Compound ID,Structure,"Binding affinity to AKT1 (Kd, nM)","Binding affinity to AKT2 (Kd, nM)","Binding affinity to AKT3 (Kd, nM)",Activity in reducing AKT protein levels in BT-474 cells  at 1 uM by western blotting,DC50 in PC3 Cells (nM),GI50 in PC3 Cells (uM),GI50 in MDA-MB-468 Cells (uM)
3,ClC1=CC=C([C@H](CCN2CCN(C(COCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
4,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
5,ClC1=CC=C([C@H](CCN2CCN(C(COCCOCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
6,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
7,ClC1=CC=C([C@H](CCN2CCN(C(COCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
8,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
9,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
10,ClC1=CC=C([C@H](CCN2CCN(C(COCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
11,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
12,ClC1=CC=C([C@H](CCN2CCN(C(CCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
13,ClC1=CC=C([C@H](CCN2CCN(C(CCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
14,ClC1=CC=C([C@H](CCN2CCN(C(CCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
15,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
16,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
17,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
18,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
19,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
20,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,26 ± 6.3,400 ± 200,88 ± 140,Active,46 ± 21,0.8 ± 0.3,1.0 ± 0.3
21,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
22,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
23,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
24,ClC1=CC=C([C@H](CCN2CCN(C(CNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
25,ClC1=CC=C([C@H](CCN2CCN(C(CCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
26,ClC1=CC=C([C@H](CCN2CCN(C(CCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
27,ClC1=CC=C([C@H](CCN2CCN(C(CCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
28,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
29,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
30,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
31,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
32,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
33,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
34,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
35,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,4.8 ± 5.6,160 ± 120,22 ± 8.8,Active,430 ± 300,10.8 ± 5.6,4.8 ± 1.9
36,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCOCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
37,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
38,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
39,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCNC3=C(CN(C4CCC(NC4=O)=O)C5=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
40,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCOC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Inactive,Not determined,Not determined,Not determined
41,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCCC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,Not determined,Not determined,Not determined,Active,Not determined,Not determined,Not determined
42,ClC1=CC=C([C@H](CCN2CCN(C(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](OCC6=CC=CC=C6)C3)=O)=O)=O)CC2)NC(C7(CCN(C8=NC=NC9=C8C=CN9)CC7)N)=O)C=C1,150 ± 130,>10000,2900 ± 2700,Not determined,Inactive,Inactive,Inactive
43,ClC1=CC=C([C@H](CCN2CCN(C(CCOCCOCCOCCOCCOCCNC3=C(C(N(C4CCC(N(C)C4=O)=O)C5=O)=O)C5=CC=C3)=O)CC2)NC(C6(CCN(C7=NC=NC8=C7C=CN8)CC6)N)=O)C=C1,5.5 ±2.1,360 ± 200,23 ± 7.9,Not determined,Inactive,Inactive,Inactive