,Supplementary Dataset 4. Top regulators per GENIE3 subnetwork ranked by out-degree.,,,,, ,gene,outdegree,expression,fle1,fle2,subnetwork Ebf1,Ebf1,125,14814,-0.108262819,-4.596286191,A Nfia,Nfia,120,7468,-0.375518139,-4.164387447,A Zmat4,Zmat4,112,1693,-0.723002185,-4.617314873,A Foxn1,Foxn1,110,5649,-0.298980271,-5.141736071,A Hmg20b,Hmg20b,107,90818,-0.238281293,-4.324921942,A Stat4,Stat4,102,699,-0.838624183,-5.298172618,A Zhx2,Zhx2,101,2713,-0.482860021,-5.046328445,A Pax1,Pax1,98,35884,-0.855288562,-4.907948874,A Rb1,Rb1,90,3604,-0.537315832,-5.388958245,A Cers6,Cers6,86,7408,-1.144805858,-4.019287418,A Six1,Six1,85,47214,-0.292309352,-3.678849083,A Cux2,Cux2,83,3592,-0.293102854,-3.491708552,A Msrb3,Msrb3,79,869,-1.098552236,-5.197349207,A Nfkb1,Nfkb1,76,10800,-1.361864523,-5.539280893,A Glis1,Glis1,76,1102,-1.103117445,-4.691185611,A Foxo3,Foxo3,71,7462,-1.299306196,-4.89020033,A Dnmt3a,Dnmt3a,69,33848,0.40912026,-4.906683828,A Heyl,Heyl,63,3557,-0.005908366,-6.543097364,A Rel,Rel,62,2490,-0.95060233,-5.740207227,A Rufy3,Rufy3,61,6869,-0.040543236,-5.391324976,A Mef2a,Mef2a,56,14273,0.554818271,-3.361733238,A Nfib,Nfib,52,37890,0.578681793,-4.206845118,A Nfat5,Nfat5,49,21595,0.135426192,-3.471941222,A Stat1,Stat1,42,1787,-1.420114227,-5.908589511,A Zfp704,Zfp704,31,19672,0.829178637,-3.114225796,A Meox2,Meox2,29,1252,0.057127218,-4.953333466,A Ncald,Ncald,25,2939,-2.009933456,-4.255226098,A Irf1,Irf1,23,1741,-1.837627116,-5.580238545,A Prkaa2,Prkaa2,22,3298,-1.620091721,-3.848927395,A Sox6,Sox6,136,8173,2.311990792,-4.869956659,B Sox5,Sox5,104,11836,2.607380949,-3.980519188,B Mbnl2,Mbnl2,97,50407,3.333123718,-4.517259723,B Elf1,Elf1,87,13621,3.476335675,-5.429712208,B Trp63,Trp63,79,47240,2.079740585,-4.415888497,B Rarb,Rarb,69,21987,1.924317533,-3.283698104,B Hdac8,Hdac8,59,8209,3.543794128,-4.098841244,B Mecom,Mecom,57,9434,1.027035493,-3.671291898,B Ikzf2,Ikzf2,57,42929,3.983346371,-4.581059913,B Gtf2ird1,Gtf2ird1,56,19136,3.947002424,-4.046489918,B Smad3,Smad3,52,12913,3.739848307,-3.207768998,B Foxo1,Foxo1,52,10470,2.712060159,-4.952843313,B Klf5,Klf5,51,23432,3.123892078,-5.334844389,B Nr3c1,Nr3c1,50,16864,3.115271326,-4.826146739,B Hivep2,Hivep2,45,2340,3.453924932,-4.78232387,B Xpa,Xpa,42,14713,3.420897533,-3.608343006,B Foxp2,Foxp2,40,16963,1.485740747,-3.517365208,B Tcf7l2,Tcf7l2,31,43310,3.697837832,-2.601704806,B Mctp2,Mctp2,28,1884,3.760125124,-5.313685001,B Zeb2,Zeb2,27,2441,2.536998229,-5.666339054,B Nr2c1,Nr2c1,26,7830,4.063092226,-3.657722869,B Gata6,Gata6,25,1854,-0.913208111,-3.173191623,B Plagl1,Plagl1,22,30999,3.852777702,-3.8321496,B Canx,Canx,74,179977,3.029435089,0.936181257,C Luzp1,Luzp1,46,85887,3.866065774,-0.282685913,C Pds5a,Pds5a,45,30711,3.99514829,0.257976566,C Nrf1,Nrf1,42,30105,4.23464049,0.064930882,C Suz12,Suz12,40,18575,4.125085385,1.168180658,C Spats2,Spats2,38,20373,2.557165695,0.796107589,C Rbfox2,Rbfox2,38,36098,3.137713163,0.182626798,C Ncor1,Ncor1,38,41455,3.214400771,-0.110646525,C Bclaf1,Bclaf1,37,103948,3.527451312,0.341007327,C Ube2k,Ube2k,34,111971,3.299205286,0.635420224,C Trim33,Trim33,34,15180,2.837680815,0.116895786,C Snd1,Snd1,30,28973,3.370910789,0.860547056,C Zfp148,Zfp148,30,28331,3.289737651,-0.746280636,C Rcor1,Rcor1,30,11309,3.409783687,-0.482305345,C Mapk1,Mapk1,30,38131,2.753963239,0.320227531,C Cbfa2t2,Cbfa2t2,30,14273,2.927733633,-0.152031073,C Cux1,Cux1,27,38146,2.465678932,-0.949657458,C Chd1,Chd1,26,46521,3.942205723,0.845391576,C Ywhae,Ywhae,23,775312,4.799922911,0.603178189,C 2810403A07Rik,2810403A07Rik,23,NA,3.683794938,0.494585846,C Smarcc1,Smarcc1,22,182319,3.738598592,-0.111148362,C Zfp423,Zfp423,100,5066,1.173853246,0.172005545,D Lin28b,Lin28b,76,6022,0.594928034,0.602706805,D Emx1,Emx1,71,17072,-0.477352813,0.042644355,D Arid3b,Arid3b,68,32568,0.235151319,0.810970734,D Nuak1,Nuak1,67,24585,-0.015983637,-0.700562915,D Prdm1,Prdm1,63,7441,-0.84360653,0.612919447,D Zbtb16,Zbtb16,61,8389,0.540199312,-0.945715536,D E2f3,E2f3,61,11428,2.02301693,1.37871986,D Smad6,Smad6,56,2666,-0.287278182,0.44344887,D Dab2,Dab2,53,20218,-0.912634336,-0.233267538,D Kdm2b,Kdm2b,39,23062,0.749622051,1.27137334,D Gata3,Gata3,39,29319,-1.575883489,0.289756679,D Hoxb3,Hoxb3,37,2962,-2.217129887,0.773426714,D Lin28a,Lin28a,34,18038,0.43267876,1.410925391,D Prdm6,Prdm6,32,501,-0.518781351,-1.421778572,D Arg1,Arg1,30,31385,-1.622576495,-0.429505578,D Nuak2,Nuak2,28,4181,-0.404058116,1.262279783,D Etv5,Etv5,26,17030,0.284696997,-0.277144974,D Etv1,Etv1,24,7638,-1.188431925,0.587175895,D Cers3,Cers3,61,2449,3.122008048,-6.216385375,E Anxa1,Anxa1,50,22396,3.443944539,-6.216344324,E Grhl3,Grhl3,48,15323,3.521812322,-7.046682694,E Elf5,Elf5,45,4237,2.846193896,-7.182860907,E Arid5b,Arid5b,42,12439,1.647338641,-5.077280413,E Celf4,Celf4,38,11206,3.523099269,-7.425048878,E Tfap2c,Tfap2c,37,5325,4.162035231,-7.13405639,E Tfap2a,Tfap2a,37,9537,4.671413665,-6.642133375,E Rarg,Rarg,36,11283,3.630142411,-5.971340729,E Lef1,Lef1,35,12604,2.992607513,-3.475572501,E Ovol1,Ovol1,32,4362,3.89551043,-7.511289634,E Pitx2,Pitx2,31,11849,4.412362535,-5.578710553,E Pitx1,Pitx1,31,29528,4.505026748,-6.130748175,E Barx2,Barx2,31,17890,4.496979308,-7.143782923,E Bcl11b,Bcl11b,29,19571,2.757602293,-5.428018643,E Sim2,Sim2,27,245,4.415271304,-4.119040017,E Tfap2b,Tfap2b,25,5281,4.610554982,-7.676721835,E Grhl1,Grhl1,25,1830,1.835418734,-7.891494493,E Rreb1,Rreb1,24,9624,1.978177161,-4.921883857,E Etv6,Etv6,58,6219,0.710041634,-2.55491693,F Tcf4,Tcf4,56,71970,1.097698209,-0.862704776,F Bcl11a,Bcl11a,48,40041,1.75082279,-3.906178348,F Zfhx3,Zfhx3,46,94353,1.881352448,-1.422446946,F Foxn3,Foxn3,42,15935,2.108180533,-2.295842682,F Tcf12,Tcf12,42,52831,2.512376298,-1.130902767,F Zbtb20,Zbtb20,41,13795,0.982461178,-2.205626372,F Trps1,Trps1,40,14958,2.379282865,-4.138294888,F Runx1,Runx1,36,11071,0.897492607,-1.800316134,F Zfp266,Zfp266,30,34974,2.750282652,-2.121441661,F Nf1,Nf1,30,6864,1.951282297,-0.842446785,F Klf12,Klf12,29,91,2.664783732,-2.790072794,F Phf21a,Phf21a,29,24689,1.495275846,-1.535240844,F Bach2,Bach2,26,13043,2.031888682,-2.65756964,F Foxp1,Foxp1,25,106682,3.135882574,-2.556637966,F Thoc2,Thoc2,23,55262,3.001516838,-0.576444552,F Gtf2i,Gtf2i,23,78085,2.999631056,-1.324201922,F Nr2f2,Nr2f2,99,130710,0.893986482,-2.648881439,G Tcf7l1,Tcf7l1,88,17831,1.994697938,-2.004970766,G Ctbp2,Ctbp2,62,34543,2.310956659,0.366621176,G Tead1,Tead1,55,30031,3.394679638,-1.180772392,G Ssbp3,Ssbp3,47,40694,2.397072769,0.025876005,G Nr6a1,Nr6a1,43,5968,3.448314172,-1.355858626,G Zfp532,Zfp532,35,11601,1.962930688,-0.246972112,G Pou6f2,Pou6f2,34,2009,1.764991815,-2.908191597,G Foxp4,Foxp4,34,25158,2.340634813,-0.675043295,G Fhl2,Fhl2,31,11150,1.394893874,-3.125270821,G Msi2,Msi2,30,50413,3.076560525,-1.591125013,G Pknox2,Pknox2,29,3621,1.606353311,-0.615090407,G Zfp697,Zfp697,28,8885,1.724401545,0.849323536,G Grhl2,Grhl2,27,14345,3.737560195,-1.400811382,G Tead4,Tead4,25,5264,2.088407807,-1.53580315,G Rbms1,Rbms1,23,119010,3.996799334,-1.353540291,G Zfp207,Zfp207,22,144242,3.83136043,5.04650319,G Gli3,Gli3,107,19579,-0.095241389,-0.918270959,H Zmiz1,Zmiz1,68,24505,-0.40150937,-0.772752745,H Pax8,Pax8,61,8075,-1.285781599,-2.058278054,H Zfp521,Zfp521,58,6815,-0.526463605,-1.78615362,H Hivep3,Hivep3,57,1037,-0.603095335,0.266220887,H Fli1,Fli1,48,640,-1.562242875,-2.570613903,H Nkx2.1,Nkx2.1,41,6422,-1.551448867,-1.605565303,H Tbx3,Tbx3,40,9484,-1.037284762,-1.457811065,H Esrrb,Esrrb,36,284,-1.994502639,-0.738740652,H Luzp2,Luzp2,35,1022,-2.441415807,-1.713181592,H Hhex,Hhex,33,20507,-2.236845131,-1.267856325,H Dusp22,Dusp22,33,7798,-2.041005465,-2.409522897,H Rora,Rora,32,3384,-0.893473641,-1.084950609,H Tbx20,Tbx20,27,340,-0.298516075,-2.233662459,H Nr4a2,Nr4a2,23,4892,-1.882265433,-2.072441805,H Zfp407,Zfp407,58,4839,3.642909076,-0.673815058,I Esrp1,Esrp1,49,41612,4.136926195,-2.29342457,I Terf1,Terf1,45,25635,5.220596957,0.088440956,I Kif22,Kif22,44,36191,5.73483639,0.642647468,I Rad21,Rad21,42,64592,5.204373189,0.492002411,I Pou2f1,Pou2f1,39,20244,4.795601581,-0.169164138,I Nup107,Nup107,35,13234,4.827200439,1.709318863,I Lcorl,Lcorl,33,8398,4.549833855,-1.490997739,I Ezh2,Ezh2,32,104686,4.477006331,1.7282204,I Myef2,Myef2,28,52959,5.281651775,0.782780069,I Srbd1,Srbd1,26,10292,4.499483946,0.721803549,I Brca1,Brca1,25,8258,5.409828792,2.443540042,I Cnot4,Cnot4,24,39303,4.072465408,-0.445752092,I Ctcf,Ctcf,24,40858,4.997033685,1.241476663,I Ahctf1,Ahctf1,24,18977,5.028889771,0.965730912,I Meis1,Meis1,86,51053,0.379000089,-2.549811896,J Hmga2,Hmga2,64,247417,-0.715025099,-3.035833021,J Jazf1,Jazf1,61,1056,-1.067920301,-2.659127234,J Setbp1,Setbp1,56,4672,-0.230164488,-1.746292985,J Pbx1,Pbx1,55,117778,-0.028255416,-1.474854843,J Pax9,Pax9,55,54148,-1.235941551,-0.959285458,J Gli2,Gli2,46,4791,0.481874478,-0.539370648,J Tbl1xr1,Tbl1xr1,40,13714,0.074209001,-2.610941636,J Isl1,Isl1,34,117748,-0.771007382,-1.86820592,J Kdm7a,Kdm7a,32,12412,-0.023310367,-0.354525666,J Meis2,Meis2,22,220655,1.30484965,-2.305584678,J Esrrg,Esrrg,71,319,-2.636295579,-0.43287755,K Vdr,Vdr,36,543,-4.141679757,-1.285641503,K Esr1,Esr1,36,111,-3.22593932,-0.614569271,K Gcm2,Gcm2,35,3479,-2.368198794,-0.989772438,K Maf,Maf,34,3701,-3.430400129,-0.918449053,K Hif3a,Hif3a,25,2864,-1.419211158,-3.361625731,K Crem,Crem,25,9478,-1.026017103,-2.047059564,K Hmg20a,Hmg20a,49,10786,3.156051583,1.253022973,L Nap1l1,Nap1l1,43,337615,2.325321573,1.244277475,L Ar,Ar,36,239,1.400195046,2.205614751,L Etfb,Etfb,31,88541,1.852523451,2.449002266,L Gm3604,Gm3604,24,2349,1.789044482,2.057354523,L Zfp367,Zfp367,22,6666,2.662667787,2.873128721,L Pou2f3,Pou2f3,22,25,1.367990175,2.700552291,L