Protein Description Gene HI12_1 HI12_4 HI12_5 HI12_6 NC12_2 NC12_3 NC12_5 NC12_6 HI.vs.NC FC HI.vs.NC Pvalue HI.vs.NC log2FC HI.vs.NC UP.DOWN GO_NUM GO_Description KEGG_Description KEGG_EC KEGG_ko COG_Function_Description COG_Function_Class COG_Class_Description IPR_Term NP_001027719.1 neutrophil cytosol factor 4 [Takifugu rubripes] ncf4 38538.20703125 9591.4541015625 63363.84375 17737.1171875 0 0 0 0 Inf 0 Inf up 2 Molecular Function:protein binding (GO:0005515),Molecular Function:phosphatidylinositol binding (GO:0035091) neutrophil cytosolic factor 4 -- ko04145 Phagosome -- -- -- IPR000270 [PB1 domain] ; IPR001452[SH3 domain] ; IPR001683[Phox homologous domain] NP_001027870.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [Takifugu rubripes] st3gal1 0 0 24353.1328125 27807.01171875 10067.1533203125 0 8886.513671875 8562.1240234375 2.84346602110933 0.00126363119120402 1.50765056445545 up 2 Biological Process:protein glycosylation (GO:0006486),Molecular Function:sialyltransferase activity (GO:0008373) beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) 2.4.99.4 ko00512 Mucin type O-glycan biosynthesis ko00533 Glycosaminoglycan biosynthesis - keratan sulfate ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko00604 Glycosphingolipid biosynthesis - ganglio series ko01100 Metabolic pathways -- -- -- IPR001675 [Glycosyl transferase family 29] NP_001292535.1 metal transporter CNNM3 precursor [Takifugu rubripes] cnnm3 34245.03125 26266.3125 31072.619140625 29039.537109375 61744.92578125 53538.8046875 36587.33203125 65077.35546875 0.556000827889766 0.0105940195221408 -0.846841063752302 down -- -- metal transporter CNNM -- -- Hemolysin or related protein, contains CBS domains R General function prediction only ; IPR000644 [CBS domain] ; IPR002550[Domain of unknown function DUF21] XP_003961788.1 cytochrome c oxidase assembly factor 5 [Takifugu rubripes] LOC101063412 33306.109375 24502.53515625 33875.7890625 45388.95703125 60843.0234375 64134.51953125 67246.9921875 78570.2578125 0.50618916679398 0.00114809256032051 -0.982251462942207 down -- -- cytochrome c oxidase assembly factor 5 -- -- -- -- -- IPR018793 [Cytochrome c oxidase assembly protein PET191] XP_003962403.3 dual specificity protein phosphatase 23 [Takifugu rubripes] dusp23 382678.125 632981.875 523236.40625 565922.6875 898882.25 847921.8125 823526.6875 920627.9375 0.602934403459623 0.000937777693749841 -0.729927042929978 down 2 Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- -- Protein-tyrosine phosphatase T Signal transduction mechanisms ; IPR000340 [Dual specificity phosphatase, catalytic domain] XP_003962546.2 ATPase inhibitor B, mitochondrial-like [Takifugu rubripes] LOC101076253 398731.65625 369210.875 129241.171875 40874.1953125 321555.8125 581310 872229.1875 980336.0625 0.340439618034356 0.0391793764635586 -1.55452915711199 down 3 Cellular Component:mitochondrion (GO:0005739),Biological Process:negative regulation of ATPase activity (GO:0032780),Molecular Function:ATPase inhibitor activity (GO:0042030) ATPase inhibitor, mitochondrial -- -- -- -- -- IPR007648 [Mitochondrial ATPase inhibitor] XP_003963084.3 BLOC-1-related complex subunit 6 [Takifugu rubripes] borcs6 5707.50439453125 3661.294921875 3265.40063476563 0 0 8315.0556640625 0 7243.90380859375 0.541347252832067 0.043061247153036 -0.885373772138432 down -- -- BLOC-1 related complex subunit 6 -- -- -- -- -- IPR019314 [BLOC-1-related complex subunit 6] XP_003963326.2 cytochrome P450 3A30-like [Takifugu rubripes] LOC101069124 1561308 1131168 1134799.125 1216037.75 987024.8125 742710.6875 825470.8125 709319.5625 1.54488371914038 0.00980147790024596 0.62749825293043 up 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 3 subfamily A 1.14.14.1 ko00140 Steroid hormone biosynthesis ko00591 Linoleic acid metabolism ko00830 Retinol metabolism ko01100 Metabolic pathways Cytochrome P450 QV Secondary metabolites biosynthesis, transport and catabolism ; Defense mechanisms ; IPR001128 [Cytochrome P450] XP_003963551.1 acidic mammalian chitinase-like isoform X1 [Takifugu rubripes] LOC101065506 201741.296875 144411.296875 228109.484375 237248.234375 115012.1484375 125156.359375 158017.625 123606.890625 1.5552341178383 0.0196051507609339 0.637131773423757 up 4 Cellular Component:extracellular region (GO:0005576),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:chitin metabolic process (GO:0006030),Molecular Function:chitin binding (GO:0008061) chitinase 3.2.1.14 ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Chitinase, GH18 family G Carbohydrate transport and metabolism ; IPR001223 [Glycoside hydrolase family 18, catalytic domain] ; IPR002557[Chitin binding domain] XP_003963714.2 kynurenine 3-monooxygenase [Takifugu rubripes] kmo 377582.1875 308216.5625 456997.78125 448789.4375 244649.796875 175538.375 373252.75 190635.703125 1.61733947165954 0.0369168699846315 0.693622525241781 up 1 Molecular Function:FAD binding (GO:0071949) kynurenine 3-monooxygenase 1.14.13.9 ko00380 Tryptophan metabolism ko01100 Metabolic pathways 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases HC Coenzyme transport and metabolism ; Energy production and conversion ; IPR002938 [FAD-binding domain] XP_003963745.2 hyaluronan-binding protein 2-like [Takifugu rubripes] LOC101072985 94949.7578125 86472.4453125 62957.5703125 71724.625 119664.1953125 147697.421875 109669.4609375 101546.484375 0.66050818760961 0.0167154839450959 -0.598351649765646 down 3 Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:protein binding (GO:0005515),Biological Process:proteolysis (GO:0006508) hyaluronan binding protein 2 3.4.21.- -- Secreted trypsin-like serine protease O Posttranslational modification, protein turnover, chaperones ; IPR000001 [Kringle] ; IPR000742[EGF-like domain] ; IPR001254[Serine proteases, trypsin domain] XP_003963778.2 dnaJ homolog subfamily C member 9 [Takifugu rubripes] dnajc9 39839.3046875 273218.625 156390.71875 114273.046875 226307.25 1104593.125 687042.375 589826.9375 0.223839435710329 0.0353093010982214 -2.15946386424015 down -- -- DnaJ homolog subfamily C member 9 -- -- DnaJ-class molecular chaperone with C-terminal Zn finger domain O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] XP_003964261.1 calcium uniporter protein, mitochondrial isoform X1 [Takifugu rubripes] mcu 67637.734375 56257.78125 71952.140625 64591.76953125 21186.98046875 36767.828125 50475.36328125 54320.03515625 1.60024021186801 0.0248218877660779 0.67828848414949 up -- -- calcium uniporter protein, mitochondrial -- ko04020 Calcium signaling pathway ko04218 Cellular senescence ko04621 NOD-like receptor signaling pathway -- -- -- IPR006769 [Coiled-coil domain containing protein 109, C-terminal] XP_003964295.1 postacrosomal sheath WW domain-binding protein [Takifugu rubripes] wbp2nl 32760.3359375 51325.34765625 64848.39453125 50430.61328125 75498.4296875 115330.1796875 88075.875 83678.2578125 0.549846057767288 0.00940109710803344 -0.862900335854958 down -- -- -- -- -- -- -- -- IPR004182 [GRAM domain] XP_003964703.3 soluble calcium-activated nucleotidase 1 isoform X2 [Takifugu rubripes] LOC101076188 74768.4609375 50349.6015625 38344.44921875 61423.0078125 26795.8359375 32654.208984375 26560.76171875 38995.546875 1.79899271682332 0.0238733994118965 0.847189345886697 up 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:nucleoside-diphosphatase activity (GO:0017110) soluble calcium-activated nucleotidase 1 3.6.1.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism -- -- -- IPR009283 [Apyrase] XP_003965543.3 uncharacterized protein LOC101066195 [Takifugu rubripes] LOC101066195 0 0 0 0 2551.74169921875 13937.23828125 3409.56469726563 141964.125 -Inf 0 -Inf down 1 Molecular Function:protein binding (GO:0005515) coronin-1B/1C/6 -- -- Membrane protein involved in colicin uptake M Cell wall/membrane/envelope biogenesis ; IPR001680 [WD40 repeat] ; IPR015048[Domain of unknown function DUF1899] XP_003965772.1 CCR4-NOT transcription complex subunit 10 isoform X3 [Takifugu rubripes] cnot10 0 300361.0625 549113.125 368188.125 95814.1015625 0 54100 70927.8828125 5.51372654953305 0.0115364174710727 2.4630277193947 up 1 Molecular Function:protein binding (GO:0005515) CCR4-NOT transcription complex subunit 10 -- ko03018 RNA degradation -- -- -- IPR019734 [Tetratricopeptide repeat] XP_003966517.3 protein O-glucosyltransferase 1 isoform X1 [Takifugu rubripes] poglut1 32024.6015625 25990.447265625 27187.919921875 27883.33203125 22477.21875 15096.9765625 19594.20703125 16375.0791015625 1.53767945926441 0.00341598851418941 0.620754794115026 up -- -- protein glucosyltransferase 2.4.1.- ko00514 Other types of O-glycan biosynthesis -- -- -- IPR006598 [Lipopolysaccharide-modifying protein] XP_003966674.1 F-box only protein 3 isoform X1 [Takifugu rubripes] fbxo3 0 0 17902.06640625 24734.63671875 10275.8525390625 0 11490.6396484375 5592.3876953125 2.33763425116238 0.0383558655868319 1.22504922186635 up 1 Molecular Function:protein binding (GO:0005515) F-box protein 3 -- -- Uncharacterized protein affecting Mg2+/Co2+ transport P Inorganic ion transport and metabolism ; IPR001810 [F-box domain] ; IPR007474[ApaG domain] ; IPR018958[SMI1/KNR4-like domain] XP_003967167.2 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [Takifugu rubripes] LOC101077032 0 28952.46484375 29089.6328125 0 11003.1279296875 17772.404296875 0 12305.146484375 2.11932103403138 0.0177296690560698 1.0836021432193 up 1 Molecular Function:protein binding (GO:0005515) homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein -- ko04141 Protein processing in endoplasmic reticulum -- -- -- IPR000626 [Ubiquitin domain] XP_003967579.2 dihydrofolate reductase-like [Takifugu rubripes] LOC101062022 19082.158203125 24870.76171875 0 32742.048828125 15855.6982421875 12479.2060546875 0 13852.2666015625 1.81796899665629 0.0478003321236194 0.862327596258307 up 4 Molecular Function:dihydrofolate reductase activity (GO:0004146),Biological Process:glycine biosynthetic process (GO:0006545),Biological Process:nucleotide biosynthetic process (GO:0009165),Biological Process:oxidation-reduction process (GO:0055114) dihydrofolate reductase 1.5.1.3 ko00670 One carbon pool by folate ko00790 Folate biosynthesis ko01100 Metabolic pathways Dihydrofolate reductase H Coenzyme transport and metabolism ; IPR001796 [Dihydrofolate reductase domain] XP_003968137.1 LOW QUALITY PROTEIN: mitochondrial enolase superfamily member 1 [Takifugu rubripes] enosf1 59514.2890625 93249.2734375 62882.7109375 74553.9296875 46838.59375 29955.166015625 54255.734375 37625.53125 1.72046930156342 0.0169577230896865 0.782802150210702 up -- -- L-fuconate dehydratase 4.2.1.68 ko00051 Fructose and mannose metabolism L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily MR Cell wall/membrane/envelope biogenesis ; General function prediction only ; IPR013341 [Mandelate racemase/muconate lactonizing enzyme, N-terminal domain] ; IPR029065[Enolase C-terminal domain-like] XP_003968383.2 caseinolytic peptidase B protein homolog isoform X2 [Takifugu rubripes] clpb 33865.484375 49188.6875 60395.4140625 54716.23828125 35210.76171875 19711.623046875 27495.8515625 41468.4296875 1.59957346978533 0.0459799601688724 0.677687258199575 up 2 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524) ATP-dependent Clp protease ATP-binding subunit ClpB -- ATP-dependent Clp protease ATP-binding subunit ClpA O Posttranslational modification, protein turnover, chaperones ; IPR002110 [Ankyrin repeat] ; IPR003959[ATPase, AAA-type, core] ; IPR019489[Clp ATPase, C-terminal] ; IPR020683[Ankyrin repeat-containing domain] XP_003969018.2 tissue alpha-L-fucosidase-like [Takifugu rubripes] LOC101066044 31389.283203125 5173.49853515625 47940.81640625 23762.474609375 0 0 0 0 Inf 0 Inf up 2 Molecular Function:alpha-L-fucosidase activity (GO:0004560),Biological Process:carbohydrate metabolic process (GO:0005975) alpha-L-fucosidase 3.2.1.51 ko00511 Other glycan degradation Alpha-L-fucosidase G Carbohydrate transport and metabolism ; IPR000933 [Glycoside hydrolase, family 29] ; IPR031919[Alpha-L-fucosidase, C-terminal] XP_003969399.1 ceramide synthase 2-like [Takifugu rubripes] LOC101079149 34500.19921875 43971.44921875 39677.625 48440.1875 20032.11328125 20369.419921875 21715.41015625 30835.28515625 1.79220513158 0.00336794140923792 0.841735774324156 up 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:integral component of membrane (GO:0016021) ceramide synthetase 2.3.1.24 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways -- -- -- IPR001356 [Homeobox domain] ; IPR006634[TRAM/LAG1/CLN8 homology domain] XP_003969976.3 haptoglobin-like [Takifugu rubripes] LOC101064923 499661.65625 519793.15625 588837.875 413483.96875 205149.21875 265652.625 156352.953125 332589.75 2.106577904332 0.00231998383185459 1.07490126985943 up 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) haptoglobin -- -- Secreted trypsin-like serine protease O Posttranslational modification, protein turnover, chaperones ; IPR001254 [Serine proteases, trypsin domain] XP_003970592.1 26S proteasome non-ATPase regulatory subunit 10 [Takifugu rubripes] psmd10 497624.34375 579796.625 583971.75 351444.125 87418.9609375 182061.421875 59839.13671875 211891.515625 3.71913489008753 0.0013601958395809 1.89496707430946 up 1 Molecular Function:protein binding (GO:0005515) 26S proteasome non-ATPase regulatory subunit 10 -- -- Chromosome segregation ATPase D Cell cycle control, cell division, chromosome partitioning ; IPR002110 [Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] XP_003970900.2 H/ACA ribonucleoprotein complex subunit 2 [Takifugu rubripes] nhp2 446591.75 210420.03125 413565.71875 387841.5 358497.25 795465.125 720047.75 720250.625 0.562171323757645 0.0437895061513168 -0.830918230866339 down -- -- H/ACA ribonucleoprotein complex subunit 2 -- ko03008 Ribosome biogenesis in eukaryotes Ribosomal protein L7Ae or related RNA K-turn-binding protein J Translation, ribosomal structure and biogenesis ; IPR004038 [Ribosomal protein L7Ae/L30e/S12e/Gadd45] XP_003971004.2 rab GTPase-binding effector protein 1 [Takifugu rubripes] rabep1 23514.091796875 21299.318359375 24712.203125 23031.693359375 53430.27734375 65555.9140625 31732.392578125 51022.8203125 0.458791822943897 0.0292307107498074 -1.12408841648789 down 2 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:growth factor activity (GO:0008083) Rab GTPase-binding effector protein 1 -- ko04144 Endocytosis -- -- -- IPR015390 [Rabaptin, GTPase-Rab5 binding domain] ; IPR018514[Rabaptin coiled-coil domain] XP_003971379.1 vacuolar protein-sorting-associated protein 36 [Takifugu rubripes] vps36 23580.25390625 21391.345703125 0 0 58824.53515625 52430.89453125 89140.0078125 105355.3828125 0.294171571238374 0.0455313980917325 -1.76527026370982 down 2 Molecular Function:phosphatidylinositol-3-phosphate binding (GO:0032266),Molecular Function:ubiquitin binding (GO:0043130) ESCRT-II complex subunit VPS36 -- ko04144 Endocytosis -- -- -- IPR007286 [EAP30] ; IPR021648[Vacuolar protein sorting protein 36, GLUE domain] XP_003971380.3 erythrocyte band 7 integral membrane protein-like [Takifugu rubripes] LOC101075172 226673.8125 231287.53125 276716.65625 197869.671875 157815.375 110517.0390625 216875.984375 122158.953125 1.53539315123862 0.0307466792521155 0.61860811795251 up -- -- erythrocyte band 7 integral membrane protein -- -- Regulator of protease activity HflC, stomatin/prohibitin superfamily O Posttranslational modification, protein turnover, chaperones ; IPR001107 [Band 7 domain] XP_003971522.2 solute carrier family 22 member 2-like [Takifugu rubripes] LOC101072186 28720.0703125 25627.1484375 21326.74609375 26142.955078125 39711.8125 40808.671875 60315.71875 50908.99609375 0.531001142853744 0.00441205992927168 -0.913213128796438 down 3 Cellular Component:integral component of membrane (GO:0016021),Molecular Function:transmembrane transporter activity (GO:0022857),Biological Process:transmembrane transport (GO:0055085) MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 2 -- MFS family permease GEPR Carbohydrate transport and metabolism ; Amino acid transport and metabolism ; Inorganic ion transport and metabolism ; General function prediction only ; IPR005828 [Major facilitator, sugar transporter-like] XP_003972355.1 fascin-like [Takifugu rubripes] LOC101061207 57550.203125 71742.6640625 60062.90234375 88403.875 94565.5625 99643.734375 171646.5625 103645.234375 0.591605958386013 0.049234504448924 -0.757291512209232 down 1 Molecular Function:actin filament binding (GO:0051015) fascin 1/2 -- -- -- -- -- IPR022768 [Fascin domain] XP_003973219.2 urocanate hydratase [Takifugu rubripes] uroc1 945212.75 2168223.75 2457019 2249399.25 1172170.875 657305 1248979.125 996806.6875 1.91885953581478 0.0432226729646611 0.940249107364281 up 1 Molecular Function:urocanate hydratase activity (GO:0016153) urocanate hydratase 4.2.1.49 ko00340 Histidine metabolism ko01100 Metabolic pathways Urocanate hydratase E Amino acid transport and metabolism ; IPR023637 [Urocanase] XP_003973726.1 ADP-ribosylation factor-like protein 8B [Takifugu rubripes] LOC101071295 85839.15625 61902.96875 96956.3515625 90650.7890625 52176.046875 38859.54296875 58218.40234375 54620.640625 1.64487980186046 0.00941301642867278 0.717982164145598 up 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 8 -- -- GTPase SAR1 family domain R General function prediction only ; IPR006689 [Small GTPase superfamily, ARF/SAR type] XP_003973736.1 bactericidal permeability-increasing protein-like [Takifugu rubripes] LOC101073247 27803.71484375 16363.794921875 98128.59375 55971.875 0 0 0 0 Inf 0 Inf up 1 Molecular Function:lipid binding (GO:0008289) -- -- -- -- -- -- IPR001124 [Lipid-binding serum glycoprotein, C-terminal] ; IPR017942[Lipid-binding serum glycoprotein, N-terminal] XP_003973908.1 phospholipid phosphatase 3 isoform X2 [Takifugu rubripes] plpp3 43127.078125 41705.00390625 42563.3203125 31834.03515625 17998.6484375 17178.59375 24030.84765625 15319.4345703125 2.13651853797461 0.000645471402931238 1.09526183493525 up -- -- phosphatidate phosphatase 3.1.3.4 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko00600 Sphingolipid metabolism ko01100 Metabolic pathways -- -- -- IPR000326 [Phosphatidic acid phosphatase type 2/haloperoxidase] XP_003974073.2 cytochrome P450 2J1-like [Takifugu rubripes] LOC101075700 123483.890625 168470.34375 182774.03125 177971.578125 136925.484375 89513.8671875 100955.4140625 87575.8671875 1.57288201173724 0.0154385830916112 0.653410452402744 up 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily J 1.14.14.1 ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko01100 Metabolic pathways Cytochrome P450 QV Secondary metabolites biosynthesis, transport and catabolism ; Defense mechanisms ; IPR001128 [Cytochrome P450] XP_003974834.1 macrophage-expressed gene 1 protein [Takifugu rubripes] mpeg1 29721.919921875 37314.34765625 12840.509765625 32486.814453125 0 79213.0234375 100879.625 0 0.311960518021562 0.00395397884067014 -1.68056464291146 down -- -- -- -- -- -- -- -- IPR020864 [Membrane attack complex component/perforin (MACPF) domain] XP_003975501.1 protein THEM6-like [Takifugu rubripes] LOC101071842 0 31709.173828125 89772.8984375 68426.3828125 21468.611328125 18991.89453125 28918.759765625 3273.41723632813 3.48522949828024 0.0337186102717406 1.80125365900027 up -- -- -- -- -- Acyl-CoA thioesterase FadM I Lipid transport and metabolism ; -- XP_003976413.1 TOX high mobility group box family member 4 isoform X2 [Takifugu rubripes] tox4 11241.3134765625 13764.7451171875 36963.2734375 39396.0234375 0 158403.578125 120733.53125 79183.0078125 0.212167871562123 0.00660596755934619 -2.23672188843351 down -- -- -- -- -- -- -- -- IPR009071 [High mobility group box domain] XP_003976796.1 ADP-ribosylation factor-related protein 1 isoform X1 [Takifugu rubripes] arfrp1 8375.2177734375 31735.267578125 15326.728515625 23028.470703125 36084.7421875 60944.0078125 0 39538.63671875 0.430917401596985 0.0322943088740699 -1.21451673537905 down 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor related protein 1 -- -- GTPase SAR1 family domain R General function prediction only ; IPR006689 [Small GTPase superfamily, ARF/SAR type] XP_003976870.1 galactocerebrosidase [Takifugu rubripes] galc 188467.96875 153022.53125 181887.796875 225292.390625 121548.3359375 143160.328125 131088.921875 82381.0703125 1.56567148640901 0.0143564800315883 0.646781534054663 up 2 Molecular Function:galactosylceramidase activity (GO:0004336),Biological Process:galactosylceramide catabolic process (GO:0006683) galactosylceramidase 3.2.1.46 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04142 Lysosome O-Glycosyl hydrolase M Cell wall/membrane/envelope biogenesis ; IPR001286 [Glycoside hydrolase, family 59] XP_003977149.1 ragulator complex protein LAMTOR2 [Takifugu rubripes] lamtor2 73377.96875 63819.68359375 59063.5 79767.640625 38028.7109375 34913.71875 36239.7890625 48437.31640625 1.75123465942924 0.00182973020910607 0.808372412904601 up -- -- ragulator complex protein LAMTOR2 -- ko04150 mTOR signaling pathway -- -- -- IPR004942 [Roadblock/LAMTOR2 domain] XP_003977201.2 tetraspanin-8-like [Takifugu rubripes] LOC101067360 210775.875 200119.875 280025.6875 248926.078125 91689.0546875 145640.9375 140326.84375 135453.203125 1.83166853905683 0.0029189129469209 0.873158455223113 up 1 Cellular Component:integral component of membrane (GO:0016021) tetraspanin-8 -- -- -- -- -- IPR018499 [Tetraspanin/Peripherin] XP_003977745.2 transmembrane protein 106B isoform X1 [Takifugu rubripes] LOC101074539 36350.9296875 31637.9296875 42336.375 35781.07421875 18583.197265625 20810.0859375 28626.552734375 21167.205078125 1.63820109883624 0.00375050703208391 0.712112467165622 up -- -- -- -- -- -- -- -- IPR009790 [Protein of unknown function DUF1356, TMEM106] XP_003978053.1 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X2 [Takifugu rubripes] taf5l 0 0 0 0 4534.09912109375 33672.2578125 4366.8916015625 12142.67578125 -Inf 0 -Inf down 1 Molecular Function:protein binding (GO:0005515) transcription initiation factor TFIID subunit 5 -- ko03022 Basal transcription factors ko05168 Herpes simplex infection WD40 repeat R General function prediction only ; IPR001680 [WD40 repeat] ; IPR007582[TFIID subunit TAF5, NTD2 domain] XP_003978094.2 deaminated glutathione amidase isoform X1 [Takifugu rubripes] nit1 30169.265625 24957.0625 19583.58203125 12478.935546875 38533.58203125 27172.71875 35156.45703125 48017.640625 0.5856301206752 0.0361938783475922 -0.771938337318664 down 1 Biological Process:nitrogen compound metabolic process (GO:0006807) Predicted amidohydrolase R General function prediction only ; IPR003010 [Carbon-nitrogen hydrolase] XP_003978441.1 protein Dr1 [Takifugu rubripes] dr1 0 16537.61328125 15830.0869140625 11358.7021484375 28771.978515625 46051.171875 26947.451171875 0 0.429656518409164 0.0372324584170787 -1.21874431230555 down -- -- down-regulator of transcription 1 -- -- -- -- -- IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] XP_003978612.1 NEDD8-like [Takifugu rubripes] LOC101077379 148686.640625 181944.09375 130423.65625 117255.9765625 170526.1875 280805.3125 193498.046875 294980.6875 0.615348020307624 0.0379236233573832 -0.70052551343827 down 1 Molecular Function:protein binding (GO:0005515) ubiquitin-like protein Nedd8 -- -- Ubiquitin O Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] XP_011600668.2 GPI transamidase component PIG-T [Takifugu rubripes] pigt 25395.142578125 36432.6953125 36546.7109375 30110.25390625 25309.08203125 10386.94140625 24366.8125 18101.236328125 1.64378337783816 0.0282704628951228 0.717020189341937 up 2 Biological Process:attachment of GPI anchor to protein (GO:0016255),Cellular Component:GPI-anchor transamidase complex (GO:0042765) phosphatidylinositol glycan, class T -- ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko01100 Metabolic pathways -- -- -- IPR007245 [GPI transamidase component PIG-T] XP_011600743.1 RNA-binding protein 10-like isoform X1 [Takifugu rubripes] LOC101076635 166983.046875 70711.3359375 133484.390625 132206.234375 92514.7734375 21849.158203125 16112.8818359375 18974.978515625 3.36820991640444 0.0174989629623516 1.75198205405704 up 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) RNA-binding protein 5/10 -- -- -- -- -- IPR000504 [RNA recognition motif domain] ; IPR001876[Zinc finger, RanBP2-type] XP_011601963.2 pyridoxal-dependent decarboxylase domain-containing protein 1 isoform X4 [Takifugu rubripes] pdxdc1 29780.40625 15838.140625 22717.263671875 23652.939453125 50290.76953125 41540.328125 42694.50390625 25635.927734375 0.574349847955622 0.0279804109448495 -0.799998315894559 down 3 Molecular Function:carboxy-lyase activity (GO:0016831),Biological Process:carboxylic acid metabolic process (GO:0019752),Molecular Function:pyridoxal phosphate binding (GO:0030170) -- -- -- Glutamate or tyrosine decarboxylase or a related PLP-dependent protein E Amino acid transport and metabolism ; IPR002129 [Pyridoxal phosphate-dependent decarboxylase] XP_011602057.2 ran GTPase-activating protein 1-like isoform X2 [Takifugu rubripes] LOC101061032 37990.70703125 37010.65625 48300.93359375 38695.27734375 60135.2421875 49944.375 72057.6953125 62887.08984375 0.661148737306091 0.00752562715458773 -0.59695322642977 down 3 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Ran GTPase-activating protein 1 -- ko03013 RNA transport Leucine-rich repeat (LRR) protein K Transcription ; IPR001611 [Leucine-rich repeat] ; IPR009109[Ran-GTPase activating protein 1, C-terminal] XP_011602981.2 beta-hexosaminidase subunit beta isoform X1 [Takifugu rubripes] hexb 280869.65625 194127.390625 286637.4375 201633.0625 111423.953125 158987.65625 118093.8828125 100502.9375 1.96983832669423 0.00542984983382365 0.978077226205538 up 1 Biological Process:carbohydrate metabolic process (GO:0005975) hexosaminidase 3.2.1.52 ko00511 Other glycan degradation ko00520 Amino sugar and nucleotide sugar metabolism ko00531 Glycosaminoglycan degradation ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko00604 Glycosphingolipid biosynthesis - ganglio series ko01100 Metabolic pathways ko04142 Lysosome N-acetyl-beta-hexosaminidase G Carbohydrate transport and metabolism ; IPR015883 [Glycoside hydrolase family 20, catalytic domain] ; IPR029019[Beta-hexosaminidase, eukaryotic type, N-terminal] XP_011603116.2 golgin subfamily A member 2 isoform X1 [Takifugu rubripes] golga2 22527.0625 17436.26953125 19048.896484375 16751.123046875 32009.048828125 45995.03515625 26340.154296875 31380.029296875 0.558215217620456 0.0145004375737455 -0.841106640339507 down 1 Cellular Component:Golgi apparatus (GO:0005794) golgin subfamily A member 2 -- -- -- -- -- IPR024858 [Golgin subfamily A] XP_011603548.1 probable C-mannosyltransferase DPY19L1 [Takifugu rubripes] dpy19l1 48431.84765625 34125.6328125 40206.99609375 29407.91015625 20857.08984375 14561.146484375 22916.357421875 33932.97265625 1.64925111440288 0.0406096766133984 0.721811079746823 up 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- -- -- -- IPR018732 [Dpy-19/Dpy-19-like] XP_011603941.1 multidrug resistance protein 1 isoform X1 [Takifugu rubripes] LOC101067017 51708.81640625 39001.6328125 77546.21875 74876.453125 155689.59375 100246.96875 92322.8671875 93069.78125 0.550911009441843 0.0320841231015113 -0.860108800783702 down 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 1 3.6.3.44 ko02010 ABC transporters ABC-type multidrug transport system, ATPase and permease component V Defense mechanisms ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] XP_011604094.2 zinc finger protein 687a isoform X1 [Takifugu rubripes] LOC101068979 9794.6513671875 9719.544921875 7597.55517578125 0 14980.5224609375 0 15730.515625 19811.244140625 0.53662958738213 0.00939564457882856 -0.898001494271963 down 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- -- -- -- IPR007087 [Zinc finger, C2H2] XP_011605301.1 probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X3 [Takifugu rubripes] asmtl 68986.390625 63551.46875 57756.3046875 58866.4375 36855.359375 39991.34765625 46349.53515625 39132.27734375 1.53491575160047 0.000563747686597088 0.61815947117603 up 2 Molecular Function:O-methyltransferase activity (GO:0008171),Molecular Function:nucleoside-triphosphate diphosphatase activity (GO:0047429) -- -- -- Trans-aconitate methyltransferase C Energy production and conversion ; IPR001077 [O-methyltransferase, family 2] ; IPR003697[Maf-like protein] ; IPR031725[Acetylserotonin O-methyltransferase, dimerisation domain] XP_011606908.1 relA-associated inhibitor isoform X2 [Takifugu rubripes] ppp1r13l 20359.87890625 26639.16796875 25772.841796875 14352.2734375 31543.013671875 33798.78125 36643.9140625 34606.26953125 0.637842449140662 0.00648009591435292 -0.648727981105837 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ankyrin repeat T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR020683[Ankyrin repeat-containing domain] XP_011607293.2 nuclear pore complex protein Nup153 isoform X1 [Takifugu rubripes] nup153 33216.38671875 24804.65234375 35314.73828125 40546.0234375 41545.76953125 80870.2734375 65535.671875 53054.171875 0.555512575248786 0.0253357846427277 -0.848108524328414 down 1 Molecular Function:zinc ion binding (GO:0008270) nuclear pore complex protein Nup153 -- ko03013 RNA transport -- -- -- IPR001876 [Zinc finger, RanBP2-type] ; IPR013913[Nucleoporin Nup153, N-terminal] XP_011607527.2 mRNA cap guanine-N7 methyltransferase [Takifugu rubripes] rnmt 38774.328125 40876.9453125 53901.32421875 40114.0078125 21107.03515625 20911.09375 39524.13671875 26994.201171875 1.60007609049745 0.0272152580981773 0.678140513095852 up -- -- mRNA (guanine-N7-)-methyltransferase 2.1.1.56 ko03015 mRNA surveillance pathway -- -- -- IPR004971 [mRNA (guanine-N(7))-methyltransferase domain] XP_011607601.2 MAP7 domain-containing protein 1-like isoform X1 [Takifugu rubripes] LOC101067704 13327.373046875 18997.23828125 8232.171875 8716.3271484375 26083.04296875 30238.37890625 23414.74609375 22502.873046875 0.481940263348442 0.00484447875924639 -1.05307375986754 down 2 Biological Process:microtubule cytoskeleton organization (GO:0000226),Cellular Component:microtubule cytoskeleton (GO:0015630) MAP7 domain-containing protein 1 -- -- -- -- -- IPR008604 [Microtubule-associated protein 7 family] XP_011608399.1 transforming growth factor-beta receptor-associated protein 1 [Takifugu rubripes] tgfbrap1 23555.34375 9140.16796875 13599.625 20522.220703125 31262.32421875 36332.75390625 29080.31640625 29664.2109375 0.528871031170049 0.00662927540633672 -0.919012140744446 down 2 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192) vacuolar protein sorting-associated protein 3 -- -- -- -- IPR000547 [Clathrin, heavy chain/VPS, 7-fold repeat] ; IPR001180[Citron homology (CNH) domain] ; IPR019452[Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1] ; IPR019453[Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2] XP_011608473.1 cleavage and polyadenylation specificity factor subunit 7 isoform X1 [Takifugu rubripes] cpsf7 24651.544921875 14627.3076171875 19010.642578125 0 39415.25390625 32442.30859375 0 29039.1171875 0.577714700798117 0.0280015224459447 -0.791570888250359 down -- -- cleavage and polyadenylation specificity factor subunit 6/7 -- ko03015 mRNA surveillance pathway -- -- -- -- XP_011609161.1 inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 [Takifugu rubripes] ocrl 9791.9765625 0 12285.8662109375 0 6267.0400390625 6018.63525390625 7313.83251953125 6357.720703125 1.70109399469575 0.00650246588816505 0.766462859951848 up 1 Biological Process:signal transduction (GO:0007165) inositol polyphosphate 5-phosphatase INPP5B/F 3.1.3.36 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system -- -- -- IPR000198 [Rho GTPase-activating protein domain] ; IPR005135[Endonuclease/exonuclease/phosphatase] ; IPR031995[Inositol polyphosphate 5-phosphatase, clathrin binding domain] XP_011610542.2 apolipoprotein B-100-like [Takifugu rubripes] LOC101066597 52181.203125 74965.078125 71586.03125 73421.515625 43575.77734375 40945.0703125 36752.51171875 37484.421875 1.71427079656922 0.00222711922176887 0.777595024274826 up 2 Molecular Function:lipid transporter activity (GO:0005319),Biological Process:lipid transport (GO:0006869) apolipoprotein B -- -- -- -- IPR001747 [Lipid transport protein, N-terminal] ; IPR009454[Lipid transport, open beta-sheet] ; IPR015255[Vitellinogen, open beta-sheet] XP_011610678.2 sodium channel and clathrin linker 1 [Takifugu rubripes] LOC101063900 49206.3046875 28251.396484375 50296.1875 47969.984375 100223.7734375 71411.8203125 0 67124.34375 0.551989191173064 0.0206182779006187 -0.857288077872494 down -- -- -- -- -- -- -- -- -- XP_011611923.2 C-reactive protein-like [Takifugu rubripes] LOC105417795 305804.8125 363054.8125 159418.21875 281825 674995.875 436343.1875 530969.1875 376581.375 0.549858115076499 0.0267800107941667 -0.862868700037554 down -- -- -- -- -- -- -- -- IPR001759 [Pentraxin-related] XP_011612458.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2 [Takifugu rubripes] magi1 10380.0107421875 9883.3310546875 24124.6640625 24328.044921875 50767.36328125 59896.5625 41299.38671875 22607.166015625 0.393629274351216 0.0254128500041016 -1.34509057646934 down 1 Molecular Function:protein binding (GO:0005515) atrophin-1 interacting protein 3 (BAI1-associated protein 1) -- ko04530 Tight junction Guanylate kinase F Nucleotide transport and metabolism ; IPR001202 [WW domain] ; IPR001478[PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] XP_011612550.2 molybdenum cofactor biosynthesis protein 1 isoform X1 [Takifugu rubripes] mocs1 10487.64453125 1387.19812011719 7988.26513671875 0 17655.34375 16539.578125 21862.908203125 11847.5234375 0.390015548794013 0.0265600150283005 -1.35839645367951 down 4 Molecular Function:catalytic activity (GO:0003824),Biological Process:Mo-molybdopterin cofactor biosynthetic process (GO:0006777),Cellular Component:molybdopterin synthase complex (GO:0019008),Molecular Function:iron-sulfur cluster binding (GO:0051536) -- -- ko00790 Folate biosynthesis ko01100 Metabolic pathways Molybdenum cofactor biosynthesis enzyme MoaA H Coenzyme transport and metabolism ; IPR002820 [Molybdopterin cofactor biosynthesis C (MoaC) domain] ; IPR007197[Radical SAM] ; IPR010505[Molybdenum cofactor synthesis C-terminal] XP_011613196.2 serine/arginine-rich splicing factor 11 isoform X1 [Takifugu rubripes] srsf11 124835.4921875 85831.4453125 87460.4140625 112698.4453125 131153.578125 246718.53125 248274.65625 170394.953125 0.515761807830608 0.019771405435037 -0.955223149393808 down 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 11 -- -- -- -- -- IPR000504 [RNA recognition motif domain] XP_011613811.2 ataxin-2 isoform X1 [Takifugu rubripes] atxn2 17695.30859375 18190.623046875 17005.37890625 11481.28515625 23721.060546875 39171.73046875 45149.41015625 36148.00390625 0.446442223091691 0.00582124172414723 -1.16345461573924 down -- -- -- -- -- -- -- -- IPR009604 [LsmAD domain] ; IPR009818[Ataxin-2, C-terminal] ; IPR025852[Ataxin 2, SM domain] XP_011614081.1 pleckstrin homology domain-containing family A member 2 [Takifugu rubripes] plekha2 134141.828125 6930.09765625 0 25061.30859375 362946.96875 369920.75 358681.4375 247700.28125 0.165399344561357 0.00208951339729988 -2.59597457742747 down -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] XP_011615588.1 solute carrier family 12 member 6 isoform X1 [Takifugu rubripes] slc12a6 12932.4375 9750.244140625 16232.201171875 14950.201171875 0 24612.16015625 37136.41796875 18964.8984375 0.500521284781962 0.0378338050016404 -0.998496673585429 down 5 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 12 (potassium/chloride transporter), member 4/5/6 -- -- Amino acid transporter E Amino acid transport and metabolism ; IPR004841 [Amino acid permease/ SLC12A domain] ; IPR018491[SLC12A transporter, C-terminal] XP_011616981.1 lysocardiolipin acyltransferase 1 isoform X2 [Takifugu rubripes] lclat1 54734.44921875 12950.2841796875 8376.134765625 8380.7744140625 56032.9609375 54197.91015625 0 103192.140625 0.296740409684838 0.0456352798605342 -1.75272669054235 down 1 Biological Process:metabolic process (GO:0008152) -- -- ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways 1-acyl-sn-glycerol-3-phosphate acyltransferase I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] ; IPR032098[Acyltransferase, C-terminal domain] XP_011617650.1 phosphofurin acidic cluster sorting protein 1 [Takifugu rubripes] pacs1 52538.65625 24414.251953125 40505.19140625 40115.37890625 44839.56640625 68940.8671875 92690.25 93328.7265625 0.525596359357414 0.0329316959725926 -0.927972812292561 down -- -- -- -- -- -- -- -- IPR019381 [Phosphofurin acidic cluster sorting protein 1] XP_011618006.2 zinc finger protein 839 isoform X3 [Takifugu rubripes] znf839 20057.185546875 19201.775390625 11712.197265625 20320.47265625 20193.935546875 32704.75390625 34138.67578125 30133.654296875 0.608440817060239 0.0223527791696553 -0.716811155836864 down -- -- -- -- -- -- -- -- IPR031885 [Domain of unknown function DUF4764] XP_011618469.2 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [Takifugu rubripes] ndufv3 216826 132066.84375 167854.09375 242304.53125 218335.15625 349177 394037.3125 341554.625 0.582494884630164 0.023324429626791 -0.779682714564393 down 2 Cellular Component:mitochondrion (GO:0005739),Cellular Component:mitochondrial respiratory chain complex I (GO:0005747) NADH dehydrogenase (ubiquinone) flavoprotein 3 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways -- -- -- IPR026193 [NADH-ubiquinone oxidoreductase flavoprotein 3] XP_029682834.1 nck-associated protein 1-like [Takifugu rubripes] nckap1l 8927.52734375 0 9389.4072265625 0 3510.2109375 5034.6318359375 6126.48974609375 0 1.87272708998259 0.0232588793435713 0.905140672877325 up -- -- NCK-associated protein 1 -- ko04810 Regulation of actin cytoskeleton -- -- -- IPR019137 [Nck-associated protein 1] XP_029684178.1 inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [Takifugu rubripes] ror1 0 0 15968.8798828125 13932.8017578125 0 0 25785.658203125 23813.876953125 0.602862134623395 0.0200830858286223 -0.730099977398552 down 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) receptor tyrosine kinase-like orphan receptor 1 2.7.10.1 -- Ankyrin repeat T Signal transduction mechanisms ; IPR000001 [Kringle] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR013098[Immunoglobulin I-set] ; IPR020067[Frizzled domain] XP_029685364.1 dipeptidyl peptidase 2 [Takifugu rubripes] dpp7 53361.4921875 31791.755859375 34574.26953125 44062.3984375 16938.296875 34876.1796875 19544.83203125 16424.115234375 1.86584105373147 0.0274941595854073 0.899826091891542 up 2 Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236) dipeptidyl-peptidase II 3.4.14.2 -- -- -- -- IPR008758 [Peptidase S28] XP_029685423.1 uncharacterized protein LOC101080231 [Takifugu rubripes] LOC101080231 0 0 0 0 13703.638671875 23961.826171875 28173.31640625 26133.0703125 -Inf 0 -Inf down 1 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950) -- -- -- -- -- -- IPR012317 [Poly(ADP-ribose) polymerase, catalytic domain] XP_029687796.1 reversion-inducing cysteine-rich protein with Kazal motifs [Takifugu rubripes] reck 13136.52734375 9105.21484375 9996.4794921875 7066.21875 13819.4443359375 18100.03125 13827.0634765625 14215.41015625 0.655489705418 0.0196486752863562 -0.609354972043727 down 1 Molecular Function:protein binding (GO:0005515) reversion-inducing-cysteine-rich protein with kazal motifs -- -- -- -- IPR002350 [Kazal domain] XP_029687816.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [Takifugu rubripes] ppp2r5c 0 25236.056640625 27585.19921875 32866.9765625 9916.974609375 8669.45703125 8013.81884765625 0 3.22133178631626 0.00106323660868469 1.68765726110003 up 3 Cellular Component:protein phosphatase type 2A complex (GO:0000159),Biological Process:signal transduction (GO:0007165),Molecular Function:protein phosphatase regulator activity (GO:0019888) serine/threonine-protein phosphatase 2A regulatory subunit B' -- ko03015 mRNA surveillance pathway ko04114 Oocyte meiosis ko04261 Adrenergic signaling in cardiomyocytes -- -- -- IPR002554 [Protein phosphatase 2A, regulatory B subunit, B56] XP_029690896.1 peroxiredoxin-like 2A isoform X1 [Takifugu rubripes] LOC101063569 988001.5 913332.3125 1492159.5 1691974.5 447572.59375 453719.59375 292207.40625 495350.65625 3.01120114853286 0.0181105536940893 1.59033908345218 up -- -- -- -- -- -- -- -- IPR032801 [Peroxiredoxin-like FAM213/AAED1] XP_029691859.1 protein spinster homolog 1 isoform X1 [Takifugu rubripes] spns1 16211.7333984375 7810.259765625 12142.4921875 14622.2275390625 7820.0263671875 5762.3681640625 6365.03076171875 1587.98999023438 2.35828806748096 0.0180211233665658 1.23773995586754 up 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) -- -- -- Sugar phosphate permease G Carbohydrate transport and metabolism ; IPR011701 [Major facilitator superfamily] XP_029692049.1 immunoglobulin lambda-1 light chain-like [Takifugu rubripes] LOC115249829 39967.8125 32818.859375 46513.5234375 29967.755859375 77852.3984375 92359.640625 101044.1328125 45975.58203125 0.470532818149054 0.0160421666052645 -1.08763274509037 down -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] XP_029692057.1 immunoglobulin lambda-1 light chain-like [Takifugu rubripes] LOC115249835 18343.55078125 16988.22265625 16980.42578125 18930.05859375 50513.2109375 50379.8359375 49335.65625 26880.80859375 0.402249755651931 0.0193655091245682 -1.3138365503087 down -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] XP_029695971.1 protein N-lysine methyltransferase METTL21A isoform X1 [Takifugu rubripes] mettl21a 0 6912.85986328125 7115.896484375 6988.92724609375 16195.4326171875 9922.2197265625 10530.203125 10603.640625 0.593072821850962 0.0465581283930174 -0.753718834512402 down -- -- protein N-lysine methyltransferase METTL21A 2.1.1.- -- Predicted nicotinamide N-methyase R General function prediction only ; IPR019410 [Lysine methyltransferase] XP_029697275.1 protein tweety homolog 2 isoform X1 [Takifugu rubripes] ttyh2 0 0 17784.734375 23716.40234375 8249.9013671875 0 13924.6044921875 8067.3994140625 2.05845843756421 0.0489526723487673 1.04156431942656 up -- -- -- -- -- -- -- -- IPR006990 [Tweety] XP_029700059.1 leucine-rich repeat and calponin homology domain-containing protein 3 isoform X3 [Takifugu rubripes] LOC101061236 29878.69140625 13774.71875 17089.4296875 17243.8203125 27518.53125 27161.201171875 40644.80859375 37362.3515625 0.587749540598609 0.0325080126743712 -0.766726588659201 down 1 Molecular Function:protein binding (GO:0005515) -- -- -- Leucine-rich repeat (LRR) protein K Transcription ; IPR001611 [Leucine-rich repeat] ; IPR001715[Calponin homology domain] XP_029700120.1 LOW QUALITY PROTEIN: cdc42 effector protein 4 [Takifugu rubripes] cdc42ep4 30126.369140625 18314.677734375 26964.87109375 17998.248046875 55676.36328125 82997.875 40006.78515625 66099.953125 0.381582618581375 0.00738797237809055 -1.38993263805537 down -- -- -- -- -- -- -- -- IPR000095 [CRIB domain] ; IPR029273[Cdc42 effector] XP_029701243.1 renalase [Takifugu rubripes] rnls 0 0 65303.77734375 63490.09765625 33055.31640625 0 24796.97265625 0 2.22625374185037 0.0139093285073526 1.15461803618683 up 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Predicted NAD/FAD-dependent oxidoreductase R General function prediction only ; IPR002937 [Amine oxidase] XP_029703718.1 procollagen C-endopeptidase enhancer 2 [Takifugu rubripes] LOC101077796 268062.03125 358526.625 85575.6640625 296635.65625 476041.46875 475258.78125 429732.875 455898.3125 0.549176717197155 0.0363650378438796 -0.864657632359797 down -- -- -- -- -- Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain O Posttranslational modification, protein turnover, chaperones ; IPR000859 [CUB domain] ; IPR018933[Netrin module, non-TIMP type] XP_029705651.1 ATP synthase subunit ATP5MPL, mitochondrial-like [Takifugu rubripes] LOC115253001 71806.3125 128183.75 12362.580078125 8529.0390625 290668.90625 131142.125 0 331837.5625 0.219812340398822 0.0239083154756724 -2.18565571254732 down 1 Cellular Component:mitochondrion (GO:0005739) -- -- -- -- -- -- IPR012574 [Mitochondrial proteolipid] XP_029706051.1 myosin-10-like isoform X1 [Takifugu rubripes] LOC101062147 184344.21875 249195.1875 332151.46875 286375.5625 51875.4765625 133840.3125 171951.09375 131156.203125 2.15224376214203 0.012712744053512 1.10584148612756 up 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin heavy chain -- ko04530 Tight junction -- -- -- IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR002928[Myosin tail] ; IPR004009[Myosin, N-terminal, SH3-like]