TFs removed in iteration: 1 Name, P-value, Enrichment KEGG_LONG_TERM_DEPRESSION, 0.0100918943239, 4.06448814344 KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES, 0.238789979004, 3.91550818659 KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES, 0.253485835407, 3.63568559954 KEGG_BASAL_CELL_CARCINOMA, 0.0620497055311, 3.48029692082 KEGG_OLFACTORY_TRANSDUCTION, 2.218006169e-06, 3.31836965555 KEGG_ETHER_LIPID_METABOLISM, 0.132847689277, 3.28824560265 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION, 0.000255015207324, 3.06354525932 KEGG_ALPHA_LINOLENIC_ACID_METABOLISM, 0.309491598645, 2.82730923695 KEGG_CALCIUM_SIGNALING_PATHWAY, 0.00763977640892, 2.75444606414 KEGG_PYRUVATE_METABOLISM, 0.180234935007, 2.68177485968 TFs removed in iteration: 2 Name, P-value, Enrichment KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES, 0.0290060346313, 8.50100603622 KEGG_BASAL_CELL_CARCINOMA, 0.0126978436106, 4.75809255344 KEGG_SULFUR_METABOLISM, 0.223805411549, 4.24196787149 KEGG_GAP_JUNCTION, 0.00716508529018, 3.75204076584 KEGG_MELANOGENESIS, 0.00797285773145, 3.66241669081 KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES, 0.253485835407, 3.63568559954 KEGG_STEROID_BIOSYNTHESIS, 0.28203351535, 3.18097389558 KEGG_RENIN_ANGIOTENSIN_SYSTEM, 0.28203351535, 3.18097389558 KEGG_HEDGEHOG_SIGNALING_PATHWAY, 0.0789277716279, 3.12454739961 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION, 0.000255015207324, 3.06354525932 TFs removed in iteration: 3 Name, P-value, Enrichment KEGG_BASAL_CELL_CARCINOMA, 0.00206299394676, 6.1017929439 KEGG_LINOLEIC_ACID_METABOLISM, 0.107297092932, 3.77598926895 KEGG_ABC_TRANSPORTERS, 0.0528342511665, 3.73539535799 KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS, 0.267898532463, 3.39317269076 KEGG_HEDGEHOG_SIGNALING_PATHWAY, 0.0789277716279, 3.12454739961 KEGG_MELANOGENESIS, 0.0302766721217, 3.00988330555 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 0.0899105993357, 2.94393610422 KEGG_ALPHA_LINOLENIC_ACID_METABOLISM, 0.309491598645, 2.82730923695 KEGG_AXON_GUIDANCE, 0.0333557973805, 2.60363736377 KEGG_WNT_SIGNALING_PATHWAY, 0.0431353802188, 2.43755433208 TFs removed in iteration: 4 Name, P-value, Enrichment KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES, 0.0290060346313, 8.50100603622 KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS, 0.0372953795856, 7.28600172463 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 0.000652003852332, 6.28712174525 KEGG_BASAL_CELL_CARCINOMA, 0.00206299394676, 6.1017929439 KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES, 0.0891358200979, 4.24849094567 KEGG_SULFUR_METABOLISM, 0.223805411549, 4.24196787149 KEGG_LINOLEIC_ACID_METABOLISM, 0.107297092932, 3.77598926895 KEGG_O_GLYCAN_BIOSYNTHESIS, 0.107297092932, 3.77598926895 KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES, 0.253485835407, 3.63568559954 KEGG_STEROID_BIOSYNTHESIS, 0.28203351535, 3.18097389558 TFs removed in iteration: 5 Name, P-value, Enrichment KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES, 0.0290060346313, 8.50100603622 KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE, 0.0330479893769, 7.84677294536 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM, 0.00359741698806, 7.05900383142 KEGG_BASAL_CELL_CARCINOMA, 0.00206299394676, 6.1017929439 KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM, 0.17706228367, 5.65662650602 KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION, 0.0720247911214, 4.85599310147 KEGG_NITROGEN_METABOLISM, 0.0720247911214, 4.85599310147 KEGG_MELANOGENESIS, 0.00179794168946, 4.33325986874 KEGG_ARGININE_AND_PROLINE_METABOLISM, 0.0190565034987, 4.17447948877 KEGG_ACUTE_MYELOID_LEUKEMIA, 0.0443392557528, 4.03077249576 TFs removed in iteration: 6 Name, P-value, Enrichment KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS, 0.0372953795856, 7.28600172463 KEGG_STARCH_AND_SUCROSE_METABOLISM, 0.017883345478, 4.26161616162 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 0.0215428716443, 4.01045751634 KEGG_LONG_TERM_POTENTIATION, 0.0107123372222, 4.00082236842 KEGG_BASAL_CELL_CARCINOMA, 0.0620497055311, 3.48029692082 KEGG_PHENYLALANINE_METABOLISM, 0.28203351535, 3.18097389558 KEGG_HEDGEHOG_SIGNALING_PATHWAY, 0.0789277716279, 3.12454739961 KEGG_WNT_SIGNALING_PATHWAY, 0.0143038064429, 2.87250406504 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION, 0.0768233552971, 2.58616545199 KEGG_P53_SIGNALING_PATHWAY, 0.130610894458, 2.46813215401 TFs removed in iteration: 7 Name, P-value, Enrichment KEGG_STEROID_HORMONE_BIOSYNTHESIS, 9.97955256307e-06, 8.77583741388 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450, 9.20344559311e-07, 8.62372188139 KEGG_RETINOL_METABOLISM, 3.11723808375e-05, 7.36281640966 KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS, 0.0372953795856, 7.28600172463 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM, 0.00359741698806, 7.05900383142 KEGG_FATTY_ACID_METABOLISM, 0.00123785838651, 6.92772732246 KEGG_DRUG_METABOLISM_CYTOCHROME_P450, 7.36807988187e-05, 6.44042769857 KEGG_BASAL_CELL_CARCINOMA, 0.00206299394676, 6.1017929439 KEGG_ARACHIDONIC_ACID_METABOLISM, 0.000867155040544, 5.9237010454 KEGG_LINOLEIC_ACID_METABOLISM, 0.0179862200259, 5.89392059553 TFs removed in iteration: 8 Name, P-value, Enrichment KEGG_STEROID_HORMONE_BIOSYNTHESIS, 9.97605973737e-07, 10.1084294587 KEGG_SULFUR_METABOLISM, 0.0251792066357, 9.27419059813 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450, 9.20344559311e-07, 8.62372188139 KEGG_ASTHMA, 0.0025213882469, 7.87443667444 KEGG_DRUG_METABOLISM_OTHER_ENZYMES, 0.00296667487225, 5.57032212639 KEGG_BASAL_CELL_CARCINOMA, 0.0126978436106, 4.75809255344 KEGG_DRUG_METABOLISM_CYTOCHROME_P450, 0.00267024043436, 4.66457680251 KEGG_ASCORBATE_AND_ALDARATE_METABOLISM, 0.0833063684969, 4.43338290613 KEGG_RETINOL_METABOLISM, 0.0078562035998, 4.34073286214 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION, 0.0443392557528, 4.03077249576 TFs removed in iteration: 9 Name, P-value, Enrichment KEGG_CIRCADIAN_RHYTHM_MAMMAL, 0.127510221655, 8.4859437751 KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM, 0.17706228367, 5.65662650602 KEGG_BASAL_CELL_CARCINOMA, 0.0126978436106, 4.75809255344 KEGG_SMALL_CELL_LUNG_CANCER, 0.0127289023808, 3.82122786875 KEGG_ENDOMETRIAL_CANCER, 0.0528342511665, 3.73539535799 KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE, 0.253485835407, 3.63568559954 KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS, 0.267898532463, 3.39317269076 KEGG_OTHER_GLYCAN_DEGRADATION, 0.267898532463, 3.39317269076 KEGG_GLYCEROLIPID_METABOLISM, 0.0685791173821, 3.32871669004 KEGG_MTOR_SIGNALING_PATHWAY, 0.0719559939887, 3.25776424159 TFs removed in iteration: 10 Name, P-value, Enrichment KEGG_CIRCADIAN_RHYTHM_MAMMAL, 0.127510221655, 8.4859437751 KEGG_SMALL_CELL_LUNG_CANCER, 0.000476734260255, 5.53717948718 KEGG_TGF_BETA_SIGNALING_PATHWAY, 0.0142071345546, 3.71017426509 KEGG_NON_SMALL_CELL_LUNG_CANCER, 0.0558274016831, 3.64631336406 KEGG_BASAL_CELL_CARCINOMA, 0.0620497055311, 3.48029692082 KEGG_OTHER_GLYCAN_DEGRADATION, 0.267898532463, 3.39317269076 KEGG_THYROID_CANCER, 0.295896124682, 2.99373966454 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 0.0899105993357, 2.94393610422 KEGG_BLADDER_CANCER, 0.159590474044, 2.91198620293 KEGG_GLIOMA, 0.11362824757, 2.63876529477 TFs removed in iteration: 11 Name, P-value, Enrichment KEGG_CIRCADIAN_RHYTHM_MAMMAL, 0.127510221655, 8.4859437751 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 8.70046128301e-05, 7.50330284553 KEGG_BASAL_CELL_CARCINOMA, 0.0126978436106, 4.75809255344 KEGG_ASCORBATE_AND_ALDARATE_METABOLISM, 0.0833063684969, 4.43338290613 KEGG_DRUG_METABOLISM_OTHER_ENZYMES, 0.0167562527382, 4.35246077799 KEGG_SULFUR_METABOLISM, 0.223805411549, 4.24196787149 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION, 0.0443392557528, 4.03077249576 KEGG_LONG_TERM_POTENTIATION, 0.0107123372222, 4.00082236842 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450, 0.0113583464477, 3.93911554033 KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS, 0.101137722392, 3.92137440025 TFs removed in iteration: 12 Name, P-value, Enrichment KEGG_ASTHMA, 2.00622600718e-05, 12.8488843813 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY, 1.92757182932e-05, 7.93044023187 KEGG_LEISHMANIA_INFECTION, 3.49540043885e-05, 7.23335834495 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS, 0.000109656963557, 7.20260162602 KEGG_PHENYLALANINE_METABOLISM, 0.0417388065604, 6.8 KEGG_HISTIDINE_METABOLISM, 0.0163550905394, 6.12991935484 KEGG_DORSO_VENTRAL_AXIS_FORMATION, 0.0511775932603, 5.99952657119 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450, 0.000400976536541, 5.71341463415 KEGG_HEMATOPOIETIC_CELL_LINEAGE, 0.000279679458323, 5.21446801928 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 0.00412613156507, 5.12388663968 TFs removed in iteration: 13 Name, P-value, Enrichment KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS, 0.0372953795856, 7.28600172463 KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM, 0.17706228367, 5.65662650602 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 0.00412613156507, 5.12388663968 KEGG_ASCORBATE_AND_ALDARATE_METABOLISM, 0.0833063684969, 4.43338290613 KEGG_TIGHT_JUNCTION, 0.000194683114262, 4.37489168486 KEGG_DRUG_METABOLISM_OTHER_ENZYMES, 0.0167562527382, 4.35246077799 KEGG_STARCH_AND_SUCROSE_METABOLISM, 0.017883345478, 4.26161616162 KEGG_SULFUR_METABOLISM, 0.223805411549, 4.24196787149 KEGG_ECM_RECEPTOR_INTERACTION, 0.00572952751265, 3.94507723514 KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS, 0.101137722392, 3.92137440025 TFs removed in iteration: 14 Name, P-value, Enrichment KEGG_ASTHMA, 4.85519600447e-12, 30.0661130285 KEGG_ALLOGRAFT_REJECTION, 6.72662778332e-11, 21.9653215637 KEGG_PRIMARY_IMMUNODEFICIENCY, 1.27198869433e-07, 17.2016293279 KEGG_GRAFT_VERSUS_HOST_DISEASE, 4.28951344801e-09, 16.7102051587 KEGG_AUTOIMMUNE_THYROID_DISEASE, 2.39340274968e-10, 15.5987679671 KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION, 1.46790639356e-09, 15.428389455 KEGG_TYPE_I_DIABETES_MELLITUS, 1.08633356348e-07, 13.6825930372 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS, 1.02502386722e-08, 12.4053813257 KEGG_VIRAL_MYOCARDITIS, 9.20344559311e-07, 8.62372188139 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY, 7.02864675764e-09, 8.58406306853 TFs removed in iteration: 15 Name, P-value, Enrichment KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM, 0.0025213882469, 7.87443667444 KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS, 0.0372953795856, 7.28600172463 KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM, 0.0372953795856, 7.28600172463 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450, 6.01015600543e-05, 6.64870902043 KEGG_STEROID_HORMONE_BIOSYNTHESIS, 0.000652003852332, 6.28712174525 KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM, 0.17706228367, 5.65662650602 KEGG_DRUG_METABOLISM_CYTOCHROME_P450, 0.000476734260255, 5.53717948718 KEGG_FATTY_ACID_METABOLISM, 0.00858988503036, 5.38522062733 KEGG_RETINOL_METABOLISM, 0.00145777493464, 5.30964538015 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM, 0.025383998885, 5.10725806452