Compound ID,Structure,"Binding affinity to AKT1 (Kd, nM)","Binding affinity to AKT2 (Kd, nM)","Binding affinity to AKT3 (Kd, nM)",Activity in reducing AKT protein levels in BT-474 cells  at 1 uM by western blotting,Activity in reducing AKT protein levels in PC-3 cells  at 1 uM by western blotting,DC50 in BT-474 (nM),GI50 in BT474 Cells (uM),GI50 in PC3 Cells (uM),GI50 in MDA-MB-468 Cells (uM)
3,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined,Not determined
4,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined,Not determined
5,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined,Not determined
6,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
7,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
8,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
9,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
10,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
11,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
12,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
13,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCNC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,4 ± 3.6,140 ± 4.5,8.1 ± 2.7,Active,Not determined,78 ± 64,1.3 ± 0.3,9.2 ± 1.3,3.8 ± 1.2
14,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
15,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
16,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
17,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
18,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCOCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
19,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined,Not determined
20,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined,Not determined
21,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
22,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
23,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
24,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
25,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,1.3 ± 1.6,77 ± 6.9,6.5 ± 3.1,Active,Not determined,32 ± 18,0.7 ± 0.2,7.4 ± 2.2,5.7 ± 2.4
26,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCNC(CCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined,Not determined
27,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCCC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
28,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCNC4=CC=CC5=C4CN(C6C(NC(CC6)=O)=O)C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined,Not determined
29,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCOC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined,Not determined
31,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
32,O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCOCCNC(CCCNCCCOC4=CN=C(C#CC(C)(C)O)C5=C4N(CC)C(C6=NON=C6N)=N5)=O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
33,O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)COCCOCCNC(CCCNCCCOC4=CN=C(C#CC(C)(C)O)C5=C4N(CC)C(C6=NON=C6N)=N5)=O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
34,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
35,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
36,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
37,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
38,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
39,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
40,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
41,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
42,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
43,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
44,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
45,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
46,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
47,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
48,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
49,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
50,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
51,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
52,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
53,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCOCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
54,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
55,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
56,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined,Not determined
57,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
58,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
59,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
60,CCN1C(C2=NON=C2N)=NC3=C1C(OCCCNCCCC(NCCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)=CN=C3C#CC(C)(C)O,Not determined,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined,Not determined
61,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCNC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@H](O)C4)=O)=O)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,1.9 ± 2.7,84 ± 3.1,4.2 ± 2.6,Inactive,Not determined,Not determined,3.1 ± 0.4,Not determined,Not determined
62,C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C([C@H](CNCCC(NCCCCCCCCNC4=C(C(N(C5C(N(C)C(CC5)=O)=O)C6=O)=O)C6=CC=C4)=O)C7=CC=C(Cl)C=C7)=O)CC3)=C21,1.8 ± 2.6,74 ± 4.2,12 ± 2.4,Inactive,Not determined,Not determined,3.3 ± 0.8,Not determined,Not determined