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clearfix"> <div class="panel-display panels-960-layout jcore-2col-layout"> <div class="panel-row-wrapper panel-row-first clearfix"> <div class="top-wrapper"> <div class="panel-panel panel-region-top"> <div class="inside"> <div class="panel-pane pane-highwire-article-citation no-margin-bottom"> <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node41334" data-apath="/kidney360/early/2021/11/04/KID.0003622021.atom" data-hw-author-tooltip-instance="highwire_author_tooltip" data-node-nid="41334" data-pisa="kidney360;KID.0003622021v1" data-pisa-master="kidney360;KID.0003622021" id="node41334--21800745255"> <div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-asnjnls-styles-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a"> <div class="highwire-cite-overline"> <span class="highwire-cite-metadata-art-cat highwire-cite-metadata">Original Investigation</span> </div> <h1 class="highwire-cite-title" id="page-title">Modelling and prevention of acute kidney injury through ischemia and reperfusion in a combined human renal proximal tubule/blood vessel-on-a-chip</h1> <div class="highwire-cite-authors"> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Marianne K Vormann</span>, <span class="highwire-citation-author" data-delta="1">Laura M Tool</span>, <span class="highwire-citation-author" data-delta="2">Masato Ohbuchi</span>, <span class="highwire-citation-author" data-delta="3">Linda Gijzen</span>, <span class="highwire-citation-author" data-delta="4">Remko van Vught</span>, <span class="highwire-citation-author" data-delta="5">Thomas Hankemeier</span>, <span class="highwire-citation-author" data-delta="6">Fumiko Kiyonaga</span>, <span class="highwire-citation-author" data-delta="7">Tetsuhiro Kawabe</span>, <span class="highwire-citation-author" data-delta="8">Takayuki Goto</span>, <span class="highwire-citation-author" data-delta="9">Akira Fujimori</span>, <span class="highwire-citation-author" data-delta="10">Paul Vulto</span>, <span class="highwire-citation-author" data-delta="11">Henriette L Lanz</span> and <span class="highwire-citation-author" data-delta="12">Kazuhiro Tetsuka</span></span> </div> <div class="highwire-cite-metadata"> <span class="highwire-cite-metadata-journal highwire-cite-metadata">Kidney360 </span> <span class="highwire-cite-metadata-date highwire-cite-metadata">November 2021, </span> <span class="highwire-cite-metadata-pages highwire-cite-metadata">10.34067/KID.0003622021; </span> <span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.34067/KID.0003622021 </span> </div> </div> <div id="hw-article-author-popups-node41334--21800745255" style="display: none;"> <div class="author-tooltip-0"> <div class="author-tooltip-name">Marianne K Vormann </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">1</span>Mimetas BV, Netherlands</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-1"> <div class="author-tooltip-name">Laura M Tool </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">1</span>Mimetas BV, Netherlands</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-2"> <div class="author-tooltip-name">Masato Ohbuchi </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">2</span>Astellas Pharma, Japan</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-3"> <div class="author-tooltip-name">Linda Gijzen </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">3</span>Model Development, Mimetas BV, Netherlands</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link">Search for this author on this site</li> <li class="author-orcid-link last">ORCID record for Linda Gijzen</li> </ul> </div> <div class="author-tooltip-4"> <div class="author-tooltip-name">Remko van Vught </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">1</span>Mimetas BV, Netherlands</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-5"> <div class="author-tooltip-name">Thomas Hankemeier </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">4</span>Analytical Biosciences, Leiden University, Netherlands</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link">Search for this author on this site</li> <li class="author-orcid-link last">ORCID record for Thomas Hankemeier</li> </ul> </div> <div class="author-tooltip-6"> <div class="author-tooltip-name">Fumiko Kiyonaga </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">5</span>Astellas Pharma, Inc, Japan</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-7"> <div class="author-tooltip-name">Tetsuhiro Kawabe </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">2</span>Astellas Pharma, Japan</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-8"> <div class="author-tooltip-name">Takayuki Goto </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">2</span>Astellas Pharma, Japan</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-9"> <div class="author-tooltip-name">Akira Fujimori </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">2</span>Astellas Pharma, Japan</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-10"> <div class="author-tooltip-name">Paul Vulto </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">1</span>Mimetas BV, Netherlands</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link">Search for this author on this site</li> <li class="author-orcid-link last">ORCID record for Paul Vulto</li> </ul> </div> <div class="author-tooltip-11"> <div class="author-tooltip-name">Henriette L Lanz </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation"><span class="nlm-sup">1</span>Mimetas BV, Netherlands</div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link">Search for this author on this site</li> <li class="author-orcid-link">ORCID record for Henriette L Lanz</li> <li class="author-corresp-email-link last"> <span>For correspondence: h.lanz@mimetas.com</span> </li> </ul> </div> <div 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