locus tag;017_WT;2_WT;LM_GLC;PCK_GLC;WT_AC;WT_GLC;017_WT (std);2_WT (std);LM_GLC (std);PCK_GLC (std);WT_AC (std);WT_GLC (std);gene name;descr;COG ID;COG name;cog gene;RefSeq locus;class;kegg gene;kegg description;EC numbers;genbank gene;genebank description;TPM LS/HS;TPM LM/WT;TPM AC/GLC;TPM LS/MS;TPM HS/MS
HELO_1001;449.79080924225536;433.7724842773427;331.7804535013067;381.05007638544583;302.58446821847764;325.4325777974606;17.320410845214216;14.075751057816728;25.732198208011848;2.8219728771706936;10.26937930401157;18.11567249317133;dnaA;chromosomal replication initiator protein DnaA;COG0593;Chromosomal replication initiation ATPase DnaA;DnaA;HELO_RS00005;L;dnaA; chromosomal replication initiator protein DnaA;;dnaA;chromosomal replication initiator protein DnaA;0.052197463536387545;0.027785651813760026;-0.10468706222975577;0.4656730573409451;0.41347559380455756
HELO_1002;400.2025904591014;318.54554957661713;399.42623371025985;414.7200829794744;439.2131337547077;404.55429020821407;8.584626145257618;5.46570372837384;30.878931811249007;22.355894379608145;37.30193058283066;25.821671966428813;dnaN;DNA polymerase 3 beta subunit;COG0592;DNA polymerase III sliding clamp (beta) subunit, PCNA homolog;DnaN;HELO_RS00010;L;dnaN; DNA polymerase 3 beta subunit;2.7.7.7;dnaN;DNA polymerase 3 beta subunit;0.32830932648294464;-0.01835856150916193;0.11830713249223379;-0.015564135091537423;-0.34387346157448206
HELO_1003;301.60934728305983;426.206354844999;335.338689485857;348.55365891868706;292.4145898096512;305.4591555034476;10.902010146765718;19.456611618243993;21.818807542779222;23.60303187678649;8.046852775008976;11.184196805599885;recF;DNA replication and repair protein RecF;COG1195;Recombinational DNA repair ATPase RecF;RecF;HELO_RS00015;L;recF; DNA replication and repair protein RecF;;recF;DNA replication and repair protein RecF;-0.49747655621329834;0.1342199374148354;-0.06275419644994074;-0.018238254552116473;0.47923830166118186
HELO_1004;307.51838876590705;466.02340152157745;405.85220282121503;401.44680577019056;394.2304121520474;389.77858910477835;21.31314499205949;43.19707719160691;30.393326068860155;9.691048267135162;11.225202948593127;11.677851601139343;gyrB;DNA gyrase subunit B;COG0187;DNA gyrase/topoisomerase IV, subunit B;GyrB;HELO_RS00020;L;gyrB; DNA gyrase subunit B;5.6.2.2;gyrB;DNA gyrase subunit B;-0.5981383604753123;0.05815337820075683;0.016342539847148174;-0.34099494214199844;0.2571434183333139
HELO_1005;44.06527846491711;65.10549696465316;63.77815766489979;54.69848693245459;50.270137814111;68.66903486064184;2.843924256293108;3.480483003540658;1.748084280908692;3.1235457957273143;3.9950732710379864;5.464404554167728;gmhB;D%2CD-heptose 1%2C7-bisphosphate phosphatase;COG0241;Histidinol phosphatase/D-glycero-mannoheptose bisphosphatephosphatase, HAD superfamily;HisB1/GmhB;HELO_RS00025;E;gmhB; D,D-heptose 1,7-bisphosphate phosphatase;3.1.3.82,3.1.3.83;gmhB;D%2CD-heptose 1%2C7-bisphosphate phosphatase;-0.5527539378556652;-0.10501013999840847;-0.44239880177733415;-0.6285012721380614;-0.07574733428239622
HELO_1006;92.67606578104441;60.51042304390884;124.46767726724806;146.1724073301433;128.8852385666751;115.59804637778696;4.54608323580436;3.766770875354384;8.8677536740954;3.1721916445244056;14.61141149485556;9.67354090527042;HELO_1006;NAD-dependent epimerase/dehydratase;COG0451;Nucleoside-diphosphate-sugar epimerase;WcaG;HELO_RS00030;M;;gmhB;5.1.3.6;HELO_1006;NAD-dependent epimerase/dehydratase;0.6068495883763925;0.10577213170881716;0.15569386196385882;-0.31579122437401885;-0.9226408127504113
HELO_1007;101.83426130697494;122.46444592323614;136.23373136371973;169.66870996488828;131.46786575584602;137.98396399670983;3.661909241477794;2.3794998801909957;4.48858501922204;7.036688933305446;3.8779852678741156;5.603638018067072;HELO_1007;probable glycosyltransferase%2C type 1;COG0438;Glycosyltransferase involved in cell wall bisynthesis;RfaB;HELO_RS00035;M;;;;HELO_1007;probable glycosyltransferase%2C type 1;-0.26377464093573355;-0.018283301736929047;-0.06927600295647451;-0.43459742649525257;-0.17082278555951902
HELO_1008;146.14953098010412;65.02044882214487;86.03332864414767;180.0793052882108;88.68636240884176;94.07179979032323;10.915054575083504;1.4807121345527412;2.5354515468526175;10.592115324553351;9.547335682368045;4.40547542035823;HELO_1008;probable glycosyltransferase%2C type 1;COG0438;Glycosyltransferase involved in cell wall bisynthesis;RfaB;HELO_RS00040;M;;;;HELO_1008;probable glycosyltransferase%2C type 1;1.1562980924057502;-0.1274494980610541;-0.0841288446507864;0.6301935666227045;-0.5261045257830457
HELO_1009;181.85430822525515;212.62448512731544;355.6973483616341;287.10262234755123;337.2877092939749;368.8501513123538;11.07834123376009;6.982686023893285;18.522915679615842;11.486106430726766;15.64686198890111;10.54841655578443;glyS;glycine--tRNA ligase beta subunit;COG0751;Glycyl-tRNA synthetase, beta subunit;GlyS;HELO_RS00045;J;glyS; glycine--tRNA ligase beta subunit;6.1.1.14;glyS;glycine--tRNA ligase beta subunit;-0.22438239637878432;-0.05224037496745737;-0.12869010408803838;-1.016246247640881;-0.7918638512620966
HELO_1010;188.19218115471617;206.24035906209346;337.3406092084253;308.1125724143765;314.84873114837995;356.18911903705083;10.593839578115498;9.74406048519135;34.65520406667729;30.98065413614561;28.422454948823518;23.345714930237992;glyQ;glycine--tRNA ligase alpha subunit;COG0752;Glycyl-tRNA synthetase, alpha subunit;GlyQ;HELO_RS00050;J;glyQ; glycine--tRNA ligase alpha subunit;6.1.1.14;glyQ;glycine--tRNA ligase alpha subunit;-0.13145252140975483;-0.07821178619832558;-0.17745435614432914;-0.9168356657810044;-0.7853831443712496
HELO_1011;196.0314790554713;167.05494148266752;259.1560990515558;284.53446212320836;255.8327015782345;253.65540241205917;6.681282246570546;3.450303332182883;9.808748045959176;11.290239341139765;15.000193171546826;14.915705547731783;hldD;ADP-L-glycero-D-manno-heptose-6-epimerase;COG0451;Nucleoside-diphosphate-sugar epimerase;WcaG;HELO_RS00055;M;hldD; ADP-L-glycero-D-manno-heptose-6-epimerase;5.1.3.20;hldD;ADP-L-glycero-D-manno-heptose-6-epimerase;0.22949317838840777;0.030831206231442643;0.012282583537314373;-0.37012018113430756;-0.5996133595227153
HELO_1012;263.8030336963755;202.21541107869098;204.60142824476802;213.0642492238579;226.37606638908798;206.8183991796775;13.301730317279432;16.68169400689083;11.105063179172737;4.649405664062332;11.385493789896822;10.999464852822209;waaF;ADP-heptose--LPS heptosyltransferase;COG0859;ADP-heptose:LPS heptosyltransferase;RfaF;HELO_RS00060;M;waaF; ADP-heptose--LPS heptosyltransferase;2.4.-.-;waaF;ADP-heptose--LPS heptosyltransferase;0.3819098356420092;-0.015473102257955063;0.1297570153554135;0.3495962616215005;-0.03231357402050872
HELO_1013;106.46228689891284;70.39627276535712;88.71700475911655;93.49004647388772;88.10936713955671;85.84387683293953;2.7931758356626775;1.5330692198878815;2.789075434773372;0.882549433625374;3.976262201925055;1.355753825552899;opgB;phosphoglycerol transferase OpgB;COG1368;Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily;MdoB;HELO_RS00065;M;opgB; phosphoglycerol transferase OpgB;2.7.8.20;opgB;phosphoglycerol transferase OpgB;0.5899097798013679;0.04695732490363813;0.037152963891898594;0.3073344089555281;-0.28257537084583983
HELO_1014;81.22122227535253;51.930239909013146;55.77067939373313;57.6556610828487;69.13168484639267;63.21985291579572;7.37016291287607;2.9746028920766943;1.0559467532421933;4.106797236933085;5.0540212916271985;2.0207752660844185;HELO_1014;probable glycosyltransferase%2C type 2;COG0463;Glycosyltransferase involved in cell wall bisynthesis;WcaA;HELO_RS00070;M;;opgB;;HELO_1014;probable glycosyltransferase%2C type 2;0.6354186256446557;-0.177873353899054;0.12704702696057701;0.35649145789127434;-0.27892716775338133
HELO_1015;179.03786005650463;108.86028464753205;150.93268918791978;170.81344242229216;163.2560273286209;152.8312137234324;4.015199653282159;4.3785343581755205;11.219450891177893;6.897178386403289;15.319817448532648;11.613524815704153;HELO_1015;probable glycosyltransferase%2C type 9;COG0859;ADP-heptose:LPS heptosyltransferase;RfaF;HELO_RS00075;M;;;;HELO_1015;probable glycosyltransferase%2C type 9;0.7126303869660262;-0.01791596134179052;0.09459804212985734;0.22695205327973778;-0.48567833368628843
HELO_1016;147.09089850823068;93.59316809149645;146.72469340560465;169.78961567807153;133.781035914888;129.46247188675105;5.2196281623240806;6.861545470562435;8.916572179141598;7.86428141609949;7.215550644281166;5.2512426458989685;HELO_1016;probable glycosyltransferase%2C type 1;COG0438;Glycosyltransferase involved in cell wall bisynthesis;RfaB;HELO_RS00080;M;;;;HELO_1016;probable glycosyltransferase%2C type 1;0.6466750819601055;0.17927613588794422;0.046982650602566345;0.18284810822366548;-0.46382697373644
HELO_1017;220.6276829684501;142.19337624738867;177.5054840467852;174.92290009298017;144.26183341121862;178.88254342415902;10.854581911271719;7.465997618750576;11.421920267151505;8.130379754404682;8.323889822679432;7.78918710401672;opsX;ADP-heptose--LPS heptosyltransferase OpsX;COG0859;ADP-heptose:LPS heptosyltransferase;RfaF;HELO_RS00090;M;opsX; ADP-heptose--LPS heptosyltransferase OpsX;2.4.-.-;opsX;ADP-heptose--LPS heptosyltransferase OpsX;0.630173337298686;-0.011086790626480436;-0.30839949389764687;0.30108290808019067;-0.3290904292184953
HELO_1018;211.76356435093638;142.3850851634318;175.5962834081653;164.51094353864463;170.58956817846538;165.18790957359332;2.614502143810058;1.995945506211709;9.115170676389551;8.920299768957658;10.80078523574568;5.58680592861257;hldE;D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase;COG2870;ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase;RfaE;HELO_RS00095;M;hldE; D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase;2.7.1.167,2.7.7.70;hldE;D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase;0.5693561477093851;0.08763955314393357;0.04614641893527249;0.35643568358080824;-0.2129204641285769
HELO_1019;150.40507341267144;95.62539821045375;136.62651122354166;141.66118158696597;138.66090795891662;129.8274466407652;1.7646935971729996;1.7235566780949656;8.449416242927072;8.677893636368275;3.346913877135551;3.259449241468194;waaA;3-deoxy-D-manno-octulosonic-acid transferase;COG1519;3-deoxy-D-manno-octulosonic-acid transferase;KdtA;HELO_RS00100;M;waaA; 3-deoxy-D-manno-octulosonic-acid transferase;2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15;waaA;3-deoxy-D-manno-octulosonic-acid transferase;0.6479391894465438;0.07309316610399286;0.09426301761756317;0.21074830976238523;-0.4371908796841586
HELO_1020;197.337336630765;172.4785542742408;260.5335120376482;286.27212263529947;293.8222170653801;258.4440548222019;6.600033125480984;16.276594262004423;5.109743653285531;13.257452418284704;21.568131908804286;13.463195423598552;rpiA;ribose-5-phosphate isomerase A;COG0120;Ribose 5-phosphate isomerase;RpiA;HELO_RS00105;G;rpiA; ribose-5-phosphate isomerase A;5.3.1.6;rpiA;ribose-5-phosphate isomerase A;0.19319896244847712;0.0115723436767734;0.18442176961938195;-0.38746718904054234;-0.5806661514890195
HELO_1021;211.5329999171622;140.66062666391747;222.3199655438743;222.135369927911;206.51718099551553;230.2545939493234;12.308413246256427;2.9495192349169588;15.72071284535878;6.882635185412063;7.8228428998573865;2.410153568326166;ilvA;L-threonine dehydratase;COG1171;Threonine deaminase;IlvA;HELO_RS00110;E;ilvA; L-threonine dehydratase;4.3.1.19;ilvA;L-threonine dehydratase;0.5852480358845158;-0.050369786892931145;-0.1562512388972186;-0.12179516018278846;-0.7070431960673043
HELO_1022;407.5349119851537;201.6732072556423;332.5697363611102;306.4551208632257;396.8848663809243;327.1552422015293;6.52179350922322;15.31310464435364;44.31014185260252;22.79230777219695;55.10084311835924;31.755321019622095;HELO_1022;5-formyltetrahydrofolate cyclo-ligase;COG0212;5-formyltetrahydrofolate cyclo-ligase;FAU1;HELO_RS00115;H;;ilvA;6.3.3.2;HELO_1022;5-formyltetrahydrofolate cyclo-ligase;1.011303989605242;0.02360992395005823;0.27797254692858786;0.3160808913901487;-0.6952230982150933
HELO_1023;180.75967657531626;86.44664182314038;248.65714485494706;172.7400469317037;158.307238842815;214.39700249509897;5.97326705580679;11.048684601731013;46.16428565344039;50.43276832692256;27.63643805110414;22.86046626874189;zapA;cell division protein ZapA;COG3027;Cell division protein ZapA, inhibits GTPase activity of FtsZ;ZapA;HELO_RS00125;D;zapA; cell division protein ZapA;;zapA;cell division protein ZapA;1.0555572857056257;0.21295002206097013;-0.43518634950039115;-0.2449660003943439;-1.3005232860999696
HELO_1024;92.34563210385284;116.91387373476755;168.35489235754022;168.05276208705916;173.6533769943278;167.62405730251677;2.7523074249332815;4.571087000051368;12.516129280759364;6.519981409082597;1.5880195432920376;12.577411576056466;HELO_1024;UPF0149 family protein;COG3079;Uncharacterized conserved protein YgfB, UPF0149 family;YgfB;HELO_RS00130;S;;zapA;;HELO_1024;UPF0149 family protein;-0.33707905414453787;0.006239286523689991;0.050684160330576766;-0.8531559562527917;-0.5160769021082539
HELO_1025;79.77632547435748;73.54740503220104;86.597116055918;99.67586817863123;98.22029963065904;89.97920493089838;2.9576267976345307;2.234392062765;4.794655176252599;3.6479685558473878;4.191001865098523;5.652995724648219;pepP;Xaa-Pro aminopeptidase;COG0006;Xaa-Pro aminopeptidase;PepP;HELO_RS00135;E;pepP; Xaa-Pro aminopeptidase;3.4.11.9;pepP;Xaa-Pro aminopeptidase;0.11577438544892882;-0.054653453924476736;0.1250984870195584;-0.1716043077966738;-0.2873786932456026
HELO_1026;115.73320450490367;85.42704362837476;135.79347778758802;169.0988626381738;143.90326759531692;133.12873711461114;2.504880903567336;2.9904281941480937;7.87783036042846;4.863849439234225;8.412278263463202;4.99208092615176;ubiH;2-octaprenyl-6-methoxyphenyl hydroxylase;COG0654;2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases;UbiH;HELO_RS00140;CH;ubiH; 2-octaprenyl-6-methoxyphenyl hydroxylase;1.14.13.-;ubiH;2-octaprenyl-6-methoxyphenyl hydroxylase;0.43366027332743595;0.028381077101813368;0.11147176017667704;-0.20040337725095103;-0.634063650578387
HELO_1027;190.40239177313597;87.81497515877099;156.6525682434614;191.55183637873222;182.55777548488823;142.12907411327308;5.726634001248902;5.092686273490103;10.632610885369637;5.982207988891776;9.505235690856164;5.675049405198428;ubiF;2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinolhydroxylase;COG0654;2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases;UbiH;HELO_RS00145;CH;ubiF; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinolhydroxylase;1.14.13.240;ubiF;2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinolhydroxylase;1.1077340018427302;0.13943191292985269;0.3589174685713621;0.4192920983747763;-0.6884419034679539
HELO_1028;197.94899141155418;112.73275719232471;193.19000201181893;179.94754902409807;175.33800537172218;209.99137078883305;3.5987288795517363;5.291806066284976;15.47835301146915;10.738124611921739;17.419060001689015;8.123704841492017;ctpA;CtpA family serine protease;COG0793;C-terminal processing protease CtpA/Prc, contains a PDZ domain;CtpA;HELO_RS00150;O;ctpA; CtpA family serine protease;3.4.21.102;ctpA;CtpA family serine protease;0.806750747557671;-0.11971507155488581;-0.25884055018221197;-0.08478541102082637;-0.8915361585784973
HELO_1029;213.19963297895472;222.06536827984428;190.82947809963025;151.3733558440128;206.3959634085838;179.3545357930528;5.852533457763118;15.345406158288252;9.273755724576251;5.926851638804061;2.439460356963342;12.775030688837452;HELO_1029;peptidase M23 family protein;COG4942;Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB;EnvC;HELO_RS00155;D;;ctpA;;HELO_1029;peptidase M23 family protein;-0.05851053914783044;0.08898872743565533;0.20155210857233552;0.24812030172593058;0.306630840873761
HELO_1030;323.73342855664447;341.65545932178884;525.9803540825685;418.06241179054064;568.7482822091537;515.0660581560422;23.37516203385041;13.750898004622384;23.147437976427785;14.41449024389041;27.745304913672616;45.083146678083835;gpmI;phosphoglycerate mutase%2C 2%2C3-bisphosphoglycerate-independent;COG0696;Phosphoglycerate mutase (BPG-independent), AlkP superfamily;GpmI;HELO_RS00160;G;gpmI; phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent;5.4.2.12;gpmI;phosphoglycerate mutase%2C 2%2C3-bisphosphoglycerate-independent;-0.07750276726174476;0.03019343175988176;0.14276892258408225;-0.668299841681657;-0.5907970744199122
HELO_1031;438.9295659299308;438.3843627874544;494.4949255982867;345.9670969578287;420.0799989367629;502.1205645947991;17.547567205139682;55.08261245619149;27.418815834575266;13.635872722932666;31.508832941808375;51.3831373606731;yibN;rhodanese domain protein YibN;COG0607;Rhodanese-related sulfurtransferase;PspE;HELO_RS00165;P;yibN; rhodanese domain protein YibN;;yibN;rhodanese domain protein YibN;0.0017890356220569004;-0.022033876937944896;-0.2568098097432472;-0.19363159732796298;-0.19542063295001988
HELO_1032;587.2504834217966;681.8802968917036;653.5163230985103;414.1584903849477;597.1108844225914;597.5874080278345;15.758248184504215;8.794680683633242;16.701578032674735;4.713903475130309;65.94911918844416;46.707328761158244;secB;protein-export protein SecB;COG1952;Preprotein translocase subunit SecB;SecB;HELO_RS00170;U;secB; protein-export protein SecB;;secB;protein-export protein SecB;-0.21520210745600643;0.12886724183476161;-0.0011489584013339993;-0.025131329360736032;0.1900707780952704
HELO_1033;492.7321093557727;599.3545683236206;599.7261465188996;443.3431203171364;589.0450999099209;575.8093967078238;42.76591066250418;44.10227141926506;35.54046653492626;12.43763642678514;44.05435479444907;25.450769472610876;rsmE;16S rRNA (uracil(1498)-N(3))-methyltransferase RsmE;COG1385;16S rRNA U1498 N3-methylase RsmE;RsmE;HELO_RS00175;J;rsmE; 16S rRNA (uracil(1498)-N(3))-methyltransferase RsmE;2.1.1.193;rsmE;16S rRNA (uracil(1498)-N(3))-methyltransferase RsmE;-0.2820863332099055;0.058612790844730256;0.032730563146674996;-0.22436619517378276;0.05772013803612275
HELO_1034;83.74679332284065;47.837168747242025;78.11373316227126;85.89992231053391;95.75098936167096;75.78039807489928;10.090571101818153;4.947809696359035;7.52574161177987;6.230137704949053;15.892695960814532;8.620981517742974;HELO_1034;GntR family transcription regulator;COG2186;DNA-binding transcriptional regulator, FadR family;FadR;HELO_RS00180;K;;rsmE;;HELO_1034;GntR family transcription regulator;0.7951792151803065;0.0431901104050505;0.3335383741371869;0.14242074012340744;-0.6527584750568991
HELO_1035;11.563070559879279;5.082304663052955;16.80705577271051;23.397626755877923;17.966062788461866;16.31681455980301;0.5701344910161382;0.3654184452905374;1.4673564558295709;1.563065738349582;0.6941685099126786;4.040805992948828;HELO_1035;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS00185;G;;;;HELO_1035;TRAP transporter substrate-binding protein;1.0464991307131482;0.04027543055046401;0.13124664752100212;-0.46298445100792396;-1.509483581721072
HELO_1036;6.1255116375468575;2.274475138968047;4.3384276624582725;6.195095151985623;5.393181063356438;5.725150987289408;0.8353499415717006;0.8069321819781637;0.7961975948426948;1.2726746098374757;1.7195447078805228;1.1062886933082843;HELO_1036;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS00190;G;;;;HELO_1036;TRAP transporter small transmembrane protein;1.1217299309993056;-0.33315177349319613;-0.07303270472257584;0.0834269504363605;-1.0383029805629451
HELO_1037;11.691048506574596;5.515377570180984;14.781142846682839;19.32545126114034;14.761697789969494;16.986827526429156;0.9776890311415662;1.5153257380070786;1.3347863036335634;2.437462982285299;2.3298260833672773;3.808035035930206;HELO_1037;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS00195;G;;;;HELO_1037;TRAP transporter large transmembrane protein;0.961890574997784;-0.18873906298584142;-0.19051780515855743;-0.5031294835293347;-1.4650200585271187
HELO_1038;4.733715552664306;1.9338117589547312;10.900088643222723;12.580101445093234;12.956015934854422;10.143459170574632;0.3822566152145901;0.11159003715960385;1.537633918342663;1.3474179593187878;0.3952135445133927;1.7303695572160103;pdxA2;4-hydroxythreonine-4-phosphate dehydrogenase;COG1995;4-hydroxy-L-threonine phosphate dehydrogenase PdxA;PdxA;HELO_RS00200;H;pdxA2; 4-hydroxythreonine-4-phosphate dehydrogenase;1.1.1.262;pdxA2;4-hydroxythreonine-4-phosphate dehydrogenase;0.9666940279406204;0.09477517421866999;0.32469000397742454;-0.9586549059824829;-1.9253489339231034
HELO_1039;13.300078130882312;4.454957015502139;19.47288539188863;23.23888016719368;22.75234640376138;20.641501928121556;0.9160571415704463;0.6809458128635786;1.5301310193372828;0.9078824461719257;0.9884596693358667;2.217533239742196;HELO_1039;mandelate racemase domain protein;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS00205;MR;;pdxA2;4.2.1.90;HELO_1039;mandelate racemase domain protein;1.3903832960138338;-0.08008618005778434;0.13426941262639946;-0.5977775967686236;-1.9881608927824574
HELO_1040;12.864204241207851;3.8482149400780687;13.652595350149724;15.067583551111182;15.935213810459578;14.350727545800929;0.9451249216822964;0.3647172275505428;0.4297893840304882;0.7280379457409416;0.3499121423778055;2.7432377069822342;HELO_1040;DUF1238 family protein;COG3802;Uncharacterized conserved protein GguC, FAA hydrolase family;GguC;HELO_RS00210;S;;;;HELO_1040;DUF1238 family protein;1.5158392473203208;-0.06715080801965456;0.14171916769450243;-0.14694222066548113;-1.662781467985802
HELO_1041;314.3905438315972;126.40386748823617;341.15126312990327;321.5489414125147;262.33477262989965;342.2823896828016;10.884963465512682;7.924689517360581;34.25245233093188;32.71199099695516;5.483059377859415;17.381545476543273;HELO_1041;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS00215;K;;;;HELO_1041;LysR family transcription regulator;1.3077303324078127;-0.0047615758086418936;-0.38249781136845584;-0.12225644392596458;-1.4299867763337772
HELO_1042;17.82368355535972;6.505317854714544;19.893813406158433;27.045392926096373;20.949254562990635;19.23104153141719;1.422020673517078;0.4247419026713414;1.1920718077886867;2.6395450182012636;1.3732388842117291;3.5714971167986227;HELO_1042;probable oxidoreductase (iron-containing alcohol dehydrogenase family);COG1454;Alcohol dehydrogenase, class IV;EutG;HELO_RS00220;C;;;1.1.1.61;HELO_1042;probable oxidoreductase (iron-containing alcohol dehydrogenase family);1.3265638955026042;0.046505233559665626;0.1176013496027819;-0.10402162166011131;-1.4305855171627155
HELO_1043;10.608869265009703;13.040834997374821;132.47099137656514;76.49986646181634;38.98508198601957;136.66293257343258;0.9876351611373613;0.895716297590277;13.302029813600925;11.0483864019518;5.141269990486405;28.548151561855033;HELO_1043;TTT family transporter substrate-binding protein;COG3181;Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC;TctC;HELO_RS00225;C;;;;HELO_1043;TTT family transporter substrate-binding protein;-0.27440127744728926;-0.04461392826677546;-1.783606397361753;-3.5678407867016686;-3.2934395092543793
HELO_1044;29.234679687128832;20.675209688293346;48.647069162780205;27.9707224097384;15.722406160084361;55.02895666525827;2.748569027812954;2.1131262676984;4.470582709946728;5.995972228046794;8.546201424469404;8.264023997890531;HELO_1044;TTT family transporter small transmembrane protein;;;;;;;;;HELO_1044;TTT family transporter small transmembrane protein;0.4801583445401558;-0.1744640748727635;-1.744390178470427;-0.8899683330500698;-1.3701266775902257
HELO_1045;15.31787728663865;10.782666945225051;42.25577794668565;22.623749262386422;14.397835133224243;41.62014793600288;1.2398134336138873;0.6190775589880114;4.958710424819378;1.5480911722544948;4.685605678303279;4.033352640471379;HELO_1045;TTT family transporter large transmembrane protein;COG3333;TctA family transporter;;HELO_RS00235;R;;;;HELO_1045;TTT family transporter large transmembrane protein;0.4697872736979356;0.021357254710429707;-1.4688080720681778;-1.385082204445693;-1.8548694781436286
HELO_1046;34.44953778371574;13.549367382401812;43.27571729366637;36.66793458106736;28.25672261891015;41.503641547209234;0.3982603769713147;0.8432027958757197;3.2330219297731064;6.075106000577856;2.288193080616396;2.7186640399481936;HELO_1046;homolog to lactate dehydrogenase;COG2055;Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family;AllD;HELO_RS00240;C;;;;HELO_1046;homolog to lactate dehydrogenase;1.2848103916876732;0.058929228644471365;-0.5388182853551804;-0.26181963435950895;-1.5466300260471821
HELO_1047;53.19362066691617;14.48566744451547;53.11262092359604;50.25650271066363;49.25047589137633;51.77243722503963;2.514496826343415;0.45030317566190387;1.8680909950196305;1.1797825852485144;5.4945636632158505;4.932233839901394;glxR2;2-hydroxy-3-oxopropionate reductase;COG2084;3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase;MmsB;HELO_RS00245;I;glxR2; 2-hydroxy-3-oxopropionate reductase;1.1.1.60;glxR2;2-hydroxy-3-oxopropionate reductase;1.8071894709131011;0.03618050535458739;-0.07064735479278017;0.03833842253594533;-1.7688510483771558
HELO_1048;311.5901895747315;148.5012648658219;128.79495309354672;110.36117448258351;97.31152340223382;133.3225141167408;17.27723533635965;2.5639034744149907;4.373209300642216;2.8723081370475274;5.0543836849000385;6.7136336259448255;HELO_1048;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS00250;K;;glxR2;;HELO_1048;GntR family transcription regulator;1.0641148105730824;-0.0494668514635892;-0.45026870418366016;1.218571362482094;0.15445655190901153
HELO_1049;12.20916593392071;14.95754757935567;40.13034932437491;30.71317342027524;13.166827849428898;41.76769011692058;0.9569563259781126;0.3617201953646097;5.417146677261422;5.5513792708500675;2.4506574455826344;6.503032860827094;HELO_1049;dehydratase domain protein;COG2721;Altronate dehydratase;UxaA;HELO_RS00255;G;;;4.2.1.42;HELO_1049;dehydratase domain protein;-0.2726995759707944;-0.056317964503873164;-1.5940045345020115;-1.6949819159557977;-1.4222823399850033
HELO_1050;8.737037133980595;5.093919814424758;10.183902555833809;11.813816234370464;8.331829819259404;10.122481923395284;0.8296751513514083;0.39069445751008464;1.198226495996481;0.4330516390349475;0.5359015438072712;0.6126317475914942;HELO_1050;L-galactonate dehydratase;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS00260;MR;;;4.2.1.68;HELO_1050;L-galactonate dehydratase;0.6761123271839886;0.007944942028054403;-0.2532468509637824;-0.19192400475903915;-0.8680363319430278
HELO_1051;64.04423565551923;30.43259777961755;130.47289382670166;143.45576307218724;235.8247910029693;136.05288271168075;6.942608558300516;2.3739999269537524;3.2918984306825703;7.057799072118585;23.567665736523086;24.392398515853234;HELO_1051;TRAP transporter substrate-binding protein (probable substrate D-galactonate);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS00265;G;;;;HELO_1051;TRAP transporter substrate-binding protein (probable substrate D-galactonate);1.0491596981254423;-0.059967288237245064;0.7890874377959447;-1.0752395601840643;-2.1243992583095066
HELO_1052;35.15487281599718;17.508109583013802;30.2909047791108;27.107281491874474;68.20254772059114;33.803982206755784;5.832745073124982;1.5902162394055954;3.6129852383785193;2.4781386718866663;22.02395874530734;4.722555003489898;HELO_1052;TRAP transporter small transmembrane protein (probable substrate D-galactonate);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS00270;G;;;;HELO_1052;TRAP transporter small transmembrane protein (probable substrate D-galactonate);0.9660325552556719;-0.15350901116618587;0.9915727662629097;0.05493771522600355;-0.9110948400296683
HELO_1053;33.881383482912746;14.098564494570434;26.88060241086576;29.110820883058846;52.033462197222654;31.01255269039631;4.137084678879152;1.7074097372330241;3.694566677115817;4.8238123563512385;6.314912177857722;7.048802394365163;HELO_1053;TRAP transporter large transmembrane protein (probable substrate D-galactonate);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS00275;G;;;;HELO_1053;TRAP transporter large transmembrane protein (probable substrate D-galactonate);1.2080458712030664;-0.19937598881858243;0.7282652129877816;0.12381953974471926;-1.0842263314583471
HELO_1054;23.92499348551978;8.663872353103793;17.55441190125285;18.52472190089715;31.978034791130156;18.333268346862813;0.35908983062372546;0.9858507997386673;0.9258824993214206;1.98681768113428;0.7368870277477273;2.0866537296918994;HELO_1054;FAD-dependent oxidoreductase;COG0277;FAD/FMN-containing lactate dehydrogenase/glycolate oxidase;GlcD;HELO_RS00280;C;;;;HELO_1054;FAD-dependent oxidoreductase;1.366919823736421;-0.05932327583503483;0.7704198789690277;0.366507577475609;-1.000412246260812
HELO_1055;35.821381597255424;9.804187240881893;23.58033952570608;25.752623995059963;38.49248651028332;24.929643890821534;3.4953515545224696;1.0872931101952077;1.5557319632140993;2.2429706376242633;0.559650782435005;4.124270320125516;xylX2;2-keto-3-deoxyxylonate dehydratase;COG3970;Fumarylacetoacetate (FAA) hydrolase family protein;;HELO_RS00285;R;xylX2; 2-keto-3-deoxyxylonate dehydratase;;xylX2;2-keto-3-deoxyxylonate dehydratase;1.768953212276032;-0.07709754918264622;0.6069758122219682;0.505941367104394;-1.2630118451716381
HELO_1056;46.99557123538468;18.566738493839797;56.925319325066084;47.99260292502603;116.68441405753833;54.30664519780882;1.4760615588200716;1.7984697345875424;3.643311691902236;0.889019232908852;1.4639310818931799;5.056616736255257;HELO_1056;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS00290;I;;xylX2;1.2.1.26;HELO_1056;aldehyde dehydrogenase;1.2944979895076285;0.06674125885420779;1.089398526200081;-0.20455154531303332;-1.4990495348206618
HELO_1057;148.83339232872945;77.39654686546594;131.11029330354097;116.49445377931427;138.18713660031577;133.0349625303281;5.8121354430527745;1.8292945878076337;3.0637117919177945;6.843847953999859;6.8970246272031615;7.318463425663498;HELO_1057;YitL family protein;COG2996;Predicted RNA-binding protein YitL, contains S1 domains, virulence factor B family;CvfB;HELO_RS00295;R;;;;HELO_1057;YitL family protein;0.934497168635013;-0.020866493719585932;0.054416514823357076;0.160749811561673;-0.77374735707334
HELO_1058;326.1726063962448;136.01512386969776;278.96627629142625;239.43970655214534;265.3873465590004;287.85523146264984;4.197885431595582;4.301057513965028;26.37064831542843;14.979552664170741;23.517218302307004;3.365940501446841;gshB;glutathione synthetase;COG0189;Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily;LysX;HELO_RS00300;JEHQ;gshB; glutathione synthetase;6.3.2.3;gshB;glutathione synthetase;1.2557168108121717;-0.04509356769804462;-0.11682106779770685;0.17970533535138777;-1.076011475460784
HELO_1059;389.56958300049456;306.6901181972053;383.1772102209632;364.50454132609957;335.8721962804738;356.7770716847404;8.000354465316681;4.825146681701407;3.664807991316138;2.369699377062545;15.00158073103796;12.092913681828227;algH;UPF0301 family protein;COG1678;Putative transcriptional regulator, AlgH/UPF0301 family;AlgH;HELO_RS00305;K;algH; UPF0301 family protein;;algH;UPF0301 family protein;0.3441014878817157;0.10271100487040741;-0.08685957389400656;0.1265186640283531;-0.21758282385336258
HELO_1060;337.81499129275414;253.50387168478758;163.66205126952354;157.4662489743126;156.1587976878136;175.9833448444492;13.881711747524566;16.82122388522677;2.9449747352513684;8.04327126397813;4.060678303808995;11.175207160849043;yqgF;probable pre-16S rRNA nuclease YqgF;COG0816;YqgF/RuvX protein, pre-16S rRNA maturation RNase/Holliday junction resolvase/anti-termination factor;YqgF;HELO_RS00310;JKL;yqgF; probable pre-16S rRNA nuclease YqgF;3.1.-.-;yqgF;probable pre-16S rRNA nuclease YqgF;0.4128101062083127;-0.10410549713946171;-0.17139056485584003;0.9368841091723255;0.5240740029640127
HELO_1061;73.2159970536383;46.93717133372726;59.60655281310259;73.4074338223072;76.92675891920783;58.9664615652246;2.9101594084226106;1.732901718234693;3.268262344493498;1.127499257286713;10.832137799519765;3.714240685707042;HELO_1061;uncharacterized protein;;;;;;;;;HELO_1061;uncharacterized protein;0.6305854080447526;0.015317940736945701;0.3779629675649172;0.307574342946773;-0.3230110650979796
HELO_1062;138.09081519003306;100.86700604323629;135.57157122203995;116.99979470510267;145.10332469501205;152.29976269940065;8.78559659779191;3.6674129483376148;9.081266718112417;7.71845437696882;4.257440466303447;0.5299129093823449;pyrB;aspartate carbamoyltransferase;COG0540;Aspartate carbamoyltransferase, catalytic subunit;PyrB;HELO_RS00320;F;pyrB; aspartate carbamoyltransferase;2.1.3.2;pyrB;aspartate carbamoyltransferase;0.4493403061049177;-0.16669826071531624;-0.06936645561155075;-0.140328308578467;-0.5896686146833847
HELO_1063;19.766638497443402;12.516619824316164;12.868993924787679;11.129458125803486;12.255339944820243;13.614502212558195;0.4327517168524657;0.046145960845847205;0.3461077690709733;0.6189132247864223;0.2676782729237505;1.2048855630110293;HELO_1063;YjiR family protein;COG1167;DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain;ARO8;HELO_RS00325;KE;;pyrB;;HELO_1063;YjiR family protein;0.6195332915472309;-0.07553755361487058;-0.14082702020109616;0.5068670155032287;-0.11266627604400226
HELO_1064;37.997007716402656;17.674483438112578;53.770066025204216;89.39721011949054;74.60200267664736;50.39293985883635;1.3390506806905311;1.9775454476797183;8.15889240039285;4.009207431102285;9.994912308552692;3.322357517144857;HELO_1064;PhzF family protein;COG0384;Predicted epimerase YddE/YHI9, PhzF superfamily;YHI9;HELO_RS00335;R;;;5.3.3.17;HELO_1064;PhzF family protein;1.0622950919951712;0.09181743774547346;0.5568542697668182;-0.39820675315476706;-1.4605018451499383
HELO_1065;70.30310861216967;50.121340350537025;31.1091715687827;52.91143885182907;24.640509479900384;28.118088946793605;2.9874578096932427;1.7715198642564236;3.492943438416344;3.5148292099481626;3.2170054308325065;2.3623037227092816;HELO_1065;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS00340;G;;;;HELO_1065;major facilitator superfamily transport protein;0.4800393126240028;0.1410697704245667;-0.1834907441722189;1.2920493024976558;0.812009989873653
HELO_1066;20.06951814480026;20.766366303697584;22.09690394600929;24.322875648856535;24.537149361588018;21.320645166527502;2.694414433013582;0.634554553132073;2.9759982544041694;1.5257309709668165;0.5900419999083605;1.9439012703648533;maiA;maleylacetoacetate isomerase;COG0625;Glutathione S-transferase;GstA;HELO_RS00345;O;maiA; maleylacetoacetate isomerase;5.2.1.4;maiA;maleylacetoacetate isomerase;-0.04694326243305458;0.04932074858981128;0.1942187620249758;-0.08322140769496134;-0.03627814526190676
HELO_1067;3.967981212051528;11.816264706325198;13.600503872032164;8.628289735491151;14.631726756460054;13.591433660781762;0.2692194882542341;1.155159385613462;1.195860931463458;1.042123598096232;2.4435298542779487;0.48134519964920885;HELO_1067;fumarylacetoacetate hydrolase domain protein;COG0179;2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway);YcgM;HELO_RS00350;Q;;maiA;3.7.1.2;HELO_1067;fumarylacetoacetate hydrolase domain protein;-1.3672442278131585;0.0008965180332518585;0.09935551405066123;-1.55439001750465;-0.18714578969149143
HELO_1068;3.20325350000337;7.923416391347815;8.471752950978525;6.0087116073674025;8.916076792847358;9.486038873735623;0.19216144640114036;0.36780325106236667;1.0117164918724804;0.6929275614588691;1.0413088686627079;1.5274983971198872;hmgA;homogentisate 1%2C2-dioxygenase;COG3508;Homogentisate 1,2-dioxygenase;HmgA;HELO_RS00355;Q;hmgA; homogentisate 1,2-dioxygenase;1.13.11.5;hmgA;homogentisate 1%2C2-dioxygenase;-1.0860896929633705;-0.1467664421526913;-0.08062845011022102;-1.3188914255441238;-0.2328017325807532
HELO_1069;35.17784210243132;13.278247700269134;35.24205536214325;33.128948478391486;31.537534641382962;33.5265336020388;2.3500575734465756;1.074517021531366;2.0699124317314683;3.0365170224698774;1.0222378730461337;4.402194850860919;HELO_1069;MarR family transcription regulator;COG1846;DNA-binding transcriptional regulator, MarR family;MarR;HELO_RS00360;K;;hmgA;;HELO_1069;MarR family transcription regulator;1.3412874228794949;0.06995927829482973;-0.08560055502943076;0.06740086054316219;-1.2738865623363327
HELO_1070;313.88427954242644;283.0928320760599;426.41751389027917;398.0038528178093;1017.0089999095659;423.2638815524595;22.314427268144012;8.740438759080124;27.461547168343;36.808236235295574;22.25341677146779;8.08759183079431;iclR;IclR family transcription regulator IclR;COG1414;DNA-binding transcriptional regulator, IclR family;IclR;HELO_RS00365;K;iclR; IclR family transcription regulator IclR;;iclR;IclR family transcription regulator IclR;0.14845930190173284;0.010684160891134553;1.2627165464958878;-0.4301401309287378;-0.5785994328304707
HELO_1071;82.64338327010476;57.44790564573608;112.13915114359934;125.01425483563783;206.7162448893912;102.77152493271127;5.691276864901243;3.5730538471830786;9.196065204992703;7.835777859306817;4.399449409194025;6.510525452741627;HELO_1071;response regulator/sigma-54-interact/HTH domain transcription regulator;COG2204;DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains;AtoC;HELO_RS00370;T;;iclR;;HELO_1071;response regulator/sigma-54-interact/HTH domain transcription regulator;0.5171000884882337;0.12468763168869224;1.0012034293745176;-0.31108729681713587;-0.8281873853053696
HELO_1072;21.680653421703642;13.398469318698735;22.25218836278995;27.096023451213764;42.86101307995631;19.863717575875004;1.0982769898909213;1.0288639939954245;1.2414082553730381;1.7668664745972422;0.9509604507331229;0.48174049046372447;HELO_1072;sensor histidine kinase;COG4191;Signal transduction histidine kinase regulating C4-dicarboxylate transport system;;HELO_RS00375;T;;;2.7.13.3;HELO_1072;sensor histidine kinase;0.6555467555084333;0.15637025519890368;1.0719428894462553;0.12046595881352395;-0.5350807966949094
HELO_1073;16.067117269970847;4.9607355867528575;26.81017194607605;61.900196537924096;87.71631101004277;28.354322284537897;3.0176008103549887;0.36678010183990484;5.289026793248323;9.378977178927242;37.74019663368753;3.392044851070963;HELO_1073;major facilitator superfamily transport protein;;;;;;;;;HELO_1073;major facilitator superfamily transport protein;1.5176571167160788;-0.07796028429235502;1.5956264278225012;-0.782353549158211;-2.30001066587429
HELO_1074;7.994600310378556;4.796157180097896;60.156718401438575;47.28941826362944;46.540649089492064;60.67640894794686;0.626115447671106;0.45667365450510145;1.2927206063746275;3.2062793428564444;4.815553536294816;7.184374513665579;HELO_1074;NCS2 family transport protein;COG2233;Xanthine/uracil permease;UraA;HELO_RS00385;F;;;;HELO_1074;NCS2 family transport protein;0.6339624560057198;-0.012207772676100959;-0.37555716706307063;-2.7775876885847093;-3.411550144590429
HELO_1075;17.763942513913463;9.756642261555138;27.211871869807453;30.843976027820734;22.389387907385245;23.877361052379698;1.3902631790888347;0.4215160804072405;1.1634391950247982;1.3532771292996202;1.7047594825762826;2.972964310242597;HELO_1075;8-oxoguanine deaminase;COG0402;Cytosine/adenosine deaminase or related metal-dependent hydrolase;SsnA;HELO_RS00390;FR;;;3.5.4.32;HELO_1075;8-oxoguanine deaminase;0.8027351821840307;0.18146893755501914;-0.08897934765140914;-0.40687046893372614;-1.2096056511177569
HELO_1076;26.581198992217864;8.003114035260234;835.7442306776857;1088.5968721789225;273.4047302047866;571.498262321156;0.8164737497239565;0.693179671457479;172.4998120330468;56.57509417296996;215.10395812734174;484.7537184131216;HELO_1076;homolog to spore coat protein U;COG5430;Fimbrial subunit ScuA/B, ScuA/B/SCPU domain;SCPU;HELO_RS00395;W;;;;HELO_1076;homolog to spore coat protein U;1.6151891757775179;0.5475153843467595;-1.06096596328074;-4.375514235024733;-5.990703410802251
HELO_1077;27.994119488213215;6.293055864081189;153.56253502083152;180.1373050671664;35.05565946901152;85.61430452565435;0.902625082399703;0.42990424089447266;34.75972208111395;41.53988249418457;25.683357598499704;70.89532698070443;HELO_1077;homolog to spore coat protein U;COG5430;Fimbrial subunit ScuA/B, ScuA/B/SCPU domain;SCPU;HELO_RS00400;W;;;;HELO_1077;homolog to spore coat protein U;1.9911649761156744;0.8355134477879433;-1.264379579036608;-1.5788449823423125;-3.570009958457987
HELO_1078;14.41982883375812;6.319320218198008;120.31363497234987;147.23604850268526;37.73203979296883;84.86026051204942;1.5742822965271468;0.07219164428322838;24.122100335284724;7.803326886398177;25.194381652726953;67.63716518263324;HELO_1078;probable usher pathway chaperone;COG3121;P pilus assembly protein, chaperone PapD;FimC;HELO_RS00405;W;;;;HELO_1078;probable usher pathway chaperone;1.0750051812979482;0.49867925516102574;-1.1484630683437294;-2.4772037992788447;-3.552208980576793
HELO_1079;20.513014199880406;6.427644704773566;66.57699889966732;87.75997559161486;25.32928517367959;46.744013726703336;1.7207076796710425;0.6473485082297975;9.8269135299517;5.23270439320877;14.108659082549316;34.45680597642096;HELO_1079;outer membrane usher protein;COG3188;Outer membrane usher protein FimD/PapC;FimD;HELO_RS00410;NW;;;;HELO_1079;outer membrane usher protein;1.5342329637785532;0.5012124262237982;-0.8586515019897822;-1.1501101797959157;-2.684343143574469
HELO_1080;21.24201282584026;6.830970962823867;22.065587193001736;33.353201332890656;13.890192349825275;15.676390839307004;0.62042635443314;0.24671311202631932;4.0403142018675595;1.868728555311323;3.503573478183542;9.15016304074016;HELO_1080;homolog to spore coat protein U;COG5430;Fimbrial subunit ScuA/B, ScuA/B/SCPU domain;SCPU;HELO_RS00415;W;;;;HELO_1080;homolog to spore coat protein U;1.506024249307215;0.4679349306877505;-0.16344469903114955;0.4154802632767822;-1.0905439860304327
HELO_1081;598.211779800425;1337.5549146749877;2122.1480722257675;1511.8027669286314;1159.4332804014582;2224.770655869199;44.62089727696177;27.602585448870702;169.8849176251262;55.45468228998924;137.44244234982457;50.143643135413896;serA;D-3-phosphoglycerate dehydrogenase;COG0111;Phosphoglycerate dehydrogenase or related dehydrogenase;SerA;HELO_RS00420;H;serA; D-3-phosphoglycerate dehydrogenase;1.1.1.95,1.1.1.399;serA;D-3-phosphoglycerate dehydrogenase;-1.1595384363726247;-0.06809995363271071;-0.9396413678629063;-1.8931670536932383;-0.7336286173206137
HELO_1082;162.52288261813487;176.6887843086985;155.83992642955408;133.96657153608714;106.16414955484623;111.06418921106194;26.17244539778061;66.4901766006979;31.48662897264354;48.09763800555925;17.055877080310164;13.714926562710886;xseB;exodeoxyribonuclease 7 small subunit;COG1722;Exonuclease VII small subunit;XseB;HELO_RS00425;L;xseB; exodeoxyribonuclease 7 small subunit;3.1.11.6;xseB;exodeoxyribonuclease 7 small subunit;-0.11986008776565082;0.4849675403587801;-0.06450297920267545;0.5451672038954616;0.6650272916611124
HELO_1083;407.60403559468597;333.7584949232459;273.66119108451426;302.02216289084663;268.62470083554456;278.82145637771714;10.314394037820946;10.779717284931177;6.425832423808087;5.103942386656131;11.395183903294784;4.350566286644829;ispA;farnesyl diphosphate synthase;COG0142;Geranylgeranyl pyrophosphate synthase;IspA;HELO_RS00430;H;ispA; farnesyl diphosphate synthase;2.5.1.1,2.5.1.10,2.5.1.29;ispA;farnesyl diphosphate synthase;0.28758278674027515;-0.02685351515198775;-0.05355392025878558;0.5461968620884008;0.25861407534812564
HELO_1084;306.9260685700587;236.27766439260495;301.1316262712566;308.24311237603297;276.90706020715487;286.2301905591128;12.200102796748903;6.125881516346315;11.902556532633188;6.750306367006963;3.5256157153475645;9.65366271044013;dxs;1-deoxy-D-xylulose-5-phosphate synthase;COG1154;Deoxyxylulose-5-phosphate synthase;Dxs;HELO_RS00435;HI;dxs; 1-deoxy-D-xylulose-5-phosphate synthase;2.2.1.7;dxs;1-deoxy-D-xylulose-5-phosphate synthase;0.3760077069815084;0.07296981137460534;-0.047604911212047796;0.10037661123163488;-0.27563109574987354
HELO_1085;269.1453468849036;208.61070635183012;226.12449974683716;220.69724004803697;204.18705876164904;205.15293989596432;7.803697259717064;12.385064465403893;15.075966120609499;15.918188480800803;5.481764453266077;9.729530746093436;djlA;co-chaperone protein DjlA;COG1076;DnaJ domain-containing protein;DjlA;HELO_RS00440;O;djlA; co-chaperone protein DjlA;;djlA;co-chaperone protein DjlA;0.36602342475223804;0.1397683015653497;-0.006775292887620132;0.3900207972079759;0.023997372455737853
HELO_1086;113.8962896260259;118.74903988744039;101.0031620448883;96.4636128833857;102.87969990948558;114.55654253104991;3.434476127150662;3.1997900103944654;11.863768088180134;10.552406579550304;4.311611071144273;8.52248115924816;HELO_1086;NhaC family sodium/proton antiporter domain protein;COG1757;Na+/H+ antiporter NhaC/MleN;NhaC;HELO_RS00445;C;;djlA;;HELO_1086;NhaC family sodium/proton antiporter domain protein;-0.05968187947101189;-0.17998506832586258;-0.1536851925724454;-0.008266734578022294;0.051415144892989595
HELO_1087;401.25705674164556;118.52877164612717;132.10398436395676;66.29351587400544;53.44200264498602;109.43843183661569;15.655176490466049;11.601478000331916;13.426925390649572;10.784190799792407;10.425643655344;26.245482683363193;HELO_1087;uncharacterized protein;;;;;;;;;HELO_1087;uncharacterized protein;1.7507598005476739;0.2693114501180478;-1.0204502653693757;1.8648754224475574;0.11411562189988356
HELO_1088;223.23657128754348;134.98934724721562;210.24480885214214;186.00450479044238;279.15588949804106;214.97864056896685;10.642439956372838;11.006510950591643;21.17490951962525;7.904191096121427;21.108203965625663;15.731849883690579;ribA;GTP cyclohydrolase 2;COG0807;GTP cyclohydrolase II;RibA;HELO_RS00455;H;ribA; GTP cyclohydrolase 2;3.5.4.25;ribA;GTP cyclohydrolase 2;0.7215279478775907;-0.03197275370512909;0.37534117891062024;0.05413294734894425;-0.6673950005286464
HELO_1089;265.4549297733851;172.043947932777;226.4629018138547;222.71374073046925;231.17793620405936;222.59350368966304;3.5163870974827924;1.5280602009442017;11.028167780870186;6.535887716449201;11.425094821753287;5.233450491983575;hemE;uroporphyrinogen decarboxylase;COG0407;Uroporphyrinogen-III decarboxylase HemE;HemE;HELO_RS00460;H;hemE; uroporphyrinogen decarboxylase;4.1.1.37;hemE;uroporphyrinogen decarboxylase;0.6227530398027463;0.024752994792887506;0.05435260729421376;0.25301325256802;-0.36973978723472634
HELO_1090;213.37960290657028;158.34850073583277;238.53963640864387;200.72124018767988;249.84724402089876;238.87157902109428;8.915067418195479;10.525604497122199;17.119868004883195;4.115609915635255;11.480584314653216;18.607727706346708;speE;spermidine synthase;COG0421;Spermidine synthase (polyamine aminopropyltransferase);SpeE;HELO_RS00465;E;speE; spermidine synthase;2.5.1.16;speE;spermidine synthase;0.4279822021909414;-0.001997834101322482;0.06454685648745873;-0.1620945838007577;-0.5900767859916991
HELO_1091;248.01951955264948;70.4684673091473;102.79337724030553;96.19781239839351;129.70221077893825;113.23321503260779;5.166504693216197;10.181620103982032;5.907340165090489;9.085258843882027;7.56114516271404;8.812212378609837;HELO_1091;uncharacterized protein;;;;;;;;;HELO_1091;uncharacterized protein;1.8008800791677668;-0.13826780469930888;0.19430134691444056;1.124276636218143;-0.6766034429496237
HELO_1092;26.558688722827767;17.474667348123017;31.1459408877403;21.8295428986706;25.334694089182022;28.105921732738597;2.232177535895829;0.3108266333326706;3.8889871722724707;1.0909036404657262;3.0490045953873626;0.9600919903135697;HELO_1092;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS00475;K;;;;HELO_1092;LysR family transcription regulator;0.5769588567540396;0.14332387206909925;-0.14434800503400247;-0.0788054614681144;-0.655764318222154
HELO_1093;604.8336206449984;900.3338937560188;584.3609813456736;294.8203274513485;337.2029980214859;490.5259955229096;73.847303792344;33.28158860861067;97.09405927538758;25.373159647908736;57.90719056363861;74.70174107891437;fpr;ferredoxin--NADP reductase;COG1018;Flavodoxin/ferredoxin--NADP reductase;Fpr;HELO_RS00480;C;fpr; ferredoxin--NADP reductase;1.18.1.2,1.19.1.1;fpr;ferredoxin--NADP reductase;-0.573140000313952;0.25205886367174735;-0.539378270282409;0.30165392355081977;0.8747939238647717
HELO_1094;70.93736675859074;14.131752458996374;91.87130092500517;139.4058953576574;143.4918041173684;91.5298837908327;3.934269482751275;0.7474689285572276;12.33367206306027;9.68090737752138;13.34778286737027;5.998643453138379;HELO_1094;TRAP transporter substrate-binding protein (probable substrate D-glucuronate);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS00485;G;;fpr;;HELO_1094;TRAP transporter substrate-binding protein (probable substrate D-glucuronate);2.2491622705258916;0.005313465109535009;0.6429963782306247;-0.36317802786318687;-2.6123402983890784
HELO_1095;7.147984512803579;6.311424623338926;8.133960250088535;7.262201066982879;8.451448154574225;8.859814775074115;1.5352518636776076;0.8538446489491247;1.1421622998347634;1.0629519687620006;2.1577896521576148;0.7830210972550592;HELO_1095;TRAP transporter small transmembrane protein (probable substrate D-glucuronate);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS00490;G;;;;HELO_1095;TRAP transporter small transmembrane protein (probable substrate D-glucuronate);0.1562906969511606;-0.11032003332391227;-0.06102514804891168;-0.27511730649728383;-0.43140800344844443
HELO_1096;5.5088594656745355;3.8520209354669315;7.67892185133357;6.4594897883660485;9.564840963506311;7.9321023673187065;0.8722616027859269;0.40037843239653514;0.0938917553691211;1.2940826304127164;1.7454550922301733;0.3966950523036705;HELO_1096;TRAP transporter large transmembrane protein (probable substrate D-glucuronate);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS00495;G;;;;HELO_1096;TRAP transporter large transmembrane protein (probable substrate D-glucuronate);0.4238189895903446;-0.04148395200303989;0.24219935948019877;-0.45659502042368194;-0.8804140100140265
HELO_1097;18.60712535768477;12.769682196904895;22.19032278769882;14.485288057345256;30.61421642199312;21.348741433699104;0.6259752481722216;0.5885140563042318;1.637341574465559;0.2549832652778527;2.8392889552878415;1.9675753888005798;HELO_1097;glycoside hydrolase domain protein;COG1501;Alpha-glucosidase/xylosidase, GH31 family;YicI;HELO_RS00500;G;;;3.2.1.20;HELO_1097;glycoside hydrolase domain protein;0.5098827718700587;0.0533293125719263;0.5003798733383054;-0.18881555407508444;-0.6986983259451431
HELO_1098;231.42199399739908;237.0444133183133;649.4786966383693;546.7907114136674;558.2986178484717;591.3082032301068;18.231354886936657;39.74589984321647;92.32381725383881;55.806122104056506;29.129712957640134;30.744544739784956;glnK1;nitrogen regulatory protein P-II;COG0347;Nitrogen regulatory protein PII;GlnK;HELO_RS00505;TE;glnK1; nitrogen regulatory protein P-II;;glnK1;nitrogen regulatory protein P-II;-0.034484173737658;0.13515374202872188;-0.0827293019097155;-1.34960147017782;-1.315117296440162
HELO_1099;6.846564109397228;49.64895352986008;14.207932320434578;16.24072004410155;13.664653750307613;14.501280740824692;0.0754020555839292;4.367743484236566;1.6047639465693517;6.540611079544923;2.6218194089179208;1.9310967082443715;HELO_1099;AmtB family transport protein (probable substrate ammonium);COG0004;Ammonia channel protein AmtB;AmtB;HELO_RS00510;P;;glnK1;;HELO_1099;AmtB family transport protein (probable substrate ammonium);-2.6903994982049997;-0.027563401500166673;-0.08004441044261146;-0.9822544549537442;1.7081450432512555
HELO_1100;1.5491282655938006;21.34676926859058;8.979239643874003;10.439601620706004;10.632619974097114;8.473581354099828;0.49332274653030855;3.056046127819352;2.2698567387934596;1.7568734326415683;2.9290610471940526;1.8398506028233579;glnK2;nitrogen regulatory protein P-II;COG0347;Nitrogen regulatory protein PII;GlnK;HELO_RS00515;TE;glnK2; nitrogen regulatory protein P-II;;glnK2;nitrogen regulatory protein P-II;-3.1319903992427074;0.07501997597789423;0.2961942420633923;-1.8939059514646701;1.238084447778037
HELO_1101;226.8260202667487;160.59186141644548;220.3005263207743;147.32729639857874;156.0206778679479;141.18984800444073;11.493906956961874;14.753987989871469;40.85522526363151;45.68624271674981;30.306806659030638;10.987200951676163;HELO_1101;BMFP domain protein;COG2960;Ubiquinone biosynthesis accessory factor UbiK;UbiK;HELO_RS00520;H;;glnK2;;HELO_1101;BMFP domain protein;0.4955779897847199;0.6381884184590652;0.1431360945797806;0.6801140644271726;0.1845360746424527
HELO_1102;79.28131099459019;55.18940880900169;51.04162403306672;60.2273607187279;47.30859042578067;46.38800089520208;1.8011511091825225;5.138607001303828;3.666462947047702;0.8094851828173852;3.3836415573695118;5.908222709967438;comM;ComM family protein;COG0606;Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family;YifB;HELO_RS00525;O;comM; ComM family protein;;comM;ComM family protein;0.5147659549002386;0.1351441832277427;0.027757956760873448;0.7605423752310916;0.245776420330853
HELO_1103;48.821874868644336;24.427105304155642;50.89576592514542;55.70227199041259;38.23610414156364;49.89154014604288;2.4316025303125643;2.136043274168485;2.83666151620566;0.974606992425017;2.4759366204220554;3.3162195551296887;cas1;CRISPR-associated endonuclease Cas1;COG1518;CRISPR-Cas system-associated integrase Cas1;Cas1;HELO_RS00530;V;cas1; CRISPR-associated endonuclease Cas1;;cas1;CRISPR-associated endonuclease Cas1;0.9704120825209026;0.028190984003995112;-0.3752440530984025;-0.030646539406425255;-1.0010586219273279
HELO_1104;19.26947661623762;10.478330623344155;21.36170482017958;24.267629097525916;20.282492594608783;19.12623961224266;1.2320632383156214;0.3803562028732831;0.8630195597916044;1.602406812182492;1.108015016757643;2.1271295214071784;cas3;CRISPR-associated nuclease/helicase Cas3;COG5932;CRISPR-Cas type I-F system-associated endonuclease/helicase Cas3f, fused to Cas2 domain;Cas3f;HELO_RS00535;V;cas3; CRISPR-associated nuclease/helicase Cas3;3.1.-.-,3.6.4.-;cas3;CRISPR-associated nuclease/helicase Cas3;0.8203960013641196;0.15195253689464572;0.08058948422321954;0.010231192844001313;-0.8101648085201183
HELO_1105;83.79008235786067;110.54602650169772;132.63154331181852;137.57981105436423;130.16235634617465;145.57367082122104;0.9782079939885118;8.477349102185656;8.276742551550896;7.8429741506183435;5.922750354936676;20.00604867649445;csy1;CRISPR-associated protein Csy1;;;;;;;;;csy1;CRISPR-associated protein Csy1;-0.395671690691656;-0.13336538224993877;-0.16027224870371892;-0.7896585419067668;-0.3939868512151108
HELO_1106;117.82529822420395;119.31358229523278;130.0378380986277;105.29110996440231;115.40278406238919;124.00025641481585;1.3631462780581292;4.140714403022819;9.196637355623025;11.17072299360759;10.02200075849692;8.782492452802636;csy2;CRISPR-associated protein Csy2;;;;;;;;;csy2;CRISPR-associated protein Csy2;-0.017957496211272073;0.06805240596303186;-0.10280549000875983;-0.0730890318334394;-0.05513153562216733
HELO_1107;237.06590975263921;186.53717749871382;323.197300768524;213.64562665870014;349.2886159779082;334.50808954228677;17.270861361500955;3.715629900272608;10.567221572845307;8.913739759699487;4.813915992125078;8.866092708051466;csy3;CRISPR-associated protein Csy3;;;;;;;;;csy3;CRISPR-associated protein Csy3;0.3441844214460881;-0.0494754729405269;0.06219655066322183;-0.4949865058625198;-0.8391709273086079
HELO_1108;45.03656716467075;51.211542249949396;116.65111924219995;112.63036585488226;175.36401496030308;116.8888941104608;4.378658318450473;3.0216243906695417;10.085171772287318;4.003312364948421;9.590145579407123;13.498459780367243;glpQ;glycerophosphoryl diester phosphodiesterase;;;;;;;;;glpQ;glycerophosphoryl diester phosphodiesterase;-0.18158851513824104;-0.0029127682802672084;0.5811284120687779;-1.3565756492800274;-1.1749871341417863
HELO_1109;152.34795795162782;128.51646167093529;205.809913453028;173.8922345456499;168.70022211205887;178.5911079244299;8.327582563261677;9.567683919636648;19.151223353637313;14.803707499882027;16.94153870752091;11.862474004258894;HELO_1109;DUF4202 domain protein;;;;;;;;;HELO_1109;DUF4202 domain protein;0.24367347763692493;0.20358942319536144;-0.08172746668756403;-0.2279069646644425;-0.4715804423013674
HELO_1110;140.42502679851654;102.85554514997425;95.18725763969938;72.67688111821273;73.94507493117725;87.35138853795998;6.984663863966966;8.788287557140018;7.079933867260537;3.1179508306625774;8.703318978650376;5.214809539025317;HELO_1110;uncharacterized protein;;;;;;;;;HELO_1110;uncharacterized protein;0.4454591964285619;0.1225929778543069;-0.23741913491440148;0.6787127307708092;0.23325353434224727
HELO_1111;87.64656291131071;134.86165892513338;85.85421484573442;68.49730280125505;47.10833418710905;89.34696619748689;5.005572838537705;2.0416745351302565;10.758429813006963;1.3365701912351395;2.419543473829917;11.476465482000073;HELO_1111;SDF family transport protein;COG1301;Na+/H+-dicarboxylate symporter;GltP;HELO_RS00575;C;;;;HELO_1111;SDF family transport protein;-0.6160017755099512;-0.05688029549979312;-0.9091893118646865;-0.027411462313319923;0.5885903131966312
HELO_1112;35.9571822825913;18.275940671703435;37.137330065201674;63.92578583915844;57.76899163534918;32.26151955293219;2.8117094852057294;1.6314134284075665;2.9233795699376293;8.788866167282887;6.298580881811741;0.7565993974502402;HELO_1112;alpha/beta hydrolase fold protein (homolog to dienelactone hydrolase);COG0412;Dienelactone hydrolase;DLH;HELO_RS00580;Q;;;;HELO_1112;alpha/beta hydrolase fold protein (homolog to dienelactone hydrolase);0.9390535000915898;0.19734976669220572;0.8212010649514845;0.15200068623025942;-0.7870528138613304
HELO_1113;102.87611334666313;75.50883768260239;231.68293312350758;261.24683520036274;286.2874777289166;242.89361203502781;5.180460103953219;5.46827349919068;11.21759465223621;27.789462442412102;7.779042409441344;54.91556797870938;HELO_1113;ABC-type transport system periplasmic substrate-binding protein;COG0683;ABC-type branched-chain amino acid transport system, periplasmic component;LivK;HELO_RS00585;E;;;;HELO_1113;ABC-type transport system periplasmic substrate-binding protein;0.4411656289031747;-0.06788657660533293;0.23624313799593644;-1.231388032212947;-1.6725536611161216
HELO_1114;10.2755309178385;12.464022051424067;34.39206594202562;49.083591756686786;28.1241779307673;36.10991785483919;0.6537200961782254;0.8374585763343462;0.6744147178611356;4.091207900053125;2.438433334532164;4.5308570662879655;HELO_1114;ABC-type transport system permease protein;COG4177;ABC-type branched-chain amino acid transport system, permease component;LivM;HELO_RS00590;E;;;;HELO_1114;ABC-type transport system permease protein;-0.2559140790465384;-0.06837882884390822;-0.34958747921503885;-1.718609441954786;-1.4626953629082475
HELO_1115;6.996737524772715;6.985083707677059;30.046446124556002;40.64910717186252;21.19296092867382;32.1808019722572;0.4305657030145896;0.5167248449081361;2.0865197457269713;5.24207486894232;2.085141523548104;5.261825546476207;HELO_1115;ABC-type transport system permease protein;COG0559;Branched-chain amino acid ABC-type transport system, permease component;LivH;HELO_RS00595;E;;;;HELO_1115;ABC-type transport system permease protein;0.0021040039012723;-0.0959206232001435;-0.5802465952214533;-2.0528653158085186;-2.054969319709791
HELO_1116;15.42390016567029;17.284143793695364;39.58760023774474;50.01732556508906;23.36849764351202;38.68851984697481;1.0197301634745635;2.534141469341815;5.452630346298982;6.310456676297621;3.830647301579499;8.718517527692143;HELO_1116;ABC-type transport system ATP-binding protein;COG0410;ABC-type branched-chain amino acid transport system, ATPase component LivF;LivF;HELO_RS00600;E;;;;HELO_1116;ABC-type transport system ATP-binding protein;-0.15479630700137204;0.03231728335640849;-0.7037044497637837;-1.272924996112863;-1.118128689111491
HELO_1117;18.369490597173737;17.6951659181675;35.03132946169645;47.85214037304621;25.667885225087357;39.077485406542976;0.9812688814728954;0.8134802416669776;1.0677097181248443;3.8195477117323158;2.488874300889937;5.159904507627848;HELO_1117;ABC-type transport system ATP-binding protein;COG0411;ABC-type branched-chain amino acid transport system, ATPase component LivG;LivG;HELO_RS00605;E;;;;HELO_1117;ABC-type transport system ATP-binding protein;0.051120737600061084;-0.15354010751779068;-0.5876885688536015;-1.049005979272284;-1.100126716872345
HELO_1118;16.967671622192828;29.358225339465992;23.978770650774212;22.55626480754618;14.907525235854676;23.362855152529306;0.2806662667955625;3.022584114826073;1.1882795199844773;1.9734467865633665;3.6082145321579224;1.4484857626486518;HELO_1118;NSS family transport protein;COG0733;Na+-dependent transporter, SNF family;YocR;HELO_RS00610;R;;;;HELO_1118;NSS family transport protein;-0.7566839907846274;0.03601925865604727;-0.6149738064045018;-0.4392797503554755;0.31740424042915194
HELO_1119;31.927762893909534;50.13730467082214;72.51089052824472;65.21487754519897;82.87205708066817;70.76576157923624;2.0388032781711254;2.621415981521181;6.245868308460076;2.862519537770812;10.322157842600133;3.1567075210903113;HELO_1119;uncharacterized protein;;;;;;;;;HELO_1119;uncharacterized protein;-0.6350716226313633;0.03466227992488591;0.22489452166627633;-1.1239912201358147;-0.48891959750445135
HELO_1120;168.56666595377413;48.8587384301945;184.16666707412557;183.6909067795497;172.6965267962112;164.47635256630554;3.6398608375947976;4.835195802716212;43.1962304377471;35.514819341443285;39.89970993137392;20.165301015227588;HELO_1120;uncharacterized protein;;;;;;;;;HELO_1120;uncharacterized protein;1.7659343033533874;0.16219935095007543;0.06994384335436177;0.03522752429622056;-1.7307067790571669
HELO_1121;525.2228704104405;676.0860164501422;896.0354831708695;767.0090567649045;997.2080557346177;904.9303816998868;19.9728323923797;43.90002999218002;111.4615386348944;68.5145012069586;148.67316203607334;103.39206038366179;typA;GTP-binding protein TypA;COG1217;Predicted membrane GTPase TypA/BipA involved in stress response;TypA;HELO_RS00625;T;typA; GTP-binding protein TypA;;typA;GTP-binding protein TypA;-0.3636651727445912;-0.014235133743454753;0.13994035939956895;-0.7837262358296986;-0.4200610630851074
HELO_1122;66.92308627278744;27.31764156670874;42.91209557159916;56.32162097915091;41.53739638928365;48.48732461251499;4.4634409208689245;1.727060447805853;5.945119728834211;2.5247787948984026;2.280507552450592;2.84253610033742;HELO_1122;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS00630;K;;typA;;HELO_1122;LysR family transcription regulator;1.2622008975656387;-0.17244066487154885;-0.21832731708320985;0.4568429639843288;-0.8053579335813099
HELO_1123;10.912978422767237;8.206070661095465;5.525619044574086;5.46630721607054;5.616131771457515;6.9897615922234175;0.29669902891190786;0.5037781859903901;0.7155460591046475;0.8886425295341924;0.2799813969100758;0.9265620762525743;HELO_1123;hydroxylase domain protein;;;;;;;;;HELO_1123;hydroxylase domain protein;0.3718767325281762;-0.2920376873772943;-0.2721644864791317;0.576309793535625;0.20443306100744874
HELO_1124;4.801176701247817;5.925211228996635;5.669945249225537;5.6586874224492085;5.852692710426559;6.784405788082175;0.3817011928564625;0.45866689424321166;0.4749573735337859;0.2695667858246679;0.3920837276056302;0.5840644538095572;HELO_1124;peptidase M24 family protein;COG0006;Xaa-Pro aminopeptidase;PepP;HELO_RS00640;E;;;3.4.11.9;HELO_1124;peptidase M24 family protein;-0.255512512287412;-0.2229119983821679;-0.18391592248259858;-0.4242413535251899;-0.16872884123777787
HELO_1125;36.43183138112104;36.120928011879364;43.348825384339314;38.14954388395146;46.82356009134767;40.1049409238218;4.791494907003189;3.441853126210988;7.524053972765788;3.818125120131499;5.29062955865742;4.793287156318087;HELO_1125;ABC-type transport system periplasmic substrate-binding protein;COG2113;ABC-type proline/glycine betaine transport system, periplasmic component;ProX;HELO_RS00645;E;;;;HELO_1125;ABC-type transport system periplasmic substrate-binding protein;0.012032857076036407;0.1095840739176186;0.21840971131741327;-0.13504618520388423;-0.14707904227992064
HELO_1126;1180.9444437002212;1521.6223456234547;1591.1917347362303;1561.4307485114302;1700.8797046381508;1570.333547866754;100.54225640713604;132.2271417555568;142.79110047160592;216.2419843849848;138.0427712685082;100.06064269824853;glnA;glutamine synthetase;COG0174;Glutamine synthetase;GlnA;HELO_RS00650;E;glnA; glutamine synthetase;6.3.1.2;glnA;glutamine synthetase;-0.36539593165265316;0.019024623567538868;0.11513961059104894;-0.41082723038952373;-0.04543129873687057
HELO_1127;24.826255978372938;25.22798979539996;36.166365942968326;37.73353122442822;26.325230413513278;29.047701582435437;0.6787418165714677;1.9451827627047253;3.4078373594737994;0.520650616012783;1.3039553543207674;2.053892092724041;HELO_1127;DUF4124 domain protein;;;;;;;;;HELO_1127;DUF4124 domain protein;-0.02226872694896631;0.30674299099424207;-0.13702097897487597;-0.2184161283943311;-0.1961474014453648
HELO_1128;40.3967300053055;55.36546728455633;47.269109704634054;59.4559236151587;44.731031198002164;46.68321504246996;2.1855760369699735;1.5379763899709682;1.5567275896725523;6.071562268291409;3.635847084000958;2.0032572487147813;ntrB;PAS domain protein / sensor histidine kinase NtrB;COG3852;Signal transduction histidine kinase NtrB, nitrogen specific;NtrB;HELO_RS00660;T;ntrB; PAS domain protein / sensor histidine kinase NtrB;2.7.13.3;ntrB;PAS domain protein / sensor histidine kinase NtrB;-0.44529474420137216;0.017618704521596307;-0.06030806171857783;-0.20396470143462508;0.24133004276674708
HELO_1129;49.65810067074969;70.71241415325714;71.37337343343951;89.56498830315905;73.56546574484646;71.8267484764372;2.558600368369251;9.12940527179274;5.322045705739943;9.10194810463267;3.6234066054060747;4.984278580731917;ntrC;response regulator/sigma-54-interact/HTH domain transcription regulator NtrC;COG2204;DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains;AtoC;HELO_RS00665;T;ntrC; response regulator/sigma-54-interact/HTH domain transcription regulator NtrC;;ntrC;response regulator/sigma-54-interact/HTH domain transcription regulator NtrC;-0.5014298988773138;-0.009009414637626278;0.03403918124485017;-0.523675447076795;-0.022245548199481213
HELO_1130;32.93626781014278;33.25820648480071;35.29803229238539;47.50074737752888;43.58656296004591;33.375537120100695;2.077946987964222;1.6595623733829645;1.9272700490400083;2.4297536973350176;2.1828134774580144;1.792021772810395;HELO_1130;uncharacterized protein;;;;;;;;;HELO_1130;uncharacterized protein;-0.013621713040143923;0.07850908628032016;0.3752267351399743;-0.01855434476611162;-0.0049326317259676955
HELO_1131;109.89353786370027;123.63589162004251;150.50893658157838;127.16634867211444;180.36532687030854;159.92068258864717;8.856630522014413;4.06194670255851;14.098499010278202;2.743958036265071;9.160063381018865;17.332080369571106;HELO_1131;peptidase M24 family protein;COG0006;Xaa-Pro aminopeptidase;PepP;HELO_RS00675;E;;;3.4.11.9;HELO_1131;peptidase M24 family protein;-0.16854428636020913;-0.08694687074363472;0.17254890745368723;-0.5371744653734041;-0.36863017901319495
HELO_1132;30.93263358710526;36.92256853821318;18.915029706755035;19.116877481525375;12.37608798421572;20.355059475765454;0.9181394178142002;1.0048798851495626;2.1444940430188053;2.064347209594885;0.3598634099300911;0.7184620342951097;HELO_1132;major facilitator superfamily transport protein;COG3104;Dipeptide/tripeptide permease;PTR2;HELO_RS00680;E;;;;HELO_1132;major facilitator superfamily transport protein;-0.24802514138319776;-0.10072028428532143;-0.6749216738088539;0.5804536254984463;0.828478766881644
HELO_1133;264.7685002791114;114.15427387060738;612.50444247809;614.9729184662918;1005.8637795327937;613.0538881202087;49.69980221969743;11.187226659517247;16.777057061041695;38.09049014637639;75.71466874646369;40.55031569905132;hmgL2;hydroxymethylglutaryl-CoA lyase;COG0119;Isopropylmalate/homocitrate/citramalate synthases;LeuA;HELO_RS00685;E;hmgL2; hydroxymethylglutaryl-CoA lyase;4.1.3.4;hmgL2;hydroxymethylglutaryl-CoA lyase;1.2066021652348287;-0.0012914784353608155;0.713431337414363;-1.20819514715342;-2.4147973123882487
HELO_1134;130.6048025937213;59.417300469530154;267.8080415024929;285.35595945517684;540.2590662162503;280.4721565335172;16.664520878748505;4.307350313266305;16.181164132279832;17.89485079769592;1.0138105831340745;18.940868414670792;HELO_1134;CoA transferase family protein;COG1804;Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases;CaiB;HELO_RS00690;I;;hmgL2;2.8.3.19;HELO_1134;CoA transferase family protein;1.1231785086796027;-0.06641591916181255;0.9433270687857043;-1.096780079093742;-2.2199585877733448
HELO_1135;107.601908600915;72.20177872865573;357.7544200359577;394.0176856830289;809.1197723254272;336.90860715530397;3.4091518855738094;2.6078335093692284;7.994265481895094;18.88522530858159;7.530455355558482;18.223689682883712;HELO_1135;TTT family transporter substrate-binding protein;COG3181;Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC;TctC;HELO_RS00695;C;;;;HELO_1135;TTT family transporter substrate-binding protein;0.5690988476314143;0.08636350755796052;1.2615021202404613;-1.6375836413734888;-2.206682489004903
HELO_1136;85.3488318926358;49.698875248289305;122.20945977309675;120.86467206847942;282.9959775916332;124.72709163661261;11.833641840313545;0.40081512774894434;10.078826684158729;7.914225756059401;24.656239266234426;5.125798131814756;HELO_1136;TTT family transporter small transmembrane protein;;;;;;;;;HELO_1136;TTT family transporter small transmembrane protein;0.7682229199608495;-0.029182527265986025;1.1755749413459995;-0.5420469882098917;-1.3102699081707412
HELO_1137;30.364083056601448;25.70778590364529;78.08291134406055;82.40912985654178;167.6818528918799;75.39765793101643;2.7415217285944946;2.3364570241375593;4.630436933334736;2.639819934993722;7.451911915546046;6.651268021292286;HELO_1137;TTT family transporter large transmembrane protein;COG3333;TctA family transporter;;HELO_RS00705;R;;;;HELO_1137;TTT family transporter large transmembrane protein;0.23185300502968698;0.0498375719031543;1.1427044577825471;-1.2844150258452158;-1.5162680308749028
HELO_1138;83.5838222441448;64.42013237640835;101.55822522020257;120.95484950798924;130.0426168826322;99.59303780174383;1.277939926794053;0.3253150071213793;4.809144910235649;5.155848241896368;0.9398012786707046;0.47301461749865503;HELO_1138;deoxynucleosidetriphosphate triphosphohydrolase;COG0232;dGTP triphosphohydrolase;Dgt;HELO_RS00710;F;;;3.1.5.1;HELO_1138;deoxynucleosidetriphosphate triphosphohydrolase;0.370647076853853;0.02791274384633713;0.38150561511144154;-0.2500767968082611;-0.6207238736621141
HELO_1139;546.8180919772659;31.23534231477368;64.88295578775303;74.3025048654776;63.80490417089786;58.870268420635085;11.822677276135929;0.5203626980760544;6.611015398157791;6.474499245874686;2.9132158516353948;4.222016399621316;HELO_1139;RimK family protein;COG0189;Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily;LysX;HELO_RS00715;JEHQ;;;6.3.2.-;HELO_1139;RimK family protein;4.086981703580859;0.13806554351861777;0.11426325612652466;3.1937852690785693;-0.8931964345022898
HELO_1140;99.30482162220459;58.21223731158772;93.71982835765967;95.70512887537517;91.65219392408443;80.28569917676946;2.9152978060686787;3.7167477106364446;1.4508746151229908;8.952630347368421;0.8171163878039336;3.7231262556087907;rna;ribonuclease I;COG3719;Ribonuclease I;RnaI;HELO_RS00720;J;rna; ribonuclease I;4.6.1.21;rna;ribonuclease I;0.7604236859481981;0.22066490945202055;0.18882358123063803;0.3033174952139248;-0.4571061907342733
HELO_1141;92.97113545877791;31.148252652277453;59.105760485181;62.55281978093288;51.2487328328499;53.532190009618354;4.399798665915222;1.5428342010903155;3.775640152092698;4.52952466843636;5.53140577609287;9.765112946732156;HELO_1141;NERD domain protein;;;;;;;;;HELO_1141;NERD domain protein;1.5474773558269295;0.14039516906286398;-0.061712046645622465;0.7851095858175992;-0.7623677700093303
HELO_1142;94.2056747814508;40.27919308475381;84.26742411075854;90.22484542525869;82.51997577191047;80.6460022269747;2.9561812021905363;3.2939160881854863;12.85614275514719;13.285690031807514;6.61064706601726;4.09028141036076;npdA2;NAD-dependent deacetylase;COG0846;NAD-dependent protein deacetylase, SIR2 family;SIR2;HELO_RS00730;O;npdA2; NAD-dependent deacetylase;;npdA2;NAD-dependent deacetylase;1.205632799051048;0.06261242776373344;0.0327390470317761;0.22166532228089064;-0.9839674767701574
HELO_1143;72.45182232311392;60.851137087122105;116.0167801520646;106.5878960285916;140.8168907536348;107.81579274111552;10.200588675090136;3.718013718740926;14.429318154965722;11.349086702044588;17.160321906653735;4.812599865963775;yciH;SUI1 family protein YciH;COG0023;Translation initiation factor 1 (eIF-1/SUI1);SUI1;HELO_RS00735;J;yciH; SUI1 family protein YciH;;yciH;SUI1 family protein YciH;0.24799816584349;0.10482747228360623;0.3821414173118942;-0.5670177648842234;-0.8150159307277134
HELO_1144;9.914013988170199;11.468646027880714;7.911619068772658;7.0879839543803085;5.9687451543324705;7.554325733790885;0.4397711637547515;0.683619370328601;0.21333100928031556;0.8231867159028252;1.507142205260119;1.0041317436677044;HELO_1144;flavin-dependent dehydrogenase;COG1304;FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase;LldD;HELO_RS00740;CIR;;yciH;1.1.99.31;HELO_1144;flavin-dependent dehydrogenase;-0.19212301332064552;0.0590334217686066;-0.29575524681598964;0.3514557492025956;0.5435787625232411
HELO_1145;16.6213815258607;13.092949903088085;23.236028411116134;20.33823864291165;18.479616787146742;21.92682080746968;1.8420197590924372;0.7073644489877703;3.8528487508427034;2.4718459219199413;1.4700358702544407;2.4853220297742364;rspR;GntR family transcription regulator RspR;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS00745;K;rspR; GntR family transcription regulator RspR;;rspR;GntR family transcription regulator RspR;0.32235341197969314;0.08011698725025429;-0.2350710183787852;-0.3797092778877653;-0.7020626898674585
HELO_1146;23.442208222714928;20.079473986324846;22.486318262476797;25.833507604003284;24.208391893876737;22.75959296781494;1.8604393456194028;1.159485357662224;0.8292995413672006;3.3228954416040786;0.8848358543335212;2.034313584309911;rspA;mannonate/gluconate dehydratase;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS00750;MR;rspA; mannonate/gluconate dehydratase;4.2.1.8;rspA;mannonate/gluconate dehydratase;0.213535764168304;-0.016689548309090974;0.08539396687983736;0.0408645096803717;-0.1726712544879323
HELO_1147;30.002325707950718;25.64726606285564;40.06045228943222;38.70016732842733;42.069413439004975;43.66230669193817;1.956292782560891;0.6680280654813873;0.46985121765760113;1.1849949361225323;1.7039878517233018;2.910196444709218;rspB;L-gulonate dehydrogenase;COG1063;Threonine dehydrogenase or related Zn-dependent dehydrogenase;Tdh;HELO_RS00755;ER;rspB; L-gulonate dehydrogenase;1.1.1.380;rspB;L-gulonate dehydrogenase;0.21838892253168307;-0.12130824540953267;-0.05239408883496033;-0.5266813180151377;-0.7450702405468208
HELO_1148;26.01668535264685;31.474287301970588;91.61685565842997;89.21663087528644;113.29390090763731;95.49398882931392;0.7022144440466116;0.4439457015542442;8.192189157291894;7.151122268914068;13.417099726381224;4.227624872656063;HELO_1148;TRAP transporter substrate-binding protein (probable substrate D-mannonate/L-gulonate);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS00760;G;;rspB;;HELO_1148;TRAP transporter substrate-binding protein (probable substrate D-mannonate/L-gulonate);-0.26544718100961084;-0.059164292944464236;0.2442374422870115;-1.836588388475282;-1.5711412074656712
HELO_1149;22.726569313803992;36.025909327714736;31.11194761770515;30.44537581569504;36.76727396036572;34.69151050790841;0.5877422578170326;1.9066339524174616;1.8148458930842408;2.000991574533137;3.972681403498319;2.72362164154024;HELO_1149;TRAP transporter small transmembrane protein (probable substrate D-mannonate/L-gulonate);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS00765;G;;;;HELO_1149;TRAP transporter small transmembrane protein (probable substrate D-mannonate/L-gulonate);-0.642031654830526;-0.152470790845471;0.08155569461344303;-0.5890774466848425;0.05295420814568352
HELO_1150;14.466271517533487;16.331028928483295;19.956323523861567;19.98376734960334;25.61773608460838;24.66892263605784;0.33694971009963626;0.38704637113686474;2.386739840760318;2.708453912745212;2.7624768432159144;2.367811809728016;HELO_1150;TRAP transporter large transmembrane protein (probable substrate D-mannonate/L-gulonate);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS00770;G;;;;HELO_1150;TRAP transporter large transmembrane protein (probable substrate D-mannonate/L-gulonate);-0.16423186306138104;-0.2926371054395007;0.05236512601780241;-0.7308972995067609;-0.5666654364453798
HELO_1151;20.225878447820417;17.631195108863007;29.816214308320042;32.51767924891234;34.91327498891903;29.52908993904423;0.7759830304895711;1.6661988219843422;2.035348271281442;2.396621642325398;1.937049266549297;1.8517601368915686;rspD;fructuronate reductase;COG0246;Mannitol-1-phosphate/altronate dehydrogenases;MtlD;HELO_RS00775;G;rspD; fructuronate reductase;1.1.1.57;rspD;fructuronate reductase;0.1881040421952873;0.013505057432621648;0.23433263669062665;-0.5243603220196711;-0.7124643642149584
HELO_1152;27.796023028654016;19.92508460551199;40.74091922082684;38.60448971247934;48.476514473510896;43.79567936706962;1.3807914601066633;0.7429779661125383;2.627616911635062;0.9299062354797866;4.735484617870029;1.741958757045371;uxuA;mannonate dehydratase;COG1312;D-mannonate dehydratase;UxuA;HELO_RS00780;G;uxuA; mannonate dehydratase;4.2.1.8;uxuA;mannonate dehydratase;0.4606361212122154;-0.10189721621158743;0.14338428059916453;-0.6374900109813533;-1.0981261321935687
HELO_1153;20.30888107820977;9.636433400915466;24.810617381109324;7.567660449047345;10.889495519807673;46.24966715562499;1.77652482535823;0.7818440277773298;18.760096310927214;0.5115152362591247;1.654133776549469;59.67353105662839;HELO_1153;TonB-dependent receptor;COG4774;Outer membrane receptor for monomeric catechols;Fiu;HELO_RS00785;P;;uxuA;;HELO_1153;TonB-dependent receptor;1.002440370952745;-0.8723395158697569;-1.9906166647325905;-1.148849326780188;-2.151289697732933
HELO_1154;33.24364211288988;5.346901424025763;24.044286067642542;11.666828927932288;12.920790507027315;25.01572113801223;0.6709598587650909;0.6190723281817214;13.879684941285223;1.5459525866600317;2.3879426982545047;21.283639387652368;HELO_1154;ViuB domain protein;COG2375;NADPH-dependent ferric siderophore reductase, contains FAD-binding and SIP domains;ViuB;HELO_RS00790;P;;;;HELO_1154;ViuB domain protein;2.431711812322086;-0.05490221282097352;-0.9021425598906667;0.39645245483215863;-2.0352593574899274
HELO_1155;19.127946888649593;35.64810317946459;37.006662144537096;32.64369364771022;37.664817646981675;39.52216253981623;0.640146236142287;2.292105899120108;2.0497788207941348;2.763884751293412;1.6844700114851063;3.5535204572899075;xylX1;2-keto-3-deoxyxylonate dehydratase;COG3970;Fumarylacetoacetate (FAA) hydrolase family protein;;HELO_RS00795;R;xylX1; 2-keto-3-deoxyxylonate dehydratase;;xylX1;2-keto-3-deoxyxylonate dehydratase;-0.8645385092391278;-0.09245883917649156;-0.06768975932017174;-1.0095111477564735;-0.14497263851734576
HELO_1156;73.56834457998411;91.51970531996932;91.06700771300056;101.05883439034464;87.53619448213836;90.9758806269475;1.8837819589074065;3.7440254264547415;5.31464998967106;1.3727215477599286;4.67547112704367;2.5681919292182864;HELO_1156;ROK family transcription regulator;COG1940;Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain;NagC;HELO_RS00800;KG;;xylX1;;HELO_1156;ROK family transcription regulator;-0.31119735692711714;0.0014286735778714643;-0.054988220457370396;-0.3026922704126518;0.008505086514465354
HELO_1157;3.099555823305217;4.135251856876224;6.885085631676218;4.856965249269094;4.550444393755849;6.520026352930852;0.2801382045788966;0.4710770625317843;1.3746360886429523;1.2766667945812744;0.3035560210963055;0.48866809466099215;galD;D-xylose/galactose 1-dehydrogenase;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS00805;I;galD; D-xylose/galactose 1-dehydrogenase;1.1.1.175;galD;D-xylose/galactose 1-dehydrogenase;-0.32496742904867215;0.06838870505987593;-0.4381344328480763;-0.8752701118719188;-0.5503026828232467
HELO_1158;4.0202726641034205;7.723832614189026;11.64393298872863;11.668936421628244;8.60524485549554;11.761818703209528;0.41214282527658497;0.9171774258434874;0.6279912453503793;0.8700769862329312;0.3224886092491323;2.3372021669096013;HELO_1158;ABC-type transport system periplasmic substrate-binding protein;COG1653;ABC-type glycerol-3-phosphate transport system, periplasmic component;UgpB;HELO_RS00810;G;;galD;;HELO_1158;ABC-type transport system periplasmic substrate-binding protein;-0.7971963661493131;-0.013388649810443187;-0.40993964763861257;-1.3459963161340962;-0.5487999499847831
HELO_1159;3.834659740933041;9.416201346173635;10.25672037080416;8.769754978183647;8.343666115346846;12.565458896374977;1.2953572163266676;1.0259457428232346;2.302118356453451;1.5128292586025611;2.0087684622608912;1.504638543880025;HELO_1159;ABC-type transport system permease protein;COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS00815;G;;;;HELO_1159;ABC-type transport system permease protein;-1.1073429785301356;-0.26915129083789413;-0.537877225079626;-1.4884515895724069;-0.38110861104227123
HELO_1160;4.677762169390818;7.214225887099782;7.195557965610824;6.785133863707853;4.8587441463263366;8.533850262092729;0.9887918484379309;0.8028681217338272;0.6562797457350527;2.1525981034233124;1.5306429061324487;2.202355460139522;HELO_1160;ABC-type transport system permease protein;COG0395;ABC-type glycerol-3-phosphate transport system, permease component;UgpE;HELO_RS00820;G;;;;HELO_1160;ABC-type transport system permease protein;-0.532802202664731;-0.2182167932664405;-0.7024675184713733;-0.7477365481407952;-0.21493434547606416
HELO_1161;5.6237000717467085;5.923862237623027;8.263566847342616;7.063081879777954;6.949014749844646;9.264342291988442;0.6360003845735914;0.06921713859918925;0.7711693901514817;0.46879617882331276;0.6076642623197231;0.34800058928661276;xynB;beta-xylosidase;COG3507;Beta-xylosidase;XynB2;HELO_RS00825;G;xynB; beta-xylosidase;3.2.1.37;xynB;beta-xylosidase;-0.06393967250790578;-0.14800148544974068;-0.36879322684759686;-0.631931934225153;-0.5679922617172473
HELO_1162;5.10787073422756;6.45135021199228;9.656673656556539;8.372052143133358;9.396760737555159;10.352818610045786;0.2808076258285716;0.9682950325073059;0.8732478194485156;1.680806668893528;0.8407665604761717;1.7862653272767108;HELO_1162;ABC-type transport system ATP-binding protein;COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS00830;G;;xynB;7.5.2.-;HELO_1162;ABC-type transport system ATP-binding protein;-0.2868323413522562;-0.09129333601619827;-0.12691642000842007;-0.8943090910445246;-0.6074767496922684
HELO_1163;5.389907238901281;5.91810019063401;9.982140458161487;8.615583546668654;7.032803669058803;10.998527952223128;0.8007620697140977;0.8375824247575424;1.2116382887181971;1.1616157888091398;0.7138629779750688;2.3961707820190603;lamB2;maltoporin;COG4580;Maltoporin (phage lambda and maltose receptor);LamB;HELO_RS00835;G;lamB2; maltoporin;;lamB2;maltoporin;-0.11458091954839977;-0.1276981505085999;-0.5788818977067827;-0.9089905255418844;-0.7944096059934846
HELO_1164;5.97747793793411;3.0501707969578695;5.804630188161941;6.128427061493949;4.801104849038134;5.185917811719357;0.542576971066606;0.2848312973605321;1.4007218155197907;0.45618400320413866;0.5489470723678742;0.8288404718768217;HELO_1164;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS00840;G;;lamB2;;HELO_1164;major facilitator superfamily transport protein;0.7847229094684334;0.1375290921843435;-0.09265997060349473;0.17371799224500206;-0.6110049172234313
HELO_1165;9.517271752291878;4.155459056189937;8.276564724705986;10.272996349897598;7.193024888302102;7.706410384975434;0.7800726228366053;0.2190962604300291;0.38746178999012776;0.4127889655962224;0.7805595238524458;1.7375977018238893;HELO_1165;homolog to xylono-1%2C4-lactonase;COG3386;Sugar lactone lactonase YvrE;YvrE;HELO_RS00845;G;;;;HELO_1165;homolog to xylono-1%2C4-lactonase;1.028587708879087;0.09151262433021756;-0.0876818271708526;0.27261057917032083;-0.7559771297087661
HELO_1166;178.1720633313205;228.82131324681396;319.2235314249761;249.93127502503307;301.9507727782546;324.07699840904365;12.90364176588213;9.143639078740543;8.728963578507814;10.90446006946616;11.383635576012031;27.997939337802066;HELO_1166;HAD superfamily hydrolase;COG0637;Beta-phosphoglucomutase, HAD superfamily;YcjU;HELO_RS00850;G;;;;HELO_1166;HAD superfamily hydrolase;-0.359166888702827;-0.0217021510558002;-0.10169809269342522;-0.8594357697169199;-0.500268881014093
HELO_1167;12.581549762931493;35.522057950744305;26.500607144516675;23.104904191605147;33.80163587467993;33.50634668945151;0.9764071604017427;1.244201650941297;1.1547168973835558;1.9599723008506302;1.8044252413146653;3.4393115289139784;HELO_1167;TRAP transporter large transmembrane protein (probable substrate D-mannuronate);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS00855;G;;;;HELO_1167;TRAP transporter large transmembrane protein (probable substrate D-mannuronate);-1.4271199488595827;-0.3273982684844867;0.012293383968387417;-1.3452136266027543;0.08190632225682837
HELO_1168;16.86311098967627;59.25822207836959;37.818162371695905;31.734657784738474;46.80245127437873;46.101033680229925;0.9264954022754159;1.5744640473670761;0.5639289051407915;5.755466307526713;3.896325752588791;2.8005031674995924;HELO_1168;TRAP transporter small transmembrane protein (probable substrate D-mannuronate);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS00860;G;;;;HELO_1168;TRAP transporter small transmembrane protein (probable substrate D-mannuronate);-1.7541747486840906;-0.27902689824146343;0.021325878838774237;-1.3987753635074807;0.35539938517660996
HELO_1169;28.074220259130495;87.28530553321127;108.30845513595284;94.45181389222614;122.50154362880147;126.54704868038618;1.9409970494065065;1.9902534775996463;0.20428506676632446;7.771247090001129;4.406423313808052;13.398188819879767;HELO_1169;TRAP transporter substrate-binding protein (probable substrate D-mannuronate);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS00865;G;;;;HELO_1169;TRAP transporter substrate-binding protein (probable substrate D-mannuronate);-1.6024328308241502;-0.22262451724749077;-0.04650044274095855;-2.1332171109868288;-0.5307842801626785
HELO_1170;39.76522693279473;98.9847135077993;70.46204322891067;54.019603790830026;78.24228587164417;75.52720122136492;0.23041371105199582;4.718358305384366;4.3192712786007545;4.429999005035146;3.706486741794492;4.493793779227642;ghrB;probable 2-ketogluconate reductase;COG1052;Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase;LdhA;HELO_RS00870;CHR;ghrB; probable 2-ketogluconate reductase;1.1.1.43;ghrB;probable 2-ketogluconate reductase;-1.2943684942974265;-0.09879547412601575;0.05029785979850665;-0.9086335916292327;0.38573490266819377
HELO_1171;35.36840184314011;74.18982075932956;54.97959077394402;36.433425022851075;45.107606636388056;54.37531009415551;3.6498618885582474;2.3339964735516734;0.587005447982013;2.4460373016814247;1.074099991410658;1.6621984072180507;kguK;probable 2-dehydro-3-deoxygluconokinase;COG0524;Sugar or nucleoside kinase, ribokinase family;RbsK;HELO_RS00875;G;kguK; probable 2-dehydro-3-deoxygluconokinase;2.7.1.13;kguK;probable 2-dehydro-3-deoxygluconokinase;-1.047851832210048;0.01565806787067725;-0.26423809261761644;-0.6065573425471689;0.4412944896628792
HELO_1172;30.547683048165357;47.27455565784228;30.817218419531446;22.791975621817425;24.238903637350656;32.42620754669195;2.958504742962382;2.2737683817770984;3.7411965488628587;5.39529818766134;2.0358196923068776;1.6241878185496623;ptxS;LacI family transcription regulator PtxS;COG1609;DNA-binding transcriptional regulator, LacI/PurR family;PurR;HELO_RS00880;K;ptxS; LacI family transcription regulator PtxS;;ptxS;LacI family transcription regulator PtxS;-0.6137289265208148;-0.07117196432013095;-0.40533043781002664;-0.08344562623572127;0.5302833002850935
HELO_1173;21.081198343603543;23.1670953070238;35.521732360956165;51.894397987225375;49.374690443332355;32.600197033923585;1.634181458346926;1.007672987746103;5.084656990278916;2.5172586448561822;3.998878054843616;2.2790445381604783;HELO_1173;HTH domain protein;COG2771;DNA-binding transcriptional regulator, CsgD family;CsgD;HELO_RS00885;K;;ptxS;;HELO_1173;HTH domain protein;-0.13022561393145615;0.12028550621706913;0.5842293750924368;-0.6056512239916945;-0.4754256100602383
HELO_1174;8.828490256304484;6.091782345426842;10.00251177887224;12.496229643835827;14.469932675841335;9.307426295979981;1.3321214304859295;0.7695386292952034;1.3387137740890962;0.43747904973036866;1.6679274332407454;1.7293299945846536;HELO_1174;pyridoxal phosphate-dependent aminotransferase;COG0161;Adenosylmethionine-8-amino-7-oxononanoate aminotransferase;BioA;HELO_RS00890;H;;;;HELO_1174;pyridoxal phosphate-dependent aminotransferase;0.4708215637451585;0.0941487710634985;0.5857827731195271;-0.06864241728266052;-0.539463981027819
HELO_1175;10.469909456142334;6.282011866647889;12.878964182394;13.717104484479892;15.882284691017764;12.655089956448338;2.1127009578867355;0.6293748221782274;1.11848063789591;1.074353196133665;0.9654011312171702;1.277073854693117;HELO_1175;APC family transport protein;COG0531;Serine transporter YbeC, amino acid:H+ symporter family;PotE;HELO_RS00895;E;;;;HELO_1175;APC family transport protein;0.6554450058253645;0.02346108216914633;0.3060713398915844;-0.25158481554776246;-0.9070298213731269
HELO_1176;113.07596547144527;13.433681151705997;36.32072272255442;34.86579181902064;31.68908830748723;32.28620441649104;6.82755883118649;0.8965920637810825;3.6452742907786617;3.1737921193471337;10.81028183394774;7.18876636183614;HELO_1176;HAD superfamily hydrolase;COG0637;Beta-phosphoglucomutase, HAD superfamily;YcjU;HELO_RS00900;G;;;;HELO_1176;HAD superfamily hydrolase;2.9824836685719633;0.16505255333275493;-0.026115230004734258;1.7769985876612546;-1.2054850809107087
HELO_1177;12.010917582506181;12.12458216322392;11.866066912813658;10.174975963780454;12.509229494395868;10.726184392501553;0.38473160517524546;0.9267394650206776;1.0305982011979555;1.4239299451933791;1.1157485819975714;1.1246094718269968;HELO_1177;HTH/PAS domain protein;;;;;;;;;HELO_1177;HTH/PAS domain protein;-0.012548783256962626;0.13383744868004355;0.2042117439930733;0.1499890621403095;0.16253784539727212
HELO_1178;9.193012992411239;6.882120925580854;9.299444419888578;9.598433873979301;10.448902707869129;7.92105650898196;0.3028372396568362;0.5240718969395785;0.12868837997956178;0.6963843351116719;0.5638923951243408;1.0453657276932236;HELO_1178;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS00910;G;;;;HELO_1178;major facilitator superfamily transport protein;0.37092477815637004;0.20728003475244838;0.35992285151244374;0.1922940845394976;-0.17863069361687245
HELO_1179;32.717491057181284;12.964608448428239;17.986768868759135;20.031891704222698;16.348789107824476;17.818222886626554;2.9357056341509273;1.2549659867207996;1.2663501207970727;2.955972309208447;0.8360057946258775;1.7876686543688396;HELO_1179;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS00915;J;;;;HELO_1179;GNAT family acetyltransferase;1.2717220656216788;0.01286401886985633;-0.11729542184532349;0.8413667958140891;-0.43035526980758965
HELO_1180;565.4810721377486;658.3748295183501;802.5082793709722;538.8677236615769;751.3806439600917;840.1561032195591;21.713320240545645;6.6069756026784034;39.1040315453455;11.186432745917228;32.72842881179929;54.77448497587388;fbaA;fructose-bisphosphate aldolase%2C class II;COG0191;Fructose/tagatose bisphosphate aldolase;Fba;HELO_RS00920;G;fbaA; fructose-bisphosphate aldolase, class II;4.1.2.13;fbaA;fructose-bisphosphate aldolase%2C class II;-0.2190710636929758;-0.06606067364837642;-0.1609108291945791;-0.5703458111891031;-0.3512747474961273
HELO_1181;423.5091879673624;552.6068719674652;539.6075167957466;426.2424805105749;590.135494859535;559.9507402024742;19.49165057375085;27.511067215954164;34.82282852474284;20.02212278577663;7.586884097976508;44.61868116099069;pgk;phosphoglycerate kinase;COG0126;3-phosphoglycerate kinase;Pgk;HELO_RS00925;G;pgk; phosphoglycerate kinase;2.7.2.3;pgk;phosphoglycerate kinase;-0.3830660719419896;-0.05329251461941631;0.07561476376035259;-0.4020783069317062;-0.019012234989716603
HELO_1182;250.01014811401365;276.9643959465014;283.6979651374215;299.8362375972026;205.69960660019228;274.6940533597826;16.685198830287867;8.345412192882131;12.87014764241295;17.381422343897036;9.656271889417171;16.831461441485335;epd;D-erythrose-4-phosphate dehydrogenase;COG0057;Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase;GapA;HELO_RS00930;G;epd; D-erythrose-4-phosphate dehydrogenase;1.2.1.72;epd;D-erythrose-4-phosphate dehydrogenase;-0.1471544098669053;0.04636403236294839;-0.41553250620785764;-0.13532245695789236;0.011831952909012955
HELO_1183;447.01748155360764;217.95257920342098;696.4832074228378;538.7883033101275;589.6455039792064;660.1002949290643;10.220341347257563;3.4948381431645474;36.37909261824802;3.5570553834065466;149.46700862579067;156.5170811132215;fbaB;fructose-bisphosphate aldolase%2C class I;COG1830;Fructose-bisphosphate aldolase class Ia, DhnA family;FbaB;HELO_RS00935;G;fbaB; fructose-bisphosphate aldolase, class I;4.1.2.13;fbaB;fructose-bisphosphate aldolase%2C class I;1.0329365826003043;0.07728932479370698;-0.16257665073334948;-0.56131413124284;-1.5942507138431443
HELO_1184;9.5029143416957;10.860993614536097;99.41298833758896;80.04186888094166;130.3725986343891;105.88664032496264;0.93413898664435;1.0564003845646084;8.526273393667843;8.890572049619594;9.80968189106709;12.388409381179299;tktA2;transketolase;COG0021;Transketolase;TktA;HELO_RS00940;G;tktA2; transketolase;2.2.1.1;tktA2;transketolase;-0.17543517032988198;-0.09013565025840098;0.2975828503052034;-3.347219936419995;-3.171784766090113
HELO_1185;0.8860823634060367;0.6441980524875072;4.081844610399778;3.0990750252302153;10.044730563000781;4.09469944013309;0.1494898114243903;0.11303220911596823;0.5320542429349081;0.20143614676264812;1.0139331404068856;0.9443910341813897;talA1;transaldolase;COG0176;Transaldolase/fructose-6-phosphate aldolase;TalA;HELO_RS00945;G;talA1; transaldolase;2.2.1.2;talA1;transaldolase;0.1980085886418157;-0.0036447754521784503;1.1162892817070231;-1.433604359157167;-1.6316129477989825
HELO_1186;20.253584521048854;11.640729687914236;38.650000667533284;32.947065962801446;82.43004121560922;37.21825962563207;0.8694633715795845;1.0708259103810134;3.9914322893870793;1.088876473426604;5.901920431840883;1.6712440375350373;HELO_1186;DhaL domain protein;COG2376;Dihydroxyacetone kinase;DAK1;HELO_RS00950;G;;talA1;2.7.1.121;HELO_1186;DhaL domain protein;0.749626433655838;0.05305880752366754;1.1263048754232088;-0.8465559033437993;-1.5961823369996373
HELO_1187;14.81817209399499;7.034421370917047;41.00552593056987;31.05816014386176;81.7471990634915;39.389988399222645;0.39945204405006846;0.303886222466945;3.3087144450856854;2.551811231218079;9.62713075092515;1.507512538375294;HELO_1187;DhaK domain protein;COG2376;Dihydroxyacetone kinase;DAK1;HELO_RS00955;G;;;2.7.1.121;HELO_1187;DhaK domain protein;0.9773168637876917;0.056581398796692994;1.034712746827255;-1.3524148362407349;-2.3297317000284266
HELO_1188;7.491586903054395;4.766593401807167;9.50998047493856;11.228288263855793;13.798036299330477;8.802638807841497;0.8086175557420245;0.4019052584678136;0.8967914105768303;1.881116132739702;2.949866426318349;0.8368690295928553;rpiB;ribose 5-phosphate isomerase B;COG0698;Ribose 5-phosphate isomerase RpiB;RpiB;HELO_RS00960;G;rpiB; ribose 5-phosphate isomerase B;5.3.1.6;rpiB;ribose 5-phosphate isomerase B;0.5583148863919245;0.10051791819061329;0.594163671876168;-0.20713597678924556;-0.7654508631811701
HELO_1189;89.51575576484878;50.805593166229976;95.31111488906198;120.73872768699043;122.58198732984238;95.83971534306288;5.390148292416775;1.601723217416806;6.552727607839822;2.7423315209386057;11.035659553390822;4.036620949218689;HELO_1189;LsrR family transcription regulator;COG2390;DNA-binding transcriptional regulator LsrR, DeoR family;DeoR;HELO_RS00965;K;;rpiB;;HELO_1189;LsrR family transcription regulator;0.8050610727907381;-0.007896535123195214;0.35179773510692947;-0.09742989959629522;-0.9024909723870334
HELO_1190;32.499100984811996;21.993464021319127;78.7663592805899;71.78421338127849;116.32004386390791;78.07485119825728;1.1668959628830222;1.8612059082974624;3.632574404282538;1.2879221634204923;2.305282075773705;6.789381953609126;HELO_1190;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG1063;Threonine dehydrogenase or related Zn-dependent dehydrogenase;Tdh;HELO_RS00970;ER;;;1.1.1.-;HELO_1190;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);0.5428985505422217;0.012561495606395745;0.5691586745877197;-1.2390965574145438;-1.7819951079567655
HELO_1191;34.57103634029601;19.410338274671048;37.56742095713047;31.542523767029426;49.30813201700147;33.7782494859136;1.8337130303987959;2.965721499728014;3.651204987801859;0.8069344621940768;3.445832385548897;2.6165732280662124;HELO_1191;DUF2291 family protein;COG5618;Predicted periplasmic lipoprotein;;HELO_RS00975;S;;;;HELO_1191;DUF2291 family protein;0.8014029136931704;0.14919735624592612;0.5326063036910469;0.032517688592046845;-0.7688852251011236
HELO_1192;20.74116125896992;10.619132673128794;36.244641591737114;30.956845005063148;56.939047396609624;36.31884644902366;0.46592974192292397;0.5646269100282293;1.2485440688498752;0.9127670267603406;2.3357857801143442;1.7174768301045413;HELO_1192;ABC-type transport system ATP-binding protein;COG1129;ABC-type sugar transport system, ATPase component;MglA;HELO_RS00980;G;;;;HELO_1192;ABC-type transport system ATP-binding protein;0.9039266202670606;-0.0028715130628338414;0.6346315725771046;-0.779475391209747;-1.6834020114768076
HELO_1193;18.6249124845219;11.18409340999865;32.29807817511165;27.946790244494476;51.92775291267139;34.342103857484844;0.861222310650569;0.6863051240332887;1.0763297761420263;2.711098987659362;4.068329381815717;1.088430407465699;HELO_1193;ABC-type transport system permease protein;COG1172;Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component;AraH;HELO_RS00985;G;;;;HELO_1193;ABC-type transport system permease protein;0.6876873129754797;-0.08594901030043722;0.5826364808604687;-0.8487017032619093;-1.536389016237389
HELO_1194;35.426578416191454;29.455361485685373;169.60560445101228;169.85561103026654;269.5499223919453;170.7544818826658;0.9838049033318872;3.4527042081117365;8.18445317785757;7.439293656545475;15.64373356231338;23.535166567576713;HELO_1194;ABC-type transport system periplasmic substrate-binding protein;COG1879;ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain;RbsB;HELO_RS00990;G;;;;HELO_1194;ABC-type transport system periplasmic substrate-binding protein;0.2582952593098522;-0.009682705789184176;0.6555470812418829;-2.2372843534229334;-2.4955796127327856
HELO_1195;128.30281143347813;84.5733889355924;144.98757995905942;161.35532701342106;217.22570026435275;130.85843849172804;3.2672082734124603;3.525832896534397;15.953621393588383;5.829447036792053;36.646445227183406;27.349483376804727;ribH2;6%2C7-dimethyl-8-ribityllumazine synthase;COG0054;6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain);RibE;HELO_RS00995;H;ribH2; 6,7-dimethyl-8-ribityllumazine synthase;2.5.1.78;ribH2;6%2C7-dimethyl-8-ribityllumazine synthase;0.5955195126161765;0.14685573385287043;0.7268311149618958;-0.02823625769940019;-0.6237557703155767
HELO_1196;0.9306997598692736;1.3749269462643074;54.33563270738072;44.19100087772433;54.24466979972397;55.53184625723716;0.28560556774599966;0.18941790227515873;5.742565463274929;3.145080705294158;5.579742820993059;10.046108094784932;tktA3;transketolase;COG0021;Transketolase;TktA;HELO_RS01000;G;tktA3; transketolase;2.2.1.1;tktA3;transketolase;-0.29875930577096566;-0.03085502870639445;-0.033228539402347046;-4.871868078752043;-4.573108772981078
HELO_1197;451.3590436042611;426.30815671442315;442.72695055456956;358.9163308565403;452.65828738027636;455.91368559870625;16.675403751295935;12.95696414514547;26.30937531558209;12.271099627396703;3.936747544096487;40.376078273432014;metK;S-adenosylmethionine synthase;COG0192;S-adenosylmethionine synthetase;MetK;HELO_RS01005;H;metK; S-adenosylmethionine synthase;2.5.1.6;metK;S-adenosylmethionine synthase;0.08219145793388449;-0.04224947467640838;-0.010315641190175029;-0.01445334093015127;-0.09664479886403576
HELO_1198;278.2115337910447;207.0168159018599;239.3492269865081;221.84349639183827;236.2961473804033;224.04657471322164;4.9012681581100646;21.30645826117715;5.022156724064563;3.9441706525537437;11.907442509257175;6.304237670678817;ligB;DNA ligase (NAD) LigB;COG0272;NAD-dependent DNA ligase;Lig;HELO_RS01010;L;ligB; DNA ligase (NAD) LigB;6.5.1.2;ligB;DNA ligase (NAD) LigB;0.4246583789340894;0.09490855690104016;0.07646507128626201;0.3111349316779064;-0.11352344725618302
HELO_1199;72.78640476674315;29.316296739647807;59.791489736150005;82.19520174744214;99.26618049131052;58.48189962017572;1.400422236165365;0.26374848229405234;0.8065074800977128;2.2005015471464278;12.678513230877941;3.005509847703744;ahcY;S-adenosyl-L-homocysteine hydrolase;COG0499;S-adenosylhomocysteine hydrolase;SAM1;HELO_RS01015;H;ahcY; S-adenosyl-L-homocysteine hydrolase;3.3.1.1;ahcY;S-adenosyl-L-homocysteine hydrolase;1.2832614893478862;0.03141865123949561;0.7533124436053962;0.31090430029997584;-0.9723571890479104
HELO_1200;13.4210997534802;9.16225136991986;8.585962544208547;10.641473760581887;11.812233348930995;8.139228154735521;0.7714075194015313;0.37003726710663115;1.2101692952575873;0.8790774116346608;1.1514830332017119;0.2751289398448245;HELO_1200;uncharacterized protein;COG2908;UDP-2,3-diacylglucosamine pyrophosphatase LpxH;LpxH;HELO_RS01020;M;;ahcY;;HELO_1200;uncharacterized protein;0.5049611330461299;0.06885097392067197;0.48737774520509225;0.6580369547059064;0.1530758216597765
HELO_1201;19.59483993463051;14.000298146470891;38.96413532434328;36.44527822404746;47.550083372377664;40.199061436331796;0.47657632811187983;2.489417172960784;4.734391657400904;0.9602384325150695;4.1008751556572705;2.8252189917532347;HELO_1201;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS01025;K;;;;HELO_1201;TetR family transcription regulator;0.4572917373994465;-0.0439055964689814;0.23686230163488275;-1.00032855800763;-1.4576202954070765
HELO_1202;14.81951605940977;10.461996280073073;22.298750544462525;31.58973978205294;29.390944384616905;19.191497224868666;0.4843212136435119;0.4710233392097556;1.356839290610465;4.5111103931352945;1.7937967699339932;0.7636350812046607;HELO_1202;glutathione S-transferase domain protein;COG0625;Glutathione S-transferase;GstA;HELO_RS01030;O;;;2.5.1.18;HELO_1202;glutathione S-transferase domain protein;0.4648471333273334;0.20650469643034697;0.5898936143571687;-0.35204242580921985;-0.8168895591365533
HELO_1203;84.37549334025637;33.796135157243775;102.09414867710784;79.16561888271518;78.07588619269409;114.38657345668408;2.227906703593989;3.5280999186390445;6.471063107606403;1.7040604418786585;10.743103676841303;6.82231204737961;HELO_1203;uncharacterized protein;COG0679;Predicted permease, AEC (auxin efflux carrier) family;YfdV;HELO_RS01035;R;;;;HELO_1203;uncharacterized protein;1.294894936665134;-0.16251290786271078;-0.5451656357009718;-0.434581444615433;-1.7294763812805671
HELO_1204;219.86306745794266;1204.445323363152;821.9912957085138;359.2596586267767;254.6227837642031;785.5105183962595;22.734979018424042;26.208457856160827;122.6224587832511;25.748896359704375;16.272320195331265;72.29445937164957;metF;5%2C10-methylenetetrahydrofolate reductase;COG0685;5,10-methylenetetrahydrofolate reductase;MetF;HELO_RS01040;E;metF; 5,10-methylenetetrahydrofolate reductase;1.5.1.20;metF;5%2C10-methylenetetrahydrofolate reductase;-2.448342116919843;0.06541111254848708;-1.6214496296280068;-1.8323138670751256;0.6160282498447174
HELO_1205;27.671680711369376;30.595800417003574;45.213009704652954;85.69642098924544;36.169169360180824;47.57358636927455;3.914327228279541;1.9433037683118455;3.575535821119693;10.50211179886114;2.863340323440934;2.5892721732127546;HELO_1205;TRAP transporter 4TM/12TM fusion protein;COG4666;TRAP-type uncharacterized transport system, fused permease components;;HELO_RS01045;R;;metF;;HELO_1205;TRAP transporter 4TM/12TM fusion protein;-0.14010633738674816;-0.07187295920567838;-0.3860655619943012;-0.7605455331509869;-0.6204391957642388
HELO_1206;173.75740090143805;125.8220949361177;289.26650795636004;567.9467955396873;255.92274423510207;290.80311416337014;19.06468152311393;8.333070134499296;14.73648004450155;52.39188756542543;12.036788853436164;25.862734762903273;HELO_1206;TRAP transporter substrate-binding protein;COG2358;TRAP-type uncharacterized transport system, periplasmic component;Imp;HELO_RS01050;R;;;;HELO_1206;TRAP transporter substrate-binding protein;0.46254744081522503;-0.007617162003439759;-0.18366066867162623;-0.73964172556534;-1.202189166380565
HELO_1207;10.985589824508358;6.368329211677119;18.412998636641845;25.737150422780033;11.655171933986319;18.210434802104423;0.9738706820010187;1.269185174124633;2.186647760874083;6.089769697554409;0.32734856582798944;2.303640278581889;HELO_1207;uncharacterized protein;COG1082;Sugar phosphate isomerase/epimerase;YcjR;HELO_RS01055;G;;;;HELO_1207;uncharacterized protein;0.7018914808338965;0.0151328089180085;-0.6021630646859837;-0.6805892654181012;-1.3824807462519977
HELO_1208;11.288760832100662;4.041790611394917;10.579257696685774;12.946436397001;5.397147121403516;7.153014100089066;0.4796001950677252;0.9261723695777214;1.4852213583400309;3.8975992291688017;0.4129622298154024;2.6340337249587806;HELO_1208;uncharacterized protein;COG3622;Hydroxypyruvate/dehydroerythronate isomerase, Hyi/OtnI family;Hyi;HELO_RS01060;G;;;5.3.1.22;HELO_1208;uncharacterized protein;1.2853313367281665;0.5061373552812012;-0.34990484735960603;0.5919340301103322;-0.6933973066178343
HELO_1209;18.524297539553967;12.677716998004735;52.99270246807859;65.19111230766292;52.74847547602755;48.623242205462304;1.3495254109306702;0.4477931793158838;3.2619105274542415;3.7698017040544345;5.047143269274863;9.914522504839047;lacA;GMC family oxidoreductase (homolog to lactose dehydrogenase flavoprotein subunit);COG2303;Choline dehydrogenase or related flavoprotein;BetA;HELO_RS01065;IR;lacA; GMC family oxidoreductase (homolog to lactose dehydrogenase flavoprotein subunit);;lacA;GMC family oxidoreductase (homolog to lactose dehydrogenase flavoprotein subunit);0.5134431985235928;0.12174843019099324;0.11520783576833082;-1.3457453559619825;-1.8591885544855753
HELO_1210;10.29979875323791;5.972434062244054;16.197444258425765;19.051252942624355;17.55557479026687;13.962975510022616;1.6616653062231792;0.7797638697205836;2.6683423581146264;1.1337801116285928;1.5232697402878557;2.0853153210865103;HELO_1210;homolog to lactose dehydrogenase small subunit;;;;;;;;;HELO_1210;homolog to lactose dehydrogenase small subunit;0.6965627878312399;0.20079708402253926;0.31045559618345964;-0.4051000166501706;-1.1016628044814105
HELO_1211;28.713110075232205;20.358769479250995;50.79713115051996;54.026070643301466;53.46188743548162;41.165523773036774;2.077665498136343;1.4510139319861284;4.583839549777561;0.664041353768141;5.552452009853289;3.421436897949714;HELO_1211;DUF1080 family protein;;;;;;;;;HELO_1211;DUF1080 family protein;0.47627108724227796;0.2968083191733628;0.36918310593601955;-0.5049642553045839;-0.9812353425468618
HELO_1212;134.3357927990278;69.44617906031546;119.94758849994291;291.2171305977524;134.08372237840425;129.6175560905979;23.53232248555117;4.290974639220355;11.031084109057915;18.361165052902205;9.701992203580458;16.531923954337277;HELO_1212;DUF2387 domain protein;COG3529;Predicted nucleic-acid-binding protein, contains Zn-ribbon domain;;HELO_RS01080;R;;;;HELO_1212;DUF2387 domain protein;0.9419500818721227;-0.11096681559174293;0.04850501985001365;0.051194624931788724;-0.890755456940334
HELO_1213;162.265600441301;79.51069905137079;193.49649939001435;430.3582201229851;182.61464318982374;201.8591383485112;25.27762772053015;3.785326661227781;9.20783141271704;41.8271638737083;17.09362835334452;9.208141256767432;prlC;oligopeptidase A;COG0339;Zn-dependent oligopeptidase, M3 family;Dcp;HELO_RS01085;O;prlC; oligopeptidase A;3.4.24.70;prlC;oligopeptidase A;1.0199684309730817;-0.0607341048190273;-0.14379717652239332;-0.31325744265856237;-1.333225873631644
HELO_1214;105.35370426240466;159.10594954337088;141.7472286217999;163.71745397973388;142.77224087773024;140.26593714320913;1.5579687509675866;2.8048700396298916;3.838203811381938;10.988525424502047;5.511544245577179;4.950456645925598;HELO_1214;NSS family transport protein;COG0733;Na+-dependent transporter, SNF family;YocR;HELO_RS01090;R;;prlC;;HELO_1214;NSS family transport protein;-0.5901566367161566;0.015049099870714677;0.025371514676946205;-0.40954335392534524;0.18061328279081135
HELO_1215;198.2680363955035;265.23632410924034;240.82767160682386;228.7108897833053;268.47821569003656;238.6039271060373;13.934005738030596;6.309761189207559;11.84541383888629;1.8758878889043353;12.134526507605512;21.37091834187669;yrdA;YrdA family protein YrdA;COG0663;Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily;PaaY;HELO_RS01095;R;yrdA; YrdA family protein YrdA;;yrdA;YrdA family protein YrdA;-0.4179971064962551;0.013327783171354746;0.16951709780043345;-0.2659412409505659;0.15205586554568917
HELO_1216;102.44928576868153;108.83896188585008;76.24654709236624;68.07191025313637;72.85643320057014;76.28112950366214;4.938408488698823;1.7481791992105173;1.2920472782535282;2.6382546114160257;5.615820523141672;9.697107432721834;HELO_1216;DUF457 domain protein;;;;;;;;;HELO_1216;DUF457 domain protein;-0.08646621078576722;-0.0006457338285352776;-0.06539258889781596;0.4207355994480828;0.50720181023385
HELO_1217;39.44743313271667;24.013570465006282;25.2592886745756;25.8059119036452;30.939951167590298;23.090402406892405;2.8478552750769754;0.738775685134984;3.2541051520502484;1.6431178801211166;1.7819363155740873;2.1080090379989267;HELO_1217;response regulator/sigma-54-interact/HTH domain transcription regulator;COG2204;DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains;AtoC;HELO_RS01105;T;;;;HELO_1217;response regulator/sigma-54-interact/HTH domain transcription regulator;0.6933371454024755;0.12436934367379315;0.40690361443648904;0.7475896569187279;0.05425251151625243
HELO_1218;33.67177028750424;23.64260972167001;18.68361006876952;19.315517919512825;18.99307077251269;18.519499686896545;2.2879544605104463;1.7514124346017468;1.4218745482069663;0.8774197873567456;1.4284313955488166;1.98467144723443;HELO_1218;sensor histidine kinase;COG4191;Signal transduction histidine kinase regulating C4-dicarboxylate transport system;;HELO_RS01110;T;;;2.7.13.3;HELO_1218;sensor histidine kinase;0.4926064506355887;0.012078767147356118;0.034584000278865545;0.8288454252140136;0.3362389745784249
HELO_1219;77.93164041431176;55.51357554292105;70.55734199869413;84.39350959342417;87.04703208837691;70.82228825938368;6.8885136009544;4.414282770388852;3.797109039975064;7.616858317700273;8.65392192835759;2.0790040253976807;lldR;GntR family transcription regulator LldR;COG2186;DNA-binding transcriptional regulator, FadR family;FadR;HELO_RS01115;K;lldR; GntR family transcription regulator LldR;;lldR;GntR family transcription regulator LldR;0.48200626308703765;-0.005331818624086715;0.29384275612231825;0.13617211464147605;-0.3458341484455616
HELO_1220;144.96893833110101;153.61537619263072;121.57976870271568;158.97041390703006;112.25436916383212;115.92934003127091;9.512061593955261;4.823278855607944;6.553226260724277;2.4411494177735986;4.4812351046029315;7.142127453931784;lldD;L-lactate dehydrogenase (cytochrome);COG1304;FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase;LldD;HELO_RS01120;CIR;lldD; L-lactate dehydrogenase (cytochrome);1.1.2.3;lldD;L-lactate dehydrogenase (cytochrome);-0.08302239814755641;0.06808390983824708;-0.04607026972720529;0.3200244235812413;0.4030468217287977
HELO_1221;186.730999027134;150.04156681224399;188.3058687471818;178.2517943577433;220.2627452880391;150.99173578967756;14.892501749894421;6.830465303384118;11.692200809563127;25.386173285906306;16.417036972017257;9.780006141644307;birA;bifunctional biotin--acetyl-CoA-carboxylase ligase / transcription regulator;COG1654;Biotin operon repressor;BirA;HELO_RS01150;K;birA; bifunctional biotin--acetyl-CoA-carboxylase ligase / transcription regulator;6.3.4.15;birA;bifunctional biotin--acetyl-CoA-carboxylase ligase / transcription regulator;0.3137212589220102;0.3167262548139105;0.5417676779464644;0.30467401195362687;-0.009047246968383327
HELO_1222;159.7102837759454;124.71047872239693;124.92728558930514;108.64514251488157;160.8786411399643;97.82895810760948;4.8323962796380755;5.160209186573781;3.8751648728973573;9.134532204175809;15.850530123873142;12.820558536702308;coaX;pantothenate kinase%2C type III;COG1521;Pantothenate kinase type III;CoaX;HELO_RS01155;H;coaX; pantothenate kinase, type III;2.7.1.33;coaX;pantothenate kinase%2C type III;0.3543573372926385;0.3495851798872538;0.7119069073711852;0.7014565129827792;0.3470991756901407
HELO_1223;1327.5758815331626;1911.5369870088573;908.3774172889403;993.7618189202316;880.8478131873748;872.6869452561331;100.81797213895098;160.63274792691607;82.47950665308691;54.643410013549556;137.25515933489717;96.29048911703774;secE;protein translocase subunit SecE;COG0690;Preprotein translocase subunit SecE;SecE;HELO_RS01180;U;secE; protein translocase subunit SecE;;secE;protein translocase subunit SecE;-0.525607019074652;0.0577627441626376;0.013413267322132327;0.6046922908172441;1.130299309891896
HELO_1224;2743.2220791120103;4578.6813299258265;1562.1855774606327;1385.1112320486639;1391.4591364338346;1590.5433064843062;124.08837728520987;198.33230798376354;235.75171554175864;84.67997288782499;253.2441861937516;187.10953827938468;nusG;transcription elongation factor NusG;COG0250;Transcription termination/antitermination protein NusG;NusG;HELO_RS01185;K;nusG; transcription elongation factor NusG;;nusG;transcription elongation factor NusG;-0.73884997622452;-0.025937352143582615;-0.19279142339476607;0.7859708241013799;1.5248208003258998
HELO_1225;2540.0388683429105;3383.4961662076935;2545.6964819787795;2671.689395392195;2223.602217840932;2536.429967387054;25.466833483009726;61.83888901808046;267.976138290582;277.66973774279336;147.31525136485124;115.00536768211626;rplK;50S ribosomal protein L11;COG0080;Ribosomal protein L11;RplK;HELO_RS01190;J;rplK; 50S ribosomal protein L11;;rplK;50S ribosomal protein L11;-0.4135226392875797;0.005259023190969714;-0.18982061455476362;0.002050438648696584;0.4155730779362763
HELO_1226;3012.4215763906836;4442.161357766287;4448.628484971909;4859.142643727229;3875.1642587649244;4491.251076576668;202.946202081923;160.995753428988;328.340595633377;554.5959840557223;25.51768367415865;234.10371974814188;rplA;50S ribosomal protein L1;COG0081;Ribosomal protein L1;RplA;HELO_RS01195;J;rplA; 50S ribosomal protein L1;;rplA;50S ribosomal protein L1;-0.5601840157144249;-0.013753678257625523;-0.21280885511836978;-0.576036044244157;-0.01585202852973211
HELO_1227;4981.627700181357;5666.681537006431;8027.2314914063745;8782.212809883955;7395.131242617659;8378.484417831627;276.59291741144705;483.531296112521;707.2518649628478;1412.2951033391273;438.5660885662589;194.41669294998852;rplJ;50S ribosomal protein L10;COG0244;Ribosomal protein L10;RplJ;HELO_RS01200;J;rplJ; 50S ribosomal protein L10;;rplJ;50S ribosomal protein L10;-0.18585191603547813;-0.061779261986348644;-0.18009065366712562;-0.7499546984323562;-0.564102782396878
HELO_1228;8590.127732709994;9397.465205073582;8419.536044494138;7884.559684466709;7098.988285443458;7742.282654424359;296.3531481489393;259.5736204059301;381.49076059579176;655.6221451931387;364.8684171582177;689.5045607706783;rplL;50S ribosomal protein L7/L12;COG0222;Ribosomal protein L7/L12;RplL;HELO_RS01205;J;rplL; 50S ribosomal protein L7/L12;;rplL;50S ribosomal protein L7/L12;-0.12957765776466523;0.1209667709430935;-0.125128661809347;0.1499022161687762;0.2794798739334414
HELO_1229;761.631796895486;1175.2974026433178;1240.488838737127;1401.5715162246572;1323.4561957372796;1258.9281526572302;25.08235697435734;59.90087398137091;125.29669614145052;127.99383869923462;136.092193029996;109.76362373674206;rpoB;DNA-directed RNA polymerase beta subunit;COG0085;DNA-directed RNA polymerase, beta subunit/140 kD subunit;RpoB;HELO_RS01210;K;rpoB; DNA-directed RNA polymerase beta subunit;2.7.7.6;rpoB;DNA-directed RNA polymerase beta subunit;-0.6251942734701803;-0.021270175033627936;0.07205866321886667;-0.7242828778168384;-0.09908860434665812
HELO_1230;673.1503014971145;1194.6231077144496;1220.3864540976708;1340.7514330727315;1327.0085063486065;1210.6416565262864;25.147391522044366;58.749288780240015;120.17506979065298;123.60885397310012;139.57277438846;123.79898274396893;rpoC;DNA-directed RNA polymerase beta' subunit;COG0086;DNA-directed RNA polymerase, beta' subunit/160 kD subunit;RpoC;HELO_RS01215;K;rpoC; DNA-directed RNA polymerase beta' subunit;2.7.7.6;rpoC;DNA-directed RNA polymerase beta' subunit;-0.82662050468136;0.01155666574154246;0.13230130337472978;-0.8458209037236362;-0.019200399042276217
HELO_1231;2349.255660414659;2981.5624921891445;3974.173663099497;3878.9267027652145;3356.550926147907;3662.1859616305287;87.98578132687489;112.19653958229497;284.1855173183541;97.91427601712418;112.97217608988217;254.9676054610567;rpsL;30S ribosomal protein S12;COG0048;Ribosomal protein S12;RpsL;HELO_RS01220;J;rpsL; 30S ribosomal protein S12;;rpsL;30S ribosomal protein S12;-0.3437346648784505;0.11791894736129649;-0.12568965920929465;-0.6402812398673117;-0.29654657498886117
HELO_1232;3388.463697585778;6185.491997131325;3435.1709192890507;3092.029878435176;3044.091449268433;3289.893775641957;168.22365462805521;292.5256300123193;249.04926473424842;189.70976204013334;217.66736344775003;177.20427312588467;rpsG;30S ribosomal protein S7;COG0049;Ribosomal protein S7;RpsG;HELO_RS01225;J;rpsG; 30S ribosomal protein S7;;rpsG;30S ribosomal protein S7;-0.8680645530548379;0.062322340140221755;-0.11199390414889798;0.042577559558376166;0.910642112613214
HELO_1233;3233.6652790977732;5990.8659730232275;4678.3735922371125;4427.166098542884;4836.66252493023;4754.756320758497;168.1208127439398;373.0499871701065;214.4831151340542;424.6400971243444;149.14016070779473;199.18348167777708;fusA;translation elongation factor G;COG0480;Translation elongation factor EF-G, a GTPase;FusA;HELO_RS01230;J;fusA; translation elongation factor G;;fusA;translation elongation factor G;-0.889388922866754;-0.023359379707370564;0.02463533548560015;-0.5560583641493899;0.33333055871736406
HELO_1234;8632.989124414044;8919.37999882624;10337.819156925594;10378.556749501146;11129.13038223962;9966.72942461681;479.1595707216361;656.9482127084235;458.57258858410506;1020.6905299837002;314.7269501960085;367.0417662011214;tuf;translation elongation factor Tu;COG0050;Translation elongation factor EF-Tu, a GTPase;TufA;HELO_RS01235;J;tuf; translation elongation factor Tu;;tuf;translation elongation factor Tu;-0.04707789320308997;0.05273460651620532;0.15913368116189908;-0.20723763119235272;-0.16015973798926275
HELO_1235;5373.692729489111;11512.096696842198;9288.669483588435;8963.796862595738;7562.932656324715;7832.675431992323;527.1173697132829;823.5403746647573;820.4708201666867;689.3981691745851;385.45708737288;1157.1307503724772;rpsJ;30S ribosomal protein S10;COG0051;Ribosomal protein S10;RpsJ;HELO_RS01240;J;rpsJ; 30S ribosomal protein S10;;rpsJ;30S ribosomal protein S10;-1.0990217462826717;0.24593791278623556;-0.05055283654999165;-0.5435070768380292;0.5555146694446425
HELO_1236;2602.0685579923634;4151.135873984177;5489.367101374492;5759.973492270562;5305.9016641975395;5375.9894146123615;251.96510549553258;341.68254242307967;575.9975133975121;426.249385654998;166.62505519038606;395.4882674845059;rplC;50S ribosomal protein L3;COG0087;Ribosomal protein L3;RplC;HELO_RS01245;J;rplC; 50S ribosomal protein L3;;rplC;50S ribosomal protein L3;-0.6736403460010418;0.030103983639834908;-0.018928815307482694;-1.0465853224181565;-0.37294497641711466
HELO_1237;1789.2778429652956;2758.921638994214;2156.5245095908217;2132.4372627430107;2308.4647120759087;2404.247903444855;77.81527064424056;69.59764861342866;272.6522408872238;342.7557301709764;77.88955882538998;222.09508802649594;rplD;50S ribosomal protein L4;COG0088;Ribosomal protein L4;RplD;HELO_RS01250;J;rplD; 50S ribosomal protein L4;;rplD;50S ribosomal protein L4;-0.6244438013389111;-0.15680864837550956;-0.05862709455328918;-0.4260020924003243;0.1984417089385868
HELO_1238;1630.675408580587;3942.777259768604;791.991062193886;688.7323909145651;737.7867151254171;859.4103908367324;165.83581284205454;233.3972627561544;256.891047372831;133.06666819015786;230.54287627111987;190.50773819309964;rplW;50S ribosomal protein L23;COG0089;Ribosomal protein L23;RplW;HELO_RS01255;J;rplW; 50S ribosomal protein L23;;rplW;50S ribosomal protein L23;-1.2732239836213903;-0.11772034232675921;-0.21986702373664357;0.9232572357179887;2.196481219339379
HELO_1239;1987.149042231077;3118.6073523435857;3069.180020121483;2917.402828986003;3134.7421385589782;3282.74382276025;196.62274934671564;145.40865116105098;290.525359064154;353.05565531453476;38.976787170145464;156.36464192674518;rplB;50S ribosomal protein L2;COG0090;Ribosomal protein L2;RplB;HELO_RS01260;J;rplB; 50S ribosomal protein L2;;rplB;50S ribosomal protein L2;-0.6499385434485188;-0.09701833087084744;-0.06653465421573301;-0.7239156683736496;-0.07397712492513087
HELO_1240;5153.799755818217;12854.433993860452;3727.3113248791574;3453.990414636106;3452.101399135962;4071.059114724188;553.37045095717;659.2510106670497;810.8066998020643;425.86592894924473;984.6205042342838;478.9188376782695;rpsS;30S ribosomal protein S19;COG0185;Ribosomal protein S19;RpsS;HELO_RS01265;J;rpsS; 30S ribosomal protein S19;;rpsS;30S ribosomal protein S19;-1.3183900251202871;-0.12723617112739305;-0.23786580633957755;0.3401578801208984;1.6585479052411856
HELO_1241;2365.7340509941255;5234.461433047665;2306.5020057555316;2328.02839848718;2398.813130589813;2672.3274608369866;296.3738302131717;391.36869063341317;231.8817727890592;422.4516298838712;308.7180275766043;164.89480267082862;rplV;50S ribosomal protein L22;COG0091;Ribosomal protein L22;RplV;HELO_RS01270;J;rplV; 50S ribosomal protein L22;;rplV;50S ribosomal protein L22;-1.1454190961585695;-0.21230466488656674;-0.15571449682314586;-0.17573896670867306;0.9696801294498965
HELO_1242;1986.3371007679743;4127.8192764923615;2992.436672328176;3175.857233482255;3075.917056688099;3109.014996956567;224.2315776568821;398.2390335107463;208.8854447362903;482.1080931545695;146.63160179304643;105.52069168740188;rpsC;30S ribosomal protein S3;COG0092;Ribosomal protein S3;RpsC;HELO_RS01275;J;rpsC; 30S ribosomal protein S3;;rpsC;30S ribosomal protein S3;-1.0548926618000074;-0.05511878764563072;-0.015435983263012432;-0.6460849277071716;0.4088077340928358
HELO_1243;1842.1836641028985;2779.439669433299;1812.5047329576448;1898.4196796490342;1747.4022769105432;1767.1073140094556;157.81283105238543;227.92120008550836;261.08447123390863;312.36919622536846;163.6688189651156;224.23680657056272;rplP;50S ribosomal protein L16;COG0197;Ribosomal protein L16/L10AE;RplP;HELO_RS01280;J;rplP; 50S ribosomal protein L16;;rplP;50S ribosomal protein L16;-0.593113198049771;0.03657466978577517;-0.01616867869956451;0.05999399480008982;0.6531071928498609
HELO_1244;2744.5089747142542;5921.472239851012;151.82938732093066;144.04877026584407;173.04880158463587;191.28180678803082;129.9011966077584;326.5094797634735;62.81489803259101;45.2061300405182;111.7217301955685;65.73960238397073;rpmC;50S ribosomal protein L29;COG0255;Ribosomal protein L29;RpmC;HELO_RS01285;J;rpmC; 50S ribosomal protein L29;;rpmC;50S ribosomal protein L29;-1.109125903925392;-0.3313002814322301;-0.1437303846266884;3.8357794571346355;4.9449053610600275
HELO_1245;2111.5681834029947;4323.588959085146;736.4137805590896;705.3473293495821;748.6857386903972;777.8284144671538;305.224823186889;421.2116348408655;173.5090946000487;143.00792868196243;195.57977424664168;120.64742082406727;rpsQ;30S ribosomal protein S17;COG0186;Ribosomal protein S17;RpsQ;HELO_RS01290;J;rpsQ; 30S ribosomal protein S17;;rpsQ;30S ribosomal protein S17;-1.0335651095506577;-0.07883114241308675;-0.05501956178607337;1.439620480464562;2.4731855900152198
HELO_1246;4621.0067369217695;9922.713121890612;2672.2409848393872;2620.0366383334244;2661.0072580976903;2865.1454889604624;422.34411740764574;524.6632600765992;528.1273869396798;435.397044971382;743.5964880180981;478.9634003086056;rplN;50S ribosomal protein L14;COG0093;Ribosomal protein L14;RplN;HELO_RS01295;J;rplN; 50S ribosomal protein L14;;rplN;50S ribosomal protein L14;-1.102360667265712;-0.10052194620558197;-0.10659733954197215;0.6894075182651154;1.7917681855308274
HELO_1247;5095.48241017786;11390.488728531287;2311.9069534966125;2177.639044843558;2335.416619430426;2701.027506962162;700.8230985906446;673.876169949887;693.9235421326938;368.25172328760874;862.176070998822;509.4967111447121;rplX;50S ribosomal protein L24;COG0198;Ribosomal protein L24;RplX;HELO_RS01300;J;rplX; 50S ribosomal protein L24;;rplX;50S ribosomal protein L24;-1.160382553784002;-0.22433513293844243;-0.20974480941941565;0.9154594815568764;2.0758420353408784
HELO_1248;4860.036412480574;10542.326945330125;4819.3442117303675;5215.899301135788;5178.6732444573245;5250.691279120101;480.35505237942044;481.7516078594769;796.3538455629383;791.2205102081629;942.0466523985348;520.3058524666814;rplE;50S ribosomal protein L5;COG0094;Ribosomal protein L5;RplE;HELO_RS01305;J;rplE; 50S ribosomal protein L5;;rplE;50S ribosomal protein L5;-1.1169943349825058;-0.1236459395603351;-0.01992102031835863;-0.11151816890079402;1.0054761660817118
HELO_1249;2036.9997863061271;3877.3784115297676;683.4423106043714;688.4077207674787;736.1958426026723;693.170795048682;183.97536064877633;338.70176000017926;157.51993324763853;114.36103959785802;217.1888568796979;140.44816892291738;rpsN;30S ribosomal protein S14;COG0199;Ribosomal protein S14;RpsN;HELO_RS01310;J;rpsN; 30S ribosomal protein S14;;rpsN;30S ribosomal protein S14;-0.9282996731481603;-0.020361723219879835;0.08675726515117965;1.5537913253195725;2.482090998467733
HELO_1250;2458.7637807176357;4725.541715382838;1165.4387444327797;1203.9604761438457;1262.83009267821;1118.1938034171249;299.0698157964095;452.85873608922424;78.95898395267174;169.61822722791308;163.93473048626933;113.55299421441735;rpsH;30S ribosomal protein S8;COG0096;Ribosomal protein S8;RpsH;HELO_RS01315;J;rpsH; 30S ribosomal protein S8;;rpsH;30S ribosomal protein S8;-0.9422652126092359;0.05965066619426196;0.1753426429664504;1.136059895480221;2.078325108089457
HELO_1251;2148.6958265855114;3879.366448308999;2305.765785956633;2489.969656401571;2695.3041122214895;2529.5612963681506;183.4538214374848;359.5832895069668;138.33720733416482;404.70270752808483;222.02683364030008;122.82443843328629;rplF;50S ribosomal protein L6;COG0097;Ribosomal protein L6P/L9E;RplF;HELO_RS01320;J;rplF; 50S ribosomal protein L6;;rplF;50S ribosomal protein L6;-0.8520603633050783;-0.13358589080815797;0.09152580481011796;-0.23532488172141797;0.6167354815836603
HELO_1252;2925.2263310149515;4673.842430681994;2010.9785349239617;1943.4084895260928;2229.982963687866;2104.6137882776966;243.97420915375244;248.18162524626678;225.83979958992674;324.40544429190356;342.2477343083067;305.4392978972533;rplR;50S ribosomal protein L18;COG0256;Ribosomal protein L18;RplR;HELO_RS01325;J;rplR; 50S ribosomal protein L18;;rplR;50S ribosomal protein L18;-0.6758763785795558;-0.06562592784567478;0.08343865538827444;0.4748005185691575;1.1506768971487134
HELO_1253;2368.317622697956;2966.615168641527;2360.5095445024585;2394.8228629587934;2915.476451568618;2448.777586583263;57.3645121941508;167.72372755430132;316.6669455245864;456.743585718534;51.60205395117705;411.5605194434562;rpsE;30S ribosomal protein S5;COG0098;Ribosomal protein S5;RpsE;HELO_RS01330;J;rpsE; 30S ribosomal protein S5;;rpsE;30S ribosomal protein S5;-0.32483240540400615;-0.05294140756951471;0.25157565147914873;-0.04817915964884456;0.2766532457551616
HELO_1254;5730.9864188592355;11266.009196274557;237.23039296126066;214.30873500395978;259.65761611014176;282.82837745187913;856.4096316959084;767.9677113618533;71.5358144247842;59.81451740471124;155.12885914241397;93.4352023464146;rpmD;50S ribosomal protein L30;COG1841;Ribosomal protein L30/L7E;RpmD;HELO_RS01335;J;rpmD; 50S ribosomal protein L30;;rpmD;50S ribosomal protein L30;-0.9749975095339849;-0.2526613576204291;-0.12286282432896733;4.335944447489689;5.310941957023674
HELO_1255;2022.0631613402766;3225.176892914729;1705.2345370518567;1618.8791773683504;1810.841864290763;1786.4202142372185;147.63210712603967;276.72539063760973;181.50926851104123;233.92706888759184;200.8263347350865;192.19246558464624;rplO;50S ribosomal protein L15;COG0200;Ribosomal protein L15;RplO;HELO_RS01340;J;rplO; 50S ribosomal protein L15;;rplO;50S ribosomal protein L15;-0.6732841818912867;-0.06706287369467745;0.019578198732155272;0.1786625172760612;0.8519466991673479
HELO_1256;2329.234006245439;4358.2017909210435;3012.4483908693787;3407.5247653977563;3254.7570325142665;3088.404444135689;137.49446995251648;244.72967605200796;140.51103300531042;371.7404889437116;180.64793838692964;102.139978944037;secY;protein translocase subunit SecY;COG0201;Preprotein translocase subunit SecY;SecY;HELO_RS01345;U;secY; protein translocase subunit SecY;;secY;protein translocase subunit SecY;-0.9035891485818848;-0.03591339428105478;0.07566428827137806;-0.4068539111425622;0.4967352374393226
HELO_1257;12173.487806759402;21389.810600882323;4117.1104440541285;3998.5967708550074;3851.7515038252764;4649.801721865261;1254.062068050593;1654.995960047949;685.170673095247;492.8664445603519;1031.2076108994452;673.3374774672229;rpmJ;50S ribosomal protein L36;COG0257;Ribosomal protein L36;RpmJ;HELO_RS01350;J;rpmJ; 50S ribosomal protein L36;;rpmJ;50S ribosomal protein L36;-0.8131300762872389;-0.17549691231427467;-0.27159029707318894;1.388309738206214;2.201439814493453
HELO_1258;8711.73305916629;13239.91027957687;7650.873160481516;7151.940710083978;7103.378232789889;8662.06668092032;551.2866972673381;709.1075410459473;997.9098569173767;840.2138685727796;1002.5429218990081;605.4726520375767;rpsM;30S ribosomal protein S13;COG0099;Ribosomal protein S13;RpsM;HELO_RS01355;J;rpsM; 30S ribosomal protein S13;;rpsM;30S ribosomal protein S13;-0.6038050596071489;-0.17906486259089505;-0.28616943002803197;0.008247520552647103;0.612052580159796
HELO_1259;4848.755721811997;6763.807720346001;2884.027798425159;2828.9847717265657;3037.7304344091917;3284.302704688036;358.0253215197809;617.8715184086728;124.17714230554624;478.69843002089254;339.8927275706926;105.25582303846174;rpsK;30S ribosomal protein S11;COG0100;Ribosomal protein S11;RpsK;HELO_RS01360;J;rpsK; 30S ribosomal protein S11;;rpsK;30S ribosomal protein S11;-0.48013684653905386;-0.1874410853346049;-0.1125576060825626;0.5618857765425069;1.0420226230815608
HELO_1260;3699.165030711342;5510.931850442391;3348.4376000916586;3489.555750825061;3492.6936399472784;3551.1132172401212;139.02468709659183;267.7477629904221;103.61816040659832;393.34811928086134;204.65234810150807;121.71034268435784;rpsD;30S ribosomal protein S4;COG0522;Ribosomal protein S4 or related protein;RpsD;HELO_RS01365;J;rpsD; 30S ribosomal protein S4;;rpsD;30S ribosomal protein S4;-0.5749684329806257;-0.0847586909661775;-0.023924461063495883;0.05891205194329885;0.6338804849239246
HELO_1261;2995.5576169505753;3615.1548182682836;2643.9327558491646;2699.745208713461;2480.8758892159735;2654.930512919343;177.21545703377456;313.58393493729653;151.6154906738526;338.1264364852415;70.48420799096773;81.05303153714769;rpoA;DNA-directed RNA polymerase alpha subunit;COG0202;DNA-directed RNA polymerase, alpha subunit/40 kD subunit;RpoA;HELO_RS01370;K;rpoA; DNA-directed RNA polymerase alpha subunit;2.7.7.6;rpoA;DNA-directed RNA polymerase alpha subunit;-0.2711503312095349;-0.0059863578994168165;-0.0977864293200561;0.17408871193739373;0.44523904314692864
HELO_1262;3625.143166024079;4144.214523882085;1952.446276038753;1735.1911254058978;1562.3435986954337;1829.133289477756;196.25053919045473;368.2770473956634;95.14560928270423;146.208900524708;62.226359956088295;143.56044290955276;rplQ;50S ribosomal protein L17;COG0203;Ribosomal protein L17;RplQ;HELO_RS01375;J;rplQ; 50S ribosomal protein L17;;rplQ;50S ribosomal protein L17;-0.19301088011349776;0.09407285435846724;-0.22731382930191302;0.9864871616492863;1.179498041762784
HELO_1263;132.31076489534317;135.7971315494219;150.1760213943171;167.87160161807705;190.63504000723788;147.15288791976047;3.8353383632543956;5.87946002764299;3.2128961423391447;3.4126411799872325;5.7382185576638856;4.142217936998582;uvrA;UvrABC system protein UvrA;COG0178;Excinuclease UvrABC ATPase subunit;UvrA;HELO_RS01380;L;uvrA; UvrABC system protein UvrA;;uvrA;UvrABC system protein UvrA;-0.03724469587177648;0.029142577549514215;0.3712746297312055;-0.1522934654812076;-0.11504876960943111
HELO_1264;177.85226348341257;180.3494512616314;205.57843798762428;203.13948895950875;216.13612845705438;215.0094851798527;10.665382227397558;2.6787754612672106;4.241475034846145;5.55172108949736;5.58624561849391;11.75923226959038;HELO_1264;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS01385;G;;uvrA;;HELO_1264;major facilitator superfamily transport protein;-0.020004003293315975;-0.06440498581991161;0.007505126605503953;-0.272326287251377;-0.252322283958061
HELO_1265;704.2158212204118;468.2615195996593;671.4371575353845;561.2940014777517;767.9191361625795;715.1250868974993;14.75009903803746;26.9757256344172;43.744933071191525;18.293949625754113;65.68728560216401;14.263592828682691;ssb1;single-stranded DNA-binding protein;COG0629;Single-stranded DNA-binding protein;Ssb;HELO_RS01390;L;ssb1; single-stranded DNA-binding protein;;ssb1;single-stranded DNA-binding protein;0.5876726799929237;-0.0908121604942842;0.10262027656417239;-0.022146766442142862;-0.6098194464350666
HELO_1266;19.449680041449202;7.223455342579659;15.47064851038084;14.446603672101682;15.544944020205456;15.034475284979651;2.9670217331345756;0.741013149187834;2.6013771832192494;0.6523744669697477;1.58036765054684;3.313105393956802;nhoA;N-hydroxyarylamine O-acetyltransferase;COG2162;Arylamine N-acetyltransferase;NhoA;HELO_RS01395;Q;nhoA; N-hydroxyarylamine O-acetyltransferase;2.3.1.118;nhoA;N-hydroxyarylamine O-acetyltransferase;1.3142616507725062;0.038720216882023095;0.0452132667591254;0.35090112719248445;-0.9633605235800218
HELO_1267;150.29345068511816;131.89115924996736;120.7643147752989;132.78207239293565;123.94157946124092;119.75689923242169;7.579904439116901;3.1903345454750385;2.7455246777663556;4.008617918301616;4.426795925493956;4.237551215228247;HELO_1267;homolog to dTDP-4-dehydrorhamnose reductase;COG1091;dTDP-4-dehydrorhamnose reductase;RfbD;HELO_RS01400;M;;nhoA;1.1.1.133;HELO_1267;homolog to dTDP-4-dehydrorhamnose reductase;0.1871044056207385;0.01198577017970237;0.049148055850313455;0.3252439190891039;0.1381395134683654
HELO_1268;165.37344253251158;93.88091540893588;66.56624354790337;64.92028002319027;62.95981325125351;61.55216724130281;14.547465466125121;4.36392823140871;3.100695666021988;5.689141870457096;4.959646914753548;7.567828692022098;HELO_1268;acyltransferase domain protein;COG0204;1-acyl-sn-glycerol-3-phosphate acyltransferase;PlsC;HELO_RS01405;I;;;2.3.1.51;HELO_1268;acyltransferase domain protein;0.8102353265829043;0.11124277821015571;0.03210585624033335;1.411293385394984;0.6010580588120797
HELO_1269;848.8200018792171;891.1303016114825;902.8262050916569;903.3804593696877;735.9709599914122;897.5844455951386;42.48248312499382;58.66580164080583;63.310093429052266;35.33787178285621;57.6302086869687;2.068453160721865;fabB;3-oxoacyl-(acyl-carrier-protein) synthase FabB;COG0304;3-oxoacyl-(acyl-carrier-protein) synthase;FabB;HELO_RS01410;IQ;fabB; 3-oxoacyl-(acyl-carrier-protein) synthase FabB;2.3.1.41;fabB;3-oxoacyl-(acyl-carrier-protein) synthase FabB;-0.07009714062127337;0.008391297230616601;-0.28604631748148357;-0.0804967889771735;-0.010399648355900126
HELO_1270;765.1659115107868;691.4121910711168;1214.9675352965814;1340.6553023546255;988.9200056643549;1274.964159301234;3.0269480243200024;36.85865270252689;10.906246461800121;61.86376193874851;21.230339479093978;45.42724063740971;fabA;3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase FabA;COG0764;3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase;FabA;HELO_RS01415;I;fabA; 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase FabA;4.2.1.59,5.3.3.14;fabA;3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase FabA;0.14602571237869988;-0.06948309437917999;-0.3662039532189514;-0.735859062179749;-0.8818847745584488
HELO_1271;60.828439611539615;50.93959478916701;50.91367442845245;44.84595306848397;52.100195483262446;54.03239878894508;5.210071835789166;3.6681925891061034;2.5153578664760663;2.4624134813889906;2.096064551430927;5.345578817567109;phrB;deoxyribodipyrimidine photo-lyase;COG0415;Deoxyribodipyrimidine photolyase;PhrB;HELO_RS01420;L;phrB; deoxyribodipyrimidine photo-lyase;4.1.99.3;phrB;deoxyribodipyrimidine photo-lyase;0.2514358374385548;-0.08416661048931484;-0.05156404301038542;0.16798938100734784;-0.08344645643120696
HELO_1272;137.0070211347377;110.40927540134068;150.11619145502527;155.47319027910956;158.6285777373012;153.7609744929906;3.8588797646904016;6.675010753707596;9.636154594430804;2.230726264084901;5.9002562610276135;3.5506754949689903;HELO_1272;MerR family transcription regulator;COG0789;DNA-binding transcriptional regulator, MerR family;SoxR;HELO_RS01425;K;;phrB;;HELO_1272;MerR family transcription regulator;0.30887231672841153;-0.0343834708278985;0.04467723702215576;-0.16530005196073727;-0.4741723686891488
HELO_1273;69.30886783686078;83.60146215803807;142.81693691727185;139.02512291866867;121.86615432177803;147.22977705299573;6.843833772525407;9.490202718951167;8.756607631546496;4.885808645755921;11.090000262008225;14.815275996695933;HELO_1273;CbiX family protein;COG2138;Sirohydrochlorin ferrochelatase;SirB;HELO_RS01430;H;;;4.99.1.3;HELO_1273;CbiX family protein;-0.2669759341329758;-0.043601703784999835;-0.2707477374122371;-1.07605672323111;-0.8090807890981342
HELO_1274;169.35443272467117;83.72916463252899;207.7726039914052;271.1740389545109;264.5198215042341;198.6903505645656;5.631975155854667;6.894682529811499;25.122467843387916;6.486111578937654;34.98002871757767;5.659433822704939;HELO_1274;YfcH family protein;COG1090;NAD dependent epimerase/dehydratase family enzyme;YfcH;HELO_RS01435;R;;;;HELO_1274;YfcH family protein;1.007608937383547;0.06416778732155404;0.4110549441084759;-0.22922513285434043;-1.2368340702378875
HELO_1275;195.7093997367261;55.853708070274614;217.79099004116026;216.84811882949836;295.8649383563105;235.9496388104716;2.7422199589067464;3.7404116923747353;25.292445138578223;10.157840744512699;39.42959134100759;18.07515382978821;HELO_1275;cytidine deaminase domain protein;COG0590;tRNA(Arg) A34 adenosine deaminase TadA;TadA;HELO_RS01440;J;;;;HELO_1275;cytidine deaminase domain protein;1.7907395466032092;-0.11502713361824757;0.3252262500665859;-0.2685145635431052;-2.0592541101463144
HELO_1276;70.54980584505336;48.38752318827591;112.84811552423868;151.78863026491956;134.37391918911143;102.88039150405636;5.829763532418862;1.3225682536420735;11.141304835695905;11.76021139968344;5.223211577077738;8.20394735066899;HELO_1276;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS01445;E;;;;HELO_1276;LysE family transport protein;0.5348012335397652;0.1321870550380826;0.3820264631934842;-0.537903599138045;-1.0727048326778101
HELO_1277;127.21192403813545;192.46598588862682;174.18950591186456;112.73196269674031;83.0779023330141;171.504385499631;10.56509773070082;7.684204656168255;18.25374185303396;7.526605349660182;4.224642925537634;14.623128822645088;rapA;RNA polymerase-associated protein RapA;COG0553;Superfamily II DNA or RNA helicase, SNF2 family;HepA;HELO_RS01450;KL;rapA; RNA polymerase-associated protein RapA;3.6.4.-;rapA;RNA polymerase-associated protein RapA;-0.5935494995236636;0.022283318815526698;-1.0368344583931632;-0.4281025967899108;0.16544690273375284
HELO_1278;64.53621771721465;34.85764027549495;72.0787030035551;54.69221608810343;52.402732994465396;69.99991785621249;4.871045780941037;2.114627319369816;5.540220080875702;3.5703246721969233;4.028486475368118;3.0728949990009;resA;thiol:disulfide interchange protein ResA;COG0526;Thiol-disulfide isomerase or thioredoxin;TrxA;HELO_RS01455;O;resA; thiol:disulfide interchange protein ResA;;resA;thiol:disulfide interchange protein ResA;0.8700118629641596;0.041633673843951335;-0.41090377880157813;-0.11552494226216314;-0.9855368052263227
HELO_1279;121.82411622226876;71.46587765677641;394.30884989352444;394.45617162437594;345.1077745351602;364.9723242472281;20.391420814585285;11.121047210156663;45.00058610744386;23.96306333925648;32.312043908523705;32.7748700142308;HELO_1279;uncharacterized protein;;;;;;;;;HELO_1279;uncharacterized protein;0.7612201266138472;0.11124570116360388;-0.08051320360966763;-1.5751406941348263;-2.3363608207486735
HELO_1280;3.3643801076235866;1.880649688324711;1.9366718924221427;2.6202527060783196;2.94456552965773;2.3636175630041345;0.3513201398606107;0.21711380504526398;0.8109842932503214;0.17176208031666906;0.9558027638816783;0.17487911988369367;HELO_1280;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS01465;E;;;;HELO_1280;LysE family transport protein;0.5993825289022525;-0.19583159752540258;0.2298527215416275;0.3757630727906325;-0.22361945611162004
HELO_1281;13.214853833316951;4.660334005119505;6.7557648634707546;7.189009968495873;10.06482260116645;6.97212518967007;2.3785086574194483;0.09046490563313749;0.863823271431128;0.8089070296603902;1.1226816676883797;0.3780795713146451;HELO_1281;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS01470;K;;;;HELO_1281;AraC family transcription regulator;1.328440173067618;-0.03969530061724136;0.47294405032595055;0.8343629936105712;-0.4940771794570469
HELO_1282;15.791194620881447;10.88167711182483;7.269587658132892;8.786514308629554;12.204674619893813;9.145884536839047;3.847871461772566;0.623397633060341;0.14949288162967925;1.693332893571455;1.2724288087300135;1.1347180463330675;HELO_1282;uncharacterized protein;COG2068;CTP:molybdopterin cytidylyltransferase MocA;MocA;HELO_RS01475;H;;;2.7.7.76;HELO_1282;uncharacterized protein;0.49896638693178996;-0.29500734738050216;0.38015410470849886;0.7268102280597097;0.22784384112791978
HELO_1283;25.41107140529805;18.17514801642149;14.975149506605083;14.191706802820773;17.130337527175453;15.331169724882395;1.0808910434224601;0.45492459583161377;0.9936453592852049;1.2347469037232301;2.1136818559433994;2.4246380971871417;HELO_1283;DUF182 domain protein;COG1975;Molybdoenzyme maturation factor PaoD (Mo cofactor insertion), XdhC/CoxF family;XdhC;HELO_RS01480;O;;;;HELO_1283;DUF182 domain protein;0.4619051136175454;-0.03179869507813038;0.15077765550120414;0.6935146997503674;0.231609586132822
HELO_1284;18.767887118220855;13.97964384178905;15.646415844010521;15.388306015880806;20.77986506998846;15.702380618674786;1.3315984678135615;0.36891574145587414;0.6149285049706473;1.3183508296742432;1.2396678062351205;1.6967278108123576;HELO_1284;probable oxidoreductase cytochrome subunit;COG2010;Cytochrome c, mono- and diheme variants;CccA;HELO_RS01485;C;;;;HELO_1284;probable oxidoreductase cytochrome subunit;0.40015535501745036;-0.004842164469563315;0.3829412692091285;0.24310493036344472;-0.15705042465400565
HELO_1285;17.156682705462092;13.616889600248113;9.1181677430372;8.482107522317902;11.136498439859585;9.315334786260799;0.4181322761755059;1.1650102354571914;0.3637337315486384;0.8140854543301205;1.9996256324254964;1.562474844821745;HELO_1285;probable iron-sulfur protein (2Fe-2S);COG2080;Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family;CutS;HELO_RS01490;C;;;;HELO_1285;probable iron-sulfur protein (2Fe-2S);0.3128642950858356;-0.027842582909069602;0.2345615977294564;0.8157099959282172;0.5028457008423817
HELO_1286;25.50179017355156;21.46398114143227;26.438027785646664;29.95902010286522;34.40276330019429;26.43045668049076;1.3171907268737262;1.0767785203852653;0.0472168850701824;1.1330413233357708;5.54347435251994;1.892438169093677;HELO_1286;probable oxidoreductase%2C molybdopterin-containing;COG1529;Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit;CoxL;HELO_RS01495;C;;;;HELO_1286;probable oxidoreductase%2C molybdopterin-containing;0.23847618618983635;0.0003981446193774829;0.3680833303849367;-0.04968882553351772;-0.28816501172335407
HELO_1287;120.78563405821525;28.843402332188077;55.3358203620792;77.07864604210725;63.70201490307581;56.20255795549158;8.78529954769552;2.5346690153172076;1.9270623968040481;2.85870660077799;8.526705546034682;2.1565155336997903;dkgB;2%2C5-diketo-D-gluconate reductase;COG0656;Aldo/keto reductase, related to diketogulonate reductase;ARA1;HELO_RS01500;Q;dkgB; 2,5-diketo-D-gluconate reductase;1.1.1.346;dkgB;2%2C5-diketo-D-gluconate reductase;2.028860035462449;-0.0220271301621775;0.1777309781123897;1.0901923944128358;-0.9386676410496131
HELO_1288;1.1257126974288714;2.209129524911296;0.7053885067225192;0.7470243155783486;0.7058720344573644;0.7421782824510932;0.043727696898029196;0.2334114370058066;0.19266077201628817;0.12796596257473758;0.15387214735808985;0.10974386649798883;HELO_1288;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS01505;G;;dkgB;;HELO_1288;major facilitator superfamily transport protein;-0.5942353986380564;-0.030791828021125123;-0.030382839577443255;0.2870543544233115;0.8812897530613679
HELO_1289;29.555958429366882;21.951432329999125;27.397960788715192;27.261964471189568;21.10527685395046;23.90758024425024;2.0306356410081343;1.9935766734975817;0.8666367509237447;3.0280813212478526;1.5103593101104023;1.2304394565104757;HELO_1289;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS01510;K;;;;HELO_1289;LysR family transcription regulator;0.412869543119343;0.189202464398746;-0.17219406826595485;0.29486886236407983;-0.11800068075526315
HELO_1290;49.82919962379358;32.94590647108493;45.760113113006696;39.37060801052479;39.300534318606815;45.42679305278338;1.148906874409512;0.6010369558106371;6.5742717211753545;3.1441535735910544;1.1066686540384665;0.7598754654449141;HELO_1290;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS01515;K;;;;HELO_1290;LysR family transcription regulator;0.5824199030303054;0.010320790088140797;-0.20415866303752406;0.1306998840579654;-0.45172001897234004
HELO_1291;9.910055243786033;2.597632934957376;7.519158340188653;5.27409340922929;8.540279611798619;7.763644574417036;0.16528414312157494;0.19604592362723894;0.45895286973268967;0.4689001285821468;1.6018421063749675;0.32538980279897417;HELO_1291;beta alanine--pyruvate aminotransferase;COG0161;Adenosylmethionine-8-amino-7-oxononanoate aminotransferase;BioA;HELO_RS01520;H;;;2.6.1.18;HELO_1291;beta alanine--pyruvate aminotransferase;1.6005385052462258;-0.04082006957158013;0.122500575768691;0.31605552736208464;-1.2844829778841411
HELO_1292;18.567927776699847;8.53895697853112;15.485189798180548;10.106589314839269;17.72282632047855;16.031802899026143;0.24597838585645868;0.38213879266912404;2.3001974481165828;1.4146103421443452;1.9778964651374205;2.8384656805861566;mmsA2;methylmalonate-semialdehyde dehydrogenase (CoA-acylating);COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS01525;I;mmsA2; methylmalonate-semialdehyde dehydrogenase (CoA-acylating);1.2.1.18,1.2.1.27;mmsA2;methylmalonate-semialdehyde dehydrogenase (CoA-acylating);1.0365875532771631;-0.047060662155610444;0.1365670752671564;0.2002598247677616;-0.8363277285094015
HELO_1293;74.55628623315047;42.83059163339404;83.38640252056011;86.86602122355964;56.803880073316186;77.01774628479204;3.2024308881632138;2.2145465786208614;2.556151194699222;4.159030533265014;3.772059190122341;10.127459176359965;HELO_1293;uncharacterized protein;COG1112;Superfamily I DNA and/or RNA helicase;DNA2;HELO_RS01530;L;;mmsA2;;HELO_1293;uncharacterized protein;0.7856136389016974;0.11320822757969218;-0.4326359869482488;-0.046250531867407574;-0.831864170769105
HELO_1294;6.626271054405596;4.838180500963943;7.7417738585151765;7.139083804963366;8.132509843311961;7.7510040449880435;0.6524911683452214;0.4207667045993892;0.40606340985613437;0.7104926836478657;0.7101877694381414;0.5707369330623275;HELO_1294;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS01535;I;;;1.2.1.8;HELO_1294;aldehyde dehydrogenase;0.3854589927113161;-0.0015224963765274602;0.06156284975489301;-0.19847074529384656;-0.5839297380051627
HELO_1295;2.0609839157868577;1.3544515537732178;3.9764110828004426;3.7747460202331395;2.8644624514939907;3.2920062156355137;0.21545994511915026;0.1741739824023667;0.6119444592238259;0.39119217634404113;0.25420180609172444;0.3232916235769572;HELO_1295;NCS1 family transport protein;COG1457;Purine-cytosine permease or related protein;CodB;HELO_RS01540;F;;;;HELO_1295;NCS1 family transport protein;0.37860442669742134;0.21345350066882052;-0.15138441682900483;-0.4876567012758237;-0.8662611279732451
HELO_1296;2.5448015557809467;1.8298215262422282;5.267123471888208;4.63310118576782;5.228100550035812;5.7215521431709755;0.19698864339087807;0.4134645151791528;0.3685002860334043;0.221883770532982;0.43944929528272964;0.8418584064919918;aruI2;2-ketoarginine decarboxylase;;;;;;;;;aruI2;2-ketoarginine decarboxylase;0.3249937983989335;-0.10099100242026804;-0.11000218281538476;-0.9230895539962196;-1.2480833523951531
HELO_1297;1.1313840979432264;1.326880425860744;2.558924212521499;2.379325484817153;2.530157974149199;3.342357294592425;0.258388966041146;0.016824703870008992;0.13237896190596687;0.2711368023328012;0.16934063275863154;0.820413459720903;HELO_1297;uncharacterized protein;COG3314;Spore dipicolinate transporter SpoVV/YjiH/YlbJ, contains nucleoside recognition GATE domain;SpoVV;HELO_RS01550;DE;;aruI2;;HELO_1297;uncharacterized protein;-0.12660646973691514;-0.2870372266824657;-0.2987456922180036;-1.026687832144923;-0.900081362408008
HELO_1298;3.3248467278681075;3.082307201190306;3.7209137143309206;3.8140045081603424;2.654077189296183;3.567966595350354;0.6917620255167385;0.3711213493111275;0.8289814925261672;0.46361453466663827;0.43408822657820656;0.3808324476179987;gbuA;guanidinobutyrase;COG0010;Arginase/agmatinase family enzyme;SpeB;HELO_RS01555;E;gbuA; guanidinobutyrase;3.5.3.7;gbuA;guanidinobutyrase;0.08326425275458416;0.04751401398671451;-0.3220449905893661;-0.07890309590302103;-0.16216734865760518
HELO_1299;27.701878198914372;19.211695157662216;39.08354266974873;45.879451663826366;34.039965797234835;37.748069047617605;1.0360932198267716;0.7784915534086452;5.673838674608116;3.7799918949381213;6.015346192541714;3.6739698021499887;HELO_1299;PAS/sigma-54-interact/HTH domain transcription regulator;COG3829;RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains;RocR;HELO_RS01560;KT;;gbuA;;HELO_1299;PAS/sigma-54-interact/HTH domain transcription regulator;0.505954821515763;0.04888560504327266;-0.14512305090220856;-0.43297927027689376;-0.9389340917926567
HELO_1300;12.122368017942287;9.436714992242008;43.73158628921228;33.42658681895414;76.79821497526756;44.853926580010246;0.5485504795245333;0.49231151717844573;5.2498021068980485;2.206845610521936;3.0854313193452323;1.9253735419547862;HELO_1300;YcgA family transport protein;COG1288;Predicted membrane transporter YfcC, affects glyoxylate shunt;YfcC;HELO_RS01565;R;;;;HELO_1300;YcgA family transport protein;0.33036039934947414;-0.035751359821193596;0.7626917734859076;-1.8050171931993018;-2.135377592548776
HELO_1301;42.65366555538797;30.997476914378037;57.92965648877725;49.304712361798245;97.96738751525432;59.52692584318288;5.14938605234818;1.5099627544689838;0.42814068526766463;5.754469247985889;4.999767801964436;6.67984167511233;HELO_1301;DUF1028 family protein;COG3342;Uncharacterized conserved protein, Ntn-hydrolase superfamily;;HELO_RS01570;R;;;;HELO_1301;DUF1028 family protein;0.44814465134495407;-0.03858322207111353;0.7093761171197048;-0.471474277939107;-0.9196189292840611
HELO_1302;28.27947574253825;18.24136949562532;42.108326211627556;34.75210250946545;73.55587126961;43.52595245566644;1.5988234344507064;0.8308969506149673;3.469115460845217;1.7660819336132239;5.18028979377063;3.5812580264791145;HELO_1302;probable amidase (homolog to N-carbamoyl-L-amino acid hydrolase);COG0624;Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase;ArgE;HELO_RS01575;E;;;3.5.3.9;HELO_1302;probable amidase (homolog to N-carbamoyl-L-amino acid hydrolase);0.6056782360637962;-0.04667992501192142;0.7436754967357011;-0.6047567503973363;-1.2104349864611326
HELO_1303;40.16410528198033;53.73846941522882;65.62965754499805;66.9824496182839;62.97209324781257;68.70897735926935;1.623934476126097;4.542589030228306;4.895517826761691;4.443489165521976;3.9365081073185477;0.795348736116593;HELO_1303;GntR family transcription regulator;COG2186;DNA-binding transcriptional regulator, FadR family;FadR;HELO_RS01580;K;;;;HELO_1303;GntR family transcription regulator;-0.41116822606832226;-0.06517998459734287;-0.12390177239163247;-0.7599575943498627;-0.3487893682815404
HELO_1304;17.224066185350374;7.4919655569456625;25.004441456521146;20.996168289922313;40.79302714103964;28.237199501030574;0.6316772006636974;0.6849325631394309;3.6382617894964993;0.5963274374715266;2.603811424101058;2.1734794423545014;HELO_1304;PAS/sigma-54-interact/HTH domain transcription regulator;COG3829;RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains;RocR;HELO_RS01585;KT;;;;HELO_1304;PAS/sigma-54-interact/HTH domain transcription regulator;1.1016744668261271;-0.1690470777334916;0.5154571306531031;-0.6819602369983411;-1.7836347038244682
HELO_1305;3.4356330118732843;1.4591804873673944;5.35190431807549;4.945636078290986;7.179581268096162;5.647169021590163;0.2074018931490471;0.21856379022019295;0.7359115224705062;0.1726183922375011;0.5880304118224615;0.5589723534625858;HELO_1305;uncharacterized protein;;;;;;;;;HELO_1305;uncharacterized protein;0.8509623841344376;-0.06555085803739669;0.2992869514805174;-0.5836000315401688;-1.4345624156746064
HELO_1306;3.480486015042446;1.7199947231161727;2.6923175336158462;2.1369858640439294;3.753194483025162;2.165476175181252;0.48332322518374693;0.24478062823406624;0.30717393270332566;0.8442199915486808;0.47748819792310937;0.23594855673786475;HELO_1306;probable oxidoreductase (iron-containing alcohol dehydrogenase family);COG1454;Alcohol dehydrogenase, class IV;EutG;HELO_RS01595;C;;;1.1.1.-;HELO_1306;probable oxidoreductase (iron-containing alcohol dehydrogenase family);0.7200513826874675;0.22210409064762282;0.5864748953380323;0.5012326980667903;-0.21881868462067722
HELO_1307;1.2157519879857805;1.1351430330245982;3.4052362712458417;2.8635807957579793;6.1860553535447025;3.258486329408983;0.26593969393262995;0.3011860092045582;0.41992058393005793;0.2756745548039827;0.03899392809722357;0.09468035701738119;HELO_1307;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS01600;G;;;;HELO_1307;major facilitator superfamily transport protein;0.053463688599685755;0.04887868053794797;0.75485932988247;-0.9425443107683371;-0.9960079993680229
HELO_1308;27.384043425389162;15.802491687699765;35.02434461199933;42.462681032941624;38.407635488160786;34.10336179991429;2.8284907434541244;3.0932945472950832;7.194946900547967;2.606953641997293;13.563503676080806;11.341928769434384;HELO_1308;uncharacterized protein;;;;;;;;;HELO_1308;uncharacterized protein;0.7564049318813915;0.03736298176950115;0.16686598636929695;-0.3065290800695335;-1.062934011950925
HELO_1309;367.29277238383315;246.98260948315442;362.6667208953192;323.53036127431454;338.5064416054948;373.25086583077297;10.955253310562872;15.003900859343787;27.174557881252277;19.972360415024383;21.001701503036717;23.842658241701834;ispB;octaprenyl-diphosphate synthase;COG0142;Geranylgeranyl pyrophosphate synthase;IspA;HELO_RS01615;H;ispB; octaprenyl-diphosphate synthase;2.5.1.90;ispB;octaprenyl-diphosphate synthase;0.5706141342466644;-0.041388743010752904;-0.14056670634874102;-0.023152568835378418;-0.5937667030820428
HELO_1310;2074.4434918788274;2552.2970330877038;1460.3574189732542;1068.9041464309093;843.4087932825588;839.6948114728137;101.51873551030111;281.3629737926154;257.92429448281223;465.8143067277153;138.79954440354732;138.14570003617098;rplU;50S ribosomal protein L21;COG0261;Ribosomal protein L21;RplU;HELO_RS01620;J;rplU; 50S ribosomal protein L21;;rplU;50S ribosomal protein L21;-0.29894172856358914;0.7976550014842552;0.006359433093338751;1.3037655778622508;1.60270730642584
HELO_1311;4486.537406841544;3857.898239413216;637.8303546119305;466.8675148331699;457.8215768761457;480.2458962317099;414.73534536613846;267.3778546419194;114.64554037887693;58.894988451317715;47.70085035760002;126.98913483214791;rpmA;50S ribosomal protein L27;COG0211;Ribosomal protein L27;RpmA;HELO_RS01625;J;rpmA; 50S ribosomal protein L27;;rpmA;50S ribosomal protein L27;0.21773496490917843;0.4086586270262238;-0.06884100016145567;3.2210778214371114;3.003342856527933
HELO_1312;233.6101544499344;302.63025415344185;280.5446705993558;346.2286120762266;286.77353782925803;282.22279861163526;5.747984171673297;11.663703338847066;11.470579463686375;19.752549273894775;17.138636531682533;14.107697939550176;obgE;GTPase ObgE;COG0536;GTPase involved in cell partioning and DNA repair;Obg;HELO_RS01630;LD;obgE; GTPase ObgE;3.6.5.-;obgE;GTPase ObgE;-0.37205009234418984;-0.008573560689617565;0.022996532529528935;-0.2716719450786771;0.10037814726551275
HELO_1313;256.315433835252;351.8103895557226;246.6285142176997;293.00439905343956;214.07649010159176;231.62397460427428;13.144161342344242;24.91712883138811;8.217878286343845;14.02419129348787;3.6739110255263387;10.642250754037143;proB;glutamate 5-kinase;COG0263;Glutamate 5-kinase;ProB;HELO_RS01635;E;proB; glutamate 5-kinase;2.7.2.11;proB;glutamate 5-kinase;-0.4553550531587707;0.09017765828756641;-0.11314995782476966;0.14553820186145217;0.6008932550202228
HELO_1314;2639.8209242363846;2889.2689943807386;2218.2410624871295;1873.537612188701;1714.6623020965035;2047.7626651234223;118.59961992758686;300.63500206805844;265.24330311777624;91.68975215401379;118.34763317784704;253.08536314175333;rpsT;30S ribosomal protein S20;COG0268;Ribosomal protein S20;RpsT;HELO_RS01640;J;rpsT; 30S ribosomal protein S20;;rpsT;30S ribosomal protein S20;-0.13021729438304774;0.11531351926027078;-0.2559872561878951;0.3662336068816394;0.49645090126468716
HELO_1315;127.4158111652644;241.8466547850628;156.76127717485068;179.4547345098362;139.90020252707424;153.42087311351725;3.3846049451166746;17.05090923017118;7.45277881965145;14.760411799876726;4.515118620242928;9.088643642612615;murJ;probable lipid II flippase MurJ;COG0728;Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis);MurJ;HELO_RS01645;M;murJ; probable lipid II flippase MurJ;;murJ;probable lipid II flippase MurJ;-0.9192227684911352;0.03087536109439526;-0.13219408993816284;-0.26604493041788224;0.6531778380732529
HELO_1316;302.90429716151044;239.94739242931573;221.71685815741614;246.02363808945742;198.6968334513837;216.5984056762678;17.52900834963522;11.730464263849335;14.327683223546812;16.78287067208426;4.644159811889122;18.293539820838358;ribF;bifunctional riboflavin kinase / FMN adenylyltransferase;COG0196;FAD synthase;RibF;HELO_RS01650;H;ribF; bifunctional riboflavin kinase / FMN adenylyltransferase;2.7.1.26,2.7.7.2;ribF;bifunctional riboflavin kinase / FMN adenylyltransferase;0.3348988864083875;0.03354277836862529;-0.12385652966520944;0.48194908836589523;0.14705020195750773
HELO_1317;352.5956724934472;358.3172001834919;446.6367296991735;454.7556565099433;447.37871774363424;441.53473398549863;12.081919295313675;8.246366162142017;16.81680633867565;19.926118678222657;14.108183041141102;26.36298452793227;ileS;isoleucine--tRNA ligase;COG0060;Isoleucyl-tRNA synthetase;IleS;HELO_RS01655;J;ileS; isoleucine--tRNA ligase;6.1.1.5;ileS;isoleucine--tRNA ligase;-0.023157379167750847;0.016537722933149368;0.018927107446296887;-0.3236900766206201;-0.30053269745286926
HELO_1318;248.4178703764155;190.43652178076977;108.5569808804753;110.15613856949973;117.3495988292713;121.45172921903564;7.4651246819984545;5.642712125064446;6.700997302304122;9.971050505272217;8.36827518415013;14.119266019544428;lspA;lipoprotein signal peptidase;COG0597;Lipoprotein signal peptidase;LspA;HELO_RS01660;MU;lspA; lipoprotein signal peptidase;3.4.23.36;lspA;lipoprotein signal peptidase;0.3816987457431509;-0.1605317326680531;-0.04915833149925852;1.02635168831244;0.6446529425692891
HELO_1319;350.4877157816997;295.3100456032842;196.38853668192257;202.43804983184444;173.97868541933335;196.37055754314073;18.928153178186925;9.346828900414296;17.986766811005634;3.928341911760827;8.28358848347124;12.174715383919978;HELO_1319;FKBP-type peptidyl-prolyl cis-trans isomerase;COG1047;Peptidyl-prolyl cis-trans isomerase, FKBP type;SlpA;HELO_RS01665;O;;lspA;5.2.1.8;HELO_1319;FKBP-type peptidyl-prolyl cis-trans isomerase;0.24636673126261321;0.00013141389144610827;-0.17372759941924887;0.8325674751496273;0.586200743887014
HELO_1320;384.4802972391506;387.6122447681158;299.4508720435468;314.81283538454414;296.05266723056;289.0333331634938;13.429138266596814;19.83415285332812;10.856432759507738;8.46923447371052;22.167069563505898;8.521594568086138;ispH;4-hydroxy-3-methylbut-2-enyl diphosphate reductase;COG0761;4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH;IspH;HELO_RS01670;I;ispH; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase;1.17.7.4;ispH;4-hydroxy-3-methylbut-2-enyl diphosphate reductase;-0.011674236809529503;0.050910392345633326;0.03450002564605015;0.4104384057698507;0.4221126425793802
HELO_1321;48.52648769236391;56.793763449648374;46.19925944483151;65.78516961938011;48.0661482098263;47.456647413866925;4.3108146440268635;1.469105833216825;3.1118923643159304;4.906808683481047;2.761798747691737;2.3142956395920433;HELO_1321;GspG domain protein;COG4968;Type IV pilus assembly protein PilE;PilE;HELO_RS01675;NW;;ispH;;HELO_1321;GspG domain protein;-0.22271350737343631;-0.03793036810535799;0.018033429400683865;0.03150571987548645;0.25421922724892276
HELO_1322;40.98039952615361;38.09010938531895;24.874692405203778;32.133377541208176;22.096547520634005;24.924966592810318;2.201325129472902;2.687544056373593;3.645307539366328;1.2116535429651731;3.3591030070215298;4.82981829929448;HELO_1322;uncharacterized protein;;;;;;;;;HELO_1322;uncharacterized protein;0.10291227507246159;-0.0028004178143810066;-0.16666491672923822;0.695373766811719;0.5924614917392574
HELO_1323;43.47583325078582;35.0137261792184;19.28115801386342;23.31060090213437;15.687085829028666;16.46133464979896;5.219416267452725;1.2708787178238243;2.4213415536897465;1.358269603585818;2.372173159347081;0.8859021861081519;HELO_1323;uncharacterized protein;COG4966;Type IV pilus assembly protein PilW;PilW;HELO_RS01685;NW;;;;HELO_1323;uncharacterized protein;0.30447475805314106;0.21597619474315088;-0.06543180520324032;1.3488577995361606;1.0443830414830195
HELO_1324;31.99173190549998;29.208823567220076;21.509086307203063;33.38115883680718;23.003982178239085;19.501090286305317;1.6795154958862502;2.000566337086245;0.5744099999995795;3.100166688236714;1.0940708540052233;0.8689877644178409;HELO_1324;uncharacterized protein;;;;;;;;;HELO_1324;uncharacterized protein;0.12713451258284447;0.13480685885917332;0.2275731268530956;0.6864038773750023;0.5592693647921578
HELO_1325;2.143099208945826;2.2357584541883835;2.1556718907037786;2.891161668431677;1.503278909712096;1.9914215913451834;0.5445687090249819;0.396574589144785;0.708580131786414;0.3103542910488836;0.40169996710195677;0.3971389044491247;HELO_1325;GspH family protein;COG4970;Type IV pilus assembly protein FimT;FimT;HELO_RS01695;NW;;;;HELO_1325;GspH family protein;-0.04191610603232543;0.07711596093830386;-0.2570122069440437;0.07135656139025315;0.11327266742257858
HELO_1326;121.76896200117217;80.71343588124938;162.1367468098933;154.23218841771902;135.27317288699336;136.3254598549107;5.29077292719316;4.016756059177792;5.927279367460221;17.234277831501384;5.604768231945562;2.98099954855569;thiO;glycine oxidase ThiO;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS01700;E;thiO; glycine oxidase ThiO;1.4.3.19;thiO;glycine oxidase ThiO;0.5873006491748143;0.24848266504657435;-0.011097545778520512;-0.16165325300974676;-0.748953902184561
HELO_1327;75.75866122256583;56.597406032210664;178.66679408116102;162.655963931991;182.94412094839765;215.03058377233;5.345486265783373;9.655192507215396;4.849336578994114;6.365183420526583;5.673341611338514;10.450773180255124;HELO_1327;uncharacterized protein;;;;;;;;;HELO_1327;uncharacterized protein;0.4143257095107806;-0.2659117759643479;-0.23196800437369625;-1.4928341170745645;-1.907159826585345
HELO_1328;83.13061963261332;108.14516249408211;267.7340908480549;259.32343622430113;268.5687256115532;258.10108979522096;3.413249740077445;2.4805447719663993;17.71242994311449;8.626521151376686;12.604675812878048;15.014380834897182;nadE;NAD synthase (glutamine-hydrolyzing);COG0388;Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate;Nit2;HELO_RS01710;C;nadE; NAD synthase (glutamine-hydrolyzing);6.3.5.1;nadE;NAD synthase (glutamine-hydrolyzing);-0.3755453138971019;0.0526642655848768;0.05713804637275821;-1.622812208533091;-1.247266894635989
HELO_1329;486.6770432649439;248.50101258457502;407.10485033043255;358.6480056118947;420.06805045082046;431.029574906212;16.283872014274586;20.844604746740814;20.392245932533786;13.023918767509256;10.08565341300212;19.032951838119285;bamD;outer membrane protein assembly factor BamD;COG4105;Outer membrane protein assembly factor BamD, BamD/ComL family;BamD;HELO_RS01715;M;bamD; outer membrane protein assembly factor BamD;;bamD;outer membrane protein assembly factor BamD;0.9668803903969465;-0.08219021938880999;-0.03707666482224603;0.17479598452837486;-0.7920844058685717
HELO_1330;144.67765808745654;137.3055056256964;149.57957125550092;172.64334508472504;178.72405895116665;154.79741416521594;6.367289968338281;2.93102734248121;2.3786507582743277;4.83780885820408;6.669761472952856;6.082732536824002;rluD;23S rRNA pseudouridine(1911/1915/1917) synthase RluD;COG0564;Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific;RluA;HELO_RS01720;J;rluD; 23S rRNA pseudouridine(1911/1915/1917) synthase RluD;5.4.99.23;rluD;23S rRNA pseudouridine(1911/1915/1917) synthase RluD;0.07492104684326595;-0.049145232038936726;0.20611226108673897;-0.09689165372278907;-0.17181270056605502
HELO_1331;140.57815720315477;122.32180272614954;108.39042070571031;113.45650918196877;137.15809914276514;116.9612959571047;3.063511943556937;4.447491852461198;9.490847616700728;4.947793867685116;4.788641944175121;1.181642978240259;HELO_1331;laccase domain protein;COG1496;Copper oxidase (laccase) domain;YfiH;HELO_RS01725;P;;rluD;1.10.3.-;HELO_1331;laccase domain protein;0.19917081826606964;-0.10882717028186129;0.22800656123537166;0.2632851249214134;0.06411430665534379
HELO_1332;268.59339447857445;78.54317581133327;168.6319999162939;569.743548248261;247.9817098475762;169.36991481242046;28.6108596247549;3.7348013768238886;4.901922505041166;44.11333215042322;15.434425344178614;8.004165227581414;clpB;molecular chaperone ClpB;COG0542;ATP-dependent Clp protease, ATP-binding subunit ClpA;ClpA;HELO_RS01730;O;clpB; molecular chaperone ClpB;;clpB;molecular chaperone ClpB;1.7609750794254664;-0.006262246102970437;0.5473691698359247;0.6621145521111806;-1.0988605273142857
HELO_1333;878.5869215737175;295.44083184684723;819.6857915559225;695.8622620935503;551.7559145782039;801.9380642941684;69.41990052392089;10.340776583307486;39.202135139698726;21.59251266694999;16.199075288145128;41.45453259425485;ilvI;acetolactate synthase catalytic subunit;COG0028;Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme;IlvB;HELO_RS01735;EH;ilvI; acetolactate synthase catalytic subunit;2.2.1.6;ilvI;acetolactate synthase catalytic subunit;1.569081974601124;0.031541268475779205;-0.5386461506193516;0.13153744535347123;-1.4375445292476527
HELO_1334;568.1305394504071;259.49374346108374;342.8790820963323;282.6677633274117;219.74048638720114;325.38237009428525;74.51745005832834;23.75958667056814;8.465323306140062;10.439010330527598;16.266846116985846;26.280464858254703;ilvH;acetolactate synthase regulatory subunit;COG0440;Acetolactate synthase, small subunit;IlvH;HELO_RS01740;E;ilvH; acetolactate synthase regulatory subunit;2.2.1.6;ilvH;acetolactate synthase regulatory subunit;1.1275108740550266;0.07533822984764349;-0.5642118696090987;0.8021964656831067;-0.32531440837191994
HELO_1335;65.63980957296583;54.00087363206931;47.19209909525637;44.10650932789693;48.40573632078189;47.00087092922694;1.5522657231412182;1.1276660676399426;1.2300021587933543;4.767811563354686;3.311466560528955;3.9883781688129405;HELO_1335;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG0604;NADPH:quinone reductase or related Zn-dependent oxidoreductase;Qor;HELO_RS01745;CR;;ilvH;;HELO_1335;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);0.2769297435865594;0.0057360593018547235;0.04161797524861921;0.47332369575356026;0.19639395216700084
HELO_1336;22.53430620889606;19.423899944848447;18.987249164124933;15.540597763602952;20.88951476688582;18.304216707391408;0.2617111744426068;0.8359846215363025;1.329202868402183;1.0326557144692552;0.885083045761669;2.5732229007040552;ilvY;LysR family transcription regulator IlvY;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS01750;K;ilvY; LysR family transcription regulator IlvY;;ilvY;LysR family transcription regulator IlvY;0.20450694779879885;0.05016391197123671;0.18132395778794486;0.28584930669785447;0.08134235889905561
HELO_1337;6476.57795678196;1389.7547924832004;1635.397727326955;1015.9875152544058;1089.673890429953;1420.1216746716352;354.8332447501487;39.07282551212841;35.759175253582406;63.01958592535816;111.84466803258053;119.06443629334143;ilvC;ketol-acid reductoisomerase;COG0059;Ketol-acid reductoisomerase;IlvC;HELO_RS01755;EH;ilvC; ketol-acid reductoisomerase;1.1.1.86;ilvC;ketol-acid reductoisomerase;2.2195863960839475;0.20349335706110416;-0.38181027876153983;2.188424391525853;-0.03116200455809448
HELO_1338;435.42592165710863;209.6904412315845;242.15067832297586;202.6995800972137;212.32441490623629;233.06779445523964;33.77742406291837;6.807172421153087;9.799434545033334;11.192443000965753;10.247227818252139;6.785429559723443;pssA;CDP-diacylglycerol--serine O-phosphatidyltransferase;COG1183;Phosphatidylserine synthase;PssA;HELO_RS01760;I;pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase;2.7.8.8;pssA;CDP-diacylglycerol--serine O-phosphatidyltransferase;1.0506119312143927;0.05492416957461366;-0.13387735564543135;0.898810346812696;-0.15180158440169667
HELO_1339;2356.5568122680247;682.2883136983529;2476.0698526432825;1936.6436153723516;1725.2827507451022;1752.7404417504156;89.01078226732044;46.63276754837034;426.66557014542076;697.1379383323144;559.1657330598056;367.05168794008205;HELO_1339;uncharacterized protein;;;;;;;;;HELO_1339;uncharacterized protein;1.7867261796238587;0.4981993118558652;-0.02276645556916357;0.42685729642207804;-1.3598688832017807
HELO_1340;409.99226103270536;134.3404959416712;421.07491356437595;334.03523317751586;340.1056139087332;442.12856938842316;16.377460002659085;5.8267697717204125;23.37900525321459;11.173741971582515;8.804820309348912;44.80229353802977;HELO_1340;uncharacterized protein;COG4395;Predicted lipid-binding transport protein, Tim44 family;Tim44;HELO_RS01795;I;;;;HELO_1340;uncharacterized protein;1.6025176479936452;-0.07022625941591976;-0.3775068442776437;-0.10861411499307216;-1.7111317629867173
HELO_1341;39.41463207928035;25.463752608557257;42.706738372687646;47.07619068498988;40.0201152259565;33.15608580254673;1.5065864031310081;1.432118176886321;4.36717182729057;9.081137193775776;8.500526892414229;1.0794924023006367;HELO_1341;isochorismatase family hydrolase;COG1335;Nicotinamidase-related amidase;PncA;HELO_RS01800;HR;;;;HELO_1341;isochorismatase family hydrolase;0.6108600610073678;0.35571306524854585;0.26418888899003257;0.24273505854769528;-0.3681250024596725
HELO_1342;155.3992197903003;110.09644907914787;188.6353536747997;156.41370617559957;205.0834540926804;185.94536087845395;10.889009451603064;4.723277824683748;13.074980917243968;15.909193078672029;10.695649601983765;14.14812424074768;HELO_1342;UPF0246 family protein;COG3022;DNA-binding protein YaaA associated with the oxidative stress response;YaaA;HELO_RS01805;L;;;;HELO_1342;UPF0246 family protein;0.4934206103506389;0.020611280006807675;0.14061200867070145;-0.2573833549374527;-0.7508039652880916
HELO_1343;231.40700879474207;179.05212906033725;310.49347143582605;208.69330470025918;345.9481903779824;325.6055141150965;20.42690189008068;4.386573472189856;12.760222756385744;7.690034302050168;3.787880039427164;36.20120867093413;tas;aldo/keto reductase Tas;COG0667;Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family;PdxI;HELO_RS01810;HR;tas; aldo/keto reductase Tas;;tas;aldo/keto reductase Tas;0.3682389183038728;-0.06834722202855481;0.08717109358930308;-0.4908955709243097;-0.8591344892281825
HELO_1344;883.4719815286836;1050.9707079787295;792.0335601347116;731.3544240502455;756.5772820159867;800.7032044697963;36.58960859908489;81.70598622738878;13.504178917385152;76.88302739696499;43.27207475718451;46.35732553317167;HELO_1344;TPR domain protein;COG0790;TPR repeat;TPR;HELO_RS01815;R;;tas;;HELO_1344;TPR domain protein;-0.2502061867025791;-0.015686320636360662;-0.08167517242971378;0.1417482008627058;0.3919543875652849
HELO_1345;267.2724736502765;287.67170344965183;76.86642791369866;76.27123227576669;86.08100153146317;69.53933692993006;2.456336882028787;13.834890530732673;8.677748164294776;2.7855063144102647;4.69953288258252;9.874139207917567;HELO_1345;RNase H domain protein;;;;;;;;;HELO_1345;RNase H domain protein;-0.1057306636795996;0.14257343033094383;0.30392998578200814;1.9271991135083901;2.0329297771879897
HELO_1346;289.6614477838739;191.14321991120997;222.08079154282623;174.68351240164512;261.92457636408284;220.66853242790543;7.583385104941312;3.0667929199915176;8.169785635500547;7.169048856249126;12.559433133912972;17.8097615467559;HELO_1346;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG0604;NADPH:quinone reductase or related Zn-dependent oxidoreductase;Qor;HELO_RS01825;CR;;;;HELO_1346;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);0.5971576612065768;0.009162312160165165;0.24624501841608737;0.39093574768415973;-0.20622191352241703
HELO_1347;206.5306570126726;100.10671511511565;98.11414092014724;77.0369264185347;108.74240743774124;106.50751853200764;13.625078180157828;1.861336548152973;1.9221499851244417;3.98713517090407;0.16961204071698474;7.774471635890145;HELO_1347;probable cytokinin riboside 5'-monophosphate phosphoribohydrolase;COG1611;Nucleotide monophosphate nucleosidase PpnN/YdgH, Lonely Guy (LOG) family;PpnN;HELO_RS01830;F;;;;HELO_1347;probable cytokinin riboside 5'-monophosphate phosphoribohydrolase;1.0374456525524698;-0.11727474717612996;0.02968357177646741;0.9488869130376889;-0.08855873951478088
HELO_1348;278.63579125462803;138.77892706964505;65.85156631773079;57.59624497234896;58.26974723101721;68.26470754858276;10.881296265266451;6.639820924611663;2.433406102238409;1.9175865682145574;1.7674972430982112;8.306101107657062;HELO_1348;DUF501 family protein;COG1507;Uncharacterized conserved protein, DUF501 family;;HELO_RS01835;S;;;;HELO_1348;DUF501 family protein;1.0004021486705135;-0.051159080320673844;-0.22482453824221427;2.0133566783444214;1.012954529673908
HELO_1349;354.18509119289246;190.99923596282522;232.34451592878688;275.2712962135758;279.20119605428755;270.5613420301415;17.37573439438424;4.826194321322456;5.158012651170909;23.631524734672077;12.26929133711331;9.030907726595267;ybaK;Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK;COG2606;Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC;EbsC;HELO_RS01845;J;ybaK; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK;3.1.1.-;ybaK;Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK;0.8874704562566746;-0.21881655868722394;0.04518499388844788;0.3872929060714103;-0.5001775501852643
HELO_1350;95.05085780640597;76.76754867253528;82.70404296241072;73.29606404718503;75.46578408568574;94.83356567851773;3.64470212069696;5.987958537174324;5.068614623629961;5.051421214121013;4.755238034054737;2.5762404368128817;HELO_1350;thioesterase domain protein;COG0824;Acyl-CoA thioesterase FadM;FadM;HELO_RS01850;I;;ybaK;3.1.2.-;HELO_1350;thioesterase domain protein;0.3046302342965266;-0.19523374037818275;-0.3257167142054991;0.003267450308217512;-0.30136278398830907
HELO_1351;88.3947856985796;71.31460701322663;64.51168377643951;58.77981735844784;62.0115645956962;70.01860324586374;2.729025081286335;0.5555285501896757;6.314671031191291;4.253333704353973;3.7722376013597794;10.55090281408805;HELO_1351;uncharacterized protein;;;;;;;;;HELO_1351;uncharacterized protein;0.30590359272795364;-0.11644475737885873;-0.17258035387933912;0.3319936964978165;0.02609010376986287
HELO_1352;131.95303602322983;136.70104467992482;165.39150856991975;182.07524051618293;186.76181894906736;182.1612747729283;2.128717994265915;6.6663564041054535;8.150834921306064;12.47796735708345;6.294933395000267;2.836684555054951;HELO_1352;uncharacterized protein;;;;;;;;;HELO_1352;uncharacterized protein;-0.05062278268092246;-0.1385327005414183;0.03578921211534247;-0.4621977891296991;-0.41157500644877665
HELO_1353;243.43116797273717;69.7936514987138;187.19165752451534;177.6924609238358;193.92533721314945;198.00647436340128;7.609496865796886;2.7368370020296338;13.19357041567006;5.874618459151689;15.982322251273352;16.561906143246578;patB;cystathionine beta-lyase PatB;COG1168;Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities;MalY;HELO_RS01865;ER;patB; cystathionine beta-lyase PatB;4.4.1.13;patB;cystathionine beta-lyase PatB;1.7877363623024012;-0.08061269207393096;-0.029893737013013677;0.2966128908518266;-1.4911234714505746
HELO_1354;175.57298669951822;282.8633404952103;331.0316514728739;311.72250217975477;349.4090315261795;330.93723010905546;8.393712282367915;9.851542296803846;11.018728459234348;9.526612333718436;14.702122649313402;15.998954011323756;valS;valine--tRNA ligase;COG0525;Valyl-tRNA synthetase;ValS;HELO_RS01870;J;valS; valine--tRNA ligase;6.1.1.9;valS;valine--tRNA ligase;-0.6849318975130094;0.00041032415232677977;0.07812950849069367;-0.9106458044327157;-0.22571390691970628
HELO_1355;250.03306849038884;303.8912909999779;265.3101291479193;294.7314139039381;280.4802010069666;254.7168079615108;5.2868881290830325;3.729701512710174;22.478616973623435;23.7116868467509;9.902255784436445;22.629272108482724;holC;DNA polymerase 3 chi subunit;COG2927;DNA polymerase III, chi subunit;HolC;HELO_RS01875;L;holC; DNA polymerase 3 chi subunit;2.7.7.7;holC;DNA polymerase 3 chi subunit;-0.2804175190298981;0.05856031240186965;0.13848645804275783;-0.02666956796242026;0.25374795106747783
HELO_1356;243.80683294659363;258.32453348127325;260.9891077868099;252.4590479283451;293.92288179537104;274.01906595470524;9.158608492671343;14.212005571119665;6.776405953362483;3.3584414054037666;5.306751341747112;1.8132660279100137;ygfF;probable oxidoreductase YgfF (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS01880;I;ygfF; probable oxidoreductase YgfF (short-chain dehydrogenase family);;ygfF;probable oxidoreductase YgfF (short-chain dehydrogenase family);-0.08311487278122165;-0.07002480541630973;0.10080612094148123;-0.16788781179419487;-0.08477293901297323
HELO_1357;376.4248689725748;372.6007752617063;549.4660781285917;438.16973411218277;628.9291978843062;587.7984680679955;27.546063244084607;22.140798371711465;22.643470964829866;6.766943693022396;31.129580509595026;14.656848010787716;ilvE2;branched-chain amino acid aminotransferase;COG0115;Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase;IlvE;HELO_RS01885;EH;ilvE2; branched-chain amino acid aminotransferase;2.6.1.42;ilvE2;branched-chain amino acid aminotransferase;0.01469203816115261;-0.09712025578408934;0.09741576540818819;-0.6415844308464003;-0.6562764690075529
HELO_1358;396.4131539042698;762.7934570220463;1077.4598905857504;874.391779215524;1059.0793573128785;1085.208575077268;24.930257723108546;16.650631075556912;15.54581995273085;25.869201403072548;44.788731937076136;58.888302989367155;pepA;aminopeptidase PepA;COG0260;Leucyl aminopeptidase;PepB;HELO_RS01890;E;pepA; aminopeptidase PepA;3.4.11.1;pepA;aminopeptidase PepA;-0.9425429364037328;-0.01032863610750212;-0.03512888910875844;-1.4505896277945176;-0.5080466913907848
HELO_1359;83.85826451973799;54.99538473100961;46.502117439899926;45.98720018916401;47.68797397503207;42.921170580946466;6.991192193093314;1.712464288677043;4.186086095612733;5.803935868555339;4.527196443572621;5.29151287357266;lptF;lipopolysaccharide export system permease protein LptF;COG0795;Lipopolysaccharide export LptBFGC system, permease protein LptF;LptF;HELO_RS01895;MN;lptF; lipopolysaccharide export system permease protein LptF;;lptF;lipopolysaccharide export system permease protein LptF;0.5997472518161269;0.11307531864745535;0.14864896244429904;0.9501386682641826;0.3503914164480557
HELO_1360;87.64861378789988;65.92828093380638;55.89531817215131;56.690821953514785;62.684103279876716;53.70485253334662;3.1013974712313876;4.098333552226313;3.576121323685729;1.2480650660736987;3.6856832500078256;1.4274427133656766;lptG;lipopolysaccharide export system permease protein LptG;COG0795;Lipopolysaccharide export LptBFGC system, permease protein LptF;LptF;HELO_RS01900;MN;lptG; lipopolysaccharide export system permease protein LptG;;lptG;lipopolysaccharide export system permease protein LptG;0.4054821127842807;0.05664112891015538;0.2192644829205168;0.6964292602950932;0.2909471475108125
HELO_1361;76.62238869895457;42.90784761964101;26.043631161894925;28.713793002910364;33.28916674586549;23.93302504255159;7.26538308093782;1.2262878083846824;1.1992788465854853;2.2257811158413223;5.149152514711809;7.581823489010205;HELO_1361;RDD domain protein;COG1714;Uncharacterized membrane protein YckC, RDD family;YckC;HELO_RS01905;S;;lptG;;HELO_1361;RDD domain protein;0.8219940156227663;0.11723094508226417;0.45969491512866334;1.6384148993998577;0.8164208837770914
HELO_1362;142.47697698158882;41.27154144150645;199.64142446867467;95.59205346383875;114.05522662024543;214.80809892396178;28.838245654397856;7.469004810656671;128.16411530485632;5.567949086621153;8.330789107111261;181.43866825645492;bfd;bacterioferritin-associated ferredoxin;COG2906;Bacterioferritin-associated ferredoxin;Bfd;HELO_RS01910;P;bfd; bacterioferritin-associated ferredoxin;;bfd;bacterioferritin-associated ferredoxin;1.7630606269131173;-0.10512951201091525;-0.9074224853809811;-0.5889297542592926;-2.35199038117241
HELO_1363;1344.2473903479734;1437.0420827262642;1344.3912313076585;1077.1747318158507;1193.0612793085381;1233.9458198910158;74.60167070424187;80.02654196165612;298.88486243127954;264.7054180377895;227.85731499535075;287.15405331502785;bfr;bacterioferritin;COG2193;Bacterioferritin (cytochrome b1);Bfr;HELO_RS01915;P;bfr; bacterioferritin;1.16.3.1;bfr;bacterioferritin;-0.09623438718075761;0.12357801181469696;-0.04857087090709733;0.12342375948386142;0.21965814666461903
HELO_1364;99.3766732875672;61.82384820809053;48.29189594541348;33.327547809152854;43.733588977174;34.53682812653266;6.580600020979477;0.6796155714747572;6.574292096448091;6.945314978370001;8.510237698623358;6.308201343292194;HELO_1364;DUF1653 domain protein;COG4728;Uncharacterized conserved protein, DUF1653 family;;HELO_RS01920;S;;bfr;;HELO_1364;DUF1653 domain protein;0.6760398162289958;0.47203555537754305;0.33204359246007176;1.4980372146858763;0.8219973984568805
HELO_1365;132.82035625055354;66.9393576032225;98.31278726829713;87.11745214057062;101.09444290521942;101.66648671870564;7.468982051214632;3.7447881961210148;4.424457521618302;7.559580750715;2.241142614079108;15.056594361033829;tcdA;tRNA threonylcarbamoyladenosine dehydratase;COG1179;tRNA A37 threonylcarbamoyladenosine dehydratase;TcdA;HELO_RS01925;J;tcdA; tRNA threonylcarbamoyladenosine dehydratase;;tcdA;tRNA threonylcarbamoyladenosine dehydratase;0.9779781079574326;-0.047913928864404376;-0.008060980397846862;0.382332268502128;-0.5956458394553046
HELO_1366;157.58351276921493;82.57404675872492;117.33848857484348;113.7555209788563;110.37177793139413;119.80126208312676;4.867492547531945;9.06372089366741;3.029220055435804;4.903507173318054;10.86553342119109;13.627357593387222;truC;tRNA pseudouridine synthase TruC;COG0564;Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific;RluA;HELO_RS01930;J;truC; tRNA pseudouridine synthase TruC;5.4.99.26;truC;tRNA pseudouridine synthase TruC;0.9241158884323122;-0.029716153296516445;-0.11725183333344891;0.3926072607353239;-0.5315086276969883
HELO_1367;145.24788899133767;59.18790577393181;100.71127694768175;77.15609128892784;78.2246898737831;97.5806888080917;4.370643703954211;1.3148947934173192;3.0812451084853407;11.353877120109672;2.315104299352194;6.100198163907757;npdA1;NAD-dependent protein deacylase;COG0846;NAD-dependent protein deacetylase, SIR2 family;SIR2;HELO_RS01935;O;npdA1; NAD-dependent protein deacylase;2.3.1.286;npdA1;NAD-dependent protein deacylase;1.2808702758872208;0.04510267612997154;-0.3153549543502807;0.5690388336983361;-0.7118314421888847
HELO_1368;76.22084992733367;80.92851274064957;61.83234224979506;65.17429186522465;49.354186313442845;63.213682778454995;4.055486287677035;4.5999552039507705;2.35740803726784;3.9492209440644106;4.869929686811967;3.9077144513161257;HELO_1368;DTW domain protein;COG3148;tRNA U47 aminocarboxypropyltransferaseTapT/TuaA/ YfiP, DTW domain;TapT;HELO_RS01940;J;;npdA1;;HELO_1368;DTW domain protein;-0.08537519230794377;-0.03137338087049546;-0.3507690173593865;0.2661096909010361;0.35148488320897986
HELO_1369;48.06573319052837;39.33140058863941;29.67330974946553;33.12662513189721;26.899857255978493;30.48995637093886;0.6446604067199221;0.407111057472645;5.793292077163838;0.911544854210532;2.19814721774505;1.2768726050082428;HELO_1369;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS01950;K;;;;HELO_1369;LysR family transcription regulator;0.28281231144479957;-0.037907912161531776;-0.1746340178196073;0.6398240598992206;0.3570117484544211
HELO_1370;212.36287188559797;150.2403773356762;196.9482737015513;164.44178677368754;177.3155996678676;198.99527392610875;9.265066610338584;3.045686161816496;8.556715370708867;3.9110067722150013;5.975465867178889;4.896842513095744;HELO_1370;TraB family protein;COG1916;Pheromone shutdown protein TraB, contains GTxH motif (function unknown);;HELO_RS01955;S;;;;HELO_1370;TraB family protein;0.496465795071801;-0.014842422439389935;-0.1655329877244096;0.09334324077136014;-0.40312255430044086
HELO_1371;60.76875495183243;66.25029592054766;40.2024310173301;29.967423972547888;35.83740642646969;39.873954337489685;1.8125989928770767;1.987340865348337;3.836039893763263;0.3591663582057792;1.245690489400698;2.603885026924103;trkH;trk system potassium uptake protein TrkH;COG0168;Trk-type K+ transport system, membrane component;TrkG;HELO_RS01960;P;trkH; trk system potassium uptake protein TrkH;;trkH;trk system potassium uptake protein TrkH;-0.12266336479864837;0.011547638339262534;-0.15001033252224616;0.595695427980127;0.7183587927787753
HELO_1372;175.83133535563272;139.15653299296898;127.08655055269251;112.15678800372446;123.28790706970601;129.46507096796077;5.732109709417929;4.089578596072883;5.028395174705163;6.058560119082448;8.104009581635362;10.215375912229398;trkA;trk system peripheral membrane protein TrkA;COG0569;Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain;TrkA;HELO_RS01965;TP;trkA; trk system peripheral membrane protein TrkA;;trkA;trk system peripheral membrane protein TrkA;0.33533495681205494;-0.026544613361118685;-0.06997767768783003;0.43871033985752916;0.10337538304547422
HELO_1373;103.5622444475598;85.46248763960813;98.38350407189607;92.92114291105476;129.16562088127773;108.55429874640129;3.1229819117324666;8.58093643831332;11.483895735308884;13.011647299121547;4.590946682383202;16.24778718350339;HELO_1373;dodecin domain protein;COG3360;Flavin-binding protein dodecin;;HELO_RS01970;R;;trkA;;HELO_1373;dodecin domain protein;0.2742157641099139;-0.14056778006902526;0.24870236206628427;-0.06728408033949496;-0.34149984444940884
HELO_1374;122.39673251305005;99.85104553881204;135.8378251848639;148.45728755258145;152.39970130492372;141.5051405689748;3.171524911202072;4.278304195081379;7.054462812545172;9.201438930680819;4.863899069787353;2.7721834957499256;rsmB;16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;COG0144;16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family;RsmB;HELO_RS01975;J;rsmB; 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;2.1.1.176;rsmB;16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;0.2910781524355883;-0.05854688225775195;0.10628171131083874;-0.20770976924961726;-0.4987879216852056
HELO_1375;186.4917267525319;156.79602667160304;152.71193042469562;152.4432047916979;146.32629651489415;152.2868075214732;15.473593064111158;0.9754994112873785;6.289686312558022;6.608744553162323;5.3258203752695845;4.432124266462267;fmt;methionyl-tRNA formyltransferase;COG0223;Methionyl-tRNA formyltransferase;Fmt;HELO_RS01980;J;fmt; methionyl-tRNA formyltransferase;2.1.2.9;fmt;methionyl-tRNA formyltransferase;0.24876605822346498;0.00399560662942644;-0.0572185758202064;0.2905933985397873;0.04182734031632229
HELO_1376;330.14905411895285;261.2111218715713;350.3919423175657;317.845823275084;320.152768488507;360.4637041679013;12.26407618287829;19.099760226716015;20.283445229627223;8.595442611912452;37.554129053615405;5.224539767560199;def;peptide deformylase;COG0242;Peptide deformylase;Def;HELO_RS01985;J;def; peptide deformylase;3.5.1.88;def;peptide deformylase;0.33675185758439063;-0.04076967876539328;-0.1705910551942278;-0.1263700510248693;-0.46312190860925995
HELO_1377;103.56471851570541;24.37231906986435;78.92815601507715;112.19352425487182;101.21722172449732;73.66173984302988;2.9597769746793827;0.38575796602123175;6.8249348203549305;2.5245401852755096;11.108682520379892;0.4272494446535053;dprA;recombination mediator protein DprA;COG0758;Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake;Smf;HELO_RS01990;L;dprA; recombination mediator protein DprA;;dprA;recombination mediator protein DprA;2.0430688546441864;0.09833467771480642;0.45319725109365105;0.4859551165032663;-1.5571137381409201
HELO_1378;321.8805245827754;296.0070514688303;340.12974413136027;376.8834804929584;367.77361832056494;323.8497078376406;13.334871463581843;25.81532360306047;14.490577936278372;18.20810855170399;7.430494885808628;38.800593466491094;tsaC;threonylcarbamoyl-AMP synthase;COG0009;tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC;TsaC;HELO_RS01995;J;tsaC; threonylcarbamoyl-AMP synthase;2.7.7.87;tsaC;threonylcarbamoyl-AMP synthase;0.1205032399542958;0.07054814570991041;0.1829630429044542;-0.008771984158132184;-0.12927522411242798
HELO_1379;118.18584752284613;145.00722306780298;78.62408952016393;83.61595298995107;78.1496944806115;71.72703652904649;4.550259642909655;9.522861882221838;3.2409526595434714;7.305445756534205;0.9381575137986803;3.879779181325106;hemF;coproporphyrinogen-III oxidase%2C oxygen-dependent;COG0408;Coproporphyrinogen-III oxidase HemH, oxygen-dependent;HemF;HELO_RS02000;H;hemF; coproporphyrinogen-III oxidase, oxygen-dependent;1.3.3.3;hemF;coproporphyrinogen-III oxidase%2C oxygen-dependent;-0.292826805759379;0.13071317987250541;0.1220919907769451;0.7126492402515767;1.0054760460109557
HELO_1380;147.15687848754337;176.07942042736144;158.73617495724477;156.60772523820927;191.04316542178034;152.66769352373913;1.0054030479448437;4.099280937399005;7.260402436406248;10.627508316918492;6.558623812162721;7.3268830800864695;aroE;shikimate 5-dehydrogenase;COG0169;Shikimate 5-dehydrogenase;AroE;HELO_RS02005;E;aroE; shikimate 5-dehydrogenase;1.1.1.25;aroE;shikimate 5-dehydrogenase;-0.25727094874686074;0.05587718191313851;0.3216167305352293;-0.05268828258300218;0.20458266616385856
HELO_1381;197.20341282694548;58.05004869398862;142.49447405407184;144.0060907039759;132.71535777998005;134.94986990807502;16.16671274930758;4.606270752347595;1.2555073891239201;3.273675401869633;14.798940424910336;14.12456227228819;HELO_1381;peptidase M48 family protein;COG4783;Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains;BepA;HELO_RS02015;MO;;aroE;;HELO_1381;peptidase M48 family protein;1.7469716498162482;0.07792040921617982;-0.023909596197301042;0.5439070333977627;-1.2030646164184855
HELO_1382;216.7575536570848;118.28643612410649;248.99468947307108;204.00038266052286;190.76113358817562;217.1421251186533;9.667534948978435;9.259863980907442;6.31242680172998;6.619984341646558;26.13303550600326;3.9976540745108937;HELO_1382;DUF815 family protein;COG2607;Predicted ATPase, AAA+ superfamily;Atu1564;HELO_RS02020;R;;;;HELO_1382;DUF815 family protein;0.868292758707427;0.19662905498842598;-0.1859580511317791;-0.0025456292419416826;-0.8708383879493686
HELO_1383;368.1268747235078;339.89939403880095;357.6501621980135;320.2308560126036;347.44198963374373;367.8062550941922;12.309576169742584;2.777824474836262;10.03497742427598;9.780924130450872;20.118768345165375;11.991853019418409;der;ribosome maturation GTPase Der;COG1160;Double Era-like domain GTPase Der;Der;HELO_RS02025;J;der; ribosome maturation GTPase Der;;der;ribosome maturation GTPase Der;0.11477074350828609;-0.0402858414071563;-0.08194463563601317;0.001253653914268682;-0.1135170895940174
HELO_1384;397.5279436069563;374.18919736067556;539.7748295936641;446.3547654729926;511.11459050238255;543.5653685429999;26.196446861885484;6.77204170151159;13.474155103778557;21.084897276228727;9.38705779131022;25.177182707563087;bamB;outer membrane protein assembly factor BamB;COG1520;Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat;PQQ;HELO_RS02030;M;bamB; outer membrane protein assembly factor BamB;;bamB;outer membrane protein assembly factor BamB;0.08706259565672347;-0.010077234747965846;-0.08863857451658319;-0.45042435228405786;-0.5374869479407813
HELO_1385;350.46003936984226;366.20137862190836;520.7137860249105;441.3267697014175;485.62062354249815;546.9721733322243;6.015417953758711;23.622606633097845;13.849282024630046;38.44655499373859;3.7431685363236333;27.07915925324181;HELO_1385;DUF9976 family protein;COG2976;Putative negative regulator of RcsB-dependent stress response, UPF0070 family;YfgM;HELO_RS02035;T;;bamB;;HELO_1385;DUF9976 family protein;-0.06321080947941304;-0.070844076942981;-0.1713051686550795;-0.6407419675637218;-0.5775311580843088
HELO_1386;217.70152589465934;287.9990710533485;356.0035824293907;343.5559149629762;364.6557206354084;363.6467009545739;9.103925304954263;18.89650815907478;10.509960352743262;22.772953453986815;30.295966346013234;10.708898941479521;hisS;histidine--tRNA ligase;COG0124;Histidyl-tRNA synthetase;HisS;HELO_RS02040;J;hisS; histidine--tRNA ligase;6.1.1.21;hisS;histidine--tRNA ligase;-0.40210156919666407;-0.030560790380361524;0.003986591233863024;-0.737536055544175;-0.33543448634751094
HELO_1387;217.67984939490336;277.2921739028499;278.5141808535356;249.08258043180203;276.4183802386664;270.95641762761994;11.548965566528853;13.980217452546695;20.102198978190668;6.373207653221809;8.793704013070153;12.956234239408369;ispG;4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin);COG0821;4-hydroxy-3-methylbut-2-enyl diphosphate synthase IspG/GcpE;IspG;HELO_RS02045;I;ispG; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin);1.17.7.1,1.17.7.3;ispG;4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin);-0.3477800508888462;0.03954600759488969;0.028687905061302033;-0.314555183858384;0.033224867030462235
HELO_1388;332.8280282548349;270.1608261443988;326.3640329903933;331.25487345885057;353.64675092476335;340.40024000697366;5.310240778314115;10.906453757644284;15.271767944435505;15.13932217749275;22.203846338642308;17.132713380778856;HELO_1388;RodZ family protein;COG1426;Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains;RodZ;HELO_RS02050;D;;ispG;;HELO_1388;RodZ family protein;0.2999563173329065;-0.060568248876077035;0.05491865789633188;-0.03235898389863223;-0.33231530123153874
HELO_1389;346.4589703226523;293.7215167746729;265.06038270793783;271.6618468913269;295.7667327724207;267.57122875624117;5.676752774518323;12.886181268235289;18.823485459041514;7.096692902847823;10.002596577843795;19.359761924787794;HELO_1389;PilF family protein;COG3063;Type IV pilus assembly protein PilF/PilW;PilF;HELO_RS02055;NW;;;;HELO_1389;PilF family protein;0.2374902359689557;-0.013551057202864314;0.1440246151018858;0.3715378659352524;0.1340476299662967
HELO_1390;303.8047617314935;374.54179300644313;357.797529143271;320.2801241358124;423.9066662900775;367.49262897952076;16.73264529454474;14.730989038886243;30.645761275222387;35.88132099430323;45.44285972330678;29.8018015910146;rlmN;dual-specificity RNA methyltransferase RlmN;COG0820;Adenine C2-methylase RlmN of 23S rRNA A2503 and tRNA A37;RlmN;HELO_RS02060;J;rlmN; dual-specificity RNA methyltransferase RlmN;2.1.1.192;rlmN;dual-specificity RNA methyltransferase RlmN;-0.30108802908327625;-0.03846580595382143;0.20551021689582782;-0.27375032000801625;0.027337709075260008
HELO_1391;845.0115609157073;802.8169451179475;1616.6816305682414;1004.0035308851683;1556.1306331851194;1546.13179077387;38.771495116269;119.20191508194424;124.14583383344414;17.735688198168415;151.4150644086161;209.30272512399256;ndk;nucleoside diphosphate kinase;COG0105;Nucleoside diphosphate kinase;Ndk;HELO_RS02065;F;ndk; nucleoside diphosphate kinase;2.7.4.6;ndk;nucleoside diphosphate kinase;0.07381038728626521;0.06433160821869777;0.009293885811397118;-0.8708468131557972;-0.9446572004420624
HELO_1392;196.73432643037157;208.91272793085258;269.860574439868;271.5943781904386;236.70130301755088;251.43832007674905;20.887121467738435;9.262023957615705;6.77897903052582;5.095585010635865;12.272675854375846;18.98076838551101;iscA;iron-sulfur cluster assembly protein IscA;COG0316;Fe-S cluster assembly iron-binding protein IscA;IscA;HELO_RS02070;O;iscA; iron-sulfur cluster assembly protein IscA;;iscA;iron-sulfur cluster assembly protein IscA;-0.08622630336727966;0.10161948724485992;-0.08678111592116267;-0.3523675848540986;-0.2661412814868189
HELO_1393;164.68366323335775;227.22581494840438;218.65370023796982;200.4945686264435;166.51357827655647;213.6491305401213;18.06525171167134;8.855194489978357;12.013929974451194;9.254299672646535;4.711130530184075;15.523151829158342;iscS;cysteine desulfurase IscS;COG1104;Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family;NifS;HELO_RS02075;E;iscS; cysteine desulfurase IscS;2.8.1.7;iscS;cysteine desulfurase IscS;-0.4620306294275851;0.03325047395618341;-0.35770228705454876;-0.37354897227424644;0.08848165715333867
HELO_1394;179.68482911720278;179.79152360996125;157.79583086171974;153.8197813447014;135.7109271353925;172.02138699186366;8.427332652198622;22.349664084767042;13.177448220207957;5.183148684888306;9.124267999457278;21.800832235295623;iscR;IscR family transcription regulator IscR;COG1959;DNA-binding transcriptional regulator, IscR family;IscR;HELO_RS02080;K;iscR; IscR family transcription regulator IscR;;iscR;IscR family transcription regulator IscR;-0.0008516608010538107;-0.12377734346269076;-0.33982181851909576;0.06252499904185882;0.06337665984291263
HELO_1395;104.25537249893625;127.61391320688965;173.40745503339096;192.49282173398433;157.6429512223233;183.60199831535635;6.302234225208141;6.0918905626835675;13.199527961477969;3.270640039583692;1.8593971369186897;10.573231255128858;cysE;serine O-acetyltransferase;COG1045;Serine acetyltransferase;CysE;HELO_RS02085;E;cysE; serine O-acetyltransferase;2.3.1.30;cysE;serine O-acetyltransferase;-0.2891528451409666;-0.08195646090947761;-0.21863474896084156;-0.8105242962776202;-0.5213714511366536
HELO_1396;145.10550793006183;117.22758064357727;201.38314579315363;230.5669712983341;192.4441322545397;195.33435449848812;13.872905974036335;4.304806776988589;4.238148839482449;12.26930088441626;7.959339093866365;9.498631149752326;trmJ1;tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ;COG0565;tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase;TrmJ;HELO_RS02090;J;trmJ1; tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ;2.1.1.-;trmJ1;tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ;0.30544393338043196;0.04377651222334844;-0.021395668890881403;-0.42630207070787574;-0.7317460040883077
HELO_1397;315.7582832480426;364.7586043901195;322.9478177602803;307.1285781079876;318.02556400109324;315.9053586040658;7.001103655702427;7.259339925577298;6.287891764262104;6.293202993302547;32.333760979895004;25.941223980517425;HELO_1397;homolog to inositol monophosphatase;COG0483;Archaeal fructose-1,6-bisphosphatase or related enzyme, inositol monophosphatase family;SuhB;HELO_RS02095;G;;trmJ1;3.1.3.25;HELO_1397;homolog to inositol monophosphatase;-0.20750945742319082;0.03170938458739769;0.00961997926782665;-0.0006697082697115775;0.20683974915347925
HELO_1398;981.6249180300806;569.9639797382516;1199.901502557451;1192.142284525983;1106.4437380138688;1051.9815856578864;80.37203075109501;15.029763494800253;132.00795053244127;132.51706343846453;118.96287055190277;115.59510521443383;HELO_1398;uncharacterized protein;;;;;;;;;HELO_1398;uncharacterized protein;0.7832410908170235;0.18963761964060488;0.07275319971877714;-0.09976747755972148;-0.883008568376745
HELO_1399;304.1886109439681;230.87588159188522;339.5541971075542;247.89701336226895;382.9277721789991;368.2545409738275;4.839684287115607;11.314407820383366;29.792473844055017;22.620406359428806;35.456939415611146;9.668692355097864;secF;protein translocase subunit SecF;COG0341;Preprotein translocase subunit SecF;SecF;HELO_RS02105;U;secF; protein translocase subunit SecF;;secF;protein translocase subunit SecF;0.39634835768463805;-0.11673125034152321;0.05621926127505539;-0.2749145383460121;-0.6712628960306501
HELO_1400;391.06369291641096;290.94233606226885;410.1473677025301;280.08746322771486;442.1681199584418;459.84778553788396;12.844555324442075;11.177291600043024;13.625040300760555;19.13112139597859;19.105943997485408;6.949240140347441;secD;protein translocase subunit SecD;COG0342;Preprotein translocase subunit SecD;SecD;HELO_RS02110;U;secD; protein translocase subunit SecD;;secD;protein translocase subunit SecD;0.42540460852085715;-0.16463472599093087;-0.05643621587466541;-0.23320227113563696;-0.6586068796564941
HELO_1401;1037.9990115709568;609.9554985169821;1595.4653404202957;1082.4101033157094;1514.3018590038362;1601.9669362068091;41.73694098521901;45.285392917940854;28.707684359688255;42.47722099613559;40.8043385135606;39.22207540597896;yajC;protein translocase subunit YajC;COG1862;Protein translocase subunit YajC;YajC;HELO_RS02115;U;yajC; protein translocase subunit YajC;;yajC;protein translocase subunit YajC;0.766055077472231;-0.005863435821938268;-0.08113945034170555;-0.6255503861076583;-1.3916054635798893
HELO_1402;135.5504436191176;139.61245943695437;144.43325338822632;138.58003380567357;128.14287540243194;144.6104014467754;4.051643656939391;6.16651170973691;9.857403783411492;1.49574397626158;6.253587303862537;4.940567987004302;tgt;queuine tRNA-ribosyltransferase;COG0343;Queuine/archaeosine tRNA-ribosyltransferase;Tgt;HELO_RS02120;J;tgt; queuine tRNA-ribosyltransferase;2.4.2.29;tgt;queuine tRNA-ribosyltransferase;-0.04229043381513531;-0.0017562358971714431;-0.17314536127050495;-0.09267941476128705;-0.05038898094615174
HELO_1403;149.08913864175506;147.6527215983707;132.5672145142984;151.4636694896665;116.60140810903233;140.6604411404884;5.775279546191104;8.607386282715131;3.0990645361040796;2.0576750391777585;8.102699700143114;9.45865906351286;queA;S-adenosylmethionine:tRNA ribosyltransferase-isomerase;COG0809;S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase);QueA;HELO_RS02125;J;queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase;2.4.99.17;queA;S-adenosylmethionine:tRNA ribosyltransferase-isomerase;0.013873701620629397;-0.08487101355246374;-0.2685316055683371;0.08338263853299033;0.06950893691236093
HELO_1404;151.57944566506902;68.7878443910299;199.88616952040147;181.78877500500332;152.39795233703197;190.29734180039512;11.312964802344002;9.227027760260091;18.403384991942122;7.321592228345711;22.834136326708446;25.408154261356962;rnk;Rnk family transcription regulator Rnk;COG0782;Transcription elongation factor, GreA/GreB family;GreA;HELO_RS02135;K;rnk; Rnk family transcription regulator Rnk;;rnk;Rnk family transcription regulator Rnk;1.1285129508416087;0.0705614151179148;-0.31853760177908264;-0.3262562002180678;-1.4547691510596765
HELO_1405;211.23128342820243;97.25539623183751;139.49439053381354;157.562535428539;126.66589319196403;134.91283469522457;1.2239421319398858;4.490140531648381;6.3554406078396;7.702613341019811;10.502110826506666;10.200870904791406;HELO_1405;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS02140;E;;rnk;;HELO_1405;LysE family transport protein;1.1110287806877777;0.047830828691015626;-0.0903085502033596;0.6429556278589299;-0.46807315282884776
HELO_1406;37.44465755966775;26.14251757254282;45.54534084216698;47.97915998271761;45.021557222345145;47.23707029708594;2.5895657698445076;4.591248028191147;6.50404734550842;2.2368591892317267;3.4181988372402206;7.650154706786211;HELO_1406;YgjV family protein;;;;;;;;;HELO_1406;YgjV family protein;0.5022285863484779;-0.051505524892229815;-0.06783248650907847;-0.32735915827773354;-0.8295877446262114
HELO_1407;39.77525856536553;15.47727734827643;34.76851701268082;43.810063497505325;49.89006711750475;36.61795556354442;3.627021810220466;0.5488317469271714;3.4150764300597265;2.9573688954951316;3.4773801177771877;2.3042092019509433;aidB;homolog to adaptive response protein AidB;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS02150;I;aidB; homolog to adaptive response protein AidB;;aidB;homolog to adaptive response protein AidB;1.3072161494525592;-0.07273113988507163;0.43596264971763965;0.11627258110041883;-1.1909435683521403
HELO_1408;67.30041840331198;43.61876174525347;102.6019273108962;113.63251035897527;99.1499587170534;100.4355159445317;7.878617994404552;0.8477602740002088;7.870242203622239;6.76394475270212;3.9081014570910364;18.390519494855102;yfcD;NUDIX family hydrolase YfcD;COG1443;Isopentenyldiphosphate isomerase;Idi;HELO_RS02155;I;yfcD; NUDIX family hydrolase YfcD;;yfcD;NUDIX family hydrolase YfcD;0.6142439397548811;0.030487965524508276;-0.018401049809006587;-0.5705965547663245;-1.1848404945212057
HELO_1409;224.57298100581045;63.202084428933595;204.02789716863924;209.30664836004595;224.8954485020115;194.4258731376441;14.37578419611166;1.6692677081853118;24.506721272555517;14.321949440373366;27.96168407333705;19.850768321231428;HELO_1409;peroxiredoxin;COG0386;Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides;BtuE;HELO_RS02160;VI;;yfcD;1.11.1.9;HELO_1409;peroxiredoxin;1.8129022302044957;0.06919874016211303;0.20903371904287837;0.20697278939054886;-1.6059294408139468
HELO_1410;56.68340657636339;44.45119053716658;99.96159239545352;99.18865219318167;110.90025739416713;101.0375031932874;6.163034816672259;6.353969230161067;14.507434274479902;6.295596956422703;9.465737315489697;2.1531859320775584;HELO_1410;uncharacterized protein;;;;;;;;;HELO_1410;uncharacterized protein;0.34383828301191155;-0.015292932241977475;0.1331138523624391;-0.8228712298247212;-1.1667095128366327
HELO_1411;330.3213844307263;235.2115914863284;428.9116391530838;384.7355127874842;508.8826160985972;457.05276846376324;8.180901907278605;2.804906098310765;32.73755653035277;17.274073714248285;21.541669991772128;28.475362178105676;fabV;enoyl-(acyl-carrier-protein) reductase (NADH) FabV;COG3007;Trans-2-enoyl-CoA reductase;;HELO_RS02170;I;fabV; enoyl-(acyl-carrier-protein) reductase (NADH) FabV;1.3.1.9,1.3.1.44;fabV;enoyl-(acyl-carrier-protein) reductase (NADH) FabV;0.488151559010535;-0.09147363938305375;0.15465134282660387;-0.4672824867445051;-0.9554340457550401
HELO_1412;378.15274512739114;316.5454074510869;320.01003545466364;294.5557530105638;387.21997507675127;319.9829429829417;15.566176373006058;10.914562988752275;19.397527153078485;6.27942052257841;10.066010758580395;24.159300155738023;HELO_1412;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS02175;K;;fabV;;HELO_1412;PfpI/HTH domain protein (homolog to transcription regulator CdhR);0.2558162632807548;0.00012176511561534653;0.27437771628405727;0.24028253365679042;-0.015533729623964376
HELO_1413;34.426660944542085;42.48720662026566;26.903070278048688;27.976885455723203;33.448363783212415;28.80904215682679;2.7920303699585802;1.8329182138718854;3.5354754999928963;2.3896394577220854;2.9217365931392516;2.640885348408491;HELO_1413;isochorismatase family hydrolase;COG1335;Nicotinamidase-related amidase;PncA;HELO_RS02180;HR;;;;HELO_1413;isochorismatase family hydrolase;-0.29575554687558725;-0.09532614261448202;0.20868544143769174;0.2490854756069938;0.544841022482581
HELO_1414;18.574036130466826;15.887952000177918;11.169554857930548;13.213151291269961;14.926692567875733;11.475875255845098;1.4651557844830594;1.2678565612392545;1.67724348768999;0.3086801066755572;1.7723377009364611;1.3789600343518706;HELO_1414;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS02185;K;;;;HELO_1414;PfpI/HTH domain protein (homolog to transcription regulator CdhR);0.2129468844189093;-0.035864635001997325;0.35230566666186425;0.6498002350845367;0.43685335066562736
HELO_1415;112.07095039954811;85.65933863441654;169.04082041116936;174.78641979751205;210.25881727574543;163.21886289321336;1.66707915676405;1.0111169933364266;17.947444242698047;12.934648415440723;47.40516845108885;9.851753998094022;aruC;multifunctional acetylornithine/succinylornithine/succinyldiaminopimelate aminotransferase;COG4992;Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase;ArgD;HELO_RS02190;E;aruC; multifunctional acetylornithine/succinylornithine/succinyldiaminopimelate aminotransferase;2.6.1.11,2.6.1.17;aruC;multifunctional acetylornithine/succinylornithine/succinyldiaminopimelate aminotransferase;0.3838011958026897;0.05026127394217905;0.363391705321229;-0.5383915236378876;-0.9221927194405772
HELO_1416;115.7624427588147;114.34861153529562;150.45510956480993;157.9786827479693;151.56712131563404;161.9246882983608;3.6433343737514585;9.25974465560984;7.868080067350315;12.987989012306457;2.2744959386077404;4.853279398156986;aruF;arginine N-succinyltransferase subunit AruF;COG3138;Arginine/ornithine N-succinyltransferase beta subunit;AstA;HELO_RS02195;E;aruF; arginine N-succinyltransferase subunit AruF;2.3.1.109;aruF;arginine N-succinyltransferase subunit AruF;0.017575660305670482;-0.10531498441396803;-0.09476114439973937;-0.4806289363023808;-0.4982045966080513
HELO_1417;75.8839238216264;93.77284658103171;124.42510074815486;119.06779326049376;113.93658718904952;129.81970101951302;5.4365154194610845;2.1475625509624208;7.116809636819272;6.139975205312684;4.400980311109812;7.1353397984124385;aruG;arginine N-succinyltransferase subunit AruG;COG3138;Arginine/ornithine N-succinyltransferase beta subunit;AstA;HELO_RS02200;E;aruG; arginine N-succinyltransferase subunit AruG;2.3.1.109;aruG;arginine N-succinyltransferase subunit AruG;-0.30179180411754825;-0.06075372540386326;-0.18674170536411072;-0.7668259503627928;-0.46503414624524453
HELO_1418;107.06392004370848;99.4183337025034;178.90569816278625;198.70037747830762;203.7569175240758;196.9330982045776;2.0068868827590514;3.299223793419029;8.297582155773666;11.615020304995111;15.254458806507959;10.935394954771777;aruD;N-succinylglutamate 5-semialdehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS02205;I;aruD; N-succinylglutamate 5-semialdehyde dehydrogenase;1.2.1.71;aruD;N-succinylglutamate 5-semialdehyde dehydrogenase;0.10586223125126093;-0.1377719969274951;0.04889931401662562;-0.8731279566739207;-0.9789901879251817
HELO_1419;117.72387206320785;119.02876804408471;179.23757474492677;175.46886273195992;166.70446062688552;183.85524424393603;5.362369391470626;8.426334193476285;9.435776058360837;8.549799680460156;6.192291510455095;15.447679959449221;aruB;N-succinylarginine dihydrolase;COG3724;Succinylarginine dihydrolase;AstB;HELO_RS02210;E;aruB; N-succinylarginine dihydrolase;3.5.3.23;aruB;N-succinylarginine dihydrolase;-0.015770177074820424;-0.03649616650264598;-0.14047491017004532;-0.6387859226594399;-0.6230157455846195
HELO_1420;67.56441825259789;25.277840604004098;43.14992184643464;48.28688331906766;39.812946767633065;47.25457970467148;5.8025640624399655;0.5331848730197032;3.174540905159878;1.4239457811083502;1.0878430341319765;4.847478937104818;HELO_1420;DUF808 family protein;COG2354;Membrane protein MutK/YedI, may be involved in DNA repair;MutK;HELO_RS02215;L;;aruB;;HELO_1420;DUF808 family protein;1.3836133526308236;-0.1282549869166294;-0.24163899143962642;0.5067942079495973;-0.8768191446812263
HELO_1421;87.30470368523396;31.628469015507104;43.73648902741084;47.04483186084324;42.44992129899467;41.63695705813868;2.8750195624605253;3.8689304108500147;3.9658024729754295;0.3263010118654833;4.737213299170791;1.8125711726005522;HELO_1421;AFG1 family ATPase;COG1485;Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily;ZapE;HELO_RS02220;D;;;;HELO_1421;AFG1 family ATPase;1.436358992022246;0.0693475578454894;0.02724908530254666;1.0503858087000317;-0.3859731833222142
HELO_1422;124.56574053045802;46.81284070250343;166.39757014197446;157.49679857914322;168.77777308878703;165.3884634233407;10.28844009714295;2.459200737675583;4.02683628603836;4.146227555825478;21.027653385514377;10.358038418086188;HELO_1422;stomatin family protein;COG0330;Regulator of protease activity HflC, stomatin/prohibitin superfamily;HflC;HELO_RS02225;O;;;;HELO_1422;stomatin family protein;1.3929728635756167;0.008723179208717902;0.02909218957002313;-0.40611251569739615;-1.7990853792730128
HELO_1423;49.28203446847724;22.94567075921606;50.335775259414184;57.356587684328936;49.46383530072104;63.307344848855394;1.146319906934462;3.0807920682034293;3.8961715377639696;2.3746975312808423;0.26720314348063784;2.3870671370718552;HELO_1423;uncharacterized protein;;;;;;;;;HELO_1423;uncharacterized protein;1.0702781755296744;-0.3250189516111792;-0.34973366734010725;-0.3549405000253252;-1.4252186755549996
HELO_1424;77.03663644700084;46.78499201297097;70.9545662395438;77.00383720970217;66.4534164610198;65.06375331934564;2.5039564932053424;4.145561969244258;2.149538054555379;3.9915600891453002;1.5217440424807132;6.646953332332776;HELO_1424;UPF0126 family protein;COG2860;Uncharacterized membrane protein YeiH;YadS;HELO_RS02235;S;;;;HELO_1424;UPF0126 family protein;0.7075940184669509;0.12322730670944093;0.03003257971768214;0.24029265927044996;-0.46730135919650095
HELO_1425;26.754893735540538;15.945766167515012;15.636352232436435;19.53821876707688;17.27694373322338;16.010320320102757;0.5792648688842612;0.9429223270689141;0.6985380397912165;1.3412922358330068;0.3289884885626472;1.7694907470250576;HELO_1425;DUF3541 family protein;;;;;;;;;HELO_1425;DUF3541 family protein;0.7118173027527499;-0.0320711727246934;0.10361453485369765;0.7063318609577571;-0.005485441794992774
HELO_1426;25.00577660483302;11.688975116324338;17.938091362244876;23.420923425764517;17.257234184103524;18.724807545822145;0.5431262015630857;0.5883076924195838;2.5128248652840433;1.2714362671141806;0.7518576063689788;0.2554120113300962;HELO_1426;DUF4153 domain protein;;;;;;;;;HELO_1426;DUF4153 domain protein;1.0352565735076724;-0.058720284996893746;-0.1115429981570184;0.39882089747650173;-0.6364356760311707
HELO_1427;50.36980145666265;79.25901115246135;215.74856880342756;195.63289597914596;519.6840220436167;217.10214606868996;3.748454100721712;3.560464754821251;13.723887469434093;30.168800944123564;17.02182075582478;3.323830740990729;nhaD1;sodium/proton antiporter;COG1055;Na+/H+ antiporter NhaD or related arsenite permease;ArsB;HELO_RS02250;P;nhaD1; sodium/proton antiporter;;nhaD1;sodium/proton antiporter;-0.643742883502644;-0.008981498469670335;1.2554041703899879;-2.086011562975953;-1.442268679473309
HELO_1428;352.62247653427903;201.84444390930014;339.55486677765356;292.2195300926496;257.5032950147359;324.62009374027195;13.974089812570236;1.9767676469765498;35.163001832050654;3.958906904851266;12.23569917337201;6.736863262827379;HELO_1428;DUF3581 family protein;;;;;;;;;HELO_1428;DUF3581 family protein;0.801836190144118;0.06469751964868209;-0.33300705985695167;0.11902024668170519;-0.6828159434624128
HELO_1429;198.3503957969117;134.7548443600617;110.33176333050949;101.25390420513314;92.88144095286343;110.67780117601107;2.8149661791192346;4.087433050548349;6.5501995557965795;4.55337894252017;6.662870185760329;2.809207964736718;HELO_1429;MIT family transport protein;COG0598;Mg2+ and Co2+ transporter CorA;CorA;HELO_RS02260;P;;;;HELO_1429;MIT family transport protein;0.554302788740026;-0.004477184513868693;-0.25043055116327473;0.8359640279925911;0.28166123925256503
HELO_1430;49.592179887247674;25.89196630250618;47.137433954295965;94.50360322815312;80.56610273572839;45.3481134441703;3.3096846517086753;2.806359519680458;1.805158590115818;1.992669307782736;12.335449707961212;1.941120308434088;HELO_1430;uncharacterized protein;;;;;;;;;HELO_1430;uncharacterized protein;0.9117391556262433;0.054648622093849575;0.815459104608995;0.12640378599493562;-0.7853353696313077
HELO_1431;49.154352702781274;31.237591167226096;89.61369464907305;84.15769129106928;69.87769430912277;77.93859281045728;3.5989416509597807;2.1949255938987755;4.51966642950949;8.512717921059641;4.059301120907133;7.596374968467541;HELO_1431;MarR family transcription regulator;COG1846;DNA-binding transcriptional regulator, MarR family;MarR;HELO_RS02270;K;;;;HELO_1431;MarR family transcription regulator;0.6376309642763598;0.19899830303080357;-0.15539912844377657;-0.6543558892190511;-1.2919868534954109
HELO_1432;10.49796578777965;14.062238105348833;17.107110989358503;21.470422692509988;15.764870245309908;19.08898592970799;0.5279780447606227;0.32203505974159585;1.182927677445722;1.2648976050760679;1.2763439315886265;1.7766483636897035;HELO_1432;DMT superfamily transport protein;;;;;;;;;HELO_1432;DMT superfamily transport protein;-0.3895575135735432;-0.1498483592476454;-0.2609634230427549;-0.8050260970947813;-0.41546858352123817
HELO_1433;58.50348832723924;42.53990462283384;65.45762521638035;62.21847715628132;63.364334277626625;67.73749279968789;2.8236667837303493;1.8884338737901638;5.605313695828568;1.5809784502159687;0.6678031293656229;8.108904531456991;HELO_1433;nitroreductase family protein;COG0778;Nitroreductase;NfnB;HELO_RS02280;C;;;1.-.-.-,1.5.1.34;HELO_1433;nitroreductase family protein;0.45063600011979243;-0.04866248939066242;-0.09483575031921276;-0.2081229830364526;-0.658758983156245
HELO_1434;2.724417558673761;1.5425489933752872;1.684698749952789;3.0057032401535504;2.788641324131291;2.124111493548068;0.24856845022837143;0.15505342557810922;0.3573148955412527;0.2914942406595543;0.7772131455918472;1.079770264575612;aqpZ;aquaporin Z;COG0580;Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family);GlpF;HELO_RS02285;G;aqpZ; aquaporin Z;;aqpZ;aquaporin Z;0.5507392538060993;-0.2186857289362305;0.27823462297584123;0.2535688865961756;-0.29717036720992374
HELO_1435;103.26419895268309;25.07599756851549;64.54031418560321;83.57451478007069;65.64708329347914;61.25776604967469;2.419895713313924;2.202309657309502;6.207128115277907;0.6814247212031572;4.728226301395102;3.704754880279372;HELO_1435;GNAT family acetyltransferase;COG1670;Protein N-acetyltransferase, RimJ/RimL family;RimL;HELO_RS02290;JO;;aqpZ;;HELO_1435;GNAT family acetyltransferase;1.9994495158352477;0.07412877829987252;0.09828792882399995;0.7439181511079518;-1.2555313647272959
HELO_1436;180.85039083073403;75.42015087224827;88.9388362394863;141.38828368948091;95.98313069639765;87.87043281422973;12.389205105844264;3.379564705144473;6.407432365532141;8.042467976315535;14.355111209243642;6.435209490933383;HELO_1436;DUF925 family protein;COG3575;Uncharacterized conserved protein;;HELO_RS02295;S;;;;HELO_1436;DUF925 family protein;1.250727015373048;0.017240702064308167;0.1260303115259207;1.0329766069475763;-0.21775040842547178
HELO_1437;53.58915419426521;11.171397042183052;28.95885825539487;30.46846926573184;38.32394568012295;24.62617339078398;1.5678606426554496;1.3816800500077966;3.83859536453925;3.3217184134766296;4.002199891483942;1.2366389009728163;HELO_1437;uncharacterized protein;COG3823;Glutamine cyclotransferase;;HELO_RS02300;O;;;;HELO_1437;uncharacterized protein;2.165119572917318;0.22536457778150076;0.6177900205063667;1.0909962787520247;-1.0741232941652932
HELO_1438;30.859344495085292;5.2083038636833825;17.867152383475958;19.316854961768716;19.919560157357562;20.030199646693983;1.7838926250218263;0.9265508252197631;0.8642353765765599;2.1937662448622164;3.3452928849375625;0.9935242846549801;HELO_1438;uncharacterized protein;;;;;;;;;HELO_1438;uncharacterized protein;2.35944550709978;-0.15658585250021062;-0.007610027492131799;0.5992540376483193;-1.7601914694514607
HELO_1439;11.038071657944172;2.731983199005176;9.792573785462439;14.418843263770716;10.679231208489382;7.805797081497545;1.7065697389192331;0.418896941673417;0.9756951227695158;1.582036172858269;0.5320029670643571;0.14241437111943464;HELO_1439;DUF899 family protein;COG4312;Predicted dithiol-disulfide oxidoreductase, DUF899 family;;HELO_RS02310;R;;;;HELO_1439;DUF899 family protein;1.6895899132221928;0.2935134514089208;0.4074198065063932;0.45107880499777586;-1.238511108224417
HELO_1440;15.059015048713976;4.924573076209465;7.828051869119634;21.218523098743017;16.600526345211144;8.627687551855395;0.7631140742300203;0.9152681826812143;0.5777119825394202;0.3697632822871375;2.83683406812517;0.5653954428226499;HELO_1440;glyoxalase domain protein;COG3607;Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family;;HELO_RS02315;R;;;;HELO_1440;glyoxalase domain protein;1.438600307925284;-0.1250942164890625;0.8703573456408109;0.7381221826372326;-0.7004781252880514
HELO_1441;128.00643198671492;170.67159238012843;71.28467962224413;91.00767688440443;70.29009002236349;77.04360684141928;4.8077397755790106;15.839640962266493;1.1302991661346347;4.682442196161608;5.087145318795154;0.7764955149155491;arfB;peptidyl-tRNA hydrolase ArfB;COG1186;Protein chain release factor PrfB;PrfB;HELO_RS02320;J;arfB; peptidyl-tRNA hydrolase ArfB;;arfB;peptidyl-tRNA hydrolase ArfB;-0.4122083297645709;-0.1105905471284192;-0.13057891193813376;0.7250906373632136;1.1372989671277844
HELO_1442;58.719697402819996;51.24518935362136;44.586817076539795;55.13612117186609;38.71658306644114;50.51032624845083;1.3159262334935968;12.02349350244518;12.674631001044114;5.182127330546582;16.936572467713845;9.922062998504185;HELO_1442;DUF3820 family protein;COG3530;Uncharacterized conserved protein, DUF3820 family;;HELO_RS02325;S;;arfB;;HELO_1442;DUF3820 family protein;0.1929086529631867;-0.1762449955085419;-0.37512016867752607;0.21334517779861173;0.02043652483542502
HELO_1443;29.10162953559762;8.095723793076855;11.293692223992977;15.243245420045398;9.594506550466908;11.002795083194961;4.477182972532455;0.7448902990063873;0.6910815522918692;0.8462651074783466;0.6156794612809289;0.2359652112865427;ampR;LysR family transcription regulator AmpR;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02330;K;ampR; LysR family transcription regulator AmpR;;ampR;LysR family transcription regulator AmpR;1.7265812384715598;0.03454786793677789;-0.18005401008790756;1.3264711841962376;-0.4001100542753222
HELO_1444;78.33338883400697;14.608188201644083;39.56719975309479;47.42558707898087;53.63884072228874;35.3228929034265;1.899794574872076;0.7782297651507561;3.8509620965548015;2.1304416940848996;5.160667705145623;0.6163276916350917;blaA;beta-lactamase;COG2367;Beta-lactamase class A;PenP;HELO_RS02335;V;blaA; beta-lactamase;3.5.2.6;blaA;beta-lactamase;2.3456250979850437;0.15943461121840752;0.589047764823249;1.1270490676661957;-1.218576030318848
HELO_1445;71.677452239405;54.35927844778248;46.97410507839512;103.53983925641586;41.73998829373948;47.377735672923905;2.7904455324638433;5.148253863271551;3.4302536605734786;16.11662918799259;1.0848704976557455;3.2432290478141184;HELO_1445;YhfK family protein;COG0702;Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains;YbjT;HELO_RS02340;R;;blaA;;HELO_1445;YhfK family protein;0.3926827067154042;-0.012087351085214415;-0.17875673249210244;0.5871646003983111;0.19448189368290691
HELO_1446;71.59222794762152;74.27261025409605;60.68702266944204;130.76045225009352;49.958525014522955;56.69916827388266;10.095184696048797;2.259146524332549;7.366774732274692;25.865129436750024;6.188239842945977;11.777827244362028;HELO_1446;uncharacterized protein;;;;;;;;;HELO_1446;uncharacterized protein;-0.05230990613559161;0.09641649336625235;-0.17922700311026496;0.33126457227384876;0.38357447840944037
HELO_1447;24.603567308250266;13.09132286152959;18.573636861905232;20.55248837818733;20.258491455211153;19.474897419426725;1.2570737200337223;0.41210099838061837;1.0006852614273891;1.562256193784686;1.640864810225078;2.204152046389567;HELO_1447;DUF81 family protein;;;;;;;;;HELO_1447;DUF81 family protein;0.8615377779034366;-0.06494438436894079;0.05418300010688526;0.3224886089691159;-0.5390491689343206
HELO_1448;42.84882764396115;24.62813381394797;26.989852330072893;33.60783291245624;31.146114376840547;28.634384479340962;5.12903775696243;1.7645156191981712;3.5407506827154873;1.9587015369163976;0.9253900889426699;5.111635003532353;HELO_1448;YwhH family protein;COG2606;Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC;EbsC;HELO_RS02355;J;;;;HELO_1448;YwhH family protein;0.7748098423596508;-0.08236821682957807;0.11737227171747744;0.5652661785024105;-0.20954366385724033
HELO_1449;79.14561851081295;39.54665676180375;69.075792789071;111.06189189673502;75.67808041964685;78.0959551902098;2.380016352315422;3.447310328997828;3.7860110966122753;0.9943332067227147;8.052091209022512;3.823475428035585;HELO_1449;DUF1499 domain protein;COG4446;Uncharacterized conserved protein, DUF1499 family;;HELO_RS02360;S;;;;HELO_1449;DUF1499 domain protein;0.9830406884682255;-0.17468775902584266;-0.0447896994002388;0.01901973165962101;-0.9640209568086044
HELO_1450;131.33659627969595;36.80031602603041;100.22469737115908;146.0904646932179;75.08220837810319;100.50818129870208;1.997120773264196;1.1273521659152517;4.822567460983067;8.642658206347702;8.555385539528146;13.753922635133353;trkI;trk system potassium uptake protein TrkI;COG0168;Trk-type K+ transport system, membrane component;TrkG;HELO_RS02365;P;trkI; trk system potassium uptake protein TrkI;;trkI;trk system potassium uptake protein TrkI;1.8077418776495442;-0.004034679778423644;-0.4159649817243922;0.3826160691653513;-1.425125808484193
HELO_1451;2.7242229571796854;2.3822275161552358;2.239416813406048;2.380816506447451;2.337773917430731;1.9595528999958656;0.19850220871043336;0.42813807709939816;0.447049346523281;0.7919772700703365;0.18629716591799736;0.4426913790437821;HELO_1451;mandelate racemase domain protein;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS02370;MR;;trkI;;HELO_1451;mandelate racemase domain protein;0.138965734542144;0.13035486639249294;0.17350699352391086;0.3315602007607199;0.1925944662185759
HELO_1452;1.5596272336207164;1.6844750423765333;1.7400517158025746;0.8757511384526363;1.573199739327966;1.6070675037185012;0.21626116229560186;0.5952760681446512;0.3275179436342282;0.1513050156400453;0.03318934304986433;0.548256200457291;HELO_1452;probable oxidoreductase (iron-containing alcohol dehydrogenase family);COG1454;Alcohol dehydrogenase, class IV;EutG;HELO_RS02375;C;;;1.1.1.-;HELO_1452;probable oxidoreductase (iron-containing alcohol dehydrogenase family);-0.06870627078238822;0.07177518444205377;-0.018864490813606638;-0.026494217051017177;0.042212053731371046
HELO_1453;3.3886895001159765;2.22336714677015;3.4449624703548323;2.733842292870205;3.2485074925622914;3.773918003051341;0.35885406967263184;0.5384965554635889;0.8333035120454237;0.7802376570405997;0.10086137932792057;0.18976031724548392;puuC3;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS02380;I;puuC3; aldehyde dehydrogenase;1.2.1.99;puuC3;aldehyde dehydrogenase;0.44522168002799645;-0.10300254869845915;-0.16821767767115103;-0.12138358376176805;-0.5666052637897645
HELO_1454;38.77867157587102;31.533874589284903;48.21883526409874;53.469185852089005;46.133399318328;48.34869508116111;3.73663068718543;1.8217729638125577;5.900764452914291;2.966268343445739;3.31293550876062;0.9557008215270495;HELO_1454;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02385;K;;puuC3;;HELO_1454;LysR family transcription regulator;0.2900524486817124;-0.0038014186177868226;-0.06626220222158885;-0.311016838638567;-0.6010692873202794
HELO_1455;56.50376057276096;16.137089609368598;46.48771524455842;36.9790421116005;39.0359520639137;48.60758608167823;5.645812712591585;1.1571928174861956;5.574487945438939;4.356890637020632;2.147259206550626;2.028791545778258;HELO_1455;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02390;K;;;;HELO_1455;LysR family transcription regulator;1.7465341895892816;-0.06300641089694548;-0.3092646427940773;0.21309555003850456;-1.533438639550777
HELO_1456;5.4484452049339565;5.211929046393885;5.471763451980505;7.180409197840866;6.87593225618454;5.967267079902;0.3274553303915571;0.09695696414239204;0.9640401637575704;0.7738716717592679;0.21336276907182328;0.7271355464330952;HELO_1456;hydroxylase domain protein;;;;;;;;;HELO_1456;hydroxylase domain protein;0.05391000079158825;-0.10643399083867378;0.17685783420020185;-0.11164151601038697;-0.16555151680197522
HELO_1457;4.729389559418871;4.518651498066078;4.83699705110831;5.515320759878214;5.5879271327948095;5.884273526299091;0.39732783528197363;0.19659895279781095;0.26323573595315364;1.1464842907430022;0.677510301343187;0.3162494660928665;HELO_1457;peptidase M24 family protein;COG0006;Xaa-Pro aminopeptidase;PepP;HELO_RS02400;E;;;3.4.13.9;HELO_1457;peptidase M24 family protein;0.054065652077790016;-0.23807808038748668;-0.0634798218389121;-0.26492298521868207;-0.3189886372964721
HELO_1458;42.82806821127989;40.088493550428524;82.53861302556986;72.48422365415573;73.15009976815851;80.57705306852948;4.550860675263011;2.560449632073756;4.639116149549534;1.8457343586330044;5.63536916955719;8.551537133137098;HELO_1458;ABC-type transport system periplasmic substrate-binding protein;COG2113;ABC-type proline/glycine betaine transport system, periplasmic component;ProX;HELO_RS02405;E;;;;HELO_1458;ABC-type transport system periplasmic substrate-binding protein;0.0931206541174614;0.034279799516933274;-0.1377147576014215;-0.8963083001259742;-0.9894289542434356
HELO_1459;47.26152565889453;27.566386009500473;81.36559466470767;269.68958918891377;208.3397021990395;55.15672105594964;4.058127870018537;4.073663312907903;11.091803683775918;36.42685289571617;80.15117530647383;36.3507923172764;HELO_1459;OmpW family outer membrane protein;COG3047;Outer membrane protein OmpW;OmpW;HELO_RS02425;M;;;;HELO_1459;OmpW family outer membrane protein;0.7565549936247855;0.5525831276954856;1.8983153455733115;-0.2185851771280225;-0.975140170752808
HELO_1460;103.48126761538443;69.80319975806604;110.6791484971087;89.60383174412037;82.85805949922837;109.21981186299922;6.268057433428113;5.42252276290719;1.683590962585928;3.0905299057874536;6.3566481768755105;7.077011382355875;HELO_1460;probable flavin-dependent oxidoreductase;COG0778;Nitroreductase;NfnB;HELO_RS02430;C;;;1.-.-.-;HELO_1460;probable flavin-dependent oxidoreductase;0.5613578399779033;0.018976277094026273;-0.3943622184271698;-0.07713926416118522;-0.6384971041390886
HELO_1461;16.14169539773822;8.167262199426602;11.856025400963683;13.493574961949593;12.403581772293931;12.28314440295361;1.2669625234868147;0.39572831420570487;2.0409167603887775;2.1654198043460755;1.555794032786194;1.0175677879529454;HELO_1461;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02435;K;;;;HELO_1461;LysR family transcription regulator;0.9029469633781995;-0.04715201912241218;0.013021872671092893;0.36791310239083863;-0.5350338609873608
HELO_1462;2.669557952540876;5.891528909644812;3.3050165556258446;4.032472084769681;2.7442034356667953;3.457643542510922;0.29851058390875984;0.7533243408261711;0.6084226908504075;0.7313685556066869;0.32361100053406255;0.22040016648242153;HELO_1462;uncharacterized protein;COG0702;Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains;YbjT;HELO_RS02440;R;;;;HELO_1462;uncharacterized protein;-0.9092178037754923;-0.05026246970029691;-0.251622431728479;-0.28067497387311713;0.6285428299023752
HELO_1463;8.062807823671259;6.454665084261495;9.429938416927781;12.270739019348047;9.506636273057936;8.95636071483849;0.7555909238245828;0.9498345442994003;1.8040225980973;1.333512910851851;0.9934414912159087;1.0310434261939683;HELO_1463;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS02450;I;;;;HELO_1463;probable oxidoreductase (short-chain dehydrogenase family);0.28181455483987383;0.0670402349348107;0.07761045602520822;-0.13566040666716717;-0.417474961507041
HELO_1464;25.982252297913504;21.2062399778952;30.56082263525977;29.906295269870174;40.694200812032605;25.972737719145712;0.9620958395180363;1.5626865542082422;2.6445325974591065;1.1242797592906077;3.424985220647441;1.0766418012896748;HELO_1464;MerR family transcription regulator;COG0789;DNA-binding transcriptional regulator, MerR family;SoxR;HELO_RS02455;K;;;;HELO_1464;MerR family transcription regulator;0.28104564740268057;0.22663284798064698;0.6283447733743275;0.000508818025632074;-0.2805368293770485
HELO_1465;29.600609422274545;14.249740039782472;30.232595752376767;24.006848134268008;36.25588838769732;33.287827198126244;4.725646495152868;1.2825603353782842;5.583055897107188;0.5468264971153338;3.115565513923531;1.6490528082837594;HELO_1465;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS02460;K;;;;HELO_1465;TetR family transcription regulator;1.0047757355393419;-0.1346440070814543;0.11977198087683405;-0.164136099330765;-1.1689118348701069
HELO_1466;4.0803468820440765;6.762307627350469;4.9915610932041865;2.8864563534071803;4.106201094707324;6.028795835928849;0.8101019178143536;0.31136932077214813;0.2993817480461289;0.8126928578663956;0.8156318610363258;0.7450219001459877;HELO_1466;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS02465;G;;;;HELO_1466;major facilitator superfamily transport protein;-0.6115586031498763;-0.23034560559843165;-0.461027194118798;-0.46835054341701676;0.14320805973285955
HELO_1467;28.525770063065554;53.09119171760506;77.17390926880549;47.354814362252235;38.59041896778408;82.48386811773223;2.1679275818465236;11.094331735618676;9.169811319141093;1.911121075891049;1.5651174181999563;5.083619274329354;HELO_1467;uncharacterized protein;;;;;;;;;HELO_1467;uncharacterized protein;-0.8734189956641272;-0.09481026255819813;-1.076346112618566;-1.499522760353253;-0.6261037646891259
HELO_1468;39.70144950322686;23.844326519636752;32.725126493230206;33.51007591234124;27.51482714720768;30.470604023463963;2.208482236737079;1.6005684826789561;2.3920764623809516;2.2234584420411405;2.3949289974891244;1.5496753084220263;HELO_1468;YjiR family protein;COG1167;DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain;ARO8;HELO_RS02475;KE;;;;HELO_1468;YjiR family protein;0.7121637403737093;0.09981898539490786;-0.14229258159839642;0.3710753052716198;-0.3410884351020895
HELO_1469;21.8265424881097;12.39639283060744;35.81431640816381;42.024488458645656;35.97851652646435;29.80217226101207;1.0361093893921056;0.8233397510962527;1.4721501056850952;0.8597647849955045;2.5988073505238782;2.1509683892306604;HELO_1469;glyoxalase domain protein;COG3324;Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family;VOC;HELO_RS02485;R;;;;HELO_1469;glyoxalase domain protein;0.7688677658361356;0.25723481520944524;0.26365525139376356;-0.43231974502171244;-1.201187510857848
HELO_1470;5.276238512052516;3.4475234740009006;3.855239219047462;4.408847793838481;4.711438033439722;3.9192265050060713;0.3633515762997043;0.32579050132731247;0.2668475040894621;0.7058921738196205;0.3190442113335165;0.3108099848404651;HELO_1470;ABC-type transport system ATP-binding/permease protein;COG4618;ABC-type protease/lipase transport system, ATPase and permease components;ArpD;HELO_RS02490;U;;;;HELO_1470;ABC-type transport system ATP-binding/permease protein;0.49689795915695045;-0.018889105855908195;0.2154225497392379;0.35146869394930347;-0.14542926520764698
HELO_1471;3.7190969365612845;2.80129777940329;2.2144852939874884;2.3397254543567048;2.0139138438197133;2.1951674163526147;0.2227755948302734;0.35518118303510454;0.2238948007459713;0.2057562351221641;0.14886450826799;0.35476623662473133;HELO_1471;RND family transport protein MFP component;COG1566;Multidrug resistance efflux pump EmrA;EmrA;HELO_RS02495;V;;;;HELO_1471;RND family transport protein MFP component;0.31201876172203624;0.00869622486856425;-0.08425334923346184;0.5626192809963899;0.2506005192743537
HELO_1472;10.723096519254108;3.5342519397779384;4.427851047017846;6.044255182108287;4.962565904710633;3.800925231885073;0.5733655380397893;0.14718099448276767;0.38277574895550387;0.9805274627043464;1.0655193422332505;0.1440881677367483;HELO_1472;homolog to outer membrane protein TolC;COG1538;Outer membrane protein TolC;TolC;HELO_RS02500;M;;;;HELO_1472;homolog to outer membrane protein TolC;1.3704172312887128;0.17706866227130114;0.3126208393401728;1.2879693179692993;-0.08244791331941359
HELO_1473;6.270096450306113;1.926404586905238;4.94774645257283;4.628768729067378;4.722566402744131;4.321589466341146;0.4285153564795554;0.14686072845649628;0.27111439015401406;0.36354473750643973;0.7294608823781169;0.4886614698161508;HELO_1473;hydrolase domain protein;COG4222;Uncharacterized conserved protein, contains a phytase-like domain;;HELO_RS02505;S;;;;HELO_1473;hydrolase domain protein;1.3128452625872755;0.16048592978366294;0.10480508038649772;0.45011728605574763;-0.8627279765315279
HELO_1474;5.732333982047844;1.6150040244472503;4.933262996836652;4.613235104154385;4.0442618352617705;4.916477310349684;0.2861928052435049;0.05721315094634425;0.1648505391745913;0.328359435202942;0.6341952447861733;0.6905907730808805;HELO_1474;DUF3616 domain / hydrolase domain protein;COG2374;Predicted extracellular nuclease;;HELO_RS02510;R;;;;HELO_1474;DUF3616 domain / hydrolase domain protein;1.364293581849371;0.004087286678457147;-0.23009528182769623;0.1863683024075944;-1.1779252794417767
HELO_1476;62.52154609323487;35.58763060524402;46.66539714220182;30.643507071456025;26.801788685908207;48.37229874290761;3.3433681500926657;3.6955821849905566;5.594282117091882;5.36060261924476;1.725228844531822;4.603897266551035;HELO_1476;LacI family transcription regulator;COG1879;ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain;RbsB;HELO_RS02520;G;;;;HELO_1476;LacI family transcription regulator;0.7958900370562985;-0.05075950079624825;-0.8285241128873366;0.3635442100154549;-0.43234582704084357
HELO_1477;28.30242503258675;8.989112405458858;40.09771712141103;33.19845761910255;41.34045735241346;45.37714616554458;0.23887902273209588;0.24476777485596626;1.315019243320913;4.128967000571284;2.3261475420879534;8.775415955161494;HELO_1477;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS02525;G;;;;HELO_1477;TRAP transporter substrate-binding protein;1.5525916688217132;-0.17435578803500462;-0.13137719284657123;-0.662393980702273;-2.214985649523986
HELO_1478;10.527378826722474;4.133186357654456;11.407000036143778;10.697280865042508;11.67151849332273;12.129643718505555;0.8649382102546673;0.43518982562118186;0.7030557741526068;1.4090587258204115;1.1282416351065396;2.034837558546543;HELO_1478;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS02530;G;;;;HELO_1478;TRAP transporter small transmembrane protein;1.1671379576325736;-0.08167344864231518;-0.05123834787026116;-0.18776326774995322;-1.3549012253825268
HELO_1479;5.2024831581039175;2.191938001498777;4.416422346543722;3.3738929636014565;4.249388932787778;4.1825265032363825;0.287387212387751;0.26972989738409725;0.451876874646605;0.31557128877296114;0.48289283566117325;0.4500006052639204;HELO_1479;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS02535;G;;;;HELO_1479;TRAP transporter large transmembrane protein;0.9584132830114673;0.0636846484750273;0.018493903073670825;0.25919032346573534;-0.699222959545732
HELO_1480;19.419622105521842;6.717693638793698;13.004722501215914;12.530038202596636;18.767201511895877;14.553153833019175;1.1223052893297294;0.5510941175419006;1.0986771161231628;1.255165277751871;0.784404662081727;0.3141855427217784;HELO_1480;glyoxalase domain protein;;;;;;;;;HELO_1480;glyoxalase domain protein;1.4037144863424187;-0.15129375923981003;0.34590148344722804;0.39274901088901304;-1.0109654754534056
HELO_1481;25.7045869946987;6.58288689768149;12.09011240947621;11.496682713367477;19.246756823659595;13.148740626052941;1.7689626081634346;0.28175628329655306;0.2984339743825415;1.5375670271930497;1.1268635099928412;0.747157154984751;HELO_1481;ribulose-bisphosphate carboxylase domain protein;COG1850;Ribulose 1,5-bisphosphate carboxylase, large subunit, or a RuBisCO-like protein;RbcL;HELO_RS02545;G;;;4.1.1.39;HELO_1481;ribulose-bisphosphate carboxylase domain protein;1.8162684623883827;-0.11219615876802846;0.517017186947601;0.9164139270621017;-0.899854535326281
HELO_1482;33.55750702388423;13.911540263951727;14.75148444666921;13.532447337213476;22.12699255294436;14.744712440109344;1.0704670285103135;0.8032573154710165;3.1680688210120773;0.5059963352984037;2.833895660607963;1.0044302988514735;HELO_1482;DUF1537 domain protein;COG3395;D-threonate/D-erythronate kinase OtnK and related C4-acid sugar kinases, YgbK/DUF1537 family;OtnK;HELO_RS02550;G;;;2.7.1.231;HELO_1482;DUF1537 domain protein;1.2125698591175862;0.0006203885800215581;0.5547102608282599;1.1341317368642883;-0.07843812225329794
HELO_1483;36.90503097632577;12.499830294546612;18.633917400262618;17.51202934475944;20.086240145154033;17.783332613227884;1.4773086165493081;0.16840951112512706;1.0746897994549742;1.4360252188547822;1.1662296983346636;0.9123500983019027;HELO_1483;uncharacterized protein;;;;;;;;;HELO_1483;uncharacterized protein;1.489448072619107;0.06389499668886156;0.16684881897632842;1.01293628962038;-0.4765117829987271
HELO_1484;138.08224076171453;28.748490533321302;83.03719565468981;88.12294944482551;86.38894466627842;84.17534292796289;9.308655023481624;2.7267081497454395;12.940072022562898;9.905823287928833;9.471389721951;4.89284093038423;HELO_1484;nucleoside phosphorylase domain protein;COG0775;Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB;MtnN;HELO_RS02560;FH;;;3.2.2.9;HELO_1484;nucleoside phosphorylase domain protein;2.2250498440323945;-0.01940783116023148;0.0370149290821038;0.7074304597654528;-1.5176193842669417
HELO_1485;14.622447643557123;135.12146314727354;166.8941852891827;98.66284047004977;140.62013092765275;169.42929915987176;1.3814970204404233;16.426639531125918;18.55048345303834;25.95323162973582;8.388242378742051;36.181916378347395;HELO_1485;DUF427 family protein;COG2343;Uncharacterized conserved protein, DUF427 family;;HELO_RS02565;S;;;;HELO_1485;DUF427 family protein;-3.123202153560886;-0.02162111015644097;-0.26714702088031395;-3.447480965938275;-0.324278812377389
HELO_1486;24.874359020555016;17.748544533037357;44.00060984526192;50.262814919219515;51.07262828531597;45.54612805129546;1.392407414052512;2.4200753556841046;1.5106000644792126;2.8433228854665558;5.204709058921438;4.909445474907314;recD;RecBCD enzyme subunit RecD;COG0507;ATPase/5'-3' helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V);RecD;HELO_RS02575;L;recD; RecBCD enzyme subunit RecD;3.1.11.5;recD;RecBCD enzyme subunit RecD;0.4647445213110828;-0.04871660902638375;0.16186406445702328;-0.8471380384003222;-1.311882559711405
HELO_1487;32.31036203015625;23.488592964222452;52.08833253674851;62.411098422074055;57.819191505846554;54.61027437830594;1.1552910277946509;2.3667544433953984;3.0445801999109374;1.692616857472331;3.708425853616031;3.928975145171684;recB;RecBCD enzyme subunit RecB;COG1074;3'-5' helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V);RecB;HELO_RS02580;L;recB; RecBCD enzyme subunit RecB;3.1.11.5;recB;RecBCD enzyme subunit RecB;0.4438611502094121;-0.06695662710152295;0.08093549857510496;-0.7393804214688249;-1.183241571678237
HELO_1488;46.53361725540913;36.13376072685982;57.63515246334932;60.602006097377114;55.265535408396374;59.655182424482575;1.19776991903816;1.8814459658996088;3.1156110084894295;2.389710932826067;3.1944632985889885;5.9286622866200425;recC;RecBCD enzyme subunit RecC;COG1330;Scaffold subunit RecC of the DNA repair enzyme RecBCD (exonuclease V);RecC;HELO_RS02585;L;recC; RecBCD enzyme subunit RecC;3.1.11.5;recC;RecBCD enzyme subunit RecC;0.3562167615702503;-0.04886507890875791;-0.10837942346154872;-0.35168272225724984;-0.7078994838275001
HELO_1489;27.24207861120567;26.07192749370834;26.170767831907384;30.35776292558954;22.56918895989634;24.81605010225009;0.6133807380309341;0.9009762077012209;2.629166349246559;1.3896055103915348;1.4843299026906702;3.200766809474938;HELO_1489;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02590;K;;recC;;HELO_1489;LysR family transcription regulator;0.061048664946895315;0.07378705311822031;-0.13136616801895773;0.1295779917398292;0.06852932679293389
HELO_1490;5.732651605114316;1.5322981561308129;5.83002869263037;6.999623395333173;5.893732594722269;6.042603589305856;0.9410446206274002;0.46664272057577727;0.3646720550701873;0.13856526909194394;0.32572568927219386;0.39934371611327724;HELO_1490;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS02595;G;;;;HELO_1490;major facilitator superfamily transport protein;1.4107275319548171;-0.04421724006352745;-0.030823541089848305;-0.06493406774361299;-1.4756615996984301
HELO_1491;11.740829368365015;4.533498563993796;6.812029342714648;12.611997770091714;5.87991476072411;5.981289555206587;0.5338229727215607;0.49640845696830077;1.2649221357086267;1.060127917448808;1.7814875730306807;0.5990212702358443;HELO_1491;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS02605;I;;;;HELO_1491;probable oxidoreductase (short-chain dehydrogenase family);1.2031953728756575;0.16220381836470255;-0.021102859120063044;0.8678937384657042;-0.3353016344099533
HELO_1492;20.89271246046763;21.00070562975574;52.17386804789859;31.423806599726205;29.457912281247232;47.782864654625286;2.565962193096395;2.6811524917625307;4.885289598236232;3.9906610577427504;0.3520803223527059;2.4401946798662255;HELO_1492;HPP domain protein;COG3448;CBS-domain-containing membrane protein;;HELO_RS02615;T;;;;HELO_1492;HPP domain protein;-0.007099083686504137;0.1243429374133509;-0.6795574227904249;-1.1559237669283942;-1.14882468324189
HELO_1493;42.69217629491473;26.279473926110573;53.816485854975696;43.875079536651235;37.789252258360264;40.79642761997251;2.6568279130680033;3.6363073184978267;6.734682783141536;8.716210770938224;4.63645692242965;5.360032414884443;HELO_1493;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS02620;K;;;;HELO_1493;TetR family transcription regulator;0.679559144977036;0.39123020455880564;-0.10772267381225475;0.06399532873104352;-0.6155638162459924
HELO_1494;86.71162611754728;5.013990596115948;31.321739784930145;83.01076273584941;15.438201090336102;26.692179381424598;7.028222613071557;0.6335630621746084;7.531543296930476;4.921406087699611;6.322026504967474;17.137310698203848;HELO_1494;uncharacterized protein;;;;;;;;;HELO_1494;uncharacterized protein;3.866373566479868;0.2230262576112283;-0.7524261718788612;1.6632894849777795;-2.2030840815020887
HELO_1495;353.4724381077594;24.451394849804462;331.49971407562657;738.9264516972668;132.1165982938067;272.3745180110366;15.596236379849998;2.573921271853706;57.59069045566864;44.92424356731346;49.53979954798947;145.05589030175526;HELO_1495;uncharacterized protein;;;;;;;;;HELO_1495;uncharacterized protein;3.799856825834736;0.2824743283591715;-1.0381882996977687;0.3747946838817864;-3.4250621419529494
HELO_1496;32.336839538950535;8.573170325030569;39.72587160949359;61.476955336576395;35.877974593470846;33.58046937886499;1.8395204384976045;0.25974495224540867;6.92151993763375;4.138754402733824;5.1960379145118205;7.1410284654323695;HELO_1496;phosphoesterase domain protein;COG0622;Predicted phosphodiesterase, calcineurin family;YfcE;HELO_RS02635;R;;;;HELO_1496;phosphoesterase domain protein;1.8000486547627892;0.23598812387144008;0.09280197089448183;-0.05284011382090448;-1.8528887685836937
HELO_1497;20.60387265393334;12.972097398138866;22.546034219269206;19.936310417062387;20.410948829682727;23.839073405153226;1.1202544334222373;0.6289439017974082;2.064033643256366;0.24096900586867173;2.6742966127067986;1.567155799636246;arsB;arsenical pump membrane protein;COG1055;Na+/H+ antiporter NhaD or related arsenite permease;ArsB;HELO_RS02640;P;arsB; arsenical pump membrane protein;;arsB;arsenical pump membrane protein;0.6287413445575161;-0.07712726443892226;-0.2142626259738405;-0.20132140705399149;-0.8300627516115076
HELO_1498;36.33189646836238;30.73393013879299;44.426447948254584;35.30482921990453;43.83897065442816;45.36742812158226;1.5231724787765146;0.24916110197336397;0.2642072712543154;3.5976554334945807;4.172161260206194;1.4080671792336974;HELO_1498;ArsH family oxidoreductase;COG0431;NAD(P)H-dependent FMN reductase;SsuE;HELO_RS02645;C;;arsB;;HELO_1498;ArsH family oxidoreductase;0.23438259454998267;-0.029579205990510893;-0.04835854715615362;-0.3127029067385525;-0.5470855012885352
HELO_1499;17.437744290149592;10.080547583469059;27.605312362306638;17.018266733979157;25.37402399391766;27.592791123782206;3.555030810045281;2.539609741286285;0.789755012717556;1.8545820019255876;0.5571017067772888;3.455784529748511;HELO_1499;ArsR family transcription regulator;COG0640;DNA-binding transcriptional regulator, ArsR family;ArsR;HELO_RS02650;K;;;;HELO_1499;ArsR family transcription regulator;0.7346329855189855;0.0006316408381596972;-0.11653375151558265;-0.6329892930427103;-1.3676222785616958
HELO_1500;5.51738940975133;4.379453344869949;26.54370684042013;18.786691584483368;51.22022600824268;29.232455238048498;0.5388608728434844;0.30398459161498964;2.1522032511194498;1.1888890744332339;0.9576411617612807;4.872306979994409;matB;malonate--CoA ligase / methylmalonate--CoA ligase;COG0318;O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming);MenE/FadK;HELO_RS02655;I;matB; malonate--CoA ligase / methylmalonate--CoA ligase;6.2.1.-;matB;malonate--CoA ligase / methylmalonate--CoA ligase;0.2768346227345426;-0.13437541699289213;0.7885105537556312;-2.2137320451413935;-2.490566667875936
HELO_1501;2.8844877053662334;2.8250773444763593;19.240233111671046;13.332299792934473;27.107548874050693;21.228952165838827;0.005580785999980556;0.07211645771822661;1.3814223736700653;1.107542526655924;1.5116411463346209;3.256622813764912;HELO_1501;malonyl-CoA decarboxylase;;;;;;;;;HELO_1501;malonyl-CoA decarboxylase;0.022235425511571094;-0.13521403783511587;0.3385177047840653;-2.5166436932806304;-2.5388791187922015
HELO_1502;2.329437675449205;2.7610602223138243;16.134065737316607;10.743778556615338;18.5303264680806;17.821551205433934;0.6197149298112682;0.22691628434742592;1.8258433019233749;1.3489702653993745;3.1949040209560136;2.5687162640831027;HELO_1502;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS02665;G;;;;HELO_1502;TRAP transporter large transmembrane protein;-0.17586087282990537;-0.13551800605206132;0.053330530683131094;-2.4990350954078213;-2.323174222577916
HELO_1503;2.510052682527521;2.093304618629502;14.710861590379245;10.257741941662871;19.93793264490542;19.781337966148396;0.33715516243683;0.5120192088458163;0.9032674998743904;2.0847873443778506;3.5321553846594242;1.9392132422537853;HELO_1503;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS02670;G;;;;HELO_1503;TRAP transporter small transmembrane protein;0.18234377180017503;-0.4035262415394505;0.010830459121710767;-2.565723953079898;-2.748067724880073
HELO_1504;4.847147780660724;4.582676230257222;91.18464137154577;69.28900951508085;90.41112031090081;111.05430728653175;0.8574315107689797;0.38352175448332565;10.261237294494416;3.2423003629897487;13.181585663556099;28.6488017936431;HELO_1504;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS02675;G;;;;HELO_1504;TRAP transporter substrate-binding protein;0.06677616559838295;-0.28159979371554833;-0.2937565188066591;-4.260321241428251;-4.327097407026635
HELO_1505;24.93046435455824;17.247907907561515;55.46077939909642;57.49542661823219;64.73891031265534;48.92166234105639;1.60443481018241;0.5876530241098538;12.265669846821933;8.175550344778802;13.325235028327171;1.8918650215844515;HELO_1505;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS02680;K;;;;HELO_1505;GntR family transcription regulator;0.506916970874304;0.17758306896658382;0.3970815672304262;-0.9450179335420232;-1.4519349044163272
HELO_1506;41.71698299012962;33.80592778855273;38.407655280699565;46.9649529936573;55.140603639677465;36.23051152997318;3.3088765950274164;1.1592021402962744;2.2781777987840015;3.1146370743065193;2.382307355801982;2.0309951545724756;ogt;methylated-DNA--protein-cysteine methyltransferase;COG0350;DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase);AdaB;HELO_RS02685;L;ogt; methylated-DNA--protein-cysteine methyltransferase;2.1.1.63;ogt;methylated-DNA--protein-cysteine methyltransferase;0.2954767241156562;0.08199047471242249;0.592559137912879;0.19832431784719606;-0.09715240626846011
HELO_1507;27.539080686590044;11.02918060555674;23.20022537147469;28.711152720945467;30.839466869088554;23.724881502617603;1.3916379664032297;0.18751342571971122;0.8357368448413235;0.8121389736347515;2.295391791666966;2.7111345710657204;HELO_1507;AlkA/HTH domain protein;COG2169;Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains;AdaA;HELO_RS02690;L;;ogt;3.2.2.21;HELO_1507;AlkA/HTH domain protein;1.2464004893622525;-0.030943123617387158;0.3648525724178402;0.20697525614814705;-1.0394252332141054
HELO_1508;48.90233294103327;19.311427108591207;38.147402753687686;42.74161984385524;37.16369250672126;40.13470135573016;4.728934155697942;0.44444262479871155;2.055407806308052;0.13564382984204973;0.7283652317096914;3.1135774034265116;kynU;kynureninase;COG3844;Kynureninase;Bna5;HELO_RS02695;E;kynU; kynureninase;3.7.1.3;kynU;kynureninase;1.296815654415811;-0.07143937470680495;-0.1081552041095648;0.27875129397580256;-1.0180643604400084
HELO_1509;66.80024665510064;36.307438578562646;43.7944288230019;45.32400007959989;41.500154043453215;41.65084320542772;3.000883197941777;0.5309628794015477;5.258807110477158;3.587489988676211;7.4301052090857524;1.1404187474206302;kynA;tryptophan 2%2C3-dioxygenase;COG3483;Tryptophan 2,3-dioxygenase (vermilion);TDO2;HELO_RS02700;E;kynA; tryptophan 2,3-dioxygenase;1.13.11.11;kynA;tryptophan 2%2C3-dioxygenase;0.8618272095865018;0.07074504858652819;-0.005106193483698895;0.6687162580014547;-0.1931109515850471
HELO_1510;127.12704601603075;30.48076280204302;127.15578386703903;121.08977772479925;123.12437910269864;117.71680697294563;3.23971171855715;1.3267845411891788;7.621132754699906;9.262364514593022;17.119966818527356;15.147048992206233;HELO_1510;DUF2252 family protein;COG4320;Uncharacterized conserved protein, DUF2252 family;;HELO_RS02705;S;;kynA;;HELO_1510;DUF2252 family protein;2.0250326387512683;0.11037439651166636;0.06426230646889586;0.11005084806850185;-1.9149817906827664
HELO_1511;119.33584848674666;61.24507110384774;104.10776153098304;110.85919468394691;104.32095546495553;94.93156787179929;1.4061512965594476;2.164112086264526;5.751279074968642;0.8067449835773696;9.61331393796252;6.1940978328184055;HELO_1511;UPF0061 family protein;COG0397;Protein adenylyltransferase (AMPylase) SelO/YdiU (selenoprotein O);SelO;HELO_RS02710;O;;;2.7.7.-;HELO_1511;UPF0061 family protein;0.9510349841001808;0.13179166577734147;0.13471497340300775;0.32698894945155654;-0.6240460346486243
HELO_1512;15.289091433371892;6.746644825785317;9.05175830570027;15.37326545220691;15.747430895606874;8.44059714427947;1.8220076728789434;0.2559071125912676;1.1936456841594651;0.26785628867015515;4.449588334210313;1.250448110268641;HELO_1512;beta-lactamase domain protein;COG0491;Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II;GloB;HELO_RS02715;R;;;;HELO_1512;beta-lactamase domain protein;1.072262635528467;0.09049786508033586;0.8269897768485293;0.7869561139242891;-0.2853065216041779
HELO_1513;96.20283003610253;115.19357068768214;193.2194190355535;233.8421310814806;301.30947619170394;187.0075443320725;6.957583960309438;5.3745618539408735;1.5577622314296375;0.8090318890090978;22.145265130438517;18.82662867287994;katG;catalase / peroxidase KatG;COG0376;Catalase (peroxidase I);KatG;HELO_RS02720;P;katG; catalase / peroxidase KatG;1.11.1.21;katG;catalase / peroxidase KatG;-0.25746001937490437;0.04689690061905427;0.6852356471226653;-0.9517203320043608;-0.6942603126294564
HELO_1514;23.275845724413756;8.529515397638159;69.16517424019071;74.98032902685044;86.01917648609685;69.62754556117291;1.2361151183409653;1.7480027777988258;3.5213710102375;7.437432382744035;7.817231943386876;4.066602523258411;HELO_1514;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02725;K;;katG;;HELO_1514;LysR family transcription regulator;1.349046801220525;-0.009475819642909222;0.3011024028353164;-1.5407094037533815;-2.8897562049739065
HELO_1515;25.590715891720745;17.240749631247805;31.106165575144654;28.568031876144513;116.23849326041027;32.828812698809465;1.8514605342977213;0.1705137872993976;2.4090429409347207;0.8440842316250192;9.747845044202164;1.8267232643395743;mmsA1;methylmalonate-semialdehyde dehydrogenase (CoA-acylating);COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS02730;I;mmsA1; methylmalonate-semialdehyde dehydrogenase (CoA-acylating);1.2.1.18,1.2.1.27;mmsA1;methylmalonate-semialdehyde dehydrogenase (CoA-acylating);0.5437575983878586;-0.07540216833396762;1.7931218834786469;-0.34732992442071886;-0.8910875228085775
HELO_1516;11.721586430311143;7.429907723731148;10.20268387326633;9.244040854583229;9.90680261798248;12.989718504803449;1.460921348323255;0.8296434036147431;0.26844129338723777;0.6051566433250689;0.3272434385706806;0.8471411057367598;HELO_1516;SSS family transport protein;COG0591;Na+/proline symporter;PutP;HELO_RS02735;E;;mmsA1;;HELO_1516;SSS family transport protein;0.5936898472119179;-0.3205225273914092;-0.35913870289300664;-0.13708834208476262;-0.7307781892966805
HELO_1517;107.89866258252626;54.24679189883426;118.21553326117873;62.50940248983613;87.1852229284746;126.92838796405924;4.4159621084859255;4.482185672230611;6.117849868936118;4.2246912910523005;8.56774782666245;3.266550073401901;HELO_1517;RutC family protein;COG0251;Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family;RidA;HELO_RS02740;V;;;;HELO_1517;RutC family protein;0.9790236391505838;-0.10176421627448651;-0.5367276103529885;-0.23235020517031213;-1.211373844320896
HELO_1518;34.194792881457005;16.580785275155108;29.197606890158706;21.45872646888654;21.65535651331784;33.86944375133764;2.3479292434375596;1.2521107226785784;3.2757837163254107;0.3977016694945161;3.128799319677878;2.851326393167567;HELO_1518;N-acyl-D-amino-acid deacylase;COG3653;N-acyl-D-aspartate/D-glutamate deacylase;;HELO_RS02745;Q;;;3.5.1.81;HELO_1518;N-acyl-D-amino-acid deacylase;1.0013624836082125;-0.20752912704826798;-0.6221111561310284;0.013398645954215027;-0.9879638376539974
HELO_1519;39.731760170342845;13.96933585447168;23.832760380643354;15.562415804205074;13.739612558233715;26.4418945196156;2.140289750283568;0.3558125793084837;2.1500531118358035;1.04681371989806;0.5857164676601609;1.4633091559194893;HELO_1519;RpiR family transcription regulator;COG1737;DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains;RpiR;HELO_RS02750;K;;;;HELO_1519;RpiR family transcription regulator;1.4441439452204485;-0.14413544627401098;-0.8966814823878639;0.5697740748904598;-0.8743698703299887
HELO_1520;91.02268154474717;57.75481967409874;127.20789070051178;93.0709876559245;102.9408852028032;119.35955869851477;0.5744372794682198;4.225184744419308;10.39831299282932;0.40708681390496626;5.31900749735992;1.0897729716047198;HELO_1520;PLP barrel domain protein;COG3616;D-serine deaminase, pyridoxal phosphate-dependent;Dsd1;HELO_RS02755;E;;;4.3.1.18;HELO_1520;PLP barrel domain protein;0.6472822960420554;0.0911343348827085;-0.2115874713664816;-0.38728931975479153;-1.034571615796847
HELO_1521;327.3445244546667;215.4747500408671;278.44212954834893;272.44432042515604;266.5257705454291;282.55888731088004;5.237190689142767;8.62221000332243;2.526301180197179;4.158073675051949;4.742206512930554;5.870587353933909;HELO_1521;SSS family transport protein;COG0591;Na+/proline symporter;PutP;HELO_RS02760;E;;;;HELO_1521;SSS family transport protein;0.6010116402202854;-0.02109883174816396;-0.08397050212313495;0.21156202274083213;-0.3894496174794533
HELO_1522;113.802610968812;136.46692723614638;151.05557127008984;154.90202727882902;173.80809820064223;152.20696651978858;2.5968752202626866;1.7366145056586628;3.0265086169255806;3.5525744242298716;11.150975255853542;6.230753619345748;ilvD2;dihydroxy-acid dehydratase;COG0129;Dihydroxyacid dehydratase/phosphogluconate dehydratase;IlvD;HELO_RS02765;GE;ilvD2; dihydroxy-acid dehydratase;4.2.1.9;ilvD2;dihydroxy-acid dehydratase;-0.25992911286176135;-0.010883222725440511;0.19029012104087695;-0.41632644620822745;-0.1563973333464661
HELO_1523;267.2341534572079;280.2723184656348;308.9187352206316;309.76980554932805;404.3790845592816;309.36193056428823;10.285125360031765;32.9481850775383;38.06028996949406;13.895680745309122;28.032307659832497;10.39171923678778;HELO_1523;uncharacterized protein;;;;;;;;;HELO_1523;uncharacterized protein;-0.06847463318735691;-0.0020616339296601893;0.3853200498535454;-0.2104586623443936;-0.14198402915703667
HELO_1524;325.21867098914345;141.02685376388078;376.56170396908857;315.30357320112256;395.77529843578964;339.65815322002646;39.05896626900603;40.41418297833593;16.233725746696496;7.142332442079894;29.805397203429834;67.45299833913069;HELO_1524;HTH domain protein;COG5606;Antitoxin component of the Tad-Ata toxin-antitoxin system, contains XRE-type HTH domain;Ata;HELO_RS02775;V;;;;HELO_1524;HTH domain protein;1.1996756230032517;0.1483877035121921;0.21999747613264908;-0.062485379791839435;-1.2621610027950911
HELO_1525;60.99460576552848;39.60768630323614;137.47470788632185;76.63329393124096;92.82415159768662;148.63422801142784;1.388722393557569;0.6119563969238703;14.430470980837308;5.4491948211632355;7.035121350487361;11.27849453925492;HELO_1525;APC family transport protein;COG0531;Serine transporter YbeC, amino acid:H+ symporter family;PotE;HELO_RS02780;E;;;;HELO_1525;APC family transport protein;0.6103898606836005;-0.11181772645089705;-0.6734089768232012;-1.2712256263498567;-1.8816154870334572
HELO_1526;45.567118670971375;25.39904691922143;68.10135244792903;44.815211734959725;60.956486682463186;70.84085202368304;0.9995082777895623;1.4668280510072385;3.7745954705692037;5.376804677380277;6.148308136419841;2.7318108445314335;lhgO;L-2-hydroxyglutarate oxidase LhgO;COG0579;L-2-hydroxyglutarate oxidase LhgO;LhgO;HELO_RS02785;G;lhgO; L-2-hydroxyglutarate oxidase LhgO;1.1.5.13;lhgO;L-2-hydroxyglutarate oxidase LhgO;0.8188257733944031;-0.05609051312745539;-0.2135491236873639;-0.6254928418480104;-1.4443186152424135
HELO_1527;206.94746726980034;231.251767299019;629.2750946644109;612.8259002383138;888.4168312931464;727.2051158195403;2.6382843140332155;7.848328587690725;29.170231282458918;10.542695362787256;7.737274555524514;44.854087494923185;HELO_1527;TRAP transporter substrate-binding protein;COG2358;TRAP-type uncharacterized transport system, periplasmic component;Imp;HELO_RS02790;R;;lhgO;;HELO_1527;TRAP transporter substrate-binding protein;-0.15947046115739116;-0.20836322037549415;0.28851483035393954;-1.8081257625535425;-1.6486553013961514
HELO_1528;104.67815871616152;142.14328303214518;196.14940451897527;162.42531523686372;255.99833178675513;210.50295835256955;4.881170058747537;6.293415370936902;7.835939015411453;3.3149904761961775;10.946391207722373;2.9106735651067437;HELO_1528;DUF1850 family protein;;;;;;;;;HELO_1528;DUF1850 family protein;-0.43778273865690487;-0.10138849001989225;0.28108115183204596;-1.001000607762566;-0.5632178691056611
HELO_1529;57.2001564924521;96.64129994698756;140.54513994203808;111.87030245957055;173.34341832025848;145.78371616184276;2.987683759762142;5.6755163267232085;4.1018485263522155;6.823404928189597;3.907218739119708;7.948137135312822;HELO_1529;TRAP transporter 4TM/12TM fusion protein;COG4666;TRAP-type uncharacterized transport system, fused permease components;;HELO_RS02800;R;;;;HELO_1529;TRAP transporter 4TM/12TM fusion protein;-0.746468470207402;-0.05242971380032113;0.2482399737358909;-1.3345969904182162;-0.5881285202108142
HELO_1530;541.1982530535937;73.14714187144504;271.9793908038764;167.458716119054;206.92307628724828;226.87308549574036;46.13415537344851;1.8490784025557643;29.31156194296616;20.83608490208003;35.118038938844016;20.646678694355582;HELO_1530;uncharacterized protein;COG3126;Uncharacterized lipoprotein YbaY;YbaY;HELO_RS02805;S;;;;HELO_1530;uncharacterized protein;2.870357477149767;0.26056150040114723;-0.13218065112518484;1.2505899295309337;-1.6197675476188333
HELO_1531;134.59893814148543;142.83770090748422;326.3855371748995;243.57175630271334;284.2740543679854;314.75818569168524;0.6960124397506358;5.755150623276666;18.42442535431055;18.523964736837584;22.15753354420215;32.18527326704509;purE;N5-carboxyaminoimidazole ribonucleotide mutase;COG0041;Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase;PurE;HELO_RS02810;F;purE; N5-carboxyaminoimidazole ribonucleotide mutase;5.4.99.18;purE;N5-carboxyaminoimidazole ribonucleotide mutase;-0.08509598525294138;0.052170454842569214;-0.14647159482556837;-1.219474253864342;-1.1343782686114006
HELO_1532;95.30731972660153;143.03651035957992;301.7426672302012;224.36382446666357;294.13167226833815;303.31295216242586;2.974763024068876;11.187506746316894;15.21832406183686;15.34822024508461;3.1046865182037413;8.28805875008295;purK;N5-carboxyaminoimidazole ribonucleotide synthase;COG0026;Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase);PurK;HELO_RS02815;F;purK; N5-carboxyaminoimidazole ribonucleotide synthase;6.3.4.18;purK;N5-carboxyaminoimidazole ribonucleotide synthase;-0.5807171944927552;-0.007463722482579982;-0.044196986182596376;-1.6598383814010145;-1.0791211869082593
HELO_1533;12.435374826993062;1.8485772037719108;1.6099619639732718;2.3958681608777925;2.8763331778064427;1.2403564847204935;1.8041505325854432;0.09841023246735021;0.36728981059506743;0.10385744071816135;1.634351323524789;0.03892754692798396;HELO_1533;UPF0324 family protein;COG2855;Uncharacterized membrane protein YadS, UPF0324 family;YeiH;HELO_RS02820;S;;purK;;HELO_1533;UPF0324 family protein;2.2377231583614745;0.22030047030632183;0.79096426664896;2.584236354181493;0.34651319582001827
HELO_1534;24.764224459016592;8.410557590587917;12.642997816301412;27.576929681251944;16.487544696265562;11.250930465556962;3.814644686128515;1.3520736424395032;1.115718712634246;2.037333170415836;3.525152028025638;1.7347593961672543;HELO_1534;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02825;K;;;;HELO_1534;LysR family transcription regulator;1.4530170533180828;0.15526935990071733;0.5134364178190873;1.072477838958097;-0.38053921435998594
HELO_1535;25.95243768865957;10.238262426223224;18.545915205011166;22.788414809573514;22.765678733742774;19.150534142101403;1.0263833746733957;0.6360097382056467;1.8946390106792077;0.7615198848720762;1.7230951175442293;1.44594110595155;HELO_1535;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02830;K;;;;HELO_1535;LysR family transcription regulator;1.261996767736901;-0.04395094362150065;0.2380615231175378;0.4195976804877706;-0.8423990872491305
HELO_1536;8.351634663338066;2.109385042693529;6.04655179329719;30.83893511447356;9.650703994809533;6.996847332816376;0.32470006967493115;0.05278973129988309;0.2771337573179249;5.370415517148643;1.1966807305925655;0.6573084720836003;HELO_1536;APC family transport protein;COG0531;Serine transporter YbeC, amino acid:H+ symporter family;PotE;HELO_RS02835;E;;;;HELO_1536;APC family transport protein;1.588589289597894;-0.182513893614888;0.4134455425868375;0.22578722398618556;-1.3628020656117084
HELO_1537;18.253312555738166;5.872588042241868;18.5605837751861;36.12390707111191;23.869977215820644;16.5975736124177;0.8986415143174251;0.279058182615608;1.507528759555374;2.4460788145674974;3.7330674693386223;1.5360329238939296;HELO_1537;GlnA domain protein;COG0174;Glutamine synthetase;GlnA;HELO_RS02840;E;;;6.3.1.2;HELO_1537;GlnA domain protein;1.4861812957776488;0.1525729064117547;0.49902866487184294;0.12973016360708112;-1.3564511321705677
HELO_1538;24.020796917449413;11.653043325195902;31.01923553877519;51.35515927182936;42.05180169692826;33.00944004608366;1.1872851459820373;0.6019130777895272;2.8886436742236223;5.708757420535392;3.547768077136294;2.9672785306894394;HELO_1538;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS02845;I;;;;HELO_1538;aldehyde dehydrogenase;0.9836433149621215;-0.08699638892368444;0.3401383622142786;-0.4428075123911226;-1.4264508273532441
HELO_1539;28.309585107943082;14.220297671201903;27.32742813395799;52.416443162485045;40.08184557714827;27.19866737814225;1.0311644089916878;1.2619212929828274;0.8425854247684649;6.378111555747326;5.333932461224007;2.1617705038964807;HELO_1539;probable oxidoreductase (iron-containing alcohol dehydrogenase family);COG1454;Alcohol dehydrogenase, class IV;EutG;HELO_RS02850;C;;;;HELO_1539;probable oxidoreductase (iron-containing alcohol dehydrogenase family);0.9453759714438155;0.006572639538993563;0.542874010436698;0.05574556121094432;-0.8896304102328711
HELO_1540;21.893278749268102;8.670032083890144;21.995630815439128;46.57637479599243;27.04520809225815;18.527163576849727;0.40666235113748483;0.45022591872281703;1.6755409081066568;3.783078632834828;4.159100558377028;1.1712312050657818;HELO_1540;GATase domain protein;COG0518;GMP synthase, glutamine amidotransferase domain;GuaA1;HELO_RS02855;F;;;;HELO_1540;GATase domain protein;1.2433315173346835;0.23587736882171395;0.5222718822876553;0.22944169342403598;-1.0138898239106475
HELO_1541;82.74776360608386;15.329587185107718;27.257330404859957;19.80465944418712;22.694217847930076;22.77484867611051;8.504187377133446;1.4786262966143133;1.0738003315354412;1.2571574581801563;2.0282125571955874;0.8203836488315471;HELO_1541;TraX domain protein;;;;;;;;;HELO_1541;TraX domain protein;2.3585623455821363;0.24918901577580588;-0.004901120512894153;1.8166145068088744;-0.5419478387732619
HELO_1542;15.879905867798891;19.841126774916933;24.173917821505864;12.984265185621425;38.39824901515141;28.364474311916624;1.5270044693487281;0.6471324568135911;1.159087963496245;1.2028879854193077;2.494280467086698;4.648791024939412;HELO_1542;P-type transport ATPase;COG2217;Cation-transporting P-type ATPase;ZntA;HELO_RS02865;P;;;7.2.2.12,7.2.2.21;HELO_1542;P-type transport ATPase;-0.30412642023225;-0.22214204981182561;0.4240597024193802;-0.7987649519227995;-0.4946385316905495
HELO_1543;52.7884907872677;48.17824690147381;42.141138521634204;38.03121190044434;38.416449233264046;42.963214504695856;4.649218833134278;5.416399202232207;6.389895876219792;5.692522469548685;3.7331171349484937;2.9166578198849966;HELO_1543;MerR family transcription regulator;COG0789;DNA-binding transcriptional regulator, MerR family;SoxR;HELO_RS02870;K;;;;HELO_1543;MerR family transcription regulator;0.12927720306728663;-0.027232626572430974;-0.15749905779993068;0.2910006327507677;0.16172342968348108
HELO_1544;3.5607965478313433;4.320225490602142;5.858312568457827;6.081347437022231;5.049876601219503;6.976435598406105;0.5177600350352173;0.6441857737047938;0.41601203419835814;0.3996059362584366;1.4221940880887127;2.467145905861607;HELO_1544;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS02875;G;;;;HELO_1544;TRAP transporter substrate-binding protein;-0.22220157913534777;-0.21789054163486465;-0.39883848224634244;-0.8064583838387258;-0.584256804703378
HELO_1545;4.381495143480207;4.9000696706984606;2.104936392566487;2.3983270914139667;3.074971916255052;3.1498848639929524;0.3734868961437127;0.8010434087270212;1.1268439944301438;1.2046307201506148;2.028664205863053;1.454389339671494;HELO_1545;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS02880;G;;;;HELO_1545;TRAP transporter small transmembrane protein;-0.1327249374166386;-0.4185075964926672;-0.026281193662718305;0.37493574282887643;0.507660680245515
HELO_1546;2.555331789355654;1.5492914547742689;2.133856147578903;2.261960667075187;2.498669365006478;2.644785174886181;0.30208961702355885;0.1194543528921765;0.2139215723864847;0.16343654159993287;0.36145302367231275;0.6133338005119132;HELO_1546;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS02885;G;;;;HELO_1546;TRAP transporter large transmembrane protein;0.4798878779015112;-0.21789482627828982;-0.059027452118126655;-0.03584958324906884;-0.5157374611505801
HELO_1547;8.152361961831293;4.766859524498799;4.696303681531668;5.732086844779556;5.9098560363809485;5.071165434899046;0.9593548481077152;0.3539318448016974;0.5364370687603799;0.15766915130689133;0.5827067179399917;0.9037762153231533;HELO_1547;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS02890;K;;;;HELO_1547;PfpI/HTH domain protein (homolog to transcription regulator CdhR);0.6663582295413844;-0.09194742476764572;0.1866821669218517;0.5921706234850115;-0.07418760605637287
HELO_1548;331.0372022427301;435.7415818838856;837.5696392501463;818.2518322094505;745.6266719837935;864.6926132457335;22.19275494443686;14.382174245562036;65.78402357197169;36.17296669773049;41.882682452880836;117.31781122985818;HELO_1548;ABC-type transport system periplasmic substrate-binding protein;COG0834;ABC-type amino acid transport/signal transduction system, periplasmic component/domain;HisJ;HELO_RS02895;TE;;;;HELO_1548;ABC-type transport system periplasmic substrate-binding protein;-0.39543500208718996;-0.04592425157535729;-0.21346780193438875;-1.3825099557199003;-0.9870749536327104
HELO_1549;56.36840655159071;106.35591069446299;102.34666226300614;102.34232372044652;66.80931324021923;109.40062387214557;3.072889160932051;4.05977818608791;10.774721483364653;10.004290555238219;2.960199975939735;9.864868521311282;HELO_1549;ABC-type transport system permease protein;COG4160;ABC-type arginine/histidine transport system, permease component;ArtM;HELO_RS02900;E;;;;HELO_1549;ABC-type transport system permease protein;-0.9040732720701392;-0.095256529291329;-0.7031929863887907;-0.9444199730102572;-0.04034670094011794
HELO_1550;51.594855935867805;101.01070318375677;62.85676954149167;66.49741588485408;47.162669088429574;74.09104047632805;2.9456010439788525;2.303270395855767;4.758260136601159;9.871600906347403;3.112354968279435;4.6408588850611485;HELO_1550;ABC-type transport system permease protein;COG4215;ABC-type arginine transport system, permease component;ArtQ;HELO_RS02905;E;;;;HELO_1550;ABC-type transport system permease protein;-0.9557269227479468;-0.2338012120891042;-0.6407254362786556;-0.5137190791902144;0.44200784355773237
HELO_1551;75.76021505195284;167.065542740209;144.41943703570635;151.27757982176922;82.98104397757584;151.01084223168309;1.2656133709635884;6.031571683449325;15.011306841035719;4.727918079764398;2.8594104365837745;15.725986160711603;HELO_1551;ABC-type transport system ATP-binding protein;COG4598;ABC-type histidine transport system, ATPase component;HisP;HELO_RS02910;E;;;7.4.2.1;HELO_1551;ABC-type transport system ATP-binding protein;-1.1305933110702107;-0.06395411263550521;-0.8560386004189828;-0.9857435696003707;0.14484974146983998
HELO_1552;97.84967438757799;64.36549587615865;111.67897959347663;131.88656819953272;111.25613876684992;115.31837645796121;5.129645551404892;7.3456765863692315;12.704770385068317;12.304541571194425;29.233329906443988;4.307534685285978;aruE;succinylglutamate desuccinylase;COG2988;Succinylglutamate desuccinylase;AstE;HELO_RS02915;E;aruE; succinylglutamate desuccinylase;3.5.1.96;aruE;succinylglutamate desuccinylase;0.596706924527286;-0.045860633722003996;-0.051284696328846024;-0.2347709189294349;-0.8314778434567209
HELO_1553;60.23347444079646;4.821414279544056;38.79735930078598;38.89982107154021;96.76284415523857;39.2630732894358;6.912252763108055;1.255366384833771;2.9796583766602396;1.3232352803615925;1.9125763989296596;5.1540228587162575;gnl;gluconolactonase;COG3386;Sugar lactone lactonase YvrE;YvrE;HELO_RS02920;G;gnl; gluconolactonase;3.1.1.17;gnl;gluconolactonase;3.3948789497936653;-0.01678459180582248;1.279828959521522;0.6048632474913012;-2.790015702302364
HELO_1554;109.62910120984093;43.499021326284605;94.46107382529185;110.07377988633988;94.35833764855992;91.04368294830304;4.640872073503123;5.029195742091241;7.466519733055365;7.657365984114054;10.913969758743862;5.071620928321533;HELO_1554;probable S-adenosylmethionine-dependent methyltransferase;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS02925;H;;gnl;;HELO_1554;probable S-adenosylmethionine-dependent methyltransferase;1.313885427227615;0.05259385376830128;0.05104037463462863;0.2653403229021807;-1.0485451043254344
HELO_1555;20.610191689742884;11.713307365383606;33.35470614300869;25.90621202740589;22.082617244083917;34.977898018640744;1.767187657098442;1.1563311493184096;3.5668170188436616;0.8966548068380016;1.170819607490147;2.875398781338715;lhpA;4-hydroxyproline epimerase;COG3938;Proline racemase/hydroxyproline epimerase;PrdF;HELO_RS02930;E;lhpA; 4-hydroxyproline epimerase;5.1.1.8;lhpA;4-hydroxyproline epimerase;0.7653724733371647;-0.06660315785832704;-0.640304086109067;-0.735399031240414;-1.5007715045775787
HELO_1556;16.309034950158217;11.871533047017307;41.0997918750683;26.154005307496632;18.8475070587839;42.76251746478895;0.30920928204292025;0.2866805391429302;2.9000287793844226;0.3434783243280777;1.8924082191640803;6.686871811029907;HELO_1556;D-hydroxyproline dehydrogenase;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS02935;E;;lhpA;1.5.99.-;HELO_1556;D-hydroxyproline dehydrogenase;0.4273413966806032;-0.05588263121769632;-1.1407379230122583;-1.3381704416375442;-1.7655118383181474
HELO_1557;9.869166846830538;9.376001875140428;51.63994922732605;30.323511201872822;29.253144080288198;57.877939407651326;0.4492403446644656;1.016985997422756;3.453756316861062;2.4764807499345243;1.012233325850472;7.354237186082901;mleN;NhaC family malate/lactate antiporter;COG1757;Na+/H+ antiporter NhaC/MleN;NhaC;HELO_RS02940;C;mleN; NhaC family malate/lactate antiporter;;mleN;NhaC family malate/lactate antiporter;0.06699071241872412;-0.1615690837180228;-0.9606420979491466;-2.437485823429568;-2.5044765358482923
HELO_1558;33.61267956419315;34.702178401074754;226.18113873885662;68.77294161480995;113.33513369040416;236.58523242083592;1.7831462856942493;0.18973815500868738;14.053253088955953;2.3693049824463763;4.661408454145285;39.15732687654885;HELO_1558;TRAP transporter substrate-binding protein;COG4663;TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component;FcbT1;HELO_RS02945;Q;;mleN;;HELO_1558;TRAP transporter substrate-binding protein;-0.044711471250471924;-0.06460210243225895;-1.055176372380175;-2.7790726272071815;-2.7343611559567096
HELO_1558A;18.6846451260936;17.211904020403846;25.23850008736925;17.415024996902975;19.243388185062823;35.48639089122001;1.0166163878471284;2.2173447964371555;4.2884096217042265;5.7765962163546645;4.664984123031516;1.6804732523244255;HELO_1558A;TRAP transporter small transmembrane protein;COG4665;TRAP-type mannitol/chloroaromatic compound transport system, small permease component;FcbT2;HELO_RS02950;Q;;;;HELO_1558A;TRAP transporter small transmembrane protein;0.11218894262919221;-0.47567320026096027;-0.8499076739132967;-0.8902877476399613;-1.0024766902691535
HELO_1559;18.723499532519128;13.152871622478585;39.75639103273847;19.567233482034904;27.686006431517523;43.120922816888026;1.2986065080314533;1.0267611992147037;3.568658291295976;2.649405355090303;1.2004891502817372;4.310147723424026;HELO_1559;TRAP transporter large transmembrane protein;COG4664;TRAP-type mannitol/chloroaromatic compound transport system, large permease component;FcbT3;HELO_RS02955;Q;;;;HELO_1559;TRAP transporter large transmembrane protein;0.47882074514937667;-0.11443665921140589;-0.6211158311428076;-1.161547414897088;-1.6403681600464646
HELO_1560;215.98953569553223;75.29834352227249;677.6567767513142;610.7997692068647;588.3569868867157;618.6184067716786;16.801068873906964;3.8149613626041137;5.833811460279854;13.957437805673097;106.72212044394134;85.3150026737422;HELO_1560;alkaline phosphatase family protein;COG1785;Alkaline phosphatase;PhoA;HELO_RS02960;PR;;;3.1.3.1;HELO_1560;alkaline phosphatase family protein;1.5079018296508844;0.13130212929203644;-0.07223823044986766;-1.5137545318800933;-3.0216563615309777
HELO_1561;92.08093808646606;35.19308839566463;84.17390457872743;74.02122256421099;119.26248695529046;81.38994697889657;1.768167323050188;3.200156064188373;9.954250217510124;8.656577573615781;11.332181484598127;7.4449633325646785;HELO_1561;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS02965;K;;;;HELO_1561;GntR family transcription regulator;1.3627715308543067;0.04794317394088843;0.5456464788964563;0.17601743655265878;-1.186754094301648
HELO_1562;22.63222337491814;24.048598520512467;89.76606850007208;57.01087430730016;77.78390322123158;90.6833826317317;0.5344135149378231;0.6459347393096632;4.936787228339596;4.915963627534016;5.730408469171263;11.6706100518643;lhpC;1-pyrroline-4-hydroxy-2-carboxylate deaminase;COG0329;4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase;DapA;HELO_RS02970;ME;lhpC; 1-pyrroline-4-hydroxy-2-carboxylate deaminase;3.5.4.22;lhpC;1-pyrroline-4-hydroxy-2-carboxylate deaminase;-0.08397451846681392;-0.014507203961020565;-0.21875937817248747;-1.9559049050654362;-1.8719303865986223
HELO_1563;32.632739631774015;28.37819219787077;122.89569922387788;81.78800347767283;114.78110957800438;123.38184363181658;1.4089890288290612;1.9317272943816437;3.4768874503161133;3.2327508263337004;17.63784679533828;17.35694077011455;HELO_1563;2-ketoglutarate semialdehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS02975;I;;lhpC;1.2.1.26;HELO_1563;2-ketoglutarate semialdehyde dehydrogenase;0.19512068003117555;-0.005649798324625976;-0.10337601889159576;-1.8868376997875096;-2.081958379818685
HELO_1564;24.628789013637192;19.962998461013544;27.40256914756985;26.672733878535734;33.02655507416734;24.849351714239162;1.6872876239993475;0.1850560742906568;2.0800621647498763;0.8500309075280816;2.2215565851171513;2.5010192058681517;dmlA;D-malate dehydrogenase (decarboxylating);COG0473;Isocitrate/isopropylmalate dehydrogenase;LeuB;HELO_RS02980;CE;dmlA; D-malate dehydrogenase (decarboxylating);1.1.1.93,4.1.1.73,1.1.1.83;dmlA;D-malate dehydrogenase (decarboxylating);0.28992022263573247;0.1358933351716427;0.3965329978745675;-0.012362787663087182;-0.30228301029881965
HELO_1565;52.15938523380891;31.445963801331885;74.46921898085155;69.37023966184863;65.40444342563909;76.86411685043323;1.3659694618877851;0.5573954165256205;6.873670150149617;4.952304388404842;3.3142977511504266;3.268726856943655;HELO_1565;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02985;K;;dmlA;;HELO_1565;LysR family transcription regulator;0.7122853988962143;-0.04507028116343914;-0.22967884308394915;-0.550634204681022;-1.2629196035772363
HELO_1566;114.71015410300231;77.34164120525695;99.56170201925455;112.31644613077397;105.44045668846007;100.64973351543256;6.21195763539332;2.833533885877585;7.22948337748316;4.202087162565241;9.492973632921954;9.676292979187982;HELO_1566;probable glycosyltransferase%2C type 1;COG0438;Glycosyltransferase involved in cell wall bisynthesis;RfaB;HELO_RS02990;M;;;2.4.1.337;HELO_1566;probable glycosyltransferase%2C type 1;0.5626642159666737;-0.015525460153743786;0.06644017242252787;0.18690904016214382;-0.3757551758045299
HELO_1567;100.93242072611906;67.36469022467196;113.32695406867845;98.0300864380289;102.04617862793968;114.08927133958548;4.656238128330403;3.46163028514458;4.833386510556837;2.963384510777166;5.545729680240292;1.9045444212177278;HELO_1567;YdjX family protein;COG0398;Uncharacterized membrane protein YdjX, related to fungal oxalate transporter, TVP38/TMEM64 family;TVP38;HELO_RS02995;S;;;;HELO_1567;YdjX family protein;0.5762897065090726;-0.009587773420371093;-0.15946234636320256;-0.17514036172525493;-0.7514300682343276
HELO_1568;4.584089058777416;14.708990054294013;10.830866546835132;7.274873566504469;12.145762750712374;12.374378830884467;0.559362776279448;0.4375141063174668;0.9388239109668117;0.8567187362704279;1.2817287020187398;0.8248280997241318;HELO_1568;ABC-type transport system periplasmic substrate-binding protein;COG2113;ABC-type proline/glycine betaine transport system, periplasmic component;ProX;HELO_RS03000;E;;;;HELO_1568;ABC-type transport system periplasmic substrate-binding protein;-1.4921965754894742;-0.17691614038215775;-0.024874034286645585;-1.2600780316136708;0.23211854387580333
HELO_1569;2.7757365223647814;6.808561661736436;5.93221351137862;5.214748288962954;6.404841925097505;5.982966211992643;0.43921602110244423;0.9126037821929123;0.4790156121009075;0.32241036012415086;0.20779396953199666;0.47866443421862276;HELO_1569;gamma-butyrobetaine dioxygenase;COG2175;Taurine dioxygenase, alpha-ketoglutarate-dependent;TauD;HELO_RS03005;Q;;;1.14.11.1;HELO_1569;gamma-butyrobetaine dioxygenase;-1.0482987338134542;-0.0105239020442367;0.08462894583485792;-0.8870818976912636;0.16121683612219062
HELO_1570;42.72472432173438;25.84670745890121;60.25306899411343;59.55452683734063;58.291607607506414;59.54077592061109;2.119719210910952;2.467741836352482;8.708530651650259;2.733337318633868;3.8694111026830984;2.162101218212438;HELO_1570;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS03010;K;;;;HELO_1570;LysR family transcription regulator;0.7037041245179196;0.01687496444085923;-0.03007925169951342;-0.46945787739376765;-1.1731620019116873
HELO_1571;98.0864127590035;48.5018744936672;280.8902927824076;489.6801537785711;1040.6305110995156;376.6288970075166;2.3458490531990637;3.617015564288319;48.4736419550289;53.38351868979033;271.23929863364884;108.53676421901565;HELO_1571;DUF411 domain protein;COG3019;Uncharacterized metal-binding protein, DUF411 family;;HELO_RS03020;S;;;;HELO_1571;DUF411 domain protein;1.0012040842343657;-0.42183536927927534;1.4638025408986497;-1.9302100208870705;-2.931414105121436
HELO_1572;3.8641171343920564;2.5831530558647215;5.111208204822984;6.793568717111431;10.348042832131473;6.664131997639228;0.40140655216142807;0.20474850816968512;0.3132888431749327;1.2819968295690103;2.103400474943525;0.947408604559329;HELO_1572;probable glycosyltransferase%2C type 9;COG0859;ADP-heptose:LPS heptosyltransferase;RfaF;HELO_RS03025;M;;;;HELO_1572;probable glycosyltransferase%2C type 9;0.44094830102969573;-0.3266647749751521;0.5662491874371187;-0.6559444372936785;-1.0968927383233742
HELO_1573;8.2165616348843;3.6730923341931874;5.2116879320063445;7.470864564809204;6.803272490822779;5.334993567138166;0.4415534966033749;0.2475112284463931;0.39067358369160843;0.33598901724492064;0.3777068887004792;0.3297781499170343;HELO_1573;EptA family protein;COG2194;Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily;OpgE;HELO_RS03030;M;;;2.7.8.43;HELO_1573;EptA family protein;0.9798510905396647;-0.028357802162788825;0.30073612550990214;0.5408854794074611;-0.43896561113220356
HELO_1574;8.265783275837057;2.6609857049099412;3.2267600831463876;5.268659360549865;3.8479847263290416;3.6582550753547225;1.57779429470495;0.10675819572386659;0.3717572521466452;0.7576997752516169;0.7800639985669366;1.129954083723243;HELO_1574;uncharacterized protein;;;;;;;;;HELO_1574;uncharacterized protein;1.3396807981725942;-0.14023741508957155;0.0575955131985757;0.9921232981388584;-0.34755750003373587
HELO_1575;154.02164997880536;44.157290780510266;55.24215511467051;66.07405617408511;47.28801692348346;48.30708171016956;4.056066157551226;1.7185989805161692;6.583655260393185;2.2695821759923502;3.838283638408939;2.006910606276295;HELO_1575;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS03040;KT;;;;HELO_1575;response regulator/HTH domain transcription regulator;1.7794388740697036;0.18985700937957262;-0.030129651392881485;1.6526029400468323;-0.1268359340228713
HELO_1576;87.76160885102405;18.42120264563428;27.3516467070522;29.661164784313286;26.96525391480806;24.87288186831456;1.1757213960355013;1.1469175202708646;0.5599650463830128;1.1614689041765156;0.9295187662930396;3.4371745501313407;HELO_1576;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS03045;T;;;2.7.13.3;HELO_1576;sensor histidine kinase;2.1923032758841456;0.13199177300956233;0.11219467102517555;1.7784950588527577;-0.4138082170313879
HELO_1577;86.57020130516038;62.33846394635075;59.19875405671757;64.64392511628242;60.29570109860101;57.96385549680449;6.349981424215944;4.678709396949137;3.4320282632747077;3.2973924606893927;2.213770591806456;8.745150452059141;HELO_1577;MtfA family protein;COG3228;Mlc titration factor MtfA, regulates ptsG expression;MtfA;HELO_RS03050;T;;;;HELO_1577;MtfA family protein;0.4673581477611659;0.029902765919935348;0.055955034072987964;0.570609166329394;0.10325101856822805
HELO_1578;98.49786053677691;65.48651647410905;126.50783958807186;133.2816320983063;139.20207477567862;127.11681590007258;3.9467218635672605;3.03955480730384;11.913886781454618;6.387772283559938;12.786817136278518;9.959235339485971;HELO_1578;GNAT family acetyltransferase / carbon-nitrogen hydrolase domain protein;COG0388;Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate;Nit2;HELO_RS03055;C;;;;HELO_1578;GNAT family acetyltransferase / carbon-nitrogen hydrolase domain protein;0.5816037138740588;-0.006873896930943424;0.13004785095254867;-0.36472243882748856;-0.9463261527015474
HELO_1579;57.742795040948145;35.01858006674451;59.28051833007502;47.05094334161066;45.20992317758539;55.980988315098195;5.0520969978897785;1.7870293016428471;3.7116865922072937;2.3105307505955586;3.0551771001419357;2.7100945784718933;HELO_1579;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS03060;GER;;;;HELO_1579;DMT superfamily transport protein;0.7056706040799243;0.08121117728052596;-0.30227795383888445;0.04393126725484553;-0.6617393368250788
HELO_1580;13.017269523170805;3.6195839390596785;18.339925656656018;20.389976478969984;19.153114237750998;21.706848820958893;0.15769879929483618;0.22024454393739473;1.282017500939759;1.8837469276311902;0.2859493329589867;1.2207555173626075;betG;BCC family transport protein BetG (substrate glycine-betaine);COG1292;Choline-glycine betaine transporter;BetT;HELO_RS03065;M;betG; BCC family transport protein BetG (substrate glycine-betaine);;betG;BCC family transport protein BetG (substrate glycine-betaine);1.6013705218393142;-0.23154525858250974;-0.17212471363929183;-0.6959221589334872;-2.2972926807728014
HELO_1581;3.0979427313084984;3.1530699813833576;3.709281379525882;3.2506273767508382;2.85443150348634;3.930772045238634;0.6391170870312344;0.1279963230997443;0.9901507996924942;0.19660654973925107;0.2335865700324052;0.16779938174908732;betC;choline-sulfatase;COG3119;Arylsulfatase A or related enzyme, AlkP superfamily;AslA;HELO_RS03070;P;betC; choline-sulfatase;3.1.6.6;betC;choline-sulfatase;-0.01927835927996613;-0.06630663084608379;-0.35529546673683576;-0.2669137342290604;-0.24763537494909427
HELO_1582;19.480199701908557;15.496963491780669;39.24805226585875;29.76666369981602;35.17636270093929;38.87747162062998;0.5274540021394593;0.717373039855957;5.4263804541485126;0.5368160480295772;5.6322398793434445;1.2347408176337267;HELO_1582;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS03075;K;;betC;;HELO_1582;LysR family transcription regulator;0.3120292833755487;0.013345027783836727;-0.14052657882328656;-0.9613441573385222;-1.2733734407140709
HELO_1583;99.85838689966609;89.25806145070516;169.06054929631503;154.0224916657854;283.0215280410086;167.2721844507936;6.186575801291359;2.5406757900648147;21.526655938691082;13.71416931186195;18.285829684608004;13.136172398067421;HELO_1583;zinc finger domain protein;COG1734;RNA polymerase-binding transcription factor DksA;DksA;HELO_RS03080;K;;;;HELO_1583;zinc finger domain protein;0.1602033585334528;0.01525178539272165;0.7552035686028233;-0.73846566100024;-0.8986690195336928
HELO_1584;33.25411780068109;51.51883683125275;82.67732239460798;69.93145137977625;214.80734191401288;80.56603004960208;0.7589214182408889;2.802600446900692;8.317922523946951;15.489489734809721;17.884806349271773;9.207549619024109;glcG;HbpS family protein GlcG;COG3193;Formaldehyde-binding sensor protein EfgA, GlcG/HbpS family;EfgA;HELO_RS03085;T;glcG; HbpS family protein GlcG;;glcG;HbpS family protein GlcG;-0.6165575346456187;0.03686825177524966;1.403703606529258;-1.2516910058591524;-0.6351334712135337
HELO_1585;18.18166745900351;26.09334054699157;23.326663061941478;25.88239071180107;49.76354100928463;24.780619997255897;1.8413009886366403;1.937448944839361;1.9755333247613658;0.5702984914516702;1.7502322542643112;2.5057293552708946;glcF;glycolate oxidase subunit GlcF;COG0247;Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF;GlpC;HELO_RS03090;C;glcF; glycolate oxidase subunit GlcF;;glcF;glycolate oxidase subunit GlcF;-0.49821014647405093;-0.08374852301818247;0.9775057483976353;-0.4265588204053934;0.07165132606865754
HELO_1586;27.697483486734424;28.80368554257981;23.926633074031983;27.677593803573785;56.94831643835946;26.647484519896363;2.5677731736536407;1.9147080017837086;1.3891518383819157;2.4029259994833603;0.9812468529921807;3.1360538247556966;glcE;glycolate oxidase subunit GlcE;COG0277;FAD/FMN-containing lactate dehydrogenase/glycolate oxidase;GlcD;HELO_RS03095;C;glcE; glycolate oxidase subunit GlcE;;glcE;glycolate oxidase subunit GlcE;-0.05456651533509316;-0.14946019798045462;1.0676185232965727;0.05377600677029726;0.10834252210539042
HELO_1587;47.63085813570172;44.91075135334538;46.95977197588337;57.998756604346966;96.03836033363505;48.251961200912376;1.1056050407747409;2.0534330288453533;5.51117896673468;4.207952638439377;4.887145561956122;3.7924311777315607;glcD;glycolate oxidase subunit GlcD;COG0277;FAD/FMN-containing lactate dehydrogenase/glycolate oxidase;GlcD;HELO_RS03100;C;glcD; glycolate oxidase subunit GlcD;1.1.3.15;glcD;glycolate oxidase subunit GlcD;0.08304000676792533;-0.038356373978996494;0.9783739998371379;-0.01830912400573048;-0.10134913077365582
HELO_1588;258.1776456885512;169.18763719146185;432.82230712156087;336.45325812726236;518.727029303966;450.32390841820046;4.088241333780682;10.616527758298682;14.835375396031797;5.590832132852642;11.302717767268835;23.971712851211706;HELO_1588;glutathione S-transferase domain protein (homolog to beta-etherase);COG0625;Glutathione S-transferase;GstA;HELO_RS03105;O;;glcD;;HELO_1588;glutathione S-transferase domain protein (homolog to beta-etherase);0.6068150495548084;-0.05705896763031326;0.20359088495484556;-0.8002219160474038;-1.4070369656022121
HELO_1589;27.549354884780303;16.617254116233724;21.252545970793644;29.316093242609437;28.03642284105021;19.71391544827646;2.0868148628268957;1.2116910116076975;1.0620157574603304;5.665812334554495;4.140549803574434;1.19578203499685;HELO_1589;phosphoribosyltransferase domain protein;COG1926;Predicted phosphoribosyltransferase;;HELO_RS03110;R;;;;HELO_1589;phosphoribosyltransferase domain protein;0.6964690675744674;0.10337012316372274;0.4872634458342695;0.4628578613176577;-0.23361120625680964
HELO_1590;24.24903637486901;20.776868085563162;35.08512819976616;26.480523392744928;33.57789891091352;33.2880831108688;0.2245263065250526;1.8032648912300164;5.341757091241449;5.415948344257691;2.08833174569942;1.8748509775037352;HELO_1590;2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase;COG3195;2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) decarboxylase (uric acid degradation);PucL;HELO_RS03115;F;;;;HELO_1590;2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase;0.213431845833286;0.07369712816146912;0.012142955741431649;-0.44147892337221606;-0.6549107692055021
HELO_1591;16.50493040513577;27.40783516558577;30.67153314854895;19.145730250126125;30.22522041298016;27.977625285347642;1.7538578911981124;2.149779019973006;4.579366604619886;2.150539458735039;0.5451690156063608;5.173611835561109;HELO_1591;5-hydroxyisourate hydrolase;COG2351;5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family;HiuH;HELO_RS03120;F;;;3.5.2.17;HELO_1591;5-hydroxyisourate hydrolase;-0.6985275683489958;0.12824733575090086;0.10777238461613425;-0.7271780449541012;-0.028650476605105446
HELO_1592;32.251133407049764;43.459082518704555;40.723847976758215;29.550149989060973;43.91510111479329;47.2980302037945;1.6203220455031073;1.9734597251581785;3.238066818224825;1.245931717010617;1.3937151445696245;0.8862489422128171;HELO_1592;DUF989 domain protein;COG3748;Uncharacterized membrane protein;;HELO_RS03125;S;;;;HELO_1592;DUF989 domain protein;-0.4190746589071983;-0.21109213474079436;-0.10476376937968812;-0.53856083356529;-0.11948617465809175
HELO_1593;200.5983454178798;106.26372504034565;171.64058129891274;166.04139323107958;174.32742007524374;185.3081304968783;6.6816225212948295;4.1464310931440815;19.3108949873568;6.188984394700247;5.363197038461174;5.151590474920645;HELO_1593;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS03130;K;;;;HELO_1593;GntR family transcription regulator;0.9103215371614315;-0.10991900729087689;-0.08763899302087896;0.1137931632837672;-0.7965283738776643
HELO_1594;8.377455596980079;3.8754989770116612;10.343920313598202;10.099690908728652;8.48192668814827;11.10771418609779;0.12476223431424453;0.5231338034540759;1.3602725466319374;0.3042527044238225;0.9954968541612494;1.0975403110051254;HELO_1594;NCS1 family transport protein;COG1953;Cytosine/uracil/thiamine/allantoin permease;FUI1;HELO_RS03135;FH;;;;HELO_1594;NCS1 family transport protein;0.9436466493365652;-0.09400722113317395;-0.35267438084807345;-0.3686580927796417;-1.3123047421162068
HELO_1595;6.537712935790331;2.9928031639802875;11.100901837766948;10.042732070831862;7.893156031416083;11.31951231659424;0.5396030175378959;0.15467093113692693;0.4151413904607502;0.4801742222754296;0.4566606254112464;2.067434628392427;HELO_1595;NCS1 family transport protein;COG1953;Cytosine/uracil/thiamine/allantoin permease;FUI1;HELO_RS03140;FH;;;;HELO_1595;NCS1 family transport protein;0.9167249006687901;-0.025830575756239593;-0.4701777430349532;-0.708746388308104;-1.625471288976894
HELO_1596;16.034836510828168;3.4026699403145426;7.890852636835178;10.621276925762654;7.524937259008804;8.756715603269852;0.9805355976567706;0.22162254127114211;0.9628003798609085;0.46881781910664116;1.4870200823345874;1.6711404346855114;HELO_1596;allantoin racemase;COG4126;Asp/Glu/hydantoin racemase;Dcg1;HELO_RS03145;E;;;5.1.99.3;HELO_1596;allantoin racemase;1.9520375040883833;-0.13407379522953367;-0.19470635966215344;0.804020620315093;-1.1480168837732903
HELO_1597;30.98193392789779;28.215638747501956;55.72343835045165;62.09363216400629;50.308538214473394;51.82091668750445;1.1533698074492533;0.7363441547636506;4.499864917268151;7.161097615957286;4.968715033981075;5.792812045042914;puuE;allantoinase;COG0726;Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family;CDA1;HELO_RS03150;MG;puuE; allantoinase;3.5.2.5;puuE;allantoinase;0.13051634877352214;0.10283564653251975;-0.041910415577123494;-0.7238521588231182;-0.8543685075966403
HELO_1598;23.09788631725105;12.111511939563504;47.92047136272186;32.15175033505394;143.4024986828879;56.140360304004815;1.4255304506820516;1.3541800407831495;4.661380812060756;2.393608096920695;4.857814690303715;10.640141127344444;HELO_1598;YcgA family transport protein;COG1288;Predicted membrane transporter YfcC, affects glyoxylate shunt;YfcC;HELO_RS03155;R;;puuE;;HELO_1598;YcgA family transport protein;0.8780725518590611;-0.22407182864320063;1.3375136677899828;-1.2456035235528091;-2.12367607541187
HELO_1599;88.6007098553877;23.468458572442714;72.85708193714727;66.66451499542522;107.96599114062252;70.3889449493886;3.9753875796540425;3.0455190434138775;0.819341149969469;5.309007473254028;5.121052010003164;8.397625063622172;allA;ureidoglycolate lyase;COG3194;Ureidoglycolate hydrolase (allantoin degradation);AllA;HELO_RS03160;F;allA; ureidoglycolate lyase;4.3.2.3;allA;ureidoglycolate lyase;1.8725869424555466;0.04903558270795649;0.6101053467499105;0.32780948130381393;-1.5447774611517326
HELO_1600;209.95226859459578;63.91244500974498;109.50875776531484;115.97103054811116;186.19645595947154;115.16470433543527;10.068869899198312;3.3585238805172057;10.55658724426869;8.681917268590675;10.093940791934749;7.242024657973007;allE;allantoicase / (S)-ureidoglycine aminohydrolase;COG3257;Ureidoglycine aminohydrolase;AllE;HELO_RS03165;F;allE; allantoicase / (S)-ureidoglycine aminohydrolase;3.5.3.26;allE;allantoicase / (S)-ureidoglycine aminohydrolase;1.7003495992239204;-0.07201107758909586;0.6883813371735767;0.8607448178613222;-0.8396047813625982
HELO_1601;5.580352458861637;4.971003235068678;5.9693969835303236;5.706888470675268;50.549933366000374;5.823177776549592;0.3885060729920883;0.36612476874881306;0.048548900858890125;0.555148885228591;2.9140218988949336;0.5332695492362716;gcl;glyoxylate carboligase;COG3960;Glyoxylate carboligase;Gcl;HELO_RS03170;Q;gcl; glyoxylate carboligase;4.1.1.47;gcl;glyoxylate carboligase;0.14019150974429095;0.03059002857740989;2.91745485171585;-0.052278945817497924;-0.19247045556178888
HELO_1602;16.971037508917817;20.456449269069324;20.923612879840565;25.425922571799788;105.03318248460685;21.024716636121198;1.4056508081993728;1.1893478021051667;1.7514312103354224;1.1586212074261084;8.674455231423602;2.4113441080769746;hyi;hydroxypyruvate isomerase;COG3622;Hydroxypyruvate/dehydroerythronate isomerase, Hyi/OtnI family;Hyi;HELO_RS03175;G;hyi; hydroxypyruvate isomerase;5.3.1.22;hyi;hydroxypyruvate isomerase;-0.25573764943485955;-0.006637892576430993;2.267320455634633;-0.293449756629804;-0.037712107194944444
HELO_1603;36.70931964440293;41.29552257363674;51.508610689813345;48.798431578587305;197.71678512704966;48.48391787412248;1.5452671551592247;3.3226426496238566;2.2370159104499137;0.5841117017032911;10.177201387024619;7.071251167611945;glxR1;2-hydroxy-3-oxopropionate reductase;COG2084;3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase;MmsB;HELO_RS03180;I;glxR1; 2-hydroxy-3-oxopropionate reductase;1.1.1.60;glxR1;2-hydroxy-3-oxopropionate reductase;-0.16558382551380113;0.08559429454238998;2.0056821038119557;-0.39203860832129855;-0.22645478280749742
HELO_1604;26.197343473327532;15.003544676069504;37.20620134694465;35.822712130617695;65.82826880657879;35.82860414932366;1.0243964467355124;1.2502220256232208;2.7218120270488955;2.2963630703001563;2.2785810829498963;2.9859313299509704;gckA;glycerate 2-kinase;COG2379;Glycerate-2-kinase;GckA;HELO_RS03185;G;gckA; glycerate 2-kinase;2.7.1.165;gckA;glycerate 2-kinase;0.7650742541069429;0.052980106508004;0.859631783195308;-0.4373609765750812;-1.202435230682024
HELO_1606;196.65556106704796;125.43733566351807;225.6117021600143;189.8626885843787;227.29674228535944;217.56437570272524;11.714997491164185;6.839505355553412;26.40465480469496;13.535939710421662;12.673923574042043;11.3062765219942;HELO_1606;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS03195;K;;pykA2;;HELO_1606;GntR family transcription regulator;0.6445660065097307;0.05216409134484845;0.0628520008815876;-0.1450697259177094;-0.7896357324274401
HELO_1607;4.280480908726914;6.564972040923806;12.614872945372085;13.977455569403965;16.410359547347067;13.837582370437536;0.38850135928990953;0.6602266691603943;1.8824222571436084;2.061687831244399;0.5906666179158824;1.8042779420365351;azoR2;FMN-dependent NADH-azoreductase;COG1182;FMN-dependent NADH-azoreductase;AzoR;HELO_RS03200;C;azoR2; FMN-dependent NADH-azoreductase;1.7.1.17;azoR2;FMN-dependent NADH-azoreductase;-0.5186654244602096;-0.12407251982467393;0.2306899579181878;-1.4905148078662815;-0.971849383406072
HELO_1608;33.227862418565074;19.949583420781327;25.17373958139343;24.920544903579728;24.997377814289823;27.206317069383676;0.6172482039057191;0.1709593170290009;1.2740709575472005;0.29139351709207817;2.1945597370349588;1.146314974013672;HELO_1608;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS03205;K;;azoR2;;HELO_1608;LysR family transcription regulator;0.7082496402454828;-0.1078982392759853;-0.11765218853737114;0.2791528927853735;-0.4290967474601093
HELO_1609;168.588049178073;64.31891216640055;154.89776112909286;162.49420894149483;189.1163995583357;169.55796401920983;10.284115183994546;4.6692889364584005;9.449797816593128;5.658192145241688;12.635268616336242;9.372649887393576;HELO_1609;DUF192 family protein;COG1430;Uncharacterized conserved membrane protein, UPF0127 family;;HELO_RS03210;S;;;;HELO_1609;DUF192 family protein;1.3764618378766578;-0.12966191217822587;0.15662086351681914;-0.00822761443380493;-1.3846894523104627
HELO_1610;22.98916553006728;7.137618413351286;21.051604487532284;26.617521899900584;19.037737007468746;24.62718429342726;1.6725532693529768;1.2859140062150236;1.4958981845065806;1.8664138453058414;1.4584348692269216;1.863984298122757;pgpA2;phosphatidylglycerophosphatase PgpA;COG1267;Phosphatidylglycerophosphatase A;PgpA;HELO_RS03215;I;pgpA2; phosphatidylglycerophosphatase PgpA;3.1.3.27;pgpA2;phosphatidylglycerophosphatase PgpA;1.5597044372403839;-0.2167913448100336;-0.3549553909818348;-0.09529200179219277;-1.6549964390325766
HELO_1611;6.660144141304053;3.1814274143742054;4.961406285187917;4.950067048845974;5.694495700924295;4.229195910106891;0.4222499273008985;0.2819167133833112;0.5573295390041108;0.07369001071669064;0.6516161492384374;0.07329757226860396;HELO_1611;ChrA family transport protein;COG2059;Chromate transport protein ChrA;ChrA;HELO_RS03220;P;;pgpA2;;HELO_1611;ChrA family transport protein;0.8733760203039145;0.1890635787480912;0.35638625954733927;0.5507824183752286;-0.3225936019286859
HELO_1612;12.638592312187546;21.769122061168417;28.770080527479546;28.403942523984117;34.546752318794375;31.393788938247013;0.6619141435613843;0.17193220837352013;2.337827484182792;1.4691977836400336;2.0697008787283218;2.226474995714954;HELO_1612;HAD superfamily hydrolase;COG2503;Predicted secreted acid phosphatase;;HELO_RS03225;R;;;;HELO_1612;HAD superfamily hydrolase;-0.739383918327142;-0.12185409872830011;0.13400053320293992;-1.2480224764316667;-0.5086385581045247
HELO_1613;82.30779896480654;38.64275062100119;64.88422787538111;67.57632970932542;69.68785164763982;66.38181187223255;1.1000181822311457;2.874655422195972;1.7797396379639787;3.0180658702216596;5.7464157791175206;6.866278661545453;HELO_1613;homolog to potassium channel protein;;;;;;;;;HELO_1613;homolog to potassium channel protein;1.0713944939201179;-0.03242608489679544;0.06910307350739942;0.3060923391089938;-0.7653021548111241
HELO_1614;124.71557908132735;58.6418191321994;132.84642793708886;119.3067985721239;137.57078794624022;137.5685532031455;8.168591579070434;2.2743745598676064;11.856428387446737;6.236345111016733;15.020538615367641;11.96666329904991;ygiF;inorganic triphosphatase;COG3025;Inorganic triphosphatase YgiF, contains CYTH and CHAD domains;PPPi;HELO_RS03235;P;ygiF; inorganic triphosphatase;3.6.1.25;ygiF;inorganic triphosphatase;1.0757672772987767;-0.05002125171691496;2.326665544494233e-05;-0.1404364446189641;-1.2162037219177408
HELO_1615;325.70959212754974;229.13698124990546;219.49037558377316;200.42037755519652;238.64817038448223;231.20689481245793;11.241329433219258;18.270379300201835;5.49934026192658;4.0658052731383005;26.852966073462493;7.539266201675109;HELO_1615;UPF0111 family protein;COG1392;Phosphate transport regulator YkaA, distantly related to PhoU, UPF0111/DUF47 family;YkaA;HELO_RS03240;P;;ygiF;;HELO_1615;UPF0111 family protein;0.5055159804005589;-0.07469512667486278;0.045507115494496375;0.4925980025130752;-0.012917977887483723
HELO_1616;289.47156482503834;166.39339738589726;172.16082585219638;142.55918254516357;192.30749901431932;182.1414082882991;2.577653252577928;2.652896818975693;13.39773642769762;15.959927670272627;12.44787027567931;10.23707982740253;HELO_1616;PHO4 family transport protein (probable substrate phosphate);COG0306;Phosphate/sulfate permease;PitA;HELO_RS03245;P;;;;HELO_1616;PHO4 family transport protein (probable substrate phosphate);0.7951543168000983;-0.08084543519718412;0.07793958388506894;0.6654389190966299;-0.1297153977034684
HELO_1617;133.25510520443234;77.53909088449701;117.79273440959264;118.53640647132774;106.95460577838575;100.60761579676942;9.418639085870367;1.859466916385544;12.954538283714628;12.646471703548276;10.619117277248112;3.4258159338646545;argA;N-acetylglutamate synthase;COG1246;N-acetylglutamate synthase or related acetyltransferase, GNAT family;ArgA;HELO_RS03250;E;argA; N-acetylglutamate synthase;2.3.1.1;argA;N-acetylglutamate synthase;0.773494145838578;0.22543806035381753;0.08741625535551467;0.40196840888778684;-0.37152573695079116
HELO_1618;102.84437911365472;29.16987186413769;63.31895665819866;72.97856388883206;54.962790883551385;55.91471227459275;0.8757062180212116;1.0377714153320998;1.4254489969075768;3.0410364917686317;1.4533675039386185;5.285278413934117;glrK;sensor kinase protein GlrK;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS03255;T;glrK; sensor kinase protein GlrK;2.7.13.3;glrK;sensor kinase protein GlrK;1.7832426538561768;0.17644237132826301;-0.024333720891042354;0.8675495901330921;-0.9156930637230847
HELO_1619;194.200840515981;44.14291665004467;94.23310853355851;111.06918380005219;82.84667291358959;99.18170285344797;6.979170971030653;3.02929020516813;5.617481005900386;10.65988948962403;1.2861641152530596;10.969122573340659;HELO_1619;uncharacterized protein;;;;;;;;;HELO_1619;uncharacterized protein;2.1123877269197164;-0.07308390929629827;-0.25679359631006715;0.96234022567862;-1.1500475012410964
HELO_1620;162.5389372793966;46.59235408373838;127.13611363960909;146.59205386729724;129.8329905702727;128.4416331056469;7.326554436264571;1.805761900193249;5.704933061500758;7.813929120198487;7.641962199468662;5.149521085616955;glrR;response regulator/sigma-54-interact/HTH domain transcription regulator GlrR;COG2204;DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains;AtoC;HELO_RS03265;T;glrR; response regulator/sigma-54-interact/HTH domain transcription regulator GlrR;;glrR;response regulator/sigma-54-interact/HTH domain transcription regulator GlrR;1.7808324483737792;-0.014624575389086125;0.015424658824482407;0.33733245565945147;-1.4434999927143277
HELO_1621;74.74512781917628;76.97616279475993;110.28471901088335;119.963300295073;104.0786051945551;105.37434885080461;4.758217304174595;4.788824805764469;12.733212806776715;2.717127862083668;12.575192567886937;9.948646239453138;xseA;exodeoxyribonuclease 7 large subunit;COG1570;Exonuclease VII, large subunit;XseA;HELO_RS03270;L;xseA; exodeoxyribonuclease 7 large subunit;3.1.11.6;xseA;exodeoxyribonuclease 7 large subunit;-0.04188006890810403;0.06510520277408016;-0.017681345283952155;-0.48992530307463245;-0.4480452341665284
HELO_1622;3.340915215563031;1.463145224967139;1.330940319575424;2.3524250856821936;3.10048931360746;1.771887720892389;0.47329112828223174;0.3784784036142756;0.7287766176874529;1.0955568896023644;0.3466026433241723;0.25311202376357117;HELO_1622;AbrB family protein;COG3180;Uncharacterized membrane protein AbrB, regulator of aidB expression;AbrB;HELO_RS03280;R;;;;HELO_1622;AbrB family protein;0.8174975544885776;-0.24995675354355051;0.5649272572622692;0.6471304245965728;-0.17036712989200486
HELO_1623;4.148613542768046;2.24504765658658;4.0155039522630736;5.246594918738675;7.241494080327107;4.038032430658331;0.19051274574355362;0.19342868745899588;0.22153556916029446;0.9239457126093935;0.9047324231746231;0.2803677106203796;HELO_1623;TTT family transporter large transmembrane protein;COG3333;TctA family transporter;;HELO_RS03285;R;;;;HELO_1623;TTT family transporter large transmembrane protein;0.6659443191473253;-0.006465740456566671;0.7100454948063128;0.03132357589360524;-0.6346207432537201
HELO_1624;1.5343825153954909;0.9802967402995497;0.9171403564539059;1.706712473385671;3.275172206626595;1.0259814630976418;0.5655542232003585;0.43906858921697534;0.1329529908046978;1.1038653433745196;1.1536575069070656;0.547156630477741;HELO_1624;TTT family transporter small transmembrane protein;;;;;;;;;HELO_1624;TTT family transporter small transmembrane protein;0.3559176583344472;-0.07966501159001027;1.0773615597035722;0.32301331333914396;-0.03290434499530326
HELO_1625;1.8483931530026165;1.3152055338139765;5.3892461467390484;10.545051503624004;23.22276550701812;5.751737248924951;0.23405739014093108;0.34003825800553183;0.7730062130721611;0.29522660890422486;2.534567165311944;0.14937151828938944;HELO_1625;TTT family transporter substrate-binding protein;COG3181;Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC;TctC;HELO_RS03295;C;;;;HELO_1625;TTT family transporter substrate-binding protein;0.29900801450083936;-0.07961304035487737;1.8430329203339642;-1.2451104712942789;-1.5441184857951182
HELO_1626;137.40367476667274;75.52942724430848;168.08920058494093;180.45054476112395;154.92340363589707;172.7467913302951;11.844166800628738;5.022490768250828;7.182177117887165;6.2278077216520265;11.872396314447471;2.4483704361341663;HELO_1626;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS03300;KT;;;;HELO_1626;response regulator/HTH domain transcription regulator;0.8547957410841756;-0.0392018146829729;-0.1561488466111216;-0.32810408651377276;-1.1828998275979483
HELO_1627;83.05291420476532;48.342228398973845;63.198821320109545;76.98236834669748;61.4492869402664;66.07555815267548;2.3509907816135454;3.7678837547403536;4.352283975189294;3.468021933483065;1.978653120893331;2.7553156106157988;HELO_1627;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS03305;T;;;2.7.13.3;HELO_1627;sensor histidine kinase;0.7684749678579319;-0.06324034462083894;-0.10310205564881425;0.32551068554848595;-0.44296428230944596
HELO_1628;28.454217204379095;13.621661343305666;12.289759842788248;14.763612833449743;13.375469883005854;13.434947533514256;0.8649260008111359;0.4883883396586528;2.069962208758349;0.5796630712894316;0.5661779511231995;0.5878022292351353;HELO_1628;ABC-type transport system periplasmic substrate-binding protein;COG1840;ABC-type Fe3+ transport system, periplasmic component;AfuA;HELO_RS03310;P;;;;HELO_1628;ABC-type transport system periplasmic substrate-binding protein;1.0103669688617116;-0.11925082971271372;-0.005956750441709957;1.0289083476085796;0.01854137874686801
HELO_1629;537.7096429638591;370.7408069689437;506.67481868323966;495.9737501150915;470.67133060919286;483.8661797764492;21.454521160109223;2.38559386615859;15.58032278341089;15.875027911103059;25.68152685123111;14.9829907822009;guaB;inosine-5'-monophosphate dehydrogenase;COG0517;CBS domain;CBS;HELO_RS03315;T;guaB; inosine-5'-monophosphate dehydrogenase;1.1.1.205;guaB;inosine-5'-monophosphate dehydrogenase;0.5352108244807177;0.06631807547124957;-0.03980471402684138;0.15192126295156783;-0.38328956152914984
HELO_1630;185.37735013474435;142.91510150738236;245.92165135900817;198.30783826550623;262.3783414714308;253.78094363635554;4.983368155220625;5.19564832250715;14.312835823983214;9.614659889476322;7.38733500204385;4.987177849656523;guaA;GMP synthase (glutamine-hydrolyzing);COG0519;GMP synthase, PP-ATPase domain/subunit;GuaA2;HELO_RS03320;F;guaA; GMP synthase (glutamine-hydrolyzing);6.3.5.2;guaA;GMP synthase (glutamine-hydrolyzing);0.3730085573782329;-0.045204030183231936;0.047879337454329374;-0.451030830763389;-0.8240393881416219
HELO_1631;4.877140723030387;3.636819525442412;5.275361871558875;9.758640890402182;8.610349694395715;6.575343613573275;1.7765799507275273;0.6539397214509987;1.5669130747246753;1.4150831872142915;2.1025758773315015;1.6650237840012792;HELO_1631;isochorismatase family hydrolase;COG1335;Nicotinamidase-related amidase;PncA;HELO_RS03330;HR;;;;HELO_1631;isochorismatase family hydrolase;0.3419788676745914;-0.2716126748333254;0.343277597736527;-0.3661968871325625;-0.7081757548071539
HELO_1632;123.60701543799247;26.921283539336628;99.70153560684729;113.27582863393341;97.37576789781868;95.53652703228424;3.921737252178265;0.19610060559359935;10.100581197216915;1.7354772443288957;16.683645144790496;14.63493470560897;rlmA;23S rRNA (guanine(745)-N(1))-methyltransferase RlmA;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS03345;H;rlmA; 23S rRNA (guanine(745)-N(1))-methyltransferase RlmA;2.1.1.187;rlmA;23S rRNA (guanine(745)-N(1))-methyltransferase RlmA;2.1579481263401545;0.060938852413958244;0.027228066224693315;0.368238464223003;-1.7897096621171515
HELO_1633;24.71047891418844;15.34458691564342;11.361531882663654;11.949007462514048;7.688956228707775;12.663231276780992;4.01997978522889;3.7932314989684213;0.5207658763368925;0.43142039090674017;1.710038532729408;1.7302192776201102;HELO_1633;TerC family protein;COG0861;Tellurite resistance membrane protein TerC;TerC;HELO_RS03350;P;;rlmA;;HELO_1633;TerC family protein;0.6535435681261168;-0.14444117523257383;-0.6530439260939009;0.9120577706065629;0.2585142024804461
HELO_1634;22.972099642004903;4.219063323137729;15.278393375728884;21.324393936957918;19.82633057478591;15.381572354355844;1.5422916549636432;0.1204144674057479;3.8788402887439757;1.1591589936350388;3.3668687847097893;2.0867949572007474;anr;Crp family transcription regulator Anr;COG0664;cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases;Crp;HELO_RS03355;T;anr; Crp family transcription regulator Anr;;anr;Crp family transcription regulator Anr;2.1994934642508994;-0.00911552064930099;0.3463348329823823;0.5492824377240222;-1.6502110265268772
HELO_1635;2.534524652019162;2.528566855196094;3.587041228103058;3.343735732281031;4.795720579178412;3.8028474884665022;0.5709156159246593;0.23374584136411264;0.4965770470267956;0.6518572402952317;0.6523037226692873;1.1998172427475082;yhbV;peptidase U32 family protein YhbV;COG0826;23S rRNA C2501 and tRNA U34 5'-hydroxylation protein RlhA/YrrN/YrrO, U32 peptidase family;RlhA;HELO_RS03360;J;yhbV; peptidase U32 family protein YhbV;;yhbV;peptidase U32 family protein YhbV;0.002433859439887165;-0.06632612303842844;0.2710980445809352;-0.442373793185473;-0.44480765262536015
HELO_1636;2.721402813453578;2.1815168545283847;3.3912895498328144;2.683607947765584;3.7711324711978675;3.457306656806804;0.42455528238741813;0.4616872518548675;0.8178644205990688;0.27860080576737833;0.3082042250589713;0.5449621284463522;HELO_1636;peptidase U32 family protein;COG0826;23S rRNA C2501 and tRNA U34 5'-hydroxylation protein RlhA/YrrN/YrrO, U32 peptidase family;RlhA;HELO_RS03365;J;;yhbV;;HELO_1636;peptidase U32 family protein;0.22613179515606197;-0.021527554842004637;0.09815952364218372;-0.2603256602333386;-0.48645745538940055
HELO_1637;1.4974432773698316;0.9054728819091888;0.6067593282781707;1.0479153101778074;0.7628615670997824;0.5097469004551335;0.25867857810340333;0.27646013539557723;0.2459754658547876;0.5182037095093676;0.28130690134664377;0.2819956299082487;HELO_1637;radical SAM domain protein;COG1180;Pyruvate-formate lyase-activating enzyme;PflA;HELO_RS03370;O;;;1.97.1.4;HELO_1637;radical SAM domain protein;0.3903028351824832;0.08984713708002501;0.22361247694676367;0.7261452003989688;0.3358423652164856
HELO_1638;1.4065124265646844;0.17230501186441746;0.2706825734554867;0.0;0.0;0.5023906384990608;0.5371297411206807;0.14931289739096862;0.24254722157210737;0.0;0.0;0.5662690179034489;HELO_1638;uncharacterized protein;;;;;;;;;HELO_1638;uncharacterized protein;1.037595892101642;-0.2416562998661692;-0.5872599785988287;0.6796838944014251;-0.35791199770021687
HELO_1639;1.3199155177298383;0.26974960375794926;0.3442178276486121;0.48713858677624683;0.4069096748554817;0.288192700890336;0.03840883174726502;0.0685464437992931;0.16744873609562663;0.27576868111522224;0.10990789521185283;0.11967294175777397;HELO_1639;NrdD domain protein;COG1328;Anaerobic ribonucleoside-triphosphate reductase;NrdD;HELO_RS03380;F;;;1.1.98.6;HELO_1639;NrdD domain protein;0.8695282452430246;0.061418520224605644;0.12718128643472904;0.8487238464773073;-0.020804398765717436
HELO_1640;17.254160998715786;5.990766795569447;11.032639914599775;14.541171699686865;10.412499792964534;9.459880253289887;1.5404575835168584;0.658774758708391;2.9152040901186824;1.2091566569765766;1.920861621195605;0.25757423544377206;HELO_1640;YhbT family protein;COG3154;Ubiquinone biosynthesis accessory factor UbiT, lipid carrier SCP2 domain;UbiT;HELO_RS03385;H;;;;HELO_1640;YhbT family protein;1.3847027467218962;0.20208686351531213;0.12574849860682313;0.8033590254370719;-0.5813437212848243
HELO_1641;43.63988243173082;8.597145049451319;25.83736170769402;31.73044460278184;24.199423779078046;19.974997517042848;2.9373206458297743;0.662208598862095;1.8386528692996906;7.115461878667501;3.958287138412308;1.5056676172561683;HELO_1641;uncharacterized protein;;;;;;;;;HELO_1641;uncharacterized protein;2.217656024464785;0.355572212045721;0.2647201049304364;1.0896625876561554;-1.1279934368086297
HELO_1642;43.002940811744715;43.42823822358009;39.78035757698376;40.23215575110421;45.51917479434538;41.524483929966195;0.3701287955100926;2.059800968785125;1.5114709680781375;1.0764359392577618;2.9507023109200543;1.7941734249560122;HELO_1642;SDF family transport protein;COG1301;Na+/H+-dicarboxylate symporter;GltP;HELO_RS03395;C;;;;HELO_1642;SDF family transport protein;-0.013876987830882648;-0.060419302204893555;0.12953177731949417;0.049306217714316425;0.06318320554519907
HELO_1643;227.77178044743155;146.70410230077204;159.13066039147847;143.76471375966625;179.27162475316945;163.75020940713696;13.360906160319999;9.743871076746256;8.817283112902437;6.170581215262793;17.69953190344437;10.676792271120735;yghU;disulfide-bond oxidoreductase YghU;COG0625;Glutathione S-transferase;GstA;HELO_RS03400;O;yghU; disulfide-bond oxidoreductase YghU;1.8.4.-;yghU;disulfide-bond oxidoreductase YghU;0.6311992074185708;-0.04103073029461335;0.12989203151045547;0.4736288041836598;-0.157570403234911
HELO_1644;2669.675467835606;1034.9142726007824;3452.217809901893;2871.153614592396;1414.4745875561111;2844.9343265666503;537.90787071712;363.09130303800737;357.10331790150434;543.2328225605679;171.14148545949777;162.226917575162;cspA1;cold shock protein CspA;COG1278;Cold shock protein, CspA family;CspC;HELO_RS03405;K;cspA1; cold shock protein CspA;;cspA1;cold shock protein CspA;1.3663000575166198;0.27903896400731476;-1.0076165219515794;-0.09169769547072981;-1.4579977529873496
HELO_1645;9.75761865376036;1.820191889312399;4.274379989767862;4.622669648386159;4.145511232835864;3.992571907578737;1.0175684988415092;0.1782456860510105;0.9034850629586274;1.2013942128710486;0.77934009300117;0.43492451435789775;HELO_1645;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS03410;K;;cspA1;;HELO_1645;AraC family transcription regulator;1.9314935191132696;0.07921830627717164;0.04353121653528591;1.1075036409856844;-0.8239898781275852
HELO_1646;23.551477348173407;7.657474056738619;15.803878300765655;22.0590299081496;20.875572165741175;17.530134972270094;3.334545128281566;1.0597139749245528;1.3729992738487415;2.1512486582180093;2.8526023805985297;2.0330219778242165;HELO_1646;UPF0721 family protein;;;;;;;;;HELO_1646;UPF0721 family protein;1.5037917748373673;-0.141079147397007;0.23944736189859217;0.40593644925513495;-1.0978553255822323
HELO_1647;65.81131464294552;30.49677211763041;57.563219846198514;55.31745559994576;56.654666974784824;58.238034232989186;0.4170447204262866;1.7146893615315455;7.466015891926388;0.1223626644711079;3.397334837656408;0.8648458802907633;ldcA;murein tetrapeptide carboxypeptidase;COG1619;Muramoyltetrapeptide carboxypeptidase LdcA (peptidoglycan recycling);LdcA;HELO_RS03420;M;ldcA; murein tetrapeptide carboxypeptidase;3.4.17.13;ldcA;murein tetrapeptide carboxypeptidase;1.0848884624322777;-0.016528890564110554;-0.039086372233741784;0.17356868023079386;-0.9113197822014838
HELO_1648;20.212925572924814;7.469700727462848;16.35285258560228;13.366544565932779;13.987607418404798;16.27129322029693;1.643612664813498;0.3037621459997089;1.0927177967975323;1.124372134282628;0.5498432816472201;1.7135227581108288;argP;LysR family transcription regulator ArgP;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS03430;K;argP; LysR family transcription regulator ArgP;;argP;LysR family transcription regulator ArgP;1.3245607046722205;0.006796731399722589;-0.20460601770778775;0.29656749195896026;-1.0279932127132603
HELO_1649;13.327595179609574;3.388027152635185;5.461107478268036;7.589178278672587;6.744930049413749;6.2662604133362905;0.8226593526641699;0.34624076226900957;0.4844471667965177;0.6748012217839668;0.6064719207237689;1.2967418700941884;argO;LysE family arginine export protein ArgO;COG1279;Arginine exporter protein ArgO;ArgO;HELO_RS03435;E;argO; LysE family arginine export protein ArgO;;argO;LysE family arginine export protein ArgO;1.7071521221276522;-0.16943159702710187;0.09203913795768903;0.9795115041399987;-0.7276406179876536
HELO_1650;192.13405273302783;194.91728984355768;365.73472768667784;493.5458959794551;523.7829004902915;359.3366391686224;5.748037172980258;22.54120897370594;27.754418236885098;18.19079256316841;31.37287217666326;23.158675940102338;HELO_1650;DUF4399 family protein;;;;;;;;;HELO_1650;DUF4399 family protein;-0.020642164360159754;0.025391534496817414;0.5423753589794682;-0.8997427952599857;-0.8791006308998259
HELO_1651;426.6749923028588;212.6512166484387;262.6663404066606;333.02546775368086;299.27020821251296;220.8043194445545;22.063936856624654;18.95714506919562;21.98492197934788;35.17214320098143;33.36060780626263;11.426036074416269;HELO_1651;DUF306 domain protein;COG3187;Heat shock protein HslJ;HslJ;HELO_RS03445;O;;;;HELO_1651;DUF306 domain protein;1.0012573175578527;0.24942594779754934;0.4369738817130564;0.9472273891118306;-0.05402992844602217
HELO_1652;426.3303422875435;188.19109066182273;333.26206641268976;202.46459771856334;295.3789307476861;303.6499267788094;22.83242427627851;3.122184025849227;34.19526132151551;16.131092219728316;30.00269926013226;28.610796290986713;HELO_1652;PmpR family transcription regulator;COG0217;Transcriptional and/or translational regulatory protein YebC/TACO1;TACO1;HELO_RS03450;JK;;;;HELO_1652;PmpR family transcription regulator;1.1755076069398234;0.1338272470061952;-0.03970950192542588;0.48819936458276025;-0.6873082423570631
HELO_1653;62.827578122881995;13.11726750528887;29.179945740995795;37.33402924576569;35.47679264178198;25.317280462008274;1.7279931294822188;0.8970933909761488;2.089567931944484;3.7117300903295516;3.6837561856694285;3.0113085456150555;HELO_1653;peptidase M24 family protein;COG0006;Xaa-Pro aminopeptidase;PepP;HELO_RS03455;E;;;3.4.13.9;HELO_1653;peptidase M24 family protein;2.1767190351000423;0.197579798527018;0.4709684671389205;1.2781694935414647;-0.8985495415585776
HELO_1654;39.69326541409661;10.898133041192002;20.975743360282603;24.91477192244173;19.45080834019908;17.858724360220556;1.410559316168181;0.3608516729541646;0.3398494991210094;2.569809463854435;1.289055592086836;1.3752174771765757;HELO_1654;ABC-type transport system ATP-binding/permease protein;COG1132;ABC-type multidrug transport system, ATPase and permease component;MdlB;HELO_RS03460;V;;;;HELO_1654;ABC-type transport system ATP-binding/permease protein;1.7740548382638877;0.22067987468095485;0.11692577567496887;1.1095579608256143;-0.6644968774382733
HELO_1655;43.722478953249144;10.451318521010505;8.194263677300082;9.706397452226472;10.095062906550895;9.28948108572583;3.430586546597439;1.1329963002939563;1.8575080117349014;2.2565910439441765;1.7564501402510415;1.5735389581888772;HELO_1655;RutC family protein;COG0251;Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family;RidA;HELO_RS03465;V;;;;HELO_1655;RutC family protein;1.965486436706037;-0.16236428061914854;0.10874762057146814;2.119829931791549;0.15434349508551204
HELO_1656;102.63654014588872;35.429739002163835;36.03639362696186;47.95774579453877;40.94475215474921;35.21864340027799;8.032209641679463;5.501416196431991;0.22466482100336663;1.4345512631980364;6.286218174309717;3.8543934792579315;HELO_1656;YrhK domain protein;;;;;;;;;HELO_1656;YrhK domain protein;1.5083441936197932;0.03221111484633887;0.21175781171127994;1.516728342723792;0.008384149103998872
HELO_1657;332.2407605045617;162.45310168273357;319.8956230208158;393.98920026437145;292.18656738600765;297.75030030602676;6.867522027294264;12.388853543685924;8.088218996636618;14.793336999134324;5.229079908548634;24.74991781739124;HELO_1657;OmlA domain protein;COG2913;Outer membrane protein assembly factor BamE, lipoprotein component of the BamABCDE complex;BamE;HELO_RS03475;M;;;;HELO_1657;OmlA domain protein;1.0276881215204732;0.1031639482585085;-0.02712115672487947;0.15762471213524698;-0.8700634093852262
HELO_1658;13.110359680460691;4.155114031541776;11.451024538060901;14.739336438737473;9.534040366650018;10.614581485856435;0.15909535877324887;0.09062179440702492;0.8809280207138165;0.4398112746047528;1.327435397004014;1.645750804206812;HELO_1658;sensor histidine kinase;COG4252;Extracytoplasmic sensor domain CHASE2 (specificity unknown);CHASE2;HELO_RS03480;T;;;;HELO_1658;sensor histidine kinase;1.4526785178656585;0.10032729026085407;-0.1408782766655543;0.2808175937398687;-1.1718609241257898
HELO_1659;25.23324564790192;11.882009651249405;34.250935813591106;44.845162147551406;25.256009505085554;29.285758855430515;1.810177819559569;0.10873779162259721;2.4425489025268905;3.983454668956844;5.43265272896462;4.916411262666278;HELO_1659;LysM domain protein;COG4254;Uncharacterized peptidoglycan binding protein, contains LysM and FecR  domains;;HELO_RS03485;R;;;;HELO_1659;LysM domain protein;1.0260386348637036;0.2190219967847975;-0.20599189450417388;-0.20724324797960758;-1.2332818828433112
HELO_1660;60.84565508613645;10.229083861237308;30.33899560571925;31.44572382713692;63.4333337678378;32.90611850039712;8.17167334469197;0.9518408060029452;5.759371764135344;2.0982233066520894;26.977922050367532;9.218828306397302;HELO_1660;YadA domain protein;COG5295;Autotransporter adhesin;Hia;HELO_RS03490;WU;;;;HELO_1660;YadA domain protein;2.4614320149776905;-0.113586694066794;0.9262616042569523;0.8671266062623415;-1.594305408715349
HELO_1661;166.67089078698226;61.555123603998084;167.79870542609703;316.3413374600264;141.0316490531961;120.21752851816854;9.619510485160557;2.5089849022160706;22.22663291117403;28.407850428139312;55.67635513067562;32.851400247070096;HELO_1661;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS03495;KT;;;;HELO_1661;response regulator/HTH domain transcription regulator;1.4224322865827093;0.4777055064594693;0.22861410960357187;0.46803391236087055;-0.9543983742218387
HELO_1662;149.0664024308477;44.6787023155249;80.18924590435809;106.61388220289997;71.95441813809408;69.0426027759212;10.04401068361451;3.649081172301815;12.403981312106644;4.90861150877004;9.689603694993087;9.688015309160653;npd;probable 2-nitropropane dioxygenase;COG2070;NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family;YrpB;HELO_RS03500;R;npd; probable 2-nitropropane dioxygenase;1.13.12.16;npd;probable 2-nitropropane dioxygenase;1.7160074448579898;0.21305594963338237;0.05876265559995808;1.0992964155066476;-0.6167110293513423
HELO_1663;30.82607696589389;8.853685484219278;6.62061357377761;17.35178754173513;6.17091932405548;6.032111841784307;2.4169444258281976;1.4220193300118915;0.4542156807612225;4.383174127076972;0.28168088492682275;1.719064421135659;ibpA;small heat shock protein IbpA;COG0071;Small heat shock protein IbpA, HSP20 family;IbpA;HELO_RS03505;O;ibpA; small heat shock protein IbpA;;ibpA;small heat shock protein IbpA;1.6914740057574456;0.11594914508355103;0.02820007082527054;2.1781794134288806;0.486705407671435
HELO_1664;151.22323479618015;32.36375518563127;89.57790138761932;117.30368221977731;96.30197876146872;83.80763512019352;2.5459639299530528;0.466217827198616;5.868775732659998;10.080957056005724;9.43583975349613;8.288481915722976;HELO_1664;integrase family protein;COG4973;Site-specific recombinase XerC;XerC;HELO_RS03510;L;;;;HELO_1664;integrase family protein;2.189835000859846;0.09496495918865211;0.19827498979418312;0.8439225236369889;-1.345912477222857
HELO_1665;52.249181068221105;10.010047059049848;3.671473869019945;3.7261179333793137;6.0085455847280045;3.4459622629545255;4.172614351020562;2.12743029069111;0.6338612849461025;1.0826464959083055;0.44477556258698664;1.0063254067315046;HELO_1665;uncharacterized protein;;;;;;;;;HELO_1665;uncharacterized protein;2.27393870268967;0.07138209499965953;0.6566193839188452;3.582191729934469;1.3082530272447994
HELO_1666;5.187090978383194;1.5991578205295263;2.605238284529445;3.080228716581667;2.8741495488680404;2.2512087463322823;0.5754195714833427;0.2681201018359991;0.8074561339174346;0.5059198780794286;0.5416331746102855;0.23854618872649874;HELO_1666;DUF3631 family protein;;;;;;;;;HELO_1666;DUF3631 family protein;1.2512170115599968;0.14911842773220374;0.25290345720266716;0.9282850599523147;-0.32293195160768207
HELO_1667;51.188457929906015;14.741527958921251;26.18940919411685;26.58261465323919;30.84905788966206;29.089024056769862;4.882849251772371;1.682358917506302;4.315932455640301;7.487087198079676;3.155953595806579;5.035850059203303;HELO_1667;uncharacterized protein;;;;;;;;;HELO_1667;uncharacterized protein;1.7291551901574462;-0.14619251034139147;0.08201338416315895;0.7944934603405329;-0.9346617298169133
HELO_1668;13.564951732964575;12.7628518081701;11.514218090403338;9.169233259072039;15.153419184898999;13.105140802644557;0.9505619812523645;0.9327096186321534;1.5932800811771362;0.6234013654923187;0.4695825706894495;1.9174784856587248;HELO_1668;GcvT family protein;COG0404;Glycine cleavage system protein T (aminomethyltransferase);GcvT;HELO_RS03560;E;;;;HELO_1668;GcvT family protein;0.08172147785789274;-0.17265291569562358;0.19561850416624527;0.046279853013256655;-0.03544162484463609
HELO_1669;81.49449119520095;73.57309306904358;102.47822958422925;87.29312400268402;110.05484131040403;101.88112529321488;2.945028306114615;3.7893054667989303;5.699715076849221;2.506726770013714;7.279364112730663;0.8125635457006155;tesB;acyl-CoA thioesterase 2;COG1946;Acyl-CoA thioesterase;TesB;HELO_RS03565;I;tesB; acyl-CoA thioesterase 2;3.1.2.-;tesB;acyl-CoA thioesterase 2;0.14564260105721694;0.008348948407793877;0.1102939591418064;-0.3186086401613135;-0.46425124121853045
HELO_1670;82.74655400798655;36.81350167866703;100.80403542944373;119.56526751264964;122.51315484370154;99.21685996921927;8.231258439658266;4.277048808832292;7.981768036544014;8.997883834217369;3.8991603001332784;1.825039149968248;tadA;tRNA-specific adenosine deaminase;COG0590;tRNA(Arg) A34 adenosine deaminase TadA;TadA;HELO_RS03570;J;tadA; tRNA-specific adenosine deaminase;3.5.4.33;tadA;tRNA-specific adenosine deaminase;1.147128373121773;0.022669509261844745;0.3015394645589424;-0.25902350757825143;-1.4061518807000244
HELO_1671;79.63562956391367;41.21561748441298;68.10093669172703;58.4215597088941;60.408364853538764;62.81272375673698;0.5709810288787379;1.938694967711077;5.860405343205057;5.796700455215634;2.192345512767594;2.4347633504802766;mltF;lytic murein transglycosylase MltF;COG4623;Membrane-bound lytic murein transglycosylase MltF;MltF;HELO_RS03575;TM;mltF; lytic murein transglycosylase MltF;4.2.2.-;mltF;lytic murein transglycosylase MltF;0.9336406307072691;0.11486115232185146;-0.05540892640729034;0.33757333240343357;-0.5960672983038355
HELO_1672;355.39732027774284;340.8789254034801;424.2764249546294;413.9999459893501;456.80565479567684;435.3700019466981;11.20810673810787;3.358912977745323;18.336569058141592;12.096120002232393;25.593233377887582;19.01286033925367;purL;phosphoribosylformylglycinamidine synthase;COG0047;Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain;PurL2;HELO_RS03580;F;purL; phosphoribosylformylglycinamidine synthase;6.3.5.3;purL;phosphoribosylformylglycinamidine synthase;0.06000099658246327;-0.03715104576858863;0.06918335544133569;-0.29206543827438125;-0.3520664348568445
HELO_1673;84.13577727378085;66.69814851874344;76.55569647724943;72.23974327046038;67.7277291861199;78.71205625001164;5.510756102415264;0.8658401988755307;4.414210804623703;2.1037085457046065;3.5294078984059154;8.020535160840934;HELO_1673;helicase domain protein;COG1061;Superfamily II DNA or RNA helicase;SSL2;HELO_RS03590;KL;;purL;;HELO_1673;helicase domain protein;0.3306491563861149;-0.03956519343627374;-0.21390565228757996;0.09496758961017271;-0.2356815667759422
HELO_1674;86.83178890968345;48.44097998394968;68.05207426658308;74.22484219156301;66.22899337478857;65.37068136975257;5.449960931115625;2.252321312112471;8.256784644553795;0.6532237645450376;2.857121897728822;9.041518094109149;HELO_1674;crotonase domain protein;COG1024;Enoyl-CoA hydratase/carnithine racemase;CaiD;HELO_RS03595;I;;;;HELO_1674;crotonase domain protein;0.8290358484740787;0.0571386672918921;0.018537462945161565;0.4041971028797482;-0.42483874559433055
HELO_1675;119.05264879313226;115.46145903336736;123.60954662534421;132.0853812495859;100.65794454521898;128.7487864128906;5.141529904125767;5.958553338293386;5.804573144395231;3.9766476075892134;6.4527577531091405;11.7182309753156;scpA;segregation and condensation protein ScpA;COG1354;Chromatin segregation and condensation protein Rec8/ScpA/Scc1, kleisin family;ScpA;HELO_RS03600;L;scpA; segregation and condensation protein ScpA;;scpA;segregation and condensation protein ScpA;0.043814636825712405;-0.05830644380292416;-0.351998078722799;-0.1120538096402619;-0.1558684464659743
HELO_1676;127.64916393409118;116.81745403408145;78.28137421917656;75.82945804009691;54.85000706427812;60.62339860099895;4.691078590543914;5.245785915228237;9.927727860370675;17.037229342237495;4.339949431111022;7.391721667287415;scpB;segregation and condensation protein ScpB;COG1386;Chromosome segregation and condensation protein ScpB;ScpB;HELO_RS03605;K;scpB; segregation and condensation protein ScpB;;scpB;segregation and condensation protein ScpB;0.12688879864922598;0.36350371875831566;-0.14192078766478478;1.0618919253399168;0.9350031266906909
HELO_1677;241.31485794815703;257.62401253047875;276.422594901433;312.75411968673797;244.9190520899895;283.6666692589163;9.31389689902955;9.805290520767489;13.510293473865676;31.767255189572687;1.9534051400517505;6.638531963059025;rluB;23S rRNA pseudouridine(2605) synthase RluB;COG1187;Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605;RsuA;HELO_RS03610;J;rluB; 23S rRNA pseudouridine(2605) synthase RluB;5.4.99.22;rluB;23S rRNA pseudouridine(2605) synthase RluB;-0.09397336284136504;-0.037188288383120494;-0.21109007306630634;-0.23239071345750073;-0.1384173506161357
HELO_1678;435.6695986521309;386.2263159652818;394.0294709624491;412.45770622211063;428.7009689968492;363.4108927853131;7.228118693308842;19.411623495900127;5.261675255440379;19.860219702949912;29.78396861855774;26.678019096842828;nadA;quinolinate synthase;COG0379;Quinolinate synthase;NadA;HELO_RS03625;H;nadA; quinolinate synthase;2.5.1.72;nadA;quinolinate synthase;0.17336509108889508;0.11639420470503659;0.23776694637201423;0.260976008737865;0.08761091764896989
HELO_1679;317.52872795571346;322.3856762438972;482.9959940087023;392.74642067308304;423.1364429033744;491.0032245987034;9.864807183477687;8.114472042491451;32.50145595847065;6.596712275582221;4.835296971410703;23.12609934694374;ilvD1;dihydroxy-acid dehydratase;COG0129;Dihydroxyacid dehydratase/phosphogluconate dehydratase;IlvD;HELO_RS03630;GE;ilvD1; dihydroxy-acid dehydratase;4.2.1.9;ilvD1;dihydroxy-acid dehydratase;-0.021832284447414807;-0.023672664554627687;-0.2141393226864885;-0.6272442767122115;-0.6054119922647967
HELO_1680;191.44643133907502;183.06792939025206;277.59221709587086;290.07947792632166;285.24961136111773;268.7644561362088;8.87556924678038;9.222541047115813;22.64754087482974;11.753910469082552;17.832536654244322;6.848769302617253;HELO_1680;GFO family oxidoreductase;COG0673;Predicted dehydrogenase;MviM;HELO_RS03635;R;;ilvD1;;HELO_1680;GFO family oxidoreductase;0.06421863428784835;0.0464546816677327;0.0855734615561694;-0.4872433543663801;-0.5514619886542285
HELO_1681;65.95615734873682;33.423465162502204;110.1374409345064;90.61081987370527;114.47140766749617;121.67234391904826;1.3181545335426537;0.6635825026970876;15.580215279263516;1.3905519766848708;6.779225194476763;5.82930712786083;nudE;ADP compounds hydrolase NudE;COG1051;ADP-ribose pyrophosphatase YjhB, NUDIX family;YjhB;HELO_RS03640;F;nudE; ADP compounds hydrolase NudE;3.6.1.-;nudE;ADP compounds hydrolase NudE;0.9598244027748244;-0.1424651086583646;-0.08727437032417829;-0.8735213964514115;-1.8333457992262359
HELO_1682;197.1800069686451;219.3729391354093;209.2600311749602;239.81714934646365;201.90030854371545;217.55806442113214;4.597803118122868;7.830374017677332;12.122513770974138;5.630919297408292;11.131003263351127;14.046461683451197;HELO_1682;HAD superfamily hydrolase (homolog to GMP/IMP nucleotidase);COG1011;FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis);YigB;HELO_RS03645;H;;nudE;3.1.3.5;HELO_1682;HAD superfamily hydrolase (homolog to GMP/IMP nucleotidase);-0.15313565175082555;-0.05584198127011586;-0.10724555314646711;-0.14120518591380016;0.011930465837025395
HELO_1683;211.40663830882988;196.8565365653077;85.0909899448379;103.87852326714825;85.11601166899582;101.0468690639276;1.3118951091668396;11.292500395784774;3.528945086107344;7.947838701695314;6.9890686841963765;10.82243538827826;hslR;heat shock protein Hsp15;COG1188;Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain;HslR;HELO_RS03650;J;hslR; heat shock protein Hsp15;;hslR;heat shock protein Hsp15;0.10237412689113601;-0.24529775722253433;-0.24487850925615806;1.057596935938367;0.955222809047231
HELO_1684;146.37041675071794;186.90818690526316;195.98226655169674;179.97886666367313;205.12414714410954;203.3187828285136;1.7239684635008086;4.236679651374635;15.946651573140329;7.189400591445846;7.9130172526887605;4.150713732050231;hslO;molecular chaperone HslO;COG1281;Redox-regulated molecular chaperone, HSP33 family;HslO;HELO_RS03655;O;hslO; molecular chaperone HslO;;hslO;molecular chaperone HslO;-0.3505809785968008;-0.05275607970093432;0.0126916886734314;-0.47137488993040755;-0.12079391133360673
HELO_1685;162.6879775308354;148.10633026340227;134.7112521411833;3.853436335287333;1978.8667727616391;131.93532541528455;1.8733555631066312;4.771037326324227;11.479637348525193;0.2509661358616273;223.48837236716963;12.510105250151529;pckA;phosphoenolpyruvate carboxykinase (ATP);COG1866;Phosphoenolpyruvate carboxykinase, ATP-dependent;PckA;HELO_RS03660;C;pckA; phosphoenolpyruvate carboxykinase (ATP);4.1.1.49;pckA;phosphoenolpyruvate carboxykinase (ATP);0.13460685529472194;0.02981581451460613;3.896606919586974;0.3002238349281825;0.16561697963346056
HELO_1686;36.944424181631916;4.043029980887125;16.91696013380016;40.64453639644591;74.60399211772618;14.630889151817236;2.238663785459229;0.5631109750068385;2.051933468182458;1.1248295843927298;5.56054900096934;1.7399742419429447;msrB2;peptide methionine sulfoxide reductase MsrB (R-form specific);COG0229;Peptide methionine sulfoxide reductase MsrB;MsrB;HELO_RS03665;O;msrB2; peptide methionine sulfoxide reductase MsrB (R-form specific);1.8.4.12;msrB2;peptide methionine sulfoxide reductase MsrB (R-form specific);2.9115251942663134;0.19692603716362056;2.27406256775125;1.279488054207707;-1.6320371400586065
HELO_1687;292.85531946186234;215.5431958645677;341.8925958526588;325.47814738590586;289.4881023079727;349.3438311417053;11.18183838789559;0.527239616357496;17.54912777023038;14.662659327214792;25.644947022513115;19.880034251137975;yhgF;Tex family protein YhgF;COG2183;Transcriptional accessory protein Tex/SPT6;Tex;HELO_RS03670;K;yhgF; Tex family protein YhgF;;yhgF;Tex family protein YhgF;0.4404511733651022;-0.031014741252143097;-0.2702924179332413;-0.25366547877930934;-0.6941166521444115
HELO_1688;211.63492364300706;143.405087133444;218.27237108204432;242.51663670884818;206.44839397698868;219.81154387796468;5.59265920688829;4.915443504477796;20.220037385714676;6.109335978407785;18.736513748035797;18.44176721961225;gshA;glutamate--cysteine ligase;COG2918;Gamma-glutamylcysteine synthetase;GshA;HELO_RS03675;H;gshA; glutamate--cysteine ligase;6.3.2.2;gshA;glutamate--cysteine ligase;0.5582570011502046;-0.010091557261736384;-0.09006310900428538;-0.05443702936585204;-0.6126940305160566
HELO_1689;212.44472482910646;123.36413984742927;128.79990109439413;154.49040712706858;125.94675292072561;129.1369115745377;13.52571758169282;4.303192915937087;1.6475074174221167;2.3077528717545177;7.078629259130176;16.218656181955428;dsbB;disulfide bond formation protein DsbB;COG1495;Disulfide bond formation protein DsbB;DsbB;HELO_RS03680;O;dsbB; disulfide bond formation protein DsbB;1.8.5.9;dsbB;disulfide bond formation protein DsbB;0.7792919604135431;-0.0037409370059169333;-0.03580672722785039;0.7138322865676638;-0.06545967384587925
HELO_1690;345.87524723192536;176.87277530564242;333.50087284538216;369.4568683410098;410.54018571950525;333.6819847621012;7.306626098224415;5.183119197588087;35.20922603944207;4.882327226618586;57.64044827071287;21.386238954090214;HELO_1690;AlgQ family protein;COG3160;Regulator of sigma D;Rsd;HELO_RS03685;K;;dsbB;;HELO_1690;AlgQ family protein;0.963571181860309;-0.0007809203941970821;0.2982424167316733;0.0516259987880634;-0.9119451830722456
HELO_1691;27.41222549456144;17.454057710492673;27.809877891086945;32.2124733901038;23.115977212440473;26.814238065977122;1.0553603439456078;0.3560713895694061;1.2498854995399389;0.35575850507814477;2.169683133515905;1.3188822359427406;HELO_1691;HAE1 family transport protein;COG0841;Multidrug efflux pump subunit AcrB;AcrB;HELO_RS03690;V;;;;HELO_1691;HAE1 family transport protein;0.6225737669997553;0.0507399603128329;-0.20583431415870734;0.030688255052829128;-0.5918855119469262
HELO_1692;47.016253585017836;28.465074230005445;59.52456114441069;72.66446969916247;52.7578324487275;62.616983991668945;0.3585507846229342;3.3019500062361233;2.2138349675950506;4.494438353849474;7.714294564818093;5.650867565419531;HELO_1692;RND family transport protein MFP component;COG0845;Multidrug efflux pump subunit AcrA (membrane-fusion protein);AcrA;HELO_RS03695;VM;;;;HELO_1692;RND family transport protein MFP component;0.7045169425681452;-0.07189126350837505;-0.24293700810607533;-0.40588913370208335;-1.1104060762702286
HELO_1693;1516.8999152369709;1023.8283881426654;2040.9963462019612;1280.1575783351918;2968.211626463157;2221.0020038379585;70.44860531243575;86.36739781680583;214.40628056707027;187.2481995691448;162.03820211008312;110.54428353198892;mdh;malate dehydrogenase;COG0039;Malate/lactate dehydrogenase;Mdh;HELO_RS03700;C;mdh; malate dehydrogenase;1.1.1.37;mdh;malate dehydrogenase;0.5666943233041692;-0.12187983300805882;0.4182198053145143;-0.5497834499132956;-1.1164777732174649
HELO_1694;164.16411537191217;174.62135073425716;268.0773431723218;214.8580348446567;188.1923304424837;269.43936733877746;3.4777693145959327;12.682633430632338;11.634219021551484;2.4123646090252904;24.697983486862835;4.323479995310076;HELO_1694;HAD superfamily hydrolase;COG0560;Phosphoserine phosphatase;SerB;HELO_RS03705;E;;mdh;;HELO_1694;HAD superfamily hydrolase;-0.08856797612912981;-0.007284258843839098;-0.5154515719604067;-0.7114049057387808;-0.622836929609651
HELO_1695;213.08390148235344;143.09889125209875;383.4413310281323;354.10951309765454;311.6659568750112;365.35766092863054;14.312308722759827;12.360289232091109;13.644177868797948;18.16841082898428;15.22369811415268;16.68776897292663;rppH;RNA pyrophosphohydrolase;COG0494;8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family;MutT;HELO_RS03710;V;rppH; RNA pyrophosphohydrolase;3.6.1.-;rppH;RNA pyrophosphohydrolase;0.5711170781740176;0.06951066333865086;-0.22863063736043898;-0.7750764711588332;-1.3461935493328507
HELO_1696;174.64974776736344;153.57482090915673;235.18338809144157;282.13325086793986;261.98272106587154;224.9865061815681;5.339739637736702;9.215072183191536;8.058683564912661;7.353324221285401;10.03275903502336;1.4193271371026286;ptsP;phosphoenolpyruvate-protein phosphotransferase PtsP;COG3605;Signal transduction protein containing GAF and PtsI domains;PtsP;HELO_RS03715;T;ptsP; phosphoenolpyruvate-protein phosphotransferase PtsP;2.7.3.9;ptsP;phosphoenolpyruvate-protein phosphotransferase PtsP;0.18439617076642278;0.06367086580995363;0.21873138140609694;-0.3635351259884345;-0.5479312967548573
HELO_1697;60.663996056513355;30.100810046207922;62.05946486727657;69.06721377476873;68.2554650719133;63.84785502038962;3.3376215720979747;2.3468013635032854;7.560761047179509;2.099390611988496;7.974290376526379;5.179801350158743;HELO_1697;DUF833 domain protein;COG3332;Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif;Tango2;HELO_RS03720;R;;ptsP;;HELO_1697;DUF833 domain protein;0.9874762274586137;-0.04034592795223446;0.0948690662011824;-0.0726304705999441;-1.0601066980585578
HELO_1698;151.27102529448348;119.42071217412507;145.3139128663545;182.28501582400543;131.64230591959043;126.61933737559433;6.361161919969442;3.4794335463472073;14.066824133390497;20.056975940936766;9.320658591532348;11.056914831592543;HELO_1698;response regulator domain protein;COG0784;CheY-like REC (receiver) domain, includes chemotaxis protein CheY  and sporulation regulator Spo0F;CheY;HELO_RS03725;T;;;;HELO_1698;response regulator domain protein;0.33855789175151685;0.19722001225296193;0.05569404429122482;0.25479449808307475;-0.0837633936684421
HELO_1699;230.22275624262215;116.15805667258034;130.59604117064458;170.4689218236597;138.4150981773393;123.83894881145942;12.685682657579498;6.965456631114589;12.916396914731955;15.19918377856949;5.340982070858519;13.744497069950585;HELO_1699;UPF0721 family protein;COG0730;Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family;TauE;HELO_RS03730;P;;;;HELO_1699;UPF0721 family protein;0.9808272222812082;0.07604797443651368;0.15931869418230526;0.8892152760844079;-0.09161194619680035
HELO_1700;126.8168347523182;41.26721412028448;97.17402189264777;104.32496603777865;109.0039604866882;92.68190520416177;4.456407298716953;3.0588919866290785;6.281900922665965;7.483615935959067;13.371331274243092;14.700778465661116;lgt;prolipoprotein diacylglyceryltransferase;COG0682;Prolipoprotein diacylglyceryltransferase;Lgt;HELO_RS03735;M;lgt; prolipoprotein diacylglyceryltransferase;2.5.1.145;lgt;prolipoprotein diacylglyceryltransferase;1.5964669351707608;0.06757090324540993;0.2317131449533516;0.4482355448636186;-1.1482313903071422
HELO_1701;249.24927889122986;191.80385775406748;239.44998404904536;235.3244789229076;189.6050052355457;225.75767681072446;3.881894620142604;13.33274958329084;15.297517110874649;5.489339246630395;3.7365346047108057;9.340353125268665;thyA;thymidylate synthase;COG0207;Thymidylate synthase;ThyA;HELO_RS03740;F;thyA; thymidylate synthase;2.1.1.45;thyA;thymidylate synthase;0.3762319935469627;0.0845854369350807;-0.2505653890488455;0.14221451827916098;-0.2340174752678017
HELO_1702;226.70301064502132;181.16878330486392;135.59409173790814;141.97754222186038;115.26461445786158;132.9828461005675;13.119489185997159;16.927572877221333;7.326286995818974;3.3419769153244765;3.6245129375315766;3.730785204174409;folA;dihydrofolate reductase;COG0262;Dihydrofolate reductase;FolA;HELO_RS03745;H;folA; dihydrofolate reductase;1.5.1.3;folA;dihydrofolate reductase;0.32187760853613323;0.027846778976217124;-0.20463622911153045;0.7651050631889014;0.44322745465276814
HELO_1703;570.9754482798372;423.83174416036854;631.3862793134908;680.7460600693117;640.4151506893623;623.0634960464081;20.257128813035592;11.94145785206147;69.25494898872533;47.67423439811827;80.68255128759203;49.188191025877856;HELO_1703;ProQ_Cterm domain protein;COG3109;sRNA-binding protein ProQ;ProQ;HELO_RS03750;T;;folA;;HELO_1703;ProQ_Cterm domain protein;0.4290616506396674;0.019113241139933734;0.03956560648675378;-0.12573960372443516;-0.5548012543641025
HELO_1704;37106.892241991554;55370.08135429341;51408.59119368182;53379.02821862916;57289.349791087814;59438.25238937533;1152.0975733148216;2041.5798547034467;3528.417757826541;2807.556104691751;4973.563925128749;5621.835655193206;hopP;monosaccharide porin;COG3203;Outer membrane porin OmpC/OmpF/PhoE;OmpC;HELO_RS03755;M;hopP; monosaccharide porin;;hopP;monosaccharide porin;-0.5774066397306381;-0.20937843026774594;-0.05312382387394621;-0.6796899130393186;-0.10228327330868048
HELO_1705;366.21563648537887;387.5264369470679;723.0639576104137;618.5390243624128;868.7771794273964;717.3605477984034;7.438575586734218;21.512339115275022;19.49621687231088;32.98137041654742;60.26891735318304;37.88820546072507;HELO_1705;uncharacterized protein;;;;;;;;;HELO_1705;uncharacterized protein;-0.08138527715835409;0.0114090185005562;0.2759377371655791;-0.9680806280065379;-0.8866953508481838
HELO_1706;134.52375362223086;172.4992021710913;256.64554380762917;223.6955549583752;248.4683230745038;242.3579439968145;8.966571643700766;12.91923427231874;5.844354166032007;7.219921527585302;5.041377310589468;1.0529887557919573;HELO_1706;diguanylate cyclase;COG2202;PAS domain;PAS;HELO_RS03765;T;;;;HELO_1706;diguanylate cyclase;-0.3563832897629018;0.08230777044957716;0.03577676737140845;-0.8445341307730647;-0.48815084101016293
HELO_1707;129.76331035737934;105.88520503081229;128.17893684219226;147.56895149144296;124.91822265429418;139.12545445550208;7.346363256095848;8.737861971369039;4.088468284677835;9.067246648550588;1.853269393247677;8.467442370820134;cmoM;tRNA cmo(5)U methyltransferase CmoM;COG2227;2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase;UbiG;HELO_RS03775;H;cmoM; tRNA cmo(5)U methyltransferase CmoM;;cmoM;tRNA cmo(5)U methyltransferase CmoM;0.2908956353114416;-0.11734820015498215;-0.15423196964655705;-0.09976124655950969;-0.39065688187095127
HELO_1708;114.06726572841119;91.78132374552955;112.57503904324396;151.10270907988152;110.93483709687087;114.26836569232982;6.089285408594369;1.4059880986472182;8.261264054295951;4.429317346225257;5.289930370342933;12.41724246722984;rsmC;16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;COG2813;16S rRNA G1207 or 23S rRNA G1835 methylase RsmC/RlmG;RsmC;HELO_RS03780;J;rsmC; 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;2.1.1.172;rsmC;16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;0.31057113984393325;-0.02135083202025978;-0.042337522116713266;-0.002519158608642158;-0.3130902984525754
HELO_1709;36.56371024535189;40.41915122638852;27.00447397511618;25.028286718950962;28.10350103201232;28.559233248920734;4.465140747545616;3.094093809607122;1.6047292665606447;1.3980681715539565;2.296895812763601;4.152928734090767;greB;transcription elongation factor GreB;COG0782;Transcription elongation factor, GreA/GreB family;GreA;HELO_RS03785;K;greB; transcription elongation factor GreB;;greB;transcription elongation factor GreB;-0.14095842172128759;-0.07795151768239528;-0.022416133333689636;0.3457307207893887;0.4866891425106763
HELO_1710;61.04976380160442;24.681018408438106;77.76935554645861;86.72990391135609;73.33988799672072;76.18386370273153;0.06357374467616833;0.5148480946290069;4.7464520906094165;3.652944568546882;7.594883508303007;8.023976292140441;HELO_1710;TPR domain protein;COG3063;Type IV pilus assembly protein PilF/PilW;PilF;HELO_RS03790;NW;;greB;;HELO_1710;TPR domain protein;1.2727233033886431;0.02933520759281283;-0.05416275014725258;-0.31487354612118246;-1.5875968495098256
HELO_1711;227.41067338943108;115.0175716782768;138.73067359148425;141.10290319412704;126.81453813474907;123.34963327346236;18.785373262866095;9.13845282649657;7.453446182162375;30.202749182042474;10.295742314053422;14.530063972893377;nudF;ADP-ribose pyrophosphatase;COG0494;8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family;MutT;HELO_RS03795;V;nudF; ADP-ribose pyrophosphatase;3.6.1.13;nudF;ADP-ribose pyrophosphatase;0.9772867396651517;0.168246502213389;0.03964969067194257;0.8772278150633204;-0.1000589246018313
HELO_1712;204.73281564781632;103.0698259162462;69.07724777904492;71.55527228747253;79.72978427595136;73.66942465188295;12.861727505643346;3.7973829624980895;8.650164378447698;10.181295758122857;9.730084233707702;13.110051580615666;HELO_1712;DUF1249 family protein;COG3151;Uncharacterized conserved protein YqiB, DUF1249 family;yqiB;HELO_RS03800;S;;nudF;;HELO_1712;DUF1249 family protein;0.9832200977595225;-0.09157149922738661;0.11258342184478298;1.462182411098305;0.4789623133387826
HELO_1713;219.6729725442333;122.62134876702804;115.57582186834317;129.64624169215054;124.26007886147589;112.74004774117081;7.503045408711481;4.565473311874614;3.1892001040004336;6.361747204176032;6.580365908987556;3.3142376686347292;cpdA;3'%2C5'-cyclic adenosine monophosphate phosphodiesterase CpdA;COG1409;3',5'-cyclic AMP phosphodiesterase CpdA;CpdA;HELO_RS03805;T;cpdA; 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA;3.1.4.53;cpdA;3'%2C5'-cyclic adenosine monophosphate phosphodiesterase CpdA;0.8359820321510929;0.03552828586384127;0.1391863773915114;0.956169627915922;0.12018759576482907
HELO_1714;335.0353966836529;817.9494428555785;730.4995090302372;396.7639494212743;495.98172168545966;690.1674149590535;29.722138842623874;47.39946739321283;133.12135112815406;21.194010622273098;59.737318673036064;91.13480689549692;cysD1;sulfate adenylyltransferase subunit 2;COG0175;Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme;CysH;HELO_RS03810;EH;cysD1; sulfate adenylyltransferase subunit 2;2.7.7.4;cysD1;sulfate adenylyltransferase subunit 2;-1.2851611820820477;0.08182169270755857;-0.4758424109508095;-1.0404219943576258;0.24473918772442183
HELO_1715;390.81422226897365;807.6731067389487;565.6381518330766;363.78612929964703;333.83176981131555;600.4439275763251;17.999480017986027;37.569029411060015;54.63703255051652;28.17694193820263;5.832961266083912;18.29244697266468;cysN1;sulfate adenylyltransferase subunit 1;COG2895;Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family;CysN;HELO_RS03820;P;cysN1; sulfate adenylyltransferase subunit 1;2.7.7.4;cysN1;sulfate adenylyltransferase subunit 1;-1.0453868677128018;-0.08600249981356356;-0.8449938201960716;-0.6182604754532353;0.4271263922595665
HELO_1716;141.73592922385703;117.78813710057905;95.67825015475961;97.76163337638589;90.43050082563457;93.09145349694978;6.596040477227602;5.29465629084439;2.103103546182934;2.338612226703158;3.6126207943692252;0.9087354077430212;cmoB;tRNA U34 carboxymethyltransferase CmoB;COG2227;2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase;UbiG;HELO_RS03825;H;cmoB; tRNA U34 carboxymethyltransferase CmoB;2.1.1.-;cmoB;tRNA U34 carboxymethyltransferase CmoB;0.2649577659431488;0.03912767481279378;-0.041388163712912984;0.6012129417289023;0.3362551757857535
HELO_1717;134.800397263411;99.52113750039643;89.91008447071329;110.90802718435668;93.09502527033993;101.91576124016005;6.706275644476384;6.50896680676215;2.2049823605360914;7.323846951207063;7.244297141504754;3.7569475329479083;cmoA;carboxy-S-adenosyl-L-methionine synthase;COG4106;Trans-aconitate methyltransferase;Tam;HELO_RS03830;C;cmoA; carboxy-S-adenosyl-L-methionine synthase;2.1.1.-;cmoA;carboxy-S-adenosyl-L-methionine synthase;0.43398879796711753;-0.17895169993596927;-0.12927358763511876;0.4000237564032165;-0.03396504156390101
HELO_1718;369.4580710193129;222.17341905455783;537.8879574192264;504.62511187023034;428.4010518556088;508.962393602254;16.639978222847244;9.054357047012672;9.47071592412896;24.6580048389489;77.45112456433519;72.74129685884124;pgi2;glucose-6-phosphate isomerase;COG0166;Glucose-6-phosphate isomerase;Pgi;HELO_RS03835;G;pgi2; glucose-6-phosphate isomerase;5.3.1.9;pgi2;glucose-6-phosphate isomerase;0.7311450594459101;0.07959448537906333;-0.24806513645534523;-0.46108059620664754;-1.1922256556525577
HELO_1719;607.6695832438213;434.85543012747394;603.4090714458101;553.7722168018763;463.96543802732475;530.0670043594328;12.359079451174471;3.6111675626635247;41.29921260297283;63.120042875389046;79.12893412032139;76.27605996274592;yqiA;esterase YqiA;COG3150;Predicted esterase YcpF, UPF0227 family;YcfP;HELO_RS03840;R;yqiA; esterase YqiA;;yqiA;esterase YqiA;0.4818095889336025;0.18663141740854172;-0.19177041505987802;0.1967653761461552;-0.2850442127874473
HELO_1720;258.18735299205156;317.557987183031;351.6671367300176;309.9332521675256;292.60204393111724;338.6296198484241;8.794041094593931;6.4752858020107515;12.546444849254765;10.909551860639935;32.64821663507861;23.845082679080875;parE;DNA topoisomerase 4 subunit B;COG0187;DNA gyrase/topoisomerase IV, subunit B;GyrB;HELO_RS03845;L;parE; DNA topoisomerase 4 subunit B;5.6.2.2;parE;DNA topoisomerase 4 subunit B;-0.2975606866413276;0.054344859565189196;-0.21010027335686132;-0.38996696114295126;-0.09240627450162364
HELO_1721;243.13843858400642;259.1310364673198;257.36858372657315;245.74345528796803;251.31047777819822;254.49050873620106;7.305554084759625;14.799642750095153;9.62964249978393;4.42627463649971;16.505355269877725;8.649850277242834;parC;DNA topoisomerase 4 subunit A;COG0188;DNA gyrase/topoisomerase IV, subunit A;GyrA;HELO_RS03850;L;parC; DNA topoisomerase 4 subunit A;5.6.2.2;parC;DNA topoisomerase 4 subunit A;-0.09153907943998796;0.016160959281668497;-0.01806957839725687;-0.06557023786580096;0.025968841574186996
HELO_1722;225.20513628673564;205.93081585650052;185.34955631570776;193.31616662591742;180.02648654364876;172.75059806516649;10.356595330298335;8.031689032672437;9.962960874858316;8.377681362010922;16.776562566315047;5.597145833080159;serB;phosphoserine phosphatase SerB;COG3830;ACT domain, binds amino acids and other small ligands;ACT;HELO_RS03855;T;serB; phosphoserine phosphatase SerB;3.1.3.3;serB;phosphoserine phosphatase SerB;0.12848318261239378;0.10099344039173719;0.05918285418326441;0.3806137442676425;0.2521305616552487
HELO_1723;276.2266121441225;294.1622032764405;162.31791518160813;162.6114888224904;129.59792304792205;165.50890576261244;11.684802594068108;14.134874865218446;3.3900015367765537;6.629285177780683;7.231666931651076;5.723933902312175;HELO_1723;ion channel domain protein;;;;;;;;;HELO_1723;ion channel domain protein;-0.09044223577895139;-0.027916285982101385;-0.3504673888984904;0.7354664122676215;0.8259086480465729
HELO_1724;216.55031018933292;90.348995996361;88.73292470463495;91.24290296466631;91.06296177948379;90.0207485408546;5.957072924928291;5.068094878914262;5.563081580306551;3.6029093856230596;8.088567719566136;7.239856286181336;prtS;protease PrtS;COG3227;Zn-dependent metalloprotease (Neutral protease B);LasB;HELO_RS03865;O;prtS; protease PrtS;;prtS;protease PrtS;1.251888296315519;-0.020558016522469025;0.016425405733917486;1.2570817179418503;0.005193421626331407
HELO_1725;191.32372092966168;71.2730099691087;42.7500764106156;33.5015972349134;39.9097513676811;37.72143389602698;9.938982070352811;3.1710991326235605;5.113001753144082;6.851260769548807;2.450385427726247;10.786029045441833;HELO_1725;uncharacterized protein;;;;;;;;;HELO_1725;uncharacterized protein;1.4120078286900881;0.17615315851160585;0.07931239101798315;2.3123324303209163;0.9003246016308282
HELO_1726;137.30501287823992;99.36272057962093;237.76706385219333;212.88488722652934;322.13163976964074;263.0035978922538;5.605232849290163;2.568138991900933;24.67815645194152;7.500202583738048;47.67493725058747;21.024756546498526;leuA;2-isopropylmalate synthase;COG0119;Isopropylmalate/homocitrate/citramalate synthases;LeuA;HELO_RS03875;E;leuA; 2-isopropylmalate synthase;2.3.3.13;leuA;2-isopropylmalate synthase;0.4626299638489648;-0.14495374981247977;0.2915644294552564;-0.9327041429916969;-1.3953341068406617
HELO_1727;40.98032576928559;43.43560793528571;37.877011202003835;42.22837065312972;38.73965576126438;35.23562712372467;2.331189473597916;1.0153174101389848;1.8736862841121755;0.8472763221948401;2.158728234865128;0.8025770735974902;epmB;lysine 2%2C3-aminomutase;COG1509;L-lysine 2,3-aminomutase (EF-P beta-lysylation pathway);EpmB;HELO_RS03880;E;epmB; lysine 2,3-aminomutase;5.4.3.-;epmB;lysine 2%2C3-aminomutase;-0.08200286414342717;0.1015084482724955;0.13317051250291811;0.21230449904230042;0.2943073631857276
HELO_1728;144.5702272278638;144.80437120085153;138.22609343433635;152.03743890588154;139.50206813672523;125.79342567073219;8.496730156638579;11.925792024334125;4.446745552690114;0.16822515646292668;9.68055988069891;6.990389281945315;epmA;elongation factor P--(R)-beta-lysine ligase;COG2269;Elongation factor P--beta-lysine ligase (EF-P beta-lysylation pathway);EpmA;HELO_RS03890;J;epmA; elongation factor P--(R)-beta-lysine ligase;6.3.1.-;epmA;elongation factor P--(R)-beta-lysine ligase;-0.0023186538786559296;0.13494968046207756;0.14811142386891074;0.19923537563839488;0.20155402951705081
HELO_1729;104.13986954809086;66.69769444110297;114.11079232941115;98.68947216497236;116.20238412315359;114.41206404383969;8.920660056121442;1.963530187084036;7.8312116698539205;4.432679813420175;4.762384028355045;3.4037910538720184;psd;phosphatidylserine decarboxylase;COG0688;Phosphatidylserine decarboxylase;Psd;HELO_RS03895;I;psd; phosphatidylserine decarboxylase;4.1.1.65;psd;phosphatidylserine decarboxylase;0.6351312436625793;-0.0037709358860276154;0.022207880227611554;-0.13448418703330312;-0.7696154306958825
HELO_1730;154.9457712382924;112.19603989816619;160.43586850679358;164.41387409190824;168.55558895539983;165.76308456934814;7.9700916813643214;5.78989673807516;9.417964096344596;5.069964501207009;2.982794741875363;8.858830451222568;rhdA;thiosulfate sulfurtransferase RhdA;COG2897;3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains;SseA;HELO_RS03900;P;rhdA; thiosulfate sulfurtransferase RhdA;2.8.1.1,2.8.1.2;rhdA;thiosulfate sulfurtransferase RhdA;0.46222094471194985;-0.046838804284201174;0.023958377180656854;-0.09675553076164345;-0.5589764754735933
HELO_1731;130.07363525406453;59.62093404411522;84.37362789876404;78.14875236821801;77.7286137609011;85.31761150140893;5.096659614226055;2.3615832235592027;5.061539011216477;2.8749247045071695;6.4827323826348255;7.029040481277701;rsgA;ribosome biogenesis GTPase RsgA;COG1162;Ribosome biogenesis GTPase RsgA;RsgA;HELO_RS03905;J;rsgA; ribosome biogenesis GTPase RsgA;3.6.1.-,3.1.3.100;rsgA;ribosome biogenesis GTPase RsgA;1.1124895381376607;-0.015864457502482665;-0.13276686876086252;0.602650674901791;-0.5098388632358697
HELO_1732;67.08673661883167;68.96401312905427;119.77295222486022;128.0080887238258;139.3236066357077;125.33522863296939;4.602529659536327;8.314502373021128;8.102933440276104;5.106828882551252;14.995925947563435;9.448694851741532;orn;oligoribonuclease;COG1949;Oligoribonuclease (3'-5' exoribonuclease);Orn;HELO_RS03910;A;orn; oligoribonuclease;3.1.-.-;orn;oligoribonuclease;-0.03923925766683389;-0.06495960011030721;0.15150074255400892;-0.8918112994328444;-0.8525720417660105
HELO_1733;721.6445897804801;25.284640003573895;257.1094130266406;228.3804450482628;166.61712376566697;192.41473211443156;89.2197875258642;1.9815869448290009;13.127924089207843;12.516950959572132;55.248890856783056;35.4226182771963;HELO_1733;DUF541 family protein;COG2968;Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain;YggE;HELO_RS03915;S;;orn;;HELO_1733;DUF541 family protein;4.78099439611325;0.41628506927926523;-0.2065281446558478;1.9015885900600455;-2.879405806053205
HELO_1734;76.75211197555375;48.31932079210119;78.2511199759454;107.93277000363598;69.669117016484;76.20905253668376;3.0187728475725972;1.5278409636567358;3.0009223764497164;3.9507629523259316;2.5012860937497545;2.3441672324005225;HELO_1734;uncharacterized protein;COG0628;Predicted PurR-regulated permease PerM;PerM;HELO_RS03920;R;;;;HELO_1734;uncharacterized protein;0.6567289320051453;0.03766131434155273;-0.12769012601086516;0.01011185440209772;-0.6466170776030475
HELO_1735;894.6622932325873;935.398813906107;821.4276634653221;577.9442454565007;810.1620144159347;804.2645899777514;49.408664195129475;189.1901680459897;42.07424224587061;3.493512859080967;55.905891004406875;79.51300289441454;trxA;thioredoxin;COG3118;Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family;CnoX;HELO_RS03925;O;trxA; thioredoxin;;trxA;thioredoxin;-0.06416823606338085;0.03042589740326207;0.010527199588475256;0.1534919760503044;0.21766021211368525
HELO_1736;171.00016535102918;207.8722731468845;266.42673215938845;289.04552305037254;341.3978506854814;257.775324556432;7.144551010871936;3.2571304229532276;19.308850828997475;3.5823771968744778;49.610005302351816;31.478582145115183;cysB;LysR family transcription regulator CysB;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS03930;K;cysB; LysR family transcription regulator CysB;;cysB;LysR family transcription regulator CysB;-0.2802110419971342;0.04744362928903456;0.4039735894847638;-0.5892901042835792;-0.309079062286445
HELO_1737;858.6364747020122;851.6251666829447;665.8324048835376;467.66299890273814;523.6285879345481;690.9681860945067;77.93944153067285;42.583004643018995;100.41938630800983;10.545103343428218;80.95062803449221;73.75628008374164;HELO_1737;homolog to phosphoadenosine phosphosulfate reductase;COG0175;Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme;CysH;HELO_RS03935;EH;;cysB;1.8.4.8,1.8.4.10;HELO_1737;homolog to phosphoadenosine phosphosulfate reductase;0.011815058632860698;-0.05338149594359187;-0.39940928535390974;0.3130209880735393;0.3012059294406786
HELO_1738;76.09850739031636;49.13195903714121;53.27656533105762;60.28913158157479;49.90076883678709;53.781002917732074;2.323883173682776;2.2655098524815944;3.6437281306815903;10.913451165676786;2.764785470433508;1.2501717904842362;pabB;aminodeoxychorismate synthase component 1;COG0147;Anthranilate/para-aminobenzoate synthases component I;TrpE;HELO_RS03940;EH;pabB; aminodeoxychorismate synthase component 1;2.6.1.85;pabB;aminodeoxychorismate synthase component 1;0.6209723178647266;-0.013346250176775598;-0.10598823098058485;0.493027251353678;-0.12794506651104864
HELO_1739;97.69299628647677;99.68463297511802;89.94852200059118;81.25607055024899;171.27008704658172;84.90439768137276;5.6061296596271575;6.182987983051607;9.136280294817304;4.746766715691306;8.951178034405723;8.011933945823952;HELO_1739;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS03945;K;;pabB;;HELO_1739;GntR family transcription regulator;-0.028823895261904653;0.0823182041455146;1.003868320070855;0.20021571920733194;0.2290396144692366
HELO_1740;107.66145993045738;112.48059375479704;114.14659519256377;96.29239708340776;325.71585180692114;126.56358007027215;3.5621755967450173;3.8075566973155723;9.195163783568544;5.826550364932145;6.815168292760515;5.735517521126583;prpB;2-methylisocitrate lyase;COG2513;2-Methylisocitrate lyase and related enzymes, PEP mutase family;PrpB;HELO_RS03950;G;prpB; 2-methylisocitrate lyase;4.1.3.30;prpB;2-methylisocitrate lyase;-0.06260526852814774;-0.14774474025053674;1.3568199615779797;-0.23137615678290402;-0.16877088825475628
HELO_1741;136.9714751300102;168.6809734862083;279.70172377919073;211.2554232380371;758.8845073793705;281.15584694173896;4.54139438709835;10.143954024293276;7.70623721934326;9.86947139221998;23.272927690200255;22.469386761077534;prpC;methylcitrate synthase;COG0372;Citrate synthase;GltA;HELO_RS03955;C;prpC; methylcitrate synthase;2.3.3.5;prpC;methylcitrate synthase;-0.2984547746796906;-0.007454322556304405;1.429287918251692;-1.032122217680696;-0.7336674430010053
HELO_1742;136.9181579228788;164.6685403999441;285.99076368452944;206.02780964129215;825.1580318585784;305.6603988529928;5.795925680461391;6.837310977369123;14.696149258797144;19.31098522188894;12.80215910190799;21.368392629466914;prpD;2-methylcitrate dehydratase;COG2079;2-methylcitrate dehydratase PrpD;PrpD;HELO_RS03960;G;prpD; 2-methylcitrate dehydratase;4.2.1.79;prpD;2-methylcitrate dehydratase;-0.2644872576400319;-0.0956375666590965;1.4297759007547537;-1.152829462999713;-0.888342205359681
HELO_1743;9.797185752196762;9.427878559568148;11.722254477679131;12.092077397930337;6.392461359501414;11.371027196694262;0.12219668623801963;0.7782527940395217;1.387588953021282;1.440675800506924;0.2572351251237159;1.5341654462916239;HELO_1743;BCC family transport protein;COG1292;Choline-glycine betaine transporter;BetT;HELO_RS03990;M;;;;HELO_1743;BCC family transport protein;0.05020964126676786;0.04038905372755508;-0.7428385933004633;-0.19630996770155829;-0.24651960896832614
HELO_1744;63.3702583141745;81.02149640467023;72.37712542699221;74.54971993495532;60.94089041000729;72.06546163980425;1.8306707056889984;3.39626079674662;2.8461002991490774;3.2014664668760813;0.7227231023721881;0.6345419859435012;rlmM;23S rRNA (cytidine(2498)-2'-O)-methyltransferase RlmM;COG2933;23S rRNA C2498 (ribose-2'-O)-methylase RlmM;RlmM;HELO_RS03995;J;rlmM; 23S rRNA (cytidine(2498)-2'-O)-methyltransferase RlmM;2.1.1.186;rlmM;23S rRNA (cytidine(2498)-2'-O)-methyltransferase RlmM;-0.3496078062003898;0.006140788524219509;-0.23829747698786186;-0.18279534080468274;0.16681246539570704
HELO_1745;122.48267230200388;59.331802024289914;122.53454885125558;89.15488610791051;99.22014461953535;110.0409042186978;4.507317756321468;10.270599141673852;16.12442934333577;8.824454676205221;5.327177287242846;4.364390087191971;HELO_1745;ABM domain protein;COG1359;Quinol monooxygenase YgiN;YgiN;HELO_RS04000;C;;rlmM;;HELO_1745;ABM domain protein;1.0333180305747662;0.15382335500228983;-0.14791869638881394;0.15321738881827418;-0.880100641756492
HELO_1746;268.60321291197124;288.6309579127704;307.6394675807194;381.673484630906;308.5314147608655;338.61800381538995;28.40079530973965;39.12900208365942;20.35943956993473;21.474700776669717;7.144743971578051;62.404389408966786;tusA;sulfurtransferase TusA;COG0425;Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis);TusA;HELO_RS04005;JOH;tusA; sulfurtransferase TusA;2.8.1.-;tusA;sulfurtransferase TusA;-0.1033781271591554;-0.13799038123013396;-0.13382710307098478;-0.333075251518105;-0.22969712435894962
HELO_1747;187.7011431650113;36.24126366992186;113.08338956582905;97.14597235724362;109.87227713794931;116.884653024854;1.9562025428371337;1.6410159120313652;18.0163767169936;14.704937924667277;22.823622658329544;7.4502847851088525;HELO_1747;uncharacterized protein;;;;;;;;;HELO_1747;uncharacterized protein;2.341129230571137;-0.04728715943426742;-0.08847723684373232;0.67872725160362;-1.6624019789675168
HELO_1748;47.67695478270982;22.993358779989247;26.323985235472104;34.25321650338955;19.0983434385049;22.21160646316102;2.8046619253793437;1.672170533979838;2.9558297654274086;2.750635319493238;2.580790645947852;4.736146739431236;HELO_1748;DUF3080 family protein;;;;;;;;;HELO_1748;DUF3080 family protein;1.0206037846357034;0.23532154343951106;-0.2077697789508095;1.0683925419501392;0.04778875731443577
HELO_1749;89.71576063230059;52.34248795016179;73.71204206876727;107.75128730123372;57.57052450447021;72.76745742733597;4.697970880392853;2.3451913562997504;5.906347815529231;2.2986337684160723;5.132759851447159;10.717821850684237;HELO_1749;MATE family transport protein;COG0534;Na+-driven multidrug efflux pump, DinF/NorM/MATE family;NorM;HELO_RS04020;V;;;;HELO_1749;MATE family transport protein;0.7660681059306311;0.018356284431019887;-0.3328096965881384;0.29836871065308035;-0.4676993952775508
HELO_1750;99.92224791176199;84.75920049159008;110.43966595554217;133.92758724007413;112.96774063380985;109.88917613100718;5.559883676234702;5.8813773883911145;11.36307836886067;3.1919622290715055;7.512301048153603;2.1838273125985066;epmC;elongation factor P hydroxylase;COG3101;Elongation factor P hydroxylase EpmC (EF-P beta-lysylation pathway);EpmC;HELO_RS04025;J;epmC; elongation factor P hydroxylase;1.14.-.-;epmC;elongation factor P hydroxylase;0.23488088480040936;0.0071442873127525175;0.03950696603682147;-0.1358743052749274;-0.37075519007533675
HELO_1751;78.30369971814197;80.56971813273661;85.46935235204221;72.62169718946092;98.89183150629968;79.27915391202998;4.183569034837518;5.1047450180331495;5.48207144053172;0.5646565763159924;9.004697556852477;9.126988819822644;HELO_1751;uncharacterized protein;;;;;;;;;HELO_1751;uncharacterized protein;-0.040645493933502586;0.10716347192929554;0.31534129702573477;-0.017637238879611772;0.023008255053890814
HELO_1752;138.94050249262466;161.84180858334125;134.06409988454524;126.4420386584299;122.23340958884808;136.59940387342678;9.044698442049166;3.997391001841336;1.6882297264242965;7.556702025279308;4.152696435955937;4.425241202534838;tatD;3'-5' ssDNA/RNA exonuclease TatD;COG0084;3'->5' ssDNA/RNA exonuclease TatD;TatD;HELO_RS04035;N;tatD; 3'-5' ssDNA/RNA exonuclease TatD;3.1.21.-;tatD;3'-5' ssDNA/RNA exonuclease TatD;-0.21865757265698882;-0.026829963370951226;-0.15908078428827466;0.024339357328070577;0.2429969299850594
HELO_1753;226.2765134088376;194.98666211729338;262.8045322595205;240.81254981370046;224.60712421998178;266.9323084478636;6.213373892290384;2.8040266272316163;21.267931590780734;11.973963582139252;20.57392589687934;10.76096925447723;HELO_1753;ABC-type transport system ATP-binding protein;COG0488;ATPase components of ABC transporters with duplicated ATPase domains;Uup;HELO_RS04040;R;;tatD;;HELO_1753;ABC-type transport system ATP-binding protein;0.213693129798755;-0.022399207301262436;-0.24805593226990208;-0.23741995334618693;-0.4511130831449419
HELO_1754;308.0689496919841;103.79840818100382;389.6153919174745;398.8378125652785;390.6922371928406;370.8493775678948;24.048289987450794;7.139927368432837;26.637368366650723;12.246917075477738;36.959510633560164;16.426117138106243;HELO_1754;UspA domain protein;COG0589;Nucleotide-binding universal stress protein,  UspA family;UspA;HELO_RS04045;T;;;;HELO_1754;UspA domain protein;1.560311919086467;0.07103044145508974;0.07500217907330686;-0.2667896347080223;-1.8271015537944892
HELO_1755;158.9294512398928;153.8598550788855;157.20713381635633;185.33375573759375;151.19348660322123;147.78688002325808;3.818259943050993;12.226968350158382;8.1092218681195;8.258163017252336;5.047941202466174;4.034677746201915;HELO_1755;uncharacterized protein;;;;;;;;;HELO_1755;uncharacterized protein;0.04647244050113297;0.08856733904365299;0.03265930171315823;0.10418832196907246;0.05771588146793949
HELO_1756;222.18314392208336;194.90093030180495;252.1379091941616;188.9374592345077;210.44073010433803;248.4560504889023;3.044776349878768;14.902124257983777;33.96647700070598;19.614879912397885;14.154717556025803;11.102489627360319;HELO_1756;MarR family transcription regulator;COG1846;DNA-binding transcriptional regulator, MarR family;MarR;HELO_RS04055;K;;;;HELO_1756;MarR family transcription regulator;0.18810382188643704;0.021137915476950653;-0.23853235022469033;-0.16055759131455005;-0.3486614132009871
HELO_1757;47.27834621164461;32.288591340271104;35.19429103943188;40.464179434992644;38.319012757793985;36.289444037885765;1.3650227008060893;2.4688458247216833;3.3470194641830164;3.210779700540038;1.4649999415881028;1.7990985585904404;HELO_1757;DUF2914 domain protein;;;;;;;;;HELO_1757;DUF2914 domain protein;0.5363484351813312;-0.043005130030437044;0.07645981059851525;0.372608969416258;-0.16373946576507326
HELO_1758;110.40212964896318;58.54764566360988;132.842717958259;131.9657133462991;141.91862978626523;122.71831208491601;6.728426493545697;2.5978076158134797;7.575219731999306;4.729800211119717;11.052979932869691;10.255368033940721;fadB;fatty acid oxidation complex alpha subunit;COG1250;3-hydroxyacyl-CoA dehydrogenase;FadB;HELO_RS04065;I;fadB; fatty acid oxidation complex alpha subunit;1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8;fadB;fatty acid oxidation complex alpha subunit;0.9036604381432509;0.11347959206679992;0.2081349317707879;-0.15128224306888693;-1.0549426812121379
HELO_1759;154.88157976707353;63.34981051348233;112.11194602426538;107.63549178047532;153.2093582512871;111.38461543816557;1.8274669888333097;4.2735263727000214;6.027524124070008;6.586033022544008;5.7258318160175605;11.048455913414188;fadA;fatty acid oxidation complex beta subunit;COG0183;Acetyl-CoA acetyltransferase;PaaJ;HELO_RS04070;I;fadA; fatty acid oxidation complex beta subunit;2.3.1.16;fadA;fatty acid oxidation complex beta subunit;1.2764426521908812;0.009306748287078115;0.4564457628104899;0.4720059019745113;-0.8044367502163698
HELO_1760;48.16695715429876;14.853922334592847;26.805251587479315;23.65084110384653;24.80993117522232;23.866708921353148;1.862149397263789;0.9228535802894395;2.7804329190202197;4.676897176224696;2.729330415039426;2.873877164530125;HELO_1760;flavodoxin family protein;COG0655;Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase;WrbA;HELO_RS04075;C;;fadA;;HELO_1760;flavodoxin family protein;1.632849258348661;0.16114180973803016;0.053710713088561235;0.9834734911225596;-0.6493757672261014
HELO_1761;173.16946947839645;158.5324587539079;243.32455435587795;290.56593960378797;264.56452227629205;254.6378640238423;2.764673073353101;10.236812745135722;9.120556395736378;7.292327235209745;16.079960683919587;9.984413858321336;HELO_1761;UPF0098 family protein;COG1881;Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family;PEBP;HELO_RS04080;R;;;;HELO_1761;UPF0098 family protein;0.12664176602312338;-0.06530267794145761;0.0549608865781952;-0.5536097849957766;-0.6802515510189
HELO_1762;229.62454850583381;183.60050372943587;143.16975872942297;188.21504884560522;167.75483437566513;158.4613848947051;8.964847639891554;13.388581645560487;5.856798791124787;7.2428615363763775;3.5914840438264886;4.262675922273131;HELO_1762;peptidase domain protein;COG4067;Uncharacterized conserved protein;;HELO_RS04085;S;;;;HELO_1762;peptidase domain protein;0.32113959705917505;-0.14543852944865776;0.08172172828940383;0.5323389829796623;0.21119938592048726
HELO_1763;231.80075227868448;123.83739070225435;134.14365713085317;135.0224760202591;144.1066925220207;113.93458744546591;9.61863146339186;7.372313361874857;8.47999506042157;10.4645136074154;12.98996224721358;20.916105092030218;HELO_1763;DUF393 domain protein;COG3011;Predicted thiol-disulfide oxidoreductase YuxK, DCC family;YuxK;HELO_RS04090;R;;;;HELO_1763;DUF393 domain protein;0.8990456121275212;0.23368078581914364;0.3363010442352996;1.0182827044166078;0.11923709228908663
HELO_1764;135.0170825050614;82.38385237982955;78.69028405418409;84.85493692063808;76.84019396373566;79.02288673225713;3.5321129252580725;3.817232750187783;3.394549636943482;2.542243126182226;1.192290464778866;6.853006133734252;HELO_1764;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS04095;K;;;;HELO_1764;LysR family transcription regulator;0.7059479200910506;-0.006008833530073865;-0.03989736810275257;0.765303273918974;0.05935535382792345
HELO_1765;2.7978849986509573;1.7735363396708095;2.324970834848147;2.4661643079208773;2.6918605056460687;1.8618677656309577;0.5525256276711547;0.28605151415721075;0.5043330994823675;0.29341120823434536;0.3326346847307043;0.2838578837582331;HELO_1765;aldo/keto reductase domain protein;COG0667;Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family;PdxI;HELO_RS04100;HR;;;;HELO_1765;aldo/keto reductase domain protein;0.4534695926220047;0.21638467300745656;0.36739102980706817;0.40823920782597756;-0.045230384796027145
HELO_1766;2.074173401642433;1.719574157682534;1.4906507424656892;2.0726077405041985;1.4204672813004573;1.464064749525097;0.5500609965154819;0.37452564080920203;0.09520604502135961;0.5383162003404232;0.018760876863902317;0.44933360708780995;HELO_1766;major facilitator superfamily transport protein;COG2807;Cyanate permease;CynX;HELO_RS04105;P;;;;HELO_1766;major facilitator superfamily transport protein;0.17681777796931453;0.015482563367450242;-0.025754574306468436;0.31915837690756255;0.14234059893824802
HELO_1767;27.615705402590226;23.366352443030234;40.752015132421626;51.40138732107069;33.656091550055756;35.23391865168033;0.9676841953868359;0.754238420687267;7.938525528149831;15.712509107869707;4.170032835038184;0.1919287104291844;soxR;MerR family transcription regulator SoxR;COG0789;DNA-binding transcriptional regulator, MerR family;SoxR;HELO_RS04110;K;soxR; MerR family transcription regulator SoxR;;soxR;MerR family transcription regulator SoxR;0.23191687017306606;0.20450499011421552;-0.06423188064894703;-0.34053366879998137;-0.5724505389730474
HELO_1768;233.82731267590904;229.1156448583333;249.0207842428091;186.6790736804703;299.845918008311;273.45291228460746;16.249688749204395;4.655064953842948;8.542138863700254;2.146512383742487;21.063000828852545;15.015429333341931;HELO_1768;ChrR family protein;COG0431;NAD(P)H-dependent FMN reductase;SsuE;HELO_RS04115;C;;soxR;;HELO_1768;ChrR family protein;0.029241146205265522;-0.13451061697318867;0.13246613369509141;-0.22495843064963061;-0.25419957685489614
HELO_1769;53.183408619933516;152.96121262437683;63.25801855705706;39.29977228460035;31.699924163229145;72.64430283180562;0.8119914736220446;5.344271122601632;16.894275395325735;5.225440327519532;2.7017632272716408;4.86930856947658;HELO_1769;SAF family transport protein;COG1115;Na+/alanine symporter;AlsT;HELO_RS04120;E;;;;HELO_1769;SAF family transport protein;-1.5066438793145736;-0.19669742686971503;-1.1712866319411246;-0.4427227670219853;1.0639211122925882
HELO_1770;53.35056249361039;35.056138876108946;79.20678028735334;86.70925556998854;96.75984946686587;82.14550205507064;6.923404591741914;2.983027066760402;8.493494587926346;5.303603803342024;5.017223393133608;8.758719527586326;HELO_1770;cytosine deaminase;COG0590;tRNA(Arg) A34 adenosine deaminase TadA;TadA;HELO_RS04125;J;;;3.5.4.1,3.5.4.21;HELO_1770;cytosine deaminase;0.5920500543498957;-0.05191401956608832;0.23360384390345423;-0.6133432534537837;-1.2053933078036794
HELO_1771;63.78120591009057;48.60022837506542;26.321139167721537;23.54406583058775;29.317552478347512;27.79696972505343;1.8334790644322017;0.7146248443664636;3.677552406989494;2.1974897752932945;4.41783230911017;4.050668133002431;HELO_1771;YqjZ family protein;COG2329;Heme-degrading monooxygenase HmoA and related ABM domain proteins;HmoA;HELO_RS04130;H;;;;HELO_1771;YqjZ family protein;0.3852285610785682;-0.07589936763830529;0.07423628375528679;1.1696583179608213;0.7844297568822531
HELO_1772;179.82824460730527;227.20976299689912;221.28258604439546;148.97624719219652;131.32827391046717;240.7892624562518;29.252064797233217;10.57042437102367;35.75561570567032;13.194784211185851;20.312416450570186;19.067245891155867;phnA;PhnA family protein;COG2824;Uncharacterized Zn-ribbon-containing protein;PhnA;HELO_RS04135;R;phnA; PhnA family protein;;phnA;PhnA family protein;-0.33574047437936105;-0.1213552479468234;-0.8696288299389598;-0.4191301395969287;-0.08338966521756763
HELO_1773;170.41454265564755;110.85642842551981;45.37006297577582;45.440147962918296;44.51445777978074;48.05698913085576;6.404729512486606;9.112401848983417;0.7406555835823553;1.051778148177563;1.8133570074661112;2.40578126553639;HELO_1773;uncharacterized protein;COG0702;Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains;YbjT;HELO_RS04155;R;;;;HELO_1773;uncharacterized protein;0.6158413406572052;-0.08126500525293956;-0.10813379755803432;1.8049589151706584;1.1891175745134532
HELO_1774;282.9625588349515;190.86903089126994;220.32339548850177;214.0446030611124;212.61412875223706;235.04313647135965;16.727420997660527;7.100385295394258;18.647635692358403;18.189108642342145;15.173813736698873;22.128628463123672;HELO_1774;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG2130;NADPH-dependent curcumin reductase CurA;CurA;HELO_RS04160;QR;;;;HELO_1774;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);0.5655788509003363;-0.09289457115070388;-0.14404346153210756;0.2666501856810646;-0.29892866521927175
HELO_1775;449.43616295415404;333.11244478524196;68.69594481158951;84.27418334655304;31.128116864410014;76.48565002011058;61.379536825316386;18.72552571709467;8.230290642310232;5.61554753135845;0.3345506075828577;6.629745986106365;HELO_1775;GntR family transcription regulator;COG2186;DNA-binding transcriptional regulator, FadR family;FadR;HELO_RS04165;K;;;;HELO_1775;GntR family transcription regulator;0.43098893767274404;-0.1528544379752237;-1.2700927326102054;2.5393215979717407;2.1083326602989967
HELO_1776;1009.8987077827301;1941.7690629437968;375.64168013892225;405.5438758945786;221.3826355671738;402.6761143016133;36.730106502770774;32.327729207269435;18.850342332966825;17.444446457154687;19.501081457526013;49.83446609994831;HELO_1776;TRAP transporter substrate-binding protein;COG4663;TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component;FcbT1;HELO_RS04170;Q;;;;HELO_1776;TRAP transporter substrate-binding protein;-0.9424759716813469;-0.10000556328774657;-0.8601540827630085;1.324368316663783;2.26684428834513
HELO_1777;172.08143002948304;234.08695042608517;61.39830101064692;72.95457347198739;39.960227312796434;73.53212970493418;18.72481980041014;5.376807491368252;4.821429253400772;2.0902765449349223;1.6165272100625228;1.8031082113799908;HELO_1777;TRAP transporter small transmembrane protein;COG4665;TRAP-type mannitol/chloroaromatic compound transport system, small permease component;FcbT2;HELO_RS04175;Q;;;;HELO_1777;TRAP transporter small transmembrane protein;-0.44174351211802954;-0.25635573655108956;-0.8636387625406243;1.2155165563331396;1.6572600684511691
HELO_1778;62.383851182308696;128.88917247402634;21.64400944619125;21.870063377031602;10.61787428343919;21.192353034138097;9.266129510812943;7.230281830953697;0.26403720962621147;0.6399584960798158;0.8860077491721664;0.5722401003901039;HELO_1778;TRAP transporter large transmembrane protein;COG4664;TRAP-type mannitol/chloroaromatic compound transport system, large permease component;FcbT3;HELO_RS04180;Q;;;;HELO_1778;TRAP transporter large transmembrane protein;-1.0350939479528716;0.02906678737649049;-0.9337165195222066;1.51405267683612;2.5491466247889916
HELO_1779;474.7956739277729;984.8512967848893;186.01263667569947;197.09830128120095;101.11106348646376;186.3763097720928;27.7234662239108;25.283977558917186;9.924341322887782;7.563786724476279;0.6513744100539755;6.526813543100487;dgoD;D-galactonate dehydratase;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS04185;MR;dgoD; D-galactonate dehydratase;4.2.1.6;dgoD;D-galactonate dehydratase;-1.051027896269341;-0.0028028046376427085;-0.8757993755381852;1.3444035916843466;2.3954314879536875
HELO_1780;741.4152262865496;1402.4663149962162;166.64222231967622;172.00496447687604;90.13798583450114;175.7957000608894;50.40662680891288;103.63832679856642;5.921493519290101;15.509988709266338;2.4407866819561748;7.00038691508774;dgoA;2-dehydro-3-deoxy-6-phosphogalactonate aldolase;COG0800;2-keto-3-deoxy-6-phosphogluconate aldolase;Eda;HELO_RS04190;G;dgoA; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase;4.1.2.21;dgoA;2-dehydro-3-deoxy-6-phosphogalactonate aldolase;-0.9186962334278874;-0.07669763508691751;-0.9559587944160368;2.070143112553316;2.9888393459812033
HELO_1781;433.77228164052644;855.3592266245769;112.41909485719297;130.7852617823379;63.09838150302891;112.30173878483356;28.685815532706492;38.99212092168024;7.75882531462282;4.542941666107894;2.9317543169152196;6.604906581089699;dgoK;2-dehydro-3-deoxygalactonokinase;COG3734;2-keto-3-deoxy-galactonokinase;DgoK;HELO_RS04195;G;dgoK; 2-dehydro-3-deoxygalactonokinase;2.7.1.58;dgoK;2-dehydro-3-deoxygalactonokinase;-0.977956140997648;0.0014935463672447469;-0.821810167566114;1.9400899644470107;2.9180461054446587
HELO_1782;133.5463161840281;313.17681173456674;124.7537952635035;97.39256950181995;77.10268307667177;121.71927714548951;13.774812683151774;14.630350806071972;10.951751587338055;4.349066356334861;6.290705874440678;9.429811671245973;gntK;gluconokinase;COG3265;Gluconate kinase;GntK;HELO_RS04200;G;gntK; gluconokinase;2.7.1.12;gntK;gluconokinase;-1.2234738132111502;0.03524005132599761;-0.6519178745436509;0.13274100113706222;1.3562148143482124
HELO_1783;185.38687200233736;247.3750595568971;171.17135642830905;198.021860541608;127.09807503385849;130.64829806684358;3.4955905857613927;13.238063369905026;3.967862941190709;44.119868915229574;22.128777457784032;17.190354329460206;HELO_1783;IscR family transcription regulator;COG1959;DNA-binding transcriptional regulator, IscR family;IscR;HELO_RS04205;K;;gntK;;HELO_1783;IscR family transcription regulator;-0.41422006481650886;0.387156275839013;-0.039440074464352826;0.5016113780779214;0.9158314428944303
HELO_1784;177.10440505261977;258.487128277098;248.9766165701021;282.5361999789321;237.95346815775534;234.55843281036837;7.006202564121795;10.323358664798029;31.631217109494894;7.043448383327846;15.015500717342995;36.317284755535205;sufB;iron-sulfur cluster assembly complex subunit SufB;COG0719;Fe-S cluster assembly scaffold protein SufB;SufB;HELO_RS04210;O;sufB; iron-sulfur cluster assembly complex subunit SufB;;sufB;iron-sulfur cluster assembly complex subunit SufB;-0.5429397771993703;0.08570816764179146;0.02064472663336936;-0.40336178127317535;0.1395779959261949
HELO_1785;218.4032064721292;357.81610643921584;287.5522876670341;266.62759211140474;239.41438956644924;258.1325546848637;8.102582592816843;19.12586486477489;25.055990518738806;12.687200274813847;7.440801740392204;26.196860810014464;sufC;iron-sulfur cluster assembly complex subunit SufC;COG0396;Fe-S cluster assembly ATPase SufC;SufC;HELO_RS04215;O;sufC; iron-sulfur cluster assembly complex subunit SufC;;sufC;iron-sulfur cluster assembly complex subunit SufC;-0.7096600408230049;0.1551424969496331;-0.10816702338998407;-0.2401056617256625;0.46955437909734243
HELO_1786;245.2463813858548;370.290102546627;283.82930989483776;275.47181944647264;251.92593239124986;288.43744080159246;1.8496309224509673;12.725320228598205;11.871776792327774;13.531444306514636;8.535154716034159;3.735053871855096;sufD;iron-sulfur cluster assembly complex subunit sufD;COG0719;Fe-S cluster assembly scaffold protein SufB;SufB;HELO_RS04220;O;sufD; iron-sulfur cluster assembly complex subunit sufD;;sufD;iron-sulfur cluster assembly complex subunit sufD;-0.5924443337049459;-0.023153944736083787;-0.1945365933451244;-0.23314903267267528;0.3592953010322706
HELO_1787;209.87577917626405;372.60400796646064;248.85893937916202;286.24496833419124;218.12136834131775;259.03759499442197;5.411805990816884;22.42455868741725;16.638040669253865;24.14518993285883;17.22125708920169;9.21853108877196;sufS;cysteine desulfurase SufS;COG0520;Selenocysteine lyase/Cysteine desulfurase;CsdA;HELO_RS04225;E;sufS; cysteine desulfurase SufS;2.8.1.7,4.4.1.16;sufS;cysteine desulfurase SufS;-0.8251165329273515;-0.05760638098311244;-0.24699003595336055;-0.3023268170821236;0.5227897158452279
HELO_1788;179.28956320518134;245.75620991223437;172.2665716281156;183.30029656331507;149.25293968473252;184.732452037995;6.487102876360814;14.627055221719877;8.712171316069886;9.058238198198898;5.024556343788904;2.1924445012226843;HELO_1788;SufT domain protein;COG2151;Metal-sulfur cluster biosynthetic enzyme;PaaD;HELO_RS04230;O;;sufS;;HELO_1788;SufT domain protein;-0.45277050935180085;-0.10023256993060503;-0.30583269427993276;-0.04291002877035943;0.4098604805814414
HELO_1789;117.41420576583319;201.84449341249183;92.82012282716981;99.72838934658034;70.1529709893739;91.32511119525348;9.077990746990734;12.38503159548209;4.647847416261378;4.644887234722353;2.715798995770911;3.1175295360463267;sanA;SanA family protein;COG2949;Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin;SanA;HELO_RS04235;M;sanA; SanA family protein;;sanA;SanA family protein;-0.7765319716954613;0.023174294582157806;-0.37579909731501626;0.35904716665618075;1.135579138351642
HELO_1790;301.9250755417981;224.68964117039096;341.1435177838617;348.16097921291697;377.6699014326735;323.948017024119;30.737209682422602;22.532153961853023;15.492695614502818;21.699024529710993;31.267226307979303;24.57156246788237;HELO_1790;uncharacterized protein;;;;;;;;;HELO_1790;uncharacterized protein;0.42462080410960557;0.07439267042796516;0.22073180915214508;-0.1012479375156925;-0.5258687416252981
HELO_1791;131.7639544145425;120.1275016923006;122.05016208371997;101.25305488723609;156.84235519128478;129.98558169463118;6.229309013671741;1.1803634399422414;8.885055815424069;5.662994074483332;10.085312083388795;10.825378158266671;rimK;ribosomal protein S6--L-glutamate ligase;COG0189;Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily;LysX;HELO_RS04245;JEHQ;rimK; ribosomal protein S6--L-glutamate ligase;6.3.2.-;rimK;ribosomal protein S6--L-glutamate ligase;0.13233704380029376;-0.090161456963469;0.26907637291782205;0.01945549117432055;-0.11288155262597321
HELO_1792;205.1983540248015;224.0107680306396;124.31636381783763;90.5559655437325;131.10037942771433;141.61683753549087;6.696873800313071;4.963317502196877;2.7585308677681484;2.496915148361379;8.637965384109838;8.324052372009893;HELO_1792;peptidase domain protein;COG4067;Uncharacterized conserved protein;;HELO_RS04250;S;;rimK;;HELO_1792;peptidase domain protein;-0.12596122770438534;-0.18656950419207696;-0.1105097079546038;0.531888498108616;0.6578497258130014
HELO_1793;325.7810616299896;287.27436281746424;315.3075368162965;246.81848486650776;284.35057082416205;324.1679970696752;19.697743274855124;10.747717998968614;13.510886513294428;5.778307831340661;5.313327093340269;7.200822402664591;HELO_1793;DUF3549 family protein;;;;;;;;;HELO_1793;DUF3549 family protein;0.18088183656865553;-0.039857342741095536;-0.18844982578572456;0.007139100699767198;-0.17374273586888833
HELO_1794;137.79705279254844;313.73920128021297;298.5611530934901;247.9791943509471;286.6506546526232;301.9419679436376;16.392560266898197;15.926601022034589;41.915856736207196;10.792422226095463;60.762470773037776;39.84536169269334;HELO_1794;ABC-type transport system periplasmic substrate-binding protein;COG0834;ABC-type amino acid transport/signal transduction system, periplasmic component/domain;HisJ;HELO_RS04260;TE;;;;HELO_1794;ABC-type transport system periplasmic substrate-binding protein;-1.181179945694823;-0.016190907036827795;-0.07472370155770847;-1.126064521005353;0.05511542468947006
HELO_1795;97.05119214026361;237.00111274076502;100.98306931536312;91.35595848266877;81.45982058409447;108.71340108771813;9.635277769672733;24.422092963383136;11.461660386691749;13.22764656721721;8.247802141795646;10.364199580014162;HELO_1795;ABC-type transport system permease protein;COG0765;ABC-type amino acid transport system, permease component;HisM;HELO_RS04265;E;;;;HELO_1795;ABC-type transport system permease protein;-1.2793612422456118;-0.10541009284010272;-0.4119765290589381;-0.16213267996675995;1.1172285622788518
HELO_1796;90.93316393271475;259.8263137004528;118.01518752960449;101.0204160662323;91.30123433003307;137.29315402292517;9.5127307527885;13.178924016936861;10.814020577546753;5.189553805116542;10.681628598901261;19.446963450141276;HELO_1796;ABC-type transport system ATP-binding protein;COG1126;ABC-type polar amino acid transport system, ATPase component;GlnQ;HELO_RS04270;E;;;;HELO_1796;ABC-type transport system ATP-binding protein;-1.5044321267642635;-0.21658405237717115;-0.5833078939418721;-0.5890724422391029;0.9153596845251606
HELO_1797;118.05081799987316;233.27912955691644;94.29777494259316;78.26736450589198;76.88898495741378;92.45450686512326;3.8593701293544065;8.609102913122799;4.080715881147375;7.042518723997968;3.810766555173718;6.3091131960989015;HELO_1797;DUF446 domain protein;COG3098;Uncharacterized conserved protein YqcC, DUF446 family;YqcC;HELO_RS04275;S;;;;HELO_1797;DUF446 domain protein;-0.9766509059454949;0.028178289855222083;-0.26284492284205907;0.34924138835910945;1.3258922943046043
HELO_1798;174.26989190968638;275.5727969071308;89.05891239633478;69.43614414933334;80.83577455319204;96.96685796401187;10.84817884515072;18.844082563064358;7.899731896654253;4.657720248239093;2.34803339364573;10.852938547960768;HELO_1798;GGCT domain protein;;;;;;;;;HELO_1798;GGCT domain protein;-0.6580810738028555;-0.12142471530862409;-0.2595621142953668;0.8392125139638882;1.4972935877667437
HELO_1799;4312.810629222041;71.32787620244643;316.2891259403254;290.938212541141;143.32145973587276;273.7938252102934;230.13625548684234;2.7389417326223606;23.294565964452687;20.542325034669425;31.860400903995114;27.43723578118491;HELO_1799;OmpW family outer membrane protein;COG3047;Outer membrane protein OmpW;OmpW;HELO_RS04285;M;;;;HELO_1799;OmpW family outer membrane protein;5.898267245444778;0.20744849213414618;-0.929063750373853;3.9725413540485306;-1.9257258913962474
HELO_1800;15.937999467700541;4.357462646525923;12.472024134363833;18.535583574414748;17.977144307054747;14.066949661227923;2.42669481908052;0.3938034061324839;2.871860164924067;0.3048272457063356;3.2383301771409;1.942989064270409;HELO_1800;uncharacterized protein;;;;;;;;;HELO_1800;uncharacterized protein;1.6606416980381926;-0.16142074152785746;0.3328755414562323;0.16887611972966;-1.4917655783085326
HELO_1801;274.0256196020421;96.55661062023238;203.3381373315137;628.210300316767;805.1781717158025;216.82480545266503;14.56279058174468;3.2271905501504965;13.705869769748777;67.36939613082356;33.63018235977155;26.92959128139154;putP;SSS family transport protein (probable substrate proline);COG0591;Na+/proline symporter;PutP;HELO_RS04295;E;putP; SSS family transport protein (probable substrate proline);;putP;SSS family transport protein (probable substrate proline);1.4952544760047068;-0.0922097632179204;1.887930466309327;0.33639776237292995;-1.158856713631777
HELO_1802;125.42633563438515;14.763887336372711;34.22189791322714;248.90936740742507;246.32659131962598;38.12636463186388;7.945445674671071;0.2977047285956139;0.8530245027737342;33.700003736466606;6.25748000511452;4.054595388636001;putA;bifunctional proline dehydrogenase / pyrroline-5-carboxylate dehydrogenase;COG4230;Delta 1-pyrroline-5-carboxylate dehydrogenase;PutA2;HELO_RS04305;E;putA; bifunctional proline dehydrogenase / pyrroline-5-carboxylate dehydrogenase;1.5.5.2,1.2.1.88;putA;bifunctional proline dehydrogenase / pyrroline-5-carboxylate dehydrogenase;3.0036017710592993;-0.15166842047753093;2.6602043837225073;1.6920840442274052;-1.311517726831894
HELO_1803;69.6887114289073;69.2723742899741;43.36773005334562;46.28966145648257;67.93782590151979;43.25647457037318;1.310740353855392;2.40364407582403;1.2403618079603023;1.0671328030635239;2.3765392342324714;3.2701699314865675;HELO_1803;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS04310;K;;putA;;HELO_1803;AraC family transcription regulator;0.008522199856931145;0.0036222117547719535;0.639407269047898;0.6755913115532364;0.6670691116963052
HELO_1804;125.91237586976781;175.15195916895024;109.61068869626497;114.96660285311815;86.9232225409293;98.69293811350644;6.581657628870148;13.116383699460012;5.694455230430315;10.873773274892406;4.946748864050118;11.089088535204823;HELO_1804;uncharacterized protein;;;;;;;;;HELO_1804;uncharacterized protein;-0.4729877600794792;0.14992758689131236;-0.18124704838398564;0.3482695424865687;0.8212573025660479
HELO_1805;48.593831787206305;8.769864667135893;56.636377610483784;77.15063290628932;100.60200818766019;50.808239727038675;3.8482410734801342;0.896832635682498;4.026564695028888;5.267114962151926;20.981480143784797;5.080015289106227;HELO_1805;CBS domain protein;COG3448;CBS-domain-containing membrane protein;;HELO_RS04325;T;;;;HELO_1805;CBS domain protein;2.3437502140270645;0.15379809999500527;0.9716754460813588;-0.06302086924882655;-2.406771083275891
HELO_1806;194.32879960739547;122.76830030430524;86.82279303876508;72.32922523094992;62.491683166459744;95.7475138411334;3.879556668180009;3.2973882272999795;2.8002982971968984;7.6170367602666635;2.690922209544405;6.4505740772700095;HELO_1806;YigM family protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS04335;GER;;;;HELO_1806;YigM family protein;0.6582628213355015;-0.13962917083563386;-0.6076569639116229;1.0136081849509608;0.3553453636154593
HELO_1807;179.9921285154072;134.08224144210755;155.54036807213558;191.60430576626467;163.3179501529371;167.35831661726192;9.30269414175143;7.234161115698251;5.791073812570778;11.372669457220542;17.036188307034532;14.121472555492028;nadK;inorganic polyphosphate/ATP-NAD kinase;COG0061;NAD kinase;NadK;HELO_RS04340;H;nadK; inorganic polyphosphate/ATP-NAD kinase;2.7.1.23;nadK;inorganic polyphosphate/ATP-NAD kinase;0.42208893123858626;-0.10500024744017722;-0.03504490020042805;0.10439196514325833;-0.31769696609532794
HELO_1808;121.88012134297215;91.23778003160204;62.70010265530757;74.03433765270609;60.15657886962904;60.878958191316485;3.162081483466689;2.789304287223621;1.3823533747782526;1.424922222150063;2.9402793682589405;5.496339283727519;HELO_1808;uncharacterized protein;;;;;;;;;HELO_1808;uncharacterized protein;0.4138218499202635;0.04184679000658065;-0.016941203582773845;0.9897307332690168;0.5759088833487533
HELO_1809;43.26868159226728;51.06201999045246;38.49727943555515;37.72328282132343;36.28130271039222;36.93839974903215;1.0140312106962315;2.5817961866171686;1.522012988041569;3.7018805986537817;1.9425981668140384;3.3055877609458975;HELO_1809;peptidase S54 family protein;COG0705;Membrane-associated serine protease, rhomboid family;GlpG;HELO_RS04350;O;;;;HELO_1809;peptidase S54 family protein;-0.23394488115263012;0.0580944573721478;-0.025206554231256284;0.22262758099813684;0.45657246215076697
HELO_1810;149.3163795709115;117.46442195149699;94.05940346490179;86.99016192387616;97.65887846550534;102.83437193072056;9.145723956889602;2.972274047314071;4.315405492806912;1.8815090426587533;0.22942781761811262;10.90011174924222;HELO_1810;DUF2797 domain protein;;;;;;;;;HELO_1810;DUF2797 domain protein;0.3435483803178876;-0.12738283977202336;-0.07376330080704285;0.5337181313366894;0.19016975101880185
HELO_1811;198.43587093452467;153.2683578399095;237.17482022923082;217.46149868872865;185.16470380244678;194.5052911084861;9.358353291579999;8.47283112576464;21.354867391295052;35.72142703238655;28.84991210442972;13.443371415210121;dcmA;putative dichloromethane dehalogenase;COG0625;Glutathione S-transferase;GstA;HELO_RS04365;O;dcmA; putative dichloromethane dehalogenase;2.5.1.18;dcmA;putative dichloromethane dehalogenase;0.3704827396746193;0.2848132471605549;-0.07062808408654586;0.028717266274646214;-0.3417654733999731
HELO_1812;213.16596051556215;75.59622220214412;133.79199210159015;149.31227304665836;117.84466138537829;121.1851089115708;3.1315767687144422;2.710964653384075;8.823123011544114;1.7638698588790682;17.018155705978554;10.407403027640482;HELO_1812;uncharacterized protein;;;;;;;;;HELO_1812;uncharacterized protein;1.4833840527795763;0.14166631952782005;-0.039991372520017165;0.8096607266884011;-0.6737233260911752
HELO_1813;5.273787646720703;4.880804297519835;8.40177854742852;6.741798398983882;6.604161531324411;8.500683982261998;0.8998245062753829;0.25295273050305733;0.8763157106330118;0.8332147276812606;0.8238032329642745;1.1124624290384642;HELO_1813;radical SAM domain protein;COG1533;DNA repair photolyase;SplB;HELO_RS04375;L;;;;HELO_1813;radical SAM domain protein;0.09332321707019453;-0.015097681833397214;-0.3212422023069119;-0.5986946829540605;-0.692017900024255
HELO_1814;93.81895358809481;9.552574456792627;34.75425967654885;50.243591397213414;27.248853257931785;25.682971549833187;2.2586500375022;0.40709900265945353;2.481541190405078;3.322166783176727;7.531043678634847;4.156207703757652;opgD;glucan biosynthesis protein OpgD;COG3131;Periplasmic glucan biosynthesis protein OpgG;MdoG;HELO_RS04380;M;opgD; glucan biosynthesis protein OpgD;;opgD;glucan biosynthesis protein OpgD;3.16758046303218;0.42219579010871655;0.08227296229849568;1.8292561304819905;-1.3383243325501897
HELO_1815;131.23393761747232;72.25171294439737;88.07971192536225;101.35953499052964;84.35751186103202;77.248551135143;3.354648274545222;2.203115084478571;3.1761631126728385;5.344749890586951;7.262592533865219;5.47681675204012;cobT;nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase;COG2038;NaMN:DMB phosphoribosyltransferase;CobT;HELO_RS04385;H;cobT; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase;2.4.2.21;cobT;nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase;0.8521580880795421;0.18703285352523125;0.12545408368371636;0.7569565454280749;-0.09520154265146719
HELO_1816;69.34502188163063;62.76854051212664;48.54223196282678;59.337095554598314;47.559883337880414;47.90418278502647;0.8096577682690705;1.3851127093238398;1.987340554225044;3.3863740119531016;5.813796618849645;2.0863365971149768;cbiB;adenosylcobinamide-phosphate synthase;COG1270;Cobalamin biosynthesis protein CobD/CbiB;CbiB;HELO_RS04390;H;cbiB; adenosylcobinamide-phosphate synthase;6.3.1.10;cbiB;adenosylcobinamide-phosphate synthase;0.1416034694009234;0.018701001478636847;-0.010192908852613591;0.5244904671591843;0.38288699775826096
HELO_1817;57.35991191417011;49.9250299105816;43.67672018822923;48.76964891296689;43.28093945381389;40.71763990944584;0.5772270699663601;2.8581917933770518;1.7632985379707116;3.5854230354992627;2.6129316492711183;1.3076617749970905;cobD;threonine-phosphate decarboxylase;;;;;;;;;cobD;threonine-phosphate decarboxylase;0.19660278316665458;0.098865735807383;0.0860282876856786;0.4843201630871592;0.2877173799205046
HELO_1818;111.80823474277555;77.11669097504677;37.46418985248139;42.985888665628465;34.570170789764184;30.60217034015069;5.109862909030631;4.51760343752622;5.624545500668041;4.0217032387849825;5.669280894174711;1.9264449158300274;cobU;adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase;COG2087;Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase;CobU;HELO_RS04400;H;cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase;2.7.1.156,2.7.7.62;cobU;adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase;0.530169641980331;0.2834922803923332;0.17064425982380982;1.8357768382257493;1.3056071962454183
HELO_1819;88.77113988772193;58.418097935524514;38.59885253014889;45.55532335069629;36.41005175412797;37.317898410120314;1.9608846187743263;3.19135075914836;3.6755040173362286;2.420084001127794;3.387973921654596;0.6384681789477566;cobS;adenosylcobinamide-GDP ribazoletransferase;COG0368;Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase);CobS;HELO_RS04405;H;cobS; adenosylcobinamide-GDP ribazoletransferase;2.7.8.26;cobS;adenosylcobinamide-GDP ribazoletransferase;0.5953492910571487;0.04744018848007592;-0.03459247519443043;1.2282332771381395;0.6328839860809907
HELO_1820;127.20356406991168;79.34744055190704;51.85337973460624;51.86320486272598;48.048969501569495;48.57717623211625;9.172346781313584;3.716129109943757;2.2224643942007343;2.0352277627055035;3.3671065281530645;2.7361093951974316;HELO_1820;homolog to phosphoglycerate mutase;COG0406;Broad specificity phosphatase PhoE;PhoE;HELO_RS04410;G;;cobS;3.1.3.73;HELO_1820;homolog to phosphoglycerate mutase;0.6741123965113403;0.09231962621690659;-0.015453275823417378;1.3706883622814257;0.6965759657700854
HELO_1821;114.85141949396456;59.15075837829708;83.88107862091267;100.99665497501701;102.01513416683929;84.95774743803089;4.0771098501387995;1.7115931119199108;3.611805785151426;2.6902106134580768;14.59541972028528;1.5654179613760966;HELO_1821;homolog to cobalamin biosynthesis protein CobU;COG2087;Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase;CobU;HELO_RS04415;H;;;2.7.1.156,2.7.7.62;HELO_1821;homolog to cobalamin biosynthesis protein CobU;0.9456208891678397;-0.018184687454912307;0.26115672040487237;0.43057613934419425;-0.5150447498236455
HELO_1822;227.0850489587673;287.68586150796835;264.05024149247976;316.1880577314626;315.543711053261;287.90098847901754;11.664972064468662;4.796313636240651;14.508004016702614;18.430617209282445;25.93897850636413;14.859123744093033;btuB;TonB-dependent receptor BtuB (probable substrate cobalamin);COG4206;Outer membrane cobalamin receptor protein BtuB;BtuB;HELO_RS04420;H;btuB; TonB-dependent receptor BtuB (probable substrate cobalamin);;btuB;TonB-dependent receptor BtuB (probable substrate cobalamin);-0.33992857213455796;-0.1243092850343892;0.13182959292253393;-0.3410032594431529;-0.001074687308594946
HELO_1823;174.4267363950108;282.0097366848017;174.16954904338232;209.95976532866692;182.71773766266946;184.46772092589347;4.414557592396747;14.500530047890717;21.979074038760537;22.12446670045292;4.404499349339119;11.841802204520079;btuF;ABC-type transport system periplasmic substrate-binding protein (probable substrate cobalamin);COG0614;ABC-type Fe3+-hydroxamate transport system, periplasmic component;FepB;HELO_RS04425;P;btuF; ABC-type transport system periplasmic substrate-binding protein (probable substrate cobalamin);;btuF;ABC-type transport system periplasmic substrate-binding protein (probable substrate cobalamin);-0.6899830460302079;-0.08241611703931095;-0.013677196790354174;-0.0802994774812742;0.6096835685489337
HELO_1824;155.76893052160622;203.20549706748844;133.73841108358081;160.61192319003393;143.90856211868933;139.97603221410415;1.4022674102385382;1.69136504151117;4.744533823496608;12.092710313863954;9.99117244048705;9.517226785958087;btuC;ABC-type transport system permease protein (probable substrate cobalamin);COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS04430;P;btuC; ABC-type transport system permease protein (probable substrate cobalamin);;btuC;ABC-type transport system permease protein (probable substrate cobalamin);-0.3813820378997024;-0.06528871486599552;0.03969293472799684;0.15318975889230657;0.534571796792009
HELO_1825;144.6916818021401;171.64452537947216;153.05773377378637;183.30042880432902;165.50777910079364;146.67449916254316;3.1577901130044737;5.761691496334718;17.533620344312517;10.478672930598202;15.97716749614188;4.533718665592504;btuD;ABC-type transport system ATP-binding protein (probable substrate cobalamin);COG1120;ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component;FepC;HELO_RS04435;HP;btuD; ABC-type transport system ATP-binding protein (probable substrate cobalamin);7.2.2.-;btuD;ABC-type transport system ATP-binding protein (probable substrate cobalamin);-0.24488607677270569;0.06105038911912519;0.17316886127280107;-0.019502209313786878;0.2253838674589188
HELO_1826;53.43139643149064;59.78441739688896;61.445333666830834;47.2092329863025;75.37104456425541;64.66324005137832;4.028669869018213;3.362534934209776;3.365462462359675;0.7758401328215284;2.229065603623207;2.462723271179733;HELO_1826;ABC-type transport system ATP-binding protein;COG1120;ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component;FepC;HELO_RS04440;HP;;btuD;7.2.2.-;HELO_1826;ABC-type transport system ATP-binding protein;-0.1592624751856473;-0.07249217119634377;0.21793981707160182;-0.2706468905101085;-0.1113844153244612
HELO_1827;69.45310544567123;91.88332207561656;66.77817688133915;52.91030566478961;57.25166494775717;63.7047070805483;3.84435974656217;4.4962082309703835;3.1603428990901565;2.5141065902735296;4.752681706825788;5.574957980213264;HELO_1827;ABC-type transport system permease protein;COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS04445;P;;;;HELO_1827;ABC-type transport system permease protein;-0.3987562733948016;0.06695016334747184;-0.15157138249968494;0.12279263139617136;0.5215489047909729
HELO_1828;149.2469629132339;279.72303818198037;170.42150983961145;192.41472745612387;134.35880478837922;184.87195102979624;5.263973388834146;24.98716540277132;17.153199748840624;2.4014292084508893;12.6331057434582;4.141376304314954;HELO_1828;ABC-type transport system periplasmic substrate-binding protein;COG0614;ABC-type Fe3+-hydroxamate transport system, periplasmic component;FepB;HELO_RS04450;P;;;;HELO_1828;ABC-type transport system periplasmic substrate-binding protein;-0.9018116381517665;-0.11676092799462712;-0.45752034237098194;-0.30697324842618645;0.59483838972558
HELO_1829;641.0785504361834;749.7042939131312;1096.8939853047548;1075.7415257768628;1282.178641240984;1154.3950036287997;8.593730353384982;10.876843067534221;41.140760136107524;9.203147131613164;87.77384211897322;49.81014431515466;chlD;probable cobaltochelatase subunit ChlD;COG1240;vWFA (von Willebrand factor type A) domain of Mg and Co chelatases;ChlD;HELO_RS04455;H;chlD; probable cobaltochelatase subunit ChlD;6.6.1.1;chlD;probable cobaltochelatase subunit ChlD;-0.22549493082475358;-0.07364740929835811;0.15133587212729616;-0.8475644517352219;-0.6220695209104683
HELO_1830;334.3706286132876;401.8179297774678;486.2562984994326;456.8945811710678;543.6203453608733;503.0924101728899;7.898867780865342;14.988970523568428;6.915980323191388;14.620739792560068;37.2678394773191;26.52655084090344;cobB;hydrogenobyrinate a%2Cc-diamide synthase;COG1797;Cobyrinic acid a,c-diamide synthase;CobB;HELO_RS04460;H;cobB; hydrogenobyrinate a,c-diamide synthase;6.3.5.9,6.3.5.11;cobB;hydrogenobyrinate a%2Cc-diamide synthase;-0.264371555581393;-0.04900739814358879;0.11156264540229088;-0.5879318878807993;-0.3235603322994063
HELO_1831;371.8884739862836;427.58046289381485;603.5174505963058;513.8145309777078;597.3689559760658;593.1934742282416;15.610313828422752;16.51199378925656;16.343676045934927;11.037116849131346;43.242365943075;23.671715354130207;cobW;CobW family protein;COG0523;Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family;YejR;HELO_RS04465;R;cobW; CobW family protein;;cobW;CobW family protein;-0.2008218813881406;0.024851225571673297;0.010102567839032517;-0.6721885567831034;-0.4713666753949628
HELO_1832;255.29907835206004;266.7015783981589;342.2686001854701;353.66660219112964;378.48327057328225;361.215637355732;0.6742910305089534;7.741513191712602;4.531765115465223;2.6918977316096844;19.401003632382622;9.778112257147614;cobN;cobaltochelatase subunit CobN;COG1429;Cobalamin biosynthesis protein CobN, Mg-chelatase;CobN;HELO_RS04470;H;cobN; cobaltochelatase subunit CobN;6.6.1.2;cobN;cobaltochelatase subunit CobN;-0.06279735456612201;-0.0775109351330876;0.06718745539080473;-0.49902054006809315;-0.43622318550197114
HELO_1833;178.38010509610857;184.37441300662374;177.92364533423617;183.40209801720735;187.2638300119437;186.82901052748562;6.749366988077944;9.413279250317418;7.500435944389214;6.120208828279582;5.72486277740286;8.207334034686175;cobG;precorrin-3B synthase;COG0155;Sulfite reductase, beta subunit (hemoprotein);CysI;HELO_RS04475;P;cobG; precorrin-3B synthase;1.14.13.83;cobG;precorrin-3B synthase;-0.04742223337469831;-0.07007585026664565;0.0033359432873822925;-0.06640001606016188;-0.018977782685463573
HELO_1834;208.95118510900537;183.26375040336313;212.7245330525312;193.66336103181138;217.94106229171743;207.9251034038825;5.589811991850408;1.7496736723744555;1.9967713932439655;13.464134739365159;12.39567298502328;14.603444912703328;cobH;precorrin-8X methylmutase;COG2082;Precorrin-8X methylmutase CbiC/CobH;CobH;HELO_RS04480;H;cobH; precorrin-8X methylmutase;5.4.99.61,5.4.99.60;cobH;precorrin-8X methylmutase;0.18828164948938575;0.03276667195856575;0.06755670676295455;0.007068081861209663;-0.1812135676281761
HELO_1835;218.73459832027876;199.92444670058123;217.36613989093743;218.26620770448253;224.06915365263862;224.9485218298972;17.091697516149473;11.240309345186397;1.5146944620450324;3.585948785567647;3.4456664802927124;10.871958763673646;cobI;precorrin-2 C(20)-methyltransferase;COG2243;Precorrin-2 methylase;CobF;HELO_RS04485;H;cobI; precorrin-2 C(20)-methyltransferase;2.1.1.130,2.1.1.151;cobI;precorrin-2 C(20)-methyltransferase;0.12910893819547908;-0.04924495121432049;-0.005625773822253599;-0.04023207157967423;-0.16934100977515332
HELO_1836;263.32431088603283;224.38630521141712;403.98363209099193;422.3636387281542;449.33948465716867;416.64140985250793;4.290112245322105;6.290005315411559;19.06759593565345;13.600257566839986;23.023370229500454;9.51396279036106;cobJ;precorrin-3B C17-methyltransferase;COG1010;Precorrin-3B methylase;CobJ;HELO_RS04490;H;cobJ; precorrin-3B C17-methyltransferase;2.1.1.131;cobJ;precorrin-3B C17-methyltransferase;0.22990926309360482;-0.04440116376422054;0.10874821051978323;-0.6599556435653966;-0.8898649066590014
HELO_1837;41.21105807011881;19.95323596622761;31.164935935628478;41.13713628734461;33.99249814687423;33.75793890971024;3.426165671473711;2.3160828791115238;1.0619884422901336;2.9385200037765484;1.0977021144597543;2.544184424364548;cobK;cobalt-precorrin-6A reductase;COG2099;Precorrin-6x reductase;CobK;HELO_RS04495;H;cobK; cobalt-precorrin-6A reductase;1.3.1.54,1.3.1.106;cobK;cobalt-precorrin-6A reductase;1.0104479252021852;-0.11185371997005422;0.00970312841459986;0.2802784574312982;-0.730169467770887
HELO_1838;210.97022712652551;174.82546701095376;315.51299231696095;321.6318280198606;310.3821238911055;294.8847615391218;12.926913227103853;6.48479762690385;8.386827096201207;4.078252304813568;16.901748667286057;23.278536359036654;cobL;precorrin-6Y C(5%2C15)-methyltransferase (decarboxylating);COG2242;Precorrin-6B methylase 2;CobL;HELO_RS04500;H;cobL; precorrin-6Y C(5,15)-methyltransferase (decarboxylating);2.1.1.132,2.1.1.289,2.1.1.196;cobL;precorrin-6Y C(5%2C15)-methyltransferase (decarboxylating);0.269717591974195;0.09722932331161616;0.07365072552059537;-0.4811737564862346;-0.7508913484604296
HELO_1839;178.44200507186636;143.23083240249062;88.04752282982845;86.17169105453803;88.75941005205175;90.42652824767966;7.829196824566117;7.330357588259034;6.279494729257571;15.940172133661214;7.463416401125399;13.906984397602429;HELO_1839;CbiG domain protein;;;;;;;;;HELO_1839;CbiG domain protein;0.31513804195444717;-0.03803735900997918;-0.026549643459448546;0.9728329038270882;0.657694861872641
HELO_1840;140.87350063076747;116.55675462182951;167.49620967566057;180.8164505319801;177.60645552304467;173.88458607952978;4.461206979842105;1.6955723874527675;2.1150813693748645;14.25124579863852;4.519927523794901;7.569665245745039;cobM;precorrin-4 C(11)-methyltransferase;COG2875;Precorrin-4 methylase;CobM;HELO_RS04510;H;cobM; precorrin-4 C(11)-methyltransferase;2.1.1.133,2.1.1.271;cobM;precorrin-4 C(11)-methyltransferase;0.27124770926715325;-0.0536870007498127;0.03038108686036267;-0.3017979935053212;-0.5730457027724745
HELO_1841;170.95389957121537;149.60187424580067;160.50505273956824;189.63354760461448;181.78747635800815;169.0991135419736;3.174828279873055;5.306205051887133;2.625172979303631;5.925240839676342;4.5233900493964745;2.0752129927250347;cobF;precorrin-6A synthase (deacetylating);COG2243;Precorrin-2 methylase;CobF;HELO_RS04515;H;cobF; precorrin-6A synthase (deacetylating);2.1.1.152;cobF;precorrin-6A synthase (deacetylating);0.19128210916574062;-0.0747963217082992;0.10379160533219611;0.01564621114932674;-0.17563589801641388
HELO_1842;93.78621494933236;121.5360637940499;118.39148385480114;121.92039723152703;126.21800777070224;124.93969086686542;1.6047099719045488;6.66443389188627;6.785082117427134;3.4484582542776026;4.359959851932989;6.031809985780818;cobO1;cob(I)yrinic acid a%2Cc-diamide adenosyltransferase;COG2109;ATP:corrinoid adenosyltransferase;BtuR;HELO_RS04520;H;cobO1; cob(I)yrinic acid a,c-diamide adenosyltransferase;2.5.1.17;cobO1;cob(I)yrinic acid a%2Cc-diamide adenosyltransferase;-0.3704572497989185;-0.0770330977792879;0.014569868048721624;-0.4099838672947014;-0.0395266174957829
HELO_1843;115.39385043291388;110.16045104918693;135.04274787747897;130.0870994562017;148.4878858770857;142.02373576972832;0.6290786394410272;4.31127282631097;5.735741112537246;12.322855708873462;7.084817553472588;3.7742319084357248;bluB;5%2C6-dimethylbenzimidazole synthase;COG0778;Nitroreductase;NfnB;HELO_RS04525;C;bluB; 5,6-dimethylbenzimidazole synthase;1.13.11.79;bluB;5%2C6-dimethylbenzimidazole synthase;0.06637124313022547;-0.0721945400884767;0.0637739847684724;-0.297239755276677;-0.3636109984069025
HELO_1844;144.36667454249744;104.66723602457382;154.1404300514924;140.12971166340233;164.08241615532586;149.44320223289301;9.20322320264814;1.2979712135531167;8.880974167958076;0.4550447557796591;6.379039001221364;9.927897327338977;cobQ;cobyric acid synthase;COG1492;Cobyric acid synthase;CobQ;HELO_RS04530;H;cobQ; cobyric acid synthase;6.3.5.10;cobQ;cobyric acid synthase;0.4601684546450553;0.044355785880063614;0.13396753892139213;-0.04952235219247836;-0.5096908068375336
HELO_1845;172.20404740022323;101.54625235036139;160.29104447504648;167.77138546969158;184.19368798937055;175.8827442557084;6.921781177925799;2.6301770527021535;13.26103196448926;7.133172522389158;11.0558548009854;4.421505076862761;HELO_1845;uncharacterized protein;;;;;;;;;HELO_1845;uncharacterized protein;0.7561978749616731;-0.13312697669197782;0.066241614438181;-0.03032067011083317;-0.7865185450725063
HELO_1846;14.94027462293115;16.8292521037193;23.938926860717118;26.630220757580815;37.102283958984565;25.748081515982808;2.136392090071687;1.1899525539001943;2.62915699679419;2.1993361583848596;8.879381115177093;2.9106224368802702;ugpQ;glycerophosphoryl diester phosphodiesterase;COG0584;Glycerophosphoryl diester phosphodiesterase;UgpQ;HELO_RS04540;I;ugpQ; glycerophosphoryl diester phosphodiesterase;3.1.4.46;ugpQ;glycerophosphoryl diester phosphodiesterase;-0.16156970183645303;-0.10103603277912399;0.5104420604275681;-0.7467589344724397;-0.5851892326359867
HELO_1847;4.210889225150349;1.7765805595529356;4.708038420524401;5.390969168455371;11.444302082254206;4.098251437978202;0.11802623857809182;0.2142087196740358;0.3969576511564029;0.5510392099548266;2.668714290088383;0.7826900922181688;upgC;ABC-type transport system ATP-binding protein (probable substrate sn-glycerol-3-phosphate);COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS04545;G;upgC; ABC-type transport system ATP-binding protein (probable substrate sn-glycerol-3-phosphate);7.6.2.10;upgC;ABC-type transport system ATP-binding protein (probable substrate sn-glycerol-3-phosphate);0.9082203309851373;0.16299251892356104;1.2874108897191632;0.03152705916340093;-0.8766932718217364
HELO_1848;3.185326556014337;1.1198352605212198;1.7233416678421503;2.022078255911007;3.836131833476287;1.8472589456742021;0.6607198966784931;0.1668505297310223;0.20390227468887306;0.2147521956526895;0.8232487985367289;0.4482764688944305;ugpE;ABC-type transport system permease protein (probable substrate sn-glycerol-3-phosphate);COG0395;ABC-type glycerol-3-phosphate transport system, permease component;UgpE;HELO_RS04550;G;ugpE; ABC-type transport system permease protein (probable substrate sn-glycerol-3-phosphate);;ugpE;ABC-type transport system permease protein (probable substrate sn-glycerol-3-phosphate);0.981388039543688;-0.06419571293624227;0.7642798673322628;0.5557664862243781;-0.42562155331930995
HELO_1849;4.2096146481107235;1.0392366504018447;2.7801663021637815;3.1854226757496362;6.408069720459943;3.5079516382602343;0.5088273114820029;0.30704134554902296;0.7073507202331695;0.642981497769129;1.2003096703529355;0.47762481919680644;ugpA;ABC-type transport system permease protein (probable substrate sn-glycerol-3-phosphate);COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS04555;G;ugpA; ABC-type transport system permease protein (probable substrate sn-glycerol-3-phosphate);;ugpA;ABC-type transport system permease protein (probable substrate sn-glycerol-3-phosphate);1.353147453515003;-0.25402233339718094;0.7166256382501914;0.20870462299216674;-1.1444428305228362
HELO_1850;11.212608241712994;3.3575663230376604;18.640967758562983;26.642783306468203;45.544044983188236;18.684900935449345;1.6454856908024396;0.4491415735224241;2.5378108688788825;0.8086476664277737;6.853572885593768;1.4314283382946025;ugpB;ABC-type transport system periplasmic substrate-binding protein (probable substrate sn-glycerol-3-phosphate);COG1653;ABC-type glycerol-3-phosphate transport system, periplasmic component;UgpB;HELO_RS04560;G;ugpB; ABC-type transport system periplasmic substrate-binding protein (probable substrate sn-glycerol-3-phosphate);;ugpB;ABC-type transport system periplasmic substrate-binding protein (probable substrate sn-glycerol-3-phosphate);1.4867768212778723;-0.0032234356110718565;1.2415071437343075;-0.6887181031135596;-2.175494924391432
HELO_1851;316.44988510644475;321.76681251151126;307.92656883033743;246.57882167462594;195.3682688451032;260.0868546572993;1.597389097602385;2.802827483494895;27.5041224381305;46.219124283865476;22.954958106308204;12.067594762774899;HELO_1851;uncharacterized protein;;;;;;;;;HELO_1851;uncharacterized protein;-0.023963389859526174;0.24273413153790813;-0.4109679985384096;0.2819990338882903;0.30596242374781646
HELO_1852;501.99410773695087;210.971683930411;469.17026195788776;424.8773445305717;642.0377669945698;505.1899430707679;17.474136276071185;13.577509918985083;26.24600550970979;31.323243905499048;47.50984509084214;31.23339567078546;azu;azurin;COG3241;Azurin;BlueCu;HELO_RS04570;C;azu; azurin;;azu;azurin;1.2466699434702457;-0.10649555230641994;0.34522462821401234;-0.009137344563137972;-1.2558072880333837
HELO_1853;206.6887765521977;175.51130793490498;264.6859742792669;252.46354370314054;270.44337080945525;254.45259908950922;5.161925041187607;6.65114729191362;12.577366641421506;8.724032841667036;18.809508640164626;14.221130519868538;qorA;quinone oxidoreductase;COG0604;NADPH:quinone reductase or related Zn-dependent oxidoreductase;Qor;HELO_RS04575;CR;qorA; quinone oxidoreductase;1.6.5.5;qorA;quinone oxidoreductase;0.2346626448487772;0.05666645466886866;0.08759563635646739;-0.2986323590178612;-0.5332950038666384
HELO_1854;55.71384669778973;40.344744655532466;51.549386830176104;58.334943160101055;56.60642118516722;51.42294572379547;3.675343344392607;1.3725124424917428;4.465103514685126;3.2478396529654794;3.3549535537296196;5.288736337357966;HELO_1854;RpiR family transcription regulator;COG1737;DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains;RpiR;HELO_RS04580;K;;qorA;;HELO_1854;RpiR family transcription regulator;0.45599705287992;0.0034755071345387023;0.1360312096350036;0.11350258933797974;-0.34249446354194024
HELO_1855;8.595192347907947;4.881053886659892;5.758433805380048;4.977766319413541;6.060682537134874;6.171511919664404;0.9508619506414947;0.4050028108737052;0.6412375741718636;0.6882071121582448;0.5473956339799788;1.4148433451431484;HELO_1855;pyridoxal phosphate-dependent aminotransferase;COG0161;Adenosylmethionine-8-amino-7-oxononanoate aminotransferase;BioA;HELO_RS04585;H;;;;HELO_1855;pyridoxal phosphate-dependent aminotransferase;0.7062370177560169;-0.0855883481685904;-0.022469652615404456;0.4200344230876518;-0.28620259466836506
HELO_1856;13.603160927882302;8.483209950630021;6.034547069177446;5.501890418978401;7.538685400453346;6.220693673522457;0.7764871265030358;0.12197697620979397;1.411348958877693;0.10692888705400858;1.7577139973373175;0.3646510206366433;HELO_1856;AhpD domain protein;;;;;;;;;HELO_1856;AhpD domain protein;0.6228332999939727;-0.037679903611216314;0.24187653261166986;1.0160713366346075;0.3932380366406347
HELO_1857;45.2593889435337;17.622113418864256;29.119673501694184;39.68408595197163;25.768261467609133;28.899505852557173;1.832631686612206;0.8050954177437578;1.1393210942920697;3.4081572755397684;0.857283611236939;2.3481023491260347;HELO_1857;CitM family transport protein;COG0471;Di- and tricarboxylate antiporter;CitT;HELO_RS04595;G;;;;HELO_1857;CitM family transport protein;1.3127293957584225;0.010584489949272857;-0.159598198735166;0.6296245677549823;-0.6831048280034402
HELO_1858;26.78840408904875;16.48788822158648;69.52910129774727;84.30577612743787;84.46759986963396;65.95721923454083;2.8267647393628916;0.6176478059150109;0.8166948856816324;4.745849343044964;8.381923547844183;7.076301748061393;fadE;acyl-CoA dehydrogenase;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS04600;I;fadE; acyl-CoA dehydrogenase;1.3.99.-;fadE;acyl-CoA dehydrogenase;0.6681268969632033;0.07497904327607063;0.3521379953815531;-1.2687566315624679;-1.9368835285256711
HELO_1859;60.12849029776132;146.97200504012667;108.32340007475302;105.8083828289354;146.52954540871892;116.85975667719917;5.1883240486061455;7.984929584429516;8.61832700888966;7.320028584967409;5.009887402851416;10.601046339983425;betA;choline dehydrogenase BetA;COG2303;Choline dehydrogenase or related flavoprotein;BetA;HELO_RS04605;IR;betA; choline dehydrogenase BetA;1.1.99.1;betA;choline dehydrogenase BetA;-1.27540741473244;-0.10846895781357357;0.32393271584064465;-0.9471543507102274;0.32825306402221255
HELO_1860;53.48826156291321;141.85225602195027;124.37848808271633;113.65408564762659;154.6027761967892;129.1655940765602;5.899698763480423;11.986853536379108;6.441003458080538;3.967979287648435;1.0911005588303817;5.067406101503445;betB;betaine aldehyde dehydrogenase BetB;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS04610;I;betB; betaine aldehyde dehydrogenase BetB;1.2.1.8;betB;betaine aldehyde dehydrogenase BetB;-1.3905064526307367;-0.05405832182036541;0.2575196408846194;-1.2563307917394653;0.13417566089127142
HELO_1861;45.079836548371794;63.68057565394133;66.72760971951236;61.09847777151047;64.10873285483778;71.87821586048902;3.159083592567115;1.685889462190846;4.016461383478327;3.5849960565577303;1.0754729469111657;0.3356599835270502;betI;TetR family transcription regulator BetI;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS04615;K;betI; TetR family transcription regulator BetI;;betI;TetR family transcription regulator BetI;-0.4891969194354875;-0.1057435605385848;-0.16263657972079848;-0.6613520414503107;-0.1721551220148232
HELO_1862;234.1895866338385;479.83129052375233;561.5611255020832;466.3176368664961;863.9776872184024;562.54906659698;17.921452161005227;28.500566704183502;23.67864295279531;26.663064396056303;23.85988687043255;62.8445517244251;HELO_1862;ABC-type transport system periplasmic substrate-binding protein;COG2113;ABC-type proline/glycine betaine transport system, periplasmic component;ProX;HELO_RS04620;E;;betI;;HELO_1862;ABC-type transport system periplasmic substrate-binding protein;-1.0317065996310077;-0.0025313652144607346;0.6181216905975404;-1.260717043039902;-0.2290104434088942
HELO_1863;22.783194049377844;1.4186673991978533;49.16404035429722;84.84638286555942;138.4733672335943;44.89770285988157;3.28517872468809;0.2152854475750155;3.398521358151328;13.550367965285325;27.397810409686063;12.36693060135752;pcoB;copper resistance protein PcoB;COG3667;Uncharacterized conserved protein involved in copper resistance;PcoB;HELO_RS04650;P;pcoB; copper resistance protein PcoB;;pcoB;copper resistance protein PcoB;3.2976581828011735;0.12823160176253268;1.6034958074274037;-0.9484794698117405;-4.246137652612914
HELO_1864;23.35229484374258;1.4329676234750426;65.7280352290514;135.24741895575542;178.81553114252952;59.031846307354726;6.047993043717089;0.269022469165373;8.975025891888624;6.122339053525445;32.16252226388578;14.90693929703586;pcoA;copper resistance protein PcoA;COG2132;Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA);SufI;HELO_RS04655;DMP;pcoA; copper resistance protein PcoA;;pcoA;copper resistance protein PcoA;3.323268704425142;0.15256498569607846;1.582717691099849;-1.301670308012869;-4.624939012438011
HELO_1865;30.668451096277607;7.760402105718845;19.25745635755878;41.80975394130049;35.94159519514227;16.99946142408521;2.2254475874343527;0.9901387388294856;1.6767964520137764;3.8372037105584615;9.823560821742461;1.89133645836713;HELO_1865;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS04660;T;;pcoA;;HELO_1865;sensor histidine kinase;1.853977310188744;0.17049929324709723;1.037292426267813;0.8150925676892955;-1.0388847424994485
HELO_1866;161.09475615721377;24.91438015856501;115.88051150705046;230.70159022201892;274.1405229555756;126.13091006355319;22.541165489632927;0.520955409424661;4.321850152309555;10.834389550666248;75.25760847106791;16.903259332414272;HELO_1866;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS04665;KT;;;;HELO_1866;response regulator/HTH domain transcription regulator;2.6450126280540136;-0.12128044669973903;1.1138537931191301;0.35052257606738024;-2.2944900519866334
HELO_1867;189.49535539606373;34.279327717164016;247.13706101216698;452.1239125285677;551.1018838055486;244.8565771177733;31.186422556399496;1.7203363874899336;8.762068930185968;67.8327699024729;115.66553008498008;40.18118221504898;HELO_1867;cupredoxin domain protein;COG4454;Uncharacterized copper-binding protein, cupredoxin-like subfamily;;HELO_RS04670;R;;;;HELO_1867;cupredoxin domain protein;2.4328608484898515;0.013320277523380497;1.1671175732691914;-0.36806112766866406;-2.8009219761585156
HELO_1868;4.10707544423785;2.2264835324299326;3.544656984057289;3.8184927134800257;2.7913728922403984;3.1741495204924894;0.6215628436403436;0.3509223403604249;0.3150667265508427;0.5848116049875783;0.6303511004159454;0.8358736089086471;HELO_1868;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS04675;G;;;;HELO_1868;major facilitator superfamily transport protein;0.6625347092454619;0.1226891289856118;-0.13876192298688528;0.29101509180179796;-0.3715196174436639
HELO_1869;25.080765421288955;14.11525011606286;28.60347393549976;36.99529130959144;32.42604916522421;25.569717550189562;2.2152356780359233;1.4914628183542513;4.559134048951864;4.125516179907705;2.500653812965524;2.653699757983952;HELO_1869;HTH domain protein;COG1396;Transcriptional regulator, contains XRE-family HTH domain;HipB;HELO_RS04680;K;;;;HELO_1869;HTH domain protein;0.7869813587479131;0.1559835931668907;0.33118995252321604;-0.026796680747556145;-0.8137780394954692
HELO_1870;0.9893042200187989;0.678261252935212;0.8526455374139363;1.195706166338309;1.1038548059535442;0.9460814091479831;0.16035272143424684;0.25404949698862633;0.0574001704308334;0.327027708032915;0.09617042677187863;0.3391710498987354;HELO_1870;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS04690;GER;;;;HELO_1870;DMT superfamily transport protein;0.24529660541265208;-0.070985182591081;0.11246308016536954;0.03169185859795465;-0.21360474681469743
HELO_1871;9.72453904602793;3.6425217532180176;15.431536888294582;42.76486438245811;29.930302120090346;13.531852069366144;0.42586478444564513;0.442873855835387;0.7797032935861271;4.932121728074489;4.841267516251657;1.6825974392086573;HELO_1871;esterase domain protein;COG2755;Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK;TesA;HELO_RS04720;DI;;;;HELO_1871;esterase domain protein;1.2079350649887215;0.1772488412973443;1.0898023407452788;-0.43830294442712825;-1.6462380094158497
HELO_1872;184.32339970627982;94.90474566076334;186.85895142268677;216.57189689679174;220.46879044729712;187.13997297891697;4.32089554988291;2.2950558946646837;18.032163324599768;2.9756991864708824;38.38929864237737;13.177517861579451;prc;C-terminal processing peptidase;COG0793;C-terminal processing protease CtpA/Prc, contains a PDZ domain;CtpA;HELO_RS04725;O;prc; C-terminal processing peptidase;3.4.21.102;prc;C-terminal processing peptidase;0.9503709424714266;-0.0021565406427326295;0.23529700516021723;-0.02176134867995927;-0.9721322911513859
HELO_1873;148.85028473623137;180.86618207925812;302.88610066938816;175.2780608381263;238.8961968966714;315.7175822956481;5.5040912167060245;6.903927529167199;29.103890544359498;4.299920131111141;19.91852730535184;11.90511503724807;apeB;probable aminopeptidase ApeB;COG1362;Aspartyl aminopeptidase;LAP4;HELO_RS04730;E;apeB; probable aminopeptidase ApeB;3.4.11.21;apeB;probable aminopeptidase ApeB;-0.27935547437184916;-0.05966627003448366;-0.4007866729305123;-1.0796751343508815;-0.8003196599790323
HELO_1874;237.3372437845994;281.0686009458006;300.60572052350966;244.63575897404635;221.79104261031898;284.7671608744813;12.929963236871671;10.807856258418592;15.662649273822908;13.858492287795675;20.089792994218367;20.37917259814159;ychF;ribosome-binding ATPase YchF;COG0012;Ribosome-binding ATPase YchF, GTP1/OBG family;GTP1;HELO_RS04740;J;ychF; ribosome-binding ATPase YchF;;ychF;ribosome-binding ATPase YchF;-0.24304166627905577;0.07782365462118257;-0.3591489078888541;-0.2618357257107471;-0.018794059431691323
HELO_1875;199.94823069779758;393.8638691092818;284.9195228426947;249.19540864705857;236.48560620651514;270.25943378574584;18.52678282971964;4.9282720197670615;3.040827659067309;21.178548175460914;16.719169955818153;21.494018198662296;pth;peptidyl-tRNA hydrolase;COG0193;Peptidyl-tRNA hydrolase;Pth;HELO_RS04745;J;pth; peptidyl-tRNA hydrolase;3.1.1.29;pth;peptidyl-tRNA hydrolase;-0.9745314892877541;0.0759358197701765;-0.19183323646248684;-0.432849437219728;0.5416820520680261
HELO_1876;2704.014311121508;2965.259488786225;2390.332144427789;2537.9988628286096;2250.4366466586657;2278.021310125597;109.89824998503543;32.779203751569554;53.670999665331934;146.12290469466154;108.92743765259355;116.18038361064839;rplY;50S ribosomal protein L25;COG1825;Ribosomal protein L25 (general stress protein Ctc);RplY;HELO_RS04750;J;rplY; 50S ribosomal protein L25;;rplY;50S ribosomal protein L25;-0.13300858369273527;0.06940011263269596;-0.017568532523794644;0.2472218121072718;0.38023039580000706
HELO_1877;983.264146574316;1324.409390421425;912.0121262682151;962.5792666051348;892.6346674874582;917.6586076539692;63.14147606495622;8.909101284891278;55.00227483977465;32.42248076157832;75.41575691603255;58.00386483085871;prs;ribose-phosphate pyrophosphokinase;COG0462;Phosphoribosylpyrophosphate synthetase;PrsA;HELO_RS04755;F;prs; ribose-phosphate pyrophosphokinase;2.7.6.1;prs;ribose-phosphate pyrophosphokinase;-0.4293205978151331;-0.00889480445069779;-0.039843671561540006;0.09951671692052066;0.5288373147356538
HELO_1878;468.57982694228537;346.78967798947514;486.0570554452136;472.3723396007387;367.9517439280556;426.3747412010454;69.2500609403292;116.97203460436765;82.05222928426565;132.031845701857;17.176453298833582;88.81729506196798;ispE;4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;COG1947;4-diphosphocytidyl-2C-methyl-D-erythritol kinase;IspE;HELO_RS04765;I;ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;2.7.1.148;ispE;4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;0.43315531618493;0.18858914016182204;-0.212069508902605;0.1358687878542355;-0.29728652833069447
HELO_1879;184.53334080545378;97.8425947085326;136.64968028270087;117.85284390230782;131.7165346658186;140.41819258874213;5.693784765501564;2.047038409498744;6.977064426615551;11.71032317985058;10.43989265182366;10.42044904973485;lolB;lipoprotein localization system protein LolB;COG3017;Outer membrane lipoprotein LolB, involved in outer membrane biogenesis;LolB;HELO_RS04770;M;lolB; lipoprotein localization system protein LolB;;lolB;lipoprotein localization system protein LolB;0.9084736777100444;-0.03896646700551809;-0.09161960402775371;0.3917107400390609;-0.5167629376709835
HELO_1880;161.77206277701404;108.16217250304413;191.75730361224058;163.43863725428946;157.38734008976652;195.10843108344406;12.994996011333686;3.873198027866096;11.853380156682412;7.0023563996139275;6.9897771916814575;5.913205964211528;HELO_1880;TPR domain protein;COG5010;Flp pilus assembly protein TadD, contains TPR repeats;TadD;HELO_RS04775;WU;;lolB;;HELO_1880;TPR domain protein;0.5763800933409637;-0.024866035957836097;-0.3081945358144962;-0.2687984558271337;-0.8451785491680974
HELO_1881;314.7161134664213;355.6975471321869;352.8691564842814;421.0245794704312;313.6151976432097;327.43450384148696;14.256661373780258;8.293397507137607;14.650885549108047;11.76291647861085;10.059137666671127;14.255389349174127;hemA;glutamyl-tRNA reductase;COG0373;Glutamyl-tRNA reductase;HemA;HELO_RS04780;H;hemA; glutamyl-tRNA reductase;1.2.1.70;hemA;glutamyl-tRNA reductase;-0.17607340043700148;0.10761032271690674;-0.06201733554797251;-0.056977803525327886;0.1190955969116736
HELO_1882;207.13645745017325;224.0062360148481;147.92887746828646;180.91349034828673;144.9125849347753;146.3287228651117;1.9497046913390188;10.696133963181541;1.170047054788489;0.6172532432798847;3.6375975959828053;5.052530283067114;prfA;peptide chain release factor 1;COG0216;Protein chain release factor RF1;PrfA;HELO_RS04785;J;prfA; peptide chain release factor 1;;prfA;peptide chain release factor 1;-0.11243529454715162;0.015584798888616191;-0.013934401448355338;0.4984909692668147;0.6109262638139663
HELO_1883;192.68038520072344;157.76301441627373;124.39144585848918;130.3628326339623;123.05193550735343;130.0986462260042;4.093879090622037;0.2663873735079995;6.0488707312612995;7.746403330526567;5.844299342273502;6.842554091774076;prmC;peptide chain release factor glutamine methyltransferase;COG2890;Methylase of polypeptide chain release factors;HemK;HELO_RS04790;J;prmC; peptide chain release factor glutamine methyltransferase;2.1.1.297;prmC;peptide chain release factor glutamine methyltransferase;0.2868029937466101;-0.06421385625906062;-0.0797085429197617;0.5630250659283265;0.27622207218171635
HELO_1884;154.30736269023498;160.26973279857475;188.2274544901852;143.30872843158883;152.64658809797766;191.88643652339735;5.5436621460066595;1.8755377749299724;22.56603827627583;9.916275935179764;5.818874427418147;14.34707258428785;lrp;Lrp/AsnC family transcription regulator Lrp;COG1522;DNA-binding transcriptional regulator, Lrp family;Lrp;HELO_RS04795;K;lrp; Lrp/AsnC family transcription regulator Lrp;;lrp;Lrp/AsnC family transcription regulator Lrp;-0.05434947251045141;-0.02763027835116194;-0.3281359683069862;-0.3126254733574667;-0.2582760008470153
HELO_1885;132.3552445670364;99.25969429438256;191.16357027486097;158.71719501425275;159.32465780487738;190.49084520065188;3.103755323766999;13.252975309733635;5.910623072857241;7.540965255430059;7.551892049750931;3.190078556663668;HELO_1885;ThiF/MoeB family adenylyltransferase;COG0476;Molybdopterin or thiamine biosynthesis adenylyltransferase;ThiF;HELO_RS04800;H;;lrp;2.7.7.80;HELO_1885;ThiF/MoeB family adenylyltransferase;0.4115328237482645;0.00505943934948494;-0.25627909348941813;-0.5220008573845831;-0.9335336811328476
HELO_1886;35.758814891304525;33.239078388279154;77.43415665351907;71.07560444181858;56.90947898515869;78.02165467115934;0.8984079837724642;0.5110214696955994;11.193022455833184;9.444130535942262;1.9709651849294159;9.174451351173165;HELO_1886;FAD-dependent oxidoreductase (homolog to gamma-glutamylputrescine oxidoreductase);COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS04805;E;;;1.4.3.-;HELO_1886;FAD-dependent oxidoreductase (homolog to gamma-glutamylputrescine oxidoreductase);0.10244638540718487;-0.010765997174268627;-0.44844853901636306;-1.1041578011820965;-1.2066041865892814
HELO_1887;42.97275536343457;30.662721759572396;60.04981199105842;78.58436073843676;65.03587648373477;63.514034431871515;1.6908386044158676;2.586246454319436;5.245168316881027;0.6054877799480346;3.5697733164535683;4.60910652422762;spuF;ABC-type transport system ATP-binding protein (probable substrate polyamine);COG3842;ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component;PotA;HELO_RS04810;E;spuF; ABC-type transport system ATP-binding protein (probable substrate polyamine);7.6.2.11;spuF;ABC-type transport system ATP-binding protein (probable substrate polyamine);0.4738246593277413;-0.0796261873515629;0.03363699637760931;-0.5530031039912169;-1.0268277633189582
HELO_1888;36.059651753506756;24.831204875120715;48.84217296482391;49.12432090584742;54.5103091610633;57.4845669932038;1.583699570258076;0.34617576477000295;1.7467220990701842;3.6543824177873026;2.734821952936389;2.5551520287638154;spuG;ABC-type transport system permease protein (probable substrate polyamine);COG1176;ABC-type spermidine/putrescine transport system, permease component I;PotB;HELO_RS04815;E;spuG; ABC-type transport system permease protein (probable substrate polyamine);;spuG;ABC-type transport system permease protein (probable substrate polyamine);0.5207343862038334;-0.23068900731969677;-0.07530024598306806;-0.6582066495588377;-1.178941035762671
HELO_1889;29.113434172471756;24.10156793043979;36.2237674247869;24.029170271850756;38.76675506027175;39.72394547050563;1.886020728696441;0.8719303093246085;3.125101275737663;0.2615330736411889;2.5583236248475756;3.4802569291926497;spuH;ABC-type transport system permease protein (probable substrate polyamine);COG1177;ABC-type spermidine/putrescine transport system, permease component II;PotC;HELO_RS04820;E;spuH; ABC-type transport system permease protein (probable substrate polyamine);;spuH;ABC-type transport system permease protein (probable substrate polyamine);0.26262976143810146;-0.12965326301708124;-0.034314497223543405;-0.43547009711832896;-0.6980998585564304
HELO_1890;87.86263221109255;67.02478184577114;179.81658440827258;127.2858197831667;214.26235601911154;194.00183675962762;4.368185449572003;5.644462036735228;9.358874639249317;7.683874952868178;3.519782741403718;31.78404921888532;spuE1;ABC-type transport system periplasmic substrate-binding protein (probable substrate polyamine);COG0687;Spermidine/putrescine-binding periplasmic protein;PotD;HELO_RS04825;E;spuE1; ABC-type transport system periplasmic substrate-binding protein (probable substrate polyamine);;spuE1;ABC-type transport system periplasmic substrate-binding protein (probable substrate polyamine);0.3855164514444631;-0.10896070595760943;0.1426083373656608;-1.1338389317167215;-1.5193553831611846
HELO_1891;89.04230782247267;44.93094006771964;154.98123484841503;101.97729021405583;155.3136870073086;159.3078198148731;6.0130774376852205;4.587500602415758;10.022939596480901;1.969315104973118;5.731964714339489;24.08041306573488;spuB;GlnA/PuuA domain protein SpuB;COG0174;Glutamine synthetase;GlnA;HELO_RS04830;E;spuB; GlnA/PuuA domain protein SpuB;6.3.1.2;spuB;GlnA/PuuA domain protein SpuB;0.9711367226763263;-0.039472324187540764;-0.0364006939522552;-0.8321698626045482;-1.8033065852808745
HELO_1892;48.82512178361835;19.22901418297624;53.50812622411288;59.595484947388684;83.2748437169272;56.19781047063187;2.892137161182643;0.23338712210984516;1.3081808396922048;3.229326941130387;4.487720391102863;3.0953841994106503;spuE2;ABC-type transport system periplasmic substrate-binding protein (probable substrate polyamine);COG0687;Spermidine/putrescine-binding periplasmic protein;PotD;HELO_RS04835;E;spuE2; ABC-type transport system periplasmic substrate-binding protein (probable substrate polyamine);;spuE2;ABC-type transport system periplasmic substrate-binding protein (probable substrate polyamine);1.3004473163312422;-0.06948859482484426;0.5591421250476385;-0.19908659043111765;-1.4995339067623599
HELO_1893;33.126290746387554;16.821379662747873;36.976993311481365;39.161949727947615;58.23632845474961;40.774371201391055;0.649722185999641;0.8077414888510728;1.2925097579528575;2.217977507532953;5.704412225286583;2.9626368112231147;puuB;gamma-glutamylputrescine oxidoreductase;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS04840;E;puuB; gamma-glutamylputrescine oxidoreductase;1.4.3.-;puuB;gamma-glutamylputrescine oxidoreductase;0.9372745845078301;-0.13749242268765371;0.5038641106368784;-0.2917344990333932;-1.2290090835412233
HELO_1894;205.10603228222692;32.081353095683404;88.52669125007827;72.3406752340368;76.30688737040367;85.75249217491181;13.58244558125445;3.688538949922899;5.7163314219569;1.8037955765284257;0.2627870160326081;5.283202187008149;HELO_1894;YcfJ family protein;COG3134;Uncharacterized conserved protein YcfJ, contains glycine zipper 2TM domain;YcfJ;HELO_RS04845;S;;puuB;;HELO_1894;YcfJ family protein;2.6392965800534247;0.04541266459058413;-0.16630825174669805;1.2484096217905565;-1.3908869582628682
HELO_1895;20.92673674941607;20.393344325334326;33.599002028319966;25.590837456139493;26.114113536702742;42.90514764859572;3.7209257566188354;2.4041350730734234;4.786417451956187;2.255955893598612;2.9065407470065447;9.75330924698086;HELO_1895;FdsD domain protein;;;;;;;;;HELO_1895;FdsD domain protein;0.03552908847294223;-0.3436596726672656;-0.6953460941675447;-1.0016989794791007;-1.037228067952043
HELO_1896;19.48283412243717;15.498532094929102;21.67402027492916;18.659366393677203;12.696860524324313;24.149852492897907;0.5330673351579654;1.4899103449921254;0.9508253206708559;1.2773184704131255;0.27847402121348314;0.42135761160415175;fdhD;sulfurtransferase FdhD;COG1526;Formate dehydrogenase assembly factor FdhD, a sulfurtransferase;FdhD;HELO_RS04855;C;fdhD; sulfurtransferase FdhD;;fdhD;sulfurtransferase FdhD;0.31207767779068973;-0.1495097239859362;-0.8767046894418238;-0.29613458975275186;-0.6082122675434416
HELO_1897;18.8580648871709;19.46399284187012;36.489593033989244;34.2326706006856;20.232286485236287;38.796815666568214;1.1767491634446396;0.7800508637291897;2.3047549568346857;2.396604254288754;1.9415556928140465;3.1692609192234604;HELO_1897;homolog to NADH-quinone oxidoreductase subunit NuoG;COG3383;Predicted molibdopterin-dependent oxidoreductase YjgC;YjgC;HELO_RS04860;R;;fdhD;1.17.1.9;HELO_1897;homolog to NADH-quinone oxidoreductase subunit NuoG;-0.043362621566949144;-0.08616283383916556;-0.9063932563613681;-1.002927955338448;-0.9595653337714989
HELO_1898;31.498176598977654;26.502055793079506;57.28931718874829;51.940457904117125;24.217559539975127;61.679126871591954;1.4585706205811457;2.366499925937201;8.847175922514433;1.871510952382503;0.36263605439917274;3.107042165498774;HELO_1898;homolog to NADH-quinone oxidoreductase subunit NuoF;COG1894;NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F);NuoF;HELO_RS04865;C;;;;HELO_1898;homolog to NADH-quinone oxidoreductase subunit NuoF;0.24081930909633265;-0.10475358125900591;-1.3135564191678561;-0.9476263090458517;-1.1884456181421843
HELO_1899;19.744679519613193;20.111057162758527;41.65808612099367;34.96739233787425;11.071210566535152;43.239909763877506;1.2032545307644176;2.2892588597143924;10.68239569318498;5.559281821678599;1.2405804851894109;2.4645697936353606;HELO_1899;homolog to NADH-quinone oxidoreductase subunit NuoE;COG1905;NADH:ubiquinone oxidoreductase 24 kD subunit (chain E);NuoE;HELO_RS04870;C;;;;HELO_1899;homolog to NADH-quinone oxidoreductase subunit NuoE;-0.025257455788164407;-0.05252920310454989;-1.8737780782714317;-1.092607073435409;-1.0673496176472446
HELO_1900;18.164169827381695;17.562938966476683;23.219421255130385;29.072338137707828;20.404312480389667;22.543906207560216;0.9058424973565496;0.6538090483756687;4.325452592574876;1.8439499417023817;1.803312791787269;1.7492379770666824;HELO_1900;HTH/PBP domain protein;COG2005;DNA-binding transcriptional regulator ModE (molybdenum-dependent);ModE;HELO_RS04875;K;;;;HELO_1900;HTH/PBP domain protein;0.045986360990262654;0.04081069084505362;-0.13745220407076442;-0.2969421967129309;-0.3429285577031935
HELO_1901;5.142129354632279;4.977065542042754;28.937365542473618;15.763475699377693;61.06797155009229;33.63108104807515;0.5249833364376367;0.36257803799894406;2.5567362125994983;1.180576893755875;3.7782270320353075;4.737502773903572;HELO_1901;NhaC family sodium/proton antiporter domain protein;COG1757;Na+/H+ antiporter NhaC/MleN;NhaC;HELO_RS04880;C;;;;HELO_1901;NhaC family sodium/proton antiporter domain protein;0.03930153326654384;-0.21012015228847325;0.8417815742376167;-2.495256622353513;-2.534558155620057
HELO_1902;29.441089429803498;15.342658198163749;47.87191599851098;40.16902756325676;73.41036325392099;46.91356187470635;1.743017761815957;0.5067537176408282;2.28475287387483;1.4521264183732745;4.601754628195492;2.6655700768249275;puuA;glutamate--putrescine ligase;COG0174;Glutamine synthetase;GlnA;HELO_RS04885;E;puuA; glutamate--putrescine ligase;6.3.1.2;puuA;glutamate--putrescine ligase;0.8973773284902142;0.02857159899608508;0.6350694950226181;-0.6544140756900507;-1.551791404180265
HELO_1903;91.07409050099314;85.37831057073068;105.08232655584932;89.0773326996234;113.8618567428454;98.02101217961784;2.5012295638960107;10.27593889428985;7.712929508961046;3.3034198303898057;3.676381822674444;9.097739634026434;puuD;gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD;COG2071;Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (putrescine degradation), contains GATase1-like domain;PuuD;HELO_RS04890;E;puuD; gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD;;puuD;gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD;0.09212614150734844;0.09937772000520617;0.2140931866771778;-0.10493945501969648;-0.19706559652704492
HELO_1904;52.040133869993916;65.64190630927469;72.83067829320113;65.22333808763081;89.04076573233608;72.87841557264308;2.3736985260679893;1.547815001438628;4.969270879573015;3.080035917241121;3.887970293362359;7.022401152172482;spuC;putrescine aminotransferase;COG0161;Adenosylmethionine-8-amino-7-oxononanoate aminotransferase;BioA;HELO_RS04895;H;spuC; putrescine aminotransferase;2.6.1.113;spuC;putrescine aminotransferase;-0.3293452532376726;-0.0009325131840132173;0.28542539992236016;-0.4780685092842063;-0.1487232560465337
HELO_1906;58.62508549254307;55.704552100706444;196.407919224029;152.29674128941141;202.9230647080366;193.01348891501428;3.327393704343728;2.3398923506778067;5.341811831825302;10.628474309601087;19.191369275068332;4.378125586365427;puuR1;PuuR family transcription regulator PuuR;COG1396;Transcriptional regulator, contains XRE-family HTH domain;HipB;HELO_RS04905;K;puuR1; PuuR family transcription regulator PuuR;;puuR1;PuuR family transcription regulator PuuR;0.07245487391279415;0.025022905949509955;0.07186800031567486;-1.7021656253988695;-1.7746204993116637
HELO_1907;56.7338415373022;95.38336392198407;423.5834039307017;365.702577326342;439.62466004451113;434.48404210896814;4.580468357374227;4.65057308494752;18.884735740391356;9.820532651663026;15.243209262572883;24.162434497409645;gatB;aspartyl-tRNA amidotransferase subunit B;COG0064;Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit;GatB;HELO_RS04910;J;gatB; aspartyl-tRNA amidotransferase subunit B;6.3.5.6,6.3.5.7;gatB;aspartyl-tRNA amidotransferase subunit B;-0.7393669304922277;-0.03657187318933097;0.016930385685629545;-2.915130724861788;-2.1757637943695602
HELO_1908;201.6609152369389;252.15862864734143;475.45337667373184;419.7040986644113;525.7121420683583;519.7188820581908;13.45290533040558;5.016983143771325;19.21013926675815;18.7613076131666;21.03697190823519;40.86403908603839;gatA;aspartyl-tRNA amidotransferase subunit A;COG0154;Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase;GatA;HELO_RS04915;J;gatA; aspartyl-tRNA amidotransferase subunit A;6.3.5.6,6.3.5.7;gatA;aspartyl-tRNA amidotransferase subunit A;-0.3209737773757233;-0.1281696758157409;0.016509995711318837;-1.3614368415287883;-1.040463064153065
HELO_1909;155.71746859924988;162.5722305555742;314.0915437513586;247.9619448735648;322.0501446379206;325.86305297114023;14.818791524454266;39.89107444716273;28.087258163151727;15.391725953862645;11.329564251363447;45.588739448624885;gatC;aspartyl-tRNA amidotransferase subunit C;COG0721;Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit;GatC;HELO_RS04920;J;gatC; aspartyl-tRNA amidotransferase subunit C;6.3.5.6,6.3.5.7;gatC;aspartyl-tRNA amidotransferase subunit C;-0.06176184503683402;-0.05291527436470567;-0.016928190032762913;-1.060520311432498;-0.9987584663956639
HELO_1910;1261.9190187404172;652.3642041817433;1017.9693599869221;972.291283643469;928.1931789904855;1069.5418953329436;47.20501110019091;22.464051433724656;65.72259710408953;25.354340137779293;47.317198484597235;41.4746565116516;mreB;rod shape-determining protein MreB;COG1077;Cell shape-determining ATPase MreB, actin-like superfamily;MreB;HELO_RS04925;DZ;mreB; rod shape-determining protein MreB;;mreB;rod shape-determining protein MreB;0.9508028119584857;-0.07123058538569538;-0.20429078748107798;0.23842087691963698;-0.7123819350388487
HELO_1911;491.9617579840687;313.0401119944775;228.01800993513214;223.28436441404276;190.78963050253432;213.7494116363581;15.642508810329883;8.895284277791632;21.82460978042045;22.332257571469725;9.919758237723226;26.06102208338094;mreC;rod shape-determining protein MreC;COG1792;Cell shape-determining protein MreC;MreC;HELO_RS04930;DZ;mreC; rod shape-determining protein MreC;;mreC;rod shape-determining protein MreC;0.6505268876702619;0.0928068773431594;-0.16312945850358673;1.1988215536719204;0.5482946660016585
HELO_1912;160.56838735255297;116.44556715002177;79.15242320517821;91.10895060758595;78.46893907818543;83.54985531563675;2.8229191428881095;5.321340244330561;7.186187118319739;13.126202182721087;4.0013132767140895;13.69541283866082;mreD;rod shape-determining protein MreD;COG2891;Cell shape-determining protein MreD;MreD;HELO_RS04935;M;mreD; rod shape-determining protein MreD;;mreD;rod shape-determining protein MreD;0.4601526849248456;-0.07705614858862386;-0.08941120148229853;0.934270755446418;0.4741180705215724
HELO_1913;274.7786633232872;174.16343999835908;158.36302085600173;162.7530969408211;139.10984304802466;143.80395268400756;22.298579550646288;1.0411218444926367;13.639039725728068;1.9054856360305148;7.356578681457565;19.782225641282498;yhdE;Maf family protein YhdE;COG0424;7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily;Maf;HELO_RS04940;Q;yhdE; Maf family protein YhdE;;yhdE;Maf family protein YhdE;0.6548091535511178;0.1382159163273302;-0.04754267184175287;0.9294098576089738;0.27460070405785597
HELO_1914;170.60677012583434;111.55121759000968;153.91119285124856;155.0660612214964;169.64042939570666;152.40217380595664;3.6868442432985824;4.584300306029455;9.765209244987043;7.174369117285004;15.630127198852476;14.647249466379222;rng;ribonuclease G;COG1530;Ribonuclease G or E;CafA;HELO_RS04945;J;rng; ribonuclease G;3.1.26.-;rng;ribonuclease G;0.6085248061951125;0.014122460542174586;0.15364057427264566;0.16178754339862955;-0.44673726279648296
HELO_1915;137.0995676027893;82.35310648883443;109.99790529357453;143.3188094276193;111.82815871016464;107.81926696995815;5.74748926091216;1.4238048591509995;5.5619909597685515;1.4341493819876543;2.207874677932042;3.1205109145420358;HELO_1915;DUF3971 domain protein;COG3164;Uncharacterized conserved protein YhdP, contains DUF3971 and AsmA2 domains;YhdR;HELO_RS04950;S;;rng;;HELO_1915;DUF3971 domain protein;0.7284009292860754;0.02859843565159359;0.052193153223009325;0.3437747872085639;-0.38462614207751145
HELO_1916;310.32899602459844;354.19589095483053;469.263569446953;476.57272895434994;403.3016939368585;460.00761008115296;8.371269247391666;26.241531165821947;28.044490432929436;13.002536465236016;29.064913541936836;6.00123670662381;tldD;metalloprotease TldD;COG0312;Zn-dependent protease PmbA/TldA or its inactivated homolog;TldD;HELO_RS04955;R;tldD; metalloprotease TldD;;tldD;metalloprotease TldD;-0.19017494180908834;0.028679007155490766;-0.18935831793021052;-0.5663506158191609;-0.37617567401007257
HELO_1917;132.0029872479071;82.47116285732785;150.89874920509274;177.07165372124754;176.01495938286203;151.35451230764156;4.602801367191957;7.248325091148383;7.97227269590627;9.182836686551031;15.742040088521216;8.523945835684529;HELO_1917;UPF0307 family protein;COG3028;Ribosomal 50S subunit-associated protein YjgA, DUF615 family;YjgA;HELO_RS04960;J;;tldD;;HELO_1917;UPF0307 family protein;0.6721088743342793;-0.004322239021610663;0.2164390572006898;-0.19597358015413047;-0.8680824544884098
HELO_1918;315.75130648963363;307.7388001598676;366.5996882574212;354.039974380119;326.36828174044416;325.7167779276328;1.8959024084563736;20.559487258247458;9.61311490005258;17.92739487424155;20.41447502887244;7.739671451071766;tldE;metalloprotease TldE;COG0312;Zn-dependent protease PmbA/TldA or its inactivated homolog;TldD;HELO_RS04965;R;tldE; metalloprotease TldE;;tldE;metalloprotease TldE;0.036963767702200556;0.17009499957372398;0.002874004280664977;-0.044689973580894105;-0.08165374128309466
HELO_1919;75.45000652574022;51.789255803291475;39.69464029142499;29.320778785514165;47.65893228966116;36.175305845217984;8.464398184485379;1.4983370343697575;1.9605235682752873;2.9485940781916553;1.427175360552409;2.414002958779282;ptsO;phosphocarrier protein NPr;COG1925;HPr or related phosphotransfer protein;PtsH;HELO_RS04970;TG;ptsO; phosphocarrier protein NPr;;ptsO;phosphocarrier protein NPr;0.5342722969801406;0.1304941845762384;0.3883600524073678;1.0401720132009729;0.5058997162208323
HELO_1920;205.97102883848052;125.66724683969922;107.2366499016703;79.68605498051943;131.49681869090264;126.17248181471733;13.443767024050965;3.3440260167689;3.8289559048802526;5.28530791196427;5.869242991886908;3.5400370903255483;HELO_1920;RapZ family nucleotide-binding protein;COG1660;RNase adaptor protein RapZ for GlmZ sRNA degradation, contains a P-loop ATPase domain;RapZ;HELO_RS04975;T;;ptsO;;HELO_1920;RapZ family nucleotide-binding protein;0.708385312072541;-0.23259743580424974;0.05917119313381569;0.7026423106965272;-0.005743001376013801
HELO_1921;611.5157577577977;302.27239163484745;261.09644175200407;229.61579615572802;314.8186411390752;299.4619340380114;62.38262587675955;22.274362111590513;7.812234322923312;8.0332053219529;19.989731547282993;22.04230142059424;ptsN;nitrogen regulatory protein PtsN;COG1762;Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type);PtsN;HELO_RS04980;TG;ptsN; nitrogen regulatory protein PtsN;2.7.1.-;ptsN;nitrogen regulatory protein PtsN;1.0141327914102884;-0.19708445774386973;0.07191410316105973;1.0275647344148364;0.013431943004547975
HELO_1922;507.49460309909927;244.71475396078577;63.65302378934459;53.720761022324474;42.36338351203137;41.98245678326587;30.51426338635012;62.75423880821158;23.244921273221156;44.93332404356392;9.309042731124057;4.648329117594262;hpf;ribosome hibernation promoting factor;COG1544;Ribosome-associated translation inhibitor RaiA;RaiA;HELO_RS04985;J;hpf; ribosome hibernation promoting factor;;hpf;ribosome hibernation promoting factor;1.049247975106245;0.5889698993164423;0.012729383742947853;3.5644126106091107;2.515164635502866
HELO_1923;98.92907897530108;72.86045950885212;67.3387215856305;56.534434747409506;54.82681751418502;63.281229745415395;4.305997644719448;1.4919807957626974;3.3696692814946894;2.939968894417796;1.4272455308836611;1.1234392699084486;rpoN;RNA polymerase sigma-54 factor;COG1508;DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog;RpoN;HELO_RS04990;K;rpoN; RNA polymerase sigma-54 factor;;rpoN;RNA polymerase sigma-54 factor;0.43610231976141733;0.088305730429167;-0.20343921344043192;0.6365070287325603;0.20040470897114293
HELO_1924;173.3564691865121;92.0161844669489;90.93839624937563;72.75830907801077;110.0960405410929;97.47635894262231;3.6157816595598784;3.7343946895714613;6.197432654755617;1.5239492573124165;0.7171837781378415;5.998995990370712;lptB;lipopolysaccharide export system ATP-binding protein LptB;COG1137;ABC-type lipopolysaccharide export system, ATPase component;LptB;HELO_RS04995;M;lptB; lipopolysaccharide export system ATP-binding protein LptB;7.5.2.5;lptB;lipopolysaccharide export system ATP-binding protein LptB;0.9064862270436338;-0.09910992035311317;0.17395807421882914;0.8241905679150072;-0.08229565912862657
HELO_1925;276.5954861764581;163.1663996812051;125.79378479234008;102.36502752300551;140.7523316246618;135.81978862122375;10.809119935394175;5.7267404473442;12.332340643246521;9.618468075972197;11.832998636935175;15.13982237316503;lptA;lipopolysaccharide export system protein LptA;COG1934;Lipopolysaccharide export system protein LptA;LptA;HELO_RS05000;M;lptA; lipopolysaccharide export system protein LptA;;lptA;lipopolysaccharide export system protein LptA;0.7578252316766543;-0.10979287741028632;0.05109555939355559;1.020707203002135;0.26288197132548063
HELO_1926;158.72249250808588;112.9615525396395;149.35053655378366;136.9270351177024;146.3803482977934;161.00984406902776;14.521970864122146;4.902771495839941;6.78431789444732;15.718758997979561;4.982238148765203;2.9858568564686654;lptC;lipopolysaccharide export system protein LptC;COG3117;Lipopolysaccharide export system protein LptC;YrbK;HELO_RS05005;M;lptC; lipopolysaccharide export system protein LptC;;lptC;lipopolysaccharide export system protein LptC;0.48702030959690124;-0.10775146060270036;-0.13653730881263737;-0.02051398618476874;-0.50753429578167
HELO_1927;161.484947450681;128.67064768728417;175.9230328063677;193.60940585553905;197.87732741578918;194.2030220402903;3.4303430714221315;6.262824610053517;10.81042168925488;27.890691950620887;6.144423056864932;3.1138054217687863;kdsC;3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC;COG1778;3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases;KdsC;HELO_RS05010;MR;kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC;3.1.3.45;kdsC;3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC;0.32545412618827907;-0.14185351001953528;0.02690342599284179;-0.2646693146298249;-0.590123440818104
HELO_1928;289.69780926639396;175.04939194947232;495.04459104287633;506.126575981378;496.38714977720156;511.96907995465955;15.66329202185759;9.526123387519371;24.539986138051948;6.493549547646813;51.42367352284878;36.85329496830819;kdsD;arabinose 5-phosphate isomerase KdsD;COG2905;Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains;;HELO_RS05015;T;kdsD; arabinose 5-phosphate isomerase KdsD;5.3.1.13;kdsD;arabinose 5-phosphate isomerase KdsD;0.7235399548537638;-0.0484020527273028;-0.0445026323087685;-0.8193516684717714;-1.5428916233255352
HELO_1929;201.89702745097875;88.02753200548761;158.92076155287015;144.6902058061195;133.13315803119323;172.28277520886402;11.246956105902873;2.895692420735886;18.464494509291487;0.4128398851963031;9.428178274896867;3.7130140023219287;mlaF;ABC-type transport system ATP-binding protein (probable substrate phospholipid);COG1127;ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla;MlaF;HELO_RS05025;M;mlaF; ABC-type transport system ATP-binding protein (probable substrate phospholipid);;mlaF;ABC-type transport system ATP-binding protein (probable substrate phospholipid);1.1884242614583043;-0.11577100629711623;-0.36946233478693635;0.22761947528769433;-0.9608047861706099
HELO_1930;300.27678840178976;168.8136124200905;219.17148401963615;210.7370037790482;178.0983255395878;224.03331389716143;14.202545253645255;4.574486141860345;3.1835762777643124;2.432952174510867;6.606631665796679;11.046232184808636;mlaE;probable ABC-type transport system permease protein (probable substrate phospholipid);COG0767;Permease subunit MlaE of the ABC-type intermembrane phospholipid transporter Mla;MlaE;HELO_RS05030;M;mlaE; probable ABC-type transport system permease protein (probable substrate phospholipid);;mlaE;probable ABC-type transport system permease protein (probable substrate phospholipid);0.8271374147487487;-0.031510966334958646;-0.32938674453885586;0.42095093247214166;-0.40618648227660703
HELO_1931;274.91043798622934;126.58978621745403;118.87476708163858;111.52509442681412;108.27987395334901;118.94337709490196;10.084099538084159;3.923519941833275;5.988183004214812;11.641426739365343;7.647134364313997;9.256448812311433;mlaD;ABC-type transport system periplasmic substrate-binding protein (probable substrate phospholipid);COG1463;Periplasmic subunit MlaD of the ABC-type intermembrane phospholipid transporter Mla;MlaD;HELO_RS05035;M;mlaD; ABC-type transport system periplasmic substrate-binding protein (probable substrate phospholipid);;mlaD;ABC-type transport system periplasmic substrate-binding protein (probable substrate phospholipid);1.1126871929184583;-0.0008254865696741831;-0.13432577394470346;1.2018465377771488;0.08915934485869048
HELO_1932;352.85641980759937;311.08300106868023;241.6384169456039;342.06097432247515;255.60601472758972;257.0609164322516;19.56658502744678;19.421911637257548;5.459304616135999;24.046434606471674;11.783015978228912;18.52402966991751;mlaC;phospholipid-binding protein MlaC;COG2854;Periplasmic subunit MlaC of the ABC-type intermembrane phospholipid transporter Mla;MlaC;HELO_RS05040;M;mlaC; phospholipid-binding protein MlaC;;mlaC;phospholipid-binding protein MlaC;0.18123431663783762;-0.08890366998024302;-0.008156673523789237;0.45545243303880767;0.27421811640097005
HELO_1933;592.0220519019284;397.51100737744554;154.60811477303577;187.77298387714723;176.58245226200245;185.2308915147107;23.87309453745582;26.708372219954153;14.798837026259934;15.771830259861177;15.49759044792103;16.274084766171136;HELO_1933;STAS domain protein;COG3113;Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain;MlaB;HELO_RS05045;M;;mlaC;;HELO_1933;STAS domain protein;0.573466179475222;-0.2591751063243839;-0.06860337398801963;1.6709933499071452;1.0975271704319232
HELO_1934;221.89474596043905;199.01470528992596;187.75577018843555;183.37797492489491;152.65744320428342;183.8202567395517;10.810128851323007;23.119020376247576;32.24129846694554;14.260356253888897;18.246555828736074;21.169452436872746;HELO_1934;BolA family protein;COG5007;Acid stress protein IbaG/YrbA, BolA-like family;IbaG;HELO_RS05050;T;;;;HELO_1934;BolA family protein;0.15625653767528647;0.03039785949604923;-0.2664052351008195;0.2702397217935948;0.11398318411830832
HELO_1935;389.6606469903322;429.7994104141958;393.5646572638829;469.0300573661796;372.71455847969855;410.8158062966977;25.974656219007237;21.537545482219688;6.872967416852092;27.140039864566425;25.59338444011722;12.119690814058707;murA;UDP-N-acetylglucosamine 1-carboxyvinyltransferase;COG0766;UDP-N-acetylglucosamine enolpyruvyl transferase;MurA;HELO_RS05055;M;murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase;2.5.1.7;murA;UDP-N-acetylglucosamine 1-carboxyvinyltransferase;-0.14110034177214636;-0.06173747061458279;-0.14006243783722994;-0.07608327083245214;0.06501707093969422
HELO_1936;294.9176443930446;262.379313387596;180.83436573955748;238.74762787111595;179.7558627390499;206.33050752311604;12.871057363909964;5.142315672193371;6.812029532716731;21.45998337136656;11.74693996088466;13.574938445566998;hisG;ATP phosphoribosyltransferase catalytic subunit;COG0040;ATP phosphoribosyltransferase;HisG;HELO_RS05060;E;hisG; ATP phosphoribosyltransferase catalytic subunit;2.4.2.17;hisG;ATP phosphoribosyltransferase catalytic subunit;0.16805368488059536;-0.18930752948093232;-0.19788997543167675;0.5132633047048136;0.3452096198242183
HELO_1937;381.2778831428748;401.82199194634273;356.68222620117166;402.81837714688635;354.46686655804416;334.88422116657046;6.131322582772783;31.13591517743619;7.776331072272363;1.8879234879576905;6.521585434447661;5.723819690154589;hisD;histidinol dehydrogenase;COG0141;Histidinol dehydrogenase;HisD;HELO_RS05065;E;hisD; histidinol dehydrogenase;1.1.1.23;hisD;histidinol dehydrogenase;-0.07552071417658901;0.09071440662489216;0.08175106730581128;0.186657711145374;0.262178425321963
HELO_1938;56.08704485046811;64.4094624827069;71.17916373579165;71.3677937718709;80.96922274686467;72.61577767397117;1.9084503719120474;2.06971937883485;8.930642670202744;1.200543212360484;6.182242979519453;5.67028808984865;degP2;serine endoprotease DegP;COG0265;Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain;DegQ;HELO_RS05070;O;degP2; serine endoprotease DegP;3.4.21.-;degP2;serine endoprotease DegP;-0.19633597662223856;-0.02843257615747241;0.1550673134619016;-0.3668516223159841;-0.17051564569374555
HELO_1939;118.84021816399063;108.83611659336707;95.30035640409183;102.52656035089736;110.74335075100213;100.53395645619538;4.523164876827059;3.9520086738435882;5.616166231364465;7.873615548730008;4.406614702060888;14.089204984192715;ybgI;GTP cyclohydrolase domain protein YbgI;COG0327;Putative GTP cyclohydrolase 1 type 2, NIF3 family;NIF3;HELO_RS05075;H;ybgI; GTP cyclohydrolase domain protein YbgI;;ybgI;GTP cyclohydrolase domain protein YbgI;0.1257596322399479;-0.07634925252539926;0.13822669182074154;0.23914986019814233;0.11339022795819442
HELO_1940;164.68855449473668;111.94218339748403;111.19112438938714;122.7074022537743;96.17960804352246;112.53984645913692;4.659453981133112;2.6127940562182483;2.3499880880144746;5.201914827108058;1.468983325901082;6.698378164198688;zapE;cell division protein ZapE;COG1485;Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily;ZapE;HELO_RS05085;D;zapE; cell division protein ZapE;;zapE;cell division protein ZapE;0.5528895200208535;-0.017240149097888846;-0.2244731770299433;0.5452752511340835;-0.00761426888676997
HELO_1941;3061.2073912636456;3601.1794618809313;3287.0329492258693;3559.9798242857396;2953.387206495561;3461.1284240839373;81.85160605546199;202.4339757236323;93.24596668264199;306.09932663608186;239.18478423923776;72.55755888104753;rplM;50S ribosomal protein L13;COG0102;Ribosomal protein L13;RplM;HELO_RS05090;J;rplM; 50S ribosomal protein L13;;rplM;50S ribosomal protein L13;-0.23429806441446388;-0.0744344847098315;-0.2288003206740239;-0.17708724677416932;0.057210817640294565
HELO_1942;4099.857464181637;3642.031713341661;2114.8531747625675;2041.6828243701505;2162.1692985812933;2194.5998211005017;175.63467678405175;171.84973011541294;233.53445508779853;330.27614854677336;66.45608522834294;346.4034928316815;rpsI;30S ribosomal protein S9;COG0103;Ribosomal protein S9;RpsI;HELO_RS05095;J;rpsI; 30S ribosomal protein S9;;rpsI;30S ribosomal protein S9;0.17078604587749346;-0.05337560877421588;-0.02146854587011582;0.9013104730974408;0.7305244272199474
HELO_1943;101.50848857796473;46.193980433004896;81.31593119529653;108.58212552101124;102.4789873112187;80.12106616960011;7.740649586916684;2.7994776464415603;6.191329387904275;3.672004018470832;13.14205857549203;2.507514511047738;petA;ubiquinol-cytochrome c reductase iron-sulfur subunit;COG0723;Rieske Fe-S protein;QcrA/PetC;HELO_RS05100;C;petA; ubiquinol-cytochrome c reductase iron-sulfur subunit;7.1.1.8;petA;ubiquinol-cytochrome c reductase iron-sulfur subunit;1.1190686206906406;0.021095059110876946;0.3511893215473716;0.3375948633049699;-0.7814737573856707
HELO_1944;23.474933443427215;20.702274475046554;26.12435698391583;35.61646980666977;35.289944396946986;23.88278352554289;0.9217457244073981;1.8929286007215136;2.310774157706113;0.1262818563259392;3.3600451282872066;1.4527414694025682;petB;ubiquinol--cytochrome c reductase cytochrome b subunit;COG1290;Cytochrome b subunit of the bc complex;QcrB/PetB;HELO_RS05105;C;petB; ubiquinol--cytochrome c reductase cytochrome b subunit;;petB;ubiquinol--cytochrome c reductase cytochrome b subunit;0.17345868647123996;0.1244410547821646;0.5444219640090511;-0.02384294572594925;-0.19730163219718921
HELO_1945;29.04223430839674;22.525120575115867;25.77573470050731;39.23461146400755;37.520428888122915;21.673573801079527;1.580240036557114;2.0972030808159374;2.86488391096231;1.7233218710385383;2.2440719880467443;1.9840546972949873;petC;ubiquinol-cytochrome c reductase cytochrome c1 subunit;COG2857;Cytochrome c1;CYT1;HELO_RS05110;C;petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit;;petC;ubiquinol-cytochrome c reductase cytochrome c1 subunit;0.3527899959817269;0.23991435557936036;0.7646119601908286;0.4059803072016992;0.05319031121997231
HELO_1946;700.4257804177481;673.3903367068361;877.0599314666429;613.5563224238604;691.3615093986122;849.2490394720697;14.763715302238122;37.613277175611785;92.13107355565;24.179269587120356;18.988460722942072;17.689324061358555;sspA;stringent starvation protein SspA;COG0625;Glutathione S-transferase;GstA;HELO_RS05115;O;sspA; stringent starvation protein SspA;;sspA;stringent starvation protein SspA;0.05670659267095424;0.04643394230807374;-0.29635994823867406;-0.2775950142985959;-0.33430160696955014
HELO_1947;984.1322715741817;1016.8179404501724;550.2941742580704;396.92125855758445;440.9735842920454;553.319438560634;57.479188053963846;105.46424563516216;48.00769490208328;1.9399145025883684;16.682009704248884;20.236007547009795;sspB;stringent starvation protein SspB;COG2969;Stringent starvation protein B, binds SsrA peptide;SspB;HELO_RS05120;O;sspB; stringent starvation protein SspB;;sspB;stringent starvation protein SspB;-0.047090175926784994;-0.007895244141092661;-0.3267574543773133;0.8295998449837771;0.8766900209105621
HELO_1948;196.35169553614045;113.03012261453556;173.98518512461763;276.2240303478475;196.4671039638565;179.9053524248285;20.891057633804493;3.515855080335478;13.98906332497306;13.661237650465877;14.522971838506097;8.064861504045382;HELO_1948;BON domain protein;COG2823;Phospholipid-binding membrane integrity protein DolP/YraP/OsmY, contains BON domain;OsmY;HELO_RS05125;M;;sspB;;HELO_1948;BON domain protein;0.7913539317801641;-0.04800230995988475;0.12637724136857464;0.12553382068396868;-0.6658201110961954
HELO_1949;174.71378118202304;104.81261726446212;152.2952972127404;283.0526335676587;180.07603679909695;165.882577689805;14.2620392824409;5.961937008123308;13.755629829482286;24.844384078650176;11.109241738299682;9.948500481946942;gmhA;phosphoheptose isomerase;COG0279;Phosphoheptose isomerase;GmhA;HELO_RS05130;G;gmhA; phosphoheptose isomerase;5.3.1.28;gmhA;phosphoheptose isomerase;0.7317156789903203;-0.12251990846364702;0.11776228866378169;0.07439399875060104;-0.6573216802397193
HELO_1950;92.18658142995021;64.52731787184392;20.219969965996235;23.03046590648856;22.395379327585356;20.38102939532466;6.4001869683798995;4.278840293137703;6.164666818185107;0.4903542438488645;0.9817587841298188;2.7257009552114013;HELO_1950;UPF0102 family protein;COG0792;Predicted endonuclease distantly related to archaeal Holliday junction resolvase, YraN/UPF0102 family;YraN;HELO_RS05135;L;;gmhA;;HELO_1950;UPF0102 family protein;0.5080257450218282;-0.010908699351480422;0.1298923067655906;2.1237909126925194;1.6157651676706912
HELO_1951;185.82595180815744;168.91189070809878;356.57848267933304;360.1009159518633;377.8557275585329;351.8698894363006;16.053528960731587;2.612334180916982;5.599475826773849;10.908270773924299;47.30837190133058;27.562543472811694;HELO_1951;LpoA family protein;COG3107;Outer membrane lipoprotein LpoA, binds and activates PBP1a;LpoA;HELO_RS05140;M;;;;HELO_1951;LpoA family protein;0.13690805412840845;0.01912359533382002;0.1025122293046472;-0.9174414571733402;-1.0543495113017487
HELO_1952;130.19418643171983;108.20382927619316;148.01530931182654;185.31692797702047;169.59700176723445;128.78143988576153;6.068941843078442;1.218864757910262;18.50714331863435;28.331482428780863;27.626168887792144;9.26289691428168;rsmI;16S rRNA (cytidine(1402)-2'-O)-methyltransferase RsmI;COG0313;16S rRNA C1402 (ribose-2'-O) methylase RsmI;RsmI;HELO_RS05145;J;rsmI; 16S rRNA (cytidine(1402)-2'-O)-methyltransferase RsmI;2.1.1.198;rsmI;16S rRNA (cytidine(1402)-2'-O)-methyltransferase RsmI;0.26468034583708455;0.19937647825862292;0.3945082141074181;0.01561971417672936;-0.2490606316603552
HELO_1953;444.65357359429936;363.15828171165066;326.02229517927015;486.71028173381484;343.813671893288;318.1132778705397;24.074203834552073;14.633639959688765;17.184209510370536;25.03822737260115;21.794080170211522;26.482532514593544;rsmH;16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH;COG0275;16S rRNA C1402 N4-methylase RsmH;RmsH;HELO_RS05155;J;rsmH; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH;2.1.1.199;rsmH;16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH;0.29135701919620693;0.03532035827729274;0.11174834010058632;0.4818540361337398;0.19049701693753285
HELO_1954;181.8160436082243;178.38917710960914;49.82704513314187;61.24886872703032;51.721770671576756;48.11011079907448;16.43154188484288;13.885919081291133;11.293106384800993;11.142582145262194;14.15536445118355;14.90251730910235;HELO_1954;FtsL family protein;COG3116;Cell division protein FtsL, interacts with FtsB and FtsQ;FtsL;HELO_RS05160;D;;rsmH;;HELO_1954;FtsL family protein;0.027299831936213437;0.04957628365678968;0.10237874691840876;1.8963007017166866;1.8690008697804732
HELO_1955;160.42863813143666;147.96900908940685;102.61994652208027;125.55295001149778;94.7348312708885;101.17972758088506;7.486576592100834;3.759000915159385;4.275891802456863;1.2764692081271285;4.56416838775512;7.043094831461562;ftsI;peptidoglycan synthase FtsI;COG0768;Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2);FtsI;HELO_RS05165;DM;ftsI; peptidoglycan synthase FtsI;3.4.16.4;ftsI;peptidoglycan synthase FtsI;0.11588431214024819;0.020192749612580663;-0.09399317243428928;0.6597875470788761;0.5439032349386279
HELO_1956;401.6694802948511;269.23944985532546;317.0621955121355;400.4564499660483;305.37136079332396;319.68755616868674;8.305426908279012;4.225613925905296;10.572982036296587;12.790825188649272;21.758773225265042;17.645276296040922;murE;UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase;COG0769;UDP-N-acetylmuramyl tripeptide synthase;MurE;HELO_RS05170;M;murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase;6.3.2.13;murE;UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase;0.5753578333438014;-0.011859468026163;-0.06588693084483843;0.32842775650120437;-0.24693007684259705
HELO_1957;364.8817656368433;198.28608627137427;250.33756124864848;289.32309079886255;229.9692137831305;234.53009592207957;11.205843883351083;4.929935476419295;8.524807605072468;9.42815021540318;18.42250296214848;20.856995137778664;murF;UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase;COG0770;UDP-N-acetylmuramyl pentapeptide synthase;MurF;HELO_RS05175;M;murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase;6.3.2.10;murF;UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase;0.8765365304078312;0.09371487301060455;-0.028210852923019836;0.6354660997229029;-0.24107043068492828
HELO_1958;272.059627747084;193.39718121623991;191.06458403893552;213.46536820823255;154.0742230121795;189.88770130073775;17.062482925257036;7.11214130908684;4.08347472617944;6.311603797661177;5.629721694320939;16.46045582983979;mraY;phospho-N-acetylmuramoyl-pentapeptide-transferase;COG0472;UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase;Rfe;HELO_RS05180;M;mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase;2.7.8.13;mraY;phospho-N-acetylmuramoyl-pentapeptide-transferase;0.490208725529631;0.00886736181153669;-0.29976525795895803;0.5164918709931836;0.026283145463552593
HELO_1959;412.4531722489612;234.2926653157148;218.13022003991622;264.65357635438016;220.97726021562403;205.95492072385716;20.079903085647715;7.983261996900968;11.120571617276779;3.1210048421892176;17.83164653260582;7.348929206878315;murD;UDP-N-acetylmuramoylalanine--D-glutamate ligase;COG0771;UDP-N-acetylmuramoylalanine-D-glutamate ligase;MurD;HELO_RS05185;M;murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase;6.3.2.9;murD;UDP-N-acetylmuramoylalanine--D-glutamate ligase;0.8132675901458866;0.08247190711330266;0.10109534001109832;0.9984073872185055;0.18513979707261896
HELO_1961;106.06296284124915;57.72599152787899;60.365443550032296;75.28618402384285;60.484384195460514;63.98252583624849;7.626818791471961;2.4678714811142517;2.347607037987219;3.793672977860645;3.3189818000941793;8.46524406696192;ftsW;probable lipid II flippase FtsW;COG0772;Peptodoglycan polymerase FtsW/RodA/SpoVE;FtsW;HELO_RS05190;D;ftsW; probable lipid II flippase FtsW;;ftsW;probable lipid II flippase FtsW;0.8663884112265077;-0.08262535574806318;-0.0798317802732802;0.7203357565425259;-0.14605265468398176
HELO_1962;250.4158530729018;161.33693848080782;207.98878986704048;244.9750036712111;197.22910825096588;193.28441877814421;7.9906986289853625;1.083716860393243;9.321203475957692;13.254292344742673;17.553059629367294;12.250718462675513;murG;UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;COG0707;UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase;MurG;HELO_RS05195;M;murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;2.4.1.227;murG;UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;0.6310843109920681;0.1052553540918515;0.02899862121559238;0.3719054177226564;-0.2591788932694117
HELO_1963;229.108718992485;196.33690011041529;222.0411310413473;265.896145158067;176.82778410607844;223.2554320554639;2.7949938673406525;2.3767165985945824;11.448407410497374;5.058912922555005;7.572057176203544;5.861637387121868;murC;UDP-N-acetylmuramate--L-alanine ligase;COG0773;UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family;MurC;HELO_RS05200;M;murC; UDP-N-acetylmuramate--L-alanine ligase;6.3.2.8;murC;UDP-N-acetylmuramate--L-alanine ligase;0.22165489795546733;-0.007833149187622013;-0.3346621806005743;0.03717271796796329;-0.18448217998750405
HELO_1964;285.01815990554843;229.5712516967293;177.22840808499677;196.04759353364315;152.24298479548085;155.96408734676933;9.35135499906571;7.683288890373018;18.833987562069794;28.27242885835286;10.533010872713435;3.4930823865113934;ddl;D-alanine--D-alanine ligase;COG1181;D-alanine-D-alanine ligase or related ATP-grasp enzyme;DdlA;HELO_RS05205;MR;ddl; D-alanine--D-alanine ligase;6.3.2.4;ddl;D-alanine--D-alanine ligase;0.31089410497708236;0.1832927934918347;-0.03461348366545103;0.8656722347541637;0.5547781297770813
HELO_1965;173.3471128495406;107.9332512279858;126.48683591439307;143.2556661789422;117.98908765114562;121.29268027110909;3.8709774191243786;5.671610715247153;5.449426653401069;3.9405285118174302;10.658298562018308;12.500586691773549;HELO_1965;FtsQ family protein;COG1589;Cell division septal protein FtsQ;FtsQ;HELO_RS05210;D;;ddl;;HELO_1965;FtsQ family protein;0.6785180782223614;0.0600102292941358;-0.03950878337189323;0.5116244184833354;-0.16689365973902603
HELO_1966;602.2870178221698;362.95921921541094;602.595155197164;662.5781957808999;511.2228704903999;555.021348741663;27.992306185123567;15.006342935613999;28.622998148739757;17.07798531406147;38.087229287946435;21.74506454348981;ftsA;cell division protein FtsA;COG0849;Cell division ATPase FtsA;FtsA;HELO_RS05215;D;ftsA; cell division protein FtsA;;ftsA;cell division protein FtsA;0.7290677283840594;0.11844094893674217;-0.11836860709926178;0.11770426016560087;-0.6113634682184586
HELO_1967;955.8608368837789;683.3882964404687;1099.33930712315;1126.9153179538862;1186.6404413038683;1072.2555653312231;53.221800833678735;32.88311562357863;50.55355636050893;28.092876355848997;94.17584362152576;19.027224239759878;ftsZ;cell division protein FtsZ;COG0206;Cell division GTPase FtsZ;FtsZ;HELO_RS05220;D;ftsZ; cell division protein FtsZ;;ftsZ;cell division protein FtsZ;0.4834940296502914;0.03595481646196319;0.14610447179514807;-0.16561263023198336;-0.6491066598822748
HELO_1968;937.8146247441414;551.83333946083;673.2138152648594;776.093392225776;717.880050781535;668.8106132423738;35.590313233394156;15.085550830615082;15.195048748257888;24.366604269810995;39.797958040195695;26.811786613549973;lpxC;UDP-3-O-acyl-N-acetylglucosamine deacetylase;COG0774;UDP-3-O-acyl-N-acetylglucosamine deacetylase;LpxC;HELO_RS05225;M;lpxC; UDP-3-O-acyl-N-acetylglucosamine deacetylase;3.5.1.108;lpxC;UDP-3-O-acyl-N-acetylglucosamine deacetylase;0.7639956938876242;0.009452953851759816;0.10199783295624698;0.4870870802408973;-0.2769086136467269
HELO_1969;83.22480978038065;55.99512017209609;72.30795110403301;87.65169996794214;94.76842889510556;72.14598624315965;4.842453475977941;3.972427936540572;7.030058595500705;6.706996449001888;4.723574141736572;1.3882337959036057;HELO_1969;DUF721 domain protein;COG4701;Uncharacterized conserved protein;;HELO_RS05230;S;;lpxC;;HELO_1969;DUF721 domain protein;0.563406861658045;0.003190982790542307;0.3887714330228791;0.20346656386743867;-0.3599402977906063
HELO_1970;366.5271473603543;323.8103635777656;405.0751153716135;558.1378744502202;402.46546979067347;448.84332107660885;35.47338736105432;30.554138326959503;27.868868458963554;13.700362551877573;21.90301574375949;40.7757020663183;HELO_1970;uncharacterized protein;;;;;;;;;HELO_1970;uncharacterized protein;0.1782531537495533;-0.14767598268201532;-0.1569773959736498;-0.2915717846471555;-0.4698249383967088
HELO_1971;180.86290695223462;199.30932101844397;380.80332191550633;395.8640819078232;436.6513405388561;381.66450180582416;5.953619858552239;7.954635878561813;27.412241755032365;7.407365952650351;48.69839947717403;29.46499715285344;secA;protein translocase subunit SecA;COG0653;Preprotein translocase subunit SecA (ATPase, RNA helicase);SecA;HELO_RS05240;U;secA; protein translocase subunit SecA;7.4.2.8;secA;protein translocase subunit SecA;-0.13937823720126108;-0.0032504192958189293;0.19370191509742085;-1.0732287557770066;-0.9338505185757455
HELO_1972;409.4866014914522;378.09154924331386;441.33008087178223;458.13293667255385;430.2981443862957;437.5040770387989;8.266668042150817;18.15305070253884;29.353671295230154;33.38936189286588;39.44373300896089;7.899284616195083;argJ;bifunctional ornithine acetyltransferase / N-acetylglutamate synthase;COG1364;Glutamate N-acetyltransferase (ornithine transacetylase);ArgJ;HELO_RS05245;E;argJ; bifunctional ornithine acetyltransferase / N-acetylglutamate synthase;2.3.1.35,2.3.1.1;argJ;bifunctional ornithine acetyltransferase / N-acetylglutamate synthase;0.11478883628460856;0.01253310040445399;-0.023904747298507445;-0.09525512393301483;-0.2100439602176234
HELO_1973;502.6413926363039;585.0752173847633;569.189217569367;490.3894914683206;437.82262011404356;568.5018624283676;22.85160648400435;22.95100906964267;32.31418757407921;7.399521828521101;25.30847178648681;21.28048669188704;HELO_1973;NUDIX family hydrolase / thiE domain protein;COG1051;ADP-ribose pyrophosphatase YjhB, NUDIX family;YjhB;HELO_RS05250;F;;argJ;3.6.1.55;HELO_1973;NUDIX family hydrolase / thiE domain protein;-0.21868897491193628;0.0017401978323530187;-0.3760626652840262;-0.177303701643023;0.04138527326891328
HELO_1974;154.16356354212476;59.25596586229221;104.31891720656613;84.34777751901764;85.3870338704316;104.59258839642384;12.373666252958254;0.592184014571283;13.042555789608869;4.847866520572671;1.4373951486991754;9.745396782909419;aguB;N-carbamoylputrescine amidase;COG0388;Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate;Nit2;HELO_RS05255;C;aguB; N-carbamoylputrescine amidase;3.5.1.53;aguB;N-carbamoylputrescine amidase;1.3646138219886872;-0.0037439805751535715;-0.28962188002088585;0.5552812401467113;-0.8093325818419759
HELO_1975;127.40536830412013;45.06237285249626;99.56331888035531;79.66271085881561;75.322046783858;109.75244845416906;11.269223156546628;4.148867956368146;6.363991979152463;3.2691606642148385;3.1588923440050576;10.67575231305574;HELO_1975;homolog to agmatine deiminase;COG2957;Agmatine/peptidylarginine deiminase;AguA;HELO_RS05260;E;;aguB;;HELO_1975;homolog to agmatine deiminase;1.4790448821501299;-0.13923442467528346;-0.5371668266632863;0.21336692571603066;-1.2656779564340992
HELO_1976;169.726788101727;158.34091108401867;156.86560304555982;168.68225504991952;133.46444804585096;179.4716637715087;1.390494565800029;2.275037017947449;10.802787485651754;13.982215126721492;12.442327150846639;8.583070988881895;lolC;ABC-type lipoprotein-releasing system transmembrane protein LolC;COG4591;ABC-type transport system involved in lipoprotein release, permease component LolC;LolE;HELO_RS05265;M;lolC; ABC-type lipoprotein-releasing system transmembrane protein LolC;;lolC;ABC-type lipoprotein-releasing system transmembrane protein LolC;0.0995727148714689;-0.19307547426123506;-0.42454755495243024;-0.08008289035784522;-0.17965560522931412
HELO_1977;222.66803571962728;221.46029602153487;228.9415377090079;222.18495123827475;188.87693764022052;240.31071162174786;10.703660870047546;15.407590816471792;20.17547452126723;13.57615903824155;2.4105948972288287;12.711393240860158;lolD;ABC-type lipoprotein-releasing system ATP-binding protein LolD;COG1136;ABC-type lipoprotein export system, ATPase component;LolD;HELO_RS05270;M;lolD; ABC-type lipoprotein-releasing system ATP-binding protein LolD;7.6.2.-;lolD;ABC-type lipoprotein-releasing system ATP-binding protein LolD;0.007811224733705657;-0.06962485250534911;-0.34582727015129944;-0.10953286090235537;-0.11734408563606102
HELO_1978;70.2067406639262;39.21914621529198;40.529344284927596;45.336701241614044;43.21906638974559;38.60040244351553;4.340961884147628;3.7251825613863483;6.202780141269094;5.294952334367337;3.3825140911765605;5.639548002328152;HELO_1978;DUF2062 family protein;COG3216;Uncharacterized conserved protein, DUF2062 family;;HELO_RS05275;S;;lolD;;HELO_1978;DUF2062 family protein;0.8241313619233592;0.06861600101477539;0.15915347349873077;0.8464987259778267;0.022367364054467487
HELO_1979;43.8269039875182;16.955671846279433;25.95524846854509;39.87386576141435;37.70044223991094;27.020935846437414;3.0167556869383683;0.5860718154845576;2.1463636389826;1.3261513259101478;2.1035927617361567;1.8103233157088165;HELO_1979;ComEC family protein;COG2333;DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily;ComEC;HELO_RS05280;U;;;;HELO_1979;ComEC family protein;1.3199252264881691;-0.05593893173918563;0.4658449126430835;0.6778597218648841;-0.642065504623285
HELO_1980;114.17990625103629;66.62094875494432;68.97612663074402;73.38288353560218;69.03929183955556;70.25626959815783;6.135404374961798;1.4871239225506672;3.541058666741138;2.3893498736678764;0.9865621996783088;5.8067789723934355;msbA;lipid A export ATP-binding/permease protein MsbA;COG1132;ABC-type multidrug transport system, ATPase and permease component;MdlB;HELO_RS05285;V;msbA; lipid A export ATP-binding/permease protein MsbA;7.5.2.6;msbA;lipid A export ATP-binding/permease protein MsbA;0.7683468896849472;-0.02615414791986659;-0.024852460710174107;0.6928001901678025;-0.07554669951714477
HELO_1981;222.02941230862598;153.4112998143714;160.92172183702596;233.83114163049615;185.22779746943968;164.29515120747485;13.456914879416734;5.089589944020602;9.685656210070448;2.491731965452765;6.158920877827915;5.120248675983333;lpxK;tetraacyldisaccharide 4'-kinase;COG1663;Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase);LpxK;HELO_RS05290;M;lpxK; tetraacyldisaccharide 4'-kinase;2.7.1.130;lpxK;tetraacyldisaccharide 4'-kinase;0.530455647222758;-0.02974786851834743;0.17202402919834636;0.4321895750523259;-0.09826607217043204
HELO_1982;147.7813912107887;115.5294039328818;115.32561037635212;143.98421820215015;124.12668875680804;117.76374565545537;10.09637280679713;5.609918210379736;9.012706787155398;11.977255192606616;6.91385101958071;14.60749048721854;HELO_1982;UPF0434 family protein;COG2835;RNA methyltransferase activator Trm112/YbaR;Trm112;HELO_RS05295;J;;lpxK;;HELO_1982;UPF0434 family protein;0.35250005616476887;-0.02992574276396276;0.07529504045029078;0.3250995931703695;-0.027400462994399355
HELO_1983;211.79265070870022;160.5917765217106;132.5422296098022;191.71580656897927;140.48223837142123;139.01814654408938;3.508455465279941;7.259428055182284;2.4033591287569465;16.591143392474006;2.767018704035322;4.700364050227079;kdsB;3-deoxy-manno-octulosonate cytidylyltransferase;COG1212;CMP-2-keto-3-deoxyoctulosonic acid synthetase;KdsB;HELO_RS05300;M;kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase;2.7.7.38;kdsB;3-deoxy-manno-octulosonate cytidylyltransferase;0.39709454429860536;-0.06831778188674065;0.015007134469716021;0.6038345103099179;0.2067399660113125
HELO_1984;162.58217384506176;118.25523571127337;142.14093326045887;174.25135743551778;145.68146850639656;143.93002117882762;1.3630063543057365;6.234517788446296;4.119098724516737;3.9457479484157485;2.847388613179731;4.467700823909589;murB;UDP-N-acetylenolpyruvoylglucosamine reductase;COG0812;UDP-N-acetylenolpyruvoylglucosamine reductase;MurB;HELO_RS05310;M;murB; UDP-N-acetylenolpyruvoylglucosamine reductase;1.3.1.98;murB;UDP-N-acetylenolpyruvoylglucosamine reductase;0.4559629341766138;-0.017920178442949464;0.017330145397012053;0.17465907160003802;-0.2813038625765758
HELO_1985;26.22681998022355;12.774054830444726;14.627037359920637;17.461815741075068;15.955967359753842;15.901637586404306;1.6849216779724991;0.9636227739975773;1.346634251767406;1.2453698429804911;0.46757565270494617;0.9708506946466166;HELO_1985;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS05315;K;;murB;;HELO_1985;LysR family transcription regulator;0.983075164201181;-0.1131187428590743;0.004630059449501012;0.6878654544277945;-0.29520970977338656
HELO_1986;8.170844391582866;5.2023936366387895;4.542076818705074;4.141234899986069;3.3876650898682876;3.686514868175399;1.2339657605426855;0.5400089147855666;0.4006129973640555;0.5826301559036304;0.2681583100791093;0.6647322634810777;HELO_1986;pirin domain protein;COG1741;Redox-sensitive bicupin YhaK, pirin superfamily;YhaK;HELO_RS05320;R;;;1.13.11.24;HELO_1986;pirin domain protein;0.5642294839943811;0.24191124840741018;-0.0950620505963391;0.9685391141520827;0.4043096301577016
HELO_1987;92.12841595347074;63.55153321033359;42.48493214227898;41.84616780481528;55.658481136833366;52.293547630694775;6.2152506950638635;3.0408028991815086;2.7279613492988717;1.8522263330797284;6.247452246044261;4.7725192348139265;ycaC;isochorismatase family hydrolase YcaC;COG1335;Nicotinamidase-related amidase;PncA;HELO_RS05325;HR;ycaC; isochorismatase family hydrolase YcaC;;ycaC;isochorismatase family hydrolase YcaC;0.5287700770991508;-0.29344529042036616;0.08833105418385401;0.8052605663018841;0.27649048920273334
HELO_1988;48.47129056743535;23.5781960088666;19.0724207313545;26.614984872801255;19.477473032962056;17.48901350642738;0.7540702802995484;0.932996754502454;3.7485956934961386;5.3849919525930146;1.367768760766544;1.336935310723095;HELO_1988;pirin domain protein;COG1741;Redox-sensitive bicupin YhaK, pirin superfamily;YhaK;HELO_RS05330;R;;ycaC;1.13.11.24;HELO_1988;pirin domain protein;1.0092125072364402;0.11854636518370487;0.14736944360664683;1.4199232850157886;0.4107107777793484
HELO_1989;202.46635360909866;310.4048551786425;535.9970511254246;552.8204009695522;556.6000112265834;533.3783592455876;8.016581282511805;21.620682143920366;22.978279149688806;12.160585450368478;39.77317160886583;28.54242031298372;rne;ribonuclease E;COG5271;Midasin, AAA ATPase with  vWA domain, involved in ribosome maturation;MDN1;HELO_RS05335;J;rne; ribonuclease E;3.1.26.12;rne;ribonuclease E;-0.61400119626198;0.007052581710704331;0.06136900617111429;-1.3930713423897272;-0.7790701461277472
HELO_1990;259.9572811065138;195.68196620078683;238.74191777576132;237.98990581064655;182.35450931991826;215.52595342256345;19.159624380245596;7.8360488013313585;2.4578860648370453;12.52044691459627;5.087062902245324;13.140951861581996;rluC;23S rRNA pseudouridine(955/2504/2580) synthase RluC;COG0564;Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific;RluA;HELO_RS05340;J;rluC; 23S rRNA pseudouridine(955/2504/2580) synthase RluC;5.4.99.24;rluC;23S rRNA pseudouridine(955/2504/2580) synthase RluC;0.40794897315991907;0.14694221877193847;-0.23990421355308822;0.26927369502701204;-0.13867527813290703
HELO_1991;265.6676501943016;201.44367859867467;199.79754777821736;205.81689437874647;178.9528560270087;203.14514946659756;11.275722337084328;12.53846089194814;12.002453273500146;5.8519689457627635;12.844251101283351;13.608561546260978;HELO_1991;HAD superfamily hydrolase;COG0546;Phosphoglycolate phosphatase, HAD superfamily;Gph;HELO_RS05345;C;;rluC;3.1.3.18;HELO_1991;HAD superfamily hydrolase;0.3975222253876938;-0.023853638606226468;-0.1819762898014723;0.38544753103761575;-0.012074694350078019
HELO_1992;196.83983935580787;144.85028274903323;120.89350921910345;149.15882293240256;107.6284212335746;108.53666106226036;6.120872494107149;0.8889307302397913;10.3854437908828;20.305221377967875;5.399514403670108;10.7005317172043;HELO_1992;peptidase S49 family protein;COG0616;Periplasmic serine protease, ClpP class;SppA;HELO_RS05350;O;;;3.4.21.-;HELO_1992;peptidase S49 family protein;0.43984479030164625;0.15420749569022352;-0.012012194186832303;0.8529191640094407;0.41307437370779443
HELO_1993;51.835331866670096;40.10231703518361;68.4098873735157;71.77275609521092;68.50788965914042;69.8144084375427;6.511304440188309;2.976464690736031;4.555862836572823;4.357833334516183;4.690385705174414;5.997351764591567;yceF;Maf family protein YceF;COG0424;7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily;Maf;HELO_RS05355;Q;yceF; Maf family protein YceF;;yceF;Maf family protein YceF;0.3622832821671169;-0.028901743868023466;-0.02686618818980513;-0.4225399253583726;-0.7848232075254895
HELO_1994;985.2295777521264;1135.748105767195;474.2785352748467;617.4442782994944;385.97791789846025;473.7527351377219;27.32487058461336;76.66941125632836;42.876097079925614;30.33706766341135;37.05825342255858;64.07868149034535;HELO_1994;DUF177 domain protein;COG1399;23S rRNA accumulation protein YceD (essential in plants, uncharacterized in bacteria);YceD;HELO_RS05360;J;;yceF;;HELO_1994;DUF177 domain protein;-0.20491717394519782;0.0015969354934011193;-0.29492506774627714;1.0547472089458712;1.259664382891069
HELO_1995;2943.42568248402;2447.4067313416494;174.38413755822754;129.49168163671476;144.86927112106127;172.6028599984153;145.62845585092472;96.42983556797056;39.660184501743544;16.52996600868254;38.953310546931135;63.00598919079755;rpmF;50S ribosomal protein L32;COG0333;Ribosomal protein L32;RpmF;HELO_RS05365;J;rpmF; 50S ribosomal protein L32;;rpmF;50S ribosomal protein L32;0.2661430206312527;0.01472755510668744;-0.25111471892625037;4.084123639669937;3.8179806190386847
HELO_1996;1758.08581319708;1382.8468896142947;995.4187653222508;1009.7818531284338;904.4373188862555;992.415786361772;87.8795435165738;93.6586083850458;36.97135690036863;78.39263174320503;46.956353170483695;72.93933661661472;plsX;phosphate acyltransferase;COG0416;Acyl-ACP:phosphate acyltransferase (fatty acid/phospholipid biosynthesis);PlsX;HELO_RS05370;I;plsX; phosphate acyltransferase;2.3.1.274;plsX;phosphate acyltransferase;0.34614153289148497;0.004354518961999787;-0.1337829022736443;0.8243562853595545;0.47821475246806955
HELO_1997;699.2133879703218;582.7069804444817;717.2662912290912;676.9628104345438;609.1216931791574;691.2495455900074;30.75426798370347;11.909984078845861;60.15365432908384;14.572731424845356;61.532164246351265;50.19243917395743;fabD;(acyl-carrier-protein) S-malonyltransferase FabD;COG0331;Malonyl CoA-acyl carrier protein transacylase;FabD;HELO_RS05375;I;fabD; (acyl-carrier-protein) S-malonyltransferase FabD;2.3.1.39;fabD;(acyl-carrier-protein) S-malonyltransferase FabD;0.262550324885261;0.05322660878853469;-0.1821951742466279;0.016502444562124907;-0.24604788032313607
HELO_1998;952.7970253647223;1017.7652661125852;751.6286699957637;677.3039896172274;633.1516324884104;687.4521986015183;26.819208060964648;36.682507262581105;18.45852581315354;52.31971231405113;23.83441104831919;42.502781268103284;fabG;3-oxoacyl-(acyl-carrier-protein) reductase FabG;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS05380;I;fabG; 3-oxoacyl-(acyl-carrier-protein) reductase FabG;1.1.1.100;fabG;3-oxoacyl-(acyl-carrier-protein) reductase FabG;-0.09506748969481471;0.12858176025945767;-0.11852864144657893;0.4703257963734888;0.5653932860683035
HELO_1999;13778.489777557535;11388.859498267318;7824.934046182195;5162.326303651232;5219.449691991142;5811.323852976678;2178.410844662434;1940.093492977204;928.7109077320184;1338.022388567189;479.9312718021462;473.5715942136606;acpP;acyl carrier protein;COG0236;Acyl carrier protein;AcpP;HELO_RS05385;I;acpP; acyl carrier protein;;acpP;acyl carrier protein;0.2747725188683994;0.42914786206942246;-0.15494100319102877;1.245335474510032;0.9705629556416326
HELO_2000;461.4802681789935;378.37669092782676;496.34432047543805;524.5237805824678;524.5647429216417;534.8325913743689;10.423140038472253;7.779480388919543;39.003883775185365;36.08279449671034;22.60177086957158;8.47330132881065;fabF;3-oxoacyl-(acyl-carrier-protein) synthase FabF;COG0304;3-oxoacyl-(acyl-carrier-protein) synthase;FabB;HELO_RS05390;IQ;fabF; 3-oxoacyl-(acyl-carrier-protein) synthase FabF;2.3.1.179;fabF;3-oxoacyl-(acyl-carrier-protein) synthase FabF;0.2857607723959372;-0.10753733246057706;-0.0279138371471106;-0.21239051999867975;-0.498151292394617
HELO_2001;404.2983561267092;405.4303789271585;338.5731907999298;360.1380687746221;349.8915643767;356.9382550458961;7.209989130630538;14.626462000849939;13.12182280822872;23.41524063593176;7.387457791570046;18.604171966472208;HELO_2001;aminotransferase domain protein;COG0115;Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase;IlvE;HELO_RS05395;EH;;fabF;4.1.3.38;HELO_2001;aminotransferase domain protein;-0.004023917519768716;-0.07598817856610118;-0.028685476631972406;0.1792735822668874;0.1832974997866561
HELO_2002;157.67535497201254;189.89247242167167;142.3684196390426;137.74829006322855;132.52988899833537;150.37800824935002;3.6593161740197657;3.9159742806678706;2.952879510384655;6.296647724689632;3.536299619997189;6.972911771304097;HELO_2002;UPF0755 family protein;COG1559;Endolytic transglycosylase MltG, terminates peptidoglycan polymerization;MltG;HELO_RS05400;M;;;;HELO_2002;UPF0755 family protein;-0.2666821431256423;-0.07842835949621474;-0.1809929227344398;0.06792244000646352;0.33460458313210584
HELO_2003;191.84532710438086;175.44518659488713;122.31038385578161;125.66410140407277;134.16972149058378;126.736912536362;3.2808140544814686;1.0814532266171515;1.8106850917595867;5.267109033129781;6.120671298138487;14.851176380357;tmk;thymidylate kinase;COG0125;Thymidylate kinase;Tmk;HELO_RS05405;F;tmk; thymidylate kinase;2.7.4.9;tmk;thymidylate kinase;0.1282241139002771;-0.0508811925013708;0.08159653347111906;0.5942687025932702;0.46604458869299314
HELO_2004;150.57371889084519;150.34702306799556;125.15321618231246;124.22740405633863;115.2214351477317;127.89316437351535;10.651290093923143;2.71013584933075;4.204791478585048;8.484193032509744;1.8179016748703742;9.739573927128916;holB;DNA polymerase 3 delta' subunit;COG0470;DNA polymerase III, delta prime subunit;HolB;HELO_RS05410;L;holB; DNA polymerase 3 delta' subunit;2.7.7.7;holB;DNA polymerase 3 delta' subunit;0.0021593305123719375;-0.030998767668207527;-0.1492995800395942;0.23384387386781125;0.2316845433554393
HELO_2005;172.6116596050641;203.61755499425453;186.24966268151923;237.77110953924736;188.10493391649916;190.41626279398182;4.719850538843493;2.151722986128487;14.130482649919172;10.406302228923481;11.452796360201258;15.124082807999242;ycfH;TatD-type hydrolase YcfH;COG0084;3'->5' ssDNA/RNA exonuclease TatD;TatD;HELO_RS05415;N;ycfH; TatD-type hydrolase YcfH;3.1.21.-;ycfH;TatD-type hydrolase YcfH;-0.23706608406813512;-0.03175028715445549;-0.017526401936588165;-0.14084956576118923;0.09621651830694589
HELO_2006;118.53431214381762;144.7433628504833;123.86199107871101;136.56677202223887;109.7895720176942;114.64834517260404;5.353178331987756;6.648143952131329;8.29374919565715;5.519785112895268;6.873776085024458;3.131008430186037;HELO_2006;UvrD/REP-type helicase;COG0210;Superfamily I DNA or RNA helicase;UvrD;HELO_RS05425;L;;ycfH;3.6.4.12;HELO_2006;UvrD/REP-type helicase;-0.2860053835341727;0.11058975423677264;-0.06192252717989444;0.04768017867880481;0.3336855622129775
HELO_2007;148.0962260264602;132.86712071930887;141.48681709011328;161.23748988468967;177.7000437412415;141.64953342311014;9.029354097219118;3.8379862486458367;8.153948421658049;4.642670583340564;7.3084203301216135;5.565960110802042;HELO_2007;rhodanese domain protein;COG2897;3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains;SseA;HELO_RS05430;P;;;2.8.1.1,2.8.1.2;HELO_2007;rhodanese domain protein;0.15544207817217437;-0.0016465811654393647;0.3250649593420407;0.06376871193154088;-0.09167336624063349
HELO_2008;187.07560016243295;92.30619888812919;193.47927624097306;204.17416609861974;153.82488577075887;189.71686114458421;10.763219545084956;1.8718690367268633;4.664928032392654;5.392708598339028;8.644483004155227;1.0472033973615191;HELO_2008;MipA family protein;COG3713;Outer membrane scaffolding protein for murein synthesis, MipA/OmpV family;OmpV;HELO_RS05435;M;;;;HELO_2008;MipA family protein;1.0112678578910153;0.028184032516184843;-0.30079501531020103;-0.02011970283709985;-1.031387560728115
HELO_2009;111.45935365231624;129.54999161030906;8.46897737266333;10.83073819615715;7.883456055474718;9.651007122385884;10.440346591123438;8.324351313184486;2.9209588713631462;0.3248133728058296;1.5306459321825732;3.9939807951693447;HELO_2009;uncharacterized protein;;;;;;;;;HELO_2009;uncharacterized protein;-0.2151987046519448;-0.16970932161295993;-0.2617968903754746;3.400341902019484;3.615540606671429
HELO_2010;63.07971385717531;66.15225977004305;39.043002753432184;34.50046559417536;21.63366718295498;21.454392313945522;5.378081913249125;13.428497901741979;8.704924832450008;17.11030584635202;4.893899763235241;2.3394719876404353;HELO_2010;WGR domain protein;;;;;;;;;HELO_2010;WGR domain protein;-0.06756824370900016;0.8345524845533507;0.011472675043084912;1.5128700267142259;1.580438270423226
HELO_2011;152.06777382988523;94.35018826474577;170.8758880423351;224.06002211476752;200.0461334037102;166.4018530438071;3.6226955041215936;6.695539272159858;15.972950467283615;6.991276330579779;4.594850611467148;2.4303403748357133;pdxB;erythronate-4-phosphate dehydrogenase;COG0111;Phosphoglycerate dehydrogenase or related dehydrogenase;SerA;HELO_RS05445;H;pdxB; erythronate-4-phosphate dehydrogenase;1.1.1.290;pdxB;erythronate-4-phosphate dehydrogenase;0.6828628843784417;0.03805166981570718;0.26421109214658056;-0.1291449212248379;-0.8120078056032796
HELO_2012;443.630551102533;86.69314332789266;201.17290694145524;225.0187549388213;207.36280016716736;220.0532194358224;20.75153875080791;2.008877805067376;9.386281687978768;0.49414574434925607;13.733963129111608;2.869995632095442;htpX;protease HtpX;COG0501;Zn-dependent protease with chaperone function;HtpX;HELO_RS05450;O;htpX; protease HtpX;3.4.24.-;htpX;protease HtpX;2.3420711323223316;-0.12880407038607355;-0.08529601539656273;1.0082133351257818;-1.3338577971965497
HELO_2013;99.42155131545003;72.90484307201348;126.93805017860932;112.38467564940028;135.66339080478795;134.3819751360604;5.893403151280495;6.070318360373822;7.787319429929928;5.394921997160992;10.959154812821671;10.665234738731808;alaA;alanine aminotransferase;COG0436;Aspartate/methionine/tyrosine aminotransferase;AspB;HELO_RS05455;E;alaA; alanine aminotransferase;2.6.1.66,2.6.1.2;alaA;alanine aminotransferase;0.4423281029924322;-0.0815902687744563;0.013591157464871273;-0.43096675304120424;-0.8732948560336364
HELO_2014;203.31338003125833;163.38941005469295;229.6018617603604;215.75229993498328;202.62339798486252;236.7336415736929;5.275430736094194;6.356937323027896;17.920154755691815;6.787773814729232;8.329095797543662;4.365475457459395;rbgA;ribosome biogenesis GTPase RbgA;COG1161;Ribosome biogenesis GTPase RbgA;RbgA;HELO_RS05460;J;rbgA; ribosome biogenesis GTPase RbgA;;rbgA;ribosome biogenesis GTPase RbgA;0.3136663222931766;-0.043941912198998345;-0.22344272447537872;-0.21856238673907047;-0.5322287090322471
HELO_2015;146.0911417180362;112.63386367036598;290.57441549021974;170.9289223266854;236.7826666064384;263.3024023536588;2.35291608147449;9.558059220584118;30.555576568403495;24.087987894772265;29.50101283293162;28.645628167558886;msrB1;peptide methionine sulfoxide reductase MsrB (R-form specific);COG0229;Peptide methionine sulfoxide reductase MsrB;MsrB;HELO_RS05465;O;msrB1; peptide methionine sulfoxide reductase MsrB (R-form specific);1.8.4.12;msrB1;peptide methionine sulfoxide reductase MsrB (R-form specific);0.37231753373727017;0.14167459610493793;-0.15254598600015878;-0.8454791726236044;-1.2177967063608746
HELO_2016;106.24985747366843;116.79097046944531;80.43362460547884;171.296724967259;73.27860069592424;82.36293203935257;10.141183159955347;4.569687643423944;11.509597716336026;7.80160966675044;3.6673272550214517;9.298354744083573;yadG;ABC-type transport system ATP-binding protein YadG;COG1131;ABC-type multidrug transport system, ATPase component;CcmA;HELO_RS05500;V;yadG; ABC-type transport system ATP-binding protein YadG;;yadG;ABC-type transport system ATP-binding protein YadG;-0.13525321988692873;-0.033781402930923576;-0.1664593837599595;0.36349780443969326;0.498751024326622
HELO_2017;95.72659840944554;132.61686330313668;47.68532448403689;97.31202123580421;38.868557228659114;51.54234208403917;11.908999624300217;7.885504024988041;3.7096427709910063;5.935313980470567;3.344386140021946;2.0677167044286673;yadH;ABC-type transport system permease protein YadH;COG0842;ABC-type multidrug transport system, permease component;YadH;HELO_RS05505;V;yadH; ABC-type transport system permease protein YadH;;yadH;ABC-type transport system permease protein YadH;-0.4661175270987119;-0.10999355286323631;-0.39822911254474835;0.8804321541496263;1.3465496812483382
HELO_2018;149.85554590631423;174.58350661738896;89.98263489391748;190.3346702318023;73.4119789352036;93.86021923720456;17.53929940697588;6.765775752444179;5.6293255598944345;10.690498277363979;2.6529644694025656;9.62091964864637;queF;7-cyano-7-deazaguanine reductase;COG2904;NADPH-dependent 7-cyano-7-deazaguanine reductase QueF, N-terminal domain;QueFN;HELO_RS05510;J;queF; 7-cyano-7-deazaguanine reductase;1.7.1.13;queF;7-cyano-7-deazaguanine reductase;-0.21898959682910757;-0.060211986454614674;-0.35026831580593676;0.669292627460532;0.8882822242896395
HELO_2019;288.435971751601;218.87534010315917;267.71641894342923;350.36944208081167;227.13849506191445;253.23322294611864;15.566173428893041;17.968642747575434;23.608803632018898;37.54420580697325;19.20032431196516;16.910948764187427;ydjA;nitroreductase family protein YdjA;COG0778;Nitroreductase;NfnB;HELO_RS05515;C;ydjA; nitroreductase family protein YdjA;;ydjA;nitroreductase family protein YdjA;0.39655842512779227;0.07993190207555667;-0.15624267157108473;0.1870916617639251;-0.20946676336386716
HELO_2020;27.18076401753795;18.529708100488364;22.562768240555794;28.22632276856719;23.642731338705;19.909638045872757;0.6606298819228666;1.894615229484847;2.3416438573893155;3.713692257963793;3.3264782284044196;4.099080426074819;zitB;cation diffusion facilitator family transport protein (probable substrate zinc);COG1230;Co/Zn/Cd efflux system component;CzcD;HELO_RS05530;P;zitB; cation diffusion facilitator family transport protein (probable substrate zinc);;zitB;cation diffusion facilitator family transport protein (probable substrate zinc);0.5290403392975431;0.1723409537174021;0.23699408108472397;0.4305426370154999;-0.09849770228204324
HELO_2021;37.3283762646968;56.1666037628169;34.54655306669926;32.23778491347047;19.927717970358074;32.811435141961475;0.44144742204524345;2.248990514873618;2.520078088524625;0.28652242685160423;2.766209886304405;1.621754511330543;ybiT;ABC-type transport system ATP-binding protein YbiT;COG0488;ATPase components of ABC transporters with duplicated ATPase domains;Uup;HELO_RS05535;R;ybiT; ABC-type transport system ATP-binding protein YbiT;;ybiT;ABC-type transport system ATP-binding protein YbiT;-0.5767597016786219;0.07219841574895902;-0.6920962495979825;0.18090162801505727;0.7576613296936792
HELO_2022;8.73869931878229;8.0170687866661;6.161477523381913;5.163590558690616;5.16715879888842;6.339621462408783;0.3628132612583869;0.1808855067960655;0.9766049152335943;0.24478821292831685;0.9673500501913472;0.5126395437525104;umuC1;DNA polymerase 5 complex protein UmuC;COG0389;Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair;DinP;HELO_RS05540;L;umuC1; DNA polymerase 5 complex protein UmuC;;umuC1;DNA polymerase 5 complex protein UmuC;0.11107057445836643;-0.035448390195984114;-0.2510996637395011;0.40802344305139515;0.2969528685930287
HELO_2023;5.498182648648325;5.906195652482644;6.660054576744126;7.439687246786073;4.968906784808337;5.315953122691933;0.8149786884181486;0.3102198671264069;0.6579845109945605;1.502295433271508;0.9890336029553561;1.6741501243069914;umuD1;DNA polymerase 5 associated protein UmuD;COG1974;SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase);LexA;HELO_RS05545;KT;umuD1; DNA polymerase 5 associated protein UmuD;3.4.21.-;umuD1;DNA polymerase 5 associated protein UmuD;-0.08785491130673595;0.27835420768756247;-0.08153373979444067;0.041035831519776966;0.12889074282651292
HELO_2024;486.30045408986933;115.97531787463548;811.2127260411656;990.8350102447079;769.8866931199977;729.6562917099089;10.15705571040973;2.895588564619895;46.03816816171488;51.562736487312755;137.14626868110417;88.8770037350394;HELO_2024;glutamate carboxypeptidase;COG0624;Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase;ArgE;HELO_RS05550;E;;umuD1;3.4.17.11;HELO_2024;glutamate carboxypeptidase;2.05860741774719;0.15266472504776907;0.07732591769255492;-0.5843813401533424;-2.6429887579005324
HELO_2025;6.932900085467843;9.586696273752613;9.7618853391501;5.751144716093229;13.262768791776809;9.092331980054915;1.3599192548601358;0.9931136607632137;1.439037351118405;0.7033133039349183;0.9773688076160673;1.7700027195798385;HELO_2025;ChrA family transport protein;COG2059;Chromate transport protein ChrA;ChrA;HELO_RS05555;P;;;;HELO_2025;ChrA family transport protein;-0.4163321629185508;0.0926712723843579;0.49899450672876;-0.3473392850978434;0.0689928778207074
HELO_2026;4.149710862347551;5.859456096808084;4.90206364191773;4.360855627267674;6.83105216210124;5.2743504965096095;0.7941463342542752;0.6212233135415977;0.7745682685894616;0.34054964003161264;0.42835176553470233;1.3353802127239096;HELO_2026;ChrA family transport protein;COG2059;Chromate transport protein ChrA;ChrA;HELO_RS05560;P;;;;HELO_2026;ChrA family transport protein;-0.41360275362764165;-0.08824664554776795;0.3197400347426993;-0.28497469051623936;0.1286280631114023
HELO_2027;9.620760646539983;13.001151200629655;23.072518937534984;16.202558168698364;31.434898077495603;25.04613822767101;1.1302334148339321;1.1015146041050805;2.311417239542569;1.2773097513381662;2.7653044891967817;4.436040628910769;HELO_2027;homolog to gamma-glutamyltranspeptidase;COG0405;Gamma-glutamyltranspeptidase;Ggt;HELO_RS05565;E;;;2.3.2.2,3.4.19.13;HELO_2027;homolog to gamma-glutamyltranspeptidase;-0.3986583591250361;-0.1136823722023177;0.31647742046673066;-1.2941823908874985;-0.8955240317624624
HELO_2028;61.56075602369748;59.4024287695697;62.93302018041205;76.02074342770693;77.3295014032443;63.75725839905709;3.273337768311302;2.7715382715477204;2.424604458950707;1.6113730615499546;5.610935044538628;2.288350513365985;HELO_2028;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS05570;K;;;;HELO_2028;GntR family transcription regulator;0.05065138599340102;-0.018480660140894223;0.27451386694693625;-0.04978396096842719;-0.10043534696182821
HELO_2029;23.221309966072255;2.0716358363172387;13.025210319469295;21.527103934052647;24.963280962558283;13.946803333553293;2.6743103826439376;0.6028165830771322;2.282380644036188;0.8205510864118272;4.732848899253768;1.5349019197074316;HELO_2029;STAS domain protein;;;;;;;;;HELO_2029;STAS domain protein;2.9791978028838324;-0.09181456345563754;0.7966357384298912;0.6964399238730183;-2.282757879010814
HELO_2030;5.942963981259452;4.065691918258121;7.193227019746412;8.55268305782049;6.039744448334672;7.514009292897953;0.4190594138256206;0.2777003884863027;0.6592112275004477;0.8863442016425561;0.3961924205482466;0.2097833467533657;yciC;CobW domain protein YciC;COG0523;Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family;YejR;HELO_RS05580;R;yciC; CobW domain protein YciC;;yciC;CobW domain protein YciC;0.45479234814719094;-0.05540687490639318;-0.2743156066472143;-0.2942869777598611;-0.7490793259070521
HELO_2031;9.017836240680497;5.547420635393773;7.86071714165788;8.66807661209027;6.784027558129734;8.00147681269567;0.31875846008058034;0.55193474601193;0.640972180739498;0.8024033051340923;0.5298704304309843;0.6855480291572514;folE2;GTP cyclohydrolase FolE2;COG1469;GTP cyclohydrolase FolE2;FolE2;HELO_RS05585;H;folE2; GTP cyclohydrolase FolE2;3.5.4.16;folE2;GTP cyclohydrolase FolE2;0.6135723613331296;-0.02273824633303345;-0.20964489651930363;0.15433731409361817;-0.4592350472395115
HELO_2032;74.82474338496029;12.291653559209147;85.0942058125569;141.86232342221754;104.34405163696347;67.6819732449254;0.917904154355353;0.9511979499831558;17.763989410708923;22.643912370904534;16.692311233059307;1.8517011088628186;HELO_2032;glyoxalase domain protein;COG3607;Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family;;HELO_RS05590;R;;folE2;;HELO_2032;glyoxalase domain protein;2.51214811486408;0.32598465790623266;0.6171054592320306;0.14273722150641266;-2.369410893357667
HELO_2033;8.560013254716933;7.199135436196592;16.41679135711858;14.073133847570437;14.030721217644391;17.51333981934162;0.14692824303573937;0.6982289734542728;1.652208489228012;0.8356366191263807;1.4893008414945395;0.4698388011848619;HELO_2033;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS05595;G;;;;HELO_2033;TRAP transporter large transmembrane protein;0.22154082674555253;-0.0880863168081012;-0.30065094626103317;-0.9534806582926776;-1.1750214850382301
HELO_2034;8.517504538593698;6.615646324019181;7.307280595964947;6.420238098756077;6.490313726687134;8.911129244100712;0.8495610865899631;0.5455043610105993;0.6668130208417071;1.2910001312815536;1.5824199748036352;1.2390148427503953;HELO_2034;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS05600;G;;;;HELO_2034;TRAP transporter small transmembrane protein;0.3216168723354218;-0.25467315776377664;-0.4040232968394837;-0.058466090324999165;-0.38008296266042096
HELO_2035;13.337937706401277;10.721316680750954;27.469376677783377;25.069182610614007;24.919672357011308;28.32271684940544;1.5194340482862696;0.9663737284419895;2.3303387600464345;2.876603711933791;1.1079006685705288;2.603120583151842;HELO_2035;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS05605;G;;;;HELO_2035;TRAP transporter substrate-binding protein;0.2907028893853938;-0.042607873897622106;-0.17797129861271443;-1.032181250974801;-1.3228841403601947
HELO_2036;16.835165791141605;12.757210407535764;18.02391426508366;12.627530782514297;12.178929331143964;21.209766061670326;1.1544250628941781;0.7900224817673364;1.5746847817834007;0.9957507284606681;0.1423977760785116;0.8157515295278924;HELO_2036;HAE1 family transport protein;COG0841;Multidrug efflux pump subunit AcrB;AcrB;HELO_RS05610;V;;;;HELO_2036;HAE1 family transport protein;0.37453666686905596;-0.22338007844293184;-0.7529610276938796;-0.31646957008070586;-0.6910062369497618
HELO_2037;11.554938604184676;11.513672386626617;17.042976471872915;15.996700564838562;11.625404307946217;19.560887803389196;1.0300141427035003;1.199219601280457;0.770746824332036;0.32093559466779814;0.6757184705025359;2.591380033305664;HELO_2037;RND family transport protein MFP component;COG0845;Multidrug efflux pump subunit AcrA (membrane-fusion protein);AcrA;HELO_RS05615;VM;;;;HELO_2037;RND family transport protein MFP component;0.0047497343369928835;-0.18846520695012448;-0.7035729717878794;-0.7116475867446805;-0.7163973210816734
HELO_2038;142.2715435125914;126.04353751520382;113.53770498957037;112.55459391535187;88.98302048863866;110.93006787510217;3.552268599119756;2.763952105170075;5.947240335399379;1.9678470405718338;4.649796212968785;1.0761522961256553;yhiN;YhiN family protein;COG2081;Predicted flavoprotein YhiN;YhiN;HELO_RS05620;R;yhiN; YhiN family protein;;yhiN;YhiN family protein;0.17342910117837462;0.03322496050435486;-0.3148729406029407;0.35615445018904524;0.1827253490106706
HELO_2039;55.75024187533057;58.007645967230665;48.14622687068652;60.77223294807225;46.55225221501208;43.02148109861165;3.2544425313634346;2.5874495358940997;1.2984138240536285;1.3570653276813922;2.535016021905844;2.3657861530674964;HELO_2039;CHAD domain protein;COG5607;CHAD domain, binds inorganic polyphosphates;CHAD;HELO_RS05625;S;;yhiN;;HELO_2039;CHAD domain protein;-0.056275363725694305;0.15887297464099515;0.11130598761353294;0.3664188559446897;0.422694219670384
HELO_2040;154.11438506197788;82.32076003511055;164.50013800717284;200.36832969650695;188.1354659851689;172.02102096534227;3.4384792687139636;5.107195862843503;13.745239573877413;5.2352564393001355;7.457744965198768;0.47579276664074266;HELO_2040;ParA domain protein;COG1192;ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ;ParA;HELO_RS05630;DN;;;;HELO_2040;ParA domain protein;0.8965845813040865;-0.06411490681321119;0.12847259062941863;-0.15761484105253398;-1.0541994223566205
HELO_2041;619.2703169479565;153.78949455060328;135.4532123751037;193.02077384139594;149.68954555324504;138.08261771336373;30.50449204159385;9.491129981048923;22.806809095518894;16.38712005807724;8.116621774494627;26.27139391287152;HELO_2041;YqjK family protein;;;;;;;;;HELO_2041;YqjK family protein;2.002589526201894;-0.02753576693533244;0.11563720419104051;2.1569549605471847;0.1543654343452907
HELO_2042;1078.836477482343;226.56701210301568;161.60291136638293;166.14547543059746;153.81947588595096;184.78257776086699;37.30743587431736;33.90538046796389;30.53115054023067;25.669481100022516;7.710368453455089;41.04279640435958;HELO_2042;DUF1469 domain protein;COG5393;Uncharacterized membrane protein YqjE;YqjE;HELO_RS05640;S;;;;HELO_2042;DUF1469 domain protein;2.2464495115546885;-0.19226212687011301;-0.26302824545628667;2.539125737033385;0.2926762254786963
HELO_2043;781.2386977701434;149.78542986593493;411.8544002901006;366.6661902381054;360.177413174667;358.19355982087563;33.6755133207675;18.074964566495886;70.83670182508844;68.35476710951599;42.877979436647074;64.59187251985657;HELO_2043;DUF883 domain protein;COG4575;Membrane-anchored ribosome-binding protein ElaB, inhibits growth in stationary phase, YqjD/DUF883 family;ElaB;HELO_RS05645;J;;;;HELO_2043;DUF883 domain protein;2.3751118785112544;0.2008715984136984;0.007946190888326043;1.1228474253006961;-1.2522644532105582
HELO_2044;195.23829926106703;61.169119507557355;100.84587831460908;94.2107361736373;73.69783394454616;102.37746955186515;7.380044139118974;1.9238862643044603;2.316879051953247;3.187481604160586;3.605875007283692;7.699005568949341;pldA;phospholipase A1;COG2829;Outer membrane phospholipase A;PldA;HELO_RS05650;M;pldA; phospholipase A1;3.1.1.32,3.1.1.4;pldA;phospholipase A1;1.6583365842068414;-0.02153419803439416;-0.4687834798090105;0.9246848417573936;-0.7336517424494478
HELO_2045;77.41036926343737;30.97789303415684;45.17069608330132;49.081569002481324;46.7149036873107;45.74492680649249;1.4696945264265489;0.3867182093932439;1.7388100906321784;1.2091616767022524;1.878196426510465;0.46536496228367885;mscK;mechanosensitive ion channel MscK;COG3264;Small-conductance mechanosensitive channel MscK;MscK;HELO_RS05655;M;mscK; mechanosensitive ion channel MscK;;mscK;mechanosensitive ion channel MscK;1.2939695686621207;-0.017832315778523622;0.029630161682726808;0.746234655196842;-0.5477349134652787
HELO_2046;37.07960816304911;42.85172638629307;144.00916822617623;143.44387424477068;41.61661782274415;102.18173355795504;2.8187677006404708;5.5926267759767185;20.30245043785038;18.91267372602871;20.1079897170328;58.298619721245345;HELO_2046;RND family transport protein MFP component;COG1566;Multidrug resistance efflux pump EmrA;EmrA;HELO_RS05665;V;;mscK;;HELO_2046;RND family transport protein MFP component;-0.20361500736943405;0.49095652718258354;-1.2756995841971461;-1.4380970519623908;-1.2344820445929567
HELO_2047;42.36873129071684;27.160479597929594;138.1196189516085;104.82910118376185;48.86618014356875;101.82957901123099;1.9278980409921957;1.839588668801836;11.743575857625473;9.580302035177887;19.557567589202048;58.09989151252578;HELO_2047;HlyB family toxin translocation ATP-binding protein;COG2274;ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain;SunT;HELO_RS05670;V;;;;HELO_2047;HlyB family toxin translocation ATP-binding protein;0.6229833346438785;0.43607056960309265;-1.0441217178087605;-1.2455281723039402;-1.8685115069478186
HELO_2048;122.73057846199178;53.261161687355035;73.7353469158435;108.27799271105168;102.38651209204225;75.51631766985436;4.674768186667258;3.684401187070041;3.1260587536279467;4.429912824068891;4.9608176616288775;1.774081645331813;HELO_2048;toxin TlyA family protein;COG1189;Predicted rRNA methylase YqxC, contains S4 and FtsJ domains;YqxC;HELO_RS05675;J;;;2.1.1.226,2.1.1.227;HELO_2048;toxin TlyA family protein;1.1892102483891893;-0.033976702853249385;0.4342086313875537;0.6933627372790525;-0.4958475111101368
HELO_2049;60.22500404491647;30.295578577057466;44.08007016922965;47.18074020769128;37.66857206393126;38.5812579161553;7.1424793505080855;2.2094274414308623;2.8965821596061305;5.56136155616334;4.640857334145408;9.911505059520195;HELO_2049;AbrB family protein;COG3180;Uncharacterized membrane protein AbrB, regulator of aidB expression;AbrB;HELO_RS05680;R;;;;HELO_2049;AbrB family protein;0.9681621157477958;0.18767229830481735;-0.03365597263444631;0.6293035012738288;-0.3388586144739669
HELO_2050;228.21329276125502;62.618996970432185;159.89676926028514;188.9523730372696;171.14594955886614;168.2744447570859;9.686352926595495;1.0192292989211282;11.529124263796795;4.829079036366604;14.168505812252658;4.0135310467027745;HELO_2050;uncharacterized protein;;;;;;;;;HELO_2050;uncharacterized protein;1.8491611813447495;-0.07322882938493525;0.024268048950434107;0.43732652567634833;-1.4118346556684012
HELO_2051;43.12361572522648;20.604531347084446;64.21255911688696;105.93706249995707;100.38250540287372;65.32441846005331;2.7943580452952874;1.801286895526148;9.390262224142969;2.683889184795041;9.191347676186389;2.7915190670478376;HELO_2051;uncharacterized protein;;;;;;;;;HELO_2051;uncharacterized protein;1.030217082095878;-0.024390284703029508;0.6121966959968672;-0.5879891028708162;-1.6182061849666942
HELO_2052;201.90700604250358;84.18642818331146;88.01618911805194;97.18500702858826;89.6309400860279;74.33617665972712;3.0208662971310627;1.80084800830974;8.007772210765669;11.99381544429489;13.089638512045436;4.672884757413034;HELO_2052;DUF533 domain protein;COG2979;Uncharacterized membrane protein YebE, DUF533 family;YebE;HELO_RS05700;S;;;;HELO_2052;DUF533 domain protein;1.2521231746844883;0.2407249209261897;0.26666083167462595;1.429403956901174;0.17728078221668575
HELO_2053;210.68809301016174;89.17802682788401;138.4053265665981;128.60172487213558;153.32015079835705;131.9699759291319;7.588088250666067;5.036074426271806;4.3638392374328125;1.2199369608591761;5.736106502978708;3.181313893975569;aphA;acetylpolyamine aminohydrolase;COG0123;Acetoin utilization deacetylase AcuC or a related deacetylase;AcuC;HELO_RS05705;Q;aphA; acetylpolyamine aminohydrolase;;aphA;acetylpolyamine aminohydrolase;1.2310922751674838;0.0681851585671911;0.21482593034933561;0.6708395952815192;-0.5602526798859646
HELO_2054;34.79188320484092;13.202166220593881;32.49795865558007;38.77862741504028;31.650090822616875;30.628616540302712;1.0361986246876502;1.022052537917355;3.244655350059583;3.367734419869532;4.61410451417619;2.2932596531867837;HELO_2054;NCKX family transport protein;COG0530;Ca2+/Na+ antiporter;ECM27;HELO_RS05710;P;;aphA;;HELO_2054;NCKX family transport protein;1.3335214566022753;0.08284272866639242;0.04585655225673868;0.17840200109261772;-1.1551194555096576
HELO_2055;353.2922811029877;333.49912464914564;339.9827527712193;420.28973785666267;351.6446450170743;342.8416807803258;13.726859789717409;10.901259721012458;7.15257375283452;15.015918171777601;10.700969301812798;11.011192117910722;dnaX;DNA polymerase 3 tau subunit;COG2812;DNA polymerase III, gamma/tau subunits;DnaX;HELO_RS05715;L;dnaX; DNA polymerase 3 tau subunit;2.7.7.7;dnaX;DNA polymerase 3 tau subunit;0.08293759859978067;-0.012045671912813916;0.036470692117740455;0.04319559394860839;-0.03974200465117228
HELO_2056;468.1608555596815;394.2141913272744;453.9213784054252;437.82253700538195;405.0804908083605;346.90059167670955;18.3803325644038;23.80114169206415;53.4158826424753;105.79602438029308;30.970914144555966;27.090996026695215;ybaB;nucleoid-associated protein YbaB;COG0718;DNA-binding nucleoid-associated protein YbaB/EfbC;YbaB;HELO_RS05720;K;ybaB; nucleoid-associated protein YbaB;;ybaB;nucleoid-associated protein YbaB;0.2474478950547052;0.3869421011344478;0.22309058544278493;0.4314075145533067;0.1839596194986015
HELO_2057;374.4670672572807;308.08577489662065;291.94295888090596;315.9381848019695;293.9893554548158;293.7712309195176;27.90586005888628;24.508302897779224;4.459284064836206;7.826703270176436;11.752116845625679;10.864487653618927;recR;recombination protein RecR;COG0353;Recombinational DNA repair protein RecR;RecR;HELO_RS05725;L;recR; recombination protein RecR;;recR;recombination protein RecR;0.2806791141421261;-0.008975953133809611;0.0010671693123960324;0.3490906453212812;0.0684115311791551
HELO_2058;268.3665799200124;220.37945755245337;192.3776905980485;222.08099194825573;186.75176130298124;176.896123338214;7.5489304069757495;1.9889187441920666;12.392779167527332;17.903603999891132;16.955806882436757;3.6275601833308317;rnd;ribonuclease D;COG0349;Ribonuclease D;Rnd;HELO_RS05730;J;rnd; ribonuclease D;3.1.13.5;rnd;ribonuclease D;0.28304951153312974;0.12038629288444813;0.07779136960659638;0.5985357958226114;0.31548628428948167
HELO_2059;196.5269918635253;150.5031782764813;88.51712805682065;109.9994823190105;87.82726624966189;87.11126111678686;16.751284136044333;10.633556904016384;5.161632541451612;5.7334377527757745;2.923358127821852;5.9851690206153165;HELO_2059;YcgL domain protein;COG3100;Uncharacterized conserved protein YcgL, UPF0745 family;YcgL;HELO_RS05735;S;;rnd;;HELO_2059;YcgL domain protein;0.3827017502979775;0.022837336129908792;0.011676175995053661;1.1646514889618684;0.781949738663891
HELO_2060;170.6517720447258;150.8862824609312;102.70523510080842;140.35003485584227;90.79652572407217;106.51729881054428;10.08424177110293;7.549367900646877;7.7140901603378085;7.753958671637852;6.922986470898838;0.9968695196295028;HELO_2060;UPF0260 family protein;COG2983;Uncharacterized cysteine cluster protein YcgN, CxxCxxCC family;YcgN;HELO_RS05740;R;;;;HELO_2060;UPF0260 family protein;0.17649317162381273;-0.05208007434563111;-0.22805734114725063;0.6749159525917028;0.49842278096789006
HELO_2061;193.92544493810956;106.44318831862579;114.60654485766071;153.27246434783447;134.54174991780945;114.83520761295976;5.870160746847928;2.547464665619026;7.872819661788567;5.849769253667936;7.881078445820669;5.9989737517209045;modA;ABC-type transport system periplasmic substrate-binding protein (probable substrate molybdate);COG0725;ABC-type molybdate transport system, periplasmic Mo-binding protein ModA;ModA;HELO_RS05745;P;modA; ABC-type transport system periplasmic substrate-binding protein (probable substrate molybdate);;modA;ABC-type transport system periplasmic substrate-binding protein (probable substrate molybdate);0.859348405930354;-0.0028507451825188213;0.22666348173250572;0.7508486067090558;-0.10849979922129815
HELO_2062;180.2892686880733;92.34623292802331;75.76726346149378;99.3378745103319;95.80922922743271;80.10295339870373;15.691445908111318;3.1300400461437676;0.6071122776066648;5.62965130789276;0.8404488917669889;5.635783981336443;modB;ABC-type transport system permease protein (probable substrate molybdate);COG4149;ABC-type molybdate transport system, permease component ModB;ModB;HELO_RS05750;P;modB; ABC-type transport system permease protein (probable substrate molybdate);;modB;ABC-type transport system permease protein (probable substrate molybdate);0.9576298206521052;-0.07926323078868336;0.255390140433839;1.1604671712546484;0.20283735060254315
HELO_2063;68.28484922447039;38.248231161631544;41.02137980640044;39.69812460890801;41.267397602643165;36.483666355049905;2.4995452786784207;0.9413896417226234;0.8226185860514542;1.095584812522193;2.887885889707807;2.2640392481056995;modC;ABC-type transport system ATP-binding protein (probable substrate molybdate);COG4148;ABC-type molybdate transport system, ATPase component ModC;ModC;HELO_RS05755;P;modC; ABC-type transport system ATP-binding protein (probable substrate molybdate);7.3.2.5;modC;ABC-type transport system ATP-binding protein (probable substrate molybdate);0.8199122712406934;0.16486146197206342;0.17328321569576488;0.8862778344743596;0.06636556323366616
HELO_2064;91.5993819642568;60.048090761395116;144.1379117780249;140.81888152930765;117.1339176351574;145.06995733317686;8.104428810591534;2.368531557650947;12.406481716871006;0.6746800731766593;11.004041377767615;7.281894829263139;HELO_2064;peptidase S9 family protein;COG1770;Protease II;PtrB;HELO_RS05760;E;;modC;3.4.21.83;HELO_2064;peptidase S9 family protein;0.6010563879566604;-0.009235067005392672;-0.3062362461326229;-0.6575850153761325;-1.2586414033327928
HELO_2065;389.82662683094367;183.9032691706603;254.20794743839892;247.21960924388563;191.24704591141312;206.09627416360254;16.347265269216656;13.49311737330884;20.955168607094016;40.0545982846144;7.945979431914859;14.227612731791288;HELO_2065;MFS domain protein;;;;;;;;;HELO_2065;MFS domain protein;1.0797580283301578;0.301371658319157;-0.10734016874127761;0.9162271622839828;-0.16353086604617495
HELO_2066;301.4321640249985;157.9345839990301;205.7138688704641;237.07459276195945;174.08829896593636;185.86616412579224;6.240757761145619;8.73064623173542;11.256489120921636;15.965421168484419;10.241077662990493;3.0088140910937904;HELO_2066;vWF-A domain protein;;;;;;;;;HELO_2066;vWF-A domain protein;0.9281784922974134;0.14562982166917937;-0.09392269115447949;0.694606216272529;-0.2335722760248844
HELO_2067;420.3061361538882;222.53166290893293;67.20733718484907;65.0519933351862;32.11230313324654;26.826894031674133;13.311501052452051;3.2787989081053306;21.796669902892607;32.39417673777218;9.38601205495098;4.487502312042417;HELO_2067;uncharacterized protein;;;;;;;;;HELO_2067;uncharacterized protein;0.9143897269547026;1.293447053231608;0.25088747354057084;3.9203171355687543;3.0059274086140517
HELO_2068;220.14233312083502;79.56910900705834;56.83219110444744;66.54445292344815;41.92540058095886;35.329613954717985;16.422940070309323;12.97101160438353;9.644526684929836;19.202987400392633;12.383669016689042;8.440957475123199;HELO_2068;DUF2493 domain protein;;;;;;;;;HELO_2068;DUF2493 domain protein;1.4566765193481954;0.6707267274614575;0.24068556207087077;2.605757285085634;1.1490807657374384
HELO_2069;10.371916130265957;1.4130571993683876;2.2592325613595308;2.5290764805899957;2.640328947438063;1.4395080785816632;0.2457642693564334;0.2289535391426137;1.0150051678163154;0.7107776840786594;1.0844723255361461;0.4789821632532383;HELO_2069;uncharacterized protein;;;;;;;;;HELO_2069;uncharacterized protein;2.236541345185723;0.4179420378861718;0.5774785602914085;2.2208131980981447;-0.01572814708757808
HELO_2070;17.261828894075112;3.4728632844736023;6.559849462192372;7.892797531475086;5.250027043750411;5.4175789161652625;0.40807334251997235;0.3952131817725533;1.6990260589044797;2.1751801404081026;0.4938359529495395;1.0928085063838102;HELO_2070;uncharacterized protein;;;;;;;;;HELO_2070;uncharacterized protein;2.0295606888852156;0.2363283750772056;-0.03816669924749094;1.50873021958397;-0.5208304693012455
HELO_2071;0.3095714554483449;0.22366344128542034;0.11905394316855038;0.0;0.0;0.0;0.26814992951531574;0.22361861272406716;0.2062074784093469;0.0;0.0;0.0;HELO_2071;NLPC domain protein;;;;;;;;;HELO_2071;NLPC domain protein;0.09788797003121402;0.16227958203907392;0.0;0.38909478103899603;0.291206811007782
HELO_2072;3.3190082622561565;2.1182500198758265;1.9829139556134414;2.6606999058071263;2.5514328994954787;2.140217257476433;0.04138489049120118;0.20927449268599727;0.07398255201136666;0.23149016242073678;0.34298126179572963;0.03219371445139629;HELO_2072;uncharacterized protein;COG4733;Phage-related protein, tail protein J;;HELO_RS05805;X;;;;HELO_2072;uncharacterized protein;0.46996346911198095;-0.07414201348168747;0.177536851271205;0.45983570028464604;-0.010127768827334904
HELO_2073;0.07790399021124483;0.1782896019310621;0.0;0.0;0.0;0.0;0.06761921366906967;0.16337986388461637;0.0;0.0;0.0;0.0;HELO_2073;NlpC domain protein;COG0791;Cell wall-associated hydrolase, NlpC_P60 family;NlpC;HELO_RS05810;M;;;;HELO_2073;NlpC domain protein;-0.12846548889277065;0.0;0.0;0.10822868178739718;0.23669417068016782
HELO_2074;0.031167804321985;0.09112214274591197;0.0;0.0;0.18522489186502564;0.0;0.053984220646042864;0.09110387925795327;0.0;0.0;0.16098143414464336;0.0;HELO_2074;DUF1833 domain protein;;;;;;;;;HELO_2074;DUF1833 domain protein;-0.08153348442206443;0.0;0.24516083093353944;0.044279124911771404;0.12581260933383584
HELO_2075;313.1037646748654;119.68980900461025;440.3463130817368;500.4837707877798;405.2047095838822;453.3695378759375;1.9521608032581643;3.09865060336362;36.943338680676135;34.944163218081115;16.199126424451055;54.01771119012593;HELO_2075;chorismate mutase domain protein;COG1605;Chorismate mutase;PheA;HELO_RS05820;E;;;;HELO_2075;chorismate mutase domain protein;1.379937373753104;-0.04195497023985162;-0.16165914952753369;-0.5326248815876333;-1.9125622553407373
HELO_2076;1.7942330644583973;0.880283004643637;0.813883509384241;1.1595947503998618;0.8547555690145399;1.0754536909383707;0.373548241467381;0.1629740319494961;0.04664127377175457;0.7567006182081613;0.13792274004133503;0.3340945071762495;HELO_2076;uncharacterized protein;;;;;;;;;HELO_2076;uncharacterized protein;0.5715025388886193;-0.1943449352526989;-0.1621976695855173;0.42902561783841775;-0.1424769210502016
HELO_2077;4.05952308301331;2.2159935735079395;2.619537859018434;3.4963836027471378;2.862899469937366;2.7976265562961835;0.24709851860591736;0.18775491381739515;0.5102971881595025;0.5130424274201466;0.10887930349506951;0.2782727386991474;HELO_2077;phage tail length measure protein;COG5281;Phage-related minor tail protein;;HELO_RS05830;X;;;;HELO_2077;phage tail length measure protein;0.653736877491129;-0.06929253708258343;0.02458608913875371;0.4139033575965374;-0.23983351989459156
HELO_2078;59.35198385417019;58.644446948307284;54.57339486360937;47.080617406828964;78.17414643505346;53.80066294070582;5.5949276588212635;13.844523175490798;4.7907041440931755;7.795958388634259;15.816519265256101;5.918763733347968;higB;mRNA interferase HigB;COG4680;mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module;HigB;HELO_RS05840;JV;higB; mRNA interferase HigB;3.1.-.-;higB;mRNA interferase HigB;0.017013369617536966;0.02020102820977243;0.5308360628290023;0.13920784914166173;0.12219447952412477
HELO_2079;81.55277179090714;61.992674267311514;77.28862585734011;73.96087144949264;94.14806213945644;73.49270734587209;5.160253608732811;4.6662927809665575;9.603937881611769;4.928661145097412;7.026357835344538;1.6163498956804516;higA;antitoxin HigA;COG5499;Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain;HigA;HELO_RS05845;V;higA; antitoxin HigA;;higA;antitoxin HigA;0.3901325957074331;0.0717035250003013;0.35307507756599765;0.14821745969725608;-0.241915136010177
HELO_2080;3.933370308204079;1.5374483134433448;3.256266277393619;3.1571553770283782;6.087766146344727;4.354303905403712;1.2618391550432155;0.5207565436269525;2.276740566122106;1.3416515224468686;1.4577906937488554;0.6398564600740614;HELO_2080;uncharacterized protein;;;;;;;;;HELO_2080;uncharacterized protein;0.9591951472253297;-0.3311106168704159;0.40463197706185916;-0.11812544451272311;-1.0773205917380528
HELO_2081;8.49319214380687;4.202135691979525;3.51501924624382;3.488902448196541;4.219327454998795;3.377351567251328;0.4989870606460799;0.19933170060318386;2.3365025830976776;0.5868060105409041;0.14434212753481407;2.204120559241974;HELO_2081;uncharacterized protein;;;;;;;;;HELO_2081;uncharacterized protein;0.8677892529573885;0.04467387874993278;0.2538056591670266;1.1168350250719041;0.24904577211451562
HELO_2082;4.145313390396818;2.8275231372555467;2.7768510552893826;4.3706364414779175;2.85488801820944;3.763266822630415;0.5830064329202782;0.4821053009571402;0.8106085167749295;0.2693927956294244;0.29229236262442415;0.5153229817327043;HELO_2082;uncharacterized protein;;;;;;;;;HELO_2082;uncharacterized protein;0.42684785256944946;-0.3347674755558099;-0.30526241455282177;0.11130758534271745;-0.315540267226732
HELO_2083;31.575817105869657;41.177089160669176;15.547550258387856;14.200843164521826;14.007232607192279;16.75516480555822;6.426058991057501;2.1466539080770715;1.5471912252051694;1.223803528828499;3.222933482727788;0.8342301336674306;HELO_2083;DUF4128 domain protein;;;;;;;;;HELO_2083;DUF4128 domain protein;-0.37265816473435187;-0.10162109910744643;-0.24258078885212564;0.8755626149729085;1.2482207797072604
HELO_2084;4.718314781669622;2.052143927778864;0.7983298388536705;1.2019074437355506;1.1139041424984042;1.4291911681189695;1.8832293705894732;0.41352535023380904;0.6914935280265545;0.685268255693014;1.0321421993992972;0.6599534406363703;HELO_2084;uncharacterized protein;;;;;;;;;HELO_2084;uncharacterized protein;0.9057670436809038;-0.43381837348397134;-0.2005660715832529;1.2351140105388765;0.3293469668579727
HELO_2085;2.118238561639459;1.418370405386601;0.7457828490374965;0.5773954834590621;0.9889557010524133;0.8082601862459698;0.2249202261876057;0.2677096860463117;0.27481140635496976;0.4274334704344035;0.4364599900921525;0.6999922594510057;HELO_2085;uncharacterized protein;;;;;;;;;HELO_2085;uncharacterized protein;0.36669607668973514;-0.05072815959044985;0.1374088655156641;0.7861290273734077;0.4194329506836726
HELO_2086;2.4686934359831425;1.7195077864839519;1.504076944320767;1.533933308866195;1.568568469994308;1.2742912007961344;0.7683515438123192;0.5022731593227682;1.1019542799464939;0.6733462081903027;0.43795937805651847;0.28147383348566374;HELO_2086;uncharacterized protein;;;;;;;;;HELO_2086;uncharacterized protein;0.35104678397228484;0.13886190445471702;0.17554754285119878;0.608975351420582;0.2579285674482972
HELO_2087;3.895874991512701;2.602363245885345;0.42980293575630285;0.6607395190096211;0.8416782993572088;0.5548465107614643;0.4007745350650517;0.7900528505260429;0.5058138966938763;0.3185990411997861;0.7166320390105544;0.2849276819253653;HELO_2087;uncharacterized protein;;;;;;;;;HELO_2087;uncharacterized protein;0.44262305817687575;-0.12095584977161555;0.24424890701929647;1.6547945521824894;1.2121714940056139
HELO_2088;2.9005691434735943;2.8762652653734926;2.5477753928911118;3.1081736590462454;3.7295084963133918;2.393768153556876;0.3269384991745466;0.7218657916018384;0.39439802778863575;0.16833644704148848;0.2638386290570048;0.6931228567499685;HELO_2088;DUF2184 domain protein;COG4834;Uncharacterized conserved protein, DUF2184 domain;;HELO_RS05890;S;;;;HELO_2088;DUF2184 domain protein;0.009017344774564506;0.06402666650735145;0.4788022524334057;0.20079663715812002;0.1917792923835555
HELO_2089;2.8540786384795553;1.6109143766497407;1.093995199167543;1.3553126823893626;1.9685752988187517;1.9701683587608914;0.392239931270732;0.49586340484375385;0.5255876931637383;0.21721218390334018;0.1565924509593128;0.9429958278502821;HELO_2089;uncharacterized protein;;;;;;;;;HELO_2089;uncharacterized protein;0.5618308625113646;-0.5042865753165655;-0.000774001999751972;0.3758412986601729;-0.1859895638511917
HELO_2090;1.0628895646058816;0.9710417159048381;0.931073377466801;1.0652818692214838;1.5983218559466223;1.0928666403862761;0.2695011959630073;0.19779303739760531;0.3522146473009796;0.38441954390601973;0.14352496841232218;0.4229327551579162;HELO_2090;DUF2213 domain protein;COG3566;Uncharacterized conserved protein, DUF2213 domain;;HELO_RS05900;S;;;;HELO_2090;DUF2213 domain protein;0.06570827911905297;-0.11607739925121918;0.31209976498796643;-0.02081379492054425;-0.08652207403959722
HELO_2091;1.3214432508720912;1.1846800531867807;0.39897289966102795;0.39633954489660495;0.5471040172904287;0.5685339859490064;0.11006668703707109;0.4093170325428951;0.07519661538034039;0.15052925678592466;0.3903498543272986;0.05772540884252904;HELO_2091;uncharacterized protein;COG2369;Uncharacterized protein, contains phage Mu head morphogenesis gpF-like domain;;HELO_RS05905;X;;;;HELO_2091;uncharacterized protein;0.08760000152584246;-0.16504877340809765;-0.019846591322328355;0.5656052248809157;0.4780052233550732
HELO_2092;2.006506043780416;1.0261708852891755;0.7926851636035446;0.9624975849227612;1.242641024381377;0.8651050274545451;0.22536263357625425;0.2130019847431185;0.07741694021511114;0.16622068706762178;0.24116159694560615;0.19760254166238925;HELO_2092;DUF1073 domain protein;COG3567;Uncharacterized conserved protein, DUF1073 domain;;HELO_RS05910;S;;;;HELO_2092;DUF1073 domain protein;0.5693320039192329;-0.05713473324533802;0.26594183568920615;0.6888309851430586;0.11949898122382574
HELO_2093;1.9707840203931013;1.288161269771068;0.8198971781926542;1.3783583782626152;1.0055002358748861;1.1187188456151451;0.37000342290793814;0.1390902207565293;0.1691587870927054;0.11559406904298673;0.30577193504279926;0.23164003573366726;HELO_2093;phage terminase large subunit;;;;;;;;;HELO_2093;phage terminase large subunit;0.3766549863537896;-0.219335212165221;-0.07923001867761914;0.4876515687927119;0.1109965824389223
HELO_2094;1.089658459703698;0.963346002909821;0.9599098935119897;0.946062165357759;0.8330154171189569;0.47762359572804614;0.13426076283146574;0.16629067363092725;0.11464946131716491;0.30879077110111947;0.31619701231617586;0.1767518728044638;HELO_2094;phage terminase small subunit;COG3728;Phage terminase, small subunit;XtmA;HELO_RS05920;X;;;;HELO_2094;phage terminase small subunit;0.08995271984396047;0.4075085186511441;0.3109401105613161;0.49998835341527204;0.41003563357131156
HELO_2095;0.6733646349345895;1.006093565403942;0.5671178266416966;0.5716325057956239;0.39128014533081906;0.31337575253360767;0.2720220811237888;0.19438337568634376;0.26359038181997985;0.07585132036030189;0.263179120635039;0.11055233729315866;HELO_2095;homolog to phiHAP-1 protein gp45;COG3926;Lysozyme family protein;ZliS;HELO_RS05935;R;;;;HELO_2095;homolog to phiHAP-1 protein gp45;-0.2616370452266308;0.2548339299268021;0.08313322161341857;0.3494721248054441;0.6111091700320749
HELO_2096;5.508759932737896;2.310005538912382;2.501286436081466;2.3617455952460413;3.380102493284339;2.739217646548056;0.8070885272418887;0.12564641500035562;0.5168630594553623;0.26890924544633044;0.6787635791717199;0.572678782372342;HELO_2096;uncharacterized protein;;;;;;;;;HELO_2096;uncharacterized protein;0.9755490720336872;-0.09485135602177142;0.2282281811358493;0.7996462554692922;-0.175902816564395
HELO_2097;5.0115350931454765;1.3647115167417523;2.328710282257648;2.07131597576107;2.489556763974127;1.6479027650965214;0.5828932338061111;0.37646899999837846;0.5653928200446829;0.6372580666619804;0.48286163168346175;0.8919991488677059;HELO_2097;uncharacterized protein;;;;;;;;;HELO_2097;uncharacterized protein;1.346069249049127;0.3301131642637489;0.3981936548144174;1.182883296374809;-0.163185952674318
HELO_2098;4.538916475086681;1.7134413465097642;3.188365317520813;4.593458565201317;5.533581050704327;3.475339691524774;1.2727531768133362;0.3963870456931084;0.759472039877729;0.5972108282630826;0.9075787461282822;0.9823221396232236;HELO_2098;uncharacterized protein;;;;;;;;;HELO_2098;uncharacterized protein;1.0294800594727287;-0.09560990887890952;0.5458767572300078;0.3076065919758033;-0.7218734674969254
HELO_2099;5.342327526732304;2.494187221705753;4.087572306814184;4.772454422305748;4.724907244504734;3.1040457691261856;0.6932199419612493;0.3134316377494853;0.319434744180248;1.2898225710561642;0.5674363770143914;0.42489951506375107;HELO_2099;uncharacterized protein;;;;;;;;;HELO_2099;uncharacterized protein;0.860055470942396;0.3099305734870077;0.4802054984620323;0.6279655619170339;-0.23208990902536208
HELO_2100;2.4047528136057323;1.0433369562850274;2.785173140315534;1.7156737378261686;2.841668114022435;1.6375504971401937;0.24680890393344926;0.37497240527851217;0.9545218243289062;1.8005232107919802;0.342283191505256;0.41900695673425287;HELO_2100;uncharacterized protein;;;;;;;;;HELO_2100;uncharacterized protein;0.7366229306346246;0.5211605779106248;0.5425341732021987;0.3683513466546633;-0.3682715839799613
HELO_2101;1.9994404829803332;0.8084032850829633;1.0586109704564177;1.1503405585023596;1.5240765207597005;1.2267191017352006;0.2558849126611861;0.3101942576733491;0.47206215280869507;0.10225561108820339;0.4171257241170994;0.3391994188871679;HELO_2101;uncharacterized protein;;;;;;;;;HELO_2101;uncharacterized protein;0.7299769612946583;-0.11324835519222276;0.18083607306849148;0.42977382966953637;-0.3002031316251219
HELO_2102;1.9556135736664437;0.7495918419216491;0.8621685191238213;0.960030391864556;0.8069459039523421;0.937105638607065;0.2575187766484859;0.16974546403097;0.1871020338723325;0.05962875557990932;0.232530602646291;0.3062597416749214;HELO_2102;HTH domain protein;;;;;;;;;HELO_2102;HTH domain protein;0.7564392608196004;-0.05691899519736365;-0.10034931669798497;0.6095550268868246;-0.14688423393277583
HELO_2103;2.94073977439008;0.6870741255313259;1.206251694425884;1.2044002910459832;1.7839881520116778;1.30979935578008;0.35442003424042895;0.43033638361233345;0.5606885045849427;0.6115995133469213;0.2877508744352336;0.20753478747821133;HELO_2103;BRO_Nterm domain protein;COG3617;Prophage antirepressor;;HELO_RS05990;X;;;;HELO_2103;BRO_Nterm domain protein;1.2239431214867316;-0.06617014880392702;0.269385536240317;0.7706989494777894;-0.4532441720089423
HELO_2104;1.4679141786762429;1.275103826545415;0.6798220597453848;0.6767352833233214;0.5872764819948835;0.6149794010354581;0.7227028005620322;0.3849079806854714;0.14363749465553;0.29706450361336895;0.40403688609113986;0.2275824767482312;HELO_2104;uncharacterized protein;;;;;;;;;HELO_2104;uncharacterized protein;0.11735984028290614;0.056792655694120064;-0.0249623156141785;0.6117764623200229;0.4944166220371168
HELO_2105;659.8869479690064;444.719395203029;681.2776963610978;866.2356234733796;741.0806530300621;688.8631219330023;36.925397292380076;47.22506782818745;44.57576584456476;8.92108018799643;35.63464672082625;46.49530988618446;HELO_2105;HTH/peptidase S24 domain protein;COG1974;SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase);LexA;HELO_RS06005;KT;;;;HELO_2105;HTH/peptidase S24 domain protein;0.5682677635792963;-0.015951084890781786;0.10526585436724112;-0.06190663642407124;-0.6301744000033676
HELO_2106;0.6932464035626792;0.7964338710110185;0.0;0.0;0.2130010388535235;0.0;0.3839779882954147;0.5528057702035913;0.0;0.0;0.3689286213592552;0.0;HELO_2106;uncharacterized protein;;;;;;;;;HELO_2106;uncharacterized protein;-0.08534389740767612;0.0;0.27858078602988634;0.7597919314918715;0.8451358288995476
HELO_2107;1.785798011223383;1.5547368867393165;1.9558664994968964;1.1539254979160558;2.868025835806101;1.5713397795353174;0.009564500554067148;0.11029510929323609;0.31892915717012754;0.411548489107042;0.4351985786439158;0.26137400251883997;HELO_2107;homolog to phage protein;;;;;;;;;HELO_2107;homolog to phage protein;0.12491594166283249;0.20106085021908093;0.5890771690735137;0.11557039479698927;-0.009345546865843213
HELO_2108;2.8932081390621476;3.2960618125218324;2.925672750056746;2.6645282947619435;4.033468046916119;2.738238066377745;0.2044938833909908;0.3601374124314636;0.4948213031896838;0.36809158731610186;0.19739862614521733;0.7037055847174759;HELO_2108;uncharacterized protein;;;;;;;;;HELO_2108;uncharacterized protein;-0.14205527498645365;0.0705814638397051;0.4291943071417388;0.058601027482257484;0.20065630246871113
HELO_2109;3.6622829876418916;3.281794854175358;4.153695735377033;3.3913379111658153;6.124171249121761;3.6107777429573837;0.34216640755009264;0.5008397165411497;0.39437738281893714;0.5308125972754851;0.8211962308899494;0.5871533134913329;rdgC1;recombination-associated protein RdgC;COG2974;DNA recombination-dependent growth factor RdgC;RdgC;HELO_RS06060;L;rdgC1; recombination-associated protein RdgC;;rdgC1;recombination-associated protein RdgC;0.1228208985467445;0.1605972416444339;0.6277120719821889;0.016026450678757076;-0.10679444786798742
HELO_2110;3.931522040690376;2.830294117352292;2.793627113649323;2.929140129263274;6.153508671855746;4.0819317008415235;1.0336115444899678;0.273378952744998;0.03234818909154438;0.5386863569844005;0.33120530342661236;1.216298549987334;ssb2;single-stranded DNA-binding protein;COG0629;Single-stranded DNA-binding protein;Ssb;HELO_RS06065;L;ssb2; single-stranded DNA-binding protein;;ssb2;single-stranded DNA-binding protein;0.3645778047884558;-0.42179910713135094;0.4932740460955465;-0.04334400464259636;-0.40792180943105216
HELO_2111;1.782287215961907;3.837767156774863;3.1171152060493266;2.79482283901728;3.9464107799541295;2.2000723592234066;0.1342376939062264;0.7614437148213365;0.8551775641836158;0.492642255739752;0.6614128484865773;0.13695582968755995;HELO_2111;probable methyltransferase (homolog to DNA-cytosine methyltransferase);COG0270;DNA-cytosine methylase;Dcm;HELO_RS06075;L;;ssb2;2.1.1.37;HELO_2111;probable methyltransferase (homolog to DNA-cytosine methyltransferase);-0.79806997642013;0.36352929170780324;0.6282775275147181;-0.2018331701238434;0.5962368062962866
HELO_2112;1.4266719637994811;2.00172907273956;2.13164865561704;2.2966459571036393;2.777095657152476;2.1390251840811794;0.3629917974706948;0.4157976127907702;0.49865760337975;0.24213505140152358;0.5932959490317132;0.24629312957525737;HELO_2112;uncharacterized protein;;;;;;;;;HELO_2112;uncharacterized protein;-0.30681467047650934;-0.0033942399860393824;0.2669607177721909;-0.37133750462679904;-0.0645228341502897
HELO_2113;2.4307989314809784;2.362330169461502;3.4083570871882913;4.245432069631938;3.7085708359363543;2.898547807509869;0.2607628554612789;0.6501560665425169;0.48926613346292847;1.5983990280287896;0.9872772720738384;0.6781976564729797;HELO_2113;uncharacterized protein;;;;;;;;;HELO_2113;uncharacterized protein;0.029083177168486296;0.17730426403207145;0.27235240750119805;-0.18439224979081437;-0.21347542695930066
HELO_2114;72.5835701317458;63.543323423393794;50.37524954768006;57.096066595558284;43.03852834410503;42.69780308414113;5.035218139877707;10.274252840920086;5.605376474642594;15.28751230175601;3.5397450116020392;2.130221696091603;HELO_2114;HD family hydrolase;COG0317;(p)ppGpp synthase/hydrolase, HD superfamily;SpoT;HELO_RS06100;KT;;;;HELO_2114;HD family hydrolase;0.1891158087024074;0.23351274672415112;0.01120550873446824;0.7518229250021005;0.562707116299693
HELO_2115;3.8611968125459923;3.0651027389417838;2.7515419460033805;3.6553600257553573;4.0149577826818605;2.8413186146771765;0.0729519408880602;0.5105395246722916;0.7358863540081001;0.5580607216468108;1.0645681217171408;0.8820325397698126;HELO_2115;homolog to phage protein T7-7.7;;;;;;;;;HELO_2115;homolog to phage protein T7-7.7;0.25801973033226755;-0.03411794275091795;0.3846359240186148;0.3397099130336896;0.08169018270142203
HELO_2116;81.49988546105241;37.19813873601365;61.737352818468224;66.36051012760016;54.82765468513312;58.44660726967541;1.1729330058335388;1.7467384036844356;6.059101740970491;7.2757728158266985;1.2734268549130967;2.6825044807911254;HELO_2116;integrase family protein;;;;;;;;;HELO_2116;integrase family protein;1.1108897739862567;0.07773018144757327;-0.09061452508609946;0.47279764140466707;-0.6380921325815896
HELO_2117;119.9266170884542;34.03913870729497;58.75550585788995;58.80390853677136;63.87652168753269;60.490164250298015;3.295498752920697;0.7551970010832169;6.70059558566473;0.8359147779588727;8.074843950516957;7.366184224632429;yafJ;probable glutamine amidotransferase YafJ;COG0121;Predicted glutamine amidotransferase YafJ;YafJ;HELO_RS06120;R;yafJ; probable glutamine amidotransferase YafJ;;yafJ;probable glutamine amidotransferase YafJ;1.787092612539169;-0.0412840117075115;0.07734081197513731;0.975704264708714;-0.8113883478304551
HELO_2118;94.95643858873036;48.63483534017413;180.4899636601126;163.5674231561898;189.88945057518401;180.9916161763805;1.9186674310778271;1.5283579177850863;14.232355600259117;7.51477009151248;15.43588156718864;25.628071479909913;fadD;long-chain-fatty-acid--CoA ligase;COG0318;O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming);MenE/FadK;HELO_RS06125;I;fadD; long-chain-fatty-acid--CoA ligase;6.2.1.3;fadD;long-chain-fatty-acid--CoA ligase;0.9510266068307258;-0.0039822213676297125;0.06886538381638196;-0.9234204729059279;-1.8744470797366537
HELO_2119;136.73194147115487;147.94573020356165;150.44128801026713;181.4662742605457;138.24918022849812;153.4714927745057;6.55678897809619;1.8761956148242953;5.710271826847889;4.215628032825444;5.27402899230997;9.639661145002949;hrpA;ATP-dependent RNA helicase HrpA;COG1643;HrpA-like RNA helicase;HrpA;HELO_RS06130;J;hrpA; ATP-dependent RNA helicase HrpA;3.6.4.13;hrpA;ATP-dependent RNA helicase HrpA;-0.11292359246531802;-0.028582031538614494;-0.14967178356184885;-0.1654774436119073;-0.05255385114658928
HELO_2120;241.00714778259757;189.83440336992984;210.45340210396185;229.64326092587945;213.68375307047128;224.03017947020408;1.6932203723821233;8.54123993800688;2.606127051396078;17.740049018713698;9.084329868128169;11.889273908759122;HELO_2120;beta-ketodecanoyl-[acyl-carrier-protein] synthase;COG0332;3-oxoacyl-[acyl-carrier-protein] synthase III;FabH;HELO_RS06135;I;;hrpA;2.3.1.207;HELO_2120;beta-ketodecanoyl-[acyl-carrier-protein] synthase;0.34272837681757373;-0.08977872628356387;-0.06790548413227437;0.10493116016878101;-0.23779721664879272
HELO_2121;366.6204917220503;197.29323847863625;297.02858844640696;295.82633566082274;290.60068041216107;289.69116439889575;4.37204450574808;6.94032537977813;18.936191565091335;21.905899217277067;25.14770717951537;33.23882025076814;mlaA;probable phospholipid-binding lipoprotein MlaA;COG2853;Lipoprotein subunit MlaA of the ABC-type intermembrane phospholipid transporter Mla;MlaA;HELO_RS06140;M;mlaA; probable phospholipid-binding lipoprotein MlaA;;mlaA;probable phospholipid-binding lipoprotein MlaA;0.8905817023436011;0.03596350689835148;0.004506864798935695;0.3387299656606917;-0.5518517366829094
HELO_2122;287.63588945918235;144.73527743698722;201.8221611964997;206.52570196731332;198.3920212991313;196.9507402326017;9.924414728166566;2.8721244387480827;13.969781142588056;18.147914358787517;20.776485068359847;17.26068663818728;HELO_2122;response regulator domain protein / PP2C domain protein;COG2208;Phosphoserine phosphatase RsbU, regulator of sigma subunit;RsbU;HELO_RS06145;KT;;mlaA;3.1.3.3;HELO_2122;response regulator domain protein / PP2C domain protein;0.9859005521268012;0.035073833534306154;0.010466218932577043;0.5441092357410486;-0.44179131638575253
HELO_2123;354.264755592526;185.56952506021483;178.15653553861583;227.10000223346992;190.02233669804062;180.18192090817254;1.7900814272536252;6.497307712550491;10.723821821319214;5.177950947384998;3.718030574403048;11.058090551321142;HELO_2123;STAS domain protein;COG1366;Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor);SpoIIAA;HELO_RS06150;T;;;;HELO_2123;STAS domain protein;0.9291812212970783;-0.01621833112068316;0.07630234149642856;0.9714555673094232;0.04227434601234492
HELO_2124;249.5553039055425;156.08323305531727;466.0882440596786;324.97952241938464;368.63147823643004;478.7928504493563;7.760554771497404;5.941811777162009;64.56520674299061;31.321736474320044;38.166056746936796;5.110777071993192;talA5;transaldolase;COG0176;Transaldolase/fructose-6-phosphate aldolase;TalA;HELO_RS06155;G;talA5; transaldolase;2.2.1.2;talA5;transaldolase;0.6735998812481414;-0.03871652468678555;-0.37632403618574095;-0.9372825817914219;-1.6108824630395633
HELO_2125;126.28356009711074;60.5554877506356;94.079836078843;101.5919084490168;86.73267877771197;96.91725245170407;3.932479349082771;1.7663826352941585;3.2776606773594152;8.664244232611258;3.70856538510355;11.943614684207168;HELO_2125;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS06160;G;;talA5;;HELO_2125;major facilitator superfamily transport protein;1.0480867075853473;-0.042423660697336274;-0.15844875709409045;0.3784111114206432;-0.6696755961647041
HELO_2126;80.65385714647478;129.07533504127235;88.35990968363517;52.6512329863364;46.24509048004898;92.22369021654829;4.5331941402674625;8.84638860711643;9.040307293279884;1.28007893143727;2.007612115012311;13.24247724872579;HELO_2126;ABC-type transport system periplasmic substrate-binding protein;COG0226;ABC-type phosphate transport system, periplasmic component;PstS;HELO_RS06165;P;;;;HELO_2126;ABC-type transport system periplasmic substrate-binding protein;-0.6717544811261202;-0.061068894736213686;-0.9805322043699887;-0.1911755853220214;0.48057889580409885
HELO_2127;13.14478683849291;18.39628471757751;7.862130331506298;4.439813805790634;4.327418157028997;8.811444057330165;0.856026383232904;0.2428936328379663;0.6851253187194964;0.22626614230308267;0.44083518917100306;1.560228538852895;HELO_2127;ABC-type transport system permease protein;COG0573;ABC-type phosphate transport system, permease component;PstC;HELO_RS06170;P;;;;HELO_2127;ABC-type transport system permease protein;-0.4555099007590453;-0.14681194518063911;-0.8810289646129612;0.5277330411643728;0.9832429419234181
HELO_2128;15.93211932411529;18.71839934027079;12.01391228097738;9.23043129210599;6.62116443737064;11.585829840679926;0.07441024464966706;0.4068111692315842;0.9067526650340947;1.0256355272480333;0.9442647155584818;1.6703879473253544;HELO_2128;ABC-type transport system permease protein;COG0581;ABC-type phosphate transport system, permease component;PstA;HELO_RS06175;P;;;;HELO_2128;ABC-type transport system permease protein;-0.21977988356106337;0.04825439148622612;-0.7237169940606525;0.42796221772892284;0.6477421012899862
HELO_2129;32.50511767889477;32.08324079293428;32.4654245481552;27.144452855641138;27.197231340510058;33.63488985048772;0.49535066923679033;0.7199279771998454;4.37182991640506;2.9733592287068236;4.677015965122589;3.820234700044752;HELO_2129;ABC-type transport system ATP-binding protein;COG1117;ABC-type phosphate transport system, ATPase component;PstB;HELO_RS06180;P;;;7.3.2.1;HELO_2129;ABC-type transport system ATP-binding protein;0.018280908223507808;-0.04955476893253152;-0.2966725729143409;-0.04784461137141438;-0.06612551959492219
HELO_2130;25.01251941208875;19.465708376919704;22.287788518314468;17.75740430152538;16.307830351885954;23.362558030941106;0.3143159195826925;2.0182609476390962;2.757338404047169;2.0654737771274454;2.6422148320815566;3.454424023636557;HELO_2130;protein-tyrosine phosphatase domain protein;COG0394;Protein-tyrosine-phosphatase;Wzb;HELO_RS06185;T;;;1.20.4.4;HELO_2130;protein-tyrosine phosphatase domain protein;0.3459975331235672;-0.06509197875488137;-0.4932407370320968;0.0945405146387932;-0.251457018484774
HELO_2131;44.378734310568895;26.321082451665134;25.423449404750546;24.89915653330119;28.94382509539525;28.363276371645487;2.435813320411204;1.2076499361429511;2.348800880005065;1.7122589082459507;2.1657350662308845;2.2092284426756117;gapA2;glyceraldehyde 3-phosphate dehydrogenase;COG0057;Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase;GapA;HELO_RS06190;G;gapA2; glyceraldehyde 3-phosphate dehydrogenase;1.2.1.12;gapA2;glyceraldehyde 3-phosphate dehydrogenase;0.7320017265438219;-0.15219414084804317;0.028245572538409647;0.6280034164497996;-0.10399831009402227
HELO_2132;33.60051478452813;26.588944657771233;23.523202760828386;23.93047863455077;21.057112168520565;21.324103200119456;1.5968543164849929;1.7652074963313034;0.929272262306696;1.7014657615044373;0.3732645399855166;1.6308489874822216;HELO_2132;major facilitator superfamily transport protein;;;;;;;;;HELO_2132;major facilitator superfamily transport protein;0.3267032311006455;0.13554518827958795;-0.0173583026446682;0.6321912815345465;0.30548805043390104
HELO_2133;45.09242365180063;21.997634440238553;21.364054271723536;27.578172696090636;25.272949108654448;22.755297293202727;5.565080608330486;3.1518795460469495;2.324050787275175;4.121712043352905;2.6708896639954607;3.270745406349737;arsR;ArsR family transcription regulator ArsR;COG0640;DNA-binding transcriptional regulator, ArsR family;ArsR;HELO_RS06200;K;arsR; ArsR family transcription regulator ArsR;;arsR;ArsR family transcription regulator ArsR;1.003044158343804;-0.08706751079798636;0.1453288885120534;0.9562803681586933;-0.046763790185110565
HELO_2134;3.563010551550599;1.747126518094322;2.2687932773537214;2.4046401637276147;3.0688903078220746;2.2678808797933776;0.3199967710278808;0.24582731112845121;0.4080275908678009;0.5736684778679746;0.802029137062683;0.6685779952032718;HELO_2134;ABC-type transport system permease protein;COG3639;ABC-type phosphate/phosphonate transport system, permease component;PhnE;HELO_RS06205;P;;arsR;;HELO_2134;ABC-type transport system permease protein;0.7320626350550414;0.0004027465382336892;0.3162799921058923;0.4816305943080019;-0.2504320407470395
HELO_2135;0.9158511747072712;0.30554981130715125;0.4208819583296311;0.412160690731809;0.30118471091976384;0.3478475131218868;0.1999341534170783;0.13703720055718457;0.06846725114388531;0.009995609662408287;0.0581301464428067;0.2079953641820495;HELO_2135;ABC-type transport system permease protein;COG3639;ABC-type phosphate/phosphonate transport system, permease component;PhnE;HELO_RS06210;P;;;;HELO_2135;ABC-type transport system permease protein;0.5533279928100465;0.07612941730873352;-0.05083151268152214;0.5073282069610645;-0.04599978584898207
HELO_2136;0.9184353606849682;0.24555215425469135;0.5984615304647279;0.3963893900362807;0.46978286995722285;0.4928052669091896;0.15476782712018178;0.13543251003023424;0.46550389529167857;0.27860563901880997;0.18974796914486974;0.19052622025126018;HELO_2136;ABC-type transport system ATP-binding protein;COG3638;ABC-type phosphate/phosphonate transport system, ATPase component;PhnC;HELO_RS06215;P;;;7.3.2.2;HELO_2136;ABC-type transport system ATP-binding protein;0.6231447239848202;0.09865804234906361;-0.02242293899490755;0.3619041745065198;-0.2612405494783004
HELO_2137;0.4770485654950522;0.21160074783424468;0.20510519210250786;0.09490560383677647;0.3001753499365743;0.06601155528670147;0.12351286681742021;0.024413944044109025;0.1102164271627199;0.1643813277683006;0.14589756625739936;0.06492736754486135;HELO_2137;ABC-type transport system periplasmic substrate-binding protein;COG3221;ABC-type phosphate/phosphonate transport system, periplasmic component;PhnD;HELO_RS06220;P;;;;HELO_2137;ABC-type transport system periplasmic substrate-binding protein;0.28580288911214147;0.17693600635145512;0.2864831308070412;0.4704941862114143;0.18469129709927284
HELO_2138;186.4286183034861;45.9002368266953;91.38543981999332;102.45612940882654;94.7722713857077;94.93653554905792;9.520771761963806;4.161325728828965;4.690568101395283;14.101766179196991;5.5957735249006015;11.267605435723254;HELO_2138;ABC-type transport system ATP-binding protein;COG4619;ABC-type iron transporter FetAB, ATPase component;FetA;HELO_RS06225;P;;;7.6.2.14;HELO_2138;ABC-type transport system ATP-binding protein;1.9986741407144848;-0.0544148448622499;-0.0024723241007675867;0.966189006468082;-1.0324851342464028
HELO_2139;100.10715840434538;31.213395878687763;54.68861481634354;68.11578631738367;60.09719639763983;52.82738708318836;3.502491276707138;3.0791424109302534;4.6923323113560755;2.7749625656640946;3.907610596192002;2.077451311613372;HELO_2139;ybbM family protein;COG0390;ABC-type iron transport system FetAB, permease component;FetB;HELO_RS06230;P;;;;HELO_2139;ybbM family protein;1.6501524837299604;0.049042012862429374;0.18276578477217686;0.9094728437937665;-0.7406796399361939
HELO_2140;88.4534061433867;60.6522416420161;196.6104138049587;154.34427052306;176.3317181966762;204.1359727220753;6.320382020764109;3.0358082724668;7.101665410011682;3.4810612643350813;4.949413724771857;22.896682483892427;thlA;acetyl-CoA acetyltransferase;COG0183;Acetyl-CoA acetyltransferase;PaaJ;HELO_RS06235;I;thlA; acetyl-CoA acetyltransferase;2.3.1.9;thlA;acetyl-CoA acetyltransferase;0.5369830660523665;-0.05392152852460441;-0.21012990054906844;-1.197372183198155;-1.7343552492505214
HELO_2141;50.38196265893756;24.323090813279396;72.66339776214258;64.27498040651489;55.3567797450842;76.20796973867736;3.85407429069241;1.6170626306963873;12.782140414633314;4.660762737886141;4.810723225135321;5.510282633238108;HELO_2141;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS06240;K;;thlA;;HELO_2141;TetR family transcription regulator;1.0208084946824982;-0.0678018325427594;-0.45416059868868164;-0.5874877778321004;-1.6082962725145986
HELO_2142;12.146866361351693;7.058025547035996;27.265498907087053;56.645397225509335;44.60054849023495;31.123025621332754;0.3973409864409552;0.2011175963316548;4.951437877845551;9.079149156768345;3.013436251592145;4.15607198017161;HELO_2142;acyl-CoA synthetase family protein;COG0365;Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase;Acs;HELO_RS06245;I;;;6.2.1.1;HELO_2142;acyl-CoA synthetase family protein;0.7062206805129523;-0.1845656227557919;0.5054433928318716;-1.2888888195980317;-1.995109500110984
HELO_2143;55.51100634953622;17.173500483852486;50.13980404113493;73.14038270682939;106.20358251203633;53.0775317290016;2.171691244283808;1.1007765199548998;4.068049092253788;10.510117960674418;13.18355937210006;3.4135897586942585;HELO_2143;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS06250;I;;;;HELO_2143;probable oxidoreductase (short-chain dehydrogenase family);1.6366955503192617;-0.08058267148767584;0.987251909318414;0.06350257704942575;-1.573192973269836
HELO_2144;20.051927504160435;8.929274524090504;43.67544877440616;51.150196043571846;50.52926611229492;43.93876085359606;1.6086243814131538;0.7116352641843866;1.6269264939255335;5.43674447824889;13.895531247940703;4.857378015209794;HELO_2144;acyl-CoA dehydrogenase family protein;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS06255;I;;;;HELO_2144;acyl-CoA dehydrogenase family protein;1.0841921146366942;-0.008478122513535524;0.19743170152107758;-1.0940080122425222;-2.1782001268792164
HELO_2145;19.861565513191383;8.907261735237368;24.871142803929786;37.084692525550835;25.46671269450918;22.28952408358488;1.6279257900689228;1.1093469798699545;2.4820357523134784;6.193474513244121;0.9302572574080603;3.725614029029867;HELO_2145;glyoxalase domain protein;COG2764;Zn-dependent glyoxalase, PhnB family;PhnB;HELO_RS06260;C;;;;HELO_2145;glyoxalase domain protein;1.0742891543779747;0.15166262479616055;0.18449785693028886;-0.15883373269088086;-1.2331228870688555
HELO_2146;41.62076575640059;14.658532906152004;45.56535217407373;67.77806236619834;72.87723334677314;37.45428177086233;2.032726458536721;1.4430321156984673;6.833299939405926;6.676181152272899;9.899368955446212;7.132700223469173;HELO_2146;oxidoreductase (homolog to nicotinate dehydrogenase subunit A);COG2080;Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family;CutS;HELO_RS06265;C;;;1.3.99.16;HELO_2146;oxidoreductase (homolog to nicotinate dehydrogenase subunit A);1.444607465252945;0.27611264270378655;0.9419855923937206;0.14841226691735976;-1.2961951983355853
HELO_2147;44.80024507773607;15.086250249158347;63.52957398361866;104.28407451554737;126.88836257760742;58.57467178175776;1.0378595328388307;0.545015651264745;4.078419623336918;2.367645750024647;18.427819580113418;4.472090164166241;HELO_2147;oxidoreductase (homolog to nicotinate dehydrogenase subunit B);COG1529;Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit;CoxL;HELO_RS06270;C;;;1.3.99.16;HELO_2147;oxidoreductase (homolog to nicotinate dehydrogenase subunit B);1.5095272493039689;0.11526140290395137;1.1021139864402612;-0.3793437798891075;-1.8888710291930764
HELO_2148;78.50141872577456;58.550568916438856;63.3745071864584;51.11559799305303;74.74373462506787;68.59228715359899;4.256478464559732;3.5885065600899195;8.069539997439751;2.506531752030681;7.2563380842935175;3.31096553136695;HELO_2148;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS06275;I;;;;HELO_2148;probable oxidoreductase (short-chain dehydrogenase family);0.4168653149921129;-0.11243793962998883;0.12219913415641148;0.19205318350950407;-0.2248121314826088
HELO_2149;30.64085331398029;14.602070250186221;39.59391793808701;62.072831495343166;47.819301307751566;39.278568910190494;0.7575321828836847;0.850896604102462;3.0841107604421616;2.6505173796928316;9.375151797200171;5.973898165855523;HELO_2149;GNAT family acetyltransferase;COG1670;Protein N-acetyltransferase, RimJ/RimL family;RimL;HELO_RS06280;JO;;;2.3.1.-;HELO_2149;GNAT family acetyltransferase;1.0200510339481235;0.011251163461663438;0.2774392221210009;-0.3482239175734865;-1.36827495152161
HELO_2150;33.263564698765485;23.86213125836667;26.586280841124832;34.05852040399269;25.36578908074793;26.912729080521814;3.6720211711801336;0.7121766844416024;1.1992374875158451;4.1260325302519965;2.86651133201259;2.5550600531005134;HELO_2150;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS06285;J;;;;HELO_2150;GNAT family acetyltransferase;0.4627252798001944;-0.016972219448164516;-0.08225601169631513;0.29575206741475135;-0.16697321238544305
HELO_2151;34.64265443481936;14.42265652445753;18.73264797808842;19.402145047203486;20.9116077318317;17.305492425818453;6.859096814007788;1.557644202070771;3.1852325878174854;3.0141946740104015;0.5864115751189254;3.45753409886158;HELO_2151;DUF523 domain protein;COG1683;Uncharacterized conserved protein YbbK, DUF523 family;YbbK;HELO_RS06290;S;;;;HELO_2151;DUF523 domain protein;1.2085534952276165;0.1083079849548918;0.25941876053088286;0.9613282001772632;-0.2472252950503533
HELO_2152;31.497664019633746;59.26709582766345;30.544223955470688;32.73369604033284;38.356385826331895;34.54714440672587;1.6710847808873581;6.193692350260943;1.2750590087002183;3.2257904563490354;4.6518946924568585;4.135424800488537;HELO_2152;glyoxalase domain protein;COG3324;Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family;VOC;HELO_RS06325;R;;;;HELO_2152;glyoxalase domain protein;-0.8910345265581485;-0.17235781076709156;0.14686407215368558;-0.1293976503016081;0.7616368762565404
HELO_2153;22.397089146485968;44.842826046896725;30.817035620136465;26.835622228588736;38.46495552135995;33.99225574984364;1.2917907065931895;3.764030197853589;2.1560178813305897;2.157546670636932;1.7903732678065873;1.1338585166784665;HELO_2153;AhpC domain protein;COG1225;Peroxiredoxin;Bcp;HELO_RS06330;O;;;;HELO_2153;AhpC domain protein;-0.9703669298978657;-0.13723624320413563;0.17353645340621338;-0.5807066158949548;0.3896603140029109
HELO_2154;41.48472924778479;52.93607072660188;45.404587120260395;35.28606523332545;50.64273187382779;51.032019021104986;2.697987473560132;2.3750671217281423;3.5561572793830876;2.5173583348993724;3.3237079683818584;5.746017081757544;HELO_2154;HTH domain protein;COG4519;Uncharacterized conserved protein;;HELO_RS06335;S;;;;HELO_2154;HTH domain protein;-0.3443060535260276;-0.16513226628440414;-0.010834369439183256;-0.29245531920284495;0.05185073432318266
HELO_2155;39.53166836703392;55.69386758328577;59.75621138278626;34.5335962083574;42.97546970528938;67.92628675427588;2.7366308954478784;1.6568972421198316;6.905652673077422;3.9953951629984084;7.037308048402927;3.100187131054005;bioA;adenosylmethionine-8-amino-7-oxononanoate aminotransferase;COG0161;Adenosylmethionine-8-amino-7-oxononanoate aminotransferase;BioA;HELO_RS06340;H;bioA; adenosylmethionine-8-amino-7-oxononanoate aminotransferase;2.6.1.62;bioA;adenosylmethionine-8-amino-7-oxononanoate aminotransferase;-0.4841431304195547;-0.18202238601118825;-0.6483553082072531;-0.766004734611438;-0.28186160419188333
HELO_2156;15.602129900307943;8.362775235205538;11.727646091372248;10.266080152560734;8.965943118071797;10.984997617707258;0.2805245519089579;0.19580183908856;0.6373178416674624;1.4860017818045756;0.2968848991372914;1.2860053285348731;HELO_2156;Lrp/AsnC family transcription regulator;COG1522;DNA-binding transcriptional regulator, Lrp family;Lrp;HELO_RS06345;K;;bioA;;HELO_2156;Lrp/AsnC family transcription regulator;0.826360208068063;0.08673600312316276;-0.2661513774320885;0.4701387157090853;-0.3562214923589777
HELO_2157;19.33727857953317;6.3345436042805785;15.62765622237721;15.745767237454464;17.01371588544929;14.263090268065397;0.560193303146941;0.2874258883748831;1.4546645767205155;0.6401443135606663;2.1841852704166014;1.3987362858750012;HELO_2157;YvoD family protein;;;;;;;;;HELO_2157;YvoD family protein;1.4713475373893963;0.12353773608902952;0.23904872286621703;0.41407954925614643;-1.0572679881332498
HELO_2158;34.83770551989149;4.600351875777464;7.203296388748299;6.407269199002588;5.39508824437674;5.777696183467483;4.411949477926633;0.9262182174024486;0.43739921073078614;2.1176461043298103;0.8778437937521613;0.4943809029665564;HELO_2158;uncharacterized protein;;;;;;;;;HELO_2158;uncharacterized protein;2.6778888918486836;0.2754087864920751;-0.08383070145792493;2.4026113997317005;-0.27527749211698316
HELO_2159;50.01677332937177;3.198954399370411;11.559377759657323;7.734639850744203;8.30285467982938;9.064665905686818;2.2340062367165463;0.6872423235501235;3.476703970312089;1.785366682766945;1.9441918818396775;1.0113783460806192;HELO_2159;uncharacterized protein;;;;;;;;;HELO_2159;uncharacterized protein;3.602869629623848;0.3194657061679309;-0.1135538875397577;2.3416723722137536;-1.2611972574100943
HELO_2160;4.042763262540984;0.7397902309582678;2.063161344576411;2.2898425613507802;4.0065222125177;1.7490245743961708;0.6298198862289281;0.19940776333895333;0.329974960273716;0.5850324289521986;0.6022532341372991;0.5473062239996812;HELO_2160;DHFR domain protein;COG0262;Dihydrofolate reductase;FolA;HELO_RS06365;H;;;;HELO_2160;DHFR domain protein;1.5353011294359482;0.15610155577822726;0.8648889776475284;0.8752946945399658;-0.6600064348959825
HELO_2161;207.75015657895764;74.99595930529894;66.4236504917839;60.25822610338101;80.09976851444146;63.01529837284147;18.08418456302363;13.673835345198512;9.167551952912332;13.253018052543418;14.143054515662946;2.4312297191613608;HELO_2161;uncharacterized protein;;;;;;;;;HELO_2161;uncharacterized protein;1.4577826619100867;0.07483801919229816;0.3412810750137343;1.7052886531027136;0.24750599119262695
HELO_2162;145.25374322744787;77.21609079305067;51.88673143729441;44.725878153456755;68.53750309932467;47.37032090215096;13.550778983420868;3.7436092705975477;7.641257010055831;3.22212842734094;9.851613441107439;2.117672278602549;HELO_2162;uncharacterized protein;;;;;;;;;HELO_2162;uncharacterized protein;0.9029362118948212;0.12878370608717127;0.5236691557252486;1.5962795354276587;0.6933433235328375
HELO_2163;98.2007099274111;37.59403421718827;46.039111098415596;45.99490608258276;42.825006219974775;44.623804656346614;7.978993965195367;2.944624110001772;2.2932217626311395;1.8655977912690835;5.311352549237292;5.27306230535833;HELO_2163;RskA family protein;COG5343;Anti-sigma-K factor RskA;RskA;HELO_RS06385;T;;;;HELO_2163;RskA family protein;1.3619725892294223;0.04407403695026879;-0.05803246502303594;1.1205636844942362;-0.24140890473518617
HELO_2164;319.62600318560004;176.7165563481266;165.92962743236285;152.66813297099262;150.25267510830892;177.05532388983218;11.23435683654634;17.723348788009382;10.721641125657644;9.662210445559946;9.526072050680456;19.63655529981009;HELO_2164;RNA polymerase sigma-70 factor domain protein;COG1595;DNA-directed RNA polymerase specialized sigma subunit, sigma24 family;RpoE;HELO_RS06390;K;;;;HELO_2164;RNA polymerase sigma-70 factor domain protein;0.8513133433605162;-0.09308553968803235;-0.23536491458880793;0.8485658614638707;-0.0027474818966455317
HELO_2165;64.99355223628777;80.73076286648619;192.33744715861474;145.08531749213842;95.56283625786978;170.01804530566426;2.818390421891979;2.882994823557491;13.444111501998517;10.391797122568358;12.47649156573457;11.153868282998666;HELO_2165;DNaseI-type deoxyribonuclease;COG3568;Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family;ElsH;HELO_RS06395;R;;;;HELO_2165;DNaseI-type deoxyribonuclease;-0.30855412472549837;0.1769725354941869;-0.8246086050705381;-1.3737515810199197;-1.0651974562944213
HELO_2166;113.54841178715633;130.62028132873695;104.25513219880833;67.282985076391;102.1537029881866;123.64157916661644;8.89741543958518;1.8400207330916016;4.08012137528943;3.331539061905197;8.4712586550136;4.520048507468648;bioD;dithiobiotin synthetase;COG0132;Dethiobiotin synthetase;BioD;HELO_RS06410;H;bioD; dithiobiotin synthetase;6.3.3.3;bioD;dithiobiotin synthetase;-0.20042435481253662;-0.24389483683687008;-0.27298980539313433;-0.12182796126015116;0.07859639355238546
HELO_2167;100.14476233925376;115.56363636592931;91.24833107163023;55.74964559208764;83.78858155539221;103.96757351943255;6.6895375694402075;6.353028237115882;6.144878799279935;3.0937509735100863;5.388068939607218;7.30194200275062;bioC;malonyl-[acyl-carrier protein] O-methyltransferase BioC;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS06415;H;bioC; malonyl-[acyl-carrier protein] O-methyltransferase BioC;2.1.1.197;bioC;malonyl-[acyl-carrier protein] O-methyltransferase BioC;-0.2046961765195432;-0.18634900504153595;-0.30800182495537065;-0.053522107178927136;0.15117406934061606
HELO_2168;119.47445086199467;131.6799239876585;87.84843661582569;55.870688812687455;74.54480725654771;104.70846074015124;15.183705441009394;5.933418344611403;0.24200778162754488;7.450032679991906;5.521983526373183;7.042310437157575;bioH;pimelyl-(acyl-carrier protein) methyl ester esterase;COG0596;2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold;MenH;HELO_RS06420;HR;bioH; pimelyl-(acyl-carrier protein) methyl ester esterase;3.1.1.85;bioH;pimelyl-(acyl-carrier protein) methyl ester esterase;-0.13922286561490083;-0.2506725565874728;-0.48468635540128346;0.1886363727033329;0.3278592383182337
HELO_2169;178.54704180856754;218.60720790367694;163.14001692621503;91.34495082850363;132.02948267069013;185.17925555477404;20.239786361739302;5.087341907583138;10.106118454274256;2.4664595315695617;6.145946041786451;20.785132307444087;bioF;8-amino-7-oxononanoate synthase;COG0156;7-keto-8-aminopelargonate synthetase or related enzyme;BioF;HELO_RS06425;H;bioF; 8-amino-7-oxononanoate synthase;2.3.1.47;bioF;8-amino-7-oxononanoate synthase;-0.29056352340631175;-0.18176532685635927;-0.4849463154611513;-0.0523304504771156;0.23823307292919615
HELO_2170;179.60358067544317;208.48645626217808;204.84968542117295;94.9844092074714;144.46664775260697;226.45123966631436;12.395824132783899;5.848537595143276;13.740205095421143;5.579055145902482;10.61305003928697;15.104197115707766;bioB;biotin synthase;COG0502;Biotin synthase or related enzyme;BioB;HELO_RS06430;H;bioB; biotin synthase;2.8.1.6;bioB;biotin synthase;-0.21403047748122805;-0.14396605376193428;-0.6448688843445352;-0.3327308014961998;-0.11870032401497177
HELO_2171;17.849604507821887;8.909143347601466;14.54057481742521;21.77540455459615;18.085892040806762;13.464340771129928;1.9711637302053557;2.0428535550470883;1.2858372408026248;2.981548798971297;0.20206038043719157;1.0307151862155102;HELO_2171;ComF family protein;COG1040;DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain;ComFC;HELO_RS06435;R;;bioB;;HELO_2171;ComF family protein;0.9277020080504328;0.1035392950924705;0.40000604485184166;0.3820336816769476;-0.5456683263734852
HELO_2172;66.04694271356685;46.8625499084884;78.77531769022274;85.85523979741372;73.70877226362698;73.1269754167863;2.2190515001510427;2.559019491740085;3.3965376154951437;4.786050456942204;5.429740242404721;5.696540401345873;srkA;stress response kinase SrkA;COG2334;Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist;SrkA;HELO_RS06440;T;srkA; stress response kinase SrkA;;srkA;stress response kinase SrkA;0.4862742884601259;0.10594380209044996;0.011279006744378428;-0.14482709878666444;-0.6311013872467903
HELO_2173;225.95376829092675;193.90682062667284;282.45433271131105;281.76816221393636;250.0628858628902;292.0159456212996;8.966977089674932;11.125670361253423;28.196884567778405;13.036453368501554;8.660733143698133;24.168382036478228;folE1;GTP cyclohydrolase 1;COG0302;GTP cyclohydrolase I;FolE;HELO_RS06445;H;folE1; GTP cyclohydrolase 1;3.5.4.16;folE1;GTP cyclohydrolase 1;0.2196138650945807;-0.04786285525026024;-0.2229304031636481;-0.3685807340702061;-0.5881945991647868
HELO_2174;573.1127089816883;538.2823659989707;445.6385512911823;428.38791371080566;466.5347916524144;544.4817405974433;32.70025262597627;28.548499924045487;32.581050728314786;57.659775670134046;72.10989384071311;39.327607024498526;folX;dihydroneopterin triphosphate 2'-epimerase;COG1539;Dihydroneopterin aldolase;FolB;HELO_RS06450;H;folX; dihydroneopterin triphosphate 2'-epimerase;5.1.99.7;folX;dihydroneopterin triphosphate 2'-epimerase;0.09029313260644045;-0.28842312298550254;-0.22245717742059057;0.07380308779834799;-0.016490044808092463
HELO_2175;288.98318450949864;244.6233288232248;291.5258679366005;332.3682930923239;331.1489438210626;302.0856565152713;10.663110844333275;16.95966335481132;18.268428827944355;3.270632415892436;17.29009156979062;15.347401159277577;gabD2;succinate-semialdehyde dehydrogenase (NAD(P));COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS06455;I;gabD2; succinate-semialdehyde dehydrogenase (NAD(P));1.2.1.16,1.2.1.79,1.2.1.20;gabD2;succinate-semialdehyde dehydrogenase (NAD(P));0.23952165236823575;-0.05116137116552011;0.13210474848707676;-0.06375633446788775;-0.3032779868361235
HELO_2176;212.66918880638045;326.5347878743161;420.8205216090843;351.7474701872414;473.8357527752751;441.65142931598376;15.942829450750182;8.752571350599768;25.585642749395838;28.038923810694993;18.387185473428453;10.892067960129463;purH;phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase;COG0138;AICAR transformylase/IMP cyclohydrolase PurH;PurH;HELO_RS06460;F;purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase;2.1.2.3,3.5.4.10;purH;phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase;-0.6162692594913208;-0.06954179585108378;0.10125748690214742;-1.0507921942242993;-0.4345229347329784
HELO_2177;106.5320758185394;168.24377192268585;125.76348074091625;99.4678854704605;134.224625209779;146.26128179896028;6.849519929173784;7.60551557102218;14.939393006810384;9.046074063201983;18.207528128950973;18.68461806343707;fis;DNA-binding protein Fis;COG2901;DNA-binding protein Fis (factor for inversion stimulation);Fis;HELO_RS06465;K;fis; DNA-binding protein Fis;;fis;DNA-binding protein Fis;-0.6543356778668574;-0.2162389845702295;-0.12302026534982868;-0.45361109772590424;0.20072458014095318
HELO_2178;183.19086017859718;262.4105680442078;173.17317035573834;175.26224060605924;181.40692949391976;174.48187838368298;5.5014410616188165;5.342261654898348;5.394921942196813;0.6043138076227462;12.995069914576291;20.29618152755484;dusB;tRNA-dihydrouridine synthase DusB;COG0042;tRNA-dihydrouridine synthase;DusA;HELO_RS06470;J;dusB; tRNA-dihydrouridine synthase DusB;1.-.-.-;dusB;tRNA-dihydrouridine synthase DusB;-0.5161117531920993;-0.01079964613916129;0.05583848300777561;0.06987942018432758;0.5859911733764269
HELO_2179;198.30860823748387;273.5277129091316;258.2812106470105;198.37515508110673;233.01478190892513;283.97702946892707;10.641993063814443;1.267050541162635;12.883383881183677;11.263445482145018;17.029155361207;11.062696308215855;prmA;ribosomal protein L11 methyltransferase;COG2264;Ribosomal protein L11 methylase PrmA;PrmA;HELO_RS06475;J;prmA; ribosomal protein L11 methyltransferase;2.1.1.-;prmA;ribosomal protein L11 methyltransferase;-0.4619477709235902;-0.13632797366661897;-0.2842459729737854;-0.5158416135088011;-0.053893842585210905
HELO_2180;557.8014780191673;533.7383404021384;538.9455617132343;373.9719489808267;428.13935527712874;583.6543993493468;40.93918098548809;2.9726422723376116;33.06306046285905;13.358549713068353;7.183861040009041;45.083509941564735;accC;acetyl-CoA carboxylase biotin carboxylase subunit;COG0439;Biotin carboxylase;AccC;HELO_RS06480;I;accC; acetyl-CoA carboxylase biotin carboxylase subunit;6.4.1.2,6.3.4.14;accC;acetyl-CoA carboxylase biotin carboxylase subunit;0.06350271588248191;-0.11477011190712894;-0.4461378583548701;-0.06524823474241792;-0.12875095062489983
HELO_2181;663.2493996048073;468.0429502779934;595.4567932566483;413.8967350871307;531.2385264083773;683.1003003466427;19.672246169556498;29.39540100611799;26.961392365921043;16.47852003058699;19.88117913761578;30.303120294321396;accB;acetyl-CoA carboxylase biotin carboxyl carrier protein;COG0511;Biotin carboxyl carrier protein;AccB;HELO_RS06485;I;accB; acetyl-CoA carboxylase biotin carboxyl carrier protein;;accB;acetyl-CoA carboxylase biotin carboxyl carrier protein;0.5020049822866994;-0.197790229125534;-0.36213491892648086;-0.04248284471410635;-0.5444878270008058
HELO_2182;114.4488962302891;24.612698255276005;66.7061178458532;63.39383944102585;55.41325926547603;56.87782471593169;10.553690990688997;1.8763999261157234;2.1419847272394446;2.423077238009574;6.689587582301696;5.608953817515901;dsbD;thiol:disulfide interchange protein DsbD;COG4232;Thiol:disulfide interchange protein DsbD;DsbD;HELO_RS06490;O;dsbD; thiol:disulfide interchange protein DsbD;1.8.4.16;dsbD;thiol:disulfide interchange protein DsbD;2.172323228451595;0.22627549939089953;-0.03697640975468186;0.9961717743819047;-1.1761514540696902
HELO_2183;237.76503774343144;73.97250664450176;240.57641591057245;252.86691003442635;221.73724746510308;191.19785866131687;16.331658215266653;2.5576055227670444;32.84537718806954;42.24256339310279;44.65210052716705;10.946649579586381;HELO_2183;DUF2333 domain protein;COG5345;Uncharacterized conserved protein, DUF2333 domain;;HELO_RS06495;S;;dsbD;;HELO_2183;DUF2333 domain protein;1.671158055490551;0.32988735462080765;0.21275057179309265;0.31299933621743037;-1.3581587192731206
HELO_2184;669.619085164571;503.50545322118836;982.3374549130009;877.7430503530368;1124.079090394338;910.7656845958653;23.56735297987375;46.66308417939146;56.14814300525567;56.30497807296368;183.80756916725662;112.70649113812698;ppa;inorganic pyrophosphatase;COG0221;Inorganic pyrophosphatase;Ppa;HELO_RS06500;C;ppa; inorganic pyrophosphatase;3.6.1.1;ppa;inorganic pyrophosphatase;0.41062367783979603;0.10902348294139408;0.3032914052857567;-0.44316957124333456;-0.8537932490831306
HELO_2185;112.52404672455513;85.31991510555353;112.37607340943157;131.7819256111337;154.9767360803905;123.08746061188866;7.091284076189759;2.9234722450684703;5.498569753537122;8.885266408241332;8.05906452512988;5.128617313352836;HELO_2185;protein phosphatase domain protein / protein kinase domain protein;COG0631;Serine/threonine protein phosphatase PrpC;PTC1;HELO_RS06505;T;;ppa;;HELO_2185;protein phosphatase domain protein / protein kinase domain protein;0.3952325712560425;-0.13024112462149784;0.3299735328370055;-0.12835941210366197;-0.5235919833597045
HELO_2186;382.5139273159554;389.6849087945563;429.8378653422701;452.6601559375383;470.9164102382268;439.7160567381179;25.07460753388444;14.74744025972282;20.375417809514627;14.391332175036219;36.863006817544715;26.45630661101195;pfkA;6-phosphofructokinase (pyrophosphate);COG0205;6-phosphofructokinase;PfkA;HELO_RS06510;G;pfkA; 6-phosphofructokinase (pyrophosphate);2.7.1.11,2.7.1.90;pfkA;6-phosphofructokinase (pyrophosphate);-0.02672655862722806;-0.03270440912640815;0.09868188035792969;-0.20057048952808643;-0.17384393090085837
HELO_2187;217.22035136561988;224.86086559279747;231.96238089466843;245.91099590826875;220.24515868286775;229.58527087160246;10.700678914251537;3.3734041985087364;3.8734884987353206;10.632281030745943;4.840804777521353;4.483539886743611;mpl;UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2%2C6-diaminoheptandioate ligase;COG0773;UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family;MurC;HELO_RS06515;M;mpl; UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase;6.3.2.45;mpl;UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2%2C6-diaminoheptandioate ligase;-0.04964866526823197;0.01479664449145801;-0.05965447440614913;-0.07951470612276346;-0.029866040854531484
HELO_2188;151.5828636708338;180.37396789292464;99.31227618242421;116.59865416411492;121.80806025431421;106.54653131378716;7.437119947401261;12.964880172749599;4.2906084039366394;5.160365993929482;5.790340070781406;1.5963817854039661;ubiX;flavin prenyltransferase UbiX;COG0163;Flavin prenyltransferase UbiX;UbiX;HELO_RS06520;H;ubiX; flavin prenyltransferase UbiX;2.5.1.129;ubiX;flavin prenyltransferase UbiX;-0.2493744600958081;-0.10046282114449845;0.19144425770573648;0.5046319501452965;0.7540064102411046
HELO_2189;119.53618558240969;135.20732566222904;126.72073548743214;146.8613131630477;123.37177351565413;115.53500255143388;4.038615185077182;8.865162884665773;3.8578527583471547;6.42389010724378;8.963208039966995;7.523428566010991;HELO_2189;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS06525;E;;ubiX;;HELO_2189;LysE family transport protein;-0.17633798220997665;0.13222941682285771;0.09389575031146435;0.04870296687768949;0.22504094908766614
HELO_2190;79.61700115163605;21.74637293861133;58.46832492713012;77.06404302248795;59.33318507032118;54.17648310650204;6.076591231101324;0.38459294477441913;3.282242971427014;1.8279727319068602;4.1279408495008365;0.529226499630728;yabI;DedA family protein YabI;COG0586;Membrane integrity protein DedA, putative transporter, DedA/Tvp38 family;DedA;HELO_RS06530;M;yabI; DedA family protein YabI;;yabI;DedA family protein YabI;1.8254476015225807;0.10806793551048877;0.12889824250261483;0.547030614102348;-1.2784169874202327
HELO_2191;60.87779915094827;19.42353689938866;28.685204641703752;35.41308807377016;27.688180794480115;28.52349444028174;3.7996578742604687;1.5139975958463687;0.5212730114652895;1.6351372689821035;0.6624718202922028;6.3392902743032735;HELO_2191;diguanylate cyclase;COG2199;GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants;GGDEF;HELO_RS06535;T;;yabI;;HELO_2191;diguanylate cyclase;1.5991891540638052;0.007880567867943888;-0.04140700552860377;1.067558393581404;-0.5316307604824013
HELO_2192;87.72322086199539;24.54308276509282;39.89782575623789;55.13924561615533;48.69699090353722;42.304209962069415;3.7714055916903777;1.3415087963143435;1.3987522560244217;2.871985394454963;4.584492246952105;2.1876311763676584;HELO_2192;uncharacterized protein;;;;;;;;;HELO_2192;uncharacterized protein;1.7963790869369562;-0.08248314067415485;0.19865121274013742;1.0348044515373989;-0.7615746353995574
HELO_2193;417.8901542913407;398.33477497801863;550.8477542797162;543.2578244540483;560.7722053289082;537.7181314493031;10.150060208980427;15.612744634465171;21.36175364337229;6.861661972200896;7.890092017151385;17.44583611722127;proA;gamma-glutamyl phosphate reductase;COG0014;Gamma-glutamyl phosphate reductase;ProA;HELO_RS06545;E;proA; gamma-glutamyl phosphate reductase;1.2.1.41;proA;gamma-glutamyl phosphate reductase;0.06897326450632058;0.03473968377890202;0.06045462406656732;-0.3629586471763169;-0.43193191168263745
HELO_2194;354.26799898816336;306.6966431659846;294.7118344971405;328.90881145364983;367.1837871926403;311.6241391677715;11.360145549205225;21.8782019775481;8.74949170510203;16.685854744581903;9.881082738568018;5.390730103206616;nadD;nicotinate-nucleotide adenylyltransferase;COG1057;Nicotinate-nucleotide adenylyltransferase NadD;NadD;HELO_RS06550;H;nadD; nicotinate-nucleotide adenylyltransferase;2.7.7.18;nadD;nicotinate-nucleotide adenylyltransferase;0.20739903816961558;-0.08023719804748453;0.23599691980873594;0.1844785629124317;-0.02292047525718388
HELO_2195;405.0423351126442;269.962720477409;379.5948587531528;403.55224074868784;381.6106509210368;340.57342379585964;7.015587478787845;3.2927052988348406;20.115627512903323;30.415636197116235;40.105866218636685;14.444250521069149;rsfS;ribosomal silencing factor RsfS;COG0799;Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits;RsfS;HELO_RS06555;J;rsfS; ribosomal silencing factor RsfS;;rsfS;ribosomal silencing factor RsfS;0.5835357779458121;0.1560603430859402;0.16368130517213686;0.24943442460077847;-0.33410135334503366
HELO_2196;708.3175261678234;510.5983659945371;280.08782883542364;279.23774978076216;287.5288128557067;301.2159189399827;5.608677943907697;57.77631789973282;28.179431483243036;19.59843182816255;24.464760875245833;17.975446919225444;rlmH;23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH;COG1576;23S rRNA pseudoU1915 N3-methylase RlmH;RlmH;HELO_RS06560;J;rlmH; 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH;2.1.1.177;rlmH;23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH;0.47141993848389596;-0.10455866905262923;-0.06686425967809839;1.230851939742914;0.7594320012590181
HELO_2197;107.73879046268534;89.11455622988196;68.54497786919288;68.50951359312238;57.944288553757225;61.648809818247535;2.7886592272954567;2.074891948528063;3.5421327469737864;3.9898255647753587;5.286436964611771;5.745908620060679;mrdA;probable transpeptidase MrdA;COG0768;Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2);FtsI;HELO_RS06565;DM;mrdA; probable transpeptidase MrdA;3.4.16.4;mrdA;probable transpeptidase MrdA;0.27103461685174324;0.15065923359120514;-0.08793507287864166;0.7955076786986313;0.524473061846888
HELO_2198;107.62189168934901;69.62894171794954;56.06504513379363;69.01487206750487;55.27389068084074;57.540800213027666;9.396440411336648;2.6559941046232316;1.4084880608869452;3.0573905877383387;1.2528415572676708;9.407283242464667;rodA;rod shape-determining protein RodA;COG0772;Peptodoglycan polymerase FtsW/RodA/SpoVE;FtsW;HELO_RS06570;D;rodA; rod shape-determining protein RodA;;rodA;rod shape-determining protein RodA;0.6209835087634614;-0.03683516498461703;-0.0569767542252837;0.8918005219904197;0.2708170132269583
HELO_2199;344.24662307250264;155.42852695531602;240.9474847349004;267.4184977432432;230.75049096956204;233.67831470719742;4.411271729296246;1.7460575198704753;22.451633897792508;1.349780529691076;29.22373334335398;16.22584600905504;mltB;lytic murein transglycosylase MltB;COG2951;Membrane-bound lytic murein transglycosylase B;MltB;HELO_RS06575;M;mltB; lytic murein transglycosylase MltB;4.2.2.-;mltB;lytic murein transglycosylase MltB;1.1421236707661748;0.04400940441088519;-0.0181121415073191;0.5569427665094011;-0.5851809042567737
HELO_2200;324.2547643285425;156.87621965406154;163.57993340663805;168.8001943869904;161.99359749769232;154.25119724340325;8.082374719862504;9.663801653127049;10.61878599088657;3.555120547456768;5.853505309012484;6.035722369866618;HELO_2200;RlpA domain protein;COG0797;Peptidoglycan lytic transglycosylase RlpA, contains C-terminal SPOR domain;RlpA;HELO_RS06580;M;;mltB;;HELO_2200;RlpA domain protein;1.0427763102546335;0.08418405021522446;0.07021090144829678;1.066965795627823;0.024189485373189434
HELO_2201;498.0226921573192;203.99591782668696;406.7386357187094;349.91817144392166;414.4862310341245;426.28253080745435;14.085248343738886;7.952594782536204;22.613595319234644;19.508235675862554;38.34144105966412;11.006740734823401;dacA1;D-alanyl-D-alanine carboxypeptidase DacA;COG1686;D-alanyl-D-alanine carboxypeptidase;DacC;HELO_RS06585;M;dacA1; D-alanyl-D-alanine carboxypeptidase DacA;3.4.16.4;dacA1;D-alanyl-D-alanine carboxypeptidase DacA;1.2835102400105463;-0.06754566705045484;-0.04038966676003852;0.2239150865156816;-1.0595951534948647
HELO_2202;456.02942693955293;242.8755934375275;202.04931738437207;194.0461582462178;192.79432914525174;200.5847771077573;10.812107785966498;14.190282944857001;26.81118883269332;15.808841082903562;10.476851827301621;34.77541402012927;HELO_2202;UPF0250 family protein;COG2921;Putative lipoate-binding regulatory protein, UPF0250 family;YbeD;HELO_RS06590;T;;dacA1;;HELO_2202;UPF0250 family protein;0.9061416762288053;0.010443480910224068;-0.056860341383775825;1.1809003633897452;0.27475868716094
HELO_2203;628.9417919445342;399.779610791782;229.36784145566318;189.3298219257655;184.93595044314563;210.59122911418763;11.432999775167476;53.91831600868727;12.678360234361396;4.4021545910658;7.57242649139572;15.659303255823874;lipB;octanoyltransferase;COG0321;Lipoate-protein ligase B;LipB;HELO_RS06595;H;lipB; octanoyltransferase;2.3.1.181;lipB;octanoyltransferase;0.6524094115396775;0.12265950960356076;-0.1864740858579923;1.5739387004111105;0.921529288871433
HELO_2204;432.0119962540702;480.48854805797237;489.2099854366707;558.8172201336223;623.6302545939344;494.3743249103606;5.171333736144206;15.012807638217232;16.847869773978847;14.505920101329975;41.665789283000166;8.091062085396594;lipA;lipoate synthase;COG0320;Lipoate synthase;LipA;HELO_RS06600;H;lipA; lipoate synthase;2.8.1.8;lipA;lipoate synthase;-0.1530944905355227;-0.015119224320834235;0.33448335332590595;-0.1941121018806804;-0.04101761134515769
HELO_2205;32.89936055840705;26.089635018087147;32.06559398108166;34.37037095608122;36.371749171937545;29.588537168277895;1.970680660471753;3.3127882373872053;1.5419169567397897;2.0686136683187315;0.9387983724981352;2.110881276890007;HELO_2205;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS06605;K;;lipA;;HELO_2205;LysR family transcription regulator;0.32351710408181145;0.11233970325303222;0.2889569754225061;0.148266945424389;-0.17525015865742244
HELO_2206;34.3639123445243;20.65696911933166;55.92534943873604;81.80755378415718;66.12201570557981;47.5858694943169;4.507289350728625;1.5672764194808375;4.1564385690366015;6.212461368007299;4.622228966525438;2.6796655695861435;HELO_2206;biotin carboxylation domain protein;COG0439;Biotin carboxylase;AccC;HELO_RS06610;I;;;6.4.1.1;HELO_2206;biotin carboxylation domain protein;0.707446537622741;0.2285344548322632;0.46624925363315484;-0.45825889726820623;-1.1657054348909472
HELO_2207;95.56168562668127;17.58316622104859;23.122326885034436;75.01263884791136;22.18120899601629;20.497722777155758;4.211157338382307;0.6184143188423222;1.5299617142743736;8.249105128723878;0.6072180489208561;1.6379342110918316;HELO_2207;DUF3141 family protein;COG3243;Poly-beta-hydroxybutyrate synthase;PhaC;HELO_RS06615;I;;;;HELO_2207;DUF3141 family protein;2.3774545299936714;0.16618523373010508;0.10877196552722701;2.1672670153848372;-0.21018751460883411
HELO_2208;265.83492903312947;205.10479819037747;306.1527280553931;298.3405465090137;340.6160395550221;316.997709184264;8.873149694146363;3.0039251268336202;21.464638813582038;4.428418227262103;21.724113085253663;13.230355585816548;topA;DNA topoisomerase 1;COG0551;DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains;YrdD;HELO_RS06620;L;topA; DNA topoisomerase 1;5.6.2.1;topA;DNA topoisomerase 1;0.3725694378046738;-0.050060175529207385;0.10335934140848657;-0.2530688430443089;-0.6256382808489827
HELO_2209;385.58438141140596;313.8796104292309;248.83553715089292;242.24635453962733;305.68908881053966;241.2581854215115;4.008348377228043;11.615148772720584;9.949997595492658;12.697184774727786;25.317183901032866;13.05938380430029;HELO_2209;uncharacterized protein;;;;;;;;;HELO_2209;uncharacterized protein;0.2959830108032211;0.04443329137116425;0.3402314279753176;0.6742379394284574;0.37825492862523635
HELO_2210;273.2315499206863;173.51397335785282;261.10825245041065;297.1351255898317;246.51049373303897;290.7863307020041;28.17728551989768;19.224838567362077;5.215987888563991;17.02646660087805;38.729377041541746;19.055779063493834;HELO_2210;YkuD domain protein;COG3034;Murein L,D-transpeptidase YafK;YafK;HELO_RS06630;M;;;;HELO_2210;YkuD domain protein;0.6520520026749157;-0.15474952150344556;-0.23742260637541968;-0.0895177384593655;-0.7415697411342812
HELO_2211;19214.93561122048;4915.892949129654;14149.201807001666;15885.088604768664;14269.980196956529;12013.823589574684;1995.8737200416306;545.5727581673232;1153.6345228294501;2420.7892299805712;1668.9415165343344;816.430777160209;HELO_2211;uncharacterized protein;;;;;;;;;HELO_2211;uncharacterized protein;1.9664843718046825;0.23600716267690736;0.24826896326830372;0.6774877560602715;-1.288996615744411
HELO_2212;266.43816373996043;100.10150647224641;181.75828750690684;174.70363345632768;211.91750368088015;207.16611844455488;12.963024077613142;2.8071302445135276;7.746953203662265;11.77299440312069;11.339283507323787;9.711511522965024;HELO_2212;homolog to L%2CD-transpeptidase;COG1376;Lipoprotein-anchoring transpeptidase ErfK/SrfK;ErfK;HELO_RS06640;M;;;;HELO_2212;homolog to L%2CD-transpeptidase;1.4034008599875643;-0.1877984423730048;0.032559285150669304;0.36147008273372006;-1.0419307772538442
HELO_2213;100.78353503745798;54.48492605194062;93.75563710053933;97.98212370963647;99.78378758393107;98.18421767437623;7.370653840315786;3.071862267811703;0.697551282340549;3.397678243047977;3.9989789845761545;3.5682257207744397;mfd;transcription-repair-coupling factor;COG1197;Transcription-repair coupling factor (superfamily II helicase);Mfd;HELO_RS06645;KL;mfd; transcription-repair-coupling factor;3.6.4.-;mfd;transcription-repair-coupling factor;0.8753364199157181;-0.06589880220644329;0.02308110034918176;0.037321723028299836;-0.8380146968874183
HELO_2214;289.23211453004916;144.19280245638268;267.8886951293777;238.52584688112688;2300.5498242007693;256.6695354900712;14.20804214249383;7.271890498706046;20.548296761615585;15.87539060247319;59.053410836582316;21.197360838656852;HELO_2214;homolog to glyceraldehyde 3-phosphate dehydrogenase;COG0057;Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase;GapA;HELO_RS06650;G;;mfd;1.2.1.12;HELO_2214;homolog to glyceraldehyde 3-phosphate dehydrogenase;0.9992372267958354;0.061487125250776486;3.1590117933087836;0.1716851880688104;-0.827552038727025
HELO_2215;742.5315752497064;718.9879428356408;1307.4174716936823;1326.3416748182958;2199.4029769970048;1311.3147856923495;5.283963236611797;26.491227836702272;137.51116770143406;148.4698541452611;196.3209707394908;108.55063071790883;nqrA;sodium-translocating NADH-quinone reductase subunit A;COG1726;Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA;NqrA;HELO_RS06655;C;nqrA; sodium-translocating NADH-quinone reductase subunit A;7.2.1.1;nqrA;sodium-translocating NADH-quinone reductase subunit A;0.046421263023141535;-0.004290892141025182;0.7456539384208067;-0.8196479065172007;-0.8660691695403422
HELO_2216;665.2752749847834;750.4999725411188;1203.6990959145849;1564.5716599047528;1879.5355626724174;1220.1240807860752;49.2185183306498;35.967600279365286;89.25498106210355;192.9843803862098;26.873424409250855;52.4432608632839;nqrB;sodium-translocating NADH-quinone reductase subunit B;COG1805;Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB;NqrB;HELO_RS06660;C;nqrB; sodium-translocating NADH-quinone reductase subunit B;7.2.1.1;nqrB;sodium-translocating NADH-quinone reductase subunit B;-0.17365469424436064;-0.01953696095922197;0.6229337865233102;-0.8740195405191429;-0.7003648462747822
HELO_2217;522.7305792632335;649.3957064161109;812.9244906299737;1008.7343109114223;1229.7494979618398;750.7720761799875;40.04172930438052;33.99461079930831;41.077695257514684;51.234055146991615;46.281035723641764;19.086789771225178;nqrC;sodium-translocating NADH-quinone reductase subunit C;COG2869;Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC;NqrC;HELO_RS06665;C;nqrC; sodium-translocating NADH-quinone reductase subunit C;7.2.1.1;nqrC;sodium-translocating NADH-quinone reductase subunit C;-0.31249289105149636;0.11459963013801122;0.7111699170515173;-0.5214704864663045;-0.2089775954148081
HELO_2218;575.9205774740138;924.0637351620459;643.1217316419867;766.1892913057895;1045.5351937752687;662.1683698130973;39.92568505007702;51.080324285646334;20.35882666042364;75.87515646970421;77.13900733998874;7.015714389618677;nqrD;sodium-translocating NADH-quinone reductase subunit D;COG1347;Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD;NqrD;HELO_RS06670;C;nqrD; sodium-translocating NADH-quinone reductase subunit D;7.2.1.1;nqrD;sodium-translocating NADH-quinone reductase subunit D;-0.6811800460042132;-0.04204183135309236;0.6581737251457866;-0.20100247628596257;0.48017756971825065
HELO_2219;590.8168133192647;941.695403284128;989.3878213857193;1201.1843364177018;1615.4329575507538;1055.6604946498849;32.66761316262261;59.67777299447398;40.36905634151851;142.78089605988356;103.23670221634039;24.95746961004264;nqrE;sodium-translocating NADH-quinone reductase subunit E;COG2209;Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE;NqrE;HELO_RS06675;C;nqrE; sodium-translocating NADH-quinone reductase subunit E;7.2.1.1;nqrE;sodium-translocating NADH-quinone reductase subunit E;-0.6716410097187815;-0.0934464335785048;0.6133017593309837;-0.8362893240865912;-0.1646483143678097
HELO_2220;754.9253896424507;1159.115329478617;1271.264097259199;1473.9454640072026;1958.557041649333;1227.566170114392;33.387305666415635;66.72193810083735;67.52329927733034;60.18333728862215;64.21990669493839;74.18119255345862;nqrF;sodium-translocating NADH-quinone reductase subunit F;COG2871;Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF;NqrF;HELO_RS06680;C;nqrF; sodium-translocating NADH-quinone reductase subunit F;7.2.1.1;nqrF;sodium-translocating NADH-quinone reductase subunit F;-0.6179524822081213;0.05042261430653028;0.6735520068184826;-0.7006598112181965;-0.08270732901007527
HELO_2221;178.43673922003632;100.96287765191312;411.6215250228622;490.3544363420445;652.072306513985;353.0568579957326;32.77677771380145;15.32453102880593;61.849348715161916;84.71787749079895;70.97481059457823;32.28032838575296;HELO_2221;DUF539 domain protein;COG2991;Na+-NQR maturation protein NqrM;NqrM;HELO_RS06685;OC;;nqrF;;HELO_2221;DUF539 domain protein;0.8154313131010289;0.22083802221579596;0.8832616708310486;-0.9805057526556062;-1.7959370657566351
HELO_2222;153.26840515630417;97.61148799905588;113.42298906623738;129.3332804707221;125.44866910988208;117.52043708427908;12.521586337563795;6.09101443494682;3.2974195651866465;2.529674650178033;6.902216469907062;10.899657368022922;HELO_2222;DUF488 domain protein;COG3189;Uncharacterized conserved protein YeaO, DUF488 family;YeaO;HELO_RS06690;S;;;;HELO_2222;DUF488 domain protein;0.6456149899329775;-0.050758914418689294;0.09341600066326183;0.3803067700622593;-0.2653082198707182
HELO_2223;168.63250080505043;131.87516666510837;174.5147036229723;200.29252858748342;163.80664571327426;178.12295403500397;8.332438773829713;5.440103046101922;11.016762311495702;19.362807167857238;10.057631853878243;14.32334108162693;HELO_2223;TPR domain protein;;;;;;;;;HELO_2223;TPR domain protein;0.3523411087748789;-0.029358329564200147;-0.12017580656918625;-0.07853761583415864;-0.43087872460903753
HELO_2224;372.48342171566196;156.54078889337407;331.19110589163716;285.4079216029932;314.16398453947204;313.97116581514086;17.517555760564793;19.587334588938784;9.325857960765086;26.089820973758737;35.54019407055941;54.57917347578264;HELO_2224;uncharacterized protein;;;;;;;;;HELO_2224;uncharacterized protein;1.2453188004736848;0.07679368454217972;0.000882917342124756;0.24582444323817043;-0.9994943572355144
HELO_2225;136.26711810033004;118.16835422549207;140.05239681718453;140.28645536402453;131.24759159133626;143.52903836239707;9.571598037947991;4.615485847841226;5.3586654135621234;7.934241472585972;9.23026689011836;10.746121247738802;holA;DNA polymerase 3 delta subunit;COG1466;DNA polymerase III, delta subunit;HolA;HELO_RS06705;L;holA; DNA polymerase 3 delta subunit;2.7.7.7;holA;DNA polymerase 3 delta subunit;0.20398490237277933;-0.03512820305710829;-0.12811793488611745;-0.07437331014150939;-0.2783582125142887
HELO_2226;187.10121719841746;177.20387546403833;140.90743860555082;147.93783366867663;152.8595002436313;158.88693485477972;12.988554460317303;6.230533710832366;5.097702258686881;9.592735024045608;7.769595712573981;16.36478824123875;lptE;LPS-assembly lipoprotein LptE;COG2980;Outer membrane lipoprotein LptE/RlpB (LPS assembly);LptE;HELO_RS06710;M;lptE; LPS-assembly lipoprotein LptE;;lptE;LPS-assembly lipoprotein LptE;0.07798047252487095;-0.17210183835023152;-0.055438526553410306;0.23445713058525186;0.1564766580603809
HELO_2227;244.53423186235068;292.8437342161504;403.94297583565594;398.1669847128017;379.2912724232909;407.80959373235146;10.367833765993586;9.311327697753972;16.623364076906316;21.90226942186144;23.496599097611714;19.98697166436421;leuS;leucine--tRNA ligase;COG0495;Leucyl-tRNA synthetase;LeuS;HELO_RS06715;J;leuS; leucine--tRNA ligase;6.1.1.4;leuS;leucine--tRNA ligase;-0.259124959264585;-0.013710291446516365;-0.10432422318779011;-0.7355048770466466;-0.47637991778206157
HELO_2228;193.5731209959716;63.012569694631715;319.0334374244251;284.559832878984;365.6292606035858;313.941258153261;21.65857069181941;0.7670649882959194;32.27219307843144;19.857836908326867;45.02257084424561;8.31464652317649;HELO_2228;DUF1451 domain protein;;;;;;;;;HELO_2228;DUF1451 domain protein;1.60388529515674;0.023139880466203522;0.2192391648672949;-0.6947703417909361;-2.298655636947676
HELO_2229;51.52734660883635;37.789259606742576;33.92500779748395;35.04885622602482;35.542316927126514;31.228636849204225;5.255649773947223;0.6351183530691562;3.4355735522015407;1.4495434742802238;1.831684825492166;2.2424953061663353;HELO_2229;uncharacterized protein;;;;;;;;;HELO_2229;uncharacterized protein;0.4374114707863077;0.11591726865240837;0.1812249403416315;0.7047255402717294;0.2673140694854217
HELO_2230;19.831786281037793;5439.66063768863;53.61023394803942;16.94099537850752;93.32992495434479;117.73609674039592;2.796285582248372;244.95559734659415;16.80900786697143;1.2612039060367655;49.20861980237837;110.07418559976162;HELO_2230;uncharacterized protein;;;;;;;;;HELO_2230;uncharacterized protein;-8.02885147989171;-1.1205153503172847;-0.3319711676490238;-2.510900134898824;5.517951344992887
HELO_2231;34.826726256360885;9.784705598955329;37.474848404780964;29.356342269122806;30.42415103832974;33.35124816505901;2.211302832197024;0.8244242115235385;3.834000437014769;3.2567060544059885;6.058897135183947;0.765111638176546;HELO_2231;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS06735;K;;;;HELO_2231;LysR family transcription regulator;1.7320494259039205;0.16355312134112854;-0.12848875183265918;0.06067369938711131;-1.6713757265168092
HELO_2232;411.6825324868035;329.40145971087077;504.34518046314673;366.1701536462352;428.980300167183;492.57699857087096;22.343542283735843;7.9487250432699295;28.207073096467283;18.26066199424862;34.699759666041224;38.14424718346566;leuC;3-isopropylmalate dehydratase large subunit;COG0065;Homoaconitase/3-isopropylmalate dehydratase large subunit;LeuC;HELO_RS06740;E;leuC; 3-isopropylmalate dehydratase large subunit;4.2.1.33,4.2.1.35;leuC;3-isopropylmalate dehydratase large subunit;0.32081231444908553;0.03399400579387546;-0.19900460100096318;-0.25824278926396005;-0.5790551037130456
HELO_2233;335.4926632248558;346.7250881544596;451.2357013916981;371.1564649759619;391.4317073327749;457.4853623050276;16.14521576521707;18.943824869903608;35.193631396583235;27.756147832328185;9.344632140753701;40.11490078433849;leuD;3-isopropylmalate dehydratase small subunit;COG0066;3-isopropylmalate dehydratase small subunit;LeuD;HELO_RS06745;E;leuD; 3-isopropylmalate dehydratase small subunit;4.2.1.33,4.2.1.35;leuD;3-isopropylmalate dehydratase small subunit;-0.0473721112626837;-0.01980078577605049;-0.22443406298535074;-0.44630062565516226;-0.39892851439247856
HELO_2234;425.68418872219354;397.36575341161415;592.7177783700607;411.96751699674843;491.46899890752366;598.0853615043578;16.265053382544945;10.668516222037375;34.70733786955375;7.615300090623833;29.656000860717693;22.105334225343945;leuB;3-isopropylmalate dehydrogenase;COG0473;Isocitrate/isopropylmalate dehydrogenase;LeuB;HELO_RS06750;CE;leuB; 3-isopropylmalate dehydrogenase;1.1.1.85;leuB;3-isopropylmalate dehydrogenase;0.09907502323106598;-0.012984268034051283;-0.2827286727745495;-0.4895929312636138;-0.5886679544946798
HELO_2235;494.7421205492462;1108.50370749224;1049.24228329235;876.8120273501482;1155.3538718028892;1089.4098108599117;34.201946389951175;40.7636726370093;79.67771553050873;29.210975055027912;52.06695506463552;100.69100616288885;asd;aspartate-semialdehyde dehydrogenase;COG0136;Aspartate-semialdehyde dehydrogenase;Asd;HELO_RS06755;E;asd; aspartate-semialdehyde dehydrogenase;1.2.1.11;asd;aspartate-semialdehyde dehydrogenase;-1.162252741230951;-0.0541482622378755;0.08471251659440604;-1.1372087006385385;0.025044040592412387
HELO_2236;229.45212236483647;180.69414180645512;220.31993712211124;241.3758888385254;232.77699161845774;214.72679312946795;3.608072021939499;2.1252216511854827;10.14318664066797;8.15723081303731;12.700396278176347;17.964237755018985;truA;tRNA pseudouridine synthase TruA;COG0101;tRNA U38,U39,U40 pseudouridine synthase TruA;TruA;HELO_RS06760;J;truA; tRNA pseudouridine synthase TruA;5.4.99.12;truA;tRNA pseudouridine synthase TruA;0.3429551494751433;0.036928049591927525;0.11592757707580414;0.09526168490997211;-0.24769346456517116
HELO_2237;168.10427883214697;141.40805362640302;112.93770789649835;118.04990080172608;130.94561864481634;123.23438727831342;7.262863057884811;1.9210485189470599;9.232389567885074;7.4532939707226005;4.747921855630043;10.300356819898129;trpF;N-(5'-phosphoribosyl)anthranilate isomerase;COG0135;Phosphoribosylanthranilate isomerase;TrpF;HELO_RS06765;E;trpF; N-(5'-phosphoribosyl)anthranilate isomerase;5.3.1.24;trpF;N-(5'-phosphoribosyl)anthranilate isomerase;0.2478824270231943;-0.12481926884950667;0.0868788881367033;0.4448486070772839;0.1969661800540896
HELO_2238;394.83419168184963;334.88031530287026;316.3460556604871;351.89677466625;320.55402282163794;312.6124459097383;14.974890736561827;11.856023613912503;8.762109945466833;16.423358276036346;4.611463103658121;8.675029288782053;trpB2;tryptophan synthase beta subunit;COG0133;Tryptophan synthase beta chain;TrpB;HELO_RS06770;E;trpB2; tryptophan synthase beta subunit;4.2.1.20;trpB2;tryptophan synthase beta subunit;0.23694898897732308;0.017074096407961648;0.03607832365461583;0.33591342117086853;0.09896443219354545
HELO_2239;315.4351729227252;221.5375719259841;282.7632153899785;304.7698117588123;292.6727533436694;301.609086552379;10.419456583399054;4.133130278885252;9.545876205131261;8.24684692718135;5.55710970080122;34.76305039337187;trpA2;tryptophan synthase alpha subunit;COG0159;Tryptophan synthase alpha chain;TrpA;HELO_RS06775;E;trpA2; tryptophan synthase alpha subunit;4.2.1.20;trpA2;tryptophan synthase alpha subunit;0.5078610368037051;-0.09276772552372314;-0.04324588842226795;0.06445466100511688;-0.4434063757985882
HELO_2240;725.4903644790157;676.0764687724544;707.2936709613231;760.1274871600253;695.5340581569207;716.5301022121948;16.259470576358062;38.880890230111774;17.706400220935862;28.04400749870184;27.561393691731965;9.129701918948573;accD;acetyl-CoA carboxylase carboxyltransferase subunit beta;COG0777;Acetyl-CoA carboxylase beta subunit;AccD;HELO_RS06780;I;accD; acetyl-CoA carboxylase carboxyltransferase subunit beta;6.4.1.2,2.1.3.15;accD;acetyl-CoA carboxylase carboxyltransferase subunit beta;0.10162488290306726;-0.01869170680349619;-0.04284546032948455;0.017904305580106694;-0.08372057732296057
HELO_2241;491.73510970104826;415.61058858266966;370.9251842393998;389.18445362747065;360.9501001696001;357.12939251135504;5.6648079856864575;9.777176445292755;7.960943619591671;8.579382966471176;22.446766525231688;8.301570321948581;folC;dihydrofolate synthase / folylpolyglutamate synthase FolC;COG0285;Folylpolyglutamate synthase/Dihydropteroate synthase;FolC;HELO_RS06785;H;folC; dihydrofolate synthase / folylpolyglutamate synthase FolC;6.3.2.12,6.3.2.17;folC;dihydrofolate synthase / folylpolyglutamate synthase FolC;0.24211276673108095;0.05453151188428329;0.015309886688665841;0.4603313452886084;0.21821857855752747
HELO_2242;313.65978903736453;321.6201216519372;200.64410351030656;229.05571737513696;186.1173126515497;183.01709129723722;7.119303326219971;10.352897427407047;9.505995498780528;11.20268159014197;7.6839513439524305;11.125566327129212;HELO_2242;uncharacterized protein;COG3147;Cell division protein DedD (periplasmic protein involved in septation);DedD;HELO_RS06790;D;;folC;;HELO_2242;uncharacterized protein;-0.036043595731928946;0.1319714506077272;0.024103278827152685;0.7739530573466045;0.8099966530785334
HELO_2243;313.66680191836554;224.65782082234944;162.54865343753264;175.78515885016986;156.7685940415159;152.6152782242821;15.400791822402788;2.9122099407381734;6.176277222486912;9.813729195238055;5.201818940140795;12.322410677851137;HELO_2243;CvpA family protein;COG1286;Colicin V production accessory protein CvpA, regulator of purF expression and biofilm formation;CvpA;HELO_RS06795;MF;;;;HELO_2243;CvpA family protein;0.4796881987998809;0.09039817083097823;0.0384883357547956;1.0345032686280948;0.5548150698282139
HELO_2244;318.1466179192493;218.2845209199385;313.6721058283342;328.6358811957086;280.03308100311887;306.9699950480476;16.96418425908207;11.918203997300486;9.056307247001897;13.900245899580193;10.450985885968068;13.963161416243564;purF;amidophosphoribosyltransferase;COG0034;Glutamine phosphoribosylpyrophosphate amidotransferase;PurF;HELO_RS06800;F;purF; amidophosphoribosyltransferase;2.4.2.14;purF;amidophosphoribosyltransferase;0.5414153820830112;0.031059497680002934;-0.13204983548317273;0.051429560621155446;-0.48998582146185576
HELO_2245;336.75213159629294;277.4260965240132;420.2588667248481;471.71709762096333;469.1925699798883;436.20574423806465;20.160275388943763;9.036856870939289;16.735638561438982;20.0794567208;16.894376402381933;12.460360003860279;metZ;O-succinylhomoserine sulfhydrylase;COG0626;Cystathionine beta-lyase/cystathionine gamma-synthase;MetC;HELO_RS06805;E;metZ; O-succinylhomoserine sulfhydrylase;2.5.1.-;metZ;O-succinylhomoserine sulfhydrylase;0.2786704351140674;-0.053605303324495424;0.10493938557269189;-0.37234748140741303;-0.6510179165214804
HELO_2246;179.6475165127971;139.52952470362297;195.2708353323716;178.6835098899303;178.69562686765175;211.0497008545907;6.442083782552392;6.062941769169223;5.962439356126882;14.733967876124618;7.652808559852148;6.108058912829857;HELO_2246;cytochrome domain protein;COG3038;Cytochrome b561;CybB;HELO_RS06810;C;;metZ;;HELO_2246;cytochrome domain protein;0.36230415429546703;-0.11155663476944344;-0.2388471483086967;-0.2312250265056246;-0.5935291808010916
HELO_2247;332.5448170941365;289.7410475129364;242.73400179751593;203.48742431361634;230.9065510233488;213.76233824704775;26.938204485340417;20.16967363306161;6.314531029089687;37.90424781891709;12.79996598136538;22.25517724754238;HELO_2247;UPF0312 family protein;COG2353;Polyisoprenoid-binding periplasmic protein YceI;YceI;HELO_RS06815;R;;;;HELO_2247;UPF0312 family protein;0.19814585467224255;0.18256650882433512;0.11080255701247932;0.6351396060576473;0.43699375138540475
HELO_2248;153.4444839397888;9.428266181686132;14.775918142588838;11.261217130958338;124.2218158381407;24.440966454253513;1.7006506727865924;0.8991438428433439;5.188355685433595;0.8473636644810452;32.240578618201795;19.450201142375523;HELO_2248;uncharacterized protein;COG4340;Predicted dioxygenase, 2-oxoglutarate and Fe-dependent (2OG-Fe) dioxygenase superfamily;;HELO_RS06820;R;;;;HELO_2248;uncharacterized protein;3.8885171269411485;-0.6894295058689979;2.299260544929693;2.6018629632923114;-1.2866541636488371
HELO_2249;64.04182837768523;19.03197999522327;153.39856775198265;159.58061001613612;71.59163092649422;90.61219542445225;3.550178011135878;1.3965281544221413;34.12098580626288;19.373357379197433;32.50143261854114;49.002109564530706;HELO_2249;diguanylate cyclase / EAL-type diguanylate phosphodiesterase;COG5001;Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain;;HELO_RS06825;T;;;;HELO_2249;diguanylate cyclase / EAL-type diguanylate phosphodiesterase;1.6990627866435197;0.7530478018661126;-0.33573643300436373;-0.49417184952032134;-2.193234636163841
HELO_2250;60.10391008310611;52.16408925999817;41.95983298689095;47.2115865199744;48.24242843216408;41.107075595125934;2.785303372246868;0.8122603496853308;2.268106212584259;2.998182053599377;3.5914883345685427;1.9294684677077192;HELO_2250;MATE family transport protein;COG0534;Na+-driven multidrug efflux pump, DinF/NorM/MATE family;NorM;HELO_RS06830;V;;;;HELO_2250;MATE family transport protein;0.2008126244093189;0.02892570316069154;0.22583922983794302;0.5372020206204748;0.33638939621115593
HELO_2251;51.75071429982935;101.44787577515733;34.67101496787282;64.92557393690858;25.527538812814957;32.55529753888248;1.946552293654655;6.953228038074615;6.680108551638788;2.3341718607127198;3.0096887858317385;5.504916472485249;dadA;D-amino acid dehydrogenase small subunit;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS06835;E;dadA; D-amino acid dehydrogenase small subunit;1.4.5.1;dadA;D-amino acid dehydrogenase small subunit;-0.9576275361621844;0.08821171649284754;-0.339049719137428;0.6526500798251131;1.6102776159872976
HELO_2252;1092.3921779431494;1279.2864341544941;1793.3706025629253;1273.9706898386005;1584.6358019315228;1933.4558927058;35.91601216118832;84.7188136481746;123.03037670963175;109.094368426586;106.8426872354443;74.72894423797783;phhC;aspartate aminotransferase / aromatic amino acid aminotransferase;COG1448;Aspartate/aromatic aminotransferase;TyrB;HELO_RS06840;E;phhC; aspartate aminotransferase / aromatic amino acid aminotransferase;2.6.1.1;phhC;aspartate aminotransferase / aromatic amino acid aminotransferase;-0.22765565587944536;-0.10844994459574941;-0.28686639195205466;-0.8231168747013449;-0.5954612188218995
HELO_2253;77.68120067335407;88.21011288034192;82.10707142875118;56.92746783846153;61.414454319963085;78.07496977493258;12.037428767841142;30.038721239976326;22.000787766140895;10.630740813205916;20.400828513833194;13.66482173287776;phhB;pterin-4-alpha-carbinolamine dehydratase;COG2154;Pterin-4a-carbinolamine dehydratase;PhhB;HELO_RS06845;H;phhB; pterin-4-alpha-carbinolamine dehydratase;4.2.1.96;phhB;pterin-4-alpha-carbinolamine dehydratase;-0.18118829040240492;0.07175013920457207;-0.3413409234003657;-0.007202126018714061;0.17398616438369086
HELO_2254;3.2137112265347523;1.8038195477188184;3.0686253411000526;2.853978943344964;3.9532399930211213;2.836835863428394;0.22981439463685602;0.2771901504472327;0.5749566978906603;0.6878929812006542;0.26221238481379755;0.3068403339918728;phhA;phenylalanine 4-monooxygenase;COG3186;Phenylalanine-4-hydroxylase;PhhA;HELO_RS06850;E;phhA; phenylalanine 4-monooxygenase;1.14.16.1;phhA;phenylalanine 4-monooxygenase;0.5876979456908593;0.08462438712468612;0.3684554747337023;0.13517439797406783;-0.4525235477167915
HELO_2255;44.25965725208584;31.91437944562151;48.861027627964454;50.46715364103459;47.369850427726355;50.73312373270445;0.31643127144760785;0.9668985224251293;6.165024852114205;3.4062053503541856;3.3817733227169176;3.845483548409346;phhR;ACT/PAS/sigma-54-interact/HTH domain transcription regulator PhhR;COG3283;Transcriptional regulator TyrR of aromatic amino acids metabolism;TyrR;HELO_RS06855;KE;phhR; ACT/PAS/sigma-54-interact/HTH domain transcription regulator PhhR;;phhR;ACT/PAS/sigma-54-interact/HTH domain transcription regulator PhhR;0.4595076612023945;-0.05317568966148656;-0.09698022991705191;-0.19286264728873448;-0.652370308491129
HELO_2256;21.252455947264423;13.029204349844095;23.22655188707343;21.220542577007382;18.406312487181605;23.609299333983046;1.7987226303243111;0.3380324241370147;0.6040029803921361;0.9196552587170108;0.21312172912542096;1.4205905011180973;HELO_2256;uncharacterized protein;;;;;;;;;HELO_2256;uncharacterized protein;0.6655313809766734;-0.02261449882720523;-0.3426775738175909;-0.1452390110830688;-0.8107703920597422
HELO_2259;42.40408622387046;16.18371728254858;22.41525502546519;30.298282972271114;29.4598418571877;20.236628436637087;1.8570574584753932;0.13682231042765558;1.8647013020289382;1.9101486034376942;2.9025291538711806;1.6920364292528742;cfa1;cyclopropane-fatty-acyl-phospholipid synthase;COG2230;Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases;Cfa;HELO_RS06875;I;cfa1; cyclopropane-fatty-acyl-phospholipid synthase;2.1.1.79;cfa1;cyclopropane-fatty-acyl-phospholipid synthase;1.3367887073046107;0.1408940115298094;0.5203537119981734;1.0312761302031754;-0.3055125771014353
HELO_2260;40.74811842285854;25.150109513689994;58.672442397827865;64.65691734740287;65.34727890999432;57.235298634854246;4.623449486212239;2.2867254626123352;13.04699863766399;4.8617725993394645;6.687907636164408;5.832883876648921;HELO_2260;UPF0045 family protein;COG0011;Thiamin-binding stress-response protein YqgV, UPF0045 family;YqgV;HELO_RS06880;H;;cfa1;;HELO_2260;UPF0045 family protein;0.6748941888232736;0.03517093698788809;0.18814340705851684;-0.4801827135853358;-1.1550769024086094
HELO_2261;26.601303327366992;18.582371218867564;20.007637931264476;24.34868391916761;28.402705789854735;20.756265246639284;0.17737109707531268;1.7839177711250758;1.254549479097243;1.3572033985084393;1.459732460902449;1.0596985725843193;hpd;4-hydroxyphenylpyruvate dioxygenase;COG3185;4-hydroxyphenylpyruvate dioxygenase and related hemolysins;HppD;HELO_RS06885;ER;hpd; 4-hydroxyphenylpyruvate dioxygenase;1.13.11.27;hpd;4-hydroxyphenylpyruvate dioxygenase;0.49518092165792993;-0.05051696341520362;0.43451800548928254;0.34330547236894127;-0.15187544928898866
HELO_2262;249.33339767037296;129.08880372037632;269.6436093903965;279.7707285847446;255.99695770145559;287.84414244865474;7.548185338267274;0.7569826770171824;18.295622211450926;16.38506394216933;16.445721993617312;4.726171620279913;HELO_2262;NSS family transport protein;COG0733;Na+-dependent transporter, SNF family;YocR;HELO_RS06890;R;;hpd;;HELO_2262;NSS family transport protein;0.9443539780197083;-0.09389691553863244;-0.16853995708463465;-0.2064404603585972;-1.1507944383783055
HELO_2263;68.05564160426991;52.49881557133676;65.84794525551638;67.1117118448424;66.25275255711547;57.87138351184987;2.220410369505977;7.571571401604299;4.626922885042486;7.965085464501558;8.351274646896972;1.3410160408024545;sirA1;uroporphyrin-III C-methyltransferase;COG0007;Uroporphyrinogen-III methylase (siroheme synthase);CysG;HELO_RS06895;H;sirA1; uroporphyrin-III C-methyltransferase;2.1.1.107;sirA1;uroporphyrin-III C-methyltransferase;0.36825233088840736;0.18331668381289656;0.19202678405841933;0.23019275021047214;-0.13805958067793522
HELO_2264;1035.761017990825;595.52468470266;332.60501236112924;481.11564939389586;646.2800896898312;338.24722698759666;43.29965546161081;23.23995295175989;34.582853446277475;15.789538667474117;63.88304216924033;19.495876013051657;HELO_2264;RlpA domain protein;COG0797;Peptidoglycan lytic transglycosylase RlpA, contains C-terminal SPOR domain;RlpA;HELO_RS06900;M;;sirA1;;HELO_2264;RlpA domain protein;0.7974296350812811;-0.02419605787527601;0.9320531042337965;1.6116744511148084;0.8142448160335274
HELO_2265;20.968438356138424;15.548645338070585;21.50996012652364;21.256923470352504;23.91246510111468;20.509626641477826;1.1615385301724708;1.3889506309041866;0.8553353113132947;1.3757443247604495;0.9312904042497783;1.823538952862095;HELO_2265;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS06910;T;;;2.7.13.3;HELO_2265;sensor histidine kinase;0.4087191945478734;0.06558101819523365;0.21188530099957337;0.030449835233227418;-0.378269359314646
HELO_2266;36.463041576528155;31.27479542207324;27.87831542976001;25.49249507433274;30.061459551675654;27.56252490812408;1.409243237057304;1.8335638116819164;4.583266942509634;2.0404375112042294;1.533071450529218;1.1087504060842084;HELO_2266;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS06915;KT;;;;HELO_2266;response regulator/HTH domain transcription regulator;0.2150600840509327;0.015863069094675275;0.12100210405374501;0.3913445166227181;0.1762844325717854
HELO_2267;46.43874508549889;38.19274021107407;63.94025726497625;66.81937997042066;83.10796353223219;68.48217031791263;4.097589316991963;1.1276504124193831;1.9569231523495678;2.284274516507461;9.40155334932503;8.563132345880685;HELO_2267;IclR family transcription regulator;COG1414;DNA-binding transcriptional regulator, IclR family;IclR;HELO_RS06920;K;;;;HELO_2267;IclR family transcription regulator;0.2754794018939215;-0.09752971824662726;0.2755995863667522;-0.5505769719621849;-0.8260563738561064
HELO_2268;95.60331900317986;15.868580131931076;100.33366298576338;105.67858845170309;167.7904592000214;113.18791885717125;8.82525782427768;0.9537480454728824;5.010441487877085;8.47416530556032;11.546594789826186;7.041151001456385;HELO_2268;TTT family transporter substrate-binding protein;COG3181;Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC;TctC;HELO_RS06925;C;;;;HELO_2268;TTT family transporter substrate-binding protein;2.517734212929361;-0.17229650462660295;0.5638233378339708;-0.24126535912582803;-2.758999572055189
HELO_2269;67.14410797854718;17.38339201737151;18.41550719962368;21.724674064840496;26.48412412057743;18.739343928453753;1.509753055843417;1.4740851293450636;3.0009539038764212;2.5967557732903015;1.76192973234652;2.09784862074946;HELO_2269;TTT family transporter small transmembrane protein;;;;;;;;;HELO_2269;TTT family transporter small transmembrane protein;1.8901859305230602;-0.02386464422342538;0.47752446339312726;1.7875148809385282;-0.10267104958453199
HELO_2270;46.52736692899254;10.687115888355981;38.57196463316811;35.79390906357502;61.33889672512967;41.965669145321975;4.103441190016979;0.6445049820278231;1.5807886118154038;4.42166266825075;8.415530574173516;1.8598869535852167;HELO_2270;TTT family transporter large transmembrane protein;COG3333;TctA family transporter;;HELO_RS06935;R;;;;HELO_2270;TTT family transporter large transmembrane protein;2.023839527075967;-0.11870567091739392;0.5369482587207219;0.145574113256294;-1.878265413819673
HELO_2271;1.3626429399117017;2.3641714512983953;2.536483820105617;3.41949430679157;1.6598067200876205;2.6448767686790746;0.3472902790162811;0.45136062332810933;0.45036614802086955;0.9284464037290814;0.1892588596237698;0.2518946950752727;HELO_2271;ABC-type transport system periplasmic substrate-binding protein;COG0683;ABC-type branched-chain amino acid transport system, periplasmic component;LivK;HELO_RS06940;E;;;;HELO_2271;ABC-type transport system periplasmic substrate-binding protein;-0.5098496178003478;-0.04355437784199312;-0.45454862527704165;-0.6254684236017014;-0.11561880580135364
HELO_2272;1.2766280327637627;1.8750276398132317;1.7192434032764001;1.7544578655432221;0.8946110744868019;1.62544819548996;0.20542877988728023;0.29111182189854806;0.04839153870671688;0.3261054799646572;0.02392700402369955;0.27419936070431206;HELO_2272;ABC-type transport system permease protein;COG0559;Branched-chain amino acid ABC-type transport system, permease component;LivH;HELO_RS06945;E;;;;HELO_2272;ABC-type transport system permease protein;-0.33667723007331163;0.050641565644930386;-0.4706620066059527;-0.20566513337862102;0.1310120966946906
HELO_2273;0.9280425921994082;1.5177025901117884;0.6107830538555211;0.6718948928684242;0.6693214752690416;1.011849732411817;0.0867239283838116;0.26760296764576996;0.14076729635417365;0.08385808216473437;0.09286074004418302;0.31630497596502893;HELO_2273;ABC-type transport system permease protein;COG4177;ABC-type branched-chain amino acid transport system, permease component;LivM;HELO_RS06950;E;;;;HELO_2273;ABC-type transport system permease protein;-0.38497094882323546;-0.3207603527681101;-0.2692607390917413;-0.061385630105163735;0.3235853187180717
HELO_2274;1.6032934676288215;2.8926774914104016;1.4764308125320176;1.2484341038768028;1.1511346503628;1.2264485764618343;0.46952241205655976;0.177854836258648;0.46941812442669845;0.27073893354291345;0.2613069725501124;0.3554344673399979;HELO_2274;ABC-type transport system ATP-binding protein;COG4674;ABC-type uncharacterized transport system, ATPase component;;HELO_RS06955;R;;;;HELO_2274;ABC-type transport system ATP-binding protein;-0.5804248672455199;0.1535180242506542;-0.04964645757730013;0.22559366428979244;0.8060185315353123
HELO_2275;2.08455405552701;3.4413457375422865;1.8582743749293573;1.6968729784556313;1.7965991036512883;2.103469909774392;0.25551713004855353;0.6469168657579235;0.6371749098072111;0.6536558073995848;0.28660898264435786;0.15708533285282786;HELO_2275;ABC-type transport system ATP-binding protein;COG0410;ABC-type branched-chain amino acid transport system, ATPase component LivF;LivF;HELO_RS06960;E;;;;HELO_2275;ABC-type transport system ATP-binding protein;-0.5259349534708397;-0.11873774608161303;-0.15020870178230128;-0.008820228968728916;0.5171147245021108
HELO_2276;6.2789975816056085;26.149158796804233;13.979685510941138;16.96860224339746;12.473624033716277;12.482986779681307;0.42762616002716625;2.748312662564356;0.554718632245909;3.0354654810255735;0.873343557471204;1.321256421512454;ureD;urease maturation protein UreD;COG0829;Urease accessory protein UreH;UreH;HELO_RS06965;O;ureD; urease maturation protein UreD;;ureD;urease maturation protein UreD;-1.8990958073291684;0.15186721486861243;-0.0010021725512543433;-0.8893284305686615;1.0097673767605069
HELO_2277;5.703357815325568;19.57665590959489;10.670761305018805;8.87835128548719;5.30387595310453;6.30164569505418;0.6352926922153811;6.192779183795661;2.6765883065134517;0.5332167997723772;1.7588012954016692;1.9703128416889442;ureA;urease gamma subunit;COG0831;Urease gamma subunit;UreA;HELO_RS06970;E;ureA; urease gamma subunit;3.5.1.5;ureA;urease gamma subunit;-1.618052686487144;0.676605103468928;-0.211982519260681;-0.12333772033124335;1.4947149661559007
HELO_2278;3.7591869054904365;9.675230869587907;1.7245670159048252;2.75224703671592;2.358006181987567;1.994170244238349;0.6614501472705697;0.7891036714267452;0.3498874751292576;0.890463111348293;1.4654111326760546;0.8108203416595681;ureB;urease beta subunit;COG0832;Urease beta subunit;UreB;HELO_RS06975;E;ureB; urease beta subunit;3.5.1.5;ureB;urease beta subunit;-1.165480251795771;-0.1361292761276094;0.1654486329298206;0.6685588606444113;1.8340391124401823
HELO_2279;6.799534427672287;16.377195832699428;10.837448410635927;14.552214955617586;10.239094049965338;11.001636134483173;0.3038919206206853;1.7370313773278265;0.8106950861086992;2.625510825408209;0.28258391794502014;1.4361805143074045;ureC;urease alpha subunit;COG0804;Urease alpha subunit;UreC;HELO_RS06980;E;ureC; urease alpha subunit;3.5.1.5;ureC;urease alpha subunit;-1.1557353786317535;-0.01987295778997744;-0.09470534713984913;-0.6217711821779277;0.5339641964538258
HELO_2280;9.83604660283993;17.35930201102779;7.441781487089062;10.133901592922234;4.270400403687641;7.75644105866597;0.5317735409538746;2.2697014073912958;1.3616042970368392;0.8158242267470187;1.5210478579609121;1.674937909968551;ureE;urease maturation protein UreE;COG2371;Urease accessory protein UreE;UreE;HELO_RS06985;O;ureE; urease maturation protein UreE;;ureE;urease maturation protein UreE;-0.7606727077207966;-0.052797138296873936;-0.7324320536789775;0.30742197382621406;1.0680946815470107
HELO_2281;10.319053765991745;16.88717432440592;16.30676063287407;20.010646033952764;12.57909825160378;14.958383400174192;0.7975844330068231;1.6610312940683951;1.611200039029231;5.2700654458492115;1.640274386979001;1.6193433991991506;ureF;urease maturation protein UreF;COG0830;Urease accessory protein UreF;UreF;HELO_RS06990;O;ureF; urease maturation protein UreF;;ureF;urease maturation protein UreF;-0.6601721408735433;0.11702120313372388;-0.23292683496082622;-0.4955611536838238;0.16461098718971945
HELO_2282;9.56072141867507;16.679961135276674;11.8433168729736;14.166145076089675;13.769589124216393;14.04278050013754;1.605670886399915;1.3050523348145735;1.3949276577302987;2.854893090220316;1.2398399092482901;1.7927436734059803;ureG;urease maturation protein UreG;COG0378;Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase;HypB;HELO_RS06995;O;ureG; urease maturation protein UreG;;ureG;urease maturation protein UreG;-0.7434067126303137;-0.22805342242602755;-0.026441566433995423;-0.5103628679859287;0.233043844644385
HELO_2283;20.621579939455106;35.6887291216209;20.90167231696859;26.771585249019903;24.13874014982433;21.788590948347316;1.169910438051292;2.6573393227316697;4.100815903585254;5.131191867794856;1.191657176577115;4.091451483957268;ureJ;urease accessory protein UreJ;COG2370;Hydrogenase/urease accessory protein HupE;HupE;HELO_RS07000;O;ureJ; urease accessory protein UreJ;;ureJ;urease accessory protein UreJ;-0.7628649832227206;-0.057270691447053323;0.14160062620067304;-0.07583977540471754;0.687025207818003
HELO_2284;71.67202294412564;44.73849722868963;60.954986536862606;83.84536144800984;66.01126145032045;60.254580181734546;4.043222890691641;0.6503654713050017;4.252629266761106;4.720975544599067;5.179065101571213;4.021726607952209;HELO_2284;phospholipase domain protein;COG1502;Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase;Cls;HELO_RS07005;I;;ureJ;;HELO_2284;phospholipase domain protein;0.667991100905156;0.016402681819733367;0.1295858427008536;0.2465823440273356;-0.4214087568778204
HELO_2285;31.330981925590265;9.795533679912287;18.29072932467044;15.403513712078734;19.487466300146238;17.360854952529618;1.389456062702124;0.5053410699272328;1.5965365641993077;0.1969030606917144;0.23185124992483955;2.029997934096193;HELO_2285;BrkB family protein;COG1295;Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase);BrkB;HELO_RS07010;S;;;;HELO_2285;BrkB family protein;1.5824827591660333;0.0712744506091747;0.1581083384508215;0.8162840864948322;-0.7661986726712011
HELO_2286;280.6560132337351;358.40452465359385;441.84533906437804;341.93016378775565;562.32025868721;423.2506030052766;18.05000962140997;17.790976515685276;62.848252091088796;20.654789899379566;48.69541138194446;40.753716713720934;HELO_2286;uncharacterized protein;COG1196;Chromosome segregation ATPase Smc;Smc;HELO_RS07015;D;;;;HELO_2286;uncharacterized protein;-0.3516742986720178;0.06188622428635071;0.40903864582138816;-0.590982437512988;-0.23930813884097013
HELO_2287;195.0759953572485;82.41995125770097;156.80775390215788;133.92942415682074;146.1897854397871;141.26811129417885;8.025437243100232;2.99218786471632;24.394850312450966;21.037665449250778;6.63588625377214;12.176822049323281;apbC;iron-sulfur cluster assembly protein ApbC;COG0489;Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family;Mrp;HELO_RS07020;D;apbC; iron-sulfur cluster assembly protein ApbC;;apbC;iron-sulfur cluster assembly protein ApbC;1.2329485497402644;0.14955576906256685;0.04906523084303416;0.4628005990958757;-0.7701479506443887
HELO_2288;322.4574185959412;296.0477370225887;251.62312176087195;251.367511117183;236.79422426604992;256.76364054769306;5.05103716827744;8.358025594139908;36.93488974503466;7.138187115692515;18.870902270187628;20.296015183365878;dcd;dCTP deaminase;COG0717;dCTP deaminase;Dcd;HELO_RS07025;F;dcd; dCTP deaminase;3.5.4.13;dcd;dCTP deaminase;0.12288100398939505;-0.029062085046716923;-0.11633510114028667;0.32752702645578147;0.2046460224663864
HELO_2289;51.609335829621536;14.61003187457115;33.617844288829836;46.5544771377558;36.56729803358535;30.65741602959567;1.9634625115330713;1.7065473486897957;2.685440202949193;4.084422100797753;1.404504448536724;2.6950836349495484;HELO_2289;YjbR domain protein;COG2315;Predicted DNA-binding protein with 'double-wing' structural motif, MmcQ/YjbR family;MmcQ;HELO_RS07030;K;;dcd;;HELO_2289;YjbR domain protein;1.7528453535802662;0.12897238515017406;0.24693385291796943;0.7327753334655451;-1.020070020114721
HELO_2290;10.666495646726641;8.864871805549193;12.204214251829091;17.366273577905904;13.972844816097412;10.860980725761905;0.6194978079492263;0.9749464788417547;0.24958211214497653;1.0747441152239445;2.286092510906266;1.6710079929032489;HELO_2290;SGNH family hydrolase;COG5571;Uncharacterized conserved protein YhjY, contains autotransporter beta-barrel domain;YhjY;HELO_RS07035;R;;;;HELO_2290;SGNH family hydrolase;0.24199906463172027;0.15477514893513833;0.3361250530200861;-0.02385203119641588;-0.26585109582813615
HELO_2291;269.1552894827026;191.24893251216326;213.97005525523744;198.60349024679712;256.0182028528603;227.31708505285005;10.498281636445741;11.01506788354137;8.792600636512827;8.117449224047078;7.497872571062191;10.349531828378618;purN;phosphoribosylglycinamide formyltransferase;COG0299;Folate-dependent phosphoribosylglycinamide formyltransferase PurN;PurN;HELO_RS07040;F;purN; phosphoribosylglycinamide formyltransferase;2.1.2.2;purN;phosphoribosylglycinamide formyltransferase;0.4908133419150156;-0.0869031107015017;0.1708317183126873;0.2427501083562955;-0.24806323355872006
HELO_2292;256.33558029807836;191.41274381593425;296.3993227949364;279.84572972348036;340.36905521472875;291.4980476163403;9.763917825394344;16.98660155486779;5.483322618734063;7.555779206358243;23.393266060065358;26.739845992509654;purM;phosphoribosylformylglycinamidine cyclo-ligase;COG0150;Phosphoribosylaminoimidazole (AIR) synthetase;PurM;HELO_RS07045;F;purM; phosphoribosylformylglycinamidine cyclo-ligase;6.3.3.1;purM;phosphoribosylformylglycinamidine cyclo-ligase;0.4194465895746866;0.023974367307365796;0.22290529039789497;-0.18477605100176753;-0.6042226405764541
HELO_2293;123.66151433588358;64.30926547786966;132.0130983454122;181.17394515449112;132.4302142356274;126.67326543113825;4.199745999623536;2.324598293836247;5.371743185692794;9.011591410423016;5.120385314635918;10.160980917876396;HELO_2293;uncharacterized protein;COG0628;Predicted PurR-regulated permease PerM;PerM;HELO_RS07050;R;;purM;;HELO_2293;uncharacterized protein;0.9326565555162505;0.05911186209050179;0.06362893187216034;-0.0344403155068127;-0.9670968710230632
HELO_2294;150.99922889870186;73.32354614730787;105.37014830789205;121.88219630412716;117.38934420336803;98.7342561358319;5.852628530474723;3.2057486651515155;7.856844729636238;10.73557207836181;7.7825506661033;4.8327595417554585;hda;DnaA regulatory inactivator Hda;COG0593;Chromosomal replication initiation ATPase DnaA;DnaA;HELO_RS07055;L;hda; DnaA regulatory inactivator Hda;;hda;DnaA regulatory inactivator Hda;1.032172762034536;0.092932306796075;0.24737821178278185;0.6079029815426846;-0.4242697804918514
HELO_2295;82.08185959504851;43.53229515370458;39.77121313054925;64.29340133227626;59.75381301295575;37.49384015462105;2.8335694606489956;4.336616014600273;5.017666925980778;6.409110295630282;5.559801145021021;2.802592659676122;HELO_2295;ABC-type transport system periplasmic substrate-binding protein;COG0834;ABC-type amino acid transport/signal transduction system, periplasmic component/domain;HisJ;HELO_RS07060;TE;;hda;;HELO_2295;ABC-type transport system periplasmic substrate-binding protein;0.8996815390538293;0.08292328233062118;0.6583473556345627;1.109905906004327;0.21022436695049773
HELO_2296;288.48243045959435;115.64764365857638;185.45648867754088;218.8110654599167;178.37681028670218;184.54855013442202;10.26896783951763;8.159475596728445;8.10354506231981;12.017091268583982;5.3985635224691215;2.3064514158251255;HELO_2296;uncharacterized protein;;;;;;;;;HELO_2296;uncharacterized protein;1.3113186250182682;0.007042275764274741;-0.04880333627605804;0.6416790615205752;-0.669639563497693
HELO_2297;261.7248504481719;8.437385457778719;10.792456228650115;207.6046501927233;9.776076383644464;11.040812230896478;6.280592945494532;1.287506421170437;2.710013106687211;86.7183835481482;0.9081508732681695;2.0927885001128375;HELO_2297;uncharacterized protein;;;;;;;;;HELO_2297;uncharacterized protein;4.799021628066917;-0.030068468651333724;-0.1601007323713426;4.447548047998383;-0.3514735800685336
HELO_2298;51.506024606866795;51.95340771996967;93.25837823529874;81.83431396050453;119.85920214500861;97.47454999796213;1.4455005905063487;4.659834620189841;14.878243428379513;3.5501324868620014;13.672891974022853;15.512741238762938;fumC;fumarate hydratase%2C class II;COG0114;Fumarate hydratase class II;FumC;HELO_RS07075;C;fumC; fumarate hydratase, class II;4.2.1.2;fumC;fumarate hydratase%2C class II;-0.012240560305050607;-0.06313005988456677;0.29550449895371234;-0.9072679502205743;-0.8950273899155237
HELO_2299;147.13329397184052;38.78712100017268;138.15565458143786;214.27771342859646;199.27492975529;120.09861273766602;4.529907248656678;4.823166485988545;20.38079144010268;16.456818389275902;23.040549145964995;8.629887544050284;HELO_2299;PagP domain protein;;;;;;;;;HELO_2299;PagP domain protein;1.8965225182858356;0.20051719555536884;0.7257994989903898;0.2907135945284649;-1.6058089237573707
HELO_2300;38.28789121643292;26.280778624285006;42.35545853170088;48.22889429920438;42.34529853680627;44.35329882079725;4.015051166862866;1.7159920125639756;6.914037498521633;3.1267919576891234;2.305292263244804;2.4630551573093866;panE;2-dehydropantoate 2-reductase;COG1893;Ketopantoate reductase;PanE;HELO_RS07085;H;panE; 2-dehydropantoate 2-reductase;1.1.1.169;panE;2-dehydropantoate 2-reductase;0.5261999118995666;-0.06499384770781713;-0.06533197103713029;-0.20712275754243414;-0.7333226694420008
HELO_2301;60.671209656961196;41.86430983922333;76.21708466377184;86.03275888061751;64.8306721425596;77.98806495199803;0.8159657695787548;2.0749409047682548;2.4616271119572506;1.7322883173517758;6.645023250829069;3.6785468315076186;topB1;DNA topoisomerase 3;COG0550;DNA topoisomerase IA;TopA;HELO_RS07090;L;topB1; DNA topoisomerase 3;5.6.2.1;topB1;DNA topoisomerase 3;0.5248202298309304;-0.03271459316477099;-0.2628747514266605;-0.35703753492484935;-0.8818577647557797
HELO_2302;40.24860915543093;32.44701260360559;69.01366579640629;73.72639238510969;67.08793878503529;69.7865632744486;1.0838412375774797;0.9010340516632451;6.321984128042845;1.6194012974156502;6.533064736314295;1.4749683691631965;HELO_2302;UbiB domain protein;COG0661;Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family;AarF;HELO_RS07095;TH;;topB1;;HELO_2302;UbiB domain protein;0.3024681155337108;-0.01583898784964699;-0.05607627413284888;-0.7791300589648893;-1.0815981744986
HELO_2303;151.05986979278302;210.61449111129514;250.39587448219382;283.27864225772794;207.31240713450643;236.77732660288066;8.817583632295603;1.1892299881679922;10.243921635288537;5.542386152494481;13.216067916209528;7.316695553013118;HELO_2303;uncharacterized protein;;;;;;;;;HELO_2303;uncharacterized protein;-0.4767989640721124;0.080349822080934;-0.1908623834227745;-0.6449716917851465;-0.16817272771303404
HELO_2304;46.584061394088536;36.843719497121285;45.003382919752234;64.16480139991246;48.49624687249644;45.38481114554504;1.021259634005453;1.2436105954898016;0.9212460876482497;5.241128335968767;3.5573650484435815;1.1752417059272977;HELO_2304;major facilitator superfamily transport protein;;;;;;;;;HELO_2304;major facilitator superfamily transport protein;0.33042452194047023;-0.011912512024038868;0.09366666722698369;0.03682594631652325;-0.293598575623947
HELO_2305;124.1003991749709;115.3274068679818;119.29251684737513;145.22669162903642;162.47631281274997;118.1460831583643;8.853091491550314;8.907562120900776;7.020635641499096;6.431565635010777;13.713059130452182;12.978585000751261;rfaH;transcription elongation factor RfaH;COG0250;Transcription termination/antitermination protein NusG;NusG;HELO_RS07110;K;rfaH; transcription elongation factor RfaH;;rfaH;transcription elongation factor RfaH;0.10489535548240791;0.013815373435618561;0.45635008428894697;0.07035486816788694;-0.03454048731452097
HELO_2306;91.80350319938698;144.37407948344932;83.84388655421088;74.88377316467493;86.48235019223041;85.05155118001302;4.451630356153317;6.612750312343339;4.663055146604536;8.494858274860169;2.9829397357353615;2.0282194027442713;slyD2;FKBP-type peptidyl-prolyl cis-trans isomerase SlyD;COG1047;Peptidyl-prolyl cis-trans isomerase, FKBP type;SlpA;HELO_RS07115;O;slyD2; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD;5.2.1.8;slyD2;FKBP-type peptidyl-prolyl cis-trans isomerase SlyD;-0.6475188853384131;-0.0203904889785278;0.023790779792806305;0.10897806728517079;0.7564969526235839
HELO_2307;242.9423587162984;214.78579464624747;336.54983191631817;340.9185756656659;335.20159015587654;341.28739691664003;11.32345765112866;3.6844211675257883;22.339315257346307;14.520934499225408;29.90328217597378;8.971915152333596;proS;proline--tRNA ligase;COG0442;Prolyl-tRNA synthetase;ProS;HELO_RS07175;J;proS; proline--tRNA ligase;6.1.1.15;proS;proline--tRNA ligase;0.17694039862749644;-0.020107672496807893;-0.025881624830880412;-0.4886678802398876;-0.665608278867384
HELO_2308;34.10057340636003;30.399060060246786;33.999213413732235;26.573080879035285;33.047021292568736;35.76535145169563;1.2380643922667423;2.2037424290581584;2.503280999636977;1.4950334307839206;2.9855056722170152;2.682477376401043;HELO_2308;carbon-nitrogen hydrolase domain protein;COG0388;Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate;Nit2;HELO_RS07180;C;;proS;;HELO_2308;carbon-nitrogen hydrolase domain protein;0.1607732264492121;-0.0710242774541241;-0.11081819098745616;-0.06685217744489691;-0.227625403894109
HELO_2309;32.21376138185988;21.886387127242273;27.47571392083964;20.698418126483677;29.87561024472829;28.767679866959124;3.251894377648354;2.8644228383042925;1.9708660249814425;1.3632687315639287;4.439465100702039;3.6329210888979175;HELO_2309;GNAT family acetyltransferase;;;;;;;;;HELO_2309;GNAT family acetyltransferase;0.5372913786946292;-0.06401476785511306;0.05272087093529443;0.15803433361382435;-0.3792570450808048
HELO_2310;43.756875508945946;14.142809730603567;30.450491618437628;26.470911153163822;30.532668556400434;34.85203020397603;0.34821911783318005;0.6500700035834437;4.620550251249223;2.18959387051081;2.3703004152641154;2.9121290016054733;HELO_2310;BenE family transport protein;COG3135;Predicted benzoate:H+ symporter BenE;BenE;HELO_RS07190;Q;;;;HELO_2310;BenE family transport protein;1.5634764043151903;-0.18897224840565485;-0.18520754914888737;0.3200545076736576;-1.2434218966415327
HELO_2311;140.96235113922054;66.14861817912852;172.2235178209979;187.73115361929874;186.0824826957968;158.70345603224507;10.042794465184192;2.498990630286723;14.51963251737256;2.5058342446762754;7.529337225398291;4.311798023276344;HELO_2311;PuuR family transcription regulator;COG3257;Ureidoglycine aminohydrolase;AllE;HELO_RS07195;F;;;;HELO_2311;PuuR family transcription regulator;1.0800787566997538;0.11723927848332316;0.2282789459632264;-0.16988716024888362;-1.2499659169486375
HELO_2312;32.79918826450777;19.17910450017983;24.432191686342687;30.667581945380693;26.353168578144096;21.942091393378814;1.2520669018077688;0.5784249223772039;1.7802878847666148;3.8838646752924353;1.6145125771369127;1.3648113068414613;amiD;N-acetylmuramoyl-L-alanine amidase AmiD;COG3023;N-acetyl-anhydromuramyl-L-alanine amidase AmpD;AmpD;HELO_RS07200;M;amiD; N-acetylmuramoyl-L-alanine amidase AmiD;3.5.1.28;amiD;N-acetylmuramoyl-L-alanine amidase AmiD;0.7441264460033299;0.1486588824980526;0.253711050865129;0.5589916856078556;-0.18513476039547427
HELO_2313;39.43676369842333;27.91506298957454;31.976154663982356;38.01787303552276;37.27902215210039;32.80877058693152;2.273616209179231;3.800338915812017;1.990310784870658;1.3449726889833264;3.545489206415743;4.700202922221258;HELO_2313;uncharacterized protein;;;;;;;;;HELO_2313;uncharacterized protein;0.48384629277728486;-0.03597437890957522;0.1791564208529568;0.2582699823094634;-0.22557631046782145
HELO_2314;48.642347269738444;40.66769985087529;49.833354205086174;52.019425534487716;52.99016727142682;48.54601162699112;3.554190863239018;3.985524444028226;2.5073914803474424;2.5750247500820667;2.2053395738609285;7.1463678236113735;HELO_2314;nucleotide cyclase domain protein;;;;;;;;;HELO_2314;nucleotide cyclase domain protein;0.2526418706372544;0.03700650170894537;0.12392775903606612;0.002802405429417121;-0.24983946520783729
HELO_2315;20.044833267361792;16.517105145778782;18.931771215560385;17.689642778784982;23.15529256832582;17.79080533145921;0.7089461151133583;1.6546694918056903;2.0575555824867107;0.6895123257946077;1.1442636903974654;2.958661009184311;HELO_2315;uncharacterized protein;COG3825;Uncharacterized CoxE-like protein,  contains von Willebrand factor type A (vWA) domain;CoxE2;HELO_RS07215;S;;;;HELO_2315;uncharacterized protein;0.26470170291962436;0.08504302069485092;0.36231242803094865;0.1634391809009843;-0.10126252201864006
HELO_2316;35.73809569803421;23.956186759617964;42.47648942623355;40.23485595718935;55.612099493993014;43.92218797348198;3.0359413987013255;1.0367866898520415;0.7271143128824138;2.987190501914265;4.121718738054023;3.6452238037468416;HELO_2316;AAA-type ATPase domain protein;COG0714;MoxR-like ATPase;MoxR;HELO_RS07220;R;;;;HELO_2316;AAA-type ATPase domain protein;0.5578793359737784;-0.04719274462980749;0.3336822307285825;-0.29015135017602756;-0.8480306861498059
HELO_2317;19.522418735561775;9.354351839709013;13.190956506025435;15.767214914066637;57.89656182157685;14.135232770115673;0.47952806672619;1.778206648264788;1.7595864911357872;2.1211589700914186;5.2221685958649156;2.7103392039196126;HELO_2317;oxidoreductase (3-hydroxyisobutyrate dehydrogenase family protein);COG2084;3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase;MmsB;HELO_RS07225;I;;;1.1.1.31;HELO_2317;oxidoreductase (3-hydroxyisobutyrate dehydrogenase family protein);0.9869635276631605;-0.09293902911869045;1.9602725538913828;0.4392899113674731;-0.5476736162956874
HELO_2318;255.5403692470577;179.67372781042604;231.3504502164576;316.65487478821245;356.8432996976481;206.79372422212919;21.427527895002758;18.257018158630927;5.44166878969971;27.645151259160336;12.532166652273567;20.24439764051813;HELO_2318;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS07230;E;;;;HELO_2318;LysE family transport protein;0.5057991307031511;0.16115035762426366;0.78417588402524;0.3040337838134839;-0.20176534688966719
HELO_2319;53.190245875917945;46.08119943715726;44.71067663544235;44.80745095856063;41.70673859275539;44.705655147738206;1.4195064662572707;1.8877477909158697;2.2391250300233514;2.2597558454133986;1.3766955501319844;2.086881720514352;ndpA;nucleoid-associated protein NdpA;COG3081;dsDNA-binding nucleoid-associated protein YejK/NdpA;NdpA;HELO_RS07235;L;ndpA; nucleoid-associated protein NdpA;;ndpA;nucleoid-associated protein NdpA;0.20288211820270163;0.00015849411750856746;-0.09790895341511519;0.24566051246416887;0.042778394261467234
HELO_2320;28.087815128496654;18.04275627054493;23.67464684530024;25.88061397757032;34.23853570487487;25.87578666825546;0.5622164832209359;0.13485444160590962;2.10299426877242;2.2743346725201103;2.232914303427977;1.463655242500782;HELO_2320;ABC-type transport system permease protein;COG0842;ABC-type multidrug transport system, permease component;YadH;HELO_RS07240;V;;ndpA;;HELO_2320;ABC-type transport system permease protein;0.6111726243256337;-0.12327754742856634;0.3908469922857911;0.11410795167790244;-0.49706467264773124
HELO_2321;45.46458021293941;19.088245045926623;48.36936263618929;52.97444222996979;64.96960801704573;52.89334549156877;0.7915033949982812;0.5372254018990824;6.58606787359379;2.442070431538256;7.309384510090589;4.337310941859956;HELO_2321;ABC-type transport system ATP-binding protein;COG1131;ABC-type multidrug transport system, ATPase component;CcmA;HELO_RS07245;V;;;;HELO_2321;ABC-type transport system ATP-binding protein;1.2097798412870109;-0.12649112661552753;0.2916943861647443;-0.21397577267201218;-1.423755613959023
HELO_2322;8.401707978625433;4.1480320704986005;9.965609519256065;19.214619210500274;15.003588008875022;8.34400530554483;1.0621960566936577;0.2329783687443077;3.1796615276750364;3.927436020692473;1.5057490222078074;0.6472634709857741;gfa;probable glutathione-dependent formaldehyde-activating enzyme;COG3791;Uncharacterized conserved protein;;HELO_RS07250;S;gfa; probable glutathione-dependent formaldehyde-activating enzyme;;gfa;probable glutathione-dependent formaldehyde-activating enzyme;0.8689018293671951;0.2308730074023564;0.7762823955099583;0.008881777072670793;-0.8600200522945243
HELO_2323;171.43370266156467;85.83185210399303;159.80786998866083;169.50575059697476;113.92586623761694;161.21789974685888;8.99709310991182;3.0646703120509047;16.74015989875102;22.93039243598477;4.277671594640113;10.331648939236231;nhaD2;sodium/proton antiporter;COG1055;Na+/H+ antiporter NhaD or related arsenite permease;ArsB;HELO_RS07255;P;nhaD2; sodium/proton antiporter;;nhaD2;sodium/proton antiporter;0.989745519226358;-0.012595006655407026;-0.4972294805499491;0.08810876001202939;-0.9016367592143286
HELO_2324;40.10483960703889;9.971152061023654;17.20091083232232;32.76404043150435;32.55005899367588;18.681869267935078;3.425827083249224;0.9233155227166919;1.6647128531562954;2.2892796126515997;1.6435075993120212;0.5060002896764327;HELO_2324;HTH domain protein;COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS07260;K;;nhaD2;;HELO_2324;HTH domain protein;1.9055932356091856;-0.11285659650896207;0.7694480573747979;1.0624410182709827;-0.8431522173382029
HELO_2325;10.687726981040775;4.439350608472546;3.1864068470604696;6.062563567212011;6.850589422824442;3.4380636859654015;0.5270771643442416;0.19346476209037802;0.758484838014793;1.4934730783416972;0.980857588002802;0.2735211772746584;HELO_2325;AhpD domain protein;COG2128;Alkylhydroperoxidase family enzyme, contains CxxC motif;YciW;HELO_RS07265;P;;;;HELO_2325;AhpD domain protein;1.103488056239824;-0.08421784661539977;0.822870605442716;1.3969921076853042;0.2935040514454803
HELO_2326;15.713381931695245;9.789480208475988;18.651365685770074;18.20666523064472;19.650202667357604;17.688078358200077;1.5036171768363575;0.6516161227052152;3.105588631928461;3.761582599473957;2.25150934964742;1.8528528334472987;HELO_2326;DUF399 domain protein;COG3016;Putative heme-binding protein PhuW;PhuW;HELO_RS07270;R;;;;HELO_2326;DUF399 domain protein;0.6313783269008701;0.07251134860266095;0.14403771226816708;-0.16111453803760423;-0.7924928649384744
HELO_2327;54.16183274634733;22.683534783717334;38.23511026529099;43.08874746035621;37.0504238061506;35.556078972696746;5.665263057357017;1.7410826628213383;1.22189366521285;2.0574975994708566;0.9206530910314422;4.71026371908833;HELO_2327;probable S-adenosylmethionine-dependent methyltransferase;;;;;;;;;HELO_2327;probable S-adenosylmethionine-dependent methyltransferase;1.2197859707901735;0.10203392037240633;0.05780118823048408;0.5935590567006006;-0.6262269140895729
HELO_2328;32.869350753303834;7.004978827415145;22.124705354997758;37.668194056311116;38.73712216837424;23.17553411768431;1.4203691209019484;0.9712997228668245;2.538543025964215;1.6382416735300271;4.335314570878151;1.6401067296375467;HELO_2328;YbaK domain protein;COG2606;Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC;EbsC;HELO_RS07280;J;;;3.1.1.-;HELO_2328;YbaK domain protein;2.0810108398220497;-0.06411278042052615;0.7169396299123392;0.4864325678883228;-1.594578271933727
HELO_2329;151.51049489119234;135.930385671778;204.5093107202857;236.15213277496397;203.33405287797282;185.02325453161993;4.123107750560333;3.896947151844441;5.259295255142823;9.43323366443049;17.903784961799307;13.702932780649062;ugd1;UDP-glucose 6-dehydrogenase;COG1004;UDP-glucose 6-dehydrogenase;Ugd;HELO_RS07285;M;ugd1; UDP-glucose 6-dehydrogenase;1.1.1.22;ugd1;UDP-glucose 6-dehydrogenase;0.15546589924721932;0.14372077544756312;0.13544667144118794;-0.28657445805838844;-0.44204035730560776
HELO_2330;75.97132880150016;31.04759750931178;98.44301240648595;94.84490701312846;130.8392878984738;96.37738022949709;1.876821113618479;3.0186705702413983;1.5633865756975762;1.9381929251130676;10.691319068863367;9.887513477186168;HELO_2330;pyridoxal phosphate-dependent aminotransferase;COG0079;Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase;HisC;HELO_RS07290;E;;ugd1;2.6.1.9;HELO_2330;pyridoxal phosphate-dependent aminotransferase;1.2641049462667127;0.030283312406321983;0.43712176222878973;-0.3392655342911137;-1.6033704805578264
HELO_2331;66.3998223924199;25.50790929504363;74.077238842597;75.42621813727719;81.45519322745342;76.43355463743525;2.9451137614956795;0.24608346971502235;3.544518061038903;4.498041897976692;7.119191861697978;4.06772930096782;HELO_2331;FAD-dependent oxidoreductase;COG0277;FAD/FMN-containing lactate dehydrogenase/glycolate oxidase;GlcD;HELO_RS07295;C;;;;HELO_2331;FAD-dependent oxidoreductase;1.3463219018059664;-0.044583279176778845;0.09065148942386703;-0.2002140818056306;-1.546535983611597
HELO_2332;17.06474575779353;9.909223971343513;18.268021837997214;27.428319768828274;19.927291653393368;16.00087366072149;0.9933527175722386;1.09909396369728;0.7760596326648376;2.6147017591759565;0.37855537009555285;1.1202238108325657;HELO_2332;uncharacterized protein;COG3911;Predicted ATPase;;HELO_RS07300;R;;;;HELO_2332;uncharacterized protein;0.7276284714388126;0.18059957699746487;0.299776727295022;0.08756806334192557;-0.640060408096887
HELO_2333;30.646998865909335;14.158634466270252;38.07635838774177;31.085618846659482;38.39581964087453;39.22073808823709;0.7312187541269212;0.7027390668328332;4.509370754732082;4.835085204116677;1.9576937016881473;6.264921104195038;HELO_2333;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS07305;K;;;;HELO_2333;TetR family transcription regulator;1.0619288959157984;-0.04164353106304031;-0.029897005775725738;-0.3458708635649925;-1.407799759480791
HELO_2334;12.691360327837243;6.158023478925838;14.211397804060866;15.660699825520252;19.96509182111912;15.267411294980349;1.21984622256186;0.42761984188459345;1.637289752460103;2.2353269379192207;0.9906459021386462;0.1806946049134057;bcdA;SDR family cyclic-diguanylate-sequestering protein BcdA;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS07310;I;bcdA; SDR family cyclic-diguanylate-sequestering protein BcdA;1.1.1.100;bcdA;SDR family cyclic-diguanylate-sequestering protein BcdA;0.9356326140412103;-0.09683195571605552;0.36600446194983594;-0.24871889176251516;-1.1843515058037255
HELO_2335;18.600896171332703;9.149370071786882;18.29483466918796;21.27296045846919;22.451342515156906;19.829088289243984;1.995402720051527;2.0434229219699205;3.5375208821985633;0.8951223159355272;0.8692577896821025;2.7959711137737093;HELO_2335;DUF1486 family protein;COG3631;Ketosteroid isomerase-related protein;YesE;HELO_RS07315;R;;bcdA;;HELO_2335;DUF1486 family protein;0.9495294289702518;-0.11038501053140504;0.1710708223258397;-0.08768007528813193;-1.0372095042583838
HELO_2336;86.39880666529302;6.912264441471102;32.348758611132844;32.96377912288595;21.681630141029625;22.56552862056161;5.002569673814919;0.5661523042842591;3.293472151424576;5.124567457182142;2.4348088191846733;5.713352468113535;HELO_2336;DjlA domain protein;COG4103;Tellurite resistance protein TerB;TerB2;HELO_RS07320;P;;;;HELO_2336;DjlA domain protein;3.465451032081927;0.5009550147271122;-0.055153712887662465;1.8909355372770724;-1.5745154948048548
HELO_2337;267.7284717938196;85.61152864364543;206.67955938783822;223.32934442270903;205.30539288733164;182.67336831257094;11.715570372771174;5.711375960298015;6.575204861976274;4.317198016041228;23.522800767948915;11.708164138500832;HELO_2337;FAD-dependent oxidoreductase;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS07325;E;;;1.4.5.1;HELO_2337;FAD-dependent oxidoreductase;1.633518206684573;0.17721676933490738;0.16763907591403626;0.5490067247526023;-1.0845114819319708
HELO_2338;162.17643397409233;63.56218519434248;79.45420291802701;90.03993106309163;106.0658211704324;78.47172438320644;11.982268775353647;10.357533645360196;0.48324893392318674;4.615229294523669;7.964018080034793;4.952120508494964;HELO_2338;uncharacterized protein;;;;;;;;;HELO_2338;uncharacterized protein;1.3376714030646495;0.017726140665993206;0.42998444566877314;1.0379191639992467;-0.2997522390654028
HELO_2340;226.35398973922258;168.5649764010945;261.46988028435163;296.90667923850134;277.3341540988286;251.78879692596263;7.896288707677388;4.159188227774816;11.083580408269928;4.4934834912644375;22.268064122334945;17.250064612519974;pyrC;dihydroorotase;COG0418;Dihydroorotase;PyrC;HELO_RS07335;F;pyrC; dihydroorotase;3.5.2.3;pyrC;dihydroorotase;0.4231021091405438;0.05421934820651497;0.1388854234758652;-0.152992206135254;-0.5760943152757978
HELO_2341;440.90708723306557;585.8061425636066;340.8444934747559;366.21491017929765;372.79656902131245;353.22704734480675;30.121144837171894;43.307629599478;14.842620921392816;13.737867114771;11.33587069375397;10.588238558784504;pfs;5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase;COG0775;Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB;MtnN;HELO_RS07340;FH;pfs; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase;3.2.2.9;pfs;5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase;-0.40914090393354385;-0.05133418847208482;0.07757895237750745;0.3190686943312677;0.7282095982648116
HELO_2343;398.10874625446075;431.3824040270165;456.2943200501172;604.4409493823902;490.43567050230445;437.80315429602575;6.424337263428686;15.68521717478354;11.573080971620495;26.121899893864395;9.398790421230244;36.64982131384057;luxS;S-ribosylhomocysteine lyase;COG1854;S-ribosylhomocysteine lyase LuxS, autoinducer biosynthesis;LuxS;HELO_RS07345;T;luxS; S-ribosylhomocysteine lyase;4.4.1.21;luxS;S-ribosylhomocysteine lyase;-0.11552591813683932;0.059549103406892456;0.16342868201688532;-0.13679200137379155;-0.021266083236952227
HELO_2344;176.29676816747238;105.27047646326707;161.8307236407486;156.1034099173177;179.97035311450693;175.46647702946336;6.678551747904013;7.846192288278855;2.516890411665472;5.13975947787993;7.171078864553593;14.526014974393146;folD;bifunctional protein FolD;COG0190;5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase;FolD;HELO_RS07350;H;folD; bifunctional protein FolD;1.5.1.5,3.5.4.9;folD;bifunctional protein FolD;0.7384253883337637;-0.1160212041973514;0.03635922805387359;0.006772094744412094;-0.7316532935893516
HELO_2345;660.0935509990173;601.5396547929539;1696.4698148816371;1926.855972088222;1537.961156616905;1690.547088644662;32.62914962598738;19.584403528550144;184.72471120140344;12.138141906193551;263.32579753753316;169.081131065197;tig;trigger factor;COG0544;FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor);Tig;HELO_RS07375;O;tig; trigger factor;;tig;trigger factor;0.13379824899378612;0.005042581204468988;-0.13638652038734556;-1.3554169925822048;-1.489215241575991
HELO_2346;694.8551912696033;959.748752815035;828.8286110826647;972.7544095972213;770.1335698009449;908.0182606619064;43.93916561169006;71.03749602161461;37.48463519647683;51.63897679727456;20.69187145955775;66.79424094702982;clpP;ATP-dependent Clp protease proteolytic subunit;COG0740;ATP-dependent protease ClpP, protease subunit;ClpP;HELO_RS07380;O;clpP; ATP-dependent Clp protease proteolytic subunit;3.4.21.92;clpP;ATP-dependent Clp protease proteolytic subunit;-0.4653720886235657;-0.13149587630499404;-0.2373285017724367;-0.38552216620176516;0.07984992242180056
HELO_2347;897.3381238421503;848.330665060088;1098.5814229320995;1221.0971473278628;933.0237997208359;1069.71631154271;45.77935404503232;55.834146570877984;38.645651339959045;6.774342965145505;53.35602711127172;55.433462862758894;clpX;ATP-dependent Clp protease ATP-binding subunit ClpX;COG1219;ATP-dependent protease Clp, ATPase subunit ClpX;ClpX;HELO_RS07385;O;clpX; ATP-dependent Clp protease ATP-binding subunit ClpX;;clpX;ATP-dependent Clp protease ATP-binding subunit ClpX;0.08093222116018772;0.038378152567515755;-0.1970450691291763;-0.25324582009941565;-0.3341780412596034
HELO_2348;414.52529945796783;399.0223197852668;627.5559435197399;921.342084201794;479.4385255387776;594.9192186674787;33.40005851955145;12.536742288370563;32.13124203339292;72.08258143444306;43.6837006745747;63.401919836399216;lon1;ATP-dependent protease Lon;COG0466;ATP-dependent Lon protease, bacterial type;Lon;HELO_RS07390;O;lon1; ATP-dependent protease Lon;3.4.21.53;lon1;ATP-dependent protease Lon;0.054855819489231905;0.07692437912600703;-0.31076493286166595;-0.5201804569249031;-0.575036276414135
HELO_2349;5475.028665038238;4257.886042641121;3090.3044489802446;2102.525618328662;1534.95292273872;1517.1670943281777;615.6770049802275;353.08475627847093;789.4328420900328;1109.1341540751237;442.03698807278715;267.3486435351515;hupB1;HU-type DNA-binding protein HupB;COG0776;Bacterial nucleoid DNA-binding protein IHF-alpha;HimA;HELO_RS07395;L;hupB1; HU-type DNA-binding protein HupB;;hupB1;HU-type DNA-binding protein HupB;0.36265387118551295;1.025885158758296;0.016803410723142065;1.8507994114797857;1.4881455402942727
HELO_2350;445.37344747427034;455.7995079267484;471.8244977158479;505.00606324941054;384.11003565919424;480.30897332952026;17.755406819459797;18.47981948496295;21.63926565211855;10.094799164470457;17.509538169321935;2.6659457490796385;HELO_2350;PpiC-type peptidyl-prolyl cis-trans isomerase;COG0760;Peptidyl-prolyl isomerase, parvulin family;SurA;HELO_RS07400;O;;hupB1;5.2.1.8;HELO_2350;PpiC-type peptidyl-prolyl cis-trans isomerase;-0.03330988560157877;-0.02565853502281179;-0.3216926014729786;-0.10871210957436794;-0.07540222397278917
HELO_2351;42.863084685214886;38.68476235326619;43.95178120923694;70.56378672199676;46.185651545283775;41.95790258101502;2.589949216926999;3.8919302239688895;2.284854195402158;2.8050810320041943;4.210792977532741;0.7228415766558748;HELO_2351;CobW family protein;COG0523;Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family;YejR;HELO_RS07405;R;;;;HELO_2351;CobW family protein;0.14442210743406836;0.06545472802194574;0.13542466869618508;0.030083718083396604;-0.11433838935067175
HELO_2352;36.31269349129326;34.507106569317614;20.899795575094245;31.504338391627403;24.162348413114245;21.894002726152028;3.8566505299492766;0.29253351591734034;2.158139195656725;3.116578492087908;1.2173753756024859;1.0982255370522123;HELO_2352;uncharacterized protein;;;;;;;;;HELO_2352;uncharacterized protein;0.07155870604189918;-0.06405231891622964;0.13629685398223845;0.7046967858509765;0.6331380798090773
HELO_2353;23.7049556462525;19.385306038685275;14.443677215318578;23.041446207240984;17.148365977863786;14.132512141870237;1.0127145755241267;0.9053026580924722;0.9048496743144117;0.78647584394177;0.805896236767628;1.5027442837180678;HELO_2353;MetF family protein;COG0685;5,10-methylenetetrahydrofolate reductase;MetF;HELO_RS07415;E;;;1.5.1.20;HELO_2353;MetF family protein;0.27727084991128503;0.029364797652810193;0.2621881496936722;0.7071489570389535;0.4298781071276685
HELO_2354;501.3483355413626;268.3632266927877;349.72811267835056;357.1800273440274;403.7750357663028;392.15736672869525;32.71368396240495;11.956892533693447;17.884889788399892;26.66244531124304;31.99919257794743;26.104536784440235;lpxH;UDP-2%2C3-diacylglucosamine hydrolase;COG2908;UDP-2,3-diacylglucosamine pyrophosphatase LpxH;LpxH;HELO_RS07420;M;lpxH; UDP-2,3-diacylglucosamine hydrolase;3.6.1.54;lpxH;UDP-2%2C3-diacylglucosamine hydrolase;0.8991351882363414;-0.16475381220822705;0.042013428581391565;0.3535812096838953;-0.5455539785524461
HELO_2355;447.5123674028493;258.43834432289617;443.58795026610204;448.7812954003286;429.6841135074758;463.38662599688496;31.358647917099688;7.709846589815993;25.01657447824576;19.28184487187003;9.707765219148392;22.615690102680535;ppiB;CLD peptidyl-prolyl cis-trans isomerase PpiB;COG0652;Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family;PpiB;HELO_RS07425;O;ppiB; CLD peptidyl-prolyl cis-trans isomerase PpiB;5.2.1.8;ppiB;CLD peptidyl-prolyl cis-trans isomerase PpiB;0.7897560449803827;-0.06285757690039517;-0.10869631583543438;-0.05017865725392667;-0.8399347022343093
HELO_2356;222.16535946431398;114.5571142656542;372.1035505935622;336.711645426168;385.40969181461213;377.49680894810166;0.6891893322132123;2.502036555056298;32.49008529307442;22.002296835435594;42.206285858890524;36.054082348481366;glnS;glutamine--tRNA ligase;COG0008;Glutamyl- or glutaminyl-tRNA synthetase;GlnS;HELO_RS07430;J;glnS; glutamine--tRNA ligase;6.1.1.18;glnS;glutamine--tRNA ligase;0.9495070222352036;-0.020705047660831255;0.029850142772691157;-0.7621680329146914;-1.711675055149895
HELO_2357;88.94346380564018;54.0650617563399;306.37913722355245;267.9689745925718;291.12532620188716;318.11170428265126;7.680828153294169;4.067872636399019;19.14562528881325;8.560411155593044;20.49311770521904;7.773098565616209;cysS;cysteine--tRNA ligase;COG0215;Cysteinyl-tRNA synthetase;CysS;HELO_RS07435;J;cysS; cysteine--tRNA ligase;6.1.1.16;cysS;cysteine--tRNA ligase;0.707881211426816;-0.05404227616070578;-0.12747408432524132;-1.8269711746160162;-2.5348523860428323
HELO_2358;18.80383028154566;3.161007224800254;25.362657744379785;56.7949786515427;42.12614176617218;19.454185088199946;0.6909364327389664;0.4436249497808031;2.0309215439335158;3.659717651926703;20.02721853799129;2.5902035865371698;HELO_2358;uncharacterized protein;;;;;;;;;HELO_2358;uncharacterized protein;2.2507747921322947;0.3660997624008129;1.0761665924907202;-0.046616569600533175;-2.297391361732828
HELO_2359;15.942509217869238;17.527482130387753;12.455273387236678;10.998430871987502;10.949284904569595;13.377639477073913;1.8307577414677363;1.7878009113255433;0.44767091673018244;1.7389111088971778;0.6869677694230116;1.1081145743360825;HELO_2359;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS07450;K;;;;HELO_2359;TetR family transcription regulator;-0.1290192772385952;-0.09565512906411655;-0.26690254948434644;0.23682072303701052;0.3658400002756057
HELO_2360;13.863879992970057;27.895656235277883;30.503396402162895;21.013482945848335;25.195546146414213;34.67735145282503;1.5244929775482512;0.36805726064897776;1.1759615288082212;1.1397739475547104;3.843276822069468;3.378912695954347;HELO_2360;amidinotransferase domain protein;COG1834;N-Dimethylarginine dimethylaminohydrolase;DdaH;HELO_RS07455;E;;;3.5.3.18;HELO_2360;amidinotransferase domain protein;-0.9590418756925048;-0.17950114427897734;-0.4456869783702677;-1.2631977602477575;-0.3041558845552528
HELO_2361;24.271282091296445;28.14481327681753;32.76776014456264;27.024596948781863;24.519664875044665;32.409922250611736;2.6137993469326988;1.4069607734936356;2.0584929433564443;1.6556205442245813;0.8331303646273303;4.432702978862311;HELO_2361;ABC-type transport system ATP-binding protein;COG1126;ABC-type polar amino acid transport system, ATPase component;GlnQ;HELO_RS07460;E;;;7.4.2.1;HELO_2361;ABC-type transport system ATP-binding protein;-0.20574030012719735;0.015369861520855288;-0.3886672416157353;-0.40277776675345134;-0.197037466626254
HELO_2362;25.680163501044024;27.28310909821316;41.37871969102117;30.70000087257544;38.22163997182684;42.20752285371563;1.8132936096758083;0.5071890476371089;1.33101383019853;0.8149291359997285;1.2615197726027778;3.2517259801488825;HELO_2362;ABC-type transport system periplasmic substrate-binding protein;COG0834;ABC-type amino acid transport/signal transduction system, periplasmic component/domain;HisJ;HELO_RS07465;TE;;;;HELO_2362;ABC-type transport system periplasmic substrate-binding protein;-0.08417321341230544;-0.02794251869979547;-0.13963266151871423;-0.6955150139665918;-0.6113418005542863
HELO_2363;20.60004997463504;26.533782460935594;23.07866135923472;17.774672927659307;19.13640638186216;23.46002536751303;0.4202221374827173;1.6654985454617617;2.5210593591885164;1.973360953814874;0.2833782835088472;0.918138641996161;HELO_2363;ABC-type transport system permease protein;COG4215;ABC-type arginine transport system, permease component;ArtQ;HELO_RS07470;E;;;;HELO_2363;ABC-type transport system permease protein;-0.350168163913283;-0.022670711646353148;-0.28061966250433557;-0.17939124982375;0.170776914089533
HELO_2364;13.25783025013149;16.61089268151106;18.44734706813676;18.82178576462353;19.867526683667602;21.65967834787162;0.4966230298093598;0.8939327401714906;1.3012803102759933;0.4134110710721538;1.852559877586519;2.5021558518132094;HELO_2364;ABC-type transport system permease protein;COG4160;ABC-type arginine/histidine transport system, permease component;ArtM;HELO_RS07475;E;;;;HELO_2364;ABC-type transport system permease protein;-0.3047135901989204;-0.2205540206183354;-0.11886776667212562;-0.6683729325392953;-0.3636593423403749
HELO_2365;15.757554058035979;8.158438995497578;13.808654684933089;16.706761360064274;15.155187501875488;12.938797007686782;1.8170562667623291;0.23132188396432393;3.0664274270008667;1.6748563672461692;1.9413284898396335;1.7461596850945864;HELO_2365;DUF1853 domain protein;COG3782;Uncharacterized conserved protein, DUF1853 domain;;HELO_RS07480;S;;;;HELO_2365;DUF1853 domain protein;0.8716379627090141;0.08733452840013456;0.21289144072073451;0.2657055335042644;-0.6059324292047497
HELO_2366;92.9267960281308;69.11005531405621;103.71434028323047;132.74292976661732;130.25882282254057;102.72403094208039;3.309245303259827;2.667024484096891;11.1559326645499;12.60022276232783;6.0729745740118135;4.927713850070178;osmX;ABC-type transport system periplasmic substrate-binding protein (probable substrate osmolyte);COG1732;Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein);OsmF;HELO_RS07485;M;osmX; ABC-type transport system periplasmic substrate-binding protein (probable substrate osmolyte);;osmX;ABC-type transport system periplasmic substrate-binding protein (probable substrate osmolyte);0.4219154246584358;0.013708849452450877;0.33966422098200777;-0.14314147582667847;-0.5650569004851143
HELO_2367;68.42762260855305;43.22083265386599;47.18035381263264;63.55080992108006;64.54548885896908;50.54220741700152;4.967556655643587;2.2035839186471002;3.187587856001479;2.9851577463006955;1.1842759046863853;1.4423964566075473;osmW;ABC-type transport system permease protein (probable substrate osmolyte);COG1174;ABC-type proline/glycine betaine transport system, permease component;OpuBB;HELO_RS07490;E;osmW; ABC-type transport system permease protein (probable substrate osmolyte);;osmW;ABC-type transport system permease protein (probable substrate osmolyte);0.6507835799042478;-0.09730933729731905;0.34674216562738636;0.4297554451155401;-0.22102813478870775
HELO_2368;52.17028047500895;32.150882663585634;30.247749697515378;40.3332929931093;37.32007545119912;27.335900127712293;1.3034002251452907;1.7151232187877463;1.31552221441745;2.4844852635242143;0.1738421392367144;2.3018115837453945;osmV;ABC-type transport system ATP-binding protein (probable substrate osmolyte);COG1125;ABC-type proline/glycine betaine transport system, ATPase component;OpuBA;HELO_RS07495;E;osmV; ABC-type transport system ATP-binding protein (probable substrate osmolyte);7.6.2.9;osmV;ABC-type transport system ATP-binding protein (probable substrate osmolyte);0.6815727931722657;0.14112126571638406;0.4354693693945002;0.9079890443952809;0.22641625122301523
HELO_2369;28.197762902403582;18.270191233217133;17.10774892347317;18.580207018804817;20.328402390611746;14.44461683535998;1.145922309751178;3.21663132786721;0.8116594174146364;3.0952734920616796;0.8709256218948302;2.003226065311586;osmY;ABC-type transport system permease protein (probable substrate osmolyte);COG1174;ABC-type proline/glycine betaine transport system, permease component;OpuBB;HELO_RS07500;E;osmY; ABC-type transport system permease protein (probable substrate osmolyte);;osmY;ABC-type transport system permease protein (probable substrate osmolyte);0.5994869470761568;0.22950312819891394;0.46567182461933054;0.9187537561064252;0.3192668090302684
HELO_2370;17.64202556561565;12.665645459533378;22.567671972424847;44.890422113689624;25.09664165673819;23.617464407742812;0.8663777221955904;1.699096113273943;4.843304592821554;8.378029478782539;3.530831921023627;1.0307895699889569;bkdA1;branched-chain alpha-keto acid dehydrogenase component E1 alpha subunit;COG1071;TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha;AcoA;HELO_RS07505;C;bkdA1; branched-chain alpha-keto acid dehydrogenase component E1 alpha subunit;1.2.4.4;bkdA1;branched-chain alpha-keto acid dehydrogenase component E1 alpha subunit;0.4480050225621022;-0.0628729168526867;0.08418198789950715;-0.40112354646842174;-0.8491285690305239
HELO_2371;14.087091405015562;8.766845590807948;14.189894019858835;30.332302397403243;18.201435927980743;15.085405124673855;0.9046282705867743;0.913315811112507;1.7142702062594561;3.7677336539248496;0.9504628662321262;1.4785524296694776;bkdA2;branched-chain alpha-keto acid dehydrogenase component E1 beta subunit;COG0022;Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component, beta subunit;AcoB;HELO_RS07510;C;bkdA2; branched-chain alpha-keto acid dehydrogenase component E1 beta subunit;1.2.4.4;bkdA2;branched-chain alpha-keto acid dehydrogenase component E1 beta subunit;0.6273501061513245;-0.0826404677876802;0.2554619311113244;-0.09243757212302928;-0.7197876782743537
HELO_2372;22.860048332572877;13.364654611015098;18.44725042488611;33.94511071670732;27.57025995467774;19.069080724038255;0.6437658488422773;0.736019773499482;0.7657077419908342;5.616894576750682;2.995781046145701;0.7774094576948603;bkdB;branched-chain alpha-keto acid dehydrogenase component E2;COG0508;Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component;AceF;HELO_RS07515;C;bkdB; branched-chain alpha-keto acid dehydrogenase component E2;2.3.1.168;bkdB;branched-chain alpha-keto acid dehydrogenase component E2;0.7320736608567961;-0.045408342433696625;0.5095396283820834;0.2496224307343038;-0.48245123012249236
HELO_2373;36.21675165680682;29.525418880626063;14.266303673840829;22.5740553338577;20.45178117566224;14.07286757704072;3.3978317471018795;2.7048730746470167;1.6275572457788028;3.619517053762806;7.070376160076282;2.11409213490608;HELO_2373;HTH domain protein;COG3093;Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain;VapI;HELO_RS07520;V;;bkdB;;HELO_2373;HTH domain protein;0.28594104742333837;0.018396882157224237;0.5091435296404305;1.3039982276130657;1.0180571801897274
HELO_2374;7.559492494170647;4.628202007165346;3.7292699369375932;6.4746510832998645;6.549553103032335;3.660209080519362;0.26099734857536205;0.48230932125988046;0.25844030844050014;0.42426676473329916;0.9501804677990564;0.44470123987639304;HELO_2374;protein kinase domain protein;COG0515;Serine/threonine protein kinase;SPS1;HELO_RS07525;T;;;2.7.11.1;HELO_2374;protein kinase domain protein;0.6048511488473487;0.021222807273615807;0.6959965634898397;0.8771305765759929;0.2722794277286442
HELO_2375;63.211349815874485;8.822626314678578;22.38117937160568;22.341978764465917;23.355802608189624;23.550788571483917;3.323452214272543;0.5411950876367894;1.7960454333904214;2.146253231284827;1.6458524940638009;2.6173559979455705;HELO_2375;FAD-dependent oxidoreductase;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS07530;E;;;;HELO_2375;FAD-dependent oxidoreductase;2.708647606223298;-0.07042166187766519;-0.011503838889797002;1.3870589619084468;-1.321588644314851
HELO_2376;82.89484613700722;99.21465051554026;112.80254960659177;113.59160015552635;108.55001611999371;116.73361583153502;2.347035534859229;2.836040763038414;2.9442017343457527;1.562858045569592;5.17685043415209;6.840029383890855;HELO_2376;DUF3584 family protein;COG1196;Chromosome segregation ATPase Smc;Smc;HELO_RS07535;D;;;;HELO_2376;DUF3584 family protein;-0.256439343234268;-0.048993424151813514;-0.10393660735500454;-0.488872213712221;-0.23243287047795302
HELO_2377;65.2098777561096;84.07087458826322;56.33747381300347;55.22918347921925;53.58605910089178;62.64336995526012;2.4904886248069147;5.569579901764216;1.2157765004979972;7.056801851539813;2.21104437824817;3.9760326821618936;HELO_2377;uncharacterized protein;;;;;;;;;HELO_2377;uncharacterized protein;-0.361618819411623;-0.15053188586984945;-0.22147768534644285;0.05703623740641639;0.4186550568180394
HELO_2378;71.60581621857281;88.48261722974395;85.45419341055953;95.93134630257327;85.1405197121262;92.32324735255933;1.033943209242829;4.794851623662296;3.2210992634469298;0.9685682423630013;4.727893035574853;4.136810073978511;HELO_2378;uncharacterized protein;;;;;;;;;HELO_2378;uncharacterized protein;-0.3015223311253976;-0.11030056674837763;-0.11554448157327091;-0.36215138688719595;-0.060629055761798334
HELO_2379;94.14546549809991;77.28686932269518;92.51539401177733;92.87995235451267;100.6502977360954;97.83977594260075;4.8047075503661425;1.6808112556582777;4.107952919108881;3.7686457901558224;1.3075414796413545;5.1661353055039045;HELO_2379;UPF0271 family protein;COG1540;5-oxoprolinase subunit A;PxpA;HELO_RS07550;E;;;3.5.2.9;HELO_2379;UPF0271 family protein;0.28136454972095937;-0.07988786685040594;0.04045079550231101;-0.0549568389831796;-0.33632138870413897
HELO_2380;120.19774564915126;103.51514221608875;117.97935441134643;125.66942120238143;128.57343153819212;118.02957057392736;1.6648237523531515;3.2078126279482286;4.572637289618971;4.2814314487267415;1.9899597559254936;5.710783571484022;HELO_2380;uncharacterized protein;COG2049;5-oxoprolinase subunit B/Allophanate hydrolase subunit 1;PxpB;HELO_RS07555;E;;;;HELO_2380;uncharacterized protein;0.21365088810006583;-0.0006087722114411775;0.12244990278954138;0.02604283657734552;-0.1876080515227203
HELO_2381;68.60782675993734;58.284124475808085;93.0556910051818;100.44232538088932;106.88130116111786;84.50411055024453;3.610718710003456;7.08086303459091;5.307708492789855;5.0413523944273955;3.925103784738862;3.3032870325606813;HELO_2381;uncharacterized protein;COG1984;5-oxoprolinase subunit C/Allophanate hydrolase subunit 2;PxpC;HELO_RS07560;E;;;3.5.2.9;HELO_2381;uncharacterized protein;0.23160371162518167;0.13752146097334883;0.3353791438671525;-0.29674424523608955;-0.5283479568612712
HELO_2382;53.02722231471907;29.426618335402594;21.85852189728403;29.76452344757345;21.58830794819475;21.51272157620828;3.8479085555758825;2.676901111529324;2.0534159730664903;1.9180756644870165;1.7433455130572324;0.929043882901961;HELO_2382;CopG domain protein;;;;;;;;;HELO_2382;CopG domain protein;0.8283525117736392;0.021991641854872235;0.004835729351204243;1.2629460354364301;0.4345935236627909
HELO_2383;77.32311176485642;37.92709273393124;63.6898471382861;66.11277495505588;71.38519559158819;61.17726693967777;7.277914254942643;2.8160363180383694;1.3199933895860652;3.050991328994598;8.447965303565923;5.388981418511836;csiR;GntR family transcription regulator CsiR;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS07570;K;csiR; GntR family transcription regulator CsiR;;csiR;GntR family transcription regulator CsiR;1.008663482954117;0.057152100622945845;0.21930746068351592;0.33305088107277925;-0.6756126018813378
HELO_2384;4.708524513163743;0.7598642772802519;2.158881165668927;2.4380511949437653;2.291074819294934;2.1993904634877075;0.3031737702640459;0.23007311749177273;0.44802450375440184;0.39132328957144863;0.3273077628594925;0.4980942591818511;HELO_2384;phoD family phosphatase;COG3540;Phosphodiesterase/alkaline phosphatase D;PhoD;HELO_RS07575;P;;csiR;3.1.3.1;HELO_2384;phoD family phosphatase;1.6976537283626523;-0.018383408967444836;0.04076175090960876;0.8353208250906177;-0.8623329032720346
HELO_2385;204.72670027263283;71.90208842462366;189.37901273647307;257.4625926460171;129.68509776193878;160.50875793297084;6.951020323051839;3.195999539712777;10.41474931185436;4.645396743936496;28.87443729430388;53.38594888813676;HELO_2385;CitM family transport protein;COG0471;Di- and tricarboxylate antiporter;CitT;HELO_RS07580;G;;;;HELO_2385;CitM family transport protein;1.4966969973086561;0.23726204735482437;-0.3055177606475432;0.3491166481646113;-1.1475803491440448
HELO_2386;490.83652831772906;192.94222550359925;1107.0197142233792;1066.1148992042038;738.3167812305304;841.7098677639406;46.790832906508655;8.147581504467817;83.56419724392634;21.122124541749134;228.72018237266138;273.38210196077273;cysQ;3'(2')%2C5'-bisphosphate nucleotidase CysQ;COG1218;3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase;CysQ;HELO_RS07585;P;cysQ; 3'(2'),5'-bisphosphate nucleotidase CysQ;3.1.3.7;cysQ;3'(2')%2C5'-bisphosphate nucleotidase CysQ;1.3425519425552377;0.39487562675903654;-0.18884335818529863;-0.7768571318567314;-2.119409074411969
HELO_2387;839.6156738255772;473.3006567963169;2424.2855701609114;2205.781801849887;1981.5301801551225;2120.613952599775;98.86032048321195;28.774649790699886;165.87121309606644;189.78433912493108;570.0690040193076;596.8749468779789;cysD2;sulfate adenylyltransferase subunit 2;COG0175;Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme;CysH;HELO_RS07590;EH;cysD2; sulfate adenylyltransferase subunit 2;2.7.7.4;cysD2;sulfate adenylyltransferase subunit 2;0.8256444905107756;0.19299246200467834;-0.09781934003160941;-1.335643906506096;-2.1612883970168717
HELO_2388;1559.5181654738283;1025.6652856182898;1351.1947486564586;1050.5904787422733;927.1685986636222;1128.0948388258757;126.79981602500966;96.59033368967434;90.34315554025537;52.916375701985935;145.04329158314417;314.71066725136575;HELO_2388;uncharacterized protein;;;;;;;;;HELO_2388;uncharacterized protein;0.6040592417712833;0.26013627845010845;-0.28270787610714443;0.46685848027327204;-0.1372007614980113
HELO_2389;616.801270071884;345.10523409991066;1768.1336342477618;1481.0304243190021;1426.5018836643558;1568.9670720750194;66.73341778311669;18.165631927169347;33.089253379240944;137.6141614467644;407.667728509091;499.8940055185071;cysNC2;sulfate adenylyltransferase subunit 1 / adenylyl-sulfate kinase;COG2895;Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family;CysN;HELO_RS07600;P;cysNC2; sulfate adenylyltransferase subunit 1 / adenylyl-sulfate kinase;2.7.7.4,2.7.1.25;cysNC2;sulfate adenylyltransferase subunit 1 / adenylyl-sulfate kinase;0.8359320775128829;0.17230872748062964;-0.13724165156515689;-1.345519558902625;-2.181451636415508
HELO_2390;361.9580675480933;165.19541342373216;772.9743661999188;690.2377988903941;692.1347673551012;677.2476929378284;33.14418667767765;11.683050588335137;57.71399351661645;70.7962186531624;204.01168931298164;224.95164209195428;HELO_2390;uncharacterized protein;;;;;;;;;HELO_2390;uncharacterized protein;1.1269223157667065;0.19047355034893876;0.031323650068916464;-0.9020093515203662;-2.0289316672870727
HELO_2391;319.60658205690623;146.31839876079178;760.2979063626594;764.6926342707694;550.0765107628843;627.188778111039;35.72120957032852;11.894591608213673;24.72823455886038;25.702494811367945;144.18997916765008;171.485577967773;kpsD;polysaccharide export protein KpsD;COG1596;Periplasmic protein Wza involved in polysaccharide export, contains SLBB domain of the beta-grasp fold;Wza;HELO_RS07610;M;kpsD; polysaccharide export protein KpsD;;kpsD;polysaccharide export protein KpsD;1.1218664229075417;0.27726293957823245;-0.1889455364391548;-0.9703941267462728;-2.0922605496538145
HELO_2392;464.9482928244533;349.5111126858158;683.9615842292382;886.3091298768935;560.1867291484831;638.7476903388919;36.886263902982044;17.32549375879935;34.951901015566904;63.83826624333997;81.50573284237275;120.9223032201034;HELO_2392;ABC-type transport system permease protein;COG1682;ABC-type polysaccharide/teichoic acid/polyol phosphate export permease;TagG;HELO_RS07615;G;;kpsD;;HELO_2392;ABC-type transport system permease protein;0.410709680626951;0.09852004366464229;-0.18902214101123427;-0.4573331686303135;-0.8680428492572645
HELO_2393;479.7011600889607;326.14215836327;623.7610825166884;738.2178495753002;429.78146659387465;570.5856082654623;22.67811954718995;15.736247561752982;22.007016971652536;7.49995648945714;82.28757140290412;110.59642837892352;HELO_2393;ABC-type transport system ATP-binding protein;COG1134;ABC-type polysaccharide/polyol phosphate transport system, ATPase component;TagH;HELO_RS07620;G;;;7.6.2.12;HELO_2393;ABC-type transport system ATP-binding protein;0.5552225956332215;0.128334996402236;-0.4080134093267258;-0.24982930665207803;-0.8050519022852995
HELO_2394;557.8679649507045;339.48433830174616;693.9579747503184;800.5557220473587;450.5973981823319;627.3722172242971;21.375705579271997;9.249301337233472;67.05226883289333;22.77590896128727;93.9840673894482;88.16661928237198;HELO_2394;homolog to capsule polysaccharide export inner-membrane protein;COG3524;Capsule polysaccharide export protein KpsE/RkpR;KpsE;HELO_RS07625;M;;;;HELO_2394;homolog to capsule polysaccharide export inner-membrane protein;0.7149190419323013;0.14530634344376558;-0.4765822206510144;-0.16911191470535414;-0.8840309566376554
HELO_2395;528.2837647856164;244.07869069176556;433.6913257876019;531.1862735820636;271.8871071952001;341.65247312638866;8.803609633059123;3.8689051459994417;38.12685121790926;93.2122940508025;52.652952785015735;77.1124344021284;HELO_2395;glycosyltransferase domain protein;COG4092;Predicted glycosyltransferase involved in capsule biosynthesis;;HELO_RS07630;M;;;;HELO_2395;glycosyltransferase domain protein;1.1107963525259885;0.34324520727595065;-0.32844186506847706;0.6272953016977585;-0.48350105082823003
HELO_2396;344.8755452870151;145.28723015496269;431.27661261798477;669.4825391659466;259.9015834926718;290.5095133169064;15.747226183623503;1.647318354045577;60.594012083697635;98.6433028868889;91.01706570448627;109.05907778538132;rffG;dTDP-glucose 4%2C6-dehydratase;COG1088;dTDP-D-glucose 4,6-dehydratase;RfbB;HELO_RS07640;M;rffG; dTDP-glucose 4,6-dehydratase;4.2.1.46;rffG;dTDP-glucose 4%2C6-dehydratase;1.2414491754498744;0.5684118184096381;-0.1600372657254603;0.24671004723377088;-0.9947391282161036
HELO_2397;395.2070649795978;160.03529798443319;690.2276523326364;835.3813578328269;504.7948255876554;541.4656689548948;22.287359802358733;6.47876122846046;63.71129690204398;26.3931235812106;185.7699638829305;156.90711179670132;rmlA;glucose-1-phosphate thymidylyltransferase;COG1209;dTDP-glucose pyrophosphorylase;RmlA1;HELO_RS07645;M;rmlA; glucose-1-phosphate thymidylyltransferase;2.7.7.24;rmlA;glucose-1-phosphate thymidylyltransferase;1.298877652702843;0.34962909664065656;-0.10097955861916574;-0.4532772306292099;-1.7521548833320528
HELO_2398;441.4342823581881;343.91107854425104;1059.2245514588533;679.4443914729371;809.3615013152648;824.3133668511952;40.21023373470273;28.709115895815238;60.893485612176455;29.221091348004393;207.2114173761153;224.530829908498;galE2;UDP-glucose 4-epimerase;COG1087;UDP-glucose 4-epimerase;GalE;HELO_RS07685;M;galE2; UDP-glucose 4-epimerase;5.1.3.2;galE2;UDP-glucose 4-epimerase;0.35923870932124125;0.36135594268130333;-0.02637637042933605;-0.8994788283554147;-1.258717537676656
HELO_2399;264.60724492066055;209.70499003297732;609.8333532146476;511.6156151284934;455.6491215842481;510.51534345221654;22.481672738501512;13.652724494150661;58.99117753919972;5.379995573689211;81.08866548837807;124.09720547008675;HELO_2399;LipA family protein;COG3563;Capsule polysaccharide export protein KpsC/LpsZ;KpsC;HELO_RS07690;M;;galE2;;HELO_2399;LipA family protein;0.3340700180849714;0.2560013236747096;-0.16369145770262428;-0.9454830164546184;-1.2795530345395898
HELO_2400;100.45848172519239;42.990697160856236;129.01629220464682;122.49874402650455;87.13666745031158;103.74733923088536;7.188941537350382;4.615870206232845;15.839857042661242;1.8406450788854563;15.730443634764933;30.27801200107965;HELO_2400;phytanoyl-CoA dioxygenase domain protein;;;;;;;;;HELO_2400;phytanoyl-CoA dioxygenase domain protein;1.2056191062913095;0.31177881981306577;-0.24909934457925864;-0.046024120822202086;-1.2516432271135116
HELO_2401;190.6001121482087;90.40997675241503;285.59927353123214;258.0617815659055;253.4253990208913;266.2679394134284;3.4894792902116873;7.584732798495995;3.0537650757319774;19.0533724354884;35.313008383849514;58.36062361904447;HELO_2401;uncharacterized protein;;;;;;;;;HELO_2401;uncharacterized protein;1.0676748665699742;0.10074816568821987;-0.07104408644330018;-0.4801883814696817;-1.547863248039656
HELO_2402;230.87990265075328;14.129855998403784;373.36564610596173;692.6653243356304;173.89965872604512;294.03152259843586;8.270996591607062;0.531556552424283;57.17778174567501;7.098862190109635;81.84113138168229;144.9491732846205;HELO_2402;glycosyltransferase domain protein;COG4783;Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains;BepA;HELO_RS07705;MO;;;;HELO_2402;glycosyltransferase domain protein;3.9379076234658523;0.3435789439531547;-0.7543416330480106;-0.3474913221993239;-4.285398945665176
HELO_2403;17.914234355384846;2.332540573831744;24246.726849980187;41864.925945749776;9891.934850032616;17667.018589914558;1.449145430963493;0.18331971738952899;3203.3305882764002;1851.5015435153812;8560.291984455283;15295.640985698852;HELO_2403;uncharacterized protein;;;;;;;;;HELO_2403;uncharacterized protein;2.5047780321369766;0.4567092499392231;-0.8366697742129077;-9.867452162578761;-12.372230194715737
HELO_2404;114.46211256372248;83.2760499497004;83.24572041396108;134.42787458209276;113.13957345176651;81.55120239110109;13.166526447884985;8.910052841601837;6.144464174518387;7.535554654786742;3.726549832281435;9.404994129473362;mntP;probable manganese efflux pump MntP;COG1971;Putative Mn2+ efflux pump MntP;MntP;HELO_RS07720;P;mntP; probable manganese efflux pump MntP;;mntP;probable manganese efflux pump MntP;0.4542249259184423;0.029314172182619558;0.46743794284503437;0.48405839327795874;0.02983346735951642
HELO_2405;27.954110049982116;23.973621856944646;19.084007227435894;21.088682987433966;22.03995483031565;17.70747686247435;1.751973405101788;1.7024832341987428;0.6607413929728447;0.5686419924715711;1.488665423368032;1.0683252449262994;HELO_2405;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS07725;K;;mntP;;HELO_2405;LysR family transcription regulator;0.21336308740676468;0.10243215850434506;0.3005228976058172;0.6301531632298802;0.41679007582311556
HELO_2406;5.945465601887489;9.782424909308068;11.21129439868063;8.667348358239177;13.04662468378393;11.573411895944675;0.251725873484471;0.8672831045748213;0.49436549427798276;0.8725385193839069;0.7548576400125253;1.055379309384621;HELO_2406;alpha/beta hydrolase fold protein;COG2936;Predicted acyl esterase;;HELO_RS07730;R;;;;HELO_2406;alpha/beta hydrolase fold protein;-0.6345383526863122;-0.04216005545051349;0.15984731174958045;-0.8562328734893785;-0.2216945208030663
HELO_2407;206.50687576921135;140.3168426334104;191.88414716963607;187.5771878907773;164.843387559754;187.94430273105363;9.71004650573826;6.8044378259152865;1.364667433354188;9.744587839995804;10.732044323299464;8.907372680307882;wcbT;probable aminotransferase WcbT;COG0156;7-keto-8-aminopelargonate synthetase or related enzyme;BioF;HELO_RS07740;H;wcbT; probable aminotransferase WcbT;2.3.1.47;wcbT;probable aminotransferase WcbT;0.5542257198145224;0.029773558099692288;-0.18813952670903333;0.13519812372206008;-0.4190275960924623
HELO_2408;72.6638705533076;63.47230069469568;62.75292586409802;68.62227997206104;45.79085204548782;58.58907614714652;4.384974784020745;4.7412040664717585;0.841559003553696;5.408005418202657;3.6443527270027536;7.758024275411271;wcbQ;capsular polysaccharide biosynthesis protein WcbQ;COG1368;Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily;MdoB;HELO_RS07750;M;wcbQ; capsular polysaccharide biosynthesis protein WcbQ;;wcbQ;capsular polysaccharide biosynthesis protein WcbQ;0.1922777363999577;0.0974436737772777;-0.3488213805498148;0.3059093229195611;0.11363158651960337
HELO_2409;158.91900096795678;119.45371380283876;104.9554705233795;107.07444713648096;89.57878335200455;104.76353978590787;10.506589188540875;4.596802599287361;0.5931390785990454;5.480626108980063;11.550318059203697;15.32353505497594;wcbP;probable oxidoreductase WcbP (short-chain dehydrogenase family);COG0300;Short-chain dehydrogenase;YqjQ;HELO_RS07755;R;wcbP; probable oxidoreductase WcbP (short-chain dehydrogenase family);;wcbP;probable oxidoreductase WcbP (short-chain dehydrogenase family);0.4088624894212023;0.0026157084202500513;-0.22359730168544534;0.5964989964090552;0.18763650698785295
HELO_2410;82.31237440373856;66.77569431496602;76.90984764637663;75.49021386369198;57.90492970913883;75.09765540101539;3.691940066131458;1.8570535380584297;2.9689824206625977;3.430117928750038;8.128264900377532;15.51172582163322;wcbO;capsular polysaccharide export protein WcbO;COG3562;Capsule polysaccharide modification protein KpsS;KpsS;HELO_RS07760;M;wcbO; capsular polysaccharide export protein WcbO;;wcbO;capsular polysaccharide export protein WcbO;0.29776280774254804;0.03395368912671426;-0.3694636272383125;0.130678790884601;-0.16708401685794705
HELO_2411;105.22795755270964;62.028007658179895;84.00850187876071;88.60119007036445;66.68328603521111;78.2652424851887;5.182071209914516;5.047031982010048;4.548455571284308;8.536818333935535;9.767313960022063;15.585253167414178;wcbA;capsule polysaccharide modification protein WcbA;COG3563;Capsule polysaccharide export protein KpsC/LpsZ;KpsC;HELO_RS07765;M;wcbA; capsule polysaccharide modification protein WcbA;;wcbA;capsule polysaccharide modification protein WcbA;0.7530985467310662;0.10091874726157535;-0.227888774913362;0.4224032178225192;-0.330695328908547
HELO_2412;11.456430897885724;2.037745367108833;17.030192204124905;7.416913369185731;9.229367851761284;27.330255014744946;1.4966975747469031;0.8687383534645086;13.756812878419211;0.3713977660999152;1.588600365564802;33.11156683340282;HELO_2412;YdiE family protein;COG4256;Hemin uptake protein HemP;HemP;HELO_RS07770;H;;wcbA;;HELO_2412;YdiE family protein;2.0358179076692666;-0.6519288120280713;-1.4696265951423308;-1.185452831509548;-3.2212707391788147
HELO_2413;10.533299493426634;4.655588665079908;6.511177230323824;3.6020415562780634;5.137089926132325;10.543864118642798;1.696690361726388;0.2705331872505704;5.238034577477677;0.6252635255351376;0.8673052021282817;11.957133905050776;hmuR;TonB-dependent receptor HmuR (probable substrate hemin);COG4771;Outer membrane receptor for ferrienterochelin and colicins;FepA;HELO_RS07775;P;hmuR; TonB-dependent receptor HmuR (probable substrate hemin);;hmuR;TonB-dependent receptor HmuR (probable substrate hemin);1.0280562032730223;-0.6200152784190274;-0.911499594860318;-0.0013209191327998582;-1.0293771224058221
HELO_2414;9.238875762476829;6.059947384816335;9.953885686164448;6.797577337771588;10.887478201059343;16.761351137716648;0.29566816036704946;0.857459910971385;6.325941506184623;1.3377300033910249;1.3634929408937826;14.464625539740178;hmuS;heme-binding protein HmuS;COG3720;Putative heme degradation protein;HemS;HELO_RS07780;P;hmuS; heme-binding protein HmuS;;hmuS;heme-binding protein HmuS;0.5363279780802128;-0.697298604539371;-0.5792986387395911;-0.7946840193967493;-1.331011997476962
HELO_2415;8.865231000916179;4.57246451482337;6.412838674068929;7.511522792676332;8.013402847246518;9.66159079037545;0.5613887502032547;0.3343760753927726;2.997311908375725;0.2802048254733162;0.8378757360518712;8.041429086832183;hmuT;ABC-type transport system periplasmic substrate-binding protein (probable substrate hemin);COG4558;ABC-type hemin transport system, periplasmic component;ChuT;HELO_RS07785;P;hmuT; ABC-type transport system periplasmic substrate-binding protein (probable substrate hemin);;hmuT;ABC-type transport system periplasmic substrate-binding protein (probable substrate hemin);0.8240373084999408;-0.524324695815658;-0.2422789378085315;-0.11199797710610238;-0.9360352856060432
HELO_2416;9.74044767922625;5.4096984273509285;7.26358735144112;7.333979644832848;8.192029175525382;11.582579909117209;0.5501823453753748;0.4157242085769209;2.282527636065123;0.28481926118999434;0.5391640095902036;9.652630337646977;hmuU;ABC-type transport system permease protein (probable substrate hemin);COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS07790;P;hmuU; ABC-type transport system permease protein (probable substrate hemin);;hmuU;ABC-type transport system permease protein (probable substrate hemin);0.744725742862729;-0.6065876410603268;-0.452972477871711;-0.22837363165489322;-0.9730993745176222
HELO_2417;12.000682977539853;5.757623901413672;5.681250220822569;4.704514197359441;6.158229915903685;6.335965838639967;0.9534954255335097;0.12259498858494874;2.726234407972433;0.920316220490956;0.4026827338736049;5.78110140386165;hmuV;ABC-type transport system ATP-binding protein (probable substrate hemin);COG1120;ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component;FepC;HELO_RS07795;HP;hmuV; ABC-type transport system ATP-binding protein (probable substrate hemin);7.2.2.-;hmuV;ABC-type transport system ATP-binding protein (probable substrate hemin);0.9439994517384793;-0.1348688302411576;-0.03538403819191327;0.8255285898786098;-0.11847086185986955
HELO_2418;198.27018693528134;91.41270414950009;212.35880369864864;265.15172697986714;143.72641555427035;184.72235626699708;4.264029045121;1.31570499606601;7.099928809089595;18.596101863593116;11.954698720249688;20.529436117546595;HELO_2418;uncharacterized protein;COG3774;Mannosyltransferase OCH1 or related enzyme;OCH1;HELO_RS07800;M;;hmuV;;HELO_2418;uncharacterized protein;1.1085627824839328;0.20013415117966016;-0.359819222174818;0.10157839322849416;-1.0069843892554386
HELO_2419;57.595688650778634;15.40961399552558;42.99164884529736;47.08528973159679;55.27959354205229;37.75093607203582;2.884143512691448;2.3238398991827895;5.594159420523328;4.388463232803228;2.7491453065929976;4.06529684960611;HELO_2419;uncharacterized protein;;;;;;;;;HELO_2419;uncharacterized protein;1.8362532154076199;0.18299851501363307;0.5383807485822247;0.5965633573301679;-1.239689858077452
HELO_2420;272.3014541920068;193.8641884571738;300.5535016701863;303.26560633298544;271.33727145826913;294.6513862856493;10.255202303389282;8.403152858660503;8.883504332697122;9.153787012142987;17.62649818558473;18.64455698334078;prfC;peptide chain release factor 3;COG4108;Peptide chain release factor RF-3;PrfC;HELO_RS07810;J;prfC; peptide chain release factor 3;;prfC;peptide chain release factor 3;0.4880241553378424;0.028516946218166694;-0.11850260195085127;-0.1134039055756606;-0.601428060913503
HELO_2421;17.8774812816515;18.848001711478506;46.40833027048044;78.04643607418967;70.74350054313179;48.995035219937485;0.7669991004624015;0.2449644937372692;1.023949557085811;5.983314550299016;6.643064906138181;6.494338105847281;HELO_2421;acyl-CoA synthetase family protein;COG0318;O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming);MenE/FadK;HELO_RS07815;I;;prfC;6.2.1.-;HELO_2421;acyl-CoA synthetase family protein;-0.07232747805821216;-0.07664425251075269;0.521063305174871;-1.4051185478158743;-1.3327910697576622
HELO_2422;27.407268765267602;34.988371991328734;56.52389349241641;96.99813288385049;57.79638325212135;55.80037100372508;1.5056542620722109;1.8621401475609503;5.362040080830911;18.62451064333561;2.8454404356997784;5.43040270484521;HELO_2422;MerR family transcription regulator;COG0789;DNA-binding transcriptional regulator, MerR family;SoxR;HELO_RS07820;K;;;;HELO_2422;MerR family transcription regulator;-0.3412707110629132;0.018260974556238985;0.04982706011404936;-0.99964022365823;-0.6583695125953168
HELO_2423;21.214345554883806;16.41907095635195;38.355573221339405;52.34708593087487;81.32955285185984;39.7900238951998;0.7722439888810348;0.7426145555710877;1.66106769215347;4.968073236748585;4.247910847717636;4.038433118243954;HELO_2423;isobutyryl-CoA dehydrogenase;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS07825;I;;;;HELO_2423;isobutyryl-CoA dehydrogenase;0.350823959440584;-0.05164839914909525;1.0131940382701385;-0.8767247127793141;-1.227548672219898
HELO_2424;35.503535156822174;21.510387711938602;45.8734504859064;61.475262175921124;127.90640797261521;46.70336510517146;1.9761608266955832;2.038030457767649;2.6543392213824326;3.5164731947585164;9.738022415884775;3.4273134236542253;HELO_2424;crotonase domain protein (homolog to 3-hydroxyisobutyryl-CoA hydrolase);COG1024;Enoyl-CoA hydratase/carnithine racemase;CaiD;HELO_RS07830;I;;;;HELO_2424;crotonase domain protein (homolog to 3-hydroxyisobutyryl-CoA hydrolase);0.697445281913363;-0.025320041302719254;1.4341610362832338;-0.38605485339781254;-1.0835001353111755
HELO_2425;32.28174767689666;18.680767050895437;37.587594832204616;56.11270094227274;136.6613111881379;40.99627686090708;0.3591525548291374;1.465135947876254;2.1059306347030167;6.105884059576582;7.445035926084959;2.7555246938994227;mmsB;3-hydroxyisobutyrate dehydrogenase;COG2084;3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase;MmsB;HELO_RS07835;I;mmsB; 3-hydroxyisobutyrate dehydrogenase;1.1.1.31;mmsB;3-hydroxyisobutyrate dehydrogenase;0.7579447433540105;-0.12212430944727704;1.7127898184782264;-0.3355302391813826;-1.093474982535393
HELO_2426;27.109516131083325;37.13408505610858;51.65228494825707;57.619120084706594;94.39468404131681;56.68484984679085;0.17554816266122691;1.5258230763351508;1.1490926257222362;2.3488775458673428;5.56139775451866;5.328509435946973;gcdH;glutaryl-CoA dehydrogenase;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS07840;I;gcdH; glutaryl-CoA dehydrogenase;1.3.8.6;gcdH;glutaryl-CoA dehydrogenase;-0.4400224660584868;-0.13169632292409883;0.7257164088403645;-1.0371338442841758;-0.5971113782256889
HELO_2427;20.540355988905805;33.40748385415281;38.748214366392965;37.63847732103745;54.06173493851011;35.38213830344309;0.906122930333418;4.382825945006988;0.9235126890827933;3.4265916959437543;0.7646095240939449;2.59369015651372;HELO_2427;succinate--hydroxymethylglutarate CoA-transferase;COG1804;Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases;CaiB;HELO_RS07845;I;;gcdH;;HELO_2427;succinate--hydroxymethylglutarate CoA-transferase;-0.6756803017965911;0.1276597131390078;0.5978197308507633;-0.7561882447055686;-0.08050794290897745
HELO_2428;46.507554200557024;9.893617388368606;29.04060645263083;22.18361916984595;30.60177609263407;35.015395046528404;1.4322028265601114;0.43048880586137883;12.487630115095333;3.087422111975207;3.963614184283071;24.97492403539956;HELO_2428;DUF1513 family protein;COG3490;Uncharacterized conserved protein, DUF1513 domain;;HELO_RS07850;S;;;;HELO_2428;DUF1513 family protein;2.1246738333118436;-0.2616997911130863;-0.18860808557764042;0.399543206318417;-1.7251306269934266
HELO_2429;40.34986871422339;7.837459045186269;28.057802871225118;16.960230040504168;25.60689737221885;30.2692877009795;2.3717345836396126;0.6137157763300423;12.644160635869982;0.1913208279324427;3.642306276333877;20.15389486763937;HELO_2429;uncharacterized protein;COG3489;Imelysin-like iron-regulated protein IrpA, duplicated M75 peptidase-like domain;IrpA2;HELO_RS07855;R;;;;HELO_2429;uncharacterized protein;2.2261792195788446;-0.1058207342210098;-0.23294606811643526;0.4031363930964442;-1.8230428264824003
HELO_2430;69.86397959266377;17.505227930833282;63.48907044383569;34.88182675833051;51.26788594698352;69.58957435333353;10.872350305787824;0.7990087481092537;28.44294529937049;4.624398886550492;4.340789812120903;46.469501375711175;HELO_2430;DUF1111 domain protein;COG3488;Uncharacterized conserved protein with two CxxC motifs, DUF1111 family;;HELO_RS07860;R;;;;HELO_2430;DUF1111 domain protein;1.9371195812963853;-0.13040044758212055;-0.43353031351777727;0.005597364838545005;-1.9315222164578403
HELO_2431;123.45097793247244;47.64274941336172;163.2157003407324;80.69710304336353;154.69356092570783;193.39762857226592;8.420882664281892;3.0092350795684113;91.63312949441746;9.248360510154498;9.758228194485923;160.69090183936342;HELO_2431;uncharacterized protein;COG3487;Imelysin-like iron-regulated protein IrpA, duplicated M75 peptidase-like domain;IrpA;HELO_RS07865;S;;;;HELO_2431;uncharacterized protein;1.3552808859879653;-0.24341855287842584;-0.32030134023312495;-0.6434330528062597;-1.998713938794225
HELO_2432;69.55893648945137;29.893018125699086;83.80076623361508;85.75071631326132;89.58212083731804;84.67229743657809;4.3948476716991465;3.4957901367764976;7.748288639587881;4.1464325195907215;12.500676004233544;8.740964667162649;ppsR;regulatory protein kinase PpsR;COG1806;Regulator of PEP synthase PpsR, kinase-PPPase family (combines ADP:protein kinase and phosphorylase activities);PpsR;HELO_RS07870;T;ppsR; regulatory protein kinase PpsR;2.7.4.28,2.7.11.33;ppsR;regulatory protein kinase PpsR;1.1915479923628158;-0.01475147653296105;0.08039754108109776;-0.2799999613147035;-1.4715479536775193
HELO_2433;185.020342318616;145.2965732146208;152.7692064789294;160.061354503755;1000.9355951757567;148.63306788606948;11.955083922250944;2.5516907526329793;8.218222849790855;0.4717696977889933;27.993389231458167;14.741600527298319;ppsA;phosphoenolpyruvate synthase;COG0574;Phosphoenolpyruvate synthase/pyruvate phosphate dikinase;PpsA;HELO_RS07875;G;ppsA; phosphoenolpyruvate synthase;2.7.9.2;ppsA;phosphoenolpyruvate synthase;0.34656441954345585;0.03933758472120097;2.743288833170814;0.3140313601625131;-0.03253305938094275
HELO_2434;78.1624123312961;81.83597319436039;68.55132432604135;66.44127816323301;127.94546999381883;55.744484633045175;3.5445236339854906;2.752387841102618;5.332521483287896;7.581354193973511;11.278989565934616;3.2241952105293783;HELO_2434;uncharacterized protein;;;;;;;;;HELO_2434;uncharacterized protein;-0.06544184668577113;0.29359781110307903;1.1842090110621397;0.4803354023093558;0.5457772489951269
HELO_2435;33.56627270705147;21.661602653596564;26.737190564476588;21.23350194904389;46.358368461843234;28.58376904675664;1.9462517529011754;1.1722116705235615;0.3701618768419769;0.43009000796086394;1.6139897726721468;2.8457597885196475;HELO_2435;GlpQ domain protein;COG0584;Glycerophosphoryl diester phosphodiesterase;UgpQ;HELO_RS07885;I;;;3.1.4.46;HELO_2435;GlpQ domain protein;0.609115151935022;-0.09298419929560264;0.6788135125566273;0.22455917855822793;-0.38455597337679404
HELO_2436;103.21718726606424;75.49769425247585;272.1466442974167;201.21171384504814;427.33469687603383;290.30928090094693;8.951395459686776;8.294852650676106;11.331170690544038;12.549957001210407;14.481528109149952;16.944172077695434;HELO_2436;4-hydroxy-4-methyl-2-oxoglutarate aldolase;COG0684;RNA degradosome component RraA (regulator of RNase E activity);RraA;HELO_RS07890;J;;;;HELO_2436;4-hydroxy-4-methyl-2-oxoglutarate aldolase;0.44610505455944693;-0.09287596629201289;0.5561868807866652;-1.482958442134998;-1.9290634966944449
HELO_2437;625.8857232930544;1174.957805570577;1261.659036725937;1036.959325859611;2962.1993322103067;1311.612354336482;47.02424184874686;30.15569194935529;120.20905228951662;109.63506939684167;67.45249708552141;86.42357466716756;acnB;aconitate hydratase / 2-methylisocitrate dehydratase;COG1049;Aconitase B;AcnB;HELO_RS07895;C;acnB; aconitate hydratase / 2-methylisocitrate dehydratase;4.2.1.3,4.2.1.99;acnB;aconitate hydratase / 2-methylisocitrate dehydratase;-0.9075619166032141;-0.05597580469815533;1.1747147616283389;-1.0661665376581162;-0.15860462105490214
HELO_2438;82.80978656418307;47.28213448623942;154.15498700193464;150.06612701690537;145.7416891477363;164.7459718849013;4.0941345291117015;6.515524263893771;2.948534675600183;8.501640371019331;15.151416324919806;17.083329709841166;HELO_2438;DUF1289 domain protein;COG3313;Predicted Fe-S protein YdhL, DUF1289 family;YdhL;HELO_RS07900;R;;acnB;;HELO_2438;DUF1289 domain protein;0.7956292618528149;-0.09526374021484241;-0.17569501175543945;-0.9837831850106964;-1.7794124468635113
HELO_2439;102.55367226995553;78.01691111855949;114.27978163167721;106.51452676685659;105.13255825353882;108.54925214407403;3.954569762879393;7.855488583288828;9.000912388886414;2.2550849983978196;0.7907904610981193;6.22899579584187;miaE;tRNA-(ms(2)io(6)A)-hydroxylase;COG4445;tRNA isopentenyl-2-thiomethyl-A-37 hydroxylase MiaE (synthesis of 2-methylthio-cis-ribozeatin);MiaE;HELO_RS07905;J;miaE; tRNA-(ms(2)io(6)A)-hydroxylase;1.14.99.69;miaE;tRNA-(ms(2)io(6)A)-hydroxylase;0.3901453604426264;0.07355987224027238;-0.04571233628524585;-0.08120091955900843;-0.4713462800016348
HELO_2440;332.18279128243256;145.95506053309737;257.7802727701593;261.4328691205115;306.1480159584565;266.5657322725846;14.391584459564132;4.213858518245508;21.862272940399446;9.960511880747477;15.788697268595106;10.553858026943937;HELO_2440;uncharacterized protein;COG3899;Predicted ATPase;;HELO_RS07910;R;;miaE;;HELO_2440;uncharacterized protein;1.1809388478010563;-0.04816571611163667;0.1990407054473451;0.3164205294735183;-0.864518318327538
HELO_2441;43.26591944467935;68.97153573545661;12.079327885530006;12.958906832892795;9.676617902636055;12.99333041231545;3.181636052360715;2.4789102587261955;3.228641696325411;2.4720516645967296;4.049081163876302;2.950792204638136;HELO_2441;UPF0153 family protein;;;;;;;;;HELO_2441;UPF0153 family protein;-0.6605717683429386;-0.097450958562316;-0.39028465666662226;1.6614570231762849;2.3220287915192235
HELO_2442;79.19336383218966;148.6760154741103;85.66050177282511;73.27318000534812;59.41647390158109;86.59481900974185;6.899036431381137;9.305313730714886;11.787104387950604;7.53878583084428;1.3518803780104638;8.055701059344747;queD;6-carboxy-5%2C6%2C7%2C8-tetrahydropterin synthase;COG0720;6-pyruvoyl-tetrahydropterin synthase;QueD;HELO_RS07920;H;queD; 6-carboxy-5,6,7,8-tetrahydropterin synthase;;queD;6-carboxy-5%2C6%2C7%2C8-tetrahydropterin synthase;-0.9002882974971484;-0.015470950965099206;-0.5359035547136433;-0.12736268534369888;0.7729256121534496
HELO_2443;80.59296266265495;172.3807396455235;63.29662545037372;48.92363638005366;37.047961456216825;63.43741126815964;8.415850839583218;7.97620784076991;9.45478812146834;5.080405990007043;4.155772748264631;6.749325211477106;queE;7-carboxy-7-deazaguanine synthase;COG0602;Organic radical activating enzyme NrdG/QueE;QueE;HELO_RS07925;H;queE; 7-carboxy-7-deazaguanine synthase;4.3.99.3;queE;7-carboxy-7-deazaguanine synthase;-1.087427011515607;-0.0031555148474833317;-0.7600793771554617;0.34054619024294563;1.4279732017585527
HELO_2444;68.44311480435591;126.91369296928026;62.40159554084758;56.378474317665756;41.6386304214534;66.064352728076;3.7349337318771654;9.557847024071185;7.198840222299418;4.388965453740735;5.754238114376936;8.973024194547351;queC;7-cyano-7-deazaguanine synthase;COG0603;7-cyano-7-deazaguanine synthase (queuosine biosynthesis);QueC;HELO_RS07930;J;queC; 7-cyano-7-deazaguanine synthase;6.3.4.20;queC;7-cyano-7-deazaguanine synthase;-0.8812671457803809;-0.08102697534525305;-0.6533850238849954;0.050285537446238315;0.9315526832266192
HELO_2445;239.03860770160534;272.75346157067696;237.58306195694766;360.9681318899611;243.49438346125987;241.6951393212956;9.678399085975132;9.06362337070431;16.478354398869463;6.002859232155697;14.919897213213446;21.295369376314763;HELO_2445;peptidase U32 family protein;COG0826;23S rRNA C2501 and tRNA U34 5'-hydroxylation protein RlhA/YrrN/YrrO, U32 peptidase family;RlhA;HELO_RS07935;J;;queC;3.4.-.-;HELO_2445;peptidase U32 family protein;-0.18961074056990146;-0.024653591087862914;0.010656109288177618;-0.015878747680782013;0.17373199288911945
HELO_2446;143.32130753769295;121.72653789415499;182.23193070030865;287.75748786619147;181.4538848085202;154.51347829774662;3.197314370890397;7.539706973537437;8.373762989102502;14.288811134055235;13.206685796089516;7.727832640290907;HELO_2446;START domain protein;COG5637;Uncharacterized protein, contains SRPBCC domain;;HELO_RS07940;S;;;;HELO_2446;START domain protein;0.23383706912696667;0.2366313112847802;0.23049224547566105;-0.10775530919104526;-0.3415923783180119
HELO_2447;34.027975106074216;28.662972505236052;24.903731310613626;33.86582278913922;40.74195014276713;22.26922047580133;2.7811022682662903;2.4605326846538116;4.05669537542936;1.4390113600245544;8.009360797391016;3.0866074934934935;HELO_2447;DUF2789 domain protein;;;;;;;;;HELO_2447;DUF2789 domain protein;0.23984441489595465;0.1547370453735164;0.843075122423028;0.590084710430232;0.3502402955342774
HELO_2448;96.7867569294312;103.61032196833763;98.68398181397676;107.68994183757808;92.87152939649697;103.64207902808738;2.091133947207496;4.06376666220563;2.463105426066868;3.8803978425910124;6.662764950266564;10.436718012607995;ansA;L-asparaginase 1;COG0252;L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D;AnsA;HELO_RS07950;JE;ansA; L-asparaginase 1;3.5.1.1;ansA;L-asparaginase 1;-0.0973142081323175;-0.07002950751642967;-0.1567035400581318;-0.09775210755662833;-0.00043789942431082807
HELO_2449;183.37338981939024;162.11178487193897;179.81863926749182;191.03391197373676;145.28478346086203;189.1241973602871;4.986034780803758;7.522120315736372;5.85443829901179;8.880825358055517;2.473557717382247;14.077216338216136;HELO_2449;major facilitator superfamily transport protein;COG2807;Cyanate permease;CynX;HELO_RS07955;P;;ansA;;HELO_2449;major facilitator superfamily transport protein;0.17676942905259452;-0.07239875512424909;-0.3781624492121116;-0.04431170740766266;-0.22108113646025718
HELO_2450;268.2072528861897;208.59160458814063;267.1139831694242;261.4890453807513;237.25803935456125;284.50062856654154;4.730788024016369;14.48103494603139;6.995001001974436;27.472394776551532;34.649123155536145;23.662769662945482;HELO_2450;uncharacterized protein;;;;;;;;;HELO_2450;uncharacterized protein;0.3611363496816269;-0.09064745852573353;-0.2609690271850216;-0.08477664282204778;-0.44591299250367467
HELO_2451;487.71256339121663;428.4289669875927;501.83276165542344;530.9823707144955;378.1512693092798;496.8613841669051;26.855059483259808;7.69056026383054;19.503220825420836;18.52793304856743;44.693423739437264;12.06478030032497;rhlE;ATP-dependent RNA helicase RhlE;COG0513;Superfamily II DNA and RNA helicase;SrmB;HELO_RS07965;L;rhlE; ATP-dependent RNA helicase RhlE;3.6.4.13;rhlE;ATP-dependent RNA helicase RhlE;0.1865666816006506;0.014334531052867305;-0.3929705666489145;-0.026757926785810682;-0.21332460838646128
HELO_2452;136.7304954246391;61.684142208812034;92.28219528856471;156.58943385022792;126.88009158327073;105.99245141656938;3.4366330108088525;1.2967616699798954;7.119230429796057;8.39249829539464;4.837653856839856;9.533144707144352;HELO_2452;DUF330 family protein;COG3009;Intermembrane transporter PqiABC lipoprotein subunit PqiC;PqiC;HELO_RS07970;M;;rhlE;;HELO_2452;DUF330 family protein;1.1356756050537085;-0.19783536828563886;0.25728266794421906;0.3643390128565622;-0.7713365921971462
HELO_2453;65.98874495158339;37.931050763532944;53.90873488197556;56.16462967193477;54.871644382705405;52.911138385126925;2.251926589813692;0.7846169861304517;2.400087268157999;1.1049132736577192;2.4373474829192854;2.3965290703930866;pqiB;PqiB family protein;COG3008;Intermembrane transporter PqiABC subunit PqiB;PqiB;HELO_RS07975;M;pqiB; PqiB family protein;;pqiB;PqiB family protein;0.7829974388494323;0.026452297652566514;0.051532907730022615;0.31333534916260497;-0.4696620896868273
HELO_2454;124.23600598957823;65.90740742975993;103.47281783343112;114.87143282955132;111.92250037782655;94.01311197241864;6.003300109948992;1.8670468323441185;4.907309967974191;7.4808106832359345;16.741942004913778;10.14254864497268;HELO_2454;PqiA family protein;COG2995;Intermembrane transporter PqiABC subunit PqiA;PqiA;HELO_RS07980;M;;pqiB;;HELO_2454;PqiA family protein;0.9044115561039661;0.1369290981270348;0.2491344523331751;0.39845087739487006;-0.505960678709096
HELO_2455;132.7521775071775;29.19693189970052;80.48695643015049;102.42414859395463;102.52282761944387;77.19731113793388;4.946547407091178;0.3145841217939586;4.45388474860032;5.577411297080416;8.564286409177432;5.338096305925177;HELO_2455;NCKX family transport protein;COG0530;Ca2+/Na+ antiporter;ECM27;HELO_RS07985;P;;;;HELO_2455;NCKX family transport protein;2.147088499117964;0.059450146026141404;0.4047580231583989;0.7743714734622031;-1.3727170256557608
HELO_2456;137.49669693086773;25.63482190746012;72.06938506968145;147.17069256476788;240.1815203311412;65.88005735672651;6.113588981989607;0.5356590057598096;2.5446676738473086;13.375568675866722;18.600255642931568;7.468904378272624;cydA;cytochrome bd ubiquinol oxidase subunit 1;COG1271;Cytochrome bd-type quinol oxidase, subunit 1;AppC;HELO_RS07990;C;cydA; cytochrome bd ubiquinol oxidase subunit 1;7.1.1.7;cydA;cytochrome bd ubiquinol oxidase subunit 1;2.3784660296826745;0.12769098141663182;1.8504713803446178;1.05020357941543;-1.3282624502672444
HELO_2457;94.32335680248657;16.40715686132872;37.50741014455796;79.53482740333118;138.65184194345272;36.48284544832092;4.06086710593017;0.8244562182568412;2.980417093698642;8.792119593922234;2.9347084583803933;3.0776836352842127;cydB;cytochrome bd ubiquinol oxidase subunit 2;COG1294;Cytochrome bd-type quinol oxidase, subunit 2;AppB;HELO_RS07995;C;cydB; cytochrome bd ubiquinol oxidase subunit 2;7.1.1.7;cydB;cytochrome bd ubiquinol oxidase subunit 2;2.4531491722342125;0.03890561949390836;1.8975322201474194;1.3465992798182898;-1.1065498924159227
HELO_2458;86.58381254663836;19.12138115110115;36.18432910384827;75.18226842266026;95.83872267335055;33.05612170866999;1.8672732355712567;1.6993775197708787;2.4350438515302284;3.1418102168567614;0.8148889223234996;1.1089250143534473;cydD;ABC-type transport system ATP-binding/permease protein CydD;COG4988;ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components;CydD;HELO_RS08000;OC;cydD; ABC-type transport system ATP-binding/permease protein CydD;;cydD;ABC-type transport system ATP-binding/permease protein CydD;2.1219349155280893;0.1267805915385436;1.507669898860236;1.362750100957542;-0.7591848145705473
HELO_2459;67.0010854601658;13.374683763633085;33.68655824281844;74.87128850893642;70.45384307015708;30.953678830788295;1.5992641776353824;0.9752699262522743;3.5521769804331425;0.9476667191034309;4.94416995905429;2.7656028173017537;cydC;ABC-type transport system ATP-binding/permease protein CydC;COG4987;ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components;CydC;HELO_RS08005;OC;cydC; ABC-type transport system ATP-binding/permease protein CydC;;cydC;ABC-type transport system ATP-binding/permease protein CydC;2.242027557629203;0.11839465861565213;1.1610295688669439;1.0895757370308994;-1.1524518205983036
HELO_2460;84.49194763998953;60.102333214743574;94.81377971656502;117.31865521066395;123.59816210070956;93.04294440471712;2.434885517837632;1.3557743706458514;11.805223505614137;4.068658219944015;13.772659602371844;4.573449217052127;HELO_2460;adenine deaminase;COG1816;Adenosine/6-amino-6-deoxyfutalosine deaminase;Add;HELO_RS08010;F;;cydC;3.5.4.4;HELO_2460;adenine deaminase;0.4845610701580405;0.02691344669801321;0.4058911735152755;-0.13753116816748356;-0.6220922383255241
HELO_2461;21.233542519768733;17.49958066221194;17.13738622677891;21.051968377833592;20.223181422043666;18.486137265161656;0.5634305632960876;1.7679546277501865;0.16977058829362968;1.105027155989142;1.2680799368023352;0.3830500329607828;fhs;formate--tetrahydrofolate ligase;COG2759;Formyltetrahydrofolate synthetase;MIS1;HELO_RS08015;F;fhs; formate--tetrahydrofolate ligase;6.3.4.3;fhs;formate--tetrahydrofolate ligase;0.26524526555242733;-0.10348156915738649;0.12319280335604788;0.19028970082957564;-0.0749555647228517
HELO_2462;39.09305689246795;26.00454289837785;40.127856268191074;37.3458146953353;35.931620698357115;42.49622243808208;2.930569361624907;0.8977458236984623;4.053615594718965;1.575645212134155;2.233799428053258;3.0268335841199945;HELO_2462;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS08020;GER;;fhs;;HELO_2462;DMT superfamily transport protein;0.5701502916441239;-0.08077423581389276;-0.23603353634211022;-0.11753769128674296;-0.6876879829308669
HELO_2463;17.4361965550851;24.721292216078492;83.9041827390177;45.81543789130271;52.81285426472158;80.35118670218661;1.6436225897677994;1.6932171672992107;3.296469646221325;0.519879998250999;2.1440212113327295;9.987289798355015;guaD;guanine deaminase;COG0402;Cytosine/adenosine deaminase or related metal-dependent hydrolase;SsnA;HELO_RS08025;FR;guaD; guanine deaminase;3.5.4.3;guaD;guanine deaminase;-0.48042207029887596;0.06167223756758933;-0.5962125610225639;-2.1416223372462673;-1.6612002669473913
HELO_2464;16.518503220545046;18.339818875760823;34.21491999526349;22.265780841541712;24.793047548349037;36.803593241472846;1.149019142539212;1.3377843833959087;1.8603280563711808;1.6562096794147048;0.30343290922640803;3.043342197802764;HELO_2464;XdhC family protein;COG1975;Molybdoenzyme maturation factor PaoD (Mo cofactor insertion), XdhC/CoxF family;XdhC;HELO_RS08030;O;;guaD;;HELO_2464;XdhC family protein;-0.14269476706849638;-0.10233656443284822;-0.5515411263082415;-1.1096438530460402;-0.9669490859775438
HELO_2465;20.629718542052316;26.14244763347931;67.7670964677119;43.96268747312079;39.951802706505354;67.58261789559666;1.436922368808796;0.7851624300220119;4.163866338437851;3.078044848871777;3.090383495283964;10.588385418742563;xdhB;xanthine dehydrogenase FAD-binding subunit;COG4631;Xanthine dehydrogenase, molybdopterin-binding subunit XdhB;XdhB;HELO_RS08035;F;xdhB; xanthine dehydrogenase FAD-binding subunit;1.17.1.4;xdhB;xanthine dehydrogenase FAD-binding subunit;-0.32753593274061643;0.0038754573668740022;-0.7439160140493541;-1.6648280827658848;-1.3372921500252684
HELO_2466;20.305049310567593;22.343053643581964;67.73942811945635;39.34122956059116;102.42063140664004;70.17224755616571;1.417187555682655;0.3595408526503055;4.968107461192892;1.9153865008863225;58.581719785626426;8.771973494976102;xdhA;xanthine dehydrogenase molybdenum-binding subunit;COG4630;Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA;XdhA;HELO_RS08040;F;xdhA; xanthine dehydrogenase molybdenum-binding subunit;1.17.1.4;xdhA;xanthine dehydrogenase molybdenum-binding subunit;-0.13179791026352916;-0.0501769465126074;0.5391373171207317;-1.7401194050713222;-1.608321494807793
HELO_2467;85.63810120755046;56.47758978975758;119.99436395668643;123.06875884936703;135.30676395556074;117.5464522908906;6.240185313299724;1.986057395654321;12.687768832051937;5.711519740206473;6.756038946223329;2.9800766114464254;HELO_2467;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS08045;K;;xdhA;;HELO_2467;TetR family transcription regulator;0.5920020581878029;0.02948735852603601;0.20140466652505484;-0.45237895853256127;-1.0443810167203642
HELO_2468;3.017082125013997;4.685019014236542;20.515632744476473;18.502127691545102;10.715933663625824;25.208499025295197;0.3972689211661456;0.017114225231905866;1.3550165416186095;0.5643010731183753;2.3199629787475917;5.349744353707411;HELO_2468;NCS2 family transport protein;COG2252;Xanthine/guanine/uracil/vitamin C permease GhxP/GhxQ, nucleobase:cation symporter 2 ( NCS2) family;NCS2;HELO_RS08050;F;;;;HELO_2468;NCS2 family transport protein;-0.5010172183285668;-0.2846494635777317;-1.161562802398033;-2.705814870939999;-2.204797652611432
HELO_2469;67.59675131958521;44.54558707650106;74.0034211805311;100.81772025395786;108.86149732425311;70.81453625108439;2.3480825661232827;0.7287406332769337;2.103567011289382;3.0532002386929706;5.462676421652527;6.941511188796354;HELO_2469;probable ATP-dependent helicase;COG1643;HrpA-like RNA helicase;HrpA;HELO_RS08055;J;;;3.6.4.13;HELO_2469;probable ATP-dependent helicase;0.5908289755672387;0.06268050875977149;0.6133380598184841;-0.06613564167327102;-0.6569646172405097
HELO_2470;123.11697683538385;85.10170464278494;75.52585035583574;76.09248027229548;92.9265046167294;74.42109588355618;9.191368387196032;3.9380870234254544;8.8698480230468;9.030125628869666;5.286961949960921;5.210018110832834;HELO_2470;UPF0225 family protein;COG3012;Uncharacterized conserved protein YchJ, contains N- and C-terminal SEC-C domains;YchJ;HELO_RS08060;S;;;;HELO_2470;UPF0225 family protein;0.5275867566183825;0.020979057801312706;0.31656420842931343;0.7186604437420057;0.19107368712362316
HELO_2471;363.29645930978626;270.42642636585634;265.26335905402993;293.527427804851;257.8026521525228;269.8821805415382;54.016734200279785;38.62145469307327;20.494907645456113;42.7718934996683;49.961915945605085;36.787010237143996;HELO_2471;uncharacterized protein;;;;;;;;;HELO_2471;uncharacterized protein;0.4245517833075283;-0.024811581237395686;-0.06581308994148571;0.42744748145934786;0.002895698151819559
HELO_2472;125.75173532973974;78.82371127943502;57.58131641111206;83.47635833983374;78.49676106790183;52.93146513533637;4.605075053173006;8.731160457482613;2.711112712026759;3.051695103438751;3.801626789754621;3.0457114426462546;HELO_2472;DUF461 family protein;COG2847;Copper(I)-binding protein;;HELO_RS08070;P;;;;HELO_2472;DUF461 family protein;0.6671162375942776;0.11931338560803173;0.5597688544296417;1.2328063663460007;0.5656901287517231
HELO_2473;112.11557207284908;69.90085202298313;47.863374319960634;61.69454259859527;70.63822294050188;51.47999540661397;2.989876087262115;6.596155984791294;3.6861665163119497;0.9882347070527088;9.154231464048546;0.7375989098585518;HELO_2473;SCO1 family protein;COG1999;Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family;Sco1;HELO_RS08075;O;;;;HELO_2473;SCO1 family protein;0.6739226821378903;-0.10301409956968044;0.44896195655744453;1.107958053042565;0.4340353709046747
HELO_2474;68.78549122352551;81.59585938616961;144.822904277748;164.98238185471396;134.872779513989;162.54357383523913;4.902969385485593;1.0067165263591507;6.632438870101924;10.050299267394186;8.042187707752207;11.578322317402975;HELO_2474;NhaC family sodium/proton antiporter domain protein;COG2056;Predicted histidine transporter YuiF, NhaC family;YuiF;HELO_RS08080;E;;;;HELO_2474;NhaC family sodium/proton antiporter domain protein;-0.24314233609478997;-0.1654577319744588;-0.2674186139429251;-1.2286760435863275;-0.9855337074915376
HELO_2475;61.52148661986055;38.04805064430826;58.16542169080028;61.161948876664404;71.55411600248685;62.31411967217026;4.250182826969874;2.579997187428577;1.428614124325106;3.8565700032540944;5.68412780974103;3.5896252987202097;hutH;histidine ammonia-lyase;COG2986;Histidine ammonia-lyase;HutH;HELO_RS08085;E;hutH; histidine ammonia-lyase;4.3.1.3;hutH;histidine ammonia-lyase;0.6791015547943111;-0.09777300923721466;0.19653019011713635;-0.018175187957227834;-0.697276742751539
HELO_2476;1.921335178363166;4.232349423794918;9.97035712973142;6.93386281701308;24.048803433289308;11.130869651092551;0.21050066068484471;0.4541796486621171;0.47905154763732266;0.8266240945372189;0.33221592294029967;1.1628498147284017;hutU;urocanate hydratase;COG2987;Urocanate hydratase;HutU;HELO_RS08090;E;hutU; urocanate hydratase;4.2.1.49;hutU;urocanate hydratase;-0.8408309945248134;-0.14507248757539726;1.0460587086962243;-2.0539831797868544;-1.2131521852620413
HELO_2477;1.4741873552287654;1.8068574604853882;3.883781982865402;3.36892994076846;8.79200299843562;4.969351545181606;0.16670008156215296;0.7607724600906774;1.1986373581440715;0.7042826885434991;2.2163936392417445;0.9291765607577798;hutG;formimidoylglutamase;COG0010;Arginase/agmatinase family enzyme;SpeB;HELO_RS08095;E;hutG; formimidoylglutamase;3.5.3.8;hutG;formimidoylglutamase;-0.18200105089643714;-0.2895754206865462;0.714029780768056;-1.2706194680224936;-1.0886184171260564
HELO_2478;3.110644273419018;2.782194093415152;6.894884391579502;5.087680955130474;10.322079481987629;6.705906159956586;0.1382102594933062;0.30998141490331155;1.1087303643921265;0.4627922468026865;2.130986563430424;0.3779124729411599;hutI;imidazolonepropionase;COG1228;Imidazolonepropionase or related amidohydrolase;HutI;HELO_RS08100;Q;hutI; imidazolonepropionase;3.5.2.7;hutI;imidazolonepropionase;0.12014112853841996;0.03495352276480013;0.5551024341114887;-0.9066000879447995;-1.0267412164832195
HELO_2479;2.0369548847097243;2.03764451274035;5.9105228504153375;5.1904674868504;12.987412302879614;6.013488332994324;0.3133482186343673;0.040949658105320905;0.21354459206908658;0.298654872121241;0.6350348332563686;1.0265705681385766;HELO_2479;uncharacterized protein;COG3314;Spore dipicolinate transporter SpoVV/YjiH/YlbJ, contains nucleoside recognition GATE domain;SpoVV;HELO_RS08105;DE;;hutI;;HELO_2479;uncharacterized protein;-0.0003275682490382348;-0.021337313928473378;0.9959249977955191;-1.2075067062317923;-1.2071791379827541
HELO_2480;44.859126638631295;17.758465295180553;48.24401495266745;50.134811664543726;60.604907976616396;46.162442919578304;2.115445198319534;0.8045156116087578;6.415473510855203;1.2179282246091645;9.124005225611135;6.140662758603999;hutC;HutC family transcription regulator HutC;COG2188;DNA-binding transcriptional regulator, GntR family;MngR;HELO_RS08110;K;hutC; HutC family transcription regulator HutC;;hutC;HutC family transcription regulator HutC;1.2896670798123964;0.06230994317501892;0.38540684403808445;-0.04042956908956974;-1.330096648901966
HELO_2481;83.22257863371311;33.73189313646494;69.51569406377884;94.57222530753562;82.27346628175542;72.6489023919014;3.763439873203695;1.2623789451757335;7.145874908001993;4.716038352293889;3.3866417122099337;5.318441013122166;HELO_2481;DUF938 family protein;;;;;;;;;HELO_2481;DUF938 family protein;1.2779459969671079;-0.0627196432588022;0.17719285322824607;0.19354302244887478;-1.084402974518233
HELO_2482;102.46851057909326;48.85956897555766;50.39078853680519;56.57229389250696;51.208248028897;41.89418991659579;4.074330688025837;2.7766347080305342;3.7614590628060594;3.2371697872733316;4.556574402351099;1.2330665433503223;HELO_2482;LsrR family transcription regulator;COG2390;DNA-binding transcriptional regulator LsrR, DeoR family;DeoR;HELO_RS08120;K;;;;HELO_2482;LsrR family transcription regulator;1.0532494510716957;0.2607275432126359;0.28349550074170526;1.2703376164740483;0.21708816540235265
HELO_2483;4.900692380311303;16.86752724566337;109.35694409318984;39.489299484210484;62.75446286209321;113.32248895560201;0.28931243122224476;0.950382773258938;15.811982771964132;1.2182841585475452;5.908306992638513;17.640863268759425;HELO_2483;ABC-type transport system periplasmic substrate-binding protein;COG1653;ABC-type glycerol-3-phosphate transport system, periplasmic component;UgpB;HELO_RS08140;G;;ydeP;;HELO_2483;ABC-type transport system periplasmic substrate-binding protein;-1.5983838345371564;-0.050931818792658845;-0.8425109909192336;-4.276081172542135;-2.677697338004978
HELO_2484;1.9747137247024316;9.979050204327843;36.623148926773155;12.275393991801826;21.559117699982767;37.92690139635612;0.256219532676074;0.5047229074076155;7.912843366367198;1.7361256427691536;1.838386847715866;4.42097221927717;HELO_2484;ABC-type transport system permease protein;COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS08145;G;;;;HELO_2484;ABC-type transport system permease protein;-1.8839305118000482;-0.04914690743004613;-0.7870568656936161;-3.7099447692531538;-1.8260142574531053
HELO_2485;2.0718477482325546;7.208382511588238;29.502198463399107;10.353278429735683;18.611093554042608;33.63917554521126;0.24734072539932112;0.262795736134293;5.7358378092670455;1.0127264513477003;0.7543563181193933;2.7683592826486714;HELO_2485;ABC-type transport system permease protein;COG0395;ABC-type glycerol-3-phosphate transport system, permease component;UgpE;HELO_RS08150;G;;;;HELO_2485;ABC-type transport system permease protein;-1.4179912495677482;-0.1834913630717212;-0.8207346072130113;-3.495225974750367;-2.0772347251826186
HELO_2486;6.418243511454293;17.142327280242537;47.95030450181749;18.73059154260292;29.020220585499988;51.4641641673501;0.2949893104636983;1.3025453097690767;6.14182417238387;0.8400439293451898;2.2018864264282105;6.701853350190326;HELO_2486;ABC-type transport system ATP-binding protein;COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS08155;G;;;7.5.2.-;HELO_2486;ABC-type transport system ATP-binding protein;-1.2902100035899746;-0.10001448690397385;-0.8053977434627599;-2.8221827895596405;-1.531972785969666
HELO_2487;7.35061071273605;15.19285361807961;35.58609489164575;13.935432010264213;23.028256018300226;31.81768597222298;0.3639836377002447;2.2593178522476105;3.0564096329554094;0.68721238175359;2.687350387763022;3.6654982193135024;HELO_2487;HAD superfamily hydrolase;COG0637;Beta-phosphoglucomutase, HAD superfamily;YcjU;HELO_RS08160;G;;;;HELO_2487;HAD superfamily hydrolase;-0.9554036333962213;0.1568219185386006;-0.44974157488372324;-1.974519899218329;-1.0191162658221078
HELO_2488;8.2386633823576;15.38229111276693;26.900589755732284;10.169971078978902;15.330811337056227;23.556515526032374;0.12249952391234772;1.894157496910211;2.073562099520724;1.6064592715274448;0.18105496868737325;1.7333712236498335;HELO_2488;sorbitol dehydrogenase;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS08165;I;;;1.1.99.21;HELO_2488;sorbitol dehydrogenase;-0.826381088579589;0.18418975528595816;-0.5885093946759312;-1.4103498146627884;-0.5839687260831994
HELO_2489;12.84895699381554;23.734817921584227;43.039684780219254;21.153097514700935;23.493502066783787;43.05971385693362;1.1988063782092846;1.0921581036005905;3.532489167841201;2.9287872720797608;0.7867610967838162;5.629299208682764;HELO_2489;YggC family protein;COG1072;Pantothenate kinase;CoaA;HELO_RS08170;H;;;;HELO_2489;YggC family protein;-0.8367659528344076;-0.0006559829146226548;-0.8470610612222984;-1.6696827988693395;-0.8329168460349319
HELO_2490;10.969150728087605;14.385365844548991;28.11706284780061;16.39751309619851;22.47911059538498;30.232738388351706;0.5702140082304581;0.59619557949111;2.7842028983727225;1.1750227995673752;0.7003458367356733;2.922667255893865;mtlD;mannitol 2-dehydrogenase;COG0246;Mannitol-1-phosphate/altronate dehydrogenases;MtlD;HELO_RS08175;G;mtlD; mannitol 2-dehydrogenase;1.1.1.67;mtlD;mannitol 2-dehydrogenase;-0.36223796015630283;-0.10119423329593236;-0.41168130665388425;-1.38373827648424;-1.0215003163279373
HELO_2491;48.94205330421931;46.552971530078004;94.85958581975645;97.89082618100095;100.59806062707464;85.46039285133209;2.479856319867765;3.7155104942712693;6.203335361470182;6.028791529844759;4.878194387770402;4.000341035193859;xylB;xylulose kinase;COG1070;Sugar (pentulose or hexulose) kinase;XylB;HELO_RS08180;G;xylB; xylulose kinase;2.7.1.17;xylB;xylulose kinase;0.07071964081968396;0.148883315078983;0.23276156667254977;-0.7917842543794933;-0.8625038951991773
HELO_2492;29.195065915139537;29.45441941692747;47.351924365581134;42.61325657444665;59.28823199193415;46.08858013615055;1.1654642404512896;0.6878594871393726;4.059325029651048;5.551954049121853;1.8386791496927102;1.3034809308038464;talA4;transaldolase;COG0176;Transaldolase/fructose-6-phosphate aldolase;TalA;HELO_RS08185;G;talA4; transaldolase;2.2.1.2;talA4;transaldolase;-0.012338778790322635;0.03819608723205192;0.3564991999802265;-0.6410643992975436;-0.6287256205072209
HELO_2493;49.98129134034391;12.769034041664488;52.24687595424901;49.682818570011314;53.908494538386115;41.915040099810206;4.864755016136932;1.9752620117973365;5.796423982115603;1.5169041059043409;4.245927626105112;3.0544564752244536;HELO_2493;uncharacterized protein;;;;;;;;;HELO_2493;uncharacterized protein;1.8885405652256648;0.3112135370699791;0.35554601008684905;0.2484845704051546;-1.6400559948205102
HELO_2494;24.889706436602093;18.909372023957136;15.858402700406673;14.873627319054895;16.35811153930126;14.701961281498257;3.089208942735884;0.8617801260152652;1.360397651697796;1.369635057467481;0.9764049108575251;1.9698026284304997;HELO_2494;RND family transport protein MFP component;COG1566;Multidrug resistance efflux pump EmrA;EmrA;HELO_RS08195;V;;;;HELO_2494;RND family transport protein MFP component;0.37893088993260715;0.10252307754405265;0.14466522679227634;0.7214338338397228;0.34250294390711566
HELO_2495;14.350718339375073;11.964525310210368;7.315283283357718;7.384305123873067;5.884141854685386;7.536676953713662;0.05696060080612749;0.4954067810406272;1.1120351310096357;0.762229016843288;0.8526776851156527;0.5451113531627091;HELO_2495;DUF2955 domain protein;;;;;;;;;HELO_2495;DUF2955 domain protein;0.24373678474457705;-0.03790917182233544;-0.3103977597388763;0.8465596776033104;0.6028228928587334
HELO_2496;20.292345805305192;11.716044308911814;11.194280864018962;12.555667726204716;9.819476256357815;8.889333750818636;3.3286585117868026;0.891259770564448;0.8000768701996637;1.4065333384732308;1.8311674451280175;0.19748382288996327;HELO_2496;homolog to phage protein HAPgp19;;;;;;;;;HELO_2496;homolog to phage protein HAPgp19;0.7436849534751624;0.3022594459632515;0.1296854293047871;1.1063896678162695;0.36270471434110707
HELO_2497;72.51226833040762;19.36741324670739;28.161659818144162;50.53514214489721;45.88598449341698;26.24914754156153;3.5508732056872057;3.35194303661567;4.778912756618987;2.76144694029372;1.437469236616855;4.298088715684085;HELO_2497;YqaC family protein;COG0563;Adenylate kinase or related kinase;Adk;HELO_RS08215;F;;;;HELO_2497;YqaC family protein;1.8517222756609355;0.09786173953047861;0.7829456285430085;1.4317739412957726;-0.4199483343651629
HELO_2498;67.52209485758117;13.757201976393922;34.6253801772799;52.46652937050888;51.722400057612305;31.200409486742085;1.146038556068207;0.2714644089247655;2.608336792682808;1.0897533592170743;4.0105538990784035;4.100769824124517;pka1;protein lysine acetyltransferase Pka;COG1670;Protein N-acetyltransferase, RimJ/RimL family;RimL;HELO_RS08220;JO;pka1; protein lysine acetyltransferase Pka;;pka1;protein lysine acetyltransferase Pka;2.2151500515045828;0.1458263750623532;0.7113370120382534;1.0894902232243737;-1.125659828280209
HELO_2499;243.63454711589657;79.83057905584461;186.37266757974808;387.45705212352715;303.82775268276845;197.14609366737216;13.114005260667174;2.040473881859903;5.984117280919326;13.779324865223668;3.8820644348406432;14.95727583170519;HELO_2499;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG1063;Threonine dehydrogenase or related Zn-dependent dehydrogenase;Tdh;HELO_RS08225;ER;;pka1;1.1.1.-;HELO_2499;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);1.5976550665951752;-0.08065400613348395;0.6214297315673081;0.30406362890512106;-1.2935914376900541
HELO_2500;20.196682076820704;8.905344843889258;9.824929661302543;13.786194245182953;12.915233890996218;7.5308754409436665;2.2747424238140472;1.7225526721007258;1.3561916469043036;2.867905896975204;0.9438566863246075;2.1490519558899903;HELO_2500;CidA family protein;COG1380;Putative effector of murein hydrolase LrgA, UPF0299 family;YohJ;HELO_RS08235;R;;;;HELO_2500;CidA family protein;1.0975593499890879;0.34359194653398406;0.7058994540377705;1.3130727529193789;0.21551340293029098
HELO_2501;25.35083469413318;16.791707697294328;21.14396320170787;30.847893230378343;31.385391971577416;21.04586973697091;0.4142788679363477;0.21683164726778106;0.7166998125150611;1.807775323245496;3.65898054360059;2.6045907229297245;HELO_2501;CidB family protein;COG1346;Putative effector of murein hydrolase;LrgB;HELO_RS08240;M;;;;HELO_2501;CidB family protein;0.5666436705635096;0.006405056464743097;0.5548348114338255;0.2573402674837961;-0.3093034030797135
HELO_2502;29.746194671951134;8.594361869848393;44.12981348489681;102.73052829218165;77.10206587130519;41.020039275451445;1.4376769518892547;0.2997413050727615;3.6907407983402685;1.9151068314584048;17.375946932621016;6.1208578634464015;ctaC;cytochrome c oxidase subunit 2;COG2010;Cytochrome c, mono- and diheme variants;CccA;HELO_RS08250;C;ctaC; cytochrome c oxidase subunit 2;7.1.1.9;ctaC;cytochrome c oxidase subunit 2;1.6801491054612083;0.10300330563389704;0.8942831990042155;-0.4506696453120229;-2.1308187507732312
HELO_2503;8.68209894780035;3.4387555555774845;11.448012902217606;24.400624967299052;21.404726497372053;10.393943448172509;0.2997887813414219;0.44199086923330777;1.8167291172269626;1.7033336344930654;1.8901149664905654;1.0486239382216729;ctaD;cytochrome c oxidase subunit 1;COG0843;Heme/copper-type cytochrome/quinol oxidase, subunit 1;CyoB;HELO_RS08255;C;ctaD; cytochrome c oxidase subunit 1;7.1.1.9;ctaD;cytochrome c oxidase subunit 1;1.1251645771984453;0.12764830999705445;0.9755359643191883;-0.23487540753108815;-1.3600399847295335
HELO_2504;9.46287621929592;4.804367738677635;5.44724552742224;9.084216175374879;10.035590784473348;4.381521632679758;0.9013243013589561;0.05382780679238801;0.8584461252907188;0.6301955661383931;0.47317876039250356;1.2058913998099516;ctaG;cytochrome c oxidase assembly protein CtaG;COG3175;Cytochrome c oxidase assembly protein Cox11;COX11;HELO_RS08260;OC;ctaG; cytochrome c oxidase assembly protein CtaG;;ctaG;cytochrome c oxidase assembly protein CtaG;0.8500686693809665;0.26066877153028134;1.0360778060025502;0.9591934398809419;0.10912477049997538
HELO_2505;8.082318616846724;3.8746564691675265;17.319749574005243;37.33655424321805;37.44131346608264;15.025351532447308;1.520906762366045;0.17483833313039426;2.9237432081110435;1.0138604750775688;1.2852462485096552;0.40624394793230967;ctaE;cytochrome c oxidase subunit 3;COG1845;Heme/copper-type cytochrome/quinol oxidase, subunit 3;CyoC;HELO_RS08265;C;ctaE; cytochrome c oxidase subunit 3;7.1.1.9;ctaE;cytochrome c oxidase subunit 3;0.8977600971956083;0.19304377814096974;1.2623016269014355;-0.8192234502280784;-1.7169835474236868
HELO_2506;15.41576928027765;5.969981879191202;34.131483780168395;46.10309069610835;33.451917262640364;30.414031384178983;4.209642298732426;0.46093113271148245;4.880171050168166;13.047755411903388;6.800021980940504;6.973272406556544;HELO_2506;DUF2909 domain protein;;;;;;;;;HELO_2506;DUF2909 domain protein;1.2358555490244378;0.16135541323819869;0.13317517479163854;-0.9363267374486757;-2.1721822864731135
HELO_2507;20.44411848082326;7.928421368614508;24.315251626771754;47.82189833541123;51.810853697002976;21.173648791663165;0.5528346430464913;1.0659534381152151;3.204173541661878;5.227912177064359;3.7692546832389384;1.4628062723293465;HELO_2507;SURF1 domain protein;COG3346;Cytochrome oxidase assembly protein ShyY1;Shy1;HELO_RS08275;O;;;;HELO_2507;SURF1 domain protein;1.2641049907157655;0.19116063144766304;1.2519882701533227;-0.04826418160634205;-1.3123691723221076
HELO_2508;17.11002791992699;6.8281231715417325;18.076844197219824;33.49154044939697;34.749565377362565;15.048535460919696;2.2523954551209755;0.7029162369940202;1.7197230424543668;4.4664226580936734;4.475424022736177;0.867489676464111;HELO_2508;uncharacterized protein;;;;;;;;;HELO_2508;uncharacterized protein;1.2100504091390167;0.24938088453351082;1.1554840550180732;0.17434712294488008;-1.0357032861941367
HELO_2509;9.416112328663157;5.149170477381593;11.149386531458942;22.05171633922984;20.576982624349068;9.304721203972433;0.9712388389455637;0.616371267250666;1.7045737705265431;1.8116342568825103;1.567716804672513;1.5302370385052853;ctaA;heme A synthase;COG1612;Heme A synthase;CtaA;HELO_RS08285;H;ctaA; heme A synthase;1.17.99.9;ctaA;heme A synthase;0.7603532026627651;0.23757799549394054;1.0661876560472718;0.015511438865056348;-0.7448417637977087
HELO_2510;10.93465925976687;3.52345950986901;13.600141137556099;23.653063505252543;24.926142112049074;14.471395923879792;0.9011969698760097;0.29995275379002323;1.177736683875836;1.5379292398043463;1.7086692470981477;1.2614453747300216;cyoE2;protoheme IX farnesyltransferase;COG0109;Polyprenyltransferase (heme O synthase);CyoE;HELO_RS08290;HI;cyoE2; protoheme IX farnesyltransferase;2.5.1.141;cyoE2;protoheme IX farnesyltransferase;1.3996589145106597;-0.08362105591472035;0.744804173377247;-0.3744459940480773;-1.774104908558737
HELO_2511;128.54619583850146;105.40709500332302;119.60466696855242;116.74837314495151;114.59772079410097;130.3919121509553;1.248806913444633;3.196834958731887;9.780811677530128;5.9735131327826165;3.61405165905816;10.720101416026344;sdcS;DASS family transport protein (probable substrate dicarboxylate);COG0471;Di- and tricarboxylate antiporter;CitT;HELO_RS08295;G;sdcS; DASS family transport protein (probable substrate dicarboxylate);;sdcS;DASS family transport protein (probable substrate dicarboxylate);0.28387230103820027;-0.12359073763379147;-0.18476352015194664;-0.020409822098679697;-0.30428212313687997
HELO_2512;509.49002556375285;642.696584312096;374.29102731608145;518.2889029079275;385.207342171933;429.07526822171076;44.458270726763665;69.40050968549032;26.073536589614633;29.672973916531305;49.03545451367297;7.592858513375417;HELO_2512;DUF2489 family protein;;;;;;;;;HELO_2512;DUF2489 family protein;-0.3344980407637639;-0.19657937266800118;-0.15521357891775978;0.2472936021569634;0.5817916429207273
HELO_2513;16440.33232884196;8550.398899631537;19938.14119699829;22190.676459977723;23570.6619786087;19280.76203086928;576.4427241894421;654.2674326066716;793.1720080546709;645.0767195994819;2933.463003758659;773.5245630813029;HELO_2513;OmpA/MotB domain protein;COG2885;Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins;OmpA;HELO_RS08305;M;;;;HELO_2513;OmpA/MotB domain protein;0.943094862131943;0.04836637663577292;0.28981658716077874;-0.2299096827828393;-1.1730045449147823
HELO_2514;487.0493755119173;643.6038016596721;713.9022432485377;843.1465227587656;654.2846874826114;703.1858357610528;27.60136380312363;39.4488754524446;9.426003580284398;13.87828904870216;29.96741584706612;42.88118771261458;thrS;threonine--tRNA ligase;COG0441;Threonyl-tRNA synthetase;ThrS;HELO_RS08310;J;thrS; threonine--tRNA ligase;6.1.1.3;thrS;threonine--tRNA ligase;-0.40138558564159865;0.021789770579211165;-0.10383438901287256;-0.5289290973044452;-0.1275435116628465
HELO_2515;7389.591508149162;6999.614032076594;4728.599319415083;4785.031927812823;3626.3117750214988;3851.536710532215;263.03646796496923;358.8634795502374;307.69764172945304;529.50379883491;75.12001526967421;132.50232627131678;infC;translation initiation factor IF-3;COG0290;Translation initiation factor IF-3;InfC;HELO_RS08315;J;infC; translation initiation factor IF-3;;infC;translation initiation factor IF-3;0.07820836742776116;0.2959092628562807;-0.08690795084897296;0.9398811313732196;0.8616727639454584
HELO_2516;12605.429647395113;15279.781841024953;3196.06272825764;3130.337189721177;2972.9069664128056;3482.5102077888864;1250.5131031379992;956.3484710461249;902.2019385626352;488.0612368577256;1087.845006552552;982.3159977138683;rpmI;50S ribosomal protein L35;COG0291;Ribosomal protein L35;RpmI;HELO_RS08320;J;rpmI; 50S ribosomal protein L35;;rpmI;50S ribosomal protein L35;-0.2775586226873905;-0.12379473992743328;-0.2281822749995026;1.8555460420852992;2.1331046647726897
HELO_2517;5231.6470166462195;4347.983589059442;2082.481901920063;2268.211112519713;1781.1238513240999;1848.0234547420387;362.6435659462568;368.342844453098;200.11562939116163;25.427805551350403;156.2872588887507;235.31042221188025;rplT;50S ribosomal protein L20;COG0292;Ribosomal protein L20;RplT;HELO_RS08325;J;rplT; 50S ribosomal protein L20;;rplT;50S ribosomal protein L20;0.2668626762786239;0.17223304283292862;-0.05316592278827237;1.5007774157134612;1.2339147394348373
HELO_2518;490.4125441574449;671.9094269505833;803.3067826168932;780.7069102511978;736.3011808678392;809.0268940695472;48.461313216306834;32.33441555746346;30.226156515981607;8.061728753787031;22.5822674164643;42.619697317674195;pheS;phenylalanine--tRNA ligase alpha subunit;COG0016;Phenylalanyl-tRNA synthetase alpha subunit;PheS;HELO_RS08330;J;pheS; phenylalanine--tRNA ligase alpha subunit;6.1.1.20;pheS;phenylalanine--tRNA ligase alpha subunit;-0.45347764688686176;-0.01022392220661672;-0.13571574075928083;-0.7210351229003926;-0.26755747601353086
HELO_2519;382.7313520193763;409.16915325559586;563.535719873298;586.7571413316191;561.6813986240011;575.9663639105914;11.468509757790743;18.242501968439925;41.44447801296298;21.285084918746023;41.61312875531993;28.096309734294213;pheT;phenylalanine--tRNA ligase beta subunit;COG0073;tRNA-binding EMAP/Myf domain;EMAP;HELO_RS08335;J;pheT; phenylalanine--tRNA ligase beta subunit;6.1.1.20;pheT;phenylalanine--tRNA ligase beta subunit;-0.0961223557789026;-0.03142234728432136;-0.036168943906885076;-0.5883905724938963;-0.49226821671499366
HELO_2520;668.466530567543;585.6085034180006;360.981812968166;316.4103179841384;314.3544089963017;377.32744782672256;9.21024238028306;9.671677704956648;25.916168276817043;9.995013287755016;10.368049236548515;47.91808734217084;ihfA;HU-type DNA-binding protein IhfA;COG0776;Bacterial nucleoid DNA-binding protein IHF-alpha;HimA;HELO_RS08340;L;ihfA; HU-type DNA-binding protein IhfA;;ihfA;HU-type DNA-binding protein IhfA;0.19061394658313446;-0.06371823447557823;-0.2626613445694925;0.8233764826328436;0.6327625360497091
HELO_2521;31.843238085773038;11.804103075704617;17.20239321011314;33.99966084203087;36.57837498150619;18.03520719636975;3.4469334889073786;0.994782586876685;1.36435325196476;2.2809923521443416;2.4149353667403797;0.6365896552521791;HELO_2521;uncharacterized protein;;;;;;;;;HELO_2521;uncharacterized protein;1.358990176508438;-0.06454212835522721;0.9812324074191272;0.7869260989676379;-0.5720640775408001
HELO_2522;142.09209757458873;222.54312024958946;230.2683992218713;221.60216323771945;211.1704936423175;197.08954390785323;13.510276288267836;27.109957540667672;13.292926507382969;15.570166305367872;5.597459625351262;18.109529760095658;HELO_2522;flavodoxin family protein;COG0369;Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases;CysJ;HELO_RS08350;FP;;;;HELO_2522;flavodoxin family protein;-0.6436091464887097;0.22341541789471275;0.09907130586584412;-0.46920873027448806;0.17440041621422164
HELO_2523;214.83576628188493;353.54263131226577;109.49915424706968;113.3138890441553;108.57172633361563;108.0252566481998;4.831136108981965;29.30875282741573;3.2605253414705944;0.17239090715295083;4.792256428636032;8.62585621069444;HELO_2523;uncharacterized protein;;;;;;;;;HELO_2523;uncharacterized protein;-0.7160251575008507;0.0193729408063259;0.007213189649170282;0.985271567983685;1.7012967254845357
HELO_2524;148.0483869078788;73.79749710482206;196.06896236129685;175.31271057110607;224.27638057121396;196.62852216223393;3.709757140242266;2.9603484422829927;15.656824715967861;2.804295536331061;29.383189456482707;23.388506536274136;ygdH;LOG family protein YgdH;COG1611;Nucleotide monophosphate nucleosidase PpnN/YdgH, Lonely Guy (LOG) family;PpnN;HELO_RS08360;F;ygdH; LOG family protein YgdH;3.2.2.10,3.2.2.-;ygdH;LOG family protein YgdH;0.9947188615316938;-0.004090599623162383;0.1889048853300519;-0.40701041302671825;-1.401729274558412
HELO_2525;108.18056824168347;89.79745281140816;98.33944838724041;128.6253079699948;143.81462339161916;92.04196163588159;4.80488839471888;4.691327395659965;5.165576868404687;4.190699726281394;1.1284001760361033;5.210492687754989;HELO_2525;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS08365;K;;ygdH;;HELO_2525;LysR family transcription regulator;0.26599238035825046;0.09448522181994701;0.6382538741481625;0.23076269179037645;-0.03522968856787401
HELO_2526;112.81449282776505;206.6521972498305;155.93442155328543;181.944446624536;243.84636852810954;166.33526705618837;11.637455832936027;6.27948789613354;12.806372293676375;12.355444804780944;8.84679879163457;13.720485239583516;gcvP;glycine dehydrogenase (decarboxylating);COG1003;Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain;GcvP2;HELO_RS08370;E;gcvP; glycine dehydrogenase (decarboxylating);1.4.4.2;gcvP;glycine dehydrogenase (decarboxylating);-0.8674848593668099;-0.09257971163058087;0.5491352633745432;-0.556057257102891;0.31142760226391886
HELO_2527;258.87392610690205;238.24495984071095;354.94879715540145;376.0951471627563;440.06502181302335;331.7072408059787;25.41579848706561;14.623047980811704;26.227496969117567;35.4512543337078;24.184323260954212;26.58073518310477;gcvH;glycine cleavage system protein GcvH;COG0509;Glycine cleavage system protein H (lipoate-binding);GcvH;HELO_RS08375;E;gcvH; glycine cleavage system protein GcvH;;gcvH;glycine cleavage system protein GcvH;0.11932335949688877;0.09741646165443107;0.40673808922776544;-0.35644137300284306;-0.47576473249973183
HELO_2528;247.15884221607928;460.91658671567234;621.0548517760332;573.0866929208372;553.4355995765831;650.1964849337033;7.559606168399309;5.8811888089984405;43.27824085941697;7.955754441201333;13.480908250565868;53.87501742512863;HELO_2528;SAF family transport protein (probable substrate alanine);COG1115;Na+/alanine symporter;AlsT;HELO_RS08380;E;;gcvH;;HELO_2528;SAF family transport protein (probable substrate alanine);-0.8963684914663794;-0.06605111171567657;-0.23207301817215864;-1.391829051546539;-0.4954605600801596
HELO_2529;328.06068284800034;436.973718762501;446.08210698823797;364.1909028408956;414.92101429389203;468.0575574954646;10.83069114974877;33.679194040931236;35.478031804138055;7.990019294569734;21.29978122531572;22.24616129150812;gcvT;glycine cleavage system protein GcvT (aminomethyltransferase);COG0404;Glycine cleavage system protein T (aminomethyltransferase);GcvT;HELO_RS08385;E;gcvT; glycine cleavage system protein GcvT (aminomethyltransferase);2.1.2.10;gcvT;glycine cleavage system protein GcvT (aminomethyltransferase);-0.4124906421983159;-0.06922515715264232;-0.17345538640464397;-0.5114113057448275;-0.09892066354651163
HELO_2530;13.349421278599939;9.408250738497577;13.802784450289545;19.11795004496877;17.823181180081704;16.614880554279274;0.5947328261806664;0.39433318911971343;1.2376494661752637;2.850343778189451;3.713348706102458;3.275373575322716;alkB;alkylated DNA repair protein AlkB;COG3145;Alkylated DNA repair dioxygenase AlkB;AlkB;HELO_RS08390;L;alkB; alkylated DNA repair protein AlkB;;alkB;alkylated DNA repair protein AlkB;0.46326493062572016;-0.25092611516200636;0.0957157769060828;-0.2958021387609433;-0.7590670693866635
HELO_2531;1.8281706776483135;1.1801861773813618;0.47626114171436945;0.5312919543040623;0.4413744630542061;0.5946020533479284;0.42667227937326074;0.12278220130619638;0.28662564634038623;0.182590372883156;0.3349636646613108;0.101626651427039;HELO_2531;PAP2 domain protein;;;;;;;;;HELO_2531;PAP2 domain protein;0.3754178487103492;-0.11124848391066422;-0.14575124161431563;0.8266727562127048;0.45125490750235553
HELO_2532;25.612482920505204;16.120635960734507;9.387018476426846;11.840827808955458;11.553308735417945;9.02272852844669;1.481254785003458;0.6941098160230219;1.2242636071744222;0.4765750212205533;1.0829450838036525;1.722678424883071;HELO_2532;probable glycosyltransferase%2C type 1;COG0438;Glycosyltransferase involved in cell wall bisynthesis;RfaB;HELO_RS08400;M;;;;HELO_2532;probable glycosyltransferase%2C type 1;0.6363668258962862;0.051506285003546814;0.32479235952243535;1.4088278059936283;0.7724609800973421
HELO_2533;112.06981317224479;57.030417064017;71.57386897798663;86.26826649270191;90.4621367080121;69.58237369088346;2.5526487773866284;1.8399991138658855;7.6559599837187635;3.566085319784731;8.521635808669004;6.409258142172426;HELO_2533;peptidase M23 family protein;COG4942;Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB;EnvC;HELO_RS08405;D;;;;HELO_2533;peptidase M23 family protein;0.9623326143653363;0.04014223457123833;0.37386667441686683;0.6798339630451196;-0.2824986513202168
HELO_2534;57.634529619087594;32.43717793718866;40.27014600457928;37.124655539128476;43.80445855697391;39.357917883357906;1.328889907258146;2.4708016300093316;2.6474850150244618;2.11818328152195;3.4450355645753494;0.9232802886401658;yihG;probable acyltransferase YihG;COG0204;1-acyl-sn-glycerol-3-phosphate acyltransferase;PlsC;HELO_RS08410;I;yihG; probable acyltransferase YihG;;yihG;probable acyltransferase YihG;0.8102974211273306;0.03224679640715333;0.15079055823241472;0.5388987658527205;-0.27139865527461016
HELO_2535;31.84659322559517;23.647517222002637;33.44188237330476;32.52800562792883;41.452544009045404;36.105500198787894;1.7139026981861722;1.5323711034719643;3.769378439093331;2.8196332338107752;3.8814807488152154;3.483405482826045;HELO_2535;acetoacetate--CoA ligase;COG0365;Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase;Acs;HELO_RS08415;I;;yihG;6.2.1.16;HELO_2535;acetoacetate--CoA ligase;0.4143014159535978;-0.10746906196089423;0.19421795589366297;-0.17588931010840714;-0.590190726062005
HELO_2536;23.07427342902227;14.3341746107187;21.26448193634242;14.685948580972756;15.575558842834171;21.74056391363845;0.6258445191755884;1.5508200047176115;1.9452137251098123;1.8012749912563537;0.5709438947475288;1.3548529306099881;HELO_2536;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS08420;K;;;;HELO_2536;LysR family transcription regulator;0.6507417445630992;-0.03052398753386143;-0.4562105187542578;0.08222422743596969;-0.5685175171271295
HELO_2537;3.402256826401731;2.0334969105199825;3.899341891621534;3.0980851378735257;11.132089818521786;3.9320868557094215;0.6065497066553782;0.15981718951907659;0.6584923304529429;0.5930306194266528;0.7313385943842174;1.2075674282307576;scoA;succinyl-CoA:3-ketoacyl-CoA transferase subunit ScoA;COG1788;Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit;AtoD;HELO_RS08425;I;scoA; succinyl-CoA:3-ketoacyl-CoA transferase subunit ScoA;2.8.3.5;scoA;succinyl-CoA:3-ketoacyl-CoA transferase subunit ScoA;0.537261472048314;-0.009610235338754158;1.2985579725175875;-0.16395489220971937;-0.7012163642580334
HELO_2538;6.357735250446645;3.5829181801172;8.580383979331996;8.508998320018264;18.8954560541311;8.831570976513703;0.28244322388530013;0.15796346755395094;1.1081210260600607;1.2313283051862616;1.8296150078337496;1.3517542873572592;scoB;succinyl-CoA:3-ketoacyl-CoA transferase subunit ScoB;COG2057;Acyl-CoA:acetate/3-ketoacid CoA transferase, beta subunit;AtoA;HELO_RS08430;I;scoB; succinyl-CoA:3-ketoacyl-CoA transferase subunit ScoB;2.8.3.5;scoB;succinyl-CoA:3-ketoacyl-CoA transferase subunit ScoB;0.6829952363222005;-0.03733848176024601;1.0169451027866518;-0.4181601962266406;-1.101155432548841
HELO_2539;40.55803357041055;42.895360378797925;45.756991085057365;70.9595318112822;46.71857533010982;43.59549842124841;1.1450572381586244;3.5330893455939525;3.3538103035305884;10.364325721377275;6.717017028841926;6.168489527623913;HELO_2539;DUF1338 family protein;;;;;;;;;HELO_2539;DUF1338 family protein;-0.07894106796428968;0.06828400393915057;0.09765288272656925;-0.1017706974470789;-0.022829629482789215
HELO_2540;498.844811465272;445.1912070318672;572.8531965006106;276.7365512499136;592.7227777077313;482.9854002323209;21.585661638125167;28.382865493990337;22.61598636284267;16.789619176953284;57.925684087340244;38.289535644420184;grxA;glutaredoxin;COG0695;Glutaredoxin;GrxC;HELO_RS08440;O;grxA; glutaredoxin;;grxA;glutaredoxin;0.16381816285839612;0.24571818469088313;0.2948259338068855;0.046516717701061694;-0.11730144515733443
HELO_2541;49.63428191756745;37.05012231473052;83.51926905242588;85.03900878143757;101.8084938146286;87.62544327604006;0.16854295616526624;2.1015030053419577;6.070182289175528;1.652804696253202;9.157564115375262;3.000219447938208;HELO_2541;homolog to inositol monophosphatase;COG0483;Archaeal fructose-1,6-bisphosphatase or related enzyme, inositol monophosphatase family;SuhB;HELO_RS08445;G;;grxA;3.1.3.25;HELO_2541;homolog to inositol monophosphatase;0.41221340037523024;-0.06844064779358039;0.2141666184082167;-0.8076064465142778;-1.219819846889508
HELO_2542;76.08827654437992;49.20873348649783;77.61628774477323;82.09153924084977;99.23636012481766;76.68834904039012;0.1559534224976685;1.6832083817274555;3.619813817476125;2.393908244914448;5.604128588131879;3.9991371511229636;bdh;3-hydroxybutyrate dehydrogenase;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS08450;I;bdh; 3-hydroxybutyrate dehydrogenase;1.1.1.30;bdh;3-hydroxybutyrate dehydrogenase;0.6185731406490529;0.017129988242323257;0.36763577396152947;-0.011186778992990476;-0.6297599196420434
HELO_2543;83.60760445943158;47.85949367145499;68.91553541000324;72.32069782122021;98.59175999884938;68.2950824776102;2.6434977081961955;3.956281058950056;6.483595943665744;1.9647317760383525;7.468460874562012;3.8425964939437933;yjjV;TatD-type hydrolase YjjV;COG0084;3'->5' ssDNA/RNA exonuclease TatD;TatD;HELO_RS08455;N;yjjV; TatD-type hydrolase YjjV;3.1.21.-;yjjV;TatD-type hydrolase YjjV;0.792148424269957;0.01286008652678916;0.5232734066390776;0.2880343621675907;-0.5041140621023663
HELO_2544;171.7095855001135;93.3810901258167;162.4765955699395;305.62051685182195;174.1398391805467;159.7577061618592;12.889653476439388;2.5720121558061937;8.879002104669091;21.76736339227606;7.932239100651717;12.680899899024178;ygfZ;tRNA-modifying protein YgfZ;COG0354;Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters;YgfZ;HELO_RS08460;O;ygfZ; tRNA-modifying protein YgfZ;;ygfZ;tRNA-modifying protein YgfZ;0.8717784154686896;0.024196207433046624;0.12361939497974372;0.10346025868795916;-0.7683181567807305
HELO_2545;258.7457301884042;208.2238667183516;302.9756516768659;364.8588188997005;328.5244845196094;293.1047066965989;19.036430952796323;5.764964930636936;30.700636237959994;17.145537597535572;11.05856531607107;9.13416382073377;HELO_2545;OsmC domain protein;COG1765;Uncharacterized OsmC-related protein;YhfA;HELO_RS08470;R;;ygfZ;;HELO_2545;OsmC domain protein;0.3120526006843338;0.04762589648445115;0.16405579264051617;-0.17922983885497068;-0.4912824395393045
HELO_2546;168.5570217941499;98.83402054061709;107.72459795401265;143.228120752694;145.2293298757048;112.9048069394309;1.4134362154665565;3.9634746567174797;6.728288442717832;4.610267388269086;1.6472068138317115;0.9801181268436484;uvrB;UvrABC system protein UvrB;COG0556;Excinuclease UvrABC helicase subunit UvrB;UvrB;HELO_RS08475;L;uvrB; UvrABC system protein UvrB;;uvrB;UvrABC system protein UvrB;0.7641670982123063;-0.0671502580858574;0.3604040761156213;0.5739418992832022;-0.19022519892910417
HELO_2547;530.7504301931784;741.5737629814699;692.1174056632261;798.8946570669377;883.993665506689;654.776123688624;5.021956214936073;37.348752950240666;90.19427032120606;13.7111250911109;33.12593878921569;152.5469248779251;fumA;fumarate hydratase%2C class I;COG1951;Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain;TtdA;HELO_RS08480;C;fumA; fumarate hydratase, class I;4.2.1.2;fumA;fumarate hydratase%2C class I;-0.4817850466643794;0.07989637281015582;0.4324637536416578;-0.3024540799088591;0.1793309667555203
HELO_2548;132.97145596086685;72.17787703415893;84.78430982333931;116.60699037164092;110.8574489539909;80.46338713288576;5.087548344041094;0.3058516365560987;6.9203477790601164;2.7396851923515615;17.01142350322229;16.518435719763662;clsA;cardiolipin synthase;COG1502;Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase;Cls;HELO_RS08485;I;clsA; cardiolipin synthase;2.7.8.-;clsA;cardiolipin synthase;0.8724461846265132;0.07456199830698385;0.4574376274567715;0.7177019460204761;-0.15474423860603714
HELO_2549;183.6730799111067;54.84221103903162;73.33705085718013;84.42798225669947;82.39835546865196;72.30619822715207;3.8659511117364826;1.4168649313100914;1.3489987217453332;1.0144468464475076;5.021698605902383;4.324431749239422;HELO_2549;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS08490;K;;clsA;;HELO_2549;LysR family transcription regulator;1.725545607253319;0.02014626681240994;0.1860837483773352;1.332966485497419;-0.39257912175590004
HELO_2550;51.47477047140043;37.09807701040507;36.337001020932966;40.02437326874008;42.89044990466789;35.39318193349496;0.5391580012653802;1.352124791447244;1.9713012070443354;1.4430536210988993;0.7779896106285635;2.5448044728900316;nadM;nicotinamide-nucleotide adenylyltransferase / ADP-ribose diphosphatase;COG1056;Nicotinamide mononucleotide adenylyltransferase;NadR;HELO_RS08495;H;nadM; nicotinamide-nucleotide adenylyltransferase / ADP-ribose diphosphatase;2.7.7.1,3.6.1.-;nadM;nicotinamide-nucleotide adenylyltransferase / ADP-ribose diphosphatase;0.46190577113973585;0.03693785760527035;0.2702388642055773;0.5279557564766959;0.06604998533696005
HELO_2551;129.07357442812886;77.81876658769414;143.6865643280748;222.8061423148429;146.6984113854054;145.42954031610296;7.478297791318531;3.807401857326582;9.48332369271826;3.712915561812381;10.90991965774753;15.196955513851638;HELO_2551;BrkB family protein;COG1295;Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase);BrkB;HELO_RS08500;S;;nadM;;HELO_2551;BrkB family protein;0.7227168174028069;-0.017275669888587863;0.012447680303423247;-0.17087873269689347;-0.8935955500997004
HELO_2552;24.59592996229077;18.581290812112396;15.35881789061546;19.3645461111254;24.426055242258116;14.277161148133631;0.31040216791289116;0.3359734115239762;1.8702194176181326;0.866131273257057;1.6191870899017895;1.1338236271245392;ldh;leucine dehydrogenase;COG0334;Glutamate dehydrogenase/leucine dehydrogenase;GdhA;HELO_RS08505;E;ldh; leucine dehydrogenase;1.4.1.9;ldh;leucine dehydrogenase;0.38643855237331337;0.09869201904723068;0.7349311686434485;0.7445379419104188;0.3580993895371054
HELO_2553;57.104803550325904;41.152115575469786;54.188667945140196;75.23028135876267;51.60556034898835;32.949293433275756;2.4707400539599194;3.3573468090257816;19.329859460799973;36.94319785714207;7.979070684356284;5.801918867779463;acyP;acylphosphatase;COG1254;Acylphosphatase;AcyP;HELO_RS08510;C;acyP; acylphosphatase;3.6.1.7;acyP;acylphosphatase;0.46305239630349515;0.700990515691827;0.6318337500150157;0.775275887992934;0.31222349168943886
HELO_2554;380.62129353351975;211.86292249362745;437.0101992580632;328.75446493902797;513.2884650049818;466.0499598602676;9.1886102048959;11.561936016114364;30.636944603749416;6.666699426993117;40.20163547602009;11.196330715650406;HELO_2554;probable nucleoside hydrolase;COG1957;Inosine-uridine nucleoside N-ribohydrolase;URH1;HELO_RS08515;F;;acyP;;HELO_2554;probable nucleoside hydrolase;0.8422169964536348;-0.09261241781469032;0.13900091397877645;-0.29143520937480716;-1.133652205828442
HELO_2555;184.52197602017532;95.19404046579358;179.15999294506653;172.0753338018501;207.8328773144245;184.11624715842095;8.992018381279717;3.8134454455745166;12.427278756263517;9.715673686756052;14.75845106025271;5.834340724505091;rbsK;probable ribokinase;COG0524;Sugar or nucleoside kinase, ribokinase family;RbsK;HELO_RS08520;G;rbsK; probable ribokinase;2.7.1.15;rbsK;probable ribokinase;0.9475706693039676;-0.03915284621868498;0.17391733622692573;0.0031585692678293142;-0.9444121000361383
HELO_2556;71.87806787818663;91.55435229827107;130.7047392029693;128.82778654202716;157.9771221327935;133.896183391121;5.106662123585419;3.101620119129802;5.287157912641524;9.212622457949307;12.661131620230305;7.183313028937604;HELO_2556;probable 2-hydroxyacid dehydrogenase;COG1052;Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase;LdhA;HELO_RS08525;CHR;;rbsK;1.1.1.29;HELO_2556;probable 2-hydroxyacid dehydrogenase;-0.3448161219897994;-0.03454227098176599;0.23696963622967893;-0.8882929143325908;-0.5434767923427914
HELO_2557;343.62797579333557;242.22537111414817;272.2833521769639;304.35813161369254;249.66006727593125;257.9444901478683;22.143500176484785;46.198493981455314;23.428137168032368;18.38147737920665;2.6759927784393063;57.927204352015835;HELO_2557;FmdB domain protein;COG2331;Predicted nucleic acid-binding protein, contains Zn-ribbon domain;;HELO_RS08530;R;;;;HELO_2557;FmdB domain protein;0.5027460938852419;0.07775471576099768;-0.04691068262117959;0.4123969587150409;-0.09034913517020104
HELO_2558;494.41352756369787;410.59118855069636;569.1418584679762;547.703406336896;611.9453997029999;604.1613549942704;14.826854074706882;9.803399359476796;38.711933570769105;34.99915251084842;34.26825992131385;18.253153839178506;aspS;aspartate--tRNA(Asn) ligase;COG0173;Aspartyl-tRNA synthetase;AspS;HELO_RS08535;J;aspS; aspartate--tRNA(Asn) ligase;6.1.1.12;aspS;aspartate--tRNA(Asn) ligase;0.26742116579754516;-0.0859989367973455;0.018438705017327806;-0.28868659864136603;-0.5561077644389112
HELO_2559;103.42649882389465;156.69581781466658;143.73528744377896;178.07123323464498;143.4640104107507;120.76308409107348;10.671333099052882;12.512890168020727;3.96781027565236;16.23704625130461;4.240911939065019;15.376464370283605;HELO_2559;PmpR family transcription regulator;COG0217;Transcriptional and/or translational regulatory protein YebC/TACO1;TACO1;HELO_RS08540;JK;;aspS;;HELO_2559;PmpR family transcription regulator;-0.5946565490013622;0.24933989768761933;0.2466333202654134;-0.22158895537554368;0.37306759362581854
HELO_2560;154.57593470254733;179.7222942310584;148.61828321973445;167.09854072361605;164.7756230016487;141.559928355898;4.491813339066648;12.16114689075874;4.477453272741587;12.110926296491913;3.0203594968461887;9.293725288288426;ruvC;crossover junction endodeoxyribonuclease RuvC;COG0817;Holliday junction resolvasome RuvABC endonuclease subunit RuvC;RuvC;HELO_RS08545;L;ruvC; crossover junction endodeoxyribonuclease RuvC;3.1.22.4;ruvC;crossover junction endodeoxyribonuclease RuvC;-0.2161555766815999;0.06971796509526751;0.21766335985591834;0.12605039704466314;0.34220597372626305
HELO_2561;441.02773108841757;348.8799834277424;358.01540479141187;397.34933624489787;331.295938270477;365.8925938984619;20.004875263850003;6.453199435895778;22.796350321085562;22.424172736564806;14.221046095974362;19.618519510630584;ruvA;Holliday junction ATP-dependent DNA helicase RuvA;COG0632;Holliday junction resolvasome RuvABC DNA-binding subunit;RuvA;HELO_RS08550;L;ruvA; Holliday junction ATP-dependent DNA helicase RuvA;3.6.4.12;ruvA;Holliday junction ATP-dependent DNA helicase RuvA;0.33727675088241327;-0.03131203343635924;-0.1428891238631529;0.2687790988834635;-0.06849765199894975
HELO_2562;317.80117885733387;193.79234930397453;134.32786063938957;142.41022006177863;130.0184459215603;138.50178537839835;9.935760565288216;7.823663393651891;2.5838812214790905;4.845233234371805;2.8109105778891617;11.528103358190824;ruvB;Holliday junction ATP-dependent DNA helicase RuvB;COG2255;Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB;RuvB;HELO_RS08555;L;ruvB; Holliday junction ATP-dependent DNA helicase RuvB;3.6.4.12;ruvB;Holliday junction ATP-dependent DNA helicase RuvB;0.7107199491026561;-0.043824701235429586;-0.09051364486574265;1.1923733779692842;0.4816534288666281
HELO_2563;249.5554326973989;140.1642023439997;122.4976498757675;100.2058964359368;130.81327207078172;134.53722910383792;8.972933887418964;4.698300142721694;4.596246581416172;1.5786549984835145;2.118263414804252;0.9671819761173757;tolQ;ExbB family protein TolQ;COG0811;Biopolymer transport protein ExbB/TolQ;TolQ;HELO_RS08560;U;tolQ; ExbB family protein TolQ;;tolQ;ExbB family protein TolQ;0.8277555357774231;-0.13420559469010307;-0.04019354234445416;0.8864406368144362;0.05868510103701308
HELO_2564;178.92574013245363;107.41623731390253;67.16795349224428;64.6639157341492;80.68153511173458;74.09297524211217;12.926929540406839;5.763135375968266;4.65041094971223;2.549898976084493;4.496611821928199;6.072231846139206;tolR;ExbD family protein TolR;COG0848;Biopolymer transport protein ExbD;ExbD;HELO_RS08565;U;tolR; ExbD family protein TolR;;tolR;ExbD family protein TolR;0.7308207501189594;-0.13958428183073313;0.12133202670622545;1.2606517342616907;0.5298309841427313
HELO_2565;217.49105555748932;107.5221328415895;77.63152627500898;67.42377250676874;77.17751424101712;74.61204136422587;7.055048432025876;4.946140362013651;1.0153671716059987;4.0140363471437865;2.828523628052232;5.4419020968739655;tolA;TonB-like protein TolA;COG0810;Periplasmic protein TonB, links inner and outer membranes;TonB;HELO_RS08570;M;tolA; TonB-like protein TolA;;tolA;TonB-like protein TolA;1.0095849137954431;0.05649185332473827;0.0481377082058172;1.5308863109997821;0.521301397204339
HELO_2566;259.05587749822075;158.61015997900188;196.07479038346995;193.7793586402357;260.5167918420904;209.94418264246488;9.546977649159226;1.2668187109336115;8.496659014518348;4.140483711697666;20.201758410256254;17.2944666302922;tolB;translocation protein TolB;COG0823;Periplasmic component TolB of the Tol biopolymer transport system;TolB;HELO_RS08575;U;tolB; translocation protein TolB;;tolB;translocation protein TolB;0.7042691553320903;-0.09811806185005345;0.31004228218115504;0.3019603426362307;-0.4023088126958596
HELO_2567;2335.9354997370415;579.0793263775305;1411.3018912570997;1194.4224857892866;1768.3322373489857;1544.2974078129512;31.645878817722423;18.146226775955483;60.23737326186762;74.68942434599577;30.806795535292178;46.5700232926802;pal;peptidoglycan-associated lipoprotein;COG2885;Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins;OmpA;HELO_RS08580;M;pal; peptidoglycan-associated lipoprotein;;pal;peptidoglycan-associated lipoprotein;2.010295807058611;-0.1298360162029084;0.1953204505108559;0.5967333899444132;-1.413562417114198
HELO_2568;450.93799864550766;164.82078623416393;439.13227593261945;421.92777678614976;530.4751552402495;474.68057784276783;13.483882522925164;8.324125037553538;16.453823229228544;28.6987503818788;23.376767565944917;13.360302927537061;HELO_2568;YbgF family protein;COG1729;Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction;CpoB;HELO_RS08585;D;;pal;;HELO_2568;YbgF family protein;1.4464999977444872;-0.11205594907813676;0.16000913106162962;-0.07386825795725471;-1.520368255701742
HELO_2569;72.9977379185508;60.666306813090124;260.9575443615491;265.1738638158709;331.1463290181357;281.4916929986251;2.600877745531462;0.9631935994839851;8.024238673838381;13.634183055724385;17.037368878119864;3.9466737033604993;yciK;probable oxidoreductase YciK (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS08590;I;yciK; probable oxidoreductase YciK (short-chain dehydrogenase family);;yciK;probable oxidoreductase YciK (short-chain dehydrogenase family);0.26299872271233316;-0.10887543186668225;0.23361052539949867;-1.9326553700884457;-2.195654092800779
HELO_2570;200.84088541017164;147.48358700500822;171.25839707250273;190.86705627300117;204.63604801748303;171.45995777221037;6.909985932750529;15.741888881638875;5.480640023508794;8.753872666373294;2.137151184467951;3.745495286286672;HELO_2570;HAD superfamily hydrolase;COG0546;Phosphoglycolate phosphatase, HAD superfamily;Gph;HELO_RS08595;C;;yciK;3.1.3.105;HELO_2570;HAD superfamily hydrolase;0.44291497204512975;-0.0016871202299428845;0.2538317594049353;0.22695700820825326;-0.2159579638368765
HELO_2571;126.79906900310755;96.74508901721856;161.3679530095999;155.58386814020417;170.19083416478966;151.60544958925223;3.0197714210309075;7.395996682585186;6.57930807866004;4.92951565750316;4.61079129492558;4.8685198432360375;ubiG;bifunctional ubiquinone biosynthesis 0-methyltransferase UbiG;COG2227;2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase;UbiG;HELO_RS08600;H;ubiG; bifunctional ubiquinone biosynthesis 0-methyltransferase UbiG;2.1.1.222,2.1.1.64;ubiG;bifunctional ubiquinone biosynthesis 0-methyltransferase UbiG;0.3867812021312327;0.08946042990918279;0.16579897737983895;-0.25592915568418384;-0.6427103578154165
HELO_2572;619.342721777288;262.8790889924075;991.8968634295943;1174.6608471086793;791.3050581016372;889.3936211570491;31.903058458360146;8.765428098905119;29.30350032755709;6.056921608180249;120.15029980436644;141.27056053077666;galU;UTP--glucose-1-phosphate uridylyltransferase;COG1210;UTP-glucose-1-phosphate uridylyltransferase;GalU;HELO_RS08605;M;galU; UTP--glucose-1-phosphate uridylyltransferase;2.7.7.9;galU;UTP--glucose-1-phosphate uridylyltransferase;1.2331884545655623;0.15720060930068058;-0.16838724467915256;-0.5213777732601095;-1.7545662278256717
HELO_2573;604.1382291168485;215.52169304821052;561.2566151595214;580.8431373273445;438.42798460020964;542.9664955729546;14.699714063427775;10.673659442426127;17.838088502559028;14.393256261951478;77.36084510304713;91.34628595965118;ugd2;UDP-glucose 6-dehydrogenase;COG1004;UDP-glucose 6-dehydrogenase;Ugd;HELO_RS08610;M;ugd2; UDP-glucose 6-dehydrogenase;1.1.1.22;ugd2;UDP-glucose 6-dehydrogenase;1.4827531545646577;0.04771093538496274;-0.30789104506257914;0.15374693407507856;-1.3290062204895792
HELO_2574;105.17172573082401;88.39945352928284;78.24892100049293;71.67892075777296;82.975541952367;73.55258759708943;2.5857181672322223;2.06719041792812;5.891622741238074;5.6316690302198795;3.3061365650086048;9.735740716602004;sodB;superoxide dismutase (Fe);COG0605;Superoxide dismutase;SodA;HELO_RS08615;P;sodB; superoxide dismutase (Fe);1.15.1.1;sodB;superoxide dismutase (Fe);0.24806169975706016;0.08813286569152012;0.17171077426270198;0.5100692855139721;0.26200758575691196
HELO_2575;191.58186819152812;108.39432174763317;115.92333673722305;132.7145191492253;101.44498505832632;104.22301840690854;7.004612337746948;1.7814797896405608;9.437753708177814;19.655058809228755;8.22705735076438;7.736812414290106;HELO_2575;uncharacterized protein;COG1196;Chromosome segregation ATPase Smc;Smc;HELO_RS08620;D;;sodB;;HELO_2575;uncharacterized protein;0.8159340230070997;0.15211256557006614;-0.03860097814763819;0.8720215375008431;0.056087514493743384
HELO_2576;174.78525057563215;90.15087310046528;99.01033360734318;127.7165409873275;100.94585194696474;102.49049735254319;6.741910053202315;2.669798961200796;4.925173125644579;4.4748490347361995;6.5037095050544895;10.498613811455108;tamA;translocation/assembly module protein TamA;COG0729;Outer membrane translocation and assembly module TamA;TamA;HELO_RS08625;M;tamA; translocation/assembly module protein TamA;;tamA;translocation/assembly module protein TamA;0.9474856444100901;-0.04934922871805103;-0.021695228418685986;0.7643157214384972;-0.18316992297159285
HELO_2577;195.237329931452;108.77975628203683;172.7150255893673;186.8940845697098;166.33299983766793;157.87639353998082;4.352568866992034;2.38952743895568;5.183547281340698;5.112228512358084;13.183216265609987;11.391640771955927;tamB;translocation/assembly module protein TamB;COG2911;Autotransporter translocation and assembly protein TamB;TamB;HELO_RS08630;U;tamB; translocation/assembly module protein TamB;;tamB;translocation/assembly module protein TamB;0.8379874678116552;0.1288177667688073;0.07481720867498254;0.30469472988363044;-0.5332927379280248
HELO_2578;313.90315048907013;181.09237257904567;291.31503849231655;285.9466040951068;349.8494826303184;297.59610730644414;21.139118319655026;3.8724165830040076;21.73892502336286;2.4564271528370596;36.86375299301301;15.644607709248456;msrA1;peptide methionine sulfoxide reductase MsrA (S-form specific);COG0225;Peptide methionine sulfoxide reductase MsrA;MsrA;HELO_RS08635;O;msrA1; peptide methionine sulfoxide reductase MsrA (S-form specific);1.8.4.11;msrA1;peptide methionine sulfoxide reductase MsrA (S-form specific);0.7902376986932884;-0.030671305478660926;0.232656877304251;0.07671283349183255;-0.7135248652014559
HELO_2579;18.49625565249751;10.58292172513743;8.601874063416203;10.702630591537194;7.992408803828126;7.337411648111303;0.34555385193320637;1.166151433910429;0.11156012034562135;1.4631587034869882;0.368903886756906;0.44763661879014316;yheT;probable hydrolase YheT;COG0429;Predicted hydrolase of the alpha/beta-hydrolase fold;YheT;HELO_RS08640;R;yheT; probable hydrolase YheT;;yheT;probable hydrolase YheT;0.7511978634895886;0.2037164458918186;0.10910805531747281;1.2255256010240663;0.47432773753447766
HELO_2580;30.10868646473669;16.178211128572467;14.220169413802813;18.557117455819057;16.38784218693309;14.095870052565504;0.9136290597922504;2.07888507337977;0.3597892357500939;0.6464018889401015;0.17670647191890945;0.6009664563964243;HELO_2580;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS08645;K;;yheT;;HELO_2580;LysR family transcription regulator;0.8567376720021915;0.01183050821224585;0.20392499762725347;1.0431635705294715;0.18642589852727998
HELO_2581;18.56042907238078;20.0758520410214;27.26914747650545;24.641704350932716;37.55079009030505;32.42266823580044;0.6894797998134892;1.4121053960796284;1.9659572101526321;3.524834458993982;2.5112261064799455;3.585980723368652;HELO_2581;ABC-type transport system ATP-binding protein;COG0444;ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component;DppD;HELO_RS08650;EP;;;;HELO_2581;ABC-type transport system ATP-binding protein;-0.10765293948286558;-0.24159853692056554;0.2059335153341788;-0.7728888956266733;-0.6652359561438077
HELO_2582;15.770462779535817;17.351259369817473;23.53947296155339;21.625866674305502;33.4485155665038;28.030432554427488;1.249147124001427;1.4183965310067952;0.551368841102099;2.7443760508979316;2.864111634585969;1.9964614041236963;HELO_2582;ABC-type transport system ATP-binding protein;COG0444;ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component;DppD;HELO_RS08655;EP;;;;HELO_2582;ABC-type transport system ATP-binding protein;-0.12995657206209188;-0.24246180400358686;0.24687574824331548;-0.7916435678275509;-0.661686995765459
HELO_2583;7.5604911794215575;12.463138202654818;18.024555075210063;17.64202813056444;20.104726628849793;18.222458381202085;0.9900555733724448;0.7645941424992128;0.9549490585643733;2.1291870366245274;0.2702079869113142;2.556794543214586;HELO_2583;ABC-type transport system permease protein;COG1173;ABC-type dipeptide/oligopeptide/nickel transport system, permease component;DppC;HELO_RS08660;EP;;;;HELO_2583;ABC-type transport system permease protein;-0.6532492531615657;-0.014930141753517923;0.13477328632061525;-1.1670273734344727;-0.513778120272907
HELO_2584;9.430746546422151;14.502805475751478;22.323980591703375;29.63398917881388;24.482329341505714;24.07946506553301;0.6433042519581638;0.3186440469562413;2.601811195156856;3.440633207176603;0.6442095745161276;1.877466428065673;HELO_2584;ABC-type transport system permease protein;COG0601;ABC-type dipeptide/oligopeptide/nickel transport system, permease component;DppB;HELO_RS08665;EP;;;;HELO_2584;ABC-type transport system permease protein;-0.5716868997044338;-0.10469254900607883;0.02299058408828447;-1.2656641586765387;-0.6939772589721049
HELO_2585;74.37200259326421;76.04357089562403;175.24072578643964;269.4814887613193;228.528531389337;181.53272957358521;7.114651875543527;5.066070509284663;6.817627705594614;15.681365787162505;8.724592038821157;28.663209562779112;HELO_2585;ABC-type transport system periplasmic substrate-binding protein;COG0747;ABC-type transport system, periplasmic component;DdpA;HELO_RS08670;E;;;;HELO_2585;ABC-type transport system periplasmic substrate-binding protein;-0.03164584745309984;-0.05060783250595424;0.3305183241103986;-1.276054543987751;-1.2444086965346512
HELO_2586;652.2270797102155;357.32548671078877;449.34359020804715;291.7875117141136;471.70562462289536;518.2592047133331;17.22114980210588;10.221324045049355;6.510099420724217;14.770266575636148;55.38486700484006;94.69953861273424;can;carbonic anhydrase;COG0288;Carbonic anhydrase;CynT;HELO_RS08675;P;can; carbonic anhydrase;4.2.1.1;can;carbonic anhydrase;0.8663139373169617;-0.20542875786810555;-0.13551285429322846;0.33112971405241254;-0.5351842232645492
HELO_2587;175.3679918158609;157.06490753404486;138.3521237211518;118.07238325574043;174.38493237076145;151.2585735267636;2.3671269677486846;4.178683542030096;11.029472841218821;4.603611630592455;7.427122465700455;10.111167850257333;gor;glutathione reductase;COG1249;Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase;Lpd;HELO_RS08680;C;gor; glutathione reductase;1.8.1.7;gor;glutathione reductase;0.1580716506447919;-0.12778847789434788;0.20400134150592475;0.2120652896997468;0.05399363905495491
HELO_2588;60.192447256579364;407.21823231454863;292.3633823027282;324.9447546600359;460.27866072938576;280.7144186862902;0.7215914403932858;49.72344155085408;9.98730467433933;25.899706186636976;69.79218478907185;18.792359116136826;ectA;L-2%2C4-diaminobutyrate acetyltransferase;COG1247;L-amino acid N-acyltransferase MnaT;MnaT;HELO_RS08685;E;ectA; L-2,4-diaminobutyrate acetyltransferase;2.3.1.178;ectA;L-2%2C4-diaminobutyrate acetyltransferase;-2.737915116286925;0.05845539914900044;0.7114051477369152;-2.202807902675926;0.5351072136109991
HELO_2589;105.22094081383624;1174.8285985064056;698.8566090599155;635.9596266837633;1086.0891510713911;759.0438760890361;1.7566898770580008;30.11136867820023;46.9439239992037;74.18352899049745;73.69379703903726;35.72769566360483;ectB;diaminobutyrate--2-oxoglutarate aminotransferase;COG0160;Acetylornithine aminotransferase/4-aminobutyrate aminotransferase;ArgD;HELO_RS08690;E;ectB; diaminobutyrate--2-oxoglutarate aminotransferase;2.6.1.76;ectB;diaminobutyrate--2-oxoglutarate aminotransferase;-3.468537654802475;-0.11902334131053571;0.5163156486678364;-2.839014492630591;0.6295231621718838
HELO_2590;504.77471687475855;2768.351023230259;1062.4504077229365;813.2276778952197;1285.0338055567147;1097.185974158973;18.018718649573994;122.20430832799005;67.48677495247715;56.4882603392961;94.31997987520506;99.03287473225518;ectC;L-ectoine synthase;COG1917;Cupin domain protein related to quercetin dioxygenase;QdoI;HELO_RS08695;R;ectC; L-ectoine synthase;4.2.1.108;ectC;L-ectoine synthase;-2.452981105884831;-0.04636963352671941;0.2278061761631669;-1.1185555654931374;1.3344255403916936
HELO_2591;147.64458772645062;72.97451730308221;76.12117535451961;91.10538707302065;74.80672362212725;76.95982877333854;4.904795034515976;2.510841209253809;0.6970367915673589;4.596311867740626;2.540461561615498;2.432977040167355;HELO_2591;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS08700;K;;ectC;;HELO_2591;AraC family transcription regulator;1.0067666517507279;-0.01560388301555804;-0.04040510908661776;0.9310641074146213;-0.07570254433610657
HELO_2592;282.79583709373213;131.65841346235172;96.65052730646846;107.4427574068605;79.89822220603766;94.69122401963477;13.052957630151818;4.6326007497669695;11.834208520506609;8.394004553534858;10.283441486962067;7.205469807527309;HELO_2592;DUF218 domain protein;COG1434;Lipid carrier protein ElyC involved in cell wall biogenesis, DUF218 family;ElyC;HELO_RS08705;M;;;;HELO_2592;DUF218 domain protein;1.0971372500643248;0.029241215459840042;-0.2422786203424332;1.568394902897504;0.4712576528331791
HELO_2593;125.7544201838759;40.066102691250414;50.0914428324187;66.74423481245516;59.893460874371364;53.01479356144114;1.9751258709005046;1.8645842181226686;2.7048326178130027;1.1491917309728499;2.66737327650776;2.208335141798782;HELO_2593;DUF1006 domain protein;COG3214;DNA glycosylase YcaQ, repair of DNA interstrand crosslinks;YcaQ;HELO_RS08710;L;;;;HELO_2593;DUF1006 domain protein;1.626016115407003;-0.08027290813391996;0.17293272427633966;1.2306095662579608;-0.39540654914904216
HELO_2594;906.9477867847169;224.46404430860426;364.914973002187;481.3229436523643;178.60475228405562;292.5529171137327;50.284811017379596;19.263741919177317;43.97910490665194;158.8683846946923;12.613120054350647;36.68262234716001;HELO_2594;YqjC family protein;;;;;;;;;HELO_2594;YqjC family protein;2.0097119558279273;0.3178878578225479;-0.7087950693715328;1.628988741854318;-0.3807232139736092
HELO_2595;13.527838178371368;24.874729660863224;10.289226242019884;6.852866072891062;5.829407083907237;9.53705542910051;1.0948910458022152;1.4806138887513256;1.4705756105692784;1.0795844026514847;0.4235576251196456;0.7721055648865761;HELO_2595;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS08720;G;;;;HELO_2595;major facilitator superfamily transport protein;-0.8327237513708408;0.09947484446330268;-0.6256395263980044;0.46334827461231143;1.2960720259831522
HELO_2596;217.2858705127336;98.322200890834;157.35079667671494;179.108141017658;139.5416336446284;148.0596568532526;2.1171573375923964;2.783621589833331;3.634316472030337;8.139619827906575;10.932240918308773;10.517362728550843;HELO_2596;peptidase domain protein;COG4067;Uncharacterized conserved protein;;HELO_RS08725;S;;;;HELO_2596;peptidase domain protein;1.1360306129305107;0.08723428212802364;-0.08489227003853639;0.5503289051581168;-0.5857017077723938
HELO_2597;133.2342789266731;61.66393196764094;100.56093755036311;110.74272331457752;88.74731509006055;98.42429467834613;4.3447155200563845;2.5246442273076095;3.797241014688664;3.688128754834021;4.326549929003199;6.709019911524017;HELO_2597;uncharacterized protein;;;;;;;;;HELO_2597;uncharacterized protein;1.099045932141034;0.030675290646828834;-0.14772964305929825;0.4330828068301722;-0.6659631253108618
HELO_2598;177.20159321044298;69.62903487901845;123.83862976154359;152.64594890661155;146.10943045086722;119.4458658647382;1.1995922862135653;1.9494416910487586;9.861730825925203;11.20756955002779;16.80897511322699;10.915968361412897;HELO_2598;glutamate ligase domain protein;COG0189;Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily;LysX;HELO_RS08735;JEHQ;;;;HELO_2598;glutamate ligase domain protein;1.335176947497576;0.05167955138011138;0.28850485758673816;0.5651253593810193;-0.7700515881165568
HELO_2599;161.18379416120067;124.61908338899183;125.76097829138183;176.2047947396867;157.22368509742702;123.69985071616406;3.7654473136332323;1.694410455018223;9.908777087328994;6.1404122817665;13.053469961761568;7.161520846302839;hisI;phosphoribosyl-AMP cyclohydrolase;COG0139;Phosphoribosyl-AMP cyclohydrolase;HisI1;HELO_RS08745;E;hisI; phosphoribosyl-AMP cyclohydrolase;3.5.4.19;hisI;phosphoribosyl-AMP cyclohydrolase;0.3685740213026554;0.02365096097565811;0.34350584036020315;0.37916993075407657;0.010595909451421193
HELO_2600;135.44072436608909;102.56312867934498;40.47257001528436;55.150920292225294;53.091769249386545;38.95459025622076;3.0661162186533466;4.445418279513965;3.1260576640942532;3.7469617600659135;3.372920193658671;0.7037257499660681;yidD;probable membrane protein insertion efficiency factor;COG0759;Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ;YidD;HELO_RS08750;M;yidD; probable membrane protein insertion efficiency factor;;yidD;probable membrane protein insertion efficiency factor;0.3977638640315915;0.05379619310346495;0.43704782701887446;1.771841154928743;1.3740772908971515
HELO_2601;112.94751011372911;122.83871726572703;183.74905681438506;187.68071207962814;253.87730929543662;184.70552344337761;5.1720745415933616;9.438502683646622;24.54202417112137;1.0828259376708795;6.674008895411588;10.04516933940533;sufE;sulfur acceptor protein SufE;COG2166;Sulfur transfer protein SufE, Fe-S cluster assembly;SufE;HELO_RS08755;O;sufE; sulfur acceptor protein SufE;;sufE;sulfur acceptor protein SufE;-0.120093032712691;-0.007449726914545707;0.45678621570278555;-0.7046473256462606;-0.5845542929335696
HELO_2602;26.484808257817306;34.95117719300375;44.351228907015106;40.63488684795195;48.81184502756173;43.123594366456985;1.802951636538467;1.6026329076691266;4.568702251525268;1.7768751544937238;4.706995809734814;3.120455566301686;HELO_2602;integrase family protein;COG4974;Site-specific recombinase XerD;XerD;HELO_RS08760;L;;sufE;;HELO_2602;integrase family protein;-0.3874045966098878;0.03959132521297182;0.17493852976659596;-0.682915904824017;-0.2955113082141292
HELO_2603;33.99392102429402;42.32988350498627;46.68555497250322;53.389789131833936;47.53127430059377;41.189143761151904;1.5425857936106653;1.8660254565829206;4.789446199179632;6.772045519092733;6.540947160594862;0.5039721466837301;HELO_2603;uncharacterized protein;;;;;;;;;HELO_2603;uncharacterized protein;-0.30825803206479296;0.17668049961154075;0.20204293387623284;-0.26976748223327984;0.03849054983151312
HELO_2604;297.9433711399967;296.8795021910194;260.25557774079624;199.0432632775595;248.20480234526977;248.18322868127552;6.510984788492124;10.775090655397172;15.253834850748152;12.381431173327409;10.259300405000749;32.565865772890106;nfuA;Fe/S biogenesis protein NfuA;COG0694;Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain;NifU;HELO_RS08770;O;nfuA; Fe/S biogenesis protein NfuA;;nfuA;Fe/S biogenesis protein NfuA;0.005143368832133177;0.06825486789879509;0.00012489954067973486;0.2626652497007642;0.25752188086863104
HELO_2605;124.60685979569844;125.41747284152511;168.62684324400482;180.4591000796939;189.8177426178266;174.08181059605738;0.6659184353999209;3.0339997608574185;10.35303424642285;3.4106922500030428;10.364105048505982;10.74087790207232;metH;methionine synthase%2C cobalamin-dependent;COG1410;Methionine synthase I, cobalamin-binding domain;MetH2;HELO_RS08775;E;metH; methionine synthase, cobalamin-dependent;2.1.1.13;metH;methionine synthase%2C cobalamin-dependent;-0.009280623358101536;-0.045664715971418524;0.12416611357477958;-0.4791139520845942;-0.46983332872649264
HELO_2606;45.53676222980681;64.83284383890317;38.05915428672335;46.17883428249709;37.606133150046404;38.76574820658625;1.7664365794710601;1.1783773036214036;1.330757321828268;3.3553756549608713;0.6440215423709701;2.855023449777668;HELO_2606;MATE family transport protein;COG0534;Na+-driven multidrug efflux pump, DinF/NorM/MATE family;NorM;HELO_RS08780;V;;metH;;HELO_2606;MATE family transport protein;-0.5004366809577023;-0.025865603833216788;-0.04269625704661273;0.22684452350558892;0.7272812044632913
HELO_2607;456.7869192559828;783.9626834314917;563.3850534583854;447.1643341848731;471.2153237411579;564.8346976271063;50.448779710476884;12.370673614284291;97.81987595033655;34.15408789476838;24.575455642081444;53.50379707832084;HELO_2607;ferredoxin domain protein / 4Fe-4S domain protein;COG0155;Sulfite reductase, beta subunit (hemoprotein);CysI;HELO_RS08785;P;;;1.8.1.2;HELO_2607;ferredoxin domain protein / 4Fe-4S domain protein;-0.7779478308350853;-0.0037008654257260076;-0.2609357882857424;-0.30570440704555146;0.4722434237895339
HELO_2608;970.8257678114032;1566.444050251105;484.4767841866031;416.6414778399189;358.36450379912367;527.1529134167503;113.38320454558671;173.9594133493393;26.769697651960257;29.3712567829039;30.14500338006302;47.15452139694534;HELO_2608;DUF934 family protein;COG3749;Uncharacterized conserved protein, DUF934 family;;HELO_RS08790;S;;;;HELO_2608;DUF934 family protein;-0.6896443561870775;-0.12155337950692058;-0.555507772397311;0.8797419996081999;1.5693863557952774
HELO_2609;36.2885841558326;14.827447624024636;38.34208814389635;58.00098471286168;60.30290479523472;35.330642951091285;3.9505369326211865;0.6428974760090127;5.100943793473849;6.084597448138922;4.551853687708122;1.501907717287889;smrA;probable DNA endonuclease SmrA;COG2840;DNA-nicking endonuclease, Smr domain;SmrA;HELO_RS08795;L;smrA; probable DNA endonuclease SmrA;;smrA;probable DNA endonuclease SmrA;1.2363053977289509;0.11488663532299626;0.7547685389710814;0.037547121491957824;-1.198758276236993
HELO_2610;28.32417735768625;20.91912488954085;28.611153721438523;32.7666385182592;35.92870949963045;27.86729728526048;3.2942562001384643;2.381264062680334;2.4461310329005244;3.0289138494986654;3.175049675337738;4.361888142109208;HELO_2610;BtrG domain protein;;;;;;;;;HELO_2610;BtrG domain protein;0.4199004358015994;0.03670466159097341;0.3553068065342;0.022654595475920303;-0.3972458403256791
HELO_2611;12.776598056335892;5.093067938435914;6.355257695621117;8.00504220515947;9.200651897435815;7.042149992007814;1.5127783172044036;1.2386492173673074;1.3058897740961488;0.8165765280740581;2.00721550114147;0.770103814592296;HELO_2611;YhiD family protein;COG1285;Magnesium uptake protein YhiD/SapB, involved in acid resistance;SapB;HELO_RS08810;P;;;;HELO_2611;YhiD family protein;1.1769789463073628;-0.12880535570818452;0.34300820524910103;0.7765665292624431;-0.4004124170449197
HELO_2612;65.5673468750707;45.81853534822034;84.23132896240064;88.46420349889269;80.33499906593492;88.29137998817271;3.373050674123208;10.959081098746216;10.376813510231404;10.276273191868688;5.566781849264599;4.580303992366908;HELO_2612;ArsC family protein;COG1393;Arsenate reductase or related protein, glutaredoxin family;ArsC;HELO_RS08815;P;;;1.20.4.1;HELO_2612;ArsC family protein;0.5077348665069907;-0.06713707963910398;-0.13464461865912103;-0.4237062381800918;-0.9314411046870825
HELO_2613;105.4390302652992;81.27445918840193;107.30268628707978;128.60302474082187;119.18416779945682;117.80829803463858;9.821614111562551;5.49979204831306;2.6426087713642366;10.275929837062057;4.869515051403624;4.0401726067796515;wrbA;NAD(P)H dehydrogenase (quinone);COG0655;Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase;WrbA;HELO_RS08820;C;wrbA; NAD(P)H dehydrogenase (quinone);1.6.5.2;wrbA;NAD(P)H dehydrogenase (quinone);0.3715107282818719;-0.13356657580771447;0.016611255162547245;-0.1586083315404201;-0.530119059822292
HELO_2614;139.35101630543878;93.2831618579521;122.03851944949587;138.4468802715834;138.8259417572901;134.40945755287927;4.970560672017521;1.1760322679181745;5.917482788664934;5.408474639609496;15.302135082240445;3.2315767485354736;HELO_2614;DUF2069 domain protein;COG3308;Uncharacterized membrane protein;;HELO_RS08825;S;;wrbA;;HELO_2614;DUF2069 domain protein;0.573967464293232;-0.13821845794219279;0.04630354103115675;0.05171100450569277;-0.5222564597875392
HELO_2615;211.95460610684586;152.2363761140888;240.8077601516023;209.1641570790864;299.0544667462982;235.6902019354111;13.728365355541046;7.321279641923752;11.586869766528693;11.481923876424133;9.347273469579628;16.73667392198944;pdxH;pyridoxine/pyridoxamine 5'-phosphate oxidase;COG0259;Pyridoxine/pyridoxamine 5'-phosphate oxidase;PdxH;HELO_RS08830;H;pdxH; pyridoxine/pyridoxamine 5'-phosphate oxidase;1.4.3.5;pdxH;pyridoxine/pyridoxamine 5'-phosphate oxidase;0.47478712203965845;0.03086055935983989;0.3422244213499468;-0.1524540502459537;-0.6272411722856122
HELO_2616;47.62073202984445;15.522332441246661;33.446955385071305;52.904459645484515;44.9807131247235;32.037119693636264;1.0247880954240378;0.41709244891632147;1.2708574681393365;1.8887116673261932;4.31253486978782;2.7847891661408855;pka2;protein lysine acetyltransferase Pka;COG1247;L-amino acid N-acyltransferase MnaT;MnaT;HELO_RS08835;E;pka2; protein lysine acetyltransferase Pka;;pka2;protein lysine acetyltransferase Pka;1.557154249672033;0.060288562695380854;0.4769409288981814;0.5574837022333936;-0.9996705474386394
HELO_2617;58.161350908670705;17.031693077110308;85.24889726861042;79.50944358335833;168.9649301242623;84.74329121650946;8.971619237308357;1.5623166476711594;14.967528693082858;5.054925347235147;7.206305422112595;0.7653348187174462;HELO_2617;histone deacetylase superfamily protein;COG0123;Acetoin utilization deacetylase AcuC or a related deacetylase;AcuC;HELO_RS08840;Q;;pka2;;HELO_2617;histone deacetylase superfamily protein;1.714120131475898;0.008482215985162078;0.987141396703322;-0.5353687996385128;-2.249488931114411
HELO_2618;43.28228008424989;30.17421016255881;52.292168691319546;48.17612084741719;55.87483262470886;43.51451249228533;1.2569700885822637;0.7365855888768741;2.2567194432573743;3.9906109199965303;9.87603354862123;4.648163487929026;HELO_2618;PuuR family transcription regulator;COG1396;Transcriptional regulator, contains XRE-family HTH domain;HipB;HELO_RS08845;K;;;;HELO_2618;PuuR family transcription regulator;0.5063765000200817;0.2596477878411818;0.35351463852009246;-0.007546247957197494;-0.5139227479772792
HELO_2619;107.9474412290768;67.88375700647448;65.1799743947454;58.7812231909179;78.1253344363675;62.929897186903986;1.4970538962407496;7.941939515938441;9.345656177694154;4.478175953877147;6.7681338556255035;6.436221597207495;HELO_2619;DUF1244 domain protein;COG3492;Uncharacterized conserved protein, DUF1244 family;;HELO_RS08850;S;;;;HELO_2619;DUF1244 domain protein;0.6613965769115593;0.04990395978888884;0.307648918665957;0.7690696345105126;0.10767305759895329
HELO_2620;141.28812795842566;113.75825596399623;105.12366280186181;95.26724182293658;130.21735884174123;109.54163249099194;8.41058007270919;5.947814850789592;5.164941552953622;8.15927642349444;14.037186052117868;0.14277808667279746;moaB;molybdenum cofactor biosynthesis protein MoaB;COG0521;Molybdopterin adenylyltransferase MoaB/MogA;MoaB;HELO_RS08855;H;moaB; molybdenum cofactor biosynthesis protein MoaB;2.7.7.75;moaB;molybdenum cofactor biosynthesis protein MoaB;0.3102173452162189;-0.05884344830942112;0.24736876407733543;0.3642254695755831;0.054008124359364196
HELO_2621;132.66733037748762;99.08103870931052;183.03122464156124;185.3336051549867;233.77269644114588;187.92933278485506;5.5371584159137015;1.8094576514659508;1.7684247085967908;8.20335302789828;1.4015751670472212;1.3300836428684732;moeA;molybdopterin molybdenumtransferase;COG0303;Molybdopterin Mo-transferase (molybdopterin biosynthesis);MoeA;HELO_RS08860;H;moeA; molybdopterin molybdenumtransferase;2.10.1.1;moeA;molybdopterin molybdenumtransferase;0.4174782315569834;-0.03789613940331282;0.3134179268572428;-0.49919980949627263;-0.916678041053256
HELO_2622;139.65686756765214;113.87898004867662;69.61965155590157;80.54416470942776;87.20891237048602;63.86747715378811;7.005045910356563;10.38148137119877;7.4321766033172345;1.6049159456447688;2.4578815013043616;3.821571418109421;acpH;(acyl-carrier-protein) phosphodiesterase;COG3124;Acyl carrier protein phosphodiesterase;AcpH;HELO_RS08865;I;acpH; (acyl-carrier-protein) phosphodiesterase;3.1.4.14;acpH;(acyl-carrier-protein) phosphodiesterase;0.29206514853366805;0.12257437255954429;0.4434290986735112;1.116612758644381;0.824547610110713
HELO_2623;142.10601047903032;102.52131159984441;45.47328117347621;47.521660785345574;59.372851285106044;49.90567339537075;3.8802754665826;3.575011500152839;0.9543233002350132;3.344418519471125;5.258640910400844;10.22758676399919;tusE;sulfurtransferase TusE;COG2920;Sulfur transfer complex TusBCD TusE component, DsrC family (tRNA 2-thiouridine synthesizing protein C);TusE;HELO_RS08870;J;tusE; sulfurtransferase TusE;2.8.1.-;tusE;sulfurtransferase TusE;0.46715646550330625;-0.13142494475940225;0.24607348583204125;1.4911859092487818;1.0240294437454756
HELO_2624;175.03703322669796;184.27944242890453;48.12070617446678;49.8861569896227;50.84002167357574;49.960971375749644;2.98430184741722;7.663672695474612;2.2650850254947454;4.3378604876238755;15.667088842953904;7.775379990633114;tusB;sulfur relay complex subunit TusB;COG2168;Sulfur transfer complex TusBCD TusB component, DsrH family;TusB;HELO_RS08875;J;tusB; sulfur relay complex subunit TusB;;tusB;sulfur relay complex subunit TusB;-0.07382385373197664;-0.05306147582467702;0.024673544080897614;1.7884142807121846;1.8622381344441612
HELO_2625;222.45114963270547;173.1100679540357;68.15568461223157;66.37082949662941;77.68504096446887;72.10294142893518;4.504099455957683;5.308745957756412;4.637874024353123;4.98426129576207;9.893890410867503;10.003038810541385;tusC;sulfur relay complex subunit TusC;COG2923;Sulfur transfer complex TusBCD TusC component, DsrF family;DsrF;HELO_RS08880;J;tusC; sulfur relay complex subunit TusC;;tusC;sulfur relay complex subunit TusC;0.3599598376985709;-0.08008161069285702;0.10615993018189496;1.6119581053665764;1.2519982676680055
HELO_2626;192.83891386647701;176.11441212000182;105.5626632153917;117.2235694242806;113.97676721178881;122.31933123646884;12.005110691944207;6.415031816532608;14.98965928105671;11.898104780087236;7.31677239487305;6.517350440193268;tusD;sulfurtransferase TusD;COG1553;Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family;DsrE;HELO_RS08885;P;tusD; sulfurtransferase TusD;2.8.1.-;tusD;sulfurtransferase TusD;0.13017661453086937;-0.21069692698639386;-0.101056598463102;0.6524592552906618;0.5222826407597925
HELO_2627;1306.0068690387695;759.4550776775385;1149.0176783566515;1128.6897520301316;1423.8481812421462;1248.035424809683;81.17518969292088;25.61674912533823;112.3264479465423;17.2366567526685;54.32042908927749;87.28022298189772;yccA;modulator of FtsH protease YccA;COG0670;Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family;YbhL;HELO_RS08890;P;yccA; modulator of FtsH protease YccA;;yccA;modulator of FtsH protease YccA;0.7813317919759708;-0.11915835605251779;0.18999381225252954;0.06545232844968574;-0.7158794635262851
HELO_2628;189.15560504267486;88.62456146750799;674.7261920936384;984.3360285236434;469.5757419574654;525.9302467860794;8.515539959142279;3.4024300230253797;89.70379983389816;24.866153771865843;195.82551849916356;282.8572935849959;HELO_2628;hydrolase domain protein;COG3049;Penicillin V acylase or related amidase, Ntn superfamily;YxeI;HELO_RS08900;MR;;;;HELO_2628;hydrolase domain protein;1.085214404750669;0.3588267815900661;-0.1631850435243809;-1.470431530897832;-2.555645935648501
HELO_2629;14.936302585740185;13.032789826550081;10.43332961672148;19.81008596888164;11.450998764588277;8.80909358142977;0.19498800649966117;0.3557249133443699;1.364904256389529;1.7229203654386493;0.8974039819056595;0.6347619743741174;HELO_2629;GNAT family acetyltransferase;;;;;;;;;HELO_2629;GNAT family acetyltransferase;0.1835150891727313;0.22105387258628628;0.3440697394961991;0.700125211399329;0.5166101222265977
HELO_2630;1.9261310311767523;8.025506569845252;1.7709144169529365;9.0634579369908;1.0905386198526896;1.3705582086747927;0.30180885322531636;0.29551580779766223;0.7637356332072259;2.472326975674302;0.07144328708947635;0.36445648367518707;HELO_2630;uncharacterized protein;;;;;;;;;HELO_2630;uncharacterized protein;-1.6250135333274607;0.22513533348067583;-0.18135212319000793;0.30376755568470015;1.9287810890121608
HELO_2631;2.232720223641495;9.15035720886507;1.3658090675512493;12.24176741856474;1.2066695026238674;1.5507621292829459;0.21472829058981413;0.4743208568108826;0.2574215422222695;3.0284349166621465;0.2991430965561286;0.24764357597140815;HELO_2631;uncharacterized protein;;;;;;;;;HELO_2631;uncharacterized protein;-1.6507099395964533;-0.10859472125204972;-0.20905779660088109;0.3418202875329801;1.9925302271294334
HELO_2632;2.3031589399150327;11.491155323074802;2.383061398997663;12.007483332575125;2.043971741562611;2.217707043825125;0.3396323688368766;0.8169860679376864;0.10279814075548147;4.3341311958171;0.47088896821357057;0.26848518644256675;HELO_2632;uncharacterized protein;;;;;;;;;HELO_2632;uncharacterized protein;-1.918988624486301;0.07229637890970975;-0.08007801607956222;0.03781340839044178;1.9568020328767428
HELO_2633;7.372085582652493;6.447112630173706;3.325172094189456;5.444684265604547;3.5322561641656343;2.568158297440122;0.10622394049227939;0.1299069454837233;0.3767505777268345;0.7872399152145898;0.3686310102898113;0.16627637697934386;HELO_2633;uncharacterized protein;;;;;;;;;HELO_2633;uncharacterized protein;0.1689058824048515;0.2775779169912034;0.3450497846544538;1.2304074391825517;1.0615015567777002
HELO_2634;12.099774596556683;8.137868673871012;3.4206565071597406;5.631550699841235;4.646373395014184;3.031599662163757;0.13188456465493198;0.4268301061888707;0.5493974935661372;0.23793171739174176;0.12592773760634798;0.4987400116590205;HELO_2634;uncharacterized protein;;;;;;;;;HELO_2634;uncharacterized protein;0.519612374085936;0.13290825235073633;0.4859721511163677;1.7001176965559672;1.1805053224700313
HELO_2635;17.544705775337373;9.460752948965856;2.576147559322211;4.162855188924147;2.9841764682371927;2.5599228354515;1.0464990560744147;0.7835779502640767;0.6432405051431545;1.4745869148664983;0.6453268026516898;0.5642027193685794;HELO_2635;DUF4376 domain protein;;;;;;;;;HELO_2635;DUF4376 domain protein;0.826020680361351;0.006560296551708644;0.16243557925551633;2.3810895037388287;1.5550688233774776
HELO_2636;2.3534753555037757;10.275701406114116;1.3236547544737889;1.530369806152908;1.201204381378224;1.1819146364409796;0.18091618444100327;1.0200188315465928;0.658077269243605;0.17235236287369454;0.1898914195647984;0.26725955153251885;HELO_2636;WD40 domain protein;COG3391;DNA-binding beta-propeller fold protein YncE;YncE;HELO_RS09000;R;;;;HELO_2636;WD40 domain protein;-1.7494882743368616;0.09080107109033553;0.0126984455206689;0.6200623399407901;2.3695506142776517
HELO_2637;0.4711597455943184;19.31272508044586;0.0;0.16576751953781813;0.0;0.0;0.19609377061086583;6.732719767271059;0.0;0.28711776608416756;0.0;0.0;HELO_2637;uncharacterized protein;;;;;;;;;HELO_2637;uncharacterized protein;-3.7873579843044776;0.0;0.0;0.5569539098584264;4.344311894162904
HELO_2638;1.9933831937841238;10.940694160080929;1.4895750865429853;2.371372388162875;2.2749077840087497;1.5036299978861092;0.16335048630151486;1.1691913663668616;0.13338871152776952;0.11904697896615424;0.1267948538935973;0.5701767259631084;HELO_2638;uncharacterized protein;;;;;;;;;HELO_2638;uncharacterized protein;-1.9960378282771447;-0.008121839221356453;0.38743291579449046;0.2577556077368661;2.2537934360140106
HELO_2639;0.6588299154425462;32.69711356797104;0.3099778651183656;0.15695009828580656;0.25728385875814147;0.8070306531163403;0.36491525128784086;5.473916454746169;0.11377353421050207;0.27184554448394593;0.31209110939147566;0.4589627701643592;HELO_2639;homolog to phage protein MTPG_00003;;;;;;;;;HELO_2639;homolog to phage protein MTPG_00003;-4.344387142771181;-0.46407854466350573;-0.5233105733731853;-0.12345500896581729;4.220932133805364
HELO_2640;1.575322630426702;17.73275958722965;0.43071555967202246;0.5919338325226665;0.35242639746855425;0.5805386095497718;0.22043909644088344;1.0168274747546768;0.257546769330583;0.406295761554491;0.10239735739394526;0.11714010173350453;HELO_2640;uncharacterized protein;;;;;;;;;HELO_2640;uncharacterized protein;-2.8627383573956076;-0.14367939936101126;-0.22486619696187943;0.7043369031291116;3.567075260524719
HELO_2641;1.6707909577718496;29.98406406171992;0.8215084714572639;1.5942621894660665;1.3775468364137258;1.511530150938876;0.8658643261056937;1.8314303678548598;0.11109575388603077;0.3742808306611952;0.33763764868837837;0.1989204479208008;HELO_2641;homolog to phage protein PEp14_00013;;;;;;;;;HELO_2641;homolog to phage protein PEp14_00013;-3.536187423277868;-0.46343288990778175;-0.07909283298467296;0.08870046628557304;3.624887889563441
HELO_2642;1.2239495860961982;41.352989594615366;0.7830240925205079;1.1218308070866865;0.7176211996416142;0.7699909933887343;0.30736117846226546;4.459127826243329;0.7484305165642062;0.579209006003931;0.3579299819916858;0.4926548293434504;HELO_2642;uncharacterized protein;;;;;;;;;HELO_2642;uncharacterized protein;-4.25126781987305;0.010584177868533273;-0.04333011636297124;0.32938206533987624;4.580649885212926
HELO_2644;0.29169110675655435;63.462852194191775;0.7745613208116224;0.3661919010853514;0.1557368983647943;1.256471819956511;0.015569207167229896;6.8410126178249095;0.18185571261579414;0.08511916754951677;0.09777309537000436;0.3307148272383214;HELO_2644;uncharacterized protein;;;;;;;;;HELO_2644;uncharacterized protein;-5.641135010369468;-0.3466063332305559;-0.965255753481283;-0.8048076543454598;4.836327356024008
HELO_2645;0.8621465151822042;7.49345179061524;0.5938503531869382;0.4326298014750331;0.5655280481541775;0.5567514127817625;0.2129839493072238;0.5290571636399174;0.20343472293986298;0.1537054517005785;0.08244688323847435;0.031678939081917115;HELO_2645;uncharacterized protein;;;;;;;;;HELO_2645;uncharacterized protein;-2.1893844032511;0.03397759237622455;0.008110767684893938;0.2584280012769604;2.4478124045280607
HELO_2646;4.357848233805959;8.300439632400758;1.463907034126749;2.2981172940670067;1.851233814575739;1.6900003325357031;0.43046659908392;0.1584904573632456;0.1801968916503484;0.18306254049268342;0.3709670559850644;0.26515947126631584;HELO_2646;uncharacterized protein;;;;;;;;;HELO_2646;uncharacterized protein;-0.7956451980859622;-0.12665852850890724;0.08398000077540768;0.994047364910509;1.7896925629964713
HELO_2647;1.3540143192460923;7.071567467237976;0.39146685965390243;0.8816712679287199;0.5178660655344265;0.5393634162729909;0.08221484169361488;0.3643604170042735;0.251014513036991;0.35812179752526957;0.15372702852682918;0.11489767682338556;HELO_2647;uncharacterized protein;;;;;;;;;HELO_2647;uncharacterized protein;-1.7777257703365552;-0.14572731782957982;-0.02028937157437305;0.6127892297116204;2.3905150000481754
HELO_2648;2.1793470317512837;13.3424223560082;0.6855688196970616;1.2483908017725074;0.7592524344329198;0.5032696350128956;0.24218341696199513;1.2094366799318008;0.2380799158698367;0.17202722064660472;0.17258092696069346;0.2505206279440578;HELO_2648;uncharacterized protein;;;;;;;;;HELO_2648;uncharacterized protein;-2.173486304771767;0.1651317295121022;0.22685870692898802;1.0806266954948152;3.254113000266582
HELO_2649;1.0523070021089778;11.264008578041313;0.1354751767090401;0.06261937907054717;0.12274026261162944;0.06294289852757523;0.388083258004575;1.1643316007559974;0.23464988922442925;0.10845994608860286;0.10629705239236549;0.10902029822541258;HELO_2649;uncharacterized protein;;;;;;;;;HELO_2649;uncharacterized protein;-2.5791121480028223;0.09523206965550891;0.07896011272602922;0.9491824609561166;3.528294608958939
HELO_2650;1.4489946028052472;15.364552746348538;1.537158803007517;1.3620242790250197;1.0748668632491694;0.8269947636291524;0.02474519809925967;0.9237925874287187;0.8785614870262466;0.16756855472999546;0.34972763164899695;0.5566989876781543;HELO_2650;endolysin;COG4678;Muramidase (phage lambda lysozyme);;HELO_RS09080;MX;;;;HELO_2650;endolysin;-2.7403126735994343;0.4737413227367854;0.18354626782647154;0.42271709538852564;3.16302976898796
HELO_2651;7.863603578867981;4.539839773057574;4.627431895852276;5.356103265536614;4.164962214302163;2.22458867921217;1.1818967453392508;0.6984149711154247;1.0248328506491593;2.7281598735281523;1.3571286592238119;0.6140748828346041;HELO_2651;uncharacterized protein;;;;;;;;;HELO_2651;uncharacterized protein;0.6780491085808831;0.8033615464845876;0.6796426491404155;1.4587782133129124;0.7807291047320293
HELO_2652;1.6704175085931006;2.8304530503678973;0.9574584776465157;1.2001731398350755;0.9832274217310245;0.6535625584818431;0.25189643964616454;0.49989146569644166;0.5815867584719341;0.8864052177336245;0.47788896702678774;0.3544865618373333;HELO_2652;uncharacterized protein;;;;;;;;;HELO_2652;uncharacterized protein;-0.5204497194542848;0.24340407745688286;0.2622724971733392;0.6914876914863083;1.211937410940593
HELO_2653;1.8594294558732016;3.864857597713014;0.8410886127248012;0.6169839583078429;0.7772004051300213;0.38124482578107505;0.551540914476584;0.5733800148391871;0.1905040920385551;0.3784182426795738;0.7660738705136781;0.2067838277384444;HELO_2653;uncharacterized protein;;;;;;;;;HELO_2653;uncharacterized protein;-0.7666702619128776;0.41459000605722235;0.3636373152374917;1.0497582535840402;1.8164285154969178
HELO_2654;2.0310303793357547;5.621315020484705;0.44690843422585597;0.5834760267044256;0.6438510262841667;0.965867793362784;0.39141440925685556;0.8179715518775125;0.06835395670755008;0.468131794882559;0.03780064773215411;0.6028944877372705;HELO_2654;uncharacterized protein;;;;;;;;;HELO_2654;uncharacterized protein;-1.127309458674328;-0.4421926765873857;-0.25808674125668785;0.6246420097916986;1.7519514684660265
HELO_2655;1.9357824853169028;6.312104754575181;1.1349624205008515;1.5100826361342596;1.2089137143233553;1.1904248638087935;0.3373242720418681;0.2766230405070633;0.3761496826581035;0.3669972609610455;0.6521388822544418;0.47014514924482553;HELO_2655;homolog to DNA replication protein DnaC;COG1484;DNA replication protein DnaC;DnaC;HELO_RS09120;L;;;;HELO_2655;homolog to DNA replication protein DnaC;-1.3165416572542694;-0.03700005220281044;0.012126336500949852;0.422534353579868;1.7390760108341374
HELO_2656;1.4137112500895779;9.659318971840401;1.4974460661620794;1.133796338924247;1.657313205401606;1.4985079879963303;0.1720362959988977;0.6838700864029033;0.3732206346938772;0.1595662736632866;0.2291873145034502;0.35581199090659504;HELO_2656;uncharacterized protein;;;;;;;;;HELO_2656;uncharacterized protein;-2.142790263342619;-0.000613308037083593;0.08890145121136106;-0.04981373230890318;2.092976531033716
HELO_2657;0.7132833461106793;6.561304638635526;1.6685507526671668;1.2154706254775418;1.0740403345333405;1.8029127198475081;0.2641613775647964;0.30492273187729013;0.4128005955202143;0.19135652995763203;0.20853486814476482;0.3260845343226953;HELO_2657;YqaJ family protein;COG5377;Phage-related protein, predicted endonuclease;;HELO_RS09160;X;;;;HELO_2657;YqaJ family protein;-2.141871413802651;-0.0708703709245424;-0.43448286987745366;-0.7101630540109334;1.4317083597917177
HELO_2658;1.533444241139598;7.353445315625824;2.269524980591305;1.6830721460307962;1.7417520633558359;2.2504230061038717;0.2897622311275664;0.6284101705398856;0.3108065083546968;0.5096030688798858;0.33667697675817737;0.514519619573627;HELO_2658;uncharacterized protein;;;;;;;;;HELO_2658;uncharacterized protein;-1.7212712722635022;0.008453565203436098;-0.24552936683965454;-0.3595274041683061;1.361743868095196
HELO_2659;4.280596980115727;26.075239922037508;1.9517385444183244;1.152167144924764;1.4096042509172833;4.065921499675609;1.1330037800711306;2.224431378759756;0.8573407377370393;0.1870989740963493;0.6222779244666415;0.7237038734169446;yfdP2;YfdP family protein;;;;;;;;;yfdP2;YfdP family protein;-2.3582011791074837;-0.7792597838273545;-1.072028501298104;0.059876316273458574;2.4180774953809423
HELO_2660;1.9912359914176827;15.083785986384258;3.8391175243317215;1.345422470920458;2.2059615789936298;4.104381454575879;0.5918085012536082;1.13928144377854;0.0934656486944817;0.47145456731975416;0.19042187299151808;1.7620029747015844;yfdQ2;YfdQ family protein;COG5532;Uncharacterized conserved protein YfdQ, DUF2303 family;yfdQ;HELO_RS09175;S;yfdQ2; YfdQ family protein;;yfdQ2;YfdQ family protein;-2.4267934041805836;-0.07699216951861976;-0.6709790109093563;-0.7709944115671044;1.6557989926134793
HELO_2661;1.2503244372392874;4.0879722752905145;1.0032280131793552;0.8363288090736222;0.9284760603049454;1.5623678336744213;0.051147809114999505;0.62598734994183;0.12214670902001684;0.09412181804597156;0.06964971396386235;0.24516335518496477;HELO_2661;DNA-cytosine methyltransferase domain protein;COG0270;DNA-cytosine methylase;Dcm;HELO_RS09180;L;;yfdQ2;;HELO_2661;DNA-cytosine methyltransferase domain protein;-1.176957794411327;-0.3551509504692123;-0.41001635590295926;-0.1873445777806042;0.9896132166307228
HELO_2662;0.9420325879182966;3.4240594192367007;0.9749674710797717;0.2891854363139559;0.48637446803749823;1.0600330113179937;0.38833100362188805;0.33615575836417766;0.059174087513698945;0.2465199364324188;0.2341178035430118;0.2193826628678504;HELO_2662;probable methyltransferase (homolog to DNA-adenine methyltransferase);COG0338;DNA-adenine methylase;Dam;HELO_RS09185;L;;;2.1.1.72;HELO_2662;probable methyltransferase (homolog to DNA-adenine methyltransferase);-1.187803352603002;-0.060838564866673384;-0.4708698309038223;-0.08510004644656044;1.1027033061564415
HELO_2663;0.4843546562686177;2.8477193283286213;0.43691996693888346;0.0;0.23561132072600602;0.6269798863074848;0.14752654484691183;0.4970896829937755;0.15729576979775053;0.0;0.21741529816915256;0.2646817656003067;HELO_2663;uncharacterized protein;;;;;;;;;HELO_2663;uncharacterized protein;-1.374167729938543;-0.17921670635317455;-0.3969714214919553;-0.13236057996862238;1.2418071499699206
HELO_2664;1.0559436247407572;2.6862700175643184;3.173286531407884;3.2421434976196815;3.392898469998792;3.3881518204277925;0.40799208458662933;0.2124886991497689;0.5440334010594206;0.38714434708033335;0.5719699939703478;0.5927345883119994;HELO_2664;uncharacterized protein;;;;;;;;;HELO_2664;uncharacterized protein;-0.8423610461055668;-0.07242946347327361;0.0015597151223198935;-1.0938127352141307;-0.25145168910856386
HELO_2665;1.773290568222518;2.4285887022396397;8.0267485261838;8.152832996298278;7.59748342544495;6.247495997121901;0.321533105339737;0.37281924994867904;1.7399206562318594;1.2930072855720058;1.8569077799883407;0.40818621892079976;HELO_2665;integrase family protein;COG4974;Site-specific recombinase XerD;XerD;HELO_RS09210;L;;;;HELO_2665;integrase family protein;-0.30601606620944977;0.31672378482074803;0.24643179800316828;-1.38588385051482;-1.0798677843053703
HELO_2666;5.5223632536379945;1.9674837875467681;1.2004471656621363;2.575037472874843;1.6163351860287658;0.9234711094099755;1.0271464627318834;0.7506306285349917;0.40597814683876804;1.3705391015049615;0.28569451619153924;0.38097458720018185;HELO_2666;uncharacterized protein;;;;;;;;;HELO_2666;uncharacterized protein;1.1361546442325605;0.1940845715131646;0.4438352199016563;1.7616826316714067;0.6255279874388463
HELO_2667;23.184036362576318;4.622915014319701;12.474408646014064;19.051512939695982;16.15590220756022;12.150482158239802;1.7238526346876186;0.1527975688857767;1.0491889476114167;0.39439341905946657;1.5858168700673199;1.0865594745423433;atvA;V-type ATP synthase subunit A;COG1155;Archaeal/vacuolar-type H+-ATPase catalytic subunit A/Vma1;NtpA;HELO_RS09220;C;atvA; V-type ATP synthase subunit A;7.1.2.2,7.2.2.1;atvA;V-type ATP synthase subunit A;2.1046649062624967;0.035106262088539175;0.3835893009870204;0.8789393568424209;-1.2257255494200758
HELO_2668;26.69470369838825;4.954937104519948;7.821033993314859;12.741500065961374;12.499261836371188;9.161928410337987;0.5290211860203241;0.3994334423569731;0.9120283834950268;1.0060157552190532;0.9339099259600453;0.842543659529803;atvX;V-type ATP synthase subunit X;;;;;;;;;atvX;V-type ATP synthase subunit X;2.217451927724624;-0.20415452349240315;0.40970631464703233;1.4464358977421115;-0.7710160299825124
HELO_2669;31.61743258876169;8.121667904555741;7.770720034502965;12.760952559790516;7.889694654722635;6.870601137374311;2.1575683022452923;0.6083678935184766;0.5697276311284147;3.163321170485706;1.1585874035615193;0.9762534374719629;atvE;V-type ATP synthase subunit E;;;;;;;;;atvE;V-type ATP synthase subunit E;1.8382736762629897;0.15622145647030994;0.17566003640516392;2.051097493281076;0.21282381701808628
HELO_2670;25.027249293862138;4.263842936580244;8.564091131647046;11.514166300676253;10.834360186380449;9.655351545910712;0.816186321938424;0.43444892589834055;0.8760538401824592;1.489125854576106;2.244618270710974;1.4406050475721508;atvK;V-type ATP synthase subunit K;;;;;;;;;atvK;V-type ATP synthase subunit K;2.3058345002160388;-0.15587840993875535;0.15140351830528065;1.2884446557528118;-1.017389844463227
HELO_2671;24.874644926881174;4.643551528098563;7.837151731954162;11.332939337014034;9.568411748632798;7.274461374553359;1.2465090719333316;0.17651012774771113;0.2634527390978882;1.1827724568619185;0.4743660009728504;0.47704816870972544;atvI;V-type ATP synthase subunit I;COG1269;Archaeal/vacuolar-type H+-ATPase subunit I/STV1;NtpI;HELO_RS09240;C;atvI; V-type ATP synthase subunit I;;atvI;V-type ATP synthase subunit I;2.1968638128704443;0.09491605225062383;0.353021272680361;1.6448017569393363;-0.552062055931108
HELO_2672;24.653949900355332;4.0743212235095845;6.2022235277486155;8.691803612439271;5.571889325773443;4.951353485946091;1.3454591493371797;0.3776409722825473;0.6353813981513233;2.045413859926172;0.13939474617533512;0.8777017557797172;atvD;V-type ATP synthase subunit D;COG1394;Archaeal/vacuolar-type H+-ATPase subunit D/Vma8;NtpD;HELO_RS09245;C;atvD; V-type ATP synthase subunit D;;atvD;V-type ATP synthase subunit D;2.337894217138973;0.27522456510891447;0.14309037421041637;2.1078912569177946;-0.2300029602211784
HELO_2673;40.23671913853164;9.491374411901967;17.542036725129524;26.797870482315826;18.5006331129909;17.959097593068503;0.6486212298557632;0.23296903560524967;1.1825495691843373;2.250666925591823;0.48497824619966545;1.7644610265162988;atvB;V-type ATP synthase subunit B;COG1156;Archaeal/vacuolar-type H+-ATPase subunit B/Vma2;NtpB;HELO_RS09250;C;atvB; V-type ATP synthase subunit B;;atvB;V-type ATP synthase subunit B;1.9747258649703254;-0.03209057352805722;0.040630666579174246;1.1210392569767382;-0.8536866079935872
HELO_2674;58.79113448330528;7.807798216534643;15.94239428953292;26.567680508869486;21.59179475308103;17.638937973733817;2.513836156391325;0.5394895229299378;0.839173600566424;0.1524503824209041;3.3791676242346917;2.6933648652891757;arcC;carbamate kinase;COG0549;Carbamate kinase;ArcC;HELO_RS09255;E;arcC; carbamate kinase;2.7.2.2;arcC;carbamate kinase;2.7630782622330847;-0.13768188923016655;0.277479227716098;1.6816119258549014;-1.0814663363781833
HELO_2675;62.85736443705023;10.869221546451465;20.63351203019093;29.269191247521942;24.54392895068059;20.903589898530253;1.9001816364224733;0.164633215890367;1.2596825169415535;3.165915049645672;1.502588427699119;1.4670803262865018;arcB;ornithine carbamoyltransferase;COG0078;Ornithine carbamoyltransferase;ArgF;HELO_RS09260;E;arcB; ornithine carbamoyltransferase;2.1.3.3;arcB;ornithine carbamoyltransferase;2.4276276926491436;-0.017899445861957908;0.221813104887727;1.5436856699371004;-0.8839420227120431
HELO_2676;61.018160176916886;9.179360088823506;20.032169583390992;29.690781038304163;22.140645993064908;18.348980269501173;0.2868603724752617;0.3016446422559978;0.20997724082941072;3.901353947412287;1.369999027779419;1.503646089678478;arcA;arginine deiminase;COG2235;Arginine deiminase;ArcA;HELO_RS09265;E;arcA; arginine deiminase;3.5.3.6;arcA;arginine deiminase;2.607043856505935;0.12034014421592332;0.25817160378816606;1.6804331923535827;-0.9266106641523524
HELO_2677;56.33602969405424;8.30396434132446;15.136690031147715;25.522440251954787;12.419025026926557;14.852387316532651;5.170334544181611;1.0597792767182563;2.046614724459117;1.1274496696934657;0.6793361900937743;0.859854707981312;arcD;APC family transport protein (probable arginine/ornithine antiporter);COG0531;Serine transporter YbeC, amino acid:H+ symporter family;PotE;HELO_RS09270;E;arcD; APC family transport protein (probable arginine/ornithine antiporter);;arcD;APC family transport protein (probable arginine/ornithine antiporter);2.6235245341785087;0.025644560596250532;-0.2404202669231088;1.8547418850170572;-0.7687826491614516
HELO_2678;3.595362302750889;4.105315226629286;8.712902249821896;9.35619366183749;8.211869848543943;7.268404221153003;0.6946796522215936;0.5205302567657363;2.7797182541000667;1.0209291740137485;1.4842563565692726;0.7250585284003153;HELO_2678;uncharacterized protein;;;;;;;;;HELO_2678;uncharacterized protein;-0.1518214333065493;0.2322935223224163;0.1558851077534027;-0.8474303107086079;-0.6956088774020586
HELO_2679;428.3271002401728;47.048140168257675;154.03808597866828;149.91896419606988;101.83082490769577;127.16245884595634;109.77528040223099;9.29904274458215;34.73194524601015;41.62371189894553;14.889515915791273;20.464399640078064;HELO_2679;UPF0057 family protein;COG0401;Membrane potential modulator PMP3/YqaE, plasma membrane proteolipid 3 (PMP3)/Esi3/RCI2/UPF0057 family;YqaE;HELO_RS09280;C;;;;HELO_2679;UPF0057 family protein;3.159524748489937;0.2746489334138067;-0.31770093538888666;1.7441035105303584;-1.4154212379595785
HELO_2680;62.12346423802911;13.78250645196978;25.33865681326236;28.022585699183264;23.74532931339;24.971518874986696;1.0199152298077632;0.5286719412189177;1.747107037898119;0.4276430139352711;1.2713179331528721;2.6831619283514594;HELO_2680;DUF21 / CBS domain protein;COG1253;Hemolysin-related protein, contains CBS domains, UPF0053 family;TlyC;HELO_RS09285;R;;;;HELO_2680;DUF21 / CBS domain protein;2.0942854763567467;0.020251386012207107;-0.06977414678696459;1.2812459944840615;-0.8130394818726852
HELO_2681;750.9850435009499;197.57856722273496;767.7786221373002;939.0065046104943;612.7528318888977;721.7285822679032;119.8611068289442;52.42148445418532;64.00734113695827;121.06075664908194;54.617581375086104;155.91419905523034;HELO_2681;UPF0410 family protein;COG2261;Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family;YeaQ;HELO_RS09290;R;;;;HELO_2681;UPF0410 family protein;1.9209940481170404;0.08911426810519174;-0.23579617460993063;0.05725001718555056;-1.8637440309314899
HELO_2682;67.30691021543596;24.651779240267377;39.00668183895489;55.01316243029015;38.72617990748499;34.516309805903724;1.0807049150981465;1.9291587543823403;0.8645080671087874;1.8113379078570664;1.1330195620904406;3.288576934710523;nhaP;NHE family potassium/proton antiporter NhaP;COG3263;NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains;NhaP2;HELO_RS09295;CP;nhaP; NHE family potassium/proton antiporter NhaP;;nhaP;NHE family potassium/proton antiporter NhaP;1.4129726385408414;0.17175928482259373;0.1616083782543667;0.9435498435708016;-0.4694227949700398
HELO_2683;38.835566676324994;28.135513190890862;43.16927743381018;52.79088336149601;46.1082451599483;43.23919940399913;1.0410451729543113;2.037691929306519;6.29443591238213;7.725752895453546;4.885653707563844;3.381848132102284;HELO_2683;THI5 family protein;COG0715;ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component;TauA;HELO_RS09300;P;;nhaP;;HELO_2683;THI5 family protein;0.4512783755203831;-0.0022820458915742137;0.09065431346023534;-0.1512681794235613;-0.6025465549439444
HELO_2684;110.83070506637314;140.14687080382564;185.27859837355754;227.21018923093163;252.67839163293607;183.50767096152683;4.842648965406838;5.904737264044032;9.10124848802626;14.597392394612536;12.04254709936778;10.231602581548199;HELO_2684;alpha/beta hydrolase fold protein;COG0596;2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold;MenH;HELO_RS09305;HR;;;3.1.-.-;HELO_2684;alpha/beta hydrolase fold protein;-0.33588078529567067;0.01378113395122238;0.45931983762510153;-0.7223644384062169;-0.3864836531105462
HELO_2685;95.69213573824273;115.17221038897657;122.87689786426252;168.9751105116295;132.54132140757645;123.31915873090914;2.669022695676363;9.450792175705278;18.733518112536753;16.136793433318736;11.897257346535545;9.460631201628141;HELO_2685;DUF165 domain protein;COG1738;Queuosine precursor transporter YhhQ, DUF165 family;YhhQ;HELO_RS09310;J;;;;HELO_2685;DUF165 domain protein;-0.26479454136293956;-0.0051414856718361435;0.1032375748982588;-0.3625781852920644;-0.09778364392912486
HELO_2686;17.132855267037087;12.44927153257533;21.757011528004664;28.632633061152124;96.8554760311179;20.07667016555852;1.8655900547326143;0.3495883527178268;2.7044879474504966;2.3950411361217054;5.4630397437938205;2.2745321629978257;prpE;propionate--CoA ligase;COG0365;Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase;Acs;HELO_RS09315;I;prpE; propionate--CoA ligase;6.2.1.17;prpE;propionate--CoA ligase;0.431078082465036;0.11066415573437638;2.215005628606434;-0.21704084317650008;-0.6481189256415361
HELO_2687;26.365204605576064;4.563562678583266;24.25114763083579;51.03440450233754;38.41300084175846;19.887021535225788;3.2692714224956325;1.0500335354461592;3.5077053653558403;2.4847292259744016;5.3511158097135505;2.7622446793329565;HELO_2687;ArsR family transcription regulator;COG0640;DNA-binding transcriptional regulator, ArsR family;ArsR;HELO_RS09320;K;;prpE;;HELO_2687;ArsR family transcription regulator;2.2982617163672203;0.27374217746058527;0.9160648176597661;0.38973586295156437;-1.908525853415656
HELO_2688;122.20284144407077;87.44907161614765;92.5414159029043;127.16476397289857;113.8675329989789;79.0974321524258;5.800983195987088;5.528134836513616;11.335838774243225;15.580398007434097;9.694711671727479;1.6248913985235496;sohB;probable protease SohB;COG0616;Periplasmic serine protease, ClpP class;SppA;HELO_RS09325;O;sohB; probable protease SohB;3.4.21.-;sohB;probable protease SohB;0.4781166242752066;0.2238492745371108;0.5201431846503564;0.6212076324348974;0.14309100815969078
HELO_2689;87.3776582905826;47.396273801928594;101.39650007631616;104.19087123863294;105.96260264453498;100.13919984214185;1.334738738690264;6.685987430182966;6.842514812060922;3.0656474032353236;8.567094620318535;9.93837353778314;HELO_2689;sterol-binding domain protein;COG3255;Putative sterol carrier protein, contains SCP2 domain;SCP2;HELO_RS09330;I;;sohB;;HELO_2689;sterol-binding domain protein;0.8687857314078338;0.017824134893395183;0.08076420522656669;-0.19458865964274796;-1.0633743910505817
HELO_2690;149.6224808233202;91.246767215372;107.95012040756198;133.49731070430406;114.82961148698833;101.56406118566468;4.869895322545703;0.9785031725112046;8.187554367790295;0.5938915708693507;10.713220069726596;8.961381725024978;nudC;NADH pyrophosphatase;COG2816;NADH pyrophosphatase NudC, Nudix superfamily;NPY1;HELO_RS09335;F;nudC; NADH pyrophosphatase;3.6.1.22;nudC;NADH pyrophosphatase;0.7073668543436256;0.08714249688237974;0.17547882708280227;0.5544118183351143;-0.15295503600851124
HELO_2691;218.1957392422571;175.09055374844903;144.87640307937605;173.44739176351155;147.23594424147805;150.00177951113193;13.672167717323026;10.228032299947493;4.251810081471024;6.688917011433396;2.821874246251614;6.321797746886378;dnaQ;DNA polymerase 3 epsilon subunit;COG0847;DNA polymerase III, epsilon subunit or related 3'-5' exonuclease;DnaQ;HELO_RS09340;L;dnaQ; DNA polymerase 3 epsilon subunit;2.7.7.7;dnaQ;DNA polymerase 3 epsilon subunit;0.31590223635759873;-0.04981901914603526;-0.026670236726412;0.5376542038778043;0.22175196752020554
HELO_2692;284.3111596698582;198.81059972775384;152.28490197979144;186.68223988628327;132.68055004116096;149.67659817079627;9.210135395175792;2.700824488513596;7.5010050761257006;17.837557948179132;2.661867743700091;4.621003180431145;rnhA;ribonuclease H;COG0328;Ribonuclease HI;RnhA;HELO_RS09345;L;rnhA; ribonuclease H;3.1.26.4;rnhA;ribonuclease H;0.5139030591324776;0.024760236635341215;-0.17266579237676183;0.9210808106386299;0.4071777515061523
HELO_2693;179.2086012856363;53.133238449774524;111.70156315011509;165.59277273256745;123.06032468314179;112.87853778449477;9.093651071333168;2.5089711149215983;4.5456223735687855;10.928059697661245;8.95666551180069;6.651032655530714;HELO_2693;probable S-adenosylmethionine-dependent methyltransferase;;;;;;;;;HELO_2693;probable S-adenosylmethionine-dependent methyltransferase;1.7350812689817197;-0.0149883483505171;0.12354593184465124;0.6621719981451175;-1.0729092708366021
HELO_2694;177.67913402875456;202.60329528229514;226.66421407042074;234.88683670287207;289.1984596813654;228.12948567114347;10.785649814118461;16.843888235808826;10.305854915308224;4.3497704811207765;43.26810708931607;23.552366350954696;gloB;hydroxyacylglutathione hydrolase;COG0491;Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II;GloB;HELO_RS09355;R;gloB; hydroxyacylglutathione hydrolase;3.1.2.6;gloB;hydroxyacylglutathione hydrolase;-0.1883897436329054;-0.009255588786144742;0.3408767371694763;-0.3587919569761615;-0.17040221334325611
HELO_2695;130.4539246785147;165.35223360139173;156.6475695450911;145.45524250257506;196.059415713848;167.10268822426573;4.585865178579834;0.3604699798165546;11.405473740030484;6.634254787712675;11.411541271420724;7.929565263113305;HELO_2695;MltD family protein;COG4623;Membrane-bound lytic murein transglycosylase MltF;MltF;HELO_RS09360;TM;;gloB;4.2.2.-;HELO_2695;MltD family protein;-0.33968402173610546;-0.09263986756127274;0.22928788896228713;-0.3547855801093247;-0.015101558373219248
HELO_2696;59.353205712807885;59.1042478941231;38.22697270021417;31.178886175947202;40.704342085058194;37.39235010100675;3.5637333491566885;1.4569705952380412;4.067956606577378;2.480286661878989;1.2594801282937964;3.1103085166717537;HELO_2696;ABC-type transport system periplasmic substrate-binding protein;COG4166;ABC-type oligopeptide transport system, periplasmic component;OppA;HELO_RS09365;E;;;;HELO_2696;ABC-type transport system periplasmic substrate-binding protein;0.005963445366916176;0.031027127053103953;0.11937872477415734;0.6526115288058358;0.6466480834389197
HELO_2697;25.492129577184304;16.549576659039445;11.914723805282222;16.697930239769658;14.429255110457609;11.39818255019786;1.0818721103281246;0.6971369375913413;1.0749333662023752;1.457837551395559;0.8894436673485483;0.8541803186815607;HELO_2697;ABC-type transport system permease protein;COG4174;ABC-type microcin C transport system, permease component YejB;YejB;HELO_RS09370;Q;;;;HELO_2697;ABC-type transport system permease protein;0.5941275903782266;0.05888813884162669;0.3155397621165297;1.0954351683904928;0.5013075780122662
HELO_2698;20.987425758334968;11.067469060146623;10.413668486581816;13.965207760064084;15.49562839223554;10.999694051239054;1.3506478150426002;1.3270166134360033;0.7293397886825232;1.0691064250305982;0.9559203330993998;0.9180276842714626;HELO_2698;ABC-type transport system permease protein;COG4239;ABC-type microcin C transport system, permease component YejE;YejE;HELO_RS09375;Q;;;;HELO_2698;ABC-type transport system permease protein;0.8655555785189;-0.07223505757537163;0.4590861148523766;0.8736810835705002;0.008125505051600257
HELO_2699;40.85912744440785;21.4133944139116;26.851195510934122;39.2705282577978;40.813779852726135;29.987015565425736;1.9405211169475853;0.6974369375468075;1.6002531917028961;1.136057170422857;2.338714531414758;2.0360227537092093;HELO_2699;ABC-type transport system ATP-binding protein;COG4172;ABC-type microcin C transport system, duplicated ATPase component YejF;YejF;HELO_RS09380;Q;;;;HELO_2699;ABC-type transport system ATP-binding protein;0.9011810833924292;-0.1539245556643447;0.4323146528519999;0.43387842669837884;-0.46730265669405036
HELO_2700;81.09192582452;9.523758772493936;19.98796083711782;25.972383152990208;23.076644731188168;18.354652009143184;3.7338004438040944;0.6432409821715198;1.1817897494532432;1.1808195626988407;1.663459762165833;1.6696568108808303;HELO_2700;DUF2219 family protein;COG3528;Uncharacterized conserved protein, DUF2219 family;;HELO_RS09385;S;;;3.1.1.-;HELO_2700;DUF2219 family protein;2.963590248007985;0.11688163443390742;0.3149539866262643;2.084559963648325;-0.87903028435966
HELO_2701;3.0718800098781203;0.6177506391660553;1.2992302840068373;2.691743155359072;2.1003113352286804;1.1512871895089092;0.3371485444527906;0.13584759492102289;0.09533131786699987;0.1105767391861523;0.11469204816964457;0.21217169436768135;HELO_2701;diguanylate cyclase;COG2199;GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants;GGDEF;HELO_RS09390;T;;;;HELO_2701;diguanylate cyclase;1.3317058014940688;0.09595083681026084;0.5272129666351848;0.9204949162268561;-0.41121088526721283
HELO_2702;118.45978215843252;64.90461632944498;82.30671937360388;104.22383523903704;94.62506002750585;84.69308017213058;3.996526325181839;4.044598122458454;5.209494759863259;1.12178721386095;6.362619461953137;3.509632416412366;rsuA;16S rRNA pseudouridine(516) synthase RsuA;COG1187;Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605;RsuA;HELO_RS09395;J;rsuA; 16S rRNA pseudouridine(516) synthase RsuA;5.4.99.19;rsuA;16S rRNA pseudouridine(516) synthase RsuA;0.8580735677117204;-0.04074584400611592;0.1582100387906724;0.4792743814101019;-0.37879918630161846
HELO_2703;104.70693760687827;57.468356795652426;78.20611713911062;81.13186578256636;74.01514160724949;73.0353183668662;3.6268474644027306;1.9442938005311556;7.618225044004252;4.590378539887421;4.01918695052129;2.7945040667804206;HELO_2703;carbon-nitrogen hydrolase domain protein;COG0388;Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate;Nit2;HELO_RS09400;C;;rsuA;3.5.1.3;HELO_2703;carbon-nitrogen hydrolase domain protein;0.8543421134701052;0.09739818578744686;0.018968160085702124;0.513784490535933;-0.34055762293417224
HELO_2704;61.563950538110795;17.95856220384526;53.433419333328004;48.34592796370671;41.47512408010482;51.655365876282964;2.516863477130074;0.19808369980355214;8.143837542531886;4.774503199913971;3.7366292556600875;2.757348326711524;HELO_2704;RarD family protein;COG2962;Membrane protein RarD, contains two EamA domains, drug/metabolite transporter family;RarD;HELO_RS09405;R;;;;HELO_2704;RarD family protein;1.7224820570512023;0.0479121069622126;-0.309962395559535;0.24875105562145539;-1.473731001429747
HELO_2705;57.63321151234174;18.770717236291933;34.81569558742791;38.42456984046196;33.09273902585635;35.790070047027434;4.600682569877023;1.7146436253593784;3.9165286877528493;2.196282258603667;2.525890115316683;5.7014843559810755;HELO_2705;sulfate transport domain protein;COG0659;Sulfate permease or related transporter, MFS superfamily;SUL1;HELO_RS09410;P;;;;HELO_2705;sulfate transport domain protein;1.5683528698371934;-0.038724461817385425;-0.10985191225818003;0.6724016563668034;-0.89595121347039
HELO_2706;47.60518186366682;15.12262162868368;24.43518515496915;34.587244233478664;35.6711567103977;23.969329713972517;0.7141395994610631;1.6615331772973805;1.69072673696671;2.0239732287671277;1.945131660245643;2.9430950737390447;HELO_2706;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS09415;T;;;2.7.13.3;HELO_2706;sensor histidine kinase;1.5920237764405778;0.026668502770592184;0.5544886798456705;0.9609530361443044;-0.6310707402962734
HELO_2707;98.23564801003813;34.70676314158873;71.8530082959664;89.49647534861832;116.70491255642827;69.07251216278091;2.3901220525050872;3.951426278675991;1.2291518080146977;9.884643259448083;11.063596436434462;7.965907114348973;HELO_2707;response regulator/HTH domain transcription regulator;COG4567;DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains;;HELO_RS09420;KT;;;;HELO_2707;response regulator/HTH domain transcription regulator;1.4746611091559245;0.05613992718710037;0.7482540100595978;0.5020098479947643;-0.9726512611611602
HELO_2708;218.30281269044085;159.51600886614224;159.7858761272989;145.85750098645335;137.08287904426402;151.57238171512813;3.2373308394814124;3.587330342010222;12.832340728337169;13.61418245762367;12.984615608922242;11.39168354846921;HELO_2708;phosphoribosyltransferase domain protein;COG0634;Hypoxanthine-guanine phosphoribosyltransferase;HptA;HELO_RS09425;F;;;2.4.2.8;HELO_2708;phosphoribosyltransferase domain protein;0.45020712562810505;0.07564684916370101;-0.14395938232219407;0.5234304829350371;0.07322335730693208
HELO_2709;242.07117737225596;178.63397321388766;184.36722539303787;188.78742528628985;157.59080592583248;192.50052038708623;15.110731012594044;3.948485760468039;4.91444414520382;4.9451786209789015;19.36927521906312;12.175678460279904;nagZ;beta-hexosaminidase;COG1472;Periplasmic beta-glucosidase and related glycosidases;BglX;HELO_RS09430;G;nagZ; beta-hexosaminidase;3.2.1.52;nagZ;beta-hexosaminidase;0.4363186081056085;-0.061951261319554085;-0.28702831096688275;0.32904138693606644;-0.10727722116954208
HELO_2710;66.96217091211678;47.48947127200912;54.37098170098644;66.7173034898504;54.60828831378438;57.81016365821279;7.997448125098845;1.9083046380761854;4.48338703278438;2.6349604057037466;1.8312578535524986;4.687719828189235;pilD;prepilin peptidase;COG1989;Prepilin signal peptidase PulO (type II secretory pathway) or related peptidase;PulO;HELO_RS09435;NU;pilD; prepilin peptidase;3.4.23.43,2.1.1.-;pilD;prepilin peptidase;0.4870604144822863;-0.08693540488164597;-0.08076557523321526;0.20866643192256706;-0.27839398255971926
HELO_2711;79.17900117154339;55.062416822051524;61.51790705384615;70.1717202733286;77.25230192521173;73.58924431105909;3.7862184968163257;4.300425709394333;7.401704663977321;8.572730092974423;2.5075030196523156;2.09147864602671;coaE;dephospho-CoA kinase;COG0237;Dephospho-CoA kinase;CoaE;HELO_RS09440;H;coaE; dephospho-CoA kinase;2.7.1.24;coaE;dephospho-CoA kinase;0.5161905056985523;-0.25469812914707735;0.06916558160753716;0.10425683485079684;-0.41193367084775545
HELO_2712;71.32954881876019;50.032651762206775;52.57666557454104;54.69009683181338;48.80123532847438;54.12800328234306;1.6388257552371457;8.518589759867023;13.551473038961534;5.006845690869554;15.571969183258288;5.692751939047323;yacG;DNA gyrase inhibitor YacG;COG3024;Endogenous inhibitor of DNA gyrase, YacG/DUF329 family;YacG;HELO_RS09445;L;yacG; DNA gyrase inhibitor YacG;;yacG;DNA gyrase inhibitor YacG;0.5031645432767062;-0.04118055279927102;-0.1466038194047128;0.39179980391888325;-0.11136473935782298
HELO_2713;93.49042593941614;80.16640711361129;66.48526259301919;66.06932932357653;75.46539811154175;66.59868121711973;3.0929662329853245;1.9081298889889438;5.58218220684324;1.175079451175515;1.2051882895037955;1.4223142909811899;HELO_2713;uncharacterized protein;;;;;;;;;HELO_2713;uncharacterized protein;0.21928540539327113;-0.002422619896477407;0.17781195027773666;0.48317305719993264;0.2638876518066615
HELO_2714;845.283204396815;697.043537825207;833.1600137179818;1017.9722881514023;742.5730360518356;772.709319531414;53.34834599791098;62.77172293678679;52.618070436393474;89.61024292836494;30.30807055797529;83.28155851452837;HELO_2714;uncharacterized protein;;;;;;;;;HELO_2714;uncharacterized protein;0.27782351286115414;0.10853250528400338;-0.05731719636965238;0.12934888315570348;-0.14847462970545067
HELO_2715;6045.204751117058;7843.366561930391;2660.9254982375064;2096.465890761981;2012.3215566091487;1968.7447605979505;507.7432728934071;701.3870767840733;594.6065655051308;1009.3161601669152;257.80880843515865;539.2302463089883;HELO_2715;H-NS domain protein;;;;;;;;;HELO_2715;H-NS domain protein;-0.3756271174664718;0.43446149631879294;0.03156891249257221;1.6180211383396372;1.993648255806109
HELO_2716;4486.9791440350955;4863.473591813014;4145.133589433352;4128.892489794599;4913.761878092438;4169.744630303111;197.8015379785516;406.3943578938782;270.68716108269206;281.11127342762745;262.2661362047602;142.84399605599708;rpsA;30S ribosomal protein S1;COG0539;Ribosomal protein S1;RpsA;HELO_RS09465;J;rpsA; 30S ribosomal protein S1;;rpsA;30S ribosomal protein S1;-0.1162177207995505;-0.008538379260873086;0.23681653874453445;0.10576099121126603;0.22197871201081654
HELO_2717;482.9327115613321;370.6279782823897;1471.1168306792413;1509.612345180969;1747.7877505478962;1640.5067460564012;45.3454918335419;51.41539648119156;96.0605343862651;27.909951918383616;149.61323342290734;287.8877587534118;cmk;cytidylate kinase;COG0283;Cytidylate kinase;Cmk;HELO_RS09470;F;cmk; cytidylate kinase;2.7.4.25;cmk;cytidylate kinase;0.3809473417148972;-0.15712850729353534;0.09133452181575663;-1.762142311946974;-2.143089653661871
HELO_2718;253.55863850915014;244.26994599279865;368.97877951765923;389.47339280841135;412.13770665414194;366.7369537850811;6.586055271541427;9.841498578315715;6.391589104671879;9.141164018434011;22.83213325930788;19.552703839928718;aroA;prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase;COG0287;Prephenate dehydrogenase;TyrA;HELO_RS09475;E;aroA; prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase;1.3.1.43,1.3.1.12,2.5.1.19;aroA;prephenate dehydrogenase / 3-phosphoshikimate 1-carboxyvinyltransferase;0.05362755969343702;0.008768366125005755;0.1679485796449658;-0.5306761352141827;-0.5843036949076197
HELO_2719;192.26250689511747;199.97643392714053;356.4664818235271;364.50403232645596;412.2241106153252;338.6370984320659;10.04922654162635;17.662909376336433;22.30521099034585;16.897861633347834;53.97394668714789;30.207803468183364;pheA;chorismate mutase / prephenate dehydratase;COG1605;Chorismate mutase;PheA;HELO_RS09480;E;pheA; chorismate mutase / prephenate dehydratase;5.4.99.5,4.2.1.51;pheA;chorismate mutase / prephenate dehydratase;-0.05646456341936279;0.07381392006029053;0.2829303818500932;-0.8134322720090559;-0.7569677085896931
HELO_2720;238.4313919833779;261.22091319963937;339.6357551487642;386.14562566739914;369.3008803609329;335.4377158622107;6.196381323340934;15.377639164973049;6.895066007351891;24.703522681102363;20.594448926210454;5.888617015334769;serC;phosphoserine aminotransferase;COG1932;Phosphoserine aminotransferase;SerC;HELO_RS09485;EH;serC; phosphoserine aminotransferase;2.6.1.52;serC;phosphoserine aminotransferase;-0.13117043379554172;0.017890430896784437;0.1383585335121822;-0.4907271286602013;-0.3595566948646596
HELO_2721;333.7640939601416;266.25875158721885;370.1182040994175;412.2705041606496;400.70695125396225;374.24289971262033;3.538241502019716;10.586883812767855;19.894588077629123;2.1515273452959627;29.83290351922688;19.27703831401398;gyrA;DNA gyrase subunit A;COG0188;DNA gyrase/topoisomerase IV, subunit A;GyrA;HELO_RS09490;L;gyrA; DNA gyrase subunit A;5.6.2.2;gyrA;DNA gyrase subunit A;0.324907605133113;-0.0159460037702992;0.09831865275951301;-0.16467997767673914;-0.48958758280985215
HELO_2722;12.832440799270296;7.425510204275835;28.829193887118368;24.865914634309963;31.777072455814857;30.623452718720575;0.9395152957861566;0.718151742614266;1.0967229460632877;4.1552858906924754;2.2140151753952773;0.5614796286765804;fadM;long-chain acyl-CoA thioesterase FadM;COG0824;Acyl-CoA thioesterase FadM;FadM;HELO_RS09495;I;fadM; long-chain acyl-CoA thioesterase FadM;3.1.2.-;fadM;long-chain acyl-CoA thioesterase FadM;0.7152197932565807;-0.08426990255478728;0.0516921103039687;-1.1929391436609587;-1.9081589369175394
HELO_2723;296.00834012994574;292.98720421088063;358.1413073344059;320.4893419412342;316.06814278020465;361.4684907760395;13.74057699759398;6.335478769860634;1.3928844207968352;10.828615104828819;11.471240244124331;13.087678880072557;rdgC2;recombination-associated protein RdgC;COG2974;DNA recombination-dependent growth factor RdgC;RdgC;HELO_RS09500;L;rdgC2; recombination-associated protein RdgC;;rdgC2;recombination-associated protein RdgC;0.014750079985171638;-0.013303990827226997;-0.19306265688540947;-0.2873521446119458;-0.30210222459711744
HELO_2724;125.10189798601009;166.44009270730916;138.82075676415585;115.36648806249781;123.63336349454369;144.90665279587623;6.123971816003229;4.268506089030582;8.011224948919223;4.168576544551302;3.976519416174823;5.576125322144185;HELO_2724;acyltransferase domain protein;COG0204;1-acyl-sn-glycerol-3-phosphate acyltransferase;PlsC;HELO_RS09505;I;;rdgC2;;HELO_2724;acyltransferase domain protein;-0.4090550253559364;-0.06146711769822577;-0.22735534662949597;-0.2104556761019314;0.19859934925400502
HELO_2725;89.1001568494557;61.83660852218137;49.165414500615135;47.61604022603714;47.770023848146195;52.43240190078638;3.952715510090703;1.4841121521794314;2.4415473059327;3.3172305592751554;0.8527837551837721;6.060339078663989;HELO_2725;cation diffusion facilitator family transport protein;COG0053;Divalent metal cation (Fe/Co/Zn/Cd) efflux pump;FieF;HELO_RS09510;P;;;;HELO_2725;cation diffusion facilitator family transport protein;0.5199243013239494;-0.09102179998763127;-0.13172019300702154;0.7538147466870564;0.233890445363107
HELO_2726;904.3457451812247;469.2204585585161;577.6200314613102;548.8021680936852;560.1212145763935;589.0702611470973;52.081890189434354;45.77568095973392;8.757201852799385;74.74007520837239;46.056022532586425;20.292643964453866;HELO_2726;uncharacterized protein;;;;;;;;;HELO_2726;uncharacterized protein;0.9451315427618461;-0.028270480696130917;-0.0725742915264238;0.6175821025061694;-0.32754944025567667
HELO_2727;67.68250062884992;94.31510146831698;104.90063502164458;157.3286118162168;123.56032281365572;102.96841042008431;4.431478055902964;2.4969535279469826;3.520108982456448;6.516760604715332;6.300861609705901;3.101595736475239;thiI;tRNA sulfurtransferase;COG0607;Rhodanese-related sulfurtransferase;PspE;HELO_RS09520;P;thiI; tRNA sulfurtransferase;2.8.1.4;thiI;tRNA sulfurtransferase;-0.4727622422654507;0.026565991311179538;0.2606993394501007;-0.5981307771951121;-0.12536853492966138
HELO_2728;147.41029672319053;152.04120639926592;251.66394422914126;244.96349323614473;257.6625528372822;249.80062836969225;6.378723583499245;10.180241352675331;17.331675443840226;12.982844425223094;37.30155436729506;32.450952856821075;metG;methionine--tRNA ligase;COG0143;Methionyl-tRNA synthetase;MetG;HELO_RS09525;J;metG; methionine--tRNA ligase;6.1.1.10;metG;methionine--tRNA ligase;-0.04432896159848987;0.01067884006195019;0.044530244164313615;-0.7569497729755641;-0.7126208113770742
HELO_2729;157.63754346981483;159.5078180173496;187.08207511667277;206.9619188334124;182.247256988217;196.53724593894603;8.695872588543113;14.876256033317413;3.1719962513185043;17.455664906778452;7.950881748134473;25.485674916807174;rnfB;electron transport complex subunit RnfB;COG2878;Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit;RnfB;HELO_RS09530;C;rnfB; electron transport complex subunit RnfB;7.2.1.2;rnfB;electron transport complex subunit RnfB;-0.01690932740536155;-0.07076233971443457;-0.108333098267134;-0.31639045874833727;-0.2994811313429757
HELO_2730;81.28143391333057;74.14625372477808;117.85352163524904;140.0550235412721;134.40043933170114;117.79612580089592;2.9470058900133917;5.395689113838462;10.17982916847343;8.436429053608366;17.38386320824488;12.088085661072576;nth;endonuclease 3;COG0177;Endonuclease III;Nth;HELO_RS09535;L;nth; endonuclease 3;4.2.99.18;nth;endonuclease 3;0.13086575275186618;0.0006968635391819689;0.18874463251655804;-0.5298489465445808;-0.660714699296447
HELO_2731;86.36864110778409;112.78413230684934;46.55939306121257;52.65741993229321;37.13862919809716;48.19500819674487;3.710072516673115;4.459763877647074;7.906547129668827;8.90077564513677;3.9577938627952425;1.8175498735068962;HELO_2731;uncharacterized protein;;;;;;;;;HELO_2731;uncharacterized protein;-0.38111192482799616;-0.048781629185204345;-0.3672589427862052;0.8286036184773975;1.2097155433053937
HELO_2732;79.01737316827789;89.54105988174183;36.86749442141795;29.067717157102873;22.779288633445336;35.36751778705982;1.2963190451418543;1.5891722015580523;3.326731990745117;0.7047915866220915;1.9629898952085187;2.1841106730389943;HELO_2732;YedE family protein;;;;;;;;;HELO_2732;YedE family protein;-0.17825892671940746;0.05830950550844971;-0.612944903113358;1.1376628082162403;1.3159217349356478
HELO_2733;87.12424603109146;119.39943709889879;58.764879366758386;47.48403610488865;33.06444440562605;52.458615265486635;1.3884669686646502;1.359829603974189;2.2249042848752847;4.418398827239376;0.28216731900191094;8.182266263559146;HELO_2733;rhodanese domain protein;COG2897;3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains;SseA;HELO_RS09550;P;;;2.8.1.1,2.8.1.2;HELO_2733;rhodanese domain protein;-0.45021773288193145;0.16087547042625694;-0.6501557915806506;0.7211165410720666;1.171334273953998
HELO_2734;78.20647044391508;49.991660453099264;43.32747969780871;54.671189349723186;46.627701846354945;43.40985894736509;1.6081568478923063;0.9002960325293037;2.5682359474686183;2.3265798807910607;1.1276011961321735;2.3836694107131597;HELO_2734;ArsA family protein;COG0003;Anion-transporting ATPase, ArsA/GET3 family;ArsA;HELO_RS09555;P;;;7.3.2.7,7.3.-.-;HELO_2734;ArsA family protein;0.6353569725636241;-0.002678650740806532;0.10092094771271931;0.8347383010155554;0.19938132845193124
HELO_2735;105.37798171239037;66.51948602221422;41.15563826579605;46.49644386453638;45.89937401652645;40.70030130191046;2.8409459699196593;1.2536234227320706;8.071808452829357;2.0506311898904666;12.302562478665374;7.141944600415992;HELO_2735;uncharacterized protein;;;;;;;;;HELO_2735;uncharacterized protein;0.6558237433840812;0.01566779501944726;0.1695108589037515;1.3510698574850695;0.6952461141009882
HELO_2736;99.99720092278397;66.04153391667357;89.73875974274087;103.4229682898129;99.83123972315154;94.93311697480885;6.088961098117762;1.1608276477574355;6.301751213548276;10.481504701111374;2.860008878327165;2.346036149959951;HELO_2736;CstA family protein;COG1966;Carbon starvation protein CstA (peptide/pyruvate transporter);CstA;HELO_RS09565;CE;;;;HELO_2736;CstA family protein;0.5911882465707858;-0.08030999209609213;0.07184184892596246;0.07421447245600543;-0.5169737741147804
HELO_2738;113.5098401507861;42.18704159030487;114.41787445943969;105.857070947858;148.06095404271935;96.14749867310002;7.598010289209071;2.001723005458823;14.674608303587528;11.868220601603124;26.93397744880106;14.072694471330854;HELO_2738;probable glutathione S-transferase;COG0625;Glutathione S-transferase;GstA;HELO_RS09570;O;;;2.5.1.18;HELO_2738;probable glutathione S-transferase;1.4068011812884142;0.2486179123432697;0.6176536432700654;0.2372228231796063;-1.169578358108808
HELO_2739;31.25375223692259;17.71294592518151;51.663445849141006;60.33458146525046;105.21928675786758;48.379348492093776;7.073412398949564;2.001398033776639;4.840212200532956;7.56383700146081;10.777833593794712;5.382966384825529;HELO_2739;response regulator domain protein;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS09575;KT;;;;HELO_2739;response regulator domain protein;0.7854303102941396;0.092894120415278;1.1050660402609358;-0.6144407957046694;-1.399871105998809
HELO_2740;32.4747606913337;16.506606122651963;61.15516585099467;49.9563850742936;142.1439414963686;60.954387163892484;4.433668784019501;0.9565287942124172;2.645887177513167;3.9593234660924788;4.725937999752224;0.923882691812301;HELO_2740;sensor box / exonuclease domain protein;COG2176;DNA polymerase III, alpha subunit (gram-positive type);PolC;HELO_RS09580;L;;;2.7.7.7;HELO_2740;sensor box / exonuclease domain protein;0.9351743156926497;0.004667854518154435;1.2081882578263414;-0.8881327054018282;-1.823307021094478
HELO_2741;5.479620494492035;4.00815425301307;8.324337164198603;8.932765928262754;22.633365026418215;7.4650370842822396;0.1964554670034381;0.3865489860567495;0.8788458765373597;0.9107542473599289;0.8761270789782843;1.1282341837063925;HELO_2741;SSS family transport domain protein / histidine kinase domain protein;COG2205;K+-sensing histidine kinase KdpD;KdpD;HELO_RS09590;T;;;;HELO_2741;SSS family transport domain protein / histidine kinase domain protein;0.3716303197429123;0.139484784265961;1.4812367679280651;-0.3856070701621581;-0.7572373899050704
HELO_2742;644.4834474135192;667.9953716942074;630.8616891219892;431.25578409304325;605.5942213907275;628.3935701684466;14.743452117381574;48.59855226763445;34.2548570529417;21.897482218423324;13.547460582856539;4.497273521112322;HELO_2742;HlyU domain protein;COG5453;Uncharacterized conserved protein;;HELO_RS09595;S;;;;HELO_2742;HlyU domain protein;-0.05161612995251552;0.005646355079202081;-0.053230685804702915;0.036417659701250216;0.08803378965376574
HELO_2743;556.8632380093683;485.40548842968116;870.5911516667917;770.3816041898144;910.5902454978168;842.3245591075414;22.751544491136105;17.3533772787182;41.73756157708974;53.36897604636515;42.79919318406516;52.55053170553901;argG;argininosuccinate synthase;COG0137;Argininosuccinate synthase;ArgG;HELO_RS09600;E;argG; argininosuccinate synthase;6.3.4.5;argG;argininosuccinate synthase;0.1977519762696609;0.047563581497026775;0.11229751818817135;-0.596176484880603;-0.7939284611502639
HELO_2744;116.9587389266809;122.32528853163285;176.3408905741145;229.04161675965324;171.86346798710198;183.94163066442127;7.578239773038749;7.942583728160283;10.827546205362353;14.389364415640214;12.81990193594052;17.803925625289693;rnt;ribonuclease T;COG0847;DNA polymerase III, epsilon subunit or related 3'-5' exonuclease;DnaQ;HELO_RS09605;L;rnt; ribonuclease T;3.1.13.-;rnt;ribonuclease T;-0.06418635863300359;-0.06054478870376112;-0.09743700434741065;-0.6487877102887767;-0.5846013516557731
HELO_2745;344.21539827506194;428.0680353627292;434.01020102022034;352.0361076948828;299.7073196964159;365.6191041652125;35.69073067410412;46.35211854761111;11.938285837796748;17.854609009523408;17.573093173582667;44.34605387603801;grxD;glutaredoxin;COG0278;Glutaredoxin-related protein;GrxD;HELO_RS09610;O;grxD; glutaredoxin;;grxD;glutaredoxin;-0.3137096103176553;0.2467672673865362;-0.28592197943232023;-0.08678514815011518;0.22692446216754014
HELO_2746;349.79444240231436;269.8664636150409;377.8531107805163;274.67192026703725;385.73438688158916;384.8403966655719;14.373780832339598;6.911414820235851;20.915946567076805;9.7933125872624;17.932849190685253;42.407938619327545;argF;ornithine carbamoyltransferase;COG0078;Ornithine carbamoyltransferase;ArgF;HELO_RS09615;E;argF; ornithine carbamoyltransferase;2.1.3.3;argF;ornithine carbamoyltransferase;0.3730441091550638;-0.026365604408814747;0.0033388504372258154;-0.13737830687945518;-0.510422416034519
HELO_2747;3.7466434835664857;4.778234703226034;2.939410960105316;3.6415804525347286;4.02787345630061;2.6832595065710545;0.5786431170232338;0.24743527453589548;0.23826264543930206;0.9504389655895886;0.48442655307123317;0.4243258870069853;HELO_2747;Kce family protein;COG3246;Uncharacterized conserved protein, DUF849 family;;HELO_RS09620;S;;argF;;HELO_2747;Kce family protein;-0.28372111098596076;0.0969968801397516;0.4489652929552226;0.3659246473294364;0.6496457583153972
HELO_2748;3.578275166843293;2.3605850129944117;2.8342603632325827;3.895315155391996;4.651560600554511;3.1532584392641265;0.8313513518342491;0.23951868636108617;0.42787951047694833;0.9583796938739517;0.3344041211713867;0.5148090846476477;lcdH;L-carnitine dehydrogenase;COG1250;3-hydroxyacyl-CoA dehydrogenase;FadB;HELO_RS09625;I;lcdH; L-carnitine dehydrogenase;1.1.1.108;lcdH;L-carnitine dehydrogenase;0.4460917751819795;-0.11529534150798249;0.44440565567716206;0.140560528199432;-0.3055312469825475
HELO_2749;3.6179772734928264;2.2925960834551593;2.3350456483852984;3.0547373187590456;4.116554969924326;2.7429725735540695;0.8095635333539696;0.4259005138911282;0.5896637922539391;0.5298756499484603;0.26831706301816;0.20925186468867746;HELO_2749;thioesterase domain protein;COG0824;Acyl-CoA thioesterase FadM;FadM;HELO_RS09630;I;;lcdH;3.1.2.-;HELO_2749;thioesterase domain protein;0.4880355318291145;-0.16647796858935582;0.4509882784105812;0.30307659617678717;-0.18495893565232735
HELO_2750;1.7442169026294947;1.6982227285430476;2.0182009445571296;1.7216954668169944;3.4429548079224586;2.2164662224961975;0.04803759429628078;0.09718004547579015;0.40854793320891025;0.44366091443933503;0.3292533524959051;0.18480961745377947;HELO_2750;BCC family transport protein;COG1292;Choline-glycine betaine transporter;BetT;HELO_RS09635;M;;;;HELO_2750;BCC family transport protein;0.024385074021421538;-0.09178767817223776;0.46604292846810136;-0.2290820219099492;-0.25346709593137073
HELO_2751;3.7255217841118036;2.47005388467135;2.7383547275286158;2.6783392073823222;3.74259371472138;2.612443985874108;0.442446121472288;0.42091525039666605;0.2964436480921637;0.7155914820407583;0.023272311436080384;0.1906272521364748;HELO_2751;alpha/beta hydrolase fold protein;COG0657;Acetyl esterase/lipase;Aes;HELO_RS09640;I;;;3.1.1.-;HELO_2751;alpha/beta hydrolase fold protein;0.4455155722297899;0.049428253470568784;0.3927010643683946;0.38749842054270567;-0.05801715168708421
HELO_2752;16.685700975229274;10.828857369566393;72.24546121663042;65.07261744118098;78.65140025883075;69.67708453539984;1.935150056029519;1.5659226117872018;19.523336445928194;3.2807817455588766;2.9878630807238675;37.64114511277274;HELO_2752;glutamate/glycine-rich protein;;;;;;;;;HELO_2752;glutamate/glycine-rich protein;0.5802726809887719;0.05149683394320981;0.1724571950858902;-1.9986591276432817;-2.5789318086320536
HELO_2753;31.7204168456144;13.180228004816863;26.456720247277403;32.39166444387819;26.732032722361296;29.174897062509135;2.366719179713566;0.39674060615468343;9.970955080797962;4.248162376817795;1.9451602947370976;10.592510407661205;ybiX;PKHD-type hydroxylase;COG3128;Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX;PiuC;HELO_RS09650;R;ybiX; PKHD-type hydroxylase;1.14.11.-;ybiX;PKHD-type hydroxylase;1.2063103978283936;-0.1361895460749718;-0.12179548148823649;0.11684227834662497;-1.0894681194817686
HELO_2754;57.21863521722963;44.1958533293896;57.21397836886348;75.44364417591427;67.28662013068318;56.40154168600497;3.9661715919852387;2.8427546132564543;1.4757307240959414;3.536090747712487;4.937471294761827;3.4389000136871553;cdhR;PfpI/HTH domain protein CdhR (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS09655;K;cdhR; PfpI/HTH domain protein CdhR (homolog to transcription regulator CdhR);;cdhR;PfpI/HTH domain protein CdhR (homolog to transcription regulator CdhR);0.36529060666229807;0.020276130158983996;0.250513443788293;0.020391534457499638;-0.34489907220479843
HELO_2755;216.68301356637735;167.77729506611857;120.82100151425107;131.78154569977025;117.61341063169152;121.73692461109844;12.800582936018076;8.891356556883514;6.468537260638327;1.7627489291821232;3.1916423807945553;4.770695180974994;HELO_2755;ABC-type transport system periplasmic substrate-binding protein;COG2113;ABC-type proline/glycine betaine transport system, periplasmic component;ProX;HELO_RS09660;E;;cdhR;;HELO_2755;ABC-type transport system periplasmic substrate-binding protein;0.3671079971520097;-0.010806469525762807;-0.04930220715328204;0.8266594944751633;0.4595514973231536
HELO_2756;29.463876708450897;19.262498949143986;19.308623465816773;19.320534634194487;20.19980908301399;18.40677438365789;1.3209504161422496;0.4653691024752949;1.170248636050324;1.8775821292270185;1.9502783627490847;0.769033573628216;HELO_2756;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS09665;K;;;;HELO_2756;PfpI/HTH domain protein (homolog to transcription regulator CdhR);0.5882874340610744;0.06553210954633837;0.12749092609598822;0.6505391985651539;0.06225176450407943
HELO_2757;5.590308535023353;4.025294041307949;3.503755921136761;3.818547606185948;4.3762326257762405;4.243743694301237;0.9562602781475492;0.5457352782769017;1.2261919097762934;0.4250599704654686;0.29593924762138357;0.5837192134602319;HELO_2757;gamma-butyrobetaine dioxygenase;COG2175;Taurine dioxygenase, alpha-ketoglutarate-dependent;TauD;HELO_RS09670;Q;;;1.14.11.1;HELO_2757;gamma-butyrobetaine dioxygenase;0.39113799460496956;-0.21946852730590694;0.03599839317336162;0.3297488380265676;-0.06138915657840194
HELO_2758;48.39512126518645;21.346315786985787;34.92833380675218;41.01176232629622;31.11066181518088;33.45132387456034;3.212018190442192;1.258582653354548;0.5803007067618287;1.9921972113949455;1.2576385418156202;0.7793805070043368;HELO_2758;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS09675;K;;;;HELO_2758;PfpI/HTH domain protein (homolog to transcription regulator CdhR);1.144331559043378;0.06056260823157;-0.10150702304031878;0.5198091314758404;-0.6245224275675376
HELO_2759;14.504947534865588;9.093032473641852;15.219061621984103;19.656749502541036;15.431119172996484;15.245012886571962;0.8597778545530851;0.24314028133261834;1.1704084771902747;1.5589068687887984;1.5234367390008714;1.7384102634202783;HELO_2759;probable dioxygenase (homolog to gamma-butyrobetaine dioxygenase);COG2175;Taurine dioxygenase, alpha-ketoglutarate-dependent;TauD;HELO_RS09680;Q;;;1.14.11.1;HELO_2759;probable dioxygenase (homolog to gamma-butyrobetaine dioxygenase);0.619368943765314;-0.002306535409823063;0.016433861832712893;-0.06726824389033315;-0.6866371876556472
HELO_2760;7.915743179522373;4.721974968428758;4.882842775314068;6.280112547289387;7.133681010621127;5.566724773254271;0.34899777037025836;0.7853384801443807;0.499484778777499;0.13688634589615703;1.3172198513052413;0.73069276392268;HELO_2760;HD family hydrolase;COG4341;Predicted HD phosphohydrolase;;HELO_RS09685;R;;;;HELO_2760;HD family hydrolase;0.6398418735559326;-0.15866051045378882;0.3087344220262773;0.44118107016746544;-0.19866080338846714
HELO_2761;12.637401914981917;8.331276724815146;13.867004742107696;24.351315792993883;19.25617021932449;15.079572599331811;1.3206399419624055;0.8190444828504017;1.3194742077882389;0.20763526701516663;2.195450174088615;2.065485349379572;aruI1;2-ketoarginine decarboxylase;COG0028;Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme;IlvB;HELO_RS09690;EH;aruI1; 2-ketoarginine decarboxylase;2.2.1.6;aruI1;2-ketoarginine decarboxylase;0.547422427962887;-0.1131150430285639;0.3331323736880245;-0.23766023947410053;-0.7850826674369875
HELO_2762;11.06131764070276;10.970909245054893;15.38831422196967;21.407395038557627;22.18865714950834;16.357021031148175;1.634837918864043;0.8380576721252305;0.4863057024415074;0.9387473373200075;1.4943838109468162;2.8801713214331546;HELO_2762;ABC-type transport system periplasmic substrate-binding protein;COG2113;ABC-type proline/glycine betaine transport system, periplasmic component;ProX;HELO_RS09695;E;;aruI1;;HELO_2762;ABC-type transport system periplasmic substrate-binding protein;0.010854787613958639;-0.08285190089929362;0.4178999155581069;-0.52513183735054;-0.5359866249644987
HELO_2763;14.668351831195364;13.611276343285454;14.50547467087757;14.705621094654413;20.17488027798939;15.643000172421429;1.320668503681922;0.33575291019123793;1.828307391613703;1.4241928659756962;0.9218035647488863;2.054239901012628;HELO_2763;aldolase domain protein;COG0235;5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation);AraD;HELO_RS09700;GE;;;;HELO_2763;aldolase domain protein;0.10077122150407147;-0.10213783423528922;0.347438286383821;-0.08706209692020295;-0.18783331842427442
HELO_2764;14.686040776640757;11.237862304129536;21.766817652137522;24.86045579727004;30.119304600388734;23.105265474840277;1.7202195066624448;0.9555507721033792;0.6014236249502118;0.44163269200611305;1.1916918111248953;3.996336477277272;aruH;arginine--pyruvate aminotransferase;COG0436;Aspartate/methionine/tyrosine aminotransferase;AspB;HELO_RS09705;E;aruH; arginine--pyruvate aminotransferase;2.6.1.84;aruH;arginine--pyruvate aminotransferase;0.35812968418475455;-0.08241567291277452;0.36846150343246187;-0.6198670625408016;-0.9779967467255561
HELO_2765;13.89659134618156;10.879087341970534;20.40318805024903;25.049909293890703;34.91305580911028;23.546571054410034;1.5633249891120233;1.6171347624498253;3.3315758117324115;2.0275106095030906;2.1701747371541704;0.3322261714884839;HELO_2765;ABC-type transport system ATP-binding protein;COG1126;ABC-type polar amino acid transport system, ATPase component;GlnQ;HELO_RS09710;E;;aruH;7.4.2.1;HELO_2765;ABC-type transport system ATP-binding protein;0.3265582498183943;-0.1976958013646355;0.5489869093457793;-0.7205392570401834;-1.0470975068585777
HELO_2766;10.653896293571963;16.314118939537284;27.802684271056478;29.40876835754936;38.2872172070748;23.351934409146278;1.6757062123443753;1.6866677141429172;4.059000110717709;3.7162637827606257;3.5663114989392595;2.6018369876566276;HELO_2766;ABC-type transport system periplasmic substrate-binding protein;COG0834;ABC-type amino acid transport/signal transduction system, periplasmic component/domain;HisJ;HELO_RS09715;TE;;;;HELO_2766;ABC-type transport system periplasmic substrate-binding protein;-0.5711365977301028;0.24216689201837305;0.690023604288343;-1.0632240006150253;-0.4920874028849225
HELO_2767;3.357964481730104;6.264183448984891;10.205191911234715;10.891694378704479;19.95194634793728;12.54382507272814;0.6192874040182302;1.095687703845315;1.2330638496134998;1.0656689373162433;1.350610340699845;1.5278770731576923;HELO_2767;ABC-type transport system permease protein;COG4215;ABC-type arginine transport system, permease component;ArtQ;HELO_RS09720;E;;;;HELO_2767;ABC-type transport system permease protein;-0.737146198516982;-0.2734678870391236;0.6294490253424261;-1.6359089017604753;-0.8987627032434933
HELO_2768;7.164170286753567;9.508482078119778;20.159010519848405;19.444273013961684;31.58411272184483;21.605585148240433;0.4221290636675761;0.9280390300610475;2.326650360411566;1.20289270088794;0.7428295870586954;3.2417196200699547;HELO_2768;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS09730;I;;;1.2.1.8;HELO_2768;aldehyde dehydrogenase;-0.36417611168049246;-0.09540709964572347;0.5274894478663015;-1.4693010832083178;-1.1051249715278253
HELO_2769;14.09329147853515;5.28315616899718;14.007286953634534;14.755585917105748;15.565277261763612;14.187392924715951;0.7668194100399053;1.495547508991603;1.7926465173092418;1.9356544935419768;0.3996775310704774;1.0567814446416701;HELO_2769;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS09740;GER;;;;HELO_2769;DMT superfamily transport protein;1.2643461126638758;-0.017211050028004493;0.12528811340849044;-0.008966780603084867;-1.2733128932669606
HELO_2770;1.1481369744770855;1.6820936055261129;1.1590619009380045;1.2263649472779192;1.8529173122145217;1.4243063451759383;0.14017771269152474;0.09263260954049485;0.20673682051361786;0.06837030935582483;0.0329611839338532;0.5375662528696209;gspD1;general secretion pathway protein GspD;COG1450;Type II secretory pathway component GspD/PulD (secretin);PulD;HELO_RS09745;U;gspD1; general secretion pathway protein GspD;;gspD1;general secretion pathway protein GspD;-0.3202735997113664;-0.16716740867973057;0.23486591792103306;-0.17448602640946564;0.14578757330190073
HELO_2771;1.0612302766747705;1.0499526979607605;0.4840022133112976;0.6088797566004964;1.180964631308805;0.4627595683026031;0.5658018278859869;0.25982906099577796;0.4540674228964654;0.5226376342800594;0.5312402227887091;0.06953178592256902;gspN;general secretion pathway protein GspN;;;;;;;;;gspN;general secretion pathway protein GspN;0.007915068628453481;0.020800588420945454;0.5762737187477852;0.49481303374780017;0.4868979651193467
HELO_2772;0.8871954596663105;2.5806397343821397;0.49818319710703873;0.8735707297080606;1.3364029144498033;0.5360462762890006;0.2723371930832504;0.48805016525689504;0.22640522091518217;0.31845225087883655;0.8631950827301959;0.19762567403274547;gspM;general secretion pathway protein GspM;;;;;;;;;gspM;general secretion pathway protein GspM;-0.9239735166121785;-0.0360076339950719;0.6050674089028696;0.29702217214670346;1.220995688758882
HELO_2773;1.0450405300970484;2.4606273130409417;1.0466426090732759;1.008077117736413;1.7649824691262896;1.0733891786051073;0.014440510406164486;0.20916733410742666;0.5462420019789983;0.6908506523803535;0.23344869556722472;0.2249465931141286;gspL;general secretion pathway protein GspL;COG4972;Type IV pilus assembly protein, ATPase PilM;PilM;HELO_RS09760;NW;gspL; general secretion pathway protein GspL;;gspL;general secretion pathway protein GspL;-0.7589041452082432;-0.018731741548585257;0.4152793952116547;-0.019861502301612877;0.7390426429066304
HELO_2774;1.4262751959213211;3.4805204252279363;0.8708043883919799;1.683133968295641;1.4616282416389959;1.203375241833869;0.22774689383065025;0.8669106651616981;0.5350931518963616;0.4707282922734274;0.5469470984606473;0.3634244586057523;gspK1;general secretion pathway protein GspK;COG3156;Type II secretory pathway, component PulK;PulK;HELO_RS09765;U;gspK1; general secretion pathway protein GspK;;gspK1;general secretion pathway protein GspK;-0.8849231203180494;-0.23605649349234104;0.1598976890236845;0.1390279833107455;1.023951103628795
HELO_2775;1.8240482152496515;3.768272356284752;0.6477948172313344;0.9013087043885575;1.3115170804698528;0.8350937480945541;0.36286551426918656;0.48376570467554003;0.3210079809545136;0.08419874293114063;0.2653192413951894;0.1844610073813814;gspJ1;general secretion pathway protein GspJ;COG4795;Type II secretory pathway, PulJ/GspJ component;PulJ;HELO_RS09770;U;gspJ1; general secretion pathway protein GspJ;;gspJ1;general secretion pathway protein GspJ;-0.7557019225535875;-0.15531715697903847;0.3329862562457494;0.6219109532326027;1.3776128757861903
HELO_2776;2.235813247495708;5.297594437920965;0.6053596982697237;0.3828491317675493;1.3844649786255274;0.84030780629619;0.35858046782024106;0.15816591686578663;0.28464707333589684;0.40852930712084634;0.6207602189781499;0.747589951166936;gspH1;general secretion pathway protein GspH;;;;;;;;;gspH1;general secretion pathway protein GspH;-0.9606725054702376;-0.1970505037703878;0.3737185047551228;0.8141812572972882;1.7748537627675258
HELO_2777;2.347721719555175;7.764769297647368;2.2483283655598645;2.9136834517054155;5.126907042830013;2.905900381711525;0.2460651185800491;1.1760484106180633;0.5343241776746975;1.307636273414281;1.1856775423197632;0.9192200810773293;gspG1;general secretion pathway protein GspG;COG2165;Type II secretory pathway, pseudopilin PulG;PulG;HELO_RS09785;NWU;gspG1; general secretion pathway protein GspG;;gspG1;general secretion pathway protein GspG;-1.3885365091254402;-0.2659576759815201;0.6495038085891103;-0.22247554600209596;1.1660609631233443
HELO_2778;1.468149619287308;4.766901236349853;1.1989149720188303;1.4698465288167528;1.8838321868458399;1.2022456771924437;0.21146861442911064;0.2384248308010788;0.10366188413047753;0.32351225273843637;0.2752879969939156;0.21053746263889933;gspF1;general secretion pathway protein GspF;COG1459;Type II secretory pathway, component PulF;PulF;HELO_RS09790;NWU;gspF1; general secretion pathway protein GspF;;gspF1;general secretion pathway protein GspF;-1.2243664617413281;-0.0021836025253161306;0.38901179367265093;0.1644544319013781;1.3888208936427062
HELO_2779;2.5168749019340613;11.08365861028269;2.892246854449212;2.996362115564876;4.479393764510271;2.4576268130114713;0.37154807687653935;0.8461802967018572;0.27747279486317367;0.29263568774496607;0.2654210726951651;0.09717095551251669;gspE1;general secretion pathway protein GspE;COG2804;Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB;PulE;HELO_RS09795;NWU;gspE1; general secretion pathway protein GspE;7.4.2.8;gspE1;general secretion pathway protein GspE;-1.78069140730519;0.17082104667796516;0.6642341183721541;0.0245118529697137;1.8052032602749037
HELO_2780;5.735878390862999;14.81996147028773;8.452415357709556;3.6916594971757832;13.913624627297045;8.479250985278393;0.6403621699653455;1.9582079095439275;0.652798575231299;0.4876595939148895;1.105157140249089;1.0867890064178585;HELO_2780;glycoside hydrolase domain protein;COG1472;Periplasmic beta-glucosidase and related glycosidases;BglX;HELO_RS09805;G;;;3.2.1.21;HELO_2780;glycoside hydrolase domain protein;-1.2318080886894038;-0.004090041736613426;0.6537859623623286;-0.4929069749856918;0.738901113703712
HELO_2781;29.621657123881203;26.84166211947877;33.533723179392105;45.84091795261656;29.01055068832954;34.480135321739745;2.0835578952037657;2.068468583759188;2.101478457259756;3.839846935277647;1.8996001782504228;3.2994512962503695;HELO_2781;MATE family transport protein;COG0534;Na+-driven multidrug efflux pump, DinF/NorM/MATE family;NorM;HELO_RS09815;V;;;;HELO_2781;MATE family transport protein;0.13730701672911927;-0.039005628456739494;-0.24154171972935323;-0.21245915416610206;-0.34976617089522133
HELO_2782;84.86750534881935;40.94980057649943;77.72103087559312;89.84359211749313;84.75623641230986;70.19920882772787;7.797065316055075;2.5770418509535387;9.960358133120604;7.857600829611128;8.505110824163824;4.080498664951682;HELO_2782;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS09825;K;;;;HELO_2782;AraC family transcription regulator;1.0334483264186547;0.1448879034082191;0.268380381646363;0.27025106881063987;-0.7631972576080148
HELO_2783;100.40979741669476;42.455979853639114;119.62101673311433;114.55355889977335;143.41236127601533;133.17582310223952;1.5033375762426857;1.3651502511258902;9.14126302048411;10.840571503111367;9.439868543560907;6.304713194634998;HELO_2783;Spo0M family protein;COG4326;Stage 0 sporulation-control protein Spo0M;Spo0M;HELO_RS09830;D;;;;HELO_2783;Spo0M family protein;1.2225704199487861;-0.15364343729750018;0.10606949963130496;-0.4039276974400279;-1.626498117388814
HELO_2784;36.212203773997196;31.930055388323524;65.94627923103013;69.2541592146914;75.3930590075421;60.61674291003442;3.554505344859407;2.735221649193846;4.79019478085716;4.214342119856182;5.522687098147827;2.587339524075414;HELO_2784;gluconolactonase family protein;COG3386;Sugar lactone lactonase YvrE;YvrE;HELO_RS09835;G;;;;HELO_2784;gluconolactonase family protein;0.1763708934557533;0.11968145219960213;0.3101191396162708;-0.7275465908526346;-0.9039174843083879
HELO_2785;10.684043096826011;10.366154982227714;26.643339540980005;32.87724510876201;36.9998320879995;24.334302502085986;0.9000314579170029;1.9532314279064098;1.8120905053181744;2.07398331709568;3.464459461911961;1.7312776042499298;araH;ABC-type transport system permease protein (probable substrate L-arabinose);COG1172;Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component;AraH;HELO_RS09840;G;araH; ABC-type transport system permease protein (probable substrate L-arabinose);;araH;ABC-type transport system permease protein (probable substrate L-arabinose);0.039795292318955955;0.12583980611294177;0.5849009341775186;-1.1165525247758943;-1.1563478170948502
HELO_2786;9.167175484748432;8.145115557549332;28.089383610211353;40.389362721078975;42.19801986070781;28.46721219873646;0.632687773315211;0.5769515128573063;0.6289826294653315;2.431771590663666;1.4051998781416424;3.9129882548606747;araG;ABC-type transport system ATP-binding protein (probable substrate L-arabinose);COG1129;ABC-type sugar transport system, ATPase component;MglA;HELO_RS09845;G;araG; ABC-type transport system ATP-binding protein (probable substrate L-arabinose);7.5.2.12;araG;ABC-type transport system ATP-binding protein (probable substrate L-arabinose);0.15284563861191236;-0.01861785126788451;0.5518546046698836;-1.5351916343411869;-1.6880372729530992
HELO_2787;7.329741237926079;5.640406803806688;39.361570249083634;54.276118886809435;44.039068248833985;39.55176635318087;0.8435416356890423;0.5747634538908698;2.8412769611920874;3.0733636479761697;3.421977535461005;7.555600612391194;araF;ABC-type transport system periplasmic substrate-binding protein (probable substrate L-arabinose);COG1879;ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain;RbsB;HELO_RS09850;G;araF; ABC-type transport system periplasmic substrate-binding protein (probable substrate L-arabinose);;araF;ABC-type transport system periplasmic substrate-binding protein (probable substrate L-arabinose);0.32700005270672694;-0.0067824537482072955;0.15141222510051122;-2.283421172388588;-2.610421225095315
HELO_2788;14.144306853526109;5.349757311305171;20.75390228609268;17.550903944438776;26.34467537994155;16.72477726752645;0.6027234222967003;0.44122237248718826;2.1174307003306216;1.2728363581163986;1.4152137003444711;0.6898823870025572;HELO_2788;ABC-type transport system permease protein;COG0395;ABC-type glycerol-3-phosphate transport system, permease component;UgpE;HELO_RS09855;G;;araF;;HELO_2788;ABC-type transport system permease protein;1.2540021902711724;0.2955067210927229;0.6254924369297283;-0.22699195013756945;-1.4809941404087419
HELO_2789;4.824803446387676;2.0828924407934704;7.591370651366809;9.462547199572569;13.853399618385568;8.642240790299999;0.22861535126038438;0.39895892416336654;1.0564678208182774;1.7741560361218636;0.42147785285145745;0.4505163092270347;HELO_2789;ABC-type transport system permease protein;COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS09860;G;;;;HELO_2789;ABC-type transport system permease protein;0.9179248118736856;-0.16648014318101012;0.623352807253319;-0.7271590898734557;-1.6450839017471413
HELO_2790;11.019882699586718;5.576217920814933;22.394379549905256;24.61761416795476;42.85327970368627;18.660944633913996;1.3195054683490355;0.2549496039954868;1.280707294783205;3.3682146088349043;0.42736137785733713;2.068886046045333;HELO_2790;ABC-type transport system periplasmic substrate-binding protein;COG1653;ABC-type glycerol-3-phosphate transport system, periplasmic component;UgpB;HELO_RS09865;G;;;;HELO_2790;ABC-type transport system periplasmic substrate-binding protein;0.8700928045145608;0.2508293276366782;1.1573521037575496;-0.7099098223239473;-1.5800026268385081
HELO_2791;5.989598346199194;2.483998040271928;5.710188211535222;6.146183427702532;9.507748874968218;5.354399408516499;0.421652291190365;0.6396907035402949;0.5787276830065584;0.8316525749508356;1.8971331688343844;0.32526903553689906;HELO_2791;ABC-type transport system ATP-binding protein;COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS09870;G;;;;HELO_2791;ABC-type transport system ATP-binding protein;1.004465741798287;0.07859745848068744;0.7256259477471967;0.13745378010726528;-0.8670119616910217
HELO_2792;8.830982867918301;2.770035748098413;7.494165091641528;7.018954090273574;10.400264247869718;6.98162190615822;0.39390470483810114;0.886772718238912;1.0368487234024553;1.954973622336623;0.9776694028067805;1.2480977435118246;abfA;alpha-L-arabinofuranosidase;COG3534;Alpha-L-arabinofuranosidase;AbfA;HELO_RS09875;G;abfA; alpha-L-arabinofuranosidase;3.2.1.55;abfA;alpha-L-arabinofuranosidase;1.3827574560437619;0.08979020981083474;0.5143134208319258;0.30065372026774995;-1.082103735776012
HELO_2793;4.715113279431713;4.122487083634364;13.025066772629115;8.953953022720057;13.858271355965721;12.844745434829226;0.8186148153573001;0.45039826930082155;1.0043955994013904;0.9043635187902673;0.8362412010566221;2.2041348337318385;HELO_2793;outer membrane porin;;;;;;;;;HELO_2793;outer membrane porin;0.15793765294333717;0.01866911252445158;0.10192775239544982;-1.2764845273861662;-1.4344221803295034
HELO_2794;13.12488201011527;9.231446193152433;19.338007987174745;24.998848991258495;29.969299508662512;20.462041754106796;0.3629292670760254;1.0153883547493168;2.0912756624835067;1.3135852014979612;0.9621298839705239;3.3056938583612974;galM;aldose 1-epimerase;COG2017;Galactose mutarotase or related enzyme;GalM;HELO_RS09885;G;galM; aldose 1-epimerase;5.1.3.3;galM;aldose 1-epimerase;0.46522873489048644;-0.07760895003424384;0.5290514203007994;-0.6035485146511999;-1.0687772495416863
HELO_2795;50.41116910194771;28.596634034699303;90.22670050518327;81.81873275054174;102.09190698594851;90.1513110719341;1.651212393978076;0.6151348072304701;15.261480987425111;2.8328238932503536;9.408098322021756;9.222823448729267;HELO_2795;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS09890;K;;galM;;HELO_2795;LysR family transcription regulator;0.79664870928646;0.0011927311493140635;0.17759576891757245;-0.8261815876889136;-1.6228302969753736
HELO_2796;55.08813230322186;30.851594957659916;47.53821449685123;56.0937827635528;70.94642602396372;48.170762838527004;2.1437591871152875;0.805968619683713;4.228564153779623;1.9834758112484387;3.7878675376133306;5.262852214829779;araA;L-arabinose 1-dehydrogenase;COG0673;Predicted dehydrogenase;MviM;HELO_RS09895;R;araA; L-arabinose 1-dehydrogenase;1.1.1.48;araA;L-arabinose 1-dehydrogenase;0.8163299263045722;-0.018679698213092344;0.5491222847207737;0.1898948056526253;-0.626435120651947
HELO_2797;47.32416822177171;9.32327838386721;20.198846981425067;24.624238475014995;32.38898100781566;19.728731308824536;0.7272470275322361;0.24296475099053663;0.6460760725617252;1.3812909376203806;1.9188029110229654;0.967870912568376;xylD;D-xylonate dehydratase;COG0129;Dihydroxyacid dehydratase/phosphogluconate dehydratase;IlvD;HELO_RS09900;GE;xylD; D-xylonate dehydratase;4.2.1.9;xylD;D-xylonate dehydratase;2.226843697273045;0.03235397808206475;0.6877402449749077;1.2211130805543693;-1.005730616718676
HELO_2798;8.574097096648222;1.333623562489004;7.799332835896037;10.044436060180752;16.81446291739989;7.868136867805113;0.5718971134882618;0.3328857181264273;0.8218828166307168;0.5321693614388244;0.394301188254184;2.210916575776693;HELO_2798;glycoside hydrolase domain protein;COG3940;Beta-xylosidase, GH43 family;;HELO_RS09910;G;;xylD;;HELO_2798;glycoside hydrolase domain protein;2.036564579118391;-0.011236893467564624;1.0063460472172663;0.11050540092453742;-1.9260591781938534
HELO_2799;42.367820588439116;10.150875474084755;10.542798939829483;13.589219975801834;20.857410671404185;10.622975841419361;4.412925240689846;0.858037562883792;0.8157384949826832;1.2978075433024057;1.9390548546994255;1.1668511600705254;arbA;alpha-L-arabinofuranosidase;COG3507;Beta-xylosidase;XynB2;HELO_RS09915;G;arbA; alpha-L-arabinofuranosidase;3.2.1.99;arbA;alpha-L-arabinofuranosidase;1.959467960637399;-0.009986394262229137;0.9111430122929782;1.8996454530540197;-0.05982250758337937
HELO_2800;91.13535470535044;14.476614960308845;24.18117829139639;29.084551576198994;52.95234788662509;25.98172876645955;10.55180065874634;1.5252536338566474;0.07171268052729214;0.6747158328356834;1.1432328312472144;2.737466701103603;araC;L-arabonate dehydratase;COG0129;Dihydroxyacid dehydratase/phosphogluconate dehydratase;IlvD;HELO_RS09920;GE;araC; L-arabonate dehydratase;4.2.1.25;araC;L-arabonate dehydratase;2.5736649015109236;-0.09963699522935254;0.9997029567335627;1.771772074515554;-0.8018928269953696
HELO_2801;45.76429150783167;2.470795062140994;12.13504103181855;15.758562926642554;29.15698458429577;12.113196786122877;6.160586427076527;0.11819557506314535;1.3001721316446546;1.0092142584271242;0.3618826762152605;2.977942175675357;HELO_2801;TRAP transporter substrate-binding protein;COG4663;TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component;FcbT1;HELO_RS09925;Q;;araC;;HELO_2801;TRAP transporter substrate-binding protein;3.752069243604259;0.0024012729868738703;1.2014727455950545;1.834387896243261;-1.9176813473609984
HELO_2802;6.709563244067396;0.6792236026715707;1.5623121496120718;1.36397024194168;2.804101500395275;0.8497372521035272;1.3200581721295748;0.02576778691314615;0.9447619464374184;0.6139268785203373;0.7210348529433781;0.7813641723446332;HELO_2802;TRAP transporter small transmembrane protein;COG4665;TRAP-type mannitol/chloroaromatic compound transport system, small permease component;FcbT2;HELO_RS09930;Q;;;;HELO_2802;TRAP transporter small transmembrane protein;2.1988547820832243;0.4701258842776822;1.0402353843155323;2.059328775921833;-0.13952600616139166
HELO_2803;2.9961987373695123;0.7286323832315028;1.2683329289972611;1.8257520646090857;2.2230028536115416;1.269537420315855;0.570417918326221;0.21036900547845752;0.33054011490773466;0.1509638563438087;0.23720075712075023;0.24158358770520802;HELO_2803;TRAP transporter large transmembrane protein;COG4664;TRAP-type mannitol/chloroaromatic compound transport system, large permease component;FcbT3;HELO_RS09935;Q;;;;HELO_2803;TRAP transporter large transmembrane protein;1.208997239225507;-0.0007658718998884151;0.5060071900004717;0.8162300567076255;-0.3927671825178817
HELO_2804;16.178670860092723;5.746035054617887;12.278258838094189;14.844968944499746;19.967179126984714;13.46242254276463;0.30314616578279163;0.17031809364872463;1.1002701512095288;1.4828527888434577;0.9172552825898483;2.6060788038060707;HELO_2804;major facilitator superfamily transport protein;COG2211;Na+/melibiose symporter or related transporter;MelB;HELO_RS09940;G;;;;HELO_2804;major facilitator superfamily transport protein;1.3485066970772617;-0.12324325238400169;0.5358235451986118;0.24830918465562357;-1.100197512421638
HELO_2805;20.96804119751641;5.658610282755184;14.545594499065691;14.263490272130609;28.694633198281593;14.673564297344607;1.2729074510792944;0.17947892830657222;1.2503687330679527;0.24463860972800724;4.300757839311418;2.671989220545512;HELO_2805;alpha-N-arabinofuranosidase;COG3940;Beta-xylosidase, GH43 family;;HELO_RS09945;G;;;;HELO_2805;alpha-N-arabinofuranosidase;1.7221132269141304;-0.01182750814046285;0.9218689140758896;0.4870729383116368;-1.2350402886024936
HELO_2806;46.83304922753488;14.244559634255454;31.248652361372;32.3284878033002;53.25201457214194;30.17733544421849;1.4006671107401745;0.606680629857754;2.0795021815015824;1.8818140333319713;3.068340203676829;2.3663361135873338;HELO_2806;GguC domain protein;COG3802;Uncharacterized conserved protein GguC, FAA hydrolase family;GguC;HELO_RS09950;S;;;;HELO_2806;GguC domain protein;1.6497132859808765;0.048741238950579024;0.7991790769243936;0.6175101280875337;-1.0322031578933428
HELO_2807;144.1575704653309;35.26154204101114;72.89119734169657;66.51349072100231;143.29754802328895;75.69628481429254;5.507793307058715;1.1810438777850432;1.3451723693885564;1.557337392529476;9.795476774127188;8.45043830163959;HELO_2807;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS09955;I;;;1.2.1.26;HELO_2807;aldehyde dehydrogenase;2.0011076325636816;-0.05375418859215664;0.9118181849824305;0.9203912153696985;-1.0807164171939831
HELO_2808;25.557746783683797;8.183994039173248;10.368765033635777;10.023835528795752;23.5949860072749;11.033548018674665;2.372493106285626;0.873258898103724;0.6531718422145881;1.5088765782341254;1.5955966450640195;0.5328052039770553;xylX3;2-keto-3-deoxyxylonate dehydratase;COG3970;Fumarylacetoacetate (FAA) hydrolase family protein;;HELO_RS09960;R;xylX3; 2-keto-3-deoxyxylonate dehydratase;;xylX3;2-keto-3-deoxyxylonate dehydratase;1.53193913977664;-0.08198652947626028;1.0313021591538463;1.1420706754079473;-0.3898684643686927
HELO_2809;79.32150913632847;49.12186692678387;63.175467336783896;64.82945364236352;71.84985985993818;61.61834577979321;7.998767251913595;1.7950424892801486;2.4289792691169785;7.511093674241171;7.237575535439185;1.4124574417226505;HELO_2809;GntR family transcription regulator;COG2186;DNA-binding transcriptional regulator, FadR family;FadR;HELO_RS09965;K;;xylX3;;HELO_2809;GntR family transcription regulator;0.6803462230950457;0.035436500209779176;0.21834080042160853;0.35920097931784856;-0.3211452437771971
HELO_2810;100.0037894279961;104.35511657297413;122.93215857359469;122.11113945405266;90.13614178844803;131.93512848390586;4.537270666981813;5.6275702593332575;15.077091327806496;5.180113095368171;2.0248245248635763;2.7938549892823414;uvrY;response regulator/HTH domain transcription regulator UvrY;COG2197;DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains;CitB;HELO_RS09975;KT;uvrY; response regulator/HTH domain transcription regulator UvrY;;uvrY;response regulator/HTH domain transcription regulator UvrY;-0.060850959799665816;-0.10117179702618362;-0.5446271901838049;-0.39631297067628957;-0.33546201087662375
HELO_2811;75.11397959551475;75.91104014493412;85.43963792056353;95.50064653203725;93.89339656219961;84.36762101828971;4.95167899225207;0.3036538099158695;8.333200119662285;2.5118982670613184;4.987461000067317;2.701437094636949;uvrC;UvrABC system protein UvrC;COG0322;Excinuclease UvrABC, nuclease subunit;UvrC;HELO_RS09980;L;uvrC; UvrABC system protein UvrC;;uvrC;UvrABC system protein UvrC;-0.015029250815493889;0.018004053495356942;0.15261872100012575;-0.1655275225836288;-0.1504982717681349
HELO_2812;116.20836396539737;62.426256688260764;134.63955497217378;187.73637794352445;164.91313796399027;136.21018711890855;7.17357095277047;6.59913597366605;6.67796467199078;13.993471569959041;20.53506868803376;12.032456651063857;pgsA;CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;COG0558;Phosphatidylglycerophosphate synthase;PgsA;HELO_RS09985;I;pgsA; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;2.7.8.5;pgsA;CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;0.8859234195189316;-0.016609641779300688;0.27404053393347105;-0.2273120739766794;-1.113235493495611
HELO_2813;29.39256390901276;4.655803407722161;27.63120537886523;47.735826872106664;16.50466606722881;22.290850854107276;5.157129400632692;0.5664245143631745;5.700952148495307;8.918296746086266;3.572881408940461;9.59651247358539;HELO_2813;uncharacterized protein;;;;;;;;;HELO_2813;uncharacterized protein;2.425914506451639;0.2978250647377294;-0.41202380455310283;0.3839550407859118;-2.041959465665727
HELO_2814;37.72722481950146;8.644877930794623;26.0829224916118;23.112653309969414;18.929110472676793;21.353789256381532;2.778757680638633;0.6007268198189079;4.840441511187941;1.071304045885586;2.0430603604529054;2.947076449117517;HELO_2814;FIST domain protein;COG3287;FIST domain protein MJ1623, contains FIST_N and FIST_C domains;FIST;HELO_RS10015;T;;;;HELO_2814;FIST domain protein;2.0055132377956757;0.2768640195140062;-0.1656420900686122;0.7928287144003141;-1.2126845233953616
HELO_2815;26.500581630389846;4.915450968789311;17.438746195148994;23.37743309535935;17.272712777681434;15.114650934379123;2.4208502684880826;0.5985284687074173;1.696451795830896;1.7205871185608597;1.5671999869048674;1.33947236841329;HELO_2815;sensor histidine kinase;COG0784;CheY-like REC (receiver) domain, includes chemotaxis protein CheY  and sporulation regulator Spo0F;CheY;HELO_RS10020;T;;;2.7.13.3;HELO_2815;sensor histidine kinase;2.2169020688013807;0.1943676202118345;0.18131789525326614;0.7710891936309681;-1.4458128751704127
HELO_2816;57.064688795533776;20.74977143625598;46.2509094572232;73.74321132669633;71.04087788062651;45.62880796662649;12.00194083761427;2.1551773940606562;2.61055700209375;8.061551066003231;3.3165328131516114;4.832005812161391;agmR;response regulator/HTH domain transcription regulator AgmR;COG2197;DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains;CitB;HELO_RS10025;KT;agmR; response regulator/HTH domain transcription regulator AgmR;;agmR;response regulator/HTH domain transcription regulator AgmR;1.4166608360156703;0.019120549087823235;0.6275942131988552;0.31643952743615866;-1.1002213085795116
HELO_2817;722.0148217654693;9.427432072773005;2002.0337386844465;792.5676848071074;543.1336394424596;1475.7498395939149;528.8954767490088;3.7472268116676064;171.9844710822773;941.0127501898904;402.30476075759134;570.4904288181923;acoD;acetaldehyde dehydrogenase (NAD);COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS10030;I;acoD; acetaldehyde dehydrogenase (NAD);1.2.1.-;acoD;acetaldehyde dehydrogenase (NAD);6.115569403402414;0.4397612665574169;-1.4403925286599044;-1.0303283274896717;-7.145897730892086
HELO_2818;924.9213922261396;17.273053708417926;1535.458742994422;496.13803975839386;379.03275323255167;1105.0816465863807;637.4561341381728;4.728048893747954;216.69073461608377;572.7724947048008;256.1908947369344;387.67546524662004;adh2;alcohol dehydrogenase%2C zinc-containing;COG1064;D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family;AdhP;HELO_RS10035;G;adh2; alcohol dehydrogenase, zinc-containing;1.1.1.1;adh2;alcohol dehydrogenase%2C zinc-containing;5.663100062711508;0.47415114462593344;-1.5412622154474676;-0.25649625997526826;-5.919596322686776
HELO_2819;30.89563622293358;11.850486025476053;21.217388648829964;32.6140782371189;27.596500959465544;19.63497332347253;1.851709831840676;0.9834398374984089;1.7420484761844723;2.5545127926584397;3.6304236868165276;3.2066609000397155;HELO_2819;uncharacterized protein;;;;;;;;;HELO_2819;uncharacterized protein;1.311536130839519;0.10659768430054317;0.47074705776025283;0.6282674830173871;-0.6832686478221319
HELO_2820;44.804694470423364;10.196181244391948;22.43797277677523;37.87781242767526;22.340875739142813;21.45348110314878;3.056769256472891;1.4850457276170737;1.8374961622798418;2.083520659496183;1.9654416971023088;4.240884829832238;HELO_2820;beta-lactamase domain protein;;;;;;;;;HELO_2820;beta-lactamase domain protein;2.0324887194157872;0.06190865965875059;0.05591955901621226;1.028556333741669;-1.0039323856741182
HELO_2821;29.26765364178637;8.00911048839527;30.153642176168347;49.03351632303028;22.48330180662815;27.24495805399552;2.297211411161819;1.6050059613445802;8.609312408271348;9.657952415849527;1.6039813381445351;3.692348816638545;HELO_2821;PuuR family transcription regulator;COG1917;Cupin domain protein related to quercetin dioxygenase;QdoI;HELO_RS10050;R;;;;HELO_2821;PuuR family transcription regulator;1.7483202671622893;0.14140748060721364;-0.2663580891841688;0.09978348315974639;-1.6485367840025429
HELO_2822;0.7991302905555893;1.1918531220005726;0.5724378944354954;0.7438406709968985;1.524241709257326;0.9150995695193598;0.29647898673272416;0.2593225619261127;0.2614514374512915;0.1473066105509054;0.25061027433330624;0.22966926277882846;HELO_2822;aldolase domain protein;COG0235;5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation);AraD;HELO_RS10055;GE;;;4.1.2.17;HELO_2822;aldolase domain protein;-0.28485145690305524;-0.2844163654115176;0.3984306600334978;-0.09011973407172236;0.1947317228313329
HELO_2823;7.6672623406647515;1.99004825306152;1.5030199551299324;1.0666817956566972;1.8194489456964174;0.9546904825724872;1.1806981717667304;0.35599608550303;0.9821543068410836;1.1873505926890087;0.3582122250704876;0.4246002581765599;HELO_2823;DapA domain protein;COG0329;4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase;DapA;HELO_RS10060;ME;;;4.3.3.7;HELO_2823;DapA domain protein;1.5354076061116493;0.35672961222267574;0.5284730383859411;2.14863619215049;0.6132285860388409
HELO_2824;31.135136913703878;9.56720208844856;16.460350021924864;19.492754033238803;19.51449322722678;23.840843748618024;2.4250368802202895;0.25083286933222165;1.5886197643766877;0.8990450076189559;1.4608050692882644;15.296011084266647;HELO_2824;RhbE family siderophore biosynthesis protein;COG3486;Lysine/ornithine N-monooxygenase;IucD;HELO_RS10075;Q;;;1.14.13.59;HELO_2824;RhbE family siderophore biosynthesis protein;1.6045581787292864;-0.5086316967400979;-0.27607066168616345;0.37143744184466954;-1.2331207368846169
HELO_2825;7.973920753026559;3.033830664112996;5.107247537563475;4.964567533507344;3.956292804090237;7.514154111653518;0.20993597815888532;0.26460484279729696;1.826932698949272;0.33788896773805494;0.32441606291827907;6.035922742598776;HELO_2825;condensation/AMP-dependent ligase domain protein;COG1020;EntF, seryl-AMP synthase component  of non-ribosomal peptide synthetase;EntF;HELO_RS10080;Q;;;;HELO_2825;condensation/AMP-dependent ligase domain protein;1.1535879214764626;-0.4793408827096659;-0.7806017836273886;0.07587523984516409;-1.0777126816312985
HELO_2826;2.873379560487747;1.6346196807050248;2.758568464293292;0.851603242058616;2.1308468426219083;6.964697152565584;0.8278917578877195;0.3228189749586223;2.2598575471911415;0.35352251624077186;0.3361036074209633;9.342105867268579;hdc;histidine decarboxylase;COG0076;Glutamate or tyrosine decarboxylase or a related PLP-dependent protein;GadA;HELO_RS10090;E;hdc; histidine decarboxylase;4.1.1.22;hdc;histidine decarboxylase;0.5559981636463207;-1.083436222636921;-1.3470665709145664;-1.0400266251882313;-1.596024788834552
HELO_2827;9.998572138450013;4.329716823849933;9.098207827936681;5.403591807163981;9.24358559944874;29.76902163589358;0.4505730386211439;0.8421402137346568;3.3406325482445367;0.7237608382973252;0.8779711877124124;41.101622835500216;HELO_2827;TonB-dependent receptor;COG4771;Outer membrane receptor for ferrienterochelin and colicins;FepA;HELO_RS10095;P;;hdc;;HELO_2827;TonB-dependent receptor;1.0451854542052947;-1.6073792965095932;-1.5867577754326812;-1.484162329249318;-2.5293477834546128
HELO_2828;11.027849305832474;3.1811114568156706;9.213973967713022;7.434986062384984;9.306823556788428;20.900272711784336;1.5200696614373974;0.4532013566842789;1.4119201959806258;0.23178032117837458;0.24355670631819623;23.018391238477246;HELO_2828;condensation domain protein;COG1020;EntF, seryl-AMP synthase component  of non-ribosomal peptide synthetase;EntF;HELO_RS10100;Q;;;;HELO_2828;condensation domain protein;1.5244202906931834;-1.1004045478281306;-1.0873490556444336;-0.8645701370663659;-2.3889904277595493
HELO_2829;81.51747339974085;30.674308200765626;64.26481894340064;47.0152334986592;67.84536933693182;128.6186855912702;1.9750438794702627;1.1228139237203227;20.04598708381522;3.0945997994959233;2.706781613166968;131.60679756074583;fatB;ABC-type transport system periplasmic substrate-binding protein (probable substate siderophore iron);COG4607;ABC-type enterochelin transport system, periplasmic component;CeuA;HELO_RS10105;P;fatB; ABC-type transport system periplasmic substrate-binding protein (probable substate siderophore iron);;fatB;ABC-type transport system periplasmic substrate-binding protein (probable substate siderophore iron);1.3813865382833725;-0.9898962890611829;-0.9128421849986577;-0.6515021563045131;-2.0328886945878857
HELO_2830;19.368875924800275;6.297794474808554;11.12478583289682;9.349842797620177;8.229997922114753;19.967893978041783;2.037392923786341;0.3724042023085061;3.1812572648476656;0.8444988693182701;2.1967125361687323;17.74865609960757;fatE;ABC-type transport system ATP-binding protein (probable substate siderophore iron);COG4604;ABC-type enterochelin transport system, ATPase component;CeuD;HELO_RS10110;P;fatE; ABC-type transport system ATP-binding protein (probable substate siderophore iron);7.2.2.-;fatE;ABC-type transport system ATP-binding protein (probable substate siderophore iron);1.4808339395448717;-0.7902226995930519;-1.183779735761326;-0.04181559791669098;-1.5226495374615627
HELO_2831;10.096996318654185;2.9610851613297076;5.6628785780781135;4.36735436293898;3.3300598164085464;7.252264595724781;1.9582983975661497;0.939664360195151;1.8806968475133388;0.8811491716889107;1.2245457218811249;7.204248329333244;fatC;ABC-type transport system permease protein (probable substate siderophore iron);COG4605;ABC-type enterochelin transport system, permease component;CeuC;HELO_RS10115;P;fatC; ABC-type transport system permease protein (probable substate siderophore iron);;fatC;ABC-type transport system permease protein (probable substate siderophore iron);1.486201603789367;-0.30864447699945474;-0.9304031248858373;0.4273072428944258;-1.0588943608949413
HELO_2832;2.3816195899644246;1.1316295411103594;4.207831442184799;2.6162290010034934;3.008857185101448;5.019885648902622;0.19621211401338426;0.325310221210817;1.7651881906332267;0.3338578818867922;0.583920294242102;4.390026428265727;fatD;ABC-type transport system permease protein (probable substate siderophore iron);COG4606;ABC-type enterochelin transport system, permease component;CeuB;HELO_RS10120;P;fatD; ABC-type transport system permease protein (probable substate siderophore iron);;fatD;ABC-type transport system permease protein (probable substate siderophore iron);0.6657576432554213;-0.20905332777051067;-0.5865450598222903;-0.8320217073042182;-1.4977793505596395
HELO_2833;6.169753020855995;1.69846484175354;8.96232821918784;5.728828300209366;7.473467277399462;11.205582813975711;0.76535314109378;0.3431173670778439;4.289101677750233;0.4451809661872395;0.13537231977468084;8.216165081077005;HELO_2833;ABC-type transport system ATP-binding/permease protein;COG1132;ABC-type multidrug transport system, ATPase and permease component;MdlB;HELO_RS10125;V;;fatD;7.-.-.-;HELO_2833;ABC-type transport system ATP-binding/permease protein;1.409784532144372;-0.2929863371606425;-0.5265168499860553;-0.7675458573001674;-2.1773303894445393
HELO_2834;5.9355683192261735;1.9686872074951811;9.57261791543687;4.169319618076535;4.643198310752705;14.618087654561263;0.8880450712667683;0.23369092435949654;8.179492543427399;0.4520588670233234;0.4243652532124874;18.179303106700534;HELO_2834;ABC-type transport system ATP-binding/permease protein;COG1132;ABC-type multidrug transport system, ATPase and permease component;MdlB;HELO_RS10130;V;;;7.-.-.-;HELO_2834;ABC-type transport system ATP-binding/permease protein;1.2241890123910166;-0.5628851638420334;-1.4686328604137797;-1.1711318037048617;-2.3953208160958783
HELO_2835;2.786239080637564;0.8787541891085997;3.174253154050721;0.8346335653636859;2.134766368176979;6.033336445359105;0.3392253887854959;0.17726846501655227;3.3494648050608133;0.13228662685946288;0.4738055228746946;8.20826057277126;entC;isochorismate synthase;COG1169;Isochorismate synthase EntC;MenF;HELO_RS10135;HQ;entC; isochorismate synthase;5.4.4.2;entC;isochorismate synthase;1.0109891913906646;-0.7526911338178368;-1.1658513074074217;-0.8934437190933731;-1.9044329104840378
HELO_2836;1.7379977651594263;0.7961794079058944;1.6732116046884478;0.5607924241649581;1.5600265469374317;3.312391106214619;0.2527078779721038;0.2517266026400321;1.765371414464328;0.22367390786684044;0.483832688244031;4.156244596952694;entE;enterobactin synthase component EntE;COG1021;EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase;EntE;HELO_RS10140;Q;entE; enterobactin synthase component EntE;6.3.2.14,2.7.7.58;entE;enterobactin synthase component EntE;0.6081898109430887;-0.6899139850092786;-0.7523292564638717;-0.6553667581883151;-1.2635565691314037
HELO_2837;2.9438260277610877;1.6249128544704512;2.649524195186432;1.2519888835681792;3.16043136235943;5.1573613001454675;0.501952827369829;0.5624723645896846;1.325716497939615;0.3293898994427554;0.8983240107229049;6.4452786597227725;entB;enterobactin synthase component EntB;COG3433;Acyl carrier protein/domain;AcpA;HELO_RS10145;IQ;entB; enterobactin synthase component EntB;3.3.2.1,6.3.2.14;entB;enterobactin synthase component EntB;0.5873263851911408;-0.7546038395055292;-0.5655791073375336;-0.6427163129882354;-1.2300426981793762
HELO_2838;3.5832667532567233;1.6968793284386345;2.7342601156222828;2.40944614098972;2.8104865241125676;6.272570604056991;0.5626251713631223;0.1578025137142412;1.0782627405368055;1.18360046464161;0.38817470390883346;6.046450679956435;entA;2%2C3-dihydro-2%2C3-dihydroxybenzoate dehydrogenase;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS10150;I;entA; 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase;1.3.1.28;entA;2%2C3-dihydro-2%2C3-dihydroxybenzoate dehydrogenase;0.7650852854612731;-0.9616429732595841;-0.9324901842284208;-0.666089142210105;-1.431174427671378
HELO_2839;45.37970510321272;7.652997999002778;26.683453881579364;35.4412215599996;34.43996799458989;26.611291569551693;1.1472023314426587;0.9800802673782677;3.053752887881976;2.698593430382505;2.77497402040433;3.258375026098721;HELO_2839;RutC family protein;COG0251;Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family;RidA;HELO_RS10155;V;;entA;;HELO_2839;RutC family protein;2.4222216727483437;0.0037655754794085894;0.36011892676293655;0.7482352726531758;-1.6739864000951679
HELO_2840;79.32507058790542;15.700290179313383;27.644877990801614;31.364794416365232;24.78802694718375;26.53313895543316;5.2947751922964175;0.8194973654423802;1.9188068824153643;2.7455069594765504;1.0476619746020406;1.563187764164237;HELO_2840;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS10160;T;;;2.7.13.3;HELO_2840;sensor histidine kinase;2.265977172745554;0.05710809695786967;-0.09446769970648639;1.5446812476558094;-0.7212959250897448
HELO_2841;27.75915348476263;4.771404971920184;7.24051942220768;8.114453033161034;5.485109747278657;5.998517833221501;0.6065130180341802;0.11038644099936967;1.4891679844034713;1.056398207170357;0.5116676619520555;0.24245271722238962;HELO_2841;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS10165;KT;;;;HELO_2841;response regulator/HTH domain transcription regulator;2.31702673950449;0.23568586105183353;-0.10991842683005704;2.0388998898951702;-0.27812684960931966
HELO_2842;37.9118082838721;11.749950555398849;13.352862213252495;15.357586974168095;11.506484344220935;10.664631888933263;3.4765503462346277;1.8592452902944092;1.6962379656752933;2.9153479274772156;0.640078001863918;1.8370044414686737;HELO_2842;MipA family protein;COG3713;Outer membrane scaffolding protein for murein synthesis, MipA/OmpV family;OmpV;HELO_RS10170;M;;;;HELO_2842;MipA family protein;1.6097163735498938;0.29919768472323893;0.10053551569878172;1.7380672461985047;0.1283508726486109
HELO_2843;11.109172754911247;7.684270461623961;12.172037662330949;10.90746479436118;12.59827460661507;12.452475329409276;0.8334699147773078;0.7998132343880908;0.6693622240195233;0.6638719442553253;0.5987847283981982;0.9265480227379467;HELO_2843;major facilitator superfamily transport protein;;;;;;;;;HELO_2843;major facilitator superfamily transport protein;0.4796237470141036;-0.03039311892880514;0.015551948214454825;-0.15177135116771323;-0.6313950981818168
HELO_2844;18.7020730816726;6.545029060567683;19.529079784299324;18.53859240084525;21.03975830186673;18.130504338360172;0.3482775089379364;0.6591681118586921;1.6156654338947751;0.97873077208;0.9553631936414169;2.336985496076472;HELO_2844;probable oxidoreductase (short-chain dehydrogenase family);COG0300;Short-chain dehydrogenase;YqjQ;HELO_RS10185;R;;;;HELO_2844;probable oxidoreductase (short-chain dehydrogenase family);1.384749077619066;0.10179405209110648;0.20423349471733232;0.042472532183483125;-1.342276545435583
HELO_2845;76.8441596951;34.60098585618293;80.7805107103059;68.08065069767203;74.16240956000571;82.03307664628512;5.059119718681895;2.660868461867315;8.325715301045186;2.0047893950883653;13.081258105153777;3.8483477663737378;HELO_2845;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS10190;K;;;;HELO_2845;LysR family transcription regulator;1.128671611701412;-0.02192908346434752;-0.1436748383450661;-0.09309735152749354;-1.2217689632289055
HELO_2846;9.407253642458238;2.8025523238635714;7.126566053545537;13.618561004273069;7.002860797519522;5.684671662789257;0.9727807026491595;0.11797492848679915;1.2887728641215126;0.8185025968770513;1.3756214898596206;1.7274027729230597;HELO_2846;non-ribosomal peptide synthetase AT domain protein;COG3320;Thioester reductase domain of alpha aminoadipate reductase Lys2 and NRPSs;Lys2b;HELO_RS10200;Q;;entD;;HELO_2846;non-ribosomal peptide synthetase AT domain protein;1.4525494028516703;0.2817891586936563;0.2596591152071035;0.6386608028338729;-0.8138886000177974
HELO_2847;8.120599671068947;2.213113650835664;3.0056802127680036;4.130618977510334;4.903571895454456;2.8605009346479022;0.8955776482583118;0.6516515162624154;0.7222455946921871;0.7235113578421994;0.5916859009131911;1.0981709560380988;HELO_2847;SirB domain protein;COG3094;Uncharacterized membrane protein SirB2;SirB2;HELO_RS10210;S;;;;HELO_2847;SirB domain protein;1.5051566722000942;0.05325918816830644;0.6128000441715362;1.2403406211140235;-0.26481605108607065
HELO_2848;7.278169657898293;2.101295386339633;4.342584813831284;6.561853165747497;8.127928336593937;4.530883859212143;0.2492849295940656;0.14469740834264475;0.5866310949673376;0.617876338242568;0.9247342476526859;0.26428396130519954;HELO_2848;NnrS family protein;COG3213;Nitric oxide response protein NnrS;NnrS;HELO_RS10215;T;;;;HELO_2848;NnrS family protein;1.416440872756436;-0.0499721418726784;0.7227774172622277;0.5818017685466832;-0.8346391042097527
HELO_2849;17.291841365826055;3.089479418526866;7.502471069341328;11.579214966710632;12.957581887456989;6.110830687789925;0.615740599193217;0.03566482432033654;0.7243246707128083;1.3616105947159758;1.3013422358471647;0.1994898148513832;hemN;coproporphyrinogen III oxidase%2C oxygen-independent;COG0635;Coproporphyrinogen-III oxidase HemN  (oxygen-independent) or related Fe-S oxidoreductase;HemN;HELO_RS10220;H;hemN; coproporphyrinogen III oxidase, oxygen-independent;1.3.98.3;hemN;coproporphyrinogen III oxidase%2C oxygen-independent;2.1612112045277505;0.2578640865660735;0.9729590097132927;1.3631103021342623;-0.7981009023934882
HELO_2850;19.71992141522344;3.43988550597588;6.627374090114702;14.888357362655887;16.920890914672647;6.566075653039611;2.618104746401081;0.14130511209514113;1.320454813658095;2.1271083385936267;0.508572039434591;0.8255734044026221;HELO_2850;PpiC-type peptidyl-prolyl cis-trans isomerase family protein;COG0760;Peptidyl-prolyl isomerase, parvulin family;SurA;HELO_RS10225;O;;hemN;5.2.1.8;HELO_2850;PpiC-type peptidyl-prolyl cis-trans isomerase family protein;2.222424152787879;0.01164125758318324;1.244025253906492;1.4534014242513438;-0.7690227285365352
HELO_2851;9.860834790672747;1.327674476348916;1.9672573499706651;5.362456736477622;7.070516490520787;2.4459248113858183;0.7180176397466579;0.29375334090681005;0.1149598479682221;1.0576376063387722;0.30856145030052184;0.36217876080592576;narI;respiratory nitrate reductase gamma subunit;COG2181;Nitrate reductase gamma subunit;NarI;HELO_RS10230;CP;narI; respiratory nitrate reductase gamma subunit;1.7.5.1,1.7.99.-;narI;respiratory nitrate reductase gamma subunit;2.222173778948753;-0.21576116585457483;1.2277697819979423;1.6561718684930566;-0.5660019104556961
HELO_2852;14.257035069347713;2.2391316200871905;5.345698115817744;7.522348880206626;9.369806341996062;3.981177373581932;1.2292243602918125;0.21949067411446702;0.7312284594359003;0.9336359107981378;1.0709646054600728;0.3016990224585852;narJ;nitrate reductase molybdenum cofactor assembly chaperone NarJ;COG2180;Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor;NarJ;HELO_RS10235;OCP;narJ; nitrate reductase molybdenum cofactor assembly chaperone NarJ;;narJ;nitrate reductase molybdenum cofactor assembly chaperone NarJ;2.2357956301019932;0.3492921049758899;1.0578302621839515;1.6149159379207054;-0.6208796921812878
HELO_2853;12.88915490191628;2.1429090150403947;4.1824797490883805;8.550336708839;13.229532901680935;3.4735006293832598;0.984745839366248;0.3233111396882769;0.6866306614317487;1.0908814620622178;2.0341304271905662;0.5121757274646948;narH;respiratory nitrate reductase beta subunit;COG1140;Nitrate reductase beta subunit;NarY;HELO_RS10240;CP;narH; respiratory nitrate reductase beta subunit;1.7.5.1,1.7.99.-;narH;respiratory nitrate reductase beta subunit;2.1437864070482915;0.2122383545552955;1.669412180298885;1.6344826954478142;-0.5093037116004773
HELO_2854;17.415243528302835;1.5419745629405857;12.293940389691649;12.848337574914865;39.251791130452624;11.54972609748328;2.891914395730641;0.21667511027634778;7.01680095294756;2.1315426238687962;14.265444726047745;6.33842752399102;narG;respiratory nitrate reductase alpha subunit;COG5013;Nitrate reductase alpha subunit;NarG;HELO_RS10245;CP;narG; respiratory nitrate reductase alpha subunit;1.7.5.1,1.7.99.-;narG;respiratory nitrate reductase alpha subunit;2.8568789772134133;0.08311291279288424;1.6813971047686493;0.5532445988093748;-2.3036343784040385
HELO_2855;26.574307717222762;8.24716854158671;13.017468407112771;15.379355988828621;15.63804613139928;12.304677619951674;1.2983354581562878;0.44811490986211777;0.5547283970885503;0.43541471505085744;1.9615138802642993;2.876154382763182;narX;sensor histidine kinase NarX;COG3850;Signal transduction histidine kinase NarQ, nitrate/nitrite-specific;NarQ;HELO_RS10250;T;narX; sensor histidine kinase NarX;2.7.13.3;narX;sensor histidine kinase NarX;1.576241076879565;0.0752922647823766;0.32255246885144473;1.0513911124073108;-0.5248499644722542
HELO_2856;46.66105645425224;13.135304541173303;25.151256120376996;25.344850879197512;32.64171978385097;26.83107608327869;3.6015310434463044;1.024304752256334;1.236495007331797;4.1982949195094035;2.9939254169159604;3.466263381537762;narL;response regulator/HTH domain transcription regulator NarL;COG2197;DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains;CitB;HELO_RS10255;KT;narL; response regulator/HTH domain transcription regulator NarL;;narL;response regulator/HTH domain transcription regulator NarL;1.753507964674836;-0.08981644633110086;0.2735547675912384;0.7761142393608429;-0.977393725313993
HELO_2857;10.535791261253983;2.0201659585068175;6.378306020882192;6.291170486062774;22.78538527291199;6.736490161925578;1.0086439098096032;0.16921049629795773;3.0445490825399655;1.221720514443569;8.035286396615021;3.2284406798009213;HELO_2857;major facilitator superfamily transport protein (probable substrate nitrate/nitrite);COG2223;Nitrate/nitrite transporter NarK;NarK;HELO_RS10260;P;;narL;;HELO_2857;major facilitator superfamily transport protein (probable substrate nitrate/nitrite);1.9334172314167424;-0.06838957559544667;1.6203242862352196;0.5763658566741294;-1.357051374742613
HELO_2858;4.380030794988969;0.8029264759808364;2.0255749000956356;3.6255519101389275;6.6518676043180776;2.5392593356263995;0.8254545845480782;0.1495723014895547;0.3908922734384708;0.3392177024918373;1.0481690983150274;1.2831321456586076;HELO_2858;major facilitator superfamily transport protein (probable substrate nitrate/nitrite);COG2223;Nitrate/nitrite transporter NarK;NarK;HELO_RS10265;P;;;;HELO_2858;major facilitator superfamily transport protein (probable substrate nitrate/nitrite);1.5772738663855703;-0.22623817766912957;1.1123644341644214;0.6041669530621514;-0.9731069133234189
HELO_2859;4.918446888609335;1.3552718841746654;1.7031449018157676;2.4289385984684366;3.6854401785518665;1.7494724560172008;0.666675224177148;0.38758314757633006;0.6180651986425515;0.23932486473720155;0.29769344418370064;0.11921016801666556;HELO_2859;DUF1282 domain protein;;;;;;;;;HELO_2859;DUF1282 domain protein;1.329325026287305;-0.02451598440350855;0.7690297558635313;1.1060638014272313;-0.22326122486007383
HELO_2860;11.064978810268288;7.126677622689898;92.12171269092926;71.61826041064036;50.45251466456144;66.19341955944644;0.9477737374870697;0.6869931442977009;17.692928579341825;10.335145326126582;24.547223566137195;45.37649994170217;HELO_2860;cupin domain protein;;;;;;;;;HELO_2860;cupin domain protein;0.5700878115342656;0.4707976397423703;-0.38507836433827514;-2.4774945709896294;-3.047582382523895
HELO_2861;9.788975653139238;1.8610387951461724;18.459556751635944;37.337450493132955;212.0421527965027;11.121784289035515;0.8306027824662927;0.3947673986704271;8.301320775619551;15.599840703164542;202.5772164466278;8.145675933223496;HELO_2861;uncharacterized protein;;;;;;;;;HELO_2861;uncharacterized protein;1.9149469307309317;0.6828767742155226;4.135464932417785;-0.16804417836555174;-2.0829911090964837
HELO_2862;25.63117242421312;4.061363512400031;27.24005284366642;42.999601135178104;26.355916838267103;21.414854268138807;1.3869057751052793;0.48046854950214374;8.17907951266658;13.27840982288422;8.858918741552186;2.6063764984096256;HELO_2862;uncharacterized protein;;;;;;;;;HELO_2862;uncharacterized protein;2.395517944842212;0.33328766859875536;0.2873977890749355;0.2486608242545394;-2.1468571205876725
HELO_2863;88.10332234989379;58.92022189741723;55.295897959142934;50.71139900450027;64.68594842499935;56.42952407296405;4.292282228930155;3.231438996175431;2.0420566738477013;1.7144106190783663;3.9350157028435397;7.318273730935859;HELO_2863;YeeA family protein;COG1289;Uncharacterized membrane protein YccC;YccC;HELO_RS10295;S;;;;HELO_2863;YeeA family protein;0.5724362593650296;-0.028762802814840782;0.19379217547491745;0.6336866198359719;0.06125036047094223
HELO_2864;97.65238993481192;56.93176720596466;97.38151132794017;116.12839313723354;131.1967024512177;103.1275607020997;1.641226425699304;2.182275027515699;7.246488864066622;7.682872300334065;6.852106560507699;4.281741641916883;nadB;L-aspartate oxidase;COG0029;Aspartate oxidase;NadB;HELO_RS10300;H;nadB; L-aspartate oxidase;1.4.3.16;nadB;L-aspartate oxidase;0.7679993268106076;-0.08189285184797246;0.34433421559198685;-0.07792606779186073;-0.8459253946024683
HELO_2865;389.8530469774958;123.38906449251674;185.97942639251687;251.4476150028204;253.11438183831322;198.0056636542753;22.715507611833104;15.27475362492151;13.265112716640093;13.355038381888143;12.357027729983352;9.269528423174036;HELO_2865;uncharacterized protein;;;;;;;;;HELO_2865;uncharacterized protein;1.6517666263183335;-0.08992995301910245;0.35266853824722766;0.9738167945355372;-0.6779498317827963
HELO_2866;147.81819765809067;65.80705576526833;130.12852002630333;118.92113867410679;130.0487729020085;119.98152655325113;23.187505517573534;21.054609520932118;22.29452748979152;17.47093656425088;28.99450859889407;20.52201305620013;HELO_2866;DUF339 family protein;COG2938;Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module;SdhE;HELO_RS10310;O;;;;HELO_2866;DUF339 family protein;1.1554785668615608;0.11619473122318791;0.11531707486318421;0.29876418167938557;-0.8567143851821752
HELO_2867;294.69769381032376;265.7699265383647;435.8061110151413;483.0796901395898;488.4640232160586;461.750700710011;17.232814887658282;38.5630620630151;27.85245499052272;20.546645522261187;19.934219351396006;2.5136103171050066;ihfB;HU-type DNA-binding protein IhfB;COG0776;Bacterial nucleoid DNA-binding protein IHF-alpha;HimA;HELO_RS10315;L;ihfB; HU-type DNA-binding protein IhfB;;ihfB;HU-type DNA-binding protein IhfB;0.1485269536729774;-0.08324213464146268;0.08096764750102814;-0.6461121829546244;-0.7946391366276018
HELO_2868;421.8521210748142;288.70666625460575;192.44050606221685;225.76349408303705;220.4657916672056;219.27714578368628;22.45470511031541;18.515878277785465;22.718848717515748;5.643195630126883;34.73156928455763;31.057282718824187;HELO_2868;LapA domain protein;;;;;;;;;HELO_2868;LapA domain protein;0.5455603334495702;-0.18742989620617045;0.00776405241569833;0.9408333952077053;0.39527306175813504
HELO_2869;166.81739778101516;140.6755833262831;73.72696108950808;90.15785177916284;85.18055714112499;68.37152234248641;3.0802965856176368;8.699169265850037;4.386118640517621;2.2088603549439427;4.786556396249244;2.157536177665027;lapB;lipopolysaccharide assembly protein LapB;COG2956;Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain;LapB;HELO_RS10325;M;lapB; lipopolysaccharide assembly protein LapB;;lapB;lipopolysaccharide assembly protein LapB;0.2443011465044158;0.10728530907455092;0.31301888068284356;1.2744768393665344;1.0301756928621186
HELO_2870;258.19678753929094;139.87197678987528;331.47713099933054;444.28532918170004;463.52669147499154;292.9392544055219;2.033692240978092;8.874360156345874;25.889154879955992;17.129174490156505;47.97129383617961;13.482914401117391;pyrF;orotidine 5'-phosphate decarboxylase;COG0284;Orotidine-5'-phosphate decarboxylase;PyrF;HELO_RS10330;F;pyrF; orotidine 5'-phosphate decarboxylase;4.1.1.23;pyrF;orotidine 5'-phosphate decarboxylase;0.8796631882105297;0.17773707217506818;0.6602434575593374;-0.18147020027092076;-1.0611333884814504
HELO_2871;2.9480341236645997;0.7430692937054494;1.1653445878130546;2.0104380163906588;1.3237619834050582;1.6835824423924752;0.6401317363073282;0.46572924776114455;0.1176331765570071;0.3983245837832936;0.39016130264166254;0.436327556718061;HELO_2871;YbaV family protein;COG1555;DNA uptake protein ComE or related DNA-binding protein;ComEA;HELO_RS10335;L;;pyrF;;HELO_2871;YbaV family protein;1.1795045360780765;-0.3095635795600449;-0.20769790486032025;0.5569742494994627;-0.6225302865786138
HELO_2872;189.00645924380024;55.3272920437669;316.6391938174434;404.672221685607;498.5006087247707;303.8652930222599;5.3373358866311795;1.4079420185786062;33.44726235919749;13.390633116719968;58.10890727180963;15.759757226989153;HELO_2872;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS10340;I;;;1.1.1.100;HELO_2872;probable oxidoreductase (short-chain dehydrogenase family);1.7541424433738406;0.05921702102038573;0.7123145181567239;-0.6821234544144552;-2.436265897788296
HELO_2873;48.84544128432865;40.49913743075001;49.96038274949195;136.47906012557846;35.058230775179446;45.949035922796696;5.781980498985776;7.08717936885899;1.1281772138488968;30.736811021882218;1.844641604453806;2.7947044834512593;HELO_2873;FxsA family protein;COG3030;FxsA protein affecting phage T7 exclusion by the F plasmid, UPF0716 family;FxsA;HELO_RS10345;R;;;;HELO_2873;FxsA family protein;0.2643802160448505;0.11828058022911225;-0.38076692152827984;0.08636603296963674;-0.17801418307521377
HELO_2874;1937.9506717883003;1049.4545987519925;1466.5658196881188;2792.9192821071806;1226.9129097984069;1423.868023774747;170.24468507269458;130.18174726029525;156.78701670534065;146.49426871260175;64.40879538556253;92.81320473420364;groES;molecular chaperone GroES;COG0234;Co-chaperonin GroES (HSP10);GroES;HELO_RS10350;O;groES; molecular chaperone GroES;;groES;molecular chaperone GroES;0.8842622915231786;0.04259691099084684;-0.2146200574113557;0.4444478027375194;-0.4398144887856592
HELO_2875;3585.360801165092;1501.655535787915;2198.8376109994456;4391.364286087944;2415.9009377977127;2120.545374212219;468.4205657341515;53.561526807610335;346.99546413742195;139.105002887799;277.8076296573486;359.01463829176447;groEL;molecular chaperone GroEL;COG0459;Chaperonin GroEL (HSP60 family);GroEL;HELO_RS10355;O;groEL; molecular chaperone GroEL;;groEL;molecular chaperone GroEL;1.2550063078607856;0.05228149553988537;0.18804280779768057;0.7574051015983265;-0.4976012062624591
HELO_2876;65.1867279014702;76.32561323014313;69.51973546728252;73.71940065004021;75.94531602711932;65.72106621056577;1.0402883135011152;0.08981080145947082;3.0205843680452586;1.8770882685583379;8.990909129628664;4.299364736433336;trmJ2;tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ;COG0565;tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase;TrmJ;HELO_RS10360;J;trmJ2; tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ;2.1.1.200;trmJ2;tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ;-0.22440442013716666;0.07988471944435194;0.20569116313394709;-0.011600393900997652;0.212804026236169
HELO_2877;10.195098808533947;3.8417355383586025;7.422867947964466;12.007302853394341;12.771079887527046;7.4581358053678635;0.6350263795537892;0.2109612203948764;1.264260835133716;1.924830820605825;0.764936085029005;1.7226264039494588;ilvE1;branched-chain amino acid aminotransferase;COG0115;Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase;IlvE;HELO_RS10365;EH;ilvE1; branched-chain amino acid aminotransferase;2.6.1.42;ilvE1;branched-chain amino acid aminotransferase;1.2092710767526227;-0.006028176730481949;0.7032300659655499;0.4044556317099426;-0.8048154450426801
HELO_2878;17.232210387156226;6.438583391246664;13.639943784489907;23.59226469248468;25.618803768106602;14.340303851884793;0.2638877263375119;0.5015773893873247;1.880068260129013;1.1120108639673436;1.302026258443101;1.7109797538207545;HELO_2878;histone deacetylase superfamily protein;COG0123;Acetoin utilization deacetylase AcuC or a related deacetylase;AcuC;HELO_RS10370;Q;;ilvE1;;HELO_2878;histone deacetylase superfamily protein;1.2933896727154695;-0.0674170453262426;0.795118679726253;0.24916241832491925;-1.0442272543905502
HELO_2879;15.395309373672832;3.8537671364515966;10.792961509999794;17.769708712235143;24.492629686196505;10.760311334722934;1.2232862192944005;0.1550736416356897;0.7405641002705277;0.6415534079244245;3.4617614785130657;1.4264662611521732;HELO_2879;OCD family protein;COG2423;Ornithine cyclodeaminase/archaeal alanine dehydrogenase, mu-crystallin family;OCDMu;HELO_RS10375;E;;;;HELO_2879;OCD family protein;1.7561063243739397;0.003999807282739631;1.1161539482662883;0.47935687149508244;-1.2767494528788572
HELO_2880;8.659059408747963;2.2036922422857503;2.639774109887719;4.182589988909729;5.883550660968351;2.7875791877991465;1.2814788184482826;0.13475572928453727;0.5800696826272858;0.47988015482198954;0.7343635060956426;0.4611813704782086;HELO_2880;RutC family protein;COG0251;Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family;RidA;HELO_RS10380;V;;;;HELO_2880;RutC family protein;1.5921471432988687;-0.057427134385334755;0.8618768736724576;1.350606655784028;-0.2415404875148408
HELO_2881;7.231636933534399;2.3772762685200526;6.5899981665357;9.94092770350548;11.392262974133942;6.0933714261472085;0.7179077213028087;0.3441100931737661;0.6785033853536981;0.7345317136105088;1.3602211464042726;1.041567364304535;HELO_2881;histone deacetylase superfamily protein;COG0123;Acetoin utilization deacetylase AcuC or a related deacetylase;AcuC;HELO_RS10385;Q;;;;HELO_2881;histone deacetylase superfamily protein;1.2853191520424763;0.0976280445536255;0.8048962670566788;0.21470785921180813;-1.0706112928306681
HELO_2882;3.575160040992923;1.0907007019455277;2.9297122405421505;5.120214917427476;4.648752715720486;2.914432864607511;0.4553170666333412;0.21127528168443913;0.43511256947996535;0.6105809529549076;0.7912949778682448;0.4124452548923785;HELO_2882;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS10390;G;;;;HELO_2882;TRAP transporter large transmembrane protein;1.1298356652677288;0.005620372257898243;0.5291290450489889;0.2250189099051514;-0.9048167553625774
HELO_2883;3.705498598435863;1.5479867857875356;4.207707862424655;8.444865459233155;5.990773853211693;2.6093568146102424;0.5912167341997193;0.21155571973128287;1.3715357637337222;1.1291067372978798;1.636553362484256;0.17160094334410547;HELO_2883;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS10395;G;;;;HELO_2883;TRAP transporter small transmembrane protein;0.8849898045891329;0.5289067471345021;0.9537103929714854;0.3826058276292732;-0.5023839769598597
HELO_2884;7.390690050453029;2.11132853859416;9.512167414366827;21.07434497991822;18.1963337754089;9.191686718642154;1.4206110357869326;0.1443583129763922;1.670530143710426;2.36362382639225;2.625494829308486;0.6927513103283024;HELO_2884;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS10400;G;;;;HELO_2884;TRAP transporter substrate-binding protein;1.4312587194968502;0.04466732047312405;0.9134379666683823;-0.28053146859829114;-1.7117901880951414
HELO_2885;19.194541531435874;5.60298852081932;15.040784230756037;19.726038288987453;24.799946716606627;14.398845466051249;2.4450698584155326;0.1173554814787439;2.605455196014646;1.9475119869967785;2.5812592718436775;1.465149864416588;HELO_2885;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS10405;K;;;;HELO_2885;AraC family transcription regulator;1.6127743505215952;0.05892248819317647;0.7445458977247066;0.39114320508882816;-1.221631145432767
HELO_2886;94.86593204777193;18.95282847544014;36.51788618974437;26.811947501432115;38.41049552097165;47.57522464831185;5.341946327629849;0.850221742987453;1.6300919714906899;2.877235521348459;0.5097526611405832;2.821810434197913;HELO_2886;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG0604;NADPH:quinone reductase or related Zn-dependent oxidoreductase;Qor;HELO_RS10410;CR;;;;HELO_2886;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);2.2644249399593948;-0.37264212124740936;-0.3016407788676556;0.9807975467087244;-1.2836273932506703
HELO_2887;101.06561391501891;23.872459159527995;39.07177740282837;38.00127212041766;49.38759237781722;47.60028197418314;6.2674792591448325;1.3379555062100292;1.9381224651479638;2.333040774128805;5.662038844659978;7.301210322200045;HELO_2887;proline racemase family protein;COG3938;Proline racemase/hydroxyproline epimerase;PrdF;HELO_RS10415;E;;;4.2.1.77;HELO_2887;proline racemase family protein;2.0368758414649797;-0.2783781816182165;0.05210383880200542;1.070460312227139;-0.9664155292378407
HELO_2888;11.061863560798052;8.404424895926295;10.75246907598229;10.712484966892484;17.84110263187465;11.510100394071744;0.687227389655073;1.0969558058160185;2.8016855393735876;0.8795947765206295;0.40535395175146127;1.0511182917823687;qdoI;quercetin 2%2C3-dioxygenase;COG1917;Cupin domain protein related to quercetin dioxygenase;QdoI;HELO_RS10420;R;qdoI; quercetin 2,3-dioxygenase;1.13.11.24;qdoI;quercetin 2%2C3-dioxygenase;0.3590411940334981;-0.09012948283302391;0.5907900305683182;-0.05264054605079904;-0.41168174008429714
HELO_2889;2.1924753760083076;2.84179536717954;3.2031448628074357;3.4547839954657236;3.8487276854148647;2.9741526588567915;0.27127247885130973;0.2898048832503597;1.0102738586861437;0.5017133055100781;0.8243889911641479;0.3526698091339805;HELO_2889;alpha/beta hydrolase fold protein;COG2272;Carboxylesterase type B;PnbA;HELO_RS10425;I;;qdoI;3.1.1.-;HELO_2889;alpha/beta hydrolase fold protein;-0.2671051837823222;0.08082188851982042;0.28695893947026385;-0.315971799528701;-0.04886661574637885
HELO_2890;45.845470417722915;31.420987650277606;66.36402439903905;61.34075532956373;71.62633551541519;65.41863343267404;2.7277241995488466;1.8961153943066733;0.32296534355205164;0.6388408338388297;5.709294015697005;4.2659950760882985;HELO_2890;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS10430;K;;;;HELO_2890;LysR family transcription regulator;0.5309815167807468;0.020390289517491667;0.12890474866634616;-0.503678482052198;-1.0346599988329448
HELO_2891;18.323236124436846;7.240188635555461;14.225248487708756;29.347354029563693;20.31120920849903;13.794951197783186;0.8530596171960604;0.9762130151240092;1.391334791276241;4.676689478925656;3.0685289486816965;1.8481396535178665;HELO_2891;uncharacterized protein;COG1752;Predicted acylesterase/phospholipase RssA, containd patatin domain;RssA;HELO_RS10440;R;;;;HELO_2891;uncharacterized protein;1.2295874579048296;0.041360836505338394;0.5265075169640046;0.3852317894757471;-0.8443556684290825
HELO_2892;64.76136253583635;28.607398809640745;45.31797713216708;53.93252383456339;45.261783582504556;42.17182859237423;1.7278787702496567;1.6007360601404146;4.060334587197737;3.4613152439717836;2.679521366697058;4.252699534577352;HELO_2892;GAF/sigma-54-interact/HTH domain transcription regulator;COG3604;FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains;FhlA;HELO_RS10445;KT;;;;HELO_2892;GAF/sigma-54-interact/HTH domain transcription regulator;1.1512824445673706;0.10148204607311762;0.09973068779009431;0.6071499900032249;-0.5441324545641457
HELO_2893;9.588031033964164;0.6609490481468699;1.4208014544665346;3.0981038428956595;8.199547404148275;1.2791206102807091;1.156763637490484;0.18918476085911698;0.21019455847412058;0.13805594520542006;0.9744967467728267;0.20756098698399034;hmp;nitric oxide dioxygenase;COG1018;Flavodoxin/ferredoxin--NADP reductase;Fpr;HELO_RS10450;C;hmp; nitric oxide dioxygenase;1.14.12.17;hmp;nitric oxide dioxygenase;2.672354606077217;0.0870074859179728;2.0130856122009266;2.215885149889365;-0.45646945618785173
HELO_2894;48.79360670881056;27.194560805664395;51.474472457736454;59.55102238721533;57.539106956137346;48.24701538476128;3.348268712194113;0.6682459370199596;3.4070068669784965;4.3298828371738916;5.562158774865872;5.602976115458409;HELO_2894;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS10455;K;;hmp;;HELO_2894;AraC family transcription regulator;0.8205436482911805;0.09157946503721348;0.24936444417840864;0.015924225475583142;-0.8046194228155974
HELO_2895;10.809907284279078;124.09992278968052;12.09825573133187;9.10875765945827;10.92947011648878;13.135724563841556;1.5175623479998768;2.5256283741863834;1.2000649007377309;0.5529352718763193;0.25505734112240336;0.9285967746938156;HELO_2895;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG1064;D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family;AdhP;HELO_RS10460;G;;;1.1.1.2;HELO_2895;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);-3.405011355323151;-0.10997113047925033;-0.24481587141264427;-0.25934819555096755;3.1456631597721834
HELO_2896;4.512562483433833;2.0651471903599834;3.569511541827159;4.011860270051964;3.8853856077215876;3.3805515722998867;0.4434530435400841;0.18331910149124073;0.34476581214712515;0.16223417621159777;0.5878252428788636;0.7806603737831393;HELO_2896;ABC-type transport system ATP-binding protein;COG3842;ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component;PotA;HELO_RS10470;E;;;;HELO_2896;ABC-type transport system ATP-binding protein;0.8467667485955932;0.0609274199519807;0.15735990324612414;0.3316105667163214;-0.5151561818792718
HELO_2897;1.9713328680773905;1.0207942994164625;0.98618488633144;1.271218477171421;1.047481122314654;1.2130331191135229;0.3968697470325123;0.2372169049931585;0.15952260923268466;0.5263581174920937;0.5246450954859828;0.23463029169136593;HELO_2897;ABC-type transport system permease protein;COG1177;ABC-type spermidine/putrescine transport system, permease component II;PotC;HELO_RS10475;E;;;;HELO_2897;ABC-type transport system permease protein;0.5561877598737508;-0.1560251178672989;-0.1121748915880334;0.4250851923987857;-0.13110256747496507
HELO_2898;1.4196626984565055;0.6248991718153785;0.6335804354083557;0.9225563686541358;0.334852132154887;0.7225339349286006;0.31104139852388696;0.21839300163179817;0.10480511995260307;0.1510556314955287;0.18466618633720427;0.2540626436319871;HELO_2898;ABC-type transport system permease protein;COG4132;ABC-type uncharacterized transport system, permease component;;HELO_RS10480;R;;;;HELO_2898;ABC-type transport system permease protein;0.5744557506335147;-0.07649491216690663;-0.36785246849499736;0.4902735443436934;-0.08418220628982132
HELO_2899;3.0798540233729654;1.6545069758704998;2.214251774744659;2.6132587441603454;2.76824639860677;1.9441539486634252;0.6464060461598043;0.31887899506172257;0.17744204799965163;0.17771262795180393;0.3492397948761345;0.42076235499029935;HELO_2899;alkaline-phosphatase domain protein;COG1524;c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily;AtaC;HELO_RS10485;T;;;;HELO_2899;alkaline-phosphatase domain protein;0.6200736009113974;0.12662982949124113;0.3560401918449412;0.4706644223569538;-0.14940917855444358
HELO_2900;3.1245625410945634;1.6300511659884196;2.608177173278048;3.2648269912552976;3.1580578735255336;2.239365407779987;0.18054925802487817;0.18825514840862395;0.4586239084200358;0.6878482488845874;1.4453846601448066;0.4919021838183752;HELO_2900;ABC-type transport system periplasmic substrate-binding protein;COG1840;ABC-type Fe3+ transport system, periplasmic component;AfuA;HELO_RS10490;P;;;;HELO_2900;ABC-type transport system periplasmic substrate-binding protein;0.6491502459935938;0.1555589647769342;0.36019862175528927;0.34852989591541905;-0.3006203500781748
HELO_2901;8.806481151359884;2.8039609616353833;8.531409436866914;8.565981527341004;9.424983566217774;8.15909209908669;0.23001419215940494;0.16197898537838187;0.6018350875615404;0.8480425332533598;1.2822519799453291;1.197624740756363;HELO_2901;HutC family transcription regulator;COG2188;DNA-binding transcriptional regulator, GntR family;MngR;HELO_RS10495;K;;;;HELO_2901;HutC family transcription regulator;1.3662331081222263;0.05748496803306313;0.18676860698408015;0.09853095132423029;-1.267702156797996
HELO_2902;22.96852864023616;11.525158160125239;28.343916534774774;24.221676198626625;30.05148905931766;26.800994587130116;1.1347024624380262;0.8398986698011046;2.279973663571362;1.5649682482100151;4.142866085161697;3.1446625127184826;HELO_2902;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS10500;K;;;;HELO_2902;LysR family transcription regulator;0.9363125277459861;0.07792494385274384;0.15952595722887608;-0.2139951478646669;-1.150307675610653
HELO_2903;5.4906778529801885;2.381564756756134;4.792534977383823;4.680823991605457;8.432232292692332;5.895806129955271;1.2857030521549437;0.2526689080545404;0.2486003746503456;0.21164542274625558;0.2379659356363301;0.7025419526557296;HELO_2903;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS10505;I;;;1.1.1.100;HELO_2903;probable oxidoreductase (short-chain dehydrogenase family);0.9406781721890929;-0.2515243641645615;0.4518800340011069;-0.08735006105074827;-1.0280282332398412
HELO_2904;112.94102027720162;74.0717825278113;322.0434446087448;346.02654021387343;244.68032606259945;328.29650152961875;6.412718448247585;7.941137039050706;16.180731068611262;26.556474966769525;34.51425754039726;48.798836892345804;HELO_2904;uncharacterized protein;;;;;;;;;HELO_2904;uncharacterized protein;0.6019445855776429;-0.027658985410280224;-0.42260485256875757;-1.5310999548211468;-2.1330445403987897
HELO_2905;125.16700883146875;84.40575634396673;146.88660706865267;192.26016917758318;105.89480314699988;132.17067203082476;2.9918673125046196;3.407433019115296;14.397241986325188;1.9533218249470758;22.71746444974954;16.68806940237282;HELO_2905;uncharacterized protein;;;;;;;;;HELO_2905;uncharacterized protein;0.5629294962692093;0.15121500985256375;-0.3170846789579871;-0.07794168283083192;-0.6408711791000412
HELO_2906;141.04307031213702;82.00210965637542;91.71116963591454;107.2138525542302;63.876034354223236;81.84223007673461;3.8036604252400257;3.592539704951269;18.560444412460175;4.80424718173677;5.439443478019716;17.325164411163534;HELO_2906;DUF4123 domain protein;;;;;;;;;HELO_2906;DUF4123 domain protein;0.7751085393068653;0.16237677121491245;-0.3526807554702529;0.7778901542659673;0.002781614959102008
HELO_2907;138.02896745002224;72.79116033254002;229.7987830364882;279.6966462850862;212.83878346969206;224.76201168263898;5.468430977146064;3.512556844993652;12.197209338683392;14.189312923256734;61.93368269366041;22.22450481231382;vgr1;T6SS-related Vgr family protein;COG3501;Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly;VgrG;HELO_RS10525;UXR;vgr1; T6SS-related Vgr family protein;;vgr1;T6SS-related Vgr family protein;0.9138656007912278;0.03183286848052269;-0.07827921321747766;-0.6994172407176364;-1.6132828415088643
HELO_2908;350.7603792830919;193.4606839929553;197.21934527865133;215.90983555492048;176.01748213593962;229.91912548297455;32.41799043963028;17.936322811492047;53.08424758657541;46.84618580373988;0.8389403162910993;64.1888978170126;HELO_2908;T6SS cluster PAAR domain protein;COG4104;Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion;PAAR;HELO_RS10530;U;;vgr1;;HELO_2908;T6SS cluster PAAR domain protein;0.8551144922282115;-0.22028989715148128;-0.38349581981305025;0.6072053264212922;-0.24790916580691924
HELO_2909;283.25755990077283;168.00828896419918;264.3943137374652;310.21866810119786;230.63529696480782;267.6043835990343;11.621622605210389;3.4081434305898113;26.740373425918804;18.12558289533945;29.34837317303362;57.60996325408921;HELO_2909;GNAT family acetyltransferase;;;;;;;;;HELO_2909;GNAT family acetyltransferase;0.7501047136456718;-0.01734538934031704;-0.2136277393040409;0.0817158688536157;-0.6683888447920561
HELO_2910;205.58700804250498;129.08310951344131;294.7322146014384;367.28841555932763;260.16742314483236;291.9867726162181;8.71753989184419;5.42082336510565;16.84975973920502;14.313063743020448;61.90385543223995;45.74261210906176;vasK;T6SS cluster protein VasK;COG3523;Type VI protein secretion system component VasK;IcmF;HELO_RS10540;U;vasK; T6SS cluster protein VasK;;vasK;T6SS cluster protein VasK;0.667315878860431;0.013455873977900268;-0.16586058042202545;-0.5040860051523328;-1.1714018840127638
HELO_2911;227.90954897407423;147.31320758274222;321.6396852949768;438.06916185904356;278.1901990888805;308.5072230099861;4.8692289350490725;1.920636153536431;12.785200603244776;6.81156946830983;61.572579294628234;41.18206452833846;vasJ;T6SS cluster protein VasJ;COG3515;Type VI protein secretion system component TssA1/VasJ/EvfE, contains ImpA_N domain;TssA1;HELO_RS10545;U;vasJ; T6SS cluster protein VasJ;;vasJ;T6SS cluster protein VasJ;0.6261305679063423;0.05995082544953512;-0.14872478125130328;-0.4351954319430176;-1.0613259998493598
HELO_2912;179.167910409476;118.80526938002197;170.6678540561377;235.58996183527486;143.04249143890925;161.61016946634606;9.268546218432345;2.694933804275764;13.497554619017329;20.871610009932724;27.010767777132475;23.067512547447897;vasI;T6SS cluster protein VasI;;;;;;;;;vasI;T6SS cluster protein VasI;0.5886507131512966;0.07820242557769852;-0.17492302633042822;0.14792459170560246;-0.4407261214456941
HELO_2913;246.3090579288213;164.77563455428114;323.0931486841298;494.68431534041355;258.22029956956936;292.2314830420584;3.709991920844855;4.4249800978301;7.236756055272824;30.906585062049924;58.11326592279232;54.441232568812126;vasH;GAF/sigma-54-interact/HTH domain transcription regulator VasH;COG3829;RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains;RocR;HELO_RS10555;KT;vasH; GAF/sigma-54-interact/HTH domain transcription regulator VasH;;vasH;GAF/sigma-54-interact/HTH domain transcription regulator VasH;0.5770831034347488;0.14436851452357047;-0.17786130769015784;-0.2457249271707429;-0.8228080306054917
HELO_2914;326.55317102402574;281.36296579353615;573.865116725712;741.0913270610887;408.3262878002069;510.7497687831724;16.172628841500725;12.67931215633639;20.60806837535675;14.935561489960305;87.01184973634756;75.880230758229;clpV;T6SS cluster protein ClpV;COG0542;ATP-dependent Clp protease, ATP-binding subunit ClpA;ClpA;HELO_RS10560;O;clpV; T6SS cluster protein ClpV;;clpV;T6SS cluster protein ClpV;0.21417823554812365;0.16778494410454847;-0.32218722273174727;-0.6437094300748107;-0.8578876656229344
HELO_2915;218.369498215824;196.62980769092283;299.98258357413914;332.5934989846159;266.5781251555584;307.2097825932123;2.641362874645123;2.1241503978148404;4.287227423388949;25.1741215675824;42.09707332745416;42.23525148157129;vasF;T6SS cluster protein VasF;COG3455;Type VI protein secretion system component TssL/VasF/DotU;DotU;HELO_RS10565;U;vasF; T6SS cluster protein VasF;;vasF;T6SS cluster protein VasF;0.15056238400585364;-0.03423264626631273;-0.20395247510227676;-0.49054971069091824;-0.6411120946967719
HELO_2916;250.3584891181173;233.46115956716199;460.95740690495086;498.40885702225387;421.83063989524527;481.5137504146939;13.29200739951358;4.354846398725533;8.827937968987477;25.42769636173648;68.3458521183929;68.93932096843513;vasE;T6SS cluster protein VasE;COG3522;Predicted component of the type VI protein secretion system;;HELO_RS10570;U;vasE; T6SS cluster protein VasE;;vasE;T6SS cluster protein VasE;0.10039746577347852;-0.06281021675845011;-0.1904901324996171;-0.9408236421799137;-1.0412211079533922
HELO_2917;208.54042731175355;192.3550105074048;270.9122332411052;311.7684429839672;211.14878228422478;272.41901471032736;10.579861542426208;13.458452577584547;18.114976824178072;26.487811791363107;24.201903977658656;28.138668401827765;vasD;T6SS cluster protein VasD;COG3521;Predicted component of the type VI protein secretion system;;HELO_RS10575;U;vasD; T6SS cluster protein VasD;;vasD;T6SS cluster protein VasD;0.11597646439463105;-0.007972518331037293;-0.36603717981787653;-0.38388496292960905;-0.4998614273242401
HELO_2918;265.70975383126273;208.78172753957415;433.90480902541714;471.3380930140299;372.37038123528214;419.59750972327043;8.927676272073901;4.140805735899133;20.161622069589527;15.220903670793962;66.13851208677674;39.040319356886975;vasC;T6SS cluster protein VasC;COG3456;Predicted component of the type VI protein secretion system, contains a FHA domain;;HELO_RS10580;TU;vasC; T6SS cluster protein VasC;;vasC;T6SS cluster protein VasC;0.3463815651898612;0.048259353531936;-0.17183282233597907;-0.6571697215822372;-1.0035512867720984
HELO_2919;159.4468892383159;151.2346308663193;173.58172948372257;192.5733686193047;121.05344483163032;172.1977737946636;2.9886117775952976;6.708409158076773;14.308393157177045;3.674845037928167;18.375471101524568;23.038626892950116;vasB;T6SS cluster protein VasB;COG3520;Predicted component of the type VI protein secretion system;;HELO_RS10585;U;vasB; T6SS cluster protein VasB;;vasB;T6SS cluster protein VasB;0.07579923327286053;0.011482197944367556;-0.5049073721767074;-0.11032456767554066;-0.1861238009484012
HELO_2920;234.21052815543126;251.1927925508322;359.1959826137818;379.4058467306818;239.13015095919363;353.7503238588394;8.54650796287816;8.25166857147441;9.336038269630967;13.54062889495994;36.976466336668935;49.09915787443982;vasA;T6SS cluster protein VasA;COG3519;Type VI protein secretion system component VasA;VasA;HELO_RS10590;U;vasA; T6SS cluster protein VasA;;vasA;T6SS cluster protein VasA;-0.10057440783399496;0.021978089121505562;-0.5629874403148731;-0.5928513638919028;-0.4922769560579079
HELO_2921;358.4691504917314;266.71689706246906;189.50988180025072;236.212323413459;150.39801918037736;193.70474069436193;5.036138103512156;10.399134027186514;25.32096892467214;31.588949198877206;22.09591905024505;40.381232028122334;sciD;T6SS cluster protein SciD;COG3518;Predicted component of the type VI protein secretion system;;HELO_RS10595;U;sciD; T6SS cluster protein SciD;;sciD;T6SS cluster protein SciD;0.4251597662819204;-0.03142217874742759;-0.3629416814857338;0.8845799530296805;0.4594201867477601
HELO_2922;657.4334402537612;760.0922851040519;1072.4337704307475;1341.5354531082992;909.5867338166976;1045.5041195216963;30.57485461171024;37.302857821001204;17.257791311843636;67.45635041482322;133.3218686544708;101.00827678921483;vipB;T6SS cluster protein VipB;COG3517;Predicted component TssB of the type VI protein secretion system, VipA/VipB/TssB family;;HELO_RS10600;U;vipB; T6SS cluster protein VipB;;vipB;T6SS cluster protein VipB;-0.209033787521669;0.03665519068194101;-0.20070964447214656;-0.668468476965657;-0.459434689443988
HELO_2923;644.6846653898514;526.3623008248592;1136.4932516894794;1303.948606708034;806.3587697845663;1083.4793759339263;21.09393431922064;35.40808926031386;105.30713760441344;44.759464739541635;93.49900138162349;146.32630090782678;vipA;T6SS cluster protein VipA;COG3516;Predicted component TssA of the type VI protein secretion system;TssB;HELO_RS10605;U;vipA; T6SS cluster protein VipA;;vipA;T6SS cluster protein VipA;0.2920353224096939;0.06885536953587668;-0.4257207986152327;-0.7481009473526008;-1.0401362697622947
HELO_2924;46.41452705038847;33.17349690512339;34.50048212381774;41.89698026248094;23.427928057451922;28.958146505895055;1.6529780512831382;1.41686062182769;4.331262685802968;2.822989903057544;4.269147229763395;7.872907236657084;HELO_2924;uncharacterized protein;;;;;;;;;HELO_2924;uncharacterized protein;0.47245126206625;0.24489024985098506;-0.2944168663789437;0.6623807776593047;0.1899295155930547
HELO_2925;183.9367093859021;121.56755503328888;156.95829936014027;224.02106557457645;105.97882803374777;144.0631561670294;14.680562478839288;1.2954844015794809;4.667093110376062;6.23283882986319;14.84340941187788;13.787500724906238;HELO_2925;TPR domain protein;COG0790;TPR repeat;TPR;HELO_RS10615;R;;;;HELO_2925;TPR domain protein;0.5934544913595845;0.12286259702892277;-0.43935583937418254;0.3503504804802908;-0.24310401087929367
HELO_2926;58.76110631301748;39.882247835568215;91.71790055916857;147.32445278103228;49.09735277973548;75.41104622766797;2.2725869584699674;2.1696689865533476;6.8207123757224934;4.667585444125025;12.283209947581023;10.538852147082384;HELO_2926;uncharacterized protein;;;;;;;;;HELO_2926;uncharacterized protein;0.5477323335146167;0.27906668531988466;-0.6090468427570803;-0.35457435807577564;-0.9023066915903923
HELO_2927;62.61219993827465;45.39415417637347;68.29158453465257;99.33990294924706;38.816188075508926;65.79164796218406;3.6831047052953427;1.3946821100709441;7.020327313014971;2.1058068109623367;6.330742676951199;14.856970358351083;HELO_2927;DUF4123 domain protein;;;;;;;;;HELO_2927;DUF4123 domain protein;0.45536044871066306;0.05301243710824188;-0.7463126036811678;-0.07036422957206678;-0.5257246782827298
HELO_2928;48.37275310825823;40.538841999091936;118.75066636733884;159.96172077779156;73.1754286350969;113.60294643211252;2.1424225194722295;1.1412577607650742;5.613100026060411;4.904220769083922;18.51698490972885;11.790773300408317;vgr2;T6SS-related Vgr family protein;COG3501;Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly;VgrG;HELO_RS10630;UXR;vgr2; T6SS-related Vgr family protein;;vgr2;T6SS-related Vgr family protein;0.24925409649049346;0.06338954789833817;-0.6276308724433806;-1.2148571365884138;-1.4641112330789072
HELO_2929;61.03531723073575;104.82653758337192;52.763166662029846;76.33115261595675;28.346627447913637;38.181403705827485;2.2292309998954;14.141502753659577;6.994767130354286;11.719496781733925;14.48196270047697;6.006263158283898;hcp1;T6SS-related Hcp family protein;COG3157;Type VI protein secretion system component Hcp (secreted cytotoxin);Hcp;HELO_RS10635;U;hcp1; T6SS-related Hcp family protein;;hcp1;T6SS-related Hcp family protein;-0.7705397571423553;0.4564490314052234;-0.41697436776505814;0.6629207036125582;1.4334604607549135
HELO_2930;42.44964023138146;10.886013601418574;31.095816099325223;30.418022960765;28.80772021159069;29.580672608707562;4.993468569402893;0.3814259023096096;5.012144069851404;5.2996240756362525;1.6006471421165516;4.121641308784744;HELO_2930;biotin/lipoate--protein ligase domain protein;COG0095;Lipoate-protein ligase A;LplA;HELO_RS10640;H;;hcp1;;HELO_2930;biotin/lipoate--protein ligase domain protein;1.8700792944195292;0.06976510631621036;-0.036934100819260074;0.5067240928853227;-1.3633552015342065
HELO_2931;7.153480719134137;1.817232155753352;9.562570349019984;21.22242984952506;12.89978175270584;12.348759380207133;0.2779788907247777;0.3779993505959067;0.342350185055023;2.3581515568425124;0.28611536234151924;1.7137987352549546;ivd;isovaleryl-CoA dehydrogenase;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS10645;I;ivd; isovaleryl-CoA dehydrogenase;1.3.8.4;ivd;isovaleryl-CoA dehydrogenase;1.5331376222529218;-0.33774471547864815;0.058356565095040835;-0.7112176834170283;-2.2443553056699503
HELO_2932;6.082758656415348;1.671216855251384;7.887680317697772;12.179031249415326;13.810404458563623;8.574383828313842;0.2293525758445978;0.35843586202613553;0.887855655123986;1.542761176402805;1.3719746008333251;1.5951443276833803;mccB;methylcrotonoyl-CoA carboxylase beta subunit;COG4799;Acetyl-CoA carboxylase, carboxyltransferase component;MmdA;HELO_RS10650;I;mccB; methylcrotonoyl-CoA carboxylase beta subunit;6.4.1.4;mccB;methylcrotonoyl-CoA carboxylase beta subunit;1.4068142817007483;-0.10737271839855289;0.6293594911854581;-0.43486825996489653;-1.8416825416656448
HELO_2933;5.493465536877204;2.7771320989753066;6.9900188944377275;12.414115565889466;11.570611424402797;7.337377037113181;0.010749680006229155;0.1438547328028629;1.1788175628257334;0.635162029096346;0.4476460433372161;0.050635689760950266;HELO_2933;probable enoyl-CoA hydratase;COG1024;Enoyl-CoA hydratase/carnithine racemase;CaiD;HELO_RS10655;I;;mccB;4.2.1.18;HELO_2933;probable enoyl-CoA hydratase;0.7816974038541282;-0.06139466424753115;0.5923893388505515;-0.36060493462734655;-1.1423023384814748
HELO_2934;9.252491353247414;4.458821403224719;12.80875029681595;18.743118404401287;23.265708390597638;14.694897346190961;0.8800844387487631;0.23097484582027747;0.6701467564175823;2.937549156339553;1.0688795201819208;1.7423159737398008;mccA;methylcrotonoyl-CoA carboxylase alpha subunit;COG4770;Acetyl/propionyl-CoA carboxylase, alpha subunit;PccA;HELO_RS10660;I;mccA; methylcrotonoyl-CoA carboxylase alpha subunit;6.4.1.4;mccA;methylcrotonoyl-CoA carboxylase alpha subunit;0.9093131247453807;-0.18471283245764347;0.6286233845371512;-0.6143210659568519;-1.5236341907022326
HELO_2935;20.647084978752826;7.476534900731941;16.03465480551874;18.036848772983863;22.99337708655261;16.861019325420315;0.999549990376996;0.5657444545714182;2.843644477376644;1.9124946428769052;1.8700848672111834;1.2564063782434223;hmgL1;hydroxymethylglutaryl-CoA lyase;COG0119;Isopropylmalate/homocitrate/citramalate synthases;LeuA;HELO_RS10665;E;hmgL1; hydroxymethylglutaryl-CoA lyase;4.1.3.4;hmgL1;hydroxymethylglutaryl-CoA lyase;1.3526262279723436;-0.06834170457674027;0.42582181520010387;0.2773583458893878;-1.0752678820829558
HELO_2936;17.07305377601838;16.667864775822633;125.00549568770236;78.79653358736283;82.52363495202907;131.5738077488672;1.7393128086566563;1.2278573174931195;8.758418953168297;1.4347710938815046;6.535716532041975;10.716827402073733;HELO_2936;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS10675;G;;hmgL1;;HELO_2936;TRAP transporter substrate-binding protein;0.032712601147952824;-0.07330911645774218;-0.6665393696843402;-2.8748835723507193;-2.907596173498672
HELO_2937;13.576651758151987;16.282586813749802;31.736405527853606;25.941269127876723;26.170928827293398;32.09514539490019;2.204423918102572;1.0632202853453072;1.0734854115283385;2.001396049623253;1.9337796528520477;2.3543316210228973;HELO_2937;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS10680;K;;;;HELO_2937;TetR family transcription regulator;-0.2456598004391064;-0.015723686985655405;-0.2845557245715433;-1.1829602367669616;-0.9373004363278552
HELO_2938;8.71495756449068;7.078258490556903;10.010363346356199;8.198567594945867;10.263901939558291;11.21402526263762;1.3092650669963333;0.9749924155649341;1.4375312441885935;1.2330881431465426;1.8806994056028996;1.2601872162123338;HELO_2938;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS10685;G;;;;HELO_2938;TRAP transporter small transmembrane protein;0.26616338347552126;-0.14967665507038186;-0.11683205483156511;-0.3302591351069055;-0.5964225185824268
HELO_2939;7.396106026308785;6.139315301627609;13.015979918757168;9.543089788471322;12.060718780192502;13.869535024679571;0.5888609658591304;0.4338511372983301;0.7526099305252086;0.32940830208711386;0.10581256532437862;1.6688760794712993;HELO_2939;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS10690;G;;;;HELO_2939;TRAP transporter large transmembrane protein;0.23393466639815985;-0.08528692149291794;-0.18712523856853247;-0.8245672442813401;-1.0585019106795
HELO_2940;34.3508500971597;31.45687583763558;79.78730904519439;54.29911407940916;75.97765777409961;78.0411100839885;2.1009847129997343;2.098700941712077;5.649011939375883;1.4071597872851551;10.425911750477155;7.036736576696933;HELO_2940;amidohydrolase domain protein;COG1228;Imidazolonepropionase or related amidohydrolase;HutI;HELO_RS10695;Q;;;;HELO_2940;amidohydrolase domain protein;0.12322076975077678;0.03152546761423558;-0.03816343439922765;-1.1608583002707116;-1.2840790700214884
HELO_2941;192.52665069845872;187.1843354551776;212.98900105106762;260.48303075752943;231.86759113995913;204.9599035550967;4.592330431405632;4.355632295389738;16.28508167581612;2.8005507902198983;20.054816310650935;13.20384244325621;HELO_2941;ribosomal protein S12 beta-methylthiolation protein YcaO;COG1944;Ribosomal protein S12 methylthiotransferase accessory factor YcaO;YcaO;HELO_RS10700;J;;;;HELO_2941;ribosomal protein S12 beta-methylthiolation protein YcaO;0.04038571214359621;0.05517314490798064;0.17714636977693488;-0.08983124502316198;-0.13021695716675818
HELO_2942;192.9785097748888;89.93234533676876;77.44527125046766;73.52624937611705;98.05588058140192;78.67688886583333;6.512923499785432;6.806787158819828;4.055883998810818;7.263503983877984;11.40779211714689;12.59061117958297;HELO_2942;tautomerase domain protein;;;;;;;;;HELO_2942;tautomerase domain protein;1.0930313613651323;-0.022474832865002625;0.31408130936667256;1.2836636090719376;0.1906322477068052
HELO_2943;105.90943507513914;37.01822975560782;100.17828230240758;87.228160289677;95.94377499791513;91.55582948927525;3.6126238459846696;2.835442501574531;6.938520961731362;3.554357292849366;18.34915125710291;17.670231025424922;dhaK;dihydroxyacetone kinase;COG2376;Dihydroxyacetone kinase;DAK1;HELO_RS10750;G;dhaK; dihydroxyacetone kinase;;dhaK;dihydroxyacetone kinase;1.4916259184041767;0.12850388787848654;0.06682440332396133;0.20799341675821115;-1.2836325016459655
HELO_2944;164.2719432501024;51.50540149050074;96.81645717320998;74.06274399201179;95.43624777992437;88.37860975906443;7.9543506115731555;5.69947364402862;14.559247018006543;2.8584543798495448;17.12775352281087;10.877848608209895;HELO_2944;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS10755;J;;dhaK;2.3.1.-;HELO_2944;GNAT family acetyltransferase;1.6543040791879848;0.1301476079798647;0.10964591399309409;0.8868403222945922;-0.7674637568933926
HELO_2945;26.88462193951207;11.122265685424345;17.34008150441477;14.920462422702144;21.60402450073588;18.251186855890023;1.2641105177637306;0.24298371340356056;1.1936468084688097;0.5795275487949608;1.2607458570480474;1.3666219464997875;HELO_2945;SSS family transport protein;COG0591;Na+/proline symporter;PutP;HELO_RS10775;E;;;;HELO_2945;SSS family transport protein;1.2018103432529372;-0.06994734184406326;0.2316322658402532;0.5345223187972543;-0.6672880244556829
HELO_2946;14.819587281465111;5.573369372744801;5.409109816710106;4.075453115610102;4.891861811381207;4.982598688020974;2.571338258773608;1.795401311331759;2.137623748943501;1.7046875575565827;1.280910656660082;1.3970159715684671;HELO_2946;uncharacterized protein;;;;;;;;;HELO_2946;uncharacterized protein;1.2670070009176748;0.0993516994519803;-0.02204869685122457;1.4028677661636073;0.1358607652459325
HELO_2947;32.114573031172604;15.91928917793797;20.989430920126217;25.624942159664545;22.12194042819662;20.751631623455463;2.146506011760408;1.5839571148434037;1.3650958027291311;2.82269126288311;1.8904590853299363;2.3059209753476813;HELO_2947;amidase domain protein;COG0154;Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase;GatA;HELO_RS10785;J;;;3.5.1.4;HELO_2947;amidase domain protein;0.9687972982282833;0.01568664435945699;0.08813885226630358;0.6063426328958439;-0.3624546653324394
HELO_2948;52.99205387848428;28.838811152551937;25.440100488437285;27.21085414802218;23.840201307458695;26.300931020522984;2.900349216379698;1.217305194182515;1.5130814078173427;3.0020150033789217;1.1171817460300981;3.422493808732108;HELO_2948;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS10790;K;;;;HELO_2948;LysR family transcription regulator;0.8555570420835652;-0.0462224910176241;-0.1362732856411828;0.9837969475141071;0.12823990543054187
HELO_2949;60.78761470257134;37.22813364727033;45.105233371616286;61.45336122446875;45.809937374124424;50.91427968389852;5.914846944327628;1.6080088011125757;3.0075715010560793;3.573062383575678;2.1079815316214727;2.015495971547529;HELO_2949;GNAT family acetyltransferase;COG1246;N-acetylglutamate synthase or related acetyltransferase, GNAT family;ArgA;HELO_RS10795;E;;;;HELO_2949;GNAT family acetyltransferase;0.6926829121525522;-0.17120090560002943;-0.14931658991307462;0.25118625476996037;-0.4414966573825918
HELO_2950;20.390213937774046;5.104954565445522;11.395094620636149;15.134696283356455;13.170834760550163;10.0933195663998;1.2249265529434386;0.785941194738425;1.803387501473159;1.5171589972863244;1.0603470208837973;0.11464091069080533;HELO_2950;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS10800;K;;;;HELO_2950;PfpI/HTH domain protein (homolog to transcription regulator CdhR);1.8088984484505457;0.16007814223306172;0.3532336031548282;0.9472597695706648;-0.8616386788798809
HELO_2951;2.0705251861416434;0.9444512090365964;1.1566069625551743;1.8756044273337558;1.7776351088136362;0.8677523039629257;0.13853419369854647;0.03932170242768219;0.1654030161805536;0.24075483745236606;0.5623586324633598;0.4130007461467789;HELO_2951;probable S-adenosylmethionine-dependent methyltransferase;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS10805;H;;;;HELO_2951;probable S-adenosylmethionine-dependent methyltransferase;0.6591224023782367;0.20746013048562328;0.5725539468288868;0.7171822953216481;0.058059892943411406
HELO_2952;6.908517128213405;2.70030507349961;3.3954206601690964;3.2681293034217465;4.169814851393123;3.2526461356763097;0.356600839809233;0.9294374958351148;0.24066681973098952;0.22567162851716968;0.7062778628372481;0.46210394205800753;HELO_2952;uncharacterized protein;COG3865;Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase;;HELO_RS10810;R;;;;HELO_2952;uncharacterized protein;1.0957629908486637;0.04764043118713479;0.2817518009143649;0.8950463974590965;-0.20071659338956716
HELO_2953;7.030576017077941;5.652506413161354;10.61698562562478;10.043154274356462;7.691857532526504;9.887415925098699;0.41626044788102345;1.07474341011541;1.2848860452367472;0.8162924829528074;1.3864444079225724;1.6089137495244699;HELO_2953;DUF1428 domain protein;COG5507;Uncharacterized conserved protein YbaA, DUF1428 family;YbaA;HELO_RS10815;S;;;;HELO_2953;DUF1428 domain protein;0.2716054770321339;0.09357418884952295;-0.3249251453366062;-0.4390861998920794;-0.7106916769242133
HELO_2954;79.56794619428062;20.257581719034576;41.598352055981685;53.46534994396072;51.653518174966344;41.206745506442395;3.0553933571415484;1.8137307475509536;3.2616149034677155;4.051893808459757;5.889823161561918;2.5661080318487186;HELO_2954;cation diffusion facilitator family transport protein;COG3965;Predicted Co/Zn/Cd cation transporter, cation efflux family;;HELO_RS10820;P;;;;HELO_2954;cation diffusion facilitator family transport protein;1.9222284954316944;0.013324030252226393;0.31905634199271216;0.9327323896798925;-0.9894961057518019
HELO_2955;72.55436762035141;17.046639736203232;27.184345315670118;36.09171328904272;42.45773052746001;26.51768626277469;0.7188628227145916;1.3794978018236073;4.080054799779549;2.5453370660129697;4.85474013737268;3.4911227517952472;HELO_2955;RutC family protein;COG0251;Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family;RidA;HELO_RS10825;V;;;3.5.99.10;HELO_2955;RutC family protein;2.0270807765674093;0.034534885297853535;0.6592536645940967;1.4184518397994355;-0.6086289367679738
HELO_2956;4.940123613491075;6.953444696752761;31.403766640908717;14.315853418910512;8.999881845865271;29.481527771335077;0.15155201525507972;0.7732575706699115;3.6100763208793314;0.6151731648053159;1.1652678969780372;4.529411248154466;HELO_2956;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS10830;E;;;;HELO_2956;LysE family transport protein;-0.42108688412203366;0.08822630865661729;-1.6079522604169338;-2.3593703554598413;-1.9382834713378077
HELO_2957;36.96759419205781;35.8016249740437;63.45001865286239;46.954316469138604;49.29078560167961;61.000055282021826;1.2346628377661226;1.5875867379861461;2.957060245958012;1.3244343259963878;3.7184097126035756;7.178897854254363;HELO_2957;YjiR family protein;COG1167;DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain;ARO8;HELO_RS10835;KE;;;;HELO_2957;YjiR family protein;0.044999115989776683;0.055911274254420995;-0.3019754116722444;-0.7075009160603996;-0.7525000320501762
HELO_2958;6.625599209549787;4.332775759543339;5.651199044536562;6.249973141677477;6.568856768448325;5.280064657663554;0.3985936120650421;0.5543611631727687;0.6011174924491296;0.5407688539007814;0.5260663550967117;0.7085136452639738;clcB1;ClC-type chloride channel ClcB;COG0517;CBS domain;CBS;HELO_RS10840;T;clcB1; ClC-type chloride channel ClcB;;clcB1;ClC-type chloride channel ClcB;0.5159640423771101;0.08283503307861428;0.26929599326834275;0.2800712943456056;-0.2358927480315045
HELO_2959;1.864005471991341;1.174902298395591;1.1889125573919268;1.1213310062063802;0.8494105167159839;0.9473968537768885;0.0831547688361009;0.04840043303262748;0.1145692161031564;0.33092559302079505;0.2326265187412814;0.23259196499650447;HELO_2959;ABC-type transport system periplasmic substrate-binding protein;COG0687;Spermidine/putrescine-binding periplasmic protein;PotD;HELO_RS10845;E;;clcB1;;HELO_2959;ABC-type transport system periplasmic substrate-binding protein;0.39708365578565585;0.16866740670745073;-0.07448141853041823;0.5564873328015916;0.15940367701593572
HELO_2960;53.66921182607158;25.46171960074919;31.917473933250808;38.50069295552058;42.73403872807034;31.197224525082504;1.7692390748226654;0.39617076872603213;3.0246109650958375;3.134828269751763;1.374532153207524;1.6043262580506625;kduI;4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase;COG3717;5-keto 4-deoxyuronate isomerase;KduI;HELO_RS10850;G;kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase;5.3.1.17;kduI;4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase;1.0468217587129995;0.031917298411032746;0.44182025375199085;0.7637922460803521;-0.2830295126326474
HELO_2961;50.27518611736314;23.775067694327362;22.97524978556261;34.447461003405685;26.868342452856826;18.299365797878608;4.136204404364463;1.4589875310807505;3.666708157686581;4.331742948029647;1.3339476853126073;2.511397525353753;kduD;2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS10855;I;kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase;1.1.1.127;kduD;2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase;1.0493718239973946;0.3129924065579406;0.5300737572478118;1.409707383924994;0.36033555992759947
HELO_2962;208.47608681035095;356.8385706341217;309.11630297177913;315.487371542807;366.29219512058336;309.5897416746104;10.28554823338079;20.56555261835061;14.816409864046834;15.663696633508215;45.7352264007002;35.20775354854502;kdgR;IclR family transcription regulator KdgR;COG1414;DNA-binding transcriptional regulator, IclR family;IclR;HELO_RS10860;K;kdgR; IclR family transcription regulator KdgR;;kdgR;IclR family transcription regulator KdgR;-0.7725233413093964;-0.002200809246460267;0.24191805903613606;-0.5682246210089765;0.20429872030041984
HELO_2963;5.86245021796745;3.0613204612089593;4.556445006931523;3.2208764162148356;7.513471234245863;4.37514504650528;0.8639035111322189;0.06550920826472503;0.7230101509463277;0.3327182632075992;1.1290432511559505;0.7128326395031654;HELO_2963;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS10875;G;;;;HELO_2963;TRAP transporter large transmembrane protein;0.7567749098922709;0.047858461246292894;0.663443802246193;0.3524200925893535;-0.40435481730291745
HELO_2964;14.813371734890424;10.586065057207398;15.825679654477959;9.824611153549922;32.203884416497104;15.366486050656325;1.1769325158100816;1.5108329364824913;3.365646594625052;0.661744349485776;1.8004330801803652;1.1580341403218448;HELO_2964;glycosyl hydrolase family 88 protein;COG4225;Rhamnogalacturonyl hydrolase YesR;YesR;HELO_RS10880;G;;;3.2.1.172;HELO_2964;glycosyl hydrolase family 88 protein;0.44875434158239624;0.03992017933890324;1.0206074250115371;-0.04959959008251591;-0.49835393166491215
HELO_2965;27.439067988107936;24.357418686332796;39.21017987980027;20.036144516189633;67.14632847031314;41.620988800489364;1.4459565885452301;2.9003496000676514;2.3383711785108763;0.291555131320453;7.459912256543667;4.5079191913636185;HELO_2965;xylose isomerase domain protein;COG1082;Sugar phosphate isomerase/epimerase;YcjR;HELO_RS10890;G;;;;HELO_2965;xylose isomerase domain protein;0.16546629471963126;-0.08400327378225914;0.6770718670175109;-0.5836898784280207;-0.7491561731476519
HELO_2966;46.802552312360156;20.872128219588706;41.82593811734483;87.15819619739516;55.55025300794299;42.000960381283754;1.9742544983860268;2.446186948307763;3.535689919422932;1.2688417866846382;7.407530904489214;4.646473925120018;HELO_2966;UPF0047 family protein;COG0432;Thiamin phosphate synthase YjbQ, UPF0047 family;YjbQ;HELO_RS10895;H;;;;HELO_2966;UPF0047 family protein;1.1279940442967344;-0.005884031851611127;0.39516459764805756;0.15271876854473732;-0.9752752757519971
HELO_2967;76.48249764453418;32.89221927982986;40.27596384218422;53.10507646282506;48.757543162472246;40.038700817825536;1.2273139059244413;0.8551592343469574;1.2431835844811574;3.133971329167901;5.137025805200297;4.93612407812262;HELO_2967;kinase domain protein;COG0661;Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family;AarF;HELO_RS10900;TH;;;;HELO_2967;kinase domain protein;1.1929163515719017;0.008316844586684802;0.27793019288651166;0.9168854003279518;-0.27603095124394983
HELO_2968;14.582045163165596;6.230456253724223;18.523604808619183;26.70304136391843;18.06853341676884;13.425944266887752;0.4214576785951426;0.8360953206776298;0.7013832718932007;7.536311363231853;2.648720742470441;1.6937260978047957;pilA;fimbrial protein PilA;COG4969;Type IV pilus assembly protein, major pilin PilA;PilA;HELO_RS10905;NW;pilA; fimbrial protein PilA;;pilA;fimbrial protein PilA;1.1077260097790171;0.43655369927174315;0.4025281333166011;0.1112188461427337;-0.9965071636362834
HELO_2969;1.66770917670242;0.41438930212179725;0.4041419000867233;0.6794151374823766;0.546034050741549;0.36854651005358746;0.1479351896217964;0.06068678277905492;0.08508706720630384;0.0960696298802552;0.09679003115750963;0.16695140911393636;pilB;type 4 fimbrial assembly protein PilB;COG2804;Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB;PulE;HELO_RS10910;NWU;pilB; type 4 fimbrial assembly protein PilB;;pilB;type 4 fimbrial assembly protein PilB;0.9154221301706713;0.03704427368112412;0.17592762882908236;0.9629569325549039;0.04753480238423252
HELO_2970;1.2933784909250832;0.45009086621290956;0.8462607875767477;1.0334111544995277;0.7406883665263142;0.7216470551764852;0.1860686382549392;0.08132597724799405;0.16353951383050327;0.24498476195004268;0.28115989115944146;0.024974461998506503;pilC;type 4 fimbrial assembly protein PilC;COG1459;Type II secretory pathway, component PulF;PulF;HELO_RS10915;NWU;pilC; type 4 fimbrial assembly protein PilC;;pilC;type 4 fimbrial assembly protein PilC;0.6613311659156835;0.1008169360353256;0.015868527492703288;0.4136850572121997;-0.2476461087034838
HELO_2971;130.54840180500324;68.56109440844337;188.4185474146633;180.82100628160188;171.58637419986735;183.78778892602102;2.057361692391645;1.0328970373133024;11.798244058811068;5.091576061365846;4.702992072834379;8.156695309546084;HELO_2971;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS10920;K;;pilC;;HELO_2971;TetR family transcription regulator;0.9192411852261246;0.03570817870013876;-0.09855085694331134;-0.4902757031370397;-1.4095168883631644
HELO_2972;159.02015924310558;217.97098177233397;239.52898271821695;234.7409981077714;275.41960452276277;226.66870187201994;7.6363479303079185;9.78801128434467;8.668969058448308;10.563084338373987;29.639744857440494;10.604177635127993;lexA;LexA repressor;COG1974;SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase);LexA;HELO_RS10925;KT;lexA; LexA repressor;3.4.21.88;lexA;LexA repressor;-0.45248602886131195;0.07927476850183623;0.2799239651172494;-0.5086823081642917;-0.05619627930297977
HELO_2973;54.070332039107484;79.43089617869254;37.29534547277681;44.98817055643201;37.73294459980155;39.75930719877298;3.529563541045667;2.3369804594854773;0.7448014476880507;1.6742716297811362;2.22329111819977;2.7397716525367497;dinB;DNA polymerase 4;COG0389;Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair;DinP;HELO_RS10930;L;dinB; DNA polymerase 4;2.7.7.7;dinB;DNA polymerase 4;-0.5464744879065293;-0.08996047621246994;-0.07356834595100015;0.43414577736575755;0.9806202652722869
HELO_2974;210.1149106563811;262.3594302128468;246.70478434287213;270.68561726672004;219.27901017520387;244.24341097668176;4.993043761832226;2.54900785402525;13.619247525092351;2.397962595466156;19.220910034097002;2.412236587554929;purU1;formyltetrahydrofolate deformylase;COG0788;Formyltetrahydrofolate hydrolase;PurU;HELO_RS10935;F;purU1; formyltetrahydrofolate deformylase;3.5.1.10;purU1;formyltetrahydrofolate deformylase;-0.31900464238457804;0.014407358397042103;-0.15488234481515928;-0.2161858985032099;0.10281874388136814
HELO_2975;81.6297265515483;65.51603319849006;107.27219675055028;154.23373797217673;112.63966371012647;106.92712024477794;2.137268544630861;1.5268787655021718;12.55758080668615;3.5806449305320687;6.086885730667519;1.1406033609178732;HELO_2975;RNase J domain protein;COG0595;mRNA degradation ribonuclease J1/J2;RnjA;HELO_RS10940;J;;purU1;3.1.-.-;HELO_2975;RNase J domain protein;0.3129587599122763;0.0046053853756946594;0.07440903228713314;-0.3853246365022116;-0.6982833964144879
HELO_2976;4705.17658622036;1445.1960964921745;4531.890879359872;4461.542315706852;2831.139732998757;2728.5322559457218;442.1388696247488;167.88365004631285;826.8926711487825;1926.1309494595496;734.711296149451;463.28784388517147;HELO_2976;H-NS domain protein;;;;;;;;;HELO_2976;H-NS domain protein;1.7022922673863317;0.7317776854560218;0.05323870124326646;0.7859017086326254;-0.9163905587537062
HELO_2977;295.44622520303477;292.0975301892076;268.93882935290463;350.72364307974914;324.09099777999353;276.7634737651442;15.93009376110704;7.369378249634539;12.089529584813002;12.350844008875002;34.663782240263984;9.984545042811181;moaA;GTP 3'%2C8-cyclase;COG2896;GTP 3',8-cyclase (molybdenum cofactor biosynthesis protein MoaA);MoaA;HELO_RS10950;H;moaA; GTP 3',8-cyclase;4.1.99.22;moaA;GTP 3'%2C8-cyclase;0.01638961520390758;-0.04122437942773338;0.22698671071902687;0.09391353065401375;0.07752391545010617
HELO_2978;171.43231601001017;114.82885266885872;80.16569396597292;102.8518541571322;92.69271161903147;85.3779472183706;1.3832044507085524;13.797612524841494;1.6982838721347742;4.0391268060344805;8.90837486110454;4.685937315976444;moaE;molybdopterin synthase catalytic subunit;COG0314;Molybdopterin synthase catalytic subunit MoaE;MoaE;HELO_RS10955;H;moaE; molybdopterin synthase catalytic subunit;2.8.1.12;moaE;molybdopterin synthase catalytic subunit;0.5740355094610541;-0.08979295401822007;0.11727379347576772;0.9972952429185549;0.4232597334575008
HELO_2979;188.10988528963185;147.54525517754755;172.58509568891907;194.7832315606478;185.66248552632234;166.46293046684477;5.611368921085516;3.4533785662830336;7.1639151563036565;11.066605987826746;3.8143834606962397;3.343437013608878;moaC;cyclic pyranopterin monophosphate synthase accessory protein;COG1977;Molybdopterin synthase sulfur carrier subunit MoaD;MoaD;HELO_RS10960;H;moaC; cyclic pyranopterin monophosphate synthase accessory protein;4.6.1.17;moaC;cyclic pyranopterin monophosphate synthase accessory protein;0.3483222554222367;0.05180130439027941;0.15659023474611633;0.17538300240081828;-0.17293925302141844
HELO_2980;235.91649175651312;121.44111569957421;138.70989524367624;170.57007497536037;161.32017626361824;146.143155742492;8.90802115199643;3.7868357638750063;6.39213568726832;5.542856420007309;5.942032051039251;24.171149773977792;mobB;molybdopterin-guanine dinucleotide biosynthesis protein MobB;COG1763;Molybdopterin-guanine dinucleotide biosynthesis protein;MobB;HELO_RS10965;H;mobB; molybdopterin-guanine dinucleotide biosynthesis protein MobB;;mobB;molybdopterin-guanine dinucleotide biosynthesis protein MobB;0.9522905320078374;-0.07478623168150822;0.14162189890967714;0.6871581901503561;-0.26513234185748136
HELO_2981;232.88945920490016;110.50950638868376;248.3259466819511;274.05068161692753;275.79389360637447;259.8130382927682;20.72659270619943;8.356794114673768;25.31996463672707;20.200111632275203;10.812395878826608;20.678342935504677;mobA;molybdenum cofactor guanylyltransferase;COG0746;Molybdopterin-guanine dinucleotide biosynthesis protein A;MobA;HELO_RS10970;H;mobA; molybdenum cofactor guanylyltransferase;2.7.7.77;mobA;molybdenum cofactor guanylyltransferase;1.0686601368377335;-0.06498296503200596;0.08579612272935755;-0.15718914846580923;-1.2258492853035428
HELO_2982;108.9557780933569;64.65491733704224;79.98366325886572;91.22615554824706;88.50838151518536;72.45934098046577;2.551363406848822;9.222087885236203;2.7488176587834774;11.090693292525659;7.324902901465054;4.177267537193703;puuR2;PuuR family transcription regulator PuuR;COG1396;Transcriptional regulator, contains XRE-family HTH domain;HipB;HELO_RS10975;K;puuR2; PuuR family transcription regulator PuuR;;puuR2;PuuR family transcription regulator PuuR;0.7439484453393801;0.14068495073853615;0.28507682846514637;0.5819055602101209;-0.16204288512925924
HELO_2983;37.46907753085922;45.70825912833734;41.87897031051829;45.30488158251953;53.372540615985976;39.005564400455675;1.3382324376864225;0.1199417021664675;0.876481160239879;0.37906755639010087;2.299660166451044;2.0856482300538652;HELO_2983;NCS2 family transport protein;COG2233;Xanthine/uracil permease;UraA;HELO_RS10980;F;;puuR2;;HELO_2983;NCS2 family transport protein;-0.2799784402544745;0.10006958217292006;0.44267756183730356;-0.0565014444181724;0.2234769958363021
HELO_2984;9.695026829203941;15.730349995088906;31.510789938352634;35.99259649151401;48.61468656442736;31.85636140207158;0.679200617519702;0.30882886984163577;1.9328372473381892;3.247999773672655;2.973688761870542;4.240547989700733;HELO_2984;FAD-dependent oxidoreductase;COG0578;Glycerol-3-phosphate dehydrogenase;GlpA;HELO_RS10985;C;;;1.1.5.3;HELO_2984;FAD-dependent oxidoreductase;-0.6455275249353236;-0.01525411070939331;0.5945945181344943;-1.6192326197698255;-0.9737050948345018
HELO_2985;72.94863789046155;96.54726412241631;458.97320929614233;549.4598836847391;767.1627393597204;491.85404542950147;2.6568282407849027;0.1807111128686178;59.30649593596239;21.889966586786546;52.371925252364846;88.99527531396237;HELO_2985;ABC-type transport system periplasmic substrate-binding protein;COG1653;ABC-type glycerol-3-phosphate transport system, periplasmic component;UgpB;HELO_RS10990;G;;;;HELO_2985;ABC-type transport system periplasmic substrate-binding protein;-0.3995778369835765;-0.09961063266858616;0.640251518061298;-2.7365649891646404;-2.336987152181064
HELO_2986;30.94121431965858;42.903470130533684;46.058150640879575;46.257070436519285;49.000320783054896;43.91963837673822;1.039268502219423;0.860919142360649;2.667130603823123;2.254503499760048;8.590075001251169;10.31371619274522;HELO_2986;DUF2160 domain protein;COG5477;Predicted small integral membrane protein;;HELO_RS10995;S;;;;HELO_2986;DUF2160 domain protein;-0.4589158136877627;0.06709831112209308;0.1545910372578323;-0.49192715223829264;-0.033011338550529956
HELO_2987;22.979028088357108;39.729356670991784;64.50854558729971;68.44773836847692;70.05136893494193;69.86221694761201;1.9118336176595725;1.5441443971266453;7.641889474779397;2.9164825925356737;5.884988164918364;6.9061451666468425;HELO_2987;ABC-type transport system permease protein;COG0395;ABC-type glycerol-3-phosphate transport system, permease component;UgpE;HELO_RS11000;G;;;;HELO_2987;ABC-type transport system permease protein;-0.7642958418385097;-0.11333348290793754;0.0038458445538811503;-1.5632434163458324;-0.7989475745073227
HELO_2988;23.65269470088103;39.04240611650469;72.3873132238652;75.58732815191878;78.86819644996005;73.93040920782772;1.141558292842209;1.834622023495869;8.144147427730402;6.239305033637527;4.520210605157103;4.149799501986104;HELO_2988;ABC-type transport system permease protein;COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS11005;G;;;;HELO_2988;ABC-type transport system permease protein;-0.6997833159495048;-0.030020650486287437;0.09206980542033172;-1.603805979065986;-0.9040226631164812
HELO_2989;31.45027796699395;40.667549572622654;117.8489424224256;139.942881575451;109.83386102742516;118.40859294255786;3.0976042622764153;2.2092101498609242;14.986222198786573;11.914853776768183;0.5652979637791002;13.559695118682924;HELO_2989;ABC-type transport system ATP-binding protein;COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS11010;G;;;;HELO_2989;ABC-type transport system ATP-binding protein;-0.36069342275647376;-0.006777594788261787;-0.10750795153736625;-1.8796039188778364;-1.5189104961213626
HELO_2990;37.2601416469573;43.48444210039579;137.43360566691047;177.37675135124928;123.55303499222087;146.6146678470701;3.0555418887529844;1.56007402789423;12.347432986727837;14.741938224480894;5.765331454122421;13.666886946319883;HELO_2990;ABC-type transport system ATP-binding protein;COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS11015;G;;;;HELO_2990;ABC-type transport system ATP-binding protein;-0.2174586441704669;-0.0926418738567305;-0.2450759067889674;-1.9479219630816162;-1.7304633189111494
HELO_2991;178.92402936650342;155.3765834037124;185.83563439502595;239.49503231460213;170.97582377749032;184.36350502308846;5.490834650457149;3.855252868567747;15.539428128304486;19.76617465011628;16.36367154875192;10.033122696923295;upp;uracil phosphoribosyltransferase;COG0035;Uracil phosphoribosyltransferase;Upp;HELO_RS11020;F;upp; uracil phosphoribosyltransferase;2.4.2.9;upp;uracil phosphoribosyltransferase;0.20236338289783262;0.011412411231163766;-0.10815146309655699;-0.04296935388581691;-0.24533273678364953
HELO_2992;186.2420806855033;219.70229116893788;153.95529682402008;127.62580066039992;128.70043917862006;146.2221263228311;8.389425445631579;10.882971328447496;10.12305331453011;6.851848787679169;3.903676946771848;10.899495258776907;ung;uracil-DNA glycosylase;COG0692;Uracil-DNA glycosylase;Ung;HELO_RS11025;L;ung; uracil-DNA glycosylase;3.2.2.27;ung;uracil-DNA glycosylase;-0.23719690481888556;0.07385755793114068;-0.1828111486532924;0.3469101885152588;0.5841070933341443
HELO_2993;233.6492966629668;355.97075142655285;147.51031027438924;117.48618977260992;130.68199870097226;134.4674560134865;5.652291028491889;31.871155872923417;4.79620991877977;10.76054183230971;10.74263651318241;12.434815571647903;gpt;xanthine phosphoribosyltransferase;COG0503;Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein;Apt;HELO_RS11030;F;gpt; xanthine phosphoribosyltransferase;2.4.2.22;gpt;xanthine phosphoribosyltransferase;-0.6052997351284057;0.1326167853199003;-0.04088816915277427;0.7925598282806385;1.3978595634090443
HELO_2994;218.09013013514922;266.81875774036445;198.4892676930746;163.05617203160477;166.80327506708574;191.30725351183287;2.4769411460508413;10.313230071933122;12.790685754980736;12.089570703270262;22.728683097973406;21.944462102993498;apt;adenine phosphoribosyltransferase;COG0503;Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein;Apt;HELO_RS11035;F;apt; adenine phosphoribosyltransferase;2.4.2.7;apt;adenine phosphoribosyltransferase;-0.2897325156854187;0.05289795332481706;-0.19664230621072498;0.18811131356151645;0.47784382924693514
HELO_2995;157.63004764952248;183.82647519583603;176.16275402132442;194.6654140529896;164.2368086839692;177.39549253865982;4.406566132870115;2.8299722141282695;6.833602759132879;6.157894767338621;8.546192322576623;6.749506303528054;HELO_2995;NCS2 family transport protein;COG2252;Xanthine/guanine/uracil/vitamin C permease GhxP/GhxQ, nucleobase:cation symporter 2 ( NCS2) family;NCS2;HELO_RS11040;F;;apt;;HELO_2995;NCS2 family transport protein;-0.22050535655022063;-0.010003834189823202;-0.1105440616539477;-0.16941309187913234;0.051092264671088294
HELO_2996;154.40512858168748;125.14706335956684;220.29736959277253;222.5187881093905;213.09248214369984;206.2260817566133;12.345843357047261;13.18848687443914;27.63912743493775;19.39994150831119;16.175476446517017;11.053549883392757;ribC;riboflavin synthase;COG0307;Riboflavin synthase alpha chain;RibC;HELO_RS11045;H;ribC; riboflavin synthase;2.5.1.9;ribC;riboflavin synthase;0.3009274939524227;0.09478070891958801;0.047028542371454485;-0.4151714785733924;-0.7160989725258151
HELO_2997;107.8208054155936;83.37753786543209;72.87293292099265;84.29272924896195;57.14843921584299;65.85148445945622;2.285115022603775;6.774199227672981;11.297457599155232;3.7909421929475964;6.383056315804567;10.201916197143765;metN;ABC-type transport system ATP-binding protein (probable substrate D-methionine);COG1135;ABC-type methionine transport system, ATPase component;AbcC;HELO_RS11050;E;metN; ABC-type transport system ATP-binding protein (probable substrate D-methionine);;metN;ABC-type transport system ATP-binding protein (probable substrate D-methionine);0.36702351589415283;0.14408626081690024;-0.20121912790048846;0.7029229100605612;0.33589939416640835
HELO_2998;81.23192964352593;70.9485048397799;50.85572297586483;78.62710782997705;44.248070528496534;52.23697885912414;9.045990723527366;5.409493042875502;6.893526338183259;5.688017193466481;6.705768081837024;3.616062596033096;metI;ABC-type transport system permease protein (probable substrate D-methionine);COG2011;ABC-type methionine transport system, permease component;MetP;HELO_RS11055;E;metI; ABC-type transport system permease protein (probable substrate D-methionine);;metI;ABC-type transport system permease protein (probable substrate D-methionine);0.19273397670733772;-0.03792548358230441;-0.23457242819119717;0.6272699811798912;0.43453600447255347
HELO_2999;736.7415368097289;558.6297995034544;555.8541194896599;507.29820197758914;601.4944710409146;596.6886818708425;53.40865599880139;8.700674803908708;52.58215297506999;11.960204627630528;16.264331502545463;74.58317455164405;metQ;ABC-type transport system periplasmic substrate-binding protein (probable substrate D-methionine);COG1464;ABC-type metal ion transport system, periplasmic component/surface antigen;NlpA;HELO_RS11060;P;metQ; ABC-type transport system periplasmic substrate-binding protein (probable substrate D-methionine);;metQ;ABC-type transport system periplasmic substrate-binding protein (probable substrate D-methionine);0.3986426794684519;-0.10209479291320633;0.011553778674915804;0.30372124207421614;-0.09492143739423575
HELO_3000;125.99325092519182;181.7920203634334;74.17345040450793;63.55256344904742;64.42884494576549;86.34368191784533;11.764062463437444;11.375791696312017;2.472873822560108;9.21563424759915;5.0638576109842415;8.660719380292232;msrC;methionine-R-sulfoxide reductase;COG1956;GAF domain-containing protein, putative methionine-R-sulfoxide reductase;MsrC;HELO_RS11065;VT;msrC; methionine-R-sulfoxide reductase;1.8.4.14;msrC;methionine-R-sulfoxide reductase;-0.5254512652984653;-0.2164801243336898;-0.41677654612716264;0.5399765733842008;1.065427838682666
HELO_3001;67.851949450715;72.86058222941386;106.55463951153945;102.87139432943646;93.49666854741595;103.18084321867552;3.2785962737838363;2.2121907524991244;17.11380591321543;1.2285668066263289;3.6250761254369324;10.103551797189688;glpK1;glycerol kinase;COG0554;Glycerol kinase;GlpK;HELO_RS11080;C;glpK1; glycerol kinase;2.7.1.30;glpK1;glycerol kinase;-0.10130713217259135;0.045979739530376484;-0.14075464558185846;-0.5975206111017775;-0.4962134789291861
HELO_3002;78.22865506047624;71.42157738830092;85.27370631664304;85.03357702298247;97.5196801505523;87.85870951315758;3.920550471594418;2.165120706121067;6.671034889119135;3.9778877790987983;3.3069889739174316;2.7011470610326165;glpR;DeoR family transcription regulator GlpR;COG1349;DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family;GlpR;HELO_RS11085;KG;glpR; DeoR family transcription regulator GlpR;;glpR;DeoR family transcription regulator GlpR;0.12960271210537933;-0.04259225391488464;0.1488987546842795;-0.16549087729013934;-0.29509358939551866
HELO_3003;10.62439805742205;9.435017902779633;14.572830527372238;18.50384095280089;10.181119038721905;14.296456835455198;0.4642959056792307;0.9569656857005173;1.9277855252577458;0.6969969158724302;1.4799989794413564;0.7900516200776545;glpD;glycerol-3-phosphate dehydrogenase;COG0578;Glycerol-3-phosphate dehydrogenase;GlpA;HELO_RS11090;C;glpD; glycerol-3-phosphate dehydrogenase;1.1.5.3;glpD;glycerol-3-phosphate dehydrogenase;0.15572293587617247;0.025833677598992022;-0.45213293130274756;-0.3960415042731409;-0.5517644401493134
HELO_3004;90.33158316543278;25.08087364790313;86.13215283914751;90.18844856826065;64.50401458116767;72.9068840892496;7.99557926619029;0.9035597104782371;15.983357082074232;16.007410333259706;8.49452751647169;3.6530044339795977;HELO_3004;homolog to phosphoglycerate mutase;COG0406;Broad specificity phosphatase PhoE;PhoE;HELO_RS11095;G;;glpD;;HELO_3004;homolog to phosphoglycerate mutase;1.80812164428768;0.23749643824470734;-0.1741254224775428;0.3054050904606651;-1.5027165538270149
HELO_3005;55.47890399316946;17.594763482462543;245.8395080665142;310.73743544978225;121.79450837707084;269.7290830047545;1.824355184024712;1.3221898111561166;35.85140847445183;31.851041966025726;5.743069907796343;69.80176508017763;HELO_3005;ABC-type transport system periplasmic substrate-binding protein;COG3221;ABC-type phosphate/phosphonate transport system, periplasmic component;PhnD;HELO_RS11100;P;;;;HELO_3005;ABC-type transport system periplasmic substrate-binding protein;1.6028156949276209;-0.13327655252420723;-1.1406038351738736;-2.2610658794003697;-3.8638815743279906
HELO_3006;10.673288867496366;2.6503839926940422;39.01318144447459;54.355248887795575;23.22784611687223;42.41503434896698;1.1936866818229863;0.5354887223245252;2.3802961071422413;3.4442238663598475;2.5828304827911985;6.720538510025121;HELO_3006;ABC-type transport system ATP-binding protein;COG3638;ABC-type phosphate/phosphonate transport system, ATPase component;PhnC;HELO_RS11105;P;;;7.3.2.2;HELO_3006;ABC-type transport system ATP-binding protein;1.6770909498957498;-0.11771938346929556;-0.8415285720099117;-1.894983637713206;-3.572074587608956
HELO_3007;5.3213740478277805;1.9111332650514126;18.695719352953777;24.144080403415746;13.460360697669174;21.74728567528184;0.1816106300439644;0.4101380244685863;2.5553424226648653;1.8794630391958058;1.7130704831289503;1.88557307610492;HELO_3007;ABC-type transport system permease protein;COG3639;ABC-type phosphate/phosphonate transport system, permease component;PhnE;HELO_RS11110;P;;;;HELO_3007;ABC-type transport system permease protein;1.1186573001690876;-0.20781229576871763;-0.6535908665212458;-1.8473843161401007;-2.9660416163091883
HELO_3008;7.62528570002947;1.6121012415193041;19.871918419211255;24.657571796486653;15.307955324709416;19.42505522108718;0.5068847598233434;0.2457797002128794;0.6195705480798512;1.6528214597268458;0.3201342525502946;0.9851380224047775;HELO_3008;ABC-type transport system permease protein;COG3639;ABC-type phosphate/phosphonate transport system, permease component;PhnE;HELO_RS11115;P;;;;HELO_3008;ABC-type transport system permease protein;1.7233614298611473;0.03122323146526984;-0.324764069127359;-1.2436958289852629;-2.96705725884641
HELO_3009;47.527205291563575;6.087632065435518;14.37792289234025;26.928143184133138;12.75954296737468;13.055305711744689;1.356332086542901;0.34888207360743295;0.8596049466493324;1.5169352441332946;1.010540990652115;1.8040254014645978;HELO_3009;nuclease/phosphatase domain protein;COG3021;Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily;YafD;HELO_RS11120;R;;;;HELO_3009;nuclease/phosphatase domain protein;2.775418159416053;0.12974581696548437;-0.030682282850725606;1.7876789433091944;-0.9877392161068586
HELO_3010;227.13698400743712;245.99395077860672;253.60737751958365;326.81856125209856;366.83429986112;248.08464941862022;6.128501663157923;8.436891062014523;11.757672871709097;15.116986535809945;3.5403185943486104;16.07239911024573;ppc;phosphoenolpyruvate carboxylase;COG2352;Phosphoenolpyruvate carboxylase;Ppc;HELO_RS11125;C;ppc; phosphoenolpyruvate carboxylase;4.1.1.31;ppc;phosphoenolpyruvate carboxylase;-0.11457536319593675;0.03163810951713675;0.5624199006880586;-0.1267357684892776;-0.012160405293340837
HELO_3011;167.8433339172104;121.43705945189102;123.16565906984329;152.41761095297423;132.46706922992547;127.9619453926481;5.379082436589323;8.602417068309984;1.9253749628614163;1.712188209778283;1.523091132787326;2.538517101297283;mazG;nucleoside triphosphate pyrophosphohydrolase MazG;COG3956;Uncharacterized conserved protein YabN, contains tetrapyrrole methylase and MazG-like pyrophosphatase domain;YabN;HELO_RS11130;R;mazG; nucleoside triphosphate pyrophosphohydrolase MazG;3.6.1.9;mazG;nucleoside triphosphate pyrophosphohydrolase MazG;0.46364492015036785;-0.054679194698366906;0.04953841269844972;0.388739809388829;-0.07490511076153883
HELO_3012;190.17291331443593;111.29708682853523;105.18202626112934;120.44600902194078;109.2605774881913;104.92571749938924;4.228229429002328;3.063504393172369;1.59064311493171;4.077345743528817;2.746781137913678;6.482289506789599;relA;GTP pyrophosphokinase;COG0317;(p)ppGpp synthase/hydrolase, HD superfamily;SpoT;HELO_RS11135;KT;relA; GTP pyrophosphokinase;2.7.6.5;relA;GTP pyrophosphokinase;0.7675576245627269;0.0034866766571148844;0.05786416166905273;0.851825225913224;0.08426760135049705
HELO_3013;324.62975285354815;194.976760677503;247.8368858157227;285.10333090268074;283.3779469210984;247.06467279223762;4.3081225404079895;7.088329717509861;10.150198568272277;7.690443762931264;11.8817869505823;12.558934047254384;rlmD;23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;COG2265;tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family;TrmA;HELO_RS11140;J;rlmD; 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;2.1.1.190;rlmD;23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;0.7325499381782308;0.004484062394460864;0.19709329667056075;0.39251623114177114;-0.34003370703645963
HELO_3014;315.7312674773676;203.14852879421562;268.6205557395313;306.11237800230333;313.53948037961555;251.5481467865038;10.226201789696894;4.155757806059032;7.288497563713346;10.234568856334676;14.675035052491804;6.075522641701281;cysM;cysteine synthase;COG0031;Cysteine synthase;CysK;HELO_RS11145;E;cysM; cysteine synthase;2.5.1.144;cysM;cysteine synthase;0.6336401254357531;0.09437203585338771;0.31668265750154845;0.3267008409630119;-0.3069392844727412
HELO_3015;47.867537094638145;17.325805210344043;28.64681570115165;35.83140665989722;35.24166235712312;29.695988418129602;2.006370230348182;1.3962475161185912;2.0910865931886167;3.353281387247211;2.7898459325640226;2.1226061237276967;HELO_3015;sensor histidine kinase / response regulator;COG2198;HPt (histidine-containing phosphotransfer) domain;HPtr;HELO_RS11150;T;;cysM;2.7.13.3;HELO_3015;sensor histidine kinase / response regulator;1.4149998053716981;-0.05017296930006765;0.23959900570370873;0.6708262694214389;-0.7441735359502593
HELO_3016;87.12408081398803;85.88721612438377;74.0553895833714;86.12800423732766;81.27586926278833;70.37435266632991;8.57099127623358;3.6339002666305147;7.013466354864954;4.967867759191554;8.673478408975727;3.215880956769066;acpS;holo-[acyl-carrier-protein] synthase;COG0736;Phosphopantetheinyl transferase (holo-ACP synthase);AcpS;HELO_RS11155;I;acpS; holo-[acyl-carrier-protein] synthase;2.7.8.7;acpS;holo-[acyl-carrier-protein] synthase;0.020392378035322345;0.07254991679395939;0.20506360789118094;0.3041305483874428;0.28373817035212046
HELO_3017;99.00097924785995;85.8467356568351;113.62534320744311;107.9031181671808;121.75951651322066;116.01765475703353;3.6906315178550297;0.2994028685093767;14.808837989502143;5.711378572973943;8.495522456540836;5.841207779429849;pdxJ;pyridoxine 5'-phosphate synthase;COG0854;Pyridoxine 5'-phosphate synthase PdxJ;PdxJ;HELO_RS11160;H;pdxJ; pyridoxine 5'-phosphate synthase;2.6.99.2;pdxJ;pyridoxine 5'-phosphate synthase;0.20347059958218772;-0.029800155875203238;0.06910865952015932;-0.22671208188103176;-0.4301826814632195
HELO_3018;182.85914466986284;193.0796384906987;131.82261577441966;144.30930562895912;117.53548381158218;133.3822238506841;2.1048931304645477;10.296177755081784;10.415254405081729;7.050358498079895;11.171141759765321;14.346805888377345;recO;DNA repair protein RecO;COG1381;Recombinational DNA repair protein RecO (RecF pathway);RecO;HELO_RS11165;L;recO; DNA repair protein RecO;;recO;DNA repair protein RecO;-0.07804783410732341;-0.01684149427998971;-0.18102331315107545;0.4522586238795503;0.5303064579868737
HELO_3019;203.5266627810835;267.66132488307966;275.6637567775496;335.82612646241927;261.0834287629025;288.55090265369944;12.431068375883974;18.111684980599453;15.575716287242638;21.67695946310702;17.604036692305286;11.73860055633268;era;ribosome biogenesis protein Era;COG1159;GTPase Era, involved in 16S rRNA processing;Era;HELO_RS11170;J;era; ribosome biogenesis protein Era;;era;ribosome biogenesis protein Era;-0.3934997232761779;-0.06568333246455715;-0.14379085774702638;-0.501528064343856;-0.10802834106767811
HELO_3020;325.2572611642808;251.73549298694402;247.63102655796297;309.8743668702532;200.77484720849884;223.3550036651403;21.082899931940357;20.70456419013025;11.69517922889987;11.122292432625223;9.606753266043635;8.958989812814655;rnc;ribonuclease 3;COG0571;dsRNA-specific ribonuclease;Rnc;HELO_RS11175;K;rnc; ribonuclease 3;3.1.26.3;rnc;ribonuclease 3;0.3683817267503269;0.14822298091293806;-0.15303701741515852;0.5402266505841258;0.1718449238337989
HELO_3021;283.33310071253464;275.35352702707877;219.14451480807506;234.20588416067366;224.76063632735065;217.56517076450226;8.396379387866768;13.489568943289084;12.04689172072954;4.200976856363323;14.615997137781253;1.3020406514299567;lepB;signal peptidase I;COG0681;Signal peptidase I;LepB;HELO_RS11180;U;lepB; signal peptidase I;3.4.21.89;lepB;signal peptidase I;0.04106703510869458;0.010387377974839573;0.04673043933211041;0.37951854042246325;0.33845150531376866
HELO_3022;277.1264918799328;295.46861585020406;294.1799914687722;320.0571685005488;329.9453159976028;280.3753112214568;10.07281646798592;10.198694926279524;15.57692098853842;5.801799928215922;25.30454280452682;12.431858570757605;lepA;translation elongation factor LepA;COG0481;Translation elongation factor EF-4, membrane-bound GTPase;LepA;HELO_RS11185;J;lepA; translation elongation factor LepA;;lepA;translation elongation factor LepA;-0.0921382195920657;0.0690991854187164;0.23409710450127896;-0.016754577753165023;0.07538364183890067
HELO_3023;58.398828548243095;10.3372712840969;18.791692977171863;24.166191775033237;16.96742678352611;14.373879631402493;0.8884602919004928;0.8008659101945144;1.652178428032929;4.010761085998308;1.337318899570194;1.634562135043713;HELO_3023;DUF1501 domain protein;COG4102;Uncharacterized conserved protein, DUF1501 family;;HELO_RS11190;S;;lepA;;HELO_3023;DUF1501 domain protein;2.389361032366443;0.3644137473364033;0.2249025290005786;1.9499532006132085;-0.4394078317532344
HELO_3024;79.15402087358139;7.7174527225971055;23.47102960635658;30.951772525761186;21.429409925709546;18.532040747417877;2.3523500645137942;0.17597521300943564;1.7662852303315406;5.266963228219155;3.5699091422520284;1.552910159339154;HELO_3024;DUF1800 domain protein;COG5267;Uncharacterized conserved protein, DUF1800 family;;HELO_RS11195;S;;;;HELO_3024;DUF1800 domain protein;3.200796354079198;0.3252321105505702;0.19954897359640622;2.036932201222638;-1.16386415285656
HELO_3025;705.8251831132775;14.442601027501004;285.38261903819665;271.282001586661;129.6991920068211;167.38508367498443;70.21438206671947;2.570044112142186;48.203566492472454;58.41968087731826;58.691927302575564;70.58012185480423;HELO_3025;DUF2501 domain protein;;;;;;;;;HELO_3025;DUF2501 domain protein;5.516365767716536;0.766179592574991;-0.3655141212024846;2.0695890983459186;-3.446776669370618
HELO_3026;1246.9070075082584;100.3591092305539;433.37800791928197;416.4913115842448;499.43446192554416;364.10654616132297;17.82661862015689;2.677366132907517;12.812815574728107;15.484605201572773;108.12039747246496;43.686592736864;degP1;serine endoprotease DegP;COG0265;Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain;DegQ;HELO_RS11205;O;degP1; serine endoprotease DegP;3.4.21.107;degP1;serine endoprotease DegP;3.621962774358395;0.25063352718806087;0.4548636069552412;1.7731209894969133;-1.8488417848614818
HELO_3027;746.2125061121816;116.04355664781231;191.0915377491066;225.5722843638994;183.1563295335478;169.99199156449598;5.531737816353729;3.0585828118585745;8.18347352115746;9.357277404756761;15.258281904336188;11.460343488280719;rseB;sigma-E factor regulator protein RseB;COG3026;RseB, negative regulator of sigma E activity;RseB;HELO_RS11210;T;rseB; sigma-E factor regulator protein RseB;;rseB;sigma-E factor regulator protein RseB;2.6744730866811564;0.16786520718500597;0.1070022262936643;2.1275898438129746;-0.5468832428681818
HELO_3028;1097.3270651885925;181.88261078836982;468.84769023787504;500.70339873181416;411.1010464234468;408.594311645564;39.09686993132837;12.837994497583496;38.06207251353595;35.37246223547143;56.92711187431863;20.542806226401133;rseA;anti-sigma-E factor RseA;COG3073;RseA, negative regulator of sigma E activity;RseA;HELO_RS11215;T;rseA; anti-sigma-E factor RseA;;rseA;anti-sigma-E factor RseA;2.586317921591638;0.19799747682001367;0.008802447321849982;1.4230401463225828;-1.163277775269055
HELO_3029;451.6106099831689;162.53904398895043;301.98469500424613;320.67678098456093;239.55220003770907;284.7799279474212;16.210614681161868;7.580402087131035;26.7431391247893;17.187355199273668;17.3276710870255;18.692318424958213;rpoE;RNA polymerase sigma factor RpoE;COG1595;DNA-directed RNA polymerase specialized sigma subunit, sigma24 family;RpoE;HELO_RS11220;K;rpoE; RNA polymerase sigma factor RpoE;;rpoE;RNA polymerase sigma factor RpoE;1.4686352924552084;0.08434032831886462;-0.24855459674152325;0.6633658134978848;-0.8052694789573236
HELO_3030;365.87040384383425;209.47580619883527;549.4679245130582;454.5302917975269;483.0465784899914;553.5723019899808;29.56398243132612;7.248744440713583;33.233070544456545;15.746010819598625;30.758230699112335;55.059164379967314;aroF1;phospho-2-dehydro-3-heoxyheptonate aldolase;COG0722;3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase;AroG1;HELO_RS11225;E;aroF1; phospho-2-dehydro-3-heoxyheptonate aldolase;2.5.1.54;aroF1;phospho-2-dehydro-3-heoxyheptonate aldolase;0.8016161165183533;-0.010717061912425052;-0.19622968223005266;-0.5961050388047262;-1.3977211553230795
HELO_3031;92.47636234040971;90.16136831210927;58.745105995813255;75.98721267602455;60.86502059210429;54.81913210615525;3.9293888081968973;4.230246579570634;1.3612236162490183;5.003949629075321;5.070151836120113;4.101230834439078;HELO_3031;uncharacterized protein;;;;;;;;;HELO_3031;uncharacterized protein;0.036179013018348805;0.09806084686840055;0.14836422551892614;0.7438418992284728;0.707662886210124
HELO_3032;179.77431217822308;239.78264463096272;218.68065070579112;247.01330061666818;235.58104995274005;225.1126225184588;8.88958361364123;10.664293945043028;17.288928515948953;8.109200082568544;15.659636167484782;8.26899501779609;dinG;ATP-dependent DNA helicase DinG;COG1199;Rad3-related DNA helicase DinG;DinG;HELO_RS11235;L;dinG; ATP-dependent DNA helicase DinG;3.6.4.12;dinG;ATP-dependent DNA helicase DinG;-0.41354172083669827;-0.04163372744922622;0.06529298761837854;-0.3228518443810158;0.0906898764556825
HELO_3033;315.40860878561324;362.36294294775115;465.373038310998;521.3041990283535;529.2341036042236;474.1260948213083;6.648380435207101;8.129338571656278;44.142948592796905;42.03669594342874;61.82275160781332;33.49170643704163;rhlB;ATP-dependent RNA helicase RhlB;COG0513;Superfamily II DNA and RNA helicase;SrmB;HELO_RS11240;L;rhlB; ATP-dependent RNA helicase RhlB;3.6.4.13;rhlB;ATP-dependent RNA helicase RhlB;-0.19962244295624387;-0.02682605776168856;0.15831902001089304;-0.5865215915389257;-0.3868991485826818
HELO_3034;32.380500995203576;18.684903586060788;42.70142296044384;37.89638216901566;47.56244617721027;38.28622078924266;1.3745704406137227;5.910401483157254;11.404517951781049;2.8105800138626593;10.181841294281414;6.404668431619685;HELO_3034;uncharacterized protein;;;;;;;;;HELO_3034;uncharacterized protein;0.7619159613292421;0.15365686428101544;0.30581770280127873;-0.2350177840279919;-0.996933745357234
HELO_3035;132.5188267095157;66.65890097019678;137.27368063967472;139.07868048467645;174.16496212510256;148.3658431729351;1.919532836098257;1.4984201967984814;14.149161612819334;12.264741943324127;9.17357043117595;10.3533744487665;xthA1;apurinic/apyrimidinic DNA endonuclease XthA;COG0708;Exonuclease III;XthA;HELO_RS11250;L;xthA1; apurinic/apyrimidinic DNA endonuclease XthA;3.1.11.2;xthA1;apurinic/apyrimidinic DNA endonuclease XthA;0.9806915345006288;-0.11132369541341447;0.22986395274730853;-0.1618070895754089;-1.1424986240760377
HELO_3036;125.24555690758893;71.76178727754528;107.15684175546362;119.43073070223782;124.80778814954503;109.93362487383531;3.50760333449874;3.225025248616185;34.573882032826766;6.723919426518236;4.754393019887676;56.8687817376779;HELO_3036;TPR domain protein;;;;;;;;;HELO_3036;TPR domain protein;0.7949797284311142;-0.03657179446678427;0.1815245109738317;0.18653589022123995;-0.6084438382098742
HELO_3037;129.64990994398877;75.12941930975298;65.88142536624154;60.29574076571083;72.72733948420255;65.71476132950744;7.064435882324801;2.8953005961946627;18.249886573898586;1.5941795340871519;1.337628975527447;29.840664188281448;HELO_3037;TonB-like protein;COG0810;Periplasmic protein TonB, links inner and outer membranes;TonB;HELO_RS11260;M;;;;HELO_3037;TonB-like protein;0.7791801512672647;0.0035995863351141466;0.1441936890941049;0.9696282172093671;0.1904480659421024
HELO_3038;89.2558150448135;66.82775277789897;20.917751390164998;19.09660107542102;18.193139183145387;19.979233444649367;1.782754163478023;6.4486839622353935;7.730509044614111;2.8667240810146226;1.4662993120502472;8.377098627926438;HELO_3038;ExbD family protein;COG0848;Biopolymer transport protein ExbD;ExbD;HELO_RS11265;U;;;;HELO_3038;ExbD family protein;0.41214419041021433;0.06313783077022883;-0.12837127005549664;2.1050579210619453;1.692913730651731
HELO_3039;131.190770524899;82.76308417062815;51.702551638140335;52.66526629779836;56.746311988099194;65.55632227471476;3.6106049448859014;8.234179233858324;12.21967047852116;8.219630667587083;3.6498668653661577;32.4962844641342;HELO_3039;ExbB family protein;COG0811;Biopolymer transport protein ExbB/TolQ;TolQ;HELO_RS11270;U;;;;HELO_3039;ExbB family protein;0.6582349836866381;-0.3367029033508899;-0.20484690553139995;0.9899738310115831;0.33173884732494496
HELO_3040;241.60070325261145;157.23089304813183;178.5630066728643;164.11230783819937;183.07696103619375;203.97479578651027;8.113736367569041;12.397507551640059;56.07343015753978;21.180856039802727;6.727760620258746;123.28566151336712;HELO_3040;DUFx/ExbB domain protein;COG0811;Biopolymer transport protein ExbB/TolQ;TolQ;HELO_RS11275;U;;;;HELO_3040;DUFx/ExbB domain protein;0.6165524330251104;-0.19095636463076548;-0.15513745211951147;0.24313720931260718;-0.37341522371250324
HELO_3041;288.3395386590508;154.64842396104874;255.50684053735264;229.31682259826889;230.2582048454683;287.0697457299752;20.94103714534845;5.780385290098127;93.24529984871043;9.717807542846755;31.122883718280526;168.97715523339684;HELO_3041;DUF3450 family protein;;;;;;;;;HELO_3041;DUF3450 family protein;0.8944725143867176;-0.16742085047482647;-0.3169135985477025;0.006345332381773261;-0.8881271820049443
HELO_3042;599.8202808287824;728.1353648576065;887.005275869788;680.9083771814841;966.4579641965242;905.6455599599531;5.74662280642724;33.06092246019869;55.425751335132915;2.9138308147201664;50.03527062026143;24.962740914894308;etfA;electron transfer flavoprotein alpha subunit;COG2025;Electron transfer flavoprotein, alpha subunit FixB;FixB;HELO_RS11285;C;etfA; electron transfer flavoprotein alpha subunit;;etfA;electron transfer flavoprotein alpha subunit;-0.2792531653054855;-0.029970412068788477;0.09366031778949058;-0.5936051479133813;-0.31435198260789576
HELO_3043;523.8870005444304;760.8068681420868;1039.8508858368727;867.1405657546917;1082.8531841279082;1028.3384982915693;28.734287025035048;40.75863688707008;66.71910809593683;25.813619814642053;60.19408522128666;104.61419513021433;etfB;electron transfer flavoprotein beta subunit;COG2086;Electron transfer flavoprotein, alpha and beta subunits;FixA;HELO_RS11290;C;etfB; electron transfer flavoprotein beta subunit;;etfB;electron transfer flavoprotein beta subunit;-0.5374184267943001;0.016045909384905244;0.07445185531093657;-0.9716387179467922;-0.43422029115249217
HELO_3044;144.16179103239102;209.6852429175907;257.9008429174191;239.0059747559752;257.31699413285173;250.6182086089444;7.368196906522402;8.044975356341736;16.772121789898236;3.7167017524540267;13.845877849865053;22.872799763151804;etfD;electron transfer flavoprotein--ubiquinone oxidoreductase;COG2440;Ferredoxin-like protein FixX;FixX;HELO_RS11295;C;etfD; electron transfer flavoprotein--ubiquinone oxidoreductase;1.5.5.1;etfD;electron transfer flavoprotein--ubiquinone oxidoreductase;-0.5374275043505916;0.04116333420887042;0.037906230359934234;-0.793574565825117;-0.2561470614745254
HELO_3045;257.1190569218722;119.19082614180196;79.34527394618648;76.37295461006336;66.33071947554858;64.53180351710263;10.299645695929595;2.709308658315669;8.720007126598599;19.200550198731086;6.732953307578815;6.059693485149633;HELO_3045;glutaredoxin domain protein;;;;;;;;;HELO_3045;glutaredoxin domain protein;1.102709876462968;0.29401792742944366;0.03906964406636959;1.977769517336668;0.8750596408737001
HELO_3046;145.4772192975178;112.10402981501471;107.77267365436218;123.45083340637613;114.66315325318982;107.54949924430416;4.776704572296834;5.417695758700628;3.8192966819787193;3.5063769796336683;3.389564831851675;4.541970198462948;rlmKL;ribosomal RNA large subunit methyltransferase RlmKL;COG1092;23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI;RlmK;HELO_RS11305;J;rlmKL; ribosomal RNA large subunit methyltransferase RlmKL;2.1.1.173,2.1.1.264;rlmKL;ribosomal RNA large subunit methyltransferase RlmKL;0.3730259761651693;0.002963091372885529;0.09157626848286426;0.43232323800035033;0.059297261835181025
HELO_3047;197.33232971874074;204.65361482247116;180.8737397460054;248.36613680163524;212.84837961539665;178.70181955935035;1.5451658205199859;3.9856945495838114;7.169607087537902;4.222232121536147;11.788407424377704;5.229655735203881;pyrD;dihydroorotate dehydrogenase (quinone);COG0167;Dihydroorotate dehydrogenase;PyrD;HELO_RS11315;F;pyrD; dihydroorotate dehydrogenase (quinone);1.3.5.2;pyrD;dihydroorotate dehydrogenase (quinone);-0.05229656335939392;0.01733223437950482;0.2509832587426448;0.14231485045669334;0.19461141381608726
HELO_3048;58.92630003102109;26.838420534583776;37.5459445209792;54.679015592264705;43.372700563093325;41.16104087172758;1.5627479684022771;0.47307171282443533;3.8742120445798833;2.321819938265449;2.7556460712571544;2.3570773918784282;HELO_3048;MgtE family transport protein;COG2239;Mg/Co/Ni transporter MgtE (contains CBS domain);MgtE;HELO_RS11320;P;;pyrD;;HELO_3048;MgtE family transport protein;1.1061119423180612;-0.1293314047419143;0.07376187490005659;0.5072788171279239;-0.5988331251901373
HELO_3049;217.61178588279358;90.61940786890882;160.71660175396076;153.19327483052453;206.05170241473533;183.99549875422142;4.229797861401661;3.6221402183657387;13.691338371010572;2.1121645655514687;12.188247840216606;23.24855624730247;gdh;glutamate dehydrogenase (NAD);COG2902;NAD-specific glutamate dehydrogenase;Gdh2;HELO_RS11325;E;gdh; glutamate dehydrogenase (NAD);1.4.1.2;gdh;glutamate dehydrogenase (NAD);1.2546460382955793;-0.1940223751758543;0.16250089682605573;0.24088101421973818;-1.0137650240758411
HELO_3050;58.04049059218497;37.76210994640525;49.513608629409724;39.6167569014851;59.909857288110345;51.49434092787519;3.227565371613915;0.7341388696042098;5.15481756178081;3.9393814193613648;4.307058352934604;3.345598441051883;trmA;tRNA/tmRNA (uracil-C(5))-methyltransferase;COG2265;tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family;TrmA;HELO_RS11330;J;trmA; tRNA/tmRNA (uracil-C(5))-methyltransferase;2.1.1.35;trmA;tRNA/tmRNA (uracil-C(5))-methyltransferase;0.6070576059809776;-0.055489793838254364;0.2145138205595174;0.16954280577663727;-0.4375148002043403
HELO_3051;132.71323905713243;67.20980177905766;71.5287760188963;76.0559217141186;85.47797770299381;74.53498324330616;7.892146975221449;0.6794250940002063;3.5280076596939347;2.2180648611082834;6.006438240570846;1.238425178430948;murI;glutamate racemase;COG0796;Glutamate racemase;MurI;HELO_RS11335;M;murI; glutamate racemase;5.1.1.3;murI;glutamate racemase;0.9710913397362795;-0.0585914659637119;0.19518781744119718;0.8239254413623538;-0.14716589837392569
HELO_3052;108.33492331399617;12.389266567102721;27.472951974148376;43.717884861466466;38.65894310674918;23.455405106179665;4.502262763656111;0.899689424990037;4.088853783599656;8.578643118372137;3.351192848943906;3.074367918127029;HELO_3052;haemerythrin domain protein;COG3945;Hemerythrin domain;;HELO_RS11340;R;;murI;;HELO_3052;haemerythrin domain protein;3.029605453912365;0.2194387110544227;0.6974928676376075;2.1605290260001615;-0.8690764279122036
HELO_3053;116.49053374794761;90.86816539468896;105.50506995351282;129.43300224615692;133.80146625750547;106.4189720082159;4.1251490499858186;6.490012291105729;4.833039230828322;8.763877870501881;9.735278562496804;8.969373212571487;rarA;DNA-dependent ATPase RarA;COG2256;Replication-associated recombination protein RarA (DNA-dependent ATPase);RarA;HELO_RS11345;L;rarA; DNA-dependent ATPase RarA;;rarA;DNA-dependent ATPase RarA;0.35490759955017115;-0.012326711586591266;0.32758736884899875;0.12929570286011494;-0.2256118966900562
HELO_3054;42.9686140034413;31.109120438490645;45.61442077089179;56.75022492527997;51.2212974290122;44.93658828603248;0.5006099569689685;1.8627553188829444;4.194463029068164;3.742976440652174;0.9133800400310267;1.7284065417561731;HELO_3054;YjiR family protein;COG1167;DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain;ARO8;HELO_RS11350;KE;;rarA;;HELO_3054;YjiR family protein;0.4534909100239908;0.021132628583615976;0.18499458998002272;-0.06316965557562959;-0.5166605655996204
HELO_3055;10.311027896684298;4.666578079913662;4.334193706219825;6.814387564730249;11.313074611934637;4.861882680259882;0.5514511517178144;0.5432690778371546;0.5413600404991152;0.6576801145702948;0.2471532788773158;1.5518636974138398;HELO_3055;major facilitator superfamily transport protein;;;;;;;;;HELO_3055;major facilitator superfamily transport protein;0.9971803492161762;-0.13609387826133057;1.0707550527923302;0.9482940417674919;-0.048886307448684274
HELO_3056;345.7884344385402;155.4817029391758;239.10832500547053;285.25893141757496;230.29997574829338;250.7417064117113;7.249561086561018;5.922106951504575;11.326187218006242;10.362124170277832;17.14183319280064;19.22212653568399;lolA;outer-membrane lipoprotein carrier protein LolA;COG2834;Outer membrane lipoprotein-sorting protein;LolA;HELO_RS11360;M;lolA; outer-membrane lipoprotein carrier protein LolA;;lolA;outer-membrane lipoprotein carrier protein LolA;1.1480618089206507;-0.06825882429338836;-0.1221791349607182;0.46211153511812686;-0.6859502738025238
HELO_3057;217.20146388163116;140.21687962006527;227.2127051998674;342.3340354166166;219.5843180601182;221.9024712133215;5.393783301919153;1.694907731112733;14.427198627908195;9.217037595567142;19.415995452924598;19.984127539716365;ftsK;DNA translocase FtsK;COG1674;DNA segregation ATPase FtsK/SpoIIIE or related protein;FtsK;HELO_RS11365;D;ftsK; DNA translocase FtsK;;ftsK;DNA translocase FtsK;0.6277482366120104;0.033966501321616605;-0.015082381702108627;-0.0307518306342347;-0.6585000672462451
HELO_3058;51.56010754428903;55.40179774674147;52.77024116462473;58.90137886398535;58.96138001803629;51.875829691756344;1.3309394101441412;3.8611302711924624;4.297348873571527;2.440914868066407;2.564837867182093;2.683820495442385;aat;leucyl/phenylalanyl-tRNA--protein transferase;COG2360;Leu/Phe-tRNA-protein transferase;Aat;HELO_RS11370;O;aat; leucyl/phenylalanyl-tRNA--protein transferase;2.3.2.6;aat;leucyl/phenylalanyl-tRNA--protein transferase;-0.10177292012177475;0.02419954604680541;0.18142519125466272;-0.008640168614507893;0.09313275150726685
HELO_3059;68.34831787453585;39.10793679612185;36.19478525153282;38.929009699901336;46.23693926759797;36.4466924325361;4.990938738754309;1.5404742074860525;0.7187059396499444;0.8809932498963446;1.917112031538079;6.151413232717632;ate;probable arginyl-tRNA--protein transferase;COG2935;Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase;Ate1;HELO_RS11375;O;ate; probable arginyl-tRNA--protein transferase;2.3.2.29;ate;probable arginyl-tRNA--protein transferase;0.7899731347269965;-0.009737926736663738;0.33507719301459726;0.88902259383093;0.09904945910393348
HELO_3060;2053.2016894812373;2719.7917127662854;3300.322834528047;3479.4869151185935;3466.2574215905165;3336.457594053311;269.425828973602;863.6311343456729;242.5734445333542;140.20345157246567;489.1792704628903;576.5031512577674;infA;translation initiation factor IF-1;COG0361;Translation initiation factor IF-1;InfA;HELO_RS11380;J;infA; translation initiation factor IF-1;;infA;translation initiation factor IF-1;-0.40544867887442493;-0.01570528013600203;0.0550454454137963;-0.7001716679429695;-0.29472298906854455
HELO_3061;386.35886327465124;216.88983268509;290.1730412506027;326.9068840899499;301.83392171110154;284.3016340136474;5.312117761630163;9.125036807532993;26.882892380641742;5.4529431798773125;31.426011212892572;29.546845573511007;clpA;ATP-dependent Clp protease ATP-binding subunit ClpA;COG0542;ATP-dependent Clp protease, ATP-binding subunit ClpA;ClpA;HELO_RS11385;O;clpA; ATP-dependent Clp protease ATP-binding subunit ClpA;;clpA;ATP-dependent Clp protease ATP-binding subunit ClpA;0.8300718727252354;0.029388777636008;0.08603880704253619;0.4411827410708522;-0.3888891316543832
HELO_3062;611.2603945697371;729.138169243624;575.2214910161056;622.6693498243111;560.6553858801058;621.133903993687;37.29778946116789;34.728647633912466;17.314280897662588;26.784427612417574;23.82331695207366;52.057431009097364;clpS;ATP-dependent Clp protease adapter protein ClpS;COG2127;ATP-dependent Clp protease adapter protein ClpS;ClpS;HELO_RS11390;O;clpS; ATP-dependent Clp protease adapter protein ClpS;;clpS;ATP-dependent Clp protease adapter protein ClpS;-0.25402413911990607;-0.1106016610273386;-0.14753992043886832;-0.02307976777110987;0.2309443713487962
HELO_3063;509.1613894359246;626.7964670156656;782.7031612951741;743.3688181252525;1039.610370343182;829.5902019237668;14.484238266675586;15.16940150961907;72.10743264617894;46.78496975177996;53.46208812553454;58.31011698083114;icd;isocitrate dehydrogenase (NADP);COG2838;Monomeric isocitrate dehydrogenase;IcdM;HELO_RS11395;C;icd; isocitrate dehydrogenase (NADP);1.1.1.42;icd;isocitrate dehydrogenase (NADP);-0.29934319451161784;-0.08382953651781833;0.3252212316803309;-0.7031831375505;-0.40383994303888215
HELO_3063A;58.23960312738882;51.56809812671714;40.58406754074943;35.813946286749264;41.23174300030817;31.455631741545233;4.053335130660698;4.654252838755336;7.4189375287031165;10.133170445467934;5.692759619513586;2.02399934150453;rluE;ribosomal large subunit pseudouridine synthase RluE;COG1187;Pseudouridylate synthase RsuA, specific for 16S rRNA U516 and 23S rRNA U2605;RsuA;HELO_RS11400;J;rluE; ribosomal large subunit pseudouridine synthase RluE;5.4.99.20;rluE;ribosomal large subunit pseudouridine synthase RluE;0.17237443514036688;0.35756204396426927;0.3798589534987613;0.8680931372170075;0.6957187020766407
HELO_3065;124.90568396908736;133.27546302043044;159.9545194461224;164.5538908337038;182.93872880775652;166.80674005169962;4.18568212754811;3.6413433304464613;4.352863866022525;2.733082319908059;8.883919812768914;5.314122688338591;mnmA;tRNA-specific 2-thiouridylase MnmA;COG0482;tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain;MnmA;HELO_RS11410;J;mnmA; tRNA-specific 2-thiouridylase MnmA;2.8.1.13;mnmA;tRNA-specific 2-thiouridylase MnmA;-0.09285228182778393;-0.060147576740068764;0.1324246115660772;-0.4144572490940055;-0.32160496726622156
HELO_3066;111.92686825815507;87.81500419402845;86.38554796515258;93.96648291163451;121.2005876518998;99.2543971033419;8.975727764131095;4.7328363556786295;3.3757422564209314;1.9583090225613549;4.573808304026663;10.989657548757647;HELO_3066;HflD family protein;COG2915;Regulator of phage lambda lysogenization HflD, binds to CII and stimulates its degradation;HflD;HELO_RS11415;TX;;mnmA;;HELO_3066;HflD family protein;0.34651345414773527;-0.19819890574285015;0.2855857090792817;0.17172326798125503;-0.17479018616648023
HELO_3067;189.14189277100286;142.7311544421635;251.32072909773845;247.5648179523852;338.3674599794803;266.4510423627542;12.723761030760853;1.2627478202840041;15.183594818766391;18.457248599009628;17.3492655409848;10.989928731775072;purB;adenylosuccinate lyase;COG0015;Adenylosuccinate lyase;PurB;HELO_RS11420;F;purB; adenylosuccinate lyase;4.3.2.2;purB;adenylosuccinate lyase;0.40370361994773063;-0.08401609243805286;0.34357341321934776;-0.4921983994896122;-0.8959020194373428
HELO_3068;46.87036509560187;64.97324516792423;109.77749427812375;90.4941383585264;112.9344619642127;107.58688507666926;3.1545356977384267;5.390432141288521;6.549944274447197;2.8022091822164685;7.776118110529877;1.2900589775536286;roxA;50S ribosomal protein L16 arginine hydroxylase;COG2850;Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain;RoxA;HELO_RS11425;J;roxA; 50S ribosomal protein L16 arginine hydroxylase;1.14.11.47;roxA;50S ribosomal protein L16 arginine hydroxylase;-0.462748262420857;0.028814943445421015;0.06935432002857755;-1.181645153327218;-0.7188968909063611
HELO_3069;40.12720797280799;48.59939550947026;58.21278556803188;39.916880035247665;55.74726793659294;57.620352568917866;2.959090824623744;4.731532441029063;1.0949286052957539;1.79003026138681;2.149482208872855;4.474854010642144;HELO_3069;GNAT family acetyltransferase;COG2153;Predicted N-acyltransferase, GNAT family;ElaA;HELO_RS11430;R;;roxA;;HELO_3069;GNAT family acetyltransferase;-0.2702294038670363;0.014507079506187459;-0.046850708682042885;-0.5113085109966793;-0.24107910712964298
HELO_3070;13.474071779748918;2.8271204937187817;10.321255177412722;21.086678319025722;8280.64387002979;9.708707250720304;0.5724545889886503;0.23811873622375096;1.240556756793001;6.5876196307172545;193.3022135548296;1.3538438263733363;aceA;isocitrate lyase;COG2224;Isocitrate lyase;AceA;HELO_RS11435;C;aceA; isocitrate lyase;4.1.3.1;aceA;isocitrate lyase;1.9191396024521357;0.08024958809938676;9.594989025326587;0.43468650210089343;-1.4844531003512422
HELO_3071;224.33897725754454;8.206350926667925;41.828734447163406;80.63999717178744;4771.085984724041;26.887386355578016;29.594695139304815;2.6235266678992755;6.971300780310327;24.447834551504645;609.3342751071223;7.897531897851774;HELO_3071;uncharacterized protein;;;;;;;;;HELO_3071;uncharacterized protein;4.613323634192368;0.6189663181147536;7.418863498580686;3.01441224607796;-1.5989113881144084
HELO_3072;1808.9492394497936;568.830902021435;1869.9285895374007;1511.7587003245665;1501.2713979447035;1766.52545001198;58.43639570031736;48.694284371891484;106.52284777131602;109.85340449827699;196.80063413046622;225.67909783621585;slyB;outer membrane lipoprotein SlyB;COG3133;Outer membrane lipoprotein SlyB;SlyB;HELO_RS11445;M;slyB; outer membrane lipoprotein SlyB;;slyB;outer membrane lipoprotein SlyB;1.667343470595986;0.08202350611090914;-0.2345855166975923;0.03421824900489234;-1.6331252215910936
HELO_3073;430.7434111438481;333.8409237486522;371.16426504038645;299.0923452796798;313.31585145108505;334.4640649956811;50.89843011070493;29.558959058902467;12.36870858545285;15.063330635635761;21.158161275416443;21.06190614422212;HELO_3073;uncharacterized protein;;;;;;;;;HELO_3073;uncharacterized protein;0.36669829822773004;0.14978130264412215;-0.09394320141688084;0.3640159280799935;-0.0026823701477365347
HELO_3074;712.1304295739275;815.8631003576764;1287.335512330524;991.7478457690435;757.2475619063354;1124.8733380837582;91.53215086779028;126.66989644596245;87.00590538047614;105.04217039646632;74.81612223902401;87.48264304147081;slyD1;FKBP-type peptidyl-prolyl cis-trans isomerase SlyD;COG1047;Peptidyl-prolyl cis-trans isomerase, FKBP type;SlpA;HELO_RS11455;O;slyD1; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD;5.2.1.8;slyD1;FKBP-type peptidyl-prolyl cis-trans isomerase SlyD;-0.195928348904161;0.19446382163938303;-0.5703036727799642;-0.6588066610324912;-0.4628783121283302
HELO_3075;28.7888403244806;11.676672766163023;20.603653109036106;29.301664841803916;27.137343067172534;22.57800393354484;2.9787956147514842;0.8203623019367073;0.9054979845907447;1.7197114475200286;1.0086488512693448;1.710022641848142;ynjF;YnjF family protein;COG0558;Phosphatidylglycerophosphate synthase;PgsA;HELO_RS11460;I;ynjF; YnjF family protein;;ynjF;YnjF family protein;1.2325958283447398;-0.12616629966244464;0.2550445174116902;0.3373303729352477;-0.8952654554094921
HELO_3076;25.106675879797667;5.414055367624218;11.154510760701124;17.46290208609531;15.564079996546775;10.859546984045869;2.6432026014968772;0.07737561204077746;1.3958790571222046;0.5075678080116149;2.823295336324629;2.7692623442313695;msrA2;peptide methionine sulfoxide reductase MsrA (S-form specific);COG0225;Peptide methionine sulfoxide reductase MsrA;MsrA;HELO_RS11465;O;msrA2; peptide methionine sulfoxide reductase MsrA (S-form specific);1.8.4.11;msrA2;peptide methionine sulfoxide reductase MsrA (S-form specific);2.025110060725776;0.035442921391805715;0.48200917309540525;1.1383698710866916;-0.8867401896390845
HELO_3077;18.076550807285457;12.244613210354677;12.27761811151467;19.720385179611338;19.050005318482906;10.84548194115188;0.9484597290605442;0.9418184832017255;1.4848075506294875;0.4411488610916661;1.0567453110157212;0.17117953639034691;HELO_3077;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS11470;G;;msrA2;;HELO_3077;major facilitator superfamily transport protein;0.5263946316245023;0.16465946627172778;0.7592657226107549;0.6874634473789372;0.16106881575443488
HELO_3078;17.95500222430346;17.33994843725507;20.054930250042087;18.438000511402375;18.144010658201385;21.99399892718687;1.4496158711487284;0.6062579553904933;2.317158665035819;0.9939529137093915;1.3795856101535353;1.488514367550706;HELO_3078;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS11475;K;;;;HELO_3078;LysR family transcription regulator;0.04758904300065936;-0.12709929332190395;-0.26436428433987746;-0.2786787637287391;-0.3262678067293985
HELO_3079;824.1232768645012;283.06736458701926;706.2317547040531;1141.9347297022925;1172.2757065970493;683.102338332243;43.69099641277608;5.721543397862501;35.09967872190535;55.50074106887953;211.04463447962257;54.68128580456634;HELO_3079;NlpC domain protein;COG0791;Cell wall-associated hydrolase, NlpC_P60 family;NlpC;HELO_RS11480;M;;;3.4.-.-,3.4.17.13;HELO_3079;NlpC domain protein;1.538376584795012;0.04797089187664483;0.7782580038927112;0.27039751881684815;-1.2679790659781638
HELO_3080;233.30347002113695;310.2382501882185;283.49093912628206;355.11535892503025;231.48089656655154;244.77753011481005;10.73378019902419;17.99714140085924;12.456328260862659;23.541784612680903;14.999440335179926;6.7410670694060615;HELO_3080;DUF1266 family protein;;;;;;;;;HELO_3080;DUF1266 family protein;-0.40964105324763533;0.21102967899556546;-0.08024085338378306;-0.06897470466477795;0.3406663485828574
HELO_3081;51.627574763736625;39.3299390056067;88.13434684750041;53.53757700515835;108.94666184763737;96.40918496797866;2.866207685206353;3.2209977015612443;7.160352734117694;4.401777017724705;2.7664205707418197;3.030727352435222;gabD1;succinate-semialdehyde dehydrogenase (NAD(P));COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS11490;I;gabD1; succinate-semialdehyde dehydrogenase (NAD(P));1.2.1.16,1.2.1.79,1.2.1.20;gabD1;succinate-semialdehyde dehydrogenase (NAD(P));0.38396768881905086;-0.12807635017730234;0.1746740830431559;-0.888238901573259;-1.2722065903923099
HELO_3082;149.1914766514063;107.83690905804947;213.77037816880224;158.8560469013845;337.0286996461569;232.97939067775005;8.276604707320327;2.1576225018042723;10.076699963031807;3.2531541421680172;13.117646090425255;22.446823415664316;gabT1;4-aminobutyrate aminotransferase;COG0160;Acetylornithine aminotransferase/4-aminobutyrate aminotransferase;ArgD;HELO_RS11495;E;gabT1; 4-aminobutyrate aminotransferase;2.6.1.19,2.6.1.22,2.6.1.48;gabT1;4-aminobutyrate aminotransferase;0.46463505231070545;-0.12358643441364947;0.5307642805740569;-0.639578517849527;-1.1042135701602325
HELO_3083;473.99852115775826;190.17586851635232;552.4120670599668;350.42908000403594;245.0527921631198;368.7150904850473;74.84250799458749;25.92534606065653;64.49707881942959;163.76239186502463;48.2366213251194;84.31277876785144;HELO_3083;UPF0410 family protein;COG2261;Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family;YeaQ;HELO_RS11500;R;;gabT1;;HELO_3083;UPF0410 family protein;1.3130225935261803;0.5819401714967558;-0.5874460425179411;0.361509091294554;-0.9515135022316263
HELO_3084;39.855179010225754;16.047715642591257;31.930098229555302;50.93049062726197;40.64490693743988;29.449598993585013;3.539292585407976;1.740431856948716;4.5940630727528085;2.5876840620392185;4.558188011194699;2.732350676540022;HELO_3084;DUF924 family protein;COG3803;Uncharacterized conserved protein, DUF924 family;;HELO_RS11505;S;;;;HELO_3084;DUF924 family protein;1.2609405391698116;0.11298358679391729;0.4517168399063616;0.4240957446581124;-0.8368447945116992
HELO_3085;335.31211207379323;462.6258624407067;461.0493774809153;531.5572175773231;41.83813604589037;503.0037561058936;26.84992765407444;1.86607417108829;43.175677183262124;70.61696576762382;3.0482636824351466;25.113335777134473;HELO_3085;SSS family transport protein;COG4146;Uncharacterized membrane permease YidK, sodium:solute symporter family;YidK;HELO_RS11510;R;;;;HELO_3085;SSS family transport protein;-0.46316030886977977;-0.12538745022290954;-3.556466872846081;-0.5836337479269087;-0.12047343905712893
HELO_3086;10.691565114281516;18.299262142718355;12.343376264325665;12.993340982573777;9.87107585533562;13.649058715055588;0.8465029430625386;1.6497585098059793;2.2796698966342888;0.9558661422574066;0.9831111828196043;0.9076238824578399;HELO_3086;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS11515;K;;;;HELO_3086;PfpI/HTH domain protein (homolog to transcription regulator CdhR);-0.7230776188439054;-0.13468420956258909;-0.43031324264860205;-0.3253398943057264;0.397737724538179
HELO_3087;8.790549434929988;7.7806560405638505;8.896115488844115;8.644531029233951;11.304998504201441;9.408490578567925;0.7817627976088909;0.8249699038987861;0.1584087608281765;1.0668348919002804;0.4810419793556741;0.6100136112701259;HELO_3087;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS11520;G;;;;HELO_3087;major facilitator superfamily transport protein;0.15706109083246433;-0.07282662470054824;0.24148361577339683;-0.08829913696652403;-0.24536022779898836
HELO_3088;102.4320141878926;23.24532543475678;51.33490184802448;73.03766099085904;70.13204605453156;60.577845663093285;10.905534974055811;2.1878116923357083;5.5064149780482134;1.9810592892752277;6.1201901648028745;8.393881110881876;HELO_3088;DUF463 family protein;COG3106;Ras-like GTP-binding stress-induced protein YcjX,  DUF463 family;YcjX;HELO_RS11525;T;;;;HELO_3088;DUF463 family protein;2.0929042728367744;-0.23463800219651976;0.20808826733198416;0.7481994966500558;-1.3447047761867186
HELO_3089;72.02050269454439;14.346963237997045;27.976628880466702;42.2042780711601;58.13740779564094;33.352479300455755;6.70852789698041;1.4980360298430204;2.8195059122284833;1.6349463085769227;3.1938814316832747;4.237940725120956;HELO_3089;UPF0283 family protein;COG3768;Uncharacterized membrane protein YcjF, UPF0283 family;YcjF;HELO_RS11530;S;;;;HELO_3089;UPF0283 family protein;2.2503483884635593;-0.24552446296149988;0.7836567808073172;1.087887375195705;-1.1624610132678543
HELO_3090;8.219083765043747;6.451671336001321;765.9103494846121;1629.349151651348;43.32633513739368;645.681311403744;0.303059807159125;0.3363935531331771;83.38360315432524;51.06046240908131;1.863997013741075;46.55597973654224;HELO_3090;DUF1479 family protein;;;;;;;;;HELO_3090;DUF1479 family protein;0.30705933204645053;0.24600302078564162;-3.866818926419974;-6.13228773186861;-6.4393470639150605
HELO_3091;6.959886788954017;6.563280406832519;935.2891821334857;1929.56859177576;38.98680882543828;733.6495132038717;0.1838712538306503;0.31562626827660534;138.61598566486362;158.9578404973832;2.3143031042996896;78.9032749782412;gtsD;ABC-type transport system ATP-binding protein (probable substrate glucose);COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS11540;G;gtsD; ABC-type transport system ATP-binding protein (probable substrate glucose);;gtsD;ABC-type transport system ATP-binding protein (probable substrate glucose);0.07373580441595484;0.34989805648072014;-4.199460077131604;-6.528164410596306;-6.60190021501226
HELO_3092;1.7707879851878197;1.6892466220607203;591.5986266491609;1188.3054521116226;11.865766457236083;524.6325911723904;0.15782132291231352;0.06849914046770829;84.46702428370176;168.2615447229255;1.3122437203189616;44.87826934524702;gtsC;ABC-type transport system permease protein (probable substrate glucose);COG0395;ABC-type glycerol-3-phosphate transport system, permease component;UgpE;HELO_RS11545;G;gtsC; ABC-type transport system permease protein (probable substrate glucose);;gtsC;ABC-type transport system permease protein (probable substrate glucose);0.0430942569344801;0.17300055196575137;-5.3524454199138845;-7.567614597575731;-7.610708854510211
HELO_3093;3.362934791492881;3.0659078763696663;842.2865365798067;1707.8305067700176;12.623007207135828;758.393470972126;0.6311982944479253;0.32241000495098715;112.82345643849762;153.05903011590783;0.9444151813273055;59.23125081258091;gtsB;ABC-type transport system permease protein (probable substrate glucose);COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS11550;G;gtsB; ABC-type transport system permease protein (probable substrate glucose);;gtsB;ABC-type transport system permease protein (probable substrate glucose);0.10172138375219175;0.15117532622810614;-5.800730484214581;-7.443404873615917;-7.545126257368109
HELO_3094;21.425873750770354;19.424555822106164;3441.530790540044;8691.884713922007;112.07769510868302;2844.6267422044907;1.0121012400115887;1.6074118701452282;388.38514921369443;805.0753556366989;7.7993349423757525;373.512520820313;gtsA;ABC-type transport system periplasmic substrate-binding protein (probable substrate glucose);COG1653;ABC-type glycerol-3-phosphate transport system, periplasmic component;UgpB;HELO_RS11555;G;gtsA; ABC-type transport system periplasmic substrate-binding protein (probable substrate glucose);;gtsA;ABC-type transport system periplasmic substrate-binding protein (probable substrate glucose);0.13485949206553638;0.2747231205913163;-4.653360150643911;-6.987438431164175;-7.122297923229711
HELO_3095;34.85642361127111;25.2857485122888;118.1846390806714;147.35644359510468;275.29321018093907;123.16837694321553;1.8986287019382657;0.5483518696459905;11.355659140451811;8.98997690855272;9.059088582637147;0.7527344622120989;HELO_3095;glycosidase domain protein;COG2942;Mannose or cellobiose epimerase, N-acyl-D-glucosamine 2-epimerase family;YihS;HELO_RS11560;G;;gtsA;;HELO_3095;glycosidase domain protein;0.4479507805598919;-0.059099488089308316;1.1539023123524768;-1.791994293141408;-2.2399450737013
HELO_3096;27.367008623891348;16.79585746146766;36.41603222785768;47.46780058927072;76.37589378358763;36.36553085216706;5.821713285911232;0.793849066079302;3.6772795137725036;2.333745510917201;1.6245466657403833;4.9723883192942315;gtrS;sensor histidine kinase GtrS;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS11565;T;gtrS; sensor histidine kinase GtrS;;gtrS;sensor histidine kinase GtrS;0.6726725744294164;0.001948557701708431;1.0501761504498477;-0.3974939961923134;-1.0701665706217298
HELO_3097;137.39162642704179;93.11263549435266;212.69245822658468;244.84111098389045;362.57498168287253;216.7711985560767;19.237474883314793;8.381918496524513;15.663047710936207;11.197675245825025;29.113300935167423;29.048134026219927;gltR;response regulator/HTH domain transcription regulator GltR;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS11570;KT;gltR; response regulator/HTH domain transcription regulator GltR;;gltR;response regulator/HTH domain transcription regulator GltR;0.5562963171335298;-0.027277169919755373;0.7394397659513334;-0.6540565088866686;-1.2103528260201983
HELO_3098;119.46724666607496;89.48128446584663;177.63982102657667;202.55863307734705;177.1704499232773;169.34409611146438;5.152499446143559;2.1409441583835442;7.760911412420125;3.9931202436289737;15.709760861158182;6.4593603779626925;HELO_3098;HAD superfamily hydrolase;COG0561;Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases;Cof;HELO_RS11575;HR;;gltR;;HELO_3098;HAD superfamily hydrolase;0.4129496364898868;0.06860176437961574;0.06480613511221733;-0.4998109950336147;-0.9127606315235015
HELO_3099;21.58882640674376;38.003865931466514;97.74625517350006;81.61818828075782;77.07944253567292;99.18327224642142;1.1510934115977918;1.316605376322383;5.515668317215282;6.909081202942839;2.8246891950499817;8.357300804726997;nagE;phosphotransferase system component EIICB%2C N-acetylglucosamine-specific;COG1264;Phosphotransferase system IIB components;PtsG2;HELO_RS11580;G;nagE; phosphotransferase system component EIICB, N-acetylglucosamine-specific;2.7.1.193;nagE;phosphotransferase system component EIICB%2C N-acetylglucosamine-specific;-0.7880078080760624;-0.02084369770568717;-0.3596269820224052;-2.1489604164943357;-1.3609526084182733
HELO_3100;24.596339697080793;38.99007893928039;104.43493771151127;83.18559322115952;87.80402609898965;103.1827156529419;0.13217471738210387;0.43146412182894706;6.047952833932409;2.191325716848244;3.2259114267390445;11.434545377186666;nagF;multiphosphoryl transfer protein%2C N-acetylglucosamine-specific;COG2190;Phosphotransferase system IIA component;NagE;HELO_RS11585;G;nagF; multiphosphoryl transfer protein, N-acetylglucosamine-specific;2.7.3.9,2.7.1.202;nagF;multiphosphoryl transfer protein%2C N-acetylglucosamine-specific;-0.643704610890584;0.01723706010167625;-0.23041895785687316;-2.0251065251322204;-1.3814019142416365
HELO_3101;27.85719481941479;37.05579435936895;82.24614107802547;62.66081024722064;65.32824790204735;79.50008571899745;1.6151115799712241;1.7264471551547436;3.258946748273504;7.922918139118138;2.9009521428646785;9.484540836306866;HELO_3101;SIS domain protein;COG2222;Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain;AgaS;HELO_RS11590;M;;nagF;2.6.1.16;HELO_3101;SIS domain protein;-0.39918507097221756;0.048393077334274004;-0.2793669026765082;-1.4800592558284738;-1.0808741848562562
HELO_3102;24.142925438606238;29.482298484792853;57.0702974141149;40.67311126115023;35.640623759868994;55.601995799872476;2.6378239317161722;1.5510815093614245;3.779596015753854;7.728630371455796;2.0671714595768957;2.1477375183675185;nagA;N-acetylglucosamine-6-phosphate deacetylase;COG1820;N-acetylglucosamine-6-phosphate deacetylase;NagA;HELO_RS11595;G;nagA; N-acetylglucosamine-6-phosphate deacetylase;3.5.1.25;nagA;N-acetylglucosamine-6-phosphate deacetylase;-0.2778191713027436;0.036947499272968365;-0.6274088600390506;-1.1707004032338872;-0.8928812319311437
HELO_3103;23.628373208235757;18.141758204837473;59.99851055336554;41.43595034812217;39.99624052086557;57.04023484229217;1.7925105329009983;1.2657622353266413;4.956262481684811;2.01644095249321;10.04994687310323;6.5353245108498665;HELO_3103;HutC family transcription regulator;COG2188;DNA-binding transcriptional regulator, GntR family;MngR;HELO_RS11600;K;;nagA;;HELO_3103;HutC family transcription regulator;0.36359798580012637;0.07172065888627;-0.501561740544676;-1.2367320210080814;-1.6003300068082078
HELO_3104;252.90617251999;279.9101999486275;343.74413198185295;282.64798309502936;321.3516289343808;376.38435376815477;6.8247486703292894;1.9821878523350822;21.048073135156002;6.6565266754867665;21.55296483984858;15.542706689698228;rnb;exoribonuclease 2;COG4776;Exoribonuclease II;Rnb;HELO_RS11605;K;rnb; exoribonuclease 2;3.1.13.1;rnb;exoribonuclease 2;-0.1458135425077245;-0.13050861521469592;-0.22739933666056444;-0.5717391428394212;-0.4259256003316967
HELO_3105;11.448532468522918;5.107585678875065;4.6538998991042435;5.683379261506018;5.546516327547633;4.836119290451021;1.1512390598926703;0.37835158045560285;0.019808561540866975;0.29511379447478653;0.9932203665974618;1.0156360132286477;HELO_3105;probable glycosyltransferase%2C type 1;COG0438;Glycosyltransferase involved in cell wall bisynthesis;RfaB;HELO_RS11610;M;;rnb;2.4.1.-;HELO_3105;probable glycosyltransferase%2C type 1;1.0273015737481703;-0.04576303144928273;0.16571802077996622;1.0928943986150377;0.06559282486686735
HELO_3106;4.99776359854358;1.9270273470764752;2.2282559954178107;2.9613352560245385;3.8243076883887865;3.4052828864859195;0.2477765604177823;0.2764484789315182;0.18825209400245543;0.3392370286681619;0.16281743305419946;0.36078644928503883;HELO_3106;glycosyltransferase domain protein;;;;;;;;;HELO_3106;glycosyltransferase domain protein;1.034988434757057;-0.4484796786823737;0.1310872582908158;0.44518999440717266;-0.5897984403498844
HELO_3107;4.973150466518409;10.632293423173873;6.333118020380152;7.1436496310904;6.26407376252529;6.344896992214841;0.40440747850793013;0.1096644966952218;0.34915472130737324;0.7244610169531648;0.5209690502913135;0.5584593156202653;HELO_3107;SSS family transport protein;COG0591;Na+/proline symporter;PutP;HELO_RS11620;E;;;;HELO_3107;SSS family transport protein;-0.9615715971061087;-0.002315499457655079;-0.015963405540417863;-0.29825019357305704;0.6633214035330517
HELO_3108;1875.1704373741832;2919.164724164059;2225.682928997856;1417.559682864359;2522.8041881603344;2244.7145622728244;107.43764484039664;243.7295794610487;69.11468612590137;151.48045991058044;60.956983286464556;53.94459981154547;sucD;succinate--CoA ligase alpha subunit;COG0074;Succinyl-CoA synthetase, alpha subunit;SucD;HELO_RS11625;C;sucD; succinate--CoA ligase alpha subunit;6.2.1.5;sucD;succinate--CoA ligase alpha subunit;-0.638258859800267;-0.012278429513939315;0.16842541364993835;-0.25938367521586514;0.37887518458440184
HELO_3109;1436.3700116744221;1890.2128257986808;2521.08793665884;1524.7532676556245;3108.710863553913;2583.6955361337837;43.846821843059196;104.07526960987482;219.88646266419627;205.6450142896128;296.2321697427116;146.94738742440487;sucC;succinate--CoA ligase beta subunit;COG0045;Succinyl-CoA synthetase, beta subunit;SucC;HELO_RS11630;C;sucC; succinate--CoA ligase beta subunit;6.2.1.5;sucC;succinate--CoA ligase beta subunit;-0.39588023264634487;-0.03537577004872894;0.2667860984019246;-0.846562856416071;-0.4506826237697261
HELO_3110;966.3469579539766;1266.771451355189;1161.3919459715437;811.1249174731253;1547.6523860538225;1122.7004009318757;19.160447731363963;54.58307332585045;30.409226511372776;14.381882924421893;90.05829680017594;54.969235211542234;lpd;dihydrolipoate dehydrogenase;COG1249;Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase;Lpd;HELO_RS11635;C;lpd; dihydrolipoate dehydrogenase;1.8.1.4;lpd;dihydrolipoate dehydrogenase;-0.39018934726644083;0.048839173957535564;0.46275591198362775;-0.21615209945824887;0.17403724780819196
HELO_3111;572.4019262727269;873.7325232390689;808.719686484831;620.8676565093219;1266.2531486133694;793.5252548301486;17.749238526945934;32.99045819939156;7.61656522236706;15.394880494582;15.94823251575839;24.9215898150082;sucB;2-oxoglutarate dehydrogenase component E2;COG0508;Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component;AceF;HELO_RS11640;C;sucB; 2-oxoglutarate dehydrogenase component E2;2.3.1.61;sucB;2-oxoglutarate dehydrogenase component E2;-0.6092951842156165;0.027329475888512533;0.6735397654362654;-0.47054632675689056;0.1387488574587259
HELO_3112;443.01535517015344;703.1780565485527;947.2167955578328;827.2783218548319;1472.8023623656227;945.3917927221482;18.296035595856868;43.298173498842516;85.16783667969213;56.43347330083161;143.43281869876003;101.29991908290205;sucA;2-oxoglutarate dehydrogenase component E1;COG0567;2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes;SucA;HELO_RS11645;C;sucA; 2-oxoglutarate dehydrogenase component E1;1.2.4.2;sucA;2-oxoglutarate dehydrogenase component E1;-0.6653307014669902;0.002779385009944235;0.6390336037400264;-1.0918279929550874;-0.4264972914880971
HELO_3113;642.9186817628683;932.3529024714279;1055.16976444551;1122.0679523353565;1533.2498274874958;1025.7924658590807;20.899065582493048;44.955044688470096;108.1047265493727;81.00721310238208;34.29159607491511;111.92845424349625;sdhB;succinate dehydrogenase iron-sulfur subunit;COG0479;Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit;SdhB/FrdB;HELO_RS11650;C;sdhB; succinate dehydrogenase iron-sulfur subunit;1.3.5.1,1.3.5.4;sdhB;succinate dehydrogenase iron-sulfur subunit;-0.5355441629758584;0.04069713106833639;0.5793888060394323;-0.6731942031706524;-0.137650040194794
HELO_3114;518.1759348614331;729.1992102497238;1039.924944507754;1056.168443827246;1734.88979609566;1016.6659725857262;26.007421226973573;45.041754693387254;141.6288853838972;97.09776244061128;119.65592577486882;170.36478224393366;sdhA;succinate dehydrogenase flavoprotein subunit;COG1053;Succinate dehydrogenase/fumarate reductase, flavoprotein subunit;SdhA;HELO_RS11655;C;sdhA; succinate dehydrogenase flavoprotein subunit;1.3.5.1,1.3.5.4;sdhA;succinate dehydrogenase flavoprotein subunit;-0.49206659615544623;0.03260194255774174;0.7704112555537357;-0.9709686874819798;-0.4789020913265336
HELO_3115;536.5977162434632;734.7673339284785;358.32749418228747;339.7365182390266;520.3594648128782;400.0947762083957;26.04641585269164;38.21822743185718;96.6492216911504;65.53438574509268;178.35502531675945;96.14543997446576;sdhD;succinate dehydrogenase membrane anchor subunit;COG2142;Succinate dehydrogenase, hydrophobic anchor subunit;SdhD;HELO_RS11660;C;sdhD; succinate dehydrogenase membrane anchor subunit;;sdhD;succinate dehydrogenase membrane anchor subunit;-0.4527226165408287;-0.15864384852025104;0.37833524225436754;0.422583832595258;0.8753064491360867
HELO_3116;1098.1026114772121;2014.7107238001583;1731.824544315553;1683.5859458006037;2285.43607802668;1697.361721756403;106.01826881375325;507.70944940593074;373.1947422386237;128.39681887004855;548.6387890948785;268.7367558430249;sdhC;succinate dehydrogenase cytochrome b subunit;COG2009;Succinate dehydrogenase/fumarate reductase, cytochrome b subunit;SdhC;HELO_RS11665;C;sdhC; succinate dehydrogenase cytochrome b subunit;;sdhC;succinate dehydrogenase cytochrome b subunit;-0.8749625298062931;0.028981822246523237;0.4289568254532252;-0.6278176791707253;0.2471448506355678
HELO_3117;1041.8992441815635;851.1219083296573;1016.4068634959989;919.9703772953541;2589.821288517857;1016.0947428567366;53.41352243727263;5.16112160693431;44.379163040429866;92.02824520409045;88.49256127350465;87.81223757813159;gltA;citrate synthase;COG0372;Citrate synthase;GltA;HELO_RS11670;C;gltA; citrate synthase;2.3.3.1;gltA;citrate synthase;0.2914680353290393;0.00044265868412196596;1.3489554305420164;0.03614571081189588;-0.25532232451714343
HELO_3118;56.681178698112554;52.202109985129475;152.21440635607598;183.38265014117792;242.7023032462706;160.01944321130983;3.047425172193483;0.8325700941946398;5.463290627614235;23.159664066673834;12.151504585019081;14.713070252115763;HELO_3118;6-phosphogluconate dehydrogenase (decarboxylating);COG2084;3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase;MmsB;HELO_RS11675;I;;gltA;;HELO_3118;6-phosphogluconate dehydrogenase (decarboxylating);0.11661718207330285;-0.07168294876168968;0.5978849808280575;-1.4810623542558021;-1.597679536329105
HELO_3119;302.98220363180684;171.4117986003398;257.1766386749975;271.17717433745844;220.8457696209707;235.3920388326069;15.11085689542407;15.100537046847585;15.094615553547387;7.125562611378284;14.538926040650695;14.073489389389309;gltX;glutamate--tRNA ligase;COG0008;Glutamyl- or glutaminyl-tRNA synthetase;GlnS;HELO_RS11690;J;gltX; glutamate--tRNA ligase;6.1.1.17;gltX;glutamate--tRNA ligase;0.8181283595568738;0.12717701358967393;-0.0916244068612535;0.36280541532434807;-0.45532294423252573
HELO_3120;627.6548728624072;167.20593249871573;304.35949487911483;468.4661255626175;201.09979984559195;283.39090772613247;21.975227197087047;6.689432739199267;41.7231156574902;48.74872747459411;19.88906041861358;23.93305655292083;HELO_3120;uncharacterized protein;;;;;;;;;HELO_3120;uncharacterized protein;1.9020396156495663;0.10263336395476763;-0.49280744831926704;1.1443928636961882;-0.757646751953378
HELO_3121;1381.2790907380313;387.334917617882;624.6910545746689;1168.7652267459896;258.47367166317764;701.8653052832111;132.6121351753566;2.6876477689126617;41.47722411593668;24.19108457903798;28.930688476256204;110.16402180344623;HELO_3121;CBS domain protein;;;;;;;;;HELO_3121;CBS domain protein;1.83167559431722;-0.1677977644569122;-1.4376600843316503;0.9757287865035096;-0.8559468078137105
HELO_3122;99.63099472466388;140.79714426747714;117.55493334802456;127.07569452940197;126.23577029078793;115.63325789571614;2.9429189632468;1.1176045066697207;4.334721527074766;7.609758458956762;9.958723796155242;5.749421668720776;dusA;tRNA-dihydrouridine(20/20a) synthase DusA;COG0042;tRNA-dihydrouridine synthase;DusA;HELO_RS11705;J;dusA; tRNA-dihydrouridine(20/20a) synthase DusA;1.-.-.-;dusA;tRNA-dihydrouridine(20/20a) synthase DusA;-0.49475374853731147;0.023576467252182987;0.1255250874255749;-0.2129045016463289;0.28184924689098256
HELO_3123;127.01075066335538;16.35156962643789;70.0669025754584;87.40899304928341;76.79623564169462;70.92487967797689;2.422891029972392;1.1223396662797445;6.312225841922876;3.0487302628675117;9.938614795477303;4.769289874226783;HELO_3123;uncharacterized protein;COG3608;Predicted deacylase;;HELO_RS11710;R;;dusA;;HELO_3123;uncharacterized protein;2.8831268961554812;-0.017313081162004806;0.11320944612044759;0.8317021688381265;-2.0514247273173547
HELO_3124;68.45170460568333;50.96926257930329;88.85759968013207;101.1936967246099;120.94241524662363;93.9416531196619;1.340408408788643;2.446280034511276;4.947027042232585;6.449105906074237;9.100923423728734;5.816992574663586;HELO_3124;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS11715;K;;;;HELO_3124;TetR family transcription regulator;0.41835151584532326;-0.0794006457201295;0.3610869508225907;-0.4510310663290955;-0.8693825821744188
HELO_3125;56.68409491303066;5.377852468817899;40.50661051974809;76.84290966354847;62.382065285158404;37.35858789998735;3.642506673227292;0.9474590481468613;7.78423719606544;0.1740686654918371;13.170780471933947;0.8559253282081696;HELO_3125;uncharacterized protein;;;;;;;;;HELO_3125;uncharacterized protein;3.177030952151058;0.11379151332036486;0.7245250590603982;0.5886239719113888;-2.588406980239669
HELO_3126;276.54313116718095;152.10265651372393;216.7055818344717;193.0705644769688;169.84847213962263;207.24594135326853;25.19990346905287;6.328518528052769;7.893634469309073;5.153456103742699;11.16542925439355;11.9201676009055;HELO_3126;HAE1 family transport protein;COG0841;Multidrug efflux pump subunit AcrB;AcrB;HELO_RS11725;V;;;;HELO_3126;HAE1 family transport protein;0.8582126731738882;0.06409001959531935;-0.2855710320804672;0.41442361050836496;-0.4437890626655232
HELO_3127;322.28313116792117;169.9556205519864;204.70518482412058;155.38980545127785;182.25945621861422;201.30904008213176;16.49297059974523;9.025821833857853;18.54245283201286;6.453767919179365;22.271280613091015;24.239715576793788;HELO_3127;RND family transport protein MFP component;COG0845;Multidrug efflux pump subunit AcrA (membrane-fusion protein);AcrA;HELO_RS11730;VM;;;;HELO_3127;RND family transport protein MFP component;0.9191763745577175;0.024017370154098217;-0.14267314388504637;0.6762374424949238;-0.2429389320627937
HELO_3128;344.9478422981005;183.185028032045;287.06232079829505;249.03877778844094;306.559415934526;307.8022546005349;2.64950542539402;2.6021383547112675;18.68742674767285;8.247752506382943;24.738693203865928;20.740173077908526;HELO_3128;homolog to outer membrane protein TolC;COG1538;Outer membrane protein TolC;TolC;HELO_RS11735;M;;;;HELO_3128;homolog to outer membrane protein TolC;0.9093987497814977;-0.10030232085477842;-0.005818141185313763;0.16387125676273406;-0.7455274930187636
HELO_3129;41.07128448510591;11.61619407593193;39.2287826280133;67.01324591914272;48.48289504035038;34.117864673863295;0.3694909096763279;0.2816518177115419;6.076504092172785;9.995666025483786;7.807052479715667;0.770229779016785;HELO_3129;alpha/beta hydrolase fold protein;COG0596;2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold;MenH;HELO_RS11740;HR;;;;HELO_3129;alpha/beta hydrolase fold protein;1.737559107425792;0.19602295580398188;0.4947247838172988;0.2606307408217772;-1.4769283666040147
HELO_3130;75.81392827031318;111.69714338089248;99.980190845628;134.18889712826444;119.25844464604454;87.73360824757386;1.261474930466468;9.584580692815232;2.4427755941840297;17.090266009787904;4.970563523326239;5.802206495954057;HELO_3130;kinase domain protein;COG3001;Fructosamine-3-kinase;FN3K;HELO_RS11745;G;;;;HELO_3130;kinase domain protein;-0.5530111107280762;0.1865197688091147;0.43858566448490155;-0.20811270411856864;0.34489840660950755
HELO_3131;25.014193548466164;22.453993277945063;42.92284411946298;44.280787771638266;51.05764175424178;43.39875641436954;2.6811978749366085;3.9006811535815946;5.7373253991020645;4.19563284366102;5.447217670080237;3.4707997542691316;HELO_3131;uncharacterized protein;COG3323;PII-like insert in the uncharacterized protein YqfO, YbgI/NIF3 family;YqfO;HELO_RS11750;S;;;;HELO_3131;uncharacterized protein;0.1494654068458976;-0.015547792358955093;0.22959069016042744;-0.7712202841960822;-0.9206856910419798
HELO_3132;127.23572614313441;142.59949387695278;239.188654873901;307.53429375556726;236.6451594615937;225.34785310496454;6.666396270368792;6.575816611435498;11.729503453259161;18.89481758082332;6.688703591147034;7.652986183860727;HELO_3132;NUDIX family hydrolase;COG1051;ADP-ribose pyrophosphatase YjhB, NUDIX family;YjhB;HELO_RS11755;F;;;;HELO_3132;NUDIX family hydrolase;-0.1632524152452115;0.08562638528425026;0.0702673932436122;-0.8197433737002342;-0.6564909584550227
HELO_3133;123.98530056704415;41.558547954817854;95.04646473431991;75.02727386878101;81.14582166384855;92.1439230991743;4.590992926986102;2.890279094997595;9.635987015490228;9.259372963352403;9.114662159327228;6.671880225274818;HELO_3133;NUDIX family hydrolase;COG0494;8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family;MutT;HELO_RS11760;V;;;;HELO_3133;NUDIX family hydrolase;1.5542375967035902;0.04427086448818773;-0.18127445329728964;0.4242248775564237;-1.1300127191471665
HELO_3134;156.55038971538985;34.772520120559655;83.61065643180916;68.7968469573528;72.73917148354205;76.3335738299093;15.302526780623701;3.1998011743380914;6.093834964221139;6.694113625719991;0.1882965572868883;3.7158084579037793;HELO_3134;hydroxylase domain protein;COG3751;Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain;EGL9;HELO_RS11765;JO;;;;HELO_3134;hydroxylase domain protein;2.138889660264166;0.129744491343045;-0.06866367937397655;1.0266465317807913;-1.1122431284833745
HELO_3135;164.97239738773249;122.42896566342917;286.76402158595954;341.49707814645194;316.0960685106684;271.1308463517542;5.4322553791572945;2.6444247585185;12.783170953353544;2.387017281200686;32.339633830226624;20.500675640357876;HELO_3135;MOSC domain protein;COG3217;N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain;YcbX;HELO_RS11770;VF;;;;HELO_3135;MOSC domain protein;0.427262330805803;0.08058572977235734;0.22061949338013775;-0.7133571678932675;-1.1406194986990705
HELO_3136;83.08857378792781;37.933709549285226;98.71406157210804;114.5300385423199;163.0367521359241;85.64614034048799;1.3491658697945257;1.4154939798830535;4.429145554862114;1.2757588819332868;25.818347352940467;10.926147538278668;ygeA;YgeA family protein;COG1794;Amino acid racemase YgeA;RacX;HELO_RS11775;M;ygeA; YgeA family protein;5.1.1.13;ygeA;YgeA family protein;1.1108899667968304;0.20266148046095278;0.9208116932991803;-0.04322570985383756;-1.154115676650668
HELO_3137;88.09411215215363;109.97008512937445;137.07881085089963;151.9812632346541;191.8903557666931;134.87287554231906;7.057183919704844;11.09207105215295;11.233761649415612;16.945551199296215;33.63083808446686;11.381278623936907;HELO_3137;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS11780;J;;ygeA;;HELO_3137;GNAT family acetyltransferase;-0.3167688145614651;0.023234467056499675;0.5055235345793578;-0.6088554795056353;-0.29208666494417024
HELO_3138;254.54863504534214;145.6436473249631;393.813899786207;287.3698019487103;904.6889698216586;405.56300399599803;26.48948711555662;8.053679236841752;11.955362258862468;9.226367970408528;21.002102667879285;21.349982185219638;crt;short-chain-enoyl-CoA hydratase;COG1024;Enoyl-CoA hydratase/carnithine racemase;CaiD;HELO_RS11785;I;crt; short-chain-enoyl-CoA hydratase;4.2.1.17;crt;short-chain-enoyl-CoA hydratase;0.8012833113439708;-0.04230615817577821;1.1555367471584557;-0.6698810547363498;-1.4711643660803206
HELO_3139;366.879862970622;162.93903328616588;529.7136298203227;449.03054156719577;1037.7945679756128;475.4810149553194;32.6119879667991;12.851734709602928;23.101450841197977;30.13891536781055;47.39472374096659;17.118822180430488;HELO_3139;acyl-CoA dehydrogenase family protein;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS11790;I;;crt;1.3.8.-;HELO_3139;acyl-CoA dehydrogenase family protein;1.1660753123802463;0.15551486847869533;1.1244197378208778;-0.3731840239831179;-1.5392593363633642
HELO_3140;157.23017904571608;53.141049583876104;53.984772917776134;56.97260144871624;54.51273374800079;52.09269699640794;9.716090934229383;2.0006238564048933;2.769644154766906;1.491889622772006;0.5062081967883073;4.4823221479201285;HELO_3140;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS11795;G;;;;HELO_3140;major facilitator superfamily transport protein;1.547230028320933;0.05051871532827068;0.0643053118035466;1.575439455205749;0.02820942688481587
HELO_3141;45.919758520462615;36.400220315372;49.26822957892139;42.04090498955553;41.78719804874601;47.19698971084315;2.626414282285562;2.7240718400354194;10.673645642278508;3.940201795701358;2.498716426357784;2.524005696847733;HELO_3141;probable S-adenosylmethionine-dependent methyltransferase;;;;;;;;;HELO_3141;probable S-adenosylmethionine-dependent methyltransferase;0.3271488196455703;0.060703837578806485;-0.17176383527034922;-0.03874745303487792;-0.3658962726804482
HELO_3142;272.89855236702766;52.61830674900457;195.854303006765;160.00379045620113;212.98356669853035;215.6815302905228;19.40684974503591;5.589013054076515;22.158038273336913;7.616870680521906;3.6582916065284743;5.814071932565659;HELO_3142;glyoxalase domain protein;COG0346;Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family;GloA;HELO_RS11805;Q;;;;HELO_3142;glyoxalase domain protein;2.352844075753154;-0.13844793635752772;-0.018076178647170593;0.33806545616378525;-2.014778619589369
HELO_3143;301.11998756957684;207.66552206331275;270.7626951773628;237.46105344567226;277.4743216581134;276.46032444437924;16.939690529840753;14.757600002759933;11.61415554910844;13.689226167974303;17.475182499113604;18.943249355523477;HELO_3143;DUF4870 domain protein;COG3671;Uncharacterized membrane protein;;HELO_RS11810;S;;;;HELO_3143;DUF4870 domain protein;0.5339293898662696;-0.02993405625402623;0.005262814196711929;0.12284014520997744;-0.41108924465629215
HELO_3144;203.9419870619646;118.81372853225137;143.99531686301611;141.71639797185912;154.1664664679314;148.79369172778485;12.619876561266263;5.197716400292919;11.179327201414333;5.656806430558974;12.290690822963082;11.127078278209767;HELO_3144;probable acyltransferase (homolog to lipid A biosynthesis lauroyl acyltransferase);COG1560;Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis);LpxP;HELO_RS11815;I;;;2.3.1.241,2.3.1.-;HELO_3144;probable acyltransferase (homolog to lipid A biosynthesis lauroyl acyltransferase);0.7744223588564934;-0.046970564709010176;0.05083993691265132;0.4522387150077085;-0.32218364384878484
HELO_3145;183.64892245044166;48.228316691360924;108.32552949451697;128.36956629591705;103.67507227905638;98.15006527467926;15.099947600166882;1.4843654378133666;7.9325495053513855;8.324535758641064;17.027514532859684;10.14294774529764;opgG;glucan biosynthesis protein OpgG;COG3131;Periplasmic glucan biosynthesis protein OpgG;MdoG;HELO_RS11820;M;opgG; glucan biosynthesis protein OpgG;;opgG;glucan biosynthesis protein OpgG;1.907224529336582;0.1409447084627109;0.07823228691794615;0.8970992161265539;-1.010125313210028
HELO_3146;157.96391053599686;31.569867990509252;93.16484269499864;89.59784822035282;88.85460071406139;87.27875986086777;12.208757611808654;1.3301467896351231;5.542587707778299;0.8871325920670168;14.077842608804971;9.371011567972792;opgH;glucan biosynthesis glucosyltransferase OpgH;COG2943;Membrane glycosyltransferase;MdoH;HELO_RS11825;MG;opgH; glucan biosynthesis glucosyltransferase OpgH;2.4.1.-;opgH;glucan biosynthesis glucosyltransferase OpgH;2.2870894912044673;0.09312215418775605;0.02552601136298005;0.8485610007436808;-1.4385284904607865
HELO_3147;108.00525068506481;108.37661494506877;299.8447914190226;383.6152080295954;326.03146397450524;305.1059123986647;10.408818236425715;10.467017625093977;17.216203587353245;15.694216726443518;34.31051833489148;10.925745100612327;HELO_3147;TenA family protein;COG0819;Aminopyrimidine aminohydrolase TenA (thiamine salvage pathway);TenA;HELO_RS11830;H;;opgH;3.5.99.2;HELO_3147;TenA family protein;-0.004906688485023736;-0.02501153127369804;0.09539853470020354;-1.4896332806132975;-1.4847265921282737
HELO_3148;122.07698819564412;240.30726816776473;285.11327166701875;281.27348133564254;301.8048851385562;292.58054550114633;12.833783086780384;6.646446653015934;14.785160242979149;4.84451817650918;9.505998672371804;43.36581075315523;thiC;phosphomethylpyrimidine synthase;COG0422;4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) synthase ThiC;ThiC;HELO_RS11835;H;thiC; phosphomethylpyrimidine synthase;4.1.99.17;thiC;phosphomethylpyrimidine synthase;-0.9713103249663018;-0.03716994912452343;0.04463211117554877;-1.254195324100981;-0.2828849991346791
HELO_3149;506.0914866483963;223.87349471322793;561.5677035916825;521.0802849695957;550.4408538225179;586.055865263236;18.334596575793448;8.667552998108006;47.84743062315864;24.084078334914935;60.5468498023155;53.793320597748135;HELO_3149;pyridoxal phosphate-dependent aminotransferase;COG0075;Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG;PucG;HELO_RS11840;EF;;thiC;;HELO_3149;pyridoxal phosphate-dependent aminotransferase;1.173132429577083;-0.061471067796869505;-0.09029164502748976;-0.21125174546149772;-1.3843841750385808
HELO_3150;273.78949180897666;390.45513724307165;156.47816201008615;329.61825427061905;252.80339331446103;159.6700856591792;15.608828599694448;12.150240718364278;20.374200634889032;29.253922409565455;30.751355629789515;14.962533613080101;HELO_3150;YohC family protein;;;;;;;;;HELO_3150;YohC family protein;-0.510520141486067;-0.02894956656697012;0.6596100119204724;0.7742254892775611;1.284745630763628
HELO_3151;556.1091583876765;618.0017708319764;505.6248327352693;547.0066265434823;825.9541345006986;516.4860771146663;32.900357587197;35.734579873927046;25.925063092394208;72.97406408378585;32.75602540467697;9.04870576802599;cyoE1;protoheme IX farnesyltransferase;COG0109;Polyprenyltransferase (heme O synthase);CyoE;HELO_RS11850;HI;cyoE1; protoheme IX farnesyltransferase;2.5.1.141;cyoE1;protoheme IX farnesyltransferase;-0.15198350385303883;-0.030602253681113467;0.6762872675321212;0.10643998519475595;0.2584234890477948
HELO_3152;1121.445613854374;1297.211545359398;241.66926751189058;216.2361459120632;413.7099775609343;273.7606547162164;67.64867087009462;53.917010641099026;54.50069942259436;53.77179062233335;192.2481653436829;87.53190484100824;cyoD;cytochrome bo(3) ubiquinol oxidase subunit 4;COG3125;Heme/copper-type cytochrome/quinol oxidase, subunit 4;CyoD;HELO_RS11855;C;cyoD; cytochrome bo(3) ubiquinol oxidase subunit 4;;cyoD;cytochrome bo(3) ubiquinol oxidase subunit 4;-0.20987994825066103;-0.17918401524539185;0.5939273303106116;2.030398210936667;2.240278159187328
HELO_3153;725.3507681656738;799.3830560425082;658.7876140688369;733.5684678737489;1213.9409987173563;716.0795476321877;54.30518019795812;27.29167826171457;23.127358346834296;116.64045845491674;112.59085056292959;27.259809648376827;cyoC;cytochrome bo(3) ubiquinol oxidase subunit 3;COG1845;Heme/copper-type cytochrome/quinol oxidase, subunit 3;CyoC;HELO_RS11860;C;cyoC; cytochrome bo(3) ubiquinol oxidase subunit 3;;cyoC;cytochrome bo(3) ubiquinol oxidase subunit 3;-0.14002420547536332;-0.1201314749700888;0.7606811787126766;0.01853325052577226;0.15855745600113558
HELO_3154;804.4876381899304;896.365921994733;993.5622585052023;1358.2428122673125;1804.6906278796116;1031.812307682471;63.63692053975368;53.216291650122685;74.1445069709816;196.51510927216816;91.3832561572186;38.33201211529916;cyoB;cytochrome bo(3) ubiquinol oxidase subunit 1;COG0843;Heme/copper-type cytochrome/quinol oxidase, subunit 1;CyoB;HELO_RS11865;C;cyoB; cytochrome bo(3) ubiquinol oxidase subunit 1;7.1.1.3;cyoB;cytochrome bo(3) ubiquinol oxidase subunit 1;-0.15583394977466547;-0.05444450785580912;0.8059726365574509;-0.35864374479034034;-0.20280979501567487
HELO_3155;905.042853393647;940.4607618790677;1024.649177287606;1569.8954788359986;1698.1675204078372;1025.0738427469394;52.35089121839793;23.154859028022116;27.907796672065032;115.9889481246728;95.70801717468485;10.710384324472345;cyoA;cytochrome bo(3) ubiquinol oxidase subunit 2;COG1622;Heme/copper-type cytochrome/quinol oxidase, subunit 2;CyoA;HELO_RS11870;C;cyoA; cytochrome bo(3) ubiquinol oxidase subunit 2;7.1.1.3;cyoA;cytochrome bo(3) ubiquinol oxidase subunit 2;-0.05532168008614313;-0.0005972178066766531;0.7276935342804904;-0.17948336751908656;-0.12416168743294342
HELO_3156;49.07774178632612;19.745571962748993;41.50180712064269;59.04582978204609;55.267625440872685;42.640717825952315;2.196513862203001;1.0695481599479275;3.891878976964908;3.8077311090648047;5.065779008728981;5.503051104116027;deoR;DeoR family transcription regulator DeoR;COG1349;DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family;GlpR;HELO_RS11875;KG;deoR; DeoR family transcription regulator DeoR;;deoR;DeoR family transcription regulator DeoR;1.27136607324719;-0.038150648039073864;0.36663024919510523;0.19849467453796787;-1.0728713987092222
HELO_3157;40.614769912917204;71.43303920397678;158.118035151006;231.2531927685112;221.74381055278138;161.78775524387683;3.1251989323895626;3.64575313436403;3.047547852942473;4.607081803125551;6.971640088859815;17.187552844780438;HELO_3157;YfeN family protein;;;;;;;;;HELO_3157;YfeN family protein;-0.7995522497989818;-0.03289481893816237;0.4523931583217111;-1.967824619745687;-1.1682723699467052
HELO_3158;49.22973099201471;65.67281804733221;115.00668774191696;146.58604289278585;166.1841527810319;124.59956383077899;1.6369294136195973;1.5781533197393542;2.1372107433885934;1.9859339192881091;7.625127362345035;11.211682414264999;nupC;CNT family transport protein (probable substrate purine nucleoside);COG1972;Nucleoside permease NupC;NupC;HELO_RS11885;F;nupC; CNT family transport protein (probable substrate purine nucleoside);;nupC;CNT family transport protein (probable substrate purine nucleoside);-0.4085571579201144;-0.1146234756187674;0.4126066480811694;-1.322218000482235;-0.9136608425621207
HELO_3159;61.42929738898653;86.72483865164084;150.0241488198196;152.2456741458927;184.5299707702171;153.33752599485885;3.6471076492176686;6.676579155796345;13.398240481179899;15.848532681341542;11.647370157936306;6.593527399456757;deoC;deoxyribose-phosphate aldolase;COG0274;Deoxyribose-phosphate aldolase;DeoC;HELO_RS11890;F;deoC; deoxyribose-phosphate aldolase;4.1.2.4;deoC;deoxyribose-phosphate aldolase;-0.4907621600824301;-0.03130962938892434;0.26556337576110156;-1.305793750704055;-0.8150315906216248
HELO_3160;59.12461246929134;90.98204984756443;163.31969879901132;159.518095962415;212.66260677708178;175.43536036276552;2.7607090561538605;9.657551148498182;7.349792290625902;2.31669952706035;12.61352012715634;14.097870035869555;deoA;thymidine phosphorylase;COG0213;Thymidine phosphorylase;DeoA;HELO_RS11895;F;deoA; thymidine phosphorylase;2.4.2.4;deoA;thymidine phosphorylase;-0.613396658886427;-0.1026342858873539;0.27619471497914017;-1.5531121329784119;-0.9397154740919849
HELO_3161;51.369302311139904;84.18468440835788;153.9813909396092;132.43970584501682;186.6361674530809;177.22275291156765;2.6963724880293984;6.532919322972043;1.5987343484281225;6.838492936523976;6.2600558156598565;8.703259392322202;deoB;phosphopentomutase;COG1015;Phosphopentomutase;DeoB;HELO_RS11900;G;deoB; phosphopentomutase;5.4.2.7;deoB;phosphopentomutase;-0.7018726829641686;-0.2015865337557461;0.07425640747950357;-1.7668882413650246;-1.065015558400856
HELO_3162;76.76444814219826;70.86285016785503;103.86102482412014;86.21104828990663;145.74426168007486;110.05855055014854;6.271781968747715;3.1418601476640524;4.298043830954853;4.332524518209827;2.3632155088034055;5.0691185737656745;deoD;purine nucleoside phosphorylase DeoD;COG0813;Purine-nucleoside phosphorylase;DeoD;HELO_RS11905;F;deoD; purine nucleoside phosphorylase DeoD;2.4.2.1;deoD;purine nucleoside phosphorylase DeoD;0.11386458824167445;-0.08284192149840752;0.40198361674254546;-0.5141378233658251;-0.6280024116074996
HELO_3163;98.69201424117064;94.33860721334064;86.18794516947253;64.69327653398784;107.40149777403627;94.56252264296724;1.2536676905430018;7.227930362835682;10.623297357675847;5.347823769377886;8.254811640055953;1.2424324627505825;cdd;cytidine deaminase;COG0295;Cytidine deaminase;Cdd;HELO_RS11910;F;cdd; cytidine deaminase;3.5.4.5;cdd;cytidine deaminase;0.06441739372075972;-0.13231626026402576;0.18186784699692726;0.06103300486680663;-0.003384388853953091
HELO_3164;127.38241393366387;107.25453217127618;96.61504826403227;79.22123456273066;111.99891103047314;106.21446280432247;13.643173041624413;8.124604565658942;15.784293595368483;5.116679918366137;13.008442390443669;6.565934857156998;HELO_3164;YtfP family prptein;COG2105;Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family;YtfP;HELO_RS11915;E;;cdd;;HELO_3164;YtfP family prptein;0.24602016697972662;-0.13532405789065827;0.0758093367255217;0.25994806015154825;0.013927893171821637
HELO_3165;102.39668878116657;94.72650513048605;74.47655874819475;52.42669096596551;91.35514514034969;78.851980659569;11.543471446877408;0.9937854428178474;2.7005280897212973;5.254787680920643;1.8440616003585082;2.4427385852627075;HELO_3165;alpha/beta hydrolase fold protein;COG0412;Dienelactone hydrolase;DLH;HELO_RS11920;Q;;;3.1.1.45;HELO_3165;alpha/beta hydrolase fold protein;0.11119964072102562;-0.0812995461825512;0.20986414364982586;0.3727898869226296;0.261590246201604
HELO_3166;179.9402962683702;123.66038762116204;139.69084314061578;159.43190330113455;132.7203258249052;112.44130124157124;3.811092548165523;6.749371783200245;18.095561450877078;29.16126221594688;17.090353844173922;9.643482995062866;HELO_3166;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS11925;J;;;2.3.1.-;HELO_3166;GNAT family acetyltransferase;0.5375106350098324;0.31058244748034536;0.2372727889787445;0.6735677524337484;0.13605711742391602
HELO_3167;55.99597225555997;32.09400682185512;23.620352705064153;28.953061983355127;26.00380899327243;24.013784223311063;1.9311189830848006;2.509396062660064;5.233868572476518;3.375518937068221;2.5072312102697722;2.8302722686146313;HELO_3167;glutaredoxin domain protein;COG0625;Glutathione S-transferase;GstA;HELO_RS11930;O;;;;HELO_3167;glutaredoxin domain protein;0.7842899966933476;-0.022871903235660795;0.11043958653164143;1.1881366387969239;0.40384664210357624
HELO_3168;56.46473352850732;34.9891881887472;41.82458546066172;44.85152118967495;45.97944143500982;42.872790736842795;3.5947399578686996;2.9019844528042436;0.4894336545222179;4.262042788045154;1.6292489067201987;5.202769382456403;HELO_3168;LacI family transcription regulator;COG1609;DNA-binding transcriptional regulator, LacI/PurR family;PurR;HELO_RS11935;K;;;;HELO_3168;LacI family transcription regulator;0.6751132769007073;-0.03488719755534131;0.09870308170623154;0.3893503577992261;-0.2857629191014812
HELO_3169;34.28403569631317;16.081014052506344;49.28258947772367;43.25138669336287;67.4245821994331;51.02745014454971;2.910373655005038;1.232662241971746;5.373225325592101;2.3003911558685384;3.04870993309751;2.2231966565220302;thuB;3-ketotrehalose formation protein ThuB;COG0673;Predicted dehydrogenase;MviM;HELO_RS11940;R;thuB; 3-ketotrehalose formation protein ThuB;;thuB;3-ketotrehalose formation protein ThuB;1.0466219557321477;-0.04921405454115657;0.39524171768252536;-0.5602574207945272;-1.606879376526675
HELO_3170;30.349326732695307;14.060206145729714;61.96172133436081;54.99755899888529;92.9802228384677;69.91507312698;1.3526987094516902;1.5378211646118718;2.341379301687614;4.057282130679421;8.861748596914724;3.2428795470837892;thuA;3-ketotrehalose formation protein ThuA;COG4813;Trehalose utilization protein;ThuA;HELO_RS11945;G;thuA; 3-ketotrehalose formation protein ThuA;;thuA;3-ketotrehalose formation protein ThuA;1.0576929417089316;-0.17161732372636607;0.4062648810499878;-1.1776578478778141;-2.2353507895867457
HELO_3171;65.29496962549956;45.3034345156049;56.52627792149372;56.20813110777751;50.757855497331434;57.981265002503335;2.321329005727188;0.5545562881246006;4.978449037397401;2.2726309245870415;1.0133036686292123;2.417456140385776;mscS3;mechanosensitive ion channel MscS;COG0668;Small-conductance mechanosensitive channel;MscS;HELO_RS11950;M;mscS3; mechanosensitive ion channel MscS;;mscS3;mechanosensitive ion channel MscS;0.5177801966403708;-0.03603563732346515;-0.18847892213473827;0.16864263972379678;-0.349137556916574
HELO_3172;58.89016351569594;38.606251605573554;51.414607313808496;45.990760769146874;43.027794145009544;49.87170574298242;3.306295297816918;3.3393541539689515;3.9166378365401773;3.9611112109710978;1.9832056726924627;3.469054269928244;HELO_3172;amidoligase domain protein;;;;;;;;;HELO_3172;amidoligase domain protein;0.5965909023500551;0.04310546037292706;-0.20844890397706983;0.23545560226086604;-0.36113530008918904
HELO_3173;31.556516868573226;17.058094488739638;16.190254987692807;15.36913272477666;16.959887787406313;14.042641240918805;2.756175775457838;1.0669836411717466;3.0873403723457242;0.5508416642535209;1.4464588211279215;1.445252364852366;HELO_3173;peptidase C26 family protein;COG2071;Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (putrescine degradation), contains GATase1-like domain;PuuD;HELO_RS11960;E;;;;HELO_3173;peptidase C26 family protein;0.850300691938588;0.19253304203133137;0.25572043338331607;1.11388845509161;0.2635877631530219
HELO_3174;233.44734552509337;145.7638270215334;383.20924748813576;484.00700434072365;1047.9848718381493;376.7522636534923;12.414220002326848;4.621957832326597;43.890636321257624;25.805525424104154;22.3769121946886;35.902685334698276;osmC;peroxiredoxin OsmC;COG1764;Organic hydroperoxide reductase OsmC/OhrA;OsmC;HELO_RS11965;V;osmC; peroxiredoxin OsmC;1.11.1.28;osmC;peroxiredoxin OsmC;0.6757675145921365;0.02445184281901902;1.4734815661513743;-0.688176456087068;-1.3639439706792045
HELO_3175;17.6398350036346;22.528056742816194;26.92184599799224;27.556857184343624;89.08061077795281;25.294195924647482;2.377189478094068;1.0590430326307636;2.362018605270352;1.3218628875720635;4.479381412464418;2.8272991803604497;HELO_3175;aldo/keto reductase domain protein;COG0656;Aldo/keto reductase, related to diketogulonate reductase;ARA1;HELO_RS11970;Q;;osmC;;HELO_3175;aldo/keto reductase domain protein;-0.33599307912226095;0.08664994570655882;1.7764722294843773;-0.49635529036283277;-0.16036221124057182
HELO_3176;11.586297373467042;7.70146039969567;9.066408744105894;8.950488781218647;6.9968904961099225;7.484168658809852;2.303714178113364;0.7183883582866073;0.6782205392767102;2.079838991976735;0.44381772559015265;1.4606186474321041;paiB;PaiB family protein;COG2808;Predicted FMN-binding regulatory protein PaiB;PaiB;HELO_RS11975;T;paiB; PaiB family protein;;paiB;PaiB family protein;0.5325244751649434;0.2467038784773754;-0.0853341680704025;0.5690087286947492;0.03648425352980578
HELO_3177;13.53784569940558;9.550730106292223;7.33931229275008;6.291669401844648;5.981552692359522;7.9620020954882555;1.9136082495700686;0.5576296917151501;1.5782540131188623;0.46899824617003183;0.1414953762860464;1.6643491050281884;HELO_3177;GNAT family acetyltransferase;COG1670;Protein N-acetyltransferase, RimJ/RimL family;RimL;HELO_RS11980;JO;;paiB;;HELO_3177;GNAT family acetyltransferase;0.4624706620408827;-0.10389264810563059;-0.3602731373488717;0.6979205294130941;0.2354498673722114
HELO_3178;7.97336780784802;5.943343709326219;9.456810287874534;8.767146899524464;5.766729980657646;7.868002691421506;1.4378364460904163;0.924088252475222;1.4723282180425006;1.7373270485871037;1.1664915704286498;1.2980395006488525;HELO_3178;GNAT family acetyltransferase;COG3393;Predicted acetyltransferase, GNAT family;;HELO_RS11985;R;;;;HELO_3178;GNAT family acetyltransferase;0.37001895729145273;0.23776173041463444;-0.3901503876137862;0.01704033871180366;-0.3529786185796491
HELO_3179;18.66878524011831;12.20023084998599;17.439146554896272;15.94839431903427;18.097764733572017;15.79115627001507;0.8934535941941216;0.2508415331620788;0.17317318315944302;1.596483946108323;1.700861569425553;0.7848040172804268;HELO_3179;YjiR family protein;COG1167;DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain;ARO8;HELO_RS11990;KE;;;;HELO_3179;YjiR family protein;0.5753446982396091;0.13507030267787457;0.1857022099372525;0.22820627803089533;-0.34713842020871377
HELO_3180;120.08876765879698;42.982271806262986;65.30333172907622;72.69889331462753;60.70938743601652;59.418584778554155;6.991909003957487;4.116010379449328;4.437043120718947;7.308297433398858;4.561764819724122;5.079491731108107;HELO_3180;DUF1415 family protein;COG3310;Uncharacterized conserved protein, DUF1415 family;;HELO_RS11995;S;;;;HELO_3180;DUF1415 family protein;1.4610710146656887;0.13408897596108016;0.030497582274604085;1.0030007486476373;-0.45807026601805134
HELO_3181;5.663760270227539;3.4866215188656735;4.741950155564587;8.370075902156268;6.080747065802625;4.80617241409626;0.21904409779750492;0.2265153157667887;0.3736156073853756;0.7430921233989013;0.5914636487282444;0.21857031887806;HELO_3181;HTH domain protein;COG2909;ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT;MalT;HELO_RS12000;K;;;;HELO_3181;HTH domain protein;0.5707070137753449;-0.01604660645773137;0.2863141688572255;0.19874908708532057;-0.37195792669002437
HELO_3182;3.3927413268733133;0.9112786413627081;2.0536663824311745;3.1128811154818767;3.014149172150948;2.5658049073220384;0.3457277248591565;0.16435651417074837;0.4580295214971699;0.4824338185038406;0.191407641528478;0.5392647533647735;HELO_3182;DUF1326 domain protein;COG5588;Uncharacterized conserved protein, DUF1326 domain;;HELO_RS12005;S;;;;HELO_3182;DUF1326 domain protein;1.200583425505478;-0.22368531806842817;0.1708664582875712;0.300893774436612;-0.8996896510688659
HELO_3183;4.048267883056589;1.9276567818548178;1.642061394920498;2.0759917370102503;2.3416768248832898;1.6733276428317367;0.5181752572625438;0.20813611271462687;0.28739765157654545;0.6396462929802113;0.5690592006815386;0.41078748852126795;HELO_3183;DUF2182 domain protein;COG5486;Predicted metal-binding membrane protein;;HELO_RS12010;S;;;;HELO_3183;DUF2182 domain protein;0.7860420360374443;-0.01697267340066211;0.32193555142714336;0.9171518030158812;0.1311097669784369
HELO_3184;40.850333888953884;17.90115469491659;42.63281372456188;45.683968525489746;42.131512750302356;39.75319982975644;1.1204757829188456;1.4387378312107038;10.06540987515872;6.32624040651555;5.991836815847562;0.46983884394110836;nfi;deoxyribonuclease V;COG1515;Deoxyinosine 3'-endonuclease (endonuclease V);Nfi;HELO_RS12020;L;nfi; deoxyribonuclease V;3.1.21.7;nfi;deoxyribonuclease V;1.1467647597205897;0.09850017071412509;0.08182897630266428;0.03832579262488167;-1.108438967095708
HELO_3185;61.32123523676156;42.81461263802678;68.14006608961016;77.95968903509299;70.45684183270332;75.10041371850603;3.4961668242297548;1.9893682277822589;1.886467941025995;2.6230791200793453;3.0799313142521734;3.485029337439095;sbcD;nuclease SbcCD subunit D;COG0420;DNA repair exonuclease SbcCD nuclease subunit;SbcD;HELO_RS12025;L;sbcD; nuclease SbcCD subunit D;;sbcD;nuclease SbcCD subunit D;0.5083117244132431;-0.13838231429093373;-0.09083214417897345;-0.28818046834495803;-0.7964921927582012
HELO_3186;36.261041015505555;26.582633635186156;57.809966321575246;64.98683478561871;60.06766670025303;58.37788843519933;2.735713813658967;0.6591365677211506;1.7561585517396876;3.481760663515681;3.6724653656134705;6.0294952029122015;sbcC;nuclease SbcCD subunit C;COG1196;Chromosome segregation ATPase Smc;Smc;HELO_RS12030;D;sbcC; nuclease SbcCD subunit C;;sbcC;nuclease SbcCD subunit C;0.4339077671751914;-0.013865125566412395;0.040482933234723184;-0.6722578083880251;-1.1061655755632165
HELO_3187;46.616223291875656;39.75777423106726;56.08817279946194;55.7037886632013;75.01582375603012;55.19272381833047;3.2879711053456213;0.593692779363068;3.9818236937664597;4.950431962662301;9.432074336304586;1.1381333089704322;ybbO;probable oxidoreductase YbbO (short-chain dehydrogenase family);COG0300;Short-chain dehydrogenase;YqjQ;HELO_RS12035;R;ybbO; probable oxidoreductase YbbO (short-chain dehydrogenase family);;ybbO;probable oxidoreductase YbbO (short-chain dehydrogenase family);0.2243779284164047;0.022808553795984565;0.4359164334957848;-0.2389301364972729;-0.4633080649136776
HELO_3188;28.366550217604082;12.598918614300482;32.61476844477618;35.305115499162035;26.854100076425272;30.51549745608679;2.2114512057130464;0.6859474699785768;3.8656079872966322;2.7673732511733475;5.727508302481893;2.1969450201033123;HELO_3188;uncharacterized protein;;;;;;;;;HELO_3188;uncharacterized protein;1.1106818646649628;0.0930337764847966;-0.17817172965206396;-0.10188763749394614;-1.212569502158909
HELO_3189;69.77902244219918;16.00190284674757;18.652213070539272;33.60642929829805;15.03330853648482;19.44778527466279;10.054907525163777;0.4986382479488267;1.3619126013170453;2.162529577634213;1.1560337235430007;2.495652677602278;nemA;N-ethylmaleimide reductase;COG1902;2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family;FadH;HELO_RS12050;C;nemA; N-ethylmaleimide reductase;1.-.-.-;nemA;N-ethylmaleimide reductase;2.0576256149535794;-0.057252805437232546;-0.3508724294869259;1.7913772447394543;-0.2662483702141252
HELO_3190;137.7001223667974;66.09985918551548;108.72236782160418;130.11873460856145;112.8510762881735;99.3953299844568;2.1019067719910605;3.869127353349359;10.980403311965297;7.34566280582815;7.5018111616680585;1.2040070844520787;argE;acetylornithine deacetylase;COG0624;Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase;ArgE;HELO_RS12055;E;argE; acetylornithine deacetylase;3.5.1.16;argE;acetylornithine deacetylase;1.047587416536384;0.12816549909550545;0.18145576795091056;0.46627689839741837;-0.5813105181389657
HELO_3191;72.45498422120029;62.897570725951795;89.24982263619567;127.50636943084612;95.75140395653413;90.14661464063074;2.1637563605458885;1.7549790567437906;7.535957036182443;14.174179449571426;8.454510754513333;5.057034239722171;HELO_3191;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS12060;GER;;argE;;HELO_3191;DMT superfamily transport protein;0.20109930339489246;-0.014264976069227053;0.08609352350067301;-0.31132868594611907;-0.5124279893410115
HELO_3192;1084.498600315701;750.2691814108522;941.0393118784244;1402.6877618869132;1291.9852739787164;950.8869797780238;34.81173688685467;15.255605003040403;102.13472892307703;111.1504858703994;186.95846799367186;76.20092124593953;rhlD;ATP-dependent RNA helicase RhlD;COG0513;Superfamily II DNA and RNA helicase;SrmB;HELO_RS12065;L;rhlD; ATP-dependent RNA helicase RhlD;3.6.4.13;rhlD;ATP-dependent RNA helicase RhlD;0.5309560393786885;-0.015003022812800637;0.44184365058250386;0.1894956721180474;-0.3414603672606411
HELO_3193;94.37060648368553;59.185309614800616;150.35404475983634;176.55486055970698;165.37372825420712;143.66290341010176;4.404863276755195;3.632225453563657;13.878067500393747;2.6267474657809786;18.00374445524245;20.421484593040734;HELO_3193;UPF0178 family protein;COG1671;Uncharacterized conserved protein YaiI, UPF0178 family;YaiI;HELO_RS12070;S;;rhlD;;HELO_3193;UPF0178 family protein;0.6641333032135268;0.06523221780843791;0.2017326261384902;-0.6010784154404787;-1.2652117186540055
HELO_3194;34.28390869963866;24.616327116036754;31.07247045403962;44.65042043421332;45.39998538246815;32.372374999468555;1.3977311997959223;0.6910021094070593;1.4965601657099514;2.7883995709428455;5.29875430734301;2.3301569355072247;yqjG;glutathionyl-hydroquinone reductase YqjG;COG0435;Glutathionyl-hydroquinone reductase;ECM4;HELO_RS12075;C;yqjG; glutathionyl-hydroquinone reductase YqjG;1.8.5.7;yqjG;glutathionyl-hydroquinone reductase YqjG;0.46194675333945057;-0.0573188770341293;0.47546998893801984;0.0803560274701578;-0.38159072586929277
HELO_3195;74.77632075614623;51.439767000339344;85.95490952706946;119.2272104773153;100.02211362546926;86.97559792450959;4.7254522069427995;2.8266300153809776;7.62562656798648;3.751444640298736;10.337173424915774;5.40755974891301;HELO_3195;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS12080;K;;yqjG;;HELO_3195;LysR family transcription regulator;0.5310858175140742;-0.016835928987407378;0.19949581247512693;-0.2153563213332168;-0.746442138847291
HELO_3196;10.345880554954741;6.2740169228878315;9.235845688235704;9.956855106919685;13.293509579299728;9.68117781469431;0.8223031718807686;0.8575882263781772;0.40222793544648866;0.7666104274087026;0.20661938736293517;1.1213232330081637;HELO_3196;pirin domain protein;COG1741;Redox-sensitive bicupin YhaK, pirin superfamily;YhaK;HELO_RS12085;R;;;1.13.11.24;HELO_3196;pirin domain protein;0.6413443937478673;-0.06144043881835026;0.4202894523760854;0.08709783912180091;-0.5542465546260664
HELO_3197;479.4176681833291;216.73592503988016;390.7484627413023;517.0590543205676;445.1369611485596;367.0455081085285;2.2781515524310105;12.63074281288661;16.601243785958413;14.28821234234996;46.74716812358708;28.80194123628036;HELO_3197;peptidase M23 family protein;COG3061;Cell division protein YtfB/OapA (opacity-associated protein A);OapA;HELO_RS12090;D;;;3.4.24.-;HELO_3197;peptidase M23 family protein;1.141709746950455;0.09004344969773292;0.2776025124104482;0.3844050458656163;-0.7573047010848386
HELO_3198;17.017279548315884;7.10156023793179;9.55001121164536;18.317775692748693;17.268952358781323;9.405479704728029;0.4099079678502825;0.11158585679811668;1.0290726253013514;1.5830501371569585;1.3785279349394068;0.871281376612133;HELO_3198;RNA polymerase sigma-70 factor domain protein;COG4941;Predicted RNA polymerase sigma factor, contains C-terminal TPR domain;;HELO_RS12095;K;;;;HELO_3198;RNA polymerase sigma-70 factor domain protein;1.1531095121524397;0.019901055578295246;0.812050427819782;0.7920377167305541;-0.3610717954218856
HELO_3199;29.02999878419506;16.889277972354773;28.23972890115471;44.658013020476496;38.56424568733306;27.29680854135209;0.6382229820452727;1.4587658602534286;3.7478162043834113;1.0694433366062712;2.9589234784310308;3.2889771131704153;yjdN;PhnB protein;COG2764;Zn-dependent glyoxalase, PhnB family;PhnB;HELO_RS12105;C;yjdN; PhnB protein;;yjdN;PhnB protein;0.7473092564140789;0.04729058755783644;0.4835579040499658;0.08576506877132051;-0.6615441876427584
HELO_3200;52.71662454347949;20.42651443341658;25.174745602889445;31.5480206602777;29.516894018472513;21.54914533718097;0.9550207578405611;1.6031624623976097;4.95768734947342;4.695729915645836;0.7322291034175286;3.5848954070860355;HELO_3200;YciI family protein;COG3795;5-chloro-2-hydroxyhydroquinone dehydrochlorinase TtfG, YCII superfamily;YCII;HELO_RS12110;Q;;yjdN;;HELO_3200;YciI family protein;1.3259714731162333;0.2151027622465005;0.43653538030187455;1.252295898077615;-0.07367557503861821
HELO_3201;21.728169574770153;9.825825350644347;22.133328105411262;32.30845982397821;23.897072976936784;21.603555733585367;2.2890201704657493;0.8441148382737172;2.8112042211745956;1.7264424880145617;2.3645455323682993;0.8770251407932441;HELO_3201;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS12115;K;;;;HELO_3201;LysR family transcription regulator;1.0700044817765275;0.03342309722432635;0.1394264030746628;0.007931761799293113;-1.0620727199772344
HELO_3202;1.04194095528527;0.5551457639531155;0.5324202921844388;0.9688107191315908;0.9119664438524285;1.124061145470339;0.37469270475964794;0.12315621779769795;0.3533886936107219;0.25626080562291653;0.2319129107028975;0.4637272639280904;HELO_3202;DUF1127 domain protein;;;;;;;;;HELO_3202;DUF1127 domain protein;0.392891339254101;-0.4710132626340563;-0.15176809429962068;-0.056884147800636775;-0.4497754870547378
HELO_3203;62.99416171944811;42.65007745673689;88.82976372765567;93.56283936978998;108.8067075490499;94.03289012174098;4.279070127372139;2.2384877400627046;0.5201075268279032;2.2086152523615157;0.6265802762077325;2.2804756154267785;cytR;LacI family transcription regulator CytR;COG1609;DNA-binding transcriptional regulator, LacI/PurR family;PurR;HELO_RS12125;K;cytR; LacI family transcription regulator CytR;;cytR;LacI family transcription regulator CytR;0.551956078038395;-0.08123336579711093;0.20846737397266146;-0.5704866131121742;-1.1224426911505692
HELO_3204;3.4378755050526983;1.3765097171880647;4.916489546080009;5.029640744963081;3.9134490904190073;5.616478885367783;0.9094004638450068;0.5018220156913183;1.3696055203829476;0.32599690424652805;0.5422727183346479;1.0627679224329416;HELO_3204;GFO family oxidoreductase;COG0673;Predicted dehydrogenase;MviM;HELO_RS12130;R;;cytR;;HELO_3204;GFO family oxidoreductase;0.9010248958166145;-0.1613222274026116;-0.4293275494166644;-0.5761944607727068;-1.4772193565893212
HELO_3205;3.4421290263920956;1.813345507594759;5.9337331774672615;4.679042592476918;3.6766265336442103;4.798824729833645;0.19006712136603232;0.4186311851887201;0.4266774678944448;0.3478901167197689;0.5635792884591658;1.6514000799291946;HELO_3205;iolE family protein;COG1082;Sugar phosphate isomerase/epimerase;YcjR;HELO_RS12135;G;;;;HELO_3205;iolE family protein;0.6589645568794213;0.25787178680675416;-0.3102923107808775;-0.3845092351851789;-1.0434737920646002
HELO_3206;2.6953350863940475;1.1941655479064914;4.268533722929319;4.449196314725859;4.687166479662614;4.649127346367254;0.2699214833866705;0.08003945697050176;0.44454356165529935;0.6210390136841699;0.19786311094337808;1.2149762145292742;yegT;major facilitator superfamily transport protein YegT;;;;;;;;;yegT;major facilitator superfamily transport protein YegT;0.7520328113663308;-0.10062651961739943;0.009682013500712294;-0.6123228319102831;-1.364355643276614
HELO_3207;43.72412420246109;11.526679585823274;23.78295401428704;38.16658741665744;23.816419841561302;20.34603646204243;2.48806724492486;0.4431069954768127;1.9660511687412274;3.3049578312828367;1.4678728263836185;2.254998081207552;HELO_3207;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS12145;G;;yegT;;HELO_3207;major facilitator superfamily transport protein;1.8360491774512333;0.21537994565202467;0.21732678435667463;1.0670850166870878;-0.7689641607641455
HELO_3208;28.508922986475046;7.395719833175114;21.46550164321324;22.758878198045863;22.0637852670645;22.607863222291485;2.0604276751731736;0.1722625155711454;2.4822773046566295;0.9094329175041942;0.8015548746420199;3.1533402932467327;HELO_3208;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS12150;K;;;;HELO_3208;LysR family transcription regulator;1.8134253368728008;-0.07155619044697747;-0.03363815736544584;0.3218837990873089;-1.491541537785492
HELO_3209;140.76124369107524;42.34219325915836;111.78660406851094;187.18899976303746;109.31605228352886;102.90028553765198;7.2248750920315965;2.4596469712636733;3.687192407589853;12.209679445623838;17.8863452502547;12.330817808674828;HELO_3209;YcbB family protein;COG2989;Murein L,D-transpeptidase YcbB/YkuD;YcbB;HELO_RS12155;M;;;;HELO_3209;YcbB family protein;1.7096191004653223;0.11839610656601529;0.08644311626017398;0.4482635469783762;-1.261355553486946
HELO_3210;110.73090528815214;40.70292184763671;61.44604024988583;64.07940313180163;80.5746740628474;59.82735280022465;2.7837020580553995;3.459783855825426;3.952948857727452;2.5257518569307353;8.718116720968482;4.518645177835451;HELO_3210;YkuD domain protein;;;;;;;;;HELO_3210;YkuD domain protein;1.421807924767438;0.03788987271719879;0.4234010982977052;0.8772361724237046;-0.5445717523437335
HELO_3211;1.2059208350371111;0.8325239030844657;0.6152057813753403;0.7595661203164776;1.2931401853440656;0.8287068655571552;0.08655183428506895;0.14572702736395515;0.21014528430448326;0.1587788357385002;0.09608021321619967;0.22231334394533506;HELO_3211;major facilitator superfamily transport protein (probable substrate nitrate);COG2223;Nitrate/nitrite transporter NarK;NarK;HELO_RS12165;P;;;;HELO_3211;major facilitator superfamily transport protein (probable substrate nitrate);0.26754900043919194;-0.17910585564657755;0.32650071780072243;0.2705571818157213;0.003008181376529362
HELO_3212;196.2051602469794;213.32334784841245;509.33801396568634;358.3460611694358;546.9715904296958;546.2736574241457;11.441575578846104;15.75993008044714;39.91151158075972;10.905892490507856;11.698171624662812;26.746311482053475;HELO_3212;peroxiredoxin;COG0678;Peroxiredoxin;AHP1;HELO_RS12170;O;;;1.11.1.25,1.11.1.27;HELO_3212;peroxiredoxin;-0.1200917190966111;-0.10080930632280172;0.001838683389397744;-1.4725651121938066;-1.3524733930971955
HELO_3213;341.294695088372;337.9103914551202;300.29276126274;232.75289941213282;353.2788004348092;333.7532238241576;27.477352162824417;30.25515177609777;12.341033941162536;27.809555038076056;2.1532463661278505;17.177160417309505;HELO_3213;homolog to glutathione-dependent formaldehyde-activating enzyme;COG3791;Uncharacterized conserved protein;;HELO_RS12175;S;;;;HELO_3213;homolog to glutathione-dependent formaldehyde-activating enzyme;0.014335061014477901;-0.15193193767397162;0.08178718969638865;0.03214098409455346;0.01780592308007556
HELO_3214;41.280580310436875;59.251468395065054;28.41696312698684;33.81940667073297;36.74603656697263;30.271143560150264;4.984896661949392;5.025716610110339;2.79980816096337;7.607901194661404;5.420001896129909;6.197387206909442;HELO_3214;glyoxalase domain protein;;;;;;;;;HELO_3214;glyoxalase domain protein;-0.5110012236790933;-0.0881836613771183;0.2714931872144293;0.4351631997635055;0.9461644234425988
HELO_3215;71.7420047649598;59.961006713856676;68.24680936234445;82.73639410679048;46.993118926314914;46.44987273578238;4.027129551738323;3.6517129897581118;7.345250665223986;25.067344879816797;6.918124898170488;4.268681621375114;HELO_3215;GNAT family acetyltransferase;COG3153;Predicted N-acetyltransferase YhbS;yhbS;HELO_RS12185;R;;;;HELO_3215;GNAT family acetyltransferase;0.2549019591401187;0.5453433807928691;0.016423354615811014;0.6163844690914937;0.361482509951375
HELO_3216;11.094750101054528;3.2440590815732206;7.914575003744164;6.448795939153555;7.767002489358025;7.0814629864835625;0.43316794555649013;0.22558403614505787;0.3509105184127889;0.12650143720124393;1.5238145442363158;1.6369392747586649;HELO_3216;DUF839 family protein;COG3211;Secreted phosphatase, PhoX family;PhoX;HELO_RS12190;R;;;;HELO_3216;DUF839 family protein;1.5108643157207213;0.14154953242483703;0.11746717004645646;0.5816925683127301;-0.9291717474079912
HELO_3217;2.393358866946653;3.4099757747320703;3.693024357679414;2.974223812417607;2.1757800944677808;4.101635102109922;0.3582504910208239;0.42657729506377;0.4560922990716295;0.5224422081817413;0.24935013482447624;0.8606737638255851;HELO_3217;phosphatase domain protein;COG0737;2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family;UshA;HELO_RS12195;VF;;;3.1.6.20;HELO_3217;phosphatase domain protein;-0.37805671936444574;-0.12044176465082224;-0.6838486957557943;-0.5882457015946785;-0.21018898223023275
HELO_3218;1.8219834755988;1.7494696023322813;0.9068231366483911;0.6962606696061117;0.5060058411918681;0.7732084500310535;0.6553756616473341;0.590084750637268;0.49139483509574516;0.35536482573069345;0.40512685226628314;0.4044375338911412;HELO_3218;uncharacterized protein;;;;;;;;;HELO_3218;uncharacterized protein;0.037556203621079254;0.10480889308776209;-0.23563477698233315;0.6703473974797834;0.6327911938587042
HELO_3219;2.0550445146658767;2.3341364295788334;2.389831913798668;2.4049305851610403;1.5374698927457846;2.2391236230298137;0.056948208187186496;0.04048651499452585;0.09869079323172406;0.4441024589305868;0.2545393484050293;0.04097317740092684;gspD2;general secretion pathway protein GspD;COG1450;Type II secretory pathway component GspD/PulD (secretin);PulD;HELO_RS12205;U;gspD2; general secretion pathway protein GspD;;gspD2;general secretion pathway protein GspD;-0.12611973766880347;0.06561020803573925;-0.3522128257521686;-0.08441012895248945;0.04170960871631402
HELO_3220;1.8492755085311707;1.8017373254349611;1.7429205043435154;2.02727598348843;1.3231654226885796;1.9467555292733125;0.13714859595311688;0.1761932148674871;0.2505282149274179;0.6466277544500424;0.43153452495333805;0.15542712366692288;gspE2;general secretion pathway protein GspE;COG2804;Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB;PulE;HELO_RS12210;NWU;gspE2; general secretion pathway protein GspE;7.4.2.8;gspE2;general secretion pathway protein GspE;0.024273425278970917;-0.10341456515557468;-0.3430354896269985;-0.048532246876247465;-0.07280567215521838
HELO_3221;1.491460182707088;1.2446960511607312;1.6192539453114356;1.3833190174195293;1.0010670096560395;1.4221965940867196;0.10446537387111234;0.44850272788970125;0.39349311610057053;0.6739413025647271;0.4602432298943949;0.4254334443565923;gspF2;general secretion pathway protein GspF;COG1459;Type II secretory pathway, component PulF;PulF;HELO_RS12215;NWU;gspF2; general secretion pathway protein GspF;;gspF2;general secretion pathway protein GspF;0.1504714114016199;0.11283997647069244;-0.27554648451543184;0.04067555371931397;-0.10979585768230593
HELO_3222;1.5194498283204316;2.381239043573967;1.874320932457058;1.855293889559893;1.3061616536230647;1.6173371421987481;0.23835811384634512;0.8649888323392341;0.6163228319579676;0.18811541312837177;0.3942788147718836;0.626748160873363;gspG2;general secretion pathway protein GspG;COG2165;Type II secretory pathway, pseudopilin PulG;PulG;HELO_RS12220;NWU;gspG2; general secretion pathway protein GspG;;gspG2;general secretion pathway protein GspG;-0.4244432869645409;0.1351213834221665;-0.18260612729975745;-0.054991044424820945;0.36945224253972
HELO_3223;2.491393055165657;1.9983817489471551;1.4980941420630216;0.8705919897975797;1.5369714713960871;1.4567403776788292;0.3088767064426462;0.8573404533541197;0.5207452772189481;0.3170652170584958;0.9054111028372956;0.04571857374274168;gspH2;general secretion pathway protein GspH;COG2165;Type II secretory pathway, pseudopilin PulG;PulG;HELO_RS12225;NWU;gspH2; general secretion pathway protein GspH;;gspH2;general secretion pathway protein GspH;0.21961870571967568;0.024082441465000937;0.04636189091478071;0.5070573769500384;0.2874386712303627
HELO_3224;1.119938689767743;1.408387577578444;0.4604621752932629;0.41471674060887914;0.4071104468355638;0.6946568493837392;0.5773701584980573;0.4225756039731489;0.4048201489674216;0.2641289007892659;0.5486090236931247;0.29671251197490633;gspI2;general secretion pathway protein GspI;COG2165;Type II secretory pathway, pseudopilin PulG;PulG;HELO_RS12230;NWU;gspI2; general secretion pathway protein GspI;;gspI2;general secretion pathway protein GspI;-0.1840450395986708;-0.21456817790033356;-0.2682575990394967;0.3230293695607811;0.5070744091594519
HELO_3225;1.587634818064999;1.9631601575436228;1.0643370223346176;0.6688170715884371;0.5339278540420264;0.9334593931957059;0.30980848789572357;0.133040144925439;0.2540900446047565;0.14652717101741186;0.3763112716082085;0.3788713599997967;gspJ2;general secretion pathway protein GspJ;COG4795;Type II secretory pathway, PulJ/GspJ component;PulJ;HELO_RS12235;U;gspJ2; general secretion pathway protein GspJ;;gspJ2;general secretion pathway protein GspJ;-0.19550257519961156;0.09449405841314007;-0.3339538355663457;0.42044956521789156;0.6159521404175031
HELO_3226;0.7681073517638716;0.7600715357093071;0.6280948477360814;0.7381144307444001;0.6565898874356466;0.7808595047314864;0.25326377156531726;0.10219038010077477;0.2105108078696479;0.050968450190667605;0.26034423597393064;0.208199555720295;gspK2;general secretion pathway protein GspK;COG3156;Type II secretory pathway, component PulK;PulK;HELO_RS12240;U;gspK2; general secretion pathway protein GspK;;gspK2;general secretion pathway protein GspK;0.006571805108466333;-0.1293889551013312;-0.10435721714244361;-0.010367832537596544;-0.016939637646062877
HELO_3227;1.2010274742196667;1.0777820103222886;1.1419526733746892;0.8300222181603387;1.1932000711753756;1.4587986830887765;0.20860514533613003;0.1485436079966195;0.21829277936431993;0.29961590065399313;0.3568801147002863;0.2435462852055557;HELO_3227;uncharacterized protein;COG3297;Type II secretory pathway, component PulL;PulL;HELO_RS12245;U;;gspK2;;HELO_3227;uncharacterized protein;0.08313285131141557;-0.19902701351673846;-0.1649161919214508;-0.159776463774846;-0.24290931508626157
HELO_3228;0.961950724484101;0.820962249346543;0.6061982178804958;0.37283377755893543;0.2736613604226551;0.5537502590870486;0.0987288373309898;0.22069929053617474;0.460698697594631;0.2106502732427624;0.22949738114167129;0.5000913696275038;HELO_3228;uncharacterized protein;;;;;;;;;HELO_3228;uncharacterized protein;0.10758779401206886;0.04789531225854893;-0.286772885320631;0.3365341760536663;0.22894638204159745
HELO_3229;0.9268767196701257;1.0354321477573445;1.4102130615013202;1.9224308773720298;0.9091470060217381;1.0067310211255631;0.24823544019449933;0.24686400389220137;0.24984084739501378;0.0702517513063588;0.35362601078717865;0.01953242089263989;HELO_3229;uncharacterized protein;;;;;;;;;HELO_3229;uncharacterized protein;-0.07907085736421349;0.26431343231043347;-0.07191905740204863;-0.05858298133767714;0.020487876026536345
HELO_3230;7.265162767649645;2.5879578956239757;6.890209667383936;5.791726083728432;7.967657992589184;6.013409917921568;1.2256854350243405;0.10610187169633253;1.231365607633359;0.48131186074263277;0.9944066455868946;0.528062816423121;sirA2;uroporphyrin-III C-methyltransferase;COG0007;Uroporphyrinogen-III methylase (siroheme synthase);CysG;HELO_RS12260;H;sirA2; uroporphyrin-III C-methyltransferase;2.1.1.107;sirA2;uroporphyrin-III C-methyltransferase;1.2038802706500464;0.169947584905342;0.35461520513866107;0.23692717837272648;-0.96695309227732
HELO_3231;2.907616662816645;0.9744309980323868;1.7513686329727598;2.4775108937921657;2.0141650228665617;1.4411482720755062;0.2871362133199853;0.16187442750664235;0.48557770309012244;0.36640777736712593;0.4079770639321304;0.4686241624192762;nasA;nitrate reductase catalytic subunit;COG3383;Predicted molibdopterin-dependent oxidoreductase YjgC;YjgC;HELO_RS12265;R;nasA; nitrate reductase catalytic subunit;1.7.99.-;nasA;nitrate reductase catalytic subunit;0.9848519961689428;0.1725895221553193;0.3041984802300157;0.6787290207241745;-0.3061229754447683
HELO_3232;0.8279590641468095;1.3463172497861409;0.7253918014209102;0.7530850159326116;0.19128340364448584;0.5081687298592754;0.25696856936643314;0.1553212966886137;0.09396669382542712;0.3685796788025011;0.18011118738865364;0.16527396067096153;HELO_3232;response regulator/HTH domain transcription regulator;COG3707;Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains;AmiR;HELO_RS12270;KT;;nasA;;HELO_3232;response regulator/HTH domain transcription regulator;-0.3601643333328959;0.19412616334824062;-0.34028117453376616;0.27743592014530105;0.6376002534781969
HELO_3233;1.9978938042103558;2.1625409403355373;1.7350909933074068;2.6099348233784023;0.9723511597184079;1.4483902936779074;0.2863037256984519;0.6455050921386792;0.36405399993664533;0.2914130756276631;0.21882363850990327;0.5205451039910398;HELO_3233;ABC-type transport system periplasmic substrate-binding protein (probable substrate nitrate/nitrite);COG0715;ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component;TauA;HELO_RS12275;P;;;;HELO_3233;ABC-type transport system periplasmic substrate-binding protein (probable substrate nitrate/nitrite);-0.07713487725021051;0.1597552767149486;-0.31191712018840034;0.2921157250387503;0.3692506022889608
HELO_3234;0.6062709941393486;0.4622393763861245;0.17753593252524977;0.3859806592501919;0.32857987396166627;0.32745369603703994;0.13088254716715378;0.11204342467381292;0.1788159859802198;0.20081996812430838;0.16199272066674097;0.1263858672590889;nasC;nitrite reductase electron transfer subunit;COG1251;NAD(P)H-nitrite reductase, large subunit;NirB;HELO_RS12280;C;nasC; nitrite reductase electron transfer subunit;1.7.1.15;nasC;nitrite reductase electron transfer subunit;0.13553580311499802;-0.17289045375071377;0.001223426859310206;0.2750537724937262;0.13951796937872818
HELO_3235;1.235404538660105;0.6858759275861313;0.5739389083986316;0.7450825041596544;0.7335555281004749;0.5520531505336056;0.14053081263197095;0.027804868913414313;0.0714482457939622;0.1035067867515038;0.08958929133999341;0.10772234389293477;nirB;assimilatory nitrite reductase (NADH) large subunit;COG1251;NAD(P)H-nitrite reductase, large subunit;NirB;HELO_RS12285;C;nirB; assimilatory nitrite reductase (NADH) large subunit;1.7.1.15;nirB;assimilatory nitrite reductase (NADH) large subunit;0.4070375732195697;0.020201580588857793;0.15955608482840777;0.5263579740411596;0.1193204008215899
HELO_3236;2.0333506404411836;1.2805236049727104;2.3032732316162385;2.020641961902275;2.167502914839262;1.6185409301949745;1.0751340638964237;0.19079687830998132;0.7276822439658585;0.8321098461382982;0.35630782338455286;0.43604129079584736;nirD;assimilatory nitrite reductase (NADH) small subunit;COG2146;Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase;NirD;HELO_RS12290;PQ;nirD; assimilatory nitrite reductase (NADH) small subunit;1.7.1.15;nirD;assimilatory nitrite reductase (NADH) small subunit;0.4115471729158282;0.3351331520686742;0.2745827913722041;0.2121491204557393;-0.1993980524600889
HELO_3237;40.240484604850984;9.21659301443308;37.804494982795326;62.87038883584259;50.3467319001601;31.140510142656538;1.7542112797037692;0.7052283800028664;9.287376310027026;9.26168619683418;14.902815029890094;3.6040136995289136;HELO_3237;YlaK family protein;COG1875;Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains;YlaK;HELO_RS12295;R;;nirD;;HELO_3237;YlaK family protein;2.013147112763519;0.27183095102514976;0.6758796272568377;0.3596684574612876;-1.6534786553022314
HELO_3238;545.048198028211;642.1464936287639;269.47366578357287;226.10564765299776;206.79863881502772;279.42813099594076;46.898763174405836;53.70870335484129;48.793051946446084;15.311419966044404;61.28954388697934;49.0553753587109;HELO_3238;uncharacterized protein;;;;;;;;;HELO_3238;uncharacterized protein;-0.23611908783956181;-0.05214294448061452;-0.432444875879586;0.9613972193284592;1.197516307168021
HELO_3239;131.57775543380703;89.18582759817669;127.9115917400466;115.0943739905025;121.61043432683148;140.69607045513513;4.970356840089993;5.305581784382852;6.874251417303626;7.547977995002805;7.194727280045352;3.925711064288432;estB;carboxylesterase;COG0400;Predicted esterase;YpfH;HELO_RS12305;R;estB; carboxylesterase;;estB;carboxylesterase;0.5558660913921631;-0.13641775291279856;-0.20871798998624946;-0.0959610166056244;-0.6518271079977875
HELO_3240;29848.278355964776;7532.0664461015285;29903.486635160065;28694.178781117862;14927.795732882316;25118.09797132791;4043.853771135237;1666.8360935294231;4695.876931673495;9247.36495047107;723.0558196949075;2938.760447871153;cspA2;cold shock protein CspA;COG1278;Cold shock protein, CspA family;CspC;HELO_RS12310;K;cspA2; cold shock protein CspA;;cspA2;cold shock protein CspA;1.986386893012563;0.25157729346280533;-0.7506868661636545;0.2489113950616968;-1.7374754979508662
HELO_3241;19.807140191457425;10.350310289384149;37.16517508446707;42.03009293907945;76.66186739805575;35.323574323827046;2.9686452119101157;0.48669698739285844;5.90265889773175;2.267203694019409;5.635765616603494;2.4498084472173756;HELO_3241;GMC family oxidoreductase (homolog to choline dehydrogenase);COG2303;Choline dehydrogenase or related flavoprotein;BetA;HELO_RS12315;IR;;cspA2;1.1.99.1;HELO_3241;GMC family oxidoreductase (homolog to choline dehydrogenase);0.8743469517125035;0.07135063562639843;1.0963002234615935;-0.8038274846683064;-1.67817443638081
HELO_3242;129.91751714606747;25.203582310071226;152.30165780064704;120.58730928592628;133.32696926579203;148.80753303357812;9.584735284832702;1.287954644093654;10.269466256391535;5.02513953181612;14.82258688169134;9.238752181995547;HELO_3242;glutamate synthase domain protein;COG0069;Glutamate synthase domain 2;GltB2;HELO_RS12320;E;;;;HELO_3242;glutamate synthase domain protein;2.320822184800945;0.033263127179717245;-0.15736118271515842;-0.1944520241649217;-2.5152742089658666
HELO_3243;275.4719203159206;16.787119690956793;73.95236639048603;124.17611708177203;63.735545157923696;68.18598076455221;14.3035405481774;2.7035829665843045;6.583426030301302;14.498159432651127;5.389261961259155;2.6065428249195035;HELO_3243;uncharacterized protein;;;;;;;;;HELO_3243;uncharacterized protein;3.9582281458342203;0.1154942950434199;-0.09592164406511117;1.9985813239308712;-1.9596468219033492
HELO_3244;26.802456177812502;9.638304783488294;16.45247319596079;23.046994305900586;16.73892056520073;17.874695698590646;4.5544820419909495;2.168026837068935;2.4294022034381517;2.761547988899834;0.886662813434978;4.341050859755871;HELO_3244;PepSY domain protein;COG3212;PepSY domain containing protein, regulator of zincin peptidase activity;YkoI;HELO_RS12330;O;;;;HELO_3244;PepSY domain protein;1.3859440665657865;-0.11302188949205494;-0.08953516265374883;0.5587589566831266;-0.8271851098826599
HELO_3245;117.00450076441791;45.972717029181645;35.055929705639635;46.45855652196641;40.424411468692476;37.3658367346358;2.0753308921337696;3.5949332949886768;1.9225918294380189;3.686868733409975;3.4063526444070953;4.117610878732541;HELO_3245;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS12335;KT;;;;HELO_3245;response regulator/HTH domain transcription regulator;1.3289469354041836;-0.08958567700852971;0.11065898120199957;1.620947761292105;0.2920008258879214
HELO_3246;36.936567294677296;16.69052511078799;17.945872625338307;22.01144124546738;20.21862952356533;16.63568992041411;0.6209072934768588;1.3640432910688363;1.7063749678382967;2.1694076533294893;2.8711523061158433;1.7377782884780828;HELO_3246;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS12340;T;;;;HELO_3246;sensor histidine kinase;1.1006122694028564;0.10338557417098215;0.26683346186014667;1.1050911257245621;0.004478856321705749
HELO_3247;98.22129721793266;120.40379069383584;57.19785960387751;24.4204829883917;41.713163422451906;54.84265283492267;2.4433654046380875;11.94647862336154;5.634978712352548;1.4732340681851392;5.230902805515385;3.8269085091548485;HELO_3247;HPP domain protein;COG3448;CBS-domain-containing membrane protein;;HELO_RS12345;T;;;;HELO_3247;HPP domain protein;-0.29109174454895737;0.059598615618229545;-0.38668672834884354;0.8292823399591027;1.12037408450806
HELO_3248;137.16412977014912;59.35204797866032;107.8040191865049;122.62114450135687;122.3804811090543;109.16232607533442;6.4842743325156444;1.8619466082258782;8.609999118406481;4.65645446725626;9.953409141337533;5.088788929215235;HELO_3248;phosphatase domain protein;;;;;;;;;HELO_3248;phosphatase domain protein;1.1949084780892312;-0.01789907710730798;0.16348324964344751;0.32675218385706106;-0.8681562942321701
HELO_3249;41.60590843940963;34.9980603952193;89.19264344305525;81.72809079204177;104.9800068953732;75.88511380248896;4.285733500693879;3.176734711037247;8.646322989148151;6.126180944302898;16.890258638441004;11.59165953413616;HELO_3249;DUF2872 domain protein;;;;;;;;;HELO_3249;DUF2872 domain protein;0.2431343371959418;0.23030546874760294;0.46301592504021727;-0.8516507839445797;-1.0947851211405215
HELO_3250;64.49943126830993;31.892016347392968;71.0101892857551;68.79241452873386;60.39465893262278;71.22494665030369;0.7863821584056082;0.1801306226369449;8.684701224436262;5.0478943741102595;2.264569751706421;0.8278172778609625;chaC;glutathione-specific gamma-glutamylcyclotransferase;COG3703;Gamma-glutamylcyclotransferase ChaC2 (glutathione degradation);ChaC2;HELO_RS12360;P;chaC; glutathione-specific gamma-glutamylcyclotransferase;4.3.2.7;chaC;glutathione-specific gamma-glutamylcyclotransferase;0.9937449287608411;-0.004296173907640366;-0.23438408024643298;-0.14101485334821628;-1.1347597821090574
HELO_3251;118.61016846690895;52.306792622882796;159.38579526053627;166.82712764117318;141.91333646047087;147.28351812325067;5.508724329688242;2.9099804915492333;9.807464636560516;10.826411433104646;11.951771751961955;8.499593068569196;tdcB;L-threonine dehydratase;COG1171;Threonine deaminase;IlvA;HELO_RS12365;E;tdcB; L-threonine dehydratase;4.3.1.19;tdcB;L-threonine dehydratase;1.1659487578009307;0.11318812406444678;-0.053217696681164384;-0.3100182063992163;-1.475966964200147
HELO_3252;300.5954370487697;167.9999227582992;324.3204449759971;287.25501104655586;448.69870921909154;343.21296286827715;10.466930278350807;2.4445905869795914;16.74664651972303;9.195572538724138;18.90037270297984;27.411034094012933;HELO_3252;probable oxidative decarboxylase (homolog to isocitrate dehydrogenase);COG0538;Isocitrate dehydrogenase;Icd;HELO_RS12370;C;;tdcB;1.1.1.42;HELO_3252;probable oxidative decarboxylase (homolog to isocitrate dehydrogenase);0.8355920145723479;-0.08143993715111009;0.38565731351886257;-0.19068682779834845;-1.0262788423706963
HELO_3253;266.7651252292807;174.02312870278652;104.55044495664463;67.75446571317798;122.60887634130188;100.9937368480736;14.367570444778627;13.233834015616722;5.644646658590981;3.654774118529594;6.160767165960835;7.673042518865857;HELO_3253;UPF0060 family protein;COG1742;Uncharacterized inner membrane protein YnfA, drug/metabolite transporter superfamily;YnfA;HELO_RS12375;R;;;;HELO_3253;UPF0060 family protein;0.6134224888587463;0.04945209747462709;0.27730178372805625;1.3924875076640824;0.7790650188053361
HELO_3254;19.27605618671161;18.799282127595127;4.3891119904307;4.023363586561987;7.38178751550015;7.212694359642058;2.1404467343671634;1.7268691761402004;1.2677686322947301;0.6072737149595844;0.5965038626632242;0.7830311936839477;HELO_3254;MerR family transcription regulator;COG0789;DNA-binding transcriptional regulator, MerR family;SoxR;HELO_RS12380;K;;;;HELO_3254;MerR family transcription regulator;0.03432894413617049;-0.6078080408155957;0.029402340236482694;1.3038495534545813;1.2695206093184108
HELO_3255;2.9693871327028094;3.049169531436488;1.9058729500518847;3.0122317413777844;3.16776519175395;2.147268117825245;0.4806672310436284;0.2378145132734104;0.6684397536789878;0.13110702605281113;0.4376461781424402;0.06342356941947132;HELO_3255;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS12385;G;;;;HELO_3255;major facilitator superfamily transport protein;-0.028709772665565847;-0.11512846085463946;0.4051739117250588;0.33481618665267665;0.3635259593182425
HELO_3256;62.8900690424648;20.432943092085036;49.046414339059176;52.51902639154827;52.842475047891035;50.03059438868585;2.2761589810325416;1.03929449845738;5.534575806005644;1.0522948772168454;2.5610387145882725;2.33939643505752;HELO_3256;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS12390;K;;;;HELO_3256;LysR family transcription regulator;1.5757617295358486;-0.02809573747837124;0.07738228384471224;0.3242292527850932;-1.2515324767507554
HELO_3257;3.9320419247348646;2.103501363881224;5.909002558472962;5.188412073727843;96.69350063297765;6.01743930726123;0.3594175558105855;0.48240690088317356;0.7599131387559004;0.21555062022456914;9.498070174034996;1.2025610706640348;HELO_3257;peptidase M20 family protein;COG1473;Metal-dependent amidase/aminoacylase/carboxypeptidase;AbgB;HELO_RS12400;R;;;;HELO_3257;peptidase M20 family protein;0.6682882834628132;-0.022467235050759093;3.7992459993066876;-0.5087596177507492;-1.1770479012135624
HELO_3258;2.0504662876365383;1.3519021116751564;2.587704233088783;1.0824656159422743;19.84863276389419;2.485301974872503;0.5516575877185763;0.5519419228183766;1.2273556312153768;0.5947796835901183;9.804856453329494;0.5177613301092961;HELO_3258;DUF3311 domain protein;;;;;;;;;HELO_3258;DUF3311 domain protein;0.37520177162352697;0.041777300710719834;2.5805972108639748;-0.1922538732915866;-0.5674556449151136
HELO_3259;3.815101040332916;2.7455160942414523;9.026831028891669;8.683933989220435;104.54674423494002;9.63747275862383;0.13223559825808923;0.17658019559872878;0.7582957949463899;0.4838310968912334;4.962585940573779;1.5362553969018768;HELO_3259;SSS family transport protein;COG0591;Na+/proline symporter;PutP;HELO_RS12410;E;;;;HELO_3259;SSS family transport protein;0.3624015508065339;-0.08528972184336636;3.3106547345926116;-1.1435174602481184;-1.5059190110546523
HELO_3260;24.062943662821677;9.162256173180351;18.917349957661543;23.411828047805432;19.578989043465594;19.861071079568276;1.3325542686943366;0.4020472506638731;2.2570411152595797;0.8719804228488098;1.6326753261726619;0.9421735310702805;HELO_3260;sigma-54-interact/HTH domain transcription regulator;COG3829;RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains;RocR;HELO_RS12415;KT;;;;HELO_3260;sigma-54-interact/HTH domain transcription regulator;1.30233513270728;-0.06678752593448412;-0.019641122095916508;0.2647426375857913;-1.0375924951214888
HELO_3261;5.475449204182983;3.6548722118027386;7.293223720379324;9.257500995719852;7.132228252725071;7.004937711310625;0.2991366915254314;0.47247611726803285;0.37314153743477174;1.0162881011280775;0.33045711396771427;0.5088627437522187;HELO_3261;SSS family transport protein;COG0591;Na+/proline symporter;PutP;HELO_RS12420;E;;;;HELO_3261;SSS family transport protein;0.4762387138881894;0.051042834647879065;0.022760532077723994;-0.3059099002343957;-0.7821486141225851
HELO_3262;4.965693085753387;4.721843253643283;2.173890568273332;2.2760160969269863;1.773859364598154;2.967104794372721;0.9836952591062316;1.1200907089895116;0.49237980711503465;0.4869265980283958;1.33573058308562;1.0894100296848235;HELO_3262;uncharacterized protein;;;;;;;;;HELO_3262;uncharacterized protein;0.060209781455168976;-0.3218341212430569;-0.5161918634796319;0.5886032499433183;0.5283934684881493
HELO_3263;4.639811566341903;2.7580735185408485;3.1479556486998823;3.9755250155588304;3.5348558506501213;3.417731782691726;0.15964251484347394;0.17670515566253006;0.33022970270337587;0.3570201962560478;0.19256561422993318;0.6879374844896333;HELO_3263;homolog to acetylornithine deacetylase;COG0624;Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase;ArgE;HELO_RS12430;E;;;3.5.1.16;HELO_3263;homolog to acetylornithine deacetylase;0.5856536708286639;-0.09090536138016247;0.03775086272538308;0.3523411312097622;-0.23331253961890175
HELO_3264;6.008892542733793;3.5925393687514133;3.671243634392338;4.254012915596587;3.600770410720921;3.6830579008235573;0.8213280131096159;0.1519528978704475;0.4712076540319068;0.514180094514448;0.28060505064752983;0.07582028860750224;HELO_3264;probable amidase (homolog to N-carbamoyl-L-amino acid hydrolase);COG0624;Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase;ArgE;HELO_RS12435;E;;;3.5.1.6,3.5.1.87;HELO_3264;probable amidase (homolog to N-carbamoyl-L-amino acid hydrolase);0.6098944170291052;-0.003644182858648204;-0.025575411116265823;0.581735630199709;-0.02815878682939621
HELO_3265;55.59233139736409;21.52676670588507;12.489907477365584;20.010997488803735;16.84331792413168;12.08440283698017;11.434822567843236;0.6577942162797675;0.48898821402873976;0.915102496768833;0.8470041910664811;0.8412260636706427;HELO_3265;PepSY domain protein;COG3182;PepSY-associated TM region;PiuB;HELO_RS12440;S;;;;HELO_3265;PepSY domain protein;1.3289663157459346;0.04403237107819846;0.4475358237511493;2.1127584901185754;0.7837921743726408
HELO_3266;152.0836680105522;62.151196529220634;50.979307653982666;96.17147980504679;83.5185500608717;47.61612783846539;12.60552038614281;3.702109190206452;2.8351346945444127;1.8082735071836233;2.3068185649538546;0.6368231728367691;HELO_3266;DUF2946 domain protein;;;;;;;;;HELO_3266;DUF2946 domain protein;1.277438400485246;0.09650242711258716;0.7978330270150984;1.6548134789427724;0.3773750784575265
HELO_3267;48.41082587792423;26.98684645427831;38.029335390577444;51.54096367240263;42.56620651931573;33.604663993373634;1.7991488568196807;1.3636228190907687;1.1667022033307997;4.45477158330783;2.514807690456635;1.2969959897241978;HELO_3267;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS12450;G;;;;HELO_3267;major facilitator superfamily transport protein;0.8200782361156316;0.1735923996776947;0.3322430011637785;0.5138606734973905;-0.30621756261824107
HELO_3268;47.6210839531106;116.50809726654126;62.88004432063661;93.17687285241338;63.91664627125161;63.64485234462304;4.495365000582124;1.5160298228982159;10.522274689236385;9.429814163813228;8.024772141673482;2.7945397302179615;sstT;SDF family transport protein (probable substrate serine/threonine);COG3633;Na+/serine and Na+/threonine symporter SstT;SstT;HELO_RS12455;E;sstT; SDF family transport protein (probable substrate serine/threonine);;sstT;SDF family transport protein (probable substrate serine/threonine);-1.2731062115508136;-0.017170179414160103;0.006052976069026883;-0.41095343611031154;0.8621527754405021
HELO_3269;114.29734247232966;69.83749041368485;148.5076205261224;174.12939830764734;188.44451560880728;153.73056834111966;2.0394018185309926;1.6223207372916166;11.434469600124219;7.310443157210526;10.510596191896653;7.977108846907045;gpr;L-glyceraldehyde 3-phosphate reductase;COG0667;Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family;PdxI;HELO_RS12460;HR;gpr; L-glyceraldehyde 3-phosphate reductase;1.1.1.-;gpr;L-glyceraldehyde 3-phosphate reductase;0.7027742529940886;-0.04953921998471866;0.2920171330068895;-0.42439898142841237;-1.127173234422501
HELO_3270;24.10764355379298;17.14062916307645;27.3184824189786;23.924023399278713;19.91858272448573;31.32089021650324;2.5602363324561677;1.8360864049236552;2.3941444719161793;1.2513127077485267;2.2094492247239734;2.0756803196320726;HELO_3270;PuuR family transcription regulator;COG1917;Cupin domain protein related to quercetin dioxygenase;QdoI;HELO_RS12465;R;;gpr;;HELO_3270;PuuR family transcription regulator;0.4689021395792192;-0.19072298109185315;-0.6276818254433509;-0.3643403022454992;-0.8332424418247184
HELO_3271;29.313111387765364;18.481290256115518;26.505709949354188;22.052883786919455;21.89150244121234;27.56749132164471;1.6775239601964793;1.6820243963290533;1.74655496375971;2.6746648667322606;3.9428139676711598;3.0367607690599665;HELO_3271;YgaZ family protein;COG1296;Predicted branched-chain amino acid permease (azaleucine resistance);AzlC;HELO_RS12470;E;;;;HELO_3271;YgaZ family protein;0.6378527092845507;-0.05464320951641355;-0.31956219574593714;0.08556758996725211;-0.5522851193172986
HELO_3272;33.11173342525305;22.18250298232573;28.22790605695137;37.74405333623127;29.289467840347708;30.72124169283373;1.0673899789514294;2.5150006353781875;2.036863648747822;3.9204075128042404;2.799664215110357;1.6823816105442468;HELO_3272;AzlD family transport protein;;;;;;;;;HELO_3272;AzlD family transport protein;0.5572317284358084;-0.1181027694286989;-0.06663301338828376;0.10481882410447874;-0.45241290433132963
HELO_3273;394.009249147995;436.13696322727884;295.80009291731125;240.17928544689337;248.85901028572528;342.56723796322746;19.738843854937922;27.855614920869556;24.215999559123006;21.388924141501953;32.92000480216413;36.112190386249445;HELO_3273;LpxT family protein;;;;;;;;;HELO_3273;LpxT family protein;-0.14619893961541486;-0.21110092626884303;-0.4594782251525782;0.20129396453012838;0.34749290414554324
HELO_3274;132.99351528141838;135.60253371029495;119.60517088901382;127.66082255441977;113.13330660258981;116.87642060643428;2.612611100236783;7.18951436432579;11.716574442610854;8.853988007635374;7.8515774854106155;12.80257033024845;HELO_3274;uncharacterized protein;COG3307;O-antigen ligase;RfaL;HELO_RS12485;M;;;2.4.1.-;HELO_3274;uncharacterized protein;-0.027821061009075443;0.03301660554991326;-0.04655529474430331;0.18488802416943262;0.21270908517850806
HELO_3275;103.95262521133246;84.0542997030712;106.46183226910227;148.32018679243723;114.22265528720932;108.70146384267703;2.288134096793432;2.695250768373535;3.3841320747155814;4.84985098342271;5.17944605377802;4.2615494390619055;HELO_3275;probable glycosyltransferase%2C type 1;COG0438;Glycosyltransferase involved in cell wall bisynthesis;RfaB;HELO_RS12490;M;;;;HELO_3275;probable glycosyltransferase%2C type 1;0.3032821790319824;-0.02975843509246978;0.07084163297109125;-0.0638445233696201;-0.3671267024016025
HELO_3276;56.385335135304636;60.7953642826324;61.982003071446314;67.2972078438484;61.76520926857299;62.37553434618594;2.3660489552579236;2.8608918959082787;1.3336710739392679;4.53001928869192;1.736893063349403;0.4411718857948151;HELO_3276;LmbE family protein;COG2120;N-acetylglucosaminyl deacetylase, LmbE family;LmbE;HELO_RS12495;G;;;;HELO_3276;LmbE family protein;-0.10681651297568973;-0.008986364656362156;-0.013960910785277392;-0.14324390392484432;-0.03642739094915459
HELO_3277;34.081784346839214;16.931525575495236;17.46058591467578;16.316085968025735;13.90212833394172;16.229275915520855;1.8162661752669598;0.3940246402507004;2.874874170498537;1.2482848744030968;1.2618377378346446;2.5514789882021316;HELO_3277;gluconate 2-dehydrogenase (acceptor) flavoprotein subunit;COG2303;Choline dehydrogenase or related flavoprotein;BetA;HELO_RS12500;IR;;;1.1.99.3;HELO_3277;gluconate 2-dehydrogenase (acceptor) flavoprotein subunit;0.9682238938999426;0.09958627139539633;-0.20934367928725495;1.0258600571533432;0.057636163253400596
HELO_3278;29.299298785244932;10.845118230647026;12.041373964179916;9.44044698569964;8.957110386385905;12.641534023416392;1.8176183655960703;0.26580276313792195;1.546688991346305;0.9311786905242434;1.4555307674917488;1.7679793162978674;HELO_3278;gluconate 2-dehydrogenase (acceptor) cytochrome subunit;COG2010;Cytochrome c, mono- and diheme variants;CccA;HELO_RS12505;C;;;;HELO_3278;gluconate 2-dehydrogenase (acceptor) cytochrome subunit;1.35499180714453;-0.06491001639206484;-0.4542068586976007;1.151278517861496;-0.203713289283034
HELO_3279;43.27026084628621;17.58882571267699;17.23444161245746;12.302308555652859;12.009575125841238;15.220238595363204;1.9096702102303749;0.08751274452948044;1.368453585918618;1.1503301114663633;1.4159899522595647;1.3733131726072938;HELO_3279;gluconate 2-dehydrogenase (acceptor) subunit 3;;;;;;;;;HELO_3279;gluconate 2-dehydrogenase (acceptor) subunit 3;1.251902238344056;0.1688709797874548;-0.31822119490494405;1.448542832643854;0.1966405942997982
HELO_3280;49.954331202421734;8.594243736040557;14.531957254474834;17.73504750999658;14.92108771028606;8.745039995674036;7.130547941601054;1.5771056990741843;2.7825742334692056;3.8415292096343947;2.030483214660591;4.183590425607003;HELO_3280;short-chain dehydrogenase family protein;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS12515;I;;;;HELO_3280;short-chain dehydrogenase family protein;2.4089637871430125;0.672499630192176;0.7081988907751509;2.386464771338848;-0.02249901580416447
HELO_3281;7.486330717383885;0.6432468429653447;2.3190431949566075;5.885880149997656;1.3369140383000468;1.5760640824068375;0.5928288125225367;0.10121549064892084;0.5306868343285401;0.48942482291257927;0.06735825742094656;0.4073622509460648;HELO_3281;sulfate transport domain protein;COG0659;Sulfate permease or related transporter, MFS superfamily;SUL1;HELO_RS12525;P;;;;HELO_3281;sulfate transport domain protein;2.3685916890919008;0.36559892266189786;-0.14056381591468714;1.719972419899506;-0.6486192691923947
HELO_3282;11.21030631520184;18.74318414520855;51.563792532183676;49.722195962686065;115.5171930993431;72.12289325426896;1.9372236068922066;2.464149829052422;4.312581162740522;2.574236619583409;15.085366609127274;25.08497466569664;HELO_3282;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS12530;G;;;;HELO_3282;TRAP transporter substrate-binding protein;-0.6932552907106948;-0.476253783294756;0.6721477927002457;-2.5822237615465906;-1.8889684708358958
HELO_3283;3.9067064123830892;7.839148394068553;6.6966147472192645;6.452055728422433;16.98577941556005;10.069533987536323;0.8319577026264252;2.317368697819322;1.3706543687349275;1.0162639624492087;2.93707221881584;3.6648844321170704;HELO_3283;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS12535;G;;;;HELO_3283;TRAP transporter small transmembrane protein;-0.8491524283071819;-0.5242985475187747;0.7002621922818695;-1.1737676309198668;-0.32461520261268495
HELO_3284;3.660907425194317;6.37555407837294;7.775472128570211;8.002935500208618;16.815210945898553;10.129807611623278;0.15266847465535938;0.5701040211226862;1.4431958298530125;0.5322627894270433;6.650180827853471;3.0090286707164755;HELO_3284;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS12540;G;;;;HELO_3284;TRAP transporter large transmembrane protein;-0.6621405755219176;-0.3428800037062878;0.6786809115387764;-1.2557458911527233;-0.5936053156308057
HELO_3285;3.8440664453516242;2.881331231129271;8.208298604689356;6.898617973968794;20.41261897612786;9.727293582814161;0.20747477361269545;0.23613706343756427;0.8093331199286714;0.25929493300392364;0.8491382599718352;1.7691410081167709;HELO_3285;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS12545;I;;;;HELO_3285;probable oxidoreductase (short-chain dehydrogenase family);0.3196670970568405;-0.22027961792538298;0.9971751217930107;-1.1469955811476966;-1.466662678204537
HELO_3286;3.2638450533082524;2.8103072884979006;7.934668992785361;6.049649839029198;16.47843506508669;8.860835550171219;0.4031275209537081;0.7819930426055688;0.7750613863336806;0.8258311715979463;1.2391495878441574;1.237675993272611;HELO_3286;3-hydroxyacyl-CoA dehydrogenase domain protein;COG1250;3-hydroxyacyl-CoA dehydrogenase;FadB;HELO_RS12550;I;;;1.1.1.45;HELO_3286;3-hydroxyacyl-CoA dehydrogenase domain protein;0.16224766107354438;-0.14229561541438907;0.825794216125022;-1.2095548854178966;-1.371802546491441
HELO_3287;11.376577631535305;9.74061376411458;19.84644769135299;16.59956379322512;41.14079738905689;23.312789825311786;0.5097245352788891;0.2652306756477834;0.5385768195046141;0.3807210488047278;4.43332147588801;4.368222322786836;HELO_3287;Kce family protein;COG3246;Uncharacterized conserved protein, DUF849 family;;HELO_RS12555;S;;;;HELO_3287;Kce family protein;0.2045359986124171;-0.22191388386636568;0.7935021649929803;-0.974103012136383;-1.1786390107488
HELO_3288;20.36396956679772;12.037838619287681;11.502387777377663;11.430307991052876;21.392179766400176;11.78686217428339;0.9165237818806907;1.0810244413212118;2.895138063158439;1.106671004902874;1.2104555380615825;1.1018717994134493;HELO_3288;YrdA family protein;COG0663;Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily;PaaY;HELO_RS12560;R;;;;HELO_3288;YrdA family protein;0.7124750112423652;-0.03245862287949741;0.8083326959382413;0.7405174559945538;0.028042444752188533
HELO_3289;88.02707872724977;32.279402779596204;38.36652971686094;54.30865463133852;52.04123013847006;40.660833670365264;4.54459329259742;0.9505924362807715;3.2398270272553575;1.1751480858762862;1.9762257992340175;2.207589598131798;HELO_3289;LacI family transcription regulator;COG1609;DNA-binding transcriptional regulator, LacI/PurR family;PurR;HELO_RS12565;K;;;;HELO_3289;LacI family transcription regulator;1.4196146734030695;-0.08172216927265552;0.34842252571280685;1.095552507739547;-0.32406216566352253
HELO_3290;9.587506570651142;7.331457034596421;11.071372775049085;12.636605030005176;16.304274718908616;11.918985474685238;0.6926343938360989;0.4568675514522398;1.0633013907539162;1.263157697816901;0.3046201914043052;0.7723040172386614;HELO_3290;TTT family transporter large transmembrane protein;COG3333;TctA family transporter;;HELO_RS12575;R;;glxK;;HELO_3290;TTT family transporter large transmembrane protein;0.3457221385344318;-0.09790302901249737;0.42163569457707695;-0.2871299150301514;-0.6328520535645832
HELO_3291;5.969986554337031;9.57786685513697;20.56681287468177;33.481574061924825;32.754394698535826;23.362288180884367;0.2317296476616632;0.8924316323699069;2.6643698198949437;1.9343101266461513;4.773728231585515;5.819262290060848;HELO_3291;TTT family transporter substrate-binding protein;COG3181;Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC;TctC;HELO_RS12585;C;;;;HELO_3291;TTT family transporter substrate-binding protein;-0.6018209430982102;-0.17583664995420278;0.47042570604685263;-1.8054218638199382;-1.203600920721728
HELO_3293;35.19153432661452;23.78837396595604;16.99371898576425;0.0;14.23704680439194;13.093592123771804;1.8091520729643427;1.4922913559157949;1.3956149595488514;0.0;2.0420269996750133;2.1101800740328893;HELO_3293;DUF1814 family protein;COG2253;Predicted nucleotidyltransferase component of viral defense system;;HELO_RS12640;V;;;;HELO_3293;DUF1814 family protein;0.545988632944618;0.3524540297324812;0.11254394398496315;1.3606129041175317;0.8146242711729137
HELO_3294;67.45317219193358;42.36126997129066;44.175866470689705;0.0;43.79333676027462;43.76832955091333;3.1571157099444602;2.351277259284908;1.8630716554572142;0.0;2.1035426726572424;2.956849038192565;HELO_3294;DUF2893 domain protein;;;;;;;;;HELO_3294;DUF2893 domain protein;0.6587103878601823;0.0130737844737574;0.0008056522250088349;0.6126389113417758;-0.046071476518406485
HELO_3295;96.24699061499028;65.74694090261761;72.96546570572075;0.0;68.43804331503532;60.63184454088107;4.520247824580284;3.4303543772573475;6.454108798519569;0.0;5.352682070415683;7.524617971669217;HELO_3295;dCTP pyrophosphatase;COG1694;NTP pyrophosphatase, house-cleaning of non-canonical NTPs;MazG;HELO_RS12650;V;;;;HELO_3295;dCTP pyrophosphatase;0.5429518876883028;0.26317586790114866;0.1720503255831609;0.6579776361818404;0.11502574849353753
HELO_3296;103.60826167414338;41.75167002277558;106.90193097724364;0.0;85.34307856219618;99.89476136015018;5.342013056028169;3.0553813252537827;6.697176780840512;0.0;10.965093193007828;11.349968105417553;HELO_3296;DUF2075 domain protein;COG3410;Uncharacterized conserved protein, DUF2075 family;BH3996;HELO_RS12655;S;;;;HELO_3296;DUF2075 domain protein;1.2909441134988704;0.09686941401628602;-0.2246988309173803;0.052145527155788685;-1.2387985863430817
HELO_3297;19.675404678221454;8.706997518975207;13.405765149363427;0.0;12.794355806202953;8.760467619635545;1.3264508084020388;0.6759387682287206;1.9656211761359754;0.0;3.443848752014471;2.1054306579350412;HELO_3297;probable DNA relaxase;;;;;;;;;HELO_3297;probable DNA relaxase;1.0908185391166838;0.5616241165624762;0.4990559112494779;1.0828933940097247;-0.007925145106959075
HELO_3298;46.69103889166583;23.085123419332508;20.70932246922196;0.0;28.487405978191248;23.138330963315596;3.000324505972625;2.2403403620237805;5.51180045425031;0.0;2.489974316144114;3.1456656372823573;HELO_3298;probable DNA relaxase;;;;;;;;;HELO_3298;probable DNA relaxase;0.9855758937009877;-0.15301122359875308;0.28877298849587874;0.9823922855594773;-0.003183608141510419
HELO_3299;59.470463207907734;24.614027889123495;35.93730804579979;0.0;35.72786543370003;33.47270966803848;0.7640820474187303;3.5609199807408545;4.125503206890486;0.0;1.8263290538829953;0.4009481477974049;HELO_3299;mobC domain protein;;;;;;;;;HELO_3299;mobC domain protein;1.2392964909163808;0.09962402425064365;0.09142034759462181;0.8107759264510435;-0.4285205644653374
HELO_3300;42.72988360832901;20.089635813457058;29.9451821927909;0.0;31.34247950281494;33.0359367838568;2.8365725135269084;2.8576412130325144;4.929772090600209;0.0;3.723085236477814;2.5568716436083423;HELO_3300;VirB6 family protein;COG3704;Type IV secretory pathway, VirB6 component;VirB6;HELO_RS12695;U;;;;HELO_3300;VirB6 family protein;1.0520853263841117;-0.1373440021357979;-0.07362853233678646;0.3615606904253843;-0.6905246359587274
HELO_3301;19.805176510460132;7.121632761786613;17.62966984858158;0.0;20.799379783392762;18.418782705136106;2.558902629320777;1.1623816189649727;2.141979032042766;0.0;3.2838566043131094;1.5002586379655118;HELO_3301;VirB5 family protein;;;;;;;;;HELO_3301;VirB5 family protein;1.3571008291222189;-0.05985065879516238;0.16683432316934077;0.09948976207593052;-1.2576110670462883
HELO_3302;56.854733546821;29.687369077784705;22.199037659462935;0.0;21.522846064445122;20.172356519476914;3.1079859404169157;1.8949689098612483;1.6250636616736482;0.0;1.0947646479965176;1.0295689966067703;HELO_3302;integrase family protein;COG4974;Site-specific recombinase XerD;XerD;HELO_RS12720;L;;;;HELO_3302;integrase family protein;0.9147900378531864;0.13188310813247028;0.08920729014770146;1.450253149584479;0.5354631117312927
HELO_3303;50.976953287582035;3.1181049611471234;32.27955226128136;41.81537614135485;34.35938233317196;27.843570209989096;3.4116522614398925;0.22036288725243952;0.42746417510625057;1.6244246751064975;7.953845660419243;1.45471676619081;HELO_3303;uncharacterized protein;;;;;;;;;HELO_3303;uncharacterized protein;3.6578195638335287;0.2063862737140445;0.2938433235134479;0.8496223203403224;-2.8081972434932063
HELO_3304;63.03372960147647;39.245551458455445;89.10111249142018;34.847181784451614;77.8397122436851;164.29207004341637;4.213194964707564;1.4410996699852856;51.84529003167339;10.0725604104854;8.401475820895195;190.90418573564278;iutA;TonB-dependent receptor IutA (probable substrate ferric enterobactin);COG1629;Outer membrane receptor protein, Fe transport;CirA;HELO_RS12735;P;iutA; TonB-dependent receptor IutA (probable substrate ferric enterobactin);;iutA;TonB-dependent receptor IutA (probable substrate ferric enterobactin);0.67000271745097;-0.8754006879640635;-1.0680230965643043;-1.3681135660643609;-2.038116283515331
HELO_3305;25.70718816400527;9.86712885115224;13.772697782202902;7.578090532982096;11.784229357153558;18.19450644740634;1.6447861610634742;1.4834450678674926;9.971421059289368;1.195609089182508;1.6349210935194691;17.632604641048246;HELO_3305;FhuF family protein;COG4114;Ferric iron reductase protein FhuF, involved in iron transport;FhuF;HELO_RS12740;P;;iutA;;HELO_3305;FhuF family protein;1.2972572678686705;-0.377760149962163;-0.5863282678533688;0.47653462713356287;-0.8207226407351076
HELO_3306;22.470134168863712;5.938694943946456;10.191372883442043;6.63715658520598;11.073255546138276;11.970438579447245;1.8260362195446482;0.9340495727168131;7.719906161162396;1.265537536508194;1.4385537291884005;10.5065725584555;HELO_3306;PchR family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS12745;K;;;;HELO_3306;PchR family transcription regulator;1.7580898432864118;-0.2128402359398276;-0.10341251296777987;0.8555988257891158;-0.902491017497296
HELO_3307;1.5090292747021277;0.6415427000571606;1.3941029226333317;0.8306793810755956;1.17711223598377;1.541682527960406;0.17386739284089478;0.009000018124158888;0.4709153451052162;0.301108273680652;0.1741008549183779;1.481456435044945;HELO_3307;TonB-dependent receptor;COG4773;Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid;FhuE;HELO_RS12750;P;;;;HELO_3307;TonB-dependent receptor;0.6120770258356968;-0.08629866480102688;-0.22336805571712337;-0.01865453612860213;-0.6307315619642989
HELO_3308;11.87694335524524;4.557107882125916;8.320375709250088;9.44907167347312;7.126104671398323;6.473418109252271;1.1571373260626543;0.19020329009431103;0.7787188656997324;1.3789488410693485;0.5852820301130977;0.8807036124565928;HELO_3308;sterol desaturase domain protein;COG3000;Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily;ERG3;HELO_RS12755;I;;;;HELO_3308;sterol desaturase domain protein;1.2123840233316567;0.318619874002775;0.12079571002845402;0.7849500336022;-0.4274339897294568
HELO_3309;31.874739474440346;23.81726436851304;37.392930423345966;44.62314138717204;39.01714459639094;33.15379739799325;3.1421649035855443;0.6293023058177847;4.359975136521519;3.3171248892123795;5.196978341547561;2.8518364341220086;HELO_3309;probable S-adenosylmethionine-dependent methyltransferase;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS12760;H;;;;HELO_3309;probable S-adenosylmethionine-dependent methyltransferase;0.40563536685053503;0.16879468738210957;0.22857223430261175;-0.055066532432442195;-0.4607018992829772
HELO_3310;80.37963562773092;55.14530710611169;98.52216336691212;88.3856670654077;101.1289455199726;102.15917608596429;0.995173270042364;2.9945979767098816;7.467962727915406;1.715127908593154;7.262663656096491;8.927413822085951;HELO_3310;ABC-type transport system ATP-binding/permease protein;COG1132;ABC-type multidrug transport system, ATPase and permease component;MdlB;HELO_RS12765;V;;;;HELO_3310;ABC-type transport system ATP-binding/permease protein;0.5355023805500894;-0.05178240417467439;-0.014480341040959743;-0.34213242977527347;-0.8776348103253628
HELO_3311;2989.218058835144;2008.7469796029238;3982.5899464921627;2954.7997621097948;3690.708014770813;3530.302404307234;228.09996055079003;181.06578297823242;399.6119340173641;240.79396520976832;441.83787936765435;428.96860505681013;sodA;superoxide dismutase (Mn);COG0605;Superoxide dismutase;SodA;HELO_RS12770;P;sodA; superoxide dismutase (Mn);1.15.1.1;sodA;superoxide dismutase (Mn);0.5732368130617385;0.17386877818687196;0.0640880795238381;-0.2399496766419258;-0.8131864897036643
HELO_3312;145.6932230034908;52.61555871394538;128.46000969881936;130.5312976987108;120.88423722108878;148.54672090588141;4.432139330952432;0.7543091162480707;54.756416438077714;6.0646031549658055;13.538429085723;77.21776145407634;fhuC;ABC-type transport system ATP-binding protein (probable substrate hydroxamate iron);COG1120;ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component;FepC;HELO_RS12775;HP;fhuC; ABC-type transport system ATP-binding protein (probable substrate hydroxamate iron);7.2.2.16;fhuC;ABC-type transport system ATP-binding protein (probable substrate hydroxamate iron);1.4520785996768817;-0.2080897599230136;-0.2950847166895638;-0.027794054686478553;-1.4798726543633602
HELO_3313;81.32894111393868;34.21521614985943;44.29521217474636;38.178823720464614;36.27554247971059;45.91307049636936;0.9823262100695415;1.7486302387965882;14.492333468126454;1.9691655337361724;1.8384799311869087;16.255832150269928;fhuD;ABC-type transport system periplasmic substrate-binding protein (probable substrate hydroxamate iron);COG0614;ABC-type Fe3+-hydroxamate transport system, periplasmic component;FepB;HELO_RS12780;P;fhuD; ABC-type transport system periplasmic substrate-binding protein (probable substrate hydroxamate iron);;fhuD;ABC-type transport system periplasmic substrate-binding protein (probable substrate hydroxamate iron);1.2252007327976848;-0.05063136781834121;-0.3317605808780151;0.8114097413489345;-0.4137909914487503
HELO_3314;65.27940021090315;27.963937514174713;35.0156804577199;29.331955869460817;37.72780857631868;37.04501898584639;4.339937994055149;1.2210590693761494;7.846848889736286;2.771601068205941;0.9449064625700413;14.857717386516208;fhuB;ABC-type transport system permease protein (probable substrate hydroxamate iron);COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS12785;P;fhuB; ABC-type transport system permease protein (probable substrate hydroxamate iron);;fhuB;ABC-type transport system permease protein (probable substrate hydroxamate iron);1.1943028035743248;-0.07908242045631297;0.025662286000623702;0.8008529647073308;-0.39344983886699403
HELO_3315;32.32154611209607;17.33784679384708;30.104353806040177;28.309065149191156;27.095746544832817;30.92579439934651;1.0435752535862075;0.651287254781282;7.060328402228393;1.7107625791503114;0.49606515316719685;10.676354039778827;bisC;biotin sulfoxide reductase;COG0243;Anaerobic selenocysteine-containing dehydrogenase;BisC;HELO_RS12790;C;bisC; biotin sulfoxide reductase;1.-.-.-;bisC;biotin sulfoxide reductase;0.8616310934758671;-0.03760598396641868;-0.18437078317847355;0.061732824480883686;-0.7998982689949834
HELO_3316;54.05725603388876;18.54013549570937;45.55237147054456;22.19659304719487;34.022607419745974;82.59015779449645;2.852981307983623;1.1524726625897017;30.482813170211273;2.921673337702067;4.313484351950556;97.61565345356126;HELO_3316;TonB-dependent receptor;COG4773;Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid;FhuE;HELO_RS12795;P;;bisC;;HELO_3316;TonB-dependent receptor;1.4944922387839048;-0.8444784207927301;-1.2550465883436575;-0.6024003741104575;-2.0968926128943624
HELO_3317;52.25818214560969;22.610385873403782;45.30368566342338;39.01397781777189;29.182232056378037;42.11754289347207;4.831897295967912;0.9208622733650074;8.407700726935127;9.370177496335375;0.3610873595699217;5.4214961863859;HELO_3317;DUF1007 family protein;COG3683;ABC-type uncharacterized transport system, periplasmic component;;HELO_RS12800;R;;;;HELO_3317;DUF1007 family protein;1.173581565806396;0.10285206648439082;-0.514575465723766;0.30472821940151107;-0.8688533464048849
HELO_3318;69.53220906371317;20.02888879251691;41.09881500867461;39.126997908038994;40.68868146392211;44.60205706474289;5.505293071722532;1.5064957107569488;4.946259455798882;3.4052009283137132;0.8671644308105274;3.651356799056021;HELO_3318;RcnA family protein;COG2215;ABC-type nickel/cobalt efflux system, permease component RcnA;RcnA;HELO_RS12805;P;;;;HELO_3318;RcnA family protein;1.7459096082594963;-0.11531927934465269;-0.12944316135198708;0.6291833210870461;-1.1167262871724501
HELO_3319;25.200482663344147;9.331045588018808;22.34702305940696;17.471011403888;22.30177535455137;22.697011646290054;1.0213033101268596;0.44304308738734044;2.1998412277850288;0.9292496689756523;1.169721171110806;3.7317768692219087;HELO_3319;YcsG family protein;COG1914;Mn2+ or Fe2+ transporter, NRAMP family;MntH;HELO_RS12810;P;;;;HELO_3319;YcsG family protein;1.3426071148595993;-0.02146653099056639;-0.02426525945081881;0.14488825225279278;-1.1977188626068065
HELO_3320;22.385191413784483;19.02245069142121;21.003666633488276;18.187640025564274;19.55587858201697;20.607254707032126;0.5161159986930456;1.4219835609371008;1.637119920169181;2.081744760625085;2.5257563807339167;1.0788945986896918;HELO_3320;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS12815;G;;;;HELO_3320;major facilitator superfamily transport protein;0.2239766708536246;0.026228167369954924;-0.07196474766915895;0.11407945429092425;-0.10989721656270035
HELO_3321;17.041143621323492;17.94337623385496;12.689892551134216;13.998919359837224;12.325943330776619;14.156550160766088;1.3634811197716719;2.122628963965727;0.19923947786579757;0.7166947565711214;0.6161140670560458;2.99554512489112;HELO_3321;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS12820;K;;;;HELO_3321;TetR family transcription regulator;-0.07040268851274689;-0.14683029039149975;-0.1857037500443841;0.2513493797440267;0.3217520682567736
HELO_3322;98.04351519451565;32.84860163789841;49.38665116891476;40.11629099044021;75.67926445433658;50.863235428138175;8.556131102810333;3.2093887409230435;7.056856079936605;3.432721165744895;2.580388962352625;6.696816810658427;HELO_3322;DUF1486 family protein;COG4922;Predicted SnoaL-like aldol condensation-catalyzing enzyme;;HELO_RS12825;R;;;;HELO_3322;DUF1486 family protein;1.5489662847051973;-0.04167063572752916;0.5641242881584976;0.9333503088843038;-0.6156159758208934
HELO_3323;75.6892428440637;18.241879574466093;62.2715282493524;50.53564394447877;101.40316022250356;65.15102797164475;4.2103271878656985;1.3952362701035481;8.051774470301458;2.3387892169940017;3.6652472611985334;5.873106163176896;HELO_3323;YwnB family protein;COG2910;Putative NADH-flavin reductase;YwnB;HELO_RS12830;R;;;;HELO_3323;YwnB family protein;1.994774495399672;-0.06420713294915892;0.6304247575155912;0.21326065009232575;-1.7815138453073462
HELO_3324;37.604754959855704;14.52120396598194;55.521030883531445;56.02643534417425;61.572756504193684;53.61607440060277;1.754758935761592;0.49468211316013316;3.945198563820015;3.5974039963065514;9.18519269923951;9.230137698651225;HELO_3324;HxlR family transcription regulator;COG1733;DNA-binding transcriptional regulator, HxlR family;HxlR;HELO_RS12835;K;;;;HELO_3324;HxlR family transcription regulator;1.3145380852051014;0.04946215683641508;0.19620903787211752;-0.5005470666582168;-1.8150851518633182
HELO_3325;42.03427666424796;53.004868099092896;24.683725406658528;26.444012400000407;22.158356777806734;23.70353080738215;0.8865931709120634;1.6774948163988994;0.16289524906376343;0.30764717947840137;1.718061711067129;3.6064307383545953;yojI;ABC-type transport system ATP-binding/permease protein (probable substrate microcin);COG4615;ABC-type siderophore export system, fused ATPase and permease components;PvdE;HELO_RS12840;P;yojI; ABC-type transport system ATP-binding/permease protein (probable substrate microcin);;yojI;ABC-type transport system ATP-binding/permease protein (probable substrate microcin);-0.3276032406584557;0.05613722259709064;-0.09318436773737293;0.8007689627272709;1.1283722033857266
HELO_3326;78.8633402579277;66.05517726455759;135.74518939900256;50.56792980241975;123.63672316258449;287.62845033698545;7.149486185472515;2.73938939396871;88.41973483430587;13.85749120982593;16.63157187010371;359.02868585560407;HELO_3326;TonB-dependent receptor;COG1629;Outer membrane receptor protein, Fe transport;CirA;HELO_RS12845;P;;yojI;;HELO_3326;TonB-dependent receptor;0.25218468797711413;-1.0777234335425305;-1.2114843054800897;-1.8536081958504678;-2.105792883827582
HELO_3327;39.96228853246259;18.55919431958739;18.79713800526552;17.45732981451384;15.937999539606531;20.09749257260518;2.4277365450013937;1.4631212829935047;4.7144231082669075;2.735798663775094;1.464358288908195;10.08313161547462;HELO_3327;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS12850;G;;;;HELO_3327;major facilitator superfamily transport protein;1.066449375722315;-0.09177966486622413;-0.31680805006416524;0.9572247744123459;-0.10922460130996914
HELO_3328;22.930639066491892;9.980177322841392;9.878273831485167;8.605273326041733;7.627829169886908;9.870230627088533;1.6661788462592102;0.11871315683080015;3.2513044803258304;0.3227001921242408;1.1128944916960897;5.010062787958881;HELO_3328;ABC-type transport system periplasmic substrate-binding protein;COG4594;ABC-type Fe3+-citrate transport system, periplasmic component;FecB;HELO_RS12855;P;;;;HELO_3328;ABC-type transport system periplasmic substrate-binding protein;1.1239575713546297;0.0010670978914446572;-0.3333130327921423;1.1384763750127385;0.014518803658108759
HELO_3329;29.076710551726652;13.608103593943161;15.658649358213196;14.195508112619423;13.534481847896673;13.543619172393937;2.092086522854246;0.49880521550146933;4.202348990952927;1.4332066554275553;1.6039840419838198;5.521022034234977;HELO_3329;ABC-type transport system permease protein;COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS12860;P;;;;HELO_3329;ABC-type transport system permease protein;1.0418778886803257;0.19588510744726584;-0.0009066873496230698;1.0482604622020357;0.006382573521710011
HELO_3330;20.691217863204866;11.46622905266875;11.381291892348122;11.183284857195497;11.801000166002373;11.330335724625883;1.2042583716440487;0.5960680008214235;2.9064981704730144;1.9445333507145541;0.34486546811461366;4.914845538651085;HELO_3330;ABC-type transport system permease protein;COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS12865;P;;;;HELO_3330;ABC-type transport system permease protein;0.7990859300750186;0.005949775207757302;0.054044453778860024;0.8148989747448763;0.015813044669857668
HELO_3331;7.732928441741834;4.27166279880743;7.3802129537866366;5.674968958678768;8.301842216988987;7.495055976232199;1.0609834649634493;0.25274373815885753;1.5909308398435205;0.7924736044527699;3.109936836489589;4.018691056531721;HELO_3331;dimethylmenaquinone methyltransferase domain protein;COG0684;RNA degradosome component RraA (regulator of RNase E activity);RraA;HELO_RS12870;J;;;;HELO_3331;dimethylmenaquinone methyltransferase domain protein;0.7282074271754215;-0.019636548314104108;0.13089301452550473;0.03984206493049314;-0.6883653622449284
HELO_3332;18.14650087847682;5.82770056612856;11.975463520044215;7.735539424409015;9.667317503147027;25.685364855473967;1.5968217751544584;0.1758428000936032;5.536845689099356;0.3524067550735064;1.3651812589408066;29.51243123609736;HELO_3332;IucA domain protein;COG4264;Siderophore synthetase component IucA/IucC/SbnC;IucA;HELO_RS12875;P;;;6.3.2.56;HELO_3332;IucA domain protein;1.4876090618953253;-1.0402626600719995;-1.3228513076281496;-0.4789679803993483;-1.9665770422946736
HELO_3333;19.000564709270666;5.6040213564493655;9.253443486170056;4.107194066840894;5.898612211383624;17.310829695439246;1.069091334971777;0.9201475722477981;5.678636140527834;0.7624919854439794;0.2987912086127773;20.75196456070937;HELO_3333;HpcH/GarL family aldolase;COG3836;2-keto-3-deoxy-L-rhamnonate aldolase RhmA;HpcH;HELO_RS12880;G;;;;HELO_3333;HpcH/GarL family aldolase;1.5986240437498043;-0.8365886620820602;-1.4083190933115164;0.12734357095828397;-1.4712804727915203
HELO_3334;12.960015189052925;3.3904975723712454;8.382887661419057;3.6480098798383676;5.138059005477963;16.66766835202403;1.3035055701860383;0.3061303433401713;4.423605651718745;0.09164905809282045;0.20778099864290908;19.165115681826055;HELO_3334;IucA domain protein;COG4264;Siderophore synthetase component IucA/IucC/SbnC;IucA;HELO_RS12885;P;;;6.3.2.55;HELO_3334;IucA domain protein;1.6688441573838362;-0.913007758706815;-1.525257236563283;-0.3398111449907302;-2.0086553023745664
HELO_3335;15.72329686779099;3.7433620055153867;6.131285982424383;3.508332786377831;4.799852738703829;14.690890423047348;0.8287924461511974;0.47917594216068604;3.5963880293751083;0.25995620599194186;0.5333436904101748;16.803721502944768;HELO_3335;probable decarboxylase (homolog to diaminopimelate decarboxylase);COG0019;Diaminopimelate decarboxylase;LysA;HELO_RS12890;E;;;4.1.1.20;HELO_3335;probable decarboxylase (homolog to diaminopimelate decarboxylase);1.8178774097312425;-1.1376930583981726;-1.4358390493202124;0.09193206719797686;-1.7259453425332656
HELO_3336;15.932474192431973;3.3562155652548253;8.485015539151945;3.7921273313243984;5.0224927766508705;16.351037598214447;1.4881897712842305;0.4134774287248814;5.573890342317226;0.6842473194239193;0.5357051024787384;20.280198616925958;HELO_3336;uncharacterized protein;COG4264;Siderophore synthetase component IucA/IucC/SbnC;IucA;HELO_RS12895;P;;;;HELO_3336;uncharacterized protein;1.9586455448692246;-0.8712998967634307;-1.5265892758435098;-0.03522914217850648;-1.993874687047731
HELO_3337;98.9585334924338;78.7017239964951;76.63101154834892;63.752955614345986;63.191907514322764;85.80537255729136;1.918445329022032;4.337767380417563;20.496372083757425;1.4073524549470595;5.818970779178222;44.792242371212545;HELO_3337;ABC-type transport system ATP-binding protein;COG1120;ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component;FepC;HELO_RS12900;HP;;;7.2.2.-;HELO_3337;ABC-type transport system ATP-binding protein;0.3267188046515823;-0.16115125040238443;-0.43539290422612;0.2035453988703404;-0.12317340578124192
HELO_3338;73.52775981743103;49.93907832819522;52.208799842725874;48.62894895166017;48.89622928738131;59.50236039722773;1.1047205633664328;2.2397093663279275;18.829053907139546;3.3262214806994805;1.3381033961334903;30.43133503172035;HELO_3338;ferredoxin domain protein;COG4759;Uncharacterized conserved protein, contains thioredoxin-like domain;;HELO_RS12905;R;;;;HELO_3338;ferredoxin domain protein;0.549005038970523;-0.18532656477927745;-0.2780606341514993;0.30078646746638693;-0.24821857150413607
HELO_3339;71.6498303924127;41.911315283217384;72.67863494459897;66.30960821353855;72.27835457107454;72.42545819579071;2.6765304807146633;3.3788027562785703;3.935855070150043;3.2054734636910194;4.580042074180242;4.019417313701063;HELO_3339;ABC-type transport system permease protein;COG1108;ABC-type Mn2+/Zn2+ transport system, permease component;ZnuB;HELO_RS12910;P;;;;HELO_3339;ABC-type transport system permease protein;0.759601307665001;0.004965969237405332;-0.0028932546060014275;-0.015320933646304269;-0.7749222413113053
HELO_3340;87.04999441261886;42.10320381293858;48.624767448111356;41.47443018607814;47.96030367956513;48.526158157447405;4.751757824977075;1.0870137614255742;2.480467151803579;4.1978402449986065;1.5721528264421005;4.470136965975575;HELO_3340;ABC-type transport system permease protein;COG1108;ABC-type Mn2+/Zn2+ transport system, permease component;ZnuB;HELO_RS12915;P;;;;HELO_3340;ABC-type transport system permease protein;1.0305278052985756;0.0028696289149490184;-0.01657820611916172;0.8301321999173421;-0.20039560538123347
HELO_3341;128.2538117661746;70.42752815705536;87.739883616894;72.59225828423797;79.18292691964506;90.27577319110003;3.5222054708167625;1.4378962157988076;2.005119419606828;3.3976948741990514;5.144100306680917;2.539315898292193;HELO_3341;ABC-type transport system ATP-binding protein;COG1121;ABC-type Mn2+/Zn2+ transport system, ATPase component;ZnuC;HELO_RS12920;P;;;7.2.2.5;HELO_3341;ABC-type transport system ATP-binding protein;0.8556547260808989;-0.040649323634517565;-0.18693690349948877;0.5019029372399597;-0.35375178884093916
HELO_3342;151.28687835183575;67.07385519265638;149.13288581972188;118.86650903686689;130.4938410584879;159.66786436714807;6.191892339240947;1.5137601321229648;15.76603698373085;8.733666807946234;7.581478174036781;7.380495559026995;HELO_3342;ABC-type transport system periplasmic substrate-binding protein;COG0803;ABC-type Zn uptake system ZnuABC, Zn-binding component ZnuA;ZnuA;HELO_RS12925;P;;;;HELO_3342;ABC-type transport system periplasmic substrate-binding protein;1.1616189182042245;-0.09784137401929804;-0.28908617257346947;-0.07728976157138767;-1.2389086797756121
HELO_3343;1085.5819413526065;95.68158516628756;1003.9198075691542;1133.6597009183463;588.879244677128;770.5559279372723;168.10553296396895;8.049057371827862;153.41358432538664;221.04622827240328;225.11774472917077;245.51610046905085;HELO_3343;PRC-barrel domain protein;;;;;;;;;HELO_3343;PRC-barrel domain protein;3.4904120376091265;0.38123773653824067;-0.3873510897228485;0.4939543325481317;-2.996457705060995
HELO_3344;38.05393243672344;13.952560598895177;13.276344673888767;16.059709151056747;16.175133147965596;15.790413445725695;2.8922710554748905;1.9517879511476475;3.813373574667362;0.2671645121356277;1.5238559818939836;6.0005279420765945;HELO_3344;ABC-type transport system ATP-binding protein;COG1120;ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component;FepC;HELO_RS12935;HP;;;7.2.2.-;HELO_3344;ABC-type transport system ATP-binding protein;1.3850752597110287;-0.23401111759698523;0.032683527877251706;1.2178300686878858;-0.16724519102314295
HELO_3345;32.249798873419095;13.707448722909794;11.40695263695693;13.441611171221032;13.486627575280254;13.042621420497815;1.8446013472137968;0.4342509225528249;1.4856339136014147;1.8483245750842794;1.8187010339869187;3.523624565514185;HELO_3345;ABC-type transport system permease protein;COG4779;ABC-type enterobactin transport system, permease component;FepG;HELO_RS12940;P;;;;HELO_3345;ABC-type transport system permease protein;1.1767986074950576;-0.17866346931221422;0.0449095034352589;1.2435333365079861;0.06673472901292854
HELO_3346;30.496750466254543;9.49991666960476;10.172094949032129;11.451946108950075;13.552966746772078;11.266119090884795;1.3394616184079717;1.7744465975670967;0.4256136081876366;0.5330715957498959;1.5162236534616813;3.1324791455590906;HELO_3346;ABC-type transport system permease protein;COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS12945;P;;;;HELO_3346;ABC-type transport system permease protein;1.5848251145125096;-0.1347791232719584;0.24663442565837235;1.360524129617926;-0.2243009848945836
HELO_3347;67.54511144218078;16.013477340032765;23.916387455744314;18.670186576552833;24.998039467479245;22.706278423777935;1.3893018405067272;1.2383904967860513;8.993980207301062;0.9867796853521716;1.9086818505082788;9.211281158598606;HELO_3347;ABC-type transport system periplasmic substrate-binding protein;COG0614;ABC-type Fe3+-hydroxamate transport system, periplasmic component;FepB;HELO_RS12950;P;;;;HELO_3347;ABC-type transport system periplasmic substrate-binding protein;2.0103757385404215;0.07182571565316032;0.133133636283695;1.5317845820280622;-0.4785911565123593
HELO_3348;57.42925545442714;13.499473722868046;30.040071068461902;26.492776879195755;25.94696029968215;33.04637573281092;2.9397810985884467;1.5056556251250541;9.972681200492605;0.34496065417178057;0.4972137568867781;17.997663693572758;HELO_3348;ABC-type transport system periplasmic substrate-binding protein;COG4607;ABC-type enterochelin transport system, periplasmic component;CeuA;HELO_RS12955;P;;;;HELO_3348;ABC-type transport system periplasmic substrate-binding protein;2.0106903688821722;-0.13336936954946843;-0.3373786885306167;0.779189675360489;-1.2315006935216832
HELO_3349;10.358165292821605;1.6836584181090861;3.560319459371858;1.8108540566210642;3.8264715062396415;5.735512857477716;0.5609178141395061;0.15641846606544432;1.4468929830530948;0.5232196032749571;0.37800610044398514;5.180277454210951;irgA;TonB-dependent receptor IrgA (probable substrate enterobactin);COG4771;Outer membrane receptor for ferrienterochelin and colicins;FepA;HELO_RS12960;P;irgA; TonB-dependent receptor IrgA (probable substrate enterobactin);;irgA;TonB-dependent receptor IrgA (probable substrate enterobactin);2.0814568532764075;-0.5626529084335727;-0.48081893821699984;0.7538701071351115;-1.327586746141296
HELO_3350;142.44156460329768;47.66853462501968;57.01633817787748;50.36207616306165;55.80169915167493;70.38642738789497;11.203114394401432;3.8685707150065394;19.806596231785274;4.322408101314966;8.426359531628547;38.605064565103284;irgB;LysR family transcription regulator IrgB;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS12965;K;irgB; LysR family transcription regulator IrgB;;irgB;LysR family transcription regulator IrgB;1.5594018878851728;-0.2991905628197262;-0.3297157157339621;1.006741422109112;-0.5526604657760608
HELO_3351;44.2481632424473;41.73540093301453;33.09621661283163;32.54502842726702;42.89415533126209;42.53683638270585;2.330775382322806;18.711905712349825;8.112359538898762;9.154544747394256;16.9509376056846;10.994778334209059;HELO_3351;DUF1656 domain protein;;;;;;;;;HELO_3351;DUF1656 domain protein;0.08242757264467926;-0.35262491378063565;0.011792274914840029;0.05562265263462418;-0.026804920010055078
HELO_3352;121.17984691405941;107.85850492818521;69.9568168393281;75.88839783419114;88.39730653445304;74.66881890423305;1.6093956458238803;2.765568265974139;1.5737508451082778;1.1359871888534627;3.3068089658057382;3.4106601119372457;HELO_3352;RND family transport protein MFP component;COG1566;Multidrug resistance efflux pump EmrA;EmrA;HELO_RS12975;V;;;;HELO_3352;RND family transport protein MFP component;0.166552210681588;-0.09275763561683181;0.24053243823901127;0.6912355061482804;0.5246832954666925
HELO_3353;71.19821091420528;61.82852858771067;55.01282038959633;65.86304918588559;64.39080336949489;53.643456261634846;3.2843057970979426;0.8800061394246248;1.4024143763343324;1.8639573276132282;0.7754567706249518;5.938135865748388;HELO_3353;AaeB domain protein;COG1289;Uncharacterized membrane protein YccC;YccC;HELO_RS12980;S;;;;HELO_3353;AaeB domain protein;0.20054329399680704;0.03570833488140046;0.2590390092217927;0.4019143486505774;0.20137105465377036
HELO_3354;38.70943153998657;32.36119490611785;21.829183654739314;36.181522566017605;31.297427048003982;22.985789201335134;1.5395164509863994;2.935106261427627;0.9997361484459754;2.6551298980239015;0.6794489331258896;2.965044297967653;HELO_3354;AEC family transport protein;COG0679;Predicted permease, AEC (auxin efflux carrier) family;YfdV;HELO_RS12985;R;;;;HELO_3354;AEC family transport protein;0.2513107450513239;-0.07130063775429818;0.4292393290732637;0.727301798992599;0.47599105394127506
HELO_3355;90.53938043865287;18.128171719890847;27.941340906284733;41.2330506774853;33.29181374933906;26.579748833252243;5.284583115414619;0.6908454952333312;3.3454134022444384;3.0637264187305946;4.414288699780866;4.000832599947834;yliI;aldose sugar dehydrogenase YliI;COG2133;Glucose/arabinose dehydrogenase, beta-propeller fold;YliI;HELO_RS12990;G;yliI; aldose sugar dehydrogenase YliI;1.1.5.-;yliI;aldose sugar dehydrogenase YliI;2.2586935406835718;0.06952244777537864;0.31425489436536314;1.730783209058024;-0.5279103316255478
HELO_3356;198.50715122363113;393.7594246103756;333.5874587305348;286.09863320731705;393.31585971023304;353.7916118826115;8.079261948863277;17.718383367269283;38.96296177501086;20.273496230288373;39.396764521796015;27.829458157224074;gbtA;ABC-type transport system ATP-binding protein (probable substrate glycine betaine);COG4175;ABC-type proline/glycine betaine transport system, ATPase component;ProV;HELO_RS12995;E;gbtA; ABC-type transport system ATP-binding protein (probable substrate glycine betaine);7.6.2.9;gbtA;ABC-type transport system ATP-binding protein (probable substrate glycine betaine);-0.9845332498695196;-0.08458853113770459;0.1523798367005611;-0.830531441319458;0.15400180855006163
HELO_3357;201.12997341092284;437.5024259226866;343.01451569856;316.7116093634929;445.04607758541925;372.3771364573167;4.083033398336742;22.137814515289417;48.29065018703735;42.677633832655836;39.2575526909381;22.40580306940154;gbtB;ABC-type transport system permease protein (probable substrate glycine betaine);COG4176;ABC-type proline/glycine betaine transport system, permease component;ProW;HELO_RS13000;E;gbtB; ABC-type transport system permease protein (probable substrate glycine betaine);;gbtB;ABC-type transport system permease protein (probable substrate glycine betaine);-1.117301552431739;-0.11816414688056298;0.2565591639238409;-0.8853503159669547;0.23195123646478422
HELO_3358;429.1347974987637;966.8463490563512;1236.4522588873494;752.3596300682785;1624.8346528490254;1308.0135275161244;26.383971279949822;35.95569661462627;95.30646572192036;61.23601799856435;197.40101508816926;115.99015957797847;betH;BCC family transport protein BetH (substrate glycine-betaine);COG1292;Choline-glycine betaine transporter;BetT;HELO_RS13005;M;betH; BCC family transport protein BetH (substrate glycine-betaine);;betH;BCC family transport protein BetH (substrate glycine-betaine);-1.1699891812173107;-0.08110713950567394;0.31270053663605424;-1.605619252576167;-0.43563007135885634
HELO_3359;506.54116971171317;478.5968157209839;564.9328599488797;484.57435705495647;540.6784334181948;600.6433773656922;13.398196176581209;5.313515782641684;29.638730230328395;23.785974357767135;5.517286064877673;33.02124279985953;purA;adenylosuccinate synthetase;COG0104;Adenylosuccinate synthase;PurA;HELO_RS13010;F;purA; adenylosuccinate synthetase;6.3.4.4;purA;adenylosuccinate synthetase;0.08170277267919168;-0.08827767885056836;-0.15147193441954165;-0.24538373368625344;-0.3270865063654451
HELO_3360;637.61397443848;674.0874879434564;779.1781443578803;779.863022371067;680.8974233865946;773.4061437196125;14.01645429934348;20.583652313861236;35.08712828766283;23.49660121791885;27.666009103430422;13.2985807372525;hisZ;ATP phosphoribosyltransferase regulatory subunit;COG3705;ATP phosphoribosyltransferase regulatory subunit HisZ;HisZ;HELO_RS13015;E;hisZ; ATP phosphoribosyltransferase regulatory subunit;;hisZ;ATP phosphoribosyltransferase regulatory subunit;-0.08013035734572149;0.010713185545750292;-0.18353566469166083;-0.27814627526449875;-0.19801591791877726
HELO_3361;734.5669454840796;477.68686817742554;617.7533623388446;594.452917866103;662.0359803077313;616.4812832305337;28.716023370713042;15.413245520855313;44.61675678413924;25.15401160625464;70.13416505460691;43.85405582306557;hflC;modulator of FtsH protease HflC;COG0330;Regulator of protease activity HflC, stomatin/prohibitin superfamily;HflC;HELO_RS13020;O;hflC; modulator of FtsH protease HflC;;hflC;modulator of FtsH protease HflC;0.6197744210143092;0.0029690526397825323;0.10269175460211599;0.2524612430014521;-0.3673131780128571
HELO_3362;849.6462510331213;601.4082784591301;710.6850912401915;698.011465539419;740.7757361656548;809.5303589219429;9.878067955890769;24.759242905182163;35.00968111484046;59.19963950349147;38.603130911701236;20.09729501953419;hflK;modulator of FtsH protease HflK;COG0330;Regulator of protease activity HflC, stomatin/prohibitin superfamily;HflC;HELO_RS13025;O;hflK; modulator of FtsH protease HflK;;hflK;modulator of FtsH protease HflK;0.49781770273857084;-0.18762720986345904;-0.12788314642345533;0.0696930749933653;-0.42812462774520554
HELO_3363;1134.0884660122783;921.168929622705;996.5344266169519;1054.4280542943782;800.1381870636156;985.0955391833662;79.23212211076533;65.92478646112606;67.0981244269498;23.717309600500002;34.30300708126512;10.64032935449791;hflX;GTPase HflX;COG2262;50S ribosomal subunit-associated GTPase HflX;HflX;HELO_RS13030;J;hflX; GTPase HflX;;hflX;GTPase HflX;0.29970177864788816;0.016639201253479285;-0.2996763185181539;0.2030054060892148;-0.09669637255867336
HELO_3364;2993.4021427790085;1870.2012768220566;1885.233276562704;1643.623613528666;1442.2958056543646;2020.8317390626069;213.4798008608585;280.70519536644235;303.1692817910768;134.86065223136384;305.53598722891286;312.5933800507712;hfq;RNA-binding protein Hfq;COG1923;sRNA-binding regulator protein Hfq;Hfq;HELO_RS13035;T;hfq; RNA-binding protein Hfq;;hfq;RNA-binding protein Hfq;0.678303234503808;-0.1001548284264473;-0.4862959255694328;0.566605047506453;-0.11169818699735501
HELO_3365;265.87255432699516;154.51049677130348;193.14791331532265;230.56952266911094;181.36523438046004;194.0035371756385;19.915530493949298;0.7900629650958721;15.49325944387694;4.102820161426746;9.143050114624717;10.548335989771575;miaA;tRNA dimethylallyltransferase;COG0324;tRNA A37 N6-isopentenylltransferase MiaA;MiaA;HELO_RS13040;J;miaA; tRNA dimethylallyltransferase;2.5.1.75;miaA;tRNA dimethylallyltransferase;0.7791389798294279;-0.006344091935050145;-0.09666956910668567;0.45265065034478713;-0.3264883294846408
HELO_3366;341.0865540188045;270.8039448889026;238.63755525083852;267.84133206366704;208.90090398738084;214.57030114233712;5.727218867654904;18.178497254766064;3.6824057599962514;21.772121430277775;10.801047784871358;8.87112749513163;mutL;DNA mismatch repair protein MutL;COG0323;DNA mismatch repair ATPase MutL;MutL;HELO_RS13045;L;mutL; DNA mismatch repair protein MutL;;mutL;DNA mismatch repair protein MutL;0.33179500381370985;0.1526955870726816;-0.03845005349562847;0.6662029655133743;0.33440796169966447
HELO_3367;162.984304590606;117.95852633414601;105.10699593747056;110.95841710697384;90.4852090417873;95.71884279224669;9.882609951114489;1.97839811064893;6.434776486434626;13.041450433862957;4.197042635564055;4.430346188501148;amiC;N-acetylmuramoyl-L-alanine amidase AmiC;COG1388;LysM repeat;LysM;HELO_RS13050;M;amiC; N-acetylmuramoyl-L-alanine amidase AmiC;3.5.1.28;amiC;N-acetylmuramoyl-L-alanine amidase AmiC;0.4630990565447952;0.13365089194353263;-0.08025847018268095;0.7616888485077604;0.2985897919629652
HELO_3368;154.77913021822894;127.0285763884574;218.59857220745593;262.48019777491805;231.71327505010512;200.34887616551427;2.063264378580158;3.265006912190957;7.695869738115264;16.596778527770525;11.162231348075347;8.880246950288791;nnr;bifunctional NAD(P)H-hydrate repair enzyme Nnr;COG0063;NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain;Nnr2;HELO_RS13060;F;nnr; bifunctional NAD(P)H-hydrate repair enzyme Nnr;4.2.1.136,5.1.99.6;nnr;bifunctional NAD(P)H-hydrate repair enzyme Nnr;0.2830361076883321;0.1251712543532868;0.20885609127889015;-0.3701954518508712;-0.6532315595392033
HELO_3369;55.512078695445545;61.52758041687506;70.75159314580418;82.76016466073033;73.72916032514209;72.57447846706422;1.9034313846543507;2.070995347483196;6.641307626647413;2.5523551992581712;5.247264849727429;4.954819935041096;queG;epoxyqueuosine reductase;COG1600;Epoxyqueuosine reductase QueG (queuosine biosynthesis);QueG;HELO_RS13065;J;queG; epoxyqueuosine reductase;1.17.99.6;queG;epoxyqueuosine reductase;-0.1459334343217078;-0.036194545442905124;0.022465901268444277;-0.380646153539395;-0.23471271921768722
HELO_3370;328.78395206176924;305.9563286526521;424.15306495232363;427.02404765121196;348.86472922309895;428.54689081281384;0.40080718622693406;1.3311890062226086;29.469851373748014;13.899409109427161;29.37627646901379;18.41083287538113;serS;serine--tRNA ligase;COG0172;Seryl-tRNA synthetase;SerS;HELO_RS13070;J;serS; serine--tRNA ligase;6.1.1.11;serS;serine--tRNA ligase;0.1034877812738717;-0.014833291095309065;-0.2960183994481369;-0.38129443340810454;-0.48478221468197624
HELO_3371;27.785856684603484;75.03219903140854;34.067637897808034;27.23750056981203;22.84625803403124;34.86491798733788;1.5220991635112877;1.729889930208749;2.1909791522566078;1.9295704037235513;0.8040460102504154;4.508835557071758;HELO_3371;NHE family transport protein;COG0569;Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain;TrkA;HELO_RS13075;TP;;serS;;HELO_3371;NHE family transport protein;-1.4012503694602518;-0.03243307560664288;-0.5888104361389352;-0.31721318337420357;1.0840371860860483
HELO_3372;317.61221792438806;207.70506104655365;317.89429414669706;373.45844529537453;341.974042929073;325.5711642791387;14.741354853366941;19.217606633027895;9.034113847576464;8.784498856631139;1.9507713731305276;22.57113812134063;trpC;indole-3-glycerol-phosphate synthase;COG0134;Indole-3-glycerol phosphate synthase;TrpC;HELO_RS13080;E;trpC; indole-3-glycerol-phosphate synthase;4.1.1.48;trpC;indole-3-glycerol-phosphate synthase;0.610336005488171;-0.034319124585227456;0.07070198520604265;-0.03559581740617901;-0.64593182289435
HELO_3373;248.8469932814072;184.62449005713128;222.4478494851643;262.0255391599812;230.644444083577;217.68111910466214;12.920283355025486;14.685668193737241;8.162606687173293;8.771351237135281;15.251650512176463;22.327888373118846;trpD;anthranilate phosphoribosyltransferase;COG0547;Anthranilate phosphoribosyltransferase, glycosyltransferase domain;TrpD;HELO_RS13085;E;trpD; anthranilate phosphoribosyltransferase;2.4.2.18;trpD;anthranilate phosphoribosyltransferase;0.4286577938566092;0.03110949627467985;0.0830834165287131;0.1922161927528867;-0.23644160110372248
HELO_3374;208.9410527494335;123.22961281629766;221.43117844512233;234.38388883508347;214.51926627387056;225.58884072776675;5.947430141826756;5.886093818985607;22.268101169945563;4.514216799276374;6.964769533765729;3.472761501540774;trpG;anthranilate synthase component II;COG0512;Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase);PabA;HELO_RS13090;EH;trpG; anthranilate synthase component II;4.1.3.27;trpG;anthranilate synthase component II;0.7569751926914616;-0.026717785099621416;-0.07225996730237139;-0.11009250680584248;-0.8670676994973041
HELO_3375;343.49454467105943;198.20580512689392;316.9052892682153;282.9160865470304;273.177484379938;310.4409053096994;7.54312046093849;5.487291272743344;33.120551032886745;27.226032960859126;35.37335063700769;29.229632953074745;trpE;anthranilate synthase component I;COG0147;Anthranilate/para-aminobenzoate synthases component I;TrpE;HELO_RS13095;EH;trpE; anthranilate synthase component I;4.1.3.27;trpE;anthranilate synthase component I;0.7902214468492028;0.02963857656282265;-0.1838483424950894;0.14552269346337532;-0.6446987533858275
HELO_3376;73.82865151255328;31.17562021264813;96.56679520677557;103.25670137408201;110.13508390850076;100.01174497024495;2.8150678237606015;1.1579780362076364;2.5517554382164054;3.221483088159641;13.929038810740945;4.555168380689997;gph;phosphoglycolate phosphatase;COG0546;Phosphoglycolate phosphatase, HAD superfamily;Gph;HELO_RS13100;C;gph; phosphoglycolate phosphatase;3.1.3.18;gph;phosphoglycolate phosphatase;1.2176228186397697;-0.05006090394599827;0.13779127913193;-0.4328603680127552;-1.650483186652525
HELO_3377;111.04076195004541;75.04075504854096;161.81849826995088;194.07397639365698;321.9005399820516;166.6744546140604;4.505465884374385;1.6756343024539384;2.0133582002452424;14.169323495820048;15.908598325218824;8.762783772165559;ndh;NADH dehydrogenase;COG1252;NADH dehydrogenase, FAD-containing subunit;Ndh;HELO_RS13105;C;ndh; NADH dehydrogenase;7.1.1.2;ndh;NADH dehydrogenase;0.5591789373769398;-0.04239829190283029;0.9454269440711123;-0.5816392096585812;-1.140818147035521
HELO_3378;569.9627353446759;204.7164383237421;437.90957826402814;528.9391377274709;504.3599115400073;428.3578604989245;11.623123891141258;2.8795462995423864;8.422423053548014;9.814621537649495;21.853334356746267;16.884962182030133;mscS1;mechanosensitive ion channel MscS;COG0668;Small-conductance mechanosensitive channel;MscS;HELO_RS13110;M;mscS1; mechanosensitive ion channel MscS;;mscS1;mechanosensitive ion channel MscS;1.4727395083315127;0.031743150023084254;0.2351306205408612;0.4112159849615171;-1.0615235233699956
HELO_3379;188.71810521572215;188.0897130471093;74.09153492718652;64.83009894454386;66.24191554617785;65.8104392926707;6.121974539121766;9.947524159162628;10.70379850825449;7.921751828686578;6.684225402411799;3.5988872662567184;HELO_3379;UPF0213 family protein;COG2827;Predicted endonuclease, GIY-YIG superfamily;YhbQ;HELO_RS13115;L;;mscS1;;HELO_3379;UPF0213 family protein;0.00478648567042228;0.16857673691446884;0.00928727886420333;1.5057119148640954;1.500925429193673
HELO_3380;133.21319597475923;111.44394406515971;172.50662665501378;160.92024067917467;184.66590128595544;169.83624221120584;2.4166895176856165;4.1483781727303;1.7598014839812577;14.809827710402379;8.37931141940748;5.956383640377292;rpe;ribulose-5-phosphate 3-epimerase;COG0036;Pentose-5-phosphate-3-epimerase;Rpe;HELO_RS13120;G;rpe; ribulose-5-phosphate 3-epimerase;5.1.3.1;rpe;ribulose-5-phosphate 3-epimerase;0.25532056227074307;0.022376694722701096;0.12009481026582591;-0.34808754356835436;-0.6034081058390974
HELO_3381;120.70216206978053;35.20941539544598;356.0895485348312;387.0810767270429;303.83275410304435;316.31054286438393;7.4058202647091305;2.137520136965874;40.61772099208573;22.41649326978904;83.17262808459654;45.052143551931586;ggt;gamma-glutamyltranspeptidase;COG0405;Gamma-glutamyltranspeptidase;Ggt;HELO_RS13125;E;ggt; gamma-glutamyltranspeptidase;2.3.2.2,3.4.19.13;ggt;gamma-glutamyltranspeptidase;1.7489180084604863;0.17039045246148987;-0.0578775286947284;-1.3825406584794884;-3.1314586669399747
HELO_3382;290.6663782246298;419.84581900770627;232.62479584040065;151.40100901439726;156.81133112120045;243.4283274496512;31.831219623764035;3.499442445692765;37.68538279772924;7.166010441884294;17.424479474804805;26.233886576545054;cysP;ABC-type transport system periplasmic substrate-binding protein (probable substrate thiosulfate);COG4150;ABC-type sulfate transport system, periplasmic component;CysP;HELO_RS13130;P;cysP; ABC-type transport system periplasmic substrate-binding protein (probable substrate thiosulfate);;cysP;ABC-type transport system periplasmic substrate-binding protein (probable substrate thiosulfate);-0.5289726951343994;-0.06521808938396756;-0.6312106955943193;0.254907596863009;0.7838802919974084
HELO_3383;120.93448413301074;167.72376265856943;61.499677575783835;53.58474773126387;39.60727925675321;69.93736971278302;20.515148590414668;5.159602707850969;4.338541219445295;2.208192771500628;3.9863915003817083;13.002727231503789;cysT;ABC-type transport system permease protein (probable substrate sulfate/thiosulfate);COG0555;ABC-type sulfate transport system, permease component;CysU;HELO_RS13135;P;cysT; ABC-type transport system permease protein (probable substrate sulfate/thiosulfate);;cysT;ABC-type transport system permease protein (probable substrate sulfate/thiosulfate);-0.4685569833442953;-0.18269709036708726;-0.8048074696060192;0.7814884476945734;1.2500454310388687
HELO_3384;73.20429662287914;111.33647391285452;45.319178668651595;49.32489578584953;28.222736084727256;52.877460461505486;10.583237691123216;9.884134079577919;2.118072112987717;4.284334303487374;3.0542354184485188;10.646760843140964;cysW;ABC-type transport system permease protein (probable substrate sulfate/thiosulfate);COG4208;ABC-type sulfate transport system, permease component;CysW;HELO_RS13140;P;cysW; ABC-type transport system permease protein (probable substrate sulfate/thiosulfate);;cysW;ABC-type transport system permease protein (probable substrate sulfate/thiosulfate);-0.5982517943362078;-0.21807217862311834;-0.8825905882941107;0.4618208747625161;1.0600726690987239
HELO_3385;153.60047341972117;165.80115863682383;130.1232574664826;153.82482970781163;99.46384265138465;136.0683883207776;8.143286658403547;12.46082794895836;7.898445809896407;2.707106179117663;3.639441256228726;20.188944016908852;cysA;ABC-type transport system ATP-binding protein (probable substrate sulfate/thiosulfate);COG1118;ABC-type sulfate/molybdate transport systems, ATPase component;CysA;HELO_RS13145;P;cysA; ABC-type transport system ATP-binding protein (probable substrate sulfate/thiosulfate);7.3.2.3;cysA;ABC-type transport system ATP-binding protein (probable substrate sulfate/thiosulfate);-0.10958457297794322;-0.06397228441177027;-0.44821952200312687;0.1736488521451811;0.2832334251231243
HELO_3386;212.47925964068656;115.28994691616147;125.41030221326446;142.15594402215365;151.6477921606918;131.52490575457753;12.750594375727523;6.9713284445070505;7.265363563376447;6.383379950778775;4.01071417412742;6.803578653329253;HELO_3386;uncharacterized protein;COG3056;Uncharacterized lipoprotein YajG;YajG;HELO_RS13150;S;;cysA;;HELO_3386;uncharacterized protein;0.8763695296174605;-0.06814946926601628;0.20394320847125158;0.6878323984568411;-0.18853713116061943
HELO_3387;249.64256111421795;137.2380502500814;215.53626631792213;227.77132336183408;212.85527155715454;206.4620514446117;11.348125193223689;3.1359312297411037;7.667106226553253;10.399632691906453;18.90039160607767;14.723467847845711;tpm;thiopurine S-methyltransferase;;;;;;;;;tpm;thiopurine S-methyltransferase;0.8584766420697507;0.06176120762612847;0.0437873046338062;0.27278395101596065;-0.5856926910537901
HELO_3388;327.95643010964386;223.2353581761823;313.47915444321535;308.2284352904123;225.9652049880054;254.96687195340328;10.27551306987357;2.0394390426457982;32.86768911430506;56.94044945554995;23.397582797718982;5.66077776284698;HELO_3388;YgiM family protein;COG3103;Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family;YgiM;HELO_RS13160;R;;tpm;;HELO_3388;YgiM family protein;0.5528827283333291;0.29700728570237533;-0.1734859627291776;0.36193940923401247;-0.1909433190993166
HELO_3389;256.6026158761663;189.30790228395733;214.50913195355784;243.50194090887007;204.69356722694286;212.87449946602646;7.800218524744099;3.353131034726574;12.178708782242534;14.49301033367621;24.28736514500696;23.62622808773203;miaB;tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase;COG0621;tRNA A37 methylthiotransferase MiaB;MiaB;HELO_RS13165;J;miaB; tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase;2.8.4.3;miaB;tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase;0.43681177479667355;0.010984524809834362;-0.05626780201815773;0.26838276530004457;-0.16842900949662898
HELO_3390;309.9093837634363;289.25348457280785;464.4447372459553;446.60844045389035;467.507803105659;497.95313415673223;11.702395405302315;6.9087226223407106;63.00624006416258;27.79239486958727;33.33866148597252;38.99578451355842;ybeZ;PhoH family protein YbeZ;COG1702;Phosphate starvation-inducible protein PhoH, predicted ATPase;PhoH;HELO_RS13170;T;ybeZ; PhoH family protein YbeZ;;ybeZ;PhoH family protein YbeZ;0.09918077313210993;-0.10029442674648337;-0.09083123546176353;-0.6824101516882557;-0.7815909248203656
HELO_3391;157.74002414457263;113.45725466397857;136.90585213434704;125.86723455155725;172.16515329531273;157.8468341330019;4.655725045604277;4.39789966890495;7.31414536626724;21.99484232259486;9.927173168911978;15.493009345980006;ybeY;endoribonuclease YbeY;COG0319;ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme;YbeY;HELO_RS13175;J;ybeY; endoribonuclease YbeY;;ybeY;endoribonuclease YbeY;0.4718570216493747;-0.20395265701931997;0.124512303100623;-0.0009704069448579489;-0.47282742859423266
HELO_3392;208.56382613010678;132.52973246984286;171.708439390186;166.21483210214345;211.90365976721992;176.1890239953647;2.9011023009797996;4.648702343413195;8.647958910919082;17.814336973043904;8.046096737005547;9.444687781046909;corC;CorC family transport protein (probable substrate magnesium/cobalt);COG4535;Mg2+ and Co2+ transporter CorC, contains CBS pair and CorC-HlyC domains;CorC;HELO_RS13180;P;corC; CorC family transport protein (probable substrate magnesium/cobalt);;corC;CorC family transport protein (probable substrate magnesium/cobalt);0.650228691341197;-0.0369506568496476;0.2649115109469431;0.24210046882471303;-0.40812822251648395
HELO_3393;139.6985721824351;77.54647618877179;112.98238363350133;122.83819938858824;124.78298140884381;108.46238616887543;7.534773312911306;0.7286147527516782;1.7619904562650361;9.543851160672164;7.0141972459294815;8.663574286615372;lnt;apolipoprotein N-acyltransferase;COG0815;Apolipoprotein N-acyltransferase;Lnt;HELO_RS13185;M;lnt; apolipoprotein N-acyltransferase;2.3.1.269;lnt;apolipoprotein N-acyltransferase;0.8409892292813907;0.058375656887445615;0.20050152573068303;0.36217247680489617;-0.4788167524764946
HELO_3394;141.81199990588144;29.695187249465118;33.586965730004486;85.19363772249629;43.25387844845989;32.53083799301432;6.382239132781115;0.46895332786699573;0.3484497902113749;13.435255734513989;4.166978845658028;4.36951661202057;phbC;poly-beta-hydroxyalkanoate polymerase;COG3243;Poly-beta-hydroxybutyrate synthase;PhaC;HELO_RS13190;I;phbC; poly-beta-hydroxyalkanoate polymerase;2.3.1.-;phbC;poly-beta-hydroxyalkanoate polymerase;2.218032832365827;0.04473991448298609;0.4003153607869496;2.090556764087512;-0.12747606827831515
HELO_3395;212.33162728874413;68.34557278105841;74.32621091038497;168.32668007549665;69.87828097723882;56.65739750356553;8.093247772341098;6.122338051123095;11.066745714381256;12.901899586152936;8.655825456835064;6.067731880479651;HELO_3395;uncharacterized protein;;;;;;;;;HELO_3395;uncharacterized protein;1.6212221821522164;0.38564624111065626;0.29783789537999716;1.887520242865298;0.2662980607130816
HELO_3396;84.86954150198649;70.0620710203839;56.499676971040486;76.94478802797127;59.13439079518736;51.006461766098;3.9477330686249803;4.9237557204280265;6.63272206480269;4.818934918444701;6.002404051950186;1.504451830315344;HELO_3396;uncharacterized protein;;;;;;;;;HELO_3396;uncharacterized protein;0.27306675363473243;0.14486296289570433;0.2094994145117175;0.7234556003353898;0.4503888467006574
HELO_3397;138.57057502110624;134.8314917170956;138.59104547253614;156.0899051574418;146.1320421755531;143.72779270776405;5.204307528402374;3.0582208074477077;4.991936581792871;7.718300617170783;6.240990910666491;4.898902880617026;aroC;chorismate synthase;COG0082;Chorismate synthase;AroC;HELO_RS13205;E;aroC; chorismate synthase;4.2.3.5;aroC;chorismate synthase;0.03917681873555967;-0.05213559739063367;0.02376947309587507;-0.052347178185754295;-0.09152399692131397
HELO_3398;187.28744343043147;157.06386586348177;230.18798573762373;236.4428463790183;240.81582867339398;243.02698380828988;3.786394036406854;8.727461630320423;11.207441624892015;9.573433323500701;8.013632868421181;13.818536562489767;prmB;50S ribosomal protein L3 glutamine methyltransferase;COG2890;Methylase of polypeptide chain release factors;HemK;HELO_RS13210;J;prmB; 50S ribosomal protein L3 glutamine methyltransferase;2.1.1.298;prmB;50S ribosomal protein L3 glutamine methyltransferase;0.2524291937028966;-0.07797425918674783;-0.013132002743455828;-0.37410389343432815;-0.6265330871372248
HELO_3399;101.49331442874053;88.4776026700918;81.0153276133377;87.72459048357844;81.57460677333968;80.0403327294734;5.807710833353193;8.688836991099985;7.4588189792867325;1.498151527570671;12.351065490982869;7.7057766048398175;HELO_3399;Smr domain protein;COG2840;DNA-nicking endonuclease, Smr domain;SmrA;HELO_RS13215;L;;prmB;;HELO_3399;Smr domain protein;0.19593129815380195;0.01725345867375072;0.02705809683881988;0.33881780417874463;0.14288650602494268
HELO_3400;118.36705746804677;67.3486093504216;112.052428681025;135.53739930194092;166.28611651072242;104.69939275276538;7.260436510809859;2.419870780950204;5.900306067752263;3.121128724722797;9.883232086457895;3.514083900538771;rssA;NTE family protein RssA;COG1752;Predicted acylesterase/phospholipase RssA, containd patatin domain;RssA;HELO_RS13220;R;rssA; NTE family protein RssA;;rssA;NTE family protein RssA;0.8044208516896756;0.09702489712606521;0.6623506291048358;0.1754376528478847;-0.6289831988417909
HELO_3401;158.27683218113998;100.62644171886491;121.25350607481148;125.00866351338989;158.7753678417871;108.0089683378866;3.5400806512536316;6.009492450517707;4.625649485048567;8.619974589046656;9.525727409440206;9.34566493332339;HELO_3401;alpha/beta hydrolase fold protein;COG0596;2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold;MenH;HELO_RS13225;HR;;rssA;;HELO_3401;alpha/beta hydrolase fold protein;0.648260613866757;0.16542900776997715;0.5515981761620017;0.5470896003827095;-0.10117101348404756
HELO_3402;157.11696101659723;95.95714935349822;152.19926916558154;151.59373938626405;184.43507347685832;154.14591691285707;10.599431674374587;5.222865552583754;8.333189165382013;4.6219146895675625;3.792704250365994;14.21648308468347;HELO_3402;alpha/beta hydrolase fold protein;COG0596;2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold;MenH;HELO_RS13230;HR;;;;HELO_3402;alpha/beta hydrolase fold protein;0.7055729444313261;-0.01821631399095569;0.257288414427018;0.02736640324336026;-0.6782065411879659
HELO_3403;247.5941131192274;125.93548506601987;233.2430112360148;228.83989757577828;248.96553149951487;231.54704680684267;11.372310474354457;5.383529969054125;26.780142533493912;14.057573021813932;29.788669701761588;3.319140205883331;HELO_3403;GntR family transcription regulator;COG2186;DNA-binding transcriptional regulator, FadR family;FadR;HELO_RS13235;K;;;;HELO_3403;GntR family transcription regulator;0.9696966989614344;0.010483386248549387;0.10420655232563902;0.0962695140678127;-0.8734271848936217
HELO_3404;25.921651132443902;21.953428261757868;25.22687442668413;24.390166324057827;31.205056340262445;29.274655562648604;1.019756174233341;0.5467933609468537;1.1252468334318593;0.6865729662573611;2.5504937856846825;1.069987381256304;lhpD;delta-1-pyrroline-2-carboxylate reductase;COG2055;Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family;AllD;HELO_RS13240;C;lhpD; delta-1-pyrroline-2-carboxylate reductase;1.5.1.21;lhpD;delta-1-pyrroline-2-carboxylate reductase;0.23005724787794435;-0.2070646608877338;0.08917666945593616;-0.16934365172131294;-0.3994008995992573
HELO_3405;21.245429972134648;15.129866321567027;27.962440176896905;23.119599625213965;33.19890330394828;28.19291984026646;1.4571014224684984;0.1993618695678135;1.2808429439598497;1.1302609283732996;1.2605786375338168;0.9025539388536348;udh;uronate dehydrogenase;COG0451;Nucleoside-diphosphate-sugar epimerase;WcaG;HELO_RS13245;M;udh; uronate dehydrogenase;1.1.1.203;udh;uronate dehydrogenase;0.4637745019870563;-0.01143535550905117;0.22833154661459432;-0.3921095306554072;-0.8558840326424635
HELO_3406;9.052484626553612;7.456251893146532;12.139100737208446;9.54128149201467;17.31012096504017;14.487877007309033;1.0320434191892347;0.1355153935191551;1.2027913922164002;1.2644861374541967;1.7756008141635198;0.37411693306276295;HELO_3406;D-galactarolactone isomerase;COG3618;Predicted metal-dependent hydrolase, TIM-barrel fold;;HELO_RS13250;R;;udh;5.4.1.4;HELO_3406;D-galactarolactone isomerase;0.24946187261462827;-0.2372728625131435;0.24150192126348813;-0.6235872712066843;-0.8730491438213126
HELO_3407;8.282514342247309;5.402220384514789;9.069245121316735;7.076081979980855;10.607441605456884;9.706671574977726;0.47941543559875227;0.6573620800919631;1.747164323125228;0.9452004850813797;1.4395088580792696;0.7953065186696824;gci;D-galactarolactone cycloisomerase;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS13255;MR;gci; D-galactarolactone cycloisomerase;5.5.1.27;gci;D-galactarolactone cycloisomerase;0.5359432993355755;-0.08855452315572698;0.11653996951839529;-0.20592250923911948;-0.741865808574695
HELO_3408;2.494331690097795;3.5186940292099878;8.477641881390591;6.134370960437054;9.85597648032964;8.761393038667025;0.38733468814838035;0.5830547884860292;0.45913386914053417;0.22442849299627624;0.36815671138103906;1.423863745731294;HELO_3408;TRAP transporter large transmembrane protein (probable substrate D-glucuronate/D-galacturonate);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS13260;G;;gci;;HELO_3408;TRAP transporter large transmembrane protein (probable substrate D-glucuronate/D-galacturonate);-0.3708893135105864;-0.04255889918262268;0.15333054708399363;-1.4820704893250785;-1.111181175814492
HELO_3409;4.589926196822929;10.67508181219515;10.7368346417;8.653626306071715;15.63310259659629;15.075792562037355;0.7314118314875763;1.5358952015413463;2.241220506114398;1.3937972717998295;7.489317353920192;1.780796686570354;HELO_3409;TRAP transporter small transmembrane protein (probable substrate D-glucuronate/D-galacturonate);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS13265;G;;;;HELO_3409;TRAP transporter small transmembrane protein (probable substrate D-glucuronate/D-galacturonate);-1.0625315189757725;-0.45384649229101504;0.04916743525444556;-1.523988725893516;-0.4614572069177436
HELO_3410;11.989432313769527;21.887455311647756;44.91405665955302;33.17189665095391;52.82519130709783;49.65470502351884;1.149692731693992;1.6838416899678594;1.4904526304220445;0.8020900077143595;4.834730393773506;13.827819030873627;HELO_3410;TRAP transporter substrate-binding protein (probable substrate D-glucuronate/D-galacturonate);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS13270;G;;;;HELO_3410;TRAP transporter substrate-binding protein (probable substrate D-glucuronate/D-galacturonate);-0.8172186880709607;-0.14176037429027932;0.08758526319605942;-1.9633578978204573;-1.1461392097494967
HELO_3411;44.44145025950885;33.11766100633222;61.260253975740305;43.90385427902589;93.29576498135025;61.492039919989274;2.540615426132322;1.0928831347514743;4.276964843071218;3.697558286344657;2.319514665641842;5.83018240733848;HELO_3411;probable 2-ketoglutarate semialdehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS13275;I;;;1.2.1.26;HELO_3411;probable 2-ketoglutarate semialdehyde dehydrogenase;0.4134901353907221;-0.00536097263879487;0.5935205433391877;-0.4596635555348829;-0.873153690925605
HELO_3412;13.096223592594376;8.9703014698429;13.32188250845668;12.991665240659609;19.503644747327314;14.238841176154423;0.44099565240839217;0.1948297776618925;1.0883924218572287;1.4998153917409371;1.339761629614458;1.9135734132459223;gudD;glucarate dehydratase;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS13280;MR;gudD; glucarate dehydratase;4.2.1.40;gudD;glucarate dehydratase;0.49959968055412984;-0.08953206161366012;0.428127188797911;-0.11244448516068095;-0.6120441657148108
HELO_3413;11.743268127863788;6.9079649360015445;8.126173494282872;6.8508880284293285;8.548280148595236;7.676244733207902;0.8291856322055087;0.27765513673656783;1.2190620876686555;0.3680818075739776;1.0988929162612304;0.24123885505575884;garD;galactarate dehydratase;COG2721;Altronate dehydratase;UxaA;HELO_RS13285;G;garD; galactarate dehydratase;4.2.1.42;garD;galactarate dehydratase;0.6883569381381558;0.07293933250428708;0.1381701479460804;0.5545926642170071;-0.13376427392114865
HELO_3414;4.173543959725485;2.8484565341404253;2.7289931916831223;2.604913942450667;3.7402179265787936;3.4438151978133287;0.04140917719262373;0.1743995249887797;0.3963822888916344;0.2662076269688513;0.8817290044683023;0.5906038231020493;HELO_3414;TTT family transporter large transmembrane protein;COG3333;TctA family transporter;;HELO_RS13290;R;;garD;;HELO_3414;TTT family transporter large transmembrane protein;0.42687293510905566;-0.2530126584386767;0.09315456553856283;0.2193540666753635;-0.20751886843369216
HELO_3415;7.263839880649702;6.935499565601478;3.6971145573802833;2.7399773788294386;5.453203970984813;3.625427203573653;1.7641581628626317;1.3019368196203067;0.9419633736134061;1.0370365808618442;3.43286074086345;1.0670823175866209;HELO_3415;TTT family transporter small transmembrane protein;;;;;;;;;HELO_3415;TTT family transporter small transmembrane protein;0.058491252674725214;0.022188160924958122;0.4804290076646822;0.8372256821350237;0.7787344294602985
HELO_3416;15.68504942510358;16.700014284049484;19.365089433953745;14.630714346689183;25.741552988569836;26.23158764297742;1.0655950756917583;1.6926057495040883;0.8756930394143219;0.9073382941804333;7.92598291173874;6.687286081305989;HELO_3416;TTT family transporter substrate-binding protein;COG3181;Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC;TctC;HELO_RS13300;C;;;;HELO_3416;TTT family transporter substrate-binding protein;-0.08519456444085449;-0.41918294615134677;-0.026197845233304484;-0.706725136014831;-0.6215305715739765
HELO_3417;7.32423599171937;4.72624425198316;9.086888674336475;6.644028460187226;10.53804928053682;9.126031517464888;0.2317139959926794;0.2991028132450057;1.555755216158238;0.32882614128932863;1.0284052967398045;2.4515393412239255;HELO_3417;5-dehydro-4-deoxyglucarate dehydratase;COG0329;4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase;DapA;HELO_RS13305;ME;;;4.2.1.41;HELO_3417;5-dehydro-4-deoxyglucarate dehydratase;0.5397286564296429;-0.005587639561571045;0.18833045068339382;-0.28267910867722135;-0.8224077651068642
HELO_3418;41.51682118648628;28.094417489597152;23.893691290097703;25.943863097800186;30.580683235477874;20.988128973121828;2.9516864831886043;3.1061534171672935;1.7916483631952553;2.541929122075367;4.154171581556868;6.419885962329487;HELO_3418;AEC family transport protein;COG0679;Predicted permease, AEC (auxin efflux carrier) family;YfdV;HELO_RS13310;R;;;;HELO_3418;AEC family transport protein;0.5472913747024437;0.17905532534971158;0.5223175369114106;0.9513088895786783;0.4040175148762346
HELO_3419;96.71729968277975;70.09875684963559;15.79229517546728;19.47087313060063;43.09747942034044;30.930331673499463;2.12723242805601;1.2829916736262552;2.2928723051051496;1.9332004928664361;29.95134955143347;23.40797995620513;hmoB;heme-degrading monooxygenase HmoB;COG2329;Heme-degrading monooxygenase HmoA and related ABM domain proteins;HmoA;HELO_RS13315;H;hmoB; heme-degrading monooxygenase HmoB;;hmoB;heme-degrading monooxygenase HmoB;0.4587896619864793;-0.9271281071509145;0.46576865589337135;1.613686457907086;1.1548967959206067
HELO_3421;114.4285694734585;92.4704802283657;113.30460284390917;101.51543017573401;129.85800478705252;115.22895368286858;5.0712075781289085;0.5351731121671535;3.4631147596924334;4.212530976595094;8.31408185255381;3.7046080287551053;gpsA;glycerol-3-phosphate dehydrogenase%2C NAD(P)H-dependent;COG0240;Glycerol-3-phosphate dehydrogenase;GpsA;HELO_RS13325;C;gpsA; glycerol-3-phosphate dehydrogenase, NAD(P)H-dependent;1.1.1.94;gpsA;glycerol-3-phosphate dehydrogenase%2C NAD(P)H-dependent;0.30441763522060583;-0.024086002391227268;0.1710326770904631;-0.009969155404145447;-0.3143867906247513
HELO_3422;846.7899579249603;856.9828970550578;1738.939557730069;1121.07518364589;1593.8277781407223;1737.2438482422358;2.75979902422362;9.891905406553088;119.74678234749562;103.74751064277655;208.3563503123414;233.11339839389058;pntB;NAD(P) transhydrogenase beta subunit;COG1282;NAD/NADP transhydrogenase beta subunit;PntB;HELO_RS13330;C;pntB; NAD(P) transhydrogenase beta subunit;1.6.1.2,7.1.1.1;pntB;NAD(P) transhydrogenase beta subunit;-0.017242011706958493;0.0014067066495151437;-0.1242298447339234;-1.035851700868669;-1.0186096891617105
HELO_3423;1010.4337419014106;1160.7306741228588;2255.1964071087627;1469.3343660965063;1775.1337110176955;2324.9756305096776;32.02477445366026;50.07707979147718;80.53381353585779;49.76032430030543;149.6621960836087;170.80065988421413;pntA;NAD(P) transhydrogenase alpha subunit;COG3288;NAD/NADP transhydrogenase alpha subunit;PntA;HELO_RS13335;C;pntA; NAD(P) transhydrogenase alpha subunit;1.6.1.2,7.1.1.1;pntA;NAD(P) transhydrogenase alpha subunit;-0.19987383185084262;-0.04394331848402899;-0.38909578678160095;-1.2014341682630878;-1.0015603364122452
HELO_3424;347.65511766451823;214.47343593086612;264.53345755488266;569.8917575193195;207.81700338172092;248.56957329771026;51.829681979727326;3.606070363239174;35.22025957043482;28.982283720964073;5.828656247130017;32.56940041024572;htpG;chaperone protein HtpG;COG0326;Molecular chaperone, HSP90 family;HtpG;HELO_RS13340;O;htpG; chaperone protein HtpG;;htpG;chaperone protein HtpG;0.6942906366331192;0.08945159761850618;-0.2572028649890248;0.4823586018086914;-0.2119320348244278
HELO_3425;78.58892318131534;25.245929739428686;25.915162420939605;29.129284243814244;25.033714315630622;26.691345007813197;4.180230219205586;1.161112736311161;1.6900060893821063;3.6330732386037914;3.737197884901;1.9603151049041958;HELO_3425;thioesterase domain protein;COG2050;Acyl-CoA thioesterase PaaI, contains HGG motif;PaaI;HELO_RS13345;Q;;htpG;;HELO_3425;thioesterase domain protein;1.6004739524267295;-0.04101599774494158;-0.08905396867381832;1.5231325279620105;-0.07734142446471903
HELO_3426;201.5283957862698;58.70263899850628;61.142977412164214;72.99823671854635;64.35361800402858;64.53110597377022;5.998982992626497;4.261930713421827;5.467593603791521;3.1012968038944595;5.609073075489072;5.247090796347649;HELO_3426;esterase domain protein;COG2050;Acyl-CoA thioesterase PaaI, contains HGG motif;PaaI;HELO_RS13350;Q;;;;HELO_3426;esterase domain protein;1.762257588759776;-0.07658851447982329;-0.003912773972993833;1.6278724117938808;-0.13438517696589525
HELO_3427;95.71593521135456;30.848009456095696;58.30185125943902;68.73464862155433;52.22177613437933;44.17375370496567;7.9290420037676075;2.5409696717523884;6.43893505751119;13.233566147846105;2.0251679587730647;3.374420243843601;HELO_3427;DUF1232 domain protein;COG3339;Uncharacterized membrane protein YkvA, DUF1232 family;YkvA;HELO_RS13355;S;;;;HELO_3427;DUF1232 domain protein;1.6025504072078967;0.3925923436593113;0.23653185800825227;1.098268812862905;-0.5042815943449916
HELO_3428;148.05847631853035;73.60910428151736;188.46681175505844;208.17917592228727;168.67048529063104;191.8199787437569;6.333878847015628;2.51428039604307;17.37634486793749;9.265733970992647;9.45314767670012;10.166394019237087;slt;lytic murein transglycosylase Slt;COG0741;Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain);MltE;HELO_RS13360;M;slt; lytic murein transglycosylase Slt;4.2.2.-;slt;lytic murein transglycosylase Slt;0.9984548243243552;-0.025309383291545196;-0.18451891651702645;-0.37137612436380874;-1.369830948688164
HELO_3429;93.53653658539156;56.25809899567694;33.55414126101878;33.54810064166746;43.27473601252768;33.653506133632554;4.018809576961461;2.4027725246061094;1.3566872450465481;2.151084268958198;1.9716585129695716;3.4758624223742722;HELO_3429;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS13365;E;;slt;;HELO_3429;LysE family transport protein;0.723392238720999;-0.0041427013590809025;0.3534823778242293;1.4478706843548341;0.7244784456338351
HELO_3430;215.55567188000532;209.96923586411643;147.35969339596406;155.56397988066928;175.10063365707478;175.45785481831993;13.312321868183162;19.955720478671623;19.242330942248028;1.5232509561279852;11.483398838635933;17.064699849487436;HELO_3430;uncharacterized protein;COG2314;Uncharacterized membrane protein YozV, TM2 domain, contains pTyr;TM2;HELO_RS13370;R;;;;HELO_3430;uncharacterized protein;0.037705322632214155;-0.2502244600111414;-0.0029235510761278505;0.2954143075388167;0.25770898490660255
HELO_3431;23548.79216722984;15843.544289924599;23599.321700792512;16846.331985257337;20808.345191176348;24766.49772639004;1241.5599669159658;2838.6666728244313;890.3396322896903;637.8264792466994;979.5258265449871;1945.468658619022;cspA3;cold shock protein CspA;COG1278;Cold shock protein, CspA family;CspC;HELO_RS13375;K;cspA3; cold shock protein CspA;;cspA3;cold shock protein CspA;0.5717281612548355;-0.06964159430001082;-0.25121655126882025;-0.07273379193927987;-0.6444619531941154
HELO_3432;372.4465008050492;162.49921485772688;298.7639831228086;248.1714166788539;283.94542728751463;264.2522070212255;15.86940058570567;3.1665551332989175;19.4167608365045;18.345751315544817;40.94694321335462;23.570356284191575;HELO_3432;uncharacterized protein;;;;;;;;;HELO_3432;uncharacterized protein;1.1916178724755877;0.17646229767916566;0.10332088587872867;0.4935368251449912;-0.6980810473305965
HELO_3433;246.06247847119047;84.43012646631888;290.14260698442314;254.04066636815864;303.5359840437704;305.4252722237471;7.064376635130124;4.3696724788173835;15.716765024680425;8.002116280201413;15.442753563723999;7.224063713481749;HELO_3433;glyoxalase domain protein;COG3565;Predicted dioxygenase of extradiol dioxygenase family;;HELO_RS13385;R;;;;HELO_3433;glyoxalase domain protein;1.5320591011381763;-0.07380930277160047;-0.008922580108530198;-0.3106593631691945;-1.8427184643073709
HELO_3434;89.56765423090026;47.30084391866405;113.60875168076348;123.2290360986638;121.77381275256816;124.99129656250739;2.8835758750544223;0.742003354417469;13.980999535009463;1.9290280174186734;2.969886550591405;8.758248755090895;yegS;probable lipid kinase%2C YegS-type;COG1597;Phosphatidylglycerol kinase, diacylglycerol kinase family;LCB5;HELO_RS13390;IR;yegS; probable lipid kinase, YegS-type;;yegS;probable lipid kinase%2C YegS-type;0.9069474949523144;-0.1366068618020888;-0.03732120481667067;-0.47625627996378483;-1.3832037749160992
HELO_3435;26.699127037775032;13.168004940717324;17.020093833717407;25.698012387139055;16.17461957819261;16.92317561091983;1.4131876739980542;1.0272603608728577;1.1910683544039218;1.5443552141346963;1.2760853001350538;1.1787143783952527;HELO_3435;cation/proton antiporter family protein;COG4651;Predicted Kef-type K+ transport protein, K+/H+ antiporter domain;RosB;HELO_RS13395;P;;yegS;;HELO_3435;cation/proton antiporter family protein;0.9672038888900505;0.007780248176350035;-0.06154813198753839;0.6280142338393446;-0.33918965505070586
HELO_3436;82.57173497450218;25.10835653966402;33.13143515655177;33.200655151715836;25.082029879032984;31.38815422999271;2.8213987091273065;2.3479607869556154;6.37174409390371;1.072784179428998;1.3490768514967875;6.214296705382059;HELO_3436;uncharacterized protein;;;;;;;;;HELO_3436;uncharacterized protein;1.678503440747054;0.07563482540539912;-0.3124100984896119;1.3675488342958557;-0.3109546064511983
HELO_3437;132.2031335837652;162.31802449410833;177.3353501856151;115.75265002691786;216.9607669326675;187.59341140727955;5.349099157948773;3.0924859628624066;11.625145032486726;7.829866924020999;7.769280973917911;12.682551423670558;pepN;aminopeptidase PepN;COG0308;Aminopeptidase N, contains DUF3458 domain;PepN;HELO_RS13405;E;pepN; aminopeptidase PepN;3.4.11.2;pepN;aminopeptidase PepN;-0.29405599985113895;-0.08068656892491788;0.20878919669244134;-0.5016512537225424;-0.20759525387140343
HELO_3438;104.21845022961237;41.01883941234891;54.9839406902463;55.959706525048894;65.3689599339238;55.928876113879795;2.118008073330476;6.475899620993304;5.6279672168630075;5.04523355284174;6.326563179928789;9.216921956557698;HELO_3438;DUF454 domain protein;COG2832;Uncharacterized membrane protein YbaN, DUF454 family;YbaN;HELO_RS13410;S;;pepN;;HELO_3438;DUF454 domain protein;1.3242794862798375;-0.02414757712915616;0.2213480475553018;0.8861551822467346;-0.4381243040331029
HELO_3439;46.903785182043585;12.501961680342754;26.5815629607356;31.604475637683652;30.721454151868073;23.79717695469976;1.4939108681684192;1.600675404354786;3.547531459383969;5.3449326369367425;2.727727661422189;1.9672841745849374;HELO_3439;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS13415;J;;;2.3.1.266;HELO_3439;GNAT family acetyltransferase;1.8269706273902817;0.1535283264532481;0.35528302181450133;0.949963771233568;-0.8770068561567137
HELO_3440;41.146264288573384;48.5384986948159;76.74119641774149;64.86674058441452;75.48743887089152;81.64366631920177;2.7142393047917577;3.449496954526229;3.9429419144038613;3.759323334076741;9.201006369036973;7.811077831709558;cobO2;cob(I)yrinic acid a%2Cc-diamide adenosyltransferase;COG2109;ATP:corrinoid adenosyltransferase;BtuR;HELO_RS13420;H;cobO2; cob(I)yrinic acid a,c-diamide adenosyltransferase;2.5.1.17;cobO2;cob(I)yrinic acid a%2Cc-diamide adenosyltransferase;-0.23314538626648762;-0.0882249473049237;-0.11168141681986476;-0.9714994969583346;-0.738354110691847
HELO_3441;100.13998699448551;22.587285736459716;46.63518180093732;58.648480880539346;52.71788345350737;46.86635987557863;3.585586774773065;0.9104843715262773;1.5423556181964222;2.481928172647346;4.3535657062645425;1.3970399329064176;HELO_3441;exonuclease domain protein;COG0847;DNA polymerase III, epsilon subunit or related 3'-5' exonuclease;DnaQ;HELO_RS13425;L;;cobO2;2.7.7.7;HELO_3441;exonuclease domain protein;2.1002721803009354;-0.0069846016604913075;0.16639036538406948;1.0792694962956686;-1.0210026840052668
HELO_3442;118.31351279574949;43.10246704124603;68.0925300013298;84.52631309774698;56.93704873398024;65.19230092201867;6.460242211459199;3.494553582536496;3.964769893031619;6.547598922710407;2.883342340967448;5.151109898378362;HELO_3442;DUF294 / CBS domain protein;COG2905;Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains;;HELO_RS13430;T;;;;HELO_3442;DUF294 / CBS domain protein;1.435826178181447;0.061866319372160916;-0.19217722467882759;0.8500221174717888;-0.5858040607096582
HELO_3443;4183.987740047332;2912.90546995024;1359.5720106356684;922.6381056219634;1301.818161420023;1575.2532906977758;246.69012789974158;274.120906261407;192.0558610323959;278.6805544236068;922.6863894067315;995.620331139268;HELO_3443;DUF4168 domain protein;;;;;;;;;HELO_3443;DUF4168 domain protein;0.5222693207252203;-0.2122860666808304;-0.27486364612394;1.4087240139671984;0.8864546932419781
HELO_3444;18.97315815029431;6.552578369745615;10.58838509700748;11.258308767626724;12.146218256391116;9.318923142069478;1.2571064667506269;0.6961368688429388;0.9496712462986671;1.433707962539892;0.30615852326051013;1.2949922354637975;purU2;formyltetrahydrofolate deformylase;COG0788;Formyltetrahydrofolate hydrolase;PurU;HELO_RS13440;F;purU2; formyltetrahydrofolate deformylase;3.5.1.10;purU2;formyltetrahydrofolate deformylase;1.4030213150152804;0.16738711069587353;0.3493554198577238;0.9527700469217097;-0.45025126809357063
HELO_3445;29.637470909411917;8.960013042218335;13.343903741332454;10.556303449555953;16.424312762657703;12.553914276648415;1.0511565282998099;0.8179369854416019;1.083952910510413;0.9333843846809978;2.040503102848934;0.7308974970434243;soxG;sarcosine oxidase gamma subunit;COG4583;Sarcosine oxidase gamma subunit;SoxG;HELO_RS13445;E;soxG; sarcosine oxidase gamma subunit;1.5.3.1;soxG;sarcosine oxidase gamma subunit;1.6210776726835197;0.0817281596575854;0.3623922033684921;1.1765876571429064;-0.4444900155406133
HELO_3446;25.957280186444823;12.426325467157701;21.35943739042044;19.1104908332026;26.13330065890356;22.033010153171944;1.9576157467462487;0.6281593708168185;1.6405080223033828;1.0391022940847867;1.4836501885823876;1.8835876217023042;soxA;sarcosine oxidase alpha subunit;COG0446;NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase;FadH2;HELO_RS13450;I;soxA; sarcosine oxidase alpha subunit;1.5.3.1;soxA;sarcosine oxidase alpha subunit;1.005610425074678;-0.0428190798761614;0.2363615891209907;0.22697197802259428;-0.7786384470520837
HELO_3447;18.104302900012858;8.998585535704947;9.622812740807435;6.0809236673052665;8.340397052596643;10.954975204345239;2.1748558339671877;0.26538370107377907;0.7232919169535388;1.372069369873616;0.8516773729433402;1.4920694128937952;soxD;sarcosine oxidase delta subunit;COG4311;Sarcosine oxidase delta subunit;SoxD;HELO_RS13455;E;soxD; sarcosine oxidase delta subunit;1.5.3.1;soxD;sarcosine oxidase delta subunit;0.9341016944198368;-0.1704453198533833;-0.3560553536473412;0.6762864781459257;-0.25781521627391113
HELO_3448;17.849100270245298;5.186321405084139;10.5133369895036;8.054810595475765;13.518934177213596;11.439095493415742;0.7556116010515532;0.371049405016596;1.0809703973576734;0.20103096534404624;0.396523422718893;1.2294168020499265;soxB;sarcosine oxidase beta subunit;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS13460;E;soxB; sarcosine oxidase beta subunit;1.5.3.1;soxB;sarcosine oxidase beta subunit;1.6073419660577346;-0.11157554368548084;0.22305396621439666;0.5996140765696643;-1.0077278894880703
HELO_3449;21.0434144645791;7.360524432414425;16.001235496586947;13.782763991134985;20.226585607962686;17.533873325976277;1.8538283269769635;0.2723603165848446;1.8596204587832066;0.5041465893698672;0.9313458147195803;2.307790649106012;glyA2;glycine hydroxymethyltransferase;COG0112;Glycine/serine hydroxymethyltransferase;GlyA;HELO_RS13465;E;glyA2; glycine hydroxymethyltransferase;2.1.2.1;glyA2;glycine hydroxymethyltransferase;1.39868236423283;-0.12452482415449762;0.19570790949929595;0.25018329433051;-1.14849906990232
HELO_3450;26.21337405586173;14.746059617859055;22.650818275834638;25.76352907854121;23.096470941017575;21.215180416888813;1.492295888195925;1.7325144737134055;3.265322543751331;2.6491524892246523;2.694317340649179;1.2948840194081086;HELO_3450;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS13470;K;;glyA2;;HELO_3450;PfpI/HTH domain protein (homolog to transcription regulator CdhR);0.7893249948316838;0.09034424108240025;0.11727601340226279;0.29276998251998343;-0.4965550123117004
HELO_3451;8.732343104926;3.7336711372494826;3.894644920899641;4.043132626918944;3.3850606880383958;3.7064099002433886;0.19212455613031482;0.28812029465912675;0.7562746323984034;0.2591138871370476;0.11924748678808314;0.1956405371916555;hpbC;probable iron-sulfur protein (2Fe-2S) HpbC;COG1018;Flavodoxin/ferredoxin--NADP reductase;Fpr;HELO_RS13475;C;hpbC; probable iron-sulfur protein (2Fe-2S) HpbC;;hpbC;probable iron-sulfur protein (2Fe-2S) HpbC;1.0398277010028805;0.05657722800145226;-0.1020301668589072;1.0481602059064556;0.008332504903575177
HELO_3452;10.41197963093171;2.418635524452667;3.958630359861537;4.289378895890373;4.455753565918735;3.9238650231310097;0.4762023168882484;0.29723775067552405;0.8751969508088419;0.6974138101491766;0.27723681816171075;0.49367894143440794;hpbB;stachydrine demethylase;COG4638;Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit;HcaE;HELO_RS13480;PR;hpbB; stachydrine demethylase;;hpbB;stachydrine demethylase;1.739056552877544;0.01015046986680801;0.14798726583810096;1.2126859578067326;-0.5263705950708113
HELO_3453;35.393327439748504;9.019798880302643;47.419180253582645;51.8347189888575;40.93051070713881;44.4443486239907;4.7755574587777865;1.7294521446800784;7.234548412753059;11.557480049077423;6.49376794469527;2.293113048528262;HELO_3453;uncharacterized protein;;;;;;;;;HELO_3453;uncharacterized protein;1.8608204120126501;0.09147775976805139;-0.11610049256572186;-0.32042693192842275;-2.181247343941073
HELO_3454;13.308348312116784;2.9599533785367584;4.880870662784978;7.354046219332621;5.802888512729602;5.657991614645841;0.6132814508441476;0.5270406645160322;0.3809339239568755;0.731520531014962;0.9248316274078116;0.9392221413425198;fdhA;formaldehyde dehydrogenase%2C glutathione-independent;COG1063;Threonine dehydrogenase or related Zn-dependent dehydrogenase;Tdh;HELO_RS13490;ER;fdhA; formaldehyde dehydrogenase, glutathione-independent;1.2.1.46;fdhA;formaldehyde dehydrogenase%2C glutathione-independent;1.8533017934721219;-0.17905729164216;0.031060392603432074;1.1036981852000678;-0.7496036082720541
HELO_3455;80.11332805299773;29.20438335947942;69.54473178894715;68.98705846558619;114.9193929425342;66.22247925793175;12.579752381244058;3.8588335058598173;1.4263537029788194;9.67419363544887;8.073002856669808;5.361575988626329;HELO_3455;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS13495;G;;fdhA;;HELO_3455;major facilitator superfamily transport protein;1.4251810554764122;0.06959459558733627;0.7861062874610081;0.27099523665692526;-1.154185818819487
HELO_3456;1003.859982985607;396.65482450029657;992.3146318722339;721.656994912315;1098.294542664979;1081.603585644116;51.80079138544861;17.16121904059181;73.44218254077879;32.48144642547502;132.00454556413223;88.58366593292808;HELO_3456;IalB domain protein;COG5342;Invasion protein IalB, involved in pathogenesis;IalB;HELO_RS13505;R;;;;HELO_3456;IalB domain protein;1.3374059110607401;-0.12418240333223451;0.022072919293401938;-0.10751058092697008;-1.4449164919877102
HELO_3457;13.849946170328431;5.907067986500917;7.745888982349176;6.298713782356368;7.724882168084278;5.977367272248671;1.1761900570753128;0.5389405708472922;1.3320297065499986;0.8718860335451267;0.47391316523732563;0.765618728616221;HELO_3457;EtfB family protein;COG2086;Electron transfer flavoprotein, alpha and beta subunits;FixA;HELO_RS13510;C;;;;HELO_3457;EtfB family protein;1.1043123720728296;0.3259222596797562;0.3224528717392725;1.0897030205635714;-0.01460935150925824
HELO_3458;13.281060322788202;6.247824577506878;8.570031361427441;8.84850956597009;8.558550620873664;6.764611449098616;0.7831414292085552;0.30367511930738167;1.3036838175242627;0.5808071426253625;0.3658808617754037;0.7518204292101188;HELO_3458;EtfA family protein;COG2025;Electron transfer flavoprotein, alpha subunit FixB;FixB;HELO_RS13515;C;;;;HELO_3458;EtfA family protein;0.978483156113958;0.30160992034776823;0.29987814436282356;0.8791174615483839;-0.09936569456557409
HELO_3459;10.376975114445441;4.659826618099253;8.4765774431314;8.03779161804319;9.355157405212857;7.972987070585951;0.9475230949444327;0.17062210181331278;0.6540568989672763;0.28179693121936117;1.0436717569150218;0.8363537633467778;HELO_3459;DUF3483 domain protein / 4Fe-4S ferredoxin domain protein;COG0247;Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF;GlpC;HELO_RS13520;C;;;;HELO_3459;DUF3483 domain protein / 4Fe-4S ferredoxin domain protein;1.0072872643490376;0.07877777767196337;0.2066892461647658;0.34245679051368505;-0.6648304738353525
HELO_3460;8.569926160161195;2.456148885210875;6.723557499543472;7.415711653708084;6.583790217118628;6.326839737104318;0.11809151586905546;0.3323778939630503;0.6446490348757277;0.23584729424712933;0.20746148836380535;0.45849681240192836;hpbA;N-methylproline demethylase;COG1902;2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family;FadH;HELO_RS13525;C;hpbA; N-methylproline demethylase;;hpbA;N-methylproline demethylase;1.4693424254071852;0.07607445194671225;0.049727997566488824;0.3853167338004293;-1.0840256916067559
HELO_3461;8.395291159305517;2.1494626574307594;4.5040735092964574;5.062316891937311;6.06359167108307;6.05078119407749;0.9014393251151459;0.09420216307338948;0.08387530241094023;1.2718620587296712;1.1017912574730453;1.8604277008779644;HELO_3461;uncharacterized protein;;;;;;;;;HELO_3461;uncharacterized protein;1.5768321657708193;-0.35728337234330976;0.0026188364015631294;0.41415476100761817;-1.1626774047632011
HELO_3462;8.35817699781304;4.679666052374018;3.47869997572214;5.228610318747117;3.6306824608511996;3.2910086421561675;0.8237080708146545;0.2493865119090571;0.3907494748646786;0.40884195151761166;0.04224025897676312;0.23716954203951646;HELO_3462;peptidase M19 family protein;COG2355;Zn-dependent dipeptidase, microsomal dipeptidase homolog;;HELO_RS13535;OE;;;3.4.13.19;HELO_3462;peptidase M19 family protein;0.7204214096600112;0.061763217825810734;0.10990802400681288;1.1249107089680237;0.4044892993080125
HELO_3463;155.13996096358625;106.6871344746336;109.26010443892693;124.30608530366419;103.80748735724676;100.71194340909845;8.59736022064858;5.892977089772434;2.0711111392774866;3.0584488674951036;4.059698498712079;3.4661922694924487;mtgA;biosynthetic peptidoglycan transglycosylase MtgA;COG0744;Penicillin-binding protein 1B/1F, peptidoglycan  transglycosylase/transpeptidase;MrcB;HELO_RS13540;M;mtgA; biosynthetic peptidoglycan transglycosylase MtgA;2.4.1.129;mtgA;biosynthetic peptidoglycan transglycosylase MtgA;0.535993914620259;0.11642177710607804;0.04325268949239547;0.6183507181355692;0.08235680351531016
HELO_3464;147.83587509145647;33.42823441067916;147.43440461125167;168.3913061972318;167.39461194367323;162.76925274130977;4.522755622555264;3.0101850709790248;9.86481421406595;5.1884973296918995;2.0780462590473587;4.323133477058986;HELO_3464;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS13545;K;;mtgA;;HELO_3464;PfpI/HTH domain protein (homolog to transcription regulator CdhR);2.112058210661859;-0.14183899680744805;0.04018145770016179;-0.1379422075046559;-2.2500004181665147
HELO_3465;91.53170173129196;100.31611551470786;104.9249649123821;90.69242273293214;105.73948996433215;111.29767120715871;2.61975539575938;2.5202344329362174;2.497874589415336;6.648221306809158;3.70488076158534;7.101356083941121;yeiG;S-formylglutathione hydrolase YeiG;COG0627;S-formylglutathione hydrolase FrmB;FrmB;HELO_RS13550;V;yeiG; S-formylglutathione hydrolase YeiG;3.1.2.12;yeiG;S-formylglutathione hydrolase YeiG;-0.13084404140844352;-0.0842853590953423;-0.07323398711117157;-0.2793083813797965;-0.148464339971353
HELO_3466;46.08802020049467;71.14800335753115;85.35555404887526;89.10517418205511;86.42605304424315;90.17278478318734;0.85012553582807;3.882190623738638;6.636491043825337;1.7029655834695612;4.2125926941508025;6.585400749091425;frmA;formaldehyde dehydrogenase%2C glutathione-dependent;COG1062;Zn-dependent alcohol/formaldehyde dehydrogenase;FrmA;HELO_RS13555;C;frmA; formaldehyde dehydrogenase, glutathione-dependent;1.1.1.284,1.1.1.1;frmA;formaldehyde dehydrogenase%2C glutathione-dependent;-0.6155994034548451;-0.0783142727607462;-0.060539973710696415;-0.9532431756586695;-0.33764377220382435
HELO_3467;18.854507139550787;10.63633575701622;18.711689524820894;25.32626250699802;14.567359523922427;19.82288356334482;1.0152003235977267;0.7982726216216965;1.5352935435229693;1.6287225981172981;0.649667437261673;0.8758206406592477;HELO_3467;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS13560;K;;frmA;;HELO_3467;LysR family transcription regulator;0.7708297184696145;-0.07911842990218343;-0.4196456068599055;-0.06870331918903094;-0.8395330376586454
HELO_3468;10.724960408635406;5.559104539180404;6.1455297037821985;7.201384037416626;5.449254017620899;6.809254187898287;0.6011967348485685;0.5704742674064547;0.43157083286177145;0.49918429376779516;0.9813057062932957;0.21674556682022952;sdaA;L-serine dehydratase;COG1760;L-serine deaminase;SdaA;HELO_RS13565;E;sdaA; L-serine dehydratase;4.3.1.17;sdaA;L-serine dehydratase;0.8380122771765488;-0.12814380892409583;-0.2760524780518985;0.5863263737892774;-0.25168590338727137
HELO_3469;21.711792126329232;14.590005675508058;25.668324834097785;21.996714730021083;26.317671716455862;27.948393622389336;2.1646703105290714;1.3153602514922662;5.258088058829497;2.6015927774768963;3.2499501009387437;2.018678030009368;HELO_3469;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS13570;K;;sdaA;;HELO_3469;LysR family transcription regulator;0.5428200964695229;-0.11835608861826952;-0.08364876567579937;-0.3500417440151544;-0.8928618404846773
HELO_3470;24.005166534869556;19.092277287211047;16.718719102988544;12.02217741748145;16.137206463378927;18.046036802588223;0.31712637926026926;0.4961615638768704;0.7910557488775667;2.8225903179165717;2.6658223929302913;3.253977596569545;HELO_3470;uncharacterized protein;;;;;;;;;HELO_3470;uncharacterized protein;0.3155851230119131;-0.10421651117722508;-0.1523588706877863;0.3927353879178064;0.07715026490589327
HELO_3471;646.4773998221049;555.3175996573001;560.9052226301601;686.8964021978568;542.5990645032097;526.9691785422519;25.961371187632828;24.03548769576058;29.126462526004286;28.738234250625297;57.30055595379069;19.188962473955236;rpoD;RNA polymerase sigma-70 factor;COG0568;DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32);RpoD;HELO_RS13580;K;rpoD; RNA polymerase sigma-70 factor;;rpoD;RNA polymerase sigma-70 factor;0.2189210890563409;0.08987309821454836;0.042089262043750963;0.29437612516960243;0.07545503611326154
HELO_3472;283.3829113811348;564.4120231931664;419.16997721534113;432.6094951143394;352.9282637757029;389.0994741283894;8.082851555935438;27.833301362696776;32.11925692202589;18.812160242006687;35.43115860857351;37.56773386737543;dnaG;DNA primase;COG0358;DNA primase (bacterial type);DnaG;HELO_RS13585;L;dnaG; DNA primase;2.7.7.101;dnaG;DNA primase;-0.9914677858917642;0.10713102595661717;-0.14038507736963446;-0.4560072777814348;0.5354605081103294
HELO_3473;4827.111861071097;1836.1705522083478;5436.420274803906;4315.420444622485;3117.8669054335314;4086.878376212391;1058.8437535696771;300.5334916570717;483.8283756055366;878.7840292486081;145.41334159469446;717.6284939437434;rpsU;30S ribosomal protein S21;COG0828;Ribosomal protein S21;RpsU;HELO_RS13590;J;rpsU; 30S ribosomal protein S21;;rpsU;30S ribosomal protein S21;1.3939735377805462;0.4115700693303861;-0.3903302849781447;0.24010682843044506;-1.1538667093501012
HELO_3474;163.96764475156965;98.25265514949585;170.8074717089522;222.76976340124028;203.16718509573232;172.06466161490002;3.1502245033943983;6.773459405034422;6.5386307968237425;7.591201723523377;16.20455319722673;9.568646944526627;tsaD;tRNA N6-adenosine threonylcarbamoyltransferase;COG0533;tRNA A37 threonylcarbamoyltransferase TsaD;TsaD;HELO_RS13595;J;tsaD; tRNA N6-adenosine threonylcarbamoyltransferase;2.3.1.234;tsaD;tRNA N6-adenosine threonylcarbamoyltransferase;0.7330054931498546;-0.010518389291103603;0.23843983846816563;-0.0691280731007895;-0.8021335662506441
HELO_3475;98.12633646230832;71.34142315579594;121.74978575017589;164.95820311120033;132.3822519603358;117.68623112988116;9.509488720259194;1.0998301762215268;2.4747991407951178;4.853860524435237;3.6581210673203466;12.886091769456222;plsY;glycerol-3-phosphate acyltransferase;COG0344;Phospholipid biosynthesis protein PlsY, probable glycerol-3-phosphate acyltransferase;PlsY;HELO_RS13600;I;plsY; glycerol-3-phosphate acyltransferase;2.3.1.275;plsY;glycerol-3-phosphate acyltransferase;0.4544464318866437;0.04856792977688773;0.16841413550002127;-0.25981225958553456;-0.7142586914721782
HELO_3476;116.95627600687264;145.6506012109448;130.1191426485167;152.28506036759757;143.891136284853;113.47968778892461;4.842401894946171;14.818633169996131;9.044009242707054;5.778155574524871;7.874148519340694;7.534104431193172;folB;dihydroneopterin aldolase;COG1539;Dihydroneopterin aldolase;FolB;HELO_RS13605;H;folB; dihydroneopterin aldolase;4.1.2.25,5.1.99.8,1.13.11.81;folB;dihydroneopterin aldolase;-0.3141308046399338;0.19578668356200968;0.33987769808773916;0.04316053832213029;0.3572913429620641
HELO_3477;127.2095420288877;165.10498200620916;95.91018448261401;126.05010986716347;128.19769494340173;105.80393081245477;14.955737008439941;4.886751871017414;4.367199976220169;6.699720025559997;2.9265287171397545;9.01798687638019;HELO_3477;homolog to 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase;COG0801;7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis);FolK;HELO_RS13610;H;;folB;2.7.6.3;HELO_3477;homolog to 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase;-0.37359170596043967;-0.1402445505683083;0.27461558572795397;0.26353889395159413;0.6371305999120338
HELO_3478;260.49483909512446;254.51675541121816;209.03521591581287;215.92303338833923;222.79769153148246;198.3796794486069;7.217927964878414;17.61272571086504;4.54384087788899;13.257823987759249;2.3810181813570632;7.979192556215058;cca;multifunctional CCA processing protein;COG0617;tRNA nucleotidyltransferase/poly(A) polymerase;PcnB;HELO_RS13615;J;cca; multifunctional CCA processing protein;2.7.7.72,3.1.3.-,3.1.4.-;cca;multifunctional CCA processing protein;0.03336457506067614;0.07511286073630608;0.16667677563985883;0.39126409410615004;0.3578995190454739
HELO_3479;233.66109302709916;207.6053249579086;79.79887646983536;68.52223382116188;85.50350670997757;82.80969459564879;22.997664235496096;6.197181546462906;9.903847359141706;3.2445916141328452;7.108284715707372;26.401270739131835;glpE;thiosulfate sulfurtransferase GlpE;COG0607;Rhodanese-related sulfurtransferase;PspE;HELO_RS13620;P;glpE; thiosulfate sulfurtransferase GlpE;2.8.1.1;glpE;thiosulfate sulfurtransferase GlpE;0.169802676602834;-0.05278190371063207;0.045641482656836097;1.4853896209683262;1.3155869443654922
HELO_3480;341.9010167491958;332.82318360643336;255.95986823066846;245.69239442791044;236.01783375406913;251.8781249447436;9.012185636404272;18.094113945229186;13.687149543657936;11.355246341809124;6.237221967788875;17.62544327764595;apaH;bis(5'-nucleosyl)-tetraphosphatase%2C symmetrical;;;;;;;;;apaH;bis(5'-nucleosyl)-tetraphosphatase%2C symmetrical;0.038708030508642466;0.023100815135698838;-0.09344662819436511;0.43934993905470243;0.40064190854605997
HELO_3481;232.46795506048102;191.42644959852842;124.11923000953993;121.27477223886889;131.09577583755456;141.89918389386432;2.02533726924169;4.570844448627427;10.126757982910723;23.165492463176577;4.826460476253899;17.5915231962028;apaG;ApaG family protein ApaG;COG2967;Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport;ApaG;HELO_RS13630;P;apaG; ApaG family protein ApaG;;apaG;ApaG family protein ApaG;0.2789174290480112;-0.1916941377735899;-0.11341334435639805;0.7082268674543934;0.42930943840638225
HELO_3482;305.83518598946245;240.07347731402356;218.84005770950247;236.62590302385286;219.79085621127197;244.11553466167962;17.126932280472968;3.5411686609036157;7.501036730047155;7.225622558574822;9.152317710361315;30.706673408454172;rsmA;ribosome biogenesis protein RsmA%2C 16S rRNA-methylating;COG0030;16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity);RsmA;HELO_RS13635;J;rsmA; ribosome biogenesis protein RsmA, 16S rRNA-methylating;2.1.1.182;rsmA;ribosome biogenesis protein RsmA%2C 16S rRNA-methylating;0.3479909961364154;-0.15700763264951512;-0.15078149476847358;0.32400201116832594;-0.023988984968089433
HELO_3483;380.1163167177736;220.3281293230676;308.22073232612684;325.2783667734289;346.1824456730936;326.18737492828836;32.2868853292516;1.2943768150851191;9.098552770375543;11.679047050273102;19.821653627567127;3.2000549443207778;pdxA1;4-hydroxythreonine-4-phosphate dehydrogenase;COG1995;4-hydroxy-L-threonine phosphate dehydrogenase PdxA;PdxA;HELO_RS13640;H;pdxA1; 4-hydroxythreonine-4-phosphate dehydrogenase;1.1.1.262;pdxA1;4-hydroxythreonine-4-phosphate dehydrogenase;0.784044555847939;-0.08148002965705992;0.08557692315953602;0.2201142949637127;-0.5639302608842263
HELO_3484;506.5513996547711;240.3185923177945;402.7335342386427;393.17650816724796;436.47203940786034;426.167034511139;16.06965506473837;6.411099854598705;17.81533000200726;4.651523751411695;12.894484128763516;15.851429537184877;surA;PpiC-type peptidyl-prolyl cis-trans isomerase SurA;;;;;;;;;surA;PpiC-type peptidyl-prolyl cis-trans isomerase SurA;1.072614859370594;-0.08139689262334748;0.034390496328931874;0.24875361607054103;-0.823861243300053
HELO_3485;266.16072429911793;136.2911660124877;196.3207442499074;194.83033055719156;177.42425937195117;199.4594173257299;4.5285630858573604;2.7367630766351785;20.611861435225737;12.706993776412613;5.81057913051075;8.117746824730856;lptD;LPS-assembly protein LptD;COG1452;LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA);LptD;HELO_RS13650;M;lptD; LPS-assembly protein LptD;;lptD;LPS-assembly protein LptD;0.9604691322362537;-0.022767561059407804;-0.16799841108026392;0.4143977355881949;-0.5460713966480588
HELO_3486;150.9535822155215;101.51142693906029;121.08511276681004;113.68198590202867;106.43307931509283;124.76911492064856;9.215715735173424;7.170084751026718;6.353590378225725;6.108457782571686;6.710053525547597;6.291062642082747;HELO_3486;kinase domain protein;COG3178;Predicted phosphotransferase, aminoglycoside/choline kinase (APH/ChoK) family;;HELO_RS13655;R;;lptD;2.7.1.221;HELO_3486;kinase domain protein;0.5678459501662969;-0.04289039681859741;-0.22733940704782274;0.2728530023670688;-0.29499294779922813
HELO_3487;193.22935292120425;153.74533441303177;146.35516171302325;145.19295842174924;148.92564303784852;161.49303637343252;8.332715318175076;6.008968273976566;3.6678266480573853;7.7381429462883835;9.965780007058584;7.399262311962128;HELO_3487;nucleotidyltransferase domain protein;COG1208;NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s;GCD1;HELO_RS13660;JM;;;2.7.7.99;HELO_3487;nucleotidyltransferase domain protein;0.3278653318989493;-0.14108029528052324;-0.11613073227980131;0.25738335171670723;-0.07048198018224205
HELO_3488;204.1393034245053;154.73807470743202;220.51659412320885;195.6201380023225;257.4575292435429;221.7819732125084;4.518824286916236;1.5662682867043307;11.945078757818072;7.670267338510282;30.90167742814086;18.688070622222895;HELO_3488;OsmC domain protein;COG1765;Uncharacterized OsmC-related protein;YhfA;HELO_RS13665;R;;;;HELO_3488;OsmC domain protein;0.3974822334138981;-0.008217722077465517;0.21429473145601996;-0.11902856947728235;-0.5165108028911805
HELO_3489;283.5293702828371;170.90016454210277;142.8363119467133;145.97749292594366;126.74956367009706;143.49706441024932;15.167512425717266;0.4513769326362819;5.711735903109249;1.7898202057570476;12.138259153479709;7.235089478022444;speD;S-adenosylmethionine decarboxylase;COG1586;S-adenosylmethionine decarboxylase;SpeD;HELO_RS13670;E;speD; S-adenosylmethionine decarboxylase;4.1.1.50;speD;S-adenosylmethionine decarboxylase;0.7270066553304586;-0.006612248523942377;-0.17772181972504786;0.9775373977314947;0.2505307424010361
HELO_3490;384.9890980697739;131.87989905470624;234.45355807267197;229.49656160451525;265.1303018693809;223.66410774658527;28.39843023675843;8.638524344417227;18.832289304119307;19.630374734398277;18.653454838503762;11.50746487716779;coq7;2-nonaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol hydroxylase;COG2941;Demethoxyubiquinone hydroxylase, CLK1/Coq7/Cat5 family (ubiquinone biosynthesis);Coq7;HELO_RS13675;H;coq7; 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase;1.14.99.60;coq7;2-nonaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol hydroxylase;1.5384372179510617;0.0676728656783121;0.2443631279416545;0.7807904418782856;-0.7576467760727761
HELO_3491;421.3663748657821;224.15894525765057;230.78890465020177;170.63969616322197;170.15412283855596;192.070675868135;55.5030003118699;45.58164610556592;31.361887645686938;64.03901607514767;10.07404894065281;14.824811995431784;hinT;adenosine phosphoramidase HinT;COG0537;Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family;HinT;HELO_RS13680;FR;hinT; adenosine phosphoramidase HinT;;hinT;adenosine phosphoramidase HinT;0.9075511893233283;0.2636824483446194;-0.1738330151753873;1.1293659242092735;0.22181473488594516
HELO_3492;10.545213444876737;3.794085770253933;11.912536874394354;11.284075920662909;16.988401606851287;12.494169614765491;0.35724865770487696;0.18092546456715297;2.253090779093016;0.634591433328686;0.9041403316266431;0.9090097530881234;rbtD;ribitol 2-dehydrogenase;COG4221;NADP-dependent 3-hydroxy acid dehydrogenase YdfG;YdfG;HELO_RS13690;C;rbtD; ribitol 2-dehydrogenase;1.1.1.56;rbtD;ribitol 2-dehydrogenase;1.267967220159448;-0.06356373199001863;0.414730797914443;-0.22504135547153892;-1.493008575630987
HELO_3493;1.1335058263977034;0.6207785893805999;12.583082666151677;10.39703657045285;9.120784242897235;13.692975264149213;0.2390922003657054;0.16718437790081547;0.9642870094593138;0.2946035196181552;0.603142831642594;3.1931593655084773;rbsB;ABC-type transport system periplasmic substrate-binding protein (probable substrate ribose);COG1879;ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain;RbsB;HELO_RS13695;G;rbsB; ABC-type transport system periplasmic substrate-binding protein (probable substrate ribose);;rbsB;ABC-type transport system periplasmic substrate-binding protein (probable substrate ribose);0.39653902914819095;-0.11331563015734991;-0.5378054785773183;-2.7838286094855498;-3.1803676386337405
HELO_3494;0.9854539872029849;0.9309205037930598;2.4038212418111846;1.770567726501674;2.632824045722177;2.570910890097246;0.08433667982019376;0.04856855939788054;0.4120966540668347;0.4520553172979768;0.3555387533194649;0.728346252221984;rbsA;ABC-type transport system ATP-binding protein (probable substrate ribose);COG1129;ABC-type sugar transport system, ATPase component;MglA;HELO_RS13700;G;rbsA; ABC-type transport system ATP-binding protein (probable substrate ribose);7.5.2.7;rbsA;ABC-type transport system ATP-binding protein (probable substrate ribose);0.04018015726464774;-0.06913685967724792;0.024799358330148902;-0.8468232059343106;-0.8870033631989583
HELO_3495;1.4193720450704042;0.8633059588500668;2.095616035734048;1.932166357552421;2.620363000514936;2.085658393368214;0.18644819729378406;0.1995415589390339;0.3563956462247107;0.6242616862694663;0.27024587455298454;0.30461844342411154;rbsC;ABC-type transport system permease protein (probable substrate ribose);COG1172;Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component;AraH;HELO_RS13705;G;rbsC; ABC-type transport system permease protein (probable substrate ribose);;rbsC;ABC-type transport system permease protein (probable substrate ribose);0.37676805310277306;0.004648185047255726;0.23055600522839015;-0.3509457126055673;-0.7277137657083403
HELO_3496;2.1772871622828522;0.9108506560013035;1.8461945805182147;2.05396892864853;3.0281391158311486;2.3719626178606603;0.32537029096406644;0.14259113568576517;0.07275852881203683;0.230303859173492;0.4610996423550951;0.4265836780971111;HELO_3496;carbohydrate kinase domain protein;COG1070;Sugar (pentulose or hexulose) kinase;XylB;HELO_RS13710;G;;rbsC;2.7.1.16;HELO_3496;carbohydrate kinase domain protein;0.733580458515344;-0.2445542471128399;0.25652496671662517;-0.08579305611187937;-0.8193735146272234
HELO_3497;3.5429595513583187;1.2159485204536133;2.7549337071600757;2.42965193525467;3.7537173176766885;2.3312367573851382;0.2805055462319871;0.21131226375634685;0.6225881470263717;0.19205687593530282;0.5340047687204146;0.10246666425710517;HELO_3497;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS13715;I;;;;HELO_3497;probable oxidoreductase (short-chain dehydrogenase family);1.035708094312178;0.17272954462164325;0.512998222445189;0.4475745675295588;-0.5881335267826191
HELO_3498;8.472807969149686;3.6910972041800405;9.118314822047141;9.896795180057094;10.29071861181775;9.018007718788375;0.2216545107620267;0.273374562742048;0.4713243771453541;0.9060507347116249;0.5780235636043006;0.6401798398240555;talA3;transaldolase;COG0176;Transaldolase/fructose-6-phosphate aldolase;TalA;HELO_RS13720;G;talA3; transaldolase;2.2.1.2;talA3;transaldolase;1.0138667435416862;0.014373404790755107;0.1725416828589692;-0.08073158442493877;-1.094598327966625
HELO_3499;111.57459656672863;100.33888104449012;62.30197516293009;66.70293922146031;59.517681295948535;54.96269748452721;1.6610534107697392;4.847513039184153;2.5649095529146595;5.514696319495149;2.837392915699149;4.134176198342584;HELO_3499;LacI family transcription regulator;COG1609;DNA-binding transcriptional regulator, LacI/PurR family;PurR;HELO_RS13725;K;;talA3;;HELO_3499;LacI family transcription regulator;0.15169350327986386;0.17778501145494197;0.11289120828318744;1.0083438981874524;0.8566503949075885
HELO_3500;223.46732817462552;158.26193813819376;108.77556373808277;121.71529169716786;107.41738532638601;113.2639467184351;11.205286106413915;9.597487836517553;1.489767058503074;7.100383155130235;2.976736899413272;2.5563902604976843;cbbP;phosphoribulokinase;COG3954;Phosphoribulokinase;PrkB;HELO_RS13730;G;cbbP; phosphoribulokinase;2.7.1.19;cbbP;phosphoribulokinase;0.4951039523735936;-0.05781332385292348;-0.07577414775015878;0.9741352049820575;0.4790312526084639
HELO_3501;291.50084142190144;213.95162506168845;140.70310062378744;142.43900081971324;132.54628427331735;140.72208252374082;9.886286935750947;9.82050160080291;13.589125935217728;4.277408603879574;17.219990356669733;12.141626320379585;HELO_3501;thioesterase domain protein;COG0824;Acyl-CoA thioesterase FadM;FadM;HELO_RS13735;I;;cbbP;3.1.2.-;HELO_3501;thioesterase domain protein;0.44442875750665056;-0.00019324389361763394;-0.08572473460261243;1.045376204536681;0.6009474470300304
HELO_3502;584.5034421777644;505.01089235585397;720.5778370693783;763.232428505054;665.2547521664177;688.344366352037;5.650956483409685;36.381060381408595;25.552988487094606;6.06860438644578;28.786719472705386;10.84981731586853;purD;phosphoribosylamine--glycine ligase;COG0151;Phosphoribosylamine-glycine ligase;PurD;HELO_RS13740;F;purD; phosphoribosylamine--glycine ligase;6.3.4.13;purD;phosphoribosylamine--glycine ligase;0.2105092117544327;0.06593015709270489;-0.04915095231102384;-0.23554721810494783;-0.44605642985938054
HELO_3503;177.49004064382174;145.86124265238695;209.3825267203034;251.34354195514456;177.61761208295806;188.26748460825874;8.000830384477217;1.4182397377330485;21.821710799318577;35.15591759168672;15.43146553504486;3.122448397861525;HELO_3503;PhaR family transcription regulator;COG5394;Polyhydroxyalkanoate (PHA) synthesis regulator protein, binds DNA and PHA;;HELO_RS13745;TQ;;purD;;HELO_3503;PhaR family transcription regulator;0.2813898648902402;0.15258830372068122;-0.08355224280527906;-0.08458300587644185;-0.36597287076668206
HELO_3504;97.21235003194407;57.367712488455375;64.73059113951416;69.16753617324844;65.67795466709822;61.35446969707565;2.424446949180934;0.6186357333970182;3.3935794101396626;7.869895939700261;5.391259903837314;5.5669338932379215;HELO_3504;RsmE family protein;COG1385;16S rRNA U1498 N3-methylase RsmE;RsmE;HELO_RS13750;J;;;2.1.1.193;HELO_3504;RsmE family protein;0.7507339242257434;0.07607198067805054;0.09671687150208452;0.6554114732161223;-0.09532245100962111
HELO_3505;372.4949317761425;97.39359040751849;288.96914977469004;347.15746889339334;235.20012915054693;250.91832303111937;25.286542688378493;4.511859849823114;19.47144167178098;22.379584830547493;18.51441732394513;19.641620645934502;HELO_3505;peptidase domain protein;COG4067;Uncharacterized conserved protein;;HELO_RS13755;S;;;;HELO_3505;peptidase domain protein;1.9244524230189857;0.20294335916060469;-0.0929463053129389;0.5681326072796704;-1.3563198157393153
HELO_3506;320.1544366166151;91.87068006504626;255.97213939564017;260.20109854171847;214.25949299535492;260.7758926387566;17.11491267613752;4.7084070055102405;24.747242466705732;13.386118941085773;24.788291577969133;24.032184132577335;HELO_3506;MltB family protein;COG3409;Peptidoglycan-binding (PGRP) domain of peptidoglycan hydrolases;PGRP;HELO_RS13760;M;;;4.2.2.-;HELO_3506;MltB family protein;1.7899721223154108;-0.02672029063350756;-0.28225538108037185;0.29493498351826375;-1.495037138797147
HELO_3507;56.59807096214944;15.407557145037257;9.53911852339207;12.777510532066145;15.073382000324024;11.144497174743774;7.999299109995125;0.6994997596440827;2.1201842431569786;1.5263253088078996;2.5705843033156275;1.1885889921757753;mrpG1;Mrp-type sodium/proton antiporter system subunit G;COG1320;Multisubunit Na+/H+ antiporter, MnhG subunit;MnhG;HELO_RS13765;P;mrpG1; Mrp-type sodium/proton antiporter system subunit G;;mrpG1;Mrp-type sodium/proton antiporter system subunit G;1.8116600368564546;-0.2045485514213663;0.40437075989957894;2.245717736135896;0.4340576992794416
HELO_3508;36.757814421372345;11.09723928312062;3.43870371031643;3.6310890891234577;4.117810639950565;3.5301199673380155;5.288080468422858;1.0621039971851025;1.56792134361776;1.2500176723375003;1.3460057871531002;1.161299740277302;mrpF1;Mrp-type sodium/proton antiporter system subunit F;COG2212;Multisubunit Na+/H+ antiporter, MnhF subunit;MnhF;HELO_RS13770;P;mrpF1; Mrp-type sodium/proton antiporter system subunit F;;mrpF1;Mrp-type sodium/proton antiporter system subunit F;1.6420974110316808;-0.029410846486414233;0.17597751190000865;3.0591540963910497;1.417056685359369
HELO_3509;33.88559552412338;8.791789411891306;11.523824304788823;15.379304511157992;19.720276274585625;13.700947449730714;2.9706480218812743;1.2505708191062161;0.8578734801220057;1.0457893457203478;2.211921450899323;2.4268497947917647;mrpE1;Mrp-type sodium/proton antiporter system subunit E;COG1863;Multisubunit Na+/H+ antiporter, MnhE subunit;MnhE;HELO_RS13775;P;mrpE1; Mrp-type sodium/proton antiporter system subunit E;;mrpE1;Mrp-type sodium/proton antiporter system subunit E;1.8329870257635008;-0.2312339628316029;0.49513410221232323;1.2467223246044696;-0.5862647011590312
HELO_3510;22.99805180107928;5.71801727160128;9.603342933697634;12.850660537376202;11.446053016584878;8.569118279519754;0.8704430723029887;0.41019113778500993;1.6251415957627815;2.081919220472909;0.5014196668215102;1.6660694344327924;mrpD1;Mrp-type sodium/proton antiporter system subunit D;COG0651;Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit;HyfB;HELO_RS13780;CP;mrpD1; Mrp-type sodium/proton antiporter system subunit D;;mrpD1;Mrp-type sodium/proton antiporter system subunit D;1.836809880606912;0.14806127466443275;0.37923039409267867;1.326459387653443;-0.510350492953469
HELO_3511;28.650939913871024;9.234711617379142;7.548096413965292;8.948618141877882;8.556738687728199;7.385554005910591;4.18120103687418;1.0007158981428432;1.232947718277322;2.017665566185118;3.3803156032766952;0.8403399721671007;mrpC1;Mrp-type sodium/proton antiporter system subunit C;COG1006;Multisubunit Na+/H+ antiporter, MnhC subunit;MnhC;HELO_RS13785;P;mrpC1; Mrp-type sodium/proton antiporter system subunit C;;mrpC1;Mrp-type sodium/proton antiporter system subunit C;1.534607385675403;0.027697079200587282;0.18861227011479675;1.8220998317543255;0.28749244607892255
HELO_3512;23.19418655134439;5.120144350485625;4.388643371251416;4.750160707839144;4.929050969107264;5.270735277257596;1.495532778049162;0.14856271247516653;0.8820988942784215;0.43093321012918356;0.9984078778352157;0.7128408076659919;mrpB1;Mrp-type sodium/proton antiporter system subunit B;;;;;;;;;mrpB1;Mrp-type sodium/proton antiporter system subunit B;1.9830228482149832;-0.21871250655828556;-0.08083341774328812;1.9479539124615788;-0.03506893575340442
HELO_3513;39.7445262281815;15.496524482245514;27.119237449158106;24.961043368943276;22.74319937714637;27.163607852885374;0.8375534201870859;1.5002331370064501;1.8754819191408827;2.867663718458788;1.375907848193103;1.4004303367669324;mrpA1;Mrp-type sodium/proton antiporter system subunit A;COG2111;Multisubunit Na+/H+ antiporter, MnhB subunit;MnhB;HELO_RS13795;P;mrpA1; Mrp-type sodium/proton antiporter system subunit A;;mrpA1;Mrp-type sodium/proton antiporter system subunit A;1.3044441484497789;-0.0022746886493463236;-0.2463178098177945;0.5327740954212397;-0.7716700530285392
HELO_3514;79.62959686930924;84.41352355499431;85.36852622161835;106.48709570428656;71.6661688157945;88.97452032384537;3.318243560698018;2.8144860783731493;1.7513578897851168;1.470984351260381;1.7644909324468003;3.7755073382953315;mrpAB2;Mrp-type sodium/proton antiporter system subunit AB;COG2111;Multisubunit Na+/H+ antiporter, MnhB subunit;MnhB;HELO_RS13800;P;mrpAB2; Mrp-type sodium/proton antiporter system subunit AB;;mrpAB2;Mrp-type sodium/proton antiporter system subunit AB;-0.08315500141261367;-0.05901083388997641;-0.30823266080895895;-0.15820699684941442;-0.07505199543680074
HELO_3515;52.839508429636545;49.24928832218177;19.177559258373055;21.98519184128212;25.003401128887386;22.16622932231209;4.997927401856805;4.239775447564083;5.2378447564715;3.2698680473334085;3.5924303810768237;4.812158521106637;mrpC2;Mrp-type sodium/proton antiporter system subunit C;COG1006;Multisubunit Na+/H+ antiporter, MnhC subunit;MnhC;HELO_RS13805;P;mrpC2; Mrp-type sodium/proton antiporter system subunit C;;mrpC2;Mrp-type sodium/proton antiporter system subunit C;0.09956207415495211;-0.19927156938463053;0.16667709226137983;1.2166419963727337;1.1170799222177816
HELO_3516;99.73273632670045;99.47033443071591;109.01381028732965;122.22237529310034;119.80447936593141;110.86148742198698;4.600842157235014;1.028199053688686;5.205000917787882;4.987650897507139;4.738778843586203;2.916856234188961;mrpD2;Mrp-type sodium/proton antiporter system subunit D;COG0651;Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit;HyfB;HELO_RS13810;CP;mrpD2; Mrp-type sodium/proton antiporter system subunit D;;mrpD2;Mrp-type sodium/proton antiporter system subunit D;0.0037630253580038797;-0.024028779123004718;0.11096053094373026;-0.15118080960367042;-0.1549438349616743
HELO_3517;53.66537690681091;49.42260064436052;35.53700475914285;40.1590952998235;45.30025460973625;41.611603217561985;2.1671523952328635;5.578680892572175;5.274693229347476;5.467041955161915;1.2645576903765736;5.323311703509082;mrpE2;Mrp-type sodium/proton antiporter system subunit E;COG1863;Multisubunit Na+/H+ antiporter, MnhE subunit;MnhE;HELO_RS13815;P;mrpE2; Mrp-type sodium/proton antiporter system subunit E;;mrpE2;Mrp-type sodium/proton antiporter system subunit E;0.11655684092431873;-0.22188796329528326;0.11977379458364101;0.35938103841324764;0.24282419748892892
HELO_3518;149.86619355785868;191.9879924676393;33.189523440456384;33.421289782932696;39.170793194115;38.04340328785676;5.925834981956545;16.497636897586535;12.242860491149292;10.877179835717929;8.873005736800325;9.170650598626956;mrpF2;Mrp-type sodium/proton antiporter system subunit F;COG2212;Multisubunit Na+/H+ antiporter, MnhF subunit;MnhF;HELO_RS13820;P;mrpF2; Mrp-type sodium/proton antiporter system subunit F;;mrpF2;Mrp-type sodium/proton antiporter system subunit F;-0.35524152747832094;-0.19152449993502874;0.04106813499393436;1.950118841091573;2.305360368569894
HELO_3519;87.49770739384043;99.81263701942827;109.99217991239622;121.79330019793167;139.8407773590812;113.26630689510536;6.769569007614951;5.579005076207712;7.8795737002619255;5.533242451119966;7.039312678201442;3.0572745996352784;mrpG2;Mrp-type sodium/proton antiporter system subunit G;COG1320;Multisubunit Na+/H+ antiporter, MnhG subunit;MnhG;HELO_RS13825;P;mrpG2; Mrp-type sodium/proton antiporter system subunit G;;mrpG2;Mrp-type sodium/proton antiporter system subunit G;-0.18796450763377415;-0.04194203301858934;0.3016650288128382;-0.3686880797729035;-0.18072357213912937
HELO_3520;69.94332678363105;52.812643548920356;80.26344614181392;87.45995447489692;112.29605084542219;81.29391320332064;1.3539457978885048;2.5738704718528393;8.316400790400769;7.698523218112386;19.031475408575584;6.258255595362024;hemH;ferrochelatase;COG0276;Protoheme ferro-lyase (ferrochelatase);HemH;HELO_RS13830;H;hemH; ferrochelatase;4.99.1.1,4.99.1.9;hemH;ferrochelatase;0.3987218039322844;-0.018179180641682002;0.46123994204866037;-0.21411874199226855;-0.612840545924553
HELO_3521;208.34011958590978;198.1579193736003;136.82317079539015;89.52874460578887;88.88374692227092;111.0446176264353;11.781094309999405;12.835594543577104;13.292122257671437;17.427463681042962;10.08764444274135;11.460617990434566;HELO_3521;uncharacterized protein;;;;;;;;;HELO_3521;uncharacterized protein;0.0719359789192211;0.29874510728500603;-0.3179411751351102;0.9017754808479994;0.8298395019287783
HELO_3522;143.47487181452797;132.0900978430167;173.19799970967082;224.02967241546756;143.15685628730316;169.5413073606667;3.7148750133738897;4.153200949741907;6.930506028915872;9.334080028033565;2.3145354497780954;6.156015079663232;dnaB1;replicative DNA helicase;COG0305;Replicative DNA helicase;DnaB;HELO_RS13845;L;dnaB1; replicative DNA helicase;3.6.4.12;dnaB1;replicative DNA helicase;0.11841535389994817;0.030606836374775348;-0.24248176648510178;-0.239302631518016;-0.3577179854179642
HELO_3523;4441.706083518879;3203.9471162325444;1986.6764139043155;1415.275319533562;1537.8294589386176;1964.8048479161491;91.33067191329206;142.0154478193696;124.32555348337645;160.36036470735678;46.3483272943599;218.83781680984876;rplI;50S ribosomal protein L9;COG0359;Ribosomal protein L9;RplI;HELO_RS13850;J;rplI; 50S ribosomal protein L9;;rplI;50S ribosomal protein L9;0.47113814839851464;0.01596280321728827;-0.35328675400115017;1.1763185924276556;0.7051804440291409
HELO_3524;2695.667293602631;2028.3506051662578;1727.9105139676465;1391.9982514735773;1420.3714460915342;1749.7406484468993;73.16959213291032;158.7559306999618;118.40892403492906;162.58134883571427;33.11185864164917;145.00208671503572;HELO_3524;uncharacterized protein;;;;;;;;;HELO_3524;uncharacterized protein;0.41015940036844967;-0.01810218236606076;-0.30068175894064453;0.6232121559739046;0.2130527556054549
HELO_3525;10549.936608729184;13047.359014498803;2114.599737554334;1675.4885021402117;1880.0271994662446;2750.6555818933616;1417.1920301005955;866.1106336410909;775.3212333577766;290.95915359013065;930.6958057114822;778.8609740601468;rpsR;30S ribosomal protein S18;COG0238;Ribosomal protein S18;RpsR;HELO_RS13860;J;rpsR; 30S ribosomal protein S18;;rpsR;30S ribosomal protein S18;-0.3064973092941674;-0.3792332011524877;-0.5487791924355481;1.9389992651542496;2.245496574448417
HELO_3526;2741.4037541434286;2984.1523910051656;3166.727849934898;2748.6364809065612;2534.5495138139263;2953.442924649334;107.51739000573096;326.5646254251785;190.45547108577847;139.53251610924863;53.1774598627003;78.80396816241955;rpsF;30S ribosomal protein S6;COG0360;Ribosomal protein S6;RpsF;HELO_RS13865;J;rpsF; 30S ribosomal protein S6;;rpsF;30S ribosomal protein S6;-0.12236359295192933;0.10056226549468228;-0.22058768110149352;-0.10744513899915198;0.014918453952777355
HELO_3527;308.5631523485856;309.2888430014511;283.06198838597646;311.6566453287403;276.5016797518404;290.64709261152626;12.262000675561971;15.566279080507435;28.58231848130501;14.881820896126486;23.46559150820623;12.920500773054705;rlmB;23S rRNA (guanosine-2'-O-)-methyltransferase RlmB;COG0566;tRNA G18 (ribose-2'-O)-methylase SpoU;SpoU;HELO_RS13870;J;rlmB; 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB;2.1.1.185;rlmB;23S rRNA (guanosine-2'-O-)-methyltransferase RlmB;-0.003378066997596463;-0.038017901279301825;-0.07172718790133992;0.08601006388157906;0.08938813087917552
HELO_3528;247.71954207890113;362.1941467592778;452.8420738858445;494.96091055158985;435.3995103725836;474.45528398345044;4.300020354240849;9.13097148439972;39.54657896125498;12.983729596031614;36.9545469555777;16.536442076234575;rnr;ribonuclease R;COG0557;Exoribonuclease R;VacB;HELO_RS13875;K;rnr; ribonuclease R;3.1.13.1;rnr;ribonuclease R;-0.5462210866999664;-0.0671193019702816;-0.12366018067399054;-0.9347897980473823;-0.3885687113474159
HELO_3529;120.90423099407344;172.23204754175467;85.80289496377935;159.42091203006933;80.55302297499333;81.55554489888512;9.07090750501027;14.300164487243954;2.7138397584947143;4.538055316449343;4.187308419699951;6.093696483741806;HELO_3529;probable endonuclease;COG1864;DNA/RNA endonuclease G, NUC1;NUC1;HELO_RS13895;F;;;;HELO_3529;probable endonuclease;-0.5069576509140115;0.07237804082271104;-0.017626762805025287;0.5623111761089508;1.0692688270229622
HELO_3530;144.72261104857833;129.08666817916423;199.26022384534608;347.6805103799366;188.06383245127532;181.15982918904967;20.10772179177089;25.763127080022976;17.177058182219685;45.53588782061415;19.5388964085636;11.420180963056053;HELO_3530;AsnC_Cterm domain protein;COG1522;DNA-binding transcriptional regulator, Lrp family;Lrp;HELO_RS13900;K;;;;HELO_3530;AsnC_Cterm domain protein;0.16375163427875083;0.13667105436170068;0.053668561111007484;-0.3219800932312964;-0.48573172751004723
HELO_3531;17.472634420212852;3.5331034745310297;6.832967006013729;14.934989133564338;12.729368701026141;6.619096307899817;0.4918645581011489;0.2525679430504357;1.0775223751637981;1.1225887790193716;1.6301229696003214;1.0638989700456376;ycgB;YcgB family protein;COG2719;Stage V sporulation protein SpoVR/YcgB, involved in spore cortex formation (function unknown);SpoVR;HELO_RS13905;D;ycgB; YcgB family protein;;ycgB;YcgB family protein;2.02681862840837;0.039938989976906925;0.849573492909939;1.27769783007873;-0.7491207983296397
HELO_3532;29.347874183139442;5.323389592731341;11.568266517893372;27.311767861858794;20.877241427452862;10.615259253430956;2.4822896790734434;0.3334684176681903;1.4736566323831652;2.506031661392569;2.478660083177378;0.7931789224737599;HELO_3532;UPF0229 family protein;COG2718;Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family;YeaH;HELO_RS13910;R;;ycgB;;HELO_3532;UPF0229 family protein;2.262825447902715;0.11376432374874712;0.9134094799229118;1.3855741061273532;-0.8772513417753616
HELO_3533;49.45794947358862;8.717107198166905;27.807580308015776;75.9866601120154;42.72140941765698;23.531736962790017;2.5997327560887307;0.5188423454016791;3.3238077755846676;7.297340614212804;5.9578511739776365;1.2314520753855203;HELO_3533;PrkA family protein;COG2766;Predicted Ser/Thr protein kinase;PrkA;HELO_RS13915;T;;;;HELO_3533;PrkA family protein;2.3764827890755815;0.23179909932119713;0.8336905218169379;1.040432191667663;-1.3360505974079184
HELO_3534;21.454175529853313;6.115484767756573;17.56782981343245;29.33482400708263;23.533038620021014;15.589009680086312;1.2536409728960989;0.18879322005533222;1.4324360301167405;2.0979054373385533;2.306311184781956;1.2638579906536842;fadH;2%2C4-dienoyl-CoA reductase (NADPH);COG1902;2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family;FadH;HELO_RS13920;C;fadH; 2,4-dienoyl-CoA reductase (NADPH);1.3.1.34;fadH;2%2C4-dienoyl-CoA reductase (NADPH);1.6579497964058132;0.16257744079766745;0.5644981708981716;0.43675598656546555;-1.2211938098403476
HELO_3535;39.6981559420473;23.66379996189011;61.67108197901242;55.277567814119955;62.801192001207085;60.869631969288754;2.696732086971578;1.6265938360930297;7.010156515643657;0.8487892379884026;4.14742521110636;5.673190512305848;HELO_3535;alpha/beta hydrolase fold protein;COG3571;Predicted hydrolase of the alpha/beta-hydrolase fold;;HELO_RS13950;R;;;;HELO_3535;alpha/beta hydrolase fold protein;0.7225683331024149;0.0185684484901536;0.0443519260692149;-0.6042680255327522;-1.326836358635167
HELO_3536;15.536449919054624;6.545682726913918;11.839893584038116;7.738172457566339;8.776744073194335;12.454044085483615;0.19428992324950214;0.1428389018753646;1.4842230011687396;0.39597765426911763;0.23827420368706437;0.7924529541186225;ccoN;cbb3-type cytochrome c oxidase subunit CcoN;COG3278;Cbb3-type cytochrome oxidase, subunit 1;CcoN;HELO_RS13955;C;ccoN; cbb3-type cytochrome c oxidase subunit CcoN;7.1.1.9;ccoN;cbb3-type cytochrome c oxidase subunit CcoN;1.131926201266244;-0.06740664506050997;-0.46061389780224893;0.29760965621413105;-0.8343165450521131
HELO_3537;9.642388332639644;5.739351114415388;6.214509138380552;4.713844386394295;5.810811472063272;7.20580543922863;0.2916118433422479;0.4347423084841372;0.404828975450653;0.19887158248761186;0.5935939306811111;0.37542116818794946;ccoO;cbb3-type cytochrome c oxidase subunit CcoO;COG2993;Cbb3-type cytochrome oxidase, cytochrome c subunit FixO;CcoO;HELO_RS13960;C;ccoO; cbb3-type cytochrome c oxidase subunit CcoO;;ccoO;cbb3-type cytochrome c oxidase subunit CcoO;0.6591403563738876;-0.18574370833778886;-0.2688182501985752;0.37510509918504376;-0.2840352571888438
HELO_3538;10.858848408408596;4.854503673235361;1.6659429679985462;0.5355575245045759;1.0488427338375022;1.3322090806859361;3.495569881063443;0.6341994884425506;1.6537742975719898;0.3842327109137249;0.1534931974521799;0.6376447978797144;ccoQ;cbb3-type cytochrome c oxidase subunit CcoQ;COG4736;Cbb3-type cytochrome oxidase, subunit 3;CcoQ;HELO_RS13965;C;ccoQ; cbb3-type cytochrome c oxidase subunit CcoQ;;ccoQ;cbb3-type cytochrome c oxidase subunit CcoQ;1.01834514535941;0.19294878666430004;-0.18688788135298973;2.34619488323691;1.3278497378775
HELO_3539;12.965174262790093;6.498202203570275;9.48381001171074;7.415404494794589;7.4889056877242455;10.148772364385552;0.15002413927959274;0.3445339324484151;1.0216795674560057;0.5177812361894755;0.5958102014411127;1.3603527812418579;ccoP;cbb3-type cytochrome c oxidase subunit CcoP;COG2863;Cytochrome c553;CytC553;HELO_RS13970;C;ccoP; cbb3-type cytochrome c oxidase subunit CcoP;;ccoP;cbb3-type cytochrome c oxidase subunit CcoP;0.8972169398970551;-0.08872174360699026;-0.3932343662146365;0.32494871822198146;-0.5722682216750736
HELO_3540;5.372645048764763;2.6127857773183436;3.2247566508005314;2.37035150515529;2.269013323450639;2.7455702590887525;1.0087093796755517;0.15872213409290103;0.30487761865263374;0.46077330996903765;0.21182956486704896;0.505301934209859;HELO_3540;FixG family protein;COG0348;Polyferredoxin NapH;NapH;HELO_RS13975;C;;ccoP;;HELO_3540;FixG family protein;0.8187805943411637;0.1736828592632218;-0.19633012711233766;0.7667069218352003;-0.0520736725059634
HELO_3541;4.832360698231528;2.231314847915776;2.0991426033146094;1.646829377418592;1.9545399771341618;2.6126192655781613;0.8269007878733617;0.802510742411297;0.757332834268427;0.12152660226815945;0.6205664439929371;0.9874640340050785;HELO_3541;FixH domain protein;COG3198;Uncharacterized conserved protein;;HELO_RS13980;S;;;;HELO_3541;FixH domain protein;0.8519586163148702;-0.22117607663449546;-0.29011169717446994;0.6910347279197842;-0.1609238883950861
HELO_3542;5.80625903116881;2.4989681081206956;3.030110381956945;2.563401516807033;2.977431297225554;3.3473558426775782;0.4718238041109819;0.05620044509413229;0.8146257249156376;0.44128552134275356;0.542003048415563;0.5923534038577665;HELO_3542;P-type transport ATPase;COG2217;Cation-transporting P-type ATPase;ZntA;HELO_RS13985;P;;;7.2.2.9;HELO_3542;P-type transport ATPase;0.9599325431575698;-0.10931883516718877;-0.12830117800728225;0.6467238692425026;-0.31320867391506724
HELO_3543;12.571365531691649;3.823279153021224;8.661376601702644;10.188230319578684;6.180170370049983;8.410455701861213;0.14938286167044357;0.7067150973453917;0.5496612828857421;0.36351379973752596;1.7233034244057652;1.3070966426967425;HELO_3543;uncharacterized protein;COG2836;Uncharacterized membrane protein, DsbD domain;DsbD;HELO_RS13995;S;;;;HELO_3543;uncharacterized protein;1.4924796746827234;0.03796417894230597;-0.3902465107212274;0.5282293976552013;-0.9642502770275221
HELO_3544;130.3273159108289;152.33984519674948;219.11592520565867;277.7666441811814;376.72718603097195;210.62349340323155;0.6960023100968314;3.975514168426583;3.581936469295891;8.419537185013644;16.118146336634624;15.38459376348368;ttcA;tRNA 2-thiocytidine biosynthesis protein TtcA;COG0037;tRNA(Ile)-lysidine synthase TilS/MesJ;TilS;HELO_RS14000;J;ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA;;ttcA;tRNA 2-thiocytidine biosynthesis protein TtcA;-0.2235656023591286;0.05676372952526787;0.8358448248403691;-0.6883327711422087;-0.4647671687830801
HELO_3545;24.789787479138152;9.447851847217196;149.5719511711495;130.28968247470672;847.2111888598865;135.2643006354743;3.362033184212143;1.165468941172422;4.904591796437633;20.32151863738213;36.63534778247886;25.34186849230755;HELO_3545;exonuclease domain protein;COG0847;DNA polymerase III, epsilon subunit or related 3'-5' exonuclease;DnaQ;HELO_RS14005;L;;ttcA;2.7.7.7;HELO_3545;exonuclease domain protein;1.30359354022448;0.14404540159481272;2.6380158683577024;-2.4015358557192465;-3.7051293959437266
HELO_3546;44.051522206693825;12.332533243686866;200.55985508638005;167.01212872213617;732.5205923112289;195.75899260950996;7.341293497688032;1.4336540409228768;24.01707616497367;22.87149657552483;10.05066056842635;30.075731749954134;HELO_3546;DUF294 / CBS domain protein;COG2905;Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains;;HELO_RS14010;T;;;;HELO_3546;DUF294 / CBS domain protein;1.7566249275511807;0.03477875047139012;1.898407893905902;-2.1267818157654776;-3.8834067433166584
HELO_3547;94.75211494212117;38.2739890565941;1267.3966686174529;694.3240515924161;4132.217007070711;1154.1140705003706;27.208362189519526;4.1637269959564485;222.45758109432742;68.93885679781953;1133.7719696578504;181.22302204728396;HELO_3547;DUF4212 domain protein;COG4327;Uncharacterized membrane protein, DUF4212 domain;;HELO_RS14015;S;;;;HELO_3547;DUF4212 domain protein;1.2857302132856603;0.13497066484955944;1.839229783249328;-3.5925871651391033;-4.8783173784247635
HELO_3548;50.16874815417204;15.616715698515025;1083.8603195945088;576.3700619445989;3931.1154596283536;1027.9159099605515;8.58858153896167;2.7863576984827203;30.33586890976642;106.6392285858804;180.29808730195157;65.03627165389065;HELO_3548;SSS family transport protein;COG4147;Na+(or H+)/acetate symporter ActP;ActP;HELO_RS14020;C;;;;HELO_3548;SSS family transport protein;1.6226276772302786;0.07638422131883438;1.9341806043412273;-4.329718331749023;-5.952346008979301
HELO_3549;112.61759628253155;52.0900539524392;202.88430922592104;111.98362118202833;752.2132557318602;218.8050524300304;1.700745740744472;6.832023015606074;9.256492703903668;14.49191382865373;21.09225060135638;4.9356309629493325;HELO_3549;uncharacterized protein;;;;;;;;;HELO_3549;uncharacterized protein;1.0976727737541836;-0.10847379743289753;1.776833841636864;-0.9520382619389114;-2.049711035693095
HELO_3550;279.90550499653233;210.30298954675223;244.74261892769027;347.34404786552295;160.9549735544529;249.6495723294104;11.358191381271343;5.085001916314725;3.373324811943054;16.877792223049827;14.744971382292146;25.309192378258455;HELO_3550;GntR family transcription regulator;COG2186;DNA-binding transcriptional regulator, FadR family;FadR;HELO_RS14030;K;;;;HELO_3550;GntR family transcription regulator;0.41077171881968244;-0.028523687785881435;-0.6300789992846898;0.16441312517989104;-0.2463585936397914
HELO_3551;15.806384281105444;19.391488375179602;29.84912383056162;31.795942640446288;23.143055942948223;34.5011468025775;1.5640505830090152;1.9252325369134038;0.5344832087880714;1.9101739528607262;1.042397565080932;3.0931557522470223;HELO_3551;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS14035;I;;;1.1.1.-;HELO_3551;probable oxidoreductase (short-chain dehydrogenase family);-0.2789577044260412;-0.2026361142380333;-0.5562573302093279;-1.0788562520009757;-0.7998985475749345
HELO_3552;37.00398595619681;56.2695791548284;91.27531137526869;68.84224375415111;91.86115022106254;87.28066542934948;0.5401499153118757;2.411272120274864;5.340946466213671;2.5956915258062443;5.182964781862857;10.548761146487522;HELO_3552;ureidoglycolate lyase;COG0179;2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway);YcgM;HELO_RS14040;Q;;;;HELO_3552;ureidoglycolate lyase;-0.5916182617921111;0.06384719653358228;0.07297764670337958;-1.2159467641247819;-0.6243285023326708
HELO_3553;7.7454935446206115;9.95525158987328;21.125497763539677;14.461294042066392;24.071323269988685;23.830582351951637;0.18236306487341727;0.478347118814929;2.052732114496814;0.7925157093182629;1.7519331673747958;2.7975304650402153;HELO_3553;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);COG1063;Threonine dehydrogenase or related Zn-dependent dehydrogenase;Tdh;HELO_RS14045;ER;;;;HELO_3553;probable oxidoreductase (zinc-containing alcohol dehydrogenase family);-0.3250109076859693;-0.16640818517955758;0.013920046488867577;-1.5055063886098217;-1.1804954809238524
HELO_3554;7.061870537224781;8.164617945950903;16.10847396652419;10.716834000773064;19.38226685158897;17.45731751097921;0.1575404059532736;0.5641796562064118;0.5199121776880193;0.5258110823723041;1.584265004167068;2.3226247131233144;HELO_3554;probable dehydratase (homolog to altronate dehydratase);COG2721;Altronate dehydratase;UxaA;HELO_RS14050;G;;;4.2.1.7;HELO_3554;probable dehydratase (homolog to altronate dehydratase);-0.18496012339640355;-0.10948181379873745;0.14312161788719457;-1.1950063737931398;-1.0100462503967362
HELO_3555;12.98138439044829;16.346987910141454;28.55637050628276;18.34809554975269;35.14959896174593;31.82695514281688;1.3455193252452116;0.9431636000074858;3.601776616717648;1.3142627021047566;7.935568428995473;6.056263478652819;HELO_3555;probable oxidoreductase (homolog to mannitol dehydrogenase);COG0246;Mannitol-1-phosphate/altronate dehydrogenases;MtlD;HELO_RS14055;G;;;1.1.1.58;HELO_3555;probable oxidoreductase (homolog to mannitol dehydrogenase);-0.3111779597244384;-0.15141182044264934;0.13909870297425098;-1.231373720569188;-0.9201957608447495
HELO_3556;24.022004837614528;30.372862401256622;163.72373474777487;140.7092634840835;214.01736923833633;196.41170787345948;3.0767830906053506;3.155665012721673;10.107436734649296;10.672452984222039;20.77858161484264;40.07970631424182;HELO_3556;TRAP transporter substrate-binding protein (probable substrate L-fuconate);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS14060;G;;;;HELO_3556;TRAP transporter substrate-binding protein (probable substrate L-fuconate);-0.3263197768204922;-0.26115910869530623;0.12324565225451689;-2.979938261805927;-2.6536184849854347
HELO_3557;9.923440653967427;10.080837176462706;12.31121090181234;29.239800586284023;24.42869212938514;16.601172979395983;2.165919049206992;0.9472617412120776;3.435707743847639;4.041396105542815;4.915014344004796;0.8873573891735478;HELO_3557;TRAP transporter small transmembrane protein (probable substrate L-fuconate);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS14065;G;;;;HELO_3557;TRAP transporter small transmembrane protein (probable substrate L-fuconate);-0.02063953719547973;-0.4030297591919152;0.5307856856744282;-0.6882442298940639;-0.6676046926985841
HELO_3558;10.749921384783734;7.337937329864897;13.122355446062754;24.781981580551022;19.079051231565288;15.0776803924457;0.6290621193884446;0.8222827701898012;0.43076374656668104;3.723908437116131;2.7593096671221673;2.1052640319565996;HELO_3558;TRAP transporter large transmembrane protein (probable substrate L-fuconate);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS14070;G;;;;HELO_3558;TRAP transporter large transmembrane protein (probable substrate L-fuconate);0.49488867055731145;-0.18707854310694705;0.32063182448440397;-0.4524081725033322;-0.9472968430606437
HELO_3559;24.869995661979374;21.245280298325362;26.143991640650185;26.72168309557664;28.40839503444552;26.445024291449325;0.47091479362429634;0.6370851838122731;1.7147614216651235;1.4412994687683913;1.769986442077197;0.893331310315031;HELO_3559;PAS domain protein / sensor histidine kinase / response regulator;COG2202;PAS domain;PAS;HELO_RS14075;T;;;;HELO_3559;PAS domain protein / sensor histidine kinase / response regulator;0.21778053501258654;-0.01591172537031671;0.09968343493904719;-0.0852648041311932;-0.30304533914377974
HELO_3560;32.06554783373943;8.602225988798814;14.01791281767843;12.888916911121816;16.144751119087644;13.77098883335747;1.7860173085046285;0.19732488799965156;1.2810152222268407;1.366976200398396;3.124734360793062;2.0475484429329196;mntH;divalent metal cation transport protein MntH;COG1914;Mn2+ or Fe2+ transporter, NRAMP family;MntH;HELO_RS14080;P;mntH; divalent metal cation transport protein MntH;;mntH;divalent metal cation transport protein MntH;1.783888009109087;0.02391791218846384;0.215000552085431;1.1625623949766646;-0.6213256141324224
HELO_3561;128.47086035648607;56.59858629692511;30.71427923211601;28.074489529750995;30.131077026921528;31.41218773886302;5.435845927391401;8.806597221612758;4.25292982514049;1.725077961504477;3.649437479548033;5.4089784064838256;mntR;DtxR family transcription regulator MntR;COG1321;Mn-dependent transcriptional regulator MntR, DtxR family;MntR;HELO_RS14085;K;mntR; DtxR family transcription regulator MntR;;mntR;DtxR family transcription regulator MntR;1.168522123495534;-0.0314038475984022;-0.05818091222912347;1.9980191238789775;0.8294970003834434
HELO_3562;368.81477506486505;231.81327436102922;300.7013354928343;296.1190725953843;431.2936017198815;331.9695140344498;32.45326139672443;15.474703713281794;12.971367025566334;13.380092097207555;13.240438388198118;14.93570461102201;HELO_3562;response regulator/HTH domain transcription regulator;COG2197;DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains;CitB;HELO_RS14090;KT;;mntR;;HELO_3562;response regulator/HTH domain transcription regulator;0.6676295463004198;-0.14226901067333664;0.3766213900693991;0.15141277200502046;-0.5162167742953994
HELO_3563;287.8163200105556;300.97099362075056;742.7540452836606;517.8993709348953;1658.2155751947219;760.4860293788264;9.42180861734402;26.144769728171298;51.18461091606683;21.8849278650902;89.29033249407944;67.99020477871053;acsA;acetate--CoA ligase;COG0365;Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase;Acs;HELO_RS14095;I;acsA; acetate--CoA ligase;6.2.1.1;acsA;acetate--CoA ligase;-0.06425770924829344;-0.03399195835909552;1.1236118683959475;-1.398665302285652;-1.3344075930373585
HELO_3564;49.90715739164319;15.315785045628486;30.686546616549986;25.98599564357748;29.2773200779037;32.79974016820955;3.4121523994548273;2.199812113448583;0.7093841125615049;1.9785460552134113;4.943217490988401;2.781360488942675;sprT;SprT family protein;COG3091;Predicted Zn-dependent metalloprotease, SprT family;SprT;HELO_RS14100;R;sprT; SprT family protein;;sprT;SprT family protein;1.6416001037003536;-0.0931417209676777;-0.15877464159878674;0.5908563531101292;-1.0507437505902244
HELO_3565;113.01299076155185;77.06876172097009;94.43234001638329;107.32706582995975;119.6604939499482;94.37349906922022;4.452894912503327;6.1059903211483;4.4147746609896075;4.391742877390208;10.552310146310656;6.708599290071835;HELO_3565;uncharacterized protein;COG3318;Uncharacterized conserved protein YecA, UPF0149 family, contains C-terminal Zn-binding SEC-C motif;YecA;HELO_RS14105;S;;sprT;;HELO_3565;uncharacterized protein;0.5463809241442732;0.0008898002888289014;0.3392930405033514;0.2575378629931979;-0.2888430611510753
HELO_3566;39.10594073274577;13.729823669825889;30.448880983158045;38.585545531997;36.112195521282956;28.145885590120333;1.927015023794196;0.8957459523738552;4.23008043751014;4.063218041024993;4.44789694147909;0.48098323493133593;HELO_3566;phospholipase domain protein;COG1502;Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase;Cls;HELO_RS14110;I;;;2.7.8.-;HELO_3566;phospholipase domain protein;1.4450757931325864;0.10971644569396322;0.3486011137689662;0.4605237149384056;-0.9845520781941808
HELO_3567;46.71742170439077;35.379325789962074;50.313659132263304;49.360648876713036;47.425089045191555;50.101002433533274;2.7264502513807276;0.6901060399506804;1.6023523402050472;3.7122732168462176;3.091500423582762;2.1162605222863067;plsB;glycerol-3-phosphate acyltransferase;COG2937;Glycerol-3-phosphate O-acyltransferase;PlsB;HELO_RS14115;I;plsB; glycerol-3-phosphate acyltransferase;2.3.1.15;plsB;glycerol-3-phosphate acyltransferase;0.3913972865101947;0.00599131415183507;-0.0775968906778699;-0.0988354997726919;-0.4902327862828866
HELO_3568;111.94182327627487;70.78916156611261;68.39106406487183;77.67633556360136;81.25603728160003;67.21620116438122;9.463868844163551;3.583631862629476;1.636399479455065;6.106390066727608;3.1288193570183993;6.1136994729311605;rsmJ;16S rRNA (guanine(1516)-N(2))-methyltransferase RsmJ;;;;;;;;;rsmJ;16S rRNA (guanine(1516)-N(2))-methyltransferase RsmJ;0.6537418733595688;0.024635473477089498;0.2700071549488232;0.7273935055168739;0.07365163215730508
HELO_3569;155.14806733885038;125.5235020801381;188.12536638450615;204.32926984381015;213.52703488841414;189.84566770164813;7.79630203244885;10.706023127541876;8.44085230135311;8.336995483858583;9.078653876717343;13.348079900054955;tsaB;tRNA threonylcarbamoyladenosine biosynthesis protein TsaB;COG1214;tRNA A37 threonylcarbamoyladenosine modification protein TsaB;TsaB;HELO_RS14125;J;tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB;;tsaB;tRNA threonylcarbamoyladenosine biosynthesis protein TsaB;0.3035093187912814;-0.01306355966270445;0.16875303191943836;-0.289491723899161;-0.5930010426904424
HELO_3570;534.7717512119984;517.1596973045977;758.528945667115;567.145823169617;1352.0086295373296;763.7147332205321;25.525561112533758;15.202698725943259;80.34684848258973;52.18294436123911;183.80640821536622;62.216968585934936;adk;adenylate kinase;COG0563;Adenylate kinase or related kinase;Adk;HELO_RS14130;F;adk; adenylate kinase;2.7.4.3;adk;adenylate kinase;0.04822171008101428;-0.009816722819822488;0.8231774660526536;-0.5133031532483674;-0.5615248633293817
HELO_3571;1175.2515320168407;1039.486877186259;1244.359441757463;1038.8689958530454;703.4317187154523;1247.6379248452401;16.762079936897322;48.14356509919122;54.70797431244255;20.126930407632095;42.05788163754855;20.637175687224424;aceF;pyruvate dehydrogenase component E2;COG0508;Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component;AceF;HELO_RS14135;C;aceF; pyruvate dehydrogenase component E2;2.3.1.12;aceF;pyruvate dehydrogenase component E2;0.17693783235285565;-0.003792990385775852;-0.8258234139854661;-0.08615858850613911;-0.26309642085899476
HELO_3572;826.0587352900417;886.2872320200282;1195.6379545441794;1087.423033974632;600.0708404255018;1125.9207234708965;48.302578092179;62.94383693686079;57.97376629975097;16.737667978353603;18.877395430595758;79.95470469091951;aceE;pyruvate dehydrogenase component E1;COG2609;Pyruvate dehydrogenase complex, dehydrogenase (E1) component;AceE;HELO_RS14140;C;aceE; pyruvate dehydrogenase component E1;1.2.4.1;aceE;pyruvate dehydrogenase component E1;-0.10141141938144571;0.08660069924378888;-0.9067790906584623;-0.44632433435869423;-0.3449129149772485
HELO_3573;51.15230005518887;57.66102962680005;42.33092202660958;37.84480248646222;37.23473637299811;38.62254684254517;2.2322745662950214;3.3405002930185828;1.6841544302955824;1.5316330517263008;3.520516589755181;6.871831395089898;ampD;1%2C6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD;COG3023;N-acetyl-anhydromuramyl-L-alanine amidase AmpD;AmpD;HELO_RS14145;M;ampD; 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD;3.5.1.28;ampD;1%2C6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD;-0.169671512869372;0.12907531944740125;-0.05143768940450677;0.3964092646433075;0.5660807775126795
HELO_3574;241.91299204370623;109.97866497136864;231.32156764190026;222.0742875362188;216.69715428066192;226.6941047879111;10.153862645267981;3.0361616853772073;10.83186555010324;16.345455522063034;8.349652259500433;12.729006520375528;nadC;nicotinate-nucleotide pyrophosphorylase (carboxylating);COG0157;Nicotinate-nucleotide pyrophosphorylase;NadC;HELO_RS14150;H;nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating);2.4.2.19;nadC;nicotinate-nucleotide pyrophosphorylase (carboxylating);1.1301573004792163;0.029026154145599392;-0.06477439038383004;0.09334271440312758;-1.0368145860760887
HELO_3575;89.7455452146193;130.0185358034947;127.77907308744723;144.94984764133736;105.89304598218835;122.11743409447554;8.511415428488267;8.217187859437567;11.103640305063998;6.7938172026204455;10.092808656137516;6.865353766103968;HELO_3575;GNAT family acetyltransferase;;;;;;;;;HELO_3575;GNAT family acetyltransferase;-0.5298722043163346;0.06486310133849038;-0.20386706934691023;-0.44013634302446114;0.0897358612918735
HELO_3576;47.139691264314784;24.724136532132633;57.42413678545717;61.44994667023226;60.430694550753884;59.2046350671672;6.3272980942800165;1.470583670492195;8.236183144834575;4.004434368590552;9.967566373545612;1.8021056932780593;trmO;tRNA (adenine(37)-N6)-methyltransferase;COG1720;tRNA (Thr-GGU) A37 N6-methylase;TrmO;HELO_RS14160;J;trmO; tRNA (adenine(37)-N6)-methyltransferase;2.1.1.-;trmO;tRNA (adenine(37)-N6)-methyltransferase;0.9041042375786787;-0.043310048853083316;0.029085132613256626;-0.32264767288681995;-1.2267519104654987
HELO_3577;418.2974704930416;295.90531676708434;560.8134570733823;606.3618038905005;577.4778412501364;537.2586375906362;18.958256075481657;9.324899014759264;25.931785069453667;34.647652663283274;38.83827137003845;22.23158706420788;purC;phosphoribosylaminoimidazole-succinocarboxamide synthase;COG0152;Phosphoribosylaminoimidazole-succinocarboxamide synthase;PurC;HELO_RS14165;F;purC; phosphoribosylaminoimidazole-succinocarboxamide synthase;6.3.2.6;purC;phosphoribosylaminoimidazole-succinocarboxamide synthase;0.49797119852386906;0.06179161571949621;0.10396213164908019;-0.36032543909314185;-0.8582966376170109
HELO_3578;479.88308608504457;347.65365635099323;312.6761697122554;281.32440097991645;284.61775017769645;300.39951469159365;15.060063163393544;22.889645367626326;20.422748426160172;8.503048469926638;2.6222207177979127;14.98072313142898;HELO_3578;beta-lactamase domain protein;COG1235;Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase;PhnP;HELO_RS14170;P;;purC;;HELO_3578;beta-lactamase domain protein;0.4638915724207173;0.05759883644615016;-0.07759145316127736;0.674009089816396;0.21011751739567863
HELO_3579;625.3120310260704;367.19908208902353;464.0500127434149;409.25424939896703;509.02650251679125;462.88280038277344;9.625679094981969;16.480661250772933;16.569616456708655;6.514242253249381;13.496735636371357;27.839916003056064;HELO_3579;uncharacterized protein;COG3317;Outer membrane beta-barrel protein assembly factor BamC;BamC;HELO_RS14175;M;;;;HELO_3579;uncharacterized protein;0.7663955623044618;0.003625520267501514;0.13681186017600133;0.43312123674897585;-0.333274325555486
HELO_3580;591.458193061044;351.450774565646;654.5646493196268;614.2833539516947;700.772666689328;657.2761616566717;19.783154008349968;4.758074591926928;12.2833385651617;9.655694898038648;30.71691433494416;47.693318345562844;dapA;4-hydroxy-tetrahydrodipicolinate synthase;COG0329;4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase;DapA;HELO_RS14180;ME;dapA; 4-hydroxy-tetrahydrodipicolinate synthase;4.3.3.7;dapA;4-hydroxy-tetrahydrodipicolinate synthase;0.7492915775653355;-0.005954893352763335;0.09231080339957742;-0.15197960045442116;-0.9012711780197566
HELO_3581;196.68636016832616;104.16237332206947;263.97186516580274;128.31715095026505;312.24771755953174;267.05883317889226;6.039036387191999;7.3378993462849795;19.896380257870998;3.056563613755401;40.73527866038285;25.5459617268857;bcp;probable peroxiredoxin;COG1225;Peroxiredoxin;Bcp;HELO_RS14185;O;bcp; probable peroxiredoxin;1.11.1.24;bcp;probable peroxiredoxin;0.9105947259709799;-0.01671049434509264;0.22475432143598795;-0.43933634374126473;-1.3499310697122446
HELO_3582;154.7740695232816;47.29083002437778;111.22119315149352;160.97574337283072;103.23723288729434;111.32895156276261;5.42377437097718;2.432148471026172;5.43764457610216;3.3069408947000642;4.263428671155439;5.533916687847641;HELO_3582;UPF0118 family protein;COG0628;Predicted PurR-regulated permease PerM;PerM;HELO_RS14190;R;;bcp;;HELO_3582;UPF0118 family protein;1.6896339334319572;-0.001384657646813281;-0.10785912327165015;0.47172528477280373;-1.2179086486591535
HELO_3583;42.95924643682387;22.376474891599074;36.79050226845172;34.29307421725891;44.77853661590654;35.59521398062893;1.8268122162888585;1.5923323773471898;2.7718444009483436;3.3329683346361088;4.362729190950579;3.2171496428873905;bepA;beta-barrel assembly-enhancing protease;COG4783;Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains;BepA;HELO_RS14200;MO;bepA; beta-barrel assembly-enhancing protease;3.4.-.-;bepA;beta-barrel assembly-enhancing protease;0.9111092635590348;0.04636871203639803;0.32301636422431645;0.26451167401522735;-0.6465975895438074
HELO_3584;97.74173075343242;68.53566601566804;89.20598974642087;162.42889767679387;85.85235630255953;87.9748199278253;6.243248593156763;0.7108117480164817;5.271023421744119;8.313875303967118;9.742452185919058;12.16595734331142;lon2;ATP-dependent protease Lon;COG0466;ATP-dependent Lon protease, bacterial type;Lon;HELO_RS14205;O;lon2; ATP-dependent protease Lon;3.4.21.53;lon2;ATP-dependent protease Lon;0.5059067826914418;0.01982612477896062;-0.03483211817972354;0.15026282504990185;-0.35564395764154
HELO_3585;118.0023447391638;121.04253626574875;115.20194501041436;117.38737095112721;106.29819983658939;112.40876765705211;4.684117388368794;3.883277767048603;4.14360635417375;6.053476045700874;3.505074005430047;4.025056264248121;HELO_3585;DUF945 domain protein;;;;;;;;;HELO_3585;DUF945 domain protein;-0.03639406749651286;0.03510203738422657;-0.079906307752732;0.06945782000341083;0.10585188749992369
HELO_3586;135.04694272776388;128.60027436978723;97.73168585802149;105.52149478437964;86.11872366640053;96.10172605398958;3.854191515904492;6.344082022647958;3.4920284643381305;6.521712558185619;4.414702904698021;4.678570450904664;pgpA1;phosphatidylglycerophosphatase PgpA;COG1267;Phosphatidylglycerophosphatase A;PgpA;HELO_RS14215;I;pgpA1; phosphatidylglycerophosphatase PgpA;3.1.3.27;pgpA1;phosphatidylglycerophosphatase PgpA;0.07003576396216626;0.02401622079442589;-0.1565141228350777;0.486535690498763;0.41649992653659673
HELO_3587;388.8684305053082;318.69052876175505;315.9424369201965;310.09075461690605;336.04825066171014;303.31184420076914;15.047929698628714;11.492044908799668;6.932767670215689;4.636552866030772;9.384794292525568;8.640030307533562;thiL;thiamine-monophosphate kinase;COG0611;Thiamine monophosphate kinase;ThiL;HELO_RS14220;H;thiL; thiamine-monophosphate kinase;2.7.4.16;thiL;thiamine-monophosphate kinase;0.2863113345323569;0.058670355452383305;0.14740465096766897;0.3574368511538726;0.07112551662151567
HELO_3588;275.109411320548;221.91168224363165;161.70290190985432;156.1741548098042;175.54820897901607;169.06344764373134;8.562331072247439;2.424752236626941;15.69428415934193;14.821187732701897;15.558178510846174;18.217938619692234;nusB;transcription elongation factor NusB;COG0781;Transcription antitermination protein NusB;NusB;HELO_RS14225;K;nusB; transcription elongation factor NusB;;nusB;transcription elongation factor NusB;0.30876783709340305;-0.06383310799540887;0.05398909490574244;0.6991669730904162;0.39039913599701315
HELO_3589;183.77359672721198;158.55923285373254;310.56213895057516;294.03660068779345;333.87567500317147;327.16015555423934;1.6667770145081515;9.417356656595508;33.571453754876906;36.25881572745389;20.215209482698295;37.78919546072373;ribH1;6%2C7-dimethyl-8-ribityllumazine synthase;COG0054;6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain);RibE;HELO_RS14230;H;ribH1; 6,7-dimethyl-8-ribityllumazine synthase;2.5.1.78;ribH1;6%2C7-dimethyl-8-ribityllumazine synthase;0.21166652497805494;-0.07488015313098018;0.029225503290485122;-0.828641463609813;-1.0403079885878679
HELO_3590;193.74782064468135;242.88624116550227;399.87744031059793;442.23295829674953;388.5425250837613;388.1571388406881;4.396110020704054;6.600950413344271;17.545040093189307;17.45906444824307;28.906317915987017;10.680341018890184;ribB;3%2C4-dihydroxy-2-butanone 4-phosphate synthase;COG0807;GTP cyclohydrolase II;RibA;HELO_RS14235;H;ribB; 3,4-dihydroxy-2-butanone 4-phosphate synthase;4.1.99.12,3.5.4.25;ribB;3%2C4-dihydroxy-2-butanone 4-phosphate synthase;-0.32460118715777053;0.04280840829808419;0.0014280084938036453;-0.9987456390132845;-0.674144451855514
HELO_3591;269.5707967030978;253.54909758643385;264.35905371558187;251.6963734819677;292.75524838720264;252.956110012015;8.922556571427345;17.481079239203947;15.103681315728608;4.826783446789711;11.923100523847864;4.158261339935589;ribD;diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase RibD;COG1985;Pyrimidine reductase, riboflavin biosynthesis;RibD;HELO_RS14240;H;ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase RibD;3.5.4.26,1.1.1.193;ribD;diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase RibD;0.08806218344398076;0.06336658788305005;0.2100354432254461;0.09142694985318212;0.0033647664092013585
HELO_3592;173.3089352364093;167.06522081266473;167.73807778487495;177.08623230665532;170.45803027842726;174.9275421591132;3.1151407461704306;5.405820816117334;3.5627547954167174;9.976348978642731;2.979648254035785;13.229162827873806;nrdR;NrdR family transcription regulator NrdR;COG1327;Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains;NrdR;HELO_RS14245;K;nrdR; NrdR family transcription regulator NrdR;;nrdR;NrdR family transcription regulator NrdR;0.05262531911594692;-0.06019578823800753;-0.03712588533192562;-0.013334834925510464;-0.06596015404145739
HELO_3593;162.24753688703547;240.15328627585495;275.9212085314998;107.16847191373608;231.37449851059043;277.500953253122;4.113153773775484;15.871487856982412;10.894988193309219;4.261772971623421;11.83901705103482;12.565544892653321;galE1;UDP-glucose 4-epimerase;COG1087;UDP-glucose 4-epimerase;GalE;HELO_RS14250;M;galE1; UDP-glucose 4-epimerase;5.1.3.2;galE1;UDP-glucose 4-epimerase;-0.562889246066284;-0.008206716181826224;-0.2612305139751454;-0.7706210413791101;-0.20773179531282615
HELO_3594;110.89262923548625;215.9778559389547;156.62797072798833;58.971075864047215;106.19727421763444;155.471705527949;3.1665695924075794;17.381926319672964;6.439924913035954;0.290265085296739;7.831796739773793;21.596926464719647;HELO_3594;sugar transferase domain protein;COG2148;Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid);WcaJ;HELO_RS14255;M;;galE1;;HELO_3594;sugar transferase domain protein;-0.955432809370949;0.010621759468990355;-0.545633579208304;-0.48378679702069327;0.4716460123502557
HELO_3595;79.95640367409528;162.14806501357296;131.0886821155678;42.79909602785225;107.52543122170717;125.77934632151145;6.452732376677094;14.85593759993738;13.680194150021935;0.5746005166055035;5.611445183484629;8.010822556054412;HELO_3595;glycosyltransferase domain protein;COG1216;Glycosyltransferase, GT2 family;WcaE;HELO_RS14260;G;;;;HELO_3595;glycosyltransferase domain protein;-1.0109647689886598;0.059187121479961746;-0.22428657944613217;-0.6471026268087048;0.36386214217995505
HELO_3596;335.3894564557929;750.4203407255976;735.0586049582886;144.29761685882508;571.0991185737909;667.6955940529107;14.732377987620543;26.224355895369065;76.2745812557403;8.516251815096657;35.03326960147324;62.443652107550605;rfbD;UDP-galactopyranose mutase;COG0562;UDP-galactopyranose mutase;Glf;HELO_RS14265;M;rfbD; UDP-galactopyranose mutase;5.4.99.9;rfbD;UDP-galactopyranose mutase;-1.1594876823075335;0.13847102655722843;-0.22508448999206365;-0.9912171240954617;0.16827055821207182
HELO_3597;119.69294310759803;295.7792324156995;300.21964333478945;185.71419661094;203.1380487096183;306.25936631239216;0.893301743218898;18.632841661901907;22.58106121163211;5.653755723799504;18.339678479173557;10.631897888257287;HELO_3597;ABC-type transport system permease protein;COG4783;Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains;BepA;HELO_RS14285;MO;;;;HELO_3597;ABC-type transport system permease protein;-1.2980488162147115;-0.028641134466994345;-0.589911882274615;-1.3481156650621688;-0.05006684884745738
HELO_3598;458.8163244126419;885.9463405654923;1570.1436291260682;949.0153723500025;1075.1594462404992;1520.299998478428;21.19264046058655;19.800489830219654;205.56051090381908;48.1433439232903;157.80345422664504;168.47841343902886;glyA1;glycine hydroxymethyltransferase;COG0112;Glycine/serine hydroxymethyltransferase;GlyA;HELO_RS14290;E;glyA1; glycine hydroxymethyltransferase;2.1.2.1;glyA1;glycine hydroxymethyltransferase;-0.9477891398818503;0.04651039461598572;-0.49941283207319564;-1.726175088115781;-0.7783859482339306
HELO_3599;31.956530994428217;9.232906074667701;76.42029259609282;80.91410779057485;66.79895661473891;70.28026630755802;3.705688312686115;0.9950150915115386;4.42094041091437;4.2043407852879255;12.276142646105889;10.421466074960941;HELO_3599;uncharacterized protein;;;;;;;;;HELO_3599;uncharacterized protein;1.6873484736815252;0.1192090331780431;-0.0722396555478797;-1.1129383344854498;-2.800286808166975
HELO_3600;59.39044085052663;12.781639106999796;22.14556044846888;26.92493506227035;27.57448705205715;19.302775068882607;1.0445550701723987;0.7010064547316693;0.06537288980476162;1.718158449192021;2.9198635513655495;1.6395497960743348;ybbP;ABC-type transport system permease protein YbbP;COG3127;Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component;YbbP;HELO_RS14300;Q;ybbP; ABC-type transport system permease protein YbbP;;ybbP;ABC-type transport system permease protein YbbP;2.131572720800708;0.1890585620587517;0.4930506659554865;1.5726432701718487;-0.5589294506288591
HELO_3601;89.41785049594922;17.95510187742609;25.370528319903727;33.82169672921733;26.699454842837692;21.33232415350317;4.484014796008986;1.5592273939751358;3.245009394522298;5.516831967804874;3.131198283979106;2.1412583992503134;ybbA;ABC-type transport system ATP-binding protein YbbA;COG4181;Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component;YbbA;HELO_RS14305;Q;ybbA; ABC-type transport system ATP-binding protein YbbA;;ybbA;ABC-type transport system ATP-binding protein YbbA;2.2540214103277085;0.23979307305181052;0.31072418056485684;2.0174742187779167;-0.23654719154979187
HELO_3602;37.50199276617614;30.217167967099726;39.30344385734071;40.5453263137503;46.16137608441095;41.86424033242573;1.259906670814165;3.280992538208206;3.672838889898786;1.8954769355011356;5.611382124813337;2.590258886673112;tesA;esterase TesA;COG2755;Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK;TesA;HELO_RS14310;DI;tesA; esterase TesA;3.1.2.-,3.1.2.2,3.1.1.2,3.1.1.5;tesA;esterase TesA;0.30259345657148806;-0.08887145552206199;0.137831238928233;-0.15484145725686727;-0.4574349138283553
HELO_3603;85.29541077910623;49.43265305613827;79.51376288258422;87.06554822130438;78.53610606781204;82.02431683916713;3.2504403843121144;2.0728173006083535;3.839421642263371;2.4588574684371496;1.696610938620312;3.2732643568448734;HELO_3603;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS14315;GER;;tesA;;HELO_3603;DMT superfamily transport protein;0.7749257168123558;-0.04429853055509714;-0.06192401429873051;0.0557498917611996;-0.7191758250511562
HELO_3604;46.478884886936896;17.25615484222543;63.56384024818322;67.9753100791711;72.36974566696159;60.78598052651256;7.326644516552209;4.398308948565746;5.586697552696944;14.841839376565582;10.220100523794773;7.711110690637471;HELO_3604;thioredoxin domain protein;COG3526;Predicted selenoprotein, Rdx family;;HELO_RS14320;R;;;;HELO_3604;thioredoxin domain protein;1.378903118295172;0.0634468701845794;0.2479057618463445;-0.37999347076882994;-1.758896589064002
HELO_3605;60.442137959441936;8.940150174070482;15.32697444735294;14.36915104491221;19.075538174819695;16.002439162625564;7.826777690907623;2.2579041392604258;1.2310205930131133;0.8443832771322367;2.8296940723843034;3.75221573891267;HELO_3605;uncharacterized protein;;;;;;;;;HELO_3605;uncharacterized protein;2.6278888643386593;-0.058484259861598886;0.2396969336744661;1.8534866877691645;-0.7744021765694948
HELO_3606;403.0440835880034;336.63368576617194;556.8993879885662;406.72371222498776;503.7222691887377;596.1039674678852;16.743771080574223;18.30669195736205;42.89175934470593;29.24484328456859;60.585088991014395;42.29147770534306;HELO_3606;ABC-type transport system ATP-binding protein;COG0488;ATPase components of ABC transporters with duplicated ATPase domains;Uup;HELO_RS14330;R;;;;HELO_3606;ABC-type transport system ATP-binding protein;0.2590538589482563;-0.09797718599715566;-0.24249241260515397;-0.5634694466720518;-0.8225233056203081
HELO_3607;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;HELO_3607;ABC-type transport system ATP-binding protein;;;;;;;;;HELO_3607;ABC-type transport system ATP-binding protein;0.0;0.0;0.0;0.0;0.0
HELO_3608;127.4483493810378;77.17096026353862;94.91121751400073;99.54806162440038;98.50877215878025;104.19856986996292;3.945845981064741;2.6311677386856607;9.591859217079362;1.5372303717199705;6.016480251919037;1.2918236847127071;lpxP;lipid A biosynthesis lauroyltransferase;COG1560;Palmitoleoyl-ACP: Kdo2-lipid-IV acyltransferase (lipid A biosynthesis);LpxP;HELO_RS14340;I;lpxP; lipid A biosynthesis lauroyltransferase;2.3.1.241,2.3.1.-;lpxP;lipid A biosynthesis lauroyltransferase;0.7164836858081793;-0.13334362803988498;-0.08021947531551099;0.2880732591438102;-0.4284104266643691
HELO_3609;176.01359862741435;119.74707861342365;156.86112002995245;218.13715188573875;117.55488332289521;144.83410637690096;4.991237653725653;11.943605880842444;17.79359837222662;27.05844073486126;9.18740172629999;10.104780109176815;alr;alanine racemase;COG0787;Alanine racemase;Alr;HELO_RS14345;M;alr; alanine racemase;5.1.1.1;alr;alanine racemase;0.5518719114673045;0.11432772660105428;-0.2987730745150978;0.27953203226469014;-0.2723398792026144
HELO_3610;591.7000672491857;369.8525800098885;718.972358936357;1037.5069056903842;596.7104934198582;679.6850557902933;38.89901859143897;45.97710290611889;35.67385503061874;43.61765050566541;49.330387939251196;54.20035999162522;rpoS;RNA polymerase sigma factor RpoS;COG0568;DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32);RpoD;HELO_RS14350;K;rpoS; RNA polymerase sigma factor RpoS;;rpoS;RNA polymerase sigma factor RpoS;0.6764564153629156;0.08095408370247092;-0.18754056522359086;-0.19968521500121383;-0.8761416303641294
HELO_3611;719.7339389941221;367.88452045015856;733.989883103382;852.8847599296809;747.2836520781372;733.4331141303127;16.2313253647633;14.22742728047073;60.63763493332476;45.85311222897789;66.55001843650984;4.765540233259335;HELO_3611;peptidase M23 family protein;COG0739;Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain;NlpD;HELO_RS14355;M;;rpoS;;HELO_3611;peptidase M23 family protein;0.9662975324198282;0.0010932833858188218;0.02695414810409069;-0.027164325751739327;-0.9934618581715675
HELO_3612;174.82352636961696;74.23326328477478;97.28459606038302;101.790069160138;72.03388812191224;88.18653121862356;5.547750448379539;3.7940174337060966;5.452833299576475;3.2174119289115355;1.1714510086150427;5.919958199844218;HELO_3612;DUF368 family protein;COG2035;Uncharacterized membrane protein, DUF368 family;;HELO_RS14360;S;;;;HELO_3612;DUF368 family protein;1.2246855511535273;0.14013947018310002;-0.28825981581193627;0.9792303670614562;-0.24545518409207112
HELO_3613;162.02377128874014;132.7201627210664;72.75812046334067;85.32737477120702;72.52841281900577;70.69346119691835;2.9559633603674937;3.617330959966613;4.598738627670485;4.973990597236436;1.6031399435240674;1.316854751445195;pcm;protein-L-isoaspartate O-methyltransferase;COG2518;Protein-L-isoaspartate O-methyltransferase;Pcm;HELO_RS14365;O;pcm; protein-L-isoaspartate O-methyltransferase;2.1.1.77;pcm;protein-L-isoaspartate O-methyltransferase;0.2858653305213954;0.040960348943282376;0.03646029940524809;1.185168897154158;0.8993035666327627
HELO_3614;169.18881125028767;138.8884656168634;104.10006720136222;107.56887599889774;99.10519609462523;96.97467446146997;7.077954044897289;3.7554780614759595;6.949533269719546;8.10280138094672;3.7529520273688473;6.180859221988911;surE;5'-nucleotidase SurE;COG0496;Broad specificity polyphosphatase and 5'/3'-nucleotidase SurE;SurE;HELO_RS14370;L;surE; 5'-nucleotidase SurE;3.1.3.5;surE;5'-nucleotidase SurE;0.28285918158751144;0.1012828124312426;0.031036081807276794;0.7966554134816004;0.513796231894089
HELO_3615;214.41866988846365;171.75149987379248;177.43820709992636;203.07498347338523;175.3574277952149;176.14374954304776;1.7601759918992734;2.241378528250027;2.7073460172014006;8.988499560312464;5.89197004899528;4.401523870332774;truD;tRNA pseudouridine synthase TruD;COG0585;tRNA(Glu) U13 pseudouridine synthase TruD;TruD;HELO_RS14375;J;truD; tRNA pseudouridine synthase TruD;5.4.99.27;truD;tRNA pseudouridine synthase TruD;0.3184450541575581;0.01050399612697106;-0.006418221097214349;0.28222272933141834;-0.03622232482613974
HELO_3616;302.21982977492337;261.6505808884362;164.82856253341717;177.75979836256204;165.09912399761484;181.98687596630285;17.99878638149255;15.591300779255242;15.499458833102164;8.819508156635042;19.416859098479563;17.271681655437565;ispF;2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase;COG0245;2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase;IspF;HELO_RS14380;I;ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase;4.6.1.12;ispF;2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase;0.20721932981660274;-0.14204766047671225;-0.13969571585176777;0.7286239245976516;0.5214045947810488
HELO_3617;257.0765856691453;225.8685549223948;172.7150848290802;176.003593708351;159.58990514478737;172.44738472396557;11.421264509449948;10.660251256577538;6.0940112966416935;6.802230981993566;5.9887878679854065;12.56781874904434;ispD;2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;COG1211;2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;IspD;HELO_RS14385;I;ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;2.7.7.60;ispD;2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;0.18594259863677287;0.0022249507047202854;-0.11111688119586471;0.5733011694721615;0.3873585708353886
HELO_3618;141.18438411244452;141.61983429889804;141.80279698661957;133.57034189358288;106.50851786300193;137.22209726120823;18.570438735410903;31.715928045932632;12.14767610851894;23.052624001220327;14.52442933868597;23.411613081979123;ftsB;cell division protein FtsB;COG2919;Cell division protein FtsB;FtsB;HELO_RS14390;D;ftsB; cell division protein FtsB;;ftsB;cell division protein FtsB;-0.004411608209890616;0.04703596215258088;-0.3625373060553958;0.040774750095865286;0.0451863583057559
HELO_3619;44.170406360055786;21.07586957200137;31.253421992821814;70.73681005893889;38.29221159997714;31.183519380423775;1.6966312817351066;0.7637654801973414;1.8653639214248516;7.640439944503056;3.3985919963218345;0.8317098088577104;HELO_3619;PagP domain protein;;;;;;;;;HELO_3619;PagP domain protein;1.0329076255652057;0.003130135902273068;0.28792127512467314;0.4890557941071929;-0.5438518314580127
HELO_3620;14.145618339823434;4.800473988637225;8.511856804274158;11.078089743267732;8.166351456757953;7.529646395217928;0.940864971965723;0.07272934782756779;0.4001096710832952;1.1652118673368717;1.1695553457811065;0.925181441369058;HELO_3620;uncharacterized protein;;;;;;;;;HELO_3620;uncharacterized protein;1.3846577785437697;0.15724106181576714;0.10386166820827736;0.828342639690816;-0.5563151388529537
HELO_3621;15.944114995044325;11.609659271143387;11.330140001120483;11.898539542887399;8.008110186301794;11.73398503199202;0.2923406898560718;0.6947240359816316;0.5050753565481925;2.2991047245756167;1.169607212825651;3.207706710401134;HELO_3621;peptidase C39 family protein;COG3271;Predicted double-glycine leader peptidase, C39-like (CLD) domain;C39G;HELO_RS14405;U;;;;HELO_3621;peptidase C39 family protein;0.42625499289234803;-0.046494792792580064;-0.4993875939970396;0.41210031211320164;-0.014154680779146389
HELO_3622;10.800536988942293;7.894106735884567;14.560474118485311;15.942719333966323;18.8682291661895;15.985120590951121;0.42244016100524623;0.5447552854465296;0.2826210039027035;0.41089991019632477;3.0902377576963924;2.170139164428509;HELO_3622;uncharacterized protein;;;;;;;;;HELO_3622;uncharacterized protein;0.4079308882743309;-0.12638544203671298;0.226191831367486;-0.5254189495070962;-0.9333498377814271
HELO_3623;1.8905271272109134;0.853951290856668;1.4135410755944313;2.0458240289869187;1.8630725134339012;2.1910522455169534;0.4187452964229483;0.24451950242061415;0.13383190594814626;0.5469021742054192;0.24596828619207797;0.8107727612634691;HELO_3623;uncharacterized protein;;;;;;;;;HELO_3623;uncharacterized protein;0.6407292716027007;-0.4028808493987994;-0.1564680192044916;-0.142699617422968;-0.7834288890256687
HELO_3624;1.7979685368193319;0.6395872451421026;0.764760809229084;0.9830973024800668;0.587774638356466;0.6008618643742808;0.5249010741855215;0.30705896251060777;0.3845913915034225;0.1161898007573837;0.5107069552949933;0.2510450567656499;HELO_3624;uncharacterized protein;;;;;;;;;HELO_3624;uncharacterized protein;0.7710470675188943;0.14062383233097686;-0.01184266822472424;0.805530913932438;0.03448384641354374
HELO_3625;0.3283325866059044;0.15345117347074966;0.5689444055975154;0.3551590663245798;0.34811892759721347;0.22763536875145426;0.12920298097173225;0.0684303494297294;0.40285267362337557;0.3156513083760479;0.02043814549297572;0.10171500786608757;HELO_3625;uncharacterized protein;;;;;;;;;HELO_3625;uncharacterized protein;0.20365947762278874;0.35391211612612716;0.135065656756037;0.11373429624068876;-0.08992518138209998
HELO_3626;62.45830864504446;20.616132762528004;34.97976133311178;42.724157078030004;33.0394115005954;30.95548142308674;2.532976584503581;2.3032704285786973;5.4821080397266;8.796051064211074;3.137892200483226;2.0504999063243874;HELO_3626;response regulator/sigma-54-interact/HTH domain transcription regulator;COG2204;DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains;AtoC;HELO_RS14430;T;;;;HELO_3626;response regulator/sigma-54-interact/HTH domain transcription regulator;1.553700629016677;0.17112219433296172;0.09114267245773888;0.9897456472367177;-0.5639549817799594
HELO_3627;44.42127446393541;18.571528330282106;26.15966864349079;27.570379447994018;46.414429908462836;25.127238373189954;1.8622538802433977;0.9258928707092768;1.3676735340613155;1.7902032326365642;2.3325762496350584;1.7896652218964053;HELO_3627;DUF482 domain protein;COG3146;Predicted N-acyltransferase;;HELO_RS14435;R;;;;HELO_3627;DUF482 domain protein;1.2146117671688978;0.055911237275003245;0.8597715486168305;0.7978135457430273;-0.41679822142587053
HELO_3628;550.009332567132;625.0705563084475;1432.7787726167196;1066.1881500111733;116.67181022186433;1503.1645613847097;50.492011079459566;34.710022976601714;97.87082581827049;39.746964020159396;4.146676310541639;128.0326623530034;edd;phosphogluconate dehydratase;COG0129;Dihydroxyacid dehydratase/phosphogluconate dehydratase;IlvD;HELO_RS14440;GE;edd; phosphogluconate dehydratase;4.2.1.12;edd;phosphogluconate dehydratase;-0.1842484995548599;-0.06913997395586868;-3.676121761090754;-1.4488137526715086;-1.2645652531166487
HELO_3629;309.2473304970406;324.28465917110725;903.9133646806393;694.6242451044454;77.40009485670862;1014.8838025184068;29.291391977930118;41.37336884267105;63.012882874215165;44.64457273790318;8.365714545602982;90.18422788723706;glk;glucokinase;COG0837;Glucokinase;Glk;HELO_RS14445;G;glk; glucokinase;2.7.1.2;glk;glucokinase;-0.06828398785836676;-0.16688381307649003;-3.6957361850132937;-1.7112446931587133;-1.6429607053003465
HELO_3630;553.3674419786126;547.5431808298121;1234.8595082446718;976.0388714547693;247.22057597997582;1352.7635973228535;47.60588890233112;32.13276835789012;80.35132816825829;15.728385111678081;6.279732694675294;97.16535963552154;HELO_3630;epimerase domain protein;COG0676;D-hexose-6-phosphate mutarotase;YeaD;HELO_RS14455;G;;glk;5.1.3.15;HELO_3630;epimerase domain protein;0.015237337662165729;-0.13146108059361694;-2.44728121225965;-1.288061392924618;-1.3032987305867838
HELO_3631;527.3457330890524;493.23294081977747;1211.9798502655874;916.6842194439968;185.61730400581746;1339.0212759578476;30.693049109781814;20.63661467501786;97.74921033294939;27.779969088640783;13.892630892809148;120.25118123393577;HELO_3631;probable fructokinase;COG0524;Sugar or nucleoside kinase, ribokinase family;RbsK;HELO_RS14460;G;;;2.7.1.4;HELO_3631;probable fructokinase;0.09629112350180691;-0.14370032205918193;-2.844101236252472;-1.3427017083305515;-1.4389928318323584
HELO_3632;8.818887864838702;21.50907056377804;13.31662418059544;16.13175468820534;9.840034410858037;15.648907701055059;1.0974067490158477;2.2981520638389084;1.9242961008538753;2.2028168181703927;2.3772205242358475;1.0036522939924122;HELO_3632;MatC domain protein;COG0471;Di- and tricarboxylate antiporter;CitT;HELO_RS14465;G;;;;HELO_3632;MatC domain protein;-1.1968749545670216;-0.21773617898832676;-0.6190581918658471;-0.7617959960651564;0.4350789585018653
HELO_3633;2.2257062577569426;8.197306076483683;6.986377223902529;7.775459391863421;1.7447965001983743;6.497178826300098;0.11868589970182729;1.1407725806635554;0.3503794380959576;0.7396691546864491;0.7270162075254512;1.3713135178336928;HELO_3633;amidohydrolase domain protein;COG3618;Predicted metal-dependent hydrolase, TIM-barrel fold;;HELO_RS14470;R;;;;HELO_3633;amidohydrolase domain protein;-1.511596284111483;0.09119340259056896;-1.4496486229338785;-1.2167327459628676;0.2948635381486153
HELO_3634;55.489204165091216;41.967332515683275;51.38411028830449;57.978915188572785;71.75306015078563;51.00246090664506;4.158260625057107;0.5228184382654357;4.090026723574001;3.8414409373782408;3.7491779242897447;4.132071573153842;HELO_3634;HutC family transcription regulator;COG2188;DNA-binding transcriptional regulator, GntR family;MngR;HELO_RS14475;K;;;;HELO_3634;HutC family transcription regulator;0.3947349607899211;0.010549366979581976;0.4844280348000449;0.11939527838025654;-0.27533968240966455
HELO_3635;1461.734822494244;1957.2175361157417;1814.9344410770227;1654.573431523413;96.62219430058703;1956.6701035418155;115.43984902734523;72.210599937456;114.93897420199315;188.32825127366658;3.580419276851738;81.38363170483404;eda;2-keto-3-deoxy-phosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase;COG0800;2-keto-3-deoxy-6-phosphogluconate aldolase;Eda;HELO_RS14480;G;eda; 2-keto-3-deoxy-phosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase;4.1.2.14,4.1.3.42;eda;2-keto-3-deoxy-phosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase;-0.4208727924994822;-0.10842555055739034;-4.325784679438758;-0.42046942123991293;0.0004033712595692407
HELO_3636;1632.9848360154247;1529.5975890976194;1841.1116515077044;1496.0405956951547;103.25209785650719;1836.5405560404488;118.61143618060225;51.156397827884966;64.39906912572425;42.45896854240956;5.5518543057162395;107.04021042761411;pgl;6-phosphogluconolactonase;COG0363;6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase;NagB;HELO_RS14485;G;pgl; 6-phosphogluconolactonase;3.1.1.31;pgl;6-phosphogluconolactonase;0.094299562469077;0.003584414929685309;-4.139627771463687;-0.16938149697231886;-0.26368105944139586
HELO_3637;803.6866701174207;755.212442075544;1327.7731145590003;1120.2543881792865;93.44465632578179;1402.2322546421722;8.067638789372825;19.431184667287017;103.11638373925734;73.25412935648654;8.932060873290492;97.33069213102037;zwf;glucose-6-phosphate 1-dehydrogenase (NAD(P));COG0364;Glucose-6-phosphate 1-dehydrogenase;Zwf;HELO_RS14490;G;zwf; glucose-6-phosphate 1-dehydrogenase (NAD(P));1.1.1.49,1.1.1.363;zwf;glucose-6-phosphate 1-dehydrogenase (NAD(P));0.08963554780737759;-0.07865902675587932;-3.893140833478226;-0.802254775692596;-0.8918903234999735
HELO_3638;339.6014464122848;223.32700814854044;362.8605202927495;314.5715798915799;159.68405363224187;382.5607519273653;14.207310596330343;5.37357611046754;9.29267486024826;8.335433841005107;7.487487693324949;14.93776940799602;hexR;RpiR family transcription regulator HexR;COG1737;DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains;RpiR;HELO_RS14495;K;hexR; RpiR family transcription regulator HexR;;hexR;RpiR family transcription regulator HexR;0.6024812355686553;-0.07606957939024461;-1.2552283409934875;-0.17137054167748111;-0.7738517772461364
HELO_3639;391.0024845759361;203.75923752194277;382.5894470265045;225.80545677875173;330.50310573963753;414.77306361664813;20.185547329358798;8.417451701649915;15.797091668194158;11.87016906666407;16.93121935411144;29.217533114295453;HELO_3639;ABC-type transport system periplasmic substrate-binding protein;COG3221;ABC-type phosphate/phosphonate transport system, periplasmic component;PhnD;HELO_RS14500;P;;hexR;;HELO_3639;ABC-type transport system periplasmic substrate-binding protein;0.9369342592317844;-0.11623326365001496;-0.32677390788301786;-0.08493349599556588;-1.0218677552273503
HELO_3640;269.90628366533696;150.9789287599244;173.3217522978138;104.40943602886425;155.20816238762953;182.9117561069414;6.405734723107292;1.1910218853227321;4.927377342737469;3.0186004018040555;9.48845903037898;14.347850986426074;HELO_3640;ABC-type transport system ATP-binding protein;COG3638;ABC-type phosphate/phosphonate transport system, ATPase component;PhnC;HELO_RS14505;P;;;7.3.2.2;HELO_3640;ABC-type transport system ATP-binding protein;0.8339225432815027;-0.07726109969304318;-0.23554386244550418;0.5587801537762962;-0.27514238950520653
HELO_3641;83.38874917309641;53.56992336578772;58.57377037499004;45.572240599845024;59.25472018802129;61.621020854760665;2.673382660981056;4.644943588393707;0.9974396716979551;3.1427701072378045;2.2355524677971736;1.6372635261958903;HELO_3641;ABC-type transport system permease protein;COG3639;ABC-type phosphate/phosphonate transport system, permease component;PhnE;HELO_RS14510;P;;;;HELO_3641;ABC-type transport system permease protein;0.6289446519268465;-0.07196975868631394;-0.05557276513501552;0.43040364197673675;-0.1985410099501097
HELO_3642;323.4555813420454;259.728806068938;361.37720182238263;435.6960572104992;271.63455580371004;337.49406205985736;2.1089302488666033;24.969375109443178;40.60261238296816;32.12468627573863;10.512537279824944;24.028085064282926;HELO_3642;RutC family protein;COG0251;Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family;RidA;HELO_RS14515;V;;;;HELO_3642;RutC family protein;0.31547099894887154;0.09836166826568338;-0.3121620939212413;-0.06110954220770459;-0.37658054115657613
HELO_3643;33.85177298064049;27.94787901835835;57.18847917253617;82.17593998438245;66.36915427648758;48.44283020908119;9.830515434415931;2.350945470049747;11.545101976579742;16.312060539246136;5.513039572047892;7.4674868329319;HELO_3643;uncharacterized protein;;;;;;;;;HELO_3643;uncharacterized protein;0.26777440350521875;0.23497221154163572;0.4463268600319372;-0.5045292776369568;-0.7723036811421755
HELO_3644;131.00787405379546;94.494033586788;139.58521046947797;123.03946324850574;133.155211563049;148.00182191664717;4.748891224392706;3.5869350927847736;12.343399055658445;9.222628182046169;7.589396532625311;3.6843500689650956;HELO_3644;UspA domain protein;COG0589;Nucleotide-binding universal stress protein,  UspA family;UspA;HELO_RS14520;T;;;;HELO_3644;UspA domain protein;0.4671414842434958;-0.08388514009885384;-0.1514268708750297;-0.1747059847685195;-0.6418474690120153
HELO_3645;25.602158959181;58.32600451290727;29.815992820102753;29.195263351056976;23.75984145660151;31.18224383817332;0.6593550523386074;1.8620889468723631;1.3522271657049743;2.521111947012095;2.3178475976324115;1.711813496900134;ybaR;SulP family transport protein (probable substrate sulfate);COG0659;Sulfate permease or related transporter, MFS superfamily;SUL1;HELO_RS14525;P;ybaR; SulP family transport protein (probable substrate sulfate);;ybaR;SulP family transport protein (probable substrate sulfate);-1.1571212877595256;-0.06258564623983354;-0.378262841748648;-0.2747215826961602;0.8823997050633654
HELO_3646;9.101264581252444;5.030400644111021;7.387235543729563;10.065569855589288;8.652493804169445;6.149414651056269;0.6442950516704526;0.8566760122166698;0.552816877260725;1.315381405246325;0.9087878540083912;0.08964684280436476;HELO_3646;stomatin family protein;COG0330;Regulator of protease activity HflC, stomatin/prohibitin superfamily;HflC;HELO_RS14530;O;;ybaR;;HELO_3646;stomatin family protein;0.7442101565155026;0.2303702447343725;0.43307659515453434;0.49863888276293933;-0.24557127375256327
HELO_3647;15.667133724908274;7.977478596295366;7.407092898404977;10.38112020618865;15.09829363064909;7.042377735541289;1.4273039635459592;0.8491221746604523;0.2541377366670672;0.2896456975683115;0.6092224111243753;1.0019222526126685;HELO_3647;PH1510-type membrane-bound protease;COG1030;Membrane-bound serine protease NfeD, ClpP class;NfeD;HELO_RS14535;O;;;;HELO_3647;PH1510-type membrane-bound protease;0.8926238095588599;0.06398491653882932;1.0012137716820857;1.051312019408147;0.158688209849287
HELO_3648;17.09430472103982;17.590468990598932;14.51160618830829;17.322677672800726;30.834468475577594;16.12526251695706;0.7047281173832075;1.7614076467704793;2.060481532520741;0.6155492503010872;3.775059912884261;2.7174161560728494;HELO_3648;LsrG family protein;COG1359;Quinol monooxygenase YgiN;YgiN;HELO_RS14540;C;;;5.3.1.32;HELO_3648;LsrG family protein;-0.03902749347425516;-0.1427780220373256;0.8944635728193928;0.07940956916011999;0.11843706263437515
HELO_3649;16.407930005067286;16.579952446205976;14.724676296584265;15.631417893962052;52.163015487076656;14.115690827729045;0.605684477862482;2.3959734482734993;2.1716450711397406;1.6696654814638285;2.974160387064899;1.0238418930972475;HELO_3649;glyoxalase domain protein;COG2514;Catechol-2,3-dioxygenase;CatE;HELO_RS14545;Q;;;;HELO_3649;glyoxalase domain protein;-0.014186507163780782;0.056983403011511946;1.8143760232751278;0.20369774531456564;0.21788425247834642
HELO_3650;18.485344756141984;15.298387267451837;36.622580927927594;34.97484181330479;35.81702067459461;35.670018365709005;1.7082962302000972;0.17944574077926473;4.890048763775522;4.810317291758518;6.065478099089573;3.0518688223442445;ynjB;probable ABC-type transport system periplasmic substrate-binding protein YnjB;COG4134;ABC-type uncharacterized transport system YnjBCD, periplasmic component;YnjB;HELO_RS14550;R;ynjB; probable ABC-type transport system periplasmic substrate-binding protein YnjB;;ynjB;probable ABC-type transport system periplasmic substrate-binding protein YnjB;0.2576602412660751;0.03699783325448447;0.005771896314781699;-0.9122115311255348;-1.1698717723916099
HELO_3651;16.797450735069457;9.58095936921901;15.10558074821428;14.724419743030024;16.818203035756266;17.308604133650288;0.5606152349944101;0.6475310673697898;2.230677707392613;1.483793582302794;1.2727684490269509;2.1894845998540577;ynjC;ABC-type transport system permease protein YnjC;COG4135;ABC-type uncharacterized transport system YnjBCD, permease component;YnjC;HELO_RS14555;R;ynjC; ABC-type transport system permease protein YnjC;;ynjC;ABC-type transport system permease protein YnjC;0.7502001660763535;-0.18496111927309666;-0.03916995428535497;-0.04085119506047885;-0.7910513611368324
HELO_3652;16.726338614869032;11.12112373069759;14.721825419485802;14.842994430425188;17.33274732261547;16.96974729641575;0.5238853774684675;0.8141120302666013;0.8997315651202398;0.6846069487560136;1.0829018477680212;1.2467912726568673;ynjD;ABC-type transport system ATP-binding protein YnjD;COG4136;ABC-type uncharacterized transport system YnjBCD, ATPase component;YnjD;HELO_RS14560;R;ynjD; ABC-type transport system ATP-binding protein YnjD;;ynjD;ABC-type transport system ATP-binding protein YnjD;0.5483711224970906;-0.1928013859496427;0.028852881786709084;-0.01967554322763121;-0.5680466657247218
HELO_3653;8.51463657104967;7.220201168693719;14.59002551658734;12.926808694000108;19.978193364887694;13.221037994119882;1.2326959762410117;0.7784883046537632;1.7811066254568297;1.787666026582239;1.2225156634912488;0.17274837711047644;HELO_3653;DUF2282 domain protein;COG5572;Uncharacterized membrane protein;;HELO_RS14565;S;;ynjD;;HELO_3653;DUF2282 domain protein;0.21097485051341014;0.13259651816489537;0.5608636676744001;-0.5798063148801016;-0.7907811653935117
HELO_3654;5.29668295552597;3.7817388136835413;5.961812948934693;5.9869889702180075;6.417953682457516;5.750372443069371;0.4360268208713942;1.1090432420478804;0.6861773134323147;0.17483581231418444;0.6848886174534826;0.7924244072495643;HELO_3654;UPF0276 family protein;COG3220;Uncharacterized conserved protein, UPF0276 family;;HELO_RS14570;S;;;;HELO_3654;UPF0276 family protein;0.39705669813576794;0.044495948836703825;0.13605415651989716;-0.10037507519420963;-0.49743177332997757
HELO_3655;3.6641873926945885;1.9506999963127225;4.162314890660249;3.1312290812628945;4.05193789653194;3.615489476729037;0.6346078487997404;0.26638877270334993;1.1949045172246047;1.1977559393826824;0.7044927481413871;0.1334474714067288;HELO_3655;DUF2063 domain protein;COG3219;Uncharacterized conserved protein, DUF2063 family;;HELO_RS14575;S;;;;HELO_3655;DUF2063 domain protein;0.6605685062708213;0.16153449049985324;0.1303532491198709;0.015142097683676248;-0.6454264085871451
HELO_3656;2.9477917806613516;1.3314608045495728;1.8059068688147721;2.6159983709232772;2.075525611393243;1.6598883173496735;0.5105338783613296;0.4829905811577385;1.1327736479262396;0.5938322111174313;0.2810366369209815;0.10160316509049407;HELO_3656;DoxX domain protein;COG2259;Uncharacterized membrane protein YphA, DoxX/SURF4 family;DoxX;HELO_RS14580;S;;;;HELO_3656;DoxX domain protein;0.7598117234328305;0.07710145357119447;0.20946731849246847;0.5696802278664173;-0.1901314955664133
HELO_3657;28.54259580349215;19.206709538472897;38.08121135712141;47.59673720402654;43.92052156940494;31.696036545449193;1.2817690009706366;1.2121164791176453;0.9911790425202789;4.719891594352183;6.1568532424338835;2.1049125475712054;HELO_3657;RNA polymerase sigma-70 factor domain protein;COG1595;DNA-directed RNA polymerase specialized sigma subunit, sigma24 family;RpoE;HELO_RS14585;K;;;;HELO_3657;RNA polymerase sigma-70 factor domain protein;0.5479621838716122;0.2573594246028481;0.4582589178584717;-0.14631916483333463;-0.6942813487049468
HELO_3658;69.74931657926079;22.58987936629461;42.19711669531367;47.2601592747338;47.492150684331115;42.72463827988748;3.40748127371202;0.9605938013988604;5.1380461778466255;1.1005670161572396;2.1552673829433204;2.6328415807821335;HELO_3658;HAD superfamily hydrolase;COG1011;FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis);YigB;HELO_RS14595;H;;;3.8.1.2;HELO_3658;HAD superfamily hydrolase;1.5845481709820524;-0.017511430092728375;0.14930479115119688;0.6942697627016177;-0.8902784082804347
HELO_3659;27.09871099324268;13.496031930360322;15.173997257347702;19.004364953790667;17.031552010467625;15.726340509083556;2.674026905300088;0.8440656206150267;0.4102982206483136;1.515105284187733;2.589779115510805;0.7759442637488388;eutC;OCD family protein EutC;COG2423;Ornithine cyclodeaminase/archaeal alanine dehydrogenase, mu-crystallin family;OCDMu;HELO_RS14600;E;eutC; OCD family protein EutC;;eutC;OCD family protein EutC;0.9548459111189498;-0.048445566341809965;0.10840173939063202;0.7483821111693754;-0.20646379994957442
HELO_3660;29.147349875685276;19.960122065022777;21.367266687126374;25.57897024218987;21.963164221952827;21.334523488238244;0.16116473465800432;1.7461773562329768;1.9169609438469837;0.7288658516979708;1.340539068033617;1.031517289111173;eutB;L-threonine dehydratase family protein EutB;COG1171;Threonine deaminase;IlvA;HELO_RS14605;E;eutB; L-threonine dehydratase family protein EutB;4.3.1.19;eutB;L-threonine dehydratase family protein EutB;0.5243840678689473;0.0021134929461075203;0.04004597790800535;0.4327557117945737;-0.09162835607437358
HELO_3661;76.31477066395297;33.164090104183884;39.37714287182535;44.08617372907778;74.28541939399189;77.1910267053073;4.676469684765993;1.319877430143683;1.9045417923090524;4.3119961611547835;10.139875931661491;9.971467289128775;doeD;diaminobutyrate--2-oxoglutarate aminotransferase;COG0161;Adenosylmethionine-8-amino-7-oxononanoate aminotransferase;BioA;HELO_RS14610;H;doeD; diaminobutyrate--2-oxoglutarate aminotransferase;2.6.1.76;doeD;diaminobutyrate--2-oxoglutarate aminotransferase;1.1782633574673094;-0.9534642239475559;-0.05463256795204163;-0.01625899030084188;-1.1945223477681512
HELO_3662;51.10325364333958;22.199465564136215;22.211533492551883;28.04102857238827;44.49078480448049;66.04083106404745;2.992218051378944;1.785560112103699;2.3737918702666465;1.0533554935080254;5.880542389027499;3.6312231230734855;doeC;aspartate-semialdehyde dehydrogenase (NAD(P)) (non-phosphorylating);COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS14615;I;doeC; aspartate-semialdehyde dehydrogenase (NAD(P)) (non-phosphorylating);1.2.1.-;doeC;aspartate-semialdehyde dehydrogenase (NAD(P)) (non-phosphorylating);1.1672818949441588;-1.530198194470266;-0.5594657092147317;-0.36366656740334946;-1.5309484623475083
HELO_3663;146.51797577799348;48.261183789862294;25.20787272996529;21.38069114744745;67.24785110294863;64.74755720185881;6.420547581874698;3.4526344040815906;3.780784281304474;1.2079953812725028;1.4149027568646741;8.804611854254528;doeX;Lrp/AsnC family transcription regulator DoeX;COG1522;DNA-binding transcriptional regulator, Lrp family;Lrp;HELO_RS14620;K;doeX; Lrp/AsnC family transcription regulator DoeX;;doeX;Lrp/AsnC family transcription regulator DoeX;1.5823675619413233;-1.3269370370871147;0.053846327880755496;1.1658815662188795;-0.4164859957224438
HELO_3664;231.43736853014045;56.13717495634444;16.00542619759792;18.201973267982662;82.52964570583453;79.35879507547212;3.5674302138007605;3.344280897766301;1.0237016244189026;2.2351558988699787;7.2413895992019155;6.9374062605111915;doeB;N-alpha-acetyl-L-2%2C4-diaminobutyric acid deacetylase;COG3608;Predicted deacylase;;HELO_RS14625;R;doeB; N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase;3.5.1.125;doeB;N-alpha-acetyl-L-2%2C4-diaminobutyric acid deacetylase;2.024340415109841;-2.2404607680522233;0.05583238679043756;1.5323141896966401;-0.49202622541320107
HELO_3665;200.19442388357288;37.8094686319734;0.06335118526551296;0.07408332979737647;62.899872555478964;88.78952924918097;9.872971952454241;2.9437506499463177;0.06567255149229949;0.031695058788830166;6.422095616180981;11.276171268034624;doeA;ectoine hydrolase;COG0006;Xaa-Pro aminopeptidase;PepP;HELO_RS14630;E;doeA; ectoine hydrolase;3.5.4.44;doeA;ectoine hydrolase;2.3741097359037227;-6.3998571666971;-0.49073416197377817;1.1639712004199385;-1.2101385354837841
HELO_3666;120.01164111269338;48.32240453814698;54.91709987785498;41.00066646830606;41.55017396219526;51.19426305333252;7.09232040033519;1.1296461895487706;1.157379841526672;3.3819374840089473;2.8110139271152;2.3268093247508896;HELO_3666;YjiR family protein;COG1167;DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain;ARO8;HELO_RS14635;KE;;doeA;;HELO_3666;YjiR family protein;1.294830798942935;0.0993982964557274;-0.2947262110503788;1.2131826925657636;-0.08164810637717146
HELO_3667;118.12885897499051;42.41405399096502;82.58162756717581;83.49361929181407;101.24468540317521;89.43041596507253;5.133109386551571;3.2570257548559094;3.0836102680949073;6.021941934439967;3.7893137039224176;4.978382813736764;ghrA;glyoxylate/hydroxypyruvate reductase;COG0111;Phosphoglycerate dehydrogenase or related dehydrogenase;SerA;HELO_RS14640;H;ghrA; glyoxylate/hydroxypyruvate reductase;1.1.1.79,1.1.1.81;ghrA;glyoxylate/hydroxypyruvate reductase;1.456288896111161;-0.11362224764374318;0.17714585000111605;0.39764294354017604;-1.058645952570985
HELO_3668;55.96910699194428;28.560299515973977;31.36909265414368;38.2946379084733;40.157563473428546;34.83662865966707;2.507926859787975;0.5691192916456752;0.9555226339618724;2.235511257031239;5.891070259265032;4.448467437905732;pncA;nicotinamidase;COG1335;Nicotinamidase-related amidase;PncA;HELO_RS14645;HR;pncA; nicotinamidase;3.5.1.19,3.5.1.-;pncA;nicotinamidase;0.9465189042207713;-0.14681799628042835;0.1997226553939333;0.6687448698417775;-0.27777403437899384
HELO_3669;36.756216951653016;15.105416750516378;16.979837654488634;20.684713878298965;24.43213060833338;16.985015372831885;1.0688833834526636;1.218255723462837;1.3851369323580727;1.4213848642131877;2.647234720529562;1.408342931977846;pncB;nicotinate phosphoribosyltransferase;COG1488;Nicotinic acid phosphoribosyltransferase;PncB;HELO_RS14650;H;pncB; nicotinate phosphoribosyltransferase;6.3.4.21;pncB;nicotinate phosphoribosyltransferase;1.2291682256732956;-0.00041539825689618226;0.4998569380315727;1.069918826030161;-0.15924939964313456
HELO_3670;132.5519135996891;37.17107606288431;109.900284502421;119.0080343774406;169.63452902519788;117.65159001325439;6.690911431094001;4.585173866821718;0.9821140357397211;10.88361209577157;16.97972442469086;4.509015332149719;HELO_3670;glyoxalase;COG0693;Protein/nucleotide deglycase, PfpI/YajL/DJ-1 family (repair of methylglyoxal-glycated proteins and nucleic acids);YajL;HELO_RS14655;V;;pncB;3.5.1.124;HELO_3670;glyoxalase;1.8068488852109006;-0.09746836719234153;0.5241781813074491;0.17066921401748036;-1.6361796711934202
HELO_3671;154.70302706613518;33.07119809997565;67.98657209798769;72.67435130683515;68.1647295810236;70.48043388334035;10.835672705586271;2.725261639879629;5.078244270657882;7.528275196794922;5.365579705278844;3.4452124137078544;HELO_3671;DUF3108 family protein;;;;;;;;;HELO_3671;DUF3108 family protein;2.1921724072980693;-0.05123281588943218;-0.04751186564676235;1.1231766959086196;-1.0689957113894497
HELO_3672;144.59698619189015;35.258698859488675;88.70937083562056;93.18554304328211;74.3671087542982;85.04446587730739;10.824269419428632;3.237421807943856;2.150323828972239;5.220363820563875;6.630105645098208;14.437872548763437;lysO;LysO family transport protein (probable substrate lysine);COG2431;Lysine export protein LysO/YbjE, DUF340 family;LysO;HELO_RS14665;E;lysO; LysO family transport protein (probable substrate lysine);;lysO;LysO family transport protein (probable substrate lysine);2.005581432421547;0.06017628821976384;-0.19114735659271087;0.758826182016934;-1.2467552504046129
HELO_3673;15.38269665203388;42.52173020850037;343.2542782895113;577.065216491489;10.365894644255468;302.44328750179824;1.279657475002862;3.7419743470075595;18.7207980068568;42.8715364154935;0.46591269983835953;39.77820634166682;scrY;sucrose porin;COG4580;Maltoporin (phage lambda and maltose receptor);LamB;HELO_RS14670;G;scrY; sucrose porin;;scrY;sucrose porin;-1.4095630627123317;0.18204767688107637;-4.738643754306716;-4.211182152434176;-2.8016190897218447
HELO_3674;27.201818744545914;26.923782456425247;697.7347293621857;1605.052102029984;15.705832245656609;688.5927217904588;0.8985431123486395;1.2176997317645732;91.60072224209434;137.01136213150133;0.5619172685291962;129.40680390081855;thuE;ABC-type transport system periplasmic substrate-binding protein (probable substrate trehalose);COG1653;ABC-type glycerol-3-phosphate transport system, periplasmic component;UgpB;HELO_RS14675;G;thuE; ABC-type transport system periplasmic substrate-binding protein (probable substrate trehalose);;thuE;ABC-type transport system periplasmic substrate-binding protein (probable substrate trehalose);0.014293828368755257;0.019000300848048823;-5.367320786502261;-4.611884437171594;-4.626178265540349
HELO_3675;12.706829965679175;11.344300678774461;176.02549003327672;346.7861811472381;4.634729662874918;187.07448616851275;0.29275178245302447;0.5147140524509486;30.11345892545799;64.00094209083389;0.5173880019388917;7.903672224542365;thuF;ABC-type transport system permease protein (probable substrate trehalose);COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS14680;G;thuF; ABC-type transport system permease protein (probable substrate trehalose);;thuF;ABC-type transport system permease protein (probable substrate trehalose);0.15104984356143802;-0.08734703882765782;-5.0608139426559475;-3.778337291979325;-3.9293871355407632
HELO_3676;11.004642689228568;9.795490351311738;180.85166378010413;324.8956463927971;5.0942735609602545;178.79367215848583;1.175819276636855;1.1468415579550053;31.31256551469238;63.601474476112344;0.9277458127945616;11.354820229357658;thuG;ABC-type transport system permease protein (probable substrate trehalose);COG0395;ABC-type glycerol-3-phosphate transport system, permease component;UgpE;HELO_RS14685;G;thuG; ABC-type transport system permease protein (probable substrate trehalose);;thuG;ABC-type transport system permease protein (probable substrate trehalose);0.15316368853204043;0.01641987915537424;-4.882744174383726;-3.904677877674418;-4.057841566206458
HELO_3677;22.897251469153456;28.74863563078901;400.21478547420475;732.8208155485178;13.134834459850888;391.663056680631;1.661357975213125;0.5636119857113485;52.48680784496644;106.25538915053063;0.9501446697129042;41.76261332534451;aglA;alpha-glucosidase;COG0366;Glycosidase/amylase (phosphorylase);AmyA;HELO_RS14690;G;aglA; alpha-glucosidase;3.2.1.20;aglA;alpha-glucosidase;-0.3159788063762221;0.031082902954480573;-4.795964977584164;-4.038375267852073;-3.722396461475851
HELO_3678;19.31488595031831;30.244635678346242;408.0326865630639;849.5419618558866;15.098080641939612;412.11137775979;1.1483354231207787;1.0348636671522522;50.160460584675874;144.28117645711853;1.0616964744154958;50.284133674176154;thuK1;ABC-type transport system ATP-binding protein (probable substrate trehalose);COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS14695;G;thuK1; ABC-type transport system ATP-binding protein (probable substrate trehalose);;thuK1;ABC-type transport system ATP-binding protein (probable substrate trehalose);-0.6210712527827367;-0.014314658692159199;-4.6815702022922805;-4.345921624632371;-3.7248503718496346
HELO_3679;28.712136807497075;38.81989178034426;628.7653577147511;1054.5130976272628;23.99631328644742;637.8447800386649;1.5563614957720533;1.0770683131150178;62.39873183524395;149.49061824518503;1.6118429248445696;73.53216331770786;thuK2;ABC-type transport system ATP-binding protein (probable substrate trehalose);COG3839;ABC-type sugar transport system, ATPase component MalK;MalK;HELO_RS14700;G;thuK2; ABC-type transport system ATP-binding protein (probable substrate trehalose);7.5.2.-;thuK2;ABC-type transport system ATP-binding protein (probable substrate trehalose);-0.42243693701859897;-0.02065104294736031;-4.675678210308325;-4.426341174180963;-4.003904237162364
HELO_3680;7.916045429251576;6.047041324223003;78.98100473958806;151.37417717467122;9.578448084764565;82.35078012931193;2.237208205341577;0.8036656217984446;8.809897219574468;21.181413522795637;0.16073300461301412;11.634546034900957;HELO_3680;DUF1993 family protein;COG3812;Uncharacterized conserved protein, DUF1993 domain;;HELO_RS14705;S;;thuK2;;HELO_3680;DUF1993 family protein;0.339386293335175;-0.059538297586750666;-2.9780677104592876;-3.2247198297282424;-3.5641061230634175
HELO_3681;6.933734529398671;6.134420250629685;158.3397269854735;320.010390038329;9.801344998229638;162.52485880192557;0.4808171806415409;1.2409332050787543;16.579181607947337;44.480207840713156;0.7923682373001105;32.14181200892087;HELO_3681;MalM family protein;;;;;;;;;HELO_3681;MalM family protein;0.15320392451361675;-0.037403960612017784;-3.9202270936712424;-4.365366034201454;-4.518569958715071
HELO_3682;7.6397091449495065;4.352809531055785;408.62936404049975;1012.4271135012073;5.494632799830645;411.22018294543744;0.47683529778321415;0.34818636270440667;31.378543994832047;165.29308025796252;0.5331221177059856;100.15919149477405;lamB1;maltoporin;COG4580;Maltoporin (phage lambda and maltose receptor);LamB;HELO_RS14715;G;lamB1; maltoporin;;lamB1;maltoporin;0.6906864268348283;-0.009096005422073006;-5.988023373572575;-5.576288587984507;-6.2669750148193355
HELO_3683;1.8175336307709706;0.8498521131857523;18.157516262335935;32.23214309200884;1.000395851671554;18.09623343882414;0.16020397081483298;0.19925639548970248;1.8452039783254006;4.916073313669477;0.3846082390410046;1.8977731596232756;malG;ABC-type transport system permease protein (probable substrate maltose);COG3833;ABC-type maltose transport system, permease component MalG;MalG;HELO_RS14720;G;malG; ABC-type transport system permease protein (probable substrate maltose);;malG;ABC-type transport system permease protein (probable substrate maltose);0.6070228920666249;0.004622422737521781;-3.2549306841532655;-2.760783371658847;-3.367806263725472
HELO_3684;3.508183711622942;1.827780570890124;36.92170968341211;72.3818554377621;1.9005927975647807;36.32647560081279;0.34890007394217126;0.19669504403166613;1.7013345487811211;14.772084043590576;0.27543588434955346;6.964455688165036;malF;ABC-type transport system permease protein (probable substrate maltose);COG1175;ABC-type sugar transport system, permease component;UgpA;HELO_RS14725;G;malF; ABC-type transport system permease protein (probable substrate maltose);;malF;ABC-type transport system permease protein (probable substrate maltose);0.6728761327802508;0.02282471445017009;-3.685779613746604;-3.0495810818690257;-3.7224572146492765
HELO_3685;7.619098886156849;2.5136821681045265;148.1843481307486;270.3860941756504;3.0495551821080547;138.47182456494988;0.5730086114784638;0.2643657585389767;8.992584194789314;61.02847538292517;0.6215312632583134;34.83626914099409;malE;ABC-type transport system periplasmic substrate-binding protein (probable substrate maltose);COG2182;Maltose-binding periplasmic protein MalE;MalE;HELO_RS14730;G;malE; ABC-type transport system periplasmic substrate-binding protein (probable substrate maltose);;malE;ABC-type transport system periplasmic substrate-binding protein (probable substrate maltose);1.2945533480593214;0.09712247621841552;-5.1060664490471614;-4.016292849270149;-5.310846197329472
HELO_3686;24.40196948839524;16.75207185711039;145.2896993039176;318.40869057646023;11.133988007118903;132.97116264607305;1.8562453543789825;1.4689809245176269;11.277976617153776;12.26831369805161;1.2893542639263968;8.911663493767692;malT;MalT family transcription regulator MalT;COG2909;ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT;MalT;HELO_RS14735;K;malT; MalT family transcription regulator MalT;;malT;MalT family transcription regulator MalT;0.516952945243637;0.1269056952377987;-3.464796797655069;-2.398910230555124;-2.915863175798761
HELO_3687;6.528733086896048;2.960314726058011;109.1392989127611;186.72355800087658;1.945810672648595;99.93020732832535;0.7429254030136097;0.23170471723106434;14.715065642726058;29.096216102738932;0.3340142362983056;10.047362115058384;HELO_3687;probable glycoside hydrolase (homolog to alpha-glucosidase);COG0366;Glycosidase/amylase (phosphorylase);AmyA;HELO_RS14740;G;;malT;3.2.1.20;HELO_3687;probable glycoside hydrolase (homolog to alpha-glucosidase);0.9267920270550083;0.1259713079934679;-5.098549500700896;-3.7448070991603086;-4.671599126215317
HELO_3688;42.13889518808142;32.88826585274734;78.82858783123885;94.50371379850715;54.00145898705221;75.79881596091764;3.6123593099295483;1.2845143918517763;3.9685447411578436;9.461901903563543;3.3125500521775058;8.155611391570389;HELO_3688;LacI family transcription regulator;COG1609;DNA-binding transcriptional regulator, LacI/PurR family;PurR;HELO_RS14745;K;;;;HELO_3688;LacI family transcription regulator;0.34820341632152907;0.05582142152065028;-0.4816141799373739;-0.8320948397705807;-1.1802982560921098
HELO_3689;30.54911217515493;30.277437980311642;36.16271305234795;28.627118883494308;25.253860694294644;40.550669764299485;2.7915759149445196;1.840426663826917;2.535164791770846;0.8949546878412605;1.082475587169081;2.9590190147370796;baeS;sensor histidine kinase BaeS;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS14750;T;baeS; sensor histidine kinase BaeS;2.7.13.3;baeS;sensor histidine kinase BaeS;0.012477064414043504;-0.1610159032291545;-0.662342142092708;-0.3972723254593511;-0.4097493898733946
HELO_3690;73.53425803901533;47.56714368663757;56.965376456885735;53.87795262634094;54.8912227427036;66.7640564759793;1.6857393264078384;1.952087192480503;4.795654004012496;4.626970873021806;2.2552937728203517;4.967260398002046;baeR;response regulator/HTH domain transcription regulator BaeR;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS14755;KT;baeR; response regulator/HTH domain transcription regulator BaeR;;baeR;response regulator/HTH domain transcription regulator BaeR;0.6179230395894688;-0.225328824272772;-0.2778985020712348;0.1373834416592068;-0.480539597930262
HELO_3691;41.889288513166754;20.629689106707016;25.92089107799093;28.876080919921776;31.175209030652667;28.748451924701794;0.8106086644284083;0.6186300784067763;3.043900106020061;1.1078771402263043;2.703257073425438;0.4532899059982479;HELO_3691;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS14760;K;;baeR;;HELO_3691;AraC family transcription regulator;0.9876044544828195;-0.1440884304230492;0.11313492696267602;0.5278027892444683;-0.4598016652383512
HELO_3692;37.93055947391511;7.982240473181225;19.810758851208192;27.524505543730143;21.20293530876228;18.690407086816368;1.8135496955143549;0.5213772481857439;2.17847749292889;2.665980858561279;0.9796261652063486;2.570916800098985;HELO_3692;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS14765;E;;;;HELO_3692;LysE family transport protein;2.115755826228569;0.07983663463511892;0.17325748035022048;0.9834101395471517;-1.1323456866814174
HELO_3693;38.006065285143045;22.013305969543584;57.51012882760085;18.791082949416218;18.438279538669306;79.0838526829488;3.2683050013833097;1.612261000099852;8.170186084772899;1.8331847452426557;2.4707607966556377;2.2570499189449897;HELO_3693;uncharacterized protein;;;;;;;;;HELO_3693;uncharacterized protein;0.7612302262812412;-0.4528249864913496;-2.042610847978632;-1.037812906525125;-1.799043132806366
HELO_3694;3.0327908582988576;6.8265979394316725;10.84476254894406;8.431782829153208;12.308527369306402;12.173589123503506;0.22987178314618412;0.4630597080417808;0.7612918384350663;0.5974025008503151;0.8248937398253028;2.2651330819551845;HELO_3694;BCC family transport protein;COG1292;Choline-glycine betaine transporter;BetT;HELO_RS14775;M;;;;HELO_3694;BCC family transport protein;-0.9566067449169822;-0.15339918185857515;0.014702482178381437;-1.7077979649145796;-0.7511912199975974
HELO_3695;39.65770181810735;65.39383391216879;91.72255964811472;87.42359005159649;92.19577563741403;88.68710525561154;1.941122468145465;5.211411815281223;8.177821597558118;9.78840636665006;3.915433381896711;2.5364274513129073;HELO_3695;DOPA dioxygenase family protein;COG3805;Aromatic ring-cleaving dioxygenase;DodA;HELO_RS14780;Q;;;;HELO_3695;DOPA dioxygenase family protein;-0.7075205937334488;0.04801981625887741;0.05536398523815311;-1.1413719079209041;-0.4338513141874554
HELO_3696;7.95814533823986;6.9640028486277785;13.295517123460366;9.480390102252835;23.274120881176657;12.527808321937057;0.7180256153920387;0.3080772862447311;1.6018697348111663;0.6111910780257686;2.188667382290889;0.9112962198620751;fruA;phosphotransferase system component EIIBC%2C fructose-specific;COG1445;Phosphotransferase system fructose-specific component IIB;FrwB;HELO_RS14785;G;fruA; phosphotransferase system component EIIBC, fructose-specific;2.7.1.202;fruA;phosphotransferase system component EIIBC%2C fructose-specific;0.16970633578243977;0.07963468551567532;0.8434909243276922;-0.5946561451995058;-0.7643624809819456
HELO_3697;7.5061439118092395;5.554481117475611;9.355336648429956;6.557834013733204;18.37444993007209;10.031428225387977;0.45057587090598705;0.6927925165615844;0.9670809885106344;0.5372124217395228;0.6651999283281003;0.8586566773053155;fruK;1-phosphofructokinase;COG1105;1-phosphofructokinase or 6-phosphofructokinase II;FruK;HELO_RS14790;G;fruK; 1-phosphofructokinase;2.7.1.56;fruK;1-phosphofructokinase;0.3760236888412285;-0.09124513112682964;0.8125357637079178;-0.37504241834393515;-0.7510661071851636
HELO_3698;9.342740361169048;7.145152999150437;16.338598182821737;13.411250519192244;28.163385756548323;17.916733111308336;0.08431222872180946;0.45300812054161427;1.0720514938029082;0.8461823969720172;2.63888560062906;1.5588763078638397;fruB;multiphosphoryl transfer protein%2C fructose-specific;COG4668;Mannitol/fructose-specific phosphotransferase system, IIA domain;MtlA2;HELO_RS14795;G;fruB; multiphosphoryl transfer protein, fructose-specific;2.7.3.9,2.7.1.202;fruB;multiphosphoryl transfer protein%2C fructose-specific;0.344604781813866;-0.1256756970417614;0.6244952615868229;-0.8710444735072649;-1.2156492553211309
HELO_3699;45.3942412327309;43.23819146526415;64.48868248924497;68.53637442759201;68.3606547430239;61.60234943072545;2.3149692213965634;1.356362137069647;4.846139131106959;2.852082786535732;11.284953147523607;5.770946042283352;fruR;LacI family transcription regulator FruR;COG1609;DNA-binding transcriptional regulator, LacI/PurR family;PurR;HELO_RS14800;K;fruR; LacI family transcription regulator FruR;;fruR;LacI family transcription regulator FruR;0.06865333251332739;0.06502880529314226;0.14790071551496808;-0.4322710623100292;-0.5009243948233566
HELO_3700;43.718866641060565;47.99695971806894;38.31926343374583;48.416482002182626;38.39018476323063;36.122911431993984;0.49680319445510035;1.8028223414651712;2.051853910635597;2.4254998681630293;1.7935561260125024;0.9290337185025838;HELO_3700;sensor histidine kinase / response regulator;COG2198;HPt (histidine-containing phosphotransfer) domain;HPtr;HELO_RS14805;T;;fruR;;HELO_3700;sensor histidine kinase / response regulator;-0.13180860731901856;0.08292643508997166;0.08552632316885589;0.26857376396203314;0.4003823712810517
HELO_3701;97.77349747588494;88.26377961536103;56.21932966548758;63.138067893176476;53.17950953786727;57.359463310014654;8.04282235455024;6.959265082812796;3.571861655825911;1.9198066815682133;2.1508530121447125;4.0711570031485955;HELO_3701;molybdopterin domain protein;COG3915;Uncharacterized conserved protein;;HELO_RS14810;S;;;;HELO_3701;molybdopterin domain protein;0.14604910074827782;-0.02846401955485156;-0.10721928234310063;0.7591573794718487;0.6131082787235709
HELO_3702;223.2464635197534;194.14267803895783;156.1566086372343;151.756660487657;156.07487034201492;171.37648987114554;14.692460156213084;14.338208657119731;7.046215178689007;12.675226000796856;8.714351803287395;8.39629102529256;HELO_3702;UspA domain protein;COG0589;Nucleotide-binding universal stress protein,  UspA family;UspA;HELO_RS14815;T;;;;HELO_3702;UspA domain protein;0.2005559009543827;-0.13336008059170812;-0.13411063197635276;0.37952221210948967;0.17896631115510697
HELO_3703;188.74707411519262;158.6732890132861;236.89945018065464;225.69188739345302;194.70100648613138;247.4226689809359;11.11867494083282;6.853296670425592;10.123256498848983;15.989192230442221;5.901715691408124;12.88996585431213;HELO_3703;TRAP transporter 4TM/12TM fusion protein;COG4666;TRAP-type uncharacterized transport system, fused permease components;;HELO_RS14820;R;;;;HELO_3703;TRAP transporter 4TM/12TM fusion protein;0.24895464824240765;-0.06244489038853818;-0.3441456521488995;-0.38871918831338537;-0.637673836555793
HELO_3704;963.4047553149958;697.1005425288225;1875.4825096146717;1746.723291449541;2039.902040315513;1922.4833705671124;58.502244856726236;19.115789839692475;68.75060473620107;40.26761145787681;128.5354333857849;262.6658135902407;HELO_3704;TRAP transporter substrate-binding protein;COG2358;TRAP-type uncharacterized transport system, periplasmic component;Imp;HELO_RS14825;R;;;;HELO_3704;TRAP transporter substrate-binding protein;0.46620393198533705;-0.03569051373642296;0.08548558032437725;-0.9960106871471641;-1.4622146191325012
HELO_3705;23.86255749937519;31.381477432483397;59.28656726326571;55.178858537329894;69.76810845816833;58.303365490376365;2.2616101348549056;3.172913771098636;11.014915550257612;2.902641853170208;7.995710082650695;4.629132006899189;ymdB;O-acetyl-ADP-ribose deacetylase;COG2110;O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain;YmdB;HELO_RS14830;J;ymdB; O-acetyl-ADP-ribose deacetylase;3.1.1.106;ymdB;O-acetyl-ADP-ribose deacetylase;-0.38119410376346075;0.023722603558478994;0.25498537777289165;-1.254139273062811;-0.8729451692993502
HELO_3706;101.69596643932353;40.521654675618734;119.92906427718252;122.35378212188967;138.7168530766471;121.12143061520187;4.617543128343721;2.7558400267696985;3.07226767672351;4.929746802719213;10.873617732092473;7.513493145702921;HELO_3706;TRAP transporter large transmembrane protein (probable substrate (S)-2-acetolactate);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS14835;G;;ymdB;;HELO_3706;TRAP transporter large transmembrane protein (probable substrate (S)-2-acetolactate);1.3064436757796827;-0.01415536968210418;0.194189658070556;-0.24993687704709533;-1.556380552826778
HELO_3707;106.26612916429771;44.329021022600536;45.22878084955505;39.83781472812;51.08746214881535;43.787195852599815;4.968736739878231;3.004719420353921;6.652728322931681;0.8643446659056371;2.8924815556045043;2.819242846250534;HELO_3707;TRAP transporter small transmembrane protein (probable substrate (S)-2-acetolactate);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS14840;G;;;;HELO_3707;TRAP transporter small transmembrane protein (probable substrate (S)-2-acetolactate);1.2426876875435244;0.04570497495866821;0.2178498053370861;1.2600363498051;0.017348662261575498
HELO_3708;314.3604118421393;138.8679266133678;501.1786872942285;484.8268705995938;566.0234690591475;535.779665813432;9.91027832966917;5.547914293249559;12.340940974187536;14.637908957430792;8.13290874346385;35.92903285166652;HELO_3708;TRAP transporter substrate-binding protein (probable substrate (S)-2-acetolactate);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS14845;G;;;;HELO_3708;TRAP transporter substrate-binding protein (probable substrate (S)-2-acetolactate);1.172936392351252;-0.09612921943534403;0.07907842877314941;-0.767328455100337;-1.940264847451589
HELO_3709;1.1949238369256;1.1996713607004916;6.724363038455471;6.324718862036113;2.1134530650438417;7.368639777036528;0.5354305399753113;0.33975108350904876;1.0287421788865914;1.403347994601599;0.31672670066502195;1.7060215758786816;HELO_3709;Tsx domain protein;COG3248;Nucleoside-specific outer membrane channel protein Tsx;Tsx;HELO_RS14850;M;;;;HELO_3709;Tsx domain protein;-0.003117116076924553;-0.11557717757824193;-1.4264776179801157;-1.9308222692673798;-1.9277051531904552
HELO_3710;67.05841091447813;42.40424757126417;78.208880378686;99.09559638763108;81.64746739167443;75.59201832113888;2.69798521051394;1.3379987648103353;2.5720484775267503;6.538792075860327;4.726939290630228;1.2382281721035575;HELO_3710;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS14855;GER;;;;HELO_3710;DMT superfamily transport protein;0.6489372336630241;0.0484681285822095;0.10977655468876524;-0.17042058984088282;-0.819357823503907
HELO_3711;74.572773905809;58.87107234875888;157.9902615756824;143.06026023998504;191.52167355418098;161.90061481595674;4.306091414670963;0.8774928559285203;14.223272049932215;2.3548954567920872;26.232941843670115;8.761567190021085;HELO_3711;YrdC domain protein;COG0009;tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC;TsaC;HELO_RS14860;J;;;;HELO_3711;YrdC domain protein;0.3360074674886331;-0.03505364817458112;0.24102882068075537;-1.108053565726295;-1.4440610332149282
HELO_3712;86.08659015855058;59.951805456700534;105.89649915389036;95.01767822446214;97.8026851003295;102.00030061148432;1.740024233846611;2.1508512480778106;13.499686503586759;3.7568476422515724;11.123596874957062;6.440937881960453;HELO_3712;PHP domain protein;COG0613;5'-3' exoribonuclease TrpH/YciV (RNase AM), contains PHP domain;YciV;HELO_RS14865;F;;;3.1.3.97;HELO_3712;PHP domain protein;0.5147816300046717;0.053566057769988795;-0.06002639329282644;-0.24212605724869096;-0.7569076872533627
HELO_3713;207.91538623868792;146.67864137372234;334.0573176893699;322.5539226642788;351.17654417953736;330.75740518329786;12.268229045876453;18.95014412063484;22.785383116910012;35.872383811277594;27.373312143379756;18.28292917346608;yciI;YciI family protein;COG2350;YciI superfamily enzyme, includes 5-CHQ dehydrochlorinase, contains active-site pHis;YciI;HELO_RS14870;QR;yciI; YciI family protein;;yciI;YciI family protein;0.5004575626555967;0.01427924762123034;0.08617015688027863;-0.667209920278208;-1.1676674829338047
HELO_3714;92.1845060037843;67.06533874758692;87.06758966189216;84.16182583877078;88.15402893028856;93.67913406643002;3.5117760498454778;1.7572518120328673;3.586274000472053;3.6081642911872294;3.85831136588202;8.579812080017485;mnmC;tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC;COG4121;tRNA U34 5-methylaminomethyl-2-thiouridine-forming methyltransferase MnmC;MnmC;HELO_RS14875;J;mnmC; tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC;2.1.1.61,1.5.-.-;mnmC;tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC;0.4531697802566095;-0.1044353302290233;-0.08674651559254443;-0.022956416582216477;-0.47612619683882595
HELO_3715;31.10883080242411;18.89913749629068;20.878520437924724;25.037846188566608;22.63821853236148;21.96930706194871;1.278044254671318;0.686710494132453;0.6625961222829616;1.0101839121213125;1.9554350139382153;2.092306858649986;HELO_3715;response regulator domain protein;COG4565;DNA-binding response regulator DpiB of citrate/malate metabolism;CitB;HELO_RS14880;KT;;mnmC;;HELO_3715;response regulator domain protein;0.6902642320475687;-0.0701921567604975;0.04141397838156902;0.48326279817589946;-0.20700143387166925
HELO_3716;30.449258216831485;22.244970074373736;19.958188288662512;26.045869523106955;20.833072742400166;18.014759472645288;1.69107119308102;1.0332027592912871;2.6209516476216312;2.8423571358811546;2.8952623060722584;2.1259889430857437;HELO_3716;PAS domain protein / sensor histidine kinase;COG3290;Sensor histidine kinase DipB regulating citrate/malate metabolism;CitA;HELO_RS14885;T;;;2.7.13.3;HELO_3716;PAS domain protein / sensor histidine kinase;0.43610742060966246;0.14039432011635444;0.19939549689222158;0.7259062994376615;0.28979887882799904
HELO_3717;1.5541190285013198;0.8879361673238702;1.0999528052997765;1.171725853830882;1.1014870659613736;0.8757893221324856;0.28395905412833533;0.19114975103213472;0.2836012080825286;0.22539709532531396;0.2593439176288087;0.14669181625310274;HELO_3717;CCS family transport protein (probable substrate 2-hydroxycarboxylate);COG3493;Na+/citrate or Na+/malate symporter;CitS;HELO_RS14890;C;;;;HELO_3717;CCS family transport protein (probable substrate 2-hydroxycarboxylate);0.43601577308130024;0.16285910313633345;0.16391277540780835;0.4453279581554491;0.009312185074148882
HELO_3718;96.31752037205938;101.57706952388348;83.22187915333502;88.80370620432143;74.2646031706338;70.42614199437355;9.684546296615418;6.195714536916108;7.239961666325895;14.568855043979454;11.194432409544964;6.145693057148334;HELO_3718;UPF0270 family protein;COG3089;Uncharacterized conserved protein YheU, UPF0270 family;YheU;HELO_RS14895;S;;;;HELO_3718;UPF0270 family protein;-0.07593679501875794;0.23774286736297512;0.07551932926803495;0.4462473633829802;0.5221841584017382
HELO_3719;94.3937046938496;103.93870624504649;99.7132013838414;104.72106568134711;91.35969428682375;99.03214613006776;3.0078196404103816;2.701704885303009;3.73697199010117;2.8478325163164677;4.5695802457017285;3.2936393331773486;ligA;DNA ligase (NAD) LigA;COG0272;NAD-dependent DNA ligase;Lig;HELO_RS14900;L;ligA; DNA ligase (NAD) LigA;6.5.1.2;ligA;DNA ligase (NAD) LigA;-0.1375809418168359;0.009789106637908773;-0.11512839322658674;-0.06849772922681385;0.06908321259002204
HELO_3720;1099.9034178744512;328.2425221546434;445.5166895637597;616.34954655547;446.1332869364382;395.71625832421137;40.768227673021535;25.83214640330424;43.71108300085392;73.36682304024075;56.77626344628059;10.123764040124925;zipA;cell division protein ZipA;COG3115;Cell division protein ZipA, interacts with FtsZ;ZipA;HELO_RS14905;D;zipA; cell division protein ZipA;;zipA;cell division protein ZipA;1.7414653279040344;0.17060657673929747;0.1725974280487481;1.4725084782961435;-0.2689568496078909
HELO_3721;436.59402151918476;193.4493515777087;215.39527647273974;258.24998300484236;201.10037725266272;180.29103763650312;14.128415411912234;10.119655039379285;4.956773401095269;19.328065420233475;13.386862368913507;7.540221885371073;smc;chromosome partition protein Smc;COG1196;Chromosome segregation ATPase Smc;Smc;HELO_RS14910;D;smc; chromosome partition protein Smc;;smc;chromosome partition protein Smc;1.1701986040463588;0.2553614027226123;0.15676440944374725;1.271285422633074;0.10108681858671531
HELO_3722;192.50153600892574;150.8592984473945;101.62099656130005;122.58595351983418;119.02839502819536;101.99733366801632;3.5434551465483244;2.2341475427663346;2.7684481607208458;4.948921034012162;2.817073346897098;4.503164507502549;ccmI;cytochrome c-type biogenesis protein CcmI;COG4235;Cytochrome c-type biogenesis protein CcmH/NrfG;NrfG;HELO_RS14915;OC;ccmI; cytochrome c-type biogenesis protein CcmI;;ccmI;cytochrome c-type biogenesis protein CcmI;0.34960977008008687;-0.005281049439710195;0.22076875321886558;0.909738028196653;0.5601282581165661
HELO_3723;67.03365830755695;78.8793822872626;23.886646651807656;30.068082854572367;31.53868987931322;27.861438887406127;2.3489572774224525;5.8499411631371485;3.2872162679251664;2.4916102514051293;6.225639094743897;2.9437527899704783;ccmH;cytochrome c-type biogenesis protein CcmH;COG3088;Cytochrome c-type biogenesis protein CcmH/NrfF;NrfF;HELO_RS14920;OC;ccmH; cytochrome c-type biogenesis protein CcmH;;ccmH;cytochrome c-type biogenesis protein CcmH;-0.23157450853633854;-0.21377137955593462;0.17301293706399434;1.2371054406271886;1.4686799491635272
HELO_3724;59.14560553808596;64.90328860756289;27.662117751826802;33.28727451552479;44.7789674552196;26.52428222668115;3.043527539921858;3.180392036094646;1.8648514384593138;1.7794365355493367;1.4964500800705045;4.821273345645138;ccmG;thiol:disulfide interchange protein CcmG;COG0526;Thiol-disulfide isomerase or thioredoxin;TrxA;HELO_RS14925;O;ccmG; thiol:disulfide interchange protein CcmG;;ccmG;thiol:disulfide interchange protein CcmG;-0.13189112566476613;0.0584402677049205;0.7339799813321433;1.1277543906434326;1.2596455163081988
HELO_3725;33.25744117775711;42.99409888504792;36.8209991042476;44.70253548782347;52.51707837709301;36.34388614471311;2.068767299351095;1.319055361326074;2.2811832371762155;1.7759703234770146;1.218277886712212;3.2431674114001834;ccmF;cytochrome c-type biogenesis protein CcmF;COG1138;Cytochrome c biogenesis protein CcmF;CcmF;HELO_RS14930;OC;ccmF; cytochrome c-type biogenesis protein CcmF;;ccmF;cytochrome c-type biogenesis protein CcmF;-0.36089262701449165;0.018315407339007272;0.5191272903932287;-0.12445467271571875;0.2364379542987729
HELO_3726;51.536412718603174;62.39202336287767;22.06434249566313;22.112195877824675;25.016227446994364;20.824164535564694;0.9748711579309534;3.838302111773877;1.250279397471129;5.869855477772957;1.5999034564944825;4.409086116732485;ccmE;cytochrome c-type biogenesis protein CcmE;COG2332;Cytochrome c biogenesis protein CcmE;CcmE;HELO_RS14935;OC;ccmE; cytochrome c-type biogenesis protein CcmE;;ccmE;cytochrome c-type biogenesis protein CcmE;-0.27098362303495716;0.07973773930704908;0.25348534914469134;1.2673912678002894;1.5383748908352466
HELO_3727;46.4314150000292;37.66857320861697;2.859858898905507;3.662366001726171;3.3840237114840375;3.7565181216425874;3.100713865625318;6.17456591472274;0.904669597711306;1.5786967222835553;1.291798641930422;1.5991798469374978;ccmD;heme exporter protein CcmD;COG3114;Heme exporter protein D;CcmD;HELO_RS14940;U;ccmD; heme exporter protein CcmD;;ccmD;heme exporter protein CcmD;0.29468137542843476;-0.3013577653689796;-0.11765027333425015;3.31786512858606;3.023183753157625
HELO_3728;28.909087184779963;35.55712036406563;20.221509588484874;21.99385220476726;25.404884681910506;19.457054938826;2.203403766431133;0.5353202240366596;0.5507371543735032;0.8805704896457294;4.034224066165756;3.458196483847384;ccmC;heme exporter protein CcmC;COG0755;ABC-type transport system involved in cytochrome c biogenesis, permease component;CcmC;HELO_RS14945;O;ccmC; heme exporter protein CcmC;;ccmC;heme exporter protein CcmC;-0.28956855197291986;0.05292882059747672;0.3682063755665297;0.5479854153921639;0.8375539673650838
HELO_3729;115.83175996270585;142.3593167654296;58.49413974578825;72.83748678645865;83.87123190504742;58.5630274845808;9.360021542655847;9.130011555674646;5.836724866034627;2.609024665808341;8.18267661697837;6.811938641482068;ccmB;heme exporter protein CcmB;COG2386;ABC-type transport system involved in cytochrome c biogenesis, permease component;CcmB;HELO_RS14950;O;ccmB; heme exporter protein CcmB;;ccmB;heme exporter protein CcmB;-0.2952031518957279;-0.0016695174685743552;0.5108585328597739;0.9719435243409293;1.2671466762366572
HELO_3730;287.80215791833416;320.045840664925;332.00123192331483;384.5235469743953;434.67076535950054;298.23220102887336;19.16303735637169;18.79860370890252;8.691451723453092;35.43613232034378;14.11301371249315;22.602822080589576;ccmA;heme exporter protein CcmA;COG4133;ABC-type transport system involved in cytochrome c biogenesis, ATPase component;CcmA;HELO_RS14955;O;ccmA; heme exporter protein CcmA;7.6.2.5;ccmA;heme exporter protein CcmA;-0.15269778584588778;0.15426207935770897;0.541972872779592;-0.05118391310932857;0.10151387273655921
HELO_3731;20.88244235323378;25.848898975875837;33.61626549130679;32.552778507879395;35.59401238229072;31.642023278646104;1.5435613821610215;0.756630203577059;3.537850570351053;1.508548140236319;1.7982356369602004;1.1138843403361385;HELO_3731;homolog to LexA repressor;COG1974;SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase);LexA;HELO_RS14960;KT;;ccmA;3.4.21.88;HELO_3731;homolog to LexA repressor;-0.29508915728448937;0.0847196068515812;0.16487712601103421;-0.5769567140298291;-0.2818675567453397
HELO_3732;148.18640886529215;89.13728499021522;104.79791079566864;111.80534043093037;126.554090470156;123.19854978535159;3.7065539984439644;2.1368610493307574;5.486421993043086;3.965611686361588;8.799260882932133;3.683909314419455;HELO_3732;impact domain protein;COG1739;Putative translation regulator, IMPACT (imprinted ancient) protein family;YIH1;HELO_RS14965;R;;;;HELO_3732;impact domain protein;0.7269202089670053;-0.23133718925150681;0.038460836859905534;0.264467781707471;-0.4624524272595343
HELO_3733;24.055211114341784;70.76466039273186;26.948642820351555;24.347578275481002;25.335173349993173;30.415159006705952;1.184662587295966;2.652568627268174;1.115899922971992;0.35166137390445934;0.7294523073111288;3.046597034979257;HELO_3733;acyltransferase domain protein;COG3176;Putative hemolysin;;HELO_RS14970;R;;;;HELO_3733;acyltransferase domain protein;-1.518162887911406;-0.16868265442096497;-0.25446992625913545;-0.32635018833475726;1.1918126995766487
HELO_3734;397.6482808893468;723.3244332839595;707.2747946118465;414.0657818195314;561.3411324361136;812.8011136058409;24.286809481960432;10.640486979745413;73.76977662582618;38.562522543572705;35.24012573397153;19.550819720034735;oadB;oxaloacetate decarboxylase beta subunit;COG1883;Na+-transporting oxaloacetate/methylmalonyl-CoA decarboxylase, beta subunit;OadB;HELO_RS14975;C;oadB; oxaloacetate decarboxylase beta subunit;7.2.4.1;oadB;oxaloacetate decarboxylase beta subunit;-0.8615195941404519;-0.20036705261131793;-0.5332306779459941;-1.029559806885544;-0.16804021274509218
HELO_3735;405.0456291084806;920.8287659842869;875.5615412873212;719.1125467050183;625.9667825049772;960.8537737850814;43.326602029585125;52.75123750044909;64.17866531002818;34.70661272868348;24.029373029191344;129.45448147379076;oadA;oxaloacetate decarboxylase alpha subunit;COG5016;Pyruvate/oxaloacetate carboxyltransferase;OadA1;HELO_RS14980;C;oadA; oxaloacetate decarboxylase alpha subunit;7.2.4.2;oadA;oxaloacetate decarboxylase alpha subunit;-1.182856929753445;-0.13396220165363815;-0.617428575119499;-1.2441757259397832;-0.061318796186338176
HELO_3736;443.3512401892144;542.0772059774766;530.8706019262887;517.7836491129601;164.9104721990519;635.92730724617;34.88768544061807;65.09531768646036;5.636633639490359;32.31299357737052;6.717150850691512;80.29647901197079;oadC;oxaloacetate decarboxylase gamma subunit;COG3630;Na+-transporting oxaloacetate/methylmalonyl-CoA decarboxylase, gamma subunit;OadG;HELO_RS14985;C;oadC; oxaloacetate decarboxylase gamma subunit;;oadC;oxaloacetate decarboxylase gamma subunit;-0.28945679701938687;-0.2600534294419514;-1.9407237750772381;-0.519428211793441;-0.22997141477405414
HELO_3737;76.22206884684236;39.354915803104596;55.581042740675606;66.48566020936407;44.92748390556894;53.774460648604936;3.580753110699073;1.3210522733017143;1.6023913293190806;3.8767717022703727;4.848073572608;3.5425074450575185;dusC;tRNA-dihydrouridine(16) synthase DusC;COG0042;tRNA-dihydrouridine synthase;DusA;HELO_RS14990;J;dusC; tRNA-dihydrouridine(16) synthase DusC;1.-.-.-;dusC;tRNA-dihydrouridine(16) synthase DusC;0.9362687808637116;0.046815391223972824;-0.2541456243827751;0.49550983245856717;-0.4407589484051444
HELO_3738;5.062223203161315;8.488432160795803;5.331038603030533;25.193895030378332;7.653936016053837;5.356874776771996;0.9873869818945928;0.09044529581559481;0.06437889017891733;1.6954140064672791;0.4533550332429474;1.3773774115886834;HELO_3738;HAE1 family transport protein;COG0841;Multidrug efflux pump subunit AcrB;AcrB;HELO_RS14995;V;;dusC;;HELO_3738;HAE1 family transport protein;-0.6463227492175432;-0.005875476941644031;0.4450387848009898;-0.06847069800184657;0.5778520512156966
HELO_3739;8.473399772247284;17.974704536812897;12.80534640343816;52.45263546952111;12.76263770519949;10.094435590376689;0.4544589632941432;0.487403387521416;1.3894486004496889;5.874704704796794;0.4710385465723395;2.211843922077153;HELO_3739;RND family transport protein MFP component;COG0845;Multidrug efflux pump subunit AcrA (membrane-fusion protein);AcrA;HELO_RS15000;VM;;;;HELO_3739;RND family transport protein MFP component;-1.0021232491841001;0.3153908135866632;0.3109207242103196;-0.22788210305063528;0.7742411461334648
HELO_3740;48.339925998996286;20.552099400490977;66.25295989144236;86.23117715452732;91.2094357448755;62.78295484444103;0.9107103561227655;0.7592285693550309;6.966407025328546;3.0509024269783196;22.64458321783347;6.279447201536484;HELO_3740;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS15005;K;;;;HELO_3740;LysR family transcription regulator;1.1949271420713359;0.07642682975090764;0.5317434542350306;-0.3704153823697798;-1.5653425244411157
HELO_3741;1646.7484141641892;3262.0448937991373;3516.4174184212666;3259.5897630005907;3187.227582665198;3511.436560296855;50.2057671986423;110.5851598504249;29.22717502265014;138.19291902295657;221.41446571857543;306.37217795913193;csrA;RNA-binding regulator protein CsrA;COG1551;sRNA-binding carbon storage regulator CsrA;CsrA;HELO_RS15025;T;csrA; RNA-binding regulator protein CsrA;;csrA;RNA-binding regulator protein CsrA;-0.9857228545346644;0.002044384005607469;-0.1397175526673351;-1.0919761864062458;-0.10625333187158148
HELO_3742;424.58298788001645;596.2278438851398;957.4362437888389;837.4095183980477;1089.9432409744174;951.3985641071707;10.387091445924215;16.134852252426175;74.16078559313404;52.854329516820506;121.8405628387385;51.44414224797132;lysC;aspartate kinase;COG0527;Aspartate kinase;MetL1;HELO_RS15030;E;lysC; aspartate kinase;2.7.2.4;lysC;aspartate kinase;-0.4888409460404848;0.009117019940529048;0.1959386931998779;-1.162124963361208;-0.6732840173207233
HELO_3743;338.9841762158798;378.08842924981326;363.37063065759827;364.2804721389782;367.7630162870796;358.12602403677687;8.069680944485437;5.993188174426675;11.825023817004618;12.374468844771332;18.139847478506354;18.80203118479011;alaS;alanine--tRNA ligase;COG0013;Alanyl-tRNA synthetase;AlaS;HELO_RS15035;J;alaS; alanine--tRNA ligase;6.1.1.7;alaS;alanine--tRNA ligase;-0.15706682143934358;0.020916476806956297;0.03820377173378908;-0.0790226005720509;0.07804422086729268
HELO_3744;248.25823636034465;323.3109086626898;181.83044446303776;165.78424584025998;174.97696575407372;178.48042990870525;17.621471647472784;21.04616155747095;7.294012117826582;6.470696769615338;18.36774385977089;23.74799986151764;recX;RecX family transcription regulator RecX;COG2137;SOS response regulatory protein OraA/RecX, interacts with RecA;RecX;HELO_RS15040;O;recX; RecX family transcription regulator RecX;;recX;RecX family transcription regulator RecX;-0.3797363746469111;0.02667977951557443;-0.028439943035856174;0.47381463226815956;0.8535510069150707
HELO_3745;352.1401239716741;541.3903171757064;530.352138964304;431.588332266193;476.5999484720823;528.5237423513685;19.203583481431895;11.256412334397364;24.07474164994192;6.133973336754183;14.450364662404397;19.504533667312874;recA;protein RecA;COG0468;RecA/RadA recombinase;RecA;HELO_RS15045;L;recA; protein RecA;;recA;protein RecA;-0.6190906733193042;0.0049729122595696396;-0.14889269109372805;-0.5844546218445892;0.034636051474715046
HELO_3746;265.9502103718805;104.16201583147858;279.2166290710129;316.6810678906808;274.4389173963125;311.4135517798591;19.962218619087068;6.265165846081275;12.51769038576059;11.32704048923768;4.088781995048547;19.71499642793774;pncC;nicotinamide-nucleotide amidohydrolase PncC;COG1546;Nicotinamide mononucleotide (NMN) deamidase PncC;PncC;HELO_RS15050;H;pncC; nicotinamide-nucleotide amidohydrolase PncC;3.5.1.42;pncC;nicotinamide-nucleotide amidohydrolase PncC;1.3439569838367973;-0.1569144625581096;-0.1817246200573681;-0.22688634969489208;-1.5708433335316894
HELO_3747;90.95219053574544;106.80713986677573;140.44690134851663;132.28275398023388;120.89808491637449;141.44840896032028;5.2850148176754;2.8497674621347047;4.350981591214713;3.645166273006656;6.652928104426148;6.666091814069052;mutS;DNA mismatch repair protein MutS;COG0249;DNA mismatch repair ATPase MutS;MutS;HELO_RS15055;L;mutS; DNA mismatch repair protein MutS;;mutS;DNA mismatch repair protein MutS;-0.22949687943395158;-0.010178935729499905;-0.2247640473213739;-0.6314836591171993;-0.4019867796832477
HELO_3748;328.31353370768426;463.1930959728593;210.8398313995964;127.76842113165831;163.17769242876363;163.4304353128478;25.862078278689616;25.490064770893877;15.398287630390307;44.13964389362232;14.378089438697645;16.63657178284687;HELO_3748;ferredoxin;COG1146;NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit;PreA;HELO_RS15060;F;;mutS;;HELO_3748;ferredoxin;-0.4952632621872173;0.3654965191233721;-0.002219245031430006;1.0019844432790022;1.4972477054662194
HELO_3749;651.6123653394894;589.5156657591087;818.1766106339888;723.24760845321;1108.3527582611712;768.4087983318256;18.30001612372054;15.912770036908231;34.278816981270886;38.57752028469486;76.29342787728194;10.301474015028596;eno;enolase;COG0148;Enolase;Eno;HELO_RS15065;G;eno; enolase;4.2.1.11;eno;enolase;0.14425098976826867;0.09042419646923072;0.527895962452666;-0.2375240041338973;-0.38177499390216596
HELO_3750;255.69364323725992;371.3609678381584;324.5081344548615;352.28421454721644;377.2471573312355;344.12310074894117;16.400438556661868;25.076563683123087;5.670448700663546;20.228312285541907;10.871487513644736;11.468382750012921;kdsA;2-dehydro-3-deoxyphosphooctonate aldolase;COG2877;3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase;KdsA;HELO_RS15070;M;kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase;2.5.1.55;kdsA;2-dehydro-3-deoxyphosphooctonate aldolase;-0.5366542831006189;-0.08441744670323104;0.13221819656741296;-0.42706347407481005;0.10959080902580887
HELO_3751;264.9811580643247;341.61712347339426;404.0051131834725;443.402513507861;464.05292312885655;410.6820116373699;8.98356631206132;26.010032340781503;35.163301824976024;18.905782460561603;51.33846684148812;35.4980282516549;pyrG;CTP synthase;COG0504;CTP synthase (UTP-ammonia lyase);PyrG;HELO_RS15075;F;pyrG; CTP synthase;6.3.4.2;pyrG;CTP synthase;-0.3652732071391753;-0.023590289651489016;0.17586449282134886;-0.6302063620177698;-0.2649331548785945
HELO_3752;291.34824858652604;515.835640625375;594.9563177221927;595.0738150930378;485.91531577413645;528.3822158953731;22.867811295580637;36.80754367090105;15.882309513208092;25.128336318671753;39.39278487241921;35.82409374845526;gltD;glutamate synthase (NADP) small subunit;COG0493;NADPH-dependent glutamate synthase beta chain or related oxidoreductase;GltD;HELO_RS15080;ER;gltD; glutamate synthase (NADP) small subunit;1.4.1.13;gltD;glutamate synthase (NADP) small subunit;-0.8220176123279224;0.17089685856703873;-0.1206388487879888;-0.8566217812669947;-0.034604168939072366
HELO_3753;238.58926934455926;561.0440322971175;454.38526250232127;400.27591601084754;391.069741658292;408.0115365887391;32.863003918436966;21.364941162050236;43.53371895917564;37.243618174776266;16.399556660710246;26.27178579280141;gltB;glutamate synthase (NADP) large subunit;COG0070;Glutamate synthase domain 3;GltB3;HELO_RS15085;E;gltB; glutamate synthase (NADP) large subunit;1.4.1.13;gltB;glutamate synthase (NADP) large subunit;-1.230119865578435;0.1549460662897264;-0.06103123159171453;-0.7715782418680339;0.45854162371040097
HELO_3754;254.75323309190034;103.57512351594353;193.99029785772518;173.3659678051387;210.55192326077625;195.1966408786055;13.465957980513254;3.724324959505915;19.454051985546382;11.231497666440136;15.284675632766957;9.495988668906568;aroB;3-dehydroquinate synthase;COG0337;3-dehydroquinate synthetase;AroB;HELO_RS15090;E;aroB; 3-dehydroquinate synthase;4.2.3.4;aroB;3-dehydroquinate synthase;1.2902127758628703;-0.008897999592793582;0.10871146048038227;0.38245213674199796;-0.9077606391208723
HELO_3755;159.42299162700613;59.24111907350338;89.05313189694436;73.50840624161708;88.89698039270705;94.27568747369274;9.634310118270282;5.689857631824687;1.1122220184545633;4.515175687773594;6.220903797651855;11.584389176178972;aroK;shikimate kinase;COG0703;Shikimate kinase;AroK;HELO_RS15095;E;aroK; shikimate kinase;2.7.1.71;aroK;shikimate kinase;1.413060446200026;-0.08133166150355375;-0.08383545607715259;0.7517009037652018;-0.6613595424348242
HELO_3756;4.372472718530685;3.151395037445393;5.571779833881105;6.871616964459129;5.382555606028767;4.803474725084669;1.0084760028643258;0.33088775491447053;0.5228492096078952;0.8243179938886007;0.2665536433151928;0.2977992129714067;pilQ;fimbrial assembly protein PilQ;COG4796;Type II secretory pathway, component HofQ;HofQ;HELO_RS15100;U;pilQ; fimbrial assembly protein PilQ;;pilQ;fimbrial assembly protein PilQ;0.37199002955237725;0.17936720190590982;0.1372172553341242;-0.11133069473239132;-0.4833207242847686
HELO_3757;10.041044589792897;5.301818424863143;3.6597484271299723;6.592481678064126;4.614552476711037;2.426981199514403;0.5058023521936793;0.6545771478050163;1.1245971540589357;0.3066984278657236;0.5744662907059724;0.11777906045906704;pilP;fimbrial assembly protein PilP;COG3168;Type IV pilus assembly protein PilP;PilP;HELO_RS15105;NW;pilP; fimbrial assembly protein PilP;;pilP;fimbrial assembly protein PilP;0.8090365800003165;0.4433137908020859;0.7122327560216779;1.687866489163802;0.8788299091634855
HELO_3758;8.789506790806835;5.655868899287479;2.5546172449569515;3.437439156296947;2.5901040273319835;2.533246847038397;1.0699841494846012;0.07405193750502484;0.42857089789385033;1.2296645063178913;0.546254005076555;0.931418356484632;pilO;fimbrial assembly protein PilO;COG3167;Type IV pilus assembly protein PilO;PilO;HELO_RS15110;NW;pilO; fimbrial assembly protein PilO;;pilO;fimbrial assembly protein PilO;0.5566091596629299;0.008699675988047773;0.023031103066897485;1.470241631333398;0.913632471670468
HELO_3759;18.434220938558003;9.137249610712944;6.584730891047289;9.335715728686845;6.6196678226326595;5.201633400514493;0.6059371618842884;1.1686939901121498;1.5651106415787492;2.5847059620033668;1.3004035545435781;0.4641610084752657;pilN;fimbrial assembly protein PilN;COG3166;Type IV pilus assembly protein PilN;PilN;HELO_RS15115;NW;pilN; fimbrial assembly protein PilN;;pilN;fimbrial assembly protein PilN;0.9389329949586345;0.2904497481495558;0.29707985929052505;1.6478791243748283;0.7089461294161938
HELO_3760;11.551631101748209;4.590646895277562;9.821795544205225;17.595724633030716;14.383501226209413;9.474434666530858;0.35174505853597704;0.33550292143087723;1.6983326786258668;1.89106808908634;0.5789430573346477;1.4739605444044193;pilM;fimbrial assembly protein PilM;COG4972;Type IV pilus assembly protein, ATPase PilM;PilM;HELO_RS15120;NW;pilM; fimbrial assembly protein PilM;;pilM;fimbrial assembly protein PilM;1.1667877240895814;0.047067510018621306;0.5545115126741424;0.26100247668001586;-0.9057852474095656
HELO_3761;256.0653895177533;83.25730853342213;156.81424914448962;147.95259493233;148.4491804637764;158.15239372236536;9.82180888429476;3.333001274758831;9.588904632401194;7.632628190705546;12.531700550130065;10.325155057270042;HELO_3761;peptidoglycan transglycosylase / transpeptidase;COG5009;Membrane carboxypeptidase/penicillin-binding protein;MrcA;HELO_RS15125;M;;pilM;2.4.1.129,3.4.16.4;HELO_3761;peptidoglycan transglycosylase / transpeptidase;1.6092616461503466;-0.012181382863586165;-0.09075387019428494;0.6917265273775799;-0.9175351187727667
HELO_3762;101.39161706637198;47.83602744015874;33.11238944687077;33.579970445197596;27.708493271938767;33.80325089965149;4.876253187545859;2.628212133889446;2.352006502334963;0.8546512231354138;2.4671470096221806;1.823355072093501;HELO_3762;DUF481 domain protein;COG3137;Putative salt-induced outer membrane protein YdiY;YdiY;HELO_RS15130;M;;;;HELO_3762;DUF481 domain protein;1.0680798504868196;-0.02892625757760925;-0.27774445697410677;1.556803628231405;0.4887237777445854
HELO_3763;171.59377734992665;230.81195951823375;415.25311919024307;338.8785260344847;595.3870378448568;414.9222232913327;6.716395482842169;4.901735511025866;38.86538309300415;15.22304963955288;84.27748407892518;16.6536804777025;maeB;malic enzyme (NADP);COG0281;Malic enzyme;SfcA;HELO_RS15135;C;maeB; malic enzyme (NADP);1.1.1.40;maeB;malic enzyme (NADP);-0.4255745481010962;0.0011473108447166425;0.5199351295462407;-1.2689333212944902;-0.843358773193394
HELO_3764;1854.3932672752796;1615.9977938192685;1698.9594440625053;1260.523057398769;855.304977812188;1162.7407929589056;221.48473501093886;256.77882494810143;117.39895212165041;342.7021669086935;105.43211874137167;148.47948009332293;rpmE;50S ribosomal protein L31;COG0254;Ribosomal protein L31;RpmE;HELO_RS15140;J;rpmE; 50S ribosomal protein L31;;rpmE;50S ribosomal protein L31;0.19840730099075365;0.5467305745774329;-0.4425731366385328;0.672955257619881;0.4745479566291273
HELO_3765;88.55165374623387;55.91732348137438;111.90794322907999;101.15261647649743;92.56796780874117;115.05034497796738;3.893230658059145;3.8593294524043706;7.387652706305486;4.042218585940559;7.164577226225569;7.658485313193164;priA;primosomal protein N';COG1198;Primosomal protein N' (replication factor Y) - superfamily II helicase;PriA;HELO_RS15145;L;priA; primosomal protein N';3.6.4.-;priA;primosomal protein N';0.6538522534452254;-0.039603826066072934;-0.31066418615866276;-0.37395883157524246;-1.0278110850204678
HELO_3766;305.3360880903227;375.84931389330126;436.46508676419666;406.33155701124105;331.1398228752617;433.7055083589221;13.296757973941048;1.8724663676218103;9.425076124582732;23.72552924498299;21.97832728348043;13.009317502942494;argS;arginine--tRNA ligase;COG0018;Arginyl-tRNA synthetase;ArgS;HELO_RS15150;J;argS; arginine--tRNA ligase;6.1.1.19;argS;arginine--tRNA ligase;-0.29887243162323784;0.009129506057869108;-0.3882476674508002;-0.5049230423758537;-0.20605061075261588
HELO_3767;161.631678508757;161.37356007090838;179.72981530688628;149.60236327439208;155.16658526829085;182.17812184347244;10.46763292120626;7.086579646503755;8.534654382569407;8.288368949400077;2.8790810495696304;16.276713323765673;HELO_3767;uncharacterized protein;COG3087;Cell division protein FtsN;FtsN;HELO_RS15155;D;;argS;;HELO_3767;uncharacterized protein;0.002291570869244808;-0.019412673549806136;-0.23016140806534224;-0.17163890047968877;-0.17393047134893358
HELO_3768;238.74732567640868;286.4044599796892;340.88449247213134;641.3004780003398;277.9662744721886;347.5999727833455;31.01585622225024;12.100936821187135;19.577704076977216;43.29493811677875;19.028755465064904;9.663846544368285;hslV;ATP-dependent HslUV protease proteolytic subunit;COG5405;ATP-dependent protease HslVU (ClpYQ), peptidase subunit;HslV;HELO_RS15160;O;hslV; ATP-dependent HslUV protease proteolytic subunit;3.4.25.2;hslV;ATP-dependent HslUV protease proteolytic subunit;-0.26156772747978163;-0.028063471729669942;-0.3214817383300179;-0.5400577344084239;-0.27849000692864223
HELO_3769;249.79705038138854;289.2662982559993;372.724040380728;691.6250956666346;318.4766734727628;388.7844242135522;36.316816539763174;8.375480233002678;27.518410664645156;26.9401656215198;18.742252669486145;27.059370832608252;hslU;ATP-dependent HslUV protease ATP-binding subunit HslU;COG1220;ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU;HslU;HELO_RS15165;O;hslU; ATP-dependent HslUV protease ATP-binding subunit HslU;;hslU;ATP-dependent HslUV protease ATP-binding subunit HslU;-0.21085669497933157;-0.06070307134240771;-0.28696584473100195;-0.6361560609156394;-0.4252993659363078
HELO_3770;133.36227100095306;146.8087100160197;148.26572983894135;272.12980430803555;118.27620494873709;143.65980797929197;14.55692732808348;9.703896976424856;10.69992071301536;2.862196827031339;4.843771927778989;1.6765225224943232;HELO_3770;DUF971 domain protein;COG3536;Uncharacterized conserved protein, DUF971 family;;HELO_RS15170;S;;hslU;;HELO_3770;DUF971 domain protein;-0.13760320115081282;0.045218831046397234;-0.27835788100002645;-0.1065360563208424;0.031067144829970417
HELO_3771;176.97661469578796;174.98489984875832;180.9417763570102;173.43808982060577;160.45949312076675;188.023152476842;8.247366542275273;9.256678672341543;5.10216204383065;4.155716972887135;5.735359742629277;1.9882475000506927;ubiE;ubiquinone/menaquinone biosynthesis methyltransferase UbiE;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS15175;H;ubiE; ubiquinone/menaquinone biosynthesis methyltransferase UbiE;2.1.1.163,2.1.1.201;ubiE;ubiquinone/menaquinone biosynthesis methyltransferase UbiE;0.0162360445512002;-0.05508610975731543;-0.2273906859059851;-0.086875263401196;-0.1031113079523962
HELO_3772;176.96341707465504;145.0243864242481;93.86901345777203;85.83201875098071;89.1526023051461;98.80339596960692;15.066664441693884;4.956436813438296;6.009464192684547;2.0545838506811487;0.9884470347832172;5.767157007497136;ubiJ;ubiquinone biosynthesis protein UbiJ;COG3165;Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain;UbiJ;HELO_RS15180;H;ubiJ; ubiquinone biosynthesis protein UbiJ;;ubiJ;ubiquinone biosynthesis protein UbiJ;0.2853713822998518;-0.07315196172833982;-0.1467197699401055;0.8344198935639398;0.5490485112640879
HELO_3773;79.4025756060857;49.67527025566758;51.306394369576516;46.43100278114367;53.73425863033992;50.39471176526905;3.6670986637149356;4.608537023883317;1.0680684594389238;2.784813568822415;1.5421381607322573;4.729631356088971;ubiB;probable ubiquinone biosynthesis-associated protein kinase UbiB;COG0661;Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family;AarF;HELO_RS15185;TH;ubiB; probable ubiquinone biosynthesis-associated protein kinase UbiB;;ubiB;probable ubiquinone biosynthesis-associated protein kinase UbiB;0.6659598395254989;0.025367402691774288;0.09082418899933398;0.6456217956305377;-0.02033804389496119
HELO_3774;136.42610955581972;75.29342593562343;116.74112480540045;108.1433473774919;96.41834768695286;112.60017047854119;15.164320598467434;5.518416364199106;13.534861011330275;6.351248510923594;10.318696196665169;11.199585076057566;hisE;phosphoribosyl-ATP pyrophosphatase;COG0140;Phosphoribosyl-ATP pyrophosphohydrolase;HisI2;HELO_RS15190;E;hisE; phosphoribosyl-ATP pyrophosphatase;3.6.1.31;hisE;phosphoribosyl-ATP pyrophosphatase;0.8490254743589345;0.05165331531327677;-0.2216995809397604;0.27469112762433223;-0.5743343467346023
HELO_3775;1307.2410687068514;700.3056278419716;313.5257746660512;246.1978370307911;263.15467069906;347.8860610023956;100.19060917948751;38.35214549147285;54.4998520704605;52.453084648807966;66.52860475973027;86.4466370549847;tatA;twin arginine translocation system protein TatA;COG1826;Twin-arginine protein secretion pathway components TatA and TatB;TatA;HELO_RS15195;U;tatA; twin arginine translocation system protein TatA;;tatA;twin arginine translocation system protein TatA;0.8995131992642911;-0.149577711384266;-0.40137303949217795;1.9068005457863801;1.007287346522089
HELO_3776;560.9981389917263;209.3339960326971;184.45711376113184;144.39617191633286;169.58063284351863;205.25855581782852;5.923310236013111;21.939983850130382;24.40226650493998;5.372985933911402;5.64396126760588;8.924394703380873;tatB;twin arginine translocation system protein TatB;COG1826;Twin-arginine protein secretion pathway components TatA and TatB;TatA;HELO_RS15200;U;tatB; twin arginine translocation system protein TatB;;tatB;twin arginine translocation system protein TatB;1.4178833031007647;-0.15336835730277443;-0.27400010791150375;1.4461113880147796;0.02822808491401485
HELO_3777;212.51309101628624;77.30239053591639;144.41751685268818;147.9671353827351;131.9516068865218;143.01503915363958;5.419912873714564;4.0765111576202155;4.275329573512208;2.5349174059161252;4.979502584050373;3.229936450368318;tatC;twin arginine translocation system protein TatC;COG0805;Twin-arginine protein secretion pathway component TatC;TatC;HELO_RS15205;U;tatC; twin arginine translocation system protein TatC;;tatC;twin arginine translocation system protein TatC;1.447196269646386;0.013981588564538683;-0.11531826272704127;0.5681050509600665;-0.8790912186863196
HELO_3778;305.4429509549411;132.12461306696028;484.2009959578859;486.5855841304179;500.2238741008887;480.99084555267035;18.206894318312155;6.25410408694109;57.40904798019183;4.068605932858311;89.17550987946842;42.17715710361272;elbB;probable isoprenoid biosynthesis protein ElbB;COG3155;Glyoxalase ElbB, DJ-1 superfamily;ElbB;HELO_RS15210;V;elbB; probable isoprenoid biosynthesis protein ElbB;;elbB;probable isoprenoid biosynthesis protein ElbB;1.20284118706991;0.009576766216451205;0.05644938856331727;-0.6533872264703966;-1.8562284135403067
HELO_3779;113.75202617128603;93.8921603676593;146.9923185733692;144.5511503402698;188.5941731923792;145.99945737280504;2.637224187903695;1.361200103068409;8.4670536626496;6.015308293605789;6.206011550729658;9.347481025658801;hemB;porphobilinogen synthase;COG0113;Delta-aminolevulinic acid dehydratase, porphobilinogen synthase;HemB;HELO_RS15215;H;hemB; porphobilinogen synthase;4.2.1.24;hemB;porphobilinogen synthase;0.2741588202043648;0.009711466257419588;0.3671037969237023;-0.3572912021073522;-0.631450022311717
HELO_3780;37.11783346966731;47.601412194722705;41.492305435522105;42.192267674558515;49.34333588711447;43.14873576327813;3.3202735626780777;0.9473587755018698;1.7585320711919596;1.25222942801328;2.018035135737054;3.643638436128908;ppk;polyphosphate kinase;COG0855;Polyphosphate kinase;Ppk;HELO_RS15220;P;ppk; polyphosphate kinase;2.7.4.1;ppk;polyphosphate kinase;-0.35053211224281533;-0.055170505941608994;0.18942869092351167;-0.2119060035647058;0.13862610867810954
HELO_3781;99.73000449458443;148.73992948435176;242.56814925352708;262.73589903128595;220.92052217065827;231.0998898909552;8.888666705761768;11.178078016852982;28.372333373001037;27.08005251994836;16.855242414266037;15.69277390746097;aroF2;phospho-2-dehydro-3-deoxyheptonate aldolase;COG0722;3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase;AroG1;HELO_RS15225;E;aroF2; phospho-2-dehydro-3-deoxyheptonate aldolase;2.5.1.54;aroF2;phospho-2-dehydro-3-deoxyheptonate aldolase;-0.5719654965441379;0.06957964999676225;-0.06470275087727995;-1.2042523546410298;-0.6322868580968919
HELO_3782;143.52779053375855;199.96930496741007;135.4454272012554;123.07293331124806;131.22838184080055;137.11722180452378;5.039672602245301;7.801906639738027;6.917486519682558;7.091881872308285;8.378314739203175;7.080276580812711;HELO_3782;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS15230;I;;aroF2;1.5.1.50,1.5.1.3;HELO_3782;probable oxidoreductase (short-chain dehydrogenase family);-0.47562824021344774;-0.017569174831144174;-0.06286134625676887;0.06545370796760608;0.5410819481810538
HELO_3783;175.79956419803537;303.76532529545517;233.56752954741344;214.02564232660373;236.18998728539609;258.57598369773353;4.616248086789109;5.491777602306118;10.909851781992446;9.553758469445087;4.118867023084701;9.40393202800222;HELO_3783;oxidoreductase domain protein;COG0543;NAD(P)H-flavin reductase;Mcr1;HELO_RS15235;CH;;;1.17.1.1;HELO_3783;oxidoreductase domain protein;-0.7855840508359542;-0.14615359011354556;-0.130113800135792;-0.5540421909561477;0.23154185987980647
HELO_3784;184.4749929194917;325.6648945076308;277.58157346696737;279.86059685205055;238.26272393457995;288.4953645466909;8.229983176408854;1.6698241011333708;11.987536316067589;7.323445927659623;9.360640047130051;3.4824265070476144;ubiD;3-octaprenyl-4-hydroxybenzoate carboxy-lyase;COG0043;3-polyprenyl-4-hydroxybenzoate decarboxylase;UbiD;HELO_RS15240;H;ubiD; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase;4.1.1.98;ubiD;3-octaprenyl-4-hydroxybenzoate carboxy-lyase;-0.8165867365244424;-0.05544041239867781;-0.2749445987701762;-0.6423155623255639;0.1742711741988785
HELO_3785;784.6380800615821;841.185490881126;819.9587600776385;785.8168090601204;781.7230300515263;833.2660388946196;36.10513503074693;51.13629386446168;76.18649254276158;3.7548696556150905;69.90837581977208;46.720059303177486;rho;transcription termination factor Rho;COG1158;Transcription termination factor Rho;Rho;HELO_RS15245;K;rho; transcription termination factor Rho;;rho;transcription termination factor Rho;-0.10027316194772773;-0.023197766019743327;-0.0920056238091096;-0.08664265859762743;0.013630503350100298
HELO_3786;320.724240238006;144.92254909216317;397.477793128355;327.15366673633;311.4899163267423;382.19364673447853;18.22501373322429;4.925152286083109;31.493543505882556;16.917309492232125;35.22987292884412;30.731337458431387;ppx;exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase;COG0248;Exopolyphosphatase/pppGpp-phosphohydrolase;GppA;HELO_RS15250;TF;ppx; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;3.6.1.11,3.6.1.40;ppx;exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase;1.1406218026180364;0.056425684423031086;-0.2942640052148082;-0.25224900210123025;-1.3928708047192666
HELO_3787;137.4333331996022;167.72264673199757;120.16361325836867;132.55540236556854;122.39915034948642;122.06922460820515;3.6971303081038753;2.4983535230337566;7.297447019590548;10.242978132925026;4.3407632765769835;10.981506154876701;tilS;tRNA(Ile)-lysidine synthase;COG0037;tRNA(Ile)-lysidine synthase TilS/MesJ;TilS;HELO_RS15255;J;tilS; tRNA(Ile)-lysidine synthase;6.3.4.19;tilS;tRNA(Ile)-lysidine synthase;-0.2854622621586005;-0.02251353142576029;0.003862422634886009;0.1697213312703143;0.4551835934289148
HELO_3788;422.4996447171381;376.2823173132678;416.97481438479525;400.23943165469865;453.47174922449045;444.74596022716355;2.54618610339818;7.7012102213130005;21.190000904619687;21.343482081764932;31.15299700909202;13.6941242744403;accA;acetyl-CoA carboxylase carboxyltransferase subunit alpha;COG0825;Acetyl-CoA carboxylase alpha subunit;AccA;HELO_RS15260;I;accA; acetyl-CoA carboxylase carboxyltransferase subunit alpha;6.4.1.2,2.1.3.15;accA;acetyl-CoA carboxylase carboxyltransferase subunit alpha;0.1667162745868236;-0.09280570937613497;0.02796889386840462;-0.07386096358774275;-0.24057723817456633
HELO_3789;194.4381680872104;139.1533386660745;127.81773907720999;105.72967440095636;120.74794876275729;130.4292064646602;0.9777364980836086;1.1427632778835477;6.071881794970789;2.671498886678515;5.741936066281692;6.304404828550502;dnaE;DNA polymerase 3 alpha subunit;COG0587;DNA polymerase III, alpha subunit;DnaE;HELO_RS15265;L;dnaE; DNA polymerase 3 alpha subunit;2.7.7.7;dnaE;DNA polymerase 3 alpha subunit;0.4797061339038162;-0.02895463386945618;-0.11038844424692495;0.5724263359738284;0.09272020207001219
HELO_3790;189.21110103732804;131.94519498935858;118.49461111307023;87.40426036678969;110.72957115235528;118.78026782884592;4.188300629147931;1.9119163987488381;12.377246171694818;5.578782091076533;5.200391846494078;3.8518343709960097;rnhB;ribonuclease H2;COG0164;Ribonuclease HII;RnhB;HELO_RS15270;L;rnhB; ribonuclease H2;3.1.26.4;rnhB;ribonuclease H2;0.5167698116361938;-0.0034447053101400726;-0.10037919288927188;0.6672111834453895;0.1504413718091957
HELO_3791;347.92753461562444;262.73038214824226;214.64116960599358;176.70909306716126;187.21325970899338;208.63890941214945;9.358487846478331;14.443712308177911;4.906436292432938;0.3829328574081517;5.057585907841209;10.016421053475318;lpxB;lipid-A-disaccharide synthase;COG0763;Lipid A disaccharide synthetase;LpxB;HELO_RS15275;M;lpxB; lipid-A-disaccharide synthase;2.4.1.182;lpxB;lipid-A-disaccharide synthase;0.4038636666874549;0.04072613077847631;-0.15553823872728678;0.7350209392756133;0.3311572725881584
HELO_3792;387.9912090421453;236.80546267309512;205.54183462762384;181.92391236671423;210.74303887394737;216.1310598383982;4.069600763328446;5.713808944767962;10.318181953490859;15.113347572111255;17.95806940944748;18.156288757501468;lpxA;acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase;COG1043;Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase;LpxA;HELO_RS15280;M;lpxA; acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase;2.3.1.129;lpxA;acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase;0.7099556956971451;-0.0721320870102291;-0.03625157195689788;0.8411714383822329;0.13121574268508773
HELO_3793;848.3237856135174;755.2179288368216;401.33585846520936;275.5933542435934;335.7658200572451;466.61705183698183;63.691578794445924;84.88095459224085;30.069512194645604;23.695293679354776;53.111143946639196;76.5880226482537;fabZ;3-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ;COG0764;3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase;FabA;HELO_RS15285;I;fabZ; 3-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ;4.2.1.59;fabZ;3-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ;0.16751259976627608;-0.21692721436254025;-0.4735818193149104;0.8609871144538719;0.6934745146875958
HELO_3794;412.32838866004823;267.4050708067952;306.1282495036502;275.2657630226848;317.1506989955061;307.5266564581336;7.07158966831553;4.590233379841914;13.366977860505793;2.9132717047106684;20.933719222520857;14.349791976981944;lpxD;UDP-3-O-acylglucosamine N-acyltransferase;COG1044;UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase;LpxD;HELO_RS15290;M;lpxD; UDP-3-O-acylglucosamine N-acyltransferase;2.3.1.191;lpxD;UDP-3-O-acylglucosamine N-acyltransferase;0.6228765281127693;-0.006553925676385575;0.044315148811939764;0.4218933133651621;-0.20098321474760716
HELO_3795;449.571024943536;301.2382571338092;231.63520247278936;230.03530382940176;273.0120312676299;255.02307152390873;10.059567604843677;9.202775532722171;14.221761506674685;9.124474041344877;17.241098983225438;16.521115086951298;HELO_3795;OmpH family protein;COG2825;Periplasmic chaperone for outer membrane proteins, Skp family;HlpA;HELO_RS15295;MO;;lpxD;;HELO_3795;OmpH family protein;0.5760682530544994;-0.1382044019238533;0.09796541557898486;0.8154807159979036;0.23941246294340424
HELO_3796;293.34396430085366;249.63470577227574;424.65506336754106;463.84757114133276;362.8486458194145;393.90609102554964;13.825265192493276;6.013785040265963;12.826803476986205;10.921834791527964;21.41343662919154;20.978049734032304;bamA;outer membrane protein assembly factor bamA;COG4775;Outer membrane protein assembly factor BamA;BamA;HELO_RS15300;M;bamA; outer membrane protein assembly factor bamA;;bamA;outer membrane protein assembly factor bamA;0.23191684394035583;0.10817517199603266;-0.11817117881670391;-0.4240065754475353;-0.6559234193878911
HELO_3797;206.04241659617034;126.73144473052595;104.18749540455205;121.62343527115702;114.50189295433559;97.91349474234765;15.911401805538178;2.7979499114389568;2.299245895204686;2.166978592035329;1.7224808441666803;16.194261518526147;rseP;RseA-cleaving protease RseP;COG0750;Membrane-associated protease RseP, regulator of RpoE activity;RseP;HELO_RS15305;KO;rseP; RseA-cleaving protease RseP;3.4.24.-;rseP;RseA-cleaving protease RseP;0.69681263244797;0.08872394249279747;0.22367723005308005;1.0656870956237894;0.3688744631758194
HELO_3798;334.98804200114597;326.12172582379475;259.54536441062004;275.09739916808735;219.23901127298555;238.7832841827334;9.149594845604199;20.75868892630468;6.069065922095196;11.76020427153993;8.594312706319755;10.597188252501061;dxr;1-deoxy-D-xylulose 5-phosphate reductoisomerase;COG0743;1-deoxy-D-xylulose 5-phosphate reductoisomerase;Dxr;HELO_RS15310;I;dxr; 1-deoxy-D-xylulose 5-phosphate reductoisomerase;1.1.1.267;dxr;1-deoxy-D-xylulose 5-phosphate reductoisomerase;0.038582308263857;0.11980349792410738;-0.1226610505131136;0.48667879877889586;0.44809649051503886
HELO_3799;306.0306376032334;425.85873853562583;233.14201701081984;232.4683345766928;209.6664687224949;219.10583857366933;4.430091540273155;13.210265825806726;10.500788794634497;1.912461161559655;2.627413414906036;13.613950894932234;cdsA;phosphatidate cytidylyltransferase;COG0575;CDP-diglyceride synthetase;CdsA;HELO_RS15315;I;cdsA; phosphatidate cytidylyltransferase;2.7.7.41;cdsA;phosphatidate cytidylyltransferase;-0.475376089340493;0.08918643573031027;-0.06323671285630095;0.4801852097242012;0.9555612990646942
HELO_3800;430.5149080098579;607.8893583098287;247.53551537786686;253.10537234076105;260.95955763472216;251.08030283193912;6.665433916762117;28.41945196474798;1.2918678928545706;9.611555109181976;9.565113118527284;18.732150731665104;uppS;ditrans%2Cpolycis-undecaprenyl-diphosphate synthase ((2E%2C6E)-farnesyl-diphosphate specific);COG0020;Undecaprenyl pyrophosphate synthase;UppS;HELO_RS15320;I;uppS; ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific);2.5.1.31;uppS;ditrans%2Cpolycis-undecaprenyl-diphosphate synthase ((2E%2C6E)-farnesyl-diphosphate specific);-0.49676969626833056;-0.02043136699938941;0.055460707293799594;0.7755270099794833;1.2722967062478139
HELO_3801;686.231475726007;1274.4948156855946;677.0322154906711;611.8556299447386;677.4968533302203;660.0276684133006;39.97713116556044;77.86168591470748;26.744893331749946;21.206147681616837;30.97984723343535;15.274221724002116;frr;ribosome-recycling factor;COG0233;Ribosome recycling factor;Frr;HELO_RS15325;J;frr; ribosome-recycling factor;;frr;ribosome-recycling factor;-0.8921890154079488;0.036643162671282425;0.03763146546338447;0.05608545512437679;0.9482744705323256
HELO_3802;688.4350607957549;1018.4015286255348;807.2677009129629;776.8468221848674;901.9060712205473;833.7555883047025;13.654189398116053;54.62055271134806;74.61268962815849;97.8987690623625;77.35054218245669;78.06152131790137;pyrH;uridylate kinase;COG0528;Uridylate kinase;PyrH;HELO_RS15330;F;pyrH; uridylate kinase;2.7.4.22;pyrH;uridylate kinase;-0.5642358486734711;-0.0465206490488832;0.11322206630802256;-0.27593917856114913;0.28829667011232196
HELO_3803;2114.5515182269296;2125.0341181088766;2595.5455428250584;2232.2504159327914;2885.485467275273;2568.721859798051;42.88124457005643;81.04424662485569;279.0465525228275;213.69113185936516;308.70912393624445;229.00787042071306;tsf;translation elongation factor Ts;COG0264;Translation elongation factor EF-Ts;Tsf;HELO_RS15335;J;tsf; translation elongation factor Ts;;tsf;translation elongation factor Ts;-0.007130930247146949;0.014981315991308364;0.16770174755612643;-0.2805783953555636;-0.27344746510841667
HELO_3804;3407.081114133743;4401.47302016648;4699.908347894888;4545.015789995789;4722.229240465046;4784.605824721525;179.13814602996027;205.27274019237643;296.67815614401496;226.56089799039887;239.70156601176598;222.83254882640918;rpsB;30S ribosomal protein S2;COG0052;Ribosomal protein S2;RpsB;HELO_RS15340;J;rpsB; 30S ribosomal protein S2;;rpsB;30S ribosomal protein S2;-0.3693544898860601;-0.02576201848104631;-0.01892801357981;-0.4897418986458604;-0.12038740875980025
HELO_3805;337.409236942817;244.33020259810732;417.7389171423335;405.3569859062855;337.86426919076996;409.6296374864837;16.608534552870875;3.8369808088277457;2.6931444102215507;11.577373340708444;6.163571201701854;24.638592807615037;map;methionine aminopeptidase;COG0024;Methionine aminopeptidase;Map;HELO_RS15345;J;map; methionine aminopeptidase;3.4.11.18;map;methionine aminopeptidase;0.46404409262645885;0.028213248080680486;-0.2771302357600707;-0.27906881112260074;-0.7431129037490596
HELO_3806;174.356324886821;116.1384678441051;117.26479602592322;124.0595900698742;119.18602886771396;115.11435061186215;12.925087326742839;3.9239892710264477;3.904629595925632;2.910093457657196;7.385413249794451;3.311709541711603;glnD;bifunctional uridylyltransferase/uridylyl-removing enzyme GlnD;COG2844;UTP:GlnB (protein PII) uridylyltransferase;GlnD;HELO_RS15350;TO;glnD; bifunctional uridylyltransferase/uridylyl-removing enzyme GlnD;2.7.7.59;glnD;bifunctional uridylyltransferase/uridylyl-removing enzyme GlnD;0.5820745383433925;0.02647440303332793;0.049722912031538335;0.5947431813730484;0.012668643029655868
HELO_3807;148.31229059056486;135.33083046830745;196.47798784829573;191.55123760626486;176.97761029109145;203.9028633619129;7.18269478612138;6.557826403587289;7.974924622214623;11.719149384967524;13.46626776267055;12.919639540550167;dapC;succinyldiaminopimelate aminotransferase;COG0436;Aspartate/methionine/tyrosine aminotransferase;AspB;HELO_RS15355;E;dapC; succinyldiaminopimelate aminotransferase;2.6.1.17;dapC;succinyldiaminopimelate aminotransferase;0.13122106871672212;-0.053248294765097626;-0.20324438450474158;-0.45660721974424323;-0.5878282884609654
HELO_3808;73.72957976163458;65.86300148125753;84.6597395465817;73.0723292322184;82.8222829645412;94.80278219352901;8.727042147565935;9.233168495486114;11.204501400250702;6.602414883652532;5.7945276685151885;17.284879552432656;HELO_3808;YffB family protein;COG1393;Arsenate reductase or related protein, glutaredoxin family;ArsC;HELO_RS15360;P;;dapC;;HELO_3808;YffB family protein;0.16047129037977115;-0.16145026301211818;-0.19273373873356014;-0.35838814425629106;-0.5188594346360622
HELO_3809;316.26952531859985;345.4696389306188;611.2939011777789;510.6943705243006;556.4490711650725;630.1217024264196;36.64527753897126;12.962064786295306;27.474036075846055;28.504420724816114;9.754265412963004;15.109547485893057;dapD;2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase;COG2171;Tetrahydrodipicolinate N-succinyltransferase;DapD;HELO_RS15365;E;dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase;2.3.1.117;dapD;2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase;-0.12701998204448195;-0.04369392126253224;-0.17907822861003808;-0.9922092815383312;-0.8651892994938493
HELO_3810;164.24664444857635;221.39198702863726;353.1629956167933;294.9924529305081;330.70456602474854;376.16050315516105;20.595045978711944;14.3064924792444;17.604981362579633;27.003295925966448;3.274440790210632;13.457883633760328;dapE;succinyl-diaminopimelate desuccinylase;COG0624;Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase;ArgE;HELO_RS15370;E;dapE; succinyl-diaminopimelate desuccinylase;3.5.1.18;dapE;succinyl-diaminopimelate desuccinylase;-0.4284838312738497;-0.0907651212679017;-0.18527973117073238;-1.1905576264134439;-0.7620737951395942
HELO_3811;163.59699513648616;216.53129430716322;188.46608516892323;132.54635587407617;133.2799936711218;157.78000696302405;16.413199942259993;19.46459545322003;9.03597001898769;4.512718983190377;14.514590357706894;14.325540590134969;HELO_3811;uncharacterized protein;;;;;;;;;HELO_3811;uncharacterized protein;-0.40228496536487235;0.2549103613573136;-0.24178489052639307;0.05190873365036186;0.4541936990152342
HELO_3812;348.7187501622354;364.29084929099116;498.8344859877754;1598.3997673115462;570.525624183304;501.05128922712896;12.593541297565883;21.284890623474375;62.25265455511826;51.57344651070444;65.70317161022065;35.295805923979316;cspA4;cold shock protein CspA;COG1278;Cold shock protein, CspA family;CspC;HELO_RS15380;K;cspA4; cold shock protein CspA;;cspA4;cold shock protein CspA;-0.06285046578904385;-0.006384313138898534;0.18698342622314534;-0.521639608306014;-0.4587891425169701
HELO_3813;57.17663369905069;36.97414695293961;79.43556230465255;88.17444888899593;74.07897970490686;67.16956894541833;1.8799883987228025;2.0889783191842572;2.0752316309930254;3.3202232486341643;14.456194962826817;1.3363465738027955;HELO_3813;SlyX family protein;COG2900;Uncharacterized coiled-coil protein SlyX (sensitive to lysis X);SlyX;HELO_RS15385;S;;cspA4;;HELO_3813;SlyX family protein;0.615422262987007;0.23870562865893508;0.13928118409714418;-0.22868804098627038;-0.8441103039732774
HELO_3814;257.6238688698549;157.21811278819527;186.7448959690247;232.53875241201;208.4797582516386;190.9735285411233;11.375293088028135;5.948437352320127;17.531177036655844;10.084436302475241;8.244677907854618;12.960524767204467;trxB;thioredoxin reductase;COG0492;Thioredoxin reductase;TrxB;HELO_RS15390;O;trxB; thioredoxin reductase;;trxB;thioredoxin reductase;0.7089406614580049;-0.03213370254166037;0.12590345525020563;0.4299480405361713;-0.27899262092183363
HELO_3815;48.64692714486034;30.701924099017756;50.811951010954296;118.5484902774467;40.63062517356357;46.59602502651301;2.590520555684991;5.995443456076959;10.114397366183718;29.783745721768828;4.473099398398896;6.5220425802840465;HELO_3815;CPXCG domain protein;;;;;;;;;HELO_3815;CPXCG domain protein;0.647134020955348;0.12244381803519921;-0.1931958683304602;0.06086333396414023;-0.5862706869912078
HELO_3816;247.30834089993186;326.55532666366247;419.07176687416285;1194.129060151186;703.6019727741951;409.5417838550266;33.34057154683467;3.200662709015084;46.474255553633455;88.24048819066992;61.96634492992257;85.3237331683874;acnA;aconitate hydratase;COG1048;Aconitase A;AcnA;HELO_RS15400;C;acnA; aconitate hydratase;4.2.1.3;acnA;aconitate hydratase;-0.3996058859903009;0.03310676204284846;0.7792794510021093;-0.7253963394051972;-0.3257904534148963
HELO_3817;273.3997722865352;343.2922958242609;359.8388738024721;321.3280342531503;466.11278307829417;348.22377371200065;9.679248762859908;10.749290897544958;23.29429546738372;10.88025535219326;20.51778612041105;20.39730570843674;maeA;malic enzyme (NAD);COG0281;Malic enzyme;SfcA;HELO_RS15405;C;maeA; malic enzyme (NAD);1.1.1.38;maeA;malic enzyme (NAD);-0.32735461402807786;0.047202995994327424;0.41961915165702024;-0.34787249075366056;-0.020517876725582695
HELO_3818;177.07402468764147;210.74823708981714;194.10999102548817;167.4938987845047;176.00152651693088;195.49047970540911;3.510469150532473;2.7106940347956057;4.250939102752813;6.706544680789223;3.743299277726647;7.226330037599153;trpS;tryptophan--tRNA ligase;COG0180;Tryptophanyl-tRNA synthetase;TrpS;HELO_RS15410;J;trpS; tryptophan--tRNA ligase;6.1.1.2;trpS;tryptophan--tRNA ligase;-0.2498728697873025;-0.010171757041494978;-0.150697610554813;-0.14198232451230108;0.10789054527500141
HELO_3819;150.99292340377045;546.1490447216696;202.15215340568932;354.1181411871617;102.61358546266327;187.63476449694477;11.104998461117365;38.67460689100761;23.147101938623592;42.654983984906586;10.936700380970294;31.432060644443744;ald;alanine dehydrogenase;COG0686;Alanine dehydrogenase (includes sporulation protein SpoVN);Ald;HELO_RS15415;E;ald; alanine dehydrogenase;1.4.1.1;ald;alanine dehydrogenase;-1.8479297249728823;0.10696507476231787;-0.8643824056866354;-0.3115914272089837;1.5363382977638986
HELO_3820;93.75662629215265;99.9290480936657;48.57678912457053;37.7752131564078;46.91728624602981;42.5426124274467;6.362628047293445;2.3496798041090394;2.5481822000617353;5.097858770878601;4.190666028833236;5.00596844748848;HELO_3820;thioesterase domain protein;COG0824;Acyl-CoA thioesterase FadM;FadM;HELO_RS15420;I;;ald;3.1.2.-;HELO_3820;thioesterase domain protein;-0.09104271304181921;0.1872368697554787;0.13811823711600102;1.1217988663448013;1.2128415793866205
HELO_3821;128.69553428904138;192.65357656296135;74.87012720256176;64.73217166032923;73.55020777058388;78.39460906366203;1.697636079383856;22.74269543948845;10.407331550927825;5.65423901879137;9.161892521411689;6.530695718105992;HELO_3821;DUF2007 domain protein;;;;;;;;;HELO_3821;DUF2007 domain protein;-0.5783493413738192;-0.06550909440818042;-0.09082867764138136;0.7080158491443109;1.2863651905181301
HELO_3822;128.6420404976944;181.33027682275142;120.72188347230895;105.1365674296821;116.88609316864851;109.18070189906994;3.857201417567724;6.395900419639173;7.217416094923394;8.323007309397536;13.164377126423396;5.089132341076206;HELO_3822;probable S-adenosylmethionine-dependent methyltransferase;COG1092;23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI;RlmK;HELO_RS15430;J;;;2.1.1.191;HELO_3822;probable S-adenosylmethionine-dependent methyltransferase;-0.49202051453660545;0.14371700414240784;0.09752197731895063;0.23466207456923804;0.7266825891058435
HELO_3823;265.1063266534217;379.202338425454;197.12452299543193;178.64507225176325;187.67510286944955;201.16448488973666;8.910239388874762;21.33986414907934;6.928863352379576;12.667018282622108;4.843273246067231;17.002519411807377;mutM;formamidopyrimidine-DNA glycosylase;COG0266;Formamidopyrimidine-DNA glycosylase;Nei;HELO_RS15435;L;mutM; formamidopyrimidine-DNA glycosylase;3.2.2.23,4.2.99.18;mutM;formamidopyrimidine-DNA glycosylase;-0.5147645945656638;-0.02912211319278235;-0.09962551422227328;0.39647323569300674;0.9112378302586706
HELO_3824;14790.070696425862;17787.60067347188;5100.201452928398;3351.7160054490614;4024.7693602040295;5163.583669003567;1098.9089345142456;1283.8856046134379;1376.4574093989208;316.97836171457084;1344.7964250354291;1461.5253119093593;rpmG;50S ribosomal protein L33;COG0267;Ribosomal protein L33;RpmG;HELO_RS15440;J;rpmG; 50S ribosomal protein L33;;rpmG;50S ribosomal protein L33;-0.2662265365131393;-0.017814978525116487;-0.35938753286102276;1.5180025307064238;1.784229067219563
HELO_3825;5100.133876132807;5918.294303823604;5224.947554347046;5153.205772875227;4783.995189714976;6149.3655644909595;515.6086184397179;1186.9693957613053;472.4105282392774;347.63966190473315;680.4894722814279;691.074107383682;rpmB;50S ribosomal protein L28;COG0227;Ribosomal protein L28;RpmB;HELO_RS15445;J;rpmB; 50S ribosomal protein L28;;rpmB;50S ribosomal protein L28;-0.21460722463386794;-0.23497951730500866;-0.3621546892963323;-0.26985419980930914;-0.05524697517544119
HELO_3826;18.15414497138545;8.105810445700191;23.314143136367004;38.57494835429268;32.813653044166294;20.186312407317327;1.3859275802775768;0.9638460828462986;4.235857497984028;1.3283588483333055;3.865077006362015;3.0971283900758926;HELO_3826;UPF0758 family protein;COG2003;DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif;RadC;HELO_RS15450;L;;rpmB;;HELO_3826;UPF0758 family protein;1.0727972938132364;0.19866324927001244;0.6744733849617539;-0.14547587442977772;-1.2182731682430141
HELO_3827;206.9620608036089;177.5566680545509;268.59222654986974;277.2291603209721;272.0998995985797;259.8832455158027;9.082602314939567;1.8738788251186451;19.895106124096475;15.911156659917005;32.52415607815562;26.20119813147945;HELO_3827;phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase;COG0452;Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC;CoaBC;HELO_RS15455;H;;;4.1.1.36,6.3.2.5;HELO_3827;phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase;0.21993834560292225;0.04737460415546657;0.06602448957024265;-0.32708393733210617;-0.5470222829350284
HELO_3828;227.30988222281076;222.89304720218743;299.81695953790745;267.66864207875324;287.0974543085061;295.55212395845473;12.004450437601573;15.953308680438148;30.034890170501846;13.07849749764005;15.214287369135084;8.099751937470145;dut;deoxyuridine 5'-triphosphate nucleotidohydrolase;COG0756;dUTP pyrophosphatase (dUTPase);Dut;HELO_RS15460;VF;dut; deoxyuridine 5'-triphosphate nucleotidohydrolase;3.6.1.23;dut;deoxyuridine 5'-triphosphate nucleotidohydrolase;0.028183579606616327;0.02060020128924478;-0.04172879207252578;-0.37729239776889223;-0.40547597737550856
HELO_3829;357.6904553244224;326.4472299934811;709.5596552894918;675.9175491032353;709.5098659530449;686.7515508747073;34.18490807643637;17.4735094756479;23.073883166065183;17.558304057569394;82.76633756873579;64.31488588983134;algC;phosphoglucomutase / phosphomannomutase;COG1109;Phosphomannomutase;ManB;HELO_RS15465;G;algC; phosphoglucomutase / phosphomannomutase;5.4.2.8,5.4.2.2;algC;phosphoglucomutase / phosphomannomutase;0.13147692923302756;0.047068288717984075;0.04696719467897026;-0.9391481318092705;-1.070625061042298
HELO_3830;214.82272961092121;184.85880765120228;323.8327709237714;306.2440384811717;380.83499349941707;364.9695748777927;12.501338200503763;1.6407340669883113;20.702301785763286;25.990142021784266;29.18391759574803;24.99454583841205;argB;acetylglutamate kinase;COG0548;N-acetylglutamate kinase;ArgB;HELO_RS15470;E;argB; acetylglutamate kinase;2.7.2.8;argB;acetylglutamate kinase;0.2156397542577686;-0.17202652718185085;0.061225611372204725;-0.7618769022291563;-0.9775166564869249
HELO_3831;341.66197448672716;349.89786692180945;524.7253293643528;423.6677493870902;425.4652552309189;528.5702415250885;38.14997491423815;24.873060895845107;20.088870722826712;19.064319184791408;54.940110211985576;20.828609769121893;slmA;nucleoid occlusion factor SlmA;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS15475;K;slmA; nucleoid occlusion factor SlmA;;slmA;nucleoid occlusion factor SlmA;-0.034265074197747936;-0.010512808743316171;-0.31239384636436895;-0.6280359506006832;-0.5937708764029352
HELO_3832;1105.7236986299092;412.2092812678873;424.60768756559736;468.48769254045004;434.3249415038754;378.80168396553654;35.245818891694704;8.582777230327258;19.76253219317547;28.102573792493196;64.51600779121442;48.53549048495459;rpoH;RNA polymerase sigma factor RpoH;COG0568;DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32);RpoD;HELO_RS15480;K;rpoH; RNA polymerase sigma factor RpoH;;rpoH;RNA polymerase sigma factor RpoH;1.4213505234282842;0.1642779077182528;0.1968463781264429;1.5429768808507713;0.12162635742248717
HELO_3833;212.19433421132362;170.00559960431966;170.9017321303365;176.84887488976506;175.99481233705907;170.86781093952928;8.548733940123276;3.8115548710985365;7.67798320768114;7.923203126366295;3.5201955454310845;4.617666611724034;ftsX;cell division protein FtsX;COG2177;Cell division protein FtsX;FtsX;HELO_RS15485;D;ftsX; cell division protein FtsX;;ftsX;cell division protein FtsX;0.3181255308231048;0.0002847136106387538;0.04240770770396196;0.31086972969517923;-0.007255801127925565
HELO_3834;167.04655019752872;155.69229854824832;98.31251163502382;99.39868757492563;107.10427356878476;103.92084136848685;7.320422261267724;6.138155950566812;4.843913891631334;4.320236753271058;2.040067633798382;8.71349059455456;ftsE;cell division ATP-binding protein FtsE;COG2884;Cell division ATPase FtsE;FtsE;HELO_RS15490;D;ftsE; cell division ATP-binding protein FtsE;;ftsE;cell division ATP-binding protein FtsE;0.1009266532203732;-0.07925389325332244;0.04312227484833464;0.6795596442323664;0.5786329910119932
HELO_3835;237.25940628883652;242.45920188723142;261.3950246972607;245.02002278556574;240.9022976762739;257.5826333586708;6.883610933936914;8.395051616487107;7.065131557183636;9.068101752289662;8.698816539474947;8.72999445538358;ftsY;signal recognition particle receptor FtsY;COG0552;Signal recognition particle GTPase FtsY;FtsY;HELO_RS15495;U;ftsY; signal recognition particle receptor FtsY;;ftsY;signal recognition particle receptor FtsY;-0.03114685865709177;0.02111497939578655;-0.09620091308347867;-0.11809221401621794;-0.08694535535912618
HELO_3836;70.9276175355493;42.425287454175454;59.252762448659134;62.27129627891329;59.29763893609047;58.6291029397186;6.027206091772082;4.117751809873978;3.4405129337584266;8.592557822957115;1.5213950868233992;8.78671734743171;rsmD;16S rRNA (guanine(966)-N(2))-methyltransferase RsmD;COG0742;16S rRNA G966 N2-methylase RsmD;RsmD;HELO_RS15500;J;rsmD; 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD;2.1.1.171;rsmD;16S rRNA (guanine(966)-N(2))-methyltransferase RsmD;0.7280104194853045;0.01501075404266139;0.01608487885878329;0.27052918536875215;-0.4574812341165524
HELO_3837;952.2536076277405;368.940727052322;1511.511087990768;1174.2124002544122;1036.2249490692877;1202.8653963318636;97.88294911304897;93.94742886723942;230.044535618344;272.91025451347554;103.9317022136235;104.28453808263768;zapB;cell division protein ZapB;COG3074;Cell division protein ZapB, interacts with FtsZ;ZapB;HELO_RS15505;D;zapB; cell division protein ZapB;;zapB;cell division protein ZapB;1.3655659493156147;0.3292716245982401;-0.2149452801722962;-0.336742102994144;-1.7023080523097587
HELO_3838;168.5245228322167;189.2756600613701;83.82170592330385;87.48980699076326;97.2914749969362;77.05320576697405;2.210801388336604;13.997699901314009;8.743273450108163;7.799044220995079;2.3901407803489665;4.521973586353551;HELO_3838;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS15510;J;;zapB;2.3.1.266;HELO_3838;GNAT family acetyltransferase;-0.1665970410620874;0.11997561136741997;0.3326084072015796;1.118964191472048;1.2855612325341355
HELO_3839;204.5774623281728;208.83505003265154;137.61225989246518;148.86407168801688;168.0690050480741;137.8178721908675;3.063258284092336;18.541925014390007;8.403982706035181;8.971285209939534;5.978957260503165;3.381408637898043;HELO_3839;uncharacterized protein;;;;;;;;;HELO_3839;uncharacterized protein;-0.029573571188693748;-0.0021384547910132667;0.2844188781878936;0.5664887885184751;0.5960623597071688
HELO_3840;158.13736826118472;181.284620776899;103.68836793514883;93.47468967103555;109.0744489089606;113.90885205886038;2.6023988502572446;21.733816175613672;17.638128112008225;5.745856657118558;17.48201644399579;6.597720300288221;bolA;morphogene BolA;COG0271;DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation;BolA;HELO_RS15520;KT;bolA; morphogene BolA;;bolA;morphogene BolA;-0.19592020166858237;-0.13438878957929834;-0.062010319576844886;0.46978270472032957;0.6657029063889119
HELO_3841;114.02222425650099;113.79239628935386;90.52454126757243;95.37463577386497;84.93017830658071;88.80335116690655;2.892096879827376;6.4045277181109865;1.9162192273252665;3.2263651481294016;4.326224233582805;9.583021348580106;HELO_3841;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS15525;G;;bolA;;HELO_3841;major facilitator superfamily transport protein;0.0028855586142437772;0.02738935495607997;-0.06360439401766182;0.3570714536667232;0.35418589505247944
HELO_3842;422.2184973359783;597.764791241376;455.48082674551847;483.90125531933535;461.00272791093647;436.44809114704776;11.751078632605768;25.999985410884655;43.573598977594166;22.246362090049942;6.978791127220379;5.306340885812247;HELO_3842;uncharacterized protein;;;;;;;;;HELO_3842;uncharacterized protein;-0.5005867063105178;0.061442432196743724;0.07878953736451955;-0.047709148979224736;0.4528775573312931
HELO_3843;317.0170214892867;585.666058839654;634.4091733926404;619.4096358106738;618.8069910938398;648.4318533327372;13.864374867163946;21.92239229796748;15.274705990173679;30.180663036171982;31.981799490066663;15.846886180127502;lysS;lysine--tRNA ligase;COG1190;Lysyl-tRNA synthetase, class II;LysU;HELO_RS15535;J;lysS; lysine--tRNA ligase;6.1.1.6;lysS;lysine--tRNA ligase;-0.8834355421550715;-0.03149222929571138;-0.06735911981386344;-1.0300741615223306;-0.14663861936725908
HELO_3844;320.46190548752907;465.30117191932203;655.2422161766759;665.0290917927409;523.5398333502095;616.8065616771942;12.583487838684942;16.425393056543513;10.064089130084929;10.039890949615339;40.22118149952694;27.839766821229528;prfB;peptide chain release factor 2;COG1186;Protein chain release factor PrfB;PrfB;HELO_RS15540;J;prfB; peptide chain release factor 2;;prfB;peptide chain release factor 2;-0.536614272907741;0.08707321186342654;-0.23610285914189788;-0.9425074112123344;-0.4058931383045934
HELO_3845;6.531094266173799;14.943002228040598;33.99701585409064;29.947223190995448;18.737026784090073;41.64557612226886;0.29831646655203947;2.333809109118489;1.142320001686912;1.893865175594432;2.5080141972461703;3.7019272585734115;HELO_3845;ABC-type transport system periplasmic substrate-binding protein;COG4166;ABC-type oligopeptide transport system, periplasmic component;OppA;HELO_RS15545;E;;prfB;;HELO_3845;ABC-type transport system periplasmic substrate-binding protein;-1.0819919204504287;-0.28516417927785476;-1.1114914136457568;-2.501464681539145;-1.4194727610887163
HELO_3846;2.354934826076654;6.363561801196938;16.924387196541165;13.342164828374173;9.465786302405006;19.639472917932384;0.5677879802900772;0.6461044982703252;1.1751184057532937;0.7303491685804308;1.5965748034077072;0.6565790766979536;HELO_3846;ABC-type transport system periplasmic substrate-binding protein;COG4166;ABC-type oligopeptide transport system, periplasmic component;OppA;HELO_RS15550;E;;;;HELO_3846;ABC-type transport system periplasmic substrate-binding protein;-1.1341190352935102;-0.20348233175089447;-0.9797254218699365;-2.6210494826963044;-1.4869304474027945
HELO_3847;3.068198745092983;9.009905046952959;13.552495939299519;8.9454179653299;6.35077225290365;15.443129603644808;0.6154411645087019;0.619088229657974;1.2747770190568732;1.8057743345111863;0.6420974770842192;0.5043498111015012;HELO_3847;ABC-type transport system permease protein;COG0601;ABC-type dipeptide/oligopeptide/nickel transport system, permease component;DppB;HELO_RS15555;EP;;;;HELO_3847;ABC-type transport system permease protein;-1.298966222465316;-0.17621829677169032;-1.1615171829999964;-2.0150228452909076;-0.7160566228255916
HELO_3848;2.5158781232993612;7.844024127074694;10.409081174429739;7.604677813760024;6.242187982890845;11.379616363683274;0.170349602150801;0.9053439070461583;1.4106072257148392;1.3541498513351287;0.8051009647828669;2.295392159561144;HELO_3848;ABC-type transport system permease protein;COG1173;ABC-type dipeptide/oligopeptide/nickel transport system, permease component;DppC;HELO_RS15560;EP;;;;HELO_3848;ABC-type transport system permease protein;-1.3308179001028224;-0.11778399759277303;-0.7734690771237926;-1.8160096411217366;-0.48519174101891416
HELO_3849;5.649998844395252;14.607561035062503;22.474913796481612;16.787154995359824;13.773053161670132;26.106573171891455;0.5954033180609535;0.10112999737048967;2.465541495376062;1.782955521776234;1.2121792324607883;1.1886222506161495;HELO_3849;ABC-type transport system ATP-binding protein;COG4172;ABC-type microcin C transport system, duplicated ATPase component YejF;YejF;HELO_RS15565;Q;;;;HELO_3849;ABC-type transport system ATP-binding protein;-1.2308191125991823;-0.20752287830191118;-0.8756747182465014;-2.0272167433692108;-0.7963976307700285
HELO_3850;3.9210639266410596;31.849643294624112;23.338179661299264;33.87767708950885;8.437344902065748;29.04171499828378;0.12118492951376476;3.845661822965177;1.2788696192793905;3.9735320608688944;0.8071686276479567;2.747511382090957;HELO_3850;outer membrane porin;COG3203;Outer membrane porin OmpC/OmpF/PhoE;OmpC;HELO_RS15570;M;;;;HELO_3850;outer membrane porin;-2.7388355418947214;-0.30374590685393077;-1.67051423998846;-2.6099250117628645;0.12891053013185694
HELO_3851;165.9171175073566;50.04974300245133;337.64998464131537;331.45718178019007;391.2994618043111;305.9650581037727;6.296994288081298;2.896614284815481;24.68383961725154;15.091969906567577;40.17956239087035;20.69480288267787;HELO_3851;FadL family protein;COG2067;Long-chain fatty acid transport protein;FadL;HELO_RS15575;I;;;;HELO_3851;FadL family protein;1.709156308684518;0.14172048766166867;0.3538809135170702;-0.8789425306454923;-2.5880988393300104
HELO_3852;9.829210817540305;9.692453483409187;31.980492144407677;39.401068120250045;101.58225664311533;33.56045024720222;0.23741206865333825;1.086444742706324;2.769476406164139;1.9581561423646052;47.131474012600485;3.4612078296309794;HELO_3852;MerR family transcription regulator;COG0789;DNA-binding transcriptional regulator, MerR family;SoxR;HELO_RS15580;K;;;;HELO_3852;MerR family transcription regulator;0.01833517897177872;-0.06750908554285218;1.5695872958231645;-1.6741939029098747;-1.6925290818816534
HELO_3853;19.69005713692476;14.974987526000616;60.529603930015234;77.19701065673149;107.57582306814199;66.8449787270377;0.7375976465627823;0.673221228190136;6.378659811881239;1.8782600496002524;10.886877483131078;9.810717739624014;copA;P-type transport ATPase (probable substrate copper-I);COG2608;Copper chaperone CopZ;CopZ;HELO_RS15585;P;copA; P-type transport ATPase (probable substrate copper-I);7.2.2.8;copA;P-type transport ATPase (probable substrate copper-I);0.3731228246480818;-0.14096133848110348;0.6783889398615734;-1.7133044150312662;-2.086427239679348
HELO_3854;44.24925383550828;31.528474651366906;91.19146489025358;137.97806968351563;142.76561593322697;95.92034657802053;2.8840011519916278;1.6555685830068472;5.072548681650802;5.84796733360182;5.401896926996304;9.511459442489286;HELO_3854;glyoxalase domain protein;COG2514;Catechol-2,3-dioxygenase;CatE;HELO_RS15590;Q;;copA;;HELO_3854;glyoxalase domain protein;0.476190830142289;-0.07216637198425335;0.5688472023753874;-1.0989055615261174;-1.5750963916684064
HELO_3855;207.54944014971707;163.92987200788255;221.77072190688992;175.7278710110586;219.7171832440467;224.89199153526656;8.133710956397474;4.310089965889307;12.04259231386779;6.550286396993757;16.9861058929193;21.108554993882045;HELO_3855;DHH/RecJ family phosphoesterase;COG0608;ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation;RecJ;HELO_RS15595;L;;;3.1.-.-;HELO_3855;DHH/RecJ family phosphoesterase;0.33853671674689867;-0.02007348828674349;-0.033434173819760105;-0.1152436849848284;-0.45378040173172707
HELO_3856;504.9556684703269;471.86856368891443;646.9884325860521;454.18206856059396;583.465211306027;673.0087187388855;27.200977679368524;15.838711108660286;33.31322707876162;24.913631655331727;25.41361404595629;36.40637144715377;thrC;threonine synthase;COG0498;Threonine synthase;ThrC;HELO_RS15600;E;thrC; threonine synthase;4.2.3.1;thrC;threonine synthase;0.0975717478002629;-0.05679919431499769;-0.20565009888764685;-0.41375627133145976;-0.5113280191317227
HELO_3857;677.6604356206923;667.0341886546249;1038.9310632401296;790.2320276739209;910.7636807237581;1086.2770383152495;35.00788687957136;15.279187405008049;49.767800902047796;53.8471014748271;30.47296878711083;40.55449779016767;hom;homoserine dehydrogenase;COG0460;Homoserine dehydrogenase;ThrA;HELO_RS15605;E;hom; homoserine dehydrogenase;1.1.1.3;hom;homoserine dehydrogenase;0.022767970857625386;-0.06423169041194399;-0.2539877390525316;-0.6799577712609679;-0.7027257421185933
HELO_3858;203.04985357025032;100.05417370288905;152.08240371463853;167.68717662263057;123.29131700406462;143.43549487980582;3.446092190244974;2.779273376485649;3.4190662720926377;15.45942839889798;6.581252277950991;5.63328507329849;HELO_3858;DsbC family protein;COG1651;Protein thiol-disulfide isomerase DsbC;DsbG;HELO_RS15610;O;;hom;5.3.4.1;HELO_3858;DsbC family protein;1.0137927666768167;0.08388313295971273;-0.2166998134910063;0.4984963486195575;-0.5152964180572592
HELO_3859;155.16629635210765;118.87576611628576;108.382525328523;158.41369916522993;92.7313069200746;115.81317045190781;11.289373016527874;3.16021129002107;1.5680039905487209;8.078904490652617;4.857904403627067;15.939471844231106;xerD;tyrosine recombinase XerD;COG4974;Site-specific recombinase XerD;XerD;HELO_RS15615;L;xerD; tyrosine recombinase XerD;;xerD;tyrosine recombinase XerD;0.3815430907087318;-0.09482066909340947;-0.3176000405297472;0.41888018175251407;0.037337091043782245
HELO_3860;3336.1106331086835;2523.356376538765;2504.1329792654556;2401.5151604606544;1910.372073528362;2141.7175156492726;234.0697149466457;17.298340459155963;75.72683994111472;64.289131004516;178.3282190614098;298.5603742533731;rplS;50S ribosomal protein L19;COG0335;Ribosomal protein L19;RplS;HELO_RS15620;J;rplS; 50S ribosomal protein L19;;rplS;50S ribosomal protein L19;0.40268391859283703;0.2254455222287053;-0.16483302031877578;0.6391578506678961;0.23647393207505907
HELO_3861;1986.004841840322;2197.4525946492845;1434.3886148902313;1590.9285216148662;1059.4157585748746;1338.1976447514342;88.2282455994204;196.12422187509472;45.736582908175805;75.16225324197445;85.06669149832192;22.45485480148192;trmD;tRNA (guanine-N(1)-)-methyltransferase TrmD;COG0336;tRNA G37 N-methylase TrmD;TrmD;HELO_RS15625;J;trmD; tRNA (guanine-N(1)-)-methyltransferase TrmD;2.1.1.228;trmD;tRNA (guanine-N(1)-)-methyltransferase TrmD;-0.1458930358921755;0.10007248707191252;-0.33673888072422464;0.569226492350003;0.7151195282421785
HELO_3862;3027.995369795895;2567.194126975661;1359.706770073339;1390.2186503073044;1197.848353911509;1391.1148375306627;144.66597384678212;192.0204441153117;70.17833973681518;66.06473949069229;74.29986089619763;169.18425342406883;rimM;ribosome maturation factor RimM;COG0806;Ribosomal 30S subunit maturation factor RimM, required for 16S rRNA processing;RimM;HELO_RS15630;J;rimM; ribosome maturation factor RimM;;rimM;ribosome maturation factor RimM;0.23808511447550984;-0.03292202397842381;-0.21562904678671657;1.1215611467333222;0.8834760322578123
HELO_3863;1984.904666674776;1805.5263606737183;1833.29298603529;1886.4406477690954;1351.0393823666261;1681.6224941153312;175.2289203600634;279.854296342634;313.9251743455869;80.9198318399786;131.20726425418664;184.99445009397047;rpsP;30S ribosomal protein S16;COG0228;Ribosomal protein S16;RpsP;HELO_RS15635;J;rpsP; 30S ribosomal protein S16;;rpsP;30S ribosomal protein S16;0.136578061370626;0.12451255845605758;-0.3155743609421382;0.2390848318038028;0.1025067704331768
HELO_3864;274.53641577631265;373.4361697310438;409.2172779381187;470.42196938276464;378.03258193838855;366.2348299660686;8.144633860831126;2.297763792708493;22.793659020646896;25.703967280400377;22.506921482358027;3.617597132522125;ffh;SRP54-type signal recognition particle protein;COG0541;Signal recognition particle GTPase;Ffh;HELO_RS15640;U;ffh; SRP54-type signal recognition particle protein;3.6.5.4;ffh;SRP54-type signal recognition particle protein;-0.4424768002994295;0.15968536196125172;0.045618972928863855;-0.4144598933961472;0.02801690690328229
HELO_3865;139.59422389347804;121.173266127948;103.3016249738531;119.27401032389268;112.2890892165625;99.26989526436905;6.350869349709324;9.175810456033139;2.2643601867177496;8.524934267766403;3.243557278399596;17.339949285037047;HELO_3865;YpjD family protein;COG4137;ABC-type uncharacterized transport system, permease component;YpjD;HELO_RS15645;R;;ffh;;HELO_3865;YpjD family protein;0.2026086944969645;0.056873114107061085;0.17612040253399108;0.48764880414242473;0.2850401096454602
HELO_3866;129.8929586332025;90.40305544410563;95.50048912402264;110.17806434153341;95.09823842098535;89.73096992034026;1.5609401036484951;2.0048942429046357;4.341922447136242;3.3390172734983374;1.4680925057517091;6.809590501044879;HELO_3866;UPF0053 family protein;COG4536;Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains;CorB;HELO_RS15650;P;;;;HELO_3866;UPF0053 family protein;0.5180731918390551;0.08894117352856057;0.08291490382615585;0.5287205033583406;0.010647311519285552
HELO_3867;175.7232265874768;100.32736350977397;96.4427773311852;111.07600431029475;79.77931201248991;92.08953682565861;2.036951669478861;3.7178008184044535;5.490881110997737;13.917625845835362;4.4311740388703065;5.297333819201345;HELO_3867;acyltransferase domain protein;COG0204;1-acyl-sn-glycerol-3-phosphate acyltransferase;PlsC;HELO_RS15655;I;;;2.3.1.51;HELO_3867;acyltransferase domain protein;0.8024678372296661;0.0659362344156218;-0.2046331605262468;0.924800740091487;0.12233290286182097
HELO_3868;208.0349293523822;123.44765357279967;157.4308028561263;153.2419320985749;127.96680897869875;168.0641843309028;8.774005357948704;9.029745993169772;7.528533682161791;3.876273841157031;10.997031578842597;7.5174565414195476;HELO_3868;TetR_Cterm domain protein;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS15660;K;;;;HELO_3868;TetR_Cterm domain protein;0.7482050051921263;-0.09371820391564079;-0.39057124206453686;0.3061729720310673;-0.442032033161059
HELO_3869;40.66244649689961;27.83442343672051;34.951924868282745;32.32797683585273;28.082673219536503;32.546151520651854;1.7474844364129178;2.1408122692376783;1.203734117702466;1.615761698577219;2.297871269894853;1.6584606398797828;HELO_3869;DUF159 family protein;COG2135;ssDNA abasic site-binding protein YedK/HMCES, SRAP family;SRAP;HELO_RS15665;L;;;;HELO_3869;DUF159 family protein;0.5309553845749644;0.09992174755959127;-0.20598738223975221;0.31260029246666665;-0.21835509210829773
HELO_3870;89.5106649372055;17.207087354308797;80.63563899020964;65.38917664233607;60.319731479172816;70.36066078978139;11.05594007718006;1.1516775103092425;3.2653669080703294;0.8889023151989587;9.751755394731187;3.903066243951451;HELO_3870;peptidase M16 family protein;COG1025;Secreted/periplasmic Zn-dependent peptidases, insulinase-like;Ptr;HELO_RS15670;O;;;3.4.24.56;HELO_3870;peptidase M16 family protein;2.313587647756112;0.19407014058469674;-0.21877759506684225;0.34295882153823154;-1.9706288262178804
HELO_3871;195.5841205993413;126.8355979519888;141.1708607745778;152.4820018171662;144.5486009201104;154.886495125294;6.983225091992137;1.7866060510367794;11.282989965701107;1.054392553405629;7.296792347340875;8.593639816715482;sbcB;exodeoxyribonuclease 1;COG2925;Exonuclease I (degrades ssDNA);SbcB;HELO_RS15675;L;sbcB; exodeoxyribonuclease 1;3.1.11.1;sbcB;exodeoxyribonuclease 1;0.6208571556562852;-0.13287014718117174;-0.09899497713913519;0.3346508415367113;-0.28620631411957387
HELO_3872;2563.6165643984946;859.5417783270087;404.30531830722845;317.7939819030771;386.4078886578004;442.0300997704612;107.54773036111322;80.81350932602824;135.41132476781448;20.39112908004295;127.73421268123596;121.65291871031965;minE;cell division topological specificity factor MinE;COG0851;Septum formation topological specificity factor MinE;MinE;HELO_RS15680;D;minE; cell division topological specificity factor MinE;;minE;cell division topological specificity factor MinE;1.5754260044581319;-0.12839561364126872;-0.19355138844714048;2.5332665198252986;0.9578405153671667
HELO_3873;814.744917607588;207.95714083450022;532.3671261839883;513.4239776418148;481.9239279338787;512.7992325802448;28.599954461784833;13.54001349665467;26.73797706759878;2.3243797823576697;27.18169020304757;20.6012787607382;minD;septum site-determining protein MinD;COG2894;Septum site-determining ATPase MinD;MinD;HELO_RS15685;D;minD; septum site-determining protein MinD;;minD;septum site-determining protein MinD;1.9649110321200096;0.05392417243670167;-0.08940878741265479;0.6669133584165472;-1.2979976737034624
HELO_3874;949.1538787815963;293.79985226474514;702.5274182414854;791.1804663416477;723.837612537237;717.2522386978438;27.491762507430437;11.117232150568325;41.432132647478866;19.39258352209543;33.94079652570612;26.447806684829988;minC;septum site-determining protein MinC;COG0850;Septum site-determining protein MinC;MinC;HELO_RS15690;D;minC; septum site-determining protein MinC;;minC;septum site-determining protein MinC;1.6884253774489935;-0.029883934426397474;0.013167235736746719;0.4036705944379335;-1.28475478301106
HELO_3875;116.66010698243349;56.46852535472405;250.90702082647522;190.97990932564588;246.71749862314678;246.631072600303;8.800836726200053;3.678120588838729;29.54049347850998;16.13725933438066;26.594389083428435;20.29598064191007;HELO_3875;DUF349 domain protein;;;;;;;;;HELO_3875;DUF349 domain protein;1.0337813180017097;0.024698977131645705;0.0005034289107479495;-1.073567101295251;-2.1073484192969607
HELO_3876;99.95786981767198;33.283688041023176;154.62382551763156;177.2980102316717;218.2276013705174;145.11719461898508;9.501050725399894;1.8845753225420556;28.010467923453895;10.815625034517256;20.634593942667586;10.812831705076594;phbB;acetoacetyl-CoA reductase;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS15700;I;phbB; acetoacetyl-CoA reductase;1.1.1.36;phbB;acetoacetyl-CoA reductase;1.5581591555934144;0.09093698928483107;0.5853034890738584;-0.5333725847168029;-2.0915317403102174
HELO_3877;135.9214542697494;105.63854972031974;118.56849517021885;246.5528748970938;113.10351379971604;121.39075209794292;12.598219349590172;8.117281822150684;4.2283356500923475;18.634325260711847;10.237993773312539;5.681002308826458;HELO_3877;thioredoxin domain protein;COG3118;Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family;CnoX;HELO_RS15710;O;;;;HELO_3877;thioredoxin domain protein;0.36061945560754616;-0.0336572442565215;-0.10115133156465994;0.16185396924846618;-0.19876548635907998
HELO_3878;166.37521729594314;125.69726589876343;220.6099547896713;186.3802589977071;178.50587513110165;197.06539311568167;0.6257095327707964;2.081089812348657;7.480636737245748;14.757763883440855;12.500104908184609;7.185182637233352;HELO_3878;DUF306 domain protein;COG3187;Heat shock protein HslJ;HslJ;HELO_RS15715;O;;;;HELO_3878;DUF306 domain protein;0.40170053678983475;0.16204586114088837;-0.14194576456536812;-0.24289089948318843;-0.6445914362730232
HELO_3879;75.77652651502687;49.164445333193214;85.13392136623435;132.13686097821952;96.36868579124344;81.03521892870772;4.495604641753698;4.450183397648491;3.8867770933061436;1.3876325483837757;8.701932286035618;3.39244949522686;HELO_3879;DoxX domain protein;;;;;;;;;HELO_3879;DoxX domain protein;0.6140000934398522;0.0703381004861443;0.24721445669650866;-0.09557812098965357;-0.7095782144295057
HELO_3880;201.61790171103863;184.25821167361354;226.67887369011032;190.38121214466113;255.5796855795405;218.3100902185279;7.8958714476564875;4.290629780717294;25.35186588738471;8.331802886529216;43.50486904244972;15.866800200543814;HELO_3880;glyoxalase domain protein;COG0346;Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family;GloA;HELO_RS15725;Q;;;4.4.1.5;HELO_3880;glyoxalase domain protein;0.12922415265236253;0.05402823972625104;0.2264347607550361;-0.11421054550339615;-0.2434346981557587
HELO_3881;96.07164844631394;29.999878900701678;60.812965442981884;59.230261001095435;56.25065688247549;63.30295618215475;1.8715043151913073;1.8500693272728728;6.892617703511923;1.842156925160619;1.1965807455221773;5.080596854282333;HELO_3881;GNAT family acetyltransferase;COG2818;3-methyladenine DNA glycosylase Tag;Tag;HELO_RS15730;L;;;3.2.2.20;HELO_3881;GNAT family acetyltransferase;1.6467874119405792;-0.05697558449648987;-0.1675928172048584;0.5941649279424137;-1.0526224839981655
HELO_3882;71.93134736541971;14.961259084158248;28.930614487888764;27.9642702324028;31.085706777031927;30.114696157928666;6.957753157940007;0.7615456833692354;1.8726786453575355;2.2393119999343245;2.8040561890570057;1.0526606439290758;HELO_3882;DUF457 domain protein;COG1988;Membrane-bound metal-dependent hydrolase YbcI, DUF457 family;YbcI;HELO_RS15735;R;;;;HELO_3882;DUF457 domain protein;2.191964586048411;-0.055974259783828195;0.04433460489998797;1.2289428892599359;-0.9630216967884753
HELO_3883;58.77719970451779;304.39256976491174;151.37002906894273;123.91483646676267;82.56011792569439;154.314992112213;4.606049787589428;21.43793259848391;12.05696013359711;7.982519576461562;6.425847431516008;11.48263467056116;azoR1;FMN-dependent NADH-azoreductase;COG1182;FMN-dependent NADH-azoreductase;AzoR;HELO_RS15740;C;azoR1; FMN-dependent NADH-azoreductase;1.7.1.17;azoR1;FMN-dependent NADH-azoreductase;-2.352997741754897;-0.02761794065118739;-0.8943106621270864;-1.3775298757985404;0.9754678659563565
HELO_3884;292.26440868614606;1365.5419486014125;1364.0198998533933;959.8172811330102;793.2729784675918;1272.4940726924744;11.646682066071218;51.888623813619354;63.8580087143891;6.644461581252778;64.59589390263038;47.89584795940458;HELO_3884;uncharacterized protein;COG3895;Membrane-bound inhibitor of C-type lysozyme;MliC;HELO_RS15745;M;;azoR1;;HELO_3884;uncharacterized protein;-2.220255849111048;0.1001297387368254;-0.6810854167012419;-2.1185183471018973;0.10173750200915066
HELO_3885;247.02387207873116;2068.942220195008;2673.91203130606;1708.3841454534747;1504.520392299615;2844.625699129107;36.28312509021831;38.44991403160072;132.45036794640248;101.64081741247209;189.57093994191533;148.68030669731067;metE;methionine synthase MetE%2C cobalamin-independent;COG0620;Methionine synthase II (cobalamin-independent);MetE;HELO_RS15750;E;metE; methionine synthase MetE, cobalamin-independent;2.1.1.14;metE;methionine synthase MetE%2C cobalamin-independent;-3.0610396067573022;-0.08925446169793361;-0.9184836591697536;-3.520195018162066;-0.45915541140476357
HELO_3886;97.06958449176926;39.577790689685905;99.97299665913202;102.07533057514495;133.43747671292766;99.23457049026173;3.1204722331395462;2.0357576205772143;8.335497905264067;7.137620337736489;4.899356637831295;2.3213665442352007;metR;LysR family transcription regulator MetR;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS15755;K;metR; LysR family transcription regulator MetR;;metR;LysR family transcription regulator MetR;1.2731154474909552;0.010589348798993647;0.42355519581353374;-0.03150250349482686;-1.304617950985782
HELO_3887;116.93065995297609;60.95602273545791;152.71006783275678;170.17366219036825;106.55484747241071;127.28827680982276;5.9274654735209795;2.0890872707148773;14.072765597098918;8.004014908836057;36.08981807510351;47.27061208792621;HELO_3887;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS15760;T;;metR;2.7.13.3;HELO_3887;sensor histidine kinase;0.928622404639972;0.2608223223450681;-0.25431679248296657;-0.12145049754632531;-1.0500729021862973
HELO_3888;249.3348667222324;147.3870781674324;333.3675076704369;349.9980466238123;278.27465443910165;299.64258681509347;0.4886504884046932;3.1143179872186915;20.18282676489823;9.12264530261612;21.784476913757825;28.63866777119056;HELO_3888;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS15765;KT;;;;HELO_3888;response regulator/HTH domain transcription regulator;0.7544937792931066;0.15338527433276283;-0.10636473746219188;-0.2641901412273464;-1.018683920520453
HELO_3889;239.33042150865188;334.1670964760253;542.4882299901313;339.62913194400204;465.2218878660556;569.2962617784265;20.06986003472771;6.8126304095487615;35.97991992555914;15.433886425424973;38.61699585914015;66.6775165277841;nrdA;ribonucleotide-diphosphate reductase alpha subunit;COG1328;Anaerobic ribonucleoside-triphosphate reductase;NrdD;HELO_RS15770;F;nrdA; ribonucleotide-diphosphate reductase alpha subunit;1.17.4.1;nrdA;ribonucleotide-diphosphate reductase alpha subunit;-0.4798612466143526;-0.06946278407093054;-0.2906948393348241;-1.2466922967807674;-0.7668310501664148
HELO_3890;281.0421715925701;399.3126368625107;693.5037081497579;397.24211068047043;592.0486807033427;741.5978972202878;22.57430856771817;3.5943148322687444;43.01690198257137;25.75558131154687;46.93360497803831;59.61213611925444;nrdB;ribonucleotide-diphosphate reductase beta subunit;COG0208;Ribonucleotide reductase beta subunit, ferritin-like domain;NrdB;HELO_RS15775;F;nrdB; ribonucleotide-diphosphate reductase beta subunit;1.17.4.1;nrdB;ribonucleotide-diphosphate reductase beta subunit;-0.5052162648708283;-0.09659883280640003;-0.32443069599635876;-1.3966703361612165;-0.8914540712903882
HELO_3891;171.77600554714994;117.30540214295273;313.3920223378622;220.301897869262;347.6882195067556;356.675751856538;8.64678252424495;7.968692411601941;20.689790909936818;13.945788097416306;32.88154298651729;18.448398440809136;HELO_3891;uncharacterized protein;;;;;;;;;HELO_3891;uncharacterized protein;0.5463869230743388;-0.1860877062538684;-0.03671469286022777;-1.049749440497588;-1.5961363635719268
HELO_3892;64.13676979417615;38.42054850937425;49.48112735252346;34.995012173213375;47.89076895721259;51.41921322034725;3.2207303617024188;1.413755650445986;2.726809950248548;0.8282942612966329;0.5694966093546754;1.7078098900827674;HELO_3892;TonB-dependent receptor;COG1629;Outer membrane receptor protein, Fe transport;CirA;HELO_RS15785;P;;;;HELO_3892;TonB-dependent receptor;0.7245243260207559;-0.05435157070314034;-0.10053360355080887;0.3133764767574574;-0.4111478492632985
HELO_3893;40.59004453915592;25.17399553727644;25.13733167922211;26.776693018954386;29.862965163276204;22.438830141562505;0.628461767162826;1.1470716504157783;0.2167756331844456;0.5201107313275967;3.7294133702728196;3.7549085591685327;ada;bifunctional transcriptional activator / DNA repair enzyme Ada;COG2169;Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains;AdaA;HELO_RS15790;L;ada; bifunctional transcriptional activator / DNA repair enzyme Ada;2.1.1.63;ada;bifunctional transcriptional activator / DNA repair enzyme Ada;0.6681040571487991;0.15721130106845127;0.39697611065462723;0.8273376649592334;0.15923360781043439
HELO_3894;11.833490406982618;4.140573796551043;5.139552558994232;5.7056583765688815;5.658888490459354;4.8392803487421;0.33342018228217735;0.37698722508834887;0.45533083403514185;0.6792491993137777;0.33997224601586123;0.3635402572738058;HELO_3894;DUF2086 domain protein;COG3826;Uncharacterized conserved protein;;HELO_RS15795;S;;ada;;HELO_3894;DUF2086 domain protein;1.3199122941105164;0.0723429402733271;0.18949080323994671;1.1360511199481644;-0.18386117416235193
HELO_3895;26.44720435719356;12.155766709962265;20.493563610157405;34.5984063604732;27.022107767718712;19.64073307871416;1.0552650542652235;2.3343569423776636;2.228020447824458;1.056459356766042;4.984416229478276;1.564838656386125;HELO_3895;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS15800;K;;;;HELO_3895;LysR family transcription regulator;1.060963880269565;0.05841048931347359;0.44107126592919155;0.41116500000127854;-0.6497988802682864
HELO_3896;22.293948660183265;8.174228280977127;14.716809408729025;26.00417769569577;20.262734891283245;14.158208657261136;1.5742909617213126;0.35876930690050357;1.376108971011274;0.7819296492615491;1.9112242790247422;1.0645426116614636;HELO_3896;LtrA domain protein;COG4292;Low temperature requirement protein LtrA (function unknown);LtrA;HELO_RS15805;S;;;;HELO_3896;LtrA domain protein;1.3442965065430967;0.05220910192244199;0.48822790249823633;0.6198559468352487;-0.724440559707848
HELO_3897;33.848986037037754;8.14714782297505;18.30890107814457;29.347874533128163;24.825827744853285;17.375714619844985;4.233993018730903;1.2280287458112926;3.7785636263366777;1.797700664669597;2.121162505221096;2.523810960206267;HELO_3897;uncharacterized protein;;;;;;;;;HELO_3897;uncharacterized protein;1.9297228090584966;0.07146570241105987;0.49101423318804027;0.9233163236474402;-1.0064064854110564
HELO_3898;33.5023135252935;9.726980160581194;26.82860504922171;41.561336865000044;32.43794398638542;23.11273217669742;3.0444239095740864;0.1482363415664711;3.3452233933404623;4.323602602261295;3.904739666690364;2.0466804069471225;HELO_3898;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS15815;I;;;;HELO_3898;probable oxidoreductase (short-chain dehydrogenase family);1.6854491154680384;0.2067734634536773;0.47169101275482106;0.5168979741425108;-1.1685511413255276
HELO_3899;65.18659744014109;37.58490522919618;67.09774497885844;53.79403765183403;30.867828751200207;60.95660042537077;2.4084629352050198;1.5517804671804099;15.31778549520074;2.9876632255358904;2.643586911510455;15.249058582375547;HELO_3899;RND family transport protein MFP component;COG0845;Multidrug efflux pump subunit AcrA (membrane-fusion protein);AcrA;HELO_RS15820;VM;;;;HELO_3899;RND family transport protein MFP component;0.7785025435337394;0.1363490396874596;-0.959157257838136;0.09528112053979054;-0.6832214229939488
HELO_3900;29.584907311505717;22.900388000464503;32.41072271894992;25.824896108082125;16.15401905308096;29.43926499765178;1.0618417285297725;0.6974846775099306;6.106570517084903;2.531793321242486;1.0165175830447355;6.026173882659604;HELO_3900;HAE1 family transport protein;COG0841;Multidrug efflux pump subunit AcrB;AcrB;HELO_RS15825;V;;;;HELO_3900;HAE1 family transport protein;0.35578586474903773;0.134377667251945;-0.8273868949815935;0.006886380754885124;-0.3488994839941526
HELO_3901;39.4216141886016;23.845803135143427;30.56022489587728;29.27400759826553;20.510875889615257;32.928414380439285;2.8732686269939745;1.9283500210641389;7.912382376440465;0.5661276987341874;1.3722431224933218;6.357791484280167;HELO_3901;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS15830;K;;;;HELO_3901;TetR family transcription regulator;0.7021247577183578;-0.10438652240136825;-0.6574277380607834;0.25263292683151306;-0.44949183088684475
HELO_3902;122.90366242114727;73.10422790371383;133.90751396928047;124.26426586093413;134.44202863951733;138.79420591042174;5.847105189556084;6.776359458723756;7.460349954462336;4.342124993911482;11.682197465147109;1.8956500916038332;HELO_3902;NUDIX family hydrolase;COG1051;ADP-ribose pyrophosphatase YjhB, NUDIX family;YjhB;HELO_RS15835;F;;;3.6.1.55;HELO_3902;NUDIX family hydrolase;0.7415910714244527;-0.051333861585225904;-0.04562907909218339;-0.17408573398556815;-0.9156768054100208
HELO_3903;66.73151192370364;31.925580224416297;40.506927606998524;37.69565394553686;34.46758063080557;35.90450554992365;5.117386865321695;0.870343478660416;0.5547191068822384;2.108417161654207;0.9855989519013434;2.109562149910908;kefB;potassium-efflux system protein KefB;COG1226;Voltage-gated potassium channel Kch;Kch;HELO_RS15845;P;kefB; potassium-efflux system protein KefB;;kefB;potassium-efflux system protein KefB;1.0406183360916739;0.1695551849217498;-0.057296038644457425;0.8760302394612456;-0.16458809663042828
HELO_3904;34.43029948501208;31.30417439075254;26.67735571966577;34.50815066152625;23.673664550264622;26.246656266858793;1.0362443269213903;0.9444327489166452;0.9902355973254722;0.660580414006966;1.608312627368865;1.564158863610915;HELO_3904;helicase domain protein;COG1199;Rad3-related DNA helicase DinG;DinG;HELO_RS15850;L;;kefB;3.6.4.12;HELO_3904;helicase domain protein;0.13326305626793378;0.022626923242556884;-0.14310719032529828;0.37890446833773606;0.24564141206980228
HELO_3905;102.91225477325997;73.59544503231686;88.5103425756871;100.7937799785484;89.84224607598401;82.7985805803071;2.5719981112534187;0.7651541740007246;3.748586980230502;3.4306820978487136;6.034617340036283;2.447043260831704;HELO_3905;Fan1 family protein;;;;;;;;;HELO_3905;Fan1 family protein;0.47820636283072204;0.09512858278360081;0.11643757005791233;0.3103680946716034;-0.16783826815911862
HELO_3906;95.2474582886651;52.70175016109501;86.42334286007622;94.9262174509779;91.0093527312643;77.72833688149346;6.938863819931826;1.591977102469987;7.530669430623851;6.533486385932368;4.353414923599219;4.783549720259108;HELO_3906;peptidase A32 family protein;COG3577;Predicted aspartyl protease;;HELO_RS15860;R;;;;HELO_3906;peptidase A32 family protein;0.8417793354065974;0.1511355424584746;0.22489751633314814;0.28986544044401796;-0.5519138949625795
HELO_3907;61.257884165669516;37.69555121112822;133.2912074667843;117.66593767953951;125.27867378001353;130.93922497506512;4.654048137444403;4.451883886585395;14.414883859635632;7.9230086457594116;11.020357336162178;12.060988648720217;HELO_3907;YwrF family protein;COG1853;FMN reductase RutF, DIM6/NTAB family;RutF;HELO_RS15865;C;;;;HELO_3907;YwrF family protein;0.6860888369502582;0.025491313863430953;-0.0632625213212874;-1.083545082749894;-1.7696339197001523
HELO_3908;45.385700650064116;32.16174964579607;64.7426085865183;72.01961429013762;57.440648261118106;64.41516950549179;1.054399701529369;2.093124901604298;6.8517747149973625;1.7298025454689694;2.3091146320334897;3.0832057459135442;HELO_3908;major facilitator superfamily transport protein;COG2270;MFS-type transporter involved in bile tolerance, Atg22 family;BtlA;HELO_RS15870;R;;;;HELO_3908;major facilitator superfamily transport protein;0.48416000653651814;0.007203472438921388;-0.1626530479664865;-0.4959450961387235;-0.9801051026752416
HELO_3909;25.414108000829156;7.36230563174925;15.909113242064194;24.518291495458428;24.501990770543156;16.70851269192413;2.2044437598907103;0.5693896274152107;1.6632553137517865;1.6409550509049813;1.5945627508717184;0.41053761200657396;HELO_3909;alpha/beta hydrolase fold protein;COG2936;Predicted acyl esterase;;HELO_RS15875;R;;;;HELO_3909;alpha/beta hydrolase fold protein;1.6593360130416284;-0.06664204461135448;0.5261668254139842;0.5768656435306347;-1.0824703695109936
HELO_3910;15.398115223500335;6.193934151411771;12.93120586174341;21.144960052884567;16.159233063864157;12.398309738846372;0.266305222507456;0.5402441803430779;1.587961245084268;0.3472999557435164;1.169541170192003;0.48157974056965486;HELO_3910;ATP-grasp fold protein;COG0458;Carbamoylphosphate synthase large subunit;CarB;HELO_RS15880;EF;;;;HELO_3910;ATP-grasp fold protein;1.1886771438603305;0.05626913134913725;0.3569340634186027;0.2914789937651703;-0.8971981500951602
HELO_3911;73.46721683137757;12.108079220837277;46.85207913753852;56.84116333481839;42.269796898405154;39.6146057224855;5.698600766135851;2.9708733081288785;6.046523259513689;6.0662111281676445;5.381007496680711;1.232694670620909;HELO_3911;uncharacterized protein;;;;;;;;;HELO_3911;uncharacterized protein;2.5061491414905297;0.2365829710209555;0.09136170990552195;0.8746067995880189;-1.6315423419025108
HELO_3912;181.09344355125822;58.02592206262491;131.86928212260838;145.15636867513854;142.71567583048142;128.9828758641201;7.394778418267206;3.0792198201787913;7.612180854197323;3.153521097583508;11.900856803447418;5.574277043696815;HELO_3912;TelA domain protein;COG3853;Uncharacterized conserved protein YaaN involved in tellurite resistance;YaaN;HELO_RS15890;V;;;;HELO_3912;TelA domain protein;1.6252583990951655;0.03168603536477388;0.14489585977413988;0.4863574046353971;-1.1389009944597683
HELO_3913;195.64309646230913;57.77647960620192;176.3508914473716;196.56307952729068;159.40923360611515;170.2445135108829;9.951082663298694;2.493052046048305;19.94873606719577;12.425723243922747;16.439314787014695;0.5196238645685793;HELO_3913;uncharacterized protein;;;;;;;;;HELO_3913;uncharacterized protein;1.7422686815138269;0.05054881551806378;-0.09430057666135472;0.19952177213552336;-1.5427469093783035
HELO_3914;57.17925901017687;27.975258590094665;80.4315297896422;79.49966367128914;76.95066755938929;76.17037485972102;4.795206380393033;3.1702155551810396;7.044108610732938;4.060576963972401;4.901777277642646;5.3911102817264505;HELO_3914;HTH domain protein;COG2197;DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains;CitB;HELO_RS15900;KT;;;;HELO_3914;HTH domain protein;1.0056833852845077;0.07754039160725767;0.014514264288228773;-0.4075421918151383;-1.413225577099646
HELO_3915;16.53057962888575;6.125958539219982;7.3344888505612404;11.099045670113071;10.055232790561835;7.096224749789158;1.31832753723621;0.6920280748008204;0.1596866895577107;0.2222719132899205;1.2292027117254554;0.5071587896177542;HELO_3915;DUF2182 domain protein;COG5486;Predicted metal-binding membrane protein;;HELO_RS15905;S;;;;HELO_3915;DUF2182 domain protein;1.2987177033608388;0.04184438271109281;0.44940815970812364;1.114552453310067;-0.18416525005077178
HELO_3916;29.57536702893859;6.925022305016038;24.771080064263533;47.179539757737324;37.38197482181877;23.146091780741045;1.5988230931605167;0.6276362265352137;2.1364994736629863;3.709696185639228;5.232362111157988;1.0924801432814417;HELO_3916;DUF1326 domain protein;COG5588;Uncharacterized conserved protein, DUF1326 domain;;HELO_RS15910;S;;;;HELO_3916;DUF1326 domain protein;1.9478829162302222;0.09396330436856193;0.6686392453545409;0.34058011972333446;-1.6073027965068878
HELO_3917;8.231552116008721;4.274223878566645;7.841534141250693;11.035293991951397;9.640190919026184;7.856455747214954;0.5550483960865074;0.24763760254943748;0.7012511427320189;1.2486111243212341;0.8518434247962035;0.5111307750404511;HELO_3917;amidohydrolase domain protein;COG1574;Predicted amidohydrolase YtcJ;YtcJ;HELO_RS15915;R;;;;HELO_3917;amidohydrolase domain protein;0.8076144193901893;-0.002432743171780327;0.2647226683784454;0.059843766810160126;-0.7477706525800292
HELO_3918;4.795368239430659;3.138989682316591;4.977386925734874;5.659356678127807;6.205376935614343;4.996282156054893;0.42284465040930475;0.3601677384653382;0.6188893458827249;0.7008639299436715;1.0161949913482609;0.3599139666423154;puuC2;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS15920;I;puuC2; aldehyde dehydrogenase;1.2.1.99;puuC2;aldehyde dehydrogenase;0.48562168119943117;-0.004553337414196168;0.26500563308785763;-0.049167937719839294;-0.5347896189192705
HELO_3919;9.627343279881414;6.290817184402068;9.318670086434006;10.885563099638782;10.711078794300711;8.175806105497855;0.6102945135267637;0.9205090410522688;0.8851047381326498;1.1554814396586899;2.0100302218572197;0.646724969594736;HELO_3919;probable N-carbamoyl-L-amino acid hydrolase;COG0624;Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase;ArgE;HELO_RS15925;E;;puuC2;3.5.1.6,3.5.1.87;HELO_3919;probable N-carbamoyl-L-amino acid hydrolase;0.5436285520409374;0.16935023102846625;0.35196716818367424;0.21187417277426857;-0.33175437926666884
HELO_3920;6.219888961246274;3.4246646610305387;4.1634232527126;3.9588989525035347;5.762874268105626;4.739311797181246;0.42737760229831484;0.13133404297468093;0.5479263121811653;0.3538794270921533;0.31088259255703293;0.11641244737753412;HELO_3920;pyridoxal phosphate-dependent aminotransferase;COG0161;Adenosylmethionine-8-amino-7-oxononanoate aminotransferase;BioA;HELO_RS15930;H;;;;HELO_3920;pyridoxal phosphate-dependent aminotransferase;0.7064085297034293;-0.1525498906324274;0.23675877894120134;0.3310988960387595;-0.37530963366466974
HELO_3921;2.1507786708542795;2.414711611354884;2.6087720889815404;2.2050936674877737;3.173448493257704;2.986337705784702;0.2435749311301628;0.5200996258671896;1.0806936738653665;0.36227065675489795;0.4089353444265726;0.4325756936309779;HELO_3921;NhaC family sodium/proton antiporter domain protein;COG1757;Na+/H+ antiporter NhaC/MleN;NhaC;HELO_RS15935;C;;;;HELO_3921;NhaC family sodium/proton antiporter domain protein;-0.11605532663238383;-0.14355590131789198;0.06617603153019447;-0.33935551985137846;-0.22330019321899464
HELO_3922;23.469407818545715;9.67519468755476;18.142613624413737;17.748288138495976;30.63025008959697;19.441992720268363;1.088984480586333;1.3197926678525143;1.9150862416325767;1.408499228958933;0.8510505800945083;0.9906194983195272;aguA;agmatine deiminase;COG2957;Agmatine/peptidylarginine deiminase;AguA;HELO_RS15940;E;aguA; agmatine deiminase;3.5.3.12;aguA;agmatine deiminase;1.1967168062756772;-0.09474801879074057;0.629769123297339;0.2594433478347744;-0.9372734584409028
HELO_3923;54.829019035268885;22.574309871950515;41.80443442899866;105.48636271038517;28.260849208740314;43.31859014110713;11.992856138938766;0.3106715949654146;2.0770633470451334;7.149473135378113;1.78580710630714;4.393194563407531;yhbW;YhbW family protein;COG2141;Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase);SsuD;HELO_RS15950;HR;yhbW; YhbW family protein;;yhbW;YhbW family protein;1.2437996697008975;-0.050151723382039215;-0.5989403472378747;0.33310321969047063;-0.9106964500104269
HELO_3924;171.28145462032887;66.71084235463285;123.34444813001949;154.97885620746243;135.62560645691823;119.16850272443985;8.061356103917959;2.7818447791418897;14.652443838061194;7.021016349428368;11.057619993990333;8.852444715069083;HELO_3924;uncharacterized protein;;;;;;;;;HELO_3924;uncharacterized protein;1.3473086375420174;0.04928329204166371;0.18516909789015124;0.5197086079305517;-0.8276000296114656
HELO_3925;58.55250913253135;34.35167869119428;92.30035837159265;103.69776220930574;72.19518686786476;91.49972038441582;2.258726542374303;2.51796134777417;6.4861801704097966;4.923819683145561;1.517538248619416;5.8627011628080945;HELO_3925;ion channel domain protein;;;;;;;;;HELO_3925;ion channel domain protein;0.7523835708834579;0.012433618014249248;-0.3377002209247273;-0.6352867099395372;-1.387670280822995
HELO_3926;166.90620082794536;95.75439570597159;148.82548743580776;112.27068482931799;89.63803622501253;161.60375011198897;15.543058216765804;7.28172805733763;6.022507624801504;3.192308077827128;7.819477127686257;10.460754384447522;HELO_3926;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS15965;K;;;;HELO_3926;LysR family transcription regulator;0.7952563986457539;-0.1180774629919128;-0.8431720215108491;0.04629497992300102;-0.7489614187227529
HELO_3927;18.72126672293138;9.734269525204757;14.691689020071811;15.224451099981843;14.959599889200879;15.823489437238733;1.8277796213271533;0.30529336824704156;1.0741569607765944;0.42927912104575505;0.8457159638428231;0.2356752389898363;HELO_3927;glycoside hydrolase domain protein;;;;;;;;;HELO_3927;glycoside hydrolase domain protein;0.877528202796924;-0.10047632334359502;-0.07605248931629305;0.22927524825714674;-0.6482529545397773
HELO_3928;32.77370712864796;17.017132009333164;35.209027736601975;36.52835201202638;30.999898376449124;31.588537984459197;1.497404712875105;0.8209761236421099;6.781659500592577;6.430969971826479;1.8276050251700804;1.665743635851003;HELO_3928;peptidase M48 family protein;COG4783;Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains;BepA;HELO_RS15975;MO;;;;HELO_3928;peptidase M48 family protein;0.9065311643088094;0.1519848088607212;-0.026297306592616643;0.05153591357103959;-0.8549952507377698
HELO_3929;14.790510557904378;6.479548681954282;10.007081182290245;13.394510938929734;12.998143564337218;10.711505799186645;0.9896535611679153;0.8800776740827452;0.9222732092466168;0.2891801790964783;0.870440747895599;0.8322249355126011;pobA;p-hydroxybenzoate hydroxylase;COG0654;2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases;UbiH;HELO_RS15980;CH;pobA; p-hydroxybenzoate hydroxylase;1.14.13.2;pobA;p-hydroxybenzoate hydroxylase;1.0780346936827692;-0.0894946303353854;0.25730892811302475;0.43113123758010286;-0.6469034561026663
HELO_3930;8.231254414497572;3.455890285856654;7.903692354369485;8.307337523894553;9.012519389245325;8.749259511401581;0.5647974210151383;0.27585920694748767;1.033075471142197;0.5351697089593618;0.7598629105719863;0.9884867327318697;HELO_3930;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS15985;K;;pobA;;HELO_3930;AraC family transcription regulator;1.0508129951065048;-0.13088890085865668;0.03844048575360537;-0.07876593975779533;-1.1295789348643002
HELO_3931;17.798816120014013;12.310830528937297;77.84839935557223;66.0539263640518;118.66487581076298;77.78111172256718;2.4392849215312444;0.46500569709439077;1.7641215788154025;4.652236728404596;7.841437217414891;5.167221596749575;HELO_3931;beta-lactamase domain protein;COG1234;Ribonuclease BN, tRNA processing enzyme;ElaC;HELO_RS15990;J;;;3.1.26.11;HELO_3931;beta-lactamase domain protein;0.49804121818096103;0.0012316924626860626;0.6030780718484241;-2.067207966579838;-2.565249184760799
HELO_3932;92.63335544528793;70.1794342764091;115.95516692836581;127.67727114540584;101.56300943823311;109.50530299528965;6.95291723193385;5.332604332718115;8.807923932942114;4.138721786144532;11.705136535123199;6.970783654305377;vdh;vanillin dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS15995;I;vdh; vanillin dehydrogenase;1.2.1.67;vdh;vanillin dehydrogenase;0.395562092762769;0.08183999530384689;-0.10760510446752303;-0.23902113975743244;-0.6345832325202014
HELO_3933;67.73946685535589;41.078139056939584;48.91075082767062;70.38110592944322;35.342223313284876;42.204696657621916;1.7285742304452476;0.8681761822308207;3.9069659552583653;9.965266894025582;2.5213074190722886;0.7824958167253718;HELO_3933;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS16000;G;;vdh;;HELO_3933;TRAP transporter substrate-binding protein;0.7080677606108141;0.2081624549301786;-0.24954146989075987;0.6699505100635683;-0.038117250547245796
HELO_3934;14.034343551230057;7.486525464315686;13.739648550748546;21.785838963490875;13.871722381370885;13.335396499964075;1.791402726411922;0.5956286434430502;0.7219312166751534;0.08185334728592769;0.6127326027202636;1.746367378523609;mdlC;benzoylformate decarboxylase;COG0028;Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme;IlvB;HELO_RS16005;EH;mdlC; benzoylformate decarboxylase;4.1.1.7;mdlC;benzoylformate decarboxylase;0.8250159619320021;0.04012031715529174;0.05298993568493726;0.06868006813399319;-0.7563358937980089
HELO_3935;16.17956025122115;17.75941281156982;26.38846342609544;47.42684178351444;27.120837056148943;25.90768735641657;3.8030218469505335;0.6280092538883378;3.0091325841327214;2.2604062824701234;0.986217463606669;1.1807146693529582;HELO_3935;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS16010;K;;mdlC;;HELO_3935;LysR family transcription regulator;-0.1269215627748963;0.025549928313619574;0.06362113835462768;-0.6473252925521455;-0.5204037297772492
HELO_3936;29.796816609445898;19.984727828380514;37.780346837134935;27.303647703947345;51.79363595076581;35.30073175445656;2.568568651346315;0.5812185186615697;0.4006961223404331;0.7367039060256515;1.5250100205383479;2.7223956939206424;HELO_3936;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS16015;G;;;;HELO_3936;TRAP transporter large transmembrane protein;0.5534414792076232;0.09532707590343303;0.5403653987556769;-0.23721739971314548;-0.7906588789207687
HELO_3937;23.79807551207595;18.01948371503524;19.152127435236476;13.015094401252648;26.66924140592171;19.742088721361338;2.9757683059470392;0.6512848161858009;0.561370039259918;2.64405909933487;3.0502012847336593;2.428030478540381;HELO_3937;TRAP transporter small transmembrane protein;;;;;;;;;HELO_3937;TRAP transporter small transmembrane protein;0.38275007798072824;-0.041629030043006665;0.41572191045270657;0.2576669822999458;-0.12508309568078246
HELO_3938;66.69009050372209;33.77360784812107;82.0694343658564;63.36434736795906;114.6536024883107;85.04590374047065;4.359722304726748;3.076045889140456;4.408827733843107;1.6454061918847254;1.2221951064890906;3.964571790849212;HELO_3938;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS16025;G;;;;HELO_3938;TRAP transporter substrate-binding protein;0.960951887778771;-0.05078878276090126;0.4266317863371034;-0.34616186785927194;-1.307113755638043
HELO_3939;38.419754002974464;20.27493488198179;47.72987137437758;44.91720569283371;45.42883653432592;44.34443248596411;2.595853579623792;0.860054046014453;5.65821518182609;1.0164581966777428;5.404037388436952;2.3982017156501354;HELO_3939;GntR family transcription regulator;COG1802;DNA-binding transcriptional regulator, GntR family;GntR;HELO_RS16030;K;;;;HELO_3939;GntR family transcription regulator;0.8897640572049035;0.10388099088338709;0.03409570512714222;-0.20200665022330178;-1.0917707074282053
HELO_3940;6.189200268874263;10.25014075969345;25.750354243293106;12.62145028191029;61.912749528834205;27.53454605471949;0.4842346710061478;0.6920806945642072;5.960646981129572;1.3524775505395314;2.500319861695422;7.507891683336584;vanA;vanillate O-demethylase oxygenase subunit;COG4638;Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit;HcaE;HELO_RS16035;PR;vanA; vanillate O-demethylase oxygenase subunit;1.14.13.82;vanA;vanillate O-demethylase oxygenase subunit;-0.6460398538845245;-0.09315161528569504;1.140642802940703;-1.9888064135022998;-1.3427665596177754
HELO_3941;3.1250587301046227;9.20986324511266;27.464730471689776;11.286414975229038;65.09755748566135;27.195878821366687;0.5101618984863365;0.59638352066046;4.823429269537554;1.6264697737039766;3.6420800499055295;7.757318421723637;HELO_3941;probable oxidoreductase (homolog to vanillate O-demethylase oxidoreductase);COG1018;Flavodoxin/ferredoxin--NADP reductase;Fpr;HELO_RS16040;C;;vanA;;HELO_3941;probable oxidoreductase (homolog to vanillate O-demethylase oxidoreductase);-1.3074769774840989;0.01369112893227431;1.2291126503654137;-2.7729977453547354;-1.4655207678706366
HELO_3942;3.29841933194362;9.941920677356142;39.33543040137899;20.259824913569556;87.00713300933539;39.351711101874834;0.2864809907689825;0.30834388390117795;5.916821207405029;2.825783364736127;1.269805790969091;9.929633419320664;HELO_3942;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS16045;G;;;;HELO_3942;TRAP transporter substrate-binding protein;-1.3479878654205382;-0.0005822014697436373;1.1249906075946141;-3.2307517150992155;-1.8827638496786774
HELO_3943;3.6302186978785937;2.48041347608102;5.599693617120053;5.190958459484437;9.830214006615975;6.98953188551508;0.3473879774014386;0.3846241024427991;0.6415437754617657;0.5109194104173838;1.0416436820891521;0.6298045046639388;HELO_3943;enoyl-CoA hydratase;COG1024;Enoyl-CoA hydratase/carnithine racemase;CaiD;HELO_RS16050;I;;;4.2.1.155;HELO_3943;enoyl-CoA hydratase;0.4118216278694722;-0.27571192608191986;0.438878869264272;-0.7870306391934534;-1.1988522670629256
HELO_3944;3.858133542344182;2.763718225299046;4.833173408862574;5.239712487126226;9.780334870240237;7.0786606153831;0.34850049532531374;0.19849092377785213;0.5454467322213181;0.594443445796518;0.8282076045444096;0.4895142649068259;HELO_3944;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS16055;I;;;;HELO_3944;probable oxidoreductase (short-chain dehydrogenase family);0.36824352466859445;-0.46983516090254795;0.4162139640033007;-0.7337139762950557;-1.1019575009636502
HELO_3945;3.918312234037478;1.7011538235890813;2.714122741828415;3.03445066383053;3.9385272663870405;2.780317373622095;0.6382239828070702;0.2338108304456932;0.10236722499053577;0.12723728322155753;0.1076312164676933;0.18067369020445287;HELO_3945;acyl-CoA dehydrogenase family protein;COG1960;Acyl-CoA dehydrogenase related to the alkylation response protein AidB;CaiA;HELO_RS16060;I;;;1.3.8.-;HELO_3945;acyl-CoA dehydrogenase family protein;0.864587525999569;-0.025485866601761886;0.3855735154838136;0.37965596598745077;-0.48493156001211823
HELO_3946;47.59351443841928;6.3177001251844445;22.499437803728103;27.646915340183938;14.618152317243046;16.34497413939205;2.7322760445989576;0.8051556394651679;1.6381146646995073;2.8975565187726353;1.914892484742181;1.9773766872331604;HELO_3946;porin domain protein;;;;;;;;;HELO_3946;porin domain protein;2.7313015752967735;0.43810855279976924;-0.15129390199002524;1.486246086919314;-1.2450554883774596
HELO_3947;0.7283327446533755;0.5653303786152079;0.9496050262181877;0.8373825001256776;1.390276700410409;1.2927714321414971;0.047985431748701346;0.2338480713210283;0.3133965902961651;0.2049216563783911;0.08968240638376986;0.6102118583761635;HELO_3947;thiolase domain protein;COG0183;Acetyl-CoA acetyltransferase;PaaJ;HELO_RS16070;I;;;2.3.1.9;HELO_3947;thiolase domain protein;0.1429138124295396;-0.23391066334329202;0.060085096555225315;-0.40771154196345427;-0.5506253543929939
HELO_3948;0.4768937572073013;0.5050207182887158;0.7283872969778179;0.7794325876273608;1.1438197269475534;0.8147509872785162;0.08569895638034028;0.15377787151582073;0.026681063131697016;0.32767760018147324;0.23343084510343892;0.09244819288737215;ydiF;acetate CoA-transferase YdiF;COG4670;Acyl CoA:acetate/3-ketoacid CoA transferase;YdiF;HELO_RS16075;I;ydiF; acetate CoA-transferase YdiF;2.8.3.1;ydiF;acetate CoA-transferase YdiF;-0.027217300244055775;-0.07034506828603948;0.24041199409577318;-0.2972055538940933;-0.26998825365003754
HELO_3949;3.444355093126759;2.5683775572113774;5.938532888696439;4.908670326903956;5.578545394561156;5.846446846420197;0.4592783445105426;0.39733592902583487;1.6156241463533343;0.993024554757827;0.5934767889062552;0.7270805455280538;HELO_3949;TRAP transporter large transmembrane protein;COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS16080;G;;ydiF;;HELO_3949;TRAP transporter large transmembrane protein;0.3167058194310912;0.01927519014091006;-0.057586835846030304;-0.6233813665206136;-0.9400871859517048
HELO_3950;6.714691230114;3.825896478134903;4.28146279923222;3.905028442635087;3.857458417240021;5.77395982121774;0.403954524358644;0.6395611858676329;0.7590287738327325;0.5276156118082959;0.33166342884260264;0.4544909101950204;HELO_3950;TRAP transporter small transmembrane protein;;;;;;;;;HELO_3950;TRAP transporter small transmembrane protein;0.6768114479024652;-0.35906186359520165;-0.4797977841884751;0.1876089863540944;-0.48920246154837077
HELO_3951;8.819232794058552;4.768191761852833;20.68389449977514;17.418561934778868;20.255042401677944;20.648108436644794;0.4202983247794686;0.5848525746884038;2.7972728719069764;0.915373372300102;1.2212690710964227;3.883713836099997;HELO_3951;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS16090;G;;;;HELO_3951;TRAP transporter substrate-binding protein;0.7674911795255288;0.002382921815287986;-0.026435833977380696;-1.1405587589992252;-1.908049938524754
HELO_3952;6.301421696233478;5.315589163698262;3.637348872187213;4.560943717496767;5.6000418624032475;4.137770042628884;1.2801574308497337;0.7811255637605982;0.7694682197014009;0.3473063559120182;0.9495689376264591;1.1633845929973494;HELO_3952;thioesterase domain protein;COG0824;Acyl-CoA thioesterase FadM;FadM;HELO_RS16095;I;;;3.1.2.23;HELO_3952;thioesterase domain protein;0.20926008040472066;-0.14784205311974663;0.36133285590980213;0.5070350864504132;0.2977750060456925
HELO_3953;7.97611193715493;3.825095785935998;6.4361850470971875;5.68579325901803;7.1206374729842485;7.157984240474483;0.03408678139411445;0.02626708819237964;0.2734703595412753;0.8217244702572055;0.8457347751584988;0.4839147748694473;HELO_3953;acyl-CoA synthetase family protein;COG0318;O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming);MenE/FadK;HELO_RS16100;I;;;6.2.1.34;HELO_3953;acyl-CoA synthetase family protein;0.8955330847868046;-0.13365004843612383;-0.006619736207612803;0.13787794712900592;-0.7576551376577987
HELO_3954;56.588473678530846;45.54632238988998;115.81914219071454;113.45925007220768;110.31894598697782;104.64003701844238;4.228212399847552;1.3853250822537204;4.994624974480793;8.48066400514001;5.2229336794611845;11.648867671846387;HELO_3954;MarR family transcription regulator;COG1846;DNA-binding transcriptional regulator, MarR family;MarR;HELO_RS16105;K;;;;HELO_3954;MarR family transcription regulator;0.3071129000263859;0.1451199839753512;0.07554244165609258;-0.875304721617642;-1.1824176216440279
HELO_3955;26.210210717038006;20.09142051764331;29.165473556763782;25.42360920397205;35.442592794549206;34.69701528668466;1.7667745857438288;0.4176456137741374;1.0624048955826455;1.5256422864760328;2.3695107535596898;3.40212045303223;pcaG;protocatechuate 3%2C4-dioxygenase alpha subunit;COG3485;Protocatechuate 3,4-dioxygenase beta subunit;PcaH;HELO_RS16110;Q;pcaG; protocatechuate 3,4-dioxygenase alpha subunit;1.13.11.3;pcaG;protocatechuate 3%2C4-dioxygenase alpha subunit;0.3674918642919609;-0.24290522120907543;0.0298221546517361;-0.3916553231712854;-0.7591471874632463
HELO_3956;22.350083092431436;17.14133141744549;22.637034928495193;16.87291924212469;22.410728057447233;23.225370142579965;0.6633373687229545;0.6953713831431633;1.4548773561401411;1.6408577106530002;0.20157316100321926;2.451056462067878;pcaH;protocatechuate 3%2C4-dioxygenase beta subunit;COG3485;Protocatechuate 3,4-dioxygenase beta subunit;PcaH;HELO_RS16115;Q;pcaH; protocatechuate 3,4-dioxygenase beta subunit;1.13.11.3;pcaH;protocatechuate 3%2C4-dioxygenase beta subunit;0.3641473427063344;-0.03546963628834909;-0.04934890696852268;-0.05309102508776142;-0.41723836779409584
HELO_3957;27.925823044472125;23.903329570220603;24.008679540670737;21.304379955290145;23.70269082860678;22.568564277650324;0.7249977542113238;3.115014098564136;1.2364023793662755;2.5525792509657608;1.2661147625363574;0.14610514863614862;HELO_3957;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS16120;K;;pcaH;;HELO_3957;LysR family transcription regulator;0.21601936658832877;0.08556500832259673;0.06780432421837546;0.2954941329694769;0.07947476638114814
HELO_3958;51.782866872615706;40.37066505524224;64.68292985529042;59.14154777867763;58.21495994901971;62.45093895657883;1.2945235301773015;2.470686149717429;1.6142772846395053;4.430485149987443;3.799081395022145;1.7290913085617745;HELO_3958;alpha/beta hydrolase fold protein / AhpD domain protein;COG0599;Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family;YurZ;HELO_RS16125;R;;;3.1.1.24,4.1.1.44;HELO_3958;alpha/beta hydrolase fold protein / AhpD domain protein;0.35146156214376845;0.04987696801791852;-0.09967981195183828;-0.2655718014571944;-0.6170333636009628
HELO_3959;15.669670595824988;21.5871478717791;16.524239534195193;12.329817777406154;13.32483070282442;16.200529766182942;1.2407358338832544;1.8626014461324727;1.7243421165854576;0.21324925155691835;0.7347377149911964;1.1756035717293751;HELO_3959;AtoE family transport protein;COG2031;Short chain fatty acids transporter;AtoE;HELO_RS16130;I;;;;HELO_3959;AtoE family transport protein;-0.43827651403723955;0.026898839956267295;-0.2639349110931444;-0.045227403810847555;0.393049110226392
HELO_3960;27.62579253486801;36.11620553202318;49.503271748175855;31.563679048600914;46.62648816545618;46.9813695477609;2.2000476868341843;3.4682360473311875;2.149838069571478;3.768003936867507;4.439909916832995;6.253246661811804;pcaF;beta-ketoadipyl-CoA thiolase;COG0183;Acetyl-CoA acetyltransferase;PaaJ;HELO_RS16135;I;pcaF; beta-ketoadipyl-CoA thiolase;2.3.1.16;pcaF;beta-ketoadipyl-CoA thiolase;-0.3747335919704309;0.07390251532344028;-0.010710164916607035;-0.7451587012538763;-0.3704251092834454
HELO_3961;19.77977445669435;28.653073948410334;29.423341856211845;18.641321572708176;28.399891622528116;29.512791887868076;1.0955771579986282;1.820486377928005;3.464104076792453;1.6953131920312206;1.6346080774959788;2.155351125076595;catJ;3-oxoadipate CoA-transferase subunit B;COG2057;Acyl-CoA:acetate/3-ketoacid CoA transferase, beta subunit;AtoA;HELO_RS16140;I;catJ; 3-oxoadipate CoA-transferase subunit B;2.8.3.12;catJ;3-oxoadipate CoA-transferase subunit B;-0.5130016723398958;-0.004235556207504487;-0.05360335417869955;-0.5542341956708841;-0.04123252333098826
HELO_3962;18.487780935160654;22.73652091394503;31.588902938734886;21.556827479919203;31.036724615848613;35.319621087196744;2.658282120941897;0.6352277531055819;0.7320181241706737;0.9597831380028162;1.2382326025247694;1.7614290388906897;catI;3-oxoadipate CoA-transferase subunit A;COG1788;Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit;AtoD;HELO_RS16145;I;catI; 3-oxoadipate CoA-transferase subunit A;2.8.3.12;catI;3-oxoadipate CoA-transferase subunit A;-0.2845386722793357;-0.15636836493942674;-0.1810224950367969;-0.8981793305457453;-0.6136406582664096
HELO_3963;34.94611013901569;25.64481222129345;30.706902304015774;29.378803598846257;29.39490575342614;31.457705645679393;1.2611960582690391;1.3484131066091471;2.122638171574996;3.0167079333716003;2.454365562166279;1.2595958090995336;pcaB;3-carboxy-cis%2Ccis-muconate cycloisomerase;COG0015;Adenylosuccinate lyase;PurB;HELO_RS16150;F;pcaB; 3-carboxy-cis,cis-muconate cycloisomerase;5.5.1.2;pcaB;3-carboxy-cis%2Ccis-muconate cycloisomerase;0.4319809939932284;-0.033764086841232555;-0.09473147759789136;0.14727463679344943;-0.284706357199779
HELO_3964;77.79635839820207;35.421281654262;71.1686681780425;58.009149904624174;52.53813310692118;69.02571907420908;0.6738750465145158;1.6052253801438072;10.096155253893244;3.446795474461301;2.253275121336241;1.598300291710304;pcaR;IclR family transcription regulator PcaR;COG1414;DNA-binding transcriptional regulator, IclR family;IclR;HELO_RS16155;K;pcaR; IclR family transcription regulator PcaR;;pcaR;IclR family transcription regulator PcaR;1.113347265331523;0.043487738086870564;-0.3873180604167379;0.1702440635553666;-0.9431032017761565
HELO_3965;22.814550014262966;8.127042834638116;10.194821816829752;9.457677769204402;7.343636728046846;10.299618644721841;1.0791313196221015;0.7958532374700646;0.11942987520688053;0.29838009792493425;1.7510248360472762;2.0405498123020407;HELO_3965;AEC family transport protein;COG0679;Predicted permease, AEC (auxin efflux carrier) family;YfdV;HELO_RS16160;R;;pcaR;;HELO_3965;AEC family transport protein;1.3836238813558484;-0.013442517763188722;-0.4375258322562021;1.075569205262945;-0.30805467609290327
HELO_3966;2.5945528482589997;0.9653613523340431;6.350157635209282;4.332365387382153;10.9618689840066;6.118379379168054;0.11282884937817879;0.10057425216002777;0.6359488712131273;0.3927908019976318;2.8179464999271726;1.1739757075448034;tktA1;transketolase;COG0021;Transketolase;TktA;HELO_RS16170;G;tktA1; transketolase;2.2.1.1;tktA1;transketolase;0.8710177233178943;0.04622636668004532;0.748822091766904;-0.9857365095395647;-1.856754232857459
HELO_3967;0.9454952864234948;0.16760454589294738;4.849349628805208;4.3278454332067;5.263950554563827;4.843531758338784;0.1867943136872688;0.09104992431332097;0.6161133313719247;0.7109704652016416;1.2890541546301462;1.2574615111630534;talA2;transaldolase;COG0176;Transaldolase/fructose-6-phosphate aldolase;TalA;HELO_RS16175;G;talA2; transaldolase;2.2.1.2;talA2;transaldolase;0.7365857520505927;0.0014356450365271556;0.10023224479139259;-1.5867030948213139;-2.3232888468719066
HELO_3968;34.15921633864996;9.859162671738735;28.095396877897304;31.60349239234579;41.72819105264157;28.95651272608579;1.1478094115708792;0.8846069511605111;1.5120370206070926;1.1005198750849294;4.062719124514265;2.0596264511204403;HELO_3968;ABC-type transport system permease protein;COG1172;Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component;AraH;HELO_RS16180;G;;talA2;;HELO_3968;ABC-type transport system permease protein;1.6949900506004347;-0.04207876228386098;0.5123185524547598;0.23103322701438422;-1.4639568235860505
HELO_3969;27.677416834357256;13.766161879274634;18.655233392997157;16.857996097479468;27.75285782963739;19.90013134584783;2.167627685955786;2.4237448880351873;0.2450384315081219;1.3626071198751024;1.8873613833865694;0.06933880692050193;HELO_3969;ABC-type transport system ATP-binding protein;COG1129;ABC-type sugar transport system, ATPase component;MglA;HELO_RS16185;G;;;;HELO_3969;ABC-type transport system ATP-binding protein;0.9576201969844513;-0.08859851396018481;0.46019334793254085;0.45640306787520135;-0.50121712910925
HELO_3970;105.97805270812573;41.845136981000984;84.19578886468925;50.61917308115264;156.60971102517354;95.54543856850137;7.402022131978996;4.428469975996089;4.219307007439715;2.305574959465484;5.194525327212127;8.84917197497624;HELO_3970;ABC-type transport system periplasmic substrate-binding protein;COG1879;ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain;RbsB;HELO_RS16195;G;;;;HELO_3970;ABC-type transport system periplasmic substrate-binding protein;1.3201114784327226;-0.18042597716863007;0.7070764246525538;0.14803484441152115;-1.1720766340212014
HELO_3971;53.31886944212953;28.81193299818446;44.163954406181865;32.02835107254729;63.644731812124114;46.49372393462696;1.544251491437692;1.4118320042136683;5.6594116265734655;4.230696422015815;0.9665833264838621;6.410117766871006;HELO_3971;LsrR family transcription regulator;COG2390;DNA-binding transcriptional regulator LsrR, DeoR family;DeoR;HELO_RS16210;K;;;;HELO_3971;LsrR family transcription regulator;0.8655635302292852;-0.0725650716451467;0.44479592228125764;0.19371657168892575;-0.6718469585403595
HELO_3972;5.155176865094752;2.3615762276180985;3.229447875826444;3.7866188746153226;3.125505688388436;3.028390456525692;0.18976423729293032;0.5114388280471363;0.32005773950737826;0.450468592158111;0.38068502710526786;0.615892139750009;glpK2;glycerol kinase;COG0554;Glycerol kinase;GlpK;HELO_RS16215;C;glpK2; glycerol kinase;2.7.1.30;glpK2;glycerol kinase;0.8726624475159002;0.07026581706578261;0.034367445074911185;0.6115967871793768;-0.26106566033652334
HELO_3973;4.551252817043143;2.8150706972377004;3.5833448359712583;4.8228437801564;3.9770835752882863;4.307786511740002;0.41397619526710944;0.3333380833928012;0.3118948844386117;0.25875865493717953;0.34198387581550804;0.6024875204151473;HELO_3973;transketolase_Cterm domain protein;COG3958;Transketolase, C-terminal subunit;TktA2;HELO_RS16220;G;;glpK2;2.2.1.1;HELO_3973;transketolase_Cterm domain protein;0.5411036063529258;-0.21170951072842925;-0.09280973122803449;0.06470305409299915;-0.4764005522599266
HELO_3974;5.269108089957496;4.1573837614967095;5.156404122695878;5.243438651956288;3.0770865005638317;3.3825349046206696;0.46683735329118503;1.989859370706824;1.8656149060557876;2.0359445366066513;0.9180506280500211;1.0574987955217385;HELO_3974;transketolase_Nterm domain protein;COG3959;Transketolase, N-terminal subunit;TktA1;HELO_RS16225;G;;;2.2.1.1;HELO_3974;transketolase_Nterm domain protein;0.28162080384569377;0.49032235575425087;-0.10422701559215453;0.5164946231253942;0.2348738192797004
HELO_3975;96.43940348061857;43.045124059948726;84.74209245825892;76.85761308940839;105.43383713582955;89.78783289321154;3.974094161092128;0.5788588196823099;6.408760381363592;3.494401742765695;12.171164556391878;4.668290054064526;aroQ;3-dehydroquinate dehydratase;COG0757;3-dehydroquinate dehydratase;AroQ;HELO_RS16230;E;aroQ; 3-dehydroquinate dehydratase;4.2.1.10;aroQ;3-dehydroquinate dehydratase;1.1455229842602561;-0.08249533965541644;0.22938601115101953;0.10200633625279121;-1.043516648007465
HELO_3976;106.66365984794702;58.835021535579195;83.40761403262064;86.56768183428859;75.93811091743179;78.64769581111254;2.70585909673714;3.424962350027685;6.573143549597015;10.54844632462861;5.387878069355833;2.110344203709675;glnE;glutamate-ammonia-ligase adenylyltransferase;COG1391;Glutamine synthetase adenylyltransferase;GlnE1;HELO_RS16235;O;glnE; glutamate-ammonia-ligase adenylyltransferase;2.7.7.42,2.7.7.89;glnE;glutamate-ammonia-ligase adenylyltransferase;0.8474693248260579;0.08374051832713203;-0.049934218348227866;0.4348268426913027;-0.4126424821347552
HELO_3977;100.63577595989665;83.34026291752394;57.25545905312331;71.66323694564954;47.31781787847126;49.63216595874719;4.530501251811561;3.4401317083458283;6.535225243262971;8.886880612579802;6.466839445732973;8.642100814880687;dgkA;diacylglycerol kinase;COG0818;Diacylglycerol kinase;DgkA;HELO_RS16240;I;dgkA; diacylglycerol kinase;2.7.1.107;dgkA;diacylglycerol kinase;0.26911489841932035;0.20233904779008594;-0.06749890025826577;1.0052822157877896;0.7361673173684693
HELO_3978;94.70127724384929;85.94648473105458;78.47188953232812;92.2882336348597;64.56943643039533;78.68776980803813;2.743874282705977;5.420403483541902;1.4579347002194842;2.735632821649954;2.9919273387966507;8.335949236849043;HELO_3978;peptidase S13 family protein;COG2027;D-alanyl-D-alanine carboxypeptidase;DacB;HELO_RS16245;M;;dgkA;3.4.16.4,3.4.21.-;HELO_3978;peptidase S13 family protein;0.13841047909196558;-0.003913675054098675;-0.2813348266207045;0.2641798577024588;0.1257693786104932
HELO_3979;57.539732878636336;47.13312954567139;25.289940923268954;23.673011309486995;24.844805025920277;25.96671445089862;3.831901053351698;2.8631043885642935;0.6085276940537238;0.5741114713372321;6.4160896899676265;3.3800611589895344;HELO_3979;SMR family transport protein;COG2076;Multidrug transporter EmrE and related cation transporters;EmrE;HELO_RS16250;V;;;;HELO_3979;SMR family transport protein;0.2823859343583113;-0.0366688583035355;-0.06130543976483782;1.1182364042818476;0.8358504699235363
HELO_3980;18.32807878437944;24.58341294464383;28.08167508851551;23.887960111250408;26.451787662107716;23.598529908395438;1.6340934631974664;2.8297359690065207;1.4469706506192648;1.0809677335497514;0.427556183154617;2.5306516256092824;HELO_3980;BTP domain protein;COG4125;Uncharacterized membrane protein;;HELO_RS16255;S;;;;HELO_3980;BTP domain protein;-0.4045104987485306;0.24153827230249902;0.1583280028892773;-0.34787385734418574;0.05663664140434488
HELO_3981;24.521867571138312;16.976893154655304;47.38026670842296;37.24589294905142;37.80108698958381;46.026013936680876;0.5538346378198581;0.4539412060700034;8.288605179804032;2.737341038248981;5.7997687433864415;4.066531761222161;HELO_3981;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS16260;K;;;;HELO_3981;LysR family transcription regulator;0.5055901931295734;0.04095967225866204;-0.27736198107157417;-0.8817251476469714;-1.3873153407765448
HELO_3982;74.40997188097556;82.77181191844129;89.38776153019899;97.03021782835195;81.65876653352721;78.88394267220905;8.020218083424863;1.704960644180757;2.6144926450196673;10.180643515837122;4.2557838242276365;4.518993940326382;HELO_3982;probable S-adenosylmethionine-dependent methyltransferase;COG0220;tRNA G46 N7-methylase TrmB;TrmB;HELO_RS16265;J;;;2.1.1.33;HELO_3982;probable S-adenosylmethionine-dependent methyltransferase;-0.15170956649644385;0.17822190672694482;0.049262296656131355;-0.08315022704010211;0.06855933945634174
HELO_3983;347.5737039116047;292.3215580379183;417.84079542610743;392.654895614997;349.58819472364206;413.3666980222368;29.940809440317075;2.8466551117112133;8.108422127331824;10.409483928258208;10.096847709814265;16.252097666210567;fabY;3-oxoacyl-(acyl-carrier-protein) synthase FabY;COG0304;3-oxoacyl-(acyl-carrier-protein) synthase;FabB;HELO_RS16270;IQ;fabY; 3-oxoacyl-(acyl-carrier-protein) synthase FabY;2.3.1.180;fabY;3-oxoacyl-(acyl-carrier-protein) synthase FabY;0.24898063026186712;0.015493908126435585;-0.24113064325471534;-0.24944432268348216;-0.4984249529453493
HELO_3984;174.36632298987084;140.8072911433719;164.33843574583284;180.58947288218383;161.3679986588463;163.2284962871528;9.967711431377626;5.65937783310509;7.404233400393925;13.544944516459687;10.870440946293558;6.013747152350403;coaD;phosphopantetheine adenylyltransferase;COG0669;Phosphopantetheine adenylyltransferase;CoaD;HELO_RS16275;H;coaD; phosphopantetheine adenylyltransferase;2.7.7.3;coaD;phosphopantetheine adenylyltransferase;0.30644001012491273;0.009717663099191753;-0.016437161933843036;0.09466724236659285;-0.21177276775831988
HELO_3985;225.94668136460155;266.74337807546596;161.37547573637366;133.68994327689538;125.00469881492342;155.22146241377376;1.6411429590435047;5.639413165852821;19.815098386975674;7.94673467286433;6.547865011003844;20.965930313950466;HELO_3985;ferredoxin;COG1143;Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I);NuoI;HELO_RS16280;C;;coaD;;HELO_3985;ferredoxin;-0.23849750223134247;0.055741081473644094;-0.310115137123006;0.5387607208471445;0.777258223078487
HELO_3986;31.575629783545313;32.853383317173225;22.379999123782685;21.020220792976815;21.212390772901674;21.710613641611797;1.8257056696780858;1.1550310926826426;0.841424786606982;1.5231275795260502;2.27972454135212;3.6535555374541198;HELO_3986;MATE family transport protein;COG0534;Na+-driven multidrug efflux pump, DinF/NorM/MATE family;NorM;HELO_RS16285;V;;;;HELO_3986;MATE family transport protein;-0.05550695373875758;0.04190818755711412;-0.032002006274179706;0.5204263823930413;0.5759333361317989
HELO_3987;140.77828463190522;71.08248979777623;158.38459430723822;137.97204623347042;305.2011379504726;165.80061080511422;6.485290184058171;3.650149576995766;11.68193575682432;10.063516762893657;29.53526871861169;10.826774955086835;HELO_3987;AtoE family transport protein;COG2031;Short chain fatty acids transporter;AtoE;HELO_RS16290;I;;;;HELO_3987;AtoE family transport protein;0.9759158309748406;-0.06561238279404069;0.8763550726272298;-0.23448799162070166;-1.2104038225955422
HELO_3988;113.4322273504235;88.94967612083104;143.11560540313127;131.0285918359014;179.0707663516097;125.63543042114094;0.9252328139748714;1.9258405899385007;17.13430377483549;24.930190828298375;8.873307405873419;11.197539883022493;HELO_3988;thioesterase domain protein;COG1607;Acyl-CoA hydrolase;YciA;HELO_RS16295;I;;;;HELO_3988;thioesterase domain protein;0.34730342112251567;0.18654546208286327;0.507882882880887;-0.14618768951593974;-0.4934911106384554
HELO_3989;70.59699353240457;41.74460493853029;120.30615302561625;92.46182576164146;145.38573537050522;130.81572432175287;1.0849992334431233;1.4793307711850991;15.286401161215151;2.8333980337037925;13.658232251884497;3.6027817263575432;HELO_3989;histidine triad domain protein;COG0537;Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family;HinT;HELO_RS16305;FR;;;;HELO_3989;histidine triad domain protein;0.744156667775643;-0.11986974966885722;0.15125249638236848;-0.880551567069678;-1.624708234845321
HELO_3990;75.80230540857002;36.07801060617831;58.43188719317834;82.00590798397201;87.91315439035903;63.516036437429584;4.040231482793713;5.3463085274449265;4.94920143289931;7.726524984741368;3.715348709418836;5.676796572183947;HELO_3990;uncharacterized protein;;;;;;;;;HELO_3990;uncharacterized protein;1.0505857783259938;-0.11842061595671183;0.46273906773151996;0.2514918088059659;-0.7990939695200279
HELO_3991;47.13875886511559;26.409587974534787;37.58891373021533;46.93314181641546;48.155656790483626;35.905855382030005;4.478432670868188;1.5192804429210909;2.95240584747083;6.582151311298935;4.796292155819768;4.447242122655366;HELO_3991;uncharacterized protein;;;;;;;;;HELO_3991;uncharacterized protein;0.8125183045909798;0.06433670439655703;0.4135077217244918;0.3833492175939064;-0.42916908699707346
HELO_3992;1966.9985258369713;1161.9046395911582;1740.8782728904073;3323.856622801286;1751.1707852211182;1786.2257941605458;20.391550580582802;171.35504577359816;37.21522914047011;415.98909260709166;30.059916795222726;25.19626410355134;HELO_3992;Dps domain protein;COG0783;DNA-binding ferritin-like protein (oxidative damage protectant);Dps;HELO_RS16320;VP;;;;HELO_3992;Dps domain protein;0.7589963420985661;-0.03707810472616657;-0.028578510587273342;0.1390072272022156;-0.6199891148963506
HELO_3993;157.51853864890268;118.40948937067417;152.72281194570127;130.07835435558442;158.87176464813356;155.34907890481716;1.0200696562972769;3.3262839101729167;10.33374031702376;1.136671353936662;9.580205392105139;12.095618485343019;rmuC;DNA recombination protein RmuC;COG1322;DNA anti-recombination protein (rearrangement mutator) RmuC;RmuC;HELO_RS16325;L;rmuC; DNA recombination protein RmuC;;rmuC;DNA recombination protein RmuC;0.4087340816514624;-0.024439447993817254;0.032144443362502884;0.019880852582267572;-0.38885322906919484
HELO_3994;273.2914380668592;196.5306081417224;358.98161028845493;313.0547725579728;396.05668443250374;391.6975917558432;3.0829884568971213;4.500600092043526;35.11285605631121;11.675817002570474;25.33332568174727;33.24277762987628;pepD;non-specific dipeptidase%2C cytosolic;COG2195;Di- or tripeptidase;PepD2;HELO_RS16330;E;pepD; non-specific dipeptidase, cytosolic;3.4.13.-;pepD;non-specific dipeptidase%2C cytosolic;0.47363336769191644;-0.12549554245104666;0.01592623286102146;-0.5177091610548743;-0.9913425287467907
HELO_3995;62.26392611993771;25.553097643808012;43.917760620506904;56.4264188140637;48.25049974290848;44.3684970609537;1.2734282000030837;1.434834138691505;4.977830342181748;1.6885371499608157;1.9060323321349963;0.7740284712043709;tmcA;tRNA(Met) cytidine acetyltransferase TmcA;COG1444;tRNA(Met) C34 N-acetyltransferase TmcA;TmcA;HELO_RS16335;J;tmcA; tRNA(Met) cytidine acetyltransferase TmcA;2.3.1.193;tmcA;tRNA(Met) cytidine acetyltransferase TmcA;1.2525029179444953;-0.014404863961618553;0.1184474958278372;0.4796922236052188;-0.7728106943392765
HELO_3996;85.73708293893326;28.33744076664658;278.0807728398445;477.59043765981147;486.33622074568166;298.8469487373522;5.498311940652837;1.4972942716362512;12.607381003289737;46.89795426937227;25.707738091351185;29.485957168680283;HELO_3996;TRAP transporter substrate-binding protein;COG4663;TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component;FcbT1;HELO_RS16340;Q;;tmcA;;HELO_3996;TRAP transporter substrate-binding protein;1.56390590073838;-0.10354355799709225;0.7006911613709281;-1.7895054621679956;-3.3534113629063755
HELO_3997;45.854048224498705;17.995053326475627;56.48522217745472;96.18677397055323;90.84264904133323;64.06282783919856;2.4775879876514133;3.6398687121534254;4.624193301669501;8.222884014758236;13.583434239843731;1.31711871708025;HELO_3997;TRAP transporter small transmembrane protein;COG4665;TRAP-type mannitol/chloroaromatic compound transport system, small permease component;FcbT2;HELO_RS16345;Q;;;;HELO_3997;TRAP transporter small transmembrane protein;1.3025499409780013;-0.1786424002117224;0.49733072674483125;-0.47365982470525303;-1.7762097656832543
HELO_3998;28.75127327415866;9.217153766196452;37.15337559611328;48.916664323312126;61.08882719807187;38.56952694383265;0.9078850527388551;0.21875778909850907;3.0227918309643447;5.38824708789904;4.538777663025082;1.1501948235588733;HELO_3998;TRAP transporter large transmembrane protein;COG4664;TRAP-type mannitol/chloroaromatic compound transport system, large permease component;FcbT3;HELO_RS16350;Q;;;;HELO_3998;TRAP transporter large transmembrane protein;1.5419580583359052;-0.05257911365362666;0.6499438628419147;-0.4114384047104602;-1.9533964630463654
HELO_3999;57.75590441232108;30.37126179070533;52.79802125225103;54.23984240539982;45.72139537686337;49.48716296612552;4.082924002576412;1.596545530031625;2.2766276492495297;4.132749997299603;0.8393658883123544;2.6638474709433884;futB;ABC-type transport system permease protein (probable substrate iron);COG1178;ABC-type Fe3+ transport system, permease component;FbpB;HELO_RS16355;P;futB; ABC-type transport system permease protein (probable substrate iron);;futB;ABC-type transport system permease protein (probable substrate iron);0.9052902788441681;0.09163649986332523;-0.11183324779721016;0.21881722610539533;-0.6864730527387728
HELO_4000;151.10650650245847;77.03603747964549;200.449269541774;217.7052980934001;170.8745640611138;189.07604105562473;2.4573181887294315;0.19614032083008054;19.873582795073776;8.634733675036383;15.456643375097876;6.086355761132844;futC;ABC-type transport system ATP-binding protein (probable substrate iron);COG3842;ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component;PotA;HELO_RS16360;E;futC; ABC-type transport system ATP-binding protein (probable substrate iron);7.2.2.7;futC;ABC-type transport system ATP-binding protein (probable substrate iron);0.9628694394220663;0.08383988145720878;-0.14522063849469014;-0.3214948257502295;-1.2843642651722957
HELO_4001;339.2146548729086;75.33613094812621;388.71362116750265;172.33064358901163;328.88524708420283;525.0782586354738;24.88148909790679;0.7546991487656391;182.03125987593097;18.354854020547844;11.80991122678511;435.4966377776419;futA;ABC-type transport system periplasmic substrate-binding protein (probable substrate iron);COG1840;ABC-type Fe3+ transport system, periplasmic component;AfuA;HELO_RS16365;P;futA; ABC-type transport system periplasmic substrate-binding protein (probable substrate iron);;futA;ABC-type transport system periplasmic substrate-binding protein (probable substrate iron);2.1560073155957458;-0.43286307161078774;-0.6733131686288054;-0.6288321417290632;-2.784839457324809
HELO_4002;66.20980311731076;83.14122813619146;109.22461118743809;92.21780388796732;100.89399130615062;104.24123307793356;3.5033292761642594;4.648816919915399;6.232857980438248;2.3071422423451424;8.32892823098192;4.840859017806551;polA;DNA polymerase 1;COG0749;DNA polymerase I, 3'-5' exonuclease and polymerase domains;PolA;HELO_RS16370;L;polA; DNA polymerase 1;2.7.7.7;polA;DNA polymerase 1;-0.3241411984168776;0.06674633060536905;-0.0466310791005764;-0.6469564745941563;-0.3228152761772787
HELO_4003;241.55368788460547;92.52512867213647;283.75867687078215;243.12199069937188;308.54704657999423;276.23648782579795;28.596459099768616;16.954912162703135;8.38491517917894;14.236479310148503;45.056212488978275;18.221041301732416;HELO_4003;DUF2782 domain protein;;;;;;;;;HELO_4003;DUF2782 domain protein;1.37487816426576;0.03862265603575388;0.15904154757295075;-0.19281303185318777;-1.5676911961189477
HELO_4004;194.36992897332377;161.02080905277595;171.20383117732467;161.06071360816372;155.50309423866108;180.8467108205979;10.014091051240287;6.403635408169757;6.734896412807373;3.853038045347996;7.712410006625204;9.129718585805366;thrB;homoserine kinase;COG2334;Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist;SrkA;HELO_RS16380;T;thrB; homoserine kinase;2.7.1.39;thrB;homoserine kinase;0.27002931033549515;-0.07860559101072617;-0.2165316499577301;0.1034855960143819;-0.16654371432111326
HELO_4005;145.00288936047147;105.51493220201108;124.7487382534688;123.45963781679075;127.72878016899068;128.69814379098293;6.117801533263888;1.1201781105018997;3.57472839323196;4.141065051075231;6.791782576369174;3.937730952721671;speA;arginine decarboxylase;COG1166;Arginine decarboxylase (spermidine biosynthesis);SpeA;HELO_RS16385;E;speA; arginine decarboxylase;4.1.1.19;speA;arginine decarboxylase;0.45494122562427375;-0.044613907940237674;-0.010823196189440054;0.17083908773120005;-0.2841021378930737
HELO_4006;362.9843950213849;180.9751304436247;258.75886411646087;293.5222600748881;362.9816052370091;264.60684417710627;25.173998363038816;7.327994733234861;11.244342328283903;5.188320240669469;23.614995082615007;10.26758108479684;gcd;quinoprotein glucose dehydrogenase;COG4993;Glucose dehydrogenase, PQQ-dependent;Gcd;HELO_RS16390;G;gcd; quinoprotein glucose dehydrogenase;1.1.5.2;gcd;quinoprotein glucose dehydrogenase;1.0001353010072513;-0.032119341559829095;0.45457321925875505;0.45458427694024905;-0.5455510240670023
HELO_4007;135.38303301845266;117.63647334028043;90.7218944976285;79.8014717078434;76.08829276970589;66.06204334713858;3.316872093638056;16.579833105799594;11.255831414842977;19.90013744057735;10.801083462434578;4.779706772141003;HELO_4007;YcgM family protein;COG0179;2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway);YcgM;HELO_RS16395;Q;;gcd;;HELO_4007;YcgM family protein;0.20111655728562994;0.45176971180534586;0.20101533583509212;1.0240958272858567;0.8229792700002267
HELO_4008;17.59446230636911;127.20110992783289;18.625832877439652;44.57321908472133;18.82669843259546;16.464788189984727;1.4436965560536918;10.657465748988507;2.251180456363872;8.439244063591266;0.7340284892981849;0.36974891460841863;ectD;ectoine hydroxylase;COG5285;Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family;PhyH;HELO_RS16400;Q;ectD; ectoine hydroxylase;1.14.11.55;ectD;ectoine hydroxylase;-2.785463817001589;0.1683047340508761;0.1829953120514327;0.09042388425360315;2.875887701255192
HELO_4009;88.39811697859845;86.7446009371651;115.08950846477427;70.88056193243095;75.63036675949483;108.79148396213617;1.9583457726207143;5.2710804569692655;2.1510975475766543;9.252959543879824;7.6487436561506374;6.210157976142819;HELO_4009;YodA family protein;COG3443;Periplasmic Zn/Cd-binding protein ZinT;ZinT;HELO_RS16405;P;;ectD;;HELO_4009;YodA family protein;0.02693408691625887;0.08047143996778061;-0.5187780395417523;-0.2964498063451986;-0.32338389326145744
HELO_4010;5.391385109292917;2.9560117274621995;5.916323862933326;5.274130843218906;3.6825653497477338;6.6478645686892435;0.3084520823205243;0.3547719556687658;1.0809125133861266;1.490374071369295;0.21342635125973117;0.490663859237944;znuA;ABC-type transport system periplasmic substrate-binding protein (probable substrate zinc);COG4531;ABC-type Zn2+ transport system, periplasmic component/surface adhesin ZnuA;ZnuA;HELO_RS16410;P;znuA; ABC-type transport system periplasmic substrate-binding protein (probable substrate zinc);;znuA;ABC-type transport system periplasmic substrate-binding protein (probable substrate zinc);0.6920819158483058;-0.145051549726273;-0.7077578469298769;-0.2589283569772687;-0.9510102728255745
HELO_4011;3.1852451030963973;2.889160558192248;4.458887483137929;3.407748618945613;3.5020093201692624;4.041512928624091;0.4945981368767623;0.5371562007592702;0.7865521763055885;0.8542743735344055;0.7158696852281539;0.8201165392901971;znuC;ABC-type transport system ATP-binding protein (probable substrate zinc);COG1121;ABC-type Mn2+/Zn2+ transport system, ATPase component;ZnuC;HELO_RS16415;P;znuC; ABC-type transport system ATP-binding protein (probable substrate zinc);7.2.2.20;znuC;ABC-type transport system ATP-binding protein (probable substrate zinc);0.10585331917702279;0.11475021794979945;-0.16328769956960398;-0.26854462837584014;-0.37439794755286293
HELO_4012;7.697115772307896;5.5219542620989905;6.25021390904561;5.743539187257568;4.7660842265454315;6.128694714371474;1.2969126802786928;0.7922321654016208;2.362670577191363;1.2986103768805022;0.961281487671309;0.7388869505279421;znuB;ABC-type transport system permease protein (probable substrate zinc);COG1108;ABC-type Mn2+/Zn2+ transport system, permease component;ZnuB;HELO_RS16420;P;znuB; ABC-type transport system permease protein (probable substrate zinc);;znuB;ABC-type transport system permease protein (probable substrate zinc);0.4152327151650188;0.024385621766219057;-0.30604602824018023;0.2868990997794256;-0.12833361538559318
HELO_4013;482.7495463003989;329.1263282509344;433.04758396160287;423.31716314526125;465.5747153999603;442.9743349246958;21.960462558926178;14.101994430318763;25.378983653643253;6.768503919084369;13.105071219955963;29.73678740851181;hisF;imidazoleglycerol-phosphate synthase subunit HisF;COG0107;Imidazole glycerol phosphate synthase subunit HisF;HisF;HELO_RS16425;E;hisF; imidazoleglycerol-phosphate synthase subunit HisF;4.3.2.10;hisF;imidazoleglycerol-phosphate synthase subunit HisF;0.5512421071475551;-0.0326230685447193;0.07163184666496747;0.1237840278829232;-0.42745807926463186
HELO_4014;414.4696866938257;291.75393233401786;305.9764983364155;294.9907806931048;304.3356031471419;314.701938937531;14.089580466480378;20.544728463640947;18.96861635924938;10.871799543485047;6.628292047606037;9.769584944987516;hisA;1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;COG0106;Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase;HisA;HELO_RS16430;E;hisA; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;5.3.1.16;hisA;1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;0.5050546701425471;-0.04043491199756666;-0.04816729884222326;0.3961800983536179;-0.10887457178892923
HELO_4015;420.9405253792617;273.4894811933161;251.18787395877212;241.2057418989091;248.03821670079128;267.1770260874338;11.348418930140127;13.735924471554508;12.202217018861612;15.98735759819713;11.543703423152474;10.649680471295204;hisH;imidazoleglycerol-phosphate synthase subunit HisH;COG0118;Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH;HisH;HELO_RS16435;E;hisH; imidazoleglycerol-phosphate synthase subunit HisH;4.3.2.10;hisH;imidazoleglycerol-phosphate synthase subunit HisH;0.6202887939318078;-0.08868674352312311;-0.1068185000416495;0.6538540069773386;0.03356521304553084
HELO_4016;372.16503676823936;232.90248706306838;332.6069457772274;320.23965140864993;283.4653494877313;345.8064658552087;10.272514434728732;8.82000956134155;14.763675195496667;3.0871226332998383;13.739780475686679;1.4546134039240877;hisB;imidazoleglycerol-phosphate dehydratase;COG0131;Imidazoleglycerol phosphate dehydratase HisB;HisB2;HELO_RS16440;E;hisB; imidazoleglycerol-phosphate dehydratase;4.2.1.19;hisB;imidazoleglycerol-phosphate dehydratase;0.673906619200678;-0.05598147004329057;-0.2858778667719566;0.1056830246148337;-0.5682235945858443
HELO_4017;121.55996277228617;35.15678314955574;76.88935604897485;64.85177817966273;73.65395199135342;73.09004766349524;9.266121398542763;6.89686473263502;7.532378671132212;9.072865713947289;6.783310741606277;8.270871163343484;HELO_4017;DUF3749 family protein;;;;;;;;;HELO_4017;DUF3749 family protein;1.7611495314177272;0.07214642879808952;0.010938873188819365;0.7261360972246598;-1.0350134341930675
HELO_4018;212.63845227712736;85.86354524558662;142.66256539907204;151.03463719980672;149.47252549080815;142.72285694553776;5.770720916496194;1.4002280654961632;4.8195620507593135;4.872929572910642;10.66297369847489;5.206781948840629;HELO_4018;AsmA family protein;COG2982;Uncharacterized conserved protein AsmA involved in outer membrane biogenesis;AsmA;HELO_RS16450;M;;;;HELO_4018;AsmA family protein;1.2983485964381245;-0.0006053356197410764;0.06621057306802314;0.5718818187907955;-0.726466777647329
HELO_4019;87.81394647123132;46.88127357158729;63.40644976969338;60.298212209847236;57.092190417722634;57.57432038960784;6.042229688928469;1.5378396740964226;1.3484152774009628;3.6855787925356664;0.9132382522766676;2.7976508994931857;mutY;A/G-specific adenine glycosylase;COG1194;Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs;MutY;HELO_RS16455;L;mutY; A/G-specific adenine glycosylase;3.2.2.31;mutY;A/G-specific adenine glycosylase;0.8913247146845453;0.13693685919971443;-0.011924081286869281;0.6005179307755313;-0.29080678390901404
HELO_4020;85.26423865821401;110.04692012787103;67.99198977911912;63.88321461266499;81.00017006122239;72.05726104121719;6.681630873529853;10.89108666291348;5.362990193593132;7.307490721874019;8.96678096914483;6.516860680608645;HELO_4020;probable iron trafficking protein;COG2924;Fe-S cluster biosynthesis and repair protein YggX;YggX;HELO_RS16460;OP;;mutY;;HELO_4020;probable iron trafficking protein;-0.3643348696452682;-0.08259879777229706;0.16659923451188519;0.23973493847338467;0.6040698081186529
HELO_4021;51.50235464659892;120.12811534274601;26.095327697690365;26.330909510422448;22.69909627642269;21.66412684125916;5.5620483586718725;5.611634128202114;3.2955586212235124;3.430071611848038;1.601105425743012;6.045269689886799;HELO_4021;ParA domain protein;COG1192;ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ;ParA;HELO_RS16480;DN;;;;HELO_4021;ParA domain protein;-1.2060797394653617;0.2576335145573747;0.06442146453309494;1.211971545806068;2.4180512852714298
HELO_4022;3.5835535529832008;2.994353011057258;2.432924075572558;2.617111107160126;2.1765777968491196;2.7750315409829622;0.3295381013342615;0.2854096042255724;0.08265713022718586;0.20996120769371193;0.6575406336249393;0.3607905326217407;dnaB2;replicative DNA helicase;COG0305;Replicative DNA helicase;DnaB;HELO_RS16485;L;dnaB2; replicative DNA helicase;3.6.4.12;dnaB2;replicative DNA helicase;0.1985046893972282;-0.137050748217314;-0.24901534614265364;0.2799778312070509;0.08147314180982268
HELO_4023;2.3079815593507838;2.034616143445182;1.231533532250549;1.1190760425793564;1.044128945086351;1.7776315320360927;0.11786089911879277;0.7774340233775914;0.36747243631376025;0.7771636141349899;0.4066544317210295;0.41042981525097666;HELO_4023;uncharacterized protein;;;;;;;;;HELO_4023;uncharacterized protein;0.12443715435226976;-0.31581974516856537;-0.4423690252903849;0.2520959614440321;0.12765880709176236
HELO_4024;1.7739040526390044;1.8977010474818379;0.5016741604836175;0.8375653619912624;0.33816879385687343;0.8141052215159229;0.15101825609615568;0.018484377902244952;0.09589876128894402;0.17247846766107996;0.18663054040722052;0.4406834409785489;HELO_4024;uncharacterized protein;;;;;;;;;HELO_4024;uncharacterized protein;-0.06299087463432973;-0.2726863324913863;-0.43899803127993675;0.6126597494129786;0.6756506240473084
HELO_4025;1.6367784381968313;1.4397414851047305;0.4868131910163636;0.3290552474003318;0.4462038214452357;1.006622266048551;0.2952977682780516;0.3449076028370849;0.5028867868709865;0.4146062920056396;0.09684539605163887;0.2442781917453709;HELO_4025;uncharacterized protein;;;;;;;;;HELO_4025;uncharacterized protein;0.11204806230438025;-0.432545671072169;-0.4724981704892096;0.3940072862497914;0.2819592239454112
HELO_4026;3.2703676874322984;2.1825114088636313;1.6943934446615165;1.4783144810590276;1.2682817879547355;2.0521857463195805;0.2189214858254396;0.1286077160553184;0.42548159786081136;0.5402894652342948;0.554061736477055;0.2496087676597958;yfdR;YfdR family protein;COG1896;5'-deoxynucleotidase YfbR and related HD superfamily hydrolases;YfbR;HELO_RS16505;FR;yfdR; YfdR family protein;;yfdR;YfdR family protein;0.42419460820291444;-0.1798822291681499;-0.42824288569842817;0.4845175315241874;0.06032292332127298
HELO_4027;1.7259343239284128;1.9377957729504383;3.6247275719243053;2.2254690614664905;1.4679953641907488;2.0574032803053615;0.048315470676012634;0.4037284692276472;1.6613510465459178;0.8350988130621751;0.924634194555842;0.48042106388571004;HELO_4027;uncharacterized protein;;;;;;;;;HELO_4027;uncharacterized protein;-0.10798330376287013;0.5970615231189713;-0.30896717583626465;-0.16555605677230578;-0.05757275300943565
HELO_4028;5.838818025269091;4.963305593197411;5.06157832769713;5.069436258267076;4.894650209215403;5.298821373707914;0.9986410289208082;1.0065076316150594;0.6561357440083039;0.5241639808689295;0.653875328173648;0.5527238523469116;HELO_4028;DUF1528 domain protein;;;;;;;;;HELO_4028;DUF1528 domain protein;0.19763473063571002;-0.05538840400493328;-0.09567569319618441;0.11866510220212367;-0.07896962843358635
HELO_4029;4.189479411609012;2.8550932764882995;2.2506503936143853;2.243493278144766;1.4412153795646887;2.515508526999042;0.20581309372682322;0.3362807075473311;0.6670923675164407;0.5780152643009894;0.07057771819758443;0.18274606954837333;HELO_4029;DUF2786 domain protein;;;;;;;;;HELO_4029;DUF2786 domain protein;0.42882405277930524;-0.11300499080498527;-0.526133809320265;0.5618564264893298;0.13303237371002452
HELO_4030;2.956487402078134;1.8906361289607723;1.6801475161981003;1.3783173618375721;1.354722605686946;1.2310705266556932;0.5849221903944574;0.2842119861826884;0.8677407328655264;0.6753403795816436;0.3000568406147841;0.3340495703918567;HELO_4030;uncharacterized protein;;;;;;;;;HELO_4030;uncharacterized protein;0.45283314861172674;0.26457628975621694;0.07782099595637493;0.8264840440001737;0.373650895388447
HELO_4031;3.700382980365095;2.816706266676338;4.825664590172762;4.411399186570304;3.603176224087278;4.945234583802727;0.11222623689348189;0.10184447611772465;0.1289298102433322;0.4219454201456683;0.5326436259810398;0.22139960125267494;HELO_4031;ParB domain protein;;;;;;;;;HELO_4031;ParB domain protein;0.30045014910888623;-0.029311094764419288;-0.3691040616328829;-0.3389554258911538;-0.63940557500004
HELO_4032;6.643099070271827;3.877179809476471;4.593057970098794;4.057482573702951;3.185192132801928;4.713777390955754;1.4102160009272016;0.7548290832008582;1.178191015646028;0.757337413413566;0.9600717558267751;0.8564600040544819;HELO_4032;DUF2857 domain protein;;;;;;;;;HELO_4032;DUF2857 domain protein;0.6481105688394502;-0.030807546467571;-0.44915097470476173;0.41971290086746293;-0.22839766797198724
HELO_4033;5.369689560658771;2.511094804235063;4.331545988459808;5.419525878735212;4.263391344768604;4.955044807977887;0.20893381599284852;0.26475368929661824;0.7393114433389043;0.3078615073700077;0.7648502669286408;0.5600264196595065;HELO_4033;uncharacterized protein;;;;;;;;;HELO_4033;uncharacterized protein;0.859302110184522;-0.1595584315569436;-0.1781196971251391;0.09711069811057405;-0.7621914120739479
HELO_4034;20.662818237832074;9.197169311676648;13.881362593127143;14.721214452441837;13.569943461038074;11.734099082747399;1.0593744137681627;0.5611647512422749;1.6066997184471505;0.43516610417178936;3.648888651879581;3.2081609450239417;HELO_4034;uncharacterized protein;;;;;;;;;HELO_4034;uncharacterized protein;1.0870522213455898;0.2248097361956738;0.19429838416240752;0.7665240486225566;-0.32052817272303313
HELO_4035;13.72292262850437;9.1649763573498;7.091143713638236;7.585924777837273;7.739758813454457;6.8530404900751885;1.1673679063799023;1.2457187429208045;1.353618029118984;1.2411849467396885;0.9245889356489712;1.0506707263478785;HELO_4035;DUF3158 family protein;;;;;;;;;HELO_4035;DUF3158 family protein;0.5344572277358859;0.04309231182859907;0.15434213135700592;0.9067408466361542;0.3722836189002683
HELO_4036;22.016949593741966;11.798270672985884;8.551992545663751;10.507632635546031;9.779379455819317;7.806444873783707;2.3155377819594767;0.649405619046604;3.094478372061932;1.2275348431924753;0.4382225030766459;2.2243925776353266;HELO_4036;uncharacterized protein;;;;;;;;;HELO_4036;uncharacterized protein;0.8467477639914578;0.11724198421674314;0.2916424962067903;1.386065016024086;0.5393172520326281
HELO_4037;11.847648969465524;1.604117756512158;6.845857573131433;8.211147220900733;6.798733067152079;6.600801995221076;1.4472279304681526;0.5008009224284581;0.8146632815579751;0.40002573166363425;1.814774253362511;1.3222442098544407;HELO_4037;homolog to single-strand DNA-binding protein;COG0629;Single-stranded DNA-binding protein;Ssb;HELO_RS16580;L;;;;HELO_4037;homolog to single-strand DNA-binding protein;2.3026377875754482;0.04577949431341111;0.03708811998920325;0.7572808233765813;-1.545356964198867
HELO_4038;18.390846458905603;4.494352763213603;8.319704285198242;12.901033016521241;8.639498339735757;10.043365022241261;1.292530630929284;0.567456893014387;1.707066140457455;0.5329554898636892;2.712684398943108;1.1370201638355149;HELO_4038;DUF304 domain protein;;;;;;;;;HELO_4038;DUF304 domain protein;1.8193543357757669;-0.24482375859921746;-0.1961498699505433;0.8121959395496559;-1.007158396226111
HELO_4039;28.870901817377995;12.865610159244987;42.46340180707053;48.88523325722142;27.815471577622475;33.62191919850219;2.306707289816806;1.9991986959754298;3.475112642146845;1.4169781292228447;5.930531916945287;10.180968118840237;HELO_4039;uncharacterized protein;;;;;;;;;HELO_4039;uncharacterized protein;1.1072296900978196;0.32811539633879505;-0.26484206965990964;-0.21294490591757498;-1.3201745960153946
HELO_4040;27.024078199560222;3.402932215464977;12.361930260735328;14.491687814865813;13.06233162335126;11.734296891749663;1.3269377943635012;0.22429370011331215;1.301084139666059;0.10028854791511528;1.0628035582004893;0.9010613386562611;topB2;DNA topoisomerase 3;COG0551;DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains;YrdD;HELO_RS16605;L;topB2; DNA topoisomerase 3;5.6.2.1;topB2;DNA topoisomerase 3;2.6701303802031955;0.06940912898024676;0.14311651697677874;1.1379476138031182;-1.5321827664000773
HELO_4041;34.04293784189169;5.748815742185683;20.433771645459604;21.744366359451377;19.142208092067747;19.314680264140147;1.450287567523489;0.6421632388589505;3.041195230782698;2.622613654041576;2.015853451246786;2.211135388850403;HELO_4041;uncharacterized protein;;;;;;;;;HELO_4041;uncharacterized protein;2.3764174584865825;0.07736308172514317;-0.012300810312207311;0.786601071106273;-1.5898163873803095
HELO_4042;1.4022841130316814;0.5352739423984999;1.51445780000367;1.0898097480248297;1.3377915266498792;1.2026461412334133;0.0800582720181345;0.17013749514139423;0.27422476200804635;0.34558397430979987;0.4835537436646072;0.4303717663583012;tfc2;secretion cluster MPF-G protein Tfc2;;;;;;;;;tfc2;secretion cluster MPF-G protein Tfc2;0.6459106837070658;0.19100959865859624;0.08590854049145524;0.12516904331163192;-0.5207416403954339
HELO_4043;1.1276633893060934;0.5477801931905405;0.8317212582962531;0.5812917388480808;1.256646568031904;0.8169093302002294;0.23986898501778794;0.29164412761796454;0.4177098355328841;0.1329595055151172;0.5012720717136336;0.3911080963674292;HELO_4043;uncharacterized protein;;;;;;;;;HELO_4043;uncharacterized protein;0.4590693220028247;0.011713552294337015;0.3126940577906865;0.22778349870687897;-0.2312858232959457
HELO_4044;1.1186689867351831;0.47518774485263965;0.7701277188125498;0.4295318008170817;0.4585585080005754;0.5868897363071265;0.04463300557520253;0.10302159130688791;0.31585059744131216;0.20725282685901766;0.17294324555990587;0.5911410664990544;HELO_4044;uncharacterized protein;;;;;;;;;HELO_4044;uncharacterized protein;0.5222596280869888;0.15765157064125712;-0.12165862815237938;0.4169563165936233;-0.10530331149336547
HELO_4045;0.8489336205181847;0.5003117582969115;0.709394843533223;0.46856614414929615;0.8392209264265901;0.7123246149911364;0.12628261546990063;0.17314668299185415;0.07614926007259304;0.0423670779741504;0.30420984579901517;0.5315722436188801;tfc3;secretion cluster MPF-G protein Tfc3;;;;;;;;;tfc3;secretion cluster MPF-G protein Tfc3;0.3014311130978118;-0.0024705519183684244;0.10313855860085608;0.11073720329679637;-0.19069390980101542
HELO_4046;1.6300858478559281;1.0536354076526164;0.7821517374027832;0.5595281553248305;0.8808739943669416;0.798303099618713;0.18798008616455425;0.38074704129422676;0.4826027707580334;0.16263375734213184;0.5531049701092702;0.3604394551709306;tfc4;secretion cluster MPF-G protein Tfc4;;;;;;;;;tfc4;secretion cluster MPF-G protein Tfc4;0.3569298154740579;-0.013016026895300126;0.06476699735305125;0.5484736867779457;0.19154387130388784
HELO_4047;1.0295734684348374;0.4733603939904754;0.6270596804288698;0.6503408079384656;0.5729864370835205;1.1476854031121533;0.183802873728637;0.35594053018024313;0.34941917094959785;0.15116792051143693;0.33454268158914197;0.669523826593586;tfc5;secretion cluster MPF-G protein Tfc5;;;;;;;;;tfc5;secretion cluster MPF-G protein Tfc5;0.462066198454005;-0.400515510261682;-0.4492764488750357;-0.08160611515916338;-0.5436723136131684
HELO_4048;2.2631148161950354;1.2117410936702038;0.7995811251730416;0.48743794444706107;0.8234390004798001;0.8579157904879088;0.47845483712174874;0.12011031613064999;0.5296812072934609;0.21005042510798017;0.39203655155950323;0.4012649260854221;HELO_4048;uncharacterized protein;;;;;;;;;HELO_4048;uncharacterized protein;0.5610672374665004;-0.046023972988443185;-0.027023175462380533;0.8125646376410817;0.2514974001745812
HELO_4049;1.386341941621417;0.49949514761400104;0.8228816686113917;0.8580497552558931;0.8787689055039302;1.1307919142228628;0.16012531480322825;0.14145356207093898;0.2342061571332493;0.17204838101030234;0.3786274257524391;0.14893588125989374;HELO_4049;uncharacterized protein;;;;;;;;;HELO_4049;uncharacterized protein;0.6703239296068348;-0.22516879874628093;-0.1816020897514674;0.16341107185506054;-0.5069128577517743
HELO_4050;1.713314110784858;0.7735458773944565;0.9692172940817292;1.3839919108613559;0.7881676530496199;0.7383103830642251;0.16705400737185483;0.09536059765771039;0.0682557129106142;0.14602102974888345;0.2157828160844711;0.184254551700967;tfc6;secretion cluster MPF-G coupling protein;COG3505;Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase;VirD4;HELO_RS16655;U;tfc6; secretion cluster MPF-G coupling protein;;tfc6;secretion cluster MPF-G coupling protein;0.6134194231642783;0.17993661001272643;0.040796300691648524;0.6423703682133093;0.02895094504903095
HELO_4051;2.9252768227163712;1.0823194206478373;1.0903739013191027;1.2100697145078436;0.6575458015481773;0.9340548848640955;0.22955258962049552;0.41648993691017333;0.16699797075021813;0.2000376548757413;0.1587497320450759;0.3443606165549128;tfc7;secretion cluster MPF-G protein Tfc7;;;;;;;;;tfc7;secretion cluster MPF-G protein Tfc7;0.9146030108510532;0.11213228119963281;-0.2225800007362846;1.0211656645429834;0.10656265369193019
HELO_4052;0.6141412206854591;0.6486374320131163;1.0719223356694627;0.5961609990942239;0.6489896850959297;0.6418920230845419;0.11598121665795486;0.11643806743018881;0.9065286345451811;0.01445793540455485;0.197034652815876;0.4050308530099992;tfc8;secretion cluster MPF-G protein Tfc8;;;;;;;;;tfc8;secretion cluster MPF-G protein Tfc8;-0.03050735142418215;0.33561067252994525;0.006223121078799965;-0.024592448199977524;0.005914903224204626
HELO_4053;1.09684191760657;0.40178735578676766;0.4395046017100564;0.30005959676438154;0.1945845386672871;0.599425079856456;0.4928814826754445;0.2061578083797285;0.761244300322141;0.2985262991162003;0.33703030733909206;0.8038565041409408;tfc9;secretion cluster MPF-G protein Tfc9;;;;;;;;;tfc9;secretion cluster MPF-G protein Tfc9;0.5809505834967761;-0.15198101461112945;-0.4210444610064387;0.390664684307093;-0.19028589918968308
HELO_4054;5.36030857763659;0.8674671716529151;2.5233141160073775;2.588667508751491;2.8801217998005253;2.898831679041692;0.6096599535992719;0.3629408395935748;0.781496738929968;0.7835633594050286;1.004754616607842;1.4837946452218576;tfc10;secretion cluster MPF-G protein Tfc10;;;;;;;;;tfc10;secretion cluster MPF-G protein Tfc10;1.768013879213782;-0.14610876985863186;-0.006939931475574035;0.7060548893768868;-1.0619589898368953
HELO_4055;5.6286505597626375;1.4686953193853831;1.544726390384328;0.8226452777437906;1.42174962344237;1.0313151325299683;0.24236167955925722;0.29733753714210814;0.6468565196163277;0.5045576569060987;0.6099476104970617;0.3122653278060881;tfc11;secretion cluster MPF-G protein Tfc11;;;;;;;;;tfc11;secretion cluster MPF-G protein Tfc11;1.4249664074095791;0.3250964730517558;0.2536356446910497;1.7063011281645493;0.2813347207549701
HELO_4056;1.939616968458786;0.7087057771458848;0.7458580691378703;0.9131274351176177;0.6810589434965837;0.682894575456706;0.13595391652450073;0.18009020234541545;0.3675788866742579;0.2781810386961416;0.35261840327966393;0.4236159087896501;tfc12;secretion cluster MPF-G protein Tfc12;;;;;;;;;tfc12;secretion cluster MPF-G protein Tfc12;0.7827241843543074;0.052991476541918936;-0.0015744910705193238;0.8046833822137995;0.021959197859492186
HELO_4057;2.848726032048113;1.5391010851123532;1.7098519579357863;1.6240617728290705;1.6852356091800906;1.8713073255286339;0.32613643476599197;0.1460586251733938;0.3203676236063655;0.35017595976404436;0.5159058862765585;0.473822571626781;tfc13;secretion cluster MPF-G protein Tfc13;;;;;;;;;tfc13;secretion cluster MPF-G protein Tfc13;0.6000631461048116;-0.08349371745222056;-0.09665907585835898;0.4226732226748926;-0.177389923429919
HELO_4058;2.332298425311104;0.9835497009728059;1.2438293580957878;1.4979483238292461;1.3131503899353911;1.335996952202459;0.19932731627199674;0.10562098918286633;0.16513252576477025;0.2690440110881307;0.3172760345378894;0.5746929342078689;tfc14;secretion cluster MPF-G protein Tfc14;;;;;;;;;tfc14;secretion cluster MPF-G protein Tfc14;0.7484330606768919;-0.058075427912872124;-0.014179325791078945;0.512479215696287;-0.2359538449806049
HELO_4059;6.859452994889156;2.73832732776989;3.340258046991425;3.5807840796067123;2.331765905272869;3.0488741421458214;0.8133653465088944;0.8715184928796705;0.3337132982960166;0.6752843459076506;0.5896088198976092;0.7623149421074779;tfc15;secretion cluster MPF-G protein Tfc15;;;;;;;;;tfc15;secretion cluster MPF-G protein Tfc15;1.0720360098302573;0.10026002160493253;-0.28123375962567554;0.9569081087215134;-0.11512790110874382
HELO_4060;4.549462500897618;1.849575618153364;3.4676096507754353;3.2449685106322743;3.500677466513567;3.1778710163589925;0.1027830403387596;0.18893574788413847;0.03198092734654763;0.5102940469536893;0.278131215667026;0.2327659827772063;tfc16;secretion cluster MPF-G VirB4-type ATPase protein;COG3451;Type IV secretory pathway, VirB4 component;VirB4;HELO_RS16705;U;tfc16; secretion cluster MPF-G VirB4-type ATPase protein;;tfc16;secretion cluster MPF-G VirB4-type ATPase protein;0.9616009670023753;0.09673518579694207;0.10737422742302849;0.4095800917748065;-0.5520208752275688
HELO_4061;9.624562314584544;3.5581197544784344;4.741094798913285;5.6282108252770096;4.815302838256213;4.791879009348823;0.872071980814248;0.4556585924667653;0.3862289622498559;0.5537620575744225;1.0155515783333444;0.865212743797956;HELO_4061;uncharacterized protein;;;;;;;;;HELO_4061;uncharacterized protein;1.2208926759365473;-0.012705587182372913;0.005822858316831159;0.8753000393871138;-0.3455926365494335
HELO_4062;11.750781633079912;2.8654772437037868;4.286548854435282;5.30515482066079;5.727778473573232;5.576856194115017;0.8100073782254908;0.43751935058465347;0.9132615576815751;0.496753727181973;0.8973657284700054;0.3223414315140688;HELO_4062;uncharacterized protein;;;;;;;;;HELO_4062;uncharacterized protein;1.7218672383269853;-0.31507191074798024;0.03273207712136017;0.9551156575898321;-0.7667515807371532
HELO_4063;5.063294312744109;2.130887239009289;1.3646239024386724;2.216301910969919;1.9480089457440863;1.317121326984262;0.717857087891016;0.23314937383447676;0.8402670359851885;0.5024562359576766;0.7750169354808221;0.4247868648357792;HELO_4063;DUF2726 family protein;;;;;;;;;HELO_4063;DUF2726 family protein;0.9535303028712381;0.0292771513885568;0.34740731504645916;1.387768265403375;0.43423796253213687
HELO_4064;1.986866177909251;0.9369162041718159;1.4286988583407485;2.048309789409913;1.7209064931834617;1.7716550750792657;0.11052838591048328;0.0774230777258856;0.4060243687463513;0.4504029532287372;0.3774496980524558;0.4005782989706937;HELO_4064;DsbC family protein;COG1651;Protein thiol-disulfide isomerase DsbC;DsbG;HELO_RS16735;O;;;5.3.4.1;HELO_4064;DsbC family protein;0.6248710605901612;-0.1905641122037871;-0.026660351474238064;0.1078848721143495;-0.5169861884758117
HELO_4065;2.6176035662892296;0.9481873642249085;0.7094135944935603;1.4003598307609313;1.3045180071230558;1.1024183329665662;0.14914057978794878;0.7132774084518475;0.4666785072218123;0.15340049134568878;0.431826044612481;0.3855190876567365;HELO_4065;uncharacterized protein;;;;;;;;;HELO_4065;uncharacterized protein;0.8929018861411117;-0.29854826014940383;0.1324152796541036;0.7829845583884871;-0.10991732775262453
HELO_4066;19.149006749977385;5.263531429448583;2.9042751095427843;3.301018879386073;2.6876070142060677;2.7687225993912192;1.8368717685924505;0.3745775778240501;0.8847827438107777;0.36141368525929946;0.687032365393609;0.5586681774982523;HELO_4066;uncharacterized protein;;;;;;;;;HELO_4066;uncharacterized protein;1.6856605277772378;0.05097910617206147;-0.03139069097307434;2.4185612095083524;0.7329006817311146
HELO_4067;9.860986398757575;2.7231218338367853;2.798876094561759;3.3143315929413943;2.20221380544122;3.079484598736014;0.658518728163611;0.4690876810971794;1.0226546804407222;0.3157289919918681;0.8382688609506106;0.4654025276607956;tfc24;secretion cluster MPF-G protein Tfc24;;;;;;;;;tfc24;secretion cluster MPF-G protein Tfc24;1.5445704029776595;-0.10281423657152078;-0.3493172569623688;1.412696336162885;-0.13187406681477443
HELO_4068;5.271912075320206;1.6315383106833021;2.3141761184131804;2.5644917102836966;2.9628463423738878;2.3575075493147017;0.1503039133152004;0.371563435419966;0.33159942558428945;0.2888596512765482;0.15698654775915008;0.38398900883926873;tfc23;secretion cluster MPF-G protein Tfc23;;;;;;;;;tfc23;secretion cluster MPF-G protein Tfc23;1.2529989365935503;-0.018740372780613246;0.23914638498539564;0.9015146912033856;-0.35148424539016476
HELO_4069;12.794822071519988;3.3676176024714954;5.725089383838242;6.861823603201032;7.259299814194814;5.7177824405728925;0.6010943323644518;0.2781099887631097;0.4358843170020582;0.6603426640149146;0.8815103261118621;0.5759121777238214;tfc22;secretion cluster MPF-G protein Tfc22;;;;;;;;;tfc22;secretion cluster MPF-G protein Tfc22;1.659208393846618;0.0015683690194858713;0.2980344079348103;1.0380698697364452;-0.6211385241101728
HELO_4070;4.411618482335261;1.4025015949166295;0.6620916867685634;0.7365752814161213;0.42435238517718316;0.41750419366669966;1.0018114856708364;0.2651708525865887;0.3958983396321359;0.6582140994176385;0.09407004810350807;0.10924386283663029;tfc18;secretion cluster MPF-G protein Tfc18;;;;;;;;;tfc18;secretion cluster MPF-G protein Tfc18;1.171522744540558;0.22964696502125959;0.00695311025106482;1.9327071299152867;0.7611843853747287
HELO_4071;10.728633713928668;3.8520805861974883;5.80575547383486;5.953975212454353;5.387094537552705;4.819145820386605;0.034376188248608455;0.1278176398231857;1.119984022604426;1.4937732745173957;0.7822705806809318;0.40961460621600637;tfc19;secretion cluster MPF-G protein Tfc19;;;;;;;;;tfc19;secretion cluster MPF-G protein Tfc19;1.2733595445582884;0.22594791853913998;0.13435240584463948;1.0111556576968814;-0.26220388686140694
HELO_4072;240.78001577504133;79.42663187319575;294.11581073439487;291.9566015040861;225.95373637056116;229.39582923095085;28.700332465540026;17.651833275466185;47.68644288043443;60.8316918082336;52.61845219264832;33.52559566959366;HELO_4072;uncharacterized protein;;;;;;;;;HELO_4072;uncharacterized protein;1.587949795294346;0.3571666143111756;-0.021716360692752623;0.06958040371548524;-1.5183693915788607
HELO_4073;242.41888879350893;158.6127517394806;178.85537455196587;220.3165902134518;187.38814260596791;161.95319963771055;17.65587839299866;9.900907287810401;20.088138048434555;25.347296341184325;22.39832821724287;13.999671626539056;HELO_4073;YhgA domain protein;COG5464;Recombination-promoting DNA endonuclease RpnC/YadD;RpnC;HELO_RS16790;L;;;;HELO_4073;YhgA domain protein;0.6088652069216431;0.14237959151352886;0.20925048258237045;0.5789834423656393;-0.029881764556003887
HELO_4074;93.10898440844186;69.69812063786193;122.06730622182472;106.5581734210132;93.56016723264577;101.88459608228918;13.407049628201522;20.84150262308938;18.86500408359761;19.17512063540212;15.302897116307369;7.147903818922096;hupB2;HU-type DNA-binding protein HupB;COG0776;Bacterial nucleoid DNA-binding protein IHF-alpha;HimA;HELO_RS16795;L;hupB2; HU-type DNA-binding protein HupB;;hupB2;HU-type DNA-binding protein HupB;0.4126605964169512;0.25842055207365533;-0.1217225055118627;-0.1286226315597805;-0.5412832279767317
HELO_4076;248.24191709800786;216.17973665049726;394.7144975906255;444.4077412956851;177.96572222070154;351.5393161751572;11.30883930885727;7.663982503093987;20.32082797173165;10.473709206177375;22.01051715856202;48.91204889098952;HELO_4076;DUF2235 family protein;;;;;;;;;HELO_4076;DUF2235 family protein;0.19865721607430764;0.1666757616741208;-0.9781008691464255;-0.5002374410292338;-0.6988946571035415
HELO_4077;61.057500118230585;61.3765740067376;251.59824272867874;309.76173394997244;124.18150554128788;228.75336868594437;4.274500757708306;1.930978496837689;18.857024341461795;7.172649868505841;33.41339840160657;34.07246215243661;vgr3;T6SS-related Vgr family protein;COG3501;Uncharacterized conserved protein VgrG, implicated in type VI secretion and phage assembly;VgrG;HELO_RS16820;UXR;vgr3; T6SS-related Vgr family protein;;vgr3;T6SS-related Vgr family protein;-0.007398734289912667;0.1367585879149873;-0.876064582128337;-1.888408528115817;-1.8810097938259043
HELO_4078;68.52871581832339;119.50635308598942;25.29367626808389;30.484203697929868;9.84851300668454;21.247214501085512;4.4964260406332075;15.988726896638871;2.637307559713038;2.4598125295103763;2.3294507375068307;3.46115379121548;hcp2;T6SS-related Hcp family protein;COG3157;Type VI protein secretion system component Hcp (secreted cytotoxin);Hcp;HELO_RS16825;U;hcp2; T6SS-related Hcp family protein;;hcp2;T6SS-related Hcp family protein;-0.7934283586400062;0.24109115504691214;-1.0361274047360207;1.6439842310911503;2.4374125897311565
HELO_4079;29.783552560265637;8.985046127573936;23.498541760966017;32.12779377450456;20.588637105412033;23.549508018969775;3.3366283211890138;0.4776864142757019;5.965667640487155;2.0304773120610298;4.510969997604752;0.7162520063132188;HELO_4079;uncharacterized protein;;;;;;;;;HELO_4079;uncharacterized protein;1.6243187371972674;-0.0029982351783104377;-0.18542194406386425;0.326465622064533;-1.2978531151327344
HELO_4080;60.00813867055297;51.13801101643835;55.36870160852833;82.57118883643864;58.969759090185136;55.72871155961909;4.110797647238485;4.9741933224543535;6.874206544583155;4.793694505212695;4.841858098579377;1.8437963031765543;HELO_4080;integrase family protein;COG4974;Site-specific recombinase XerD;XerD;HELO_RS16835;L;;;;HELO_4080;integrase family protein;0.2266661680396478;-0.009184760478962772;0.08015607980134476;0.10492261796749691;-0.12174355007215087
HELO_4081;33.06831478645649;19.818914892726266;19.057466958678862;24.80063241568499;27.995492031873226;14.821233860108814;3.205039844019523;2.069455924325408;2.1663969131863885;1.6581045179068346;14.044966868010889;6.210969838541336;HELO_4081;DUF3577 family protein;;;;;;;;;HELO_4081;DUF3577 family protein;0.7105357096886138;0.3422773041343876;0.87396650341018;1.1065684687311355;0.39603275904252166
HELO_4082;103.21515722391034;54.10677947116588;77.59979992553822;63.64014201842971;106.84796960197365;74.71477481498546;7.914298207296181;5.544705930693911;2.858098320824651;4.17313146468307;8.226590582700409;6.529405369662838;HELO_4082;uncharacterized protein;;;;;;;;;HELO_4082;uncharacterized protein;0.9192633994890418;0.053950788106136294;0.5103522587403484;0.4609183636776537;-0.4583450358113881
HELO_4083;80.61437382729645;65.56241280980844;59.33848568597487;44.985195944040164;82.25642451175288;62.340485472394995;4.279968178785442;3.5180918366703775;1.755995218708816;2.9587800690170645;1.4176216182631933;7.952330843679381;HELO_4083;beta-lactamase domain protein;;;;;;;;;HELO_4083;beta-lactamase domain protein;0.2941155298847713;-0.07004943528317131;0.3944336776304196;0.3656953353963255;0.07157980551155418
HELO_4084;74.60067347981328;56.5379607649763;74.95613180216098;73.16701885949432;107.59885377381211;82.47747530998335;1.3308805837701205;4.137080316906717;3.49210733206276;1.2444031363345027;7.250201378927207;7.234121745560927;HELO_4084;TetR family transcription regulator;COG1309;DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA;AcrR;HELO_RS16880;K;;;;HELO_4084;TetR family transcription regulator;0.39388499596265003;-0.13622053272686863;0.3795500025887959;-0.142987881751508;-0.536872877714158
HELO_4085;127.80946810912438;69.52868060211739;176.0480604771677;163.99602779220592;231.1287906736733;177.28059164680738;5.618276052108229;2.1367941852035246;1.0807287703306565;9.96792705907009;24.65288503439825;9.672420023569414;HELO_4085;amidase domain protein;COG0154;Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase;GatA;HELO_RS16885;J;;;3.5.1.4;HELO_4085;amidase domain protein;0.8689566860879996;-0.010008614431714413;0.3807758157904244;-0.46891101153423076;-1.3378676976222303
HELO_4086;52.478227803321424;18.72872699497733;44.726889310711215;45.76285042470126;20.81973149949354;39.478650844404946;2.6159919542419425;1.6831149482438463;4.61052518965552;6.37093397797921;2.1446043909842505;6.240883536752397;HELO_4086;PuuR family transcription regulator;COG1917;Cupin domain protein related to quercetin dioxygenase;QdoI;HELO_RS16890;R;;;;HELO_4086;PuuR family transcription regulator;1.4386537887310915;0.17588157371034363;-0.8915278568984109;0.4017904515157129;-1.0368633372153786
HELO_4087;2.2395684877795468;9.296098935016666;3.2012804174632414;1.1974617511954222;8.027209663916022;4.024783675236486;0.45990292327533894;1.054556438702342;0.44719955959420105;0.2908078256629369;3.9980501929193175;1.0506264479825236;HELO_4087;aldolase domain protein;COG0235;5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation);AraD;HELO_RS16895;GE;;;4.1.2.17;HELO_4087;aldolase domain protein;-1.668224258282511;-0.2582324046104696;0.8452186281280931;-0.6332598291883242;1.0349644290941868
HELO_4088;15.319401896408237;11.299283701332586;6.482724334809798;3.886691562845856;10.135645554964386;5.084407559134166;1.2502877910068317;0.8849687659573516;0.35922728290156186;0.6864004839487001;0.9331169563211209;0.759895518647986;HELO_4088;DapA domain protein;COG0329;4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase;DapA;HELO_RS16900;ME;;;4.3.3.7;HELO_4088;DapA domain protein;0.40801388691061735;0.2984468328331018;0.8719964972031242;1.4233994845491988;1.0153855976385815
HELO_4089;21.149072385838497;4.896774037069494;14.326102150661322;26.553467445849325;25.67462459005038;15.42454088722007;2.668113442321257;0.9962200292620871;2.489537180876112;3.443244150474099;11.89124459692258;3.2152706364295467;HELO_4089;uncharacterized protein;;;;;;;;;HELO_4089;uncharacterized protein;1.9092484626474282;-0.09986221705309761;0.6996149235054512;0.43139323559146003;-1.4778552270559682
HELO_4090;49.87140226208019;13.093738105744144;34.09592152209947;36.902517296827234;25.394197134441242;27.607976278859965;0.6602539886122947;1.639816834848431;2.949396608080651;6.307934622601962;3.4148487435888817;2.206188783926351;HELO_4090;uncharacterized protein;;;;;;;;;HELO_4090;uncharacterized protein;1.8518005515852183;0.29488594008510294;-0.11619666297889975;0.8304374170254913;-1.021363134559727
HELO_4091;6.6228584484920345;1.484120562330105;2.7070344389289875;3.5362024771524196;2.692726809288924;2.626821826263973;0.5212477996298244;0.16508819862297755;0.5777088967316042;0.41356361760629273;0.23207744041160755;0.6609300505479286;ardC;antirestriction protein ArdC;COG4227;Antirestriction protein ArdC;ArdC;HELO_RS16940;L;ardC; antirestriction protein ArdC;;ardC;antirestriction protein ArdC;1.617596892585166;0.031559645858417085;0.02598066260227916;1.07162621423232;-0.545970678352846
HELO_4092;13.099969268602777;21.407711207307926;10.917874192126922;9.636020778026982;9.161579316981356;10.173785101633461;0.4979613104832492;1.3974655774249811;0.6980308010502081;0.5976485063131988;0.16713851894484535;1.8035456891594315;umuC2;DNA polymerase 5 complex protein UmuC;COG0389;Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair;DinP;HELO_RS16955;L;umuC2; DNA polymerase 5 complex protein UmuC;;umuC2;DNA polymerase 5 complex protein UmuC;-0.6683032768342936;0.09300894399066939;-0.13699333541338854;0.33557403899410776;1.0038773158284013
HELO_4093;18.38579900422607;22.606709010913686;21.51129386265342;16.027142761432803;19.218309174666455;20.431134541595124;0.8258515862496346;2.452001924312747;1.7809630484925656;1.9209028124985879;1.6662312532534673;1.4975904931087762;umuD2;DNA polymerase 5 associated protein UmuD;COG1974;SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase);LexA;HELO_RS16960;KT;umuD2; DNA polymerase 5 associated protein UmuD;3.4.21.-;umuD2;DNA polymerase 5 associated protein UmuD;-0.284196732457767;0.07094075295569713;-0.08404587481280323;-0.14470802841677077;0.13948870404099623
HELO_4094;2.5772980557523337;0.6860165378062408;1.2998280208869275;1.194337077460936;1.0670008291507278;1.19013048310649;0.14300784067761638;0.20022881744403498;0.21116934571945037;0.4618901859593338;0.4308980364620752;0.20416096031825876;HELO_4094;relaxase domain protein;;;;;;;;;HELO_4094;relaxase domain protein;1.0852516393249103;0.07050915678809133;-0.08347785746905534;0.7078535018365646;-0.37739813748834583
HELO_4095;16.112302294136157;2.658234421138275;7.963101392496455;8.481223772332969;7.47060148564405;7.399621398740208;1.2871506265508177;0.43074579264721535;0.7898946170026108;1.5365527900646525;0.8206728826614457;1.0738805378762637;HELO_4095;integrase family protein;COG4974;Site-specific recombinase XerD;XerD;HELO_RS16970;L;;;;HELO_4095;integrase family protein;2.225814441854795;0.09367371492883247;0.012140115082367675;1.0266376665010326;-1.1991767753537628
HELO_4096;25.64424316830797;53.56443967082032;41.91884867818913;28.422632193121903;44.73586583403107;50.87295538016818;1.993438090686814;4.743226488037193;5.173829995720767;1.2184159363437779;0.7877494224190003;3.550011156344932;HELO_4096;LldP family transport protein;;;;;;;;;HELO_4096;LldP family transport protein;-1.034137181129342;-0.2733711918046229;-0.1816566040764549;-0.9611587135062392;0.0729784676231029
HELO_4097;9.608694400410414;18.630982576945787;10.27779575095652;5.278200912225053;9.687262164826015;11.073702337945363;1.8675325658929423;0.8303366227329575;1.4918745675974459;0.9295116506371602;1.2268180714617123;2.26243064786462;HELO_4097;transport protein (homolog to lactate permease);;;;;;;;;HELO_4097;transport protein (homolog to lactate permease);-0.8878852685093457;-0.09838301880781453;-0.17597582435027626;-0.18662102246797962;0.7012642460413661
HELO_4098;30.168230233587753;11.027466152919262;28.085310918913308;31.02106128917319;18.51008670054199;23.550740045571306;1.6630130959735812;0.17031311734367657;2.8103652680615183;2.228393756820327;2.2793600567742027;4.493403373565226;HELO_4098;probable oxidoreductase;COG1249;Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase;Lpd;HELO_RS16985;C;;;;HELO_4098;probable oxidoreductase;1.373743500009652;0.24452421341318598;-0.3315463239641865;0.34430972638353463;-1.0294337736261174
HELO_4099;2.5786022545518237;1.2543645973599271;5.614002701139654;12.652486341372244;3.412691724950441;4.675874004972127;0.17754044177305203;0.03968774249637872;1.2061144212061836;0.2282448782978483;1.3026706913589938;2.698345281366463;HELO_4099;acyl carrier protein / thioesterase / cytochrome P450 domain protein;COG3319;Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase;EntF2;HELO_RS16995;Q;;;;HELO_4099;acyl carrier protein / thioesterase / cytochrome P450 domain protein;0.6666753428466008;0.22068107041469087;-0.36318360158859253;-0.6654463606681909;-1.3321217035147916
HELO_4100;34.52037980269743;14.016756128770107;37.3365762070893;33.561130376189425;28.52034939441323;37.83177325179048;1.9450413524065144;0.5008936692271062;7.3796664668671985;0.5873666793314127;3.2954691155052664;1.7396484599022146;HELO_4100;uncharacterized protein;;;;;;;;;HELO_4100;uncharacterized protein;1.2420738076515954;-0.018516091954577263;-0.3955277925522438;-0.12859058154821668;-1.370664389199812
HELO_4101;151.28205330144633;84.79628709226513;146.8470565960935;218.43251446114832;170.03799851576196;134.9688830472162;6.191298486829197;3.6087673011098245;13.500947213708947;17.271620865553157;17.581033807356423;4.015975918255194;yjaG;DUF416 family protein YjaG;COG3068;Uncharacterized conserved protein YjaG, DUF416 family;YjaG;HELO_RS17010;S;yjaG; DUF416 family protein YjaG;;yjaG;DUF416 family protein YjaG;0.8277588074569593;0.12082899847863171;0.3310403524116179;0.1634694043217424;-0.6642894031352169
HELO_4102;165.76292569317013;102.23676536686277;81.11650733340815;106.1962885764841;76.17168050717568;87.97659874990796;15.058859993217068;9.227939187710692;14.811814721863522;17.428087267875274;17.008912959879527;17.395238043959253;HELO_4102;HTH domain protein;COG3695;Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain;Atl1;HELO_RS17015;K;;yjaG;;HELO_4102;HTH domain protein;0.6918417436919997;-0.11575368409833242;-0.20535442808376914;0.9063007324377121;0.21445898874571245
HELO_4103;31.733596976401824;24.442760585437515;23.56578103264034;20.40974977698195;25.15676687573854;26.063809072449445;1.089507739065985;0.8786050380099093;3.260388263976779;1.3562886097717823;3.265346207109376;1.0410346234618522;HELO_4103;GATase domain protein;COG0518;GMP synthase, glutamine amidotransferase domain;GuaA1;HELO_RS17020;F;;;;HELO_4103;GATase domain protein;0.3635169294953391;-0.13971479630211725;-0.049180677880403145;0.27440723915255294;-0.08910969034278615
HELO_4104;168.36804943582396;115.34890621245086;200.95559335023643;214.34969885631588;183.75626221531027;186.5939205141813;4.050667073822125;4.872987170133355;4.700230687145099;8.481553229096045;4.827769671913342;2.1002704148479143;selU;tRNA 2-selenouridine synthase;COG2603;tRNA 2-selenouridine synthase SelU, contains rhodanese domain;SelU;HELO_RS17025;J;selU; tRNA 2-selenouridine synthase;2.9.1.3;selU;tRNA 2-selenouridine synthase;0.5417040939006004;0.10642502919562702;-0.021989809613934597;-0.1474513321585551;-0.6891554260591555
HELO_4105;238.1350222478856;166.49554511002995;297.20370592613125;259.79606368932286;233.93276077142443;280.2160993780447;1.6194357776178736;11.560604285289719;5.311456991860927;1.3462762185964456;3.185050345432961;5.143640802018959;selD;selenide%2C water dikinase;COG0709;Selenophosphate synthase;SelD;HELO_RS17030;E;selD; selenide, water dikinase;2.7.9.3;selD;selenide%2C water dikinase;0.5137027091592001;0.08461899700745867;-0.2594312823111933;-0.2338537560303653;-0.7475564651895654
HELO_4106;131.66967557351612;117.386673330117;169.7685825294829;167.4787242671811;144.7985188397209;162.33712108322192;0.6456573610506975;8.554426605264894;9.564312917424342;4.4651041787460946;14.673116274456337;10.031761428049332;radA;DNA repair protein RadA;COG1066;DNA repair protein RadA/Sms, contains AAA+ ATPase domain;Sms;HELO_RS17035;L;radA; DNA repair protein RadA;;radA;DNA repair protein RadA;0.16433196292886532;0.06418987218559469;-0.16387664118902467;-0.300014054365195;-0.46434601729406033
HELO_4107;2207.432744680771;759.6820349977176;1868.1402631883975;1458.608366215537;1474.621240052196;1533.159094730139;132.57907072979484;65.51595781302532;84.63726807311112;235.67905955436564;367.0607207808563;229.02792467220175;HELO_4107;NlpE domain protein;;;;;;;;;HELO_4107;NlpE domain protein;1.5376574589192948;0.2849267348604059;-0.0561256399533292;0.5255747970412301;-1.0120826618780647
HELO_4108;63.6691753432737;18.690181437140648;34.73050510493664;36.361118900430284;34.238398643457565;35.91874883619908;5.740539338464245;0.9177585484457408;0.6409828605333094;1.6659600449097232;1.6373168315616866;2.5845672499532535;HELO_4108;AEC family transport protein;COG0679;Predicted permease, AEC (auxin efflux carrier) family;YfdV;HELO_RS17045;R;;;;HELO_4108;AEC family transport protein;1.7156018082004394;-0.047197352617392774;-0.06720529674891651;0.808724551989024;-0.9068772562114154
HELO_4109;114.17082183522261;59.01619263196971;160.84993986714719;105.30974106872641;129.135531936387;163.1133340870831;5.702684511328591;4.282030420939432;18.467951532041436;5.584243019756521;12.572369549434152;7.463413551988229;hisC;histidinol-phosphate aminotransferase;COG0079;Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase;HisC;HELO_RS17050;E;hisC; histidinol-phosphate aminotransferase;2.6.1.9;hisC;histidinol-phosphate aminotransferase;0.9403515570273484;-0.02003563198339986;-0.33467753520870946;-0.5109172006899163;-1.4512687577172647
HELO_4110;42.99026120435332;28.00096910547498;17.738523767242143;8.794598907912247;12.421032817068168;17.811635295961086;6.197272926746549;4.525664688057635;2.229319772049623;1.3278687521977643;0.20982576946564055;1.5309070225597163;yaeR;glyoxalase domain protein YaeR;COG0346;Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family;GloA;HELO_RS17055;Q;yaeR; glyoxalase domain protein YaeR;;yaeR;glyoxalase domain protein YaeR;0.6010830570791734;-0.005617966785400164;-0.48712956926414774;1.2255588998434996;0.6244758427643262
HELO_4111;386.30172002756507;357.8450747527597;366.7944928779869;312.74871365707145;332.5896235820486;343.32837714479666;9.804700349943074;13.042529083101014;26.023393894601416;6.283255971802293;8.781729991310957;18.108318018152342;tyrS;tyrosine--tRNA ligase;COG0162;Tyrosyl-tRNA synthetase;TyrS;HELO_RS17085;J;tyrS; tyrosine--tRNA ligase;6.1.1.1;tyrS;tyrosine--tRNA ligase;0.11009678900611775;0.09511479523212607;-0.045710668712970914;0.1696728257892186;0.05957603678310086
HELO_4112;101.77063660786779;41.605757682188816;91.25775820338065;97.10002834602965;111.14715797488181;91.66932361937154;5.5229746117493255;3.358951360583149;5.0032821806986005;4.5301138408131765;9.305081707710931;7.542261964180345;anmK;anhydro-N-acetylmuramic acid kinase;COG2377;1,6-Anhydro-N-acetylmuramate kinase;AnmK;HELO_RS17090;M;anmK; anhydro-N-acetylmuramic acid kinase;2.7.1.170;anmK;anhydro-N-acetylmuramic acid kinase;1.2703078073496759;-0.0064216053065253575;0.27522931340928114;0.14926437306216211;-1.1210434342875137
HELO_4113;24.78660733288437;13.115832518081;31.417718329952805;51.423461256096;34.04078730026004;27.411320471923958;0.7479708173777816;1.2397377514237806;3.800027092177862;1.6254342659741443;4.340191540084979;1.9868166725155165;pilT;twitching motility protein PilT;COG2805;Type IV pilus assembly protein PilT, pilus retraction ATPase;PilT;HELO_RS17095;NW;pilT; twitching motility protein PilT;;pilT;twitching motility protein PilT;0.8693077565194232;0.19031666743905618;0.30256930476253796;-0.13984391064810175;-1.009151667167525
HELO_4114;89.60085264383893;86.93705213937113;73.77009991226623;76.15103311072963;75.93872712948105;71.49670844230728;2.0489906945553247;4.2795648555468;3.0571806788092406;5.729110431914068;4.435068264278311;7.867695077634048;HELO_4114;UPF0001 family protein;COG0325;Pyridoxal 5'-phosphate homeostasis protein YggS, UPF0001 family;YggS;HELO_RS17100;H;;pilT;;HELO_4114;UPF0001 family protein;0.04305345675831429;0.044545966721217134;0.08579446781836886;0.3216091333881579;0.2785556766298436
HELO_4115;261.87514552949284;159.24328296713603;319.5623491388794;274.01133551530984;365.1013267564024;353.17248069235876;13.8187509060416;3.0291175026087407;16.984002044910973;10.407377082421723;10.856093879629375;19.151015625233732;proC;pyrroline-5-carboxylate reductase;COG0345;Pyrroline-5-carboxylate reductase;ProC;HELO_RS17105;E;proC; pyrroline-5-carboxylate reductase;1.5.1.2;proC;pyrroline-5-carboxylate reductase;0.7141138600166776;-0.14384713135829408;0.047790883390627314;-0.4300743749654057;-1.1441882349820833
HELO_4116;148.6267502119463;91.2291722693342;149.29275925928698;122.36707946386436;176.5758082951902;160.5171744521212;9.836044011364066;6.294839250422883;15.143067482321563;14.515433366024483;7.161949086097147;3.9167825122109092;HELO_4116;YggT family protein;COG0762;Cytochrome b6 maturation protein CCB3/Ycf19 and related maturases, YggT family;Ycf19;HELO_RS17110;O;;proC;;HELO_4116;YggT family protein;0.6980730674981608;-0.1039120724159055;0.1367474744453263;-0.11031945505570473;-0.8083925225538655
HELO_4117;206.88168561639236;139.749750677856;192.5751262242471;161.21347124808264;186.94611556998484;206.14936291189392;15.756769893602664;1.8923608110159267;3.076550524857083;1.3134637623249203;10.56009475423785;7.358618732687889;metX;homoserine O-acetyltransferase subunit MetX;COG2021;Homoserine O-acetyltransferase;MET2;HELO_RS17115;E;metX; homoserine O-acetyltransferase subunit MetX;2.3.1.31,2.3.1.46;metX;homoserine O-acetyltransferase subunit MetX;0.5626302955744595;-0.09777780042429729;-0.14035228493636343;0.005091278998696325;-0.5575390165757632
HELO_4118;157.11281673145487;125.30378520779668;167.01985480298706;171.34868171027668;167.4445258553618;186.70824620535822;19.173647651351626;7.238039614148836;3.7818900769738764;9.08911488856196;11.01302444511864;3.05155699281925;metW;homoserine O-succinyltransferase subunit MetW;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS17120;H;metW; homoserine O-succinyltransferase subunit MetW;;metW;homoserine O-succinyltransferase subunit MetW;0.3240564422570946;-0.15986030508961857;-0.15621848633062552;-0.24753771228529065;-0.5715941545423853
HELO_4119;191.18122097424816;142.80185490219586;201.2223365242523;202.44572556527;185.32636359365165;173.72379194619143;10.395399952726338;8.701442016065744;10.657514077100702;20.527478871387462;14.380624755343336;6.215279176326483;sfsA;regulator protein SfsA;COG1489;DNA-binding protein, stimulates sugar fermentation;SfsA;HELO_RS17125;TG;sfsA; regulator protein SfsA;;sfsA;regulator protein SfsA;0.41838508452823575;0.2108662874981917;0.09275574595929115;0.13739129794470628;-0.28099378658352947
HELO_4120;216.64590361712115;136.78783226097948;271.07024532611354;273.6342226431788;273.5037556352329;280.0150091646363;8.481584009289474;3.6357409721579534;16.91927868357279;6.085806397415532;16.133646721991315;2.4165956966637885;aspC;aspartate aminotransferase;COG0436;Aspartate/methionine/tyrosine aminotransferase;AspB;HELO_RS17130;E;aspC; aspartate aminotransferase;;aspC;aspartate aminotransferase;0.6595343745026838;-0.04666800123039749;-0.03382129997035577;-0.36866432067321764;-1.0281986951759015
HELO_4121;1060.187572829257;401.35686615990727;677.5991125792615;533.6138058121867;443.90346797001257;566.4923867088132;47.82196845702288;10.56985945314709;69.8102170304686;96.57198607551626;32.16439766849051;42.65056881162033;dksA;RNA polymerase-binding transcription factor DksA;COG1734;RNA polymerase-binding transcription factor DksA;DksA;HELO_RS17135;K;dksA; RNA polymerase-binding transcription factor DksA;;dksA;RNA polymerase-binding transcription factor DksA;1.3991321285245082;0.25795850559108224;-0.35110869361621333;0.9030067429922521;-0.49612538553225605
HELO_4122;521.875077042915;231.35823214912602;171.32031487622103;148.61055012653185;192.91811367727075;187.9136441450364;19.39475530247641;3.5646737163973032;8.210096002735424;5.300118610793074;12.997738798315066;9.783619256237909;gluQ;glutamyl-Q tRNA(Asp) synthetase;COG0008;Glutamyl- or glutaminyl-tRNA synthetase;GlnS;HELO_RS17140;J;gluQ; glutamyl-Q tRNA(Asp) synthetase;6.1.1.-;gluQ;glutamyl-Q tRNA(Asp) synthetase;1.1701155468850741;-0.13263411185265106;0.03772066724551326;1.468739402395717;0.29862385551064285
HELO_4123;46.95729915019931;36.45831679023926;1.5103724064394803;1.8624753313425957;2.2795643564022208;2.508039885669408;3.719500864652787;1.9942330550901104;0.29619070217754356;0.6703129627640787;1.3059731364109273;0.5342741972287426;HELO_4123;uncharacterized protein;;;;;;;;;HELO_4123;uncharacterized protein;0.3564643388684807;-0.4827637513502696;-0.09716096501059757;3.773013355497456;3.4165490166289754
HELO_4124;66.36023394616582;35.38466408356522;38.45029176952375;36.27378761138945;43.713324076072944;37.44246313643975;4.239463159209348;1.4272968276329028;2.6838939219105655;2.72445183573436;0.6524226947296143;1.7735673848859426;HELO_4124;PAS domain protein / sensor histidine kinase;COG4191;Signal transduction histidine kinase regulating C4-dicarboxylate transport system;;HELO_RS17150;T;;;;HELO_4124;PAS domain protein / sensor histidine kinase;0.888566657696833;0.03733519293229115;0.21800402530034368;0.8091963716384907;-0.07937028605834229
HELO_4125;74.75154215289182;43.160727935353776;49.77392382466228;50.93234548920663;59.84142869995076;52.426589179494556;1.3177780656357931;0.47633488923860295;4.9001138026492;4.987671441788794;1.2184470757421235;3.9261458128532936;HELO_4125;response regulator/sigma-54-interact/HTH domain transcription regulator;COG2204;DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains;AtoC;HELO_RS17155;T;;;;HELO_4125;response regulator/sigma-54-interact/HTH domain transcription regulator;0.7785113059596158;-0.07347016034016818;0.18749611469695004;0.5037173426887485;-0.27479396327086736
HELO_4126;292.8602783091646;292.288561718782;410.54678029166956;513.9214353543317;320.5169195855621;409.12800192072547;5.016773772488959;20.2681575397054;25.786986619772417;25.638970256931994;20.647313551124434;10.578982972011653;pcnB;poly(A) polymerase;COG0617;tRNA nucleotidyltransferase/poly(A) polymerase;PcnB;HELO_RS17160;J;pcnB; poly(A) polymerase;2.7.7.19;pcnB;poly(A) polymerase;0.0028095531973626464;0.004982181754659365;-0.35117958825927076;-0.48094388840091007;-0.4837534415982727
HELO_4127;233.5071134457891;239.9646472395319;198.813058065783;208.96262796388703;181.33260421382238;200.62398645132282;23.531024022740358;18.296946888267662;8.90033718023159;29.72653012465791;12.024117035061677;9.98918222413141;folK;2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase;COG0801;7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis);FolK;HELO_RS17165;H;folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase;2.7.6.3;folK;2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase;-0.03918981363578844;-0.013016412707848701;-0.14509471788241513;0.2179644044644471;0.25715421810023553
HELO_4128;341.34411772381833;174.98884128071776;205.5226837084509;212.98930210851097;157.68913692373374;199.3459686363959;9.115331429269117;8.112654396537897;6.017264146673638;14.525925445305578;12.831006696266305;10.3126320583241;panB;3-methyl-2-oxobutanoate hydroxymethyltransferase;COG0413;Ketopantoate hydroxymethyltransferase;PanB;HELO_RS17170;H;panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase;2.1.2.11;panB;3-methyl-2-oxobutanoate hydroxymethyltransferase;0.959963267273019;0.04380677064318661;-0.3362901083759988;0.7729537436164176;-0.1870095236566014
HELO_4129;392.61928996625966;179.1926855417804;246.46129396421722;237.03358203027867;215.15519156781946;271.932286120541;8.36419211406805;8.87961853798712;7.873090568855668;15.385424150839295;1.5392824117024149;9.090150256423998;panC;pantothenate synthetase;COG0414;Panthothenate synthetase;PanC;HELO_RS17175;H;panC; pantothenate synthetase;6.3.2.1;panC;pantothenate synthetase;1.1272604742247267;-0.14134017885748573;-0.33647557919806204;0.5282578578933474;-0.5990026163313793
HELO_4130;452.40382313571854;225.9880770561122;257.65958925632026;176.5444112408633;201.4322658050115;274.19323940385533;12.04181494153475;23.769037026467416;20.375405071356266;21.56996866227657;13.065743545493389;10.530445637298229;panD;aspartate 1-decarboxylase;COG0853;Aspartate 1-decarboxylase;PanD;HELO_RS17180;H;panD; aspartate 1-decarboxylase;4.1.1.11;panD;aspartate 1-decarboxylase;0.9981800366070299;-0.08939035079008484;-0.44300576776360145;0.720351527859334;-0.27782850874769593
HELO_4131;642.8766254149383;144.75460100416493;183.75481046241626;396.2062787801768;208.8351116631931;182.37723509288602;18.10701336864535;14.645661771815547;14.817220879224838;44.17587366421508;12.46811694686972;7.482999485020712;phbA;acetyl-CoA acetyltransferase;COG0183;Acetyl-CoA acetyltransferase;PaaJ;HELO_RS17185;I;phbA; acetyl-CoA acetyltransferase;2.3.1.9;phbA;acetyl-CoA acetyltransferase;2.1432428515322908;0.010797378032237681;0.19444155366921123;1.8119697266311148;-0.331273124901176
HELO_4132;36.12591097111239;118.4621427991227;106.82263773418576;94.8325488733937;93.65763517146058;101.59621199987764;2.507156933674614;8.805812039812567;7.883695603141332;4.34306396203639;9.331464755043228;5.857550173992765;HELO_4132;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS17190;G;;phbA;;HELO_4132;major facilitator superfamily transport protein;-1.686055173466202;0.07168264313880979;-0.11618668070946736;-1.4664791341869963;0.21957603927920566
HELO_4133;571.1877937178496;474.4349264209434;944.9743085378819;922.799468469791;1127.1392850352574;946.5083315951442;19.22091467030727;13.009230255894764;71.97244645047017;68.86497121417182;162.835966044513;66.77013197581445;pnp;polyribonucleotide nucleotidyltransferase;COG1185;Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase);Pnp;HELO_RS17195;J;pnp; polyribonucleotide nucleotidyltransferase;2.7.7.8;pnp;polyribonucleotide nucleotidyltransferase;0.26724083098211615;-0.002337626862392028;0.25173466590035076;-0.727649907711605;-0.9948907386937211
HELO_4134;6540.673765780051;7916.195434881091;6795.935354824597;5878.953150533443;5969.37842267174;8234.135233188092;844.2972910292406;1506.0991208854973;577.7338934791883;700.7232974050147;803.2340177799522;922.090058147864;rpsO;30S ribosomal protein S15;COG0184;Ribosomal protein S15P/S13E;RpsO;HELO_RS17200;J;rpsO; 30S ribosomal protein S15;;rpsO;30S ribosomal protein S15;-0.2753296507500682;-0.2769079398392318;-0.4639699640940407;-0.3321325275442444;-0.05680287679417617
HELO_4135;425.3513176358497;590.2372124327559;371.34921260278196;353.7345807242316;254.47433485405338;335.06222989049314;21.482098897583615;39.17441393914366;12.706843061885932;38.0379857787333;10.617061502050397;39.505190833016535;truB;tRNA pseudouridine synthase TruB;COG0130;tRNA U55 pseudouridine synthase TruB, may also work on U342 of tmRNA;TruB;HELO_RS17205;J;truB; tRNA pseudouridine synthase TruB;5.4.99.25;truB;tRNA pseudouridine synthase TruB;-0.47169436020988087;0.14792789978640464;-0.395550042735608;0.3433143083292389;0.8150086685391198
HELO_4136;438.87049351022534;983.3579252942009;151.8387962921337;160.96764146338984;136.22575584231137;158.77261930900565;21.096688924572575;135.06737959014555;13.854424677085003;21.190633974699875;16.89149810542869;20.484548633467885;rbfA;ribosome biogenesis protein RbfA;COG0858;Ribosome-binding factor RbfA;RbfA;HELO_RS17210;J;rbfA; ribosome biogenesis protein RbfA;;rbfA;ribosome biogenesis protein RbfA;-1.162104164981825;-0.06400939000745787;-0.21946890494215765;1.4610586379148751;2.6231628028967
HELO_4137;766.9155868543122;1608.4702752030792;1481.4028894366936;1500.8086564867554;1288.421449235035;1395.058406045134;35.46088350761509;76.77624313061779;123.2378733000714;53.200928409255425;54.49055697629374;26.935734842900004;infB;translation initiation factor IF-2;COG0532;Translation initiation factor IF-2, a GTPase;InfB;HELO_RS17215;J;infB; translation initiation factor IF-2;;infB;translation initiation factor IF-2;-1.0675662959078362;0.0865782985566188;-0.11463541225801244;-0.8623396634879068;0.20522663241992944
HELO_4138;607.407845304802;776.6989715688684;691.4192825440417;702.1427266733716;637.851732804981;686.4804010426986;19.68174534036423;25.553766898483516;29.092591735758216;32.379585798257004;33.795223280567875;32.7166949534837;nusA;transcription elongation factor NusA;COG0195;Transcription antitermination factor NusA, contains S1 and KH domains;NusA;HELO_RS17220;K;nusA; transcription elongation factor NusA;;nusA;transcription elongation factor NusA;-0.35417307449849567;0.010327316341117054;-0.10583744145884211;-0.17627982873869463;0.17789324575980103
HELO_4139;636.7245569809544;1139.9983326564297;633.8395320047639;883.7840122892454;596.913444857658;602.0523077760832;47.29555055138311;52.28565837717237;18.619787507672466;24.486471420411625;49.23605389951374;46.99857684116268;rimP;ribosome maturation factor RimP;COG0779;Ribosome maturation factor RimP;RimP;HELO_RS17225;J;rimP; ribosome maturation factor RimP;;rimP;ribosome maturation factor RimP;-0.8392913419019337;0.07410882426034426;-0.012346492445445278;0.08065029182635719;0.9199416337282909
HELO_4140;756.4956748550286;451.3182260850549;379.67302792031137;395.0025289803679;327.7773631699866;342.7229034532661;27.36956590463947;8.927576388061668;22.465001941864486;85.36786761975186;5.683811220543263;35.93499575331206;secG;protein translocase subunit SecG;COG1314;Protein translocase subunit SecG;SecG;HELO_RS17240;U;secG; protein translocase subunit SecG;;secG;protein translocase subunit SecG;0.7438995208273571;0.14730636658381968;-0.06413501605066863;1.1399916644117347;0.3960921435843776
HELO_4141;709.9443608629449;518.9836994911014;495.7456559169422;474.2206903891613;487.7285144802767;495.3442578502799;25.99056744584982;28.541727379468853;33.19428363083626;10.586846071502197;29.187322122160406;41.13865467816975;tpiA;triosephosphate isomerase;COG0149;Triosephosphate isomerase;TpiA;HELO_RS17245;G;tpiA; triosephosphate isomerase;5.3.1.1;tpiA;triosephosphate isomerase;0.4512702594751321;0.0011662489442372248;-0.022307822148757595;0.5183955555725213;0.06712529609738915
HELO_4142;233.54043533527434;193.26124696389653;188.81787866089485;201.06462473627803;197.6297761972772;186.3449718840077;2.270295251754942;3.2830420970483774;3.454986045029512;10.31128297780815;8.671339783984685;6.041147129630559;glmM;phosphoglucosamine mutase;COG1109;Phosphomannomutase;ManB;HELO_RS17250;G;glmM; phosphoglucosamine mutase;5.4.2.10;glmM;phosphoglucosamine mutase;0.27183854084652737;0.018918626068495037;0.08438465267189166;0.3241394103097077;0.052300869463180355
HELO_4143;154.25450617792606;162.20942715456513;139.80015118887866;150.12228415039513;149.88888578204043;146.22336052761594;3.3858006233724547;6.309659021296928;8.60754213011522;6.360723524333835;5.84725417593511;8.552998122352633;folP;dihydropteroate synthase;COG0294;Dihydropteroate synthase;FolP;HELO_RS17255;H;folP; dihydropteroate synthase;2.5.1.15;folP;dihydropteroate synthase;-0.07208924886026313;-0.06435772471274248;0.03547993549125206;0.07662853466445618;0.14871778352471932
HELO_4144;506.6537577124218;344.1472629796153;424.04623142219543;418.82062671899;460.1644276408608;418.0662650801083;11.53799899505215;7.278313033431222;28.03446550960603;26.69370685289435;22.52540277979914;3.0762070592165327;ftsH;ATP-dependent zinc metalloprotease FtsH;COG0465;ATP-dependent Zn proteases;HflB;HELO_RS17260;O;ftsH; ATP-dependent zinc metalloprotease FtsH;3.4.24.-;ftsH;ATP-dependent zinc metalloprotease FtsH;0.5566328069117219;0.020441379920153935;0.1381028447223187;0.27666646176024656;-0.27996634515147534
HELO_4145;433.9877035870838;419.7999635849362;520.2753854811864;595.2791070133222;556.5595222111284;508.2570457934471;20.377230170564903;15.016329810970907;53.45258047823487;44.84388167516289;13.326259937592948;15.313250556497882;rlmE;23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE;COG0293;23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ;RlmE;HELO_RS17265;J;rlmE; 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE;2.1.1.166;rlmE;23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE;0.04784003905298029;0.0336517021280649;0.13073179237483146;-0.2274194168089867;-0.275259455861967
HELO_4146;596.1596423650918;347.5125663842564;304.06473743977153;395.60497656440924;212.0843987194328;281.4761267410122;30.761394963135125;31.883146877985588;10.502951788267938;47.24299498532629;11.374960490234743;35.51097680130757;yhbY;probable RNA-binding protein YhbY;COG1534;RNA-binding protein YhbY;YhbY;HELO_RS17270;J;yhbY; probable RNA-binding protein YhbY;;yhbY;probable RNA-binding protein YhbY;0.7769059910412501;0.11098648344695938;-0.40670397638945843;1.0799877232183626;0.30308173217711243
HELO_4147;606.9803803403867;987.3170723578128;496.40401086828905;372.6794633433079;492.52086626601323;486.55834807007733;29.27796870834918;40.07636121325883;22.332440926687706;10.320314064712113;24.189775822052408;27.90459310840441;greA;transcription elongation factor GreA;COG0782;Transcription elongation factor, GreA/GreB family;GreA;HELO_RS17275;K;greA; transcription elongation factor GreA;;greA;transcription elongation factor GreA;-0.7009491938509136;0.028843258604315025;0.01753620139633938;0.3184498860191507;1.0193990798700643
HELO_4148;329.10225445765127;237.015876871066;363.6662219707023;334.8895486834613;573.3807180287264;367.04799123146057;11.851113816186677;16.80783812648916;40.18728858908351;37.93421987732593;44.30089690137503;31.378022983301936;carB;carbamoyl-phosphate synthase large subunit;COG0458;Carbamoylphosphate synthase large subunit;CarB;HELO_RS17280;EF;carB; carbamoyl-phosphate synthase large subunit;6.3.5.5;carB;carbamoyl-phosphate synthase large subunit;0.47185517973700275;-0.013317324265036845;0.6421134214212749;-0.15698090566742273;-0.6288360854044255
HELO_4149;468.8665924141607;347.40329339090925;485.03675542017146;499.00213525462595;671.7015755737918;480.7452649150911;14.002396107288602;10.170991849335932;25.6573638711617;29.234436173700196;28.649691197811293;37.993880246888395;carA;carbamoyl-phosphate synthase small subunit;COG0505;Carbamoylphosphate synthase small subunit;CarA;HELO_RS17285;EF;carA; carbamoyl-phosphate synthase small subunit;6.3.5.5;carA;carbamoyl-phosphate synthase small subunit;0.4314929340231153;0.01279493216670069;0.48169615088476014;-0.03601929075942323;-0.4675122247825385
HELO_4150;270.17901395670594;211.41622044949955;299.39239142568323;276.0289398949971;263.8104954419055;294.39122073415155;6.670933898545974;15.10261158645568;31.960488322015543;7.512205546655036;5.366348256348031;4.333469426692846;dapB;4-hydroxy-tetrahydrodipicolinate reductase;COG0289;4-hydroxy-tetrahydrodipicolinate reductase;DapB;HELO_RS17290;E;dapB; 4-hydroxy-tetrahydrodipicolinate reductase;1.17.1.8;dapB;4-hydroxy-tetrahydrodipicolinate reductase;0.3523515983901513;0.024221322925242816;-0.15766664593559554;-0.1233814133889819;-0.4757330117791332
HELO_4151;29.740375370076695;9.508881173191378;23.13152308197415;23.278916049529602;25.084343008905645;23.053443938970492;1.3191011921645999;0.4561870656000573;2.4579910753826826;1.882752091375263;2.876010262392736;1.6377278756112088;HELO_4151;phytase domain protein;COG4246;Uncharacterized conserved protein, contains a phytase-like domain;;HELO_RS17295;S;;dapB;;HELO_4151;phytase domain protein;1.5485257007384954;0.004675503500914502;0.11694062452758569;0.3538913099818899;-1.1946343907566055
HELO_4152;113.26997140873208;73.30596227118673;126.40070490254065;132.18144514235306;146.16205243096138;140.185317582236;10.066712373781957;0.5063243297524372;18.16936391201767;7.01691545624561;6.394687110499999;16.72006236406596;HELO_4152;DMT superfamily transport protein;;;;;;;;;HELO_4152;DMT superfamily transport protein;0.6208964511516157;-0.14821680487996236;0.05981563759227537;-0.30514373210379997;-0.9260401832554157
HELO_4153;85.22308655088693;69.10291177754853;62.477007528473386;46.996673136584384;37.48092309301186;39.73678859739062;16.702857663897507;22.881679392413396;18.412312799847854;19.165364943992383;5.877108071875101;0.7126973644495164;HELO_4153;DUF2218 family protein;COG3553;Uncharacterized conserved protein, DUF2218 domain;;HELO_RS17305;S;;;;HELO_4153;DUF2218 family protein;0.29859983906909626;0.6399018645417573;-0.0821888454660451;1.0817419551497727;0.7831421160806764
HELO_4154;163.67052041031823;74.01099000952424;172.41365995099395;119.17133903481935;132.78982871628605;186.64159429243156;8.00019180533373;2.462490053629609;41.67073651718771;5.504745795832828;9.027138958659911;68.71264190429974;HELO_4154;ABC-type transport system periplasmic substrate-binding protein;COG0614;ABC-type Fe3+-hydroxamate transport system, periplasmic component;FepB;HELO_RS17310;P;;;;HELO_4154;ABC-type transport system periplasmic substrate-binding protein;1.134408416190377;-0.11376211839303796;-0.48801122361645444;-0.18839735930262425;-1.3228057754930012
HELO_4155;212.67570717600813;92.45255976751632;140.1836339044232;101.67728520359013;121.14159163578711;154.90302911575301;4.999558797736842;4.287503029340482;27.224632145119227;9.0653029887391;4.900422958823929;54.19481455298362;HELO_4155;ABC-type transport system permease protein;COG0609;ABC-type Fe3+-siderophore transport system, permease component;FepD;HELO_RS17315;P;;;;HELO_4155;ABC-type transport system permease protein;1.1931168104851828;-0.1430760989457669;-0.3520944088531932;0.45477393796840726;-0.7383428725167756
HELO_4156;240.00427322137082;114.097362098858;208.2043624509379;157.31199917855284;208.26006218341524;214.43985347984764;7.231737410697192;4.120230961798732;42.91311987632432;13.651522333560997;11.510296238598258;55.180957518070905;HELO_4156;ABC-type transport system ATP-binding protein;COG1120;ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component;FepC;HELO_RS17320;HP;;;7.2.2.-;HELO_4156;ABC-type transport system ATP-binding protein;1.0662039580425757;-0.04237221796506496;-0.041988157941952764;0.1617735731768013;-0.9044303848657744
HELO_4157;142.99440209916352;103.46322575131683;132.27215712567337;172.50128040926333;129.53303729467754;131.89047540355088;12.69477550803393;5.193363299610278;3.8103852742450552;8.01492948157304;14.204602050874378;18.085075165208902;HELO_4157;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS17325;GER;;;;HELO_4157;DMT superfamily transport protein;0.4630175678771886;0.004137701073401168;-0.025822714411967596;0.1157750200839116;-0.347242547793277
HELO_4158;525.3799276757718;667.4548457286563;605.0495641071778;1074.0233525079566;439.99979740319833;583.3123288463427;63.350859862719716;2.272116374448928;37.312075902760164;52.019434945165656;34.77499533537197;34.22939537758174;dnaJ;molecular chaperone DnaJ;COG0484;DnaJ-class molecular chaperone with C-terminal Zn finger domain;DnaJ;HELO_RS17335;O;dnaJ; molecular chaperone DnaJ;;dnaJ;molecular chaperone DnaJ;-0.3447256330785802;0.052696055279504606;-0.40596173711046646;-0.15063525394922017;0.19409037912936
HELO_4159;986.4996304189075;1124.037362846517;1214.084602169017;2632.5890822985984;933.764133438478;1173.071501422597;159.26122667644614;1.91292837987341;92.39289265340838;245.24723902130452;69.68749197652394;108.6440754285621;dnaK;chaperone protein DnaK;COG0443;Molecular chaperone DnaK (HSP70);DnaK;HELO_RS17340;O;dnaK; chaperone protein DnaK;;dnaK;chaperone protein DnaK;-0.1881208012488056;0.04953649540389016;-0.3288459872180045;-0.24966815847916024;-0.06154735723035465
HELO_4160;212.3491316280362;225.1175374261227;274.12435603044446;532.4434990766362;192.86942818872856;273.4128545485233;23.95072199437709;14.360353660348167;33.800363378409656;42.88433854083173;5.887009798235823;19.01316483585072;grpE;molecular chaperone GrpE;COG0576;Molecular chaperone GrpE (heat shock protein HSP-70);GrpE;HELO_RS17345;O;grpE; molecular chaperone GrpE;;grpE;molecular chaperone GrpE;-0.08385665175571155;0.0037357988262236574;-0.5012627456791776;-0.36313182594689675;-0.2792751741911852
HELO_4161;157.66041829983544;207.4826133071705;165.9666906359556;179.2868919266632;143.32068602068483;154.68636801795466;6.723367714333887;4.668480070636883;6.462584538741405;9.287013629073142;7.759935177105022;10.043868016105769;recN;DNA repair protein RecN;COG0497;DNA repair ATPase RecN;RecN;HELO_RS17350;L;recN; DNA repair protein RecN;;recN;DNA repair protein RecN;-0.3939848154650907;0.10091769119004912;-0.10936452529786944;0.027299630900310845;0.4212844463654015
HELO_4162;940.3188158848442;904.394914075991;1255.7042760946927;1071.9077628394396;922.8252775984743;1110.2173958450503;123.92021504766052;43.77926145451959;151.57172536924455;211.4230555652483;21.869775008557834;10.536457134206152;fur;Fur family transcription regulator Fur;COG0735;Fe2+ or Zn2+ uptake regulation protein Fur/Zur;Fur;HELO_RS17355;P;fur; Fur family transcription regulator Fur;;fur;Fur family transcription regulator Fur;0.05613623056603245;0.1775041093405214;-0.26644916296627663;-0.23938575149977304;-0.2955219820658055
HELO_4163;340.28707327020555;287.8152705007232;730.6274791997885;612.7239351068041;695.078738602518;746.8943805230401;9.677668593410443;23.824796600407073;71.68756846795787;32.85061696940393;52.81789185370378;51.559254183913;bamE;outer membrane protein assembly factor BamE;COG2913;Outer membrane protein assembly factor BamE, lipoprotein component of the BamABCDE complex;BamE;HELO_RS17360;M;bamE; outer membrane protein assembly factor BamE;;bamE;outer membrane protein assembly factor BamE;0.24083874764848723;-0.03172528127550045;-0.10358403438277364;-1.1318487722094215;-1.3726875198579087
HELO_4164;135.30209532983284;113.0442121408105;76.06515288956628;75.12291401118449;66.05410922924612;62.6567035377785;7.928430360683597;3.9964304724444104;0.6403593613868708;10.082150172246427;9.481086281887483;0.7116744369733119;HELO_4164;UPF0125 family protein;COG2914;Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily;PasI;HELO_RS17365;V;;bamE;;HELO_4164;UPF0125 family protein;0.25721451014248586;0.27576620473147884;0.07501329754277819;1.0984233863549369;0.841208876212451
HELO_4165;158.21995462995787;124.12844304026176;191.82886044978773;218.83508248318094;156.4839421227231;174.88509194879552;5.787703406408603;7.854735188395554;9.171409354806537;4.111635165683434;5.565637240394137;4.799501409073034;ratA;ribosome association toxin RatA;COG2867;Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module;PasT;HELO_RS17370;J;ratA; ribosome association toxin RatA;;ratA;ribosome association toxin RatA;0.3476113896211066;0.13268778914872836;-0.15942847344401034;-0.1436120484128267;-0.4912234380339333
HELO_4166;237.98757215473714;210.57053907798596;141.39842156664642;153.63680155142143;133.22215047912607;132.00193015477967;8.855649570636738;8.319064068433113;5.895887046771345;17.337185472428168;23.821447887234022;12.666475121479511;smpB;SsrA-binding protein;COG0691;tmRNA-binding protein;SmpB;HELO_RS17375;O;smpB; SsrA-binding protein;;smpB;SsrA-binding protein;0.1757968490151507;0.09848597205431275;0.013175594370586907;0.8454884144448283;0.6696915654296776
HELO_4167;377.5532756767768;1251.3760707861663;802.6175804775647;863.988685631614;757.7993256246115;746.9292114762243;8.073455416985176;30.27469844144088;56.444593530838816;78.96901220238456;66.57309877631901;59.410406336556576;HELO_4167;UPF0150 family protein;COG1598;Antitoxin component HicB of the HicAB toxin-antitoxin system;HicB;HELO_RS17400;V;;;;HELO_4167;UPF0150 family protein;-1.7260995909760108;0.10360739455220624;0.020816665339763674;-0.9824053791134997;0.7436942118625112
HELO_4168;10.000912824842997;8.823865156493556;3.7692310799021587;3.184558567584211;2.9803063949692814;3.109672796043169;0.6055510251197735;1.3234172535841122;1.0179079971755665;0.3948648516529276;1.1441674762786138;1.3415786067883604;HELO_4168;uncharacterized protein;;;;;;;;;HELO_4168;uncharacterized protein;0.16326057614051814;0.21473315224834622;-0.04614404353620749;1.4205278004102437;1.2572672242697256
HELO_4169;3.974013783067899;4.355173743387799;4.493037701889549;2.7424069883104156;5.230034480030064;4.732486876212357;0.15438629636347717;0.1495415507203155;0.40228547610539206;0.16292616458992804;1.0913619096452711;0.3221855349447466;HELO_4169;uncharacterized protein;;;;;;;;;HELO_4169;uncharacterized protein;-0.10652287727773668;-0.06155695300655806;0.12007900089884416;-0.20475064165578072;-0.09822776437804404
HELO_4170;1.9025845588176027;2.67925630998004;1.8245876738638607;1.6117403574487508;2.8063056359666176;2.7040391962315176;0.4586417610036654;0.4000393601412199;0.09755460115331059;0.2649118320306541;0.7173730649323355;0.740983338279286;HELO_4170;uncharacterized protein;;;;;;;;;HELO_4170;uncharacterized protein;-0.34207608638516307;-0.3910590833732124;0.03929204542977982;-0.35176126865745694;-0.009685182272293869
HELO_4171;4.221706048890604;8.543482024345908;6.481646883470046;4.215076522109517;6.3384587740623966;6.762379114596357;0.25348015447409755;0.8976322971468707;0.9652128341839576;0.19335003875383966;0.4877944829396116;1.2534157849054073;HELO_4171;uncharacterized protein;;;;;;;;;HELO_4171;uncharacterized protein;-0.8699944976513767;-0.05314302046303787;-0.08102179655635267;-0.571977651315446;0.29801684633593073
HELO_4172;2.496553587312724;4.410195160743829;0.3695806054903632;0.2269810021757658;0.2206866433482383;0.6707150851252147;0.13456492264991546;0.7925682272169569;0.1960166249236132;0.22815284930790644;0.38224047883098095;0.6010483653970664;HELO_4172;homolog to phage protein HAPgp19;;;;;;;;;HELO_4172;homolog to phage protein HAPgp19;-0.6297470212583849;-0.28673154770751397;-0.45277282434459193;1.0654678909164224;1.6952149121748072
HELO_4173;3.9406552484204855;6.487442652348289;7.826153750104332;5.690376974942833;7.003524790627769;7.794926220947473;0.10602172954247763;0.24776320264400686;0.6701600383822905;0.5965579416935036;0.5171489917391914;0.4464867577700142;HELO_4173;uncharacterized protein;COG5126;Ca2+-binding protein, EF-hand superfamily;FRQ1;HELO_RS17430;T;;;;HELO_4173;uncharacterized protein;-0.5997706579044761;0.005113403797142979;-0.13603596548635188;-0.8319690850570813;-0.2321984271526052
HELO_4174;131.50766658158204;103.98860884146772;106.11438738535712;87.98273450993041;88.6025051352212;94.2494866246072;11.928993359557237;15.632977086999706;5.924699083320143;16.727754136010194;12.461205995462354;16.138184115463087;HELO_4174;uncharacterized protein;;;;;;;;;HELO_4174;uncharacterized protein;0.33584302760803375;0.16936905104330613;-0.08817224862189121;0.4762926111224841;0.14044958351445036
HELO_4175;1.1072324728978564;7.401114435463442;6.760651229891224;1.5227770944830867;4.375611057669754;8.187562705968338;0.1997602550116232;0.8909231419908148;1.5590883131277014;0.27150380829204823;0.5426819738263488;1.7266746763299283;HELO_4175;APSES domain protein;;;;;;;;;HELO_4175;APSES domain protein;-1.9952312357146715;-0.2435044711096781;-0.7732534330186183;-2.1243327082836228;-0.12910147256895144
HELO_4176;3.0795962673858455;21.551472216367383;11.398334890077194;2.639274959630618;6.33117005618303;10.722467429388265;0.40678276195339774;2.5203826620890184;1.740635906346675;1.0052909978893652;1.6148281846112902;0.25904677316995284;HELO_4176;DUF1799 domain protein;;;;;;;;;HELO_4176;DUF1799 domain protein;-2.4667233295900326;0.08087010753279511;-0.6771608943083112;-1.5227779808721404;0.9439453487178922
HELO_4177;2.077908200089721;22.431867649743882;12.670693950650554;2.461839852497418;7.8628342462012215;16.84438658472139;0.15601981049052085;0.7631094241927279;3.1352259727938545;0.7738641297948846;0.8792111924595953;1.7259297406515433;HELO_4177;uncharacterized protein;;;;;;;;;HELO_4177;uncharacterized protein;-2.92844984114386;-0.38438382965512075;-1.0096302712297045;-2.5354481999934935;0.3930016411503665
HELO_4178;2.7488346373967247;23.235961650877016;20.715202886561723;6.377924343892546;19.4579128567776;27.519206991073915;0.3659371478360477;1.8209273887925308;3.311078480515187;1.1221508221903755;0.7986233376682425;4.344727883092705;HELO_4178;uncharacterized protein;;;;;;;;;HELO_4178;uncharacterized protein;-2.6926352335857704;-0.3932284345171695;-0.47927489962414427;-2.9274197722823496;-0.23478453869657923
HELO_4179;1.1247760084840643;25.923575453461982;3.149817975092734;0.9595528569741947;1.5305160331270706;4.720032377999255;0.6639540671099827;1.7230444752609033;1.7312557223843883;1.0880044260922241;1.090586760973435;2.1222088070319725;HELO_4179;uncharacterized protein;;;;;;;;;HELO_4179;uncharacterized protein;-3.6634873456364976;-0.4629752569268133;-1.1765916981759983;-1.4287125513757117;2.234774794260786
HELO_4180;10.043256852526646;29.47790415126774;12.352048138228616;3.8455064007511965;10.470152154555711;14.082670141936688;0.6279514442349566;1.408246254116274;3.4521519200196336;0.6378201509488458;1.5370764476481509;3.969100330714273;HELO_4180;uncharacterized protein;;;;;;;;;HELO_4180;uncharacterized protein;-1.4645979863776946;-0.17583079577645933;-0.39500732775094516;-0.449726145704763;1.0148718406729316
HELO_4181;8.020206574742568;22.1857046172247;14.997470405315417;6.76870806739261;11.523311888634899;17.656656601537836;0.6660908930774924;1.488337769657694;3.022385336534254;0.9251948994545051;1.5758990110877082;4.103195839817706;HELO_4181;uncharacterized protein;;;;;;;;;HELO_4181;uncharacterized protein;-1.362003192499511;-0.2218466712156606;-0.575074323874174;-1.048458090080004;0.31354510241950706
HELO_4182;6.014673133126205;19.313259851279053;20.929558396443397;8.221016599332529;16.70623571588442;24.462382559679895;0.6331591928597683;1.4026396860056483;4.121126013374803;1.0028316357647384;0.48644076074478715;5.797302785593538;HELO_4182;uncharacterized protein;;;;;;;;;HELO_4182;uncharacterized protein;-1.5339739960362402;-0.21549066082926682;-0.5241098883129656;-1.8599196366446216;-0.3259456406083814
HELO_4183;5.4570997067558205;24.698115921645577;34.097224900391346;12.523963799824175;25.70505754868249;38.66666984722892;0.9705853613950857;2.020349553001486;2.2530416701190736;1.6844095398894636;1.9911648222454372;2.761793421409702;HELO_4183;major capsid protein E;;;;;;;;;HELO_4183;major capsid protein E;-1.992704381308657;-0.17657032067489453;-0.5708142901754414;-2.6189690737553;-0.6262646924466431
HELO_4184;3.4823372721323698;24.682474852978597;12.087996715690595;3.4555705586634153;10.067757305633704;12.112021896455673;0.2473171801475569;1.6202380854323002;2.213928036704745;0.25622454659206606;1.0719652228754901;4.139744190484614;HELO_4184;phage head decoration protein D;;;;;;;;;HELO_4184;phage head decoration protein D;-2.5184611190883994;-0.0026458774227999804;-0.2445272548700652;-1.5485670555807252;0.9698940635076743
HELO_4185;1.2697818827983582;15.023196821179065;10.079861063586618;2.5144784544072336;8.272975955275935;13.268314489518412;0.1939675195314776;0.49451602200838635;0.649825196696485;0.4314600240243004;0.7062595029337648;1.4762368183304933;HELO_4185;peptidase S49 family protein;COG0616;Periplasmic serine protease, ClpP class;SppA;HELO_RS17500;O;;;3.4.21.-;HELO_4185;peptidase S49 family protein;-2.819536439625611;-0.36487512910932285;-0.6217106007283548;-2.652189347957558;0.1673470916680535
HELO_4186;4.520932818137215;9.088919954635822;7.604719518203993;4.86158541992;8.080646651295512;9.421786976918355;0.20079458902136968;0.5344216724099711;0.19326351619642176;0.30104817684608204;0.9990236842598014;1.5792865647130276;HELO_4186;phage portal protein;COG5511;Phage capsid protein;;HELO_RS17505;X;;;;HELO_4186;phage portal protein;-0.869787787607049;-0.27640259959223545;-0.198735727721993;-0.91661872044146;-0.04683093283441098
HELO_4187;2.04090206163259;9.255634238974771;0.25667068739867294;0.09685130629577964;0.190280928042481;0.4772328227390485;0.36873686027734015;0.587792936524177;0.4445666713881303;0.16775138328370578;0.3295762350809347;0.44329963615185974;HELO_4187;uncharacterized protein;;;;;;;;;HELO_4187;uncharacterized protein;-1.7538454578021652;-0.23329058465476943;-0.31159510724793293;1.041602128867337;2.795447586669502
HELO_4188;4.926919851000179;7.95152564499161;7.433207038657138;5.330138096853342;6.3206226989504595;7.871244544025849;0.40514353223829824;0.9318397566982884;0.957615646414926;0.48969093469231373;0.32590435578978333;1.7979375880249888;HELO_4188;homolog to phage terminase large subunit;COG5525;Phage terminase, large subunit GpA;gpA1;HELO_RS17515;X;;;;HELO_4188;homolog to phage terminase large subunit;-0.5948510394754964;-0.07305514032173877;-0.27717014323911515;-0.5818539656931243;0.012997073782372137
HELO_4189;7.9455663805234;8.68545777358632;9.448253955130335;6.194114234099178;6.515175356549911;7.227465366923916;0.23544071024396598;1.3214694655355195;1.6409091236742397;1.4556380430984188;1.2654125326872;1.4505557090186887;HELO_4189;homolog to phage terminase small subunit;COG4220;Phage DNA packaging protein, Nu1 subunit of terminase;Nu1;HELO_RS17520;X;;;;HELO_4189;homolog to phage terminase small subunit;-0.11464740988146627;0.3447419150235045;-0.13064128052408464;0.12072477969865947;0.23537218958012573
HELO_4190;1.6455358832739122;11.099959908646818;4.4826521732409965;1.195125191109401;3.0127596115298574;3.707340360467089;0.2711365672201618;1.4378781539318457;1.4184336722180835;0.7571937941962715;0.8848840336574914;1.0844523453640307;HELO_4190;uncharacterized protein;;;;;;;;;HELO_4190;uncharacterized protein;-2.193370376076408;0.21996178033657987;-0.23031743712161346;-0.831352183534668;1.3620181925417403
HELO_4191;0.886850908471002;9.384188485083266;3.0418758893527547;0.4582661048612818;2.2889486077391648;4.368874718623013;0.45885673954139755;1.0175700609366187;0.7423922616484723;0.23151909641810448;1.3082003473131514;1.7099470230318077;HELO_4191;phage holin domain protein;;;;;;;;;HELO_4191;phage holin domain protein;-2.4603361388049354;-0.4095947176396031;-0.7069932751860599;-1.5086393089950887;0.9516968298098467
HELO_4192;0.8955802519855255;12.606114421110851;9.456910484734273;2.4689155336785213;5.9733880990542785;10.883822658323254;0.09966721538943593;0.3735001850917746;1.3405272341124261;0.9822645434610154;0.19580063894306313;2.273439272828124;HELO_4192;hydrolase domain protein;COG0860;N-acetylmuramoyl-L-alanine amidase;AmiC;HELO_RS17540;M;;;3.5.1.28;HELO_4192;hydrolase domain protein;-2.8435436852854297;-0.1845423137979738;-0.7690673000237216;-2.6482875397982704;0.1952561454871593
HELO_4193;15.682099291285446;13.824896639179249;16.628995166871388;12.13020557540802;12.783612960039171;14.806715028695882;1.0423342513278628;0.919233089338677;2.661283347185331;1.554730095813074;3.41969222384674;3.4816837919796617;HELO_4193;uncharacterized protein;;;;;;;;;HELO_4193;uncharacterized protein;0.17027880414989127;0.15741266883053395;-0.19758347938259568;0.07776327416931039;-0.09251552998058088
HELO_4194;8.672272868732287;10.470338399140077;16.826954013019456;10.008437244553532;12.050948675466472;15.75430863084179;1.116917211271321;0.3488626055424811;1.414587480299921;0.821977046089936;1.5272430025580337;1.3798808338253903;HELO_4194;uncharacterized protein;;;;;;;;;HELO_4194;uncharacterized protein;-0.2459811037473325;0.0895280644526677;-0.36037747440359036;-0.7926053039584646;-0.5466242002111321
HELO_4195;16.951611808164007;23.806954136967505;37.16142530683584;17.230711088366885;20.240472256956945;34.877204366057605;1.4154799002601088;3.4539937029805583;3.4204546447800523;3.5198399464145265;2.4929382881153757;5.793003001558608;HELO_4195;toprim domain protein;COG4643;Uncharacterized domain associated with phage/plasmid primase;;HELO_RS17555;X;;;;HELO_4195;toprim domain protein;-0.46663122415278213;0.08904757962793397;-0.7562516334060732;-0.9989540924725038;-0.5323228683197216
HELO_4196;53.765936065194914;55.63009080076977;130.0340601472674;117.25458707483888;130.82841890359575;129.58987272872196;2.3442604855980673;5.50149122747881;14.49454494128936;2.302854665477255;5.038890712557165;6.765194220702499;HELO_4196;uncharacterized protein;;;;;;;;;HELO_4196;uncharacterized protein;-0.048290014645139934;0.00489884541262775;0.013618392844108484;-1.2536922864133437;-1.2054022717682038
HELO_4197;14.134896079737159;17.40153875243406;28.37097639923404;8.922802779960792;14.923145457908902;28.512472589291264;1.1880499434524328;1.529189690885872;2.4705101930799818;2.444682798511952;1.3719480841214893;4.742956703162931;HELO_4197;uncharacterized protein;;;;;;;;;HELO_4197;uncharacterized protein;-0.281947641454082;-0.006933569555634733;-0.8901994425127278;-0.9634460272349767;-0.6814983857808947
HELO_4198;4.738795330674467;10.30645530145175;1.3662779585966784;0.17302351953586959;1.277079209470597;1.5944684843968624;1.395806257961446;1.4979341186912896;1.3746889081708846;0.14996872218042867;0.40650013728095463;1.0684506277323886;HELO_4198;uncharacterized protein;;;;;;;;;HELO_4198;uncharacterized protein;-0.9783268714665754;-0.13281945914082005;-0.18825453393664682;1.1453089115773374;2.1236357830439125
HELO_4199;0.9232495314440351;2.984119415612931;1.3810640404673051;0.32675005813027985;0.5814338295353694;1.7153199086050106;0.28196557134598965;0.3355938650224265;1.4429073452333363;0.11759876539720683;0.18918015162299534;0.6051285830783423;HELO_4199;uncharacterized protein;;;;;;;;;HELO_4199;uncharacterized protein;-1.0507149329432863;-0.18951575738084525;-0.7798889890827075;-0.4975762239893402;0.5531387089539461
HELO_4200;0.8335341559645286;3.060763294712109;0.3104887347564592;0.0;0.35707662972032445;0.11776413272901172;0.7729808692788891;1.2798085646762911;0.5377822637759642;0.0;0.3458731084351644;0.20397346119593324;HELO_4200;uncharacterized protein;;;;;;;;;HELO_4200;uncharacterized protein;-1.1471237922892725;0.22948916493250412;0.27988640030177003;0.7140113544539313;1.8611351467432036
HELO_4201;1.2322739606835116;3.7588814838231888;1.6890730878926163;0.3084201912564984;1.7668416621402283;3.816107638493024;0.7000255163034104;0.6499392115077766;0.7715716825341927;0.3569639859570816;0.9634805773734981;1.1063164038998006;HELO_4201;Ant_Cterm domain protein;;;;;;;;;HELO_4201;Ant_Cterm domain protein;-1.0921084298438104;-0.840758668641695;-0.7996275509398947;-1.109353540315119;-0.0172451104713085
HELO_4202;0.871582586549479;2.711779051453343;2.4837193620227347;0.7925104950726608;1.4731628020743208;3.1900411382081497;0.36480447353801937;1.0044912660313514;1.1694141507545979;0.3734348699186893;0.8112445882782539;1.2870624446307906;prtN;PrtN family transcription regulator PrtN;;;;;;;;;prtN;PrtN family transcription regulator PrtN;-0.9878521238461754;-0.2663359990717258;-0.7606071966739874;-1.1627056976574641;-0.17485357381128885
HELO_4203;1.6913567674797563;9.825316942443697;16.491111838760173;3.742648181896756;8.414564290152562;22.335448007184564;0.24054401374326825;0.9224543190767981;6.322988190911344;2.175806623905603;2.2820274160511933;8.951471914713858;yfdP1;YfdP family protein;;;;;;;;;yfdP1;YfdP family protein;-2.008003711557758;-0.41590116682289047;-1.3095569322602625;-3.11611761216676;-1.1081139006090024
HELO_4204;1.464901331959316;9.07519394133273;24.27023742150818;5.682010380998167;10.709636605239751;26.72067746610546;0.4465128874080602;0.5612334997939936;7.739753842470986;0.258215119510379;1.7782008561630835;7.299257343320528;yfdQ1;YfdQ family protein;COG5532;Uncharacterized conserved protein YfdQ, DUF2303 family;yfdQ;HELO_RS17630;S;yfdQ1; YfdQ family protein;;yfdQ1;YfdQ family protein;-2.0312058070832295;-0.13352329705273824;-1.243266211759535;-3.4913607130183624;-1.4601549059351329
HELO_4205;0.7899415715735217;2.55622901763763;6.480521875311347;1.8307594490021206;2.6074387712136473;7.567300017098944;0.31390225018390483;0.2551026343466296;2.9949001879344435;0.32343832791957816;0.20784895904011716;2.624472148736488;HELO_4205;uncharacterized protein;;;;;;;;;HELO_4205;uncharacterized protein;-0.9904357404189176;-0.1957016883029974;-1.2478657027404603;-2.2589281160338177;-1.2684923756149002
HELO_4206;1.1108848415463148;2.1566486938029272;4.489422755130515;1.4615080329244112;2.6115419406506426;5.868219920486375;0.04207482559211205;0.11652001209491618;1.4697370041817888;0.1526549467730503;0.5670052478553138;2.0435656735121213;HELO_4206;probable methyltransferase (homolog to DNA-cytosine methyltransferase);COG0270;DNA-cytosine methylase;Dcm;HELO_RS17645;L;;;2.1.1.37;HELO_4206;probable methyltransferase (homolog to DNA-cytosine methyltransferase);-0.5805458355925566;-0.32328178579735045;-0.9273213107730165;-1.7020883599948813;-1.1215425244023247
HELO_4207;1.8307541260500686;1.5041035406164953;2.434246188452289;1.4647509583555973;1.8478351728194429;2.6616907160430365;0.3344350242136637;0.09348481046334944;0.8893327587037758;0.48480594379923975;0.10943919662526312;0.7371134204205422;HELO_4207;integrase family protein;COG4974;Site-specific recombinase XerD;XerD;HELO_RS17655;L;;;;HELO_4207;integrase family protein;0.17689222832070994;-0.09251647480230463;-0.36264429101220497;-0.37132349441732093;-0.5482157227380309
HELO_4208;21.71390796024617;2.4496941823840817;21.18409141610863;35.49867809703817;31.661360092593696;18.1142963444087;1.0694065535955897;0.49147247056972254;1.83696537315302;1.9609950756010286;8.268121846684924;1.797269883791394;HELO_4208;UspA domain protein;COG0589;Nucleotide-binding universal stress protein,  UspA family;UspA;HELO_RS17665;T;;;;HELO_4208;UspA domain protein;2.7190355683133385;0.21487337541171403;0.7729327780791415;0.24892385399679817;-2.4701117143165403
HELO_4209;49.38897867207243;22.96161893664716;69.69350880653161;61.1506854234984;75.06316138289415;67.18729460720577;2.3508446736823942;0.7533715134323611;7.747652053568605;1.3775032471137167;9.991817225958512;4.041756579986703;HELO_4209;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS17670;K;;;;HELO_4209;LysR family transcription regulator;1.0723828295023923;0.05207480472318782;0.1576949565968384;-0.43639473097934456;-1.5087775604817368
HELO_4210;5.2015992834256;3.6149767686477605;12.81939824282791;10.851770404920485;16.095001210463124;13.804226518270468;0.1850634810400159;0.17341668638223007;0.5942605616253501;1.1933309132799754;1.946654129611451;0.6004278775578046;rhmD;L-rhamnonate dehydratase;COG4948;L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily;RspA;HELO_RS17675;MR;rhmD; L-rhamnonate dehydratase;4.2.1.90;rhmD;L-rhamnonate dehydratase;0.42631692366667817;-0.09931431965133308;0.20756540944610347;-1.2552969011999697;-1.681613824866648
HELO_4211;5.028906973251169;3.0551418679000037;2.497894862653816;1.9154563907074724;4.199565912229948;3.406218470127866;1.61973831723891;0.4175239685550233;0.4880090272513869;0.47421633021108556;1.3429447878722065;0.9144160548110138;rhaM;L-rhamnose mutarotase;COG3254;L-rhamnose mutarotase;RhaM;HELO_RS17680;M;rhaM; L-rhamnose mutarotase;5.1.3.32;rhaM;L-rhamnose mutarotase;0.5721440810211056;-0.33305410248201683;0.2388501554815905;0.45235543974566994;-0.11978864127543565
HELO_4212;8.22484092850074;7.365863896588354;12.027127552845954;10.636844985327686;15.842140965191183;13.97801295848146;0.31512249102747797;0.8478223582053791;1.4160927114338488;0.589912565259299;0.9435531025232319;0.4720895974127179;HELO_4212;amidohydrolase domain protein;COG3618;Predicted metal-dependent hydrolase, TIM-barrel fold;;HELO_RS17685;R;;rhaM;;HELO_4212;amidohydrolase domain protein;0.14100950670343781;-0.20132723441636458;0.16922930184044693;-0.6992503040234128;-0.8402598107268506
HELO_4213;7.624373749782838;7.4254982738558795;11.966279779661924;7.974610292169248;15.724509078582647;12.57832197823214;1.432195568403283;1.0803361664740838;1.0530776713994328;0.7500296049628;1.7669134082691142;0.19291042089535534;rhaD;L-rhamnose-1-dehydrogenase;COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS17690;I;rhaD; L-rhamnose-1-dehydrogenase;1.1.1.378,1.1.1.377,1.1.1.173;rhaD;L-rhamnose-1-dehydrogenase;0.03365769266288199;-0.06654059289918557;0.30065866247351014;-0.654813595145602;-0.688471287808484
HELO_4214;10.241457157017033;11.569670378764506;21.995536338544344;16.759008295863833;31.782103802453765;24.73559222129541;2.2743892692995678;1.8732599667839949;1.041069112780722;1.7815974776682146;2.843107918157566;4.763009214699804;hpcH;2%2C4-dihydroxyhept-2-ene-1%2C7-dioate aldolase;COG3836;2-keto-3-deoxy-L-rhamnonate aldolase RhmA;HpcH;HELO_RS17695;G;hpcH; 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase;4.1.2.52;hpcH;2%2C4-dihydroxyhept-2-ene-1%2C7-dioate aldolase;-0.16111776282530021;-0.16241113493671033;0.3491434609643491;-1.1949359270196314;-1.0338181641943311
HELO_4215;9.155145040263694;9.48977004637295;28.678233049564295;15.851114295431396;48.23390263935185;31.644762155197697;0.9813401780367085;0.6390527544916227;1.684946304290683;1.0335862598569692;4.1367344677497195;0.4685062373931941;aldA;lactaldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS17700;I;aldA; lactaldehyde dehydrogenase;1.2.1.22,1.2.1.21;aldA;lactaldehyde dehydrogenase;-0.04677220694057471;-0.13744632933920098;0.5928005724272989;-1.6846406852542901;-1.6378684783137154
HELO_4216;6.538879591311894;9.404697372850485;19.34615357912925;10.49771580989556;32.172641469685786;22.06373044067807;0.5068910319705308;0.29669738070251417;2.4435327111455765;1.1368586385373494;0.9679365898499068;2.560672762942548;HELO_4216;probable NCS1 family transport protein;;;;;;;;;HELO_4216;probable NCS1 family transport protein;-0.4648129690425735;-0.18086980027080024;0.5243680151370702;-1.6132038454716255;-1.148390876429052
HELO_4217;2.0027327721029557;1.5323571082709775;3.760177988079255;2.0325205095194545;5.058623253978978;4.271047925394694;0.1889237461728295;0.2602622206336913;0.28242851828128057;0.16242945423113408;0.17521763422965428;0.7385469140559644;HELO_4217;GntP family transport protein;COG2610;H+/gluconate symporter GntT or related permease, GntP/DsdX family;GntT;HELO_RS17715;G;;;;HELO_4217;GntP family transport protein;0.24579522283646393;-0.14707429095939917;0.20090018722551894;-0.8118137212817458;-1.0576089441182097
HELO_4218;156.02785356365618;129.78490150919512;165.347461029905;153.0759697280476;146.40806642186888;169.49728541961562;5.852636228120247;1.5512682599192413;7.771579932684421;5.522654287093609;8.878266357992764;5.225940772985662;ydiJ;YdiJ family protein;COG0277;FAD/FMN-containing lactate dehydrogenase/glycolate oxidase;GlcD;HELO_RS17720;C;ydiJ; YdiJ family protein;;ydiJ;YdiJ family protein;0.263824488509222;-0.035548923038630775;-0.20993329616001155;-0.11872828277465253;-0.38255277128387455
HELO_4219;16.975582804996847;10.340849625793778;21.310961805177914;23.421113856188825;27.304367171296462;22.038945243785538;2.3526806191546847;0.9178049800432015;0.5436189633185803;1.6166731997175556;2.943405724316103;3.2556154137443625;HELO_4219;uncharacterized protein;;;;;;;;;HELO_4219;uncharacterized protein;0.6645098193926446;-0.04632196144013001;0.29694999863379046;-0.3580361230940561;-1.0225459424867007
HELO_4220;21.205947091564443;11.107745486904603;26.23970169229257;22.40550734147135;23.0099478354154;25.181949361372645;0.9613784432187967;0.795350792123582;2.3493052269225325;1.8514607144043618;2.662955435629938;1.9086857238211534;HELO_4220;AraC family transcription regulator;COG2207;AraC-type DNA-binding domain and AraC-containing proteins;AraC;HELO_RS17730;K;;;;HELO_4220;AraC family transcription regulator;0.8750158499155303;0.057138387901316534;-0.12494024713996232;-0.23762641220274094;-1.1126422621182712
HELO_4221;73.00619234658629;19.616229958751912;142.8676609308434;211.22642518475877;175.8143629443341;145.78373762130389;10.037914473812457;1.4576026111963412;14.97096090047075;16.825469740584865;30.05434160619959;7.099508883396977;HELO_4221;DUF952 domain protein;COG3502;Uncharacterized conserved protein, DUF952 family;;HELO_RS17735;S;;;;HELO_4221;DUF952 domain protein;1.8438654563371504;-0.028949804250661515;0.26854333336381053;-0.9879742427602043;-2.8318396990973547
HELO_4222;27.515783433757075;14.774690215762137;23.686967091013713;23.404480233461083;28.756528221814666;23.478336838190312;1.1502518815279095;1.3680334187577956;0.9908475718324625;1.740787206142579;2.3402980181118704;1.9869165516711116;HELO_4222;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS17740;K;;;;HELO_4222;LysR family transcription regulator;0.854148995645446;0.01224406700319669;0.28170067440656066;0.22025513085339643;-0.6338938647920496
HELO_4223;46.9920866946617;45.203277200829;100.35326498209146;192.49383527624354;123.4820041172356;103.36380934928862;2.0354694870237533;3.809917909010819;7.268512103186364;7.098574064193179;9.910514718088725;9.542370144258658;HELO_4223;TRAP transporter substrate-binding protein (probable substrate D-Ala-D-Ala);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS17745;G;;;;HELO_4223;TRAP transporter substrate-binding protein (probable substrate D-Ala-D-Ala);0.05480135705599398;-0.042228945208328206;0.2543156829460198;-1.1207530616963837;-1.1755544187523777
HELO_4224;24.103406279186355;32.69714897576615;16.81585129334342;31.490847035398208;23.599841802897913;22.262749495959223;1.702640774190383;3.5206356866535184;1.8819353841345918;2.081607789442908;6.346244639653738;0.5213000793498452;HELO_4224;TRAP transporter small transmembrane protein (probable substrate D-Ala-D-Ala);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS17750;G;;;;HELO_4224;TRAP transporter small transmembrane protein (probable substrate D-Ala-D-Ala);-0.42474339742930756;-0.38486020216033445;0.08062741442934396;0.10986151317704707;0.5346049106063546
HELO_4225;9.677340753440411;11.713948301516012;18.190811466436475;30.36634624802169;19.89405359444611;18.8704478376708;0.6692512933188247;1.4924267834814662;1.4113108027201136;2.6535314196687168;2.0743220953243235;1.0172943689895626;HELO_4225;TRAP transporter large transmembrane protein (probable substrate D-Ala-D-Ala);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS17755;G;;;;HELO_4225;TRAP transporter large transmembrane protein (probable substrate D-Ala-D-Ala);-0.25185974600097216;-0.050208672331702786;0.0724680243849889;-0.8960720070829122;-0.6442122610819401
HELO_4226;24.662851009712057;23.87025210982431;44.158149105932274;73.15915774409235;52.50926786710854;46.59372730499384;0.907761850959274;1.446191667655271;1.215079151228733;4.699589747609873;1.8000205225077284;4.214216051515727;ddpX;D-alanyl-D-alanine dipeptidase;COG2173;D-alanyl-D-alanine dipeptidase;DdpX;HELO_RS17760;M;ddpX; D-alanyl-D-alanine dipeptidase;3.4.13.22;ddpX;D-alanyl-D-alanine dipeptidase;0.045260323038203154;-0.0757850879762989;0.1690173459532449;-0.8910899883815233;-0.9363503114197265
HELO_4227;88.0829262884396;58.52753641158217;100.99360410062617;93.77276030554863;98.59897974160499;101.59927864011281;1.6145321639170769;2.1200753153800256;1.356383459068129;6.684998525370598;0.6329706595927245;1.7156179139070522;HELO_4227;TRAP transporter 4TM/12TM fusion protein;COG4666;TRAP-type uncharacterized transport system, fused permease components;;HELO_RS17770;R;;ddpX;;HELO_4227;TRAP transporter 4TM/12TM fusion protein;0.5815917613827333;-0.008541902293585757;-0.04281771861201644;-0.20379973245063;-0.7853914938333633
HELO_4228;152.14030805748817;99.07755349489503;186.54023876220802;179.498788838121;206.6880032183577;187.61312750571005;3.1677409170112476;4.669448280589072;6.676082130940216;10.052720185309562;8.853880097922191;7.817149875723101;HELO_4228;TRAP transporter substrate-binding protein;COG2358;TRAP-type uncharacterized transport system, periplasmic component;Imp;HELO_RS17775;R;;;;HELO_4228;TRAP transporter substrate-binding protein;0.6137356377631642;-0.008229916868867981;0.13898779217702817;-0.300576026772843;-0.9143116645360072
HELO_4229;14.30531121192709;11.48124897898588;19.15980838544086;22.040342249708278;28.06887303570439;20.78076106360622;0.5233957434183761;0.6341921186076331;0.7911641045115033;1.8551562867428646;0.3257701116114016;0.9114537775337617;HELO_4229;GFO family oxidoreductase;COG0673;Predicted dehydrogenase;MviM;HELO_RS17780;R;;;;HELO_4229;GFO family oxidoreductase;0.29427007068173916;-0.1115724391995423;0.41642077545145373;-0.5090219852694569;-0.803292055951196
HELO_4230;17.637636418088867;17.41657957784713;33.25773392120597;30.52543178248567;49.52051404204647;33.52615455910842;0.7931304402279235;0.4428972109000008;2.2242294477171836;1.8053900447578919;0.4079054994893778;3.1766711987904377;mmsA3;methylmalonate-semialdehyde dehydrogenase (CoA-acylating);COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS17785;I;mmsA3; methylmalonate-semialdehyde dehydrogenase (CoA-acylating);1.2.1.18,1.2.1.27;mmsA3;methylmalonate-semialdehyde dehydrogenase (CoA-acylating);0.01721377080296005;-0.011259935938329413;0.5491796593025224;-0.8894707468535064;-0.9066845176564664
HELO_4231;14.497140455721686;10.873813452074254;16.606112371613143;15.91473590350226;25.322494200882982;18.447161735059336;0.5727289652029198;0.3570785447945745;1.1311601830462734;0.13937053612538433;0.650202101574953;0.9731056620906532;iolE;inosose dehydratase;COG1082;Sugar phosphate isomerase/epimerase;YcjR;HELO_RS17790;G;iolE; inosose dehydratase;4.2.1.44;iolE;inosose dehydratase;0.3842186804534009;-0.14348323183627798;0.43673658601016996;-0.32755757996007073;-0.7117762604134716
HELO_4232;13.38833428407009;11.122791840936413;19.87611605890672;24.12983179697441;27.141130730225157;20.154110573114618;0.38618110846415254;0.426617351764804;0.840329222952945;1.8223571175461308;2.2013562448979;2.1626581180661275;iolD;3D-(3%2C5/4)-trihydroxycyclohexane-1%2C2-dione hydrolase;COG3962;TPP-dependent trihydroxycyclohexane-1,2-dione (THcHDO) dehydratase, myo-inositol metabolism;IolD;HELO_RS17795;G;iolD; 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase;3.7.1.22;iolD;3D-(3%2C5/4)-trihydroxycyclohexane-1%2C2-dione hydrolase;0.24717759788179805;-0.019084701071265364;0.4117422695311257;-0.5560384456000103;-0.8032160434818083
HELO_4233;10.198450780830372;9.18802301500212;15.150684935978264;23.76764990298969;23.540258794644725;15.207274341632752;0.8626717260737634;0.7804057662723489;0.9025025638127098;1.4874183146353332;1.350456495802724;1.05982330744733;iolC;5-dehydro-2-deoxygluconokinase / DUF2090 domain protein;COG3892;Myo-inositol catabolism protein LolC;IolC;HELO_RS17800;G;iolC; 5-dehydro-2-deoxygluconokinase / DUF2090 domain protein;2.7.1.92;iolC;5-dehydro-2-deoxygluconokinase / DUF2090 domain protein;0.13642503655844962;-0.005046136404183166;0.5985089773198728;-0.5333423256444583;-0.6697673622029079
HELO_4234;8.471585609663208;6.407921490285926;11.555853447244715;21.38728090304589;18.454356050429634;10.89718775772659;0.48630785101996254;0.5725540207016054;1.6618035982368673;2.1516583915935574;0.27759126866542394;0.8113172441385814;HELO_4234;xylose isomerase domain protein;COG3622;Hydroxypyruvate/dehydroerythronate isomerase, Hyi/OtnI family;Hyi;HELO_RS17805;G;;iolC;5.3.1.22;HELO_4234;xylose isomerase domain protein;0.35453715426230836;0.0777395035051156;0.7094726357316063;-0.3289427231308957;-0.683479877393204
HELO_4235;10.260290186647827;6.570280855216857;13.503689361852588;24.238595865140695;19.923776046325358;12.48167722348988;1.1480026212519319;0.41489344544319245;1.2288702269108818;1.6256916866921545;1.5077265793215249;0.9786134249953707;HELO_4235;ABC-type transport system ATP-binding protein;COG1129;ABC-type sugar transport system, ATPase component;MglA;HELO_RS17810;G;;;7.5.2.-;HELO_4235;ABC-type transport system ATP-binding protein;0.5728252774149158;0.1054199411156791;0.63414324364433;-0.25975598265603583;-0.8325812600709517
HELO_4236;7.888334896659376;7.04956636671472;12.364889417779926;21.632904454264892;22.86473242128099;12.270306006587646;0.9242787585376447;0.5274983157014823;1.2684522899656;2.2398565283467855;2.728579226969172;1.1540028924965797;HELO_4236;ABC-type transport system permease protein;COG1172;Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component;AraH;HELO_RS17815;G;;;;HELO_4236;ABC-type transport system permease protein;0.14300210916075207;0.010246261735851192;0.8466785216260195;-0.5782165578659169;-0.7212186670266689
HELO_4237;11.081885836683862;6.053455798879214;22.171630590320586;40.4438078286459;45.205607369093535;21.186912563210026;1.1914590356666552;0.482985076979157;0.8113138293206316;2.19046630757864;4.922315742421226;3.287369369145597;HELO_4237;ABC-type transport system periplasmic substrate-binding protein;COG1879;ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain;RbsB;HELO_RS17820;G;;;;HELO_4237;ABC-type transport system periplasmic substrate-binding protein;0.7764434838133445;0.06265064822160671;1.058359021088032;-0.8768632626322286;-1.653306746445573
HELO_4238;19.545518142036283;14.933095223697167;23.020715914853408;24.359096146244564;22.765816343053547;23.164536015116624;0.9284337305362668;0.14323290379759807;2.835016082211734;1.6228728543170032;2.451691595861976;3.6515507259615307;HELO_4238;RpiR family transcription regulator;COG1737;DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains;RpiR;HELO_RS17825;K;;;;HELO_4238;RpiR family transcription regulator;0.3667971570978219;-0.008612143893361512;-0.024003335454159114;-0.23406757913233633;-0.6008647362301582
HELO_4239;22.565600029430346;33.32227440011112;50.38662837307961;50.53533061655775;60.36221711760255;57.000181151042135;0.46435242589739717;0.12092960501453041;1.2091269177277575;3.6382834714995598;0.19508659190054428;3.748865638329963;idhA;inositol 2-dehydrogenase;COG0673;Predicted dehydrogenase;MviM;HELO_RS17830;R;idhA; inositol 2-dehydrogenase;1.1.1.18,1.1.1.369;idhA;inositol 2-dehydrogenase;-0.5424627417943357;-0.17466441038478386;0.08129320452824551;-1.2993749903416916;-0.7569122485473558
HELO_4240;21.896139194010203;30.790334704664932;45.833505791113936;41.8798732887096;55.31133254291598;47.073863519698506;0.9486050903100487;1.4485072506234815;2.33987248724102;5.368676786664875;2.6283094751824603;4.948035746865668;iolB;5-deoxy-glucuronate isomerase;COG3718;5-deoxy-D-glucuronate isomerase;IolB;HELO_RS17835;G;iolB; 5-deoxy-glucuronate isomerase;5.3.1.30;iolB;5-deoxy-glucuronate isomerase;-0.47348385810124416;-0.03771171508912907;0.22817253878030286;-1.0701484043572949;-0.5966645462560507
HELO_4241;129.27858119256817;149.34324691731027;94.8803575946021;153.69088781605544;14.932556751598318;100.6347370149491;1.1650199304176692;2.5425514809222283;4.3796031043441355;16.971790903398368;1.1780176055028895;3.6430872782369366;HELO_4241;UPF0721 family protein;;;;;;;;;HELO_4241;UPF0721 family protein;-0.20666015356286582;-0.08408638011240832;-2.6733438701495253;0.3582063382812368;0.5648664918441026
HELO_4242;2064.147976257919;1270.4732779246522;2608.728837692126;2706.5910640961997;84.6955409658559;2866.9621042074723;37.20327588702784;41.42975382638503;81.07292687617688;118.72436339566558;10.782630076592811;40.60664483656829;gapA1;glyceraldehyde 3-phosphate dehydrogenase;COG0057;Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase;GapA;HELO_RS17845;G;gapA1; glyceraldehyde 3-phosphate dehydrogenase;1.2.1.12;gapA1;glyceraldehyde 3-phosphate dehydrogenase;0.6997440185522183;-0.13612604890686342;-5.0646620130030895;-0.4737808008071287;-1.173524819359347
HELO_4243;190.91499247052823;136.71191818854496;578.4667025287085;563.1378817970507;22.922937247249838;662.4131881248594;8.01483044995372;8.520601436844041;21.251900765655616;38.40914909233416;0.545089073234051;44.498525100715284;pykA1;pyruvate kinase;COG0469;Pyruvate kinase;PykF;HELO_RS17850;G;pykA1; pyruvate kinase;2.7.1.40;pykA1;pyruvate kinase;0.47881399782684575;-0.1951819289537564;-4.793441253078963;-1.7894402722288643;-2.26825427005571
HELO_4244;427.0298576805717;304.8995440964499;749.9879561030374;656.7873371223351;62.14736601492888;847.1784980364732;29.862609834495874;15.192594698137764;17.671887042435728;64.60712347317028;7.765713482648343;44.275003644239526;mgsA;methylglyoxal synthase;COG1803;Methylglyoxal synthase;MgsA;HELO_RS17855;G;mgsA; methylglyoxal synthase;4.2.3.3;mgsA;methylglyoxal synthase;0.4846534801242868;-0.17557813915000686;-3.747573446899443;-0.9866564731200391;-1.471309953244326
HELO_4245;273.54221348623054;195.29517279503037;945.7100918632915;741.6620213490642;77.91691080183477;984.8787446317648;20.91926062181204;14.64355113211562;68.74817388601736;43.54134890403212;5.271597116312067;91.65005093011588;pgi1;glucose-6-phosphate isomerase;;;;;;;;;pgi1;glucose-6-phosphate isomerase;0.48400329930615005;-0.05848751608432323;-3.6430038292566023;-1.8443822228959146;-2.3283855222020646
HELO_4246;33.64955554848617;25.637873586679074;20.08440490951439;25.523328677642628;42.71503251338837;26.871932696304558;2.8152393916980762;0.6913017286722964;3.203226055999562;2.1360429810926456;3.7315876861678854;1.609790022383567;crcB2;probable fluoride ion transport protein CrcB;COG0239;Fluoride ion exporter CrcB/FEX, affects chromosome condensation;CrcB;HELO_RS17865;DP;crcB2; probable fluoride ion transport protein CrcB;;crcB2;probable fluoride ion transport protein CrcB;0.3793579255291615;-0.402636742031957;0.6493164267107296;0.314023801653998;-0.06533412387516346
HELO_4247;51.49102090529479;42.70616191894941;58.8891148591103;56.7392977070883;73.3305878319397;49.1481898288103;7.195198156403388;3.9350974802179515;11.175006013342225;15.161442854013844;6.7809457591473805;5.037633623236317;crcB1;probable fluoride ion transport protein CrcB;COG0239;Fluoride ion exporter CrcB/FEX, affects chromosome condensation;CrcB;HELO_RS17870;DP;crcB1; probable fluoride ion transport protein CrcB;;crcB1;probable fluoride ion transport protein CrcB;0.26423396438742586;0.256096184307963;0.5677583917711884;0.06587303138111622;-0.19836093300630964
HELO_4248;131.04867161969682;120.69725485703789;175.1845430507357;165.50165134756;196.5961406747963;181.31367394695417;9.241160227548049;2.113043020734819;9.944389227158101;2.4962229643311487;15.561647868236454;3.190176522088761;mscS2;mechanosensitive ion channel MscS;COG0668;Small-conductance mechanosensitive channel;MscS;HELO_RS17875;M;mscS2; mechanosensitive ion channel MscS;;mscS2;mechanosensitive ion channel MscS;0.11777316305293617;-0.04933541101078376;0.11613199847561351;-0.46535298251148394;-0.5831261455644201
HELO_4249;31.25419259195495;33.02050823874803;38.71847914381498;24.18944024575875;15.511580925320516;38.86094864983286;2.1531774378125994;0.49439275840226055;5.5930676046059435;1.7564472890577112;2.838553330450651;1.5449775340810807;HELO_4249;homolog to outer membrane protein OprM;COG1538;Outer membrane protein TolC;TolC;HELO_RS17880;M;;mscS2;;HELO_4249;homolog to outer membrane protein OprM;-0.07691799103933139;-0.005165663415819921;-1.2714977854542564;-0.30548934243828807;-0.22857135139895668
HELO_4250;28.471093500499148;49.13801065394794;35.7468699052125;22.012584336152315;15.526020668009759;37.44001171517619;2.61678755589576;4.096886178847256;3.3586292348981965;0.4522718579835993;1.3896145835545568;1.9318749444308512;macB;ABC-type transport system ATP-binding/permease protein (probable substrate macrolide);COG1136;ABC-type lipoprotein export system, ATPase component;LolD;HELO_RS17885;M;macB; ABC-type transport system ATP-binding/permease protein (probable substrate macrolide);7.6.2.-;macB;ABC-type transport system ATP-binding/permease protein (probable substrate macrolide);-0.7666041634561189;-0.06498740923498314;-1.2178693986336224;-0.3833081843360704;0.38329597912004854
HELO_4251;49.42969968908499;85.30997589945979;72.94498845818548;49.685047054464285;36.24781224308807;76.6823419669157;2.775317230322506;2.8291502732010056;5.469576979633997;1.365904034687115;3.1372788612224287;3.241273087423959;macA;ABC-type transport system MFP component (probable substrate macrolide);COG0845;Multidrug efflux pump subunit AcrA (membrane-fusion protein);AcrA;HELO_RS17890;VM;macA; ABC-type transport system MFP component (probable substrate macrolide);;macA;ABC-type transport system MFP component (probable substrate macrolide);-0.7752536849381331;-0.07113432223904859;-1.0604310046646743;-0.6233130617636125;0.15194062317452062
HELO_4252;451.5981294407584;392.5784762870483;469.1748252918319;557.4014844783575;648.2595787047838;477.0742036179268;1.4287788556207075;8.371125905156084;8.985181657628303;31.62310254215328;13.539255464164098;11.70354040225492;HELO_4252;TPR domain protein;COG3071;Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY);HemYx;HELO_RS17895;S;;macA;;HELO_4252;TPR domain protein;0.2015792961979539;-0.024037267059730638;0.44156083206050845;-0.07900393942572315;-0.28058323562367704
HELO_4253;536.1443461863595;392.6996043563995;531.5275419549005;578.3494870401101;660.7062450928074;514.7646944491236;24.722352227363075;11.947174663520757;35.64560849547625;56.998673962256895;50.159547134923514;31.11977160441467;hemX;HemX family protein;COG2959;Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis HemX, COG0755, no evidence of involvement in heme biosynthesis);HemX;HELO_RS17900;R;hemX; HemX family protein;2.1.1.107;hemX;HemX family protein;0.4482145714231045;0.0461431224998865;0.35947787562244926;0.058596814147581;-0.3896177572755235
HELO_4254;174.61199537188966;141.19796747070336;112.04520227614664;104.11669544221446;114.38213253760618;114.81589305516268;8.56243848816577;4.829392702117137;5.131810839663531;8.06256039084296;10.138001912977096;14.156385146489963;hemD;uroporphyrinogen-III synthase;COG1587;Uroporphyrinogen-III synthase;HemD;HELO_RS17905;H;hemD; uroporphyrinogen-III synthase;4.2.1.75;hemD;uroporphyrinogen-III synthase;0.3044905494086896;-0.03493347914982525;-0.00541341025940234;0.6005581496518042;0.2960676002431146
HELO_4255;239.09490451326732;180.19790608726035;297.182581583786;265.42771525724424;332.7920735990887;310.3831117414065;11.214760282413941;9.905858867065977;34.03880159133595;12.784468887192325;25.759840192951856;16.219057104591244;hemC;porphobilinogen deaminase;COG0181;Porphobilinogen deaminase;HemC;HELO_RS17910;H;hemC; porphobilinogen deaminase;2.5.1.61;hemC;porphobilinogen deaminase;0.4060385020830495;-0.06249471547924301;0.10025899597667376;-0.3750859142793246;-0.7811244163623741
HELO_4256;346.33588986960314;316.6191431949602;432.0074036076533;358.32361563539394;398.7164162542768;411.34513657556664;19.700334309138103;1.6119485230406236;4.757315617475348;16.656167965050788;26.192133680744153;14.368066628227606;argH;argininosuccinate lyase;COG0165;Argininosuccinate lyase;ArgH;HELO_RS17915;E;argH; argininosuccinate lyase;4.3.2.1;argH;argininosuccinate lyase;0.12903362301077337;0.07053930078279613;-0.044875566633375996;-0.24752090108088787;-0.37655452409166124
HELO_4257;373.969682393363;314.8599444969699;11.534237001143582;10.004255546615731;13.840891892165537;15.314498344250273;50.44528514743322;25.57042489624046;3.0064861585142113;4.919335782846261;10.169385748226993;2.7770693690828967;HELO_4257;uncharacterized protein;;;;;;;;;HELO_4257;uncharacterized protein;0.24748895882540545;-0.3802804491615004;-0.13657683045328106;4.522547421713086;4.275058462887681
HELO_4258;370.1507599474947;323.10756117359193;388.6818942340422;353.90339880145024;371.7088852075203;394.7221998827056;28.476072534780997;10.500132380792406;9.844550131473872;12.22515215760106;6.4863719728313285;11.803360068098229;lysA;diaminopimelate decarboxylase;COG0019;Diaminopimelate decarboxylase;LysA;HELO_RS17925;E;lysA; diaminopimelate decarboxylase;4.1.1.20;lysA;diaminopimelate decarboxylase;0.19553264484140698;-0.022191101075954123;-0.08643878962933549;-0.09248267946250088;-0.28801532430390786
HELO_4259;345.9109809762199;296.44767032156034;326.31844460157174;311.0670447150505;331.64715979204124;322.1818706683123;13.70543860505492;7.406368656700552;21.48178461237449;16.42072485898217;5.867756672874403;10.629601208953318;dapF;diaminopimelate epimerase;COG0253;Diaminopimelate epimerase;DapF;HELO_RS17930;E;dapF; diaminopimelate epimerase;5.1.1.7;dapF;diaminopimelate epimerase;0.2219296290037498;0.018348631055919995;0.04164644535762996;0.10221923742085615;-0.11971039158289365
HELO_4260;262.27699976884935;223.76189222198613;232.3005431115498;221.0928707617702;271.659577313709;233.11265825996438;11.427119131024986;3.0877162533327267;3.146440285994176;2.390782947385039;24.2503991867048;8.656763491604933;HELO_4260;DUF484 family protein;COG3159;Uncharacterized conserved protein YigA, DUF484 family;YigA;HELO_RS17935;S;;dapF;;HELO_4260;DUF484 family protein;0.22818403991400427;-0.005013275931388783;0.21989789000677895;0.1693785493423121;-0.058805490571692154
HELO_4261;90.14268205244004;72.1751395988759;100.15275759382864;107.72967709325336;109.62808878372647;96.15250878099657;5.784416559139512;8.146863609885088;14.392043672079732;6.422588501111879;5.171955504688899;5.278590734270115;xerC;tyrosine recombinase XerC;COG4973;Site-specific recombinase XerC;XerC;HELO_RS17940;L;xerC; tyrosine recombinase XerC;;xerC;tyrosine recombinase XerC;0.316773232402638;0.058212494425865735;0.18739458012980403;-0.09212442585925196;-0.40889765826188995
HELO_4262;156.73202400590262;114.43451751381303;210.095433444002;196.01169696013986;214.1644849864127;196.82901608168928;7.467016258453559;18.584822204775467;4.169357834383784;3.018513381091691;17.44985837109853;24.172555932042236;engB;probable GTP-binding protein EngB;COG0218;GTP-binding protein EngB required for normal cell division;EngB;HELO_RS17950;D;engB; probable GTP-binding protein EngB;;engB;probable GTP-binding protein EngB;0.45040091053000797;0.09364132434555472;0.12118592120127403;-0.3267784480934939;-0.7771793586235018
HELO_4263;164.36142600004942;91.89640757539917;136.6571628762803;171.79353293885163;156.5936067239475;138.89971943627796;2.658894224694411;2.196125755301573;7.564629512278204;5.095558341068321;11.836611048960155;1.3033166682498327;HELO_4263;cytochrome c4;COG2863;Cytochrome c553;CytC553;HELO_RS17955;C;;engB;;HELO_4263;cytochrome c4;0.8319280231504944;-0.023313387907597516;0.17181593932467187;0.24122966582693284;-0.5906983573235616
HELO_4264;745.8081557342538;140.39439608557774;392.31518090014606;299.4117486610913;339.05720742278805;363.96974836814314;18.643569951693422;4.32714671611213;24.40929831972542;8.298237382668283;35.006820502195744;11.800985777505892;dsbA;thiol:disulfide interchange protein DsbA;COG2761;Predicted dithiol-disulfide isomerase, DsbA/YjbH family (virulence, stress resistance);FrnE;HELO_RS17960;O;dsbA; thiol:disulfide interchange protein DsbA;1.8.4.15;dsbA;thiol:disulfide interchange protein DsbA;2.4010127403797785;0.10790898470923516;-0.10199941710065197;1.03296079625291;-1.3680519441268686
HELO_4265;420.96728113143246;82.00766828692299;140.4145668574662;134.54440978823212;133.9242820360098;138.41841891493104;12.693889036727791;5.729794062339652;4.306766219539744;3.6927012464514877;10.835904060193712;7.773527974506995;HELO_4265;YbhP family protein;COG3568;Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family;ElsH;HELO_RS17965;R;;dsbA;;HELO_4265;YbhP family protein;2.3458146137515596;0.020509565358914905;-0.04727116142679666;1.5977099664811867;-0.748104647270373
HELO_4266;46.25343614702319;50.879833416099274;92.01290276791474;70.82936032358164;82.11638908081305;105.11116350474492;3.0505787984251107;5.098584438146711;3.243729193728091;2.523721173849289;9.534607057557261;2.504978635261169;HELO_4266;TRAP transporter small transmembrane protein (probable substrate pyruvate/small keto acid);COG4665;TRAP-type mannitol/chloroaromatic compound transport system, small permease component;FcbT2;HELO_RS17970;Q;;;;HELO_4266;TRAP transporter small transmembrane protein (probable substrate pyruvate/small keto acid);-0.13475460498489955;-0.1900736779022587;-0.35237155996815517;-1.1670852967604546;-1.032330691775555
HELO_4267;58.05548439712962;69.60219194239254;119.94116446851187;70.44151193878109;111.6690020450182;131.99704567005708;3.6272739582056857;2.3065936238797247;6.125909477669861;1.4333167026220441;3.8521374207635617;8.755564584943933;HELO_4267;TRAP transporter large transmembrane protein (probable substrate pyruvate/small keto acid);COG4664;TRAP-type mannitol/chloroaromatic compound transport system, large permease component;FcbT3;HELO_RS17975;Q;;;;HELO_4267;TRAP transporter large transmembrane protein (probable substrate pyruvate/small keto acid);-0.257641927809626;-0.13708882377810827;-0.23930354881289606;-1.1712512468239114;-0.9136093190142853
HELO_4268;102.0106141839711;161.4904536103555;940.3023111978546;620.2501463100332;980.1076261060526;1115.529033437643;3.256366474363638;5.848323959853773;87.40606509368345;13.404215052884537;46.43851786492483;191.9206078394987;HELO_4268;TRAP transporter substrate-binding protein (probable substrate pyruvate/small keto acid);COG4663;TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component;FcbT1;HELO_RS17980;Q;;;;HELO_4268;TRAP transporter substrate-binding protein (probable substrate pyruvate/small keto acid);-0.6575619616783142;-0.24629072414777475;-0.18653745465295657;-3.438155861416627;-2.780593899738313
HELO_4269;227.4914328146733;172.9842841057845;339.10778361064257;290.8254950004758;319.9163005138573;358.37384526486466;6.437316125795815;2.739596590441526;26.113728650620555;1.4549400313499716;17.58565389228782;15.82912951366062;thiD;hydroxymethylpyrimidine/phosphomethylpyrimidine kinase;COG0351;Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase;ThiD;HELO_RS17985;H;thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase;2.7.1.49,2.7.4.7;thiD;hydroxymethylpyrimidine/phosphomethylpyrimidine kinase;0.39318307888751836;-0.0794933917691445;-0.16328834405975812;-0.6533453422195663;-1.0465284211070847
HELO_4270;94.70847106925923;52.2893491748136;104.23822720297251;107.01866535684881;106.16844546845972;109.02808610352804;4.9315382301648505;1.5360815062428246;8.113675684993177;0.8602455357370578;10.054734149507588;4.2837773400284345;HELO_4270;UspA domain protein;COG0589;Nucleotide-binding universal stress protein,  UspA family;UspA;HELO_RS17990;T;;thiD;;HELO_4270;UspA domain protein;0.8447994084744659;-0.06421298666635966;-0.03799165432801832;-0.2011533103853873;-1.0459527188598532
HELO_4271;46.397675472807954;23.419647093089523;21.53777238532018;20.994197027104544;21.23258070688729;19.957378596754094;1.2744285170486427;3.9658585866437543;2.6539822479961868;1.0648956813819461;1.0757612837296315;2.3783860330798126;dtd;D-aminoacyl-tRNA deacylase;COG1490;D-aminoacyl-tRNA deacylase;Dtd;HELO_RS17995;J;dtd; D-aminoacyl-tRNA deacylase;3.1.1.96;dtd;D-aminoacyl-tRNA deacylase;0.9567739556828299;0.10488665565402666;0.08521715068620939;1.1773580345499184;0.22058407886708853
HELO_4272;4.512858889466345;5.178768808760718;8.799390495580786;7.900176366814395;12.600366591500453;9.784826384658281;0.1673873409877326;0.3611473909516201;0.6558203101052632;0.7805560115873138;0.42814184073153216;1.7385266943505948;HELO_4272;NCS2 family transport protein;COG2233;Xanthine/uracil permease;UraA;HELO_RS18000;F;;dtd;;HELO_4272;NCS2 family transport protein;-0.16451871928259054;-0.13823902791831566;0.3346425871485317;-0.9681303731162427;-0.8036116538336522
HELO_4273;140.52444466986657;136.44677998319617;183.82345556639402;184.6085895767243;166.5160868168721;170.82073998393972;2.6348350480261287;1.0396120084221552;13.883603972926613;12.035701223995288;11.397829457587976;1.3957858255965325;yheS;ABC-type transport system ATP-binding protein YheS;COG0488;ATPase components of ABC transporters with duplicated ATPase domains;Uup;HELO_RS18005;R;yheS; ABC-type transport system ATP-binding protein YheS;;yheS;ABC-type transport system ATP-binding protein YheS;0.042178153961650366;0.10524366731918722;-0.036604544172202935;-0.2798529278723798;-0.3220310818340302
HELO_4274;606.1689663619001;2233.062365236235;0.2853684443160147;0.1925139331363114;3490.7194636013796;3230.114724377245;42.50181609611887;169.18627946069543;0.05739681141182394;0.21955018923205916;87.80272624839527;630.1354500944593;teaA;TRAP transporter substrate-binding protein TeaA (substrate ectoine);COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS18015;G;teaA; TRAP transporter substrate-binding protein TeaA (substrate ectoine);;teaA;TRAP transporter substrate-binding protein TeaA (substrate ectoine);-1.8794995014310452;-11.295634300807853;0.11190567665811813;-2.4118620173503906;-0.5323625159193455
HELO_4275;173.592937376275;849.0706337028773;0.0;0.0;753.8727606089111;810.3780677777023;7.028043676011459;28.3504625936404;0.0;0.0;88.82490121395114;32.62025708407292;teaB;TRAP transporter small transmembrane protein TeaB (substrate ectoine);COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS18020;G;teaB; TRAP transporter small transmembrane protein TeaB (substrate ectoine);;teaB;TRAP transporter small transmembrane protein TeaB (substrate ectoine);-2.2835875216970534;-9.664230495602139;-0.10414081782480089;-2.2163791054987074;0.06720841619834594
HELO_4276;42.77506656885722;153.4790773418443;0.0;0.0;203.74737238817355;208.88144763376044;1.1460515634267876;5.924641575599928;0.0;0.0;16.120431014392395;13.514348747482586;teaC;TRAP transporter large transmembrane protein TeaC (substrate ectoine);COG1593;TRAP-type C4-dicarboxylate transport system, large permease component;DctQ;HELO_RS18025;G;teaC; TRAP transporter large transmembrane protein TeaC (substrate ectoine);;teaC;TRAP transporter large transmembrane protein TeaC (substrate ectoine);-1.819230174949972;-7.713430835729741;-0.03572970870107017;-2.261393368271789;-0.4421631933218171
HELO_4277;67.00823036838601;180.71528917555227;927.8322226358915;664.2676516455498;175.08695461884312;157.34273747161336;4.583881424634754;5.621894118760067;34.19692625402226;44.357854158105766;18.06328797245426;5.844551126342275;teaD;UspA domain transport protein regulator TeaD;COG0589;Nucleotide-binding universal stress protein,  UspA family;UspA;HELO_RS18030;T;teaD; UspA domain transport protein regulator TeaD;;teaD;UspA domain transport protein regulator TeaD;-1.4178985530127628;2.5523673239972604;0.15323733282555985;-1.2192694411544593;0.19862911185830345
HELO_4278;762.2068101196825;522.0071650488175;1231.4222889987386;815.1387247580702;773.5536219472871;829.2830759552409;17.700227706262307;19.34051486182639;53.72737429607002;17.216234979252814;76.76804914853993;25.584824883937532;HELO_4278;FKBP-type peptidyl-prolyl cis-trans isomerase;COG0545;FKBP-type peptidyl-prolyl cis-trans isomerase;FkpA;HELO_RS18035;O;;teaD;5.2.1.8;HELO_4278;FKBP-type peptidyl-prolyl cis-trans isomerase;0.5452433334988598;0.5698214830440218;-0.10023817195519058;-0.12152924684355604;-0.6667725803424158
HELO_4279;22.762013226014854;7.1251914760048045;16.85419320755196;17.46326830409839;16.166711324825645;17.048836704064993;2.8770584527439476;0.6082772784961048;2.393860361483052;0.9316442306848948;1.4209907506300798;3.0604063346154247;HELO_4279;SCO1 family protein;COG1999;Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family;Sco1;HELO_RS18040;O;;;;HELO_4279;SCO1 family protein;1.5481833563212533;-0.01564291142158769;-0.07229216988072906;0.3967512184694266;-1.1514321378518266
HELO_4280;26.442375385041498;19.7744270227916;24.475588120777974;26.077105915777462;22.157204108328468;24.56071657113809;1.0811538978027566;1.7556531305728535;3.7876873837413263;0.8603433301024722;3.9779435961405;0.8044517832013887;HELO_4280;AEC family transport protein;COG0679;Predicted permease, AEC (auxin efflux carrier) family;YfdV;HELO_RS18045;R;;;;HELO_4280;AEC family transport protein;0.40159667845089153;-0.0048128291346110075;-0.14246720183567874;0.10247708370244712;-0.2991195947484444
HELO_4281;55.02557236788652;25.813352621472433;44.63633241169297;52.76435998251591;41.33452592384759;37.89023405700221;4.166057145143604;2.333215794610721;8.092858252625962;4.52756886213037;5.868283494942515;1.664481138926315;HELO_4281;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS18050;K;;;;HELO_4281;LysR family transcription regulator;1.063133863934782;0.23077493581053599;0.12242681585803261;0.5266775651427258;-0.5364562987920563
HELO_4282;14.33060267625644;6.543198384032718;11.361834400994818;12.931084601510932;10.684721417695428;11.267186796215228;1.7981183909113978;0.21932193815776224;0.4534781710976225;0.6360719045431255;1.4710177851271728;1.3571141030095992;HELO_4282;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS18055;GER;;;;HELO_4282;DMT superfamily transport protein;1.0231661392848115;0.01108840673314937;-0.07018109883399859;0.32160997607655606;-0.7015561632082554
HELO_4283;231.27651261638115;198.72296663154157;235.17861219660412;228.5004892103116;291.8881722553001;227.2303623742698;3.0887316315758744;5.520327689324558;17.452127590751722;12.421558155300104;9.074405391616484;10.777533381757458;trmB;tRNA (guanine-N(7)-)-methyltransferase TrmB;COG0220;tRNA G46 N7-methylase TrmB;TrmB;HELO_RS18060;J;trmB; tRNA (guanine-N(7)-)-methyltransferase TrmB;2.1.1.33;trmB;tRNA (guanine-N(7)-)-methyltransferase TrmB;0.2178430374453475;0.049387591699368016;0.3598592020986402;0.02535254705547807;-0.19249049038986943
HELO_4284;366.48649901128925;367.7239457968811;331.1117720955311;390.70974933181816;436.40210257321047;337.97552463857477;23.45661963190631;21.065746241264957;7.4075360589873;15.389694888547453;11.687667902902646;14.942502363337809;thiG;thiazole synthase;COG2022;Thiazole synthase ThiGH, ThiG subunit (thiamin biosynthesis);ThiG;HELO_RS18065;H;thiG; thiazole synthase;2.8.1.10;thiG;thiazole synthase;-0.004849863336678695;-0.029512247102584155;0.3677790464902593;0.11651013924754317;0.12136000258422186
HELO_4285;126.51393480444682;147.7326792656098;387.77577829687897;417.55105598158997;487.1737739953685;427.751993340869;22.294001417065303;24.206712096530133;8.611424143589149;19.559215387250056;23.575407292678086;2.0773204844483906;HELO_4285;ThiS domain protein;COG2104;Sulfur carrier protein ThiS (thiamine biosynthesis);ThiS;HELO_RS18070;H;;thiG;;HELO_4285;ThiS domain protein;-0.22206675413331833;-0.14120504040036685;0.18725141311794147;-1.7494884642982722;-1.5274217101649539
HELO_4286;69.38927811477633;40.4270532307146;128.12827700084404;128.91682021494157;121.07734167943148;129.81356350879022;6.38633457091665;5.861454679568695;12.976816903852656;8.041066528818755;16.827608291485433;7.004303743851094;HELO_4286;UPF0382 family protein;COG2363;Uncharacterized membrane protein YgdD, TMEM256/DUF423 family;YgdD;HELO_RS18075;S;;;;HELO_4286;UPF0382 family protein;0.7647824875121616;-0.018707173494357576;-0.0997166836579817;-0.8940845400792039;-1.6588670275913655
HELO_4287;156.75187682988238;151.98890088948795;183.71358348602428;165.45537646306084;582.5253229938896;183.9376301671582;9.102759772095194;7.881396954524504;8.007332748331308;14.413501703700936;27.64479404626435;13.581399761368846;HELO_4287;thioesterase domain protein;COG2050;Acyl-CoA thioesterase PaaI, contains HGG motif;PaaI;HELO_RS18080;Q;;;;HELO_4287;thioesterase domain protein;0.04423017816502561;-0.0017488435770900423;1.6577564584473343;-0.2293816372879789;-0.2736118154530045
HELO_4288;163.9457412705692;207.4545357450628;260.1950333860473;222.0700200843139;1100.4532487908737;264.9589268996004;9.52456635096673;6.353743691243197;8.988586821964642;4.838163361353118;26.470807492284784;27.068211092249197;glcB;malate synthase;COG2225;Malate synthase;AceB;HELO_RS18085;C;glcB; malate synthase;2.3.3.9;glcB;malate synthase;-0.3377412344890951;-0.026075997413572694;2.0501328942350536;-0.6892119322843682;-0.35147069779527307
HELO_4289;155.01523664259526;88.66536950260843;144.00682398242725;183.13707395218736;145.96481549142072;136.20824087990442;2.6935076920078247;3.3121510199547504;13.522651336388611;5.414567118226343;6.317684874350695;8.124127288338798;HELO_4289;alpha/beta hydrolase fold protein;COG2267;Lysophospholipase, alpha-beta hydrolase superfamily;PldB;HELO_RS18090;I;;glcB;;HELO_4289;alpha/beta hydrolase fold protein;0.7990641302227663;0.07975366069584933;0.09910367011167764;0.18531979737960835;-0.613744332843158
HELO_4290;195.42754222294744;29.389896177073073;112.08398375920899;139.59392906022424;85.87559594904376;109.67100601300224;2.4452707222939227;1.945788977693606;13.021684174945786;12.8792888311183;7.84428359086863;22.110635514515423;HELO_4290;uncharacterized protein;COG2378;Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains;YobV;HELO_RS18100;K;;;;HELO_4290;uncharacterized protein;2.692333581102642;0.031117303704381705;-0.3492544347340685;0.8277199231126833;-1.8646136579899588
HELO_4291;103.34146212429756;57.31763755322685;172.67019286408996;147.15501047345603;142.69419494762096;154.40667838517925;7.085438852461615;0.9773929071866815;17.376793005381547;6.276374924209979;19.596136759109505;5.751906442041838;HELO_4291;PagP domain protein;;;;;;;;;HELO_4291;PagP domain protein;0.8393083725281398;0.1603016616577495;-0.11304672285278006;-0.574735947953144;-1.4140443204812838
HELO_4292;106.18153512755832;98.82338235836185;100.84337944592721;141.17954759271137;115.5200805586872;105.47178889696168;4.104370013234356;6.564814818574183;4.910655113578599;6.4777003184279955;5.125818812963445;4.262693417650593;HELO_4292;BCC family transport protein;COG1292;Choline-glycine betaine transporter;BetT;HELO_RS18110;M;;;;HELO_4292;BCC family transport protein;0.10260669134565514;-0.06411902225790556;0.13010738400099697;0.009585164550257375;-0.09302152679539777
HELO_4293;111.81159254642445;134.16268367875395;123.62235145158536;117.10516751319699;111.0455279759049;114.59345098585855;5.910938437490949;3.4636048251066387;3.0531648114851193;5.516718654216986;7.85250018954391;9.154237219459187;HELO_4293;ABC-type transport system ATP-binding protein;COG1121;ABC-type Mn2+/Zn2+ transport system, ATPase component;ZnuC;HELO_RS18120;P;;;;HELO_4293;ABC-type transport system ATP-binding protein;-0.26078157381707;0.10850318050729513;-0.04497459508601942;-0.03514433638363723;0.22563723743343278
HELO_4294;41.796546208846586;55.28026754208965;31.66161668131669;33.19658277048502;31.51503501893373;32.786367963344475;1.860996773929099;1.8912600602472387;6.452625834067482;1.4320654735284777;2.7609172606370183;3.3467068455709668;HELO_4294;ABC-type transport system permease protein;COG1108;ABC-type Mn2+/Zn2+ transport system, permease component;ZnuB;HELO_RS18125;P;;;;HELO_4294;ABC-type transport system permease protein;-0.3951348146658331;-0.048845065994077785;-0.0553342914583963;0.34105310309985715;0.7361879177656903
HELO_4295;53.576270016692064;79.74412819049245;86.40676113700992;79.27982704753283;89.80951880704772;87.76067797658537;3.2478547783134304;2.273562329348687;3.5651669683019667;2.341861090142876;1.281890789966828;6.172090020134323;HELO_4295;ABC-type transport system periplasmic substrate-binding protein;COG0803;ABC-type Zn uptake system ZnuABC, Zn-binding component ZnuA;ZnuA;HELO_RS18130;P;;;;HELO_4295;ABC-type transport system periplasmic substrate-binding protein;-0.5650835512823607;-0.02217580704641442;0.032922843924184875;-0.7016468894167955;-0.1365633381344349
HELO_4296;42.15805648729943;48.068804070981905;36.48295684955357;42.68209278526908;44.43643503705467;37.494713037877084;2.9728993344589063;2.263849759240786;1.1065753385075696;3.477065542697053;4.1838289573543905;4.728667802343038;HELO_4296;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS18135;K;;;;HELO_4296;LysR family transcription regulator;-0.18517621155463715;-0.03842555125977398;0.2391893287925102;0.1649695822125956;0.35014579376723276
HELO_4297;14.335912403376824;17.220386912212764;5.425243701490871;5.605839484804945;5.51572628923818;5.717208691681722;2.4559400024902716;0.13920950277728117;1.69030446911815;1.688440583709847;0.680384235167069;1.6718494627574634;HELO_4297;DoxX domain protein;;;;;;;;;HELO_4297;DoxX domain protein;-0.24863959360977894;-0.0641106765969357;-0.043935850750526306;1.190980244986668;1.439619838596447
HELO_4298;11.686945142769176;12.70428375339153;5.432336030295686;4.976199451469155;7.9343819157647415;6.067475015103173;0.12015019209615999;2.3167032916645436;0.9718517997650927;0.49323873350158653;0.6468213081160648;0.9147694593965876;HELO_4298;DOPA dioxygenase family protein;COG3384;Aromatic ring-opening dioxygenase, catalytic subunit, LigB family;LigB;HELO_RS18145;Q;;;1.13.11.-;HELO_4298;DOPA dioxygenase family protein;-0.11128220036894998;-0.13585210184859475;0.3381730486211536;0.8440779451570628;0.9553601455260128
HELO_4299;105.81585748197817;104.07877997638695;64.61774638243973;90.88606820970783;30.470868198477632;45.252419679562315;11.441056060320319;10.145556669497392;9.33289617202904;38.1730440561407;5.181437259739596;7.712190385586824;gloA;glyoxalase;COG0346;Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family;GloA;HELO_RS18150;Q;gloA; glyoxalase;4.4.1.5;gloA;glyoxalase;0.02365448484294852;0.5045572041700499;-0.5555118623554085;1.207525093210279;1.1838706083673305
HELO_4300;128.21197899967805;34.803165587465465;139.47097728470885;183.15279696720543;174.9977969823769;131.8199760465336;9.600692545017864;3.225601722923386;21.303559709533335;9.821810443859189;20.64892711058499;3.2725267083673577;HELO_4300;NlpC domain protein;COG0791;Cell wall-associated hydrolase, NlpC_P60 family;NlpC;HELO_RS18160;M;;;3.4.-.-;HELO_4300;NlpC domain protein;1.851580769615511;0.08079994245195543;0.4060852268339552;-0.0397323177144413;-1.8913130873299524
HELO_4301;1011.2917948221881;430.2594562571791;1362.370130723387;865.9010433878893;1219.2923754317746;1376.7496965223818;65.49922113815894;11.769785022959967;51.127652607631155;4.856088110067493;53.562846849939774;179.89997609393654;HELO_4301;peroxiredoxin;COG0450;Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin);AhpC;HELO_RS18165;V;;;1.11.1.24;HELO_4301;peroxiredoxin;1.2309972129499531;-0.015136528044802589;-0.1750869582795076;-0.44468860012156597;-1.675685813071519
HELO_4302;241.98115585035134;173.5749200230616;205.57167300248943;161.6749542865532;182.9065098277205;216.8193130222378;5.477585431576371;0.31884517644666005;10.575933968358994;4.206476135325007;9.25105156864398;6.469488435721643;thiM;hydroxyethylthiazole kinase;COG2145;Hydroxyethylthiazole kinase, sugar kinase family;ThiM;HELO_RS18170;H;thiM; hydroxyethylthiazole kinase;2.7.1.50;thiM;hydroxyethylthiazole kinase;0.4769981196737847;-0.07648944453983653;-0.24415932833617404;0.15771255469868795;-0.31928556497509675
HELO_4303;181.57777568612798;82.13253500633714;161.2997548924504;148.13546093965468;161.67912185946562;172.17047745854225;8.38071136204644;4.532953916367967;9.862156568243783;8.31822137206315;10.18495089592288;3.724767995938286;thiE;thiamine-phosphate synthase;COG0352;Thiamine monophosphate synthase;ThiE;HELO_RS18175;H;thiE; thiamine-phosphate synthase;2.5.1.3;thiE;thiamine-phosphate synthase;1.1350260534648307;-0.09353217561668181;-0.09016388844631518;0.07631816696167881;-1.0587078865031518
HELO_4304;55.29889672201574;43.140878902205806;53.06593146802965;53.775292252562394;43.281693854637886;51.1275786700586;1.171350869565845;1.4554472196574182;2.587886470436821;0.7481693185229561;2.6448226162302166;5.559704337664266;HELO_4304;DMT superfamily transport protein;COG0697;Permease of the drug/metabolite transporter (DMT) superfamily;RhaT;HELO_RS18180;GER;;thiE;;HELO_4304;DMT superfamily transport protein;0.35099129454757794;0.05267294762073682;-0.2353364393356161;0.11105980218502864;-0.2399314923625493
HELO_4305;511.6566763915528;172.00366190043715;267.1479662882898;324.48834055507785;277.9703469659128;260.2892266369608;6.509341710058859;3.5869802718232235;15.010009011856107;8.386493497823043;17.229341674891877;12.052977778222775;dacA2;D-alanyl-D-alanine carboxypeptidase DacA;COG1686;D-alanyl-D-alanine carboxypeptidase;DacC;HELO_RS18185;M;dacA2; D-alanyl-D-alanine carboxypeptidase DacA;3.4.16.4;dacA2;D-alanyl-D-alanine carboxypeptidase DacA;1.5671904084197816;0.03738167027297479;0.09446413823611088;0.972345342249529;-0.5948450661702527
HELO_4306;80.70893939045463;28.990153555255223;41.980133026838466;45.53974076781589;47.5363468287839;46.38931875269259;7.731972915669403;1.4793006580604304;3.3852559205030257;1.3990023045163966;1.0345748474499064;3.5969874188785265;HELO_4306;DUF81 family protein;;;;;;;;;HELO_4306;DUF81 family protein;1.446005016382542;-0.14089197356597083;0.03450360407244801;0.7859320038880311;-0.6600730124945109
HELO_4307;79.90091736138648;27.602674333025234;47.092947098478426;62.529483875089774;70.4909958714543;45.172484160851845;6.408954415844349;0.7930691821463733;2.1083863849482705;2.291847998160012;2.2175611317745463;4.626748308715523;HELO_4307;proline racemase family protein;COG3938;Proline racemase/hydroxyproline epimerase;PrdF;HELO_RS18195;E;;;;HELO_4307;proline racemase family protein;1.5000060174908896;0.05879198214920667;0.630728195163341;0.809122707922799;-0.6908833095680906
HELO_4308;71.99672564409539;50.548494867434044;78.34246540649461;70.78237900047391;79.94251029254148;77.46939182744052;3.6697884633563853;4.100974050446971;0.7320485404051977;1.388820094643404;6.461572110823728;4.019643559353792;HELO_4308;DUF1338 family protein;COG5383;Uncharacterized metalloenzyme YdcJ, glyoxalase superfamily;YdcJ;HELO_RS18200;R;;;;HELO_4308;DUF1338 family protein;0.5019014477735313;0.015963208289154984;0.04476757368456408;-0.10429826709521972;-0.606199714868751
HELO_4309;35.69803119833116;15.026957653734291;23.55927224854152;25.78338358632841;24.343202826524415;22.3598928354039;2.2795332075555597;0.406012837548564;3.0527006439628144;1.5812245420846558;2.042739409342136;2.734457224773783;gabT2;4-aminobutyrate aminotransferase;COG0160;Acetylornithine aminotransferase/4-aminobutyrate aminotransferase;ArgD;HELO_RS18205;E;gabT2; 4-aminobutyrate aminotransferase;2.6.1.19,2.6.1.22,2.6.1.48;gabT2;4-aminobutyrate aminotransferase;1.195202077147922;0.07223415494735619;0.11756520529639314;0.6516690106286118;-0.5435330665193101
HELO_4310;21.455715839095387;13.969187415902647;18.752454531214873;18.349714724806635;18.72629561762677;20.05470283271197;0.4344783220574557;0.38460029730698436;1.1259954173741156;1.1092386092684758;2.359828900810046;2.783829874403783;HELO_4310;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS18210;K;;gabT2;;HELO_4310;LysR family transcription regulator;0.5850868042326542;-0.09211057299233882;-0.09402245420891475;0.0929401994424719;-0.49214660479018235
HELO_4311;26.89298827555237;9.017018432408364;26.383021102442928;25.876622974710482;23.112151996641913;26.057324996040208;1.4119605409282496;0.17927096635252662;1.4846174847963551;1.2843397966660632;2.6703787651699535;1.3408428506464136;HELO_4311;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS18215;K;;;;HELO_4311;LysR family transcription regulator;1.4774493497698051;0.017262409124458422;-0.16625879885867967;0.04388328841910738;-1.4335660613506978
HELO_4312;8.935161078849214;3.7184639057030124;5.737546653842876;5.441446244649605;8.256347280987482;6.116326544783425;0.38058160063383323;0.322619172004959;0.9555553744222254;0.41601200429336455;0.2983916131161211;1.0820197866421681;HELO_4312;aldehyde dehydrogenase;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS18220;I;;;1.2.1.3;HELO_4312;aldehyde dehydrogenase;1.0742260909434025;-0.07890935486952921;0.3793102800567292;0.48141064544419887;-0.5928154454992036
HELO_4313;4.923876157584891;1.7653841192113493;2.437046402406874;2.8604794076524525;3.000610906449685;2.659456807547745;0.29115402970674137;0.09227428484247212;0.32385248543273043;0.3017282616256352;0.6313214282960157;0.30435397031292655;HELO_4313;NSS family transport protein;COG0733;Na+-dependent transporter, SNF family;YocR;HELO_RS18225;R;;;;HELO_4313;NSS family transport protein;1.0990615919223041;-0.0904601883941103;0.1285908035262684;0.6949119629045641;-0.40414962901774
HELO_4314;3.8500048258533828;1.9267654145717756;1.2224695249823305;1.8071332668641757;1.6975453412346002;1.384850653261324;0.8537723573438051;0.35814197996649716;0.9066371608240017;0.486940655593332;1.6312570942953097;0.6954438322634975;HELO_4314;uncharacterized protein;;;;;;;;;HELO_4314;uncharacterized protein;0.7286790669918304;-0.10173528640348506;0.1777482861875641;1.0240872597862691;0.29540819279443875
HELO_4315;7.079707121994354;4.996554145324196;5.496520317645735;6.272592028372074;7.120442553369941;5.078799362989758;0.6753662657271198;0.4433562222718633;0.5124348718907535;1.3227869165548494;1.3028430876211097;0.7783126053216252;HELO_4315;FAD-dependent oxidoreductase;COG0665;Glycine/D-amino acid oxidase (deaminating);DadA;HELO_RS18235;E;;;;HELO_4315;FAD-dependent oxidoreductase;0.430169288462638;0.09588078317298931;0.4177719525827652;0.41051659632094095;-0.01965269214169707
HELO_4316;9.637388866957624;14.878837423826438;157.53505995083222;173.41162044237117;109.63869888812548;160.82858858749174;2.0307606904053905;1.8283811738065123;2.701610692654951;16.575678867598505;5.309327323726436;34.19374117452783;aapP;ABC-type transport system ATP-binding protein AapP;COG1126;ABC-type polar amino acid transport system, ATPase component;GlnQ;HELO_RS18240;E;aapP; ABC-type transport system ATP-binding protein AapP;7.4.2.1;aapP;ABC-type transport system ATP-binding protein AapP;-0.5779612292060228;-0.029664569384031836;-0.5486104007373553;-3.9272505316420183;-3.3492893024359955
HELO_4317;6.763540021223047;11.659706251607593;91.31922249547836;98.19528471059944;49.154676768500345;100.79284542421978;0.29589374190596684;1.0223244753557548;0.981417681816095;9.013159580732342;2.0676443503887185;23.26071719644485;aapM;ABC-type transport system permease protein AapM;COG0765;ABC-type amino acid transport system, permease component;HisM;HELO_RS18245;E;aapM; ABC-type transport system permease protein AapM;;aapM;ABC-type transport system permease protein AapM;-0.7054573816522005;-0.14093318533158516;-1.0211800251522254;-3.712777711059486;-3.0073203294072854
HELO_4318;8.583614574049033;15.677962051761654;117.04379028979595;132.8631009415066;52.024296964495306;134.03632234281275;0.8781469231511361;0.6124295206317752;4.423942698558518;11.129993091593082;2.990907398411434;29.659592764645566;aapQ;ABC-type transport system permease protein AapQ;COG4597;ABC-type amino acid transport system, permease component;BatB;HELO_RS18250;E;aapQ; ABC-type transport system permease protein AapQ;;aapQ;ABC-type transport system permease protein AapQ;-0.7993012174782934;-0.19402536811588256;-1.3486220258297674;-3.816633820110121;-3.0173326026318277
HELO_4319;101.74805372462724;58.49962100746768;520.9177494657454;685.9249030715741;317.13026042739824;549.7202957905823;3.0387057850668113;1.4667944739168832;34.45934695098739;64.79763182738601;29.814581776794356;115.70610203821138;aapJ;ABC-type transport system periplasmic substrate-binding protein AapJ;COG0834;ABC-type amino acid transport/signal transduction system, periplasmic component/domain;HisJ;HELO_RS18255;TE;aapJ; ABC-type transport system periplasmic substrate-binding protein AapJ;;aapJ;ABC-type transport system periplasmic substrate-binding protein AapJ;0.7881586822497599;-0.0774973111531434;-0.7917021703600735;-2.422208711028018;-3.210367393277778
HELO_4320;20.8348656135047;7.873740693235796;10.417585807016613;10.417445455794585;9.147136470568178;9.078248021038123;0.7975205647309408;0.6273141088699493;0.9527775417595952;1.5384590683744894;0.5151152224996908;1.2386448597073778;HELO_4320;sensor histidine kinase;COG0642;Signal transduction histidine kinase;BaeS;HELO_RS18260;T;;aapJ;2.7.13.3;HELO_4320;sensor histidine kinase;1.2990193511003914;0.18001276618077844;0.009827789318985314;1.1153887859096923;-0.1836305651906991
HELO_4321;41.10485865610853;21.47564126913262;41.941176987413144;41.15078946926278;41.29736968771186;39.55480816266311;1.3695158682868531;0.36951516318673017;4.201000121574236;3.2706114152550683;3.475700017403063;4.922994136674933;HELO_4321;response regulator/HTH domain transcription regulator;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS18265;KT;;;;HELO_4321;response regulator/HTH domain transcription regulator;0.9056244425996276;0.08248876503409086;0.06069498046667654;0.05411375156572085;-0.8515106910339068
HELO_4322;44.019288901597285;8.625991608446048;19.41679733272113;34.17217435527083;72.60240114622263;13.617416213279578;5.100489267287821;1.559833322208765;5.725426083971783;8.701246603308334;21.802939051662996;2.4146558719097166;HELO_4322;uncharacterized protein;;;;;;;;;HELO_4322;uncharacterized protein;2.225536198271283;0.48206825472629466;2.3320645105429043;1.622854947160286;-0.6026812511109969
HELO_4323;11.27907807749012;3.928889600364433;3.052908133077763;5.14753882980125;10.494781065039044;3.7492048161288754;0.6213456383188294;0.7468367734512543;0.6116019574588097;0.16718140375746413;1.0267774541088748;0.5905762844572532;HELO_4323;cytochrome domain protein;COG4117;Thiosulfate reductase cytochrome b subunit;YdhU;HELO_RS18275;P;;;;HELO_4323;cytochrome domain protein;1.3168676738270717;-0.2287285014779088;1.275221107174462;1.3704443652338614;0.05357669140678967
HELO_4324;5.267556420026756;1.7893290815610439;3.073448161760712;3.849074482464463;7.2196012970004295;2.6269843261956796;0.3300734875161496;0.3908204117242201;1.1159818208228505;0.8264992889713407;1.1428763205171883;0.32060567159225045;HELO_4324;molybdopterin-binding domain protein;COG2041;Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases;MsrP;HELO_RS18280;C;;;;HELO_4324;molybdopterin-binding domain protein;1.1679849263732476;0.16748003793595734;1.1802979049106268;0.7891325673416634;-0.3788523590315842
HELO_4325;36.034851355348685;18.291849429571887;45.496441541222225;41.53432128705134;33.78467593295772;35.794242629944925;2.4233749871507313;2.218542817503264;2.251832768978201;4.347224458444356;4.542081524848675;0.03875135466795141;trpI;LysR family transcription regulator TrpI;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS18285;K;trpI; LysR family transcription regulator TrpI;;trpI;LysR family transcription regulator TrpI;0.940892091546111;0.3376402697313683;-0.08102815850945344;0.00940350816051616;-0.9314885833855948
HELO_4326;6.417706468648787;69.77641513826188;67.47258609779753;1.6562525745346628;1.2620219220201208;72.69991407529703;0.4753179002094378;1.1808189783286174;15.736720965212402;0.35998306873909447;0.3440146238007611;10.954385770165839;trpB1;tryptophan synthase beta subunit;COG0133;Tryptophan synthase beta chain;TrpB;HELO_RS18290;E;trpB1; tryptophan synthase beta subunit;4.2.1.20;trpB1;tryptophan synthase beta subunit;-3.25422360620064;-0.10613643562727404;-5.025978121168751;-3.3126178531538;-0.05839424695315998
HELO_4327;8.644081989374056;75.78933371364484;63.016906680617886;2.25509655691033;1.5754807523822498;78.30329238766478;0.6972146255816364;1.3293798729619402;11.963618032675116;0.7132042139777878;0.7561051761149061;4.606824367029751;trpA1;tryptophan synthase alpha subunit;COG0159;Tryptophan synthase alpha chain;TrpA;HELO_RS18295;E;trpA1; tryptophan synthase alpha subunit;4.2.1.20;trpA1;tryptophan synthase alpha subunit;-2.9931901086555333;-0.3089277956479739;-4.944467099319449;-3.039664941476644;-0.046474832821110645
HELO_4328;34.13627920055251;52.7031941363119;57.25232779021129;38.5153738896606;33.01485157821238;62.577212473935134;1.7409410247332595;5.29287003574148;5.620564280827634;1.5431527170522805;6.060795672017744;11.958543742174378;HELO_4328;uncharacterized protein;;;;;;;;;HELO_4328;uncharacterized protein;-0.612046475308671;-0.12619406159393787;-0.9023449692707324;-0.8555483398087116;-0.24350186450004063
HELO_4329;195.70502603904762;277.44488324168583;134.38444932024325;111.13571791624315;163.6636007733077;147.47185181852856;13.83160492447413;21.0316719905671;8.388900302766638;9.27000305849944;14.991402709596317;17.491632235342287;ahpF;alkyl hydroperoxide reductase subunit AhpF;COG3634;Alkyl hydroperoxide reductase subunit AhpF;AhpF;HELO_RS18305;V;ahpF; alkyl hydroperoxide reductase subunit AhpF;1.8.1.-;ahpF;alkyl hydroperoxide reductase subunit AhpF;-0.5013579610282033;-0.1331274062165022;0.14933223741166657;0.40584437840310095;0.9072023394313042
HELO_4330;1610.5266422502334;2111.2238704536126;2070.0371115951475;1571.9512912826722;2342.743438878122;2031.839853573533;49.48792795532264;46.98271152301953;75.35885093443748;99.23652565274185;133.5270117405011;136.46858899204656;ahpC;alkyl hydroperoxide reductase subunit AhpC;COG0450;Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin);AhpC;HELO_RS18310;V;ahpC; alkyl hydroperoxide reductase subunit AhpC;1.11.1.26;ahpC;alkyl hydroperoxide reductase subunit AhpC;-0.3903347115407012;0.026856841278243948;0.20531808715367994;-0.33506852496944184;0.05526618657125937
HELO_4331;50.531400197905874;183.59498583129144;12.912106050118952;3.076786903037321;73.37208176762431;56.45544132938028;4.795498985844973;12.650726133036294;6.346383460528123;0.5082251113295861;58.53043196225186;72.62481344298061;fliA;RNA polymerase sigma factor FliA;COG1191;DNA-directed RNA polymerase specialized sigma subunit;FliA;HELO_RS18315;K;fliA; RNA polymerase sigma factor FliA;;fliA;RNA polymerase sigma factor FliA;-1.840839666798984;-2.0461026948020904;0.3723176254783134;-0.15699173651117615;1.6838479302878078
HELO_4332;59.10142092539271;170.61451149958944;16.368014600486898;2.8446293270967047;81.80594601400306;71.9611789701709;6.0983294900036285;7.7764003085937246;6.865686140526905;0.8796015407385759;62.41862281921278;93.27182965868948;flhE;flagellar protein FlhE;;;;;;;;;flhE;flagellar protein FlhE;-1.513700545578394;-2.0706961981387026;0.18260532446773503;-0.2797299422936934;1.2339706032847007
HELO_4333;40.80337146941197;194.8222076177129;14.169499293638085;3.1707199310075787;79.03040957117763;59.21194145229348;2.5659178485146232;7.852417624177284;6.28769298869022;0.20153280757888586;62.61589357446536;78.10952532069443;flhA;flagellar biosynthetic protein FlhA;COG1298;Flagellar biosynthesis protein FlhA;FlhA;HELO_RS18325;N;flhA; flagellar biosynthetic protein FlhA;;flhA;flagellar biosynthetic protein FlhA;-2.227853179584347;-1.9888761692157528;0.4104986566031066;-0.5264303346116357;1.7014228449727113
HELO_4334;100.84161796688367;429.42062664233595;36.11579567045816;2.394593057354841;233.54239888052936;160.16105109412598;6.462071139317571;16.21735796458006;17.04902106175016;0.4903120367967389;175.43002484426296;217.80017007353234;flhB;flagellar biosynthetic protein FlhB;COG1377;Flagellar biosynthesis protein FlhB;FlhB;HELO_RS18330;N;flhB; flagellar biosynthetic protein FlhB;;flhB;flagellar biosynthetic protein FlhB;-2.0794199717079564;-2.1183979178187506;0.5413456264011263;-0.6621758751435713;1.417244096564385
HELO_4335;18.146520860863063;603.4499845851809;101.1126316933411;6.292013324546029;408.1998212474034;286.3388305293692;1.3252986289479696;41.81397096297401;47.92292651424618;0.3188078478930621;194.6069582472758;327.0934850894892;cheZ;protein phosphatase CheZ;COG3143;Phosphoaspartate phosphatase CheZ, dephosphorylates CheY~P;CheZ;HELO_RS18335;TN;cheZ; protein phosphatase CheZ;;cheZ;protein phosphatase CheZ;-4.980468801041278;-1.4925916259136445;0.5100525452215674;-3.9075988025516235;1.0728699984896544
HELO_4336;23.57035519753693;847.0667981927799;252.68698825187008;13.684232683341904;953.8833867737495;762.1875705292408;0.583538554094572;13.233042948713885;132.6605925557338;1.111182338315699;494.26761563881155;878.5451622765619;cheB;chemotaxis-specific methylesterase CheB;COG2201;Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains;CheB;HELO_RS18345;T;cheB; chemotaxis-specific methylesterase CheB;3.1.1.61,3.5.1.44;cheB;chemotaxis-specific methylesterase CheB;-5.109187284437451;-1.5889881507686487;0.3232868822265367;-4.957047056368027;0.15214022806942396
HELO_4337;6.985680811072612;401.3854748500327;75.30898863707932;3.9176799572437013;283.0498803800983;264.2873769379385;0.23644596755900832;24.23530696970883;36.39589838328319;0.2558329069829528;187.94105832794153;320.281689375932;cheR;protein-glutamate O-methyltransferase CheR;COG1352;Methylase of chemotaxis methyl-accepting proteins;CheR;HELO_RS18350;T;cheR; protein-glutamate O-methyltransferase CheR;2.1.1.80;cheR;protein-glutamate O-methyltransferase CheR;-5.655019009655417;-1.7976311189877991;0.09858826540326504;-5.053996811425332;0.6010221982300852
HELO_4338;13.878361717125777;737.7657084017756;189.4086951317012;7.704465606096396;735.7276128170166;593.6487087324142;0.49854176619207335;38.38889969695784;102.67648745493233;0.5131071415142823;416.1392813410112;710.400573033465;HELO_4338;methyl-accepting chemotaxis sensory transducer;COG2202;PAS domain;PAS;HELO_RS18355;T;;cheR;;HELO_4338;methyl-accepting chemotaxis sensory transducer;-5.633829319105965;-1.6429382800820713;0.3090936745689987;-5.320750059213395;0.3130792598925698
HELO_4339;11.617726212054357;479.72759338102713;133.1937389459964;5.776920239123785;561.6523049396036;447.50679343097573;1.1974938766250212;10.197695970506649;67.59436799568309;0.2921229162672375;307.47096951553715;532.7770531571156;HELO_4339;methyl-accepting chemotaxis sensory transducer;COG0840;Methyl-accepting chemotaxis protein (MCP);Tar;HELO_RS18360;T;;;;HELO_4339;methyl-accepting chemotaxis sensory transducer;-5.2516957586146145;-1.7408124759495536;0.32711383633560764;-5.151605980701243;0.10008977791337159
HELO_4340;12.221299666439535;559.5125285475834;101.8135016228078;2.856179387548592;461.63675777409884;331.5099027119774;1.0046426401256112;7.615310993382963;51.88316553208343;0.5742587808267139;260.4562019845601;401.2418041114537;HELO_4340;methyl-accepting chemotaxis sensory transducer;COG4564;Signal transduction histidine kinase;;HELO_RS18365;T;;;;HELO_4340;methyl-accepting chemotaxis sensory transducer;-5.405810713201875;-1.6933675733290627;0.4764825894797369;-4.652461399936843;0.7533493132650317
HELO_4341;7.159982632952208;375.3705683176109;59.67546926845008;1.2533312279805995;309.82768462771196;193.42923088228235;0.0924434857545258;18.410140337766666;35.17192117994547;0.29495619980441157;174.85077660853153;223.77097615586118;cheW;purine-binding taxis protein CheW;COG0835;Chemotaxis signal transduction protein CheW;CheW;HELO_RS18370;T;cheW; purine-binding taxis protein CheW;;cheW;purine-binding taxis protein CheW;-5.5274439237168025;-1.6800598664891861;0.6768698737009053;-4.574535241019008;0.9529086826977942
HELO_4342;10.365073476392444;436.06140702415945;90.41175945092141;2.2172345775632603;407.022185328651;280.0743865444204;0.6135412667475542;4.728812225405067;43.830029384859564;0.36870399041500335;206.1300744764495;328.7961376122522;cheA;taxis sensor histidine kinase CheA;COG0643;Chemotaxis protein histidine kinase CheA;CheA;HELO_RS18375;T;cheA; taxis sensor histidine kinase CheA;2.7.13.3;cheA;taxis sensor histidine kinase CheA;-5.265157075804895;-1.6205003168417456;0.5376956064803746;-4.628273074815253;0.6368840009896424
HELO_4343;9.01573882468992;336.7846848021863;56.42918854999822;1.9743956344887896;269.2050919625546;162.71121135208105;0.8264799645014151;14.578751074939694;26.492841992859876;0.49063126970178356;166.38142311797424;178.21540957654747;motB;flagellar motor protein MotB;COG1360;Flagellar motor protein MotB;MotB;HELO_RS18380;N;motB; flagellar motor protein MotB;;motB;flagellar motor protein MotB;-5.075763165093316;-1.5112970422365581;0.7229017376780238;-4.030812371986037;1.0449507931072795
HELO_4344;16.970535612427625;374.35184977895165;71.33124385379791;1.0462417445439285;323.70434865117386;192.54608227812216;0.7407697372737091;3.5176325655426597;34.39580970023166;0.13260462999490455;197.26345249019687;209.14090041540544;motA;flagellar motor protein MotA;COG1291;Flagellar motor component MotA;MotA;HELO_RS18385;N;motA; flagellar motor protein MotA;;motA;flagellar motor protein MotA;-4.3845382786124;-1.4199862386918483;0.7464496010853958;-3.428971790999145;0.9555664876132548
HELO_4345;210.42467630749957;608.0538353804455;64.94314743932554;17.17275991561844;481.5349911968533;360.6794951798359;22.00423823610881;59.02315292097715;21.507069080459374;0.43691240749401683;411.0272238252722;512.765890764638;flhC;flagellar transcription regulator FlhC;;;;;;;;;flhC;flagellar transcription regulator FlhC;-1.5264259863604117;-2.4554171560996894;0.4159217546137661;-0.7745680392493046;0.7518579471111071
HELO_4346;9.873150787180615;133.4963400802808;16.723757555365292;1.7146841888471673;82.52557694390873;51.787723284504516;0.24427755177241817;9.685135826981726;7.394403584606107;0.2767778075858104;58.342061330270994;65.0090277727202;HELO_4346;FlhB_Cterm domain protein;COG2257;Type III secretion system substrate exporter, FlhB-like;YlqH;HELO_RS18400;U;;flhD;;HELO_4346;FlhB_Cterm domain protein;-3.628724948982662;-1.5745179470970525;0.662015598422208;-2.2794323838864536;1.3492925650962082
HELO_4347;19.790702911182375;230.885040815633;31.42114733839709;2.131309326947068;150.14314019931868;104.45594175018708;0.6007016859676613;5.852799199113788;11.511999932939846;0.21961591618658657;92.38308096836343;126.70794731573015;HELO_4347;uncharacterized protein;;;;;;;;;HELO_4347;uncharacterized protein;-3.479399312891619;-1.7016333320167618;0.5192751183028941;-2.3426299437258233;1.1367693691657959
HELO_4348;28.768677683839844;356.0764789563278;26.830622691351135;2.783228566569043;109.5591693414661;79.46762588041439;1.7609072729720388;27.084399047835227;13.622393666119306;0.42946851528371527;75.51276597009668;88.67945912413445;fliT;flagellar protein FliT;;;;;;;;;fliT;flagellar protein FliT;-3.5843660610404635;-1.5317352796413806;0.4583383084429071;-1.4346133290998075;2.149752731940656
HELO_4349;24.336916939935524;313.10578589089505;69.24058760324662;6.512614246144811;268.0254895330087;191.56723100679858;2.8197444068859543;40.46035969379252;32.495425642655974;1.7705915764275395;147.46545832280526;217.28336022964194;fliS;flagellar protein FliS;COG1516;Flagellin-specific chaperone FliS;FliS;HELO_RS18415;NU;fliS; flagellar protein FliS;;fliS;flagellar protein FliS;-3.6319376284697;-1.4549854029276759;0.48238064927849944;-2.926049332450856;0.705888296018844
HELO_4350;22.864798529073607;167.97990789316233;10.736476357546524;4.400926607160717;29.15885385677503;32.46787617465572;2.6733262555807973;16.635391845797038;4.332760311426709;0.7603555849252907;22.422514330085683;41.76835208224412;HELO_4350;DUF2835 family protein;;;;;;;;;HELO_4350;DUF2835 family protein;-2.8238956548225636;-1.5117776693837182;-0.15019540035924894;-0.4878928455379432;2.3360028092846203
HELO_4351;35.44555666753902;550.9471103297805;40.26560875912664;6.436675994393478;194.00979580824114;209.88625723582297;2.865573416168378;16.975538583284948;20.242757117787328;0.6178717109950959;155.28787731652335;292.0734718903825;HELO_4351;uncharacterized protein;COG3914;Predicted O-linked N-acetylglucosamine transferase, SPINDLY family;Spy;HELO_RS18425;O;;;;HELO_4351;uncharacterized protein;-3.920715187750404;-2.3534532539091844;-0.11291848668532278;-2.5326502411480423;1.3880649466023618
HELO_4352;85.53728860651375;5724.532487428813;1177.7196295777903;13.93889617418425;5891.440005740443;4246.347666477906;4.352592125314579;423.70282499800146;660.8682354675914;0.27394227752860356;3567.7053376508616;5237.160406704023;fliC1;flagellin;COG1344;Flagellin and related hook-associated protein FlgL;FlgL;HELO_RS18430;N;fliC1; flagellin;;fliC1;flagellin;-6.047944144287551;-1.8493416057938497;0.4723029593920316;-5.617096476212361;0.4308476680751898
HELO_4353;53.32661611294552;3541.3591676026967;1226.4289198681936;11.432001882365626;6452.480641571412;4627.166688122804;1.6743082693877698;54.69214008389945;689.1650261622045;0.9376759802326226;3991.426228292432;5722.4229605246865;fliC2;flagellin;COG1344;Flagellin and related hook-associated protein FlgL;FlgL;HELO_RS18435;N;fliC2; flagellin;;fliC2;flagellin;-6.026907499846744;-1.9148013446933234;0.47963665284704504;-6.412637827819029;-0.38573032797228457
HELO_4354;10.438701625077938;216.29727934359576;79.13787776083328;2.634700073419285;344.5910550971805;237.2586695243068;0.5216945746872792;4.9377095504269946;42.99802677578559;0.3691499234339268;202.36509568344238;272.15590426458675;fliD2;flagellar capping protein FliD;COG1345;Flagellar capping protein FliD;FliD;HELO_RS18440;N;fliD2; flagellar capping protein FliD;;fliD2;flagellar capping protein FliD;-4.247674901206764;-1.571972501036595;0.5365371663643366;-4.380533500215289;-0.13285859900852603
HELO_4355;25.16084821353537;746.1850583708423;163.5326318335033;12.84642274408254;655.7670570196964;466.64105843817475;1.7340761379237293;31.28799211113531;78.88378357912453;1.6387372804954385;361.22761321364726;527.1921056999904;fliD1;flagellar capping protein FliD;COG1345;Flagellar capping protein FliD;FliD;HELO_RS18445;N;fliD1; flagellar capping protein FliD;;fliD1;flagellar capping protein FliD;-4.835984382208147;-1.5070278599589972;0.4899801616705197;-4.1599203794490665;0.6760640027590803
HELO_4356;11.6199472568668;576.9025868566798;158.80022744121075;3.662554936176385;682.1134123827487;521.6572072424258;0.38860869275397125;23.20673446463528;84.56682852111238;0.5555282148821801;370.8599949022474;629.5227118861995;tar1;methyl-accepting chemotaxis sensory transducer;COG0840;Methyl-accepting chemotaxis protein (MCP);Tar;HELO_RS18450;T;tar1; methyl-accepting chemotaxis sensory transducer;;tar1;methyl-accepting chemotaxis sensory transducer;-5.517048541918999;-1.709595581295062;0.3862600757031114;-5.372087257004981;0.14496128491401805
HELO_4357;6.6944055493574615;197.09725264189055;73.14404446503892;3.264595226905841;314.7768234843966;191.81785842637683;0.8707656492916237;14.422377179496902;30.301475408469976;1.2387476691683774;143.58301079907002;207.56741227679683;flaG;FlaG family protein;;;;;;;;;flaG;FlaG family protein;-4.68625518996023;-1.378835957820571;0.7116666106859357;-4.6472849953976;0.038970194562629956
HELO_4358;71.38833027079512;246.51555364462104;43.498501990684254;15.225027379612918;202.10923494844852;194.37683260687268;6.970637798461586;40.11936431864731;12.504663238286978;0.7624733134218898;143.74055730590882;261.30050445115495;fliE;flagellar hook-basal body complex protein FliE;COG1677;Flagellar hook-basal body complex protein FliE;FliE;HELO_RS18460;N;fliE; flagellar hook-basal body complex protein FliE;;fliE;flagellar hook-basal body complex protein FliE;-1.7736901414711506;-2.1344307308199726;0.05599643186299463;-1.4324303613932257;0.3412597800779249
HELO_4359;67.42181301271215;219.56888262213454;21.74588527910953;0.9676023381646351;101.60895537877992;94.6559279570587;3.224893518440056;5.446487633941487;11.298128874584233;0.397216360988521;86.27720053390675;126.1349750572671;fliF;flagellar M-ring protein FliF;COG1766;Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ;FliF;HELO_RS18465;NU;fliF; flagellar M-ring protein FliF;;fliF;flagellar M-ring protein FliF;-1.6887010353512961;-2.0722487915543724;0.10123036754412595;-0.48339804500984673;1.2053029903414494
HELO_4360;59.12059534418652;170.7552763254702;12.956183371629587;0.907215817295819;71.20072729938504;61.09823445774108;3.9151141901369377;5.008143042395412;6.392871194064437;0.3817885599661907;51.21168233131851;82.94546902755485;fliG;flagellar motor switch protein FliG;COG1536;Flagellar motor switch protein FliG;FliG;HELO_RS18470;N;fliG; flagellar motor switch protein FliG;;fliG;flagellar motor switch protein FliG;-1.514423218619119;-2.1536477926528788;0.21746111875096474;-0.046692955518169654;1.4677302631009495
HELO_4361;109.91612636458665;357.98621390713976;30.438048990381716;1.2683839967909354;138.75641968148906;124.7856339246128;1.920153938373375;8.251818264463845;13.982411308713367;0.3579978666416394;111.31815108028408;174.5835640849223;fliH;flagellar assembly protein FliH;COG1317;Flagellar biosynthesis/type III secretory pathway protein FliH;FliH;HELO_RS18475;NU;fliH; flagellar assembly protein FliH;;fliH;flagellar assembly protein FliH;-1.6944593038341473;-2.000383566828318;0.151947394181577;-0.18149802261941694;1.5129612812147304
HELO_4362;73.02699552612107;230.1186370612975;27.99932630220199;2.526174887256748;156.01806178699056;137.15441899333732;4.060668271905026;6.933206440079993;15.625182501865226;0.6117735326419149;122.41813102425162;188.13510448200117;fliI;flagellar protein export ATPase FliI;COG1157;Flagellar biosynthesis/type III secretory pathway ATPase FliI;FliI;HELO_RS18480;NU;fliI; flagellar protein export ATPase FliI;7.4.2.8;fliI;flagellar protein export ATPase FliI;-1.6425102198792771;-2.2521904190119173;0.18464881308018555;-0.9001583273988212;0.742351892480456
HELO_4363;60.037736599433856;151.7666403265241;11.529105823036176;0.2936548081071207;78.3942428736771;63.466894350686324;5.202779491571281;7.4670420100170665;7.459475332412979;0.24895314857633571;72.33590105902954;83.01015800355569;fliJ;flagellar protein FliJ;COG2882;Flagellar biosynthesis chaperone FliJ;FliJ;HELO_RS18485;N;fliJ; flagellar protein FliJ;;fliJ;flagellar protein FliJ;-1.3235561659625432;-2.3632750281927457;0.30047591250814243;-0.07885701913145926;1.244699146831084
HELO_4364;60.50385071298992;172.7400070883109;31.654292032578585;1.8721255104096315;202.7989812353129;171.7065836751036;0.37012952728681087;23.898752780170156;16.46074884145251;0.18315381699438815;153.51425254271896;233.31114311292288;fliK;flagellar hook-length control protein FliK;COG3144;Flagellar hook-length control protein FliK;FliK;HELO_RS18490;N;fliK; flagellar hook-length control protein FliK;;fliK;flagellar hook-length control protein FliK;-1.4981813569804343;-2.4029785452043724;0.23882375938973865;-1.4895744357688336;0.008606921211600671
HELO_4365;104.51143513675545;510.4848792524854;39.81940934133259;2.422591306481702;231.73235408355004;241.13936572693623;2.6289436724967;27.81829721502024;21.31283799198621;0.8407733627961015;205.80323808358298;342.5494804560109;fliL;flagellar basal body-associated protein FliL;COG1580;Flagellar basal body-associated protein FliL;FliL;HELO_RS18495;N;fliL; flagellar basal body-associated protein FliL;;fliL;flagellar basal body-associated protein FliL;-2.277292226936047;-2.5685104322985266;-0.057165858204643705;-1.1984382800103184;1.0788539469257286
HELO_4366;63.4544206735869;308.24630385179154;21.52563394534286;1.7254346175575888;135.93186398968706;117.75168940043869;1.753061924099191;8.305360476246113;11.389558916357302;0.10573653738544522;106.2142920326275;161.7748590123865;fliM;flagellar motor switch protein FliM;COG1868;Flagellar motor switch protein FliM;FliM;HELO_RS18500;N;fliM; flagellar motor switch protein FliM;;fliM;flagellar motor switch protein FliM;-2.2624051362085513;-2.398308423940936;0.2055101623761848;-0.8815968220066166;1.3808083142019347
HELO_4367;67.11350599710714;332.6386210885099;12.679652706541523;1.2296064723076547;77.67127843718343;69.68932758782823;3.868964726294175;10.38770095928082;4.846746525613373;0.17651280039105074;69.9367021811579;95.17596018808887;fliO;flagellar protein FliO;COG3190;Flagellar biogenesis protein FliO;FliO;HELO_RS18510;N;fliO; flagellar protein FliO;;fliO;flagellar protein FliO;-2.2922735020128986;-2.3694608146016503;0.1543446093835259;-0.053551525004639444;2.238721977008259
HELO_4368;29.734718664953096;155.846999758956;6.562357009443919;0.6220844908109845;38.61601719815016;33.80771817742612;1.637918355579716;9.056382978384011;4.495894883646043;0.1995863331185925;32.81992348822364;47.752293291952654;fliP;flagellar biosynthetic protein FliP;COG1338;Flagellar biosynthesis protein FliP;FliP;HELO_RS18515;N;fliP; flagellar biosynthetic protein FliP;;fliP;flagellar biosynthetic protein FliP;-2.3514167486067823;-2.2024993773006227;0.1866766047894579;-0.17953796198349004;2.1718787866232923
HELO_4369;20.31478765371732;84.41800205302981;1.7668410764990459;0.2446350801227698;20.621701185423913;13.54879982386594;0.3454390625850309;8.346961710054105;1.2092446110576698;0.24589807092074353;16.953534964922955;17.561710974619523;fliQ;flagellar biosynthetic protein FliQ;COG1987;Flagellar biosynthesis protein FliQ;FliQ;HELO_RS18520;N;fliQ; flagellar biosynthetic protein FliQ;;fliQ;flagellar biosynthetic protein FliQ;-2.0026854707224997;-2.3945884605579235;0.5715798925123745;0.5509545370762665;2.553640007798766
HELO_4370;11.89770415665633;43.92974908584508;2.385930272519356;0.5295200441929077;11.128967080058985;8.056944919770759;0.9442824082878455;2.6231634552913703;1.1388476546657729;0.1787426457187309;9.109063489429005;10.46599767191403;fliR;flagellar biosynthetic protein FliR;COG1684;Flagellar biosynthesis protein FliR;FliR;HELO_RS18525;N;fliR; flagellar biosynthetic protein FliR;;fliR;flagellar biosynthetic protein FliR;-1.800556722058103;-1.4194722200962853;0.42136030485005627;0.5100178940723534;2.3105746161304563
HELO_4371;64.81319899473232;500.4332917464226;90.43176179774848;4.777530686097088;494.67947574747785;309.97275696476095;2.0868519161313683;9.534689085058952;45.99510780520575;0.5920267373466599;303.65117070505676;375.4168253146431;flgL;flagellar hook-associated protein FlgL;COG1344;Flagellin and related hook-associated protein FlgL;FlgL;HELO_RS18530;N;flgL; flagellar hook-associated protein FlgL;;flgL;flagellar hook-associated protein FlgL;-2.9296089304133073;-1.7660208728208238;0.6726193260282649;-2.240339343317247;0.6892695870960601
HELO_4372;62.7253972078016;790.1350522521025;124.11467217012178;6.071291897315209;636.4917374965789;405.7714118750096;2.7320939593019435;19.09912206133905;60.12029530473705;0.15388674671815222;370.8436385106225;487.73024423061247;flgK;flagellar hook-associated protein FlgK;COG1256;Flagellar hook-associated protein FlgK;FlgK;HELO_RS18535;N;flgK; flagellar hook-associated protein FlgK;;flgK;flagellar hook-associated protein FlgK;-3.6339836279180178;-1.7009673053792875;0.6481883540488784;-2.674277923460566;0.959705704457452
HELO_4373;97.17429230585829;350.1825121463664;41.79738760094117;5.319553750155895;259.7474781837272;194.80257559256333;3.5087662902515544;11.857149439844086;18.61180770460544;0.6750275049132338;199.85425571634738;268.17752920297295;flgJ;peptidoglycan hydrolase FlgJ;COG3951;Rod binding protein domain;FlgJ1;HELO_RS18540;N;flgJ; peptidoglycan hydrolase FlgJ;;flgJ;peptidoglycan hydrolase FlgJ;-1.8388038063980545;-2.1938051015641644;0.4132535574864198;-0.9959825440126915;0.842821262385363
HELO_4374;74.0669204301961;301.06243205742015;29.34407959870582;4.897494328554689;191.76353396179618;153.26853428145637;4.512028416066577;7.348199444471559;13.575269613151532;0.8654296885688479;151.47905054532683;210.3934707038648;flgI;flagellar basal body P-ring protein FlgI;COG1706;Flagellar basal body P-ring protein FlgI;FlgI;HELO_RS18545;N;flgI; flagellar basal body P-ring protein FlgI;;flgI;flagellar basal body P-ring protein FlgI;-2.008597561417118;-2.345956863123855;0.32138832610079593;-1.039194625737335;0.9694029356797831
HELO_4375;87.27589009143924;325.49796355032254;38.95337344575793;2.3716823769861253;301.4545228263442;204.46953184179907;5.808796031968705;14.91847678332963;22.532563630339347;1.2179922718971492;225.53031121875085;280.22452693574655;flgH;flagellar L-ring protein FlgH;COG2063;Flagellar basal body L-ring protein FlgH;FlgH;HELO_RS18550;N;flgH; flagellar L-ring protein FlgH;;flgH;flagellar L-ring protein FlgH;-1.8869826253918864;-2.3625352522307947;0.5577937555656636;-1.2188331110125246;0.6681495143793619
HELO_4376;117.19298808330986;467.308394310212;62.432406025617674;4.879739692748111;449.90023855704266;356.29534340802775;11.27286387016236;21.20637998167942;29.390176482697793;0.8321753610119114;360.9769980268594;497.05805582648594;flgG;flagellar basal-body rod protein FlgG;COG4786;Flagellar basal body rod protein FlgG;FlgG;HELO_RS18555;N;flgG; flagellar basal-body rod protein FlgG;;flgG;flagellar basal-body rod protein FlgG;-1.986314449480047;-2.4938251410277834;0.3356911617042737;-1.5959726628210964;0.3903417866589507
HELO_4377;201.68257697510367;744.7769269950526;74.81204200695743;4.5939592448685;620.3468217326982;440.03253958409965;18.67903106312846;23.83011757698845;36.791962729406244;0.7024863178258478;483.16799331077914;616.842785485494;flgF;flagellar basal-body rod protein FlgF;COG4787;Flagellar basal body rod protein FlgF;FlgF;HELO_RS18560;N;flgF; flagellar basal-body rod protein FlgF;;flgF;flagellar basal-body rod protein FlgF;-1.8795220863921216;-2.5403861726013712;0.49451367057767825;-1.121663025410614;0.7578590609815077
HELO_4378;139.74733209715365;486.43545408831295;81.79559749690185;4.206235658784382;617.7955282426242;408.694104362861;6.811881809202516;20.59415316970218;47.13388846370908;0.08958651128747773;451.74322738108253;562.8976323622977;flgE;flagellar hook protein FlgE;COG1749;Flagellar hook protein FlgE;FlgE;HELO_RS18565;N;flgE; flagellar hook protein FlgE;;flgE;flagellar hook protein FlgE;-1.7921036147950717;-2.3069211698661807;0.5949156390189287;-1.5414395561973402;0.25066405859773155
HELO_4379;111.78512406925798;346.942935216907;31.225703749304717;1.7885139981325882;227.6450779640527;166.70538380416647;4.415064447709476;8.401308503495779;17.912336387323204;0.5863709259678845;173.5494104560637;227.76499317174944;flgD;basal-body rod modification protein FlgD;COG1843;Flagellar hook-capping protein FlgD;FlgD;HELO_RS18570;N;flgD; basal-body rod modification protein FlgD;;flgD;basal-body rod modification protein FlgD;-1.625273920335407;-2.379645234311006;0.44718085849968503;-0.5723522098529887;1.0529217104824182
HELO_4380;119.04604452389272;349.5405010396236;15.424369929993395;0.7648495479809191;122.12329917081779;100.60495992198906;4.28237257533515;8.822883314943462;8.1512011181469;0.10812922769397769;116.18896282885673;143.57656965410317;flgC;flagellar basal-body rod protein FlgC;COG1558;Flagellar basal body rod protein FlgC;FlgC;HELO_RS18575;N;flgC; flagellar basal-body rod protein FlgC;;flgC;flagellar basal-body rod protein FlgC;-1.5459932731209163;-2.6290608978632592;0.27713296520655106;0.2406170379785184;1.7866103110994347
HELO_4381;113.6076753101339;308.4811235528774;33.623699671359525;2.631284477406004;197.63998023413683;183.07974820252915;2.3102209788178856;34.374156138825995;15.230442707685754;0.49943635133991326;161.40705862098446;258.074713590863;flgB;flagellar basal body rod protein FlgB;COG1815;Flagellar basal body rod protein FlgB;FlgB;HELO_RS18580;N;flgB; flagellar basal body rod protein FlgB;;flgB;flagellar basal body rod protein FlgB;-1.433147751542677;-2.41049911985807;0.10982510781630594;-0.6836272502077332;0.7495205013349437
HELO_4382;107.7929897102934;311.9696061646725;35.063658226214145;9.268715552091702;194.12812267436996;183.67168285759678;5.153498713186577;20.847723397636678;11.005190646928947;1.0815878310828384;158.35523521986428;251.025102580745;flgA;flagella basal body P-ring formation protein FlgA;COG1261;Flagellar basal body P-ring formation protein FlgA;FlgA;HELO_RS18585;N;flgA; flagella basal body P-ring formation protein FlgA;;flgA;flagella basal body P-ring formation protein FlgA;-1.5244369608922153;-2.356345010212215;0.07945905647354223;-0.763377066953427;0.7610598939387883
HELO_4383;93.34489020195015;510.9523373848904;125.48185934355513;63.11673388329299;441.1439883039986;271.31593216983134;2.7365180408821743;11.119358011355983;26.204874839805182;7.316508921654024;216.90279465464096;250.0048025796812;flgN;flagella synthesis protein FlgN;COG3418;Flagellar biosynthesis/type III secretory pathway chaperone FlgN;FlgN;HELO_RS18595;NU;flgN; flagella synthesis protein FlgN;;flgN;flagella synthesis protein FlgN;-2.4399932144986316;-1.1063509101837665;0.6992348817470297;-1.529265103966667;0.9107281105319647
HELO_4384;79.45142287218862;21.197730481848126;114.2197764253112;136.78916006029382;79.72855788446024;93.66212424211268;5.376202034748836;1.6355403356232314;14.395079339393197;4.962933641735667;21.78538897285043;25.491277620303716;HELO_4384;diguanylate cyclase / EAL-type diguanylate phosphodiesterase;COG5001;Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain;;HELO_RS18600;T;;flgN;2.7.7.65;HELO_4384;diguanylate cyclase / EAL-type diguanylate phosphodiesterase;1.85770575529585;0.28352916150372387;-0.22970817691020873;-0.23466936005457928;-2.0923751153504293
HELO_4385;156.93584429816897;198.91090846803698;171.13112172552619;320.9386031401794;113.3437055974308;165.7436719919638;11.463833925196536;10.14340478541177;32.71908927286532;9.98581279798236;25.116244891007685;8.039755931498718;HELO_4385;uncharacterized protein;;;;;;;;;HELO_4385;uncharacterized protein;-0.34001856233622174;0.04587595230369512;-0.5442550611013015;-0.07829337650488988;0.26172518583133186
HELO_4386;90.75456332620251;97.080021431428;106.13859596961565;225.87936546154728;77.91935020958299;96.01880779426267;14.65232418411651;8.580053039751203;9.22347995076614;26.18023600914051;11.09756530258462;12.84256061055618;HELO_4386;glutamine amidotransferase domain protein;COG0693;Protein/nucleotide deglycase, PfpI/YajL/DJ-1 family (repair of methylglyoxal-glycated proteins and nucleic acids);YajL;HELO_RS18605;V;;;;HELO_4386;glutamine amidotransferase domain protein;-0.09617938346147437;0.14314193871396963;-0.297885373695121;-0.08048454042060182;0.01569484304087254
HELO_4387;394.3370168811388;279.33711226746476;601.7022341941803;348.26420934403205;347.43402166321835;562.0022776075181;40.97855570101125;1.4226913935706065;55.98917952340364;24.652055057802023;60.49366003180354;84.26030531283524;yxjH;probable methionine synthase YxjH%2C cobalamin-independent;COG0620;Methionine synthase II (cobalamin-independent);MetE;HELO_RS18610;E;yxjH; probable methionine synthase YxjH, cobalamin-independent;2.1.1.14;yxjH;probable methionine synthase YxjH%2C cobalamin-independent;0.4959202990387954;0.09830465412425937;-0.6922552607943988;-0.5100577122873773;-1.0059780113261727
HELO_4388;443.04565186665513;927.1642278524747;1154.3560204103221;948.6436797703254;1657.3880677442323;1112.3655929718918;35.796016122635095;82.36026851395717;102.90935638746681;39.526224550879604;140.3400617280421;125.73539481736796;gbtC;ABC-type transport system periplasmic substrate-binding protein (probable substrate glycine betaine);COG2113;ABC-type proline/glycine betaine transport system, periplasmic component;ProX;HELO_RS18615;E;gbtC; ABC-type transport system periplasmic substrate-binding protein (probable substrate glycine betaine);;gbtC;ABC-type transport system periplasmic substrate-binding protein (probable substrate glycine betaine);-1.063672089866655;0.05341007894216254;0.574854236768056;-1.3261474932313515;-0.26247540336469655
HELO_4389;89.43739749658262;43.33847339694012;94.00487237908821;100.5476309061251;98.6669409773853;90.25209617028356;0.8494393585602479;3.9882591158058034;14.89592647223346;15.52852003304929;7.574263622454958;4.597349285860178;HELO_4389;c-type cytochrome;COG3245;Cytochrome c5;CytC5;HELO_RS18625;C;;;;HELO_4389;c-type cytochrome;1.0283603783552948;0.058143805080224986;0.12725734958786106;-0.012938223230999135;-1.041298601586294
HELO_4390;82.41427871511439;85.43087655565671;72.96856987834893;77.26299628785772;52.438495169184876;68.34460006352346;3.422454151741902;5.294984572095231;4.853060734105422;7.758101579075233;2.6935557593989823;2.951478691081601;rep;ATP-dependent DNA helicase Rep;COG0210;Superfamily I DNA or RNA helicase;UvrD;HELO_RS18630;L;rep; ATP-dependent DNA helicase Rep;3.6.4.12;rep;ATP-dependent DNA helicase Rep;-0.05125242976164657;0.09312883997720789;-0.37590416073601673;0.2665108201534201;0.31776324991506666
HELO_4391;449.36901138775664;359.3964486802092;151.41886498334443;144.53255367851295;118.70942506614101;138.12258446115297;24.271512587171493;30.368962464840344;9.71851088758151;9.35314615988933;7.224772442303257;10.170630671794363;trmL;tRNA (cytidine(34)-2'-O)-methyltransferase TrmL;COG0219;tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain;TrmL;HELO_RS18635;J;trmL; tRNA (cytidine(34)-2'-O)-methyltransferase TrmL;2.1.1.207;trmL;tRNA (cytidine(34)-2'-O)-methyltransferase TrmL;0.3215227680739652;0.13168483844456702;-0.21681989448506123;1.694750924332065;1.3732281562581
HELO_4392;644.092861216066;502.352976066855;335.04296240340153;319.33992067674853;302.6275339406537;324.3261693015711;26.193221386331516;15.646679124706004;21.866823583644535;2.0123111604214814;5.559537705281299;7.435716592503478;HELO_4392;YfaZ domain protein;;;;;;;;;HELO_4392;YfaZ domain protein;0.35793640743424326;0.04675881267499982;-0.0995842527180919;0.9876199739346507;0.6296835665004075
HELO_4393;720.8959782714461;436.5289843021305;379.92335056599785;453.23054278609874;353.83942566939714;401.1412712035126;28.982622446809682;13.616149151935048;12.123780711620478;10.008337251375014;20.935628736357426;34.91859262221545;pyrE;orotate phosphoribosyltransferase;COG0461;Orotate phosphoribosyltransferase;PyrE;HELO_RS18645;F;pyrE; orotate phosphoribosyltransferase;2.4.2.10;pyrE;orotate phosphoribosyltransferase;0.7224123746065487;-0.07820167785298615;-0.1805360913383911;0.8440885611548907;0.121676186548342
HELO_4394;736.6068585087332;250.9109019428322;389.5947392867233;415.55286066259015;298.42277066767844;376.4224878772507;36.104958454094344;3.6812897513594374;14.744068948974537;14.54552199397503;15.315360215764452;25.671183441286196;xthA2;apurinic/apyrimidinic DNA endonuclease XthA;COG0708;Exonuclease III;XthA;HELO_RS18650;L;xthA2; apurinic/apyrimidinic DNA endonuclease XthA;3.1.11.2;xthA2;apurinic/apyrimidinic DNA endonuclease XthA;1.549938511571547;0.049492133195629506;-0.33399644483102087;0.9666716852118675;-0.5832668263596794
HELO_4395;229.54786529285707;273.69249626332385;407.9613414206003;273.6285075639448;324.89130506180936;342.9370259249354;7.096021750693043;6.801517064585399;27.516301928175633;18.736146143058335;40.93125616876236;9.073769944457386;rph;ribonuclease PH;COG0689;Ribonuclease PH;Rph;HELO_RS18655;J;rph; ribonuclease PH;2.7.7.56;rph;ribonuclease PH;-0.25275119355752285;0.24982003856410628;-0.07775357419154005;-0.5770781274826531;-0.32432693392513023
HELO_4396;124.99197341103485;69.3196456876479;135.7312465532955;131.48486088071326;156.70210343482748;137.62181432765365;8.24334858140565;4.4939574872928585;16.255131244555482;12.376455679677498;11.773996898477629;14.488442768125633;HELO_4396;UPF0701 family protein;COG1561;Uncharacterized stationary-phase protein YicC, UPF0701 family;YicC;HELO_RS18660;S;;rph;;HELO_4396;UPF0701 family protein;0.8413321202165998;-0.019811333164953204;0.1860475968142845;-0.13782247947705084;-0.9791545996936506
HELO_4397;145.10192924489752;146.99582923193626;449.6923885154306;433.19995419280093;740.3347276728223;462.6441730335173;13.08354653313453;4.814513832439495;21.329945151288896;48.14749221756673;9.423613164222308;13.527154025709846;panS;pantothenate precursor transport protein PanS;COG0385;Predicted Na+-dependent transporter YfeH;YfeH;HELO_RS18665;R;panS; pantothenate precursor transport protein PanS;;panS;pantothenate precursor transport protein PanS;-0.018581290138416584;-0.04087493818095567;0.6771070721301999;-1.6660427948447527;-1.6474615047063361
HELO_4398;772.8899698737978;531.3407746311381;654.0018612818972;767.8355585464832;710.0667623641081;664.8425067784814;4.687359417006429;17.987090332253178;10.59396613047868;16.434649718391782;29.157130358183316;24.75556805378943;HELO_4398;probable methyltransferase (homolog to DNA-cytosine methyltransferase);COG0270;DNA-cytosine methylase;Dcm;HELO_RS18675;L;;panS;2.1.1.37;HELO_4398;probable methyltransferase (homolog to DNA-cytosine methyltransferase);0.5397783877643008;-0.023681967472832355;0.09480404770789086;0.2169474877041413;-0.32283090006015946
HELO_4399;273.3162729921563;155.8205480308634;423.0138073425678;406.6292813547252;546.898780942368;347.302351014807;8.682903867885246;7.570446837583483;50.91341640392743;43.31866271543956;65.03783291191992;34.30092022102608;HELO_4399;uncharacterized protein;;;;;;;;;HELO_4399;uncharacterized protein;0.8067256016446542;0.2837710336066408;0.6535691826550956;-0.34450000274945225;-1.1512256043941065
HELO_4400;426.7042134471488;249.9929542551264;820.6559064234202;673.6146249329576;1296.5088614775289;755.6888844180615;17.61028982752979;8.997205658146525;46.777362660625634;32.64862902558149;78.54941797619509;48.29225286954941;HELO_4400;uncharacterized protein;;;;;;;;;HELO_4400;uncharacterized protein;0.7689665535688226;0.11883409520956434;0.7779722341118411;-0.823086832713086;-1.5920533862819086
HELO_4402;58.46235821842894;33.07149900512836;25.912411714575523;18.637483302408288;15.392526502347451;26.71446867415371;7.337389056677795;2.6656433704872797;1.4587083618116032;0.7784843653366401;2.1706263758503983;3.929751623344721;HELO_4402;major facilitator superfamily transport protein;COG2814;Predicted arabinose efflux permease AraJ, MFS family;AraJ;HELO_RS18705;G;;;;HELO_4402;major facilitator superfamily transport protein;0.8034112587920532;-0.04236766769185074;-0.7576011220535346;1.1013373308704963;0.2979260720784431
HELO_4403;166.40141009688514;230.44949454077206;203.23417029336397;168.09732192553508;170.88169092574242;215.44995161048374;1.4756631063206012;13.13320913044041;17.43799005898497;14.096524804785238;13.631475985694898;9.900824659705792;gmk;guanylate kinase;COG0194;Guanylate kinase;Gmk;HELO_RS18710;F;gmk; guanylate kinase;2.7.4.8;gmk;guanylate kinase;-0.4673857315477825;-0.08380921519181239;-0.33261760288241504;-0.37072179761715596;0.09666393393062656
HELO_4404;865.5958848052027;601.2843627459141;934.3204581802175;803.9542934077048;867.4020211811948;997.5935150158158;75.81196774637728;96.31304740598424;50.07648237754304;43.823737025188485;19.419163172042605;137.97095202765612;rpoZ;DNA-directed RNA polymerase omega subunit;COG1758;DNA-directed RNA polymerase, subunit K/omega;RpoZ;HELO_RS18715;K;rpoZ; DNA-directed RNA polymerase omega subunit;2.7.7.6;rpoZ;DNA-directed RNA polymerase omega subunit;0.5249145833471722;-0.09443679382337677;-0.20153445387754765;-0.2045381519512759;-0.7294527352984481
HELO_4405;437.66014444036165;317.2858944349078;239.99754104207804;206.35965802749004;218.7979946495117;253.94534340226141;12.690084723753905;9.491201216171776;4.911203683378853;3.437927640948521;12.18372451314353;8.392782684186672;spoT;bifunctional (p)ppGpp synthase/hydrolase SpoT;COG0317;(p)ppGpp synthase/hydrolase, HD superfamily;SpoT;HELO_RS18720;KT;spoT; bifunctional (p)ppGpp synthase/hydrolase SpoT;2.7.6.5,3.1.7.2;spoT;bifunctional (p)ppGpp synthase/hydrolase SpoT;0.4627804105909714;-0.08116956090954286;-0.21400976349828849;0.7829156453983472;0.3201352348073758
HELO_4406;403.5614789549367;573.5819306512116;483.68084647659265;185.90468015571298;390.93293814884373;445.00527636859056;15.543602252396296;30.782443675862403;17.027891163584385;3.2426437108790935;4.233045403557889;14.022370903172595;HELO_4406;RutC family protein;COG0251;Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family;RidA;HELO_RS18725;V;;spoT;;HELO_4406;RutC family protein;-0.506153666324618;0.11997429375180246;-0.18645395522516495;-0.14070182009090715;0.36545184623371085
HELO_4407;478.85349881871844;510.27495545875837;463.96976334006587;200.51636748010492;413.4919694659413;487.9073421103337;20.9692368224528;39.243569492730266;35.640080523277774;16.018291169917312;27.37928563523732;17.18597808339589;thpR;RNA 2'%2C3'-cyclic phosphodiesterase;COG1514;RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase);ThpR;HELO_RS18730;J;thpR; RNA 2',3'-cyclic phosphodiesterase;3.1.4.58;thpR;RNA 2'%2C3'-cyclic phosphodiesterase;-0.09150534555509182;-0.07242416920014172;-0.2382169203791662;-0.026967058492651574;0.06453828706244025
HELO_4408;321.47013355635573;217.70964232940074;470.2298285522872;427.453045541068;491.0998274514653;461.7934518121081;18.139190673944693;13.634884197074724;61.4973538743013;33.29020925642329;45.99736312938721;27.806835369871497;HELO_4408;uncharacterized protein;COG0451;Nucleoside-diphosphate-sugar epimerase;WcaG;HELO_RS18735;M;;thpR;;HELO_4408;uncharacterized protein;0.5601487212248575;0.026062412235914323;0.08858255909232504;-0.5212029038933714;-1.081351625118229
HELO_4409;400.69116550965026;108.06428907984015;264.40701551664944;206.00375162548036;256.0304518033417;279.62599164189606;4.926923533655233;1.147274932289473;28.296078166339097;7.251538415598019;15.749692297657209;25.52038628643443;HELO_4409;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS18740;K;;;;HELO_4409;LysR family transcription regulator;1.8809079348499624;-0.08044213184168392;-0.126709344365743;0.5174380943109718;-1.3634698405389907
HELO_4410;208.71914990619953;78.07687448387189;156.88493389311307;140.06391523518096;164.87918991720457;163.3707750758941;10.200777283111488;2.299942584241311;7.828653035088946;6.9674137310990565;5.635968167467536;11.409834048314881;recG;ATP-dependent DNA helicase RecG;COG1200;RecG-like helicase;RecG;HELO_RS18745;L;recG; ATP-dependent DNA helicase RecG;3.6.4.12;recG;ATP-dependent DNA helicase RecG;1.4071308482969478;-0.05808030322798974;0.013179094475144204;0.35150479063853;-1.0556260576584178
HELO_4411;24.26891038381413;30.417819010335307;20.045279803662556;19.62485925451328;24.25310401439592;20.732423305411995;0.3767884187395598;1.3281825628008452;1.9311204416648329;0.12879510596831678;1.3582373802301382;1.4553016310478253;HELO_4411;YccS family protein;COG1289;Uncharacterized membrane protein YccC;YccC;HELO_RS18750;S;;;;HELO_4411;YccS family protein;-0.31421957841283543;-0.046352362399803226;0.21661167599412323;0.21751440213399587;0.5317339805468313
HELO_4412;496.28452426558835;337.4448099819894;235.5869329510796;215.32199485548665;325.46632411004987;255.25103276245525;12.09190843296061;29.236491331792717;24.541514927121984;18.186903735227023;43.427210030821826;36.00179544851269;HELO_4412;uncharacterized protein;;;;;;;;;HELO_4412;uncharacterized protein;0.5551509410184323;-0.11518742540860583;0.3493763624369013;0.9565137153838972;0.40136277436546486
HELO_4413;2612.9924203916253;2181.1640504174466;4982.703983102986;4709.916514077145;6632.629582266386;4946.522401122238;47.85922828148964;199.1407787384394;244.0747906826832;50.367267852184945;171.1069877180492;42.10838910641869;hupB3;HU-type DNA-binding protein HupB;COG0776;Bacterial nucleoid DNA-binding protein IHF-alpha;HimA;HELO_RS18760;L;hupB3; HU-type DNA-binding protein HupB;;hupB3;HU-type DNA-binding protein HupB;0.2604953933985623;0.010512139754613514;0.4230922157412813;-0.9204512815845884;-1.1809466749831508
HELO_4414;171.1666523570951;193.69313267640416;367.54915656904353;349.8859492072793;282.9202975099627;362.3460299064782;8.63775838633274;5.343458023861241;5.69387136532029;6.0003226514705705;11.749503957843293;4.550834439571983;rubB;rubredoxin--NAD reductase;COG1251;NAD(P)H-nitrite reductase, large subunit;NirB;HELO_RS18765;C;rubB; rubredoxin--NAD reductase;1.18.1.1;rubB;rubredoxin--NAD reductase;-0.1773962689600923;0.020512913964850554;-0.355858151567233;-1.077538414368159;-0.9001421454080667
HELO_4415;115.89573443817885;104.84111877622969;100.32565796110343;96.21264616348158;90.25190383448421;101.91822831167184;2.2453566241869467;2.565220905528799;8.175662593092165;2.260322937938228;1.1426326052701234;3.635456540395984;ubiA;4-hydroxybenzoate octaprenyltransferase;COG0382;4-hydroxybenzoate polyprenyltransferase;UbiA;HELO_RS18775;H;ubiA; 4-hydroxybenzoate octaprenyltransferase;2.5.1.39;ubiA;4-hydroxybenzoate octaprenyltransferase;0.14332206985616747;-0.02249898349214252;-0.1735719631086896;0.18372375934841756;0.04040168949225009
HELO_4416;158.2868258422395;87.26742402550587;118.21531187373182;113.39601013055345;116.73979466918907;114.90150824598054;6.9147290884265376;1.7689007541857478;6.683680430642241;9.910910499188452;5.6956258774859;9.08763026077043;phoB;response regulator/HTH domain transcription regulator PhoB;COG0745;DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain;OmpR;HELO_RS18780;KT;phoB; response regulator/HTH domain transcription regulator PhoB;;phoB;response regulator/HTH domain transcription regulator PhoB;0.8516739504186104;0.04067020524470699;0.022702676294155566;0.458727610115238;-0.3929463403033724
HELO_4417;40.59065752869355;31.139905319484342;19.172332626306936;19.81201378147725;19.708861057696996;17.283979681785773;0.6723561846142689;1.3316820219085;1.7372312247244035;2.4473755581452417;1.6798085014763393;2.287275656826391;phoR;PAS domain protein / sensor histidine kinase PhoR;COG5002;Sensor histidine kinase WalK;WalK;HELO_RS18785;T;phoR; PAS domain protein / sensor histidine kinase PhoR;2.7.13.3;phoR;PAS domain protein / sensor histidine kinase PhoR;0.3718938144898978;0.14179779869027076;0.17966808980237214;1.1856793726437864;0.8137855581538886
HELO_4418;107.62637762257133;50.992356561175974;74.92248758866894;56.97895325863529;53.81536937607218;82.44421705569965;3.6160512149202306;0.6220822320265337;3.0776567300537248;3.2251135292972273;3.3951419410785215;3.134314361009446;cysZ;CysZ family transport protein (probable substrate sulfate);COG2981;Sulfate transporter CysZ;CysZ;HELO_RS18790;EP;cysZ; CysZ family transport protein (probable substrate sulfate);;cysZ;CysZ family transport protein (probable substrate sulfate);1.0630030215398252;-0.13628480697440004;-0.6062316106582406;0.3804904988153295;-0.6825125227244957
HELO_4419;120.25580441113345;44.82450496916483;76.56346251143458;59.4166710829379;76.06826229716243;74.53762923881472;1.77510336475947;1.9801417472439495;1.9063534223550047;0.20754942126572715;6.205251615493231;4.603023235866048;phoU;regulator protein PhoU;COG0704;Phosphate uptake regulator PhoU;PhoU;HELO_RS18795;P;phoU; regulator protein PhoU;;phoU;regulator protein PhoU;1.4038626086413535;0.03818170298604695;0.028941356781872152;0.6827863991493119;-0.7210762094920415
HELO_4420;73.77934781763007;33.98246478073331;36.62805075801101;30.304513958923465;37.37273749337347;40.55933816038879;1.6443282019911876;0.5319746122952062;1.7274645305876875;1.1378414329010553;0.8420386078062926;3.836316990285545;pstB;ABC-type transport system ATP-binding protein (probable substrate phosphate);COG1117;ABC-type phosphate transport system, ATPase component;PstB;HELO_RS18800;P;pstB; ABC-type transport system ATP-binding protein (probable substrate phosphate);7.3.2.1;pstB;ABC-type transport system ATP-binding protein (probable substrate phosphate);1.09600794721635;-0.14336412369754203;-0.11509098944821528;0.8474672096380536;-0.24854073757829642
HELO_4421;42.406410459958124;23.014528038381723;20.857222887455304;22.126076426545225;21.701433503522296;20.0512559036712;4.16603119353722;1.2666347747409883;0.9661190277541438;1.8282541831122712;1.1345154624989653;2.9585205528588787;pstA;ABC-type transport system permease protein (probable substrate phosphate);COG4985;ABC-type phosphate transport system, auxiliary component PstA;PstA;HELO_RS18805;P;pstA; ABC-type transport system permease protein (probable substrate phosphate);;pstA;ABC-type transport system permease protein (probable substrate phosphate);0.8540006669753142;0.05420380212288567;0.10887709466919748;1.0440018162290228;0.1900011492537086
HELO_4422;59.55751144681894;31.212507849670768;28.946608157055323;30.611800402896325;28.441554135132787;26.54746444621217;3.096021537210383;1.3153355815573846;1.2494483279494617;2.309631235999197;1.2878049066344515;3.5893888979722313;pstC;ABC-type transport system permease protein (probable substrate phosphate);COG4590;ABC-type uncharacterized transport system, permease component;;HELO_RS18810;R;pstC; ABC-type transport system permease protein (probable substrate phosphate);;pstC;ABC-type transport system permease protein (probable substrate phosphate);0.9106849367183676;0.12047307349023928;0.09593429433931266;1.1363863855691596;0.22570144885079202
HELO_4423;167.32425037969816;81.61936733676406;132.2579285370121;140.79354642994772;155.16988269883697;135.28231946854712;3.060231396564262;2.7340432183919385;4.945212900768733;9.728644540248112;7.866174759126118;5.521038406071386;pstS;ABC-type transport system periplasmic substrate-binding protein (probable substrate phosphate);COG0226;ABC-type phosphate transport system, periplasmic component;PstS;HELO_RS18815;P;pstS; ABC-type transport system periplasmic substrate-binding protein (probable substrate phosphate);;pstS;ABC-type transport system periplasmic substrate-binding protein (probable substrate phosphate);1.0266911220845643;-0.032377034287279116;0.19651785029930124;0.30464463307441836;-0.7220464890101459
HELO_4424;127.43002987723884;71.55450570588755;223.20676132035817;213.98485411096303;145.1786013793692;236.44652253937485;6.778478528387798;6.000563477661812;26.98812702422603;13.60703386193793;4.796276541073076;18.858030578825343;HELO_4424;thioesterase domain protein;COG1607;Acyl-CoA hydrolase;YciA;HELO_RS18820;I;;pstS;3.1.2.-;HELO_4424;thioesterase domain protein;0.8238454620269637;-0.08277284212000335;-0.6998704925328241;-0.8866200507508895;-1.7104655127778532
HELO_4425;362.94971550423685;161.6112274985207;470.054050964349;409.0961747898845;588.9466342770694;471.7013495026372;10.996782124345135;2.5981276975179974;43.30165910127901;10.199013877369078;64.92447808722167;46.724817931951804;HELO_4425;TRAP transporter substrate-binding protein (probable substrate pyruvate/small keto acid);COG4663;TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component;FcbT1;HELO_RS18825;Q;;;;HELO_4425;TRAP transporter substrate-binding protein (probable substrate pyruvate/small keto acid);1.162312264889695;-0.005036372442271286;0.31965547284648643;-0.3771898467377621;-1.5395021116274572
HELO_4426;110.6499410222138;112.99090859111226;163.9611198040682;160.39131536961727;182.6722971705299;161.9504526239593;2.6179743681793055;4.835176416284919;9.519862943046954;4.922309472275283;16.437004483551252;14.787335039770937;uvrD;DNA-dependent helicase II;COG0210;Superfamily I DNA or RNA helicase;UvrD;HELO_RS18830;L;uvrD; DNA-dependent helicase II;3.6.4.12;uvrD;DNA-dependent helicase II;-0.029936276951916696;0.01769267186055945;0.17270068537713978;-0.5454508703512886;-0.5155145933993719
HELO_4427;195.0693047321082;118.11149682456812;251.22088376892032;256.737030864779;210.49776852124754;248.30257455658878;4.810800205144996;6.856010778002581;14.897529304155563;4.951462329101902;17.092695654882657;17.910311962115337;HELO_4427;RpiR family transcription regulator;COG1737;DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains;RpiR;HELO_RS18835;K;;uvrD;;HELO_4427;RpiR family transcription regulator;0.7190510236865411;0.016789953403776536;-0.23725533988608305;-0.34653408691958365;-1.0655851106061247
HELO_4428;188.37120845663358;45.50695759814388;196.53903345420375;227.7637739372578;346.1062546030639;166.5013543291736;33.06144854806585;11.39638359928107;25.45004787328107;21.24549715582464;60.16252542336036;22.080276074466436;HELO_4428;uncharacterized protein;;;;;;;;;HELO_4428;uncharacterized protein;2.0256985340556195;0.23796499560631368;1.0512046012172442;0.1770442430902195;-1.8486542909654
HELO_4429;530.1572866781845;725.9087182246288;665.9351852040636;840.2986472136755;467.3298050495952;639.9002849278462;33.32921307795938;35.220302342950106;35.87515889855873;10.958473661575658;18.171679042192576;29.975687732513858;HELO_4429;NSS family transport protein;COG0733;Na+-dependent transporter, SNF family;YocR;HELO_RS18845;R;;;;HELO_4429;NSS family transport protein;-0.45263507247692836;0.05744665147456196;-0.4525750555052621;-0.27096077505294147;0.18167429742398689
HELO_4430;157.45023936592386;93.7075024017754;94.38086465948845;93.07379751468211;70.05641349087013;94.70429587056975;16.55190565993432;13.62276022641169;12.876171570361823;12.063239408771775;6.444210377603025;16.412541589885763;HELO_4430;UPF0759 family protein;COG1801;Sugar isomerase-related protein YecE, UPF0759/DUF72 family;YecE;HELO_RS18850;R;;;;HELO_4430;UPF0759 family protein;0.7424792184973024;-0.004883822988682951;-0.42961881253338685;0.7273742497503211;-0.015104968746981307
HELO_4431;109.37685790554157;31.916881736791932;56.579637837537376;58.926544266833254;66.25321887086244;56.52853394983246;15.224222488104578;8.572446515232349;2.4877588037812095;4.964739034768913;16.66872331801822;4.4950726911517895;nrdH;glutaredoxinlutaredoxin-like protein NrdH-like protein NrdH;COG0695;Glutaredoxin;GrxC;HELO_RS18855;O;nrdH; glutaredoxinlutaredoxin-like protein NrdH-like protein NrdH;;nrdH;glutaredoxinlutaredoxin-like protein NrdH-like protein NrdH;1.7455381432895747;0.0012810094897899305;0.22532561430837905;0.9400881117353785;-0.8054500315541961
HELO_4432;208.41026303948593;64.45987494900918;43.6373551175889;43.52057051225595;42.69090209124317;49.245871391553045;4.598868623433619;1.0488994633217399;3.7007035266007833;3.8855805928607086;4.068280711819869;11.08709365132632;nrdI;ribonucleotide reductase maintenance protein NrdI;COG1780;Flavodoxin NrdI, NrdF-interacting activator of class Ib ribonucleotide reductase;NrdI;HELO_RS18860;F;nrdI; ribonucleotide reductase maintenance protein NrdI;;nrdI;ribonucleotide reductase maintenance protein NrdI;1.67764939794856;-0.1707535114637766;-0.2016721640466992;2.0592551866554407;0.38160578870688067
HELO_4433;222.7168921801866;120.1974806001492;132.07709204329328;154.69514381203706;117.34681081736646;140.84249932673583;16.073581143527836;1.98122906346372;15.90642768722681;8.932935221486416;2.444755269625904;22.4921897410784;nrdE;ribonucleotide-diphosphate reductase alpha subunit;COG0209;Ribonucleotide reductase alpha subunit;NrdA;HELO_RS18865;F;nrdE; ribonucleotide-diphosphate reductase alpha subunit;1.17.4.1;nrdE;ribonucleotide-diphosphate reductase alpha subunit;0.8843144849987103;-0.09202761610756038;-0.2612690333071317;0.6573843315227457;-0.22693015347596468
HELO_4434;264.2051763810486;123.2255572503207;150.05033161793074;154.05245709514813;121.65347832561243;161.98471875577513;22.70739022524655;5.638463611935929;16.49677249555365;5.995754014274182;9.064191494844417;31.584099887728133;nrdF;ribonucleotide-diphosphate reductase beta subunit;COG0208;Ribonucleotide reductase beta subunit, ferritin-like domain;NrdB;HELO_RS18870;F;nrdF; ribonucleotide-diphosphate reductase beta subunit;1.17.4.1;nrdF;ribonucleotide-diphosphate reductase beta subunit;1.0941469212900081;-0.10970735412558685;-0.41014855769421654;0.7023722293189927;-0.39177469197101544
HELO_4435;308.5044659162431;180.70944152258951;232.3072385056848;230.75407643238256;214.52715497184727;231.93673760887063;16.43678451249308;7.247818429711745;10.448014237590481;3.2651927310773203;7.565032417432157;8.621764770219057;glmS;glutamine--fructose-6-phosphate aminotransferase (isomerizing);COG0449;Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains;GlmS;HELO_RS18875;M;glmS; glutamine--fructose-6-phosphate aminotransferase (isomerizing);2.6.1.16;glmS;glutamine--fructose-6-phosphate aminotransferase (isomerizing);0.7683268434321402;0.002292876461135407;-0.11206854145043366;0.4100220345041974;-0.3583048089279428
HELO_4436;264.87924789012186;216.10897568039684;258.2802432635638;247.80955123067898;228.8412810126089;272.186681542965;17.1794016821942;9.599830746311891;12.153585620330807;5.725968965483354;2.1383785134437114;13.218823219679676;glmU;UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase;COG1207;Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase;GlmU;HELO_RS18880;M;glmU; UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase;2.7.7.23,2.3.1.157;glmU;UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase;0.29235180714292497;-0.07537487141370391;-0.2492492119397589;-0.03911597278831991;-0.3314677799312449
HELO_4437;130.61213153793335;90.55497415523543;172.27838873885625;114.22963628297923;152.9893637831598;150.73175064212526;8.940622084037997;8.581445925380333;14.632758219802694;6.838332373891534;18.19242212085771;18.496451952087895;apbE;FAD:protein FMN transferase;COG1477;FAD:protein FMN transferase ApbE;ApbE;HELO_RS18885;OH;apbE; FAD:protein FMN transferase;2.7.1.180;apbE;FAD:protein FMN transferase;0.5235823032290163;0.19156872448907514;0.021307697342842324;-0.20523053076813813;-0.7288128339971545
HELO_4438;228.36492591368426;228.00723141033146;146.43273336672314;136.26753618606097;125.90861769200279;139.9335070478607;6.592726204371719;12.444851962330654;7.0933430612857755;1.2165371376768204;7.715623394626147;7.944246106544011;uppP;undecaprenyl-diphosphatase;COG1968;Undecaprenyl pyrophosphate phosphatase;UppP;HELO_RS18890;I;uppP; undecaprenyl-diphosphatase;3.6.1.27;uppP;undecaprenyl-diphosphatase;0.002251638467322792;0.06504221632124896;-0.15122461598155557;0.702630139533448;0.7003785010661252
HELO_4439;202.99115308237853;105.18144795288855;175.81410049666445;190.5130121629578;182.67473142626912;174.06823417871308;7.1629140318674995;1.6315369455502633;14.892716439994253;12.28152175678089;16.396439902309485;12.877992022822337;HELO_4439;MgtE family transport protein;COG2239;Mg/Co/Ni transporter MgtE (contains CBS domain);MgtE;HELO_RS18895;P;;uppP;;HELO_4439;MgtE family transport protein;0.9419748649838935;0.014315997699927863;0.06923583202453987;0.22058925207760538;-0.7213856129062881
HELO_4440;82.05361529013427;48.464960887279744;56.38716661562798;55.666566915537146;50.49212262841143;53.22663833370931;3.6602111130197676;5.799948728874713;6.813713014389974;8.310141989373237;5.620266728390882;9.29877359914909;HELO_4440;MarR family transcription regulator;COG1846;DNA-binding transcriptional regulator, MarR family;MarR;HELO_RS18900;K;;;;HELO_4440;MarR family transcription regulator;0.7476360332621663;0.08172640950214927;-0.07464999358297675;0.6150412332003778;-0.13259480006178848
HELO_4441;7.822650848361513;29.779723673304314;4.237399801292563;3.84802142296621;3.7240551399273385;4.852814134577893;0.5478189411884274;0.6923441094815301;0.3674373817003846;0.6945300945752816;1.0601478919750624;0.6683160862759959;HELO_4441;major facilitator superfamily transport protein;;;;;;;;;HELO_4441;major facilitator superfamily transport protein;-1.8026961825365762;-0.1602797259968285;-0.30910466011916204;0.592081727879572;2.394777910416148
HELO_4442;3.4500586914258435;21.250418476818187;5.46398546519094;4.948839514677265;4.526990017932447;6.247940237656164;0.3356229337198845;0.5392382847548319;0.985629809297206;0.7839878560374955;0.2972716254837249;0.5982407042031195;HELO_4442;RND family transport protein MFP component;COG1566;Multidrug resistance efflux pump EmrA;EmrA;HELO_RS18910;V;;;;HELO_4442;RND family transport protein MFP component;-2.3219362010626328;-0.16514710572665114;-0.39107705283746874;-0.7037466960198886;1.6181895050427442
HELO_4443;1840.744752073411;2917.061671557321;1176.6647951075217;756.1193453103375;1555.9387722895128;1100.5114498421892;82.20641322606852;271.90182517903713;63.119567208486046;30.610912195190803;97.85838294319046;223.86778237624324;atpC;F0F1-type ATP synthase epsilon subunit;COG0355;FoF1-type ATP synthase, epsilon subunit;AtpC;HELO_RS18915;C;atpC; F0F1-type ATP synthase epsilon subunit;;atpC;F0F1-type ATP synthase epsilon subunit;-0.66393724234009;0.09644446431285303;0.49922771908900465;0.7415886403209786;1.4055258826610686
HELO_4444;1513.751678950368;2728.4241543071166;2644.157943804312;2027.3259094738578;4209.583585132576;2627.1965007859485;33.084657487920644;98.37921130508514;316.8348242317818;294.53089284105977;480.42341858554107;152.99411553708933;atpD;F0F1-type ATP synthase beta subunit;COG0055;FoF1-type ATP synthase, beta subunit;AtpD;HELO_RS18920;C;atpD; F0F1-type ATP synthase beta subunit;7.1.2.2,7.2.2.1;atpD;F0F1-type ATP synthase beta subunit;-0.8495153031427591;0.00928072420393633;0.6799470592775876;-0.7949918401560474;0.054523462986711735
HELO_4445;1227.0741597373421;3569.778365310712;1988.1021376270373;1505.9608335703767;2783.6797300442445;1985.1116275773022;58.8095533849566;200.83707704392782;69.25886694641133;125.49966565442149;75.28884559739177;14.31943499218783;atpG;F0F1-type ATP synthase gamma subunit;COG0224;FoF1-type ATP synthase, gamma subunit;AtpG;HELO_RS18925;C;atpG; F0F1-type ATP synthase gamma subunit;;atpG;F0F1-type ATP synthase gamma subunit;-1.5398409066542644;0.002170647963708916;0.4875647002154988;-0.6935490271017102;0.8462918795525542
HELO_4446;1458.0066591362345;2724.155158146387;2635.320567667149;2070.8603343420937;4488.638872803954;2635.8270988150875;64.5060063091661;123.49519750991557;330.60715861933994;313.48902362407887;495.9553586556565;222.48576590447638;atpA;F0F1-type ATP synthase alpha subunit;COG0056;FoF1-type ATP synthase, alpha subunit;AtpA;HELO_RS18930;C;atpA; F0F1-type ATP synthase alpha subunit;7.1.2.2,7.2.2.1;atpA;F0F1-type ATP synthase alpha subunit;-0.9013519048728842;-0.0002771665136869217;0.7677964310984748;-0.8538165064068597;0.0475353984660245
HELO_4447;1347.397111380152;2270.511413271231;1025.6087726680098;778.018065003118;1797.338462747037;1122.7684854286301;51.404112515634914;84.27892656513352;130.21425782754008;129.98926509867505;125.95160760029289;60.88936477845971;atpH;F0F1-type ATP synthase delta subunit;COG0712;FoF1-type ATP synthase, delta subunit;AtpH;HELO_RS18935;C;atpH; F0F1-type ATP synthase delta subunit;;atpH;F0F1-type ATP synthase delta subunit;-0.7524071124662068;-0.13045835358665592;0.6783197264618117;0.26290059426174395;1.0153077067279508
HELO_4448;2073.303599263995;4913.120861480399;1900.958601798402;1519.5408769313842;2885.222154202756;1677.4669416223394;159.66678632758578;416.7549133345903;52.781710364420775;60.377630797634794;75.60015758997787;134.36563662957187;atpF;F0F1-type ATP synthase subunit b;COG0711;FoF1-type ATP synthase, membrane subunit b or b';AtpF;HELO_RS18940;C;atpF; F0F1-type ATP synthase subunit b;;atpF;F0F1-type ATP synthase subunit b;-1.2443062754677392;0.18034172210886368;0.7820382265801253;0.3054829427634136;1.5497892182311528
HELO_4449;1209.5703779831545;2315.16879093539;1040.2289048573791;716.0668976125777;1318.182864698889;814.5165220857724;45.97821044121076;329.6538808729461;250.92357655550484;21.20433826270531;281.6251253685988;148.96641107187907;atpE;F0F1-type ATP synthase subunit c;COG0636;FoF1-type ATP synthase, membrane subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K;AtpE;HELO_RS18945;C;atpE; F0F1-type ATP synthase subunit c;;atpE;F0F1-type ATP synthase subunit c;-0.9360534390352058;0.35250125624622264;0.6938585535143353;0.5699009437541775;1.5059543827893833
HELO_4450;625.8537256143378;954.5991015639603;599.1138401397789;485.67087768387665;921.6969091464917;589.3851216485555;11.921952063636589;27.60784100771093;27.53675415751969;30.959214802458728;43.53497386155419;37.81206574798337;atpB;F0F1-type ATP synthase subunit a;COG0356;FoF1-type ATP synthase, membrane subunit a;AtpB;HELO_RS18950;C;atpB; F0F1-type ATP synthase subunit a;;atpB;F0F1-type ATP synthase subunit a;-0.6082766635445314;0.023579838070094894;0.6442004595860222;0.08647246949413478;0.6947491330386661
HELO_4451;344.03706817172684;335.5295088245934;223.131091236306;215.9765419928191;184.60539446836165;175.97348792647426;53.09549933750784;30.115716456041465;28.33642374893617;29.907540305610297;21.9662000580136;34.78845654759474;atpI;ATP synthase c-ring assembly chaperone AtpI;COG3312;FoF1-type ATP synthase accessory protein AtpI;AtpI;HELO_RS18955;C;atpI; ATP synthase c-ring assembly chaperone AtpI;;atpI;ATP synthase c-ring assembly chaperone AtpI;0.036018348352756746;0.34080954291622234;0.06870539282300303;0.9632181134570104;0.9271997651042536
HELO_4452;568.0093421843741;488.3437173521788;334.5106256254497;357.07698686480825;341.6426445891271;307.84027974526896;7.837007922348055;30.5038759819329;5.6470214432907015;15.263749996285192;11.622269047307025;16.719926882650842;parB;chromosome partitioning protein ParB;COG1475;Chromosome segregation protein Spo0J, contains ParB-like nuclease domain;Spo0J;HELO_RS18960;D;parB; chromosome partitioning protein ParB;;parB;chromosome partitioning protein ParB;0.21760416228377188;0.11949753243509242;0.14984379253032465;0.8815914144899164;0.6639872522061445
HELO_4453;651.1712523722075;573.871377233635;322.94947050881234;354.47145291459327;371.2488661036588;357.8513734165397;9.20135233716741;22.39942807687642;6.715965167911941;16.543006063390546;17.734181414119135;11.424351048901679;parA;chromosome partitioning protein ParA;COG1192;ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ;ParA;HELO_RS18965;DN;parA; chromosome partitioning protein ParA;;parA;chromosome partitioning protein ParA;0.18201164771670264;-0.14761764254413556;0.05288101197757378;0.8618644063842567;0.679852758667554
HELO_4454;493.1277859192132;502.0599261963659;355.5797193868732;417.1459406939935;367.46469999048924;336.98249626061096;20.984977930137003;31.564474985420535;9.72624318430454;23.84081717719042;16.990439148653;7.664139702398538;rsmG;16S rRNA (guanine(527)-N(7))-methyltransferase RsmG;COG0357;16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B);RsmG;HELO_RS18970;J;rsmG; 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG;2.1.1.170;rsmG;16S rRNA (guanine(527)-N(7))-methyltransferase RsmG;-0.0258460849099702;0.07727611858016736;0.12457787862019565;0.547935651197804;0.5737817361077742
HELO_4455;310.17014311080396;177.5996051816741;223.9746718931425;269.16160196973686;245.8059920083609;233.50311745960974;6.510936259775625;3.239315253171552;9.01024283648489;13.895109477019895;20.065123891911746;15.416740795014146;mnmG;tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG;COG0445;tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA;MnmG;HELO_RS18975;J;mnmG; tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG;;mnmG;tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG;0.8009747486549683;-0.05984451286534398;0.07377031906630727;0.4080965379439645;-0.3928782107110038
HELO_4456;80.42202940346202;107.3566217626634;150.58795592197544;120.04995200971918;144.8583572417102;162.5256497354145;6.433642917785835;3.215454377325673;1.0233653646199372;8.687322207924693;5.45241417633935;16.665241914626463;glnQ;ABC-type transport system ATP-binding protein (probable substrate glutamine);COG1126;ABC-type polar amino acid transport system, ATPase component;GlnQ;HELO_RS18980;E;glnQ; ABC-type transport system ATP-binding protein (probable substrate glutamine);7.4.2.1;glnQ;ABC-type transport system ATP-binding protein (probable substrate glutamine);-0.41229623491843714;-0.10936181470180983;-0.1649488960375729;-1.006025861201472;-0.5937296262830349
HELO_4457;56.63941116593772;85.19169568437358;104.20823451292733;81.86230524900566;116.87445695911383;129.29628538787702;4.356914480022534;2.926109773998668;5.587787726837743;10.924949055573517;7.357787508386194;1.103636729416684;glnP;ABC-type transport system permease protein (probable substrate glutamine);COG0765;ABC-type amino acid transport system, permease component;HisM;HELO_RS18985;E;glnP; ABC-type transport system permease protein (probable substrate glutamine);;glnP;ABC-type transport system permease protein (probable substrate glutamine);-0.580493279328822;-0.3085483278202066;-0.14454483024910125;-1.1766684523687871;-0.5961751730399651
HELO_4458;488.27415031595996;712.1958823932296;1079.734474860399;875.3109069686872;1049.5010396209348;1174.4041807736785;37.86723397327507;30.890830969694985;122.3111933691948;34.911965856733495;31.94424228478318;156.68609606595624;glnH;ABC-type transport system periplasmic substrate-binding protein (probable substrate glutamine);COG0834;ABC-type amino acid transport/signal transduction system, periplasmic component/domain;HisJ;HELO_RS18990;TE;glnH; ABC-type transport system periplasmic substrate-binding protein (probable substrate glutamine);;glnH;ABC-type transport system periplasmic substrate-binding protein (probable substrate glutamine);-0.5436553103654553;-0.12114482339477739;-0.16207934517945688;-1.2644419665497733;-0.7207866561843179
HELO_4459;236.57583842668905;203.6390414255111;230.73265278561243;171.0011627983839;215.05601537183406;211.31829767606175;5.958947600871417;13.562028195548107;6.337522130689434;5.859750844321719;12.456870284641818;14.83489862845864;erpA;iron-sulfur cluster insertion protein ErpA;COG0316;Fe-S cluster assembly iron-binding protein IscA;IscA;HELO_RS18995;O;erpA; iron-sulfur cluster insertion protein ErpA;;erpA;iron-sulfur cluster insertion protein ErpA;0.2153067093964678;0.1262326359216246;0.02517668996476985;0.16215941220369245;-0.053147297192775333
HELO_4460;452.28302357811145;392.89203205925145;603.0856996405715;596.8798108980627;808.812836354915;651.6468546782045;1.1598964504340876;11.61253515405721;70.84780476928869;41.76810483200053;72.21930914403814;50.43398669177792;argC;N-acetyl-gamma-glutamyl-phosphate reductase;COG0002;N-acetyl-gamma-glutamylphosphate reductase;ArgC;HELO_RS19000;E;argC; N-acetyl-gamma-glutamyl-phosphate reductase;1.2.1.38;argC;N-acetyl-gamma-glutamyl-phosphate reductase;0.2026118968709696;-0.1115493303458237;0.3112859465853113;-0.5258904345794821;-0.7285023314504517
HELO_4461;71.09244380764949;44.25310202303904;69.37155469051237;72.90745939776035;72.60868184957259;71.47566668210035;4.195017222786585;0.5101465763974536;7.338410293321346;3.6971243120676145;2.3402277351639755;3.8549873582226115;clcB2;ClC-type chloride channel ClcB;COG0038;H+/Cl- antiporter ClcA;ClcA;HELO_RS19005;P;clcB2; ClC-type chloride channel ClcB;;clcB2;ClC-type chloride channel ClcB;0.6718313649819132;-0.04250431302000912;0.02237923715662138;-0.007648644415929162;-0.6794800093978424
HELO_4462;113.19549330889345;109.44526389999577;57.630867241267445;60.78041317774329;59.88907880733746;65.72778001239989;3.54909768153178;5.797346673974985;9.58864607787365;6.599834037101001;8.352469036388547;1.634587418174517;HELO_4462;UPF0093 family protein;COG1981;Protoporphyrinogen oxidase HemJ (unrelated to HemG or HemY);HemJ;HELO_RS19010;H;;clcB2;1.3.99.-;HELO_4462;UPF0093 family protein;0.04817416174326361;-0.1866271105874331;-0.13210402064018023;0.7751463040096711;0.7269721422664075
HELO_4463;226.49567000087282;174.80611027323394;179.34870342122792;160.6975125585656;168.37000195472464;172.4135402864339;4.776435371445296;22.768887439911563;4.553960851343802;3.7755758623349704;5.953316285128509;6.108815946937451;HELO_4463;probable kinase (homolog to phosphomethylpyrimidine kinase);COG0351;Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase;ThiD;HELO_RS19015;H;;;2.7.1.49,2.7.4.7;HELO_4463;probable kinase (homolog to phosphomethylpyrimidine kinase);0.37185387298740036;0.05657250131816394;-0.034038176189689295;0.39162253639396827;0.01976866340656791
HELO_4464;305.1237304740256;209.59161793390572;386.66854896210475;309.24247233029837;449.4437598639699;380.23749216931037;6.25853199883018;9.170780718915127;28.744388249088804;13.873335809072909;53.41306497700339;33.71130562311806;hemL;glutamate-1-semialdehyde 2%2C1-aminomutase;COG0001;Glutamate-1-semialdehyde aminotransferase;HemL;HELO_RS19020;H;hemL; glutamate-1-semialdehyde 2,1-aminomutase;5.4.3.8;hemL;glutamate-1-semialdehyde 2%2C1-aminomutase;0.5396668711164114;0.024133690213984593;0.24065698397880375;-0.316575119877589;-0.8562419909940004
HELO_4465;248.72590575349867;172.66088297434942;259.14596391374084;230.0668401438741;333.1067632335535;266.0427748095222;0.6733196442152989;5.925679644119807;20.723011444202054;18.510864735385233;28.84891899925901;20.53925676322359;HELO_4465;uncharacterized protein;COG0645;Predicted kinase, contains AAA domain;;HELO_RS19025;R;;hemL;;HELO_4465;uncharacterized protein;0.5240726652048879;-0.03774952625329142;0.32323833629446064;-0.09672536124054965;-0.6207980264454376
HELO_4466;182.2716023211183;141.33938376687664;124.40358209739624;119.0783969371344;149.52617168857216;137.0077896149545;10.258420502295008;2.8942315230185565;10.964904719953545;11.389724349449038;11.36773481026193;5.944909648028537;rdgB;non-canonical purine NTP pyrophosphatase RdgB;COG0127;Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family;RdgB;HELO_RS19030;F;rdgB; non-canonical purine NTP pyrophosphatase RdgB;3.6.1.66;rdgB;non-canonical purine NTP pyrophosphatase RdgB;0.3646483644112051;-0.1381711411004325;0.12526464756566913;0.40923355984329923;0.04458519543209416
HELO_4467;119.97339164851495;99.75035842708128;92.79825579501816;88.14442622007346;108.70719421185011;93.65610133053288;1.6774624547577284;8.628321952117249;9.723297964535105;6.78262856713968;5.1850157375378565;9.177280450447983;yggW;HemN family protein YggW;COG0635;Coproporphyrinogen-III oxidase HemN  (oxygen-independent) or related Fe-S oxidoreductase;HemN;HELO_RS19035;H;yggW; HemN family protein YggW;;yggW;HemN family protein YggW;0.26390478732951994;-0.013134406303911383;0.21289072862260827;0.35392235150343687;0.09001756417391693
HELO_4468;490.20104356601206;184.35637820432098;500.80287354054616;359.8551649046085;526.4532121659837;533.6548812875048;34.959842575005446;4.679641476575302;58.002274543060885;24.796825087904608;90.46524195925227;58.94332625777971;HELO_4468;OmpA/MotB domain protein;COG2885;Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins;OmpA;HELO_RS19040;M;;yggW;;HELO_4468;OmpA/MotB domain protein;1.4060118658859908;-0.09148720276509259;-0.019564810065324068;-0.12229430928780083;-1.5283061751737916
HELO_4469;81.46817240385074;67.48580021621383;101.73717245953678;109.07235976761609;102.44426960492773;96.32189703130547;4.599621649940555;2.7842461709478057;6.219425883448819;1.844617605971777;10.778709569861793;4.23526852741322;rlmJ;23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ;COG2961;23S rRNA A2030 N6-methylase RlmJ;RlmJ;HELO_RS19045;J;rlmJ; 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ;2.1.1.266;rlmJ;23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ;0.2680325440332547;0.0781219262162649;0.08801738076604604;-0.2389270060202593;-0.506959550053514
HELO_4470;66.0411831032091;85.03332715834405;62.137824457267016;56.369896363917796;58.970645876439995;64.49664853633136;3.5000080656986303;2.232281318861067;3.9336949177806826;1.9504877298873562;2.4319503188469422;0.9770982973987744;mnmE;tRNA modification GTPase MnmE;COG0486;tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE;MnmE;HELO_RS19050;J;mnmE; tRNA modification GTPase MnmE;3.6.-.-;mnmE;tRNA modification GTPase MnmE;-0.3598480229575074;-0.0529165353276948;-0.12716457529539404;0.03362652326208959;0.393474546219597
HELO_4471;308.4426025181381;632.2945632168781;474.7002113644428;427.4897792660989;493.06042836655706;507.6212080378073;15.699643958239141;21.927181011481885;14.273118826137237;34.70702787750962;28.217470291591138;16.0249581246751;yidC;membrane protein insertase YidC;COG0706;Membrane protein insertase Oxa1/YidC/SpoIIIJ;YidC;HELO_RS19055;M;yidC; membrane protein insertase YidC;;yidC;membrane protein insertase YidC;-1.0332048605007582;-0.09653895318274763;-0.0419041113533094;-0.7169197859683241;0.31628507453243415
HELO_4472;1571.5129015158636;1999.4663590408215;1016.775486278821;1005.5857144632864;946.3697745268532;1097.1017623371656;100.42517695295977;48.7667393882406;78.14709295006797;64.06650790358489;80.70869592240953;39.7374033627162;rnpA;ribonuclease P protein component;COG0594;RNase P protein component;RnpA;HELO_RS19060;J;rnpA; ribonuclease P protein component;3.1.26.5;rnpA;ribonuclease P protein component;-0.34726451413015447;-0.10959240803830106;-0.213012207597556;0.518060096866126;0.8653246109962804
HELO_4473;390.8207037483367;298.77907055533524;369.18548142162416;295.4204136134186;245.999679226779;339.40002098066253;75.74963884724067;154.43877596394336;106.39339154472239;28.687930032148927;63.478431757529655;94.31434348742157;rpmH;50S ribosomal protein L34;COG0230;Ribosomal protein L34;RpmH;HELO_RS19065;J;rpmH; 50S ribosomal protein L34;;rpmH;50S ribosomal protein L34;0.38629396814102535;0.12101718824861507;-0.46272195773098446;0.20296250546846117;-0.18333146267256417
HELO_1458B;1.5225625976497603;0.7371662510279933;8.818075677147078;9.639026095668948;3.637943489755445;5.498089343931103;0.9272997348573221;0.9684100352122804;3.1556716202323507;2.345575663567206;0.43761546706685295;0.8065773854429003;;;;;;;;;;;;;0.5381542403276114;0.595424707159462;-0.4865303379802146;-1.3651255093941228;-1.9032797497217342
HELO_1475;21.959527391821638;7.527561004924167;3.5529387017824923;3.0787254758255376;3.1617410378687474;3.4287472333574107;4.029945850664015;2.856418813497933;1.0253536872738964;1.0690543659507459;1.342121583794565;0.9000571631848822;;;;;;;;;;;;;1.4288878694847025;0.039899376758681715;-0.0897114621594075;2.3741223810986964;0.945234511613994
HELO_1714A;710.7062403181313;2554.865196874258;90.01368136467279;45.699061172744415;41.73252349067538;98.60083316982734;86.526698926751;180.73162272268263;16.997460431656478;6.985792198298838;18.92790865991281;23.634858146800987;;;;;;;;;;;;;-1.8444579558756615;-0.13007438010305705;-1.2208232953760731;2.8370521700022433;4.681510125877905
HELO_1870A;1.2685828448170495;0.326164698080514;3.0865165169711233;4.177920149192842;0.990544095785444;2.445582099444893;0.7740736192959831;0.007545819399658393;1.584156336460029;1.7192392766292683;0.48378745924278616;1.3355869606076087;;;;;;;;;;;;;0.774531388729773;0.2461238320471537;-0.7915849023228715;-0.6029563881556825;-1.3774877768854554
HELO_1870D;22.083883883076407;6.91798448773923;45.04464961123304;66.67953785705036;29.78882089288521;34.35060933969185;1.1334193376035238;0.858863163063384;5.658700722285117;4.807240396124063;13.723036815984019;17.88281956265412;;;;;;;;;;;;;1.5436808329977163;0.3812984418429819;-0.19932846490618683;-0.6148491039617205;-2.158529936959437
HELO_2257;16.863752185843733;7.664087399865859;3.4366885100873055;6.863322861840035;7.200957680965423;3.747614025887922;1.6253251399775317;0.9101794637594177;0.6549976974501253;1.6925472507055703;1.2934977588755847;0.5324241071537917;;;;;;;;;;;;;1.0439154412193883;-0.0977193823972371;0.7885897420281656;1.9117605868327852;0.8678451456133969
HELO_2258;35.70721092747988;11.943816147278447;1.6307815988189134;2.789194215931732;3.3560327248884128;1.5640403585700762;3.9255433623897837;1.2257596469201049;1.2662183043862183;0.44701637846774406;1.43465205560453;0.632657235539631;;;;;;;;;;;;;1.5038004792038144;0.0370725139127821;0.764595821927049;3.8395726247366637;2.3357721455328493
HELO_2306C;72.5800720833541;39.30126024952219;25.94876992523667;45.54329944062453;23.88336926267549;20.652089366375503;2.7919008495518;4.093487910124302;2.8216414146801547;11.3259525259789;5.8811575079876;2.6541066698649187;;;;;;;;;;;;;0.8684901360854722;0.3157131750375255;0.20067559503528898;1.7648088419337906;0.8963187058483184
HELO_2306H;43.37197529312644;14.053613617330361;15.922515309109677;30.955308311909693;22.86391013835616;14.876666069905482;2.318477178108583;2.2712732766146306;1.1181621063805314;3.0372066181315756;1.9479798178715184;1.4344182845492879;;;;;;;;;;;;;1.5595389313323467;0.09203602826658086;0.5879224564476977;1.4827407848307135;-0.07679814650163319
HELO_2482A;86.60050488288111;32.26288510996471;16.858625936694068;19.350924444552202;20.160505254727514;21.930531604011435;10.579883181363254;5.267904260134302;5.604450142802649;4.5277504518605065;0.5002423775442478;1.5546463678951765;;;;;;;;;;;;;1.397025876247409;-0.3606487195448871;-0.11589572619439892;1.933669383128577;0.5366435068811679
HELO_2643;16.02305254212481;80.88047961667586;5.2668356602320285;7.12951860450097;5.237864622456441;6.632394941767973;0.5957888292942655;4.409120614748751;1.1135458138381193;0.4206709336988908;0.19786559935672765;0.6765998192452474;;;;;;;;;;;;;-2.266029791390012;-0.28439866540404024;-0.29108358329346107;1.1572820303108826;3.4233118217008944
HELO_2665B;1.573115612790897;2.99734733409997;1.5093171164950379;1.8267589763131518;2.1645637795371537;0.8057046818056386;1.1636512751936823;0.2971305271370892;0.20541292702650285;0.49062826042092783;0.6425444338424772;0.26897473279039413;;;;;;;;;;;;;-0.6355266553000021;0.47473284056505183;0.8094446813509956;0.5109543171563878;1.14648097245639
HELO_3292;53.21342070165978;32.549302975533;145.36965854201364;0.0;235.86949813830338;131.81800620990043;6.219054850630284;4.801224324919032;21.674885802526305;0.0;20.24762837176629;3.566978039504008;;;;;;;;;;;;;0.6923672463306092;0.1401657766137845;0.8346416867220965;-1.2927288023318866;-1.9850960486624958
HELO_3301A;23.22301774344321;4.299199832813877;7.6843551679283095;0.0;6.373741783608945;6.5885350336829385;3.1018862373660574;0.6790932567953718;2.718175824000285;0.0;0.3553046948238687;1.2690785991240072;;;;;;;;;;;;;2.192532172006593;0.19459732938552854;-0.041424503820757685;1.6744853041268382;-0.5180468678797547
HELO_3420;176.39256744447212;121.10436271953309;62.230789136253996;62.19758501241481;110.21349683709788;92.27638690546208;14.386778464175976;5.188780236833961;3.304338482472235;4.2923205228862;45.112646819952666;29.361716671696644;;;;;;;;;;;;;0.5388308156324211;-0.5608846814836426;0.2537480723102261;0.9273617521332413;0.38853093650082027
HELO_4075;54.67873301052693;37.15343505717171;53.25167365072167;64.51688967561783;41.55780037110606;48.51533297644877;0.5546551537690648;3.1528928109147056;1.2783798531850787;3.043756049890782;3.9437074720312073;5.6138252674288;;;;;;;;;;;;;0.5453134298665558;0.13179230400338948;-0.2184517549352547;0.1692510414931343;-0.37606238837342154
HELO_4091B;4.977997706354718;1.3698958283805271;19.904658114025967;35.30519459590346;28.411714585118357;18.881504295076052;1.6075012403643116;0.8257033288380391;1.5596503560908577;3.7150440431177594;3.3760551050840615;5.020759013194834;;;;;;;;;;;;;1.3348386983583902;0.0723975292434913;0.5649639702928697;-1.733692671130381;-3.0685313694887713
HELO_4166A;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;;;;;;;;;;;;;0.0;0.0;0.0;0.0;0.0
HELO_4401;76.9094665804055;14.658009297792878;111.41993760459552;122.70124952077911;139.82262102976094;96.56527089051453;5.67436931837319;4.377419223419965;7.584482838150339;10.718444890199745;17.08083059681909;20.775376165065175;;;;;;;;;;;;;2.314897831828804;0.2044583134312692;0.5294394939171747;-0.3245690636265284;-2.639466895455332
HELO_1016A;164.86617640199952;227.04477400452961;163.24154318224825;196.53662115671423;164.81377469050986;161.03459913786207;10.494187244714869;11.668943761986018;9.110911494438282;17.185077079990574;9.623502334655138;12.616319717903206;kdkA;3-deoxy-D-manno-octulosonic acid kinase;COG0478;RIO-like serine/threonine protein kinase fused to N-terminal HTH domain;RIO2;HELO_RS00085;T;kdkA; 3-deoxy-D-manno-octulosonic acid kinase;2.7.1.166;kdkA;3-deoxy-D-manno-octulosonic acid kinase;-0.4592973885486522;0.01951718421445303;0.033261957493521344;0.03371781676195251;0.4930152053106047
HELO_1107A;304.5726773202321;214.65086705080353;285.1086723109127;189.15752159135968;293.47101176484983;312.7085299109023;12.646818531985897;11.89498323859789;8.451104898971202;9.154691077796679;16.17775549993767;17.163606470992836;csy4;CRISPR-associated endonuclease Cas6/Csy4;;;;;;;;;csy4;CRISPR-associated endonuclease Cas6/Csy4;0.5028180344243518;-0.1328615291912829;-0.09129913774892451;-0.03790920636120276;-0.5407272407855546
HELO_1308A;65.80495318004448;41.08003925622213;67.56567449565519;92.08077650635853;65.56997364666366;63.464587283572136;5.663245100922115;0.8423807813234336;3.8385603353061;1.4543875159503485;3.4924987697022267;5.701522666005818;HELO_1308A;GAF/sigma-54-interact/HTH domain transcription regulator;COG3604;FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains;FhlA;HELO_RS01605;KT;;;;HELO_1308A;GAF/sigma-54-interact/HTH domain transcription regulator;0.6668190231952158;0.0889796579809774;0.04636474326933193;0.051448219846722765;-0.615370803348493
HELO_1308B;9.929388462655952;4.4208479157522795;21.66748496620245;15.045529929206774;10.680967968461845;9.84451710723282;0.3011082151405491;0.4047284296574273;4.733575281026087;8.907102137726291;5.403268287532072;4.158215371902264;HELO_1308B;uncharacterized protein;;;;;;;;;HELO_1308B;uncharacterized protein;1.0116222422899042;1.0636585150479165;0.10719401815343055;0.011246866419843293;-1.0003753758700609
HELO_1348A;90.49541012505308;75.95518439857116;53.11500904295286;68.05571484834314;57.977535371676616;57.83966242380356;6.659903829992931;7.55906229515372;8.083660842524106;3.6992089668304873;9.452215696963828;1.3612617646393754;HELO_1348A;uncharacterized protein;;;;;;;;;HELO_1348A;uncharacterized protein;0.2496808494549514;-0.12076018199615568;0.0033765649275050436;0.6369104027388213;0.3872295532838699
HELO_1458A;18.881742296211705;15.93856998047263;52.58845245295486;58.326881719440884;26.003171246590654;32.32303605072994;1.636407267312735;1.017123458831336;9.121536209446962;18.408311488621138;8.354604547347273;4.017075239687038;HELO_1458A;probable deaminase (homolog to ribD deaminase domain);COG0117;Riboflavin biosynthesis protein RibD, pyrimidine deaminase domain;RibD1;HELO_RS02410;H;;;;HELO_1458A;probable deaminase (homolog to ribD deaminase domain);0.23113210817627383;0.6854023038156276;-0.303391003137639;-0.7450756600594026;-0.9762077682356765
HELO_1458C;18.271269562024234;7.964963180088399;41.6304144719548;43.13947226421043;32.67449131939048;32.83455454182828;4.268386361676364;0.9928249825626586;3.1961017553266506;3.226701079602265;5.715345340098744;3.2334665649470304;HELO_1458C;uncharacterized protein;;;;;;;;;HELO_1458C;uncharacterized protein;1.104082054386701;0.3333856874238954;-0.006841241703607004;-0.8120457771459098;-1.9161278315326107
HELO_1485A;61.27053563039072;355.4560211781739;309.2498333539099;82.05742283567963;333.6396574204626;314.8298757166692;4.841445764947247;66.8957722218084;70.63054782037639;4.063910380725578;31.178547931448353;109.27282748559303;HELO_1485A;uncharacterized protein;;;;;;;;;HELO_1485A;uncharacterized protein;-2.5171024968939593;-0.025717212995797212;0.08346077774054805;-2.3425260544663837;0.17457644242757553
HELO_1490A;34.035247173215346;9.316871983561235;24.08149650549868;31.920445392086908;26.653737638322117;25.436467992239184;3.177458927416123;0.6587715037863379;1.4064173606700332;3.861073521388815;2.4750477910969866;3.315937960941079;HELO_1490A;gluconolactonase family protein;COG3386;Sugar lactone lactonase YvrE;YvrE;HELO_RS02600;G;;;;HELO_1490A;gluconolactonase family protein;1.7638014542687692;-0.07590601030028843;0.06494504572495963;0.40627763401838024;-1.357523820250389
HELO_1491A;65.01388576717883;48.54060111932373;93.962859016702;131.2241441597125;66.33739758061137;83.84928499465109;7.009275904918227;5.1914218273228805;4.647629311377732;6.274324828356847;12.063090097870422;7.736107944311337;HELO_1491A;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS02610;K;;;;HELO_1491A;LysR family transcription regulator;0.4141581475817455;0.16246086783516844;-0.33349453681702457;-0.362132980811392;-0.7762911283931375
HELO_1621A;9.022840717746;9.722115479624188;14.609943684056807;22.24273163858304;11.702536826118331;12.018030743890002;0.3253779426193573;0.8985371810746394;3.5048965734234314;4.9950348113833405;2.4150241837948827;1.7401264171892958;HELO_1621A;ABC-type transport system ATP-binding/permease protein;COG1132;ABC-type multidrug transport system, ATPase and permease component;MdlB;HELO_RS03275;V;;xseA;;HELO_1621A;ABC-type transport system ATP-binding/permease protein;-0.0972981169663969;0.2619541060505495;-0.03539457978754701;-0.3772197649840021;-0.2799216480176052
HELO_1630A;32.95135055449274;21.082700400707566;35.459373353849244;45.01473965657275;29.393680851428517;32.64001136529899;3.648403808799334;3.3739239898043745;2.4298362006362493;3.063386957451275;7.159074054183148;6.113004694276934;HELO_1630A;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS03325;K;;guaA;;HELO_1630A;PfpI/HTH domain protein (homolog to transcription regulator CdhR);0.6205523607129573;0.11611157223399715;-0.146406788811988;0.013290771726979678;-0.6072615889859776
HELO_1631A;8.194711841669593;6.003382140522348;7.261804870595985;7.889945477050708;7.5334884838984335;5.974991525353931;0.7198096926619556;0.8025109601411787;0.6522432113131589;0.5374510029726376;1.7998151401827767;1.0257025808272857;HELO_1631A;uncharacterized protein;;;;;;;;;HELO_1631A;uncharacterized protein;0.3927525514196759;0.24426552259689727;0.2909441707494018;0.39861289783917675;0.005860346419500839
HELO_1631B;20.930099518543532;10.73581301051602;22.288518295454328;30.058881266841187;25.934890971416987;16.313501614218186;2.4021797790400026;1.710452896299014;4.784155978863634;3.233900922359736;6.904952567091031;3.2517668463687586;HELO_1631B;cupin domain protein;COG3435;Gentisate 1,2-dioxygenase;;HELO_RS03340;Q;;;;HELO_1631B;cupin domain protein;0.9019945694543257;0.42772131686608805;0.6375786895359115;0.34101482313022924;-0.5609797463240964
HELO_1647A;51.05248931343993;19.89745973057438;29.68964951721057;38.329844096687886;36.09921659227712;29.48460052427028;3.496397774024087;1.2524315385748461;2.0494660992142433;3.8674837228071186;3.7039226207807716;4.122860163700252;HELO_1647A;uncharacterized protein;;;;;;;;;HELO_1647A;uncharacterized protein;1.3166395786453498;0.009671529211436436;0.28330808163463583;0.771886518599219;-0.5447530600461308
HELO_1664A;183.55951127630772;45.73313557493586;48.37900377607798;66.36420683734673;50.035113765797256;42.37417862970044;7.036098984506792;0.7977135410753897;7.305286903366869;12.897899606558152;6.251912590634065;0.5582407470390455;HELO_1664A;uncharacterized protein;;;;;;;;;HELO_1664A;uncharacterized protein;1.9815683451471324;0.18706129247771397;0.23465377049791591;2.0891777458399963;0.10760940069286384
HELO_1665A;4.916804760923566;1.5090325896397978;1.3010946173335063;1.1775493073790602;1.0693147653372617;0.6771090458231801;0.40582259465037956;0.2855536322886727;0.36855517724628456;0.2217071219410263;0.41247997579118206;0.26629385368984104;HELO_1665A;uncharacterized protein;;;;;;;;;HELO_1665A;uncharacterized protein;1.2376870807830576;0.456343809946712;0.3031766153856098;1.8188417945620663;0.5811547137790086
HELO_1727A;458.24883335670637;707.489006023256;876.4937178070222;732.4345046671575;796.6018777402381;787.5520319233034;6.808357391663988;31.891962279118466;64.76179728348238;52.53552420406484;44.668525981723874;48.64941207766384;efp;translation elongation factor P;COG0231;Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A);Efp;HELO_RS03885;J;efp; translation elongation factor P;;efp;translation elongation factor P;-0.6254694098788427;0.15418284370598023;0.0164628530394495;-0.7799298967194535;-0.15446048684061076
HELO_1772A;106.46047099598638;57.843733287786655;90.91232925245818;207.70651503031118;81.28191622568481;87.37972582352172;6.289020232682509;4.559178766551117;8.108254342740567;1.4151609418804427;15.284632857324878;8.647063808478931;HELO_1772A;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS04140;K;;phnA;;HELO_1772A;PfpI/HTH domain protein (homolog to transcription regulator CdhR);0.8688453813605204;0.056542944196232625;-0.10314006297840717;0.2820187058540764;-0.586826675506444
HELO_1772B;24.684306564909445;24.09404768167668;36.03987679993927;34.55134126501432;18.395594076466974;28.477951453504;1.4449327259866336;0.9432319347480869;1.4078960722904519;1.4826638248295738;6.521008738094359;2.3535502741931613;HELO_1772B;rhodanese domain protein;COG0607;Rhodanese-related sulfurtransferase;PspE;HELO_RS04145;P;;;;HELO_1772B;rhodanese domain protein;0.033541926853348336;0.3294430310043621;-0.6039073034783016;-0.1987491452285184;-0.23229107208186672
HELO_1772C;27.286420791933484;29.969304990950366;41.97697531544127;50.33350706711968;20.504130943796923;24.842470174778953;2.166897696718724;3.529881462021338;1.7830337228425435;8.951202245584186;7.249236262760198;2.8707161654345823;HELO_1772C;GNAT family acetyltransferase;COG0456;Ribosomal protein S18 acetylase RimI and related acetyltransferases;RimI;HELO_RS04150;J;;;;HELO_1772C;GNAT family acetyltransferase;-0.13072936901510523;0.7338199727637056;-0.2651301497003091;0.13036565971777314;0.2610950287328784
HELO_1805A;98.06220979543876;76.11627038099142;227.29825070893034;204.95647927054202;216.08255349799379;197.23856830969225;7.664601706417912;3.99805485291834;29.711812461732123;33.21687642585274;40.25076289431585;10.806245586478628;HELO_1805A;uncharacterized protein;;;;;;;;;HELO_1805A;uncharacterized protein;0.3612995243877615;0.20368213183154893;0.13100611061909095;-1.0008309645458215;-1.362130488933583
HELO_1809A;141.7411008432846;116.4205642097881;84.96910011333166;73.19842081587318;84.69282440988546;94.0450704928674;13.982104044148928;20.778354782345517;11.56671281710756;7.419476979357233;13.04581777596695;16.94973697731069;HELO_1809A;DUF1315 domain protein;COG3139;Uncharacterized conserved protein YeaC, DUF1315 family;yeaC;HELO_RS04355;S;;;;HELO_1809A;DUF1315 domain protein;0.28171570993190986;-0.14479359863220242;-0.14943739990061022;0.586717095314401;0.3050013853824911
HELO_1870B;299.0336905612597;47.85127294010484;352.7284553041927;517.1884271351536;280.7284699667705;276.25420701109095;29.77346245828507;5.257372608555214;32.66503618936285;53.2870550356306;83.46013071824942;108.51429405102452;HELO_1870B;uncharacterized protein;;;;;;;;;HELO_1870B;uncharacterized protein;2.6186564482117554;0.3514329279767292;0.02309601031838504;0.11391515719920342;-2.504741291012552
HELO_1870C;64.6049184799039;26.448340911119928;121.01213081444472;173.90106406057137;105.19473367307641;101.14977810759531;1.0138658576200348;1.2059676460655078;1.5379184647128348;6.3800654558985705;37.279741973765944;40.693125772701286;HELO_1870C;probable S-adenosylmethionine-dependent methyltransferase;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS04700;H;;;;HELO_1870C;probable S-adenosylmethionine-dependent methyltransferase;1.2570850299509848;0.2563385218012417;0.056026152686881936;-0.6388101856160748;-1.8958952155670596
HELO_1870E;166.59442820097445;67.41788604731714;343.17575330007867;472.98962913555465;200.16568251282567;267.7798064266845;14.445554991009939;6.00539714973104;19.709832337568276;14.187228322030666;70.11581297660481;134.32705453424126;HELO_1870E;uncharacterized protein;;;;;;;;;HELO_1870E;uncharacterized protein;1.292528752381381;0.35672071338872513;-0.4180405394794384;-0.6814505653381797;-1.9739793177195608
HELO_1983A;172.18231894275925;102.96744194595902;57.94218364915478;71.48054940482407;66.25897490634017;66.78761555023968;5.2060237443657265;3.3705255504705596;6.6283904019027755;0.7279233143285821;3.3185583257802467;8.834662542930813;HELO_1983A;protein-tyrosine phosphatase domain protein;COG0394;Protein-tyrosine-phosphatase;Wzb;HELO_RS05305;T;;kdsB;3.1.3.48;HELO_1983A;protein-tyrosine phosphatase domain protein;0.7361598354371806;-0.20172121503163876;-0.011294933524254702;1.3531980160010315;0.617038180563851
HELO_2105A;1566.1841106821103;980.398911062479;726.2916281100937;786.7257698020252;740.820859469425;619.9731521730808;16.682919272172125;37.20770704835102;46.7881420866111;85.24867903046321;6.801912870382481;54.20853774279782;HELO_2105A;zeta toxin family protein;;;;;;;;;HELO_2105A;zeta toxin family protein;0.6752630999017022;0.22800307470971326;0.25653994120737167;1.335571875776079;0.6603087758743769
HELO_2105B;3266.167299827897;1195.9107686910793;329.2462907538402;365.947280785513;420.4965137789803;390.12304571391115;692.5054436353753;256.9277090447204;146.84381322621041;76.96658825287963;216.65733996827464;99.44880791315536;HELO_2105B;uncharacterized protein;;;;;;;;;HELO_2105B;uncharacterized protein;1.4487247304326072;-0.24408018734899883;0.10789815369442302;3.06234588184145;1.613621151408843
HELO_2105C;261.52878225034164;186.678529234914;442.82649088746007;378.1585062036195;404.4762266279842;408.3491335194358;32.94847526509544;20.143332363149497;51.95430711327977;45.37065875667884;32.61738005156869;7.408052278720241;HELO_2105C;uncharacterized protein;;;;;;;;;HELO_2105C;uncharacterized protein;0.48421198813888644;0.11666393940075892;-0.013714510902733679;-0.6408562407329885;-1.125068228871875
HELO_2105D;2.1003888597976466;1.0828065951243586;2.8201386364207086;1.7571629987970985;3.1670146961755328;2.5830422466699012;0.5708467098874909;0.327854192425776;0.8921047421875377;0.40219912237703903;1.3310255396010786;0.7699841579275519;HELO_2105D;uncharacterized protein;;;;;;;;;HELO_2105D;uncharacterized protein;0.5739202937758006;0.09243994189867477;0.217829134057264;-0.20873588021069311;-0.7826561739864937
HELO_2105E;0.5116321117002851;0.6863769556321923;0.4915503666915389;0.21418327610477453;1.1607639095408875;0.09920237869880323;0.45859865284481904;0.504404664424416;0.5592509080899987;0.18555915534179424;0.48339390942154886;0.17182356013801575;HELO_2105E;uncharacterized protein;;;;;;;;;HELO_2105E;uncharacterized protein;-0.15781998647028228;0.4403556641432437;0.975084417049869;0.4596500400048772;0.6174700264751595
HELO_2106A;1.2867912044999237;1.4084998791775678;0.3178674732104465;0.20233342999561535;1.2700222539605204;0.5267470630246723;0.20260588526929638;0.5233241988936096;0.2794704172754502;0.004906935652454966;0.28868082327970546;0.23962341745593588;HELO_2106A;uncharacterized protein;;;;;;;;;HELO_2106A;uncharacterized protein;-0.07481020507836322;-0.21225577190029793;0.5722453710197202;0.582863576575871;0.6576737816542342
HELO_2151A;58.48958273311772;9.836145903572044;21.428170714189132;30.83985512093614;56.48157541860706;17.813574140089838;10.106776999833976;1.5053446778663588;2.1876213786130334;4.267058825161795;46.02606038601977;8.385012963735047;HELO_2151A;homolog to spore coat protein U;COG5430;Fimbrial subunit ScuA/B, ScuA/B/SCPU domain;SCPU;HELO_RS06295;W;;;;HELO_2151A;homolog to spore coat protein U;2.4567853351031332;0.25353800287888717;1.6113256495163935;1.6608631057993533;-0.79592222930378
HELO_2151B;12.544889255241761;4.46485134769554;2.0897801805004828;3.4983325370210747;2.9247359743182435;1.7047052075529903;3.1948824745482467;1.1687551128839078;0.9804389839802126;0.8632684397969248;2.1333044042843947;0.8015428011542497;HELO_2151B;homolog to spore coat protein U;COG5430;Fimbrial subunit ScuA/B, ScuA/B/SCPU domain;SCPU;HELO_RS06300;W;;;;HELO_2151B;homolog to spore coat protein U;1.3094944398931134;0.19203284284774402;0.5371242442242876;2.3242053330615837;1.0147108931684703
HELO_2151C;29.609667765602524;16.39629775260393;4.181607645227298;4.745119537452108;5.053861468393831;2.5923214246990813;4.410994329771037;4.266589427362209;1.802170610208816;3.6363452216594174;2.2084256156472626;0.2450725798228338;HELO_2151C;homolog to spore coat protein U;COG5430;Fimbrial subunit ScuA/B, ScuA/B/SCPU domain;SCPU;HELO_RS06305;W;;;;HELO_2151C;homolog to spore coat protein U;0.8152070789834394;0.5284833361351138;0.7529392203999385;3.090999039271841;2.2757919602884016
HELO_2151D;50.03280132211861;31.62602781190775;24.080487720750217;33.49781128912105;27.862165325585874;14.53797018941471;4.168108113798903;1.058892736741734;3.29682568361619;8.293319416800376;6.240754228189642;2.8534968002061323;HELO_2151D;probable usher pathway chaperone;COG3121;P pilus assembly protein, chaperone PapD;FimC;HELO_RS06310;W;;;;HELO_2151D;probable usher pathway chaperone;0.6454014857869712;0.6907673545225177;0.8933814903079687;1.7156267882894372;1.070225302502466
HELO_2151E;29.587243319196165;17.96026519646006;14.771447093644104;20.03107821019852;14.631798843319794;12.794121007185543;0.7912561688191595;1.3908328103547676;1.4163768513858659;1.4325172803289443;1.8746159886515334;0.7680401346793913;HELO_2151E;outer membrane usher protein;COG3188;Outer membrane usher protein FimD/PapC;FimD;HELO_RS06315;NW;;;;HELO_2151E;outer membrane usher protein;0.6899509463106828;0.19326151146319548;0.18043027951535917;1.1488765617994239;0.4589256154887411
HELO_2151F;38.27975930925573;24.13278260817134;27.57289854310932;28.73287806863632;29.935907349035812;22.721894216198677;0.7200769549454219;2.3764740212118327;4.209948232506747;7.2260490161879805;7.378871187327049;1.7774116407648244;HELO_2151F;homolog to spore coat protein U;COG5430;Fimbrial subunit ScuA/B, ScuA/B/SCPU domain;SCPU;HELO_RS06320;W;;;;HELO_2151F;homolog to spore coat protein U;0.6442156795299825;0.2684281810722142;0.38306313368700895;0.7275668743401171;0.08335119481013464
HELO_2165A;26.85171269816304;5.883774487639432;30.389512538058955;127.62664070835496;103.15882679320457;20.556275942942637;2.2870762130574764;1.1872045470859394;4.759755656323188;11.716389623927558;44.474735375833596;9.067865604609059;HELO_2165A;UspA domain protein;COG0589;Nucleotide-binding universal stress protein,  UspA family;UspA;HELO_RS06400;T;;;;HELO_2165A;UspA domain protein;2.016494306007461;0.5421746648617312;2.272605238639356;0.3696580866337458;-1.6468362193737152
HELO_2165B;18.986811816902236;13.293867637586343;94.09232900485165;72.97189400071817;40.521780034190236;42.56759663190726;2.174826268288377;2.5512892418549;31.14092650760799;16.48219766086012;23.456454879660985;29.972523755538745;HELO_2165B;uncharacterized protein;;;;;;;;;HELO_2165B;uncharacterized protein;0.4836520259170487;1.1260734346869974;-0.06938723724604667;-1.1242071705592194;-1.607859196476268
HELO_2306A;127.73354611090453;50.19768581278669;61.369582925899486;59.967474662374265;46.79445656696342;48.97514505121952;9.59321329713492;6.251329354727525;12.238240112216934;15.359832746401691;6.675251608469283;5.498062883635736;HELO_2306A;DUF2743 family protein;;;;;;;;;HELO_2306A;DUF2743 family protein;1.3302375425958184;0.31963185709570574;-0.06436745721459758;1.36510538866791;0.0348678460720917
HELO_2306B;160.02537135842644;83.8902975584134;69.35859833814008;92.55402916614622;67.01952243589808;66.36144106931238;14.586770188227698;11.392999042919312;10.966106197110639;25.405018600406887;7.837636137225552;6.202409247061439;HELO_2306B;DUF4145 domain protein;;;;;;;;;HELO_2306B;DUF4145 domain protein;0.9236164419827375;0.06280373974141096;0.014025874501862212;1.2572931115296715;0.333676669546934
HELO_2306D;39.169306470527324;18.950516642673332;33.25434711671957;64.74532640661572;51.23841811828155;30.916368671253;2.493480585549156;0.1241377865116335;2.8030831091326007;3.344289056192173;4.528828191630888;7.1725189049123745;HELO_2306D;uncharacterized protein;;;;;;;;;HELO_2306D;uncharacterized protein;1.0096674459805568;0.1019905715187841;0.7108146936267259;0.3317970369540735;-0.6778704090264833
HELO_2306E;26.836355888687876;12.47876859560067;12.416874553864952;27.17929853435591;15.973241978038496;8.972770392395;1.1707339224740503;1.0146771562153794;2.9968292306140647;9.017209765289504;5.270906140928496;2.057186149030003;HELO_2306E;uncharacterized protein;;;;;;;;;HELO_2306E;uncharacterized protein;1.0462816579204484;0.4279823966137668;0.7671959136601321;1.4809041177002755;0.43462245977982716
HELO_2306F;45.817522437141655;13.076177898144932;16.16891859562804;37.43960880805303;27.59552053013;17.979184508868396;2.7416961456139717;0.9975614166230642;3.169351956436874;0.7333357507449623;6.437673513601282;2.952791062184623;HELO_2306F;uncharacterized protein;;;;;;;;;HELO_2306F;uncharacterized protein;1.7337929372332157;-0.14461883209084014;0.5913711629922735;1.3026305852160123;-0.43116235201720343
HELO_2306G;38.88363314553393;13.609492516018578;19.490000852003288;38.01726520578601;25.40261939469833;19.723708778179816;2.8681289782116552;0.09428226965653944;0.2760404935237077;5.875878549177274;0.6974931627023879;2.276696259893109;HELO_2306G;uncharacterized protein;;;;;;;;;HELO_2306G;uncharacterized protein;1.4488907713699675;-0.01636217090010028;0.34939885071937393;0.9445146208341209;-0.5043761505358466
HELO_2306I;43.22869265403707;11.042190663774159;25.94595808581485;33.09418188862352;30.278609393436124;16.49349422426759;3.5710389711723587;0.8568399757743782;2.3025068440306216;10.91666436898568;5.815245641701832;3.071412302713975;HELO_2306I;spectinomycin adenyltransferase;;;;;;;;;HELO_2306I;spectinomycin adenyltransferase;1.8768847336909786;0.6232503958227635;0.8383578856817113;1.3381641105374351;-0.5387206231535435
HELO_2306J;104.29462571619928;38.31566895983714;114.22909905438202;124.12672525433199;114.59641143577365;83.27216389988921;3.5911483409302307;2.6297446461190535;17.400746509439788;35.00035455047374;24.316326921765977;9.478174817906424;HELO_2306J;GNAT family acetyltransferase;COG1670;Protein N-acetyltransferase, RimJ/RimL family;RimL;HELO_RS07165;JO;;;2.3.1.267;HELO_2306J;GNAT family acetyltransferase;1.4212554951542309;0.4513770140991964;0.455968536043712;0.32130372685656994;-1.099951768297661
HELO_2306K;106.48774560296455;63.05211564761252;25.608136663062925;23.075674707850766;15.852802741339772;14.685276424151965;6.533878414875294;6.092506228263261;4.824748968170436;11.718668093179165;1.209162459902156;2.201913088077779;HELO_2306K;cytidine deaminase domain protein;COG0295;Cytidine deaminase;Cdd;HELO_RS07170;F;;;3.5.4.5;HELO_2306K;cytidine deaminase domain protein;0.7468540624735471;0.7624565293851795;0.10357758758672642;2.7766893319325003;2.029835269458953
HELO_2397A;452.5861697690121;198.83302187355807;513.6840495750806;594.029077725888;350.74999907734673;409.92554181351016;33.62073609848585;23.802740986390045;69.70932196042885;21.352401600044416;108.72345223894504;94.80198244201854;HELO_2397A;probable aminotransferase;COG0399;dTDP-4-amino-4,6-dideoxygalactose transaminase;WecE;HELO_RS07650;M;;rmlA;;HELO_2397A;probable aminotransferase;1.1825816476073303;0.32481006650292343;-0.2243265869108786;0.1424996453542935;-1.0400820022530368
HELO_2397B;310.63618796446855;159.2458254155159;310.11793299579244;448.66676488754985;228.10425977111507;284.6136092030608;40.960803894445;36.10820627669636;43.39220732765136;43.95583462026691;71.58500622111296;47.645625158372155;HELO_2397B;WbqC family protein;;;;;;;;;HELO_2397B;WbqC family protein;0.9595759989409771;0.12339683096263698;-0.31806044083670404;0.12579804845976383;-0.8337779504812133
HELO_2397C;350.2202780415664;223.80552525111173;395.730700443193;527.2591364485457;279.2356028187517;319.8005068626643;29.619003708272086;46.13383103568471;65.90748512820582;39.6118903554813;88.01402350045774;61.795421960148204;HELO_2397C;uncharacterized protein;;;;;;;;;HELO_2397C;uncharacterized protein;0.6436986482370406;0.3064836214716422;-0.19503616516353794;0.13069972142466213;-0.5129989268123785
HELO_2397D;331.9915942743339;279.2368065856005;365.53747974765037;482.1436590565225;230.74679384666032;264.76539748608394;39.06089607535922;64.21950107903042;94.63312715114563;53.65303048664108;77.71131979871268;42.76492276254593;HELO_2397D;uncharacterized protein;;;;;;;;;HELO_2397D;uncharacterized protein;0.24883930648441854;0.4638074478371603;-0.1976038990128215;0.32533248101214873;0.07649317452773019
HELO_2397E;284.71671493612695;267.35790150290995;326.70072719924354;375.7674512470041;188.6315673652069;248.18894404167852;23.832945275878053;50.69284293688913;66.19401794007995;25.598889405622415;66.87996441985938;49.60418511965307;HELO_2397E;sulfotransferase domain protein;;;;;;;;;HELO_2397E;sulfotransferase domain protein;0.09042707166645059;0.39513881374563553;-0.3940409155240783;0.19734537835286048;0.10691830668640989
HELO_2397F;528.1853226831221;489.55899418094646;574.8316260623579;449.31742372408866;370.390590196253;405.92349380691184;50.06066798162464;108.62172752293651;131.38111564612936;54.21024140338298;126.85780693193992;83.34677486251653;HELO_2397F;uncharacterized protein;;;;;;;;;HELO_2397F;uncharacterized protein;0.10934640395934458;0.5008894502756718;-0.13182031445760067;0.3790154709432727;0.2696690669839281
HELO_2397G;510.5003187124428;447.4316107648019;754.2523980593095;649.5411313950567;513.4539668435797;649.7309158638535;45.017538341680584;90.15607732401408;98.00818683814835;86.90829222692994;119.25601668665517;67.71326750970071;HELO_2397G;uncharacterized protein;;;;;;;;;HELO_2397G;uncharacterized protein;0.18984715896326598;0.21489776277270067;-0.3390191059388208;-0.34732595809393985;-0.5371731170572058
HELO_2397H;584.3503035349603;426.40049730242555;927.1762079159745;684.8731631199358;593.2142801120381;687.2098326899448;43.923690205452274;48.81920898968616;101.9255642416336;20.29437165416353;199.61655874639715;156.28663727127818;HELO_2397H;uncharacterized protein;;;;;;;;;HELO_2397H;uncharacterized protein;0.4537116789357114;0.4315502126563082;-0.2118652281744673;-0.2335482389168817;-0.6872599178525931
HELO_2397I;446.4159457965443;308.71745508599344;956.6104784264471;652.2549053034189;666.9110788803338;752.1160321497199;33.532152429474785;29.3698649862053;67.52516144378204;23.0389724644009;216.57768768848155;172.28753912164512;HELO_2397I;probable glycosyltransferase%2C type 14;;;;;;;;;HELO_2397I;probable glycosyltransferase%2C type 14;0.5306639817679724;0.346566781508459;-0.17321611229045608;-0.7512554825919313;-1.2819194643599037
HELO_2403A;21.611852959679155;12.60053029657198;112.43352907255193;116.79249895625149;98.13030444616543;65.14690573817286;6.720228576594547;6.238010668961959;22.549626975159335;23.42106768944669;29.002790796210974;19.165805635330607;HELO_2403A;uncharacterized protein;;;;;;;;;HELO_2403A;uncharacterized protein;0.7334163160676948;0.7781015641839355;0.5836524904741687;-1.5485944501990536;-2.2820107662667484
HELO_2403B;75.44989494385415;72.95601154976704;185.07616064327286;265.2250257630284;235.3735730630374;188.52794350184686;5.9192884180696295;2.15942606237296;17.453483212258813;13.98059669579788;13.591196735712375;28.454699624353104;HELO_2403B;uncharacterized protein;;;;;;;;;HELO_2403B;uncharacterized protein;0.04784709681332089;-0.026517336506021394;0.3186581777150108;-1.3098241470702598;-1.3576712438835807
HELO_2406A;3.0784203937441372;5.1989075836863945;5.181639456682986;5.125902889320762;6.67401855386264;6.237428982233872;0.36105889049251016;0.19597939912188667;0.22299889205683374;0.13808467366757718;0.318938491396894;1.0663839261235035;HELO_2406A;BCC family transport protein;COG1292;Choline-glycine betaine transporter;BetT;HELO_RS07735;M;;;;HELO_2406A;BCC family transport protein;-0.6040035032011364;-0.22748777497835615;0.08450496639394256;-0.8274667940808285;-0.22346329087969208
HELO_2407A;197.73782887795582;150.65411808172257;299.7336580735342;345.5648493505119;299.47843342247955;308.70828487433704;8.223893465756491;11.988654760384975;7.5474818002856985;12.0485647971019;33.05006501287405;39.23490377837005;wcbR;polyketide synthase WcbR;COG3321;Acyl transferase domain in polyketide synthase (PKS) enzymes;PksD;HELO_RS07745;Q;wcbR; polyketide synthase WcbR;2.3.1.292;wcbR;polyketide synthase WcbR;0.3900818353669173;-0.04242363325154841;-0.04364852997507285;-0.64004346702096;-1.0301253023878774
HELO_2482B;45.71933226420848;21.79556392885475;20.775365122432138;24.23651119643455;26.69641665789753;17.80287852527195;5.215116001783181;5.569263247701712;2.744942856001995;1.841884745407752;7.171921611677509;3.771140332394247;HELO_2482B;uncharacterized protein;;;;;;;;;HELO_2482B;uncharacterized protein;1.0352665548487652;0.21174336925453474;0.5587457930939266;1.3130661142282287;0.27779955937946355
HELO_2482C;42.488870445404224;57.11126550580934;59.69977914540309;22.888206133380013;63.3523951346815;57.469208291399525;3.531114161707827;11.624899347194242;5.757272970242508;1.3039831966174167;8.791067783428867;4.2577017408495985;HELO_2482C;YrhK domain protein;;;;;;;;;HELO_2482C;YrhK domain protein;-0.4181716354231808;0.05401421079950808;0.13831678869478203;-0.4270308189141714;-0.008859183490990574
HELO_2482D;23.79185607200259;52.36874890981494;46.44421384069566;43.82834073669943;41.154886369004515;39.40766268088213;1.3414062560100168;5.576803408557965;6.60821640541566;4.09202046459123;8.093866969383008;8.59027575076746;ydeP;probable molybdopterin-dependent oxidoreductase YdeP;COG0243;Anaerobic selenocysteine-containing dehydrogenase;BisC;HELO_RS08135;C;ydeP; probable molybdopterin-dependent oxidoreductase YdeP;;ydeP;probable molybdopterin-dependent oxidoreductase YdeP;-1.1061289069651936;0.23160324759529338;0.06107096689617819;-0.7047626188980578;0.4013662880671358
HELO_2632A;9.778122379034494;50.4679305143298;5.894459659220526;25.893732178675943;5.912914086535086;3.978287450469216;1.247975079851108;14.237950225089321;0.9509313970783566;11.05826299014969;1.4945606906582802;0.3211527432857303;HELO_2632A;uncharacterized protein;;;;;;;;;HELO_2632A;uncharacterized protein;-2.2555679011997634;0.46978795242200944;0.47364446085195544;1.1143844326078907;3.369952333807654
HELO_2632B;4.905936136412914;4.089436263543125;1.0846143693822492;2.3372802209933603;0.6641782325285864;1.1420094479245402;0.4042050046918057;0.389501470763016;0.4187046981232887;1.6324675160309485;0.2575982897984861;0.14135389757900413;HELO_2632B;uncharacterized protein;;;;;;;;;HELO_2632B;uncharacterized protein;0.2146598924321439;-0.039184317792166246;-0.3641548899471181;1.4632009125279528;1.248541020095809
HELO_2632C;14.021203062602337;11.917816425918508;6.94392617536714;14.419231571167304;8.774463253427916;8.809105062599171;1.3780730561126295;1.6779379262114833;3.1211983306306945;2.0565047123665723;2.2205808639309477;2.347223442277058;HELO_2632C;uncharacterized protein;;;;;;;;;HELO_2632C;uncharacterized protein;0.2176381408551924;-0.30426930197231794;-0.005104035957126385;0.6148069415782276;0.3971688007230352
HELO_2643A;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;0.0;HELO_2643A;homolog to phage Thibault protein Gp148/Gp103;;;;;;;;;HELO_2643A;homolog to phage Thibault protein Gp148/Gp103;0.0;0.0;0.0;0.0;0.0
HELO_2656A;2.004970065832349;18.5115845729655;1.6235764035954723;1.2084937288995488;1.2624609443369552;2.401473564081592;0.1870037162619802;1.6443049249487018;0.4725672448346203;0.7195389282727512;0.7906784901991251;1.3138719540586592;HELO_2656A;uncharacterized protein;;;;;;;;;HELO_2656A;uncharacterized protein;-2.698908422080292;-0.3746250720198825;-0.5882669887376213;-0.17880925714390639;2.5200991649363855
HELO_2656B;1.6971412761178748;12.220442371464722;2.5897127894379537;1.0215174867177408;0.7376506443804751;1.6955168482625755;0.5036159236802722;3.670991004694332;0.3799180368439802;1.361541032203776;0.6280595398070027;0.20122827196472126;HELO_2656B;HTH/peptidase S24 domain protein;COG4197;DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily;YdaS;HELO_RS09140;K;;;;HELO_2656B;HTH/peptidase S24 domain protein;-2.29326745496121;0.4133064924558323;-0.6334238704541878;0.00086916471541576;2.294136619676626
HELO_2656C;373.56945032265133;186.65781977171142;350.925791565555;346.65132580677954;318.7726883492092;384.66709519166074;17.115627690972953;14.699739375140227;17.23547947492888;23.523322565687007;15.697518163865029;33.22148499860065;HELO_2656C;HTH/peptidase S24 domain protein;COG1974;SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase);LexA;HELO_RS09145;KT;;;;HELO_2656C;HTH/peptidase S24 domain protein;0.9971288298481111;-0.13208481295757046;-0.2703093375259371;-0.042122822660548564;-1.0392516525086597
HELO_2656D;0.4415548698649192;5.680876597428509;1.2598755605516294;0.35414231121062884;0.25711091716030116;1.1408993327517678;0.09298491935216265;0.551164831499136;0.6836044796455437;0.4077294784662933;0.2567118623724835;0.8678909217987483;HELO_2656D;homolog to phage YuA protein gp49;;;;;;;;;HELO_2656D;homolog to phage YuA protein gp49;-2.212411659910154;0.0780263728670254;-0.7681050133846705;-0.5705912091996367;1.6418204507105172
HELO_2665A;7.392428651324537;2.53531507408989;1.253491229464115;3.0381019633657345;3.5652095686134135;1.2358869362747926;2.4741486476775867;0.7259101768320966;0.42528117344162697;0.620111461659984;2.2570478371766933;0.2884798775576635;HELO_2665A;uncharacterized protein;;;;;;;;;HELO_2665A;uncharacterized protein;1.2472495703011197;0.011314598914986984;1.0298338532753102;1.9082411306134788;0.6609915603123591
HELO_2767A;2.217527582823173;4.985047004281475;6.387939725649399;6.687756007112238;10.021370755015454;6.342999114166439;0.45846105741867565;0.8322182303269315;0.8666258396745785;0.4899825213753099;0.4913962536475958;1.2517833473302087;HELO_2767A;ABC-type transport system permease protein;COG4160;ABC-type arginine/histidine transport system, permease component;ArtM;HELO_RS09725;E;;;;HELO_2767A;ABC-type transport system permease protein;-0.8954100613341851;0.0088026702401236;0.5858623355585402;-1.1904169096742472;-0.2950068483400621
HELO_2775A;1.2630799649876014;3.8272452924473908;0.38502863727276493;0.7270225536439443;1.2330613086948645;0.7113723362699287;0.11620056431895805;1.6318162445508497;0.3426303618871669;0.5359329897516169;0.6336352311735105;0.15971853741524736;gspI1;general secretion pathway protein GspI;;;;;;;;;gspI1;general secretion pathway protein GspI;-1.0929125754579874;-0.3052378690447126;0.3838691856659008;0.40313388730518807;1.4960464627631755
HELO_2779A;0.9166558661438171;3.907061365621517;1.5947764710560994;0.30433531207939346;2.426731823792688;1.2625908314851717;0.31645327490437153;0.31703032602354614;0.707717781868116;0.1256065448058628;0.6661913508811864;0.5725783574037783;HELO_2779A;uncharacterized protein;;;;;;;;;HELO_2779A;uncharacterized protein;-1.3562679876028063;0.1976345516933975;0.5988575806792136;-0.2393843845616781;1.1168836030411282
HELO_2823A;5.719140836789426;5.524481756851888;4.331015689624283;5.021287070183685;5.623383102001216;3.9021848071308214;1.5142063516600686;0.929540432411459;0.629820733427822;0.8785830964470459;1.777490954882226;1.4594956081652668;HELO_2823A;uncharacterized protein;;;;;;;;;HELO_2823A;uncharacterized protein;0.04241345806545871;0.12098555477400685;0.4341434340366632;0.4548518969521589;0.4124384388867002
HELO_2823B;1.319322654846039;1.451722767711815;1.0160796093839795;0.46448414207323657;0.7564698427887655;1.4163601875643277;0.25794241499285103;0.2966336489595724;0.38968164695936436;0.41392214357286544;0.3751784218054988;0.4527199323439898;HELO_2823B;PfpI/HTH domain protein (homolog to transcription regulator CdhR);COG4977;Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain;GlxA;HELO_RS10070;K;;;;HELO_2823B;PfpI/HTH domain protein (homolog to transcription regulator CdhR);-0.08009231742974987;-0.26128291376713464;-0.46015671492049703;-0.05913198586841428;0.020960331561335588
HELO_2845A;19.330846461587598;8.036004503329076;16.585697913177626;17.971740945660574;16.326224636911302;16.526595552646434;1.876830249560191;1.3355255268222832;1.8314983227927053;1.782538813959102;1.226140255277121;1.8478832651216457;entD;4'-phosphopantetheinyltransferase EntD;COG2977;4'-phosphopantetheinyl transferase EntD (siderophore biosynthesis);EntD;HELO_RS10195;Q;entD; 4'-phosphopantetheinyltransferase EntD;;entD;4'-phosphopantetheinyltransferase EntD;1.1699133872554737;0.004856803959830458;-0.016588460259765014;0.21412449458090332;-0.9557888926745703
HELO_2941A;31.86579636955841;48.97407533536779;39.81441130287457;64.28226273570557;94.1999311109027;53.905106704462064;4.313801279700576;12.966968197754838;7.665069745173594;1.2588170037543696;1.5066859295246615;32.90169185550829;HELO_2941A;uncharacterized protein;;;;;;;;;HELO_2941A;uncharacterized protein;-0.6045929298464241;-0.4278616916471103;0.7940201895385544;-0.7403533966759532;-0.13576046682952914
HELO_2941B;63.21734616492339;101.50734338731667;89.50024168482396;146.73937134145726;197.87382254578816;119.02533395414734;3.43916910134214;8.10135190089789;5.548626191585071;7.976166536740716;19.001156113131778;64.93969110553464;HELO_2941B;uncharacterized protein;;;;;;;;;HELO_2941B;uncharacterized protein;-0.6746923139057426;-0.4073454000112271;0.7285144388432858;-0.9023039992651514;-0.2276116853594088
HELO_2941C;69.9994163719406;116.78350622798058;88.7726640082946;130.7771833643525;148.05690095854732;92.8274275586352;8.802046044163767;11.741160105032833;14.251666396392952;33.11935761076129;14.869421337994602;51.52449015941601;HELO_2941C;uncharacterized protein;;;;;;;;;HELO_2941C;uncharacterized protein;-0.7302584554537663;-0.06373350411947243;0.6677815530506379;-0.402202546401929;0.32805590905183735
HELO_2941D;54.66429434874319;136.9229439755138;47.052416544392905;51.95970160665644;77.14027833060078;68.81199692117916;1.1133071313866099;17.261580060966384;2.4048621110741375;5.662517080092566;10.330022194264147;40.867806900565654;HELO_2941D;GNAT family acetyltransferase;COG1246;N-acetylglutamate synthase or related acetyltransferase, GNAT family;ArgA;HELO_RS10720;E;;;2.3.1.-;HELO_2941D;GNAT family acetyltransferase;-1.3090383562316514;-0.538865993684797;0.1625914150243597;-0.32672276633535446;0.982315589896297
HELO_2941E;67.05804642555431;173.1638402269438;84.02487121989425;101.3383027065827;149.14257135686105;134.67464498509705;3.9260864513768268;12.002235674378188;2.7706668496967537;7.943867445849353;24.964307629728463;70.33925723835142;HELO_2941E;spectinomycin adenyltransferase;COG1708;Predicted nucleotidyltransferase, MJ0604 family;MJ0604;HELO_RS10725;R;;;;HELO_2941E;spectinomycin adenyltransferase;-1.3556074785825825;-0.674194312720533;0.14618196242460257;-0.9953134885153103;0.36029399006727214
HELO_2941F;54.19375718461285;162.2046475064141;88.09853356242331;105.17048990751748;151.5030240095642;130.69852258894784;4.6973043602604605;21.2244952680979;8.348114003300411;7.821090456535112;17.97605940643509;83.58290054726585;HELO_2941F;uncharacterized protein;;;;;;;;;HELO_2941F;uncharacterized protein;-1.5641051388403815;-0.5637655690384138;0.21159868906977675;-1.2546621593044671;0.3094429795359144
HELO_2941G;51.96891371146171;167.0557540400027;100.37508847879486;141.28839918612945;199.63046058719365;163.27944317530896;1.894591273209762;38.445686509292365;19.952750155133167;7.757839330749788;16.49767696914583;126.9020615007519;HELO_2941G;DUF3800 family protein;;;;;;;;;HELO_2941G;DUF3800 family protein;-1.6657221125417205;-0.6964487888196249;0.28838869637391884;-1.6329341352218592;0.03278797731986138
HELO_2941H;40.716125183792606;88.34687250653941;73.23742000217847;88.78532688284811;107.97979787747416;97.5472863606496;4.146240906525138;9.005200768683226;5.491213022207907;14.552088694573797;25.864524858385256;61.787763249032956;HELO_2941H;DUF867 family protein;COG4195;Phage-related replication protein YjqB, UPF0714/DUF867 family;YjqB;HELO_RS10740;X;;;;HELO_2941H;DUF867 family protein;-1.0988120712548888;-0.4086695722861542;0.14517267002010037;-1.2402109862902604;-0.1413989150353716
HELO_2941I;84.27620933014053;196.18453983679174;92.94844830785786;115.43466765692123;179.15176949843422;148.31025363781245;3.694833163902236;29.951149736631866;11.17238906104077;9.462601778634271;70.04481721111216;98.30884081270338;HELO_2941I;uncharacterized protein;;;;;;;;;HELO_2941I;uncharacterized protein;-1.2093312278762598;-0.668372004804402;0.27089957876720927;-0.8080980291680868;0.401233198708173
HELO_2944A;104.11328584266921;35.36359591457344;67.39463652404929;66.54425790941293;73.21993527829625;56.07446562168778;3.4075150123096707;4.275946403296897;5.131386624322212;5.241814552057312;7.3730048611516406;7.6017259509159585;HELO_2944A;carbon-nitrogen hydrolase domain protein;COG0388;Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate;Nit2;HELO_RS10760;C;;;;HELO_2944A;carbon-nitrogen hydrolase domain protein;1.5313782543550074;0.2610377472551244;0.37896129615855934;0.8810276790134335;-0.6503505753415739
HELO_2944B;51.68729421119232;10.430113192990888;32.75284225112964;53.48622428734728;36.29176213571828;30.877597981425396;2.5184489834062362;0.8160413029568572;4.09166338060356;3.6387527353863742;6.607877903440395;11.39772673104932;HELO_2944B;LysR family transcription regulator;COG0583;DNA-binding transcriptional regulator, LysR family;LysR;HELO_RS10765;K;;;;HELO_2944B;LysR family transcription regulator;2.204615400406153;0.08246606892051744;0.22631404545861233;0.7249121666401459;-1.4797032337660072
HELO_2944C;21.073854271042066;8.641103453835528;21.964832245325056;27.319116059856498;18.84181429639464;16.760800209862353;0.8310455471099426;0.6638644626996658;4.025453723154242;2.7188647107512396;5.179707205540694;5.629928181815259;HELO_2944C;major facilitator superfamily transport protein;COG2271;Sugar phosphate permease;UhpC;HELO_RS10770;G;;;;HELO_2944C;major facilitator superfamily transport protein;1.1950683757887486;0.3707296613907589;0.15984736541307143;0.31364197414076234;-0.8814264016479862
HELO_2962A;6.907636166728732;4.264904048714783;20.397286039298248;11.616168658439442;18.58364571982272;17.434564741007083;1.0548260093617183;1.2749640872171129;1.756973610852566;1.449312104432529;3.9125343579619236;4.889011030323651;HELO_2962A;uncharacterized protein;;;;;;;;;HELO_2962A;uncharacterized protein;0.5868392548510739;0.21501446825898363;0.08723601081672516;-1.2210949545501535;-1.8079342094012274
HELO_2962B;5.797547310636699;3.441974394499338;2.680172932164233;3.9539437097154466;5.729101554096316;3.3774818306470085;0.34876477993738736;1.306871448523501;0.5637678600473093;2.0844857481600183;0.9479419595913692;0.03269087128514689;HELO_2962B;TRAP transporter small transmembrane protein;COG3090;TRAP-type C4-dicarboxylate transport system, small permease component YiaM;DctM;HELO_RS10870;G;;;;HELO_2962B;TRAP transporter small transmembrane protein;0.6138132108023826;-0.25032763011924675;0.62031270357775;0.6349130968174452;0.02109988601506263
HELO_2964A;21.725726300036836;19.0286241031797;37.45163518174983;17.745497447095545;76.63270313576446;43.41531970540723;2.01970271778871;2.4954307400638944;7.590421112991751;3.213024110685014;1.4623992615648163;8.69548104971577;HELO_2964A;TRAP transporter substrate-binding protein;COG1638;TRAP-type C4-dicarboxylate transport system, periplasmic component;DctP;HELO_RS10885;G;;;;HELO_2964A;TRAP transporter substrate-binding protein;0.18226308636701916;-0.20801242484833704;0.8056071465027239;-0.9667309731309759;-1.148994059497995
HELO_3046A;676.7629204246041;29.80649733135881;345.83251908462944;383.57517952316704;298.4812625442371;244.3534091943403;132.58835667596338;6.1385529005560135;40.58071161116993;102.85453345874103;68.68623177720777;79.44262343374517;rmf;ribosome modulation factor;COG3130;Ribosome modulation factor;Rmf;HELO_RS11310;J;rmf; ribosome modulation factor;;rmf;ribosome modulation factor;4.459474147112289;0.4993778544256058;0.2876044238003308;1.4659193930661152;-2.9935547540461735
HELO_3187A;27.334653298080923;19.740440214242895;19.25188060048953;23.315632645495555;22.31603232755678;20.76146822610244;2.069396200918908;1.311327424018052;3.099244228049416;2.251073969545638;2.2998522480379444;0.9240490472222816;HELO_3187A;uncharacterized protein;COG3791;Uncharacterized conserved protein;;HELO_RS12040;S;;ybbO;;HELO_3187A;uncharacterized protein;0.4501210342176636;-0.10372001351718829;0.09954640987756669;0.38079165261467995;-0.06932938160298363
HELO_3279A;147.93262876665497;6.908031417167467;86.43967144421475;120.25380889444257;93.31439233166441;70.74249543858421;22.619719673932398;2.489494808916094;5.8945567675076385;20.42007821498472;22.25308579561779;26.427090627212685;HELO_3279A;uncharacterized protein;;;;;;;;;HELO_3279A;uncharacterized protein;4.235197447183117;0.28546005225402915;0.3946500144615186;1.0537600271194751;-3.181437420063642
HELO_3280A;4.236762494352621;0.9173469898541639;3.412417922026885;21.471107819880725;0.8918755338781029;1.9709810173194577;1.7392807994525985;0.8006975695295084;1.9498776154210489;3.0447431451182734;0.2722236032547374;1.383241597339158;HELO_3280A;uncharacterized protein;;;;;;;;;HELO_3280A;uncharacterized protein;1.4495637241117159;0.570630054918648;-0.651122210123954;0.81773578766465;-0.6318279364470658
HELO_3289A;61.82494987502718;16.109186399383965;27.0270491703882;38.493198113762105;31.384120213297667;23.857451926930462;1.5968743870636473;1.121944187141292;4.575963024083264;4.347611310609748;2.853580413219395;3.6892774467758795;glxK;glycerate kinase;COG1929;Glycerate kinase;GlxK;HELO_RS12570;G;glxK; glycerate kinase;2.7.1.165;glxK;glycerate kinase;1.8765664586992932;0.17314144109452378;0.3816081335577177;1.337659198015686;-0.5389072606836072
HELO_3291A;55.05880599287256;33.23007873777749;57.45713493838259;0.0;105.6851840648161;59.182789458161174;4.207293290618006;4.154490134723324;10.446022754652065;0.0;8.955251892616298;12.490054843315095;HELO_3291A;DUF2971 domain protein;;;;;;;;;HELO_3291A;DUF2971 domain protein;0.7116764055502216;-0.0419718543157126;0.825936953480352;-0.10240996033469152;-0.8140863658849131
HELO_3291B;112.72067198698994;55.54905683145832;93.27932627766357;0.0;140.79606833968936;82.68600032756395;4.818161735557333;6.445972718066375;17.022508602398208;0.0;17.058840067431372;15.707316248794907;HELO_3291B;uncharacterized protein;;;;;;;;;HELO_3291B;uncharacterized protein;1.0079196620306616;0.1719551518508382;0.7607593283520817;0.44243632683144707;-0.5654833351992146
HELO_3291C;104.14025116245467;49.78970674413557;100.24575304261585;0.0;127.22566206034101;82.3874313265673;4.452403933717481;2.069137770391711;12.372497950226698;0.0;18.377179585293803;11.001742484896425;HELO_3291C;uncharacterized protein;;;;;;;;;HELO_3291C;uncharacterized protein;1.049707037302345;0.27995953933281204;0.6207831671411315;0.33441323320402017;-0.7152938040983248
HELO_3291D;47.46030552268885;55.7369445058385;60.97982720881219;0.0;104.94998686020881;56.09340022697435;2.9324346124407454;5.034398944183752;6.337425105144545;0.0;4.416809173816752;7.399212225791594;HELO_3291D;uncharacterized protein;;;;;;;;;HELO_3291D;uncharacterized protein;-0.22748495781558642;0.11847474755454357;0.8919875183352248;-0.23652048491238897;-0.009035527096802554
HELO_3291E;55.12926082250399;63.14862517567389;70.84798894376245;0.0;117.55813062331178;59.01988444843204;3.2617060444884927;9.308265024334432;11.283738066104402;0.0;4.879930001867615;12.091371258644505;HELO_3291E;DOPA dioxygenase family protein;COG3805;Aromatic ring-cleaving dioxygenase;DodA;HELO_RS12610;Q;;;;HELO_3291E;DOPA dioxygenase family protein;-0.19266528572423525;0.25950723415907984;0.9820821585592867;-0.0966874811469225;0.09597780457731275
HELO_3291F;55.88906423375854;69.31252921599052;88.97513334515422;0.0;153.92790540142383;101.1948971909622;3.304714956908113;5.666985459722127;3.5149415185820247;0.0;3.1651701090012474;16.346210969669674;HELO_3291F;uncharacterized protein;;;;;;;;;HELO_3291F;uncharacterized protein;-0.30563044029299924;-0.1837249208651084;0.6002738625454676;-0.8450999057356885;-0.5394694654426893
HELO_3291G;86.81521826471574;105.36406076187801;177.78314765307144;0.0;277.25800617985084;166.32463000299222;4.2527556796067305;10.92860425018249;26.140890357028;0.0;32.61577438319963;42.041020119915174;HELO_3291G;uncharacterized protein;;;;;;;;;HELO_3291G;uncharacterized protein;-0.2764678787597754;0.09556092835523877;0.733773373970867;-0.9301069404035536;-0.6536390616437782
HELO_3291H;96.7910717539146;64.57330766885536;183.2264712792925;0.0;286.89673318821815;152.4606497275678;5.844432844107312;9.05508830822573;39.31751865424831;0.0;57.238209751974004;39.71435391244447;HELO_3291H;uncharacterized protein;COG3593;Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains;YbjD;HELO_RS12625;L;;;;HELO_3291H;uncharacterized protein;0.5765940847325162;0.26361160726942945;0.907682650331731;-0.6500941087561962;-1.2266881934887124
HELO_3296A;27.279967957744603;30.373001844067698;40.43746758495761;0.0;35.74678424801457;24.549741533162514;2.0724014439592335;3.354599540936818;10.347544569081885;0.0;7.271494306409597;4.121659807354971;HELO_3296A;uncharacterized protein;;;;;;;;;HELO_3296A;uncharacterized protein;-0.14974309078681713;0.6976271400426315;0.5243093070097515;0.14647178890657475;0.2962148796933919
HELO_3299A;79.18158932904544;30.32119033772442;56.81581503144198;0.0;56.00587343971514;51.3659632907144;5.972537038926435;3.344882447831268;8.219267975255596;0.0;2.3714948633388047;6.201805464956008;HELO_3299A;uncharacterized protein;;;;;;;;;HELO_3299A;uncharacterized protein;1.3561319721407639;0.1428347870930322;0.12248117420855564;0.614641617576206;-0.7414903545645579
HELO_3299B;33.33070540832956;8.205058600646327;8.508184830315109;0.0;8.503667615096733;7.6837153899651325;1.403875497193981;1.2038949527946696;0.8403021978507761;0.0;1.1212501586783978;2.063111796283482;HELO_3299B;uncharacterized protein;;;;;;;;;HELO_3299B;uncharacterized protein;1.8990006901902214;0.13085750602146273;0.13017193746516043;1.9831151539979963;0.08411446380777488
HELO_3299C;17.547815197855357;5.688279228024759;2.60974540148748;0.0;2.863048413403235;1.763825159990712;1.3240990214062065;0.5764820770671946;0.4175113942752319;0.0;1.4567531062692076;0.49559137784722085;HELO_3299C;uncharacterized protein;;;;;;;;;HELO_3299C;uncharacterized protein;1.471542272867571;0.38523073265257457;0.48307340466479753;2.7465109989149625;1.2749687260473914
HELO_3301B;17.125255248529136;4.644053544193192;5.323655416631172;0.0;4.677359503326293;4.221463252637851;1.1704388235872538;0.4088125825952222;1.0936700602811464;0.0;1.7811140975284043;0.6368774174439036;HELO_3301B;uncharacterized protein;;;;;;;;;HELO_3301B;uncharacterized protein;1.6831977322738605;0.27630459421151343;0.12076593775016198;1.795475245391895;0.11227751311803447
HELO_3301C;8.012891823545953;3.4720014552247793;2.8847631104526177;0.0;3.2125557240156675;1.3911262433211513;1.8565149258578322;1.2791946887483525;2.6354445738614816;0.0;0.750905729006806;1.3363045014814183;HELO_3301C;uncharacterized protein;;;;;;;;;HELO_3301C;uncharacterized protein;1.0110694173291117;0.700136325555246;0.8170054690587405;1.9142997735302114;0.9032303562010997
HELO_3301D;157.34258876100102;78.10260117429628;126.23560888395677;0.0;112.21845070380277;120.27777372810117;5.633307870956753;6.342099242022723;13.22087737971089;0.0;26.832347841523493;14.265015848422705;HELO_3301D;uncharacterized protein;;;;;;;;;HELO_3301D;uncharacterized protein;1.0012523019517383;0.06918731240381693;-0.09920608872145209;0.38473416787652415;-0.6165181340752142
HELO_3520B;172.39343099428956;194.1360613863241;62.96745832555737;58.40661549052148;54.409065737927854;56.28122568211868;7.469465990656917;9.817515721710341;0.5891424606721087;2.777468540151005;3.767229857949319;5.780720363289046;HELO_3520B;uncharacterized protein;;;;;;;;;HELO_3520B;uncharacterized protein;-0.17043117128890728;0.15927579737206887;-0.04794032146825966;1.5979149748393775;1.7683461461282848
HELO_3542A;3.6097352822791646;1.178422433244541;0.09166810264238319;0.10538078027761295;0.11239544913534344;0.30271013210044545;0.2607544561502026;0.10987058010462428;0.15877381121004655;0.18252486558207795;0.19467462844193828;0.29773835688429284;HELO_3542A;CcoS family protein;COG3197;Cytochrome oxidase maturation protein, CcoS/FixS family;FixS;HELO_RS13990;O;;;;HELO_3542A;CcoS family protein;1.0814001607760602;-0.25498179982800473;-0.2278463558005564;1.8231678016480228;0.7417676408719627
HELO_3596A;140.87946129777632;314.75649565732107;124.36838565751951;20.515094414177135;39.677997614832364;49.07747485669936;15.015470779677168;53.55145036413515;53.472356561808;15.701286242497329;13.959403376812478;15.717717532298947;HELO_3596A;uncharacterized protein;;;;;;;;;HELO_3596A;uncharacterized protein;-1.1541466554243627;1.3239398656264711;-0.2999131526931684;1.5024320359213919;2.6565786913457545
HELO_3596B;227.88187096865818;494.4051916297564;290.7421337342974;136.45421111353264;156.90816946049173;241.62213564768322;23.466169694537584;83.34710796619355;81.0408253736254;12.969014940372977;29.803350799577927;55.82643140826373;HELO_3596B;probable glycosyltransferase%2C type 8 / DUF4422 domain protein;COG1442;Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase;RfaJ;HELO_RS14275;M;;;;HELO_3596B;probable glycosyltransferase%2C type 8 / DUF4422 domain protein;-1.1140057915091752;0.26598257611200893;-0.619625369147049;-0.08410798487970084;1.0298978066294744
HELO_3596C;190.14512622258223;369.1046799642119;143.5096739976252;79.21330780308405;65.74623744053804;107.28995613995163;11.310564586120016;8.263060983314604;13.977485833887405;24.10860632457416;7.744640914184866;25.642715394889883;HELO_3596C;ABC-type transport system ATP-binding protein;COG1134;ABC-type polysaccharide/polyol phosphate transport system, ATPase component;TagH;HELO_RS14280;G;;;;HELO_3596C;ABC-type transport system ATP-binding protein;-0.9532649634824564;0.41626663552568655;-0.6981410217461717;0.8197689754819457;1.773033938964402
HELO_3969A;32.8774896909228;15.846629657323476;21.016243563802572;16.42049155235622;32.888177258349636;25.111347304168913;5.303002764887196;2.001365444684801;0.7631166746186492;2.8828327520331545;4.697257460632822;7.587814279371021;HELO_3969A;DUF2291 family protein;COG5618;Predicted periplasmic lipoprotein;;HELO_RS16190;S;;;;HELO_3969A;DUF2291 family protein;1.0078669812824481;-0.24610856469901066;0.3761051403939426;0.37565007512718296;-0.6322169061552652
HELO_3970A;55.585767884187824;25.499115845990346;49.5610729824817;28.952687813035322;60.4481706253221;44.73423858431721;3.2812382769367026;0.7698967586445582;4.5095546587744995;2.657432359206418;1.9025258694123222;6.943152217215975;HELO_3970A;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS16200;I;;;;HELO_3970A;probable oxidoreductase (short-chain dehydrogenase family);1.094495016245319;0.1447524477420652;0.4260954284654739;0.3071646083349666;-0.7873304079103525
HELO_3970B;59.039307711487254;28.361782509610986;54.33793097647476;38.36122234543175;68.79086645807291;54.59527993409089;2.5837882057818233;1.5057271545218411;0.7004048809383931;1.7410061475732637;4.895045553056219;5.147017399247289;HELO_3970B;probable oxidoreductase (short-chain dehydrogenase family);COG1028;NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family;FabG;HELO_RS16205;I;;;1.1.1.-,1.1.1.76,1.1.1.304;HELO_3970B;probable oxidoreductase (short-chain dehydrogenase family);1.0319677872488997;-0.006693698450100705;0.32807584040846827;0.11094493928490134;-0.9210228479639984
HELO_4036A;8.762052528388114;4.467603467592834;2.3005842298827583;2.61851352088595;1.6255737494093794;1.730751626822902;0.6558788787299165;1.5194371288517667;0.846660845960055;0.24329431153527076;0.6385064286908019;0.8869744280957084;HELO_4036A;uncharacterized protein;;;;;;;;;HELO_4036A;uncharacterized protein;0.8362758979743692;0.27342331469144665;-0.05666538106353314;1.8378864137371227;1.0016105157627535
HELO_4036B;6.433216172857835;1.492308456894228;2.610195910501787;5.814680356686108;2.813113076749314;2.630246869957323;1.3306076444422588;0.613452418376035;1.663363232443323;1.1384490989082867;1.6767193893550125;0.6804802589567636;HELO_4036B;uncharacterized protein;;;;;;;;;HELO_4036B;uncharacterized protein;1.576503932652225;-0.007990531683596203;0.07090165434269102;1.033918905042442;-0.542585027609783
HELO_4039A;29.673749716089805;10.129412223095839;4.131865470415986;6.205522569598536;3.9457249738206386;4.276803281121731;1.9417927369989423;1.3861031816842657;1.3249957842536075;1.2153069445964026;0.880688980282815;1.7352912638825875;HELO_4039A;zinc finger domain protein;COG1734;RNA polymerase-binding transcription factor DksA;DksA;HELO_RS16595;K;;;;HELO_4039A;zinc finger domain protein;1.462627138073064;-0.040180849646807015;-0.09348218564076971;2.539268433737846;1.076641295664782
HELO_4039B;148.073246442504;80.37223607451988;107.97576119688104;108.58487095017169;80.82170421799374;77.96873381466018;17.18616126670222;1.9100637631971664;29.00316831823831;35.49226443120783;16.564888747804403;3.7665422641552393;HELO_4039B;uncharacterized protein;;;;;;;;;HELO_4039B;uncharacterized protein;0.873412825350858;0.4646538174907242;0.05120202825348397;0.9166679028770313;0.0432550775261733
HELO_4039C;8.420353032911049;2.5937867706578595;4.070787694981116;4.797780063253911;7.287056080798401;4.898882045757319;0.9537510657711287;1.2742236804581935;1.2481911271437176;2.3867199776638515;2.9628133824132443;0.6274795696304193;HELO_4039C;uncharacterized protein;;;;;;;;;HELO_4039C;uncharacterized protein;1.3902763143544843;-0.21823168872769694;0.490418124047058;0.6753395653646437;-0.7149367489898406
HELO_4063A;6.83479734263906;4.517054342153251;2.6775864720136293;6.6298542969461165;2.877001539947513;3.1823020833686715;1.6547575524415923;1.2244174934744287;0.8179484224008955;1.2330699931740536;0.6123256330033974;1.622553062023096;HELO_4063A;uncharacterized protein;;;;;;;;;HELO_4063A;uncharacterized protein;0.5059977671019382;-0.1855380057372651;-0.10935596193813168;0.9055986879047726;0.3996009208028344
HELO_4063B;113.50964541970102;78.0384956167484;192.19806095401134;246.96573954899813;149.85889329487478;182.56321248627293;3.641021176990118;10.261105369922252;18.292849177447756;7.68666703382866;17.82875721104552;19.15341919260396;HELO_4063B;uncharacterized protein;;;;;;;;;HELO_4063B;uncharacterized protein;0.5348417323874441;0.0738036542665208;-0.28307721284499454;-0.680807835195024;-1.2156495675824681
HELO_4067A;10.743956624868133;4.091294678098568;7.158135993241401;7.200129650573111;5.803733066869104;6.716605874046043;0.422243146657783;0.8653995434352242;0.7309075401760533;0.5195574326009672;1.5578576770455728;1.8362667503494903;HELO_4067A;uncharacterized protein;;;;;;;;;HELO_4067A;uncharacterized protein;1.2058140702443114;0.08027313462623242;-0.18163988154527777;0.6058802178201095;-0.5999338524242019
HELO_4067B;61.672072607489916;57.25921924965876;135.52359455419443;133.20497750959885;133.4328678875168;137.2315851142569;4.006598956383381;7.874025209605034;4.750889284690172;12.532728009091036;7.037339691092797;4.8595412328279375;HELO_4067B;uncharacterized protein;;;;;;;;;HELO_4067B;uncharacterized protein;0.10533633721571078;-0.01793699580404251;-0.040201390829809114;-1.1411926909091719;-1.2465290281248826
HELO_4076A;131.2727230145109;116.65649670911677;128.4448184576478;127.55073648341056;51.13696191519179;103.55625460373454;8.623894485610263;9.30397485306359;36.442185285291956;13.871342169810024;3.9227332032032693;18.2749153962321;HELO_4076A;DUF3304 family protein;;;;;;;;;HELO_4076A;DUF3304 family protein;0.1689345980231538;0.30805784960514515;-1.0039009443733065;0.339236215742722;0.1703016177195682
HELO_4076B;81.75547341327537;123.52381000297483;210.31689286645368;275.20631706584703;77.01738400907027;156.1503226472906;7.766025657110793;8.250290693781372;43.86108261208766;57.78736196190321;9.419246480183936;22.049732032784448;HELO_4076B;DUF4123 domain protein;;;;;;;;;HELO_4076B;DUF4123 domain protein;-0.5894949846822808;0.4272628680942887;-1.0102777046917826;-0.9252185947049139;-0.33572361002263307
HELO_4080A;560.6302690585683;286.93629071467006;385.29298329068314;407.4586361002426;430.07963027596514;417.7275407686093;38.23879748797774;53.80674877809904;37.50485654084675;25.637892003799337;36.30453571557438;92.25161356859158;HELO_4080A;uncharacterized protein;;;;;;;;;HELO_4080A;uncharacterized protein;0.9638710580157817;-0.116316338514876;0.041942581833883;0.423608880876877;-0.5402621771389047
HELO_4083A;68.05922399805932;41.84174492097816;49.131193251283726;42.34666379570778;53.66527929713363;44.48713556819945;6.469733481604931;5.382298338322355;4.1088828537095266;3.094221719881097;5.822728695908002;1.3355742422100747;HELO_4083A;uncharacterized protein;;;;;;;;;HELO_4083A;uncharacterized protein;0.688816881594664;0.14024998678643996;0.265166207210922;0.6023755354705731;-0.08644134612409093
HELO_4083B;180.37164679490797;166.86971855013766;187.86810056311597;142.6673521269681;216.1531341248899;190.1638979292252;5.147587361481549;10.141626559340684;1.2952355588818665;5.901161934099104;7.822818502699334;28.39458639803759;HELO_4083B;uncharacterized protein;COG0645;Predicted kinase, contains AAA domain;;HELO_RS16870;R;;;;HELO_4083B;uncharacterized protein;0.1116069310711918;-0.01743103623121467;0.18390268476853944;-0.07586114833923308;-0.18746807941042487
HELO_4083C;107.2775572181565;111.71010942228436;118.55386338347107;100.01078260956052;130.0383977647476;122.37710183105446;2.6033107171185246;12.237057411339991;9.12288136972751;11.02744382046198;3.3766230458823636;10.464624434753796;HELO_4083C;probable S-adenosylmethionine-dependent methyltransferase;COG2226;Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG;UbiE;HELO_RS16875;H;;;;HELO_4083C;probable S-adenosylmethionine-dependent methyltransferase;-0.05788267712733841;-0.045413910897616816;0.08691495965523721;-0.18834041709769433;-0.13045773997035592
HELO_4089A;30.107050434103087;15.271041599394989;17.026206622507857;17.29798187966742;17.542432796994397;20.331661664521445;3.9632447798006867;1.9071184415826412;3.9035334918284863;3.655290437047271;4.896542074758726;3.868123886083454;HELO_4089A;uncharacterized protein;;;;;;;;;HELO_4089A;uncharacterized protein;0.9349349963699582;-0.24290051857369477;-0.202165810844682;0.5442452540928802;-0.3906897422770781
HELO_4090A;38.408684371989835;8.710442867976482;23.602878041699615;29.76586968905743;34.341858835334925;20.05103342316264;1.812900575543454;1.7785881258327123;3.059583081628544;1.8758944644727968;14.575696504157504;6.888534037264781;HELO_4090A;uncharacterized protein;;;;;;;;;HELO_4090A;uncharacterized protein;2.0209045872214246;0.22493603288395647;0.7474868628224254;0.9046225281936167;-1.116282059027808
HELO_4091A;253.65786320831288;145.9988963991541;474.85884844985804;640.8411473920231;398.834757139663;354.44620505992634;17.045515373132865;17.422557191516844;85.76341775626224;60.271336440576505;143.5327893712747;62.926510958925476;HELO_4091A;uncharacterized protein;;;;;;;;;HELO_4091A;uncharacterized protein;0.7927549407925927;0.42090246586585955;0.16977265727292767;-0.481070967155115;-1.2738259079477077
HELO_4098A;14.954599326937311;4.7008117147035575;93.92772339869428;171.79201950808746;25.2846299139366;58.229319792792175;0.8179379950982306;1.964647643757622;22.914611572994065;19.35323293764561;13.683025279960392;37.79500250926125;HELO_4098A;alpha/beta hydrolase fold protein;COG0596;2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold;MenH;HELO_RS16990;HR;;;2.4.1.-;HELO_4098A;alpha/beta hydrolase fold protein;1.4847331198802105;0.6805179662910152;-1.172092095896721;-1.8923391396865838;-3.3770722595667944
HELO_4157A;225.1954713602504;183.67272113552747;231.23680558173191;264.9023589307697;187.02775148773722;210.15026925385007;12.395510139002901;12.32153423605528;19.720327991857;10.708152208146643;20.71696186026716;21.609697440303158;HELO_4157A;LysE family transport protein;COG1280;Threonine/homoserine/homoserine lactone efflux protein;RhtB;HELO_RS17330;E;;;;HELO_4157A;LysE family transport protein;0.2925992706655274;0.13732654610602069;-0.16732447823132457;0.09929995871450892;-0.19329931195101846
HELO_4189A;49.53057502463201;23.407895474021057;70.26324051147269;75.68074697435165;35.339394484311384;66.0577973432487;4.3994171665194255;1.6760824678189976;19.602157406369685;2.4832315552694095;4.507202552119187;10.903300004049894;HELO_4189A;uncharacterized protein;;;;;;;;;HELO_4189A;uncharacterized protein;1.0498086907885966;0.08775299228064615;-0.8838707150580438;-0.40824849796748275;-1.4580571887560794
HELO_4196A;14.58287821678328;18.181783102360004;20.017949870200137;6.861894651173717;8.78002158077984;20.671063054764378;2.3599408146123855;0.6160642506424922;6.099860958079761;2.329622553199256;2.2615683668613955;6.930333755384604;HELO_4196A;zinc finger domain protein;COG1734;RNA polymerase-binding transcription factor DksA;DksA;HELO_RS17570;K;;;;HELO_4196A;zinc finger domain protein;-0.2997751075338071;-0.04414797227857381;-1.147860371520507;-0.4758081960277316;-0.17603308849392452
HELO_4197A;17.23777344242777;8.248542253944267;22.67272390708173;9.753535152874756;10.02106131870013;27.90924045808916;3.7697373561864946;4.698678620546415;3.130712771706918;3.4849143600111896;4.059180803813036;5.059090369558107;HELO_4197A;uncharacterized protein;;;;;;;;;HELO_4197A;uncharacterized protein;0.9796317164087331;-0.28830498527524906;-1.391267544028019;-0.6646010960069804;-1.6442328124157135
HELO_4197B;475.44653586896357;298.5097746903437;310.0452710932723;260.00930535022513;204.97773451038816;294.81089890928814;21.796720600724633;12.07160196287388;18.898761034675797;27.334482327486036;9.135786097232575;15.115685276310442;HELO_4197B;peptidase S24 family protein;COG1974;SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase);LexA;HELO_RS17580;KT;;;;HELO_4197B;peptidase S24 family protein;0.6697112451089371;0.07244936440223881;-0.5221868128983562;0.6876391238251145;0.017927878716177403
HELO_4197C;437.68679235206235;428.8136471171852;930.3048760634614;799.6821009895751;657.8206406277059;868.527135345906;30.181052185843416;52.7948933727136;124.27765789200576;101.3112136115624;83.54547625594932;199.84138105673475;HELO_4197C;peptidase S49 family protein;COG0616;Periplasmic serine protease, ClpP class;SppA;HELO_RS17585;O;;;;HELO_4197C;peptidase S49 family protein;0.0294799805946262;0.09902248166525673;-0.40034529551971865;-0.9870397789922798;-1.016519759586906
HELO_4197D;89.42069813712187;72.62225508974235;93.97893595695848;56.81959961351668;82.10432370167318;96.35028709826277;14.923846056683084;16.651698796140543;19.053068368637597;4.633234116198955;10.603848837552542;13.157285111810678;HELO_4197D;uncharacterized protein;;;;;;;;;HELO_4197D;uncharacterized protein;0.2965111157978715;-0.03557763977625594;-0.22826169502484195;-0.10653217691035977;-0.40304329270823125
HELO_4289A;120.0607529138768;46.8470133309166;46.04756024962572;47.64030761888015;53.97894401667452;47.04778704129935;4.577806426200242;2.551658310040515;1.7781176924825932;5.188092492869098;4.826547214477833;2.8240756080640126;HELO_4289A;uncharacterized protein;;;;;;;;;HELO_4289A;uncharacterized protein;1.3392304509049033;-0.03035007476770435;0.19440921153131274;1.333189337968145;-0.006041112936758353
HELO_4289B;35.078060781987354;11.765947517210945;7.477246075204117;5.765139613909759;7.7469249773275095;6.2556466609207355;2.1951896572801;0.7635926717363044;0.6557963383473981;1.6386616422268545;0.8157404729615019;2.2627666804165947;HELO_4289B;uncharacterized protein;;;;;;;;;HELO_4289B;uncharacterized protein;1.4988211731536896;0.22449146536021924;0.2696717193408955;2.3139456893181047;0.8151245161644152
HELO_4299A;4.830347250946256;0.5050836668557802;5.543195541408269;11.1284839556077;14.398734912014787;4.185364149845063;0.4496811504830356;0.2155076371989651;0.692299005601764;2.1821974685575203;3.1648645315931256;0.6715822293782483;HELO_4299A;uncharacterized protein;;;;;;;;;HELO_4299A;uncharacterized protein;1.9537381238618101;0.3355500778632976;1.570294617620923;0.16913650379574285;-1.7846016200660673
HELO_4335A;15.512003147901495;827.7507630338865;58.12721540334937;3.280484017512947;192.25123508111253;152.96663551002712;0.49246382091569224;54.45246517399685;25.263582529026948;1.9383528672432417;96.65377328959649;178.0770341169528;cheY;chemotaxis-specific response regulator CheY;COG0784;CheY-like REC (receiver) domain, includes chemotaxis protein CheY  and sporulation regulator Spo0F;CheY;HELO_RS18340;T;cheY; chemotaxis-specific response regulator CheY;;cheY;chemotaxis-specific response regulator CheY;-5.649351237493985;-1.38072351344118;0.3278598810141684;-3.221030697496011;2.4283205399979737
HELO_4345A;587.9318811335213;1879.3187096635647;153.55729445376028;37.87932615617268;1115.1756782301243;1000.201645192008;43.90696941894037;31.06282711977697;68.54340929264349;4.367900996319551;947.0937679737059;1466.7440943726742;flhD;flagellar transcription regulator FlhD;;;;;;;;;flhD;flagellar transcription regulator FlhD;-1.6748045367469686;-2.6955189167533353;0.15683154832582247;-0.7655598874543532;0.9092446492926154
HELO_4366A;68.01139717291892;410.031889740731;20.395376785840774;1.2124006829555833;150.42646842357405;124.77470620042347;5.348942908036924;8.233837807027664;11.661276661013002;0.40919675487481144;131.90751666403168;175.83043425229747;fliN;flagellar motor switch protein FliN;COG1886;Flagellar motor switch/type III secretory pathway protein FliN;FliN;HELO_RS18505;NU;fliN; flagellar motor switch protein FliN;;fliN;flagellar motor switch protein FliN;-2.574343782627156;-2.5554708285567607;0.26777558205584207;-0.8659352730823775;1.7084085095447783
HELO_4382A;64.12951743131568;318.50628932809803;91.89720183500908;46.87918670902983;289.26124377009813;194.2797592213375;1.0701886754108718;44.78746223945953;14.989629941026362;5.06578226291953;184.32144406511225;170.54400505669116;flgM;flagellin synthesis regulator FlgM;COG2747;Negative regulator of flagellin synthesis (anti-sigma28 factor);FlgM;HELO_RS18590;KN;flgM; flagellin synthesis regulator FlgM;;flgM;flagellin synthesis regulator FlgM;-2.294460887846591;-1.0718353745716422;0.5718095320556538;-1.5841589790339974;0.7103019088125935
HELO_4398A;195.24104545855334;102.98694358709253;292.99563123836384;303.9888728267954;366.8068810264418;245.0073114916995;7.932577390127049;6.231608576538286;34.38046842346425;44.72720694379485;15.977991593412622;15.560935827315152;HELO_4398A;uncharacterized protein;;;;;;;;;HELO_4398A;uncharacterized protein;0.9162244273191043;0.25709352283478815;0.5802472763111997;-0.3260743691321517;-1.242298796451256
HELO_4398B;362.33005686933194;205.73774058201812;414.454305555631;387.313834002807;582.5227517369464;410.663436899147;13.598469991976643;10.367709422780546;47.916727509484026;5.108566029392209;31.849061761867357;32.94846967781131;HELO_4398B;uncharacterized protein;;;;;;;;;HELO_4398B;uncharacterized protein;0.8134789381631231;0.013224491328122312;0.503323591026712;-0.1801845979516088;-0.9936635361147319
HELO_4410A;69.84854386099238;33.77815168633252;65.89444112605885;102.6342756170762;42.88591289787184;37.55258739224764;2.5504734973220433;3.8691912871368035;15.44171143873229;31.72464531096953;4.521750353225777;5.056101106436188;HELO_4410A;uncharacterized protein;;;;;;;;;HELO_4410A;uncharacterized protein;1.02655694050378;0.7950586416092023;0.18693023058460945;0.8779105145154249;-0.1486464259883551
HELO_4410B;31.79086135902908;17.774358011479563;20.13203074738935;31.50298309638252;9.377333554234342;14.591155731381136;4.32235507443003;1.7051453023126804;3.7650272500162982;9.306891647200128;1.7462898757049043;2.106421685432967;HELO_4410B;uncharacterized protein;;;;;;;;;HELO_4410B;uncharacterized protein;0.8045302236479248;0.4387035389553966;-0.5872920829645927;1.0725659241343215;0.2680357004863967
HELO_4414A;153.76683292970367;123.29448974836895;151.69198927140778;165.69327339950075;158.97032447136812;137.28627596695932;12.169152779845007;13.800440767663286;4.293162383262483;7.0983382964184205;6.6546701481396715;10.5012964000472;ubiC;chorismate--pyruvate lyase;COG3161;4-hydroxybenzoate synthetase (chorismate-pyruvate lyase);UbiC;HELO_RS18770;H;ubiC; chorismate--pyruvate lyase;4.1.3.40;ubiC;chorismate--pyruvate lyase;0.31633399012094543;0.142966390260435;0.2101463153937715;0.1624383447547615;-0.15389564536618394
HELO_1605;64.35145112693232;22.916219920330445;70.30371313173626;77.58530091692907;99.1673403705073;79.91107589446392;1.5320131402372346;0.46866292739974114;4.143120920603009;5.0198292966191485;5.3880877926048125;5.776246529367461;pykA2;pyruvate kinase;COG0469;Pyruvate kinase;PykF;HELO_RS03190;G;pykA2; pyruvate kinase;;pykA2;pyruvate kinase;1.4502298890773222;-0.18235999950778758;0.3080030820969455;-0.3081179349180587;-1.758347823995381
HELO_1905;55.81229368162527;55.15123742977293;78.73364063866097;76.10917474734492;114.92840536204274;79.26105876407773;4.076298982282317;3.210799590010018;8.430501785360368;2.144329526615761;8.480233574361433;7.716649063818791;puuC1;aldehyde dehydrogenase PuuC;COG1012;Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase;AdhE;HELO_RS04900;I;puuC1; aldehyde dehydrogenase PuuC;;puuC1;aldehyde dehydrogenase PuuC;0.016885333766222033;-0.009511643486316501;0.5304620133943505;-0.4984970375066613;-0.5153823712728833
HELO_3064;50.01130102693506;56.186362041980665;32.06879591359829;34.262982544974534;39.32109860279993;33.27881508927023;0.8327770974985941;2.3265478156631074;2.6869274312325535;2.1956093079748653;2.345356500596171;5.013841412300866;HELO_3064;NUDIX family hydrolase;COG1051;ADP-ribose pyrophosphatase YjhB, NUDIX family;YjhB;HELO_RS11405;F;;rluE;;HELO_3064;NUDIX family hydrolase;-0.16485423353434125;-0.05184672517598976;0.23421770666235098;0.5734996557939125;0.7383538893282537