PKLLTPLQVE GLAITFSLLE ECSLRVAPDS PKG--TXDLE SKKPLFTLYG PELLAQLQEE GVAITFALLE ECGLRVEPGN LKA--TWDLE VKKPLCALYA PQLLAPLQGE GLAITYELLE ECGLKMELNN PRS--TWDLE AKMPLSALYG PQLLAPLQGE GLAITYELLE ECGLKMELNN PRS--TWDLE AKMPLSALYG PQLLAPLQGE GLAITYELLE ECGLKMELNN PRS--TWDLE AKMPLSALYG PQLLAPLQGE GLAITYELLE ECGLKMELNN PRS--TWDLE AKMPLSALYG ---------- ---------- --WDELASSP PDM--DYDPE AR-ILCALYV ---------- ---------- --WDELASSP PDM--DYDPE AR-ILCALYV ---------- ---------- --WSE---QP HDM--GWDPN AR-LLCALYV ---------- ---------- --RCE---GP LDV--SCDPE AR-TLCALYV ---------- ---------- --QGE---QP RDV--GCDPE AR-TLCALYI ---------- ---------- --LGE---KL GDE--GFDPE AR-TLWALYV LLPSFSQQQQ QQQLTTAVLE MSGVELQGSS AAVCKEENFP SLAA---LYA LLSSFSEQQQ QQ-LTTAVLQ LSGVELQGSG AAVCTEESFP SLSA---LYA RLLSFP-HEE ELMLTMELVE LSGVQLQEDG SAVPRDQPFE SVAA---LFV TADAQLLPKE EMIITGAMIE MSGVTIQKNE AHLTGTGEPE ALVP---LYV ISS---LQEE ELNITKAMIE MDGVKLQRNG LYPIKTGDMA AFAAFSALYV KDHDIKFTEE MIEKLTATPI NDLMFALEIV VKPSSLLVHV PSRSRLDLQA DTREVEMPSD SCLLQTDTGK KLSQAFGFEV TEFLLSLSED NVRDVQALYL EEIQINLMFS ENQSTKLFLN GIGFVFETEE EKEVMTYPSE DHQKLLDAFI DQPSVSNLFA GSRRAESLVF SLGFQLERTD GNWYLSYSTS EMVEDDLSPA DIVVPLLEYD WALKLLFCLG YDLSNVKKDS TIKSPKESFK AIEAVGKILY CIAIRGLASL AR-------- -------- CIAIRGLASL AQ-------- -------- CIVIQSLASL AQGV------ -------- CIVVKGLAAI S--------- -------- CISIRGLASL DTEAKSN--- -------- CIAVKGLASL APHV------ -------- YLSVHGLVLL AKSH------ -------- YLSVHGLLLL AKSETDFI-- -------- SFSMHGLSLL LTGC------ -------- CIAIHGLASL SAV------- -------- CITLNGLCAL GREHS----- -------- CITLNGLCAL GREHS----- -------- YISLSGLCAL GRAQ------ -------- YISLNGLSAL GRA------- -------- YISLNRLCAL GRAH------ -------- YISLNGLCAL GRAH------ -------- HITLSGLSTL SKEHEEELCQ SGHATGQD YVALCGLHSL SGTVEELF-- -------- YVALCGLHSL DGTVEELF-- -------- YVALYGFHAL GGNVSEL--- -------- YIALYGFYAL GGAV------ -------- YIALYGLCAL GSKTTQA--- -------- GIVVTGLAAL WIMHS----- -------- FIVITGLQLL KRD------- -------- CIALHGFAGL MGLNQ----- -------- CFDLWHKTLR ---------- -------- CFDLWHKTLR ---------- -------- C--------- ---------- -------- CFDLWHKTLR ---------- -------- CFDLWHKSLR ---------- -------- CFDLWHKTLR ---------- -------- CFDLWHKRLK ---------- -------- CFDLWHKRVK ---------- -------- CFDIWHKRMK ---------- -------- CFDIWHKRMK ---------- -------- CFDIWHKRMK ---------- -------- CFDIWHKRMK ---------- -------- CFDVWHKRMK ---------- -------- CFDIWHKRMK ---------- -------- CFDVWHKRMK ---------- -------- ---------- ---------- -------- CFDLWHKRVK ---------- -------- CFDLWHKRMK ---------- -------- ---------- ---------- -------- CFDLWHKRLK ---------- -------- CFDLWHKRMK ---------- -------- CFDLWHRKMK S--------- -------- VYGLWGGL-- ---------- -------- VLALWG---- ---------- -------- ---------- ---------- -------- YVATFVMCQK ---------- -------- YVAVFVMAS- ---------- -------- YVAVFVMCTK I--------- -------- YVAVFVLCSE ---------- -------- ---------- ---------- -------- GLSLLQQLTK AS-------- -------- GLSLLQQLTK AS-------- -------- GLSLLQLLTK AS-------- -------- GLSLMQLLSK AS-------- -------- GLSLLQLLTK AS-------- -------- GLSLLQLLTK AS-------- -------- GLSLLQLLSK NS-------- -------- GLSLLHLLSR DS-------- -------- GLSLLHLLSR KSNALTYCAL S------- SLALLSGLSQ EPH------- -------- SLALLSGLSQ EPH------- -------- CLALLLRLSQ LC-------- -------- CLALLFRLSR LC-------- -------- CLALLLRLSQ LC-------- -------- CLALLLGLSQ DCC------- -------- SLFLLSSLGQ KPC------- -------- TLSLLQQLAE A--------- -------- TLSLLQQLAE A--------- -------- SLSVLQQLAE A--------- -------- SLSVPQQLAK A--------- -------- ALSGLQQLVV A--------- -------- SLSFLQQLQK ANSSFKPSLR PGYI---- SLSFLQQLRK ANSSSKPSLR PGYI---- SLSFLQQLQK ANSSSKPSLS PGYI---- SLSFLQQLSE A--------- -------- VVSILLELAE GPTSVSS--- -------- VVSILLELAE GPTSVSS--- -------- ALSLLLQLGE KPTSVPS--- -------- VVSILLQLSE KPTSVSS--- -------- VVSILL---- ---------- -------- VVSILLQL-E KPTSVSS--- -------- ALHALHCL-- ---------- -------- ALHALHCLVG AGGRPARAD- -------- AMYALNLLSG SKGACSKGQ- -------- VLYVLNLLTQ KTT------- -------- ALYALHLLSR SE-------- -------- TYYILNSVLQ ---------- -------- IIFLVVGSSD TQQQ------ -------- NIYLLSA--- ---------- -------- GLLVIMCALW DQK------- -------- GLFILPLEVN K--------- --------