# Table S11: GO terms enriched in the genes with highest DM scores in individual 18 (genotype NA18523) in iPSCs. Enrichment performed using GORILLA. N - total number of genes, B - total number of genes associated with a specific GO term, n - number of genes in the top of the user's input list, b - number of genes in the intersection. GO Term Description P-value FDR q-value Enrichment N B n b Genes GO:0006396 RNA processing 2.37E-08 2.92E-04 1.91 7204 435 728 84 "[WDR4 - wd repeat domain 4, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, BCAS2 - breast carcinoma amplified sequence 2, TSN - translin, DBR1 - debranching rna lariats 1, KRR1 - krr1, small subunit (ssu) processome component, homolog (yeast), MAGOH - mago-nashi homolog, proliferation-associated (drosophila), CDC5L - cell division cycle 5-like, PAPD5 - pap associated domain containing 5, SYF2 - syf2 pre-mrna-splicing factor, HELQ - helicase, polq-like, RPP25 - ribonuclease p/mrp 25kda subunit, HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), FAM207A - family with sequence similarity 207, member a, SF3A2 - splicing factor 3a, subunit 2, 66kda, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, TFB2M - transcription factor b2, mitochondrial, PCBP1 - poly(rc) binding protein 1, AGO1 - argonaute risc catalytic component 1, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), PUSL1 - pseudouridylate synthase-like 1, UBL5 - ubiquitin-like 5, RBM19 - rna binding motif protein 19, UTP3 - utp3, small subunit (ssu) processome component, homolog (s. cerevisiae), TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), RPF1 - ribosome production factor 1 homolog (s. cerevisiae), SLBP - stem-loop binding protein, TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), ALYREF - aly/ref export factor, RNPS1 - rna binding protein s1, serine-rich domain, TP53RK - tp53 regulating kinase, AURKAIP1 - aurora kinase a interacting protein 1, DCAF13 - ddb1 and cul4 associated factor 13, DDX56 - dead (asp-glu-ala-asp) box helicase 56, SNRPB2 - small nuclear ribonucleoprotein polypeptide b, SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), BMS1 - bms1 ribosome biogenesis factor, PPIL1 - peptidylprolyl isomerase (cyclophilin)-like 1, SNRPD1 - small nuclear ribonucleoprotein d1 polypeptide 16kda, SF3B14 - splicing factor 3b, 14 kda subunit, SRRM4 - serine/arginine repetitive matrix 4, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, BUD13 - bud13 homolog (s. cerevisiae), SNORD35B - small nucleolar rna, c/d box 35b, THG1L - trna-histidine guanylyltransferase 1-like (s. cerevisiae), RIOK1 - rio kinase 1, RRP1 - ribosomal rna processing 1, SNORA52 - small nucleolar rna, h/aca box 52, SNORA76 - small nucleolar rna, h/aca box 76, DDX21 - dead (asp-glu-ala-asp) box helicase 21, XRN2 - 5'-3' exoribonuclease 2, RPS15 - ribosomal protein s15, PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3, TGS1 - trimethylguanosine synthase 1, CTU1 - cytosolic thiouridylase subunit 1, SF3B5 - splicing factor 3b, subunit 5, 10kda, DHX37 - deah (asp-glu-ala-his) box polypeptide 37, TXNL4B - thioredoxin-like 4b, NHP2 - nhp2 ribonucleoprotein, PHF5A - phd finger protein 5a, SNIP1 - smad nuclear interacting protein 1, SLU7 - slu7 splicing factor homolog (s. cerevisiae), IMP4 - imp4, u3 small nucleolar ribonucleoprotein, homolog (yeast), PHRF1 - phd and ring finger domains 1, KIAA0391 - kiaa0391, BYSL - bystin-like, C1QBP - complement component 1, q subcomponent binding protein, SRSF1 - serine/arginine-rich splicing factor 1, U2AF2 - u2 small nuclear rna auxiliary factor 2, TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), LIN28B - lin-28 homolog b (c. elegans), LCMT2 - leucine carboxyl methyltransferase 2, DGCR14 - digeorge syndrome critical region gene 14, SNORA29 - small nucleolar rna, h/aca box 29, EXOSC4 - exosome component 4, NOP10 - nop10 ribonucleoprotein, SNORD73A - small nucleolar rna, c/d box 73a, MOCS3 - molybdenum cofactor synthesis 3, TRMT10C - trna methyltransferase 10 homolog c (s. cerevisiae), POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, YBEY - ybey metallopeptidase (putative), PDE12 - phosphodiesterase 12, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2]" GO:0000377 "RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" 5.54E-07 3.41E-03 2.57 7204 128 811 37 "[SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), SNRPB2 - small nuclear ribonucleoprotein polypeptide b, PPIL1 - peptidylprolyl isomerase (cyclophilin)-like 1, SF3B14 - splicing factor 3b, 14 kda subunit, SNRPD1 - small nuclear ribonucleoprotein d1 polypeptide 16kda, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, BCAS2 - breast carcinoma amplified sequence 2, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), DBR1 - debranching rna lariats 1, CDC5L - cell division cycle 5-like, SYF2 - syf2 pre-mrna-splicing factor, BUD13 - bud13 homolog (s. cerevisiae), HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), SF3A2 - splicing factor 3a, subunit 2, 66kda, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, PCBP1 - poly(rc) binding protein 1, PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3, SF3B5 - splicing factor 3b, subunit 5, 10kda, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), TXNL4B - thioredoxin-like 4b, UBL5 - ubiquitin-like 5, SNIP1 - smad nuclear interacting protein 1, PHF5A - phd finger protein 5a, SLU7 - slu7 splicing factor homolog (s. cerevisiae), RBM19 - rna binding motif protein 19, POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, U2AF2 - u2 small nuclear rna auxiliary factor 2, SRSF1 - serine/arginine-rich splicing factor 1, MFAP1 - microfibrillar-associated protein 1, ALYREF - aly/ref export factor, DGCR14 - digeorge syndrome critical region gene 14, RNPS1 - rna binding protein s1, serine-rich domain, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2, SNRNP40 - small nuclear ribonucleoprotein 40kda (u5)]" GO:0000398 "mRNA splicing, via spliceosome" 5.54E-07 2.27E-03 2.57 7204 128 811 37 "[SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), SNRPB2 - small nuclear ribonucleoprotein polypeptide b, PPIL1 - peptidylprolyl isomerase (cyclophilin)-like 1, SF3B14 - splicing factor 3b, 14 kda subunit, SNRPD1 - small nuclear ribonucleoprotein d1 polypeptide 16kda, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, BCAS2 - breast carcinoma amplified sequence 2, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), DBR1 - debranching rna lariats 1, CDC5L - cell division cycle 5-like, SYF2 - syf2 pre-mrna-splicing factor, BUD13 - bud13 homolog (s. cerevisiae), HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), SF3A2 - splicing factor 3a, subunit 2, 66kda, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, PCBP1 - poly(rc) binding protein 1, PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3, SF3B5 - splicing factor 3b, subunit 5, 10kda, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), TXNL4B - thioredoxin-like 4b, UBL5 - ubiquitin-like 5, PHF5A - phd finger protein 5a, SNIP1 - smad nuclear interacting protein 1, SLU7 - slu7 splicing factor homolog (s. cerevisiae), RBM19 - rna binding motif protein 19, POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, SRSF1 - serine/arginine-rich splicing factor 1, U2AF2 - u2 small nuclear rna auxiliary factor 2, MFAP1 - microfibrillar-associated protein 1, ALYREF - aly/ref export factor, DGCR14 - digeorge syndrome critical region gene 14, RNPS1 - rna binding protein s1, serine-rich domain, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2, SNRNP40 - small nuclear ribonucleoprotein 40kda (u5)]" GO:0000375 "RNA splicing, via transesterification reactions" 8.70E-07 2.68E-03 2.53 7204 130 811 37 "[SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), SNRPB2 - small nuclear ribonucleoprotein polypeptide b, PPIL1 - peptidylprolyl isomerase (cyclophilin)-like 1, SF3B14 - splicing factor 3b, 14 kda subunit, SNRPD1 - small nuclear ribonucleoprotein d1 polypeptide 16kda, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, BCAS2 - breast carcinoma amplified sequence 2, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), DBR1 - debranching rna lariats 1, CDC5L - cell division cycle 5-like, SYF2 - syf2 pre-mrna-splicing factor, BUD13 - bud13 homolog (s. cerevisiae), HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), SF3A2 - splicing factor 3a, subunit 2, 66kda, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, PCBP1 - poly(rc) binding protein 1, PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3, SF3B5 - splicing factor 3b, subunit 5, 10kda, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), TXNL4B - thioredoxin-like 4b, UBL5 - ubiquitin-like 5, PHF5A - phd finger protein 5a, SNIP1 - smad nuclear interacting protein 1, SLU7 - slu7 splicing factor homolog (s. cerevisiae), RBM19 - rna binding motif protein 19, POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, SRSF1 - serine/arginine-rich splicing factor 1, U2AF2 - u2 small nuclear rna auxiliary factor 2, MFAP1 - microfibrillar-associated protein 1, ALYREF - aly/ref export factor, DGCR14 - digeorge syndrome critical region gene 14, RNPS1 - rna binding protein s1, serine-rich domain, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2, SNRNP40 - small nuclear ribonucleoprotein 40kda (u5)]" GO:0016070 RNA metabolic process 1.92E-06 4.73E-03 1.65 7204 735 600 101 "[BCAS2 - breast carcinoma amplified sequence 2, TSN - translin, CDC5L - cell division cycle 5-like, SYF2 - syf2 pre-mrna-splicing factor, HELQ - helicase, polq-like, HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, SF3A2 - splicing factor 3a, subunit 2, 66kda, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, PCBP1 - poly(rc) binding protein 1, ENDOG - endonuclease g, GTF2A2 - general transcription factor iia, 2, 12kda, NELFB - negative elongation factor complex member b, SP1 - sp1 transcription factor, RBM19 - rna binding motif protein 19, TTF1 - transcription termination factor, rna polymerase i, ALYREF - aly/ref export factor, PABPC3 - poly(a) binding protein, cytoplasmic 3, RNPS1 - rna binding protein s1, serine-rich domain, TP53RK - tp53 regulating kinase, LDB1 - lim domain binding 1, DCAF13 - ddb1 and cul4 associated factor 13, USPL1 - ubiquitin specific peptidase like 1, SNRPB2 - small nuclear ribonucleoprotein polypeptide b, BMS1 - bms1 ribosome biogenesis factor, TAF7 - taf7 rna polymerase ii, tata box binding protein (tbp)-associated factor, 55kda, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, SRRM4 - serine/arginine repetitive matrix 4, SUPT16H - suppressor of ty 16 homolog (s. cerevisiae), NABP2 - nucleic acid binding protein 2, RRP1 - ribosomal rna processing 1, DDX21 - dead (asp-glu-ala-asp) box helicase 21, PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3, CTU1 - cytosolic thiouridylase subunit 1, SF3B5 - splicing factor 3b, subunit 5, 10kda, SLU7 - slu7 splicing factor homolog (s. cerevisiae), IMP4 - imp4, u3 small nucleolar ribonucleoprotein, homolog (yeast), POLRMT - polymerase (rna) mitochondrial (dna directed), BYSL - bystin-like, C1QBP - complement component 1, q subcomponent binding protein, LIN28B - lin-28 homolog b (c. elegans), DGCR14 - digeorge syndrome critical region gene 14, LCMT2 - leucine carboxyl methyltransferase 2, SNORA29 - small nucleolar rna, h/aca box 29, NOP10 - nop10 ribonucleoprotein, SNORD73A - small nucleolar rna, c/d box 73a, MOCS3 - molybdenum cofactor synthesis 3, TCEANC2 - transcription elongation factor a (sii) n-terminal and central domain containing 2, YBEY - ybey metallopeptidase (putative), WDR4 - wd repeat domain 4, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), DBR1 - debranching rna lariats 1, TAF5L - taf5-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), FAM207A - family with sequence similarity 207, member a, TFB2M - transcription factor b2, mitochondrial, AGO1 - argonaute risc catalytic component 1, UBL5 - ubiquitin-like 5, PUSL1 - pseudouridylate synthase-like 1, TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), UTP3 - utp3, small subunit (ssu) processome component, homolog (s. cerevisiae), RPF1 - ribosome production factor 1 homolog (s. cerevisiae), TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), RPL38 - ribosomal protein l38, RPL41 - ribosomal protein l41, AURKAIP1 - aurora kinase a interacting protein 1, CBLL1 - cbl proto-oncogene-like 1, e3 ubiquitin protein ligase, DDX56 - dead (asp-glu-ala-asp) box helicase 56, RPL28 - ribosomal protein l28, SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), PPIL1 - peptidylprolyl isomerase (cyclophilin)-like 1, SF3B14 - splicing factor 3b, 14 kda subunit, UBA52 - ubiquitin a-52 residue ribosomal protein fusion product 1, JUN - jun proto-oncogene, BUD13 - bud13 homolog (s. cerevisiae), RIOK1 - rio kinase 1, THG1L - trna-histidine guanylyltransferase 1-like (s. cerevisiae), RPS18 - ribosomal protein s18, NFIL3 - nuclear factor, interleukin 3 regulated, C10orf2 - chromosome 10 open reading frame 2, XRN2 - 5'-3' exoribonuclease 2, SNORA52 - small nucleolar rna, h/aca box 52, RPS15 - ribosomal protein s15, TGS1 - trimethylguanosine synthase 1, DHX37 - deah (asp-glu-ala-his) box polypeptide 37, TXNL4B - thioredoxin-like 4b, SNIP1 - smad nuclear interacting protein 1, PHRF1 - phd and ring finger domains 1, SMARCA5 - swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5, KIAA0391 - kiaa0391, U2AF2 - u2 small nuclear rna auxiliary factor 2, SRSF1 - serine/arginine-rich splicing factor 1, MTERF - mitochondrial transcription termination factor, ALKBH3 - alkb, alkylation repair homolog 3 (e. coli), TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), MEPCE - methylphosphate capping enzyme, EXOSC4 - exosome component 4, BRF2 - brf2, rna polymerase iii transcription initiation factor 50 kda subunit, TRMT10C - trna methyltransferase 10 homolog c (s. cerevisiae), GTF3C4 - general transcription factor iiic, polypeptide 4, 90kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2]" GO:0008380 RNA splicing 1.35E-05 2.77E-02 2.34 7204 165 635 34 "[SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), SNRPB2 - small nuclear ribonucleoprotein polypeptide b, PPIL1 - peptidylprolyl isomerase (cyclophilin)-like 1, SF3B14 - splicing factor 3b, 14 kda subunit, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, SRRM4 - serine/arginine repetitive matrix 4, BCAS2 - breast carcinoma amplified sequence 2, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), DBR1 - debranching rna lariats 1, CDC5L - cell division cycle 5-like, SYF2 - syf2 pre-mrna-splicing factor, BUD13 - bud13 homolog (s. cerevisiae), HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), SF3A2 - splicing factor 3a, subunit 2, 66kda, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, PCBP1 - poly(rc) binding protein 1, PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3, SF3B5 - splicing factor 3b, subunit 5, 10kda, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), TXNL4B - thioredoxin-like 4b, UBL5 - ubiquitin-like 5, SNIP1 - smad nuclear interacting protein 1, SLU7 - slu7 splicing factor homolog (s. cerevisiae), RBM19 - rna binding motif protein 19, U2AF2 - u2 small nuclear rna auxiliary factor 2, SRSF1 - serine/arginine-rich splicing factor 1, C1QBP - complement component 1, q subcomponent binding protein, ALYREF - aly/ref export factor, DGCR14 - digeorge syndrome critical region gene 14, RNPS1 - rna binding protein s1, serine-rich domain, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2]" GO:0006397 mRNA processing 1.57E-05 2.77E-02 2.1 7204 198 728 42 "[SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), SNRPB2 - small nuclear ribonucleoprotein polypeptide b, PPIL1 - peptidylprolyl isomerase (cyclophilin)-like 1, SF3B14 - splicing factor 3b, 14 kda subunit, SNRPD1 - small nuclear ribonucleoprotein d1 polypeptide 16kda, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, SRRM4 - serine/arginine repetitive matrix 4, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, BCAS2 - breast carcinoma amplified sequence 2, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), DBR1 - debranching rna lariats 1, CDC5L - cell division cycle 5-like, PAPD5 - pap associated domain containing 5, SYF2 - syf2 pre-mrna-splicing factor, HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, BUD13 - bud13 homolog (s. cerevisiae), PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), SF3A2 - splicing factor 3a, subunit 2, 66kda, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, XRN2 - 5'-3' exoribonuclease 2, PCBP1 - poly(rc) binding protein 1, PPIL3 - peptidylprolyl isomerase (cyclophilin)-like 3, SF3B5 - splicing factor 3b, subunit 5, 10kda, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), UBL5 - ubiquitin-like 5, TXNL4B - thioredoxin-like 4b, SNIP1 - smad nuclear interacting protein 1, PHF5A - phd finger protein 5a, SLU7 - slu7 splicing factor homolog (s. cerevisiae), PHRF1 - phd and ring finger domains 1, RBM19 - rna binding motif protein 19, SRSF1 - serine/arginine-rich splicing factor 1, U2AF2 - u2 small nuclear rna auxiliary factor 2, C1QBP - complement component 1, q subcomponent binding protein, SLBP - stem-loop binding protein, DGCR14 - digeorge syndrome critical region gene 14, ALYREF - aly/ref export factor, RNPS1 - rna binding protein s1, serine-rich domain, AURKAIP1 - aurora kinase a interacting protein 1, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, PDE12 - phosphodiesterase 12, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2]" GO:0016071 mRNA metabolic process 5.66E-05 8.72E-02 2.81 7204 296 199 23 "[SMU1 - smu-1 suppressor of mec-8 and unc-52 homolog (c. elegans), SNRPB2 - small nuclear ribonucleoprotein polypeptide b, PHRF1 - phd and ring finger domains 1, SF3B14 - splicing factor 3b, 14 kda subunit, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), U2AF2 - u2 small nuclear rna auxiliary factor 2, SRSF1 - serine/arginine-rich splicing factor 1, SYF2 - syf2 pre-mrna-splicing factor, HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), ALYREF - aly/ref export factor, DGCR14 - digeorge syndrome critical region gene 14, GTF2F1 - general transcription factor iif, polypeptide 1, 74kda, EXOSC4 - exosome component 4, RPL41 - ribosomal protein l41, XRN2 - 5'-3' exoribonuclease 2, PCBP1 - poly(rc) binding protein 1, AURKAIP1 - aurora kinase a interacting protein 1, TRMT10C - trna methyltransferase 10 homolog c (s. cerevisiae), CD2BP2 - cd2 (cytoplasmic tail) binding protein 2, RPL28 - ribosomal protein l28]" GO:0046039 GTP metabolic process 1.09E-04 1.49E-01 277.08 7204 13 4 2 "[MOCS3 - molybdenum cofactor synthesis 3, GNAI3 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 3]" GO:0051301 cell division 1.38E-04 1.69E-01 37.92 7204 190 3 3 "[SSSCA1 - sjogren syndrome/scleroderma autoantigen 1, KLHL18 - kelch-like family member 18, GNAI3 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 3]" GO:0007049 cell cycle 1.61E-04 1.81E-01 36.57 7204 197 3 3 "[SSSCA1 - sjogren syndrome/scleroderma autoantigen 1, KLHL18 - kelch-like family member 18, GNAI3 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 3]" GO:1901068 guanosine-containing compound metabolic process 1.66E-04 1.70E-01 225.12 7204 16 4 2 "[MOCS3 - molybdenum cofactor synthesis 3, GNAI3 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 3]" GO:0009451 RNA modification 1.99E-04 1.88E-01 3.13 7204 74 529 17 "[WDR4 - wd repeat domain 4, KIAA0391 - kiaa0391, TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), ALKBH3 - alkb, alkylation repair homolog 3 (e. coli), TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), THG1L - trna-histidine guanylyltransferase 1-like (s. cerevisiae), LCMT2 - leucine carboxyl methyltransferase 2, MEPCE - methylphosphate capping enzyme, TFB2M - transcription factor b2, mitochondrial, NOP10 - nop10 ribonucleoprotein, TRMT10C - trna methyltransferase 10 homolog c (s. cerevisiae), MOCS3 - molybdenum cofactor synthesis 3, CBLL1 - cbl proto-oncogene-like 1, e3 ubiquitin protein ligase, CTU1 - cytosolic thiouridylase subunit 1, TGS1 - trimethylguanosine synthase 1, PUSL1 - pseudouridylate synthase-like 1]" GO:0046128 purine ribonucleoside metabolic process 3.22E-04 2.83E-01 171.52 7204 21 4 2 "[MOCS3 - molybdenum cofactor synthesis 3, GNAI3 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 3]" GO:0042278 purine nucleoside metabolic process 3.85E-04 3.16E-01 163.73 7204 22 4 2 "[MOCS3 - molybdenum cofactor synthesis 3, GNAI3 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 3]" GO:0034470 ncRNA processing 5.04E-04 3.88E-01 2.04 7204 206 549 32 "[WDR4 - wd repeat domain 4, BMS1 - bms1 ribosome biogenesis factor, HELQ - helicase, polq-like, RIOK1 - rio kinase 1, THG1L - trna-histidine guanylyltransferase 1-like (s. cerevisiae), FAM207A - family with sequence similarity 207, member a, TFB2M - transcription factor b2, mitochondrial, RRP1 - ribosomal rna processing 1, XRN2 - 5'-3' exoribonuclease 2, DDX21 - dead (asp-glu-ala-asp) box helicase 21, CTU1 - cytosolic thiouridylase subunit 1, DHX37 - deah (asp-glu-ala-his) box polypeptide 37, AGO1 - argonaute risc catalytic component 1, PUSL1 - pseudouridylate synthase-like 1, IMP4 - imp4, u3 small nucleolar ribonucleoprotein, homolog (yeast), KIAA0391 - kiaa0391, BYSL - bystin-like, UTP3 - utp3, small subunit (ssu) processome component, homolog (s. cerevisiae), TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), RPF1 - ribosome production factor 1 homolog (s. cerevisiae), TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), LIN28B - lin-28 homolog b (c. elegans), LCMT2 - leucine carboxyl methyltransferase 2, EXOSC4 - exosome component 4, NOP10 - nop10 ribonucleoprotein, TP53RK - tp53 regulating kinase, TRMT10C - trna methyltransferase 10 homolog c (s. cerevisiae), MOCS3 - molybdenum cofactor synthesis 3, DCAF13 - ddb1 and cul4 associated factor 13, YBEY - ybey metallopeptidase (putative), DDX56 - dead (asp-glu-ala-asp) box helicase 56]" GO:0018192 enzyme active site formation via cysteine modification to L-cysteine persulfide 5.55E-04 4.02E-01 "1,801.00" 7204 1 4 1 [MOCS3 - molybdenum cofactor synthesis 3] GO:0098822 peptidyl-cysteine modification to L-cysteine persulfide 5.55E-04 3.80E-01 "1,801.00" 7204 1 4 1 [MOCS3 - molybdenum cofactor synthesis 3] GO:0044085 cellular component biogenesis 7.96E-04 5.15E-01 3.28 7204 48 594 13 "[LTV1 - ltv1 homolog (s. cerevisiae), BYSL - bystin-like, SERINC1 - serine incorporator 1, ZNF622 - zinc finger protein 622, CEBPZ - ccaat/enhancer binding protein (c/ebp), zeta, RIOK1 - rio kinase 1, PEX11A - peroxisomal biogenesis factor 11 alpha, PAK1IP1 - pak1 interacting protein 1, RPS15 - ribosomal protein s15, NOC2L - nucleolar complex associated 2 homolog (s. cerevisiae), TGS1 - trimethylguanosine synthase 1, DHX37 - deah (asp-glu-ala-his) box polypeptide 37, URB2 - urb2 ribosome biogenesis 2 homolog (s. cerevisiae)]"