Table S2. Differential expressed genes responded to hY4F overexpression in A549 cells identified by mRNA sequencing. Geneid hY4F_mimic_rep1 hY4F_mimic_rep2 hY4F_mimic_rep3 NC_mimic_rep1 NC_mimic_rep2 NC_mimic_rep3 logFC logCPM F PValue FDR uniprotAc Refseq pfam interpro eggNOG "GO(GO_term,class,description)" "KEGG(KO,pathway,description)" VWA1 2.433539757 2.722811573 3.068892042 1.99457327 2.013057351 1.114100634 0.824899997 3.525875722 6.692786743 0.037844309 0.742896758 "K7DPX8,von Willebrand factor A domain containing 1" "XP_016807627.1,von Willebrand factor A domain-containing protein 1 isoform X1" "PF00041,ibronectin type III domain;PF00092,von Willebrand factor type A domain" "IPR003961,Fibronectin type III;IPR002035,von Willebrand factor, type A;IPR013783,Immunoglobulin-like fold;IPR036465,von Willebrand factor A-like domain superfamily;IPR036116,Fibronectin type III superfamily" "ENOG410XNMM,-;KOG3544,Collagens (type IV and type XIII), and related proteins" "GO:0005614,cellular_component,interstitial matrix;GO:0005604,cellular_component,basement membrane;GO:0005578,,;GO:0031012,cellular_component,extracellular matrix;GO:0030198,biological_process,extracellular matrix organization;GO:0048266,biological_process,behavioral response to pain;GO:0042802,molecular_function,identical protein binding;GO:0005576,cellular_component,extracellular region" - FAAP20 0.79126539 0.999826098 1.354002371 0.670834364 0.725326993 0.560537615 0.840507501 3.263939062 6.115687519 0.044507099 0.742896758 "K6ZMW6,Chromosome 1 open reading frame 86" "XP_016807968.1,Fanconi anemia core complex-associated protein 20 isoform X3" "PF15750,Ubiquitin-binding zinc-finger;PF15751,AAP20 FANCA interaction domain" "IPR031491,FAAP20, FANCA interaction domain;IPR031490,FAAP20 ubiquitin-binding zinc-finger" "ENOG410Y5B2,-;ENOG410J1M8,-" "GO:0043130,molecular_function,ubiquitin binding" - DHRS3 22.9061821 25.4049285 22.63779577 15.76167284 18.74330998 11.1221571 0.755274191 5.895981298 8.432223752 0.023537312 0.742896758 "G3RG93,Dehydrogenase/reductase 3" "XP_018866893.1,-" "PF02719,Polysaccharide biosynthesis protein;PF08659,KR domain;PF13561,noyl-(Acyl carrier protein) reductase;PF00106,short chain dehydrogenase" "IPR036291,NAD(P)-binding domain superfamily;IPR002347,Short-chain dehydrogenase/reductase SDR;IPR032969,Short-chain dehydrogenase/reductase 3" - "GO:0004745,molecular_function,retinol dehydrogenase activity;GO:0001523,biological_process,retinoid metabolic process;GO:0003151,biological_process,outflow tract morphogenesis;GO:0060021,biological_process,roof of mouth development;GO:0030278,biological_process,regulation of ossification;GO:0060411,biological_process,cardiac septum morphogenesis;GO:0048387,biological_process,negative regulation of retinoic acid receptor signaling pathway;GO:0042572,biological_process,retinol metabolic process;GO:0016020,cellular_component,membrane;GO:0060349,biological_process,bone morphogenesis;GO:0055114,biological_process,oxidation-reduction process;GO:0016021,cellular_component,integral component of membrane" - RSC1A1 1.359871896 1.219229785 0.478326533 2.063540438 1.659077206 2.163555601 -0.900278475 1.460394818 6.317969187 0.042007318 0.742896758 "H2RBH2,Regulator of solute carriers 1" - - - - - - SYTL1 0.468227143 0.412986698 0.198517504 0.224810517 0.214218242 0.146103835 0.949842711 0.663029386 7.313180247 0.031247174 0.742896758 "A8KAH3,cDNA FLJ75170, highly similar to Homo sapiens synaptotagmin-like 1, mRNA" - "PF00168,C2 domain" "IPR000008,C2 domain;IPR028378,Synaptotagmin-like protein 1;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR010911,Rab-binding domain;IPR035892,C2 domain superfamily" "ENOG41107B6,-;ENOG410IT3I,-" "GO:0017137,molecular_function,Rab GTPase binding;GO:0006886,biological_process,intracellular protein transport;GO:0005622,cellular_component,intracellular;GO:0006887,biological_process,exocytosis" - TMEM54 2.88304998 2.932659467 3.372590258 2.046042394 2.472224079 1.66329014 0.704662403 1.90198819 6.204334138 0.042451775 0.742896758 "G3QL58,Transmembrane protein 54" "XP_004025444.1,transmembrane protein 54 isoform X2" "PF12304,Beta-casein like protein" "IPR020977,Beta-casein-like" - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - PHC2 3.928399438 4.956211876 4.870323975 3.23508261 3.819569509 2.52897796 0.6512015 4.322570734 5.864503473 0.047152087 0.742896758 "H2PYL7,Uncharacterized protein" "XP_009451544.1,polyhomeotic-like protein 2 isoform X2;XP_009451553.1,-" "PF00536,SAM domain (Sterile alpha motif);PF16616,Unstructured region on Polyhomeotic-like protein 1 and 2" "IPR038603,FCS-type zinc finger superfamily;IPR012313,Zinc finger, FCS-type;IPR013761,Sterile alpha motif/pointed domain superfamily;IPR001660,Sterile alpha motif domain" "ENOG410IDZN,-;ENOG4111F0Y,-" "GO:0007283,biological_process,spermatogenesis;GO:0000792,cellular_component,heterochromatin;GO:0031519,cellular_component,PcG protein complex;GO:0035102,cellular_component,PRC1 complex;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0005654,cellular_component,nucleoplasm" - CLSPN 6.678476395 5.540478719 3.51001155 11.78771495 7.337325922 32.86477344 -1.685293588 5.922644664 8.050715452 0.026627158 0.742896758 "Q1RMC5,Claspin homolog" - - "IPR024146,Claspin" "KOG4156,Claspin, protein mediating phosphorylation and activation of Chk1 protein kinase in the DNA replication checkpoint response;ENOG410Y041,-" - - EVA1B 2.775890444 3.110999204 3.09194063 2.246001248 2.116659193 1.309961165 0.790901635 1.605950059 6.999925626 0.034052292 0.742896758 "F7CFD0,Eva-1 homolog B" "XP_001499105.2,protein eva-1 homolog B" "PF14851,AM176 family" - "ENOG4111P45,-;ENOG410IYHF,-" "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - C1orf50 2.30070311 2.145267651 2.055515566 1.472852835 1.422169992 1.220966432 0.769234259 1.469542679 10.25824232 0.01555029 0.742896758 "H2PYT8,Chromosome 1 open reading frame 50" - "PF10504,Protein of unknown function (DUF2452)" "IPR019534,Protein of unknown function DUF2452" "ENOG410IE7Q,-;ENOG4111ERT,-" "GO:0042802,molecular_function,identical protein binding" - RP5-994D16.12 2.545724578 2.252795903 2.229470037 1.507758427 1.521231029 1.39538074 0.775388484 1.405916867 10.28816914 0.015451415 0.742896758 "B4DSR2,cDNA FLJ52234" - - - "ENOG410IE7Q,-;ENOG4111ERT,-" - - PDZK1IP1 3.116924736 3.048614014 7.177725383 2.161659059 2.317285513 1.906913566 1.255417398 2.333819994 6.688110224 0.037892816 0.742896758 "A0A096N1Z7,Uncharacterized protein" - "PF15807,Membrane-associated protein 117 kDa, PDZK1-interacting protein 1" - - - - COA7 4.831436022 4.138967773 3.619662828 6.64521023 5.648298141 8.869050396 -0.662456993 4.544420598 6.272944299 0.041770692 0.742896758 "H2PZ14,Sel1 repeat containing 1" "NP_001229523.1,-" "PF08238,Sel1 repeat" "IPR006597,Sel1-like repeat;IPR011990,Tetratricopeptide-like helical domain superfamily" "KOG4014,Uncharacterized conserved protein (contains TPR repeat);COG0790,FOG: TPR repeat, SEL1 subfamily" "GO:0005739,cellular_component,mitochondrion;GO:0005634,cellular_component,nucleus" - LRP8 4.904204287 4.785594143 3.292353517 7.275596271 6.258118579 9.12855722 -0.728532278 5.914698197 8.200315747 0.024907549 0.742896758 "H2PZ23,Uncharacterized protein" "XP_009456320.1,low-density lipoprotein receptor-related protein 8 isoform X3" "PF14670,Coagulation Factor Xa inhibitory site;PF00057,Low-density lipoprotein receptor domain class A;PF00058,Low-density lipoprotein receptor repeat class B" "IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR018097,EGF-like calcium-binding, conserved site;IPR000033,LDLR class B repeat;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR011042,Six-bladed beta-propeller, TolB-like;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR036055,LDL receptor-like superfamily" "ENOG410IPT5,-;ENOG410YQ6J,-" "GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005901,cellular_component,caveola;GO:0005509,molecular_function,calcium ion binding;GO:0016020,cellular_component,membrane;GO:0030229,molecular_function,very-low-density lipoprotein particle receptor activity;GO:0043235,cellular_component,receptor complex;GO:0006897,biological_process,endocytosis;GO:0016021,cellular_component,integral component of membrane" - JUN 11.5139662 12.84186491 14.98209233 47.99141458 65.53808007 11.55522665 -1.510249999 6.563336985 6.39143848 0.041145361 0.742896758 "K6ZFP8,Jun proto-oncogene" "XP_513442.2,-" "PF00170,bZIP transcription factor;PF03957,Jun-like transcription factor" "IPR002112,Transcription factor Jun;IPR004827,Basic-leucine zipper domain;IPR015558,Transcription Factor c-Jun/v-Jun;IPR005643,Jun-like transcription factor;IPR008917,Transcription factor, Skn-1-like, DNA-binding domain superfamily" - "GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0003677,molecular_function,DNA binding;GO:0006351,biological_process,transcription, DNA-templated" "K04448,ko05200,Pathways in cancer;K04448,ko05142,Chagas disease (American trypanosomiasis);K04448,ko04013,MAPK signaling pathway - fly;K04448,ko01522,Endocrine resistance;K04448,ko05321,Inflammatory bowel disease (IBD);K04448,ko04915,Estrogen signaling pathway;K04448,ko05166,HTLV-I infection;K04448,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K04448,ko05168,Herpes simplex infection;K04448,ko05211,Renal cell carcinoma;K04448,ko05140,Leishmaniasis;K04448,ko04662,B cell receptor signaling pathway;K04448,ko04010,MAPK signaling pathway;K04448,ko04024,cAMP signaling pathway;K04448,ko05133,Pertussis;K04448,ko04722,Neurotrophin signaling pathway;K04448,ko05031,Amphetamine addiction;K04448,ko04620,Toll-like receptor signaling pathway;K04448,ko05210,Colorectal cancer;K04448,ko05132,Salmonella infection;K04448,ko04921,Oxytocin signaling pathway;K04448,ko05231,Choline metabolism in cancer;K04448,ko04912,GnRH signaling pathway;K04448,ko04310,Wnt signaling pathway;K04448,ko04380,Osteoclast differentiation;K04448,ko05161,Hepatitis B;K04448,ko04510,Focal adhesion;K04448,ko04214,Apoptosis - fly;K04448,ko05203,Viral carcinogenesis;K04448,ko04210,Apoptosis;K04448,ko04933,AGE-RAGE signaling pathway in diabetic complications;K04448,ko05164,Influenza A;K04448,ko05323,Rheumatoid arthritis;K04448,ko04660,T cell receptor signaling pathway;K04448,ko04012,ErbB signaling pathway;K04448,ko05030,Cocaine addiction;K04448,ko04932,Non-alcoholic fatty liver disease (NAFLD);K04448,ko04668,TNF signaling pathway;K04448,ko05169,Epstein-Barr virus infection" FGGY 0.176416216 0.170674325 0.161878209 0.142399164 0.095918666 0.072599868 0.828426534 0.789042699 6.199785993 0.042480013 0.742896758 "H2PZ49,FGGY carbohydrate kinase domain containing" - "PF02782,Y family of carbohydrate kinases, C-terminal domain;PF00370,Y family of carbohydrate kinases, N-terminal domain" "IPR018484,Carbohydrate kinase, FGGY, N-terminal;IPR006003,FGGY carbohydrate kinase, pentulose kinase;IPR000577,Carbohydrate kinase, FGGY;IPR018485,Carbohydrate kinase, FGGY, C-terminal" "ENOG410IR1J,-;COG1069,Ribulose kinase" "GO:0005975,biological_process,carbohydrate metabolic process;GO:0019150,molecular_function,D-ribulokinase activity;GO:0016773,molecular_function,phosphotransferase activity, alcohol group as acceptor;GO:0005623,cellular_component,cell;GO:0019321,biological_process,pentose metabolic process;GO:0070050,biological_process,neuron cellular homeostasis;GO:0046835,biological_process,carbohydrate phosphorylation" - DNAJC6 0.459906824 0.49907866 0.396748266 0.73497771 0.651200925 0.808204973 -0.600605157 2.047701076 6.63846296 0.03749441 0.742896758 "G7NW24,Uncharacterized protein" - "PF10409,C2 domain of PTEN tumour-suppressor protein;PF00226,naJ domain" "IPR014020,Tensin phosphatase, C2 domain;IPR036869,Chaperone J-domain superfamily;IPR029023,Tensin-type phosphatase domain;IPR029021,Protein-tyrosine phosphatase-like;IPR001623,DnaJ domain" - - - LRRIQ3 0.245198198 0.177261527 0.154682031 0.385599677 0.409702477 0.313065613 -0.846178898 1.303739613 10.41472725 0.015042211 0.742896758 "H2R8Z4,Leucine rich repeats and IQ motif containing 3" "XP_513491.2,leucine-rich repeat and IQ domain-containing protein 3" "PF12799,Leucine Rich repeats (2 copies)" "IPR001611,Leucine-rich repeat;IPR025875,Leucine rich repeat 4;IPR032675,Leucine-rich repeat domain superfamily;IPR000048,IQ motif, EF-hand binding site" "KOG0531,Protein phosphatase 1, regulatory subunit, and related proteins;COG4886,Leucine-rich repeat (LRR) protein" - - NEXN 2.647039491 2.506672074 1.260567254 3.537370177 3.653198746 4.265789904 -0.780323185 3.702568267 8.349238855 0.02418146 0.742896758 "K7DM11,Nexilin" - "PF07679,Immunoglobulin I-set domain" - - - - SSX2IP 2.934609534 2.809505519 1.830641298 3.951075913 3.652824923 5.886591549 -0.765414437 4.90923244 7.329870242 0.031605321 0.742896758 "H2PZB0,SSX family member 2 interacting protein" "XP_016785124.1,afadin- and alpha-actinin-binding protein isoform X2" "PF11559,Afadin- and alpha -actinin-Binding" "IPR021622,Afadin/alpha-actinin-binding" "ENOG410XWZ9,-;ENOG410IED3,-" - - CCDC18 5.201013098 4.697900169 2.562651598 7.492171146 6.173457798 9.321607376 -0.827691767 5.035285884 8.167439167 0.025675833 0.742896758 "J3KP97,Coiled-coil domain-containing protein 18" - - "IPR029613,Coiled-coil domain-containing protein 18/Cytoskeletal protein Sojo" "ENOG4111YKF,-;ENOG410IJJN,-" - - DNTTIP2 16.8648953 15.90009254 12.25629837 21.88713246 22.19678636 29.54330903 -0.626493577 7.204514941 6.121312541 0.043462055 0.742896758 "H2PZF3,Deoxynucleotidyltransferase, terminal, interacting protein 2" - "PF08698,cf2 pre-rRNA processing" "IPR014810,Fcf2 pre-rRNA processing" "ENOG410Z9Q4,-;KOG3100,Uncharacterized conserved protein" "GO:0005730,cellular_component,nucleolus;GO:0005634,cellular_component,nucleus;GO:0016740,molecular_function,transferase activity" - SASS6 0.893343169 0.8622677 0.434130703 1.271716215 0.982344682 2.316441398 -1.017569347 2.160157178 6.055098963 0.045293955 0.742896758 "H2PZH1,Spindle assembly 6 homolog" - "PF16531,Centriolar protein SAS N-terminal" "IPR032396,Spindle assembly abnormal protein 6, N-terminal;IPR038558,SAS-6, N-terminal domain superfamily" "ENOG410XQWJ,-;ENOG410IF03,-" "GO:0098536,cellular_component,deuterosome;GO:0007099,biological_process,centriole replication;GO:0005814,cellular_component,centriole;GO:0005815,cellular_component,microtubule organizing center;GO:0005813,cellular_component,centrosome;GO:0005829,cellular_component,cytosol;GO:0051298,biological_process,centrosome duplication" - TTF2 1.320736009 1.298518751 0.721036962 1.77907776 1.47985037 3.13635403 -0.885567695 4.0337374 5.823336917 0.048479293 0.742896758 "A0A024R0F1,Transcription termination factor, RNA polymerase II, isoform CRA_a" "NP_003585.3,transcription termination factor 2;XP_016858044.1,-" "PF00271,Helicase conserved C-terminal domain;PF00176,SNF2 family N-terminal domain;PF06839,RF zinc finger" "IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR002464,DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;IPR010666,Zinc finger, GRF-type;IPR038718,SNF2-like, N-terminal domain superfamily;IPR000330,SNF2-related, N-terminal domain;IPR001650,Helicase, C-terminal" "ENOG410INU3,-;ENOG410XPDU,-" "GO:0005829,cellular_component,cytosol;GO:0005524,molecular_function,ATP binding;GO:0008270,molecular_function,zinc ion binding" "K15173,ko04918,Thyroid hormone synthesis" SPAG17 0.173519388 0.210352878 0.167629614 0.34732929 0.304129417 0.365368356 -0.783129598 1.336150349 9.259373928 0.019382134 0.742896758 "H2PZS5,Uncharacterized protein" "XP_513687.2,sperm-associated antigen 17 isoform X2" "PF14874,lagellar-associated PapD-like" "IPR026173,Sperm-associated antigen 17" "ENOG410ZGKQ,-;ENOG410IGU0,-" "GO:0003351,biological_process,epithelial cilium movement;GO:1904158,biological_process,axonemal central apparatus assembly;GO:1990716,cellular_component,axonemal central apparatus" - PEX11B 2.400492039 2.42241866 2.894942523 1.756268825 1.905952949 1.676864325 0.662127626 2.043236396 5.99287526 0.045134679 0.742896758 "H2RI44,Peroxisomal biogenesis factor 11 beta" "XP_001162089.1,-;XP_009426190.1,-" "PF05648,Peroxisomal biogenesis factor 11 (PEX11)" "IPR008733,Peroxisomal biogenesis factor 11" "ENOG4111NS6,-;KOG4186,Peroxisomal biogenesis protein (peroxin)" "GO:0044375,biological_process,regulation of peroxisome size;GO:0016559,biological_process,peroxisome fission;GO:0007031,biological_process,peroxisome organization;GO:0032991,cellular_component,protein-containing complex;GO:0042803,molecular_function,protein homodimerization activity;GO:0005779,cellular_component,integral component of peroxisomal membrane;GO:0005778,cellular_component,peroxisomal membrane;GO:0051260,biological_process,protein homooligomerization;GO:0016020,cellular_component,membrane;GO:0005777,cellular_component,peroxisome;GO:0016021,cellular_component,integral component of membrane" "K13352,ko04146,Peroxisome" TCHH 0.387127696 0.254605032 0.288773831 0.615300853 0.622954436 0.991375614 -1.168510873 1.889418416 12.36509925 0.010658914 0.742896758 "G3RXF1,Trichohyalin" - "PF01023,S-100/ICaBP type calcium binding domain" "IPR018247,EF-Hand 1, calcium-binding site;IPR034325,S-100;IPR013787,S100/CaBP-9k-type, calcium binding, subdomain;IPR002048,EF-hand domain;IPR001751,S100/Calbindin-D9k, conserved site;IPR011992,EF-hand domain pair" - "GO:0046914,molecular_function,transition metal ion binding;GO:0046872,molecular_function,metal ion binding;GO:0005509,molecular_function,calcium ion binding" - CENPL 1.168648559 1.203440744 1.08280512 2.141017689 1.443167586 2.527260039 -0.726093253 2.972924053 6.229054939 0.042718883 0.742896758 "H2QXJ0,Uncharacterized protein" - "PF13092,Kinetochore complex Sim4 subunit Fta1" "IPR025204,Centromere subunit L" "ENOG410XZDF,-;ENOG410IIZ1,-" - - QSOX1 4.726057496 5.328727337 3.632502418 3.57282366 3.627779926 2.027464221 0.66802619 5.151542769 6.173675179 0.043036869 0.742896758 "H2Q0P8,Sulfhydryl oxidase" "XP_009437523.1,sulfhydryl oxidase 1 isoform X1" "PF00085,Thioredoxin;PF04777,rv1 / Alr family" "IPR017905,ERV/ALR sulfhydryl oxidase domain;IPR013766,Thioredoxin domain;IPR036249,Thioredoxin-like superfamily;IPR036774,ERV/ALR sulfhydryl oxidase domain superfamily" "ENOG410XVJT,-;KOG1731,FAD-dependent sulfhydryl oxidase/quiescin and related proteins" "GO:0005794,cellular_component,Golgi apparatus;GO:0003756,molecular_function,protein disulfide isomerase activity;GO:0070062,cellular_component,extracellular exosome;GO:0045171,cellular_component,intercellular bridge;GO:0045454,biological_process,cell redox homeostasis;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0016491,molecular_function,oxidoreductase activity;GO:0030173,cellular_component,integral component of Golgi membrane;GO:0016020,cellular_component,membrane;GO:0055114,biological_process,oxidation-reduction process;GO:0016971,molecular_function,flavin-linked sulfhydryl oxidase activity;GO:0016242,biological_process,negative regulation of macroautophagy;GO:0016972,molecular_function,thiol oxidase activity;GO:0016021,cellular_component,integral component of membrane;GO:0005615,cellular_component,extracellular space" - ASPM 9.87092361 9.15359678 5.634833499 13.46348179 10.80073721 22.02418617 -0.850928657 6.999649298 5.792792111 0.048920965 0.742896758 "K7CY36,Asp" - "PF15780,Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin;PF00307,Calponin homology (CH) domain;PF00612,IQ calmodulin-binding motif" "IPR001715,Calponin homology domain;IPR036872,CH domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR031549,Abnormal spindle-like microcephaly-associated protein, ASH domain;IPR013783,Immunoglobulin-like fold;IPR000048,IQ motif, EF-hand binding site;IPR016024,Armadillo-type fold;IPR029955,Abnormal spindle-like microcephaly-associated protein" "KOG0165,Microtubule-associated protein Asp;ENOG410XSAR,-" "GO:0007051,biological_process,spindle organization" - KIF14 3.682760582 3.448302972 1.049399905 5.976175771 5.385408233 10.75658671 -1.41850544 5.17060135 8.642073805 0.023108753 0.742896758 "G3RD87,Kinesin family member 14" "XP_018884025.1,kinesin-like protein KIF14" "PF16183,Kinesin-associated;PF00225,Kinesin motor domain;PF00498,HA domain" "IPR019821,Kinesin motor domain, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR032405,Kinesin-associated;IPR000253,Forkhead-associated (FHA) domain;IPR008984,SMAD/FHA domain superfamily;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR027640,Kinesin-like protein" - "GO:0003774,molecular_function,motor activity;GO:0005524,molecular_function,ATP binding;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity" - LGR6 1.400769927 1.34516019 1.488886573 0.730433881 0.814092979 0.806013417 0.967952085 2.372535521 15.02993767 0.00639567 0.742896758 "H2Q0W9,Leucine rich repeat containing G protein-coupled receptor 6" "XP_016791279.1,leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1" "PF13855,Leucine rich repeat" "IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily;IPR002131,Glycoprotein hormone receptor family;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR000276,G protein-coupled receptor, rhodopsin-like" "KOG0619,FOG: Leucine rich repeat;KOG2087,Glycoprotein hormone receptor;COG4886,Leucine-rich repeat (LRR) protein" "GO:1990523,biological_process,bone regeneration;GO:0042246,biological_process,tissue regeneration;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0016500,molecular_function,protein-hormone receptor activity;GO:0030177,biological_process,positive regulation of Wnt signaling pathway;GO:0016020,cellular_component,membrane;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0031982,cellular_component,vesicle;GO:0016021,cellular_component,integral component of membrane;GO:0030335,biological_process,positive regulation of cell migration" - G0S2 6.981774938 6.064151504 12.2600172 4.555843356 5.196270679 3.611317882 1.09778323 2.552925423 6.920518407 0.035577957 0.742896758 "H2Q121,G0/G1 switch protein 2" "XP_016793527.1,-;XP_514164.1,-" "PF15103,0/G1 switch protein 2" "IPR016821,G0/G1 switch protein 2" "ENOG410J22N,-;ENOG410YZQR,-" "GO:0006915,biological_process,apoptotic process;GO:0016021,cellular_component,integral component of membrane;GO:2001238,biological_process,positive regulation of extrinsic apoptotic signaling pathway;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0097191,biological_process,extrinsic apoptotic signaling pathway" - ATF3 0.652951692 0.768630551 1.042668964 3.787924725 4.709205779 0.740452306 -1.732173694 2.946657018 6.890553839 0.035865753 0.742896758 "G1QRJ9,Activating transcription factor 3" "XP_012362230.1,-;XP_003273105.1,-;XP_003273102.1,-" "PF00170,bZIP transcription factor" "IPR000837,AP-1 transcription factor;IPR029812,cAMP-dependent transcription factor ATF-3;IPR004827,Basic-leucine zipper domain" "KOG1414,Transcriptional activator FOSB/c-Fos and related bZIP transcription factors;ENOG4111CH5,-" "GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0006094,biological_process,gluconeogenesis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0010628,biological_process,positive regulation of gene expression;GO:0005634,cellular_component,nucleus;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0042802,molecular_function,identical protein binding;GO:0003677,molecular_function,DNA binding;GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0030968,biological_process,endoplasmic reticulum unfolded protein response;GO:0000976,molecular_function,transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000977,molecular_function,RNA polymerase II regulatory region sequence-specific DNA binding;GO:1990622,cellular_component,CHOP-ATF3 complex;GO:0005730,cellular_component,nucleolus;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:1903984,biological_process,positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1990440,biological_process,positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0034198,biological_process,cellular response to amino acid starvation" "K09032,ko05166,HTLV-I infection" PTPN14 0.85008911 0.720678526 0.282377401 1.109128231 1.020426245 1.268684398 -0.836715073 4.008072698 5.740788505 0.049685254 0.742896758 "A8K6H6,Tyrosine-protein phosphatase non-receptor type" "NP_005392.2,tyrosine-protein phosphatase non-receptor type 14" "PF00102,Protein-tyrosine phosphatase;PF09379,RM N-terminal domain;PF00373,RM central domain;PF09380,RM C-terminal PH-like domain" "IPR019747,FERM conserved site;IPR029021,Protein-tyrosine phosphatase-like;IPR014392,Protein-tyrosine phosphatase, non-receptor type-14, -21;IPR035963,FERM superfamily, second domain;IPR018979,FERM, N-terminal;IPR000387,Tyrosine specific protein phosphatases domain;IPR000299,FERM domain;IPR019748,FERM central domain;IPR000242,PTP type protein phosphatase;IPR011993,PH-like domain superfamily;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR019749,Band 4.1 domain;IPR014352,FERM/acyl-CoA-binding protein superfamily;IPR016130,Protein-tyrosine phosphatase, active site;IPR029071,Ubiquitin-like domain superfamily;IPR018980,FERM, C-terminal PH-like domain" "KOG0792,Protein tyrosine phosphatase PTPMEG, contains FERM domain;COG5599,Protein tyrosine phosphatase" "GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0005737,cellular_component,cytoplasm;GO:0006470,biological_process,protein dephosphorylation;GO:0016311,biological_process,dephosphorylation;GO:0005856,cellular_component,cytoskeleton;GO:0016791,molecular_function,phosphatase activity" - CENPF 32.29883817 29.62215428 9.577476121 48.39271798 37.77546598 83.32525141 -1.227992314 8.845798366 6.243883424 0.042900812 0.742896758 "K7CVC0,Centromere protein F, 350/400kDa" - "PF10481,Cenp-F N-terminal domain;PF10490,Rb-binding domain of kinetochore protein Cenp-F/LEK1;PF10473,Leucine-rich repeats of kinetochore protein Cenp-F/LEK1" "IPR018463,Centromere protein Cenp-F, N-terminal;IPR019513,Centromere protein Cenp-F, leucine-rich repeat-containing domain;IPR018302,Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain" "ENOG410XS5F,-;ENOG410IGJF,-" "GO:0042803,molecular_function,protein homodimerization activity;GO:0008134,molecular_function,transcription factor binding;GO:0070840,molecular_function,dynein complex binding" - HIST3H2A 18.3886588 16.63353895 34.32220016 13.95937553 14.70183388 9.69795719 1.03794843 4.071589457 5.800620317 0.048807265 0.742896758 "A0A091CRS7,Histone H2A type 3" - "PF00125,Core histone H2A/H2B/H3/H4;PF16211,C-terminus of histone H2A" "IPR032454,Histone H2A, C-terminal domain;IPR007125,Histone H2A/H2B/H3;IPR002119,Histone H2A;IPR032458,Histone H2A conserved site;IPR009072,Histone-fold;IPR000164,Histone H3/CENP-A" - "GO:0005694,cellular_component,chromosome;GO:0000786,cellular_component,nucleosome;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0046982,molecular_function,protein heterodimerization activity" - SPRTN 2.142347006 2.153385833 1.338885047 3.18324413 2.743919681 3.303803682 -0.638425265 3.856195477 8.038065954 0.025928639 0.742896758 "A0A024R3U2,Chromosome 1 open reading frame 124, isoform CRA_a" "NP_114407.3,sprT-like domain-containing protein Spartan isoform a" "PF10263,SprT-like family" "IPR006642,Zinc finger, Rad18-type putative;IPR006640,SprT-like" "ENOG410XPXU,-;KOG3931,Uncharacterized conserved protein" "GO:0006281,biological_process,DNA repair;GO:0003677,molecular_function,DNA binding;GO:0005654,cellular_component,nucleoplasm" - CHML 4.135027082 3.776167512 1.909996996 7.412776101 6.494713735 6.99600654 -1.031243253 5.264021953 15.12500748 0.006340625 0.742896758 "K7C4W2,Choroideremia-like" - "PF00996,P dissociation inhibitor" "IPR036188,FAD/NAD(P)-binding domain superfamily;IPR018203,GDP dissociation inhibitor;IPR001738,Rab protein geranylgeranyltransferase component A" - "GO:0005092,molecular_function,GDP-dissociation inhibitor activity;GO:0005968,cellular_component,Rab-protein geranylgeranyltransferase complex;GO:0007264,biological_process,small GTPase mediated signal transduction;GO:0050790,biological_process,regulation of catalytic activity;GO:0018344,biological_process,protein geranylgeranylation;GO:0006886,biological_process,intracellular protein transport" - MCM10 2.448301328 1.909017054 2.827423746 4.745866336 3.065318022 14.88383929 -1.555968969 4.774007616 5.759963556 0.049401614 0.742896758 "H2R2Z4,Uncharacterized protein" - "PF09332,Mcm10 replication factor;PF09329,Primase zinc finger" "IPR015408,Zinc finger, Mcm10/DnaG-type;IPR015411,Replication factor Mcm10, C-terminal" "ENOG41100ZT,-;KOG3056,Protein required for S-phase initiation or completion" "GO:0003697,molecular_function,single-stranded DNA binding;GO:0019899,molecular_function,enzyme binding;GO:0005730,cellular_component,nucleolus;GO:0006270,biological_process,DNA replication initiation;GO:0008283,biological_process,cell proliferation;GO:0006260,biological_process,DNA replication;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0003688,molecular_function,DNA replication origin binding;GO:0042802,molecular_function,identical protein binding;GO:0005634,cellular_component,nucleus;GO:0031298,cellular_component,replication fork protection complex" - VIM 79.89981198 92.47347993 111.0670872 58.93215998 61.37899473 60.05209409 0.789407853 8.673598042 6.987884549 0.034202821 0.742896758 "G3R2A8,Vimentin" "XP_018890043.1,-" "PF00038,Intermediate filament protein;PF04732,Intermediate filament head (DNA binding) region" "IPR027699,Vimentin;IPR018039,Intermediate filament protein, conserved site;IPR006821,Intermediate filament head, DNA-binding domain;IPR001664,Intermediate filament protein" - "GO:0005882,cellular_component,intermediate filament;GO:0005198,molecular_function,structural molecule activity" - C10orf11 0.576494473 0.65435603 0.465639214 0.387282462 0.425475745 0.17273116 0.893034885 1.57771804 6.29072899 0.04233296 0.742896758 "A0A087WWI0,Leucine-rich melanocyte differentiation-associated protein" "NP_001292510.1,leucine-rich melanocyte differentiation-associated protein isoform 1" "PF14580,Leucine-rich repeat" "IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily" "KOG1644,U2-associated snRNP A' protein;COG4886,Leucine-rich repeat (LRR) protein" - - SNCG 5.279181917 5.236723921 5.946093631 3.547382392 4.248142357 2.962277057 0.744183303 2.53541067 7.800125176 0.027527235 0.742896758 "Q6FHG5,Gamma-synuclein" "NP_003078.2,gamma-synuclein isoform 1" "PF01387,Synuclein" "IPR002462,Gamma-synuclein;IPR001058,Synuclein" "ENOG4111VY5,-;ENOG410IYGN,-" "GO:0005515,molecular_function,protein binding;GO:0007268,biological_process,chemical synaptic transmission;GO:0008344,biological_process,adult locomotory behavior;GO:0009306,biological_process,protein secretion;GO:0014059,biological_process,regulation of dopamine secretion;GO:0005737,cellular_component,cytoplasm;GO:0030424,cellular_component,axon;GO:0043025,cellular_component,neuronal cell body;GO:0050808,biological_process,synapse organization;GO:0046928,biological_process,regulation of neurotransmitter secretion" - KIF20B 6.814908059 6.228958434 4.012748384 12.35962662 9.640495407 20.86945386 -1.27042366 6.079600458 12.17642867 0.011055541 0.742896758 "D3DR32,M-phase phosphoprotein 1, isoform CRA_a" - "PF00225,Kinesin motor domain" "IPR019821,Kinesin motor domain, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR028828,Kinesin-like protein KIF20B;IPR027640,Kinesin-like protein" "KOG0247,Kinesin-like protein;COG5059,Kinesin-like protein" "GO:0003774,molecular_function,motor activity;GO:0005524,molecular_function,ATP binding;GO:0007088,biological_process,regulation of mitotic nuclear division;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0000166,molecular_function,nucleotide binding;GO:0003777,molecular_function,microtubule motor activity" - KIF11 13.78092128 13.02318037 6.381476324 22.34301992 16.0746716 38.2088718 -1.166760888 6.454371988 7.873252884 0.027819004 0.742896758 "B2RAM6,cDNA, FLJ95005, highly similar to Homo sapiens kinesin family member 11" - "PF00225,Kinesin motor domain;PF13931,Kinesin-associated microtubule-binding" "IPR019821,Kinesin motor domain, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR001752,Kinesin motor domain;IPR025901,Kinesin-associated microtubule-binding domain;IPR036961,Kinesin motor domain superfamily;IPR027640,Kinesin-like protein" "COG5059,Kinesin-like protein;KOG0243,Kinesin-like protein" "GO:0003777,molecular_function,microtubule motor activity;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0003774,molecular_function,motor activity;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding" - GOLGA7B 0.22773327 0.226277844 0.270827031 0.083308096 0.088203237 0.12983991 1.373283568 0.248543956 12.87354356 0.00928342 0.742896758 "A0A250YAU2,Golgin subfamily A member 7B" "XP_020040584.1,-;XP_020040581.1,-;XP_020040579.1,golgin subfamily A member 7B;XP_020040583.1,-;XP_020040582.1,-" - "IPR019383,Golgin subfamily A member 7/ERF4" - - - CHUK 3.281973354 3.094694708 1.738732138 3.964791708 4.176749217 5.04734012 -0.63847992 4.601286285 6.315353815 0.041086117 0.742896758 "A0A0D9R033,Conserved helix-loop-helix ubiquitous kinase" "XP_007962021.1,inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1" "PF00069,Protein kinase domain;PF12179,I-kappa-kinase-beta NEMO binding domain" "IPR022007,I-kappa-kinase-beta NEMO binding domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain" - "GO:0038061,biological_process,NIK/NF-kappaB signaling;GO:0004672,molecular_function,protein kinase activity;GO:0046982,molecular_function,protein heterodimerization activity;GO:0097110,molecular_function,scaffold protein binding;GO:0005524,molecular_function,ATP binding;GO:0071276,biological_process,cellular response to cadmium ion;GO:0032088,biological_process,negative regulation of NF-kappaB transcription factor activity;GO:0007249,biological_process,I-kappaB kinase/NF-kappaB signaling;GO:0042803,molecular_function,protein homodimerization activity;GO:0071356,biological_process,cellular response to tumor necrosis factor;GO:0034614,biological_process,cellular response to reactive oxygen species;GO:1902741,biological_process,positive regulation of interferon-alpha secretion;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0008384,molecular_function,IkappaB kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0005654,cellular_component,nucleoplasm;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0098586,biological_process,cellular response to virus;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0007252,biological_process,I-kappaB phosphorylation" "K04467,ko05200,Pathways in cancer;K04467,ko04014,Ras signaling pathway;K04467,ko04623,Cytosolic DNA-sensing pathway;K04467,ko05222,Small cell lung cancer;K04467,ko04621,NOD-like receptor signaling pathway;K04467,ko04920,Adipocytokine signaling pathway;K04467,ko04064,NF-kappa B signaling pathway;K04467,ko05215,Prostate cancer;K04467,ko04380,Osteoclast differentiation;K04467,ko04151,PI3K-Akt signaling pathway;K04467,ko04150,mTOR signaling pathway;K04467,ko05131,Shigellosis;K04467,ko04010,MAPK signaling pathway;K04467,ko05145,Toxoplasmosis;K04467,ko05168,Herpes simplex infection;K04467,ko04620,Toll-like receptor signaling pathway;K04467,ko05221,Acute myeloid leukemia;K04467,ko05120,Epithelial cell signaling in Helicobacter pylori infection;K04467,ko04062,Chemokine signaling pathway;K04467,ko05162,Measles;K04467,ko04210,Apoptosis;K04467,ko05161,Hepatitis B;K04467,ko04662,B cell receptor signaling pathway;K04467,ko04668,TNF signaling pathway;K04467,ko05166,HTLV-I infection;K04467,ko05160,Hepatitis C;K04467,ko04068,FoxO signaling pathway;K04467,ko04660,T cell receptor signaling pathway;K04467,ko05220,Chronic myeloid leukemia;K04467,ko05142,Chagas disease (American trypanosomiasis);K04467,ko05212,Pancreatic cancer;K04467,ko05169,Epstein-Barr virus infection;K04467,ko04622,RIG-I-like receptor signaling pathway" GPAM 0.847331816 0.840401548 0.622877904 1.231157605 1.298014778 1.254653772 -0.622011359 3.306844758 9.793195985 0.017198311 0.742896758 "Q6ZMF6,Glycerol-3-phosphate acyltransferase 1, mitochondrial" - "PF01553,Acyltransferase" "IPR002123,Phospholipid/glycerol acyltransferase;IPR028354,Glycerol-3-phosphate acyltransferase, PlsB;IPR022284,Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase" "COG2937,Glycerol-3-phosphate O-acyltransferase;KOG3729,Mitochondrial glycerol-3-phosphate acyltransferase GPAT" "GO:0008654,biological_process,phospholipid biosynthetic process;GO:0044255,biological_process,cellular lipid metabolic process;GO:0006629,biological_process,lipid metabolic process;GO:0102420,molecular_function,sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity;GO:0016740,molecular_function,transferase activity;GO:0031966,cellular_component,mitochondrial membrane;GO:0008374,molecular_function,O-acyltransferase activity;GO:0016024,biological_process,CDP-diacylglycerol biosynthetic process;GO:0005886,cellular_component,plasma membrane;GO:0005739,cellular_component,mitochondrion;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0004366,molecular_function,glycerol-3-phosphate O-acyltransferase activity;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0005741,cellular_component,mitochondrial outer membrane" - HABP2 1.640560066 2.179016735 0.525413641 0.547598924 0.8333192 0.439985042 1.296689235 1.898852287 7.536502146 0.03028056 0.742896758 "G3QIP4,Hyaluronan binding protein 2" "XP_004050163.1,hyaluronan-binding protein 2 isoform X2;XP_018890824.1,-" "PF00089,Trypsin;PF00008,-like domain;PF00051,Kringle domain" "IPR018114,Serine proteases, trypsin family, histidine active site;IPR000001,Kringle;IPR001254,Serine proteases, trypsin domain;IPR033116,Serine proteases, trypsin family, serine active site;IPR009003,Peptidase S1, PA clan;IPR013806,Kringle-like fold;IPR038178,Kringle superfamily;IPR001881,EGF-like calcium-binding domain;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR018056,Kringle, conserved site;IPR001314,Peptidase S1A, chymotrypsin family" - "GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005509,molecular_function,calcium ion binding;GO:0004252,molecular_function,serine-type endopeptidase activity;GO:0008233,molecular_function,peptidase activity;GO:0008236,molecular_function,serine-type peptidase activity;GO:0005576,cellular_component,extracellular region" - MKI67 52.05887354 49.66817616 18.57490167 76.92935036 55.07582737 152.7543904 -1.221954282 9.732321481 5.729359909 0.049855332 0.742896758 "H2Q2S1,Uncharacterized protein" "XP_508147.3,antigen KI-67 isoform X1" "PF08065,K167R (NUC007) repeat;PF15276,Protein phosphatase 1 binding;PF00498,HA domain" "IPR008984,SMAD/FHA domain superfamily;IPR012568,KI67R;IPR000253,Forkhead-associated (FHA) domain;IPR029334,Protein phosphatase 1 binding domain" "ENOG410JR7C,-;ENOG410ZXYW,-" "GO:0005730,cellular_component,nucleolus;GO:0051983,biological_process,regulation of chromosome segregation;GO:0008022,molecular_function,protein C-terminus binding;GO:0007088,biological_process,regulation of mitotic nuclear division;GO:0000793,cellular_component,condensed chromosome;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus" - BNIP3 14.4932976 20.95047864 9.950674033 10.97897971 10.11938434 6.834873056 0.778681683 6.014193525 6.996121781 0.034485025 0.742896758 "Q6NVY4,BNIP3 protein" "NP_004043.3,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3" "PF06553,BNIP3" "IPR010548,BNIP3" "ENOG410IHYW,-;ENOG4111KXP,-" "GO:0005740,cellular_component,mitochondrial envelope;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" "K15464,ko05134,Legionellosis;K15464,ko04068,FoxO signaling pathway" DPYSL4 2.241833314 2.954754666 2.450971664 1.101078068 1.120939286 1.362879307 1.195936378 2.609581486 21.476016 0.002555623 0.742896758 "K7CDM5,Dihydropyrimidinase-like 4" - "PF01979,Amidohydrolase family" "IPR011778,Hydantoinase/dihydropyrimidinase;IPR006680,Amidohydrolase-related;IPR030612,Dihydropyrimidinase-related protein 4;IPR032466,Metal-dependent hydrolase;IPR011059,Metal-dependent hydrolase, composite domain superfamily" "KOG2584,Dihydroorotase and related enzymes;COG0044,Dihydroorotase and related cyclic amidohydrolases" "GO:0005737,cellular_component,cytoplasm;GO:0016787,molecular_function,hydrolase activity;GO:0016810,molecular_function,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0097485,biological_process,neuron projection guidance;GO:0070997,biological_process,neuron death" - RASSF7 9.320925047 11.269825 9.143772165 7.112452834 7.337355493 5.892932844 0.656319731 4.391803428 9.25890997 0.019384185 0.742896758 "A0A024RCE4,Ras association" "XP_016873850.1,-;NP_003466.1,ras association domain-containing protein 7 isoform 1" "PF00788,Ras association (RalGDS/AF-6) domain" "IPR033631,Ras association domain-containing protein 7;IPR000159,Ras-associating (RA) domain;IPR029071,Ubiquitin-like domain superfamily;IPR033593,N-terminal RASSF family" "ENOG410XPWB,-;KOG1574,Predicted cell growth/differentiation regulator, contains RA domain" "GO:0005815,cellular_component,microtubule organizing center;GO:0070507,biological_process,regulation of microtubule cytoskeleton organization;GO:0007165,biological_process,signal transduction" - SMPD1 2.020357556 2.067410665 2.364846381 1.60857667 1.408506273 1.145477678 0.76404359 2.321691385 7.86693168 0.027065697 0.742896758 "Q59EN6,Sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 variant" "NP_000534.3,sphingomyelin phosphodiesterase isoform 1 precursor;NP_001305017.1,sphingomyelin phosphodiesterase isoform 4;NP_001007594.2,sphingomyelin phosphodiesterase isoform 2 precursor" "PF00149,Calcineurin-like phosphoesterase" "IPR008139,Saposin B type domain;IPR029052,Metallo-dependent phosphatase-like;IPR004843,Calcineurin-like phosphoesterase domain, ApaH type;IPR011001,Saposin-like;IPR011160,Sphingomyelin phosphodiesterase" "KOG3770,Acid sphingomyelinase and PHM5 phosphate metabolism protein;ENOG410YYPB,-" "GO:0016787,molecular_function,hydrolase activity;GO:0004767,molecular_function,sphingomyelin phosphodiesterase activity;GO:0046872,molecular_function,metal ion binding;GO:0006685,biological_process,sphingomyelin catabolic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane" "K12350,ko00600,Sphingolipid metabolism;K12350,ko04142,Lysosome;K12350,ko04071,Sphingolipid signaling pathway" E2F8 0.907840405 0.700427968 0.499816566 1.227329928 0.880566581 3.136597593 -1.266048518 2.348634683 5.7654593 0.049320716 0.742896758 "H2Q3A5,Uncharacterized protein" "XP_001173623.1,-;XP_508325.2,transcription factor E2F8" "PF02319,2F/DP family winged-helix DNA-binding domain" "IPR003316,E2F/DP family, winged-helix DNA-binding domain;IPR036390,Winged helix DNA-binding domain superfamily;IPR015633,E2F Family;IPR036388,Winged helix-like DNA-binding domain superfamily" "ENOG4111IGY,-;KOG2578,Transcription factor E2F/dimerization partner (TDP)-like proteins" "GO:0032877,biological_process,positive regulation of DNA endoreduplication;GO:0001078,molecular_function,transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0060707,biological_process,trophoblast giant cell differentiation;GO:0032466,biological_process,negative regulation of cytokinesis;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003714,molecular_function,transcription corepressor activity;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0001890,biological_process,placenta development;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0005829,cellular_component,cytosol;GO:0001047,molecular_function,core promoter binding;GO:0042802,molecular_function,identical protein binding;GO:0003677,molecular_function,DNA binding;GO:0033301,biological_process,cell cycle comprising mitosis without cytokinesis;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0002040,biological_process,sprouting angiogenesis;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0070365,biological_process,hepatocyte differentiation;GO:0005667,cellular_component,transcription factor complex;GO:0005730,cellular_component,nucleolus;GO:0008283,biological_process,cell proliferation;GO:0060718,biological_process,chorionic trophoblast cell differentiation" - LIN7C 1.449069978 1.324772792 0.59903052 1.989205883 1.79827737 2.010991577 -0.729605674 2.820894591 6.194089845 0.043161849 0.742896758 "G3RYG3,Lin-7 homolog C, crumbs cell polarity complex component" "XP_004050894.1,-" "PF02828,L27 domain;PF00595,PDZ domain (Also known as DHR or GLGF)" "IPR014775,L27 domain, C-terminal;IPR036034,PDZ superfamily;IPR001478,PDZ domain;IPR036892,L27 domain superfamily;IPR004172,L27 domain;IPR017365,Protein lin-7" - "GO:0005911,cellular_component,cell-cell junction;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0006887,biological_process,exocytosis;GO:0007269,biological_process,neurotransmitter secretion;GO:0015031,biological_process,protein transport;GO:0098793,cellular_component,presynapse;GO:0030054,cellular_component,cell junction;GO:0019904,molecular_function,protein domain specific binding;GO:0005737,cellular_component,cytoplasm;GO:0016323,cellular_component,basolateral plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0002011,biological_process,morphogenesis of an epithelial sheet;GO:0016020,cellular_component,membrane;GO:0045202,cellular_component,synapse;GO:0097025,cellular_component,MPP7-DLG1-LIN7 complex;GO:0097016,molecular_function,L27 domain binding" - MDK 1.190610367 1.247696651 2.860484153 0.884695391 0.85598109 0.877184833 1.203609803 1.635310774 5.926569978 0.047025036 0.742896758 "E9PLM6,Midkine" - "PF05196,PTN/MK heparin-binding protein family, N-terminal domain;PF01091,PTN/MK heparin-binding protein family, C-terminal domain" "IPR020089,Pleiotrophin/Midkine, N-terminal domain;IPR020092,Pleiotrophin/Midkine heparin-binding growth factor, conserved site;IPR020091,Pleiotrophin/Midkine disulphide-rich domain superfamily;IPR037122,Pleiotrophin/Midkine, N-terminal domain superfamily;IPR000762,Midkine heparin-binding growth factor;IPR020090,Pleiotrophin/Midkine, C-terminal domain;IPR038130,Pleiotrophin/Midkine, C-terminal domain superfamily" "ENOG4111ZWP,-;ENOG410J0E8,-" "GO:0008083,molecular_function,growth factor activity;GO:0010469,biological_process,regulation of signaling receptor activity" - FAM111B 2.042565372 1.861855382 1.951319658 3.744841126 2.816379832 11.35756338 -1.53106066 3.941755909 7.095666841 0.033955187 0.742896758 "H2Q3Q6,Family with sequence similarity 111 member B" "XP_003318041.1,protein FAM111B isoform X1" "PF13365,Trypsin-like peptidase domain" "IPR009003,Peptidase S1, PA clan" "ENOG4112AWX,-;ENOG410IHAZ,-" - - BEST1 166.3757327 179.9525075 316.0521412 126.1868662 121.5426399 110.4363421 1.05909715 10.62932713 6.847301102 0.036286609 0.742896758 "F6S416,Bestrophin" - "PF01062,Bestrophin, RFP-TM, chloride channel" "IPR000615,Bestrophin;IPR021134,Bestrophin/UPF0187;IPR033041,Bestrophin-1" "KOG3547,Bestrophin (Best vitelliform macular dystrophy-associated protein);ENOG410XS3J,-" "GO:0050908,biological_process,detection of light stimulus involved in visual perception;GO:0051924,biological_process,regulation of calcium ion transport;GO:1902476,biological_process,chloride transmembrane transport;GO:0006821,biological_process,chloride transport;GO:0034707,cellular_component,chloride channel complex;GO:0042802,molecular_function,identical protein binding;GO:0006811,biological_process,ion transport;GO:0005254,molecular_function,chloride channel activity;GO:0016323,cellular_component,basolateral plasma membrane;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0030321,biological_process,transepithelial chloride transport;GO:0007601,biological_process,visual perception;GO:0016021,cellular_component,integral component of membrane" - FTH1 953.7192474 1061.120089 1726.078172 734.5502399 701.0912929 687.6509496 0.98162471 11.00945321 6.518249135 0.03971171 0.742896758 "G3RMF9,Ferritin" "XP_004051373.1,-" "PF00210,erritin-like domain" "IPR008331,Ferritin/DPS protein domain;IPR012347,Ferritin-like;IPR009040,Ferritin-like diiron domain;IPR001519,Ferritin;IPR009078,Ferritin-like superfamily;IPR014034,Ferritin, conserved site" - "GO:0005623,cellular_component,cell;GO:0008199,molecular_function,ferric iron binding;GO:0046872,molecular_function,metal ion binding;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0006826,biological_process,iron ion transport" - RARRES3 1.545515173 1.66983882 1.668803579 1.265512043 0.635830589 0.907190966 0.912350984 0.801545977 6.579796442 0.038341819 0.742896758 "H2R233,Retinoic acid receptor responder" "XP_508513.2,retinoic acid receptor responder protein 3" "PF04970,Lecithin retinol acyltransferase" "IPR033210,Retinoic acid receptor responder protein 3;IPR007053,LRAT-like domain" "ENOG410J5BU,-;ENOG410Y257,-" "GO:0006644,biological_process,phospholipid metabolic process;GO:0004623,molecular_function,phospholipase A2 activity;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - DNAJC4 2.386840822 2.513484236 2.211514696 1.735633148 1.785758912 0.944600069 0.789580104 2.460158294 7.404501138 0.030805766 0.742896758 "J3KNJ8,DnaJ homolog subfamily C member 4" "NP_001294909.1,dnaJ homolog subfamily C member 4 isoform 1" "PF00226,naJ domain" "IPR036869,Chaperone J-domain superfamily;IPR001623,DnaJ domain" "COG0484,DnaJ-class molecular chaperone with C-terminal Zn finger domain;ENOG410KDCY,-" "GO:0005739,cellular_component,mitochondrion;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - VEGFB 12.25395676 11.66027031 23.35827905 9.808265644 9.346134927 7.627450255 0.999679564 4.318287249 5.771992567 0.049224773 0.742896758 "H2R5B3,Vascular endothelial growth factor B" "XP_003313105.1,-" "PF00341,PDGF/VEGF domain" "IPR023581,Platelet-derived growth factor, conserved site;IPR000072,PDGF/VEGF domain;IPR029034,Cystine-knot cytokine" "ENOG410II0A,-;ENOG410ZN1X,-" "GO:0008083,molecular_function,growth factor activity;GO:0050930,biological_process,induction of positive chemotaxis;GO:0043184,molecular_function,vascular endothelial growth factor receptor 2 binding;GO:0060976,biological_process,coronary vasculature development;GO:0016020,cellular_component,membrane;GO:0045766,biological_process,positive regulation of angiogenesis;GO:0046982,molecular_function,protein heterodimerization activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0060754,biological_process,positive regulation of mast cell chemotaxis;GO:0048010,biological_process,vascular endothelial growth factor receptor signaling pathway;GO:0006493,biological_process,protein O-linked glycosylation;GO:0060048,biological_process,cardiac muscle contraction;GO:0001525,biological_process,angiogenesis;GO:0001666,biological_process,response to hypoxia;GO:0001938,biological_process,positive regulation of endothelial cell proliferation;GO:0043183,molecular_function,vascular endothelial growth factor receptor 1 binding;GO:0005622,cellular_component,intracellular;GO:0007507,biological_process,heart development;GO:0042803,molecular_function,protein homodimerization activity;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space" - CDC42EP2 0.923701954 1.201188534 1.140864702 0.631649009 0.627500199 0.550254371 0.97237462 0.974444507 11.04880336 0.013191303 0.742896758 "H2Q427,CDC42 effector protein" "XP_508550.2,cdc42 effector protein 2;XP_016776724.1,-;XP_009421736.1,-" "PF14957,Cdc42 effector;PF00786,P21-Rho-binding domain" "IPR017363,Cdc42 effector protein 2;IPR000095,CRIB domain;IPR029273,Cdc42 effector" "ENOG4111X3X,-;ENOG410IZS0,-" "GO:0030036,biological_process,actin cytoskeleton organization;GO:0017049,molecular_function,GTP-Rho binding;GO:0008360,biological_process,regulation of cell shape;GO:0005096,molecular_function,GTPase activator activity;GO:0030838,biological_process,positive regulation of actin filament polymerization;GO:0016020,cellular_component,membrane;GO:0005737,cellular_component,cytoplasm;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0007266,biological_process,Rho protein signal transduction;GO:0045335,cellular_component,phagocytic vesicle;GO:0043547,biological_process,positive regulation of GTPase activity;GO:0005886,cellular_component,plasma membrane;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0031274,biological_process,positive regulation of pseudopodium assembly;GO:0005829,cellular_component,cytosol;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0001515,molecular_function,opioid peptide activity" - RHOD 1.162609847 1.155179697 1.207349108 0.850598709 0.495318702 0.50161675 1.052138354 0.264661668 8.36425071 0.023928518 0.742896758 "G3SGR1,Ras homolog family member D" - "PF00071,Ras family" "IPR001806,Small GTPase superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase" - "GO:0006605,biological_process,protein targeting;GO:0019901,molecular_function,protein kinase binding;GO:0005525,molecular_function,GTP binding;GO:0045785,biological_process,positive regulation of cell adhesion;GO:2000249,biological_process,regulation of actin cytoskeleton reorganization;GO:0030032,biological_process,lamellipodium assembly;GO:0051893,biological_process,regulation of focal adhesion assembly;GO:0003924,molecular_function,GTPase activity;GO:0051017,biological_process,actin filament bundle assembly;GO:0005622,cellular_component,intracellular;GO:0048041,biological_process,focal adhesion assembly;GO:0000166,molecular_function,nucleotide binding;GO:0030335,biological_process,positive regulation of cell migration" "K07530,ko04360,Axon guidance" TMEM134 2.012727345 2.146876813 2.625600262 1.283425096 1.778843132 1.338508181 0.762709255 3.49441378 6.868267655 0.035816067 0.742896758 "H2Q489,Transmembrane protein 134" "XP_003313227.1,-" "PF05915,ukaryotic protein of unknown function (DUF872)" "IPR008590,Protein of unknown function DUF872, transmembrane" "KOG4753,Predicted membrane protein;ENOG4111TWA,-" "GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - ALKBH8 2.719894688 2.670419722 1.486994692 3.581915336 3.457392694 3.807230896 -0.591045764 3.716761408 6.273499025 0.041583908 0.742896758 "G3RHK5,AlkB homolog 8, tRNA methyltransferase" "XP_004052117.1,alkylated DNA repair protein alkB homolog 8" "PF13649,Methyltransferase domain;PF13489,Methyltransferase domain;PF13532,2OG-Fe(II) oxygenase superfamily;PF09004,omain of unknown function (DUF1891);PF05148,Hypothetical methyltransferase;PF08241,Methyltransferase domain" "IPR032863,Alkylated DNA repair protein alkB homologue 8;IPR029063,S-adenosyl-L-methionine-dependent methyltransferase;IPR013216,Methyltransferase type 11;IPR005123,Oxoglutarate/iron-dependent dioxygenase;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR027450,Alpha-ketoglutarate-dependent dioxygenase AlkB-like;IPR015095,Alkylated DNA repair protein AlkB, homologue 8, N-terminal;IPR035979,RNA-binding domain superfamily;IPR034256,ALKBH8, RNA recognition motif" - "GO:0008152,biological_process,metabolic process;GO:0003676,molecular_function,nucleic acid binding;GO:0030488,biological_process,tRNA methylation;GO:0016491,molecular_function,oxidoreductase activity;GO:0016706,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0008168,molecular_function,methyltransferase activity;GO:0016300,molecular_function,tRNA (uracil) methyltransferase activity;GO:0055114,biological_process,oxidation-reduction process;GO:0002098,biological_process,tRNA wobble uridine modification" - C11orf1 2.784761596 3.140932203 3.806635174 2.387382569 2.096474225 2.117753454 0.696763186 3.420510899 6.089141403 0.044352548 0.742896758 "E9PMC1,UPF0686 protein C11orf1" - "PF06608,Protein of unknown function (DUF1143)" "IPR009524,Uncharacterised protein family UPF0686" "ENOG410IVWW,-;ENOG411205M,-" "GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" - CRYAB 0.684791566 0.707411924 0.503393745 0.413758051 0.225293279 0.119511289 1.429822467 0.485108818 9.60910885 0.018563137 0.742896758 "V9HW27,Alpha-crystallin B chain" "NP_001276737.1,-;XP_011540910.1,-;NP_001876.1,alpha-crystallin B chain isoform 1;NP_001276736.1,-" "PF00011,Hsp20/alpha crystallin family;PF00525,Alpha crystallin A chain, N terminal" "IPR001436,Alpha crystallin/Heat shock protein;IPR003090,Alpha-crystallin, N-terminal;IPR008978,HSP20-like chaperone;IPR002068,Alpha crystallin/Hsp20 domain;IPR037882,Alpha-crystallin B chain, ACD domain;IPR031107,Small heat shock protein HSP20" "ENOG410YERS,-;KOG3591,Alpha crystallins" "GO:0031109,biological_process,microtubule polymerization or depolymerization;GO:0005886,cellular_component,plasma membrane;GO:0008017,molecular_function,microtubule binding;GO:0032432,cellular_component,actin filament bundle;GO:0045202,cellular_component,synapse;GO:0007021,biological_process,tubulin complex assembly;GO:0005634,cellular_component,nucleus;GO:0042542,biological_process,response to hydrogen peroxide;GO:0015630,cellular_component,microtubule cytoskeleton;GO:0005794,cellular_component,Golgi apparatus;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0097512,cellular_component,cardiac myofibril;GO:0031430,cellular_component,M band;GO:0006457,biological_process,protein folding;GO:0010629,biological_process,negative regulation of gene expression;GO:0043204,cellular_component,perikaryon;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0032355,biological_process,response to estradiol;GO:0007517,biological_process,muscle organ development;GO:0005212,molecular_function,structural constituent of eye lens;GO:0043292,cellular_component,contractile fiber;GO:0060561,biological_process,apoptotic process involved in morphogenesis;GO:0005515,molecular_function,protein binding;GO:0030424,cellular_component,axon;GO:0009986,cellular_component,cell surface;GO:0030308,biological_process,negative regulation of cell growth;GO:2000378,biological_process,negative regulation of reactive oxygen species metabolic process;GO:0043197,cellular_component,dendritic spine;GO:0097060,cellular_component,synaptic membrane;GO:0001666,biological_process,response to hypoxia;GO:0043209,cellular_component,myelin sheath;GO:0043010,biological_process,camera-type eye development;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0051403,biological_process,stress-activated MAPK cascade;GO:0031674,cellular_component,I band;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007568,biological_process,aging;GO:0014069,cellular_component,postsynaptic density;GO:0002088,biological_process,lens development in camera-type eye;GO:0030018,cellular_component,Z disc" "K09542,ko04213,Longevity regulating pathway - multiple species;K09542,ko04141,Protein processing in endoplasmic reticulum" TRIM29 0.804193832 0.677075079 0.347158893 1.281211878 1.231994991 0.842795528 -0.809301273 3.114375234 7.451744846 0.030731818 0.742896758 "A0A024R3J1,Tripartite motif-containing 29, isoform CRA_a" "NP_036233.2,tripartite motif-containing protein 29 isoform 1" "PF00643,B-box zinc finger" "IPR000315,B-box-type zinc finger" "ENOG410YEFV,-;ENOG410IK88,-" "GO:1900181,biological_process,negative regulation of protein localization to nucleus;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005737,cellular_component,cytoplasm;GO:0005622,cellular_component,intracellular;GO:0002039,molecular_function,p53 binding;GO:0008270,molecular_function,zinc ion binding" - ENO2 13.11456306 17.49398359 8.32635656 8.238526131 8.143081115 5.029014658 0.939910051 5.418984712 10.21628148 0.016135105 0.742896758 "K7DNP5,Enolase 2" "XP_016778361.1,-;XP_016778359.1,-;XP_016778360.1,-" "PF00113,nolase, C-terminal TIM barrel domain;PF03952,nolase, N-terminal domain" "IPR020811,Enolase, N-terminal;IPR029017,Enolase-like, N-terminal;IPR020809,Enolase, conserved site;IPR000941,Enolase;IPR034390,Enolase-like superfamily;IPR020810,Enolase, C-terminal TIM barrel domain;IPR036849,Enolase-like, C-terminal domain superfamily" - "GO:0043209,cellular_component,myelin sheath;GO:0043025,cellular_component,neuronal cell body;GO:0004634,molecular_function,phosphopyruvate hydratase activity;GO:0006096,biological_process,glycolytic process;GO:0005737,cellular_component,cytoplasm;GO:0005622,cellular_component,intracellular;GO:0046872,molecular_function,metal ion binding;GO:0043204,cellular_component,perikaryon;GO:0005886,cellular_component,plasma membrane;GO:0000287,molecular_function,magnesium ion binding;GO:0016020,cellular_component,membrane;GO:0000015,cellular_component,phosphopyruvate hydratase complex;GO:0005829,cellular_component,cytosol;GO:0001917,cellular_component,photoreceptor inner segment" "K01689,ko00680,Methane metabolism;K01689,ko00010,Glycolysis / Gluconeogenesis;K01689,ko03018,RNA degradation;K01689,ko04066,HIF-1 signaling pathway;K01689,ko01200,Carbon metabolism;K01689,ko01230,Biosynthesis of amino acids" CLEC2B 2.168079815 3.038032561 0.877778146 1.167011612 0.939284233 0.678667144 1.177322096 1.957204413 8.238925086 0.025435367 0.742896758 "H2Q5E6,C-type lectin domain family 2, member B" "XP_528730.2,-" "PF00059,Lectin C-type domain" "IPR016187,C-type lectin fold;IPR033992,Natural killer cell receptor-like, C-type lectin-like domain;IPR016186,C-type lectin-like/link domain superfamily;IPR001304,C-type lectin-like" "ENOG410XPJ1,-;KOG4297,C-type lectin" "GO:0030246,molecular_function,carbohydrate binding;GO:0042802,molecular_function,identical protein binding;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - GRIN2B 0.147878725 0.199983905 0.045380807 0.254058744 0.248531814 0.373542787 -1.134659351 2.686444088 5.822080192 0.048497361 0.742896758 "H2NGN9,Glutamate ionotropic receptor NMDA type subunit 2B" "XP_002823014.1,-" "PF10565,N-methyl D-aspartate receptor 2B3 C-terminus;PF00060,Ligand-gated ion channel;PF01094,Receptor family ligand binding region;PF10613,Ligated ion channel L-glutamate- and glycine-binding site" "IPR001508,Ionotropic glutamate receptor, metazoa;IPR019594,Ionotropic glutamate receptor, L-glutamate and glycine-binding domain;IPR018884,Glutamate [NMDA] receptor, epsilon subunit, C-terminal;IPR028082,Periplasmic binding protein-like I;IPR001320,Ionotropic glutamate receptor;IPR001828,Receptor, ligand binding region" "KOG1053,Glutamate-gated NMDA-type ion channel receptor subunit GRIN2A and related subunits;ENOG410XNUR,-" "GO:0097553,biological_process,calcium ion transmembrane import into cytosol;GO:0004872,-,-;GO:0005886,cellular_component,plasma membrane;GO:0045471,biological_process,response to ethanol;GO:0004972,molecular_function,NMDA glutamate receptor activity;GO:0045202,cellular_component,synapse;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0030054,cellular_component,cell junction;GO:0004970,molecular_function,ionotropic glutamate receptor activity;GO:0006811,biological_process,ion transport;GO:0016020,cellular_component,membrane;GO:0005216,molecular_function,ion channel activity;GO:0045211,cellular_component,postsynaptic membrane;GO:0019722,biological_process,calcium-mediated signaling;GO:0005234,molecular_function,extracellularly glutamate-gated ion channel activity;GO:0017146,cellular_component,NMDA selective glutamate receptor complex;GO:0022849,molecular_function,glutamate-gated calcium ion channel activity;GO:0005622,cellular_component,intracellular;GO:0035235,biological_process,ionotropic glutamate receptor signaling pathway;GO:0016594,molecular_function,glycine binding;GO:0060079,biological_process,excitatory postsynaptic potential" "K05210,ko04713,Circadian entrainment;K05210,ko04015,Rap1 signaling pathway;K05210,ko05034,Alcoholism;K05210,ko04014,Ras signaling pathway;K05210,ko05322,Systemic lupus erythematosus;K05210,ko04728,Dopaminergic synapse;K05210,ko04724,Glutamatergic synapse;K05210,ko04024,cAMP signaling pathway;K05210,ko05010,Alzheimer's disease;K05210,ko04080,Neuroactive ligand-receptor interaction;K05210,ko05014,Amyotrophic lateral sclerosis (ALS);K05210,ko05031,Amphetamine addiction;K05210,ko05033,Nicotine addiction;K05210,ko04720,Long-term potentiation;K05210,ko05030,Cocaine addiction;K05210,ko05016,Huntington's disease" PYROXD1 2.030662855 1.974193906 1.523208914 3.529262398 3.283378995 2.794690599 -0.701612051 3.837460095 12.0434542 0.010842623 0.742896758 "H2Q5K8,Pyridine nucleotide-disulfide oxidoreductase domain 1" "XP_520786.2,pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1" "PF07992,Pyridine nucleotide-disulphide oxidoreductase" "IPR023753,FAD/NAD(P)-binding domain;IPR036188,FAD/NAD(P)-binding domain superfamily" "KOG2755,Oxidoreductase;ENOG410XZAZ,-" "GO:0055114,biological_process,oxidation-reduction process;GO:0016491,molecular_function,oxidoreductase activity;GO:0030017,cellular_component,sarcomere;GO:0005634,cellular_component,nucleus;GO:0034599,biological_process,cellular response to oxidative stress" - ARNTL2 1.454223598 1.428892293 0.994806852 1.900437853 1.961803953 2.369110634 -0.604998035 3.547221175 7.258796936 0.03167482 0.742896758 "H2Q5N1,Uncharacterized protein" - "PF14598,PAS domain;PF00010,Helix-loop-helix DNA-binding domain;PF00989,PAS fold" "IPR000014,PAS domain;IPR001067,Nuclear translocator;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR035965,PAS domain superfamily;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR013767,PAS fold" "ENOG410XRJI,-;KOG3561,Aryl-hydrocarbon receptor nuclear translocator" "GO:0046983,molecular_function,protein dimerization activity;GO:0005667,cellular_component,transcription factor complex;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus" - GXYLT1 3.051564386 2.710582279 1.807202756 3.990794001 3.597617931 4.513119374 -0.604521337 4.603782981 6.815965598 0.035695432 0.742896758 "H2RCX7,Glucoside xylosyltransferase 1" "XP_001167787.1,glucoside xylosyltransferase 1 isoform X1" "PF01501,lycosyl transferase family 8" "IPR029044,Nucleotide-diphospho-sugar transferases;IPR002495,Glycosyl transferase, family 8" "KOG3765,Predicted glycosyltransferase;ENOG410XRNY,-" "GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0035252,molecular_function,UDP-xylosyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0016266,biological_process,O-glycan processing" "K13676,ko00514,Other types of O-glycan biosynthesis" PUS7L 1.598207118 1.431424582 0.624751632 2.210221492 2.144634353 2.219897501 -0.798149325 4.550914738 7.17811107 0.033180583 0.742896758 "K7B4W4,Pseudouridylate synthase 7 homolog-like" - "PF01142,tRNA pseudouridine synthase D (TruD)" "IPR001656,Pseudouridine synthase, TruD;IPR020103,Pseudouridine synthase, catalytic domain superfamily;IPR011760,Pseudouridine synthase, TruD, insertion domain" "COG0585,Uncharacterized conserved protein;KOG2339,Uncharacterized conserved protein" "GO:0003723,molecular_function,RNA binding;GO:0001522,biological_process,pseudouridine synthesis;GO:0009451,biological_process,RNA modification;GO:0009982,molecular_function,pseudouridine synthase activity" - SENP1 2.215920761 2.008945061 1.176923114 2.884283387 2.496899859 3.430437564 -0.643422983 3.893030772 6.048105363 0.04450622 0.742896758 "K7D7C5,SUMO1/sentrin specific peptidase 1" "XP_016779031.1,-;XP_016779030.1,sentrin-specific protease 1 isoform X4" "PF02902,Ulp1 protease family, C-terminal catalytic domain" "IPR003653,Ulp1 protease family, C-terminal catalytic domain" "COG5160,Protease, Ulp1 family;KOG0778,Protease, Ulp1 family" "GO:0006508,biological_process,proteolysis;GO:0070140,molecular_function,SUMO-specific isopeptidase activity;GO:0032435,biological_process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0016926,biological_process,protein desumoylation;GO:0008234,molecular_function,cysteine-type peptidase activity;GO:0010724,biological_process,regulation of definitive erythrocyte differentiation;GO:0031965,cellular_component,nuclear membrane;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0097190,biological_process,apoptotic signaling pathway;GO:0005925,cellular_component,focal adhesion;GO:0005634,cellular_component,nucleus" - CCDC184 2.371311685 2.358322402 2.481255095 1.683892593 1.884134841 1.151010265 0.73895516 2.252531686 7.263690584 0.031642467 0.742896758 "G1SC66,Coiled-coil domain containing 184" "XP_003252266.1,coiled-coil domain-containing protein 184" "PF15726,omain of unknown function (DUF4677)" "IPR031458,Protein of unknown function DUF4677" "ENOG41115RJ,-;ENOG410IWAW,-" "GO:0005737,cellular_component,cytoplasm" - NR4A1 1.88483775 1.712072412 1.522940538 14.96298418 17.1900033 1.966450134 -2.607274756 5.514972106 13.05375346 0.00942387 0.742896758 "F5GXF0,Nuclear receptor subfamily 4 group A member 1" "NP_001189163.1,nuclear receptor subfamily 4 group A member 1 isoform 3" "PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor" "IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR003070,Orphan nuclear receptor;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003071,Orphan nuclear receptor, HMR type;IPR013088,Zinc finger, NHR/GATA-type" "KOG4217,Nuclear receptors of the nerve growth factor-induced protein B type;ENOG410YWNC,-" "GO:0061469,biological_process,regulation of type B pancreatic cell proliferation;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0035259,molecular_function,glucocorticoid receptor binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005634,cellular_component,nucleus;GO:0043401,biological_process,steroid hormone mediated signaling pathway;GO:0045786,biological_process,negative regulation of cell cycle;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0071310,biological_process,cellular response to organic substance;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005829,cellular_component,cytosol;GO:0045444,biological_process,fat cell differentiation;GO:0006915,biological_process,apoptotic process;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0031965,cellular_component,nuclear membrane;GO:0008270,molecular_function,zinc ion binding;GO:0004879,molecular_function,nuclear receptor activity;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0005667,cellular_component,transcription factor complex;GO:0071376,biological_process,cellular response to corticotropin-releasing hormone stimulus;GO:0046872,molecular_function,metal ion binding;GO:0043154,biological_process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0043065,biological_process,positive regulation of apoptotic process;GO:0006351,biological_process,transcription, DNA-templated" - ITGA5 2.742058351 3.329853216 2.158750711 2.003914414 2.259070351 1.190392848 0.692614642 4.112104597 6.219816115 0.042669837 0.742896758 "A0A024RB01,Integrin, alpha 5" - "PF01839,-GAP repeat;PF08441,Integrin alpha" "IPR013517,FG-GAP repeat;IPR018184,Integrin alpha chain, C-terminal cytoplasmic region, conserved site;IPR032695,Integrin domain superfamily;IPR013649,Integrin alpha-2;IPR013519,Integrin alpha beta-propellor;IPR000413,Integrin alpha chain;IPR028994,Integrin alpha, N-terminal" "KOG3637,Vitronectin receptor, alpha subunit;ENOG410XPVZ,-" "GO:0008305,cellular_component,integrin complex;GO:0007155,biological_process,cell adhesion;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - NAB2 9.213696829 9.603450652 8.609559776 6.523964933 6.121958144 5.044438494 0.743874371 4.516409537 12.13891069 0.010646807 0.742896758 "H2Q6A3,NGFI-A binding protein 2" "XP_509154.2,-" "PF04904,NAB conserved region 1 (NCD1);PF04905,NAB conserved region 2 (NCD2)" "IPR006989,NAB co-repressor, domain;IPR038398,NAB co-repressor domain 2 superfamily;IPR006988,Nab, N-terminal" "ENOG410YKFH,-;KOG3835,Transcriptional corepressor NAB1" "GO:0045682,biological_process,regulation of epidermis development;GO:0042802,molecular_function,identical protein binding;GO:0042552,biological_process,myelination;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0008134,molecular_function,transcription factor binding;GO:0016480,biological_process,negative regulation of transcription by RNA polymerase III;GO:0014037,biological_process,Schwann cell differentiation;GO:0005634,cellular_component,nucleus;GO:0001958,biological_process,endochondral ossification" - LRRIQ1 0.602139044 0.558740345 0.224832452 0.755134506 0.971964675 0.836347825 -0.837227938 2.294391676 6.541584759 0.039455102 0.742896758 "A0A140VJN5,Testicular tissue protein Li 111" "NP_001073379.1,leucine-rich repeat and IQ domain-containing protein 1;XP_016875508.1,-" "PF00612,IQ calmodulin-binding motif" "IPR001611,Leucine-rich repeat;IPR000048,IQ motif, EF-hand binding site;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase" - - - GAS2L3 0.703870547 0.641428755 0.499995098 1.006707224 0.795904813 1.306608713 -0.672678699 2.490821646 5.923594037 0.046216069 0.742896758 "A0A024RBF4,Growth arrest-specific 2 like 3, isoform CRA_a" "NP_001290059.1,-;NP_777602.1,GAS2-like protein 3 isoform a;XP_005268861.1,-;XP_011536523.1,-;XP_011536522.1,-;XP_016874695.1,-;XP_011536521.1,-" "PF02187,rowth-Arrest-Specific Protein 2 Domain;PF00307,Calponin homology (CH) domain" "IPR003108,GAR domain;IPR036534,GAR domain superfamily;IPR029932,GAS2-like protein 3;IPR036872,CH domain superfamily;IPR001715,Calponin homology domain" "ENOG410IQBS,-;ENOG410Z7C5,-" "GO:0005856,cellular_component,cytoskeleton;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0008017,molecular_function,microtubule binding;GO:0003779,molecular_function,actin binding;GO:0030036,biological_process,actin cytoskeleton organization" - NT5DC3 0.778862653 0.769646586 0.432122669 1.007497535 0.99921263 1.166634412 -0.61423641 2.893079534 6.296826417 0.041305499 0.742896758 "H2NIF9,5'-nucleotidase domain containing 3" "XP_009246440.1,-" "PF05761,5' nucleotidase family" "IPR008380,HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR016695,Purine 5'-nucleotidase" "KOG2470,Similar to IMP-GMP specific 5'-nucleotidase;ENOG410XT8W,-" "GO:0043235,cellular_component,receptor complex;GO:0046872,molecular_function,metal ion binding" - EID3 3.325830756 3.315198892 1.779948566 4.686088283 5.144798039 4.866144084 -0.735622123 2.484850596 9.074624377 0.020221622 0.742896758 "A0A140VJI9,Testis tissue sperm-binding protein Li 96mP" "NP_001008395.1,EP300-interacting inhibitor of differentiation 3" "PF15412,Binding domain of Nse4/EID3 to Nse3-MAGE;PF08743,Nse4 C-terminal" "IPR014854,Non-structural maintenance of chromosome element 4, C-terminal;IPR029225,Nse4/EID protein, Nse3/MAGE-binding domain;IPR027786,Nse4/EID family" - "GO:0006281,biological_process,DNA repair;GO:0030915,cellular_component,Smc5-Smc6 complex;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus" - P2RX4 2.145894186 2.244385913 1.582071312 1.417707954 1.640640755 1.049927693 0.635505236 3.780193965 7.636573805 0.028701359 0.742896758 "A0A1D5R6U8,p2X purinoceptor" - - "IPR003047,P2X4 purinoceptor;IPR027309,P2X purinoreceptor extracellular domain superfamily;IPR001429,P2X purinoreceptor" - "GO:0005216,molecular_function,ion channel activity;GO:0004931,molecular_function,extracellularly ATP-gated cation channel activity;GO:0098655,biological_process,cation transmembrane transport;GO:0033198,biological_process,response to ATP;GO:0005524,molecular_function,ATP binding;GO:0006811,biological_process,ion transport;GO:0035590,biological_process,purinergic nucleotide receptor signaling pathway;GO:0098794,cellular_component,postsynapse;GO:0016020,cellular_component,membrane;GO:0001614,molecular_function,purinergic nucleotide receptor activity;GO:0060079,biological_process,excitatory postsynaptic potential;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane" - SCARB1 8.281088736 9.494760365 6.552257862 6.702941011 6.29514174 4.063468736 0.61055085 5.738266308 5.883235116 0.046630027 0.742896758 "A0A0S2Z3N2,Scavenger receptor class B member 1 isoform 1" - "PF01130,CD36 family" "IPR005428,CD36/scavenger receptor class B member 1;IPR002159,CD36 family" - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - XPO4 1.187232921 1.098151295 0.497368485 1.574158926 1.483715379 2.018026365 -0.820642249 3.759104057 6.89705531 0.035803049 0.742896758 "H2Q795,Exportin 4" - "PF08767,CRM1 C terminal" "IPR011989,Armadillo-like helical;IPR016024,Armadillo-type fold" "KOG4541,Nuclear transport receptor exportin 4 (importin beta superfamily);ENOG410XNNN,-" "GO:0005643,cellular_component,nuclear pore;GO:0005737,cellular_component,cytoplasm;GO:0006611,biological_process,protein export from nucleus;GO:0008536,molecular_function,Ran GTPase binding;GO:0005049,molecular_function,nuclear export signal receptor activity;GO:0005829,cellular_component,cytosol;GO:0046827,biological_process,positive regulation of protein export from nucleus;GO:0005654,cellular_component,nucleoplasm" - BRCA2 0.332867418 0.349757643 0.27096596 0.840196958 0.652090926 1.443977888 -1.544251637 2.986626772 18.23403087 0.004189139 0.742896758 "K7C640,Breast cancer 2, early onset" - "PF00634,BRCA2 repeat;PF09169,BRCA2, helical;PF09103,BRCA2, oligonucleotide/oligosaccharide-binding, domain 1;PF09104,BRCA2, oligonucleotide/oligosaccharide-binding, domain 3;PF09121,Tower" "IPR015188,BRCA2, OB3;IPR002093,BRCA2 repeat;IPR015252,Breast cancer type 2 susceptibility protein, helical domain;IPR015205,Tower domain;IPR015187,BRCA2, OB1;IPR012340,Nucleic acid-binding, OB-fold;IPR036315,BRCA2 helical domain superfamily;IPR015525,Breast cancer type 2 susceptibility protein" "KOG4751,DNA recombinational repair protein BRCA2;ENOG410Y06W,-" "GO:0006281,biological_process,DNA repair;GO:0000724,biological_process,double-strand break repair via homologous recombination" - RB1 1.888294587 1.906130181 0.978324694 2.693846005 2.174496474 2.927844958 -0.649006476 3.673818373 5.774180665 0.048415543 0.742896758 "A0A024RDV3,Retinoblastoma 1" "NP_000312.2,retinoblastoma-associated protein" "PF01857,Retinoblastoma-associated protein B domain;PF11934,omain of unknown function (DUF3452);PF01858,Retinoblastoma-associated protein A domain;PF08934,Rb C-terminal domain" "IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR033057,Retinoblastoma-associated protein;IPR002720,Retinoblastoma-associated protein, A-box;IPR015030,Retinoblastoma-associated protein, C-terminal;IPR002719,Retinoblastoma-associated protein, B-box;IPR028309,Retinoblastoma protein family;IPR024599,Retinoblastoma-associated protein, N-terminal" "ENOG410XQF7,-;KOG1010,Rb (Retinoblastoma tumor suppressor)-related protein" "GO:0048565,biological_process,digestive tract development;GO:0048667,biological_process,cell morphogenesis involved in neuron differentiation;GO:2000134,biological_process,negative regulation of G1/S transition of mitotic cell cycle;GO:0071466,biological_process,cellular response to xenobiotic stimulus;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0008134,molecular_function,transcription factor binding;GO:0051301,biological_process,cell division;GO:0005634,cellular_component,nucleus;GO:0030182,biological_process,neuron differentiation;GO:0001558,biological_process,regulation of cell growth;GO:0045786,biological_process,negative regulation of cell cycle;GO:0097284,biological_process,hepatocyte apoptotic process;GO:0045930,biological_process,negative regulation of mitotic cell cycle;GO:0043353,biological_process,enucleate erythrocyte differentiation;GO:0051146,biological_process,striated muscle cell differentiation;GO:0000082,biological_process,G1/S transition of mitotic cell cycle;GO:0071930,biological_process,negative regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0034349,biological_process,glial cell apoptotic process;GO:0045651,biological_process,positive regulation of macrophage differentiation;GO:0051402,biological_process,neuron apoptotic process;GO:0006915,biological_process,apoptotic process;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0010629,biological_process,negative regulation of gene expression;GO:0050680,biological_process,negative regulation of epithelial cell proliferation;GO:0001894,biological_process,tissue homeostasis;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0001102,molecular_function,RNA polymerase II activating transcription factor binding;GO:0019899,molecular_function,enzyme binding;GO:0045879,biological_process,negative regulation of smoothened signaling pathway;GO:0005667,cellular_component,transcription factor complex;GO:0007050,biological_process,cell cycle arrest;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005819,cellular_component,spindle;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0051726,biological_process,regulation of cell cycle;GO:0031175,biological_process,neuron projection development;GO:0042551,biological_process,neuron maturation;GO:0035189,cellular_component,Rb-E2F complex" "K06618,ko05166,HTLV-I infection;K06618,ko05220,Chronic myeloid leukemia;K06618,ko05200,Pathways in cancer;K06618,ko05219,Bladder cancer;K06618,ko05169,Epstein-Barr virus infection;K06618,ko01522,Endocrine resistance;K06618,ko05223,Non-small cell lung cancer;K06618,ko05161,Hepatitis B;K06618,ko05212,Pancreatic cancer;K06618,ko05215,Prostate cancer;K06618,ko05218,Melanoma;K06618,ko05214,Glioma;K06618,ko04110,Cell cycle;K06618,ko05203,Viral carcinogenesis;K06618,ko05222,Small cell lung cancer" DIAPH3 2.180403499 2.170363081 2.087036386 3.755180231 2.840627851 6.815244851 -0.966785628 4.586632574 6.317928675 0.0420078 0.742896758 "K7DBA3,Diaphanous homolog 3" "XP_016780837.1,protein diaphanous homolog 3 isoform X2" "PF02181,ormin Homology 2 Domain;PF06345,RF Autoregulatory Domain;PF06371,iaphanous GTPase-binding Domain;PF06367,iaphanous FH3 Domain" "IPR010465,DRF autoregulatory;IPR014768,Rho GTPase-binding/formin homology 3 (GBD/FH3) domain;IPR027654,Formin, protein diaphanous homologue 3;IPR011989,Armadillo-like helical;IPR010473,Formin, GTPase-binding domain;IPR010472,Formin, FH3 domain;IPR016024,Armadillo-type fold;IPR014767,Diaphanous autoregulatory (DAD) domain;IPR015425,Formin, FH2 domain" "ENOG410Y29H,-;KOG1924,RhoA GTPase effector DIA/Diaphanous" "GO:0030036,biological_process,actin cytoskeleton organization;GO:0016043,biological_process,cellular component organization;GO:0017048,molecular_function,Rho GTPase binding;GO:0003779,molecular_function,actin binding;GO:0045296,molecular_function,cadherin binding" - G2E3 0.811256261 0.820667508 0.466701081 1.058106916 1.0329194 1.822898108 -0.842040986 3.201138152 6.549255006 0.039371235 0.742896758 "G3V483,G2/M phase-specific E3 ubiquitin-protein ligase" - "PF00632,HECT-domain (ubiquitin-transferase);PF13771,PHD-like zinc-binding domain" "IPR001965,Zinc finger, PHD-type;IPR011011,Zinc finger, FYVE/PHD-type;IPR000569,HECT domain;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR034732,Extended PHD (ePHD) domain;IPR019786,Zinc finger, PHD-type, conserved site;IPR035983,HECT, E3 ligase catalytic domain" "ENOG410IPTH,-;ENOG410ZNVY,-" "GO:0016567,biological_process,protein ubiquitination;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0005829,cellular_component,cytosol" - RP11-176H8.1 5.643427367 5.0963414 2.52911639 7.320191835 7.670887159 7.420861867 -0.698344665 4.689845828 7.019712992 0.033931547 0.742896758 "F8W1H4,Uncharacterized protein" - - "IPR023509,D-aminoacyl-tRNA deacylase-like superfamily;IPR003732,D-aminoacyl-tRNA deacylase DTD" "COG1490,D-Tyr-tRNAtyr deacylase;KOG3323,D-Tyr-tRNA (Tyr) deacylase" "GO:0051499,molecular_function,D-aminoacyl-tRNA deacylase activity;GO:0002161,molecular_function,aminoacyl-tRNA editing activity;GO:0005737,cellular_component,cytoplasm;GO:0051500,molecular_function,D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0006399,biological_process,tRNA metabolic process;GO:0106074,biological_process,aminoacyl-tRNA metabolism involved in translational fidelity" - EGLN3 3.197611536 3.977675233 0.766563931 1.279394546 1.19589279 0.554317036 1.425625716 3.714989026 6.515227535 0.039745097 0.742896758 "G1QSP2,Egl-9 family hypoxia inducible factor 3" "XP_003263738.1,-" "PF13640,2OG-Fe(II) oxygenase superfamily" "IPR005123,Oxoglutarate/iron-dependent dioxygenase;IPR006620,Prolyl 4-hydroxylase, alpha subunit" "ENOG410ZHZN,-;KOG3710,EGL-Nine (EGLN) protein" "GO:0042127,biological_process,regulation of cell proliferation;GO:0006915,biological_process,apoptotic process;GO:0031418,molecular_function,L-ascorbic acid binding;GO:0018401,biological_process,peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0016705,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0031545,molecular_function,peptidyl-proline 4-dioxygenase activity;GO:0005506,molecular_function,iron ion binding;GO:0016706,molecular_function,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0046872,molecular_function,metal ion binding;GO:0005737,cellular_component,cytoplasm;GO:0016491,molecular_function,oxidoreductase activity;GO:0001666,biological_process,response to hypoxia;GO:0055114,biological_process,oxidation-reduction process;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0018126,biological_process,protein hydroxylation;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus" "K09592,ko04066,HIF-1 signaling pathway;K09592,ko05211,Renal cell carcinoma;K09592,ko05200,Pathways in cancer" GMFB 4.433866358 4.28223399 2.687269208 6.115895362 6.174539972 5.982786357 -0.60409996 5.279976945 8.142829794 0.02526322 0.742896758 "G3V4P8,Glia maturation factor beta" - "PF00241,Cofilin/tropomyosin-type actin-binding protein" "IPR002108,Actin-depolymerising factor homology domain;IPR011171,Glia maturation factor;IPR029006,ADF-H/Gelsolin-like domain superfamily" "KOG1736,Glia maturation factor beta;ENOG4111RK6,-" "GO:0034316,biological_process,negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0071933,molecular_function,Arp2/3 complex binding;GO:0003779,molecular_function,actin binding;GO:0005622,cellular_component,intracellular" - LGALS3 4.294914556 5.448639741 6.895824302 3.765751458 4.01606966 2.940335443 0.785255411 3.493291615 5.875151392 0.047742055 0.742896758 "A0A024R693,Galectin" "NP_002297.2,galectin-3 isoform 1" "PF00337,alactoside-binding lectin" "IPR001079,Galectin, carbohydrate recognition domain;IPR013320,Concanavalin A-like lectin/glucanase domain superfamily;IPR015534,Galectin-3" "ENOG4111EA0,-;KOG3587,Galectin, galactose-binding lectin" "GO:0030246,molecular_function,carbohydrate binding" - EXOC5 3.412097922 3.055879473 1.379101932 4.20943019 4.27608734 5.168632776 -0.752438368 5.466145669 6.008767408 0.045908103 0.742896758 "A0A0A0MSI8,Exocyst complex component 5" - "PF07393,xocyst complex component Sec10" "IPR009976,Exocyst complex component Sec10-like;IPR033960,Exocyst complex component EXOC5/Sec10" "KOG3745,Exocyst subunit - Sec10p;ENOG410XSQQ,-" "GO:0005737,cellular_component,cytoplasm;GO:0048278,biological_process,vesicle docking;GO:0000145,cellular_component,exocyst;GO:0006887,biological_process,exocytosis" - ABCD4 3.910710781 4.147876381 4.123895835 3.084688065 3.338840059 2.385372208 0.590577364 4.956329254 6.17987521 0.042726402 0.742896758 "A0A024R6B9,ATP-binding cassette, sub-family D" "NP_005041.1,ATP-binding cassette sub-family D member 4 isoform a" "PF06472,ABC transporter transmembrane region 2;PF00005,ABC transporter" "IPR003439,ABC transporter-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR011527,ABC transporter type 1, transmembrane domain;IPR036640,ABC transporter type 1, transmembrane domain superfamily;IPR003593,AAA+ ATPase domain;IPR017871,ABC transporter, conserved site" "KOG0060,Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis);COG4178,ABC-type uncharacterized transport system, permease and ATPase components" "GO:0042626,molecular_function,ATPase activity, coupled to transmembrane movement of substances;GO:0055085,biological_process,transmembrane transport;GO:0016887,molecular_function,ATPase activity;GO:0016020,cellular_component,membrane;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane" "K05678,ko02010,ABC transporters;K05678,ko04146,Peroxisome" FOS 5.464825944 6.783570246 0.532540813 66.32277239 82.19682306 2.911528263 -3.535880248 6.388227808 7.568870662 0.03003181 0.742896758 "Q6FG41,FOS protein" "NP_005243.1,proto-oncogene c-Fos" "PF00170,bZIP transcription factor" "IPR029816,c-Fos/v-Fos;IPR000837,AP-1 transcription factor;IPR004827,Basic-leucine zipper domain" "KOG1414,Transcriptional activator FOSB/c-Fos and related bZIP transcription factors;ENOG4111CH5,-" "GO:0046982,molecular_function,protein heterodimerization activity;GO:1901216,biological_process,positive regulation of neuron death;GO:0034097,biological_process,response to cytokine;GO:0035994,biological_process,response to muscle stretch;GO:1902895,biological_process,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0009416,biological_process,response to light stimulus;GO:0008134,molecular_function,transcription factor binding;GO:0001661,biological_process,conditioned taste aversion;GO:0009612,biological_process,response to mechanical stimulus;GO:0030431,biological_process,sleep;GO:0005634,cellular_component,nucleus;GO:0043005,cellular_component,neuron projection;GO:0031668,biological_process,cellular response to extracellular stimulus;GO:0035902,biological_process,response to immobilization stress;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0009629,biological_process,response to gravity;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0045672,biological_process,positive regulation of osteoclast differentiation;GO:0009636,biological_process,response to toxic substance;GO:0032496,biological_process,response to lipopolysaccharide;GO:0003682,molecular_function,chromatin binding;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0014070,biological_process,response to organic cyclic compound;GO:0032870,biological_process,cellular response to hormone stimulus;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0051412,biological_process,response to corticosterone;GO:0009409,biological_process,response to cold;GO:0016020,cellular_component,membrane;GO:0071277,biological_process,cellular response to calcium ion;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0051591,biological_process,response to cAMP;GO:0005654,cellular_component,nucleoplasm;GO:0007565,biological_process,female pregnancy;GO:0005515,molecular_function,protein binding;GO:0032570,biological_process,response to progesterone;GO:0005667,cellular_component,transcription factor complex;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0007399,biological_process,nervous system development;GO:0003690,molecular_function,double-stranded DNA binding;GO:0035914,biological_process,skeletal muscle cell differentiation;GO:0042493,biological_process,response to drug;GO:0007568,biological_process,aging" "K04379,ko05166,HTLV-I infection;K04379,ko04662,B cell receptor signaling pathway;K04379,ko01522,Endocrine resistance;K04379,ko05161,Hepatitis B;K04379,ko05231,Choline metabolism in cancer;K04379,ko05168,Herpes simplex infection;K04379,ko05031,Amphetamine addiction;K04379,ko04024,cAMP signaling pathway;K04379,ko04668,TNF signaling pathway;K04379,ko04917,Prolactin signaling pathway;K04379,ko05200,Pathways in cancer;K04379,ko04725,Cholinergic synapse;K04379,ko05133,Pertussis;K04379,ko04380,Osteoclast differentiation;K04379,ko04915,Estrogen signaling pathway;K04379,ko05323,Rheumatoid arthritis;K04379,ko04620,Toll-like receptor signaling pathway;K04379,ko04921,Oxytocin signaling pathway;K04379,ko04660,T cell receptor signaling pathway;K04379,ko05142,Chagas disease (American trypanosomiasis);K04379,ko05132,Salmonella infection;K04379,ko04728,Dopaminergic synapse;K04379,ko05210,Colorectal cancer;K04379,ko05140,Leishmaniasis;K04379,ko04713,Circadian entrainment;K04379,ko04210,Apoptosis;K04379,ko04010,MAPK signaling pathway" CEP128 1.629145821 1.564293039 0.775703157 2.432463463 1.999717526 4.722925624 -1.164986159 4.345720074 7.786429314 0.028427702 0.742896758 "G9BAV9,Lens epithelium-derived protein" - - - "ENOG410XT5I,-;ENOG410IGDD,-" - - CKB 3.691032337 4.833480524 7.337536191 3.325987553 3.179949779 2.538792102 0.978813381 3.529189407 6.451186098 0.040461525 0.742896758 "H2Q8Y8,Creatine kinase, brain" "XP_009426805.1,-" "PF02807,ATP:guanido phosphotransferase, N-terminal domain;PF00217,ATP:guanido phosphotransferase, C-terminal catalytic domain" "IPR036802,ATP:guanido phosphotransferase, N-terminal domain superfamily;IPR022415,ATP:guanido phosphotransferase active site;IPR022413,ATP:guanido phosphotransferase, N-terminal;IPR000749,ATP:guanido phosphotransferase;IPR022414,ATP:guanido phosphotransferase, catalytic domain;IPR014746,Glutamine synthetase/guanido kinase, catalytic domain" "KOG3581,Creatine kinases;COG3869,Arginine kinase" "GO:0043209,cellular_component,myelin sheath;GO:0016301,molecular_function,kinase activity;GO:0031625,molecular_function,ubiquitin protein ligase binding;GO:0003824,molecular_function,catalytic activity;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding;GO:0004111,molecular_function,creatine kinase activity;GO:0005739,cellular_component,mitochondrion;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0016310,biological_process,phosphorylation;GO:0016772,molecular_function,transferase activity, transferring phosphorus-containing groups;GO:0005615,cellular_component,extracellular space" "K00933,ko00330,Arginine and proline metabolism" ZBTB42 1.303225077 1.22203979 1.362587544 0.903178755 0.9554387 0.708016398 0.724788756 2.107404997 7.94384623 0.026546764 0.742896758 "H2REQ1,Zinc finger and BTB domain containing 42" "XP_009426864.1,-" "PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger;PF00651,BTB/POZ domain" "IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily" "KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger" "GO:0005737,cellular_component,cytoplasm;GO:0003676,molecular_function,nucleic acid binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0005886,cellular_component,plasma membrane;GO:0007517,biological_process,muscle organ development;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" - PLD4 0.315832919 0.405238223 0.415700132 0.204362438 0.290028772 0.214293182 0.809324111 1.138963643 6.576128831 0.038154294 0.742896758 "F5H2B5,Phospholipase D4" "NP_001295103.1,phospholipase D4 isoform 1" "PF13918,PLD-like domain" "IPR001736,Phospholipase D/Transphosphatidylase;IPR032803,PLD-like domain" "KOG3603,Predicted phospholipase D;ENOG410XQZ4,-" "GO:0045335,cellular_component,phagocytic vesicle;GO:0006909,biological_process,phagocytosis;GO:0003824,molecular_function,catalytic activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0032588,cellular_component,trans-Golgi network membrane;GO:0016020,cellular_component,membrane;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0005634,cellular_component,nucleus;GO:0016021,cellular_component,integral component of membrane" - MKRN3 0.533611106 0.597614257 0.343867618 0.970052591 0.631140259 0.984630904 -0.739505111 1.954706504 6.499663387 0.039159102 0.742896758 "G3RZ99,Makorin ring finger protein 3" - "PF15815,3 ubiquitin-protein ligase makorin-1, C-terminal;PF00097,Zinc finger, C3HC4 type (RING finger)" - - - - ARHGAP11A 21.06013804 18.43891065 7.342624822 32.08381228 24.64380067 63.81976732 -1.340853095 7.462537543 7.368296535 0.031617808 0.742896758 "H2Q931,Rho GTPase activating protein 11A" "XP_510272.3,rho GTPase-activating protein 11A isoform X1" "PF00620,RhoGAP domain" "IPR008936,Rho GTPase activation protein;IPR000198,Rho GTPase-activating protein domain" "ENOG410YVI5,-;KOG2710,Rho GTPase-activating protein" "GO:0007165,biological_process,signal transduction" - CASC5 1.708131772 1.499171432 0.713779853 2.490271793 1.8839024 5.113947808 -1.242089568 4.500896727 7.094660605 0.033964229 0.742896758 "G1QS69,Kinetochore scaffold 1" - - "IPR037388,Kinetochore scaffold 1" "ENOG410XZXJ,-;ENOG410IF9C,-" "GO:0008608,biological_process,attachment of spindle microtubules to kinetochore;GO:0000777,cellular_component,condensed chromosome kinetochore;GO:0010923,biological_process,negative regulation of phosphatase activity;GO:0034501,biological_process,protein localization to kinetochore;GO:0001669,cellular_component,acrosomal vesicle;GO:0005829,cellular_component,cytosol;GO:0016604,cellular_component,nuclear body;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" - B2M 12.46392906 14.009447 13.24133377 9.586697268 10.31371653 7.119893869 0.67731205 6.097879731 7.37434712 0.030724232 0.742896758 "H2RCV0,Beta-2-microglobulin" - "PF07654,Immunoglobulin C1-set domain" - - - - C15orf48 1.977218248 2.080145647 1.648098753 1.021122057 1.378431406 0.790358776 0.944727212 1.10122576 10.76643255 0.013976687 0.742896758 "H0YKW5,Chromosome 15 open reading frame 48" - "PF06522,NADH-ubiquinone reductase complex 1 MLRQ subunit" "IPR010530,NADH-ubiquinone reductase complex 1 MLRQ subunit" "ENOG410J1F7,-;ENOG410YXE9,-" "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - CCDC33 1.886188053 1.796386569 1.185156021 1.078494248 1.277546575 0.75038698 0.736848102 3.233004284 8.384464689 0.023811299 0.742896758 "F7DNT2,Coiled-coil domain containing 33" "XP_014998184.1,coiled-coil domain-containing protein 33 isoform X4" - "IPR000008,C2 domain;IPR035892,C2 domain superfamily" "ENOG410IJ8S,-;ENOG410YHJ3,-" - - MPG 6.254237244 7.354349222 10.23319287 5.002509332 5.418387006 4.35236766 0.845055708 3.466912037 6.514316084 0.039755176 0.742896758 "Q1W6H1,DNA-3-methyladenine glycosylase" "NP_002425.2,DNA-3-methyladenine glycosylase isoform a" "PF02245,Methylpurine-DNA glycosylase (MPG)" "IPR011034,Formyl transferase-like, C-terminal domain superfamily;IPR003180,Methylpurine-DNA glycosylase;IPR036995,Methylpurine-DNA glycosylase superfamily" "COG2094,3-methyladenine DNA glycosylase;KOG4486,3-methyladenine DNA glycosylase" "GO:0003824,molecular_function,catalytic activity;GO:0003677,molecular_function,DNA binding;GO:0003905,molecular_function,alkylbase DNA N-glycosylase activity;GO:0006284,biological_process,base-excision repair" "K03652,ko03410,Base excision repair" RAB40C 3.272693298 3.845532414 3.57720732 2.45262179 2.827641753 1.848768876 0.70777031 3.655743856 7.880852552 0.026970799 0.742896758 "A0A0D9RJR9,RAB40C, member RAS oncogene family" "XP_007978449.1,-" "PF00071,Ras family;PF07525,SOCS box" "IPR036036,SOCS box-like domain superfamily;IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR001496,SOCS box domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" - "GO:0005525,molecular_function,GTP binding;GO:0003924,molecular_function,GTPase activity;GO:0016567,biological_process,protein ubiquitination;GO:0005622,cellular_component,intracellular;GO:0035556,biological_process,intracellular signal transduction" - SULT1A1 0.364225052 0.43312958 0.406462119 0.208005814 0.258945657 0.185694237 1.002933196 1.511147703 13.74808123 0.007941448 0.742896758 "H2R150,Sulfotransferase" "XP_016784285.1,-;XP_016784284.1,sulfotransferase 1A1-like isoform X2;XP_016784286.1,-" "PF00685,Sulfotransferase domain" "IPR000863,Sulfotransferase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "KOG1584,Sulfotransferase;ENOG4111H56,-" "GO:0008146,molecular_function,sulfotransferase activity;GO:0004062,molecular_function,aryl sulfotransferase activity;GO:0016740,molecular_function,transferase activity;GO:0047894,molecular_function,flavonol 3-sulfotransferase activity;GO:0006068,biological_process,ethanol catabolic process;GO:0050294,molecular_function,steroid sulfotransferase activity;GO:0050427,biological_process,3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0008210,biological_process,estrogen metabolic process;GO:0051923,biological_process,sulfation;GO:0009812,biological_process,flavonoid metabolic process;GO:0006805,biological_process,xenobiotic metabolic process" "K01014,ko05204,Chemical carcinogenesis" TMEM219 1.96139678 1.909006708 2.820511112 1.686493333 1.360698411 1.120049168 0.835589883 2.189837693 6.002071688 0.045997767 0.742896758 "A0A024R618,Testicular tissue protein Li 203" "NP_001077082.1,-;XP_005255180.1,-;NP_919256.1,insulin-like growth factor-binding protein 3 receptor precursor" "PF14940,Transmembrane 219" - "ENOG4110155,-;ENOG410IWEC,-" "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - ALDOA 69.48327301 88.75977705 131.2602481 56.85874204 53.98535126 43.0226971 1.077984466 8.883019607 7.836852656 0.02807209 0.742896758 "G3RDM7,Fructose-bisphosphate aldolase" - "PF00274,ructose-bisphosphate aldolase class-I" "IPR029768,Fructose-bisphosphate aldolase class-I active site;IPR000741,Fructose-bisphosphate aldolase, class-I;IPR013785,Aldolase-type TIM barrel" - "GO:0006941,biological_process,striated muscle contraction;GO:0004332,molecular_function,fructose-bisphosphate aldolase activity;GO:0070062,cellular_component,extracellular exosome;GO:0061827,cellular_component,sperm head;GO:0008092,molecular_function,cytoskeletal protein binding;GO:0070061,molecular_function,fructose binding;GO:0007339,biological_process,binding of sperm to zona pellucida;GO:0003824,molecular_function,catalytic activity;GO:0046716,biological_process,muscle cell cellular homeostasis;GO:0006754,biological_process,ATP biosynthetic process;GO:0030388,biological_process,fructose 1,6-bisphosphate metabolic process;GO:0006096,biological_process,glycolytic process;GO:0015629,cellular_component,actin cytoskeleton;GO:0045296,molecular_function,cadherin binding;GO:0005829,cellular_component,cytosol;GO:0008360,biological_process,regulation of cell shape;GO:0006000,biological_process,fructose metabolic process;GO:0016829,molecular_function,lyase activity" - TMEM265 6.076600097 6.792485645 8.269039901 3.845029117 4.866070666 2.528159222 1.058953176 2.472636966 9.620915332 0.018515231 0.742896758 "U3EVS8,Uncharacterized protein LOC100862671" - "PF04505,Interferon-induced transmembrane protein" "IPR007593,CD225/Dispanin family" - "GO:0009607,biological_process,response to biotic stimulus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - MMP2 0.421175271 0.41657336 0.479393144 0.230242358 0.190526503 0.248077381 1.093429134 0.783745322 11.78615048 0.011394283 0.742896758 "A0A024R6R4,Matrix metallopeptidase 2" "NP_004521.1,72 kDa type IV collagenase isoform 1 preproprotein" "PF00413,Matrixin;PF01471,Putative peptidoglycan binding domain;PF00040,ibronectin type II domain;PF00045,Hemopexin" "IPR001818,Peptidase M10, metallopeptidase;IPR018486,Hemopexin, conserved site;IPR036375,Hemopexin-like domain superfamily;IPR036365,PGBD-like superfamily;IPR021190,Peptidase M10A;IPR000562,Fibronectin type II domain;IPR002477,Peptidoglycan binding-like;IPR036366,PGBD superfamily;IPR024079,Metallopeptidase, catalytic domain superfamily;IPR013806,Kringle-like fold;IPR006026,Peptidase, metallopeptidase;IPR018487,Hemopexin-like repeats;IPR000585,Hemopexin-like domain;IPR036943,Fibronectin type II domain superfamily;IPR033739,Peptidase M10A, catalytic domain;IPR021158,Peptidase M10A, cysteine switch, zinc binding site;IPR028708,72kDa type IV collagenase" "KOG1565,Gelatinase A and related matrix metalloproteases;ENOG410XQ5D,-" "GO:0060325,biological_process,face morphogenesis;GO:0001666,biological_process,response to hypoxia;GO:0060346,biological_process,bone trabecula formation;GO:0048705,biological_process,skeletal system morphogenesis;GO:0005615,cellular_component,extracellular space;GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0031012,cellular_component,extracellular matrix;GO:0005739,cellular_component,mitochondrion;GO:0001955,biological_process,blood vessel maturation;GO:0008233,molecular_function,peptidase activity;GO:0030017,cellular_component,sarcomere;GO:0008270,molecular_function,zinc ion binding;GO:0008237,molecular_function,metallopeptidase activity;GO:0045089,biological_process,positive regulation of innate immune response;GO:0046872,molecular_function,metal ion binding;GO:0071230,biological_process,cellular response to amino acid stimulus;GO:0007566,biological_process,embryo implantation;GO:0001957,biological_process,intramembranous ossification;GO:0004222,molecular_function,metalloendopeptidase activity;GO:0005886,cellular_component,plasma membrane;GO:0030574,biological_process,collagen catabolic process" "K01398,ko01522,Endocrine resistance;K01398,ko04670,Leukocyte transendothelial migration;K01398,ko05219,Bladder cancer;K01398,ko04915,Estrogen signaling pathway;K01398,ko05200,Pathways in cancer;K01398,ko05205,Proteoglycans in cancer;K01398,ko04912,GnRH signaling pathway;K01398,ko04933,AGE-RAGE signaling pathway in diabetic complications" CES1 25.25208492 27.15530832 24.17250905 19.83447167 20.12179525 10.71773027 0.715605709 5.971790843 6.038883754 0.045022592 0.742896758 "K7AH75,Carboxylic ester hydrolase" - "PF07859,alpha/beta hydrolase fold;PF00135,Carboxylesterase family" "IPR019819,Carboxylesterase type B, conserved site;IPR019826,Carboxylesterase type B, active site;IPR029058,Alpha/Beta hydrolase fold;IPR002018,Carboxylesterase, type B" "COG2272,Carboxylesterase type B;KOG1516,Carboxylesterase and related proteins" "GO:0016787,molecular_function,hydrolase activity" - MT2A 70.32094037 82.12091544 175.6605404 37.48216579 41.83326775 45.44677818 1.583348932 6.706798045 10.29279212 0.016036323 0.742896758 "H3BSP9,Metallothionein" - "PF00131,Metallothionein" "IPR000006,Metallothionein, vertebrate;IPR017854,Metallothionein domain superfamily;IPR018064,Metallothionein, vertebrate, metal binding site;IPR023587,Metallothionein domain superfamily, vertebrate;IPR003019,Metallothionein" "ENOG410JFS1,-;ENOG41113QR,-" "GO:0046872,molecular_function,metal ion binding" - MT1X 3.054662421 4.545964802 2.83434775 0.708032672 0.754990859 0.562404083 2.459497356 1.924745853 80.60014447 5.08E-05 0.41796269 "L5LWA8,Uncharacterized protein" - - - - - - CDH16 0.606598583 0.7869089 0.330157825 0.367890921 0.342767045 0.161165353 1.061338788 0.692384764 6.584043139 0.038993796 0.742896758 "B2R7S8,cDNA, FLJ93586, highly similar to Homo sapiens cadherin 16, KSP-cadherin" - "PF00028,Cadherin domain" "IPR020894,Cadherin conserved site;IPR002126,Cadherin;IPR015919,Cadherin-like;IPR030721,Cadherin-16" "ENOG410XQHI,-;KOG3594,FOG: Cadherin repeats" "GO:0007155,biological_process,cell adhesion;GO:0007156,biological_process,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0005509,molecular_function,calcium ion binding;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0016339,biological_process,calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016021,cellular_component,integral component of membrane" - TRADD 4.010483129 4.812065115 4.107235469 3.108838322 2.629511341 2.048173016 0.846468878 3.170705945 11.82493666 0.011308827 0.742896758 "K7CAG9,TNFRSF1A-associated via death domain" "XP_511022.4,-;XP_016785506.1,-;XP_009429270.2,-" "PF09034,TRADD, N-terminal domain;PF00531,eath domain" "IPR035712,TRADD;IPR009095,TRADD, N-terminal;IPR036729,TRADD, N-terminal domain superfamily;IPR011029,Death-like domain superfamily;IPR000488,Death domain" "ENOG4111IRA,-;ENOG410IF81,-" "GO:0070513,molecular_function,death domain binding;GO:0007165,biological_process,signal transduction;GO:0005737,cellular_component,cytoplasm;GO:0042802,molecular_function,identical protein binding;GO:0004871,molecular_function,signal transducer activity;GO:0051798,biological_process,positive regulation of hair follicle development;GO:0060090,molecular_function,molecular adaptor activity;GO:0005886,cellular_component,plasma membrane;GO:0019900,molecular_function,kinase binding;GO:0043235,cellular_component,receptor complex;GO:0043123,biological_process,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0097191,biological_process,extrinsic apoptotic signaling pathway" "K03171,ko04622,RIG-I-like receptor signaling pathway;K03171,ko04064,NF-kappa B signaling pathway;K03171,ko05152,Tuberculosis;K03171,ko05203,Viral carcinogenesis;K03171,ko04210,Apoptosis;K03171,ko04920,Adipocytokine signaling pathway;K03171,ko04071,Sphingolipid signaling pathway;K03171,ko05160,Hepatitis C;K03171,ko04668,TNF signaling pathway;K03171,ko05169,Epstein-Barr virus infection" TPPP3 7.837962941 6.253305012 9.268261736 3.641948371 4.166598975 3.298069912 1.214635499 3.95804349 16.63366292 0.005223086 0.742896758 "A0A024R702,Brain specific protein, isoform CRA_a" "NP_057224.2,tubulin polymerization-promoting protein family member 3;NP_057048.2,-" "PF05517,p25-alpha" "IPR011992,EF-hand domain pair;IPR008907,P25-alpha;IPR030795,Tubulin polymerisation-promoting protein family member 3" "KOG4070,Putative signal transduction protein p25;ENOG4111H9J,-" "GO:0046785,biological_process,microtubule polymerization;GO:0001578,biological_process,microtubule bundle formation;GO:0015631,molecular_function,tubulin binding" - ADAT1 2.627943851 2.611068075 1.241025975 3.378013914 3.441062717 3.95049947 -0.677845273 3.6677248 6.15776446 0.04331766 0.742896758 "B2RBG6,cDNA, FLJ95496, highly similar to Homo sapiens adenosine deaminase, tRNA-specific 1" - "PF02137,Adenosine-deaminase (editase) domain" "IPR002466,Adenosine deaminase/editase" "ENOG410XT0Z,-;KOG2777,tRNA-specific adenosine deaminase 1" "GO:0003723,molecular_function,RNA binding;GO:0004000,molecular_function,adenosine deaminase activity;GO:0006396,biological_process,RNA processing" - RNASEK 10.79143358 12.44383873 14.66462523 9.690147707 9.249502258 6.929174681 0.692396025 4.280711051 5.78924188 0.048686907 0.742896758 "K7D5Z9,Ribonuclease, RNase K" "XP_003315387.1,-" - "IPR026770,Ribonuclease kappa" "ENOG411200W,-;ENOG410ITXX,-" "GO:0004521,molecular_function,endoribonuclease activity;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" "K19770,ko04212,Longevity regulating pathway - worm" CTD-2545G14.7 26.20235985 28.92356995 46.72806423 20.64504398 23.30583004 16.87993 0.911736389 4.44880589 6.017378694 0.045793127 0.742896758 "G3Q6Y0,CTD nuclear envelope phosphatase 1b" - "PF03031,NLI interacting factor-like phosphatase" "IPR004274,FCP1 homology domain;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR011948,Dullard phosphatase domain, eukaryotic" "KOG1605,TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation);COG5190,TFIIF-interacting CTD phosphatases, including NLI-interacting factor" "GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - KCTD11 5.55347772 6.813991499 6.351913409 3.677453916 3.746496007 3.018183103 0.963114884 3.92072104 16.26471396 0.005256692 0.742896758 "G3RRD5,Uncharacterized protein" "XP_004058519.1,-;XP_004058524.1,-" "PF02214,BTB/POZ domain" "IPR003131,Potassium channel tetramerisation-type BTB domain;IPR011333,SKP1/BTB/POZ domain superfamily" - "GO:0051260,biological_process,protein homooligomerization" - TMEM256-PLSCR3 2.357588731 2.970816746 3.655389743 2.185200147 1.994010698 1.734075296 0.74901154 3.046085589 5.816545795 0.048577034 0.742896758 "B2RBF8,Phospholipid scramblase" - "PF03803,Scramblase" "IPR005552,Scramblase" "ENOG410XSYS,-;KOG0621,Phospholipid scramblase" - - TMEM256 7.759476486 9.624029582 11.84653126 7.18691075 4.995222554 5.705649806 0.849561075 2.523346218 6.645009837 0.03834376 0.742896758 "G3QD08,Uncharacterized protein" "XP_004058527.1,-" "PF04241,Protein of unknown function (DUF423)" "IPR006696,Protein of unknown function DUF423" - "GO:0005743,cellular_component,mitochondrial inner membrane;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - SAT2 14.52102607 16.00939848 19.86598102 10.64219094 10.50479621 6.303520371 1.024817317 4.453214434 9.948208243 0.017249341 0.742896758 "K7DQ87,Spermidine/spermine N1-acetyltransferase family member 2" "XP_511959.2,diamine acetyltransferase 2 isoform X1" "PF00583,Acetyltransferase (GNAT) family" "IPR032959,Diamine acetyltransferase 2;IPR016181,Acyl-CoA N-acyltransferase;IPR000182,GNAT domain" "COG0454,Histone acetyltransferase HPA2 and related acetyltransferases;KOG3216,Diamine acetyltransferase" "GO:0032918,biological_process,spermidine acetylation;GO:0004145,molecular_function,diamine N-acetyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0032919,biological_process,spermine acetylation;GO:0008080,molecular_function,N-acetyltransferase activity;GO:0032920,biological_process,putrescine acetylation;GO:0046204,biological_process,nor-spermidine metabolic process;GO:0042802,molecular_function,identical protein binding" - LRRC75A 4.852111254 5.011485873 6.200121602 3.64007905 3.985003171 3.219951904 0.704937395 4.083954547 6.70544731 0.037114234 0.742896758 "G3S2A0,Leucine rich repeat containing 75A" "XP_004042236.2,leucine-rich repeat-containing protein 75A isoform X1" - "IPR032675,Leucine-rich repeat domain superfamily" - - - MAPK7 2.376678856 2.737656802 2.782919605 1.93278203 1.786903208 1.940865287 0.60032412 3.580920543 6.022148014 0.044746123 0.742896758 "A0A024QZ20,Mitogen-activated protein kinase" "NP_620602.2,-;NP_002740.2,mitogen-activated protein kinase 7 isoform 1;NP_620603.2,-" "PF00069,Protein kinase domain" "IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR003527,Mitogen-activated protein (MAP) kinase, conserved site;IPR008271,Serine/threonine-protein kinase, active site;IPR000719,Protein kinase domain" "ENOG410XNY0,-;KOG0660,Mitogen-activated protein kinase" "GO:0004672,molecular_function,protein kinase activity;GO:0018105,biological_process,peptidyl-serine phosphorylation;GO:0016301,molecular_function,kinase activity;GO:0051534,-,-;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0005737,cellular_component,cytoplasm;GO:0000165,biological_process,MAPK cascade;GO:0070377,biological_process,negative regulation of ERK5 cascade;GO:0004707,molecular_function,MAP kinase activity;GO:0016740,molecular_function,transferase activity;GO:0016310,biological_process,phosphorylation;GO:0045765,biological_process,regulation of angiogenesis;GO:0043407,biological_process,negative regulation of MAP kinase activity;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0005524,molecular_function,ATP binding;GO:0005829,cellular_component,cytosol;GO:0006468,biological_process,protein phosphorylation;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" "K04464,ko04011,MAPK signaling pathway - yeast;K04464,ko05206,MicroRNAs in cancer;K04464,ko04010,MAPK signaling pathway;K04464,ko04912,GnRH signaling pathway;K04464,ko04139,Regulation of mitophagy - yeast;K04464,ko04722,Neurotrophin signaling pathway;K04464,ko04540,Gap junction;K04464,ko04921,Oxytocin signaling pathway" ATAD5 1.521102409 1.465175027 0.602353392 2.978347836 1.892012427 4.830359133 -1.403132466 3.949647072 9.683528019 0.018263866 0.742896758 "K7C8V0,ATPase family, AAA domain containing 5" - "PF00004,ATPase family associated with various cellular activities (AAA)" "IPR003959,ATPase, AAA-type, core;IPR003593,AAA+ ATPase domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "ENOG410YF58,-;KOG1968,Replication factor C, subunit RFC1 (large subunit)" "GO:0005524,molecular_function,ATP binding" - RARA 3.118516909 4.12159222 4.045756795 2.533402347 2.967881401 2.078936889 0.704626684 3.921550741 6.737589586 0.036755374 0.742896758 "A8MUP8,Retinoic acid receptor alpha" "XP_005257609.1,retinoic acid receptor alpha isoform X4" "PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor" "IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003078,Retinoic acid receptor;IPR013088,Zinc finger, NHR/GATA-type" - "GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0003708,molecular_function,retinoic acid receptor activity;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0015629,cellular_component,actin cytoskeleton;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0048384,biological_process,retinoic acid receptor signaling pathway;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway" - BRCA1 3.189520954 3.001897728 2.139790155 5.427071455 4.216898713 11.24734242 -1.26360771 5.431420298 9.02464342 0.021152623 0.742896758 "G8I0D8,Breast cancer type 1 susceptibility protein" - "PF12820,Serine-rich domain associated with BRCT;PF00533,BRCA1 C Terminus (BRCT) domain;PF00097,Zinc finger, C3HC4 type (RING finger)" "IPR017907,Zinc finger, RING-type, conserved site;IPR036420,BRCT domain superfamily;IPR025994,BRCA1, serine-rich domain;IPR001841,Zinc finger, RING-type;IPR031099,BRCA1-associated;IPR013083,Zinc finger, RING/FYVE/PHD-type;IPR011364,Breast cancer type 1 susceptibility protein (BRCA1);IPR018957,Zinc finger, C3HC4 RING-type;IPR001357,BRCT domain" "ENOG4112BIH,-;ENOG410ITQ4,-" "GO:0085020,biological_process,protein K6-linked ubiquitination;GO:0003677,molecular_function,DNA binding;GO:0005694,cellular_component,chromosome;GO:0006974,biological_process,cellular response to DNA damage stimulus;GO:0031436,cellular_component,BRCA1-BARD1 complex;GO:0046872,molecular_function,metal ion binding;GO:0007049,biological_process,cell cycle;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0051865,biological_process,protein autoubiquitination;GO:0006281,biological_process,DNA repair;GO:0006310,biological_process,DNA recombination;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding" - ARL4D 6.531237511 6.62889156 4.615020207 4.635405324 4.717357552 2.783586213 0.646849583 3.011454083 6.298583344 0.041284629 0.742896758 "G1R162,ADP ribosylation factor like GTPase 4D" - "PF00025,ADP-ribosylation factor family" - - - - ITGB3 0.255014666 0.254622118 0.089699832 0.088429271 0.090744551 0.087678557 1.209317519 -0.557124557 7.674287779 0.028424894 0.742896758 "L7UUZ7,Integrin beta" - "PF00362,Integrin beta chain VWA domain;PF17205,Integrin plexin domain;PF07965,Integrin beta tail domain;PF08725,Integrin beta cytoplasmic domain;PF07974,-like domain" "IPR027068,Integrin beta-3 subunit;IPR015812,Integrin beta subunit;IPR036465,von Willebrand factor A-like domain superfamily;IPR014836,Integrin beta subunit, cytoplasmic domain;IPR002369,Integrin beta subunit, VWA domain;IPR016201,PSI domain;IPR032695,Integrin domain superfamily;IPR013111,EGF-like domain, extracellular;IPR012896,Integrin beta subunit, tail;IPR033760,Integrin beta N-terminal;IPR036349,Integrin beta tail domain superfamily" "ENOG410XP60,-;KOG1226,Integrin beta subunit (N-terminal portion of extracellular region)" "GO:0008305,cellular_component,integrin complex;GO:0030334,biological_process,regulation of cell migration;GO:0007155,biological_process,cell adhesion;GO:0004872,-,-;GO:0007044,biological_process,cell-substrate junction assembly;GO:0007160,biological_process,cell-matrix adhesion;GO:0070527,biological_process,platelet aggregation;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0016020,cellular_component,membrane;GO:0060055,biological_process,angiogenesis involved in wound healing;GO:0016021,cellular_component,integral component of membrane" - PRR11 5.366938864 6.290225967 3.272433463 8.256129512 6.533836408 10.5368717 -0.702199449 4.757927871 5.829003315 0.048209236 0.742896758 "D2SNZ4,Proline rich 11, isoform CRA_a" "NP_060774.2,proline-rich protein 11" - - "ENOG4112CB1,-;ENOG410IJIM,-" - - CTD-2510F5.6 5.07123981 5.984911869 3.449618824 7.35153647 7.823278782 9.520619012 -0.69505796 1.864905523 7.201238815 0.0321627 0.742896758 "A0A1D5QS43,Proline rich 11" - - "IPR019354,Smg8/Smg9;IPR028802,Protein SMG8" - "GO:0000184,biological_process,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" - BRIP1 0.771235069 0.888626698 0.280525253 1.432551974 0.926669328 2.387896422 -1.267846156 3.136686131 6.714961806 0.037615408 0.742896758 "A0A024QZ45,BRCA1 interacting protein C-terminal helicase 1, isoform CRA_a" "NP_114432.2,Fanconi anemia group J protein" "PF13307,Helicase C-terminal domain;PF06733,AD_2" "IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR013020,ATP-dependent helicase Rad3/Chl1-like;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR006554,Helicase-like, DEXD box c2 type;IPR014013,Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type;IPR010614,DEAD2;IPR006555,ATP-dependent helicase, C-terminal" "COG1199,Rad3-related DNA helicases;KOG1132,Helicase of the DEAD superfamily" "GO:0007283,biological_process,spermatogenesis;GO:0003676,molecular_function,nucleic acid binding;GO:0072520,biological_process,seminiferous tubule development;GO:0032508,biological_process,DNA duplex unwinding;GO:0005634,cellular_component,nucleus;GO:0016787,molecular_function,hydrolase activity;GO:0005737,cellular_component,cytoplasm;GO:0016818,molecular_function,hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0005524,molecular_function,ATP binding;GO:0008584,biological_process,male gonad development;GO:0007129,biological_process,synapsis;GO:0009636,biological_process,response to toxic substance;GO:1904385,biological_process,cellular response to angiotensin;GO:0003682,molecular_function,chromatin binding;GO:0051026,biological_process,chiasma assembly;GO:0004386,molecular_function,helicase activity;GO:0003677,molecular_function,DNA binding;GO:0008026,molecular_function,ATP-dependent helicase activity;GO:0010629,biological_process,negative regulation of gene expression;GO:0031965,cellular_component,nuclear membrane;GO:0071456,biological_process,cellular response to hypoxia;GO:0000166,molecular_function,nucleotide binding;GO:0007284,biological_process,spermatogonial cell division;GO:0007286,biological_process,spermatid development;GO:1990918,biological_process,double-strand break repair involved in meiotic recombination;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0010705,biological_process,meiotic DNA double-strand break processing involved in reciprocal meiotic recombination;GO:0071295,biological_process,cellular response to vitamin;GO:0004003,molecular_function,ATP-dependent DNA helicase activity;GO:0006139,biological_process,nucleobase-containing compound metabolic process" "K15362,ko03460,Fanconi anemia pathway" APOH 10.48047417 10.09650742 4.512500915 4.869319291 5.794522279 3.981219812 0.836959224 3.129946893 7.873352395 0.027656351 0.742896758 "G1QHF4,Apolipoprotein H" "XP_003268711.1,beta-2-glycoprotein 1" "PF00084,Sushi repeat (SCR repeat);PF09014,Beta-2-glycoprotein-1 fifth domain" "IPR000436,Sushi/SCR/CCP domain;IPR015104,Beta-2-glycoprotein-1 fifth domain;IPR035976,Sushi/SCR/CCP superfamily" "ENOG410XPJ1,-;KOG4297,C-type lectin" "GO:0001937,biological_process,negative regulation of endothelial cell proliferation;GO:0034364,cellular_component,high-density lipoprotein particle;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space;GO:0009986,cellular_component,cell surface;GO:0034392,biological_process,negative regulation of smooth muscle cell apoptotic process;GO:0031012,cellular_component,extracellular matrix;GO:0034361,cellular_component,very-low-density lipoprotein particle;GO:0008289,molecular_function,lipid binding;GO:0042802,molecular_function,identical protein binding;GO:0031639,biological_process,plasminogen activation;GO:0042627,cellular_component,chylomicron;GO:0051917,biological_process,regulation of fibrinolysis;GO:0007597,biological_process,blood coagulation, intrinsic pathway;GO:0051006,biological_process,positive regulation of lipoprotein lipase activity;GO:0051918,biological_process,negative regulation of fibrinolysis;GO:0030195,biological_process,negative regulation of blood coagulation;GO:0016525,biological_process,negative regulation of angiogenesis;GO:0010596,biological_process,negative regulation of endothelial cell migration;GO:0006641,biological_process,triglyceride metabolic process;GO:0033033,biological_process,negative regulation of myeloid cell apoptotic process;GO:0060230,molecular_function,lipoprotein lipase activator activity;GO:0005543,molecular_function,phospholipid binding" - GPRC5C 1.624343339 1.97095546 1.892541803 1.276960648 1.384015124 0.911588965 0.746150726 3.620182648 8.057442563 0.025875998 0.742896758 "A0A0C4DFY5,G-protein-coupled receptor family C group 5 member C" "NP_071319.2,G-protein coupled receptor family C group 5 member C isoform a" "PF00003,7 transmembrane sweet-taste receptor of 3 GCPR" "IPR017978,GPCR family 3, C-terminal" "ENOG410IEI6,-;ENOG4110E9P,-" "GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane;GO:0007186,biological_process,G-protein coupled receptor signaling pathway" - SMIM6 4.815065131 4.162895068 4.128319151 3.137529155 3.356856029 2.524992364 0.6509495 2.030096303 7.638529069 0.028686939 0.742896758 "G1QKF4,Small integral membrane protein 6" - - - - - - METRNL 1.902405201 2.38240691 2.241996244 1.63900589 1.149644893 0.578208677 1.089720161 2.152977286 7.494115864 0.030610411 0.742896758 "H9F471,Meteorin-like protein" - - - "ENOG410IGT2,-;ENOG4111N7F,-" - - C18orf54 0.843358363 0.764610407 0.373855347 1.134030272 1.00072844 2.063610218 -1.04136139 2.633126257 6.921846895 0.035565268 0.742896758 "H2QEK1,Uncharacterized protein" "XP_016788685.1,-;XP_009432222.1,lung adenoma susceptibility protein 2 isoform X1;XP_009432224.1,-" "PF15792,Lung adenoma susceptibility protein 2" "IPR031587,Lung adenoma susceptibility protein 2" "ENOG410IGEU,-;ENOG4111V88,-" "GO:0008285,biological_process,negative regulation of cell proliferation" - RAB27B 5.895797309 5.447072222 3.317875442 8.735079541 8.645417389 7.083502195 -0.662524089 5.573722053 8.420787331 0.023602545 0.742896758 "G3RHZ4,RAB27B, member RAS oncogene family" "XP_004059498.1,-;XP_018869284.1,-" "PF00071,Ras family" "IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" - "GO:0019904,molecular_function,protein domain specific binding;GO:0005794,cellular_component,Golgi apparatus;GO:0019003,molecular_function,GDP binding;GO:0005525,molecular_function,GTP binding;GO:0005795,cellular_component,Golgi stack;GO:0031489,molecular_function,myosin V binding;GO:0042470,cellular_component,melanosome;GO:0071985,biological_process,multivesicular body sorting pathway;GO:0030140,cellular_component,trans-Golgi network transport vesicle;GO:0003924,molecular_function,GTPase activity;GO:0032585,cellular_component,multivesicular body membrane;GO:0045921,biological_process,positive regulation of exocytosis" "K07886,ko04972,Pancreatic secretion" RTTN 0.8752239 0.881294426 0.724684271 1.351983992 1.133941289 1.651678197 -0.647133238 3.316265836 6.910751366 0.034780966 0.742896758 "K7C2J4,Rotatin" - "PF14726,Rotatin, an armadillo repeat protein, centriole functioning" "IPR011989,Armadillo-like helical;IPR030791,Rotatin;IPR016024,Armadillo-type fold;IPR029249,Rotatin, N-terminal" "ENOG410XRDG,-;ENOG410IEI0,-" "GO:0044782,biological_process,cilium organization;GO:0036064,cellular_component,ciliary basal body;GO:0005813,cellular_component,centrosome" - HCN2 6.027914157 7.657848026 6.404214024 5.349867093 4.763518328 2.759643834 0.762800577 4.242209175 6.662407664 0.03803773 0.742896758 "H0WXB3,Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2" - "PF00027,Cyclic nucleotide-binding domain;PF00520,Ion transport protein;PF08412,Ion transport protein N-terminal" "IPR014710,RmlC-like jelly roll fold;IPR018488,Cyclic nucleotide-binding, conserved site;IPR000595,Cyclic nucleotide-binding domain;IPR018490,Cyclic nucleotide-binding-like;IPR005821,Ion transport domain;IPR013621,Ion transport N-terminal;IPR003938,Potassium channel, voltage-dependent, EAG/ELK/ERG" "ENOG410XPSE,-;KOG0498,K+-channel ERG and related proteins, contain PAS/PAC sensor domain" "GO:0005267,molecular_function,potassium channel activity;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0005886,cellular_component,plasma membrane;GO:0098855,cellular_component,HCN channel complex;GO:0005222,molecular_function,intracellular cAMP activated cation channel activity;GO:0005248,molecular_function,voltage-gated sodium channel activity;GO:0042391,biological_process,regulation of membrane potential;GO:1990573,biological_process,potassium ion import across plasma membrane;GO:0035725,biological_process,sodium ion transmembrane transport;GO:0042802,molecular_function,identical protein binding;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0071321,biological_process,cellular response to cGMP;GO:0006811,biological_process,ion transport;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0016020,cellular_component,membrane;GO:0005216,molecular_function,ion channel activity;GO:0055085,biological_process,transmembrane transport;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0098719,biological_process,sodium ion import across plasma membrane;GO:0006813,biological_process,potassium ion transport;GO:0071320,biological_process,cellular response to cAMP" - BTBD2 3.11050106 3.234397478 4.363965132 2.393541137 2.683254073 1.952071335 0.755957822 4.173626438 6.164919814 0.043880976 0.742896758 "H9FBH5,BTB/POZ domain-containing protein 2" - "PF08005,PHR domain;PF00651,BTB/POZ domain;PF07707,BTB And C-terminal Kelch" "IPR011705,BTB/Kelch-associated;IPR000210,BTB/POZ domain;IPR038648,PHR domain superfamily;IPR011333,SKP1/BTB/POZ domain superfamily;IPR012983,PHR" "KOG2075,Topoisomerase TOP1-interacting protein BTBD1;ENOG410XQ3X,-" - - ANGPTL4 14.59734635 24.18515683 2.282746893 4.636301776 4.83095386 1.269163422 1.960902471 4.371605881 5.866522951 0.04786379 0.742896758 "K7AXV2,Angiopoietin-like 4" "XP_016790418.1,angiopoietin-related protein 4 isoform X1" "PF00147,ibrinogen beta and gamma chains, C-terminal globular domain" "IPR020837,Fibrinogen, conserved site;IPR028793,Angiopoietin-related protein 4;IPR002181,Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;IPR036056,Fibrinogen-like, C-terminal" "ENOG410ZYS4,-;KOG2579,Ficolin and related extracellular proteins" "GO:0070328,biological_process,triglyceride homeostasis;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0001525,biological_process,angiogenesis;GO:0004857,molecular_function,enzyme inhibitor activity;GO:2000352,biological_process,negative regulation of endothelial cell apoptotic process;GO:0051005,biological_process,negative regulation of lipoprotein lipase activity;GO:0042802,molecular_function,identical protein binding;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space" "K08767,ko03320,PPAR signaling pathway" MIR1199 2.380064662 2.774084422 2.448731119 2.133121373 1.693846878 1.578853789 0.605023914 2.377928009 6.231743989 0.042088429 0.742896758 "A0A044PY82,Uncharacterized protein MISP3" - "PF15304,A-kinase anchor protein 2 C-terminus" "IPR029304,A-kinase anchor protein 2, C-terminal domain" "ENOG410IHG4,-;ENOG4111C5I,-" - - KLF2 0.925449655 1.210661453 1.171876304 2.977060357 3.923523019 1.336381096 -1.175421412 1.946148923 7.818266856 0.028202483 0.742896758 "K7CWI5,Kruppel-like factor 2" "XP_003316222.2,Krueppel-like factor 2" "PF00096,Zinc finger, C2H2 type" "IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily" "KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger" "GO:0034101,biological_process,erythrocyte homeostasis;GO:0003676,molecular_function,nucleic acid binding;GO:0035264,biological_process,multicellular organism growth;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0071499,biological_process,cellular response to laminar fluid shear stress;GO:0005634,cellular_component,nucleus;GO:0000902,biological_process,cell morphogenesis;GO:0060509,biological_process,Type I pneumocyte differentiation;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0000790,cellular_component,nuclear chromatin;GO:0036003,biological_process,positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:1903671,biological_process,negative regulation of sprouting angiogenesis;GO:0003677,molecular_function,DNA binding;GO:0040029,biological_process,regulation of gene expression, epigenetic;GO:0043249,biological_process,erythrocyte maturation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0051247,biological_process,positive regulation of protein metabolic process;GO:0045429,biological_process,positive regulation of nitric oxide biosynthetic process;GO:0071498,biological_process,cellular response to fluid shear stress;GO:0000981,molecular_function,RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0097533,biological_process,cellular stress response to acid chemical;GO:0001701,biological_process,in utero embryonic development" "K17845,ko04068,FoxO signaling pathway" RAB3A 0.719081509 0.577728845 0.514898254 0.295931619 0.28198837 0.261776068 1.20100866 -0.214463959 13.8319123 0.00782641 0.742896758 "G5B4D4,Ras-related protein Rab-3A" "XP_004873398.2,-" "PF00071,Ras family" "IPR037872,Rab3;IPR005225,Small GTP-binding protein domain;IPR001806,Small GTPase superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase" - "GO:0007409,biological_process,axonogenesis;GO:0016188,biological_process,synaptic vesicle maturation;GO:0005525,molecular_function,GTP binding;GO:0007005,biological_process,mitochondrion organization;GO:0050975,biological_process,sensory perception of touch;GO:0048172,biological_process,regulation of short-term neuronal synaptic plasticity;GO:0003016,biological_process,respiratory system process;GO:0007274,biological_process,neuromuscular synaptic transmission;GO:1903307,biological_process,positive regulation of regulated secretory pathway;GO:0003924,molecular_function,GTPase activity;GO:0008021,cellular_component,synaptic vesicle;GO:0031630,biological_process,regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0030742,molecular_function,GTP-dependent protein binding;GO:0005768,cellular_component,endosome;GO:0001669,cellular_component,acrosomal vesicle;GO:0016079,biological_process,synaptic vesicle exocytosis;GO:0048790,biological_process,maintenance of presynaptic active zone structure;GO:0009791,biological_process,post-embryonic development;GO:0031489,molecular_function,myosin V binding;GO:0030324,biological_process,lung development;GO:0061670,biological_process,evoked neurotransmitter secretion;GO:0017157,biological_process,regulation of exocytosis;GO:0051602,biological_process,response to electrical stimulus;GO:0043195,cellular_component,terminal bouton" "K07882,ko04911,Insulin secretion;K07882,ko04721,Synaptic vesicle cycle" ZNF708 0.172722072 0.290359926 0.170870403 0.393914065 0.368769068 0.440146952 -0.835826071 0.441583785 6.29262731 0.041355433 0.742896758 "G3QPG8,Zinc finger protein 708" - "PF00096,Zinc finger, C2H2 type;PF01352,KRAB box" "IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily" - "GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular" - GPI 36.77419746 48.05372472 49.05676401 28.42940887 26.352265 25.09469833 0.874290589 8.372278683 9.579529723 0.018031866 0.742896758 "A0A0A0MTS2,Glucose-6-phosphate isomerase" - "PF00342,Phosphoglucose isomerase" "IPR023096,Phosphoglucose isomerase, C-terminal;IPR001672,Phosphoglucose isomerase (PGI);IPR035482,Phosphoglucose isomerase, SIS domain 2;IPR018189,Phosphoglucose isomerase, conserved site;IPR035476,Phosphoglucose isomerase, SIS domain 1" "KOG2446,Glucose-6-phosphate isomerase;COG0166,Glucose-6-phosphate isomerase" "GO:0004347,molecular_function,glucose-6-phosphate isomerase activity;GO:0006096,biological_process,glycolytic process;GO:0006094,biological_process,gluconeogenesis;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0016853,molecular_function,isomerase activity;GO:0005654,cellular_component,nucleoplasm" - RP11-618P17.4 87.72151052 119.3684452 143.9080244 68.00229082 64.88598716 66.84688789 0.957253802 6.525571354 8.684802787 0.022878801 0.742896758 "K7ESF4,Uncharacterized protein" - "PF00342,Phosphoglucose isomerase" "IPR001672,Phosphoglucose isomerase (PGI);IPR035482,Phosphoglucose isomerase, SIS domain 2" "KOG2061,Uncharacterized MYND Zn-finger protein;KOG2446,Glucose-6-phosphate isomerase;COG0166,Glucose-6-phosphate isomerase" "GO:0006094,biological_process,gluconeogenesis;GO:0004347,molecular_function,glucose-6-phosphate isomerase activity;GO:0006096,biological_process,glycolytic process" - CNFN 5.14894558 5.376889745 3.676689025 3.568846989 2.928376738 3.420019673 0.600659306 1.307859375 5.888400258 0.046558132 0.742896758 "A0A0D9S168,Cornifelin" - "PF04749,PLAC8 family" "IPR006461,PLAC8 motif-containing protein" - "GO:0001533,cellular_component,cornified envelope" - ZNF428 22.93014534 20.55336298 33.92444054 14.80363867 17.58134145 16.15146516 0.828224681 5.289519127 5.899844604 0.047395923 0.742896758 "M0QXZ5,Zinc finger protein 428" - - "IPR013087,Zinc finger C2H2-type" - "GO:0003676,molecular_function,nucleic acid binding" - KCNN4 6.160838503 7.018549724 8.253714123 5.207190816 5.394817332 3.996397182 0.694342955 4.335267647 6.086612742 0.04446744 0.742896758 "K7BT53,Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4" "XP_016791575.1,intermediate conductance calcium-activated potassium channel protein 4 isoform X1" "PF07885,Ion channel;PF02888,Calmodulin binding domain;PF03530,Calcium-activated SK potassium channel" "IPR015449,Potassium channel, calcium-activated, SK;IPR004178,Calmodulin-binding domain;IPR013099,Potassium channel domain;IPR036122,SK, calmodulin-binding domain superfamily" "ENOG410XT9D,-;KOG3684,Ca2+-activated K+ channel proteins (intermediate/small conductance classes)" "GO:0046541,biological_process,saliva secretion;GO:0005267,molecular_function,potassium channel activity;GO:0030322,biological_process,stabilization of membrane potential;GO:0015269,molecular_function,calcium-activated potassium channel activity;GO:0045332,biological_process,phospholipid translocation;GO:0005516,molecular_function,calmodulin binding;GO:0006816,biological_process,calcium ion transport;GO:0019903,molecular_function,protein phosphatase binding;GO:0006884,biological_process,cell volume homeostasis;GO:0016286,molecular_function,small conductance calcium-activated potassium channel activity;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0005886,cellular_component,plasma membrane;GO:0050862,biological_process,positive regulation of T cell receptor signaling pathway;GO:0016020,cellular_component,membrane;GO:0006813,biological_process,potassium ion transport;GO:0031982,cellular_component,vesicle;GO:0050714,biological_process,positive regulation of protein secretion;GO:0016021,cellular_component,integral component of membrane" "K04945,ko04974,Protein digestion and absorption;K04945,ko04911,Insulin secretion;K04945,ko04970,Salivary secretion" ZNF180 2.157276742 2.114771477 1.102161138 2.980785619 2.751022647 3.563050549 -0.731816683 3.529749634 7.493354535 0.029926151 0.742896758 "H2QGJ8,Zinc finger protein 180" - "PF00096,Zinc finger, C2H2 type;PF01352,KRAB box" "IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily" "KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger" "GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular" - ZNF296 0.883448887 1.256854057 2.175233794 0.616976701 0.636899191 0.532772623 1.448071845 0.936915053 9.188971798 0.020379078 0.742896758 "G3QLI5,Zinc finger protein 296" "XP_004060995.1,zinc finger protein 296" "PF00096,Zinc finger, C2H2 type" "IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily" - "GO:0007283,biological_process,spermatogenesis;GO:0003676,molecular_function,nucleic acid binding;GO:0001076,molecular_function,transcription factor activity, RNA polymerase II transcription factor binding;GO:0005634,cellular_component,nucleus;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II" - FOSB 0.037835442 0.098683301 0.053233531 10.46360487 17.03823192 0.159162759 -7.04417904 4.60435679 19.38747822 0.003583493 0.742896758 "K7CED2,FBJ murine osteosarcoma viral oncogene homolog B" "XP_016791702.1,-" "PF00170,bZIP transcription factor" "IPR000837,AP-1 transcription factor;IPR004827,Basic-leucine zipper domain;IPR029813,Protein FosB" - "GO:0006366,biological_process,transcription by RNA polymerase II;GO:0071277,biological_process,cellular response to calcium ion;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0003677,molecular_function,DNA binding;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" "K09029,ko04380,Osteoclast differentiation;K09029,ko05034,Alcoholism;K09029,ko05030,Cocaine addiction;K09029,ko05031,Amphetamine addiction" QPCTL 1.617354597 2.001209611 1.840339377 1.284881734 1.212455838 0.974215276 0.773073931 1.872542459 9.008997923 0.02053121 0.742896758 "G3QIU7,Glutaminyl-peptide cyclotransferase like" - "PF04389,Peptidase family M28" "IPR007484,Peptidase M28" - "GO:0005794,cellular_component,Golgi apparatus;GO:0016603,molecular_function,glutaminyl-peptide cyclotransferase activity;GO:0017186,biological_process,peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane;GO:0008270,molecular_function,zinc ion binding" - BBC3 3.641149656 3.805474784 5.066199991 2.35917059 2.758520193 1.468062768 1.079248539 3.385509497 9.678035823 0.018285735 0.742896758 "H2QGP2,BCL2 binding component 3" - - "IPR031661,Bcl-2-binding component 3" "ENOG41119TR,-;ENOG410IW36,-" "GO:0090200,biological_process,positive regulation of release of cytochrome c from mitochondria;GO:0097193,biological_process,intrinsic apoptotic signaling pathway;GO:0005739,cellular_component,mitochondrion;GO:0043065,biological_process,positive regulation of apoptotic process" - NDUFA3 1.858125296 1.900431044 3.413898606 1.340480558 1.588021778 1.181188013 0.974698156 2.288329171 5.932041142 0.046949583 0.742896758 "K7BXN9,NADH dehydrogenase" "NP_001238904.1,-;XP_016792292.1,-" "PF14987,NADH dehydrogenase 1 alpha subcomplex subunit 3" "IPR026626,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3" "ENOG410J189,-;ENOG411212S,-" "GO:0005743,cellular_component,mitochondrial inner membrane;GO:0005747,cellular_component,mitochondrial respiratory chain complex I;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" "K03947,ko05010,Alzheimer's disease;K03947,ko05012,Parkinson's disease;K03947,ko00190,Oxidative phosphorylation;K03947,ko05016,Huntington's disease;K03947,ko04932,Non-alcoholic fatty liver disease (NAFLD)" ZNF581 8.054917088 10.48259241 7.634212708 5.888289163 7.497544467 4.334039717 0.670583116 3.676725132 6.541272479 0.038612763 0.742896758 "H2P088,Zinc finger protein 581" "XP_003779314.1,-" "PF00096,Zinc finger, C2H2 type;PF13894,C2H2-type zinc finger" "IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily" "KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger" "GO:0003676,molecular_function,nucleic acid binding" - ZSCAN5A 0.348468231 0.329470139 0.22675736 0.59116381 0.499539293 0.389028646 -0.619505064 1.674066395 6.050172917 0.044378238 0.742896758 "A0A024R4S6,Zinc finger and SCAN domain containing 5, isoform CRA_a" "NP_001308993.1,-;NP_077279.1,zinc finger and SCAN domain-containing protein 5A isoform b;NP_001308995.1,-;NP_001308996.1,-;NP_001308994.1,-;NP_001308997.1,-;NP_001308998.1,-;NP_001308999.1,-;NP_001309001.1,-" "PF00096,Zinc finger, C2H2 type;PF12874,Zinc-finger of C2H2 type;PF02023,SCAN domain" "IPR003309,SCAN domain;IPR013087,Zinc finger C2H2-type;IPR038269,SCAN domain superfamily;IPR036236,Zinc finger C2H2 superfamily" "KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger" "GO:0003676,molecular_function,nucleic acid binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus" - TAF1B 2.682545853 2.696793154 1.430507059 3.566980896 3.672232405 4.070743001 -0.668709152 3.598897606 7.348982844 0.030929664 0.742896758 "G3QJP7,TATA-box binding protein associated factor, RNA polymerase I subunit B" "XP_018877012.1,TATA box-binding protein-associated factor RNA polymerase I subunit B" "PF11781,Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7" "IPR033599,RNA polymerase I transcription initiation factor TAF1B/Rrn7;IPR021752,Transcription initiation factor Rrn7, Zinc-finger" - "GO:0006360,biological_process,transcription by RNA polymerase I;GO:0001188,biological_process,RNA polymerase I transcriptional preinitiation complex assembly;GO:0070860,cellular_component,RNA polymerase I core factor complex;GO:0001164,molecular_function,RNA polymerase I CORE element sequence-specific DNA binding" - GEN1 0.953359079 0.924742921 0.437397604 1.311612374 1.230548894 2.169083916 -0.980560457 3.773903464 7.651933914 0.029405654 0.742896758 "H2QHG9,Gen homolog 1, endonuclease" "XP_009440316.1,-;XP_009440318.1,-;XP_009440317.1,-;XP_003949810.1,flap endonuclease GEN homolog 1 isoform X1;XP_009440315.1,-" "PF00867,XPG I-region;PF00752,XPG N-terminal domain" "IPR006085,XPG N-terminal;IPR008918,Helix-hairpin-helix motif, class 2;IPR036279,5'-3' exonuclease, C-terminal domain superfamily;IPR006084,XPG/Rad2 endonuclease;IPR006086,XPG-I domain;IPR029060,PIN-like domain superfamily" "KOG2519,5'-3' exonuclease;COG0258,5'-3' exonuclease (including N-terminal domain of PolI)" "GO:0003677,molecular_function,DNA binding;GO:0003824,molecular_function,catalytic activity;GO:0004518,molecular_function,nuclease activity;GO:0006281,biological_process,DNA repair;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis;GO:0004519,molecular_function,endonuclease activity" - WDR54 4.709705517 6.50656353 8.337599421 3.824967913 3.903665575 3.193328059 0.994228491 3.91088324 8.558868434 0.023565311 0.742896758 "K7A5B2,WD repeat domain 54" - - - - - - WBP1 5.122760518 5.525586848 6.335276016 4.413483868 4.275628419 3.086092268 0.66488019 3.576510213 5.831771747 0.047701731 0.742896758 "A8MX15,HCG2039828, isoform CRA_g" - "PF11669,WW domain-binding protein 1" "IPR021684,WW domain-binding protein 1-like" - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - ARID5A 0.484569593 0.659686793 0.801549147 0.276673236 0.399450566 0.387770552 1.006375506 0.919938643 7.007510827 0.034614422 0.742896758 "K7BCT7,AT rich interactive domain 5A" "XP_016804468.1,AT-rich interactive domain-containing protein 5A isoform X3" "PF01388,ARID/BRIGHT DNA binding domain" "IPR001606,ARID DNA-binding domain;IPR036431,ARID DNA-binding domain superfamily" "ENOG410Y2AP,-;KOG2744,DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain" "GO:0071391,biological_process,cellular response to estrogen stimulus;GO:0030331,molecular_function,estrogen receptor binding;GO:0050681,molecular_function,androgen receptor binding;GO:0003677,molecular_function,DNA binding;GO:0005730,cellular_component,nucleolus;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0003714,molecular_function,transcription corepressor activity;GO:0008134,molecular_function,transcription factor binding;GO:0046966,molecular_function,thyroid hormone receptor binding;GO:0005634,cellular_component,nucleus;GO:0046965,molecular_function,retinoid X receptor binding;GO:0005654,cellular_component,nucleoplasm" - NT5DC4 0.375721608 0.389104167 0.297354944 0.63669075 0.444907568 1.142503171 -0.99279556 1.234933659 5.7745393 0.04918744 0.742896758 "H2QIK3,Uncharacterized protein" - "PF05761,5' nucleotidase family" "IPR008380,HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase;IPR023214,HAD superfamily;IPR036412,HAD-like superfamily;IPR016695,Purine 5'-nucleotidase" "ENOG410XQAV,-;KOG2469,IMP-GMP specific 5'-nucleotidase" "GO:0016311,biological_process,dephosphorylation;GO:0046872,molecular_function,metal ion binding;GO:0008253,molecular_function,5'-nucleotidase activity" - CKAP2L 3.972003677 3.622456166 2.303372761 5.721250131 4.529428062 9.661559716 -0.950051202 4.683864343 7.192758655 0.033097476 0.742896758 "H2QIK4,Uncharacterized protein" "XP_515696.4,cytoskeleton-associated protein 2-like" "PF15297,Cytoskeleton-associated protein 2 C-terminus" "IPR029197,Cytoskeleton-associated protein 2, C-terminal;IPR026165,Cytoskeleton-associated protein 2 family" "ENOG4111T8P,-;ENOG410IGXX,-" "GO:0005829,cellular_component,cytosol;GO:0072686,cellular_component,mitotic spindle;GO:0005813,cellular_component,centrosome" - EPC2 2.735091684 3.035108158 1.059139368 4.262221148 4.316513483 4.149211641 -0.853540759 4.153127073 6.78499974 0.036904326 0.742896758 "G7N818,Enhancer of polycomb homolog" "XP_014965554.1,-" "PF06752,nhancer of Polycomb C-terminus;PF10513,nhancer of polycomb-like" "IPR019542,Enhancer of polycomb-like, N-terminal;IPR009607,Enhancer of polycomb, C-terminal;IPR024943,Enhancer of polycomb protein" "ENOG410XSSX,-;KOG2261,Polycomb enhancer protein, EPC" "GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0035267,cellular_component,NuA4 histone acetyltransferase complex;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0032777,cellular_component,Piccolo NuA4 histone acetyltransferase complex;GO:0005634,cellular_component,nucleus" - ITGB6 0.113839625 0.16522118 0.108501944 0.197473954 0.232971987 0.338669368 -0.905747505 0.340521086 5.982301397 0.045276122 0.742896758 "G3R1W1,Integrin beta" "XP_004032744.2,integrin beta-6 isoform X1" "PF00362,Integrin beta chain VWA domain;PF17205,Integrin plexin domain;PF07965,Integrin beta tail domain;PF08725,Integrin beta cytoplasmic domain;PF07974,-like domain" "IPR015812,Integrin beta subunit;IPR036465,von Willebrand factor A-like domain superfamily;IPR014836,Integrin beta subunit, cytoplasmic domain;IPR002369,Integrin beta subunit, VWA domain;IPR016201,PSI domain;IPR032695,Integrin domain superfamily;IPR013111,EGF-like domain, extracellular;IPR012896,Integrin beta subunit, tail;IPR015436,Integrin beta-6 subunit;IPR033760,Integrin beta N-terminal;IPR036349,Integrin beta tail domain superfamily" - "GO:0008305,cellular_component,integrin complex;GO:0030054,cellular_component,cell junction;GO:0016021,cellular_component,integral component of membrane;GO:0007155,biological_process,cell adhesion;GO:0009897,cellular_component,external side of plasma membrane;GO:0005925,cellular_component,focal adhesion;GO:0016020,cellular_component,membrane;GO:0004872,-,-;GO:0007160,biological_process,cell-matrix adhesion;GO:0034685,cellular_component,integrin alphav-beta6 complex;GO:0005178,molecular_function,integrin binding;GO:0006954,biological_process,inflammatory response;GO:0005813,cellular_component,centrosome;GO:0038044,biological_process,transforming growth factor-beta secretion;GO:0007229,biological_process,integrin-mediated signaling pathway;GO:0043235,cellular_component,receptor complex;GO:0033627,biological_process,cell adhesion mediated by integrin;GO:0005654,cellular_component,nucleoplasm" "K06589,ko04510,Focal adhesion;K06589,ko05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);K06589,ko05410,Hypertrophic cardiomyopathy (HCM);K06589,ko04151,PI3K-Akt signaling pathway;K06589,ko05414,Dilated cardiomyopathy;K06589,ko04810,Regulation of actin cytoskeleton;K06589,ko04512,ECM-receptor interaction" OSBPL6 0.174788805 0.256437183 0.117957505 0.309664124 0.344666091 0.319632349 -0.755131196 1.542296518 7.025213414 0.033717121 0.742896758 "G3QYZ4,Oxysterol-binding protein" - "PF15409,Pleckstrin homology domain;PF01237,Oxysterol-binding protein" "IPR000648,Oxysterol-binding protein;IPR037239,Oxysterol-binding protein superfamily;IPR001849,Pleckstrin homology domain;IPR018494,Oxysterol-binding protein, conserved site;IPR011993,PH-like domain superfamily" - "GO:0006869,biological_process,lipid transport" - SLC39A10 7.121125711 6.572242558 2.029966082 13.05838379 12.42253146 9.773272358 -1.127094331 5.833190841 7.97955877 0.027096832 0.742896758 "H2QJ63,Solute carrier family 39" - "PF02535,ZIP Zinc transporter" "IPR003689,Zinc/iron permease" "KOG2693,Putative zinc transporter;COG0428,Predicted divalent heavy-metal cations transporter" "GO:0030001,biological_process,metal ion transport;GO:0055085,biological_process,transmembrane transport;GO:0071578,biological_process,zinc ion import across plasma membrane;GO:0006882,biological_process,cellular zinc ion homeostasis;GO:0016020,cellular_component,membrane;GO:0050861,biological_process,positive regulation of B cell receptor signaling pathway;GO:0005887,cellular_component,integral component of plasma membrane;GO:0005385,molecular_function,zinc ion transmembrane transporter activity;GO:0046873,molecular_function,metal ion transmembrane transporter activity" - CCDC150 0.6991527 0.756929096 0.424852561 1.172968661 0.791215741 1.855956442 -0.966249724 3.193689056 6.597881643 0.038844981 0.742896758 "H2R6B2,Uncharacterized protein" - - - "ENOG410Y643,-;ENOG410IHQS,-" - - SGO2 4.37272657 3.962193108 3.272509661 6.606174608 5.079443116 10.87957335 -0.880925805 5.093788521 6.634990014 0.038449606 0.742896758 "K7C9V9,Shugoshin-like 2" "XP_009442228.2,shugoshin-like 2;XP_016804972.1,-;XP_016804973.1,-" - "IPR026706,Shugoshin 2" "ENOG410Z3EE,-;ENOG410IVI8,-" "GO:0051754,biological_process,meiotic sister chromatid cohesion, centromeric;GO:0030892,cellular_component,mitotic cohesin complex;GO:0000775,cellular_component,chromosome, centromeric region;GO:0016604,cellular_component,nuclear body;GO:0005654,cellular_component,nucleoplasm" - OBSL1 3.66768765 4.029186495 2.634852079 2.671390213 2.595900845 1.799121464 0.639438097 4.799073212 7.728811807 0.028031321 0.742896758 "H2RCR6,Obscurin like 1" "XP_003309516.1,obscurin-like protein 1 isoform X7" "PF13927,Immunoglobulin domain;PF07679,Immunoglobulin I-set domain" "IPR003961,Fibronectin type III;IPR007110,Immunoglobulin-like domain;IPR036116,Fibronectin type III superfamily;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR003599,Immunoglobulin subtype;IPR003598,Immunoglobulin subtype 2;IPR013098,Immunoglobulin I-set" "KOG0613,Projectin/twitchin and related proteins;ENOG410XQFD,-" "GO:0006941,biological_process,striated muscle contraction;GO:1990393,cellular_component,3M complex;GO:0008307,molecular_function,structural constituent of muscle;GO:0045214,biological_process,sarcomere organization;GO:0005737,cellular_component,cytoplasm;GO:0048471,cellular_component,perinuclear region of cytoplasm;GO:0031430,cellular_component,M band;GO:0000226,biological_process,microtubule cytoskeleton organization;GO:0005794,cellular_component,Golgi apparatus;GO:0097493,molecular_function,structural molecule activity conferring elasticity;GO:0005859,cellular_component,muscle myosin complex;GO:0050775,biological_process,positive regulation of dendrite morphogenesis;GO:0007015,biological_process,actin filament organization;GO:0007030,biological_process,Golgi organization;GO:0007088,biological_process,regulation of mitotic nuclear division;GO:0005813,cellular_component,centrosome;GO:0051015,molecular_function,actin filament binding;GO:0034067,biological_process,protein localization to Golgi apparatus;GO:0030018,cellular_component,Z disc;GO:0071688,biological_process,striated muscle myosin thick filament assembly;GO:0051371,molecular_function,muscle alpha-actinin binding" - FERMT1 3.201751008 2.726819028 2.155861154 3.904154781 4.267606414 4.757439668 -0.593002394 4.219412834 7.35056002 0.030916838 0.742896758 "Q54A15,DTGCU2" "NP_060141.3,fermitin family homolog 1" "PF00373,RM central domain;PF00169,PH domain" "IPR019748,FERM central domain;IPR037837,Kindlin/fermitin, PH domain;IPR001849,Pleckstrin homology domain;IPR011993,PH-like domain superfamily;IPR035963,FERM superfamily, second domain;IPR019749,Band 4.1 domain;IPR037843,Kindlin/fermitin" "KOG3727,Mitogen inducible gene product (contains ERM and PH domains);ENOG410XS1B,-" "GO:0007229,biological_process,integrin-mediated signaling pathway" - ESF1 44.73630396 41.7821252 22.57333866 63.90466639 58.00665615 69.69229649 -0.752159188 7.30737045 7.79449961 0.027566567 0.742896758 "G1RWU3,ESF1 nucleolar pre-rRNA processing protein homolog" - "PF08159,NUC153 domain" "IPR012580,NUC153" "COG5638,Uncharacterized conserved protein;KOG2318,Uncharacterized conserved protein" "GO:0005634,cellular_component,nucleus" - EIF2S2 116.8190204 110.5966109 63.15197905 145.630557 149.3742084 175.8890183 -0.632587596 8.374805036 5.713004049 0.049083482 0.742896758 "H2P1P6,Eukaryotic translation initiation factor 2 subunit 2" - "PF01873,omain found in IF2B/IF5" "IPR016190,Translation initiation factor IF2/IF5, zinc-binding;IPR016189,Translation initiation factor IF2/IF5, N-terminal;IPR002735,Translation initiation factor IF2/IF5" "COG1601,Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain;KOG2768,Translation initiation factor 2, beta subunit (eIF-2beta)" "GO:0003743,molecular_function,translation initiation factor activity;GO:0005737,cellular_component,cytoplasm;GO:0006413,biological_process,translational initiation;GO:0005850,cellular_component,eukaryotic translation initiation factor 2 complex" - SOGA1 2.671157677 2.614125724 1.315714153 3.459532177 3.272056749 4.240947318 -0.67778491 5.446649529 6.021868085 0.045087033 0.742896758 "G3REI8,Suppressor of glucose, autophagy associated 1" - "PF14818,omain of unknown function (DUF4482);PF11365,Protein SOGA" "IPR027881,Protein SOGA;IPR027882,Domain of unknown function DUF4482" - "GO:0010506,biological_process,regulation of autophagy;GO:0005615,cellular_component,extracellular space" - RBL1 2.854345378 2.649898968 0.794372315 4.24190192 3.573257734 7.63911532 -1.279843083 4.405325471 6.705992384 0.037707774 0.742896758 "H2QKB0,Retinoblastoma-like 1" "XP_001139919.1,retinoblastoma-like protein 1 isoform X1" "PF01857,Retinoblastoma-associated protein B domain;PF11934,omain of unknown function (DUF3452);PF01858,Retinoblastoma-associated protein A domain;PF08934,Rb C-terminal domain" "IPR013763,Cyclin-like;IPR036915,Cyclin-like superfamily;IPR002720,Retinoblastoma-associated protein, A-box;IPR015030,Retinoblastoma-associated protein, C-terminal;IPR002719,Retinoblastoma-associated protein, B-box;IPR028310,Retinoblastoma-like protein 1;IPR028309,Retinoblastoma protein family;IPR024599,Retinoblastoma-associated protein, N-terminal" "ENOG410XQF7,-;KOG1010,Rb (Retinoblastoma tumor suppressor)-related protein" "GO:2000773,biological_process,negative regulation of cellular senescence;GO:0005667,cellular_component,transcription factor complex;GO:0043550,biological_process,regulation of lipid kinase activity;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:1990841,molecular_function,promoter-specific chromatin binding;GO:0007049,biological_process,cell cycle;GO:0010629,biological_process,negative regulation of gene expression;GO:0008134,molecular_function,transcription factor binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0051726,biological_process,regulation of cell cycle;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" "K04681,ko04110,Cell cycle;K04681,ko04350,TGF-beta signaling pathway;K04681,ko05203,Viral carcinogenesis" SNX21 1.710932447 1.639742209 2.380986196 1.102647326 1.057699122 1.276358374 0.877525663 2.689058779 7.387583286 0.031460583 0.742896758 "H2QKH1,Sorting nexin family member 21" "XP_003953806.1,sorting nexin-21 isoform X4" "PF00787,PX domain" - "ENOG41114JN,-;ENOG410IMHU,-" - - PLTP 0.762530817 0.73683337 0.804646504 0.329356403 0.269004254 0.338909276 1.407445455 0.542865249 19.48152169 0.003308399 0.742896758 "B3KUE5,Phospholipid transfer protein, isoform CRA_c" - "PF01273,LBP / BPI / CETP family, N-terminal domain;PF02886,LBP / BPI / CETP family, C-terminal domain" "IPR017942,Lipid-binding serum glycoprotein, N-terminal;IPR030675,Lipid binding protein BPI/LBP;IPR017943,Bactericidal permeability-increasing protein, alpha/beta domain superfamily;IPR017954,Lipid-binding serum glycoprotein, conserved site;IPR030179,Phospholipid transfer protein;IPR001124,Lipid-binding serum glycoprotein, C-terminal;IPR032942,BPI/LBP/Plunc family" "KOG4160,BPI/LBP/CETP family protein;ENOG410Z88E,-" "GO:0006629,biological_process,lipid metabolic process;GO:0008289,molecular_function,lipid binding;GO:0005615,cellular_component,extracellular space" - EYA2 1.354985679 1.609280381 1.756640312 1.065697365 0.842301911 0.98341225 0.833464756 2.244215035 8.619568893 0.022633455 0.742896758 "A8KAG7,Eyes absent homolog" - "PF00702,haloacid dehalogenase-like hydrolase" "IPR028473,Eyes absent homologue 2;IPR028472,Eyes absent family;IPR036412,HAD-like superfamily;IPR006545,EYA domain;IPR038102,EYA domain superfamily" "KOG3107,Predicted haloacid dehalogenase-like hydrolase (eyes absent);ENOG410XT12,-" "GO:0016787,molecular_function,hydrolase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0014706,biological_process,striated muscle tissue development;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006470,biological_process,protein dephosphorylation;GO:0007275,biological_process,multicellular organism development" - KCNB1 0.053974126 0.038627726 0.022226418 0.064049261 0.075486313 0.097126089 -0.985058222 0.099584983 6.451105106 0.039524417 0.742896758 "H2P291,Potassium voltage-gated channel subfamily B member 1" "XP_002830449.1,potassium voltage-gated channel subfamily B member 1" "PF02214,BTB/POZ domain;PF00520,Ion transport protein;PF03521,Kv2 voltage-gated K+ channel" "IPR004350,Potassium channel, voltage dependent, Kv2.1;IPR003131,Potassium channel tetramerisation-type BTB domain;IPR000210,BTB/POZ domain;IPR011333,SKP1/BTB/POZ domain superfamily;IPR003968,Potassium channel, voltage dependent, Kv;IPR027359,Voltage-dependent channel domain superfamily;IPR005821,Ion transport domain;IPR003973,Potassium channel, voltage dependent, Kv2;IPR028325,Voltage-gated potassium channel" "KOG3713,Voltage-gated K+ channel KCNB/KCNC;COG1226,Kef-type K+ transport systems, predicted NAD-binding component" "GO:0005267,molecular_function,potassium channel activity;GO:0090314,biological_process,positive regulation of protein targeting to membrane;GO:0051260,biological_process,protein homooligomerization;GO:0005244,molecular_function,voltage-gated ion channel activity;GO:0005886,cellular_component,plasma membrane;GO:0098900,biological_process,regulation of action potential;GO:0042593,biological_process,glucose homeostasis;GO:0046676,biological_process,negative regulation of insulin secretion;GO:0032809,cellular_component,neuronal cell body membrane;GO:0001508,biological_process,action potential;GO:0016021,cellular_component,integral component of membrane;GO:0071333,biological_process,cellular response to glucose stimulus;GO:0030425,cellular_component,dendrite;GO:1900454,biological_process,positive regulation of long term synaptic depression;GO:0006811,biological_process,ion transport;GO:0071805,biological_process,potassium ion transmembrane transport;GO:0016020,cellular_component,membrane;GO:0008076,cellular_component,voltage-gated potassium channel complex;GO:0005216,molecular_function,ion channel activity;GO:0005251,molecular_function,delayed rectifier potassium channel activity;GO:0055085,biological_process,transmembrane transport;GO:0044325,molecular_function,ion channel binding;GO:0005249,molecular_function,voltage-gated potassium channel activity;GO:0034765,biological_process,regulation of ion transmembrane transport;GO:0006813,biological_process,potassium ion transport" - EEF1A2 66.40255826 74.30350765 110.839894 50.25718468 55.22951679 30.88674237 1.05022211 7.067638234 7.234428743 0.032738109 0.742896758 "A0A291PNG1,Translation elongation factor 1 alpha 2" - - "IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR000795,Transcription factor, GTP-binding domain;IPR004161,Translation elongation factor EFTu-like, domain 2;IPR004160,Translation elongation factor EFTu/EF1A, C-terminal;IPR004539,Translation elongation factor EF1A, eukaryotic/archaeal;IPR009000,Translation protein, beta-barrel domain superfamily;IPR031157,Tr-type G domain, conserved site;IPR009001,Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal" - "GO:0003746,molecular_function,translation elongation factor activity;GO:0005525,molecular_function,GTP binding;GO:0005737,cellular_component,cytoplasm;GO:0006414,biological_process,translational elongation;GO:0003924,molecular_function,GTPase activity;GO:0000166,molecular_function,nucleotide binding" - PPDPF 22.85367893 23.35462313 58.49968482 16.55648142 17.13014908 17.91856843 1.218652227 4.921204037 5.721761312 0.04996884 0.742896758 "X6R7I6,Pancreatic progenitor cell differentiation and proliferation factor" - "PF15060,ifferentiation and proliferation regulator" "IPR026754,Pancreatic progenitor cell differentiation and proliferation factor" - "GO:0030154,biological_process,cell differentiation;GO:0007275,biological_process,multicellular organism development" - IFNGR2 7.500198866 8.554604465 6.932422 6.139381374 6.071419192 4.164968419 0.599189353 4.28910921 6.650116329 0.037372708 0.742896758 "E7EUY1,Interferon gamma receptor 2" "NP_001316057.1,interferon gamma receptor 2 isoform 1 precursor" "PF01108,Tissue factor;PF09294,Interferon-alpha/beta receptor, fibronectin type III" "IPR003961,Fibronectin type III;IPR015373,Interferon/interleukin receptor domain;IPR013783,Immunoglobulin-like fold;IPR036116,Fibronectin type III superfamily" "ENOG410IVC9,-;ENOG410YR1U,-" "GO:0051607,biological_process,defense response to virus;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - CSTB 11.64410791 14.49748346 18.69795708 9.470881444 9.848189013 9.046728591 0.808647141 4.967245461 6.62295682 0.038577231 0.742896758 "H2P3B6,Cystatin B" "XP_002830797.1,-" "PF00031,Cystatin domain" "IPR001713,Proteinase inhibitor I25A, stefin;IPR000010,Cystatin domain;IPR018073,Proteinase inhibitor I25, cystatin, conserved site" "ENOG41121QW,-;ENOG410IZK7,-" "GO:0004866,molecular_function,endopeptidase inhibitor activity;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0010466,biological_process,negative regulation of peptidase activity;GO:0005730,cellular_component,nucleolus;GO:0005737,cellular_component,cytoplasm;GO:0002020,molecular_function,protease binding;GO:0005622,cellular_component,intracellular;GO:0005829,cellular_component,cytosol;GO:0045861,biological_process,negative regulation of proteolysis;GO:0004869,molecular_function,cysteine-type endopeptidase inhibitor activity;GO:0005615,cellular_component,extracellular space" - PFKL 8.243531451 9.001657472 10.01249005 6.586583797 6.218813427 5.664312584 0.691542069 6.11437003 7.107808119 0.03297579 0.742896758 "K7DD35,ATP-dependent 6-phosphofructokinase" "XP_001150758.1,-" "PF00365,Phosphofructokinase" "IPR022953,ATP-dependent 6-phosphofructokinase;IPR035966,Phosphofructokinase superfamily;IPR009161,ATP-dependent 6-phosphofructokinase, eukaryotic-type;IPR015912,Phosphofructokinase, conserved site;IPR000023,Phosphofructokinase domain" "COG0205,6-phosphofructokinase;KOG2440,Pyrophosphate-dependent phosphofructo-1-kinase" "GO:0006096,biological_process,glycolytic process;GO:0009749,biological_process,response to glucose;GO:0005524,molecular_function,ATP binding;GO:0016301,molecular_function,kinase activity;GO:0005737,cellular_component,cytoplasm;GO:0046676,biological_process,negative regulation of insulin secretion;GO:0070061,molecular_function,fructose binding;GO:0003824,molecular_function,catalytic activity;GO:0016310,biological_process,phosphorylation;GO:0019900,molecular_function,kinase binding;GO:0005829,cellular_component,cytosol;GO:0042802,molecular_function,identical protein binding;GO:0070095,molecular_function,fructose-6-phosphate binding;GO:0005945,cellular_component,6-phosphofructokinase complex;GO:0006002,biological_process,fructose 6-phosphate metabolic process;GO:0016740,molecular_function,transferase activity;GO:0051259,biological_process,protein complex oligomerization;GO:0008152,biological_process,metabolic process;GO:0061615,biological_process,glycolytic process through fructose-6-phosphate;GO:0000166,molecular_function,nucleotide binding;GO:0046872,molecular_function,metal ion binding;GO:0003872,molecular_function,6-phosphofructokinase activity;GO:0030388,biological_process,fructose 1,6-bisphosphate metabolic process" "K00850,ko04152,AMPK signaling pathway;K00850,ko01230,Biosynthesis of amino acids;K00850,ko00010,Glycolysis / Gluconeogenesis;K00850,ko03018,RNA degradation;K00850,ko00052,Galactose metabolism;K00850,ko00680,Methane metabolism;K00850,ko01200,Carbon metabolism;K00850,ko00051,Fructose and mannose metabolism;K00850,ko00030,Pentose phosphate pathway;K00850,ko05230,Central carbon metabolism in cancer" LRRC3 0.28638638 0.315123657 0.277020257 0.147688484 0.16014095 0.139008999 1.081054767 0.44834581 14.00684872 0.007593232 0.742896758 "G3QZD3,Leucine rich repeat containing 3" "XP_004062945.1,leucine-rich repeat-containing protein 3" "PF13855,Leucine rich repeat;PF00560,Leucine Rich Repeat;PF01462,Leucine rich repeat N-terminal domain" "IPR001611,Leucine-rich repeat;IPR000372,Leucine-rich repeat N-terminal domain;IPR003591,Leucine-rich repeat, typical subtype;IPR032675,Leucine-rich repeat domain superfamily" - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - CABP7 0.32233846 0.32228016 0.687842068 0.183424937 0.139826083 0.229474326 1.427039736 0.174992809 7.130236195 0.033646482 0.742896758 "Q5NCJ7,Calcium binding protein 7" "NP_620398.1,calcium-binding protein 7" "PF13499,-hand domain pair" "IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR001751,S100/Calbindin-D9k, conserved site;IPR011992,EF-hand domain pair" "KOG0027,Calmodulin and related proteins (EF-Hand superfamily);COG5126,Ca2+-binding protein (EF-Hand superfamily)" "GO:0046872,molecular_function,metal ion binding;GO:0016020,cellular_component,membrane;GO:0032588,cellular_component,trans-Golgi network membrane;GO:0016021,cellular_component,integral component of membrane;GO:0005509,molecular_function,calcium ion binding" - PIK3IP1 0.361977289 0.40805091 0.252488526 0.219946023 0.247008472 0.113162742 0.915642646 0.089684172 5.791689487 0.047928847 0.742896758 "A0A024R1M3,HGFL gene, isoform CRA_a" "NP_443112.2,phosphoinositide-3-kinase-interacting protein 1 isoform 1 precursor" "PF00051,Kringle domain" "IPR038178,Kringle superfamily;IPR018056,Kringle, conserved site;IPR000001,Kringle;IPR013806,Kringle-like fold" "ENOG4112B5B,-;ENOG410IIHU,-" "GO:0014067,biological_process,negative regulation of phosphatidylinositol 3-kinase signaling;GO:0043553,biological_process,negative regulation of phosphatidylinositol 3-kinase activity;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - PMM1 5.815445873 5.944088713 5.215660473 4.52276917 4.617906357 3.02788682 0.592954143 4.63531016 6.367526384 0.040476503 0.742896758 "H2QLS6,Phosphomannomutase" "XP_515159.2,-" "PF03332,ukaryotic phosphomannomutase" "IPR023214,HAD superfamily;IPR006379,HAD-superfamily hydrolase, subfamily IIB;IPR036412,HAD-like superfamily;IPR005002,Phosphomannomutase" "KOG3189,Phosphomannomutase;COG0561,Predicted hydrolases of the HAD superfamily" "GO:0006487,biological_process,protein N-linked glycosylation;GO:0006013,biological_process,mannose metabolic process;GO:0005737,cellular_component,cytoplasm;GO:0009298,biological_process,GDP-mannose biosynthetic process;GO:0043025,cellular_component,neuronal cell body;GO:1990830,biological_process,cellular response to leukemia inhibitory factor;GO:0005829,cellular_component,cytosol;GO:0016853,molecular_function,isomerase activity;GO:0004615,molecular_function,phosphomannomutase activity;GO:0045047,biological_process,protein targeting to ER" - A4GALT 6.512337024 7.160964783 7.081280576 4.661601743 4.896805177 2.826053155 0.873116414 4.046657831 9.746540093 0.017681759 0.742896758 "A0A0S2Z5J1,Alpha 14-galactosyltransferase isoform 1" "NP_059132.1,lactosylceramide 4-alpha-galactosyltransferase;NP_001304967.1,-;XP_006724328.1,-;XP_005261705.1,-;XP_005261704.1,-;XP_005261701.1,-;XP_011528535.1,-;XP_005261703.1,-;XP_016884320.1,-;XP_006724329.1,-" "PF04572,Alpha 1,4-glycosyltransferase conserved region;PF04488,lycosyltransferase sugar-binding region containing DXD motif" "IPR007577,Glycosyltransferase, DXD sugar-binding motif;IPR029044,Nucleotide-diphospho-sugar transferases;IPR007652,Alpha 1,4-glycosyltransferase domain" - "GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0008378,molecular_function,galactosyltransferase activity;GO:0015643,molecular_function,toxic substance binding;GO:0050512,molecular_function,lactosylceramide 4-alpha-galactosyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0001576,biological_process,globoside biosynthetic process;GO:0016020,cellular_component,membrane;GO:0016021,cellular_component,integral component of membrane" "K01988,ko00603,Glycosphingolipid biosynthesis - globo series" XYLB 1.336965576 1.333305034 0.940538754 2.069804343 1.64712241 2.205579383 -0.632746895 3.078867994 7.394591242 0.030561549 0.742896758 "K7CXC6,Xylulokinase homolog" "XP_009443462.1,xylulose kinase isoform X4" "PF02782,Y family of carbohydrate kinases, C-terminal domain;PF00370,Y family of carbohydrate kinases, N-terminal domain" "IPR018484,Carbohydrate kinase, FGGY, N-terminal;IPR000577,Carbohydrate kinase, FGGY;IPR018485,Carbohydrate kinase, FGGY, C-terminal" "KOG2531,Sugar (pentulose and hexulose) kinases;COG1070,Sugar (pentulose and hexulose) kinases" "GO:0005975,biological_process,carbohydrate metabolic process;GO:0016301,molecular_function,kinase activity;GO:0004856,molecular_function,xylulokinase activity;GO:0016773,molecular_function,phosphotransferase activity, alcohol group as acceptor;GO:0046835,biological_process,carbohydrate phosphorylation;GO:0005997,biological_process,xylulose metabolic process;GO:0016310,biological_process,phosphorylation" "K00854,ko00040,Pentose and glucuronate interconversions" KLHDC8B 2.271704442 2.518173305 4.531800342 1.662044126 2.006063696 1.596234421 0.99792943 2.46329904 5.85617727 0.048010294 0.742896758 "A0A1D5QNB8,Kelch domain containing 8B" "NP_001244521.1,kelch domain-containing protein 8B" - "IPR015915,Kelch-type beta propeller;IPR006652,Kelch repeat type 1" "ENOG4110X8D,-;KOG1072,FOG: Kelch repeat" - - ABHD14A-ACY1 1.78479021 1.644962635 2.369730717 1.525530294 1.154547216 1.018638569 0.796343232 2.958688364 6.069071465 0.045110875 0.742896758 "A0A1B0GW23,ABHD14A-ACY1 readthrough" - "PF12697,Alpha/beta hydrolase family;PF01546,Peptidase family M20/M25/M40;PF07687,Peptidase dimerisation domain" "IPR011650,Peptidase M20, dimerisation domain;IPR002933,Peptidase M20;IPR000073,Alpha/beta hydrolase fold-1;IPR036264,Bacterial exopeptidase dimerisation domain;IPR010159,N-acyl-L-amino-acid amidohydrolase;IPR001261,ArgE/DapE/ACY1/CPG2/YscS, conserved site;IPR029058,Alpha/Beta hydrolase fold" - "GO:0006508,biological_process,proteolysis;GO:0016787,molecular_function,hydrolase activity;GO:0006520,biological_process,cellular amino acid metabolic process;GO:0005737,cellular_component,cytoplasm;GO:0008237,molecular_function,metallopeptidase activity;GO:0004046,molecular_function,aminoacylase activity;GO:0008152,biological_process,metabolic process" - PDE12 0.597505652 0.653314996 0.357929601 0.978820208 0.884952437 0.977719757 -0.750515057 2.716999164 10.0507238 0.016259074 0.742896758 "G3QLA4,Phosphodiesterase 12" "XP_004034400.1,2',5'-phosphodiesterase 12 isoform X1" "PF03372,ndonuclease/Exonuclease/phosphatase family" "IPR036691,Endonuclease/exonuclease/phosphatase superfamily;IPR005135,Endonuclease/exonuclease/phosphatase" - "GO:0035457,biological_process,cellular response to interferon-alpha;GO:0090503,biological_process,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0071346,biological_process,cellular response to interferon-gamma;GO:0090324,biological_process,negative regulation of oxidative phosphorylation;GO:0045070,biological_process,positive regulation of viral genome replication;GO:0060548,biological_process,negative regulation of cell death;GO:0000288,biological_process,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0071359,biological_process,cellular response to dsRNA;GO:0000175,molecular_function,3'-5'-exoribonuclease activity;GO:0005759,cellular_component,mitochondrial matrix;GO:0005739,cellular_component,mitochondrion;GO:0044528,biological_process,regulation of mitochondrial mRNA stability;GO:0004527,molecular_function,exonuclease activity;GO:0000958,biological_process,mitochondrial mRNA catabolic process;GO:0090305,biological_process,nucleic acid phosphodiester bond hydrolysis" - ARL6 0.336846274 0.21964262 0.226195954 0.4835577 0.529267634 0.376549397 -0.723636843 0.749536604 5.659306954 0.049892514 0.742896758 "G1QNA6,ADP ribosylation factor like GTPase 6" - "PF00025,ADP-ribosylation factor family" - - - - POLQ 1.142388838 1.112494118 0.568674274 1.898275408 1.321025517 4.636133729 -1.440493507 4.053926801 7.512130725 0.030469644 0.742896758 "A0A087WXL3,DNA polymerase theta" - "PF00271,Helicase conserved C-terminal domain;PF00476,NA polymerase family A;PF00270,AD/DEAH box helicase" "IPR014001,Helicase superfamily 1/2, ATP-binding domain;IPR011545,DEAD/DEAH box helicase domain;IPR002298,DNA polymerase A;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR019760,DNA-directed DNA polymerase, family A, conserved site;IPR036397,Ribonuclease H superfamily;IPR001098,DNA-directed DNA polymerase, family A, palm domain;IPR012337,Ribonuclease H-like superfamily;IPR001650,Helicase, C-terminal" "COG1204,Superfamily II helicase;COG0749,DNA polymerase I - 3'-5' exonuclease and polymerase domains;KOG0950,DNA polymerase theta/eta, DEAD-box superfamily" "GO:0003887,molecular_function,DNA-directed DNA polymerase activity;GO:0003677,molecular_function,DNA binding;GO:0071897,biological_process,DNA biosynthetic process;GO:0003676,molecular_function,nucleic acid binding;GO:0006260,biological_process,DNA replication;GO:0006261,biological_process,DNA-dependent DNA replication;GO:0005524,molecular_function,ATP binding" - FAM162A 7.754819172 9.806145674 4.825448362 5.421485987 5.654115872 4.528880766 0.592981638 4.576478715 5.82850075 0.047400933 0.742896758 "K7CLD5,Family with sequence similarity 162, member A" "XP_016797236.1,-" "PF06388,Protein of unknown function (DUF1075)" "IPR009432,Protein of unknown function DUF1075" "ENOG410J1EB,-;ENOG4111YCK,-" "GO:0005829,cellular_component,cytosol;GO:0016021,cellular_component,integral component of membrane;GO:0051402,biological_process,neuron apoptotic process;GO:0090200,biological_process,positive regulation of release of cytochrome c from mitochondria;GO:0005739,cellular_component,mitochondrion;GO:0016020,cellular_component,membrane;GO:0006919,biological_process,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0071456,biological_process,cellular response to hypoxia;GO:0043065,biological_process,positive regulation of apoptotic process" - RAP2B 4.721447216 5.192142222 4.672490156 3.418043865 3.417289788 3.514275532 0.603427295 5.133222605 7.98368484 0.026283081 0.742896758 "G3HL97,Ras-related protein Rap-2b" "XP_003504454.1,-;XP_007620566.1,-" "PF00071,Ras family" "IPR020849,Small GTPase superfamily, Ras type;IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" - "GO:0045121,cellular_component,membrane raft;GO:0061097,biological_process,regulation of protein tyrosine kinase activity;GO:0019003,molecular_function,GDP binding;GO:0070062,cellular_component,extracellular exosome;GO:0005923,cellular_component,bicellular tight junction;GO:0005525,molecular_function,GTP binding;GO:0044291,cellular_component,cell-cell contact zone;GO:0055037,cellular_component,recycling endosome;GO:0070527,biological_process,platelet aggregation;GO:0031954,biological_process,positive regulation of protein autophosphorylation;GO:0019904,molecular_function,protein domain specific binding;GO:0003924,molecular_function,GTPase activity;GO:0032486,biological_process,Rap protein signal transduction;GO:0030168,biological_process,platelet activation;GO:0007165,biological_process,signal transduction;GO:0016020,cellular_component,membrane;GO:0055038,cellular_component,recycling endosome membrane;GO:0005886,cellular_component,plasma membrane;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0030336,biological_process,negative regulation of cell migration" - SKIL 6.284587449 6.06176631 2.535554741 8.203945487 9.13494476 8.718968197 -0.7588823 5.698803888 6.315422336 0.041878424 0.742896758 "H2QNQ5,SKI-like oncogene" "XP_001163447.1,ski-like protein;XP_016797784.1,-;XP_016797783.1,-" "PF02437,SKI/SNO/DAC family;PF08782,c-SKI Smad4 binding domain" "IPR037000,Ski-like, DNA-binding domain superfamily;IPR023216,Transcription regulator SKI/SnoN;IPR014890,c-SKI SMAD4-binding domain;IPR003380,SKI/SNO/DAC domain;IPR010919,SAND-like domain superfamily;IPR028373,Ski-related oncogene Sno;IPR009061,Putative DNA-binding domain superfamily" "ENOG410IFDK,-;ENOG410Y8AU,-" "GO:0048666,biological_process,neuron development;GO:0030514,biological_process,negative regulation of BMP signaling pathway;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0046332,molecular_function,SMAD binding;GO:0030512,biological_process,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0045596,biological_process,negative regulation of cell differentiation" "K18499,ko04550,Signaling pathways regulating pluripotency of stem cells" ZNF721 1.388246897 1.307796968 0.516577685 1.688570073 1.943292623 2.074720184 -0.785017048 3.222860279 5.752996692 0.04950442 0.742896758 "D6RGC2,Zinc finger protein 721" - "PF01352,KRAB box" "IPR013087,Zinc finger C2H2-type;IPR001909,Krueppel-associated box;IPR036051,KRAB domain superfamily;IPR036236,Zinc finger C2H2 superfamily" - "GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0005622,cellular_component,intracellular" - FGFBP1 1.391392106 0.940867938 0.634425001 1.913429829 1.697532638 1.684249554 -0.763908248 0.915103134 6.193275268 0.042560375 0.742896758 "H2QP90,Uncharacterized protein" "XP_009445659.1,fibroblast growth factor-binding protein 1" "PF06473,binding protein 1 (FGF-BP1)" "IPR010510,FGF binding 1" "ENOG4111SHY,-;ENOG410IZBN,-" "GO:0009986,cellular_component,cell surface;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0017134,molecular_function,fibroblast growth factor binding;GO:0005576,cellular_component,extracellular region;GO:0045743,biological_process,positive regulation of fibroblast growth factor receptor signaling pathway" - CLOCK 1.647331072 1.422927912 0.444003494 2.180313063 2.426269939 2.394939118 -0.963343165 4.328925638 5.847815337 0.048129141 0.742896758 "Q3ZCT4,CLOCK protein" "NP_001254772.1,-" "PF14598,PAS domain;PF00010,Helix-loop-helix DNA-binding domain;PF00989,PAS fold" "IPR000014,PAS domain;IPR001067,Nuclear translocator;IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR035965,PAS domain superfamily;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR013767,PAS fold;IPR001610,PAC motif" "ENOG410Y7Z8,-;ENOG410IQ5V,-" "GO:0046983,molecular_function,protein dimerization activity;GO:0003677,molecular_function,DNA binding;GO:0005667,cellular_component,transcription factor complex;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus" "K02223,ko05168,Herpes simplex infection;K02223,ko04711,Circadian rhythm - fly;K02223,ko04728,Dopaminergic synapse;K02223,ko04710,Circadian rhythm" CENPE 4.914104352 5.055430606 2.371043961 10.42193827 8.631101462 15.53295745 -1.440883246 6.181010679 16.61027394 0.005289504 0.742896758 "H2QPZ3,Uncharacterized protein" - "PF00225,Kinesin motor domain" "IPR027640,Kinesin-like protein;IPR019821,Kinesin motor domain, conserved site;IPR001752,Kinesin motor domain;IPR036961,Kinesin motor domain superfamily;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "COG5059,Kinesin-like protein;KOG0242,Kinesin-like protein" "GO:0003777,molecular_function,microtubule motor activity;GO:0005871,cellular_component,kinesin complex;GO:0003774,molecular_function,motor activity;GO:0016887,molecular_function,ATPase activity;GO:0008017,molecular_function,microtubule binding;GO:0007018,biological_process,microtubule-based movement;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding" - ZGRF1 0.405187946 0.333600887 0.211077412 0.558183665 0.463051978 1.175065241 -1.159200967 2.255888021 7.146911152 0.033498895 0.742896758 "G1S333,Zinc finger GRF-type containing 1" - "PF13087,AAA domain;PF13086,AAA domain;PF06839,RF zinc finger;PF10382,Protein of unknown function (DUF2439)" "IPR010666,Zinc finger, GRF-type;IPR018838,Domain of unknown function DUF2439;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "KOG1802,RNA helicase nonsense mRNA reducing factor (pNORF1);COG1112,Superfamily I DNA and RNA helicases and helicase subunits" "GO:0008270,molecular_function,zinc ion binding" - PLK4 2.515702327 2.205850846 1.659842163 3.434378217 2.954837973 7.822093187 -1.092324031 3.939158728 6.428666307 0.040717499 0.742896758 "K7BZR6,Polo-like kinase 4" "XP_016807665.1,-" "PF00069,Protein kinase domain;PF00659,POLO box duplicated region" "IPR033698,Plk4, second cryptic polo-box domain;IPR033696,Plk4, C-terminal polo-box domain;IPR033699,Plk4, first cryptic polo-box domain;IPR011009,Protein kinase-like domain superfamily;IPR017441,Protein kinase, ATP binding site;IPR008266,Tyrosine-protein kinase, active site;IPR033700,Serine/threonine-protein kinase Plk4;IPR000959,POLO box domain;IPR000719,Protein kinase domain" "KOG0575,Polo-like serine/threonine protein kinase;ENOG410XQBP,-" "GO:0046601,biological_process,positive regulation of centriole replication;GO:0001741,cellular_component,XY body;GO:0005730,cellular_component,nucleolus;GO:0060707,biological_process,trophoblast giant cell differentiation;GO:0005813,cellular_component,centrosome;GO:0005814,cellular_component,centriole;GO:0005524,molecular_function,ATP binding;GO:0098535,biological_process,de novo centriole assembly involved in multi-ciliated epithelial cell differentiation;GO:0007099,biological_process,centriole replication;GO:0004674,molecular_function,protein serine/threonine kinase activity;GO:0016301,molecular_function,kinase activity;GO:0005829,cellular_component,cytosol;GO:0098536,cellular_component,deuterosome;GO:0006468,biological_process,protein phosphorylation;GO:0042802,molecular_function,identical protein binding;GO:0016310,biological_process,phosphorylation;GO:0004672,molecular_function,protein kinase activity" "K08863,ko04068,FoxO signaling pathway" SLC7A11 13.69687319 11.04357068 2.776252826 22.95680714 24.39399672 16.87985127 -1.195617084 7.154651668 5.924095181 0.047059219 0.742896758 "H2QQ63,Solute carrier family 7 member 11" "XP_001136486.1,-" "PF13520,Amino acid permease" "IPR002293,Amino acid/polyamine transporter I;IPR004760,L-type amino acid transporter" "COG0531,Amino acid transporters;KOG1287,Amino acid transporters" "GO:0022857,molecular_function,transmembrane transporter activity;GO:0055085,biological_process,transmembrane transport;GO:0015813,biological_process,L-glutamate transmembrane transport;GO:0006865,biological_process,amino acid transport;GO:0015327,molecular_function,cystine:glutamate antiporter activity;GO:0016020,cellular_component,membrane;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane" - NAA15 6.074080469 5.665894294 3.046253458 8.140100122 6.917861105 12.67755652 -0.85692263 6.085598995 6.305440898 0.042156675 0.742896758 "B2RBE5,cDNA, FLJ95468, highly similar to Homo sapiens transcriptional coactivator tubedown-100" "NP_476516.1,N-alpha-acetyltransferase 15, NatA auxiliary subunit" "PF12569,NMDA receptor-regulated protein 1;PF13181,Tetratricopeptide repeat" "IPR021183,N-terminal acetyltransferase A, auxiliary subunit;IPR011990,Tetratricopeptide-like helical domain superfamily;IPR019734,Tetratricopeptide repeat;IPR013026,Tetratricopeptide repeat-containing domain" "KOG1156,N-terminal acetyltransferase;ENOG410XR7D,-" - - USP38 0.356747353 0.372386257 0.164499609 0.545043185 0.640059643 0.483106007 -0.836655999 1.720563089 7.991238643 0.026357753 0.742896758 "K7CJ23,Ubiquitin specific peptidase 38" - "PF00443,Ubiquitin carboxyl-terminal hydrolase" "IPR018200,Ubiquitin specific protease, conserved site;IPR028889,Ubiquitin specific protease domain;IPR033840,Ubiquitin-specific peptidase 38;IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase" "KOG1864,Ubiquitin-specific protease;ENOG410XQ81,-" "GO:0006511,biological_process,ubiquitin-dependent protein catabolic process;GO:0036459,molecular_function,thiol-dependent ubiquitinyl hydrolase activity;GO:0016579,biological_process,protein deubiquitination" - TDO2 0.18182431 0.169164343 0.084234175 0.289578984 0.248882593 0.37885351 -1.01822423 0.283054694 7.58366383 0.029095173 0.742896758 "H2QQC2,Tryptophan 2,3-dioxygenase" "XP_001140187.1,tryptophan 2,3-dioxygenase isoform X1" "PF03301,Tryptophan 2,3-dioxygenase" "IPR004981,Tryptophan 2,3-dioxygenase;IPR037217,Tryptophan/Indoleamine 2,3-dioxygenase-like" "COG3483,Tryptophan 2,3-dioxygenase (vermilion);KOG3906,Tryptophan 2,3-dioxygenase" "GO:0051213,molecular_function,dioxygenase activity;GO:0004833,molecular_function,tryptophan 2,3-dioxygenase activity;GO:0016491,molecular_function,oxidoreductase activity;GO:0046872,molecular_function,metal ion binding;GO:0051289,biological_process,protein homotetramerization;GO:0006569,biological_process,tryptophan catabolic process;GO:0019441,biological_process,tryptophan catabolic process to kynurenine;GO:0019442,biological_process,tryptophan catabolic process to acetyl-CoA;GO:0055114,biological_process,oxidation-reduction process;GO:0020037,molecular_function,heme binding;GO:0042802,molecular_function,identical protein binding" "K00453,ko00380,Tryptophan metabolism" NPY5R 0.425605607 0.402402074 0.209585798 0.753811839 0.856761383 0.537119902 -0.971664594 0.809303823 9.070156908 0.020242503 0.742896758 "G3QP85,Neuropeptide Y receptor Y5" "XP_018881488.1,-;XP_018881487.1,-;XP_004040628.1,-" "PF00001,7 transmembrane receptor (rhodopsin family)" "IPR000611,Neuropeptide Y receptor family;IPR017452,GPCR, rhodopsin-like, 7TM;IPR000393,Neuropeptide Y5 receptor;IPR000276,G protein-coupled receptor, rhodopsin-like" - "GO:0001602,molecular_function,pancreatic polypeptide receptor activity;GO:0007268,biological_process,chemical synaptic transmission;GO:0001601,molecular_function,peptide YY receptor activity;GO:0003151,biological_process,outflow tract morphogenesis;GO:0003214,biological_process,cardiac left ventricle morphogenesis;GO:0007218,biological_process,neuropeptide signaling pathway;GO:0016021,cellular_component,integral component of membrane;GO:0004983,molecular_function,neuropeptide Y receptor activity;GO:0007186,biological_process,G-protein coupled receptor signaling pathway;GO:0004930,molecular_function,G-protein coupled receptor activity;GO:0016020,cellular_component,membrane;GO:0043005,cellular_component,neuron projection" "K04207,ko04080,Neuroactive ligand-receptor interaction" C5orf38 0.545714826 0.723534427 0.767807267 0.279482433 0.325495147 0.282543312 1.322520546 0.019387339 13.10402181 0.008902842 0.742896758 "H2R5Q2,Uncharacterized protein" "XP_009447044.1,protein CEI isoform X1" - - "ENOG4111ECT,-;ENOG410J8BP,-" - - TARS 27.48833509 26.26696026 13.72566269 36.25058825 35.89241476 40.04549908 -0.673447409 7.39430928 6.314341022 0.04109807 0.742896758 "G3RZ96,Threonyl-tRNA synthetase" - "PF02824,TGS domain;PF03129,Anticodon binding domain;PF00587,tRNA synthetase class II core domain (G, H, P, S and T);PF07973,Threonyl and Alanyl tRNA synthetase second additional domain" "IPR004095,TGS;IPR004154,Anticodon-binding;IPR002320,Threonine-tRNA ligase, class IIa;IPR006195,Aminoacyl-tRNA synthetase, class II;IPR036621,Anticodon-binding domain superfamily;IPR012675,Beta-grasp domain superfamily;IPR002314,Aminoacyl-tRNA synthetase, class II (G/ P/ S/T);IPR012947,Threonyl/alanyl tRNA synthetase, SAD;IPR033728,Threonine-tRNA ligase catalytic core domain;IPR018163,Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily;IPR012676,TGS-like" - "GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005737,cellular_component,cytoplasm;GO:0015629,cellular_component,actin cytoskeleton;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0004829,molecular_function,threonine-tRNA ligase activity;GO:0006435,biological_process,threonyl-tRNA aminoacylation;GO:0043039,biological_process,tRNA aminoacylation;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0005524,molecular_function,ATP binding" - C5orf34 0.666763271 0.750731326 0.449970078 1.062149787 0.90805687 1.791309898 -0.94630008 1.50976877 7.109693769 0.033829479 0.742896758 "H2QZL0,Uncharacterized protein" "XP_001135314.1,uncharacterized protein C5orf34 homolog isoform X1" "PF15025,omain of unknown function (DUF4524);PF15016,omain of unknown function (DUF4520)" "IPR027865,Domain of unknown function DUF4520;IPR027830,Domain of unknown function DUF4524" "ENOG410IJYP,-;ENOG410YJ0T,-" - - MIER3 2.475007752 2.476232941 1.162658005 3.288163335 3.276555131 3.64138745 -0.683908755 3.947273811 6.410406051 0.040236699 0.742896758 "G3RGV9,MIER family member 3" "XP_018869175.1,-" "PF01448,LM2 domain;PF00249,Myb-like DNA-binding domain" "IPR031156,Mesoderm induction early response protein 3;IPR009057,Homeobox-like domain superfamily;IPR017884,SANT domain;IPR000949,ELM2 domain;IPR001005,SANT/Myb domain" - "GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus" - FAM169A 1.864835018 1.85724921 0.614049944 2.66649056 2.652951518 3.775953511 -1.038635994 3.91247028 7.053697072 0.034335012 0.742896758 "H2QR33,Uncharacterized protein" "XP_009447295.1,-;XP_009447296.1,-;XP_517703.5,-" - "IPR029623,Soluble lamin-associated protein of 75kDa;IPR029625,Protein FAM169" "ENOG410ZN43,-;ENOG410IK9K,-" - - HOMER1 2.135673584 2.003532386 1.52910593 2.991823467 2.762926998 4.102345397 -0.717843234 3.985151325 7.944617759 0.026541624 0.742896758 "G1RQW5,Homer scaffolding protein 1" "XP_003261566.1,homer protein homolog 1 isoform X1" "PF00568,WH1 domain" "IPR011993,PH-like domain superfamily;IPR000697,WH1/EVH1 domain" "ENOG410IGRQ,-;ENOG410XQWT,-" - "K15010,ko04068,FoxO signaling pathway;K15010,ko04724,Glutamatergic synapse" POLR3G 4.083394051 3.266705152 4.094398956 6.343716542 5.47789948 10.70807693 -0.868908302 4.512595128 5.81488422 0.048600988 0.742896758 "A0A024RAM1,Polymerase" "XP_005248461.1,-;XP_011541404.1,-;XP_011541403.1,-;NP_006458.2,DNA-directed RNA polymerase III subunit RPC7;XP_016864446.1,-;XP_011541402.1,-" "PF11705,NA-directed RNA polymerase III subunit Rpc31" "IPR024661,DNA-directed RNA polymerase III, subunit Rpc31" "ENOG4112311,-;ENOG410IKHU,-" "GO:0000790,cellular_component,nuclear chromatin;GO:0008283,biological_process,cell proliferation;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0006383,biological_process,transcription by RNA polymerase III" "K03024,ko04623,Cytosolic DNA-sensing pathway;K03024,ko05169,Epstein-Barr virus infection;K03024,ko00240,Pyrimidine metabolism;K03024,ko00230,Purine metabolism;K03024,ko03020,RNA polymerase" SLF1 1.16966017 1.131314424 0.822841469 1.69725124 1.573679565 3.040568455 -0.943402426 3.492892598 8.042843985 0.026678585 0.742896758 "B4DR33,cDNA FLJ57334, highly similar to Ankyrin repeat domain-containing protein 32" - "PF12796,Ankyrin repeats (3 copies);PF16770,Regulator of Ty1 transposition protein 107 BRCT domain" "IPR020683,Ankyrin repeat-containing domain;IPR036420,BRCT domain superfamily;IPR002110,Ankyrin repeat;IPR001357,BRCT domain;IPR036770,Ankyrin repeat-containing domain superfamily" "KOG0504,FOG: Ankyrin repeat;ENOG410XPFH,-;KOG1929,Nucleotide excision repair factor NEF2, RAD4/CUT5 component" - - ZRSR1 5.134945643 4.640268117 1.825817838 7.82511833 7.643688339 8.710028097 -1.016880894 3.291207626 9.381775337 0.019518094 0.742896758 "H2QRB8,Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1" - "PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain);PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar)" "IPR009145,U2 auxiliary factor small subunit;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR000504,RNA recognition motif domain;IPR000571,Zinc finger, CCCH-type;IPR035979,RNA-binding domain superfamily;IPR003954,RNA recognition motif domain, eukaryote" "KOG2202,U2 snRNP splicing factor, small subunit, and related proteins;ENOG410Z5PX,-" "GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0003723,molecular_function,RNA binding;GO:0005681,cellular_component,spliceosomal complex;GO:0089701,cellular_component,U2AF;GO:0000398,biological_process,mRNA splicing, via spliceosome;GO:0030628,molecular_function,pre-mRNA 3'-splice site binding" - SRFBP1 4.374742714 3.655017247 1.955818923 5.687670643 5.328138979 5.958786382 -0.707528642 3.782859785 7.002377124 0.034099518 0.742896758 "G3QXL0,Serum response factor binding protein 1" "XP_004042451.1,serum response factor-binding protein 1" "PF09073,BUD22" "IPR037393,Bud22/Serum response factor-binding protein 1;IPR015158,Bud22 domain" - - - IRF1 3.220752287 3.387306828 3.645008874 2.609882382 2.570906662 2.002095666 0.641656302 4.525615957 6.785468648 0.035996344 0.742896758 "Q6FHN8,IRF1 protein" "NP_002189.1,interferon regulatory factor 1 isoform 1" "PF00605,Interferon regulatory factor transcription factor" "IPR019817,Interferon regulatory factor, conserved site;IPR036388,Winged helix-like DNA-binding domain superfamily;IPR031215,Interferon regulatory factor 1;IPR017431,Interferon regulatory factor-1/2;IPR036390,Winged helix DNA-binding domain superfamily;IPR001346,Interferon regulatory factor DNA-binding domain" "ENOG410IER3,-;ENOG4111HM7,-" "GO:0051607,biological_process,defense response to virus;GO:0032481,biological_process,positive regulation of type I interferon production;GO:0034124,biological_process,regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0043374,biological_process,CD8-positive, alpha-beta T cell differentiation;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0006351,biological_process,transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0005737,cellular_component,cytoplasm;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045893,biological_process,positive regulation of transcription, DNA-templated;GO:0060333,biological_process,interferon-gamma-mediated signaling pathway;GO:0006915,biological_process,apoptotic process;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0050776,biological_process,regulation of immune response;GO:0045084,biological_process,positive regulation of interleukin-12 biosynthetic process;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0010468,biological_process,regulation of gene expression;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:2000564,biological_process,regulation of CD8-positive, alpha-beta T cell proliferation;GO:0008285,biological_process,negative regulation of cell proliferation;GO:0045590,biological_process,negative regulation of regulatory T cell differentiation" "K09444,ko04917,Prolactin signaling pathway;K09444,ko05160,Hepatitis C;K09444,ko05133,Pertussis" EGR1 0.342206981 0.407469575 0.078501646 46.29094791 57.35192336 0.917181541 -6.905090694 5.700539273 20.6587426 0.003041678 0.742896758 "G3QYK0,Early growth response protein" - "PF00096,Zinc finger, C2H2 type;PF11914,omain of unknown function (DUF3432);PF11928,omain of unknown function (DUF3446)" - - - - RELL2 2.868599827 3.052002504 2.505133878 1.738541265 2.3697451 1.719752946 0.636148701 2.643258784 7.643048332 0.028653648 0.742896758 "G3RJT5,RELT like 2" "XP_018883544.1,-;XP_004042750.1,RELT-like protein 2;XP_018883543.1,-;XP_018883545.1,-;XP_018883542.1,-" "PF12606,Tumour necrosis factor receptor superfamily member 19" "IPR022248,TNF receptor family, RELT" - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - PPARGC1B 0.354993843 0.352528272 0.175832967 0.540318007 0.563473541 0.53978856 -0.832271084 2.424190825 10.36746712 0.01519335 0.742896758 "H2QRS1,Uncharacterized protein" - "PF00076,RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)" "IPR034621,Peroxisome proliferator-activated receptor gamma coactivator 1-beta;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR034177,PPARGC1B, RNA recognition motif;IPR000504,RNA recognition motif domain;IPR034605,PGC-1;IPR035979,RNA-binding domain superfamily" "ENOG410IIJJ,-;ENOG4111PZ5,-" "GO:0030331,molecular_function,estrogen receptor binding;GO:0003712,molecular_function,transcription cofactor activity;GO:0003676,molecular_function,nucleic acid binding;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0003723,molecular_function,RNA binding;GO:0008134,molecular_function,transcription factor binding;GO:0051091,biological_process,positive regulation of DNA binding transcription factor activity;GO:0001104,molecular_function,RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component,nucleus;GO:0030374,molecular_function,ligand-dependent nuclear receptor transcription coactivator activity" "K17962,ko04931,Insulin resistance" SLC26A2 1.171834765 1.191255992 0.426497636 2.111616182 1.750680528 1.864388605 -0.993810818 3.579297929 8.652624654 0.023051691 0.742896758 "H2QRS4,Sulfate transporter" "XP_016809513.1,sulfate transporter isoform X2" "PF00916,Sulfate permease family;PF01740,STAS domain" "IPR030280,Solute carrier family 26 member 2;IPR002645,STAS domain;IPR018045,Sulphate anion transporter, conserved site;IPR001902,SLC26A/SulP transporter;IPR036513,STAS domain superfamily;IPR011547,SLC26A/SulP transporter domain" "KOG0236,Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family);COG0659,Sulfate permease and related transporters (MFS superfamily)" "GO:0019531,molecular_function,oxalate transmembrane transporter activity;GO:1902358,biological_process,sulfate transmembrane transport;GO:0001503,biological_process,ossification;GO:1902476,biological_process,chloride transmembrane transport;GO:0055085,biological_process,transmembrane transport;GO:0008271,molecular_function,secondary active sulfate transmembrane transporter activity;GO:0008272,biological_process,sulfate transport;GO:0019532,biological_process,oxalate transport;GO:0051453,biological_process,regulation of intracellular pH;GO:0006811,biological_process,ion transport;GO:0015701,biological_process,bicarbonate transport;GO:0015106,molecular_function,bicarbonate transmembrane transporter activity;GO:0015116,molecular_function,sulfate transmembrane transporter activity;GO:0016020,cellular_component,membrane;GO:0005254,molecular_function,chloride channel activity;GO:0015301,molecular_function,anion:anion antiporter activity;GO:0005887,cellular_component,integral component of plasma membrane;GO:0016021,cellular_component,integral component of membrane;GO:0042391,biological_process,regulation of membrane potential" - TNIP1 87.97394635 98.43783816 85.28496861 69.31813768 67.87118837 41.75689466 0.719334654 8.775702487 6.681676954 0.037045693 0.742896758 "A8K4N4,cDNA FLJ77844, highly similar to Homo sapiens TNFAIP3 interacting protein 1, mRNA" "NP_001239319.1,-" - "IPR033372,TNFAIP3-interacting protein 1" "ENOG411180D,-;ENOG410IEGE,-" "GO:0070373,biological_process,negative regulation of ERK1 and ERK2 cascade;GO:0002755,biological_process,MyD88-dependent toll-like receptor signaling pathway;GO:0043124,biological_process,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050727,biological_process,regulation of inflammatory response" - NIPAL4 0.199715027 0.27130286 0.327826455 0.085235058 0.108292112 0.161566028 1.2824967 -0.171308809 7.739158602 0.028490465 0.742896758 "G3RE29,NIPA like domain containing 4" - "PF05653,Magnesium transporter NIPA" "IPR008521,Magnesium transporter NIPA" - "GO:0015095,molecular_function,magnesium ion transmembrane transporter activity;GO:1903830,biological_process,magnesium ion transmembrane transport;GO:0015693,biological_process,magnesium ion transport;GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - DUSP1 24.9632023 25.16250043 13.68952059 74.83376315 95.69783027 31.56338127 -1.576959965 6.435252028 14.19981955 0.007735168 0.742896758 "G3QW32,Dual specificity protein phosphatase" "XP_004043046.1,-" "PF00581,Rhodanese-like domain;PF00782,ual specificity phosphatase, catalytic domain" "IPR008343,Mitogen-activated protein (MAP) kinase phosphatase;IPR036873,Rhodanese-like domain superfamily;IPR029021,Protein-tyrosine phosphatase-like;IPR000387,Tyrosine specific protein phosphatases domain;IPR000340,Dual specificity phosphatase, catalytic domain;IPR003595,Protein-tyrosine phosphatase, catalytic;IPR001763,Rhodanese-like domain;IPR020422,Dual specificity protein phosphatase domain;IPR016130,Protein-tyrosine phosphatase, active site;IPR020417,Atypical dual specificity phosphatase;IPR024950,Dual specificity phosphatase" - "GO:0008138,molecular_function,protein tyrosine/serine/threonine phosphatase activity;GO:0004725,molecular_function,protein tyrosine phosphatase activity;GO:0004721,molecular_function,phosphoprotein phosphatase activity;GO:0035335,biological_process,peptidyl-tyrosine dephosphorylation;GO:0000188,biological_process,inactivation of MAPK activity;GO:0006470,biological_process,protein dephosphorylation;GO:0017017,molecular_function,MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016787,molecular_function,hydrolase activity;GO:0016311,biological_process,dephosphorylation;GO:0016791,molecular_function,phosphatase activity" - N4BP3 0.380115508 0.518245579 0.299819477 0.22121862 0.318535547 0.201277257 0.782422592 1.009313332 6.644686356 0.037429351 0.742896758 "H2R543,Uncharacterized protein" "XP_016809870.1,-;XP_016809869.1,-;XP_016809867.1,NEDD4-binding protein 3;XP_016809868.1,-" "PF06818,ez1" "IPR033571,NEDD4-binding protein 3" "ENOG410XQRF,-;ENOG410IE8K,-" - - PXDC1 5.746475643 6.718801074 8.015449579 4.071392288 5.295545542 3.554156559 0.807551754 3.820478664 7.181020808 0.033170191 0.742896758 "G3QDX5,PX domain containing 1" "XP_004043257.1,PX domain-containing protein 1" "PF00787,PX domain" "IPR036871,PX domain superfamily;IPR001683,Phox homologous domain" - "GO:0035091,molecular_function,phosphatidylinositol binding" - HLA-A 93.76550898 96.44561592 109.997717 66.660399 72.21097827 40.77546572 0.879075523 7.785952868 7.853332704 0.027616805 0.742896758 "Q5SRN5,HLA class I histocompatibility antigen, A-3 alpha chain" - "PF07654,Immunoglobulin C1-set domain;PF06623,MHC_I C-terminus;PF00129,Class I Histocompatibility antigen, domains alpha 1 and 2" "IPR003006,Immunoglobulin/major histocompatibility complex, conserved site;IPR001039,MHC class I alpha chain, alpha1 alpha2 domains;IPR010579,MHC class I, alpha chain, C-terminal;IPR036179,Immunoglobulin-like domain superfamily;IPR013783,Immunoglobulin-like fold;IPR007110,Immunoglobulin-like domain;IPR011161,MHC class I-like antigen recognition-like;IPR003597,Immunoglobulin C1-set;IPR037055,MHC class I-like antigen recognition-like superfamily;IPR011162,MHC classes I/II-like antigen recognition protein" "ENOG410II5V,-;ENOG4111K8F,-" "GO:0019882,biological_process,antigen processing and presentation;GO:0042612,cellular_component,MHC class I protein complex;GO:0006955,biological_process,immune response;GO:0002474,biological_process,antigen processing and presentation of peptide antigen via MHC class I;GO:0016020,cellular_component,membrane;GO:0002376,biological_process,immune system process;GO:0016021,cellular_component,integral component of membrane" - PPP1R18 24.5677806 26.17908485 24.09818228 15.72118227 17.93443581 15.30532535 0.724530568 6.584417317 10.1796243 0.015813987 0.742896758 "A0A1U9X8D3,PPP1R18" - - "IPR026671,Phostensin/Taperin;IPR025907,Phostensin/Taperin PP1-binding domain;IPR025903,Phostensin/Taperin N-terminal domain" - "GO:0019902,molecular_function,phosphatase binding" - NFKBIL1 6.521754005 7.68795749 10.20524044 4.687496962 5.683357508 3.464954053 0.974831375 3.550638919 8.101488469 0.026298549 0.742896758 "Q5ST97,IKBL protein" - "PF13637,Ankyrin repeats (many copies)" "IPR020683,Ankyrin repeat-containing domain;IPR036770,Ankyrin repeat-containing domain superfamily" "ENOG4111NZ2,-;ENOG410IZ7E,-" - - DDAH2 7.983844696 8.600552941 10.36600315 6.689127315 5.711875537 6.170082253 0.670683271 4.30068469 5.9884935 0.045554286 0.742896758 "U3E282,N" "XP_008992418.1,-;XP_008992417.1,-;XP_002746399.1,-" - "IPR033202,N(G),N(G)-dimethylarginine dimethylaminohydrolase 2;IPR033199,Dimethylarginine dimethylaminohydrolase/arginine deiminase" "ENOG4111YMV,-;ENOG410ISNS,-" "GO:0045429,biological_process,positive regulation of nitric oxide biosynthetic process;GO:0016403,molecular_function,dimethylargininase activity;GO:0006527,biological_process,arginine catabolic process;GO:0016787,molecular_function,hydrolase activity;GO:0000052,biological_process,citrulline metabolic process" - RAB23 2.341081399 2.141448661 1.435222356 3.155162127 3.185735846 3.073169958 -0.590510042 3.63883677 8.022941421 0.026026587 0.742896758 "A0A024RD41,RAB23, member RAS oncogene family, isoform CRA_a" "NP_001265595.1,-;NP_057361.3,ras-related protein Rab-23;NP_001265597.1,-;NP_899050.1,-;NP_001265596.1,-" "PF00071,Ras family" "IPR034114,Ras-related protein Rab-23;IPR001806,Small GTPase superfamily;IPR005225,Small GTP-binding protein domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "KOG4252,GTP-binding protein;ENOG4110BDM,-" "GO:0030054,cellular_component,cell junction;GO:0005525,molecular_function,GTP binding;GO:0005886,cellular_component,plasma membrane;GO:0005813,cellular_component,centrosome;GO:0003924,molecular_function,GTPase activity;GO:0005829,cellular_component,cytosol" - LIN28B 1.236844499 0.958660092 0.229839007 2.116438645 1.779458433 1.948310785 -1.247920553 3.011859735 6.378660877 0.041293582 0.742896758 "A0A1B0GVD3,Protein lin-28 homolog B" "XP_011534120.1,protein lin-28 homolog B isoform X2" "PF00313,'Cold-shock' DNA-binding domain;PF00098,Zinc knuckle" "IPR001878,Zinc finger, CCHC-type;IPR002059,Cold-shock protein, DNA-binding;IPR036875,Zinc finger, CCHC-type superfamily;IPR011129,Cold shock domain;IPR012340,Nucleic acid-binding, OB-fold" - "GO:0003677,molecular_function,DNA binding;GO:0005730,cellular_component,nucleolus;GO:0003676,molecular_function,nucleic acid binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding" - ZBTB24 1.78076116 1.944453505 0.892691302 2.691588963 2.626696886 3.375327731 -0.858987534 3.593336592 9.045584451 0.020769628 0.742896758 "H2QTJ2,Zinc finger and BTB domain containing 24" "XP_016811622.1,zinc finger and BTB domain-containing protein 24 isoform X1" "PF00096,Zinc finger, C2H2 type;PF00651,BTB/POZ domain" "IPR013087,Zinc finger C2H2-type;IPR011333,SKP1/BTB/POZ domain superfamily;IPR000210,BTB/POZ domain;IPR036236,Zinc finger C2H2 superfamily" "KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger" "GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0003676,molecular_function,nucleic acid binding" - CTGF 5.519234954 4.617331098 2.053695687 10.84901257 13.73508808 4.640981269 -1.193245961 3.967536615 7.017555233 0.03466659 0.742896758 "Q5M8T4,Connective tissue growth factor" "NP_001892.1,connective tissue growth factor precursor" "PF00093,von Willebrand factor type C domain;PF00090,Thrombospondin type 1 domain;PF00007,Cystine-knot domain;PF00219,Insulin-like growth factor binding protein" "IPR012395,IGFBP-related, CNN;IPR000867,Insulin-like growth factor-binding protein, IGFBP;IPR000884,Thrombospondin type-1 (TSP1) repeat;IPR017891,Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site;IPR009030,Growth factor receptor cysteine-rich domain superfamily;IPR006207,Cystine knot, C-terminal;IPR001007,VWFC domain;IPR006208,Glycoprotein hormone subunit beta;IPR036383,Thrombospondin type-1 (TSP1) repeat superfamily" "ENOG4111F77,-;ENOG410IH0W,-" "GO:0001558,biological_process,regulation of cell growth;GO:0005520,molecular_function,insulin-like growth factor binding;GO:0005576,cellular_component,extracellular region" "K06827,ko04390,Hippo signaling pathway" RP3-468K18.5 30.39069792 27.92679133 15.93762667 36.75338666 35.58234351 51.03484924 -0.673587384 4.632001458 5.849102932 0.047628713 0.742896758 - - - - - - - ULBP1 0.579525293 0.719430943 0.344967513 1.217633346 1.749458719 0.800610575 -1.112391286 1.487565771 9.813994515 0.017754289 0.742896758 "H2QZY1,UL16 binding protein 1" "XP_001134754.1,NKG2D ligand 1 isoform X1" "PF00129,Class I Histocompatibility antigen, domains alpha 1 and 2" "IPR011161,MHC class I-like antigen recognition-like;IPR037055,MHC class I-like antigen recognition-like superfamily;IPR011162,MHC classes I/II-like antigen recognition protein" "ENOG410J4VC,-;ENOG41113ZC,-" "GO:0030101,biological_process,natural killer cell activation;GO:0015629,cellular_component,actin cytoskeleton;GO:0042267,biological_process,natural killer cell mediated cytotoxicity;GO:0005886,cellular_component,plasma membrane;GO:0016020,cellular_component,membrane;GO:0046658,cellular_component,anchored component of plasma membrane;GO:0005829,cellular_component,cytosol;GO:0046703,molecular_function,natural killer cell lectin-like receptor binding;GO:0016021,cellular_component,integral component of membrane" "K07986,ko04650,Natural killer cell mediated cytotoxicity" RP11-514O12.4 4.124189268 4.109912767 6.774299529 2.440942638 3.560103171 2.304003363 1.015311053 1.29915571 6.435257383 0.04064236 0.742896758 "H0YAE9,Uncharacterized protein" - "PF00445,Ribonuclease T2 family" "IPR036430,Ribonuclease T2-like superfamily;IPR033697,Ribonuclease T2, eukaryotic;IPR001568,Ribonuclease T2-like;IPR033130,Ribonuclease T2, His active site 2;IPR018188,Ribonuclease T2, His active site 1" "ENOG4111M7G,-;KOG1642,Ribonuclease, T2 family" "GO:0003723,molecular_function,RNA binding;GO:0033897,molecular_function,ribonuclease T2 activity;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic" - RNASET2 1.405005243 1.416036934 1.563182126 0.930734562 1.039663781 0.610812456 0.897416844 3.181106958 9.976068211 0.016809837 0.742896758 "A0A087WZM2,Ribonuclease T2" - "PF00445,Ribonuclease T2 family" "IPR036430,Ribonuclease T2-like superfamily;IPR033697,Ribonuclease T2, eukaryotic;IPR001568,Ribonuclease T2-like;IPR033130,Ribonuclease T2, His active site 2;IPR018188,Ribonuclease T2, His active site 1" - "GO:0003723,molecular_function,RNA binding;GO:0033897,molecular_function,ribonuclease T2 activity;GO:0090502,biological_process,RNA phosphodiester bond hydrolysis, endonucleolytic" - PDGFA 12.23742746 14.42248357 11.25167816 6.99884339 7.890375614 7.277495408 0.874962859 5.391545535 17.27613206 0.004512961 0.742896758 "A8K852,cDNA FLJ75285, highly similar to Homo sapiens platelet-derived growth factor alpha polypeptide" - "PF04692,Platelet-derived growth factor, N terminal region;PF00341,PDGF/VEGF domain" "IPR023581,Platelet-derived growth factor, conserved site;IPR000072,PDGF/VEGF domain;IPR006782,Platelet-derived growth factor, N-terminal;IPR029034,Cystine-knot cytokine" "ENOG4111GMH,-;ENOG410IEXJ,-" "GO:0008083,molecular_function,growth factor activity;GO:0010469,biological_process,regulation of signaling receptor activity;GO:0016020,cellular_component,membrane" - PRKAR1B 8.87827891 9.354807753 14.82636516 6.502258824 6.354439328 7.347216611 0.86559542 5.36931489 5.862860683 0.047915583 0.742896758 "G3R8D7,Protein kinase cAMP-dependent type I regulatory subunit beta" "XP_004045042.1,-;XP_004045043.1,-" "PF00027,Cyclic nucleotide-binding domain;PF02197,Regulatory subunit of type II PKA R-subunit" "IPR003117,cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain;IPR014710,RmlC-like jelly roll fold;IPR018488,Cyclic nucleotide-binding, conserved site;IPR000595,Cyclic nucleotide-binding domain;IPR018490,Cyclic nucleotide-binding-like;IPR012198,cAMP-dependent protein kinase regulatory subunit" - "GO:0034236,molecular_function,protein kinase A catalytic subunit binding;GO:0001932,biological_process,regulation of protein phosphorylation;GO:0004862,molecular_function,cAMP-dependent protein kinase inhibitor activity;GO:0007611,biological_process,learning or memory;GO:0005952,cellular_component,cAMP-dependent protein kinase complex;GO:2000480,biological_process,negative regulation of cAMP-dependent protein kinase activity;GO:0000166,molecular_function,nucleotide binding;GO:0008603,molecular_function,cAMP-dependent protein kinase regulator activity;GO:0030552,molecular_function,cAMP binding" "K04739,ko04910,Insulin signaling pathway" TWIST1 2.755864345 2.774084422 3.114063371 1.82304358 1.709129707 1.738968614 0.836676755 2.279188308 10.82020587 0.013822525 0.742896758 "A0A218VF78,Twist-related protein 1" - - "IPR011598,Myc-type, basic helix-loop-helix (bHLH) domain;IPR036638,Helix-loop-helix DNA-binding domain superfamily;IPR015789,Twist-related" - "GO:0046983,molecular_function,protein dimerization activity" - TWISTNB 5.589355879 5.295484301 2.446741341 7.657350957 8.03762097 9.21915076 -0.85097239 4.644533134 8.828445402 0.021912907 0.742896758 "H2QU84,TWIST neighbor" "XP_519541.3,DNA-directed RNA polymerase I subunit RPA43" "PF03876,SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397" "IPR005576,RNA polymerase Rpb7, N-terminal;IPR036898,RNA polymerase Rpb7-like, N-terminal domain superfamily" "KOG4134,DNA-dependent RNA polymerase I;ENOG4111JD4,-" "GO:0005736,cellular_component,DNA-directed RNA polymerase I complex;GO:0001054,molecular_function,RNA polymerase I activity;GO:0006360,biological_process,transcription by RNA polymerase I;GO:0003899,molecular_function,DNA-directed 5'-3' RNA polymerase activity;GO:0006351,biological_process,transcription, DNA-templated" "K03004,ko00230,Purine metabolism;K03004,ko03020,RNA polymerase;K03004,ko00240,Pyrimidine metabolism" PRR15 13.89832074 16.2894289 17.02741098 10.49586735 9.584616812 9.833300816 0.783375486 4.70052392 9.878555191 0.016879348 0.742896758 "A4D1A1,Proline rich 15" "NP_001316925.1,-;NP_787083.1,proline-rich protein 15;XP_011513501.1,-;XP_011513500.1,-;NP_001316926.1,-" "PF15321,ATPase family AAA domain containing 4" "IPR028237,Proline-rich protein 15" "ENOG410J434,-;ENOG410Y7UI,-" - - PCOLCE 0.799739687 0.775747974 0.606778605 0.583903583 0.516073846 0.340063248 0.70259931 1.127312897 6.121574087 0.043458733 0.742896758 "A4D2D2,Procollagen C-endopeptidase enhancer" - "PF00431,CUB domain;PF01759,UNC-6/NTR/C345C module" "IPR008993,Tissue inhibitor of metalloproteinases-like, OB-fold;IPR035914,Spermadhesin, CUB domain superfamily;IPR001134,Netrin domain;IPR000859,CUB domain;IPR035814,Procollagen C-endopeptidase enhancer, NTR domain;IPR018933,Netrin module, non-TIMP type;IPR028870,Procollagen C-endopeptidase enhancer 1" "ENOG410IPS8,-;ENOG410Y9AW,-" "GO:0005581,cellular_component,collagen trimer;GO:0005518,molecular_function,collagen binding;GO:0016504,molecular_function,peptidase activator activity;GO:0010952,biological_process,positive regulation of peptidase activity;GO:0008201,molecular_function,heparin binding;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space" - HILPDA 20.88596807 30.73058768 8.960997006 8.706822898 7.746234146 5.484940294 1.514074576 4.810614952 14.84834169 0.006952551 0.742896758 "H2QVB8,Chromosome 7 open reading frame 68" "XP_003951175.1,-;XP_003951174.1,-" "PF15220,Hypoxia-inducible lipid droplet-associated" "IPR026190,Hypoxia-inducible lipid droplet-associated protein" "ENOG41114TU,-;ENOG410JJ0P,-" "GO:0005811,cellular_component,lipid droplet;GO:0009986,cellular_component,cell surface;GO:0071456,biological_process,cellular response to hypoxia;GO:0010884,biological_process,positive regulation of lipid storage;GO:0005102,molecular_function,signaling receptor binding;GO:0008284,biological_process,positive regulation of cell proliferation;GO:0001819,biological_process,positive regulation of cytokine production;GO:0016020,cellular_component,membrane;GO:0035425,biological_process,autocrine signaling;GO:0005615,cellular_component,extracellular space;GO:0030141,cellular_component,secretory granule;GO:0016021,cellular_component,integral component of membrane;GO:0005654,cellular_component,nucleoplasm" - TMEM209 0.824095514 0.973958455 0.393395682 1.274949777 1.208894038 1.409550144 -0.776536943 2.256755595 6.603288312 0.038414654 0.742896758 "A0A140VJX5,Testicular tissue protein Li 202" "NP_116231.2,transmembrane protein 209 isoform 1" "PF09786,Cytochrome B561, N terminal" "IPR019176,Cytochrome B561-related" - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - XRCC2 1.952988631 1.943121062 1.096415487 3.33811842 2.57049279 7.027983491 -1.32583739 3.847453242 9.022004203 0.021165359 0.742896758 "H2R1S2,X-ray repair complementing defective repair in Chinese hamster cells 2" "XP_001140134.1,DNA repair protein XRCC2;XP_016813952.1,-" "PF08423,Rad51" "IPR013632,DNA recombination and repair protein Rad51-like, C-terminal;IPR030547,DNA repair protein XRCC2;IPR020588,DNA recombination and repair protein RecA-like, ATP-binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "ENOG4112B2N,-;KOG2859,DNA repair protein, member of the recA/RAD51 family" "GO:0003697,molecular_function,single-stranded DNA binding;GO:0000400,molecular_function,four-way junction DNA binding;GO:0005657,cellular_component,replication fork;GO:0004520,molecular_function,endodeoxyribonuclease activity;GO:0006312,biological_process,mitotic recombination;GO:0003677,molecular_function,DNA binding;GO:0008094,molecular_function,DNA-dependent ATPase activity;GO:0003690,molecular_function,double-stranded DNA binding;GO:0000150,molecular_function,recombinase activity;GO:0000707,biological_process,meiotic DNA recombinase assembly;GO:0042148,biological_process,strand invasion;GO:0010212,biological_process,response to ionizing radiation;GO:0033063,cellular_component,Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0007131,biological_process,reciprocal meiotic recombination;GO:0006281,biological_process,DNA repair;GO:0005524,molecular_function,ATP binding;GO:0000724,biological_process,double-strand break repair via homologous recombination" "K10879,ko03440,Homologous recombination" MNX1 1.466668119 1.021555344 1.242829389 1.010055041 0.725237581 0.765837839 0.69161516 2.158948423 6.102524648 0.043783576 0.742896758 "H2R4U3,Motor neuron and pancreas homeobox 1" "XP_001150658.2,motor neuron and pancreas homeobox protein 1" "PF00046,Homeobox domain" "IPR017970,Homeobox, conserved site;IPR001356,Homeobox domain;IPR020479,Homeobox domain, metazoa;IPR009057,Homeobox-like domain superfamily" "KOG0489,Transcription factor zerknullt and related HOX domain proteins;ENOG410ZTBY,-" "GO:0003677,molecular_function,DNA binding;GO:0005730,cellular_component,nucleolus;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0021520,biological_process,spinal cord motor neuron cell fate specification;GO:0031018,biological_process,endocrine pancreas development;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0048812,biological_process,neuron projection morphogenesis" "K08025,ko04950,Maturity onset diabetes of the young" NUDT18 9.531881114 10.61025316 12.59747562 7.846738108 8.677244631 5.807544232 0.693673985 4.041943648 5.732564698 0.049539466 0.742896758 "H2QVU3,Nudix" - "PF00293,NUDIX domain" "IPR015797,NUDIX hydrolase-like domain superfamily;IPR020476,NUDIX hydrolase;IPR000086,NUDIX hydrolase domain;IPR020084,NUDIX hydrolase, conserved site" "ENOG41102IB,-;ENOG410IN6N,-" "GO:0044715,molecular_function,8-oxo-dGDP phosphatase activity;GO:0016787,molecular_function,hydrolase activity;GO:0044717,molecular_function,8-hydroxy-dADP phosphatase activity;GO:0046712,biological_process,GDP catabolic process;GO:0044716,molecular_function,8-oxo-GDP phosphatase activity;GO:0046057,biological_process,dADP catabolic process;GO:0000287,molecular_function,magnesium ion binding;GO:0046067,biological_process,dGDP catabolic process" - PDLIM2 0.384426169 0.523452457 0.310209507 0.316069685 0.252897222 0.250624714 0.657544063 2.088880431 6.979267698 0.034138965 0.742896758 "G3SCD2,Uncharacterized protein" - "PF15936,omain of unknown function (DUF4749);PF00595,PDZ domain (Also known as DHR or GLGF);PF00412,LIM domain" "IPR001781,Zinc finger, LIM-type;IPR031847,Domain of unknown function DUF4749;IPR036034,PDZ superfamily;IPR001478,PDZ domain" - "GO:0046872,molecular_function,metal ion binding" - AC037459.4 6.449932188 8.995913681 6.538859464 5.189425254 4.802276064 3.48069147 0.814415248 2.843002997 10.18830414 0.015784589 0.742896758 "H7C1D1,Uncharacterized protein" - "PF15552,omain of unknown function (DUF4657);PF15936,omain of unknown function (DUF4749)" "IPR031847,Domain of unknown function DUF4749;IPR027958,Domain of unknown function DUF4657" "KOG1703,Adaptor protein Enigma and related PDZ-LIM proteins;ENOG410XRD4,-" - - C8orf58 2.618071128 3.79285488 2.502742282 1.973383022 2.155166466 1.544071801 0.752412327 3.025022801 9.281917756 0.019282828 0.742896758 "K7C0X8,Chromosome 8 open reading frame 58" "XP_016814702.1,uncharacterized protein C8orf58 homolog isoform X1" "PF15552,omain of unknown function (DUF4657)" "IPR027958,Domain of unknown function DUF4657" - - - LOXL2 16.41516529 21.17649697 18.04264112 8.908594374 9.881204526 10.44365219 1.037034999 6.359115352 17.31358048 0.004488128 0.742896758 "G3RD94,Lysyl oxidase like 2" "XP_004046829.1,-" "PF01186,Lysyl oxidase;PF00530,Scavenger receptor cysteine-rich domain" "IPR001695,Lysyl oxidase;IPR036772,SRCR-like domain superfamily;IPR017448,SRCR-like domain;IPR019828,Lysyl oxidase, conserved site;IPR001190,SRCR domain" - "GO:0000785,cellular_component,chromatin;GO:1902455,biological_process,negative regulation of stem cell population maintenance;GO:0016020,cellular_component,membrane;GO:0030199,biological_process,collagen fibril organization;GO:0005783,cellular_component,endoplasmic reticulum;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0001666,biological_process,response to hypoxia;GO:0004720,molecular_function,protein-lysine 6-oxidase activity;GO:0002040,biological_process,sprouting angiogenesis;GO:0001837,biological_process,epithelial to mesenchymal transition;GO:0001935,biological_process,endothelial cell proliferation;GO:0046688,biological_process,response to copper ion;GO:0005634,cellular_component,nucleus;GO:0070828,biological_process,heterochromatin organization;GO:0005615,cellular_component,extracellular space;GO:0005044,molecular_function,scavenger receptor activity;GO:0043542,biological_process,endothelial cell migration;GO:0006898,biological_process,receptor-mediated endocytosis;GO:0010718,biological_process,positive regulation of epithelial to mesenchymal transition;GO:0032332,biological_process,positive regulation of chondrocyte differentiation;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0018057,biological_process,peptidyl-lysine oxidation;GO:0005507,molecular_function,copper ion binding;GO:0005654,cellular_component,nucleoplasm;GO:0070492,molecular_function,oligosaccharide binding;GO:0055114,biological_process,oxidation-reduction process;GO:0016641,molecular_function,oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0006464,biological_process,cellular protein modification process" - TEX15 0.06405067 0.041112049 0.01689707 0.174265486 0.156286789 0.161276965 -1.9526675 0.270934282 20.12836747 0.003176493 0.742896758 "A0A1W2PS94,Testis-expressed protein 15" "XP_011542890.1,testis-expressed sequence 15 protein isoform X1" - "IPR032765,Testis expressed sequence 15 domain;IPR022188,Protein of unknown function DUF3715;IPR026616,Testis-expressed sequence 15 protein" - "GO:0007129,biological_process,synapsis;GO:0007140,biological_process,male meiotic nuclear division;GO:0010569,biological_process,regulation of double-strand break repair via homologous recombination" - MAK16 8.911940771 7.713036181 6.501578883 11.78664006 11.87190822 16.74187677 -0.719617367 5.671304054 7.799124649 0.027534225 0.742896758 "H2PQ12,Protein MAK16 homolog" "XP_002819029.1,protein MAK16 homolog" "PF01778,Ribosomal L28e protein family;PF04874,Mak16 protein C-terminal region" "IPR029004,Ribosomal L28e/Mak16;IPR006958,Mak16 protein" "KOG3064,RNA-binding nuclear protein (MAK16) containing a distinct C4 Zn-finger;COG5129,Nuclear protein with HMG-like acidic region" "GO:0043231,cellular_component,intracellular membrane-bounded organelle;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus" - POMK 1.144214712 0.936669872 0.314976875 1.863092138 2.002913665 2.3543708 -1.339632136 1.420026111 10.66080435 0.014861249 0.742896758 "H2QW43,Protein kinase-like protein SgK196" "XP_519740.2,protein O-mannose kinase;XP_016814936.1,-" "PF07714,Protein tyrosine kinase" "IPR001245,Serine-threonine/tyrosine-protein kinase, catalytic domain;IPR011009,Protein kinase-like domain superfamily;IPR000719,Protein kinase domain" "ENOG410IFAD,-;ENOG4111I05,-" "GO:0004672,molecular_function,protein kinase activity;GO:0016301,molecular_function,kinase activity;GO:0006468,biological_process,protein phosphorylation;GO:0019233,biological_process,sensory perception of pain;GO:0019200,molecular_function,carbohydrate kinase activity;GO:0006493,biological_process,protein O-linked glycosylation;GO:0005524,molecular_function,ATP binding;GO:0016021,cellular_component,integral component of membrane;GO:0007611,biological_process,learning or memory;GO:0016773,molecular_function,phosphotransferase activity, alcohol group as acceptor;GO:0016020,cellular_component,membrane;GO:0007420,biological_process,brain development;GO:0005789,cellular_component,endoplasmic reticulum membrane;GO:0046835,biological_process,carbohydrate phosphorylation;GO:0016310,biological_process,phosphorylation;GO:0050905,biological_process,neuromuscular process;GO:0001764,biological_process,neuron migration" - CEBPD 16.53834409 16.03960446 13.6741433 8.494650549 10.22589781 5.75402547 1.028201078 4.696153318 16.39992875 0.005148492 0.742896758 "H2RH65,CCAAT/enhancer binding protein" "XP_003951307.1,CCAAT/enhancer-binding protein delta" "PF07716,Basic region leucine zipper" "IPR016468,CCAAT/enhancer-binding protein, chordates;IPR004827,Basic-leucine zipper domain" "KOG3119,Basic region leucine zipper transcription factor;ENOG410YJ8G,-" "GO:0045669,biological_process,positive regulation of osteoblast differentiation;GO:0003677,molecular_function,DNA binding;GO:0006366,biological_process,transcription by RNA polymerase II;GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0042803,molecular_function,protein homodimerization activity;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0045892,biological_process,negative regulation of transcription, DNA-templated;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0001077,molecular_function,transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0044212,molecular_function,transcription regulatory region DNA binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0002244,biological_process,hematopoietic progenitor cell differentiation;GO:0048839,biological_process,inner ear development;GO:0005654,cellular_component,nucleoplasm;GO:0000978,molecular_function,RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0005634,cellular_component,nucleus;GO:0045444,biological_process,fat cell differentiation" - LRRCC1 4.53984216 4.323139567 2.864623475 6.727258958 6.213487075 8.026893726 -0.764491969 4.770261697 10.85602852 0.013721051 0.742896758 "H2QWD0,Leucine rich repeat and coiled-coil centrosomal protein 1" "XP_001163929.2,leucine-rich repeat and coiled-coil domain-containing protein 1" - "IPR001611,Leucine-rich repeat;IPR032675,Leucine-rich repeat domain superfamily" "KOG0531,Protein phosphatase 1, regulatory subunit, and related proteins;COG4886,Leucine-rich repeat (LRR) protein" "GO:0005813,cellular_component,centrosome" - OTUD6B 9.115905988 7.72194657 4.911897526 12.37800781 11.37943966 15.39693505 -0.783051421 5.315778968 9.100870691 0.020114397 0.742896758 "A0A087X0W9,OTU domain containing 6B, isoform CRA_b" "NP_057107.3,OTU domain-containing protein 6B isoform 1" "PF02338,OTU-like cysteine protease" "IPR003323,OTU domain" "KOG2606,OTU (ovarian tumor)-like cysteine protease;COG5539,Predicted cysteine protease (OTU family)" - - TBC1D31 4.508401991 3.972083075 1.756493243 6.299930874 6.482686996 5.06356049 -0.747042731 5.298528998 6.086395364 0.044871037 0.742896758 "H2QWN5,WD repeat domain 67" "XP_001146960.1,TBC1 domain family member 31 isoform X1" "PF00566,Rab-GTPase-TBC domain" "IPR035969,Rab-GTPase-TBC domain superfamily;IPR000195,Rab-GTPase-TBC domain;IPR017986,WD40-repeat-containing domain;IPR036322,WD40-repeat-containing domain superfamily;IPR015943,WD40/YVTN repeat-like-containing domain superfamily;IPR019775,WD40 repeat, conserved site;IPR001680,WD40 repeat" "ENOG410Y4WQ,-;KOG0295,WD40 repeat-containing protein;KOG1093,Predicted protein kinase (contains TBC and RHOD domains)" "GO:0005813,cellular_component,centrosome" - ATAD2 11.0031875 10.63693823 5.672214835 18.06026851 13.7402577 34.57294486 -1.236388282 6.778494399 8.40183827 0.024459728 0.742896758 "A0A024R9G7,ATPase family, AAA domain containing 2, isoform CRA_c" "NP_054828.2,ATPase family AAA domain-containing protein 2" "PF00439,Bromodomain;PF00004,ATPase family associated with various cellular activities (AAA)" "IPR003960,ATPase, AAA-type, conserved site;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR036427,Bromodomain-like superfamily;IPR001487,Bromodomain;IPR003593,AAA+ ATPase domain;IPR003959,ATPase, AAA-type, core;IPR031252,ATPase family AAA domain-containing protein 2" "KOG0732,AAA+-type ATPase containing the bromodomain;COG0464,ATPases of the AAA+ class" "GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0016887,molecular_function,ATPase activity;GO:0005524,molecular_function,ATP binding;GO:0006325,biological_process,chromatin organization;GO:0005654,cellular_component,nucleoplasm" - CCDC107 10.59221215 10.31312358 15.75281067 7.026702591 7.417898314 6.508235435 0.960037606 3.859114066 8.761317202 0.022474477 0.742896758 "H2QX84,Coiled-coil domain containing 107" "XP_009454856.1,coiled-coil domain-containing protein 107 isoform X1" - - "ENOG410IW9E,-;ENOG41118NC,-" - - ARHGEF39 3.633198383 4.059719867 3.837657369 2.30057678 2.490318474 2.229253032 0.831517254 4.351726321 14.12962396 0.007434944 0.742896758 "H2QX85,Uncharacterized protein" "XP_016816310.1,-" "PF00621,RhoGEF domain" "IPR011993,PH-like domain superfamily;IPR000219,Dbl homology (DH) domain;IPR001849,Pleckstrin homology domain;IPR035899,Dbl homology (DH) domain superfamily" "ENOG410IE9S,-;ENOG4110AJV,-" "GO:0005089,molecular_function,Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process,regulation of Rho protein signal transduction;GO:0005886,cellular_component,plasma membrane;GO:0065009,biological_process,regulation of molecular function;GO:0030335,biological_process,positive regulation of cell migration" - SHB 40.90943883 48.8325963 46.94853128 28.81510526 29.78052527 24.05480323 0.84855776 6.691636664 11.45601486 0.012156772 0.742896758 "K7CHY5,Src homology 2 domain containing adaptor protein B" "XP_016816394.1,-" "PF00017,SH2 domain" "IPR035040,SH2 domain-containing adapter protein B;IPR035045,SHB, SH2 domain;IPR036860,SH2 domain superfamily;IPR000980,SH2 domain" "ENOG410IGWI,-;ENOG410XQJ2,-" "GO:0006469,biological_process,negative regulation of protein kinase activity;GO:0036464,cellular_component,cytoplasmic ribonucleoprotein granule;GO:0030097,biological_process,hemopoiesis;GO:0050852,biological_process,T cell receptor signaling pathway;GO:0001784,molecular_function,phosphotyrosine residue binding;GO:0071425,biological_process,hematopoietic stem cell proliferation;GO:0042100,biological_process,B cell proliferation;GO:0045624,biological_process,positive regulation of T-helper cell differentiation;GO:0005070,molecular_function,SH3/SH2 adaptor activity;GO:1900194,biological_process,negative regulation of oocyte maturation;GO:0001568,biological_process,blood vessel development;GO:0009967,biological_process,positive regulation of signal transduction;GO:0005829,cellular_component,cytosol;GO:0048514,biological_process,blood vessel morphogenesis;GO:0045931,biological_process,positive regulation of mitotic cell cycle;GO:0007165,biological_process,signal transduction;GO:0005654,cellular_component,nucleoplasm" - IARS 8.970634472 9.640947467 4.480086065 13.1292316 12.61068298 15.55834203 -0.784441458 6.285546147 7.592395106 0.02921639 0.742896758 "Q59G75,Isoleucyl-tRNA synthetase, cytoplasmic variant" - "PF08264,Anticodon-binding domain of tRNA;PF00133,tRNA synthetases class I (I, L, M and V)" "IPR002300,Aminoacyl-tRNA synthetase, class Ia;IPR009008,Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain;IPR013155,Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding;IPR023586,Isoleucine-tRNA ligase, type 2;IPR009080,Aminoacyl-tRNA synthetase, class Ia, anticodon-binding;IPR002301,Isoleucine-tRNA ligase;IPR033709,Isoleucyl tRNA synthetase type 2, anticodon-binding domain;IPR014729,Rossmann-like alpha/beta/alpha sandwich fold;IPR001412,Aminoacyl-tRNA synthetase, class I, conserved site" "COG0060,Isoleucyl-tRNA synthetase;KOG0434,Isoleucyl-tRNA synthetase" "GO:0006428,biological_process,isoleucyl-tRNA aminoacylation;GO:0004822,molecular_function,isoleucine-tRNA ligase activity;GO:0002161,molecular_function,aminoacyl-tRNA editing activity;GO:0005737,cellular_component,cytoplasm;GO:0006418,biological_process,tRNA aminoacylation for protein translation;GO:0004812,molecular_function,aminoacyl-tRNA ligase activity;GO:0005524,molecular_function,ATP binding;GO:0016874,molecular_function,ligase activity;GO:0000049,molecular_function,tRNA binding;GO:0000166,molecular_function,nucleotide binding;GO:0006412,biological_process,translation;GO:0106074,biological_process,aminoacyl-tRNA metabolism involved in translational fidelity" - NINJ1 6.911655046 6.691197355 8.605090723 4.95517827 5.15193178 4.184999422 0.774819221 4.045005513 7.985252276 0.026551617 0.742896758 "G3RN89,Ninjurin 1" "XP_004048327.1,ninjurin-1" "PF04923,Ninjurin" "IPR015639,Ninjurin1;IPR007007,Ninjurin" - "GO:0001954,biological_process,positive regulation of cell-matrix adhesion;GO:0007155,biological_process,cell adhesion;GO:0042246,biological_process,tissue regeneration;GO:0016020,cellular_component,membrane;GO:1990384,biological_process,hyaloid vascular plexus regression;GO:0016021,cellular_component,integral component of membrane" - BARX1 1.169193929 1.618986459 1.746685917 0.370039425 0.609044099 0.624903815 1.620217532 0.949636324 17.60193477 0.004538012 0.742896758 "K7ATN6,BARX homeobox 1" - "PF00046,Homeobox domain" - - - - NR4A3 0.299477648 0.336308985 0.12484671 0.67693069 0.72171873 0.409170955 -1.183270151 1.416134977 10.13089446 0.016591831 0.742896758 "H2QXK7,Uncharacterized protein" "XP_003951532.1,nuclear receptor subfamily 4 group A member 3" "PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor" "IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR003070,Orphan nuclear receptor;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003072,Orphan nuclear receptor, NOR1 type;IPR013088,Zinc finger, NHR/GATA-type" "KOG4217,Nuclear receptors of the nerve growth factor-induced protein B type;ENOG410YWNC,-" "GO:0004879,molecular_function,nuclear receptor activity;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway" - SMC2 11.58561238 11.4658461 6.855422023 18.15619179 13.51826436 32.42380717 -1.044971535 6.648373428 7.035394738 0.034502399 0.742896758 "A0A024R158,Structural maintenance of chromosomes protein" "XP_016869695.1,-;XP_016869696.1,-;XP_011516451.1,-;NP_001252531.1,-;XP_011516450.1,-;NP_006435.2,structural maintenance of chromosomes protein 2;NP_001036016.1,-;XP_016869697.1,-;NP_001036015.1,-;XP_006716996.1,-" "PF02463,RecF/RecN/SMC N terminal domain;PF06470,SMC proteins Flexible Hinge Domain" "IPR010935,SMCs flexible hinge;IPR027417,P-loop containing nucleoside triphosphate hydrolase;IPR027120,Smc2, ATP-binding cassette domain;IPR036277,SMCs flexible hinge superfamily;IPR003395,RecF/RecN/SMC, N-terminal;IPR024704,Structural maintenance of chromosomes protein" "COG1196,Chromosome segregation ATPases;KOG0933,Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin, subunit E)" "GO:0045132,biological_process,meiotic chromosome segregation;GO:0005730,cellular_component,nucleolus;GO:0005694,cellular_component,chromosome;GO:0000796,cellular_component,condensin complex;GO:0051383,biological_process,kinetochore organization;GO:0005634,cellular_component,nucleus;GO:0051276,biological_process,chromosome organization;GO:0010032,biological_process,meiotic chromosome condensation;GO:0000793,cellular_component,condensed chromosome;GO:0005524,molecular_function,ATP binding" "K06674,ko04111,Cell cycle - yeast" AMBP 2.344740739 2.964578592 2.703564375 1.523011135 1.81406531 1.043732899 0.996830488 2.113620119 11.73273211 0.011625487 0.742896758 "Q5NVR3,Uncharacterized protein DKFZp470D2211" "NP_001127069.1,protein AMBP precursor" "PF00061,Lipocalin / cytosolic fatty-acid binding protein family;PF00014,Kunitz/Bovine pancreatic trypsin inhibitor domain" "IPR020901,Proteinase inhibitor I2, Kunitz, conserved site;IPR012674,Calycin;IPR002968,Alpha-1-microglobulin;IPR036880,Pancreatic trypsin inhibitor Kunitz domain superfamily;IPR000566,Lipocalin/cytosolic fatty-acid binding domain;IPR029856,Protein AMBP;IPR002223,Pancreatic trypsin inhibitor Kunitz domain;IPR022272,Lipocalin family conserved site" "ENOG410XQNP,-;KOG4295,Serine proteinase inhibitor (KU family)" "GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0004867,molecular_function,serine-type endopeptidase inhibitor activity;GO:0019862,molecular_function,IgA binding;GO:0005886,cellular_component,plasma membrane;GO:0020037,molecular_function,heme binding;GO:0042803,molecular_function,protein homodimerization activity" - RP11-101E3.5 7.966762737 8.456610632 8.73262277 13.12589822 12.50745241 21.40330993 -0.797860479 2.200662937 5.878203562 0.047699091 0.742896758 "H7C4K7,Uncharacterized protein" - "PF10487,Nucleoporin subcomplex protein binding to Pom34" "IPR018864,Nucleoporin Nup188" "ENOG410Z045,-;KOG4833,Uncharacterized conserved protein" "GO:0017056,molecular_function,structural constituent of nuclear pore;GO:0006913,biological_process,nucleocytoplasmic transport;GO:0005622,cellular_component,intracellular" - IER5L 15.2931665 18.67223371 20.10868161 12.01737807 12.34414231 13.37503691 0.646092621 5.403460369 5.738306135 0.048919249 0.742896758 "A0A0D9SEB6,Immediate early response 5 like" "XP_008004169.1,immediate early response gene 5-like protein" "PF05760,Immediate early response protein (IER)" "IPR008653,Immediate early response" - - - LINC00094 1.495541465 1.436100094 1.787739434 1.042178937 1.083354719 1.14181233 0.65941482 3.033474094 5.996387619 0.045241372 0.742896758 "Q6XYD6,BRD3 opposite strand" - - - - - - AGPAT2 8.543192242 8.609939612 13.01564274 7.031750035 7.033084797 4.701361737 0.844968028 3.920079133 5.914192411 0.04719633 0.742896758 "A0A024R8I7,1-acyl-sn-glycerol-3-phosphate acyltransferase" "NP_006403.2,1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a precursor" "PF01553,Acyltransferase" "IPR004552,1-acyl-sn-glycerol-3-phosphate acyltransferase;IPR002123,Phospholipid/glycerol acyltransferase" "KOG2848,1-acyl-sn-glycerol-3-phosphate acyltransferase;COG0204,1-acyl-sn-glycerol-3-phosphate acyltransferase" "GO:0006629,biological_process,lipid metabolic process;GO:0008544,biological_process,epidermis development;GO:0003841,molecular_function,1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0005783,cellular_component,endoplasmic reticulum;GO:0008654,biological_process,phospholipid biosynthetic process;GO:0042493,biological_process,response to drug;GO:0008152,biological_process,metabolic process;GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane" "K13509,ko04072,Phospholipase D signaling pathway;K13509,ko00564,Glycerophospholipid metabolism;K13509,ko00561,Glycerolipid metabolism;K13509,ko04975,Fat digestion and absorption" TMEM141 23.52242261 25.9974847 30.69411089 15.28631395 15.4937269 13.20791267 1.003385928 4.938292635 13.87185953 0.007869767 0.742896758 "G3RFI1,Uncharacterized protein" - - - - - - RP11-216L13.17 48.84869537 53.15238658 55.36743511 30.53974046 30.18579995 24.14231694 1.017162053 4.920814228 17.5328418 0.00434623 0.742896758 "V9GYN2,Uncharacterized protein" - - - - - - RP11-229P13.27 4.721352989 5.054012579 4.483908167 2.552327088 3.29609552 2.317159396 0.915687566 1.770821892 13.67001699 0.008050553 0.742896758 "A0A096LNT2,Uncharacterized protein" - - - - - - NPDC1 7.582474116 7.049235351 6.093201955 4.258950119 5.171709978 4.181394125 0.708093547 3.981960879 11.72172172 0.011538101 0.742896758 "Q5SPY9,Neural proliferation differentiation and control protein 1" - "PF06809,Neural proliferation differentiation control-1 protein (NPDC1)" "IPR009635,Neural proliferation differentiation control-1" "ENOG4111QDP,-;KOG3884,Neural proliferation, differentiation and control protein" "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - TOR4A 3.179755103 3.429330941 4.620325269 2.702123933 2.602274063 1.895811927 0.792172267 3.71257432 6.248692275 0.042842059 0.742896758 "H2R2W6,Chromosome 9 open reading frame 167" "XP_528518.2,torsin-4A isoform X2" "PF06309,Torsin" "IPR010448,Torsin;IPR003593,AAA+ ATPase domain;IPR030551,Torsin-4A;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "KOG2170,ATPase of the AAA+ superfamily;ENOG410XR06,-" "GO:0005524,molecular_function,ATP binding" - AC007325.4 9.410918907 8.696435369 15.59667852 7.022581744 6.903019504 5.92247158 0.930194227 3.495222401 6.284606433 0.04240661 0.742896758 "H2QL78,Uncharacterized protein" "XP_001164365.1,protein DGCR6;XP_016795177.1,-" "PF07324,iGeorge syndrome critical region 6 (DGCR6) protein" "IPR010849,Gonadal family" "KOG4810,Uncharacterized conserved protein;ENOG4111RN8,-" - - PLCXD1 3.95547512 4.728107259 3.07972443 2.6842733 2.994834004 2.346398377 0.642263306 4.354412302 9.234420752 0.019492833 0.742896758 "K7ARN9,Phosphatidylinositol-specific phospholipase C, X domain containing 1" - "PF00388,Phosphatidylinositol-specific phospholipase C, X domain" "IPR000909,Phosphatidylinositol-specific phospholipase C, X domain;IPR017946,PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily" - "GO:0006629,biological_process,lipid metabolic process;GO:0008081,molecular_function,phosphoric diester hydrolase activity" - CD99 25.06473587 28.02655698 34.85039931 19.73189853 19.6260986 17.92145744 0.759296149 6.347221364 6.789549352 0.036276462 0.742896758 "H7C2F2,CD99 antigen" - "PF12301,CD99 antigen like protein 2" "IPR022078,CD99 antigen-like protein 2" - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - POLA1 5.766112961 5.27577186 1.955620215 8.255352537 7.286524294 13.96007999 -1.156010319 5.461125654 7.300993433 0.032174631 0.742896758 "A6NMQ1,DNA polymerase" "NP_001317289.1,DNA polymerase alpha catalytic subunit isoform 1" "PF00136,NA polymerase family B;PF12254,NA polymerase alpha subunit p180 N terminal;PF08996,NA Polymerase alpha zinc finger;PF03104,NA polymerase family B, exonuclease domain" "IPR017964,DNA-directed DNA polymerase, family B, conserved site;IPR023211,DNA polymerase, palm domain superfamily;IPR038256,DNA polymerase alpha, zinc finger domain superfamily;IPR015088,Zinc finger, DNA-directed DNA polymerase, family B, alpha;IPR024647,DNA polymerase alpha catalytic subunit, N-terminal domain;IPR006172,DNA-directed DNA polymerase, family B;IPR036397,Ribonuclease H superfamily;IPR006134,DNA-directed DNA polymerase, family B, multifunctional domain;IPR006133,DNA-directed DNA polymerase, family B, exonuclease domain;IPR012337,Ribonuclease H-like superfamily" "COG0417,DNA polymerase elongation subunit (family B);KOG0970,DNA polymerase alpha, catalytic subunit" "GO:0051539,molecular_function,4 iron, 4 sulfur cluster binding;GO:0001882,molecular_function,nucleoside binding;GO:0003677,molecular_function,DNA binding;GO:0071897,biological_process,DNA biosynthetic process;GO:0005658,cellular_component,alpha DNA polymerase:primase complex;GO:0003676,molecular_function,nucleic acid binding;GO:0006260,biological_process,DNA replication;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0016740,molecular_function,transferase activity;GO:0016779,molecular_function,nucleotidyltransferase activity;GO:0003887,molecular_function,DNA-directed DNA polymerase activity;GO:0046872,molecular_function,metal ion binding;GO:0046982,molecular_function,protein heterodimerization activity;GO:0005829,cellular_component,cytosol;GO:0000166,molecular_function,nucleotide binding;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" - TIMP1 9.665003439 10.6089031 16.08151809 7.758363019 8.742005451 6.191330406 0.842194646 3.971686369 5.726004526 0.049905413 0.742896758 "Q6FGX5,TIMP metallopeptidase inhibitor 1, isoform CRA_a" "NP_003245.1,metalloproteinase inhibitor 1 precursor" "PF00965,Tissue inhibitor of metalloproteinase" "IPR008993,Tissue inhibitor of metalloproteinases-like, OB-fold;IPR027465,Proteinase inhibitor I35b (TIMP), C-terminal;IPR030490,Tissue inhibitor of metalloproteinase, conserved site;IPR001134,Netrin domain;IPR001820,Protease inhibitor I35 (TIMP);IPR015611,Metalloproteinase inhibitor 1" "KOG4745,Metalloproteinase inhibitor TIMP and related proteins;ENOG41103NU,-" "GO:0042060,biological_process,wound healing;GO:0010951,biological_process,negative regulation of endopeptidase activity;GO:0008191,molecular_function,metalloendopeptidase inhibitor activity;GO:0031012,cellular_component,extracellular matrix;GO:0005578,,;GO:0005581,cellular_component,collagen trimer;GO:0001775,biological_process,cell activation;GO:0002020,molecular_function,protease binding;GO:0005604,cellular_component,basement membrane;GO:0034097,biological_process,response to cytokine;GO:0043066,biological_process,negative regulation of apoptotic process;GO:0007568,biological_process,aging;GO:0043434,biological_process,response to peptide hormone;GO:0010033,biological_process,response to organic substance;GO:0051216,biological_process,cartilage development;GO:0005576,cellular_component,extracellular region;GO:0005615,cellular_component,extracellular space" "K16451,ko04066,HIF-1 signaling pathway" PRICKLE3 5.160048245 5.175636338 5.460470276 3.958386526 4.066141631 3.292210478 0.60419943 3.873766346 6.747343408 0.036377215 0.742896758 "A0A024QYW5,LIM domain only 6, isoform CRA_a" "NP_006141.2,prickle planar cell polarity protein 3 isoform 1" "PF06297,PET Domain;PF00412,LIM domain" "IPR033723,PET prickle;IPR033726,LIM2 prickle;IPR033727,LIM3 prickle;IPR033725,LIM1 prickle;IPR010442,PET domain;IPR001781,Zinc finger, LIM-type" "ENOG410XP0W,-;KOG1704,FOG: LIM domain" "GO:0008270,molecular_function,zinc ion binding;GO:0005634,cellular_component,nucleus;GO:0046872,molecular_function,metal ion binding;GO:0005813,cellular_component,centrosome" - GNL3L 9.548779892 9.445338341 6.793566999 14.24609556 12.03477132 15.39707811 -0.610068603 4.8511039 7.678866808 0.028391564 0.742896758 "A0A024R9Y6,Guanine nucleotide binding protein-like 3" "NP_061940.1,guanine nucleotide-binding protein-like 3-like protein;NP_001171748.1,-" "PF01926,50S ribosome-binding GTPase" "IPR030378,Circularly permuted (CP)-type guanine nucleotide-binding (G) domain;IPR023179,GTP-binding protein, orthogonal bundle domain superfamily;IPR006073,GTP binding domain;IPR027417,P-loop containing nucleoside triphosphate hydrolase" "COG1161,Predicted GTPases;KOG2484,GTPase" "GO:0005525,molecular_function,GTP binding;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0005730,cellular_component,nucleolus" "K14538,ko03008,Ribosome biogenesis in eukaryotes" AMER1 0.710591989 0.797784007 0.437649233 1.108052384 1.055844882 1.113924693 -0.680657961 2.864305256 8.668734496 0.022239449 0.742896758 "G3RNF3,APC membrane recruitment protein 1" - "PF09422,WTX protein" - - - - PGK1 69.13238813 88.09305174 47.49345225 50.97980939 47.8782924 38.64941839 0.653530509 8.262827591 6.476540303 0.039240511 0.742896758 "K7CCI1,Phosphoglycerate kinase" "NP_001129210.1,-" "PF00162,Phosphoglycerate kinase" "IPR001576,Phosphoglycerate kinase;IPR015824,Phosphoglycerate kinase, N-terminal;IPR015911,Phosphoglycerate kinase, conserved site;IPR036043,Phosphoglycerate kinase superfamily" "KOG1367,3-phosphoglycerate kinase;COG0126,3-phosphoglycerate kinase" "GO:0016301,molecular_function,kinase activity;GO:0006096,biological_process,glycolytic process;GO:0004618,molecular_function,phosphoglycerate kinase activity;GO:0016310,biological_process,phosphorylation;GO:0016740,molecular_function,transferase activity;GO:0005524,molecular_function,ATP binding" "K00927,ko00010,Glycolysis / Gluconeogenesis;K00927,ko01200,Carbon metabolism;K00927,ko00710,Carbon fixation in photosynthetic organisms;K00927,ko01230,Biosynthesis of amino acids" RNF113A 47.72416649 49.64836725 54.2562994 36.4059321 39.06904057 30.30018599 0.648262531 5.881463183 6.638081958 0.037498398 0.742896758 "G3QIS1,Ring finger protein 113A" "XP_004064840.1,-" "PF00642,Zinc finger C-x8-C-x5-C-x3-H type (and similar);PF13920,Zinc finger, C3HC4 type (RING finger)" "IPR001841,Zinc finger, RING-type;IPR036855,Zinc finger, CCCH-type superfamily;IPR000571,Zinc finger, CCCH-type;IPR017907,Zinc finger, RING-type, conserved site;IPR013083,Zinc finger, RING/FYVE/PHD-type" - "GO:0046872,molecular_function,metal ion binding" - PNMA6A 1.426665061 1.343716764 3.456986467 1.001264337 0.876729799 1.09772255 1.253596866 1.864405652 5.754602623 0.049480697 0.742896758 "H2PX43,Paraneoplastic Ma antigen family member 6A" "XP_002832319.1,paraneoplastic antigen-like protein 6A" "PF14893,PNMA" "IPR026523,Paraneoplastic antigen Ma" "ENOG41117XE,-;ENOG410J9MD,-" - - ZFY 0.595543681 0.520524505 0.236220784 0.984225624 0.623517255 0.889763925 -0.833932329 1.816524881 5.868768445 0.047832069 0.742896758 "A0A0D9S0E4,Zinc finger protein, Y-linked" "XP_008017166.1,zinc finger Y-chromosomal protein isoform X1;XP_008017167.1,-" "PF04704,Zfx / Zfy transcription activation region;PF00096,Zinc finger, C2H2 type;PF13909,C2H2-type zinc-finger domain" "IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily;IPR006794,Transcriptional activator, Zfx / Zfy domain" - "GO:0003677,molecular_function,DNA binding;GO:0005730,cellular_component,nucleolus;GO:0003676,molecular_function,nucleic acid binding;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0005634,cellular_component,nucleus;GO:0005654,cellular_component,nucleoplasm" - RP11-73M7.6 0.579397886 0.504877972 0.433537384 0.337196452 0.269899518 0.235213695 0.948108958 -0.108572951 8.5269002 0.02300621 0.742896758 - - - - - - - RP11-435D7.3 14.85557026 13.97929513 13.29951873 27.56007325 16.22191723 68.91197747 -1.3417127 3.802946565 5.900132655 0.047391905 0.742896758 "A0A1A6HT35,Uncharacterized protein" - - "IPR024146,Claspin" - - - LINC00853 1.695210957 1.934401706 1.527967436 0.859141871 1.249536968 0.377134054 1.17443056 -0.155327861 6.444275017 0.04028233 0.742896758 - - - - - - - RP4-784A16.2 1.175869477 1.353057701 0.766385401 2.258287067 1.814334061 2.048002989 -0.813576729 0.126372098 6.552229686 0.038411332 0.742896758 "M3W4Z5,LDL receptor related protein 8" - "PF14670,Coagulation Factor Xa inhibitory site;PF00057,Low-density lipoprotein receptor domain class A;PF00058,Low-density lipoprotein receptor repeat class B" "IPR023415,Low-density lipoprotein (LDL) receptor class A, conserved site;IPR018097,EGF-like calcium-binding, conserved site;IPR000033,LDLR class B repeat;IPR002172,Low-density lipoprotein (LDL) receptor class A repeat;IPR011042,Six-bladed beta-propeller, TolB-like;IPR001881,EGF-like calcium-binding domain;IPR000152,EGF-type aspartate/asparagine hydroxylation site;IPR000742,EGF-like domain;IPR013032,EGF-like, conserved site;IPR036055,LDL receptor-like superfamily" "ENOG410YQ6J,-;ENOG410KD0V,-" "GO:0006898,biological_process,receptor-mediated endocytosis;GO:0005901,cellular_component,caveola;GO:0005509,molecular_function,calcium ion binding;GO:0016020,cellular_component,membrane;GO:0030229,molecular_function,very-low-density lipoprotein particle receptor activity;GO:0043235,cellular_component,receptor complex;GO:0006897,biological_process,endocytosis;GO:0016021,cellular_component,integral component of membrane" - HIST2H2BC 0.965977968 0.629871688 0.764497753 2.164382635 2.357033824 1.289408326 -1.175422486 -0.283122593 8.74509143 0.021840437 0.742896758 "Q4THR3,Chromosome undetermined SCAF2744, whole genome shotgun sequence" - "PF00125,Core histone H2A/H2B/H3/H4" "IPR000558,Histone H2B;IPR009072,Histone-fold;IPR007125,Histone H2A/H2B/H3" - "GO:0005694,cellular_component,chromosome;GO:0000786,cellular_component,nucleosome;GO:0003677,molecular_function,DNA binding;GO:0005634,cellular_component,nucleus;GO:0046982,molecular_function,protein heterodimerization activity" "K11252,ko05322,Systemic lupus erythematosus;K11252,ko05034,Alcoholism;K11252,ko05203,Viral carcinogenesis" VIM-AS1 53.07585018 57.95325455 61.44851107 39.44700145 40.80535924 39.37465751 0.651590979 6.623082121 6.700918652 0.036848159 0.742896758 - - - - - - - RP11-124N14.3 361.3432598 418.6884693 511.7274113 271.1609689 275.5297978 270.439256 0.799744588 7.990715996 7.067393515 0.033563002 0.742896758 "A0A1S3F1H2,vimentin" "XP_012870055.1,vimentin" - "IPR027699,Vimentin;IPR018039,Intermediate filament protein, conserved site;IPR006821,Intermediate filament head, DNA-binding domain;IPR001664,Intermediate filament protein" - "GO:0005882,cellular_component,intermediate filament;GO:0005198,molecular_function,structural molecule activity" - CH17-360D5.3 4.465406627 3.704118313 1.699912275 8.105516889 6.79264237 6.255461042 -1.042655983 2.074281128 10.90795363 0.013991844 0.742896758 - - - - - - - BEND3P1 0.739844892 0.554270097 0.348826801 1.00772399 1.142689892 0.932165892 -0.834562885 1.225024978 8.534577403 0.022963832 0.742896758 "H2PJY5,BEN domain containing 3" - "PF10523,BEN domain" "IPR033583,BEN domain-containing protein 3;IPR018379,BEN domain" "ENOG410IHA7,-;ENOG410Y8FH,-" "GO:0043967,biological_process,histone H4 acetylation;GO:0003677,molecular_function,DNA binding;GO:0034773,biological_process,histone H4-K20 trimethylation;GO:0005730,cellular_component,nucleolus;GO:0000183,biological_process,chromatin silencing at rDNA;GO:0098532,biological_process,histone H3-K27 trimethylation;GO:0000122,biological_process,negative regulation of transcription by RNA polymerase II;GO:0051260,biological_process,protein homooligomerization;GO:0006306,biological_process,DNA methylation;GO:0000182,molecular_function,rDNA binding;GO:0005720,cellular_component,nuclear heterochromatin;GO:1903580,biological_process,positive regulation of ATP metabolic process;GO:0036124,biological_process,histone H3-K9 trimethylation;GO:0080182,biological_process,histone H3-K4 trimethylation;GO:0005654,cellular_component,nucleoplasm" - HSP90AA2P 3.922635942 2.682547799 1.671420152 4.614026733 4.344752504 7.832744569 -0.972029272 3.184574001 6.947769101 0.035318864 0.742896758 "G1S1H7,Heat shock protein 90 alpha family class A member 1" - "PF00183,Hsp90 protein;PF02518,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase" "IPR001404,Heat shock protein Hsp90 family;IPR037196,HSP90, C-terminal domain" "COG0326,Molecular chaperone, HSP90 family;KOG0019,Molecular chaperone (HSP90 family);KOG0020,Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family" "GO:0005737,cellular_component,cytoplasm;GO:0009408,biological_process,response to heat;GO:0006457,biological_process,protein folding;GO:0009409,biological_process,response to cold;GO:0005634,cellular_component,nucleus;GO:0046677,biological_process,response to antibiotic;GO:0051082,molecular_function,unfolded protein binding;GO:0006950,biological_process,response to stress;GO:0005524,molecular_function,ATP binding" "K04079,ko04626,Plant-pathogen interaction;K04079,ko04151,PI3K-Akt signaling pathway;K04079,ko04612,Antigen processing and presentation;K04079,ko04915,Estrogen signaling pathway;K04079,ko05215,Prostate cancer;K04079,ko04141,Protein processing in endoplasmic reticulum;K04079,ko04914,Progesterone-mediated oocyte maturation;K04079,ko04621,NOD-like receptor signaling pathway;K04079,ko05200,Pathways in cancer" SNORD26 8.40400832 7.915387551 1.970705318 15.94084988 17.08849522 34.74890318 -1.861291275 0.14536605 10.41003316 0.015649166 0.742896758 - - - - - - - RP11-91P24.6 3.377078874 4.297193436 4.566943503 2.686660093 3.12009042 1.686942967 0.847889457 1.282460957 6.078706223 0.044652177 0.742896758 "H2Q4G7,Adipogenesis associated Mth938 domain containing" "XP_016775230.1,mth938 domain-containing protein isoform X2;XP_016775231.1,-" "PF04430,Protein of unknown function (DUF498/DUF598)" "IPR007523,NDUFAF3/Mth938 domain-containing protein;IPR036748,MTH938-like superfamily;IPR034096,Mth938 domain-containing protein" "ENOG41120BN,-;ENOG410IXVS,-" "GO:0045600,biological_process,positive regulation of fat cell differentiation;GO:0045944,biological_process,positive regulation of transcription by RNA polymerase II;GO:0043066,biological_process,negative regulation of apoptotic process" - RP11-290C10.1 1.558462368 2.508755282 0.411134628 0.540414765 0.554564054 0.283673092 1.739466318 -0.433833412 7.642025886 0.029479436 0.742896758 - - - - - - - RP11-860B13.1 2.441026799 2.555664951 1.451182119 3.081349848 3.984798837 3.904996163 -0.694351293 0.993289661 5.968243206 0.045465077 0.742896758 "A0A096NGJ6,Kelch like family member 42" "XP_003906207.1,kelch-like protein 42" "PF01344,Kelch motif;PF07707,BTB And C-terminal Kelch" "IPR006652,Kelch repeat type 1;IPR011705,BTB/Kelch-associated;IPR000210,BTB/POZ domain;IPR015915,Kelch-type beta propeller;IPR011333,SKP1/BTB/POZ domain superfamily" - "GO:0043161,biological_process,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209,biological_process,protein polyubiquitination;GO:0004842,molecular_function,ubiquitin-protein transferase activity;GO:0032886,biological_process,regulation of microtubule-based process;GO:0031463,cellular_component,Cul3-RING ubiquitin ligase complex" - RP11-210N13.1 0.518765946 0.448850872 0.168436352 0.817479481 1.144101532 0.949106051 -1.295726321 -0.290276882 9.232967346 0.019545371 0.742896758 "H0YA82,La-related protein 7" - "PF08777,RNA binding motif" "IPR034910,LARP7, RNA recognition motif 2;IPR012677,Nucleotide-binding alpha-beta plait domain superfamily;IPR035979,RNA-binding domain superfamily;IPR014886,La protein, RNA-binding domain" "ENOG410IQXQ,-;COG5193,La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation" "GO:0003723,molecular_function,RNA binding;GO:0003676,molecular_function,nucleic acid binding" - RP11-161H23.9 0.806913905 1.07422908 0.561740894 0.57396243 0.560592338 0.37534821 0.777840076 1.475382094 7.229173498 0.031924698 0.742896758 "G3STD0,Peripherin" - "PF00038,Intermediate filament protein;PF04732,Intermediate filament head (DNA binding) region" "IPR006821,Intermediate filament head, DNA-binding domain;IPR018039,Intermediate filament protein, conserved site;IPR001664,Intermediate filament protein;IPR027700,Peripherin/Plasticin" "ENOG410IE39,-;ENOG410YCMG,-" "GO:0045098,cellular_component,type III intermediate filament;GO:0005882,cellular_component,intermediate filament;GO:0005198,molecular_function,structural molecule activity" - RP11-1100L3.8 4.362736559 4.566569741 5.303674147 25.21790186 29.50800268 4.260022343 -1.894600229 3.439836856 8.231045963 0.025483838 0.742896758 "F7HG84,Nuclear receptor subfamily 4 group A member 1" "XP_002798634.1,nuclear receptor subfamily 4 group A member 1" "PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor" "IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR003070,Orphan nuclear receptor;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003071,Orphan nuclear receptor, HMR type;IPR013088,Zinc finger, NHR/GATA-type" "KOG4217,Nuclear receptors of the nerve growth factor-induced protein B type;ENOG410YWNC,-" "GO:0004879,molecular_function,nuclear receptor activity;GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0030522,biological_process,intracellular receptor signaling pathway;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway" "K04465,ko04010,MAPK signaling pathway;K04465,ko04925,Aldosterone synthesis and secretion;K04465,ko04151,PI3K-Akt signaling pathway" MIR616 6.257279963 6.5909254 3.555396192 21.56944894 26.42550808 12.61614145 -1.790363426 0.324144124 21.59274506 0.002518793 0.742896758 - - - - - - - THRIL 4.21546531 4.261669789 3.065209333 6.334613146 4.941286344 8.574315359 -0.705354902 3.366082425 6.208723134 0.042857468 0.742896758 "Q6ZPA0,cDNA FLJ26177 fis, clone ADG04148" - - - - - - RP11-380N8.7 5.685182831 6.643177964 1.645793773 12.17465232 10.61892842 10.15897469 -1.200227746 1.835910838 7.975970666 0.027120803 0.742896758 - - - - - - - RP11-142E9.1 0.100709524 0.049251184 0.0743903 0.348147336 0.196588959 0.35196023 -1.893078102 -0.149899853 16.99271466 0.004853723 0.742896758 "H2R8K3,High mobility group AT-hook 2" - - "IPR000637,HMG-I/HMG-Y, DNA-binding, conserved site;IPR000116,High mobility group protein HMGA;IPR017956,AT hook, DNA-binding motif" "ENOG410IZGR,-;ENOG410YWK3,-" "GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0048741,biological_process,skeletal muscle fiber development;GO:0003677,molecular_function,DNA binding;GO:0000785,cellular_component,chromatin;GO:0005634,cellular_component,nucleus" - DIAPH3-AS1 2.482527333 2.683711695 1.378758385 4.238005799 3.081880357 8.244690282 -1.201350422 1.003712488 6.876107674 0.036005598 0.742896758 "Q5RE41,Uncharacterized protein DKFZp468P0520" "NP_001127217.1,protein diaphanous homolog 3" "PF06367,iaphanous FH3 Domain;PF06371,iaphanous GTPase-binding Domain" "IPR014768,Rho GTPase-binding/formin homology 3 (GBD/FH3) domain;IPR011989,Armadillo-like helical;IPR010473,Formin, GTPase-binding domain;IPR010472,Formin, FH3 domain;IPR016024,Armadillo-type fold;IPR027654,Formin, protein diaphanous homologue 3;IPR015425,Formin, FH2 domain" - "GO:0030036,biological_process,actin cytoskeleton organization;GO:0017048,molecular_function,Rho GTPase binding;GO:0003779,molecular_function,actin binding;GO:0016043,biological_process,cellular component organization" "K05745,ko04810,Regulation of actin cytoskeleton" CTD-2213F21.2 2.580795408 2.256512686 1.389176697 3.120748459 3.832428204 4.542588392 -0.819016945 2.395182073 8.92094179 0.020988565 0.742896758 - - - - - - - RP11-519G16.5 1.921355354 2.56830397 2.16263958 1.312004106 1.44552886 0.652824268 1.089996957 0.364138604 7.795969852 0.027723208 0.742896758 "H2PG84,Uncharacterized protein" - - - - - - RP11-77H9.5 11.41538756 11.61181548 10.11853586 7.67323917 6.615350636 6.538275606 0.774185609 1.911169617 11.87422936 0.011201421 0.742896758 - - - - - - - CTD-2515O10.5 40.35899295 51.59345621 69.02205884 33.91262535 29.46670009 31.42218962 0.914450278 4.519320817 7.416165081 0.03122947 0.742896758 "A0A287A1V5,Fructose-bisphosphate aldolase" - - "IPR029768,Fructose-bisphosphate aldolase class-I active site;IPR000741,Fructose-bisphosphate aldolase, class-I;IPR013785,Aldolase-type TIM barrel" - "GO:0004332,molecular_function,fructose-bisphosphate aldolase activity;GO:0003824,molecular_function,catalytic activity;GO:0006096,biological_process,glycolytic process;GO:0016829,molecular_function,lyase activity" - CES1P1 1.396151094 1.365552957 1.112168788 0.902543721 0.968565155 0.730828525 0.675440899 1.904659823 9.109647826 0.020058889 0.742896758 "K7C7K7,Carboxylic ester hydrolase" - "PF07859,alpha/beta hydrolase fold;PF00135,Carboxylesterase family" "IPR019819,Carboxylesterase type B, conserved site;IPR019826,Carboxylesterase type B, active site;IPR029058,Alpha/Beta hydrolase fold;IPR002018,Carboxylesterase, type B" "COG2272,Carboxylesterase type B;KOG1516,Carboxylesterase and related proteins" "GO:0016787,molecular_function,hydrolase activity" - RP11-343H19.2 8.60059331 13.01182304 7.510855113 1.898581259 1.550680147 1.68630754 2.584695824 1.699022184 82.11403947 4.79E-05 0.41796269 "G1QV94,Developmental pluripotency associated 2" "XP_003261833.1,developmental pluripotency-associated protein 2" "PF14047,ppa2/4 conserved region;PF14049,ppa2/4 conserved region in higher vertebrates" "IPR025892,Developmental pluripotency-associated protein 2/4, central domain;IPR025891,Developmental pluripotency-associated protein 2/4, C-terminal domain;IPR003034,SAP domain" "ENOG410IJEN,-;ENOG4111ADR,-" "GO:0005634,cellular_component,nucleus" - RP11-542C16.1 15.74781184 19.14488264 19.48470519 9.868370548 10.35051373 8.989569603 1.02217921 2.593662849 15.79556839 0.005655772 0.742896758 - - - - - - - AC113189.5 6.310508243 6.992290152 10.98975555 4.859096491 5.168542978 4.6267135 0.889308692 2.839098017 6.147594906 0.044099974 0.742896758 - - - - - - - LRRC75A-AS1 26.23846114 28.02627399 27.11096003 18.79697183 20.97988972 18.50847232 0.597536021 6.467781552 6.630533522 0.037577518 0.742896758 "Q7Z306,Uncharacterized protein DKFZp686I23148" - - - - - - SNORD49B 136.8245182 154.7559746 173.120988 83.8555124 103.638559 113.6263954 0.750183338 3.237877673 6.945765565 0.034910818 0.742896758 - - - - - - - RARA-AS1 2.008406706 2.206750182 2.036762479 1.569594856 1.559285411 0.911557334 0.752031064 1.654222971 6.681919712 0.037062982 0.742896758 "A8MUP8,Retinoic acid receptor alpha" "XP_005257609.1,retinoic acid receptor alpha isoform X4" "PF00105,Zinc finger, C4 type (two domains);PF00104,Ligand-binding domain of nuclear hormone receptor" "IPR000536,Nuclear hormone receptor, ligand-binding domain;IPR035500,Nuclear hormone receptor-like domain superfamily;IPR001723,Nuclear hormone receptor;IPR001628,Zinc finger, nuclear hormone receptor-type;IPR003078,Retinoic acid receptor;IPR013088,Zinc finger, NHR/GATA-type" - "GO:0003707,molecular_function,steroid hormone receptor activity;GO:0003677,molecular_function,DNA binding;GO:0003708,molecular_function,retinoic acid receptor activity;GO:0043565,molecular_function,sequence-specific DNA binding;GO:0015629,cellular_component,actin cytoskeleton;GO:0003700,molecular_function,DNA binding transcription factor activity;GO:0046872,molecular_function,metal ion binding;GO:0006355,biological_process,regulation of transcription, DNA-templated;GO:0006351,biological_process,transcription, DNA-templated;GO:0048384,biological_process,retinoic acid receptor signaling pathway;GO:0005829,cellular_component,cytosol;GO:0005634,cellular_component,nucleus;GO:0008270,molecular_function,zinc ion binding;GO:0043401,biological_process,steroid hormone mediated signaling pathway" - RP11-1072C15.4 0.599741089 0.524382279 0.421910442 0.698071472 0.897994105 1.164432587 -0.754837873 0.909728104 5.745295401 0.048605258 0.742896758 "G3R921,Meiosis specific with coiled-coil domain" "XP_004041624.1,meiosis-specific coiled-coil domain-containing protein MEIOC isoform X1" "PF15189,Meiosis-specific coiled-coil domain-containing protein MEIOC" "IPR027963,Meiosis-specific coiled-coil domain-containing protein MEIOC" - "GO:0007286,biological_process,spermatid development;GO:0007283,biological_process,spermatogenesis;GO:0007144,biological_process,female meiosis I;GO:0007130,biological_process,synaptonemal complex assembly;GO:0005737,cellular_component,cytoplasm;GO:0070192,biological_process,chromosome organization involved in meiotic cell cycle;GO:0051321,biological_process,meiotic cell cycle;GO:0005634,cellular_component,nucleus;GO:0048255,biological_process,mRNA stabilization;GO:0006302,biological_process,double-strand break repair;GO:0051310,biological_process,metaphase plate congression;GO:0051729,biological_process,germline cell cycle switching, mitotic to meiotic cell cycle;GO:0048599,biological_process,oocyte development;GO:0007141,biological_process,male meiosis I" - RP11-1055B8.4 0.715996449 1.079636297 0.550916023 0.24828001 0.454965261 0.33305658 1.252852929 -0.095238489 10.20897617 0.015714861 0.742896758 - - - - - - - RP11-839G9.1 11.48696023 12.7654551 4.301142558 19.71520455 20.44390816 16.82687858 -0.949257293 2.984364027 7.741824029 0.028747234 0.742896758 - - - - - - - CTD-3113P16.5 1.938193801 2.443367574 3.363288596 0.992626722 1.261143559 1.212559994 1.29959335 0.1372679 9.674528902 0.017882884 0.742896758 - - - - - - - CTC-510F12.6 4.328775441 4.712740296 2.746153933 2.738184065 3.11214317 2.226211044 0.627141046 1.600721835 6.162332601 0.042945042 0.742896758 - - - - - - - CTD-2192J16.15 1.737262702 2.053186395 1.909598176 1.065812637 1.413002189 0.772978635 0.932331354 0.034316684 6.682647223 0.037035699 0.742896758 "H2R6C7,Uncharacterized protein" - "PF00252,Ribosomal protein L16p/L10e" - - - - AC008440.5 24.88972782 27.31305306 46.53054222 19.43144378 20.33382804 15.00106829 1.022654784 3.498166297 6.862164364 0.036141257 0.742896758 - - - - - - - CTD-2619J13.14 1.988071425 1.87099726 2.032992755 1.565744145 1.266925799 1.379503733 0.60182891 2.555883179 5.972807941 0.04540361 0.742896758 "Q9BZ57,FKSG67" - - - - - - WASH2P 1.35742002 1.219604495 1.165900712 1.101389856 0.741387273 0.651216326 0.697422935 1.653771132 6.112500898 0.043574181 0.742896758 "A9QQ16,Actin nucleation promoting factor" - "PF11945,WAHD domain of WASH complex" "IPR028290,WASH1;IPR021854,WASH1, WAHD domain" "ENOG410IFZ4,-;ENOG410YN2V,-" "GO:0034314,biological_process,Arp2/3 complex-mediated actin nucleation;GO:0043014,molecular_function,alpha-tubulin binding;GO:0005769,cellular_component,early endosome;GO:0071203,cellular_component,WASH complex" - FAM133DP 3.513494393 2.907801282 1.568578762 4.714777416 4.286549694 6.493691716 -0.901849692 1.438638014 7.430227129 0.030774352 0.742896758 "K7DJ32,Family with sequence similarity 133, member B" "NP_001238826.1,-" - "IPR026766,Protein FAM133" - - - EIF2S2P4 3.155298968 2.598860828 1.477027614 4.708139733 3.675878884 4.974657401 -0.824658608 1.751783153 7.877757288 0.027106904 0.742896758 "A0A286XBK6,Eukaryotic translation initiation factor 2 subunit beta" "XP_003467738.1,eukaryotic translation initiation factor 2 subunit 2" - "IPR016190,Translation initiation factor IF2/IF5, zinc-binding;IPR016189,Translation initiation factor IF2/IF5, N-terminal;IPR002735,Translation initiation factor IF2/IF5" - "GO:0006413,biological_process,translational initiation;GO:0003743,molecular_function,translation initiation factor activity" - FTH1P20 3.961743581 3.583257279 3.820938686 2.345312084 2.80650469 2.191794512 0.746422507 0.831551393 6.95356099 0.034378005 0.742896758 "G3RMF9,Ferritin" "XP_004051373.1,-" "PF00210,erritin-like domain" "IPR008331,Ferritin/DPS protein domain;IPR012347,Ferritin-like;IPR009040,Ferritin-like diiron domain;IPR001519,Ferritin;IPR009078,Ferritin-like superfamily;IPR014034,Ferritin, conserved site" - "GO:0005623,cellular_component,cell;GO:0008199,molecular_function,ferric iron binding;GO:0046872,molecular_function,metal ion binding;GO:0006879,biological_process,cellular iron ion homeostasis;GO:0006826,biological_process,iron ion transport" - ENO1P4 2.62870475 2.366429698 1.048834763 3.700554437 3.191128893 3.821490631 -0.775634275 2.301785697 6.284373635 0.042172654 0.742896758 "L0R6S1,Alternative protein TMEM237" - "PF03952,nolase, N-terminal domain" "IPR020811,Enolase, N-terminal;IPR000941,Enolase;IPR029017,Enolase-like, N-terminal" - "GO:0004634,molecular_function,phosphopyruvate hydratase activity;GO:0000015,cellular_component,phosphopyruvate hydratase complex;GO:0000287,molecular_function,magnesium ion binding;GO:0006096,biological_process,glycolytic process" - RP11-103J8.1 0.803093489 0.749788621 0.539286053 1.121717349 1.536494879 1.222596281 -0.801338363 0.381684033 7.173076583 0.032404996 0.742896758 - - - - - - - RP4-621N11.2 3.650713004 3.881911868 0.989593775 5.510399596 5.250769096 10.45328336 -1.301633176 2.768198401 6.485370118 0.04007701 0.742896758 "Q8WVU8,RBL1 protein" - - - "ENOG4111A36,-;ENOG410KEIE,-" - - SNORD12C 3.672163436 3.078586342 1.107137819 18.13495562 20.48059352 16.29650564 -2.722848459 -0.078142294 40.69633074 0.000417291 0.742896758 - - - - - - - ZNFX1-AS1_3 455.0829537 456.9194207 454.7345891 328.7800288 353.5550736 305.0297273 0.585589224 5.110308045 7.21818084 0.032018079 0.742896758 - - - - - - - CTD-3184A7.4 2.622973883 2.593994048 5.012874013 1.343330046 1.528933197 0.820483791 1.651148581 1.001617016 11.86494602 0.011723155 0.742896758 - - - - - - - ZDHHC8P1 1.092598206 0.719419828 0.610382115 0.402300433 0.365920669 0.61699211 0.872505377 1.094416254 6.290996143 0.041857862 0.742896758 "G3QES5,Palmitoyltransferase" - "PF01529,HHC palmitoyltransferase" "IPR001594,Palmitoyltransferase, DHHC domain;IPR030291,Palmitoyltransferase ZDHHC8" - "GO:0016409,molecular_function,palmitoyltransferase activity;GO:0019706,molecular_function,protein-cysteine S-palmitoyltransferase activity;GO:0016740,molecular_function,transferase activity;GO:0018345,biological_process,protein palmitoylation;GO:0016020,cellular_component,membrane;GO:0016746,molecular_function,transferase activity, transferring acyl groups;GO:0016021,cellular_component,integral component of membrane" - SUCLG2-AS1 0.554354111 0.504551736 0.211239851 0.906925002 0.676325668 0.986618508 -0.968410283 0.963745205 6.940812183 0.035119099 0.742896758 "G3RNK2,Uncharacterized protein" - - - - - - RP11-646I6.6 2.251073657 2.935651977 1.715569361 4.216497123 3.204092854 5.260897609 -0.803752898 0.893871989 6.035537473 0.044569861 0.742896758 "G1RBV9,Amidophosphoribosyltransferase" - "PF00156,Phosphoribosyl transferase domain;PF13522,lutamine amidotransferase domain" "IPR035584,Amidophosphoribosyltransferase, N-terminal;IPR000836,Phosphoribosyltransferase domain;IPR017932,Glutamine amidotransferase type 2 domain;IPR005854,Amidophosphoribosyltransferase;IPR029055,Nucleophile aminohydrolases, N-terminal;IPR029057,Phosphoribosyltransferase-like" "COG0034,Glutamine phosphoribosylpyrophosphate amidotransferase;KOG0572,Glutamine phosphoribosylpyrophosphate amidotransferase" "GO:0016757,molecular_function,transferase activity, transferring glycosyl groups;GO:0009113,biological_process,purine nucleobase biosynthetic process;GO:0006189,biological_process,'de novo' IMP biosynthetic process;GO:0006164,biological_process,purine nucleotide biosynthetic process;GO:0051536,molecular_function,iron-sulfur cluster binding;GO:0016740,molecular_function,transferase activity;GO:0046872,molecular_function,metal ion binding;GO:0004044,molecular_function,amidophosphoribosyltransferase activity;GO:0009116,biological_process,nucleoside metabolic process" "K00764,ko00230,Purine metabolism;K00764,ko00250,Alanine, aspartate and glutamate metabolism" FLJ20021 4.993943059 5.231323564 8.69979088 3.367252309 3.388857702 3.241573522 1.080713926 2.002505512 8.293173324 0.025104906 0.742896758 "H2RFR4,Uncharacterized protein" - - - - - - HHIP-AS1 5.067713573 4.956649237 2.832018721 3.225027433 3.127951919 2.518036462 0.610267194 2.496981011 6.453115423 0.03950188 0.742896758 - - - - - - - AC097467.2 0.299454966 0.165547704 0.068694413 0.38896385 0.402406159 0.387606282 -1.099863293 0.625666916 5.800103543 0.04881476 0.742896758 "B5BUM4,Uncharacterized protein" - - - - - - MIR4458HG 0.505734029 0.478863617 0.567730271 0.29620443 0.354451387 0.349936849 0.75424539 0.948889847 6.258075741 0.041769336 0.742896758 - - - - - - - LINC00847 2.483858961 2.959986094 2.942400418 1.973923013 2.182794606 1.69066696 0.645276304 2.572212108 6.499330023 0.0389884 0.742896758 - - - - - - - RP11-420L9.5 3.086103099 3.448496165 3.604513529 2.208393727 2.826420192 1.945299447 0.667097724 3.006968852 6.408475938 0.040033465 0.742896758 "H2PHS7,Uncharacterized protein" - - "IPR036871,PX domain superfamily" "ENOG410IEEQ,-;ENOG411016X,-" "GO:0035091,molecular_function,phosphatidylinositol binding" - HCG4P7 3.399912198 3.325399504 4.269861522 2.605715846 2.512154853 1.417848223 0.896584886 1.564261091 6.650135385 0.038289764 0.742896758 "O95141,Uncharacterized protein" - - - - - - HCG4P5 76.21627776 76.68434082 72.48742369 54.02912677 56.35933721 34.30159036 0.759030902 5.950684921 8.418949709 0.023613049 0.742896758 "O95141,Uncharacterized protein" - - - - - - PSMB8-AS1 1.411915516 1.533112855 1.691917687 1.057071991 1.080256831 0.638866247 0.875986555 1.32238297 7.466168783 0.030180036 0.742896758 "L8E792,Alternative protein TAP1" - - - - - - RP11-632C17__A.1 7.485989596 5.009738957 6.548229695 3.783429561 4.206029063 3.777054693 0.811204081 1.333808357 7.8059015 0.027486924 0.742896758 "F7E9I6,60S ribosomal protein L29" - "PF01779,Ribosomal L29e protein family" "IPR002673,Ribosomal protein L29e" "KOG3504,60S ribosomal protein L29;ENOG4112428,-" "GO:0006412,biological_process,translation;GO:0005840,cellular_component,ribosome;GO:0003735,molecular_function,structural constituent of ribosome;GO:0030529,,;GO:0005622,cellular_component,intracellular" - SNORD101 8.634255123 7.506689986 2.024697244 11.46430985 16.77637659 19.24745679 -1.345315463 -0.269339534 6.89376472 0.035834767 0.742896758 - - - - - - - GS1-124K5.12 7.257347426 7.808124428 3.74399974 10.84060387 9.739556862 10.48964412 -0.661777294 2.255109524 6.238776516 0.042002895 0.742896758 "B4DLB4,cDNA FLJ59924" - - - - - - RP11-155G14.6 22.18077053 32.52473766 8.595787923 10.88107483 9.120747701 6.504293581 1.300808721 3.288533033 9.476918731 0.019110769 0.742896758 "G3QRR3,EF-hand calcium binding domain 3" "XP_004041182.2,EF-hand calcium-binding domain-containing protein 3" "PF13833,-hand domain pair" "IPR002048,EF-hand domain;IPR018247,EF-Hand 1, calcium-binding site;IPR011992,EF-hand domain pair" - "GO:0005509,molecular_function,calcium ion binding" - LINC01006 0.571244539 0.627845739 0.472293151 0.354386326 0.344873768 0.285851768 0.860397048 0.859687031 10.96069359 0.013430067 0.742896758 "A0A096NXX1,Uncharacterized protein" - - - - - - RP11-177H13.2 2.71979103 3.616708007 2.479811037 1.557372527 1.626458139 1.856251556 0.896689294 3.487236379 14.76454876 0.006681271 0.742896758 "Q8N8C2,cDNA FLJ39679 fis, clone SMINT2010068" - - - - "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - RN7SKP97 1.121656099 1.371342265 0.073975425 4.398094844 4.276400206 1.701375988 -1.949836079 -0.44776353 6.411804971 0.040910556 0.742896758 "A0A0P5WRE6,Uncharacterized protein" - - - - - - RP11-629O1.2 2.441026799 1.950375884 3.011202897 1.716752058 0.755014516 0.901152961 1.2769597 0.384869413 7.736136125 0.028788318 0.742896758 - - - - - - - GS1-393G12.12 4.363943259 3.754049449 7.434530196 1.817580012 2.373402114 2.501022702 1.372305233 0.82634481 9.353378525 0.019641868 0.742896758 "Q3KQR6,DGAT1 protein" - - - - - - GLIS3-AS1 0.9223291 1.088759816 0.335610579 1.87315845 2.522143936 1.296754472 -1.209321569 0.000680356 7.072592313 0.033998865 0.742896758 "Q1PHK2,GLIS family zinc finger 3 transcript variant TE2" - "PF00096,Zinc finger, C2H2 type" "IPR030405,Zinc finger protein GLIS3;IPR013087,Zinc finger C2H2-type;IPR036236,Zinc finger C2H2 superfamily" "KOG1721,FOG: Zn-finger;COG5048,FOG: Zn-finger" "GO:0006357,biological_process,regulation of transcription by RNA polymerase II;GO:0005634,cellular_component,nucleus;GO:0003676,molecular_function,nucleic acid binding" - RP11-54D18.4 0.937528817 0.733585501 0.494654949 0.960292162 1.715712372 2.070554079 -1.064997351 0.241455873 6.725089787 0.036970208 0.742896758 "G3RJ84,PC4 and SFRS1 interacting protein 1" "XP_018889177.1,-;XP_018889178.1,-" "PF11467,Lens epithelium-derived growth factor (LEDGF);PF00855,PWWP domain" "IPR021567,Lens epithelium-derived growth factor, integrase-binding domain;IPR035441,TFIIS/LEDGF domain superfamily;IPR036218,HIV integrase-binding domain superfamily;IPR035496,HDGF-related, PWWP domain;IPR000313,PWWP domain;IPR017859,Treacle-like, Treacher Collins Syndrome" - "GO:0009408,biological_process,response to heat;GO:0000395,biological_process,mRNA 5'-splice site recognition;GO:0006979,biological_process,response to oxidative stress;GO:0005654,cellular_component,nucleoplasm" - RP11-384P7.7 0.198507377 0.148853606 0.020947123 0.355822542 0.363275834 0.340448807 -1.488200018 -0.215505021 5.808008243 0.04870028 0.742896758 "A0A2C1L4S6,Uncharacterized protein" - - - - - - RP11-247A12.2 1.877352286 1.786311153 2.637799404 1.20183418 1.493749582 1.030105825 0.909216447 1.992540225 7.341071097 0.031841515 0.742896758 "M3WVJ6,Immediate early response 5 like" - "PF05760,Immediate early response protein (IER)" - - - - RP11-334J6.7 2.590005431 2.869886255 2.914653552 1.78475236 2.194062846 1.996423306 0.606235174 2.728523612 6.006340995 0.044955392 0.742896758 "O95209,Uncharacterized protein LQFBS-1" - - - - - - NALT1 2.531844827 2.287482085 1.245275649 1.153806919 1.439747606 1.062296633 0.799420254 0.847840088 6.906888528 0.03481763 0.742896758 - - - - - - - SNHG7 2.976486772 2.811409449 3.515067022 1.850441003 2.431849531 1.705542303 0.772120095 3.50322202 7.569201135 0.02957192 0.742896758 "H2QY67,Uncharacterized protein" "XP_016817660.1,protein FAM69B isoform X2" "PF12260,Protein-kinase domain of FAM69;PF14875,N-term cysteine-rich ER, FAM69" "IPR029244,FAM69, N-terminal;IPR022049,FAM69, protein-kinase domain" "ENOG410IVAA,-;ENOG410YQ9F,-" "GO:0016021,cellular_component,integral component of membrane;GO:0016020,cellular_component,membrane" - RP11-216L13.19 13.80743133 14.45290354 19.33200545 10.26640375 10.31485486 9.049247992 0.828890414 5.840592053 7.733316271 0.028566172 0.742896758 "Q8WP30,Uncharacterized protein" - - - - - -