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clearfix"> <div class="panel-display panels-960-layout jcore-2col-layout"> <div class="panel-row-wrapper panel-row-first clearfix"> <div class="top-wrapper"> <div class="panel-panel panel-region-top"> <div class="inside"> <div class="panel-pane pane-highwire-article-citation no-margin-bottom"> <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node38562" data-apath="/kidney360/early/2020/08/25/KID.0001212020.atom" data-hw-author-tooltip-instance="highwire_author_tooltip" data-node-nid="38562" data-pisa="kidney360;KID.0001212020v1" data-pisa-master="kidney360;KID.0001212020" id="node38562--21478237114"> <div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-asnjnls-styles-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a"> <div class="highwire-cite-overline"> <span class="highwire-cite-metadata-art-cat highwire-cite-metadata">Original Investigation</span> </div> <h1 class="highwire-cite-title" id="page-title">Functionally Essential Tubular Proteins are Lost to Urine-Excreted, Large Extracellular Vesicles During Chronic Renal Insufficiency</h1> <div class="highwire-cite-authors"> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Ryan J. Adam</span>, <span class="highwire-citation-author" data-delta="1">Mark R. Paterson</span>, <span class="highwire-citation-author" data-delta="2">Lukus Wardecke</span>, <span class="highwire-citation-author" data-delta="3">Brian R. Hoffmann</span> and <span class="highwire-citation-author" data-delta="4">Alison J. Kriegel</span></span> </div> <div class="highwire-cite-metadata"> <span class="highwire-cite-metadata-journal highwire-cite-metadata">Kidney360 </span> <span class="highwire-cite-metadata-date highwire-cite-metadata">August 2020, </span> <span class="highwire-cite-metadata-pages highwire-cite-metadata">10.34067/KID.0001212020; </span> <span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.34067/KID.0001212020 </span> </div> </div> <div id="hw-article-author-popups-node38562--21478237114" style="display: none;"> <div class="author-tooltip-0"> <div class="author-tooltip-name">Ryan J. Adam </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">1</span>Medical College of Wisconsin, United States</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-1"> <div class="author-tooltip-name">Mark R. Paterson </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">2</span>Life and Earth Sciences, Medical College of Wisconsin, United States</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-2"> <div class="author-tooltip-name">Lukus Wardecke </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">1</span>Medical College of Wisconsin, United States</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-3"> <div class="author-tooltip-name">Brian R. Hoffmann </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">3</span>Biomedical Engineering, Medical College of Wisconsin, United States</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link">Search for this author on this site</li> <li class="author-orcid-link last">ORCID record for Brian R. Hoffmann</li> </ul> </div> <div class="author-tooltip-4"> <div class="author-tooltip-name">Alison J. Kriegel </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">4</span>Physiology, Medical College of Wisconsin, United States</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link">Search for this author on this site</li> <li class="author-corresp-email-link last"> <span>For correspondence: akriegel@mcw.edu</span> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="panel-row-wrapper clearfix"> <div class="main-content-wrapper grid-17 suffix-1 alpha"> <div class="panel-panel panel-region-content"> <div class="inside"> <div class="panel-pane pane-highwire-markup border-top-hairline"> <div class="pane-content"> <div class="highwire-markup"> <div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="content-block-markup"> <div> <span class="highwire-journal-article-marker-start"/> <div class="auto-clean"> <span style="font-family: Verdana,Arial,Helvetica,sans-serif; 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