,Univariable OR[95%CI],Multivariable OR[95%CI]
Rare disease groups,,
Neurology and neurodevelopmental disorders,4.07[1.61-10.38],4.22[1.60-11.08]
Respiratory disorders,5.28[0.09-104.83],5.98[0.25-144.81]
Cardiovascular disorders,1.16[0.12-5.36],0.94[0.17-5.11]
Renal and urinary tract disorders,0.85[0.09-3.80],0.48[0.10-2.46]
Tumour syndromes,2.10[0.04-19.92],0.78[0.08-7.89]
Ophthalmological disorders,0.85[0.02-6.26],0.34[0.04-3.03]
Haematological and immunological disorders,-,-
Metabolic disorders,-,-
Hearing and ear disorders,-,-
Dermatological disorders,-,-
Rheumatological disorders,-,-
Ultra-rare disorders,-,-
Genomic medicine service indications,-,-
Dysmorphic and congenital abnormality syndromes,-,-
Endocrine disorders,-,-
Skeletal disorders,-,-
Ciliopathies,-,-
Rare disease specific diseases,,
Early onset dystonia,5.28[0.09-104.83],26.64[2.01-352.67]
Early onset and familial Parkinson's Disease,10.92[0.76-157.41],11.99[1.25-114.71]
Intellectual disability,2.70[0.26-14.71],8.10[1.11-59.00]
Hereditary ataxia,7.88[1.52-36.33],4.34[0.88-21.35]
Early onset dementia,5.28[0.09-104.83],5.98[0.25-144.81]
Hereditary haemorrhagic telangiectasia,10.51[0.13-837.21],9.08[0.22-374.97]
Epilepsy pluss other features,1.31[0.14-6.17],1.15[0.21-6.30]
Unexplained kidney failure in young people,2.10[0.04-19.92],1.14[0.10-13.26]
Familial breast andd or ovarian cancer,3.52[0.06-45.75],1.05[0.09-12.01]
Familial Thoracic Aortic Aneurysm Disease,2.63[0.05-28.04],1.02[0.09-11.30]
Hereditary spastic paraplegia,3.52[0.06-45.75],0.85[0.08-9.04]
Cystic kidney disease,-,-
Dilated Cardiomyopathy,-,-
Proteinuric renal disease,inf[0.26-Inf],-
Primary immunodeficiency,-,-
Limb girdle muscular dystrophy,-,-
Brugada syndrome,-,-
Familial haematuria,-,-
Mitochondrial disorders,-,-
Familial Hypercholesterolaemia,-,-
Congenital hearing impairment,-,-
Familial hidradenitis suppurativa,-,-
Primary lymphoedema,-,-
Classical Ehlers-Danlos Syndrome,-,-
Familial pulmonary fibrosis,-,-
Cerebellar hypoplasia,-,-
Ultra-rare undescribed monogenic disorders,-,-
Other rare neuromuscular disorders,-,-
VACTERL-like phenotypes,-,-
Long QT syndrome,-,-
Congenital Anomaly of the Kidneys and Urinary Tract (CAKUT),-,-
Rod-cone dystrophy,-,-
Skeletal Muscle Channelopathies,-,-
Inherited macular dystrophy,-,-
Familial Genetic Generalised Epilepsies,-,-
Rhabdomyolysis and metabolic muscle disorders,-,-
Severe multi-system atopic disease with high lgE,-,-
Undiagnosed metabolic disorders,-,-
Renal tract calcification (or Nephrolithiasis or nephrocalcinosis),-,-
Cone Dysfunction Syndrome,-,-
Charcot-Marie-Tooth disease,-,-
Inherited optic neuropathies,-,-
Extreme early-onset hypertension,-,-
Familial young-onset non-insulin-dependent diabetes,-,-
Leber Congenital Amaurosis or Early-Onset Severe Retinal Dystrophy,-,-
Osteogenesis imperfecta,-,-
Infantile nystagmus,-,-
Hypertrophic Cardiomyopathy,-,-
Syndromic congenital heart disease,-,-
Brain channelopathy,-,-
Familial congenital heart failure,-,-
Multiple bowel polyps,-,-
Disorders of sex development,-,-
Epilepstic encephalopathy,-,-
Non-CF bronchiectasis,-,-
Congenital myopathy,-,-
Inherited white matter disorders,-,-
Genodermatoses with malignancies,-,-
Arrhythmogenic Right Ventricular Cardiomyopathy,-,-
Familial cerebral small vessel disease,inf[0.26-Inf],-
Ear malformations with hearing impairment,-,-
Paediatric motor neuronopathies,-,-
Corneal abnormalities,inf[0.26-Inf],-
,,
Table S1,Univariable and multivariable ORs for association between rare disease groups/specific diseases and COVID-19 related death ,