ID NES pvalue p.adjust core_enrichment GOBP_DETOXIFICATION_OF_INORGANIC_COMPOUND 2.215673656 8.92E-09 1.85E-06 MT1X/MT2A/MT1M/MT1G/MT1E/MT1A/MT1F GOBP_STRESS_RESPONSE_TO_METAL_ION 2.195897527 3.13E-08 5.41E-06 MT1X/MT2A/MT1M/MT1G/MT1E/MT1A/MT1F/HSPA5 GOBP_CELLULAR_RESPONSE_TO_ZINC_ION 2.218904571 1.22E-06 0.000103605 MT1X/MT2A/MT1M/MT1G/MT1E/MT1A/MT1F/KCNK3 GOBP_INTERLEUKIN_5_PRODUCTION 1.967214314 6.93E-05 0.002474992 IL1RL1/IL1RAP/IL33/TSLP/RARA/PDE4D GOBP_PEPTIDYL_PROLINE_HYDROXYLATION_TO_4_HYDROXY_L_PROLINE 1.827543073 0.000586614 0.010764819 EGLN3/ERO1A/P4HA1/P4HB/P4HA3/PRDX4/P4HA2 GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN 1.825581804 0.000624156 0.011152305 SERPINE1/SNAI2/CYP1B1/MUC1 GOBP_INFLAMMATORY_RESPONSE_TO_WOUNDING 1.965377995 0.000104062 0.003284555 HMOX1/TIMP1/HIF1A/SIGLEC10 GOBP_CELLULAR_RESPONSE_TO_COPPER_ION 2.175700668 1.95E-06 0.000155722 MT1X/MT2A/MT1M/MT1G/MT1E/MT1A/MT1F GOBP_FIBRINOLYSIS 1.966209552 0.00012559 0.003701039 THBD/SERPINE1/PLAUR GOBP_RESPONSE_TO_PEPTIDOGLYCAN 1.818194982 0.002021113 0.026457439 IL6/C5AR1/MYD88/RELA/IRAK3/NOD2 GOBP_NEGATIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION 2.011042019 6.40E-05 0.002339804 BCL6/IL4R/SMAD7/ZBTB7B/LOXL3/ZC3H12A/JAK3 GOBP_ACUTE_PHASE_RESPONSE 2.277194884 1.22E-07 1.43E-05 SERPINA3/SERPINA1/CD163/IL6/SAA1/PLSCR1/ASS1/SAA2/CEBPB/FN1/APOL2/PTGES/PTGS2/ORM2/LBP GOBP_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT 1.714842831 0.004610369 0.045003574 HIF1A/CDKN1A/KLF5/SRC/TIGAR/IL6ST/TYMS GOBP_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_OXIDATIVE_STRESS 1.787744944 0.002895088 0.032909798 HMOX1/HIF1A/SESN2/SIN3A/ATF4/EPAS1/ARNT GOMF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING 1.880411545 0.000595581 0.010824861 VEGFA/ITGA5/ITGB3/PDGFRA/IL1R1/PDGFA/ERN1/PTEN GOMF_PEPTIDE_DISULFIDE_OXIDOREDUCTASE_ACTIVITY 1.818346728 0.001419507 0.02015182 GLRX/TXN/PDIA4/GSTO1/P4HB/PDIA6/GLRX2 GOBP_COPPER_ION_TRANSPORT 1.835325306 0.001289836 0.018871065 CP/STEAP3/STEAP2/STEAP4/FKBP4/SLC31A1/ATOX1/CUTC/SLC11A2 GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION 1.823446802 0.00149398 0.020865554 IL6/SLC7A5/MYD88/NOD2/SPHK1 GOBP_TOLL_LIKE_RECEPTOR_2_SIGNALING_PATHWAY 1.885484074 0.000872988 0.01401106 TLR2/TNIP2/TNFAIP3/IRAK1/NOD2/PIK3AP1/LYN/MFHAS1/F2RL1/TLR1/RIPK2 GOBP_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION 1.854072563 0.001146008 0.017253936 HIF1A/CDKN1A/SAV1/KLF5/SRC/TIGAR/IL6ST/TYMS/PYY GOBP_NEUROEPITHELIAL_CELL_DIFFERENTIATION 1.790860895 0.004337805 0.043087017 FAM20C/SERPINE1/SOX4/BMP2/CEBPB GOBP_REPLICATIVE_SENESCENCE 1.807258338 0.001809475 0.024353497 SERPINE1/CDKN1A/CHEK2/ROMO1/ERCC1 GOBP_T_HELPER_17_CELL_LINEAGE_COMMITMENT 1.745102213 0.003761991 0.039580475 IL6/STAT3/LOXL3/BATF GOBP_ZINC_ION_HOMEOSTASIS 2.165568062 2.95E-06 0.000208643 MT1X/MT2A/MT1M/MT1G/MT1E/MT1A/MT1F/S100A9/SLC39A14/S100A8/SLC39A8/SLC39A4 GOBP_GLYCOLYTIC_PROCESS_THROUGH_FRUCTOSE_6_PHOSPHATE 2.014515662 0.000118688 0.003548091 HK2/PGK1/TPI1/GAPDH/ENO1/PKM/ALDOC/HK3/PFKP/GPI/ENO2 GOBP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 1.818873141 0.002158245 0.0276131 ESM1/HGF/PTPN1/PTPN2 GOBP_PROTEIN_DNA_COMPLEX_DISASSEMBLY 1.864965538 0.000772291 0.012839852 MYC/SMARCC1/HMGA1/SET/SMARCD2/SMARCA4/RPL23/GRWD1/SMARCB1/SUPT16H/SMARCD1 GOBP_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION 1.96063525 0.000595554 0.010824861 BCL6/IL4R/SMAD7/ZBTB7B/LOXL3/ZC3H12A/JAK3/CBFB GOBP_T_HELPER_2_CELL_DIFFERENTIATION 1.742743113 0.004160865 0.041864492 BCL6/BCL3/IL4R/RARA/BATF GOCC_PRERIBOSOME_SMALL_SUBUNIT_PRECURSOR 1.776377168 0.003464049 0.037525183 NOP14/FAM207A/NOB1/TSR1/RRP1B/BYSL/LTV1/UTP20/RRP1/NOP9/NOC4L GOCC_TELOMERASE_HOLOENZYME_COMPLEX 1.944990878 0.000754365 0.012575453 DKC1/GAR1/ACD/NAT10/NOP10/SMG7/SMG6/HNRNPC/NHP2/WRAP53/GNL3L/PTGES3/TEP1/TERC/SNRPE/HNRNPU GOBP_RESPONSE_TO_COPPER_ION 2.094804322 1.70E-05 0.000879033 MT1X/MT2A/MT1M/MT1G/MT1E/MT1A/MT1F/LOXL2/ICAM1 GOBP_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS 1.906646289 0.000532632 0.01031746 HK2/TKT/HK3/PGD/GPI/H6PD/TALDO1/PGAM1/TIGAR/PGM2 GOBP_AMP_METABOLIC_PROCESS 1.731300045 0.005210427 0.04921492 ADK/NT5E/AK1/PRPS2/AK4/AK2/AMPD2 GOMF_SNORNA_BINDING 2.064817548 4.10E-05 0.001689331 DDX21/NOP14/NOLC1/NUDT5/NUFIP1/DHX37/TSR1/DKC1/GAR1/HEATR1/NOP10/BYSL/RRP9/WDR3/IMP4/NHP2/NUDT1/TBL3/ISG20/NOP58/IMP3 GOBP_T_HELPER_17_TYPE_IMMUNE_RESPONSE 2.008485269 6.46E-05 0.002349382 IL6/NFKBIZ/STAT3/SMAD7/ZBTB7B/LOXL3/ZC3H12A/BATF/ENTPD7/PHB/RORA GOBP_REGULATION_OF_ASTROCYTE_DIFFERENTIATION 1.892833306 0.000714724 0.012194417 LIF/IL6/BMP2/CLCF1/LDLR/NOG/NR1D1/SERPINE2 GOBP_CD40_SIGNALING_PATHWAY 1.750067121 0.005139735 0.049010788 ITGA5/TNIP2/TNFAIP3/CD40/PHB2/PHB GOMF_DNA_POLYMERASE_BINDING 1.881356335 0.000905922 0.014406711 NABP2/ACD/NAT10/RMRP/LONP1/SMG6/SMARCA4/HSP90AB1/RAD51/POLG2/PTGES3/TERC/PCNA/CDT1 GOBP_GLUCOSE_CATABOLIC_PROCESS 2.043148133 5.86E-05 0.002193944 HK2/PGK1/TPI1/GAPDH/ENO1/PKM/ALDOC/HK3/PFKP/GPI/ENO2/PGAM1/TIGAR GOMF_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 1.957544863 0.000110439 0.003416451 SLC38A5/SLC6A6/SLC7A5/SLC6A9/SLC43A2/SLC3A2/SLC7A11/SLC38A1/SLC1A5/SLC38A6/SLC38A2/SLC7A8 GOMF_PROTEIN_DISULFIDE_ISOMERASE_ACTIVITY 1.788844627 0.002389992 0.029462598 ITGB3/ERO1A/PDIA4/P4HB/PDIA6/QSOX2/GLRX2/ERO1B GOBP_CHROMATIN_DISASSEMBLY 1.775656832 0.003046773 0.034079744 SMARCC1/HMGA1/SET/SMARCD2/MAP1S/SMARCA4/GRWD1/SMARCB1/SUPT16H/SMARCD1 GOBP_REGULATION_OF_T_HELPER_17_TYPE_IMMUNE_RESPONSE 1.790792625 0.003814659 0.039797902 NFKBIZ/SMAD7/ZBTB7B/LOXL3/ZC3H12A GOCC_90S_PRERIBOSOME 1.926943063 0.000194649 0.004962257 NOP14/WDR12/FAM207A/SRFBP1/HEATR1/NOC2L/KRI1/UTP20/WDR3/IMP4/PES1/RRP36/TBL3/NOP9/RSL1D1/IMP3/NOC4L GOBP_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE 1.786475772 0.004185003 0.041971531 HMOX1/PPIF/GSTO1/ZC3H12A/MAPK13/SLC38A2/DAXX/ATF4/MKNK2 GOBP_RESPONSE_TO_ZINC_ION 2.180430154 1.15E-06 9.97E-05 MT1X/MT2A/SOD2/MT1M/MT1G/MT1E/MT1A/MT1F/ASS1/KRT14/S100A8/KCNK3/PTEN GOBP_TETRAHYDROFOLATE_METABOLIC_PROCESS 1.759479966 0.003630579 0.038722023 MTHFD2/SHMT2/GCH1/GART/MTHFR/ATIC/TYMS GOBP_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE 1.89649649 0.000736443 0.012409771 IL1R1/IL1RL1/SLC11A1/IL4R/IL33/HAVCR2/IL18R1/JAK3 GOCC_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR 1.855264207 0.000991869 0.015418611 MRTO4/RRS1/WDR12/RPF1/WDR74/NOC2L/RRP1B/MAK16/NIP7/ZNF622/EBNA1BP2/PES1/RRP1 GOBP_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION 1.863343347 0.001215802 0.018085787 BCL6/IL4R/SMAD7/ZBTB7B/LOXL3/ZC3H12A/JAK3/CBFB GOBP_RNA_5_END_PROCESSING 1.833417915 0.001402905 0.0199617 RPP40/NOP14/POP1/UTP20/RPP25/SSB/THG1L/TBL3/NOP9/ABT1/PNPT1/RPP21/TRMT10C/RPP30 GOCC_SNO_S_RNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX 1.933822259 0.000484778 0.009692436 SNORA62/RPP40/NOLC1/SNRPF/POP1/DKC1/GAR1/RMRP/NOP10/RRP9/RPP25/FBL/NHP2/NOP58/TERC/LSM6/MPHOSPH10/SNORA74A/RPP30 GOBP_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION 1.856490958 0.000944315 0.014827659 BCL6/IL4R/ARG2/SMAD7/ZBTB7B/LOXL3/ZC3H12A/JAK3/CBFB/CD274 GOBP_CELLULAR_RESPONSE_TO_CADMIUM_ION 1.944946252 0.000453446 0.009214141 MT1X/MT2A/HMOX1/MT1M/MT1G/MT1E/MT1A/MT1F/AKR1C3 GOCC_PRERIBOSOME 2.227184423 3.32E-08 5.57E-06 MRTO4/RRS1/NOP14/WDR12/FAM207A/RPF1/NOB1/TSR1/SRFBP1/WDR74/UTP3/HEATR1/PDCD11/NOC2L/DCAF13/RRP1B/KRI1/BYSL/MAK16/RRP9/NOL10/LTV1/UTP14A/UTP20/WDR3/NIP7/ZNF622/EBNA1BP2/IMP4/FBL/FCF1/KRR1/PES1/RRP36/TBL3/RRP1/NOP58/NOP9/RSL1D1/IMP3/NOC4L GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION 1.826106206 0.001967726 0.025867491 NABP2/CCT2/DKC1/GNL3/ACD/TCP1/CCT4/CCT5/WRAP53/GNL3L/TERF2/TINF2/CCT8/PINX1/XRCC5/POT1/TPP1/CCT6A/TNKS GOCC_NUCLEOID 1.985586757 4.84E-05 0.001929265 SOD2/SHMT2/TOP1MT/TFB2M/VDAC1/LONP1/ACADVL/TFAM/SLC25A5/POLDIP2/POLG2/DDX28/LRRC59/ATAD3A/TRMT10C/HSPA9/TEFM GOBP_NEUTRAL_AMINO_ACID_TRANSPORT 1.900370383 0.000459086 0.009264133 SLC38A5/RGS2/SLC6A6/SLC7A5/SLC6A9/SLC43A2/SLC3A2/SLC38A1/SLC1A5/SLC38A6/SLC38A2/SLC7A8/NFKBIE GOBP_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS 1.825846608 0.002144809 0.027554598 UPP1/ADK/PAICS/UCK2/IMPDH2/HPRT1/PRPS2/PPAT/IMPDH1/GART/AMPD2/ATIC/PRPS1/CMPK1/UCK1 GOBP_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA 1.870943544 0.001180876 0.017693222 RRS1/RPP40/NOP14/FAM207A/DHX37/TSR1/UTP3/HEATR1/DCAF13/KRI1/BYSL/NOL10/UTP20/RRP36/TBL3/NOP9/ABT1 GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING 1.736565696 0.004457288 0.043923004 CXCL8/CCL2/HSPA5/PTPN1/PTPN2/ASNS/DDIT3/ATF4/PPP1R15A GOBP_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 1.734964612 0.004529762 0.04449615 SOD2/HIF1A/MCL1/P4HB/AKT1/GPX1/NONO/NOL3 GOBP_NEGATIVE_REGULATION_OF_DNA_REPLICATION 1.780491278 0.003622786 0.038705301 BCL6/CHEK2/TSPYL2/S100A11/GTPBP4/TIMELESS/SLFN11/FBXO5/GMNN/TTF1/ZNF830/ATG7/BLM/WAPL/LIG3/CDC6 GOCC_SMALL_SUBUNIT_PROCESSOME 1.864526262 0.000714507 0.012194417 NOP14/UTP3/HEATR1/PDCD11/DCAF13/RRP9/NOL10/UTP14A/UTP20/WDR3/IMP4/FBL/FCF1/KRR1/TBL3/NOP58/IMP3/NOC4L/MPHOSPH10/XRCC5/WDR36/NOP56/NOL6/UTP23/PWP2 GOBP_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 1.813468516 0.001657651 0.022803704 TLR2/IRAK2/IRAK4/MYD88/TLR5/HSPD1/IRAK1/IRAK3/TNIP1/CD14/BTK/TAB3/IRF1/UBB/UBC/TLR1 GOBP_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING 1.710462078 0.003770756 0.039605681 RRS1/RPP40/NOP14/NOB1/TSR1/EXOSC8/KRI1/ERI1/UTP20/NHP2/RRP36/TBL3/NOP9/ABT1 GOBP_POSITIVE_REGULATION_OF_P38MAPK_CASCADE 1.70142221 0.004144087 0.041763262 VEGFA/GADD45B/BMP2/GADD45A/MAP3K5/ZC3H12A/SPHK1/GDF6/MFHAS1 GOBP_LACTATION 1.82498401 0.000586889 0.010764819 VEGFA/APLN/HK2/HIF1A/NME1/ZBTB7B GOBP_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION 1.793035397 0.001480844 0.020785302 IL6/IL4R/CLCF1/IL33/MAD2L2/TNFSF13/CD40/SASH3/TFRC/GPI/STX4/XBP1 GOBP_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE 1.926862695 0.000302158 0.006734117 BCL6/IL1RL1/IL4R/IL33/SMAD7/ZBTB7B/HAVCR2/LOXL3/ZC3H12A/NOD2/JAK3/IL20RB/SAMSN1/TRIM27 GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_OXIDATIVE_STRESS 1.831416804 0.000735271 0.012409771 SOD2/HIF1A/CYP1B1/MCL1/MAP3K5/PDK1/MELK/STK24/P4HB/AKT1/GPX1/ZNF622/NONO/PML/GSKIP/PRKCD/NOL3 GOBP_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION 1.772231235 0.00242758 0.029642723 CSTF2T/SNRPF/SLBP/NCBP2/SNRPG/CLP1/MED18/CSTF1/PAPOLA/FIP1L1/SNRPE/CPSF2/ZNF473/PABPN1/SSU72 GOBP_REGULATION_OF_PROTEIN_DEACETYLATION 1.771508773 0.00242758 0.029642723 VEGFA/SPRED3/BCL6/CAMK2D/ZBTB7B/AKAP8/SKI/SPRED1/BRMS1/PRKD1 GOBP_RESPONSE_TO_CADMIUM_ION 1.913119338 0.000255438 0.005882633 MT1X/MT2A/HMOX1/SOD2/MT1M/MT1G/MT1E/MT1A/MT1F/AKR1C3 GOMF_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 1.942061508 0.000105695 0.00330256 SLC38A5/SLC1A3/SLC6A6/SLC7A5/SLC6A9/SLC43A2/SLC3A2/SLC7A11/SLC38A1/SLC22A4/SLC1A5/SLC16A10/SLC7A1/SLC7A7/SLC38A6/SLC38A2/SLC7A8/SLC25A44 GOBP_MATURATION_OF_5_8S_RRNA 1.730623965 0.002824656 0.032405374 RRS1/RPP40/NOP14/WDR12/RPF1/EXOSC8/KRI1/MAK16/ERI1/UTP20/MPHOSPH6/PES1/URB1/NOP9/ABT1/EIF6/EXOSC2/NOL9/NSA2/FTSJ3/RRP15/EXOSC9/PRKDC/EXOSC4/BOP1 GOCC_PRECATALYTIC_SPLICEOSOME 1.907261829 0.000300647 0.006724536 SNRPD1/SF3B5/SNRPF/RNF113A/MAGOHB/SNRPA1/PRPF4/CWC27/SNRPD2/CWC22/EFTUD2/SNRPG/LSM7/LSM4/MFAP1/DHX16/SF3B6/SNRPE/SF3A1/LSM2/SMU1/PRPF31/LSM6/PRPF38B/SF3B4/SF3B3/SF3A3/SNIP1/ZMAT2/SNRPB2/LSM5 GOMF_DISULFIDE_OXIDOREDUCTASE_ACTIVITY 1.739364657 0.003383303 0.036907681 GLRX/ERO1A/PGK1/TXN/PDIA4/CHCHD4/SH3BGRL3/GSTO1/P4HB/PDIA6/GLRX2/ERO1B/TXNDC17/GLRX3 GOBP_PURINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS 1.777541973 0.001496629 0.020865554 ADK/TJP2/PAICS/NT5E/IMPDH2/AK1/HPRT1/PRPS2/PPAT/IMPDH1/AK4/GART/AK2/AMPD2/ATIC GOBP_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION 1.701838901 0.004076951 0.041482998 BCL6/IL4R/ARG2/SMAD7/ZBTB7B/LOXL3/ZC3H12A/JAK3/CBLB/CBFB/CD274 GOBP_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY 2.080501273 3.51E-07 3.41E-05 IL6/IL1R1/IL1RAP/IRAK2/NFKBIA/TNIP2/IRAK4/IL1R2/MYD88/RELA/IRAK1/IRAK3/NOD2/IL1RL2/PSMA6/PSMD11/PSMD12/OTUD4/NFKB1/MAP3K8/PSMB8/PSMB3/PSMD4/PSMC4/TAB3/EGR1/MIR27A/PSMC5/UBB/UBC/PSMA4/PSMB10/PELI1/PSMD5/IL1RN/PSME4/RIPK2/PSMD8/UBE2V1/PSME3/SQSTM1/PSMA3/PSMA1/PELI2/PSMC2/PSMB5/UBA52 GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 1.93812035 4.20E-05 0.001719998 RPF2/NOP16/MRTO4/RRS1/GTPBP4/WDR12/RPF1/NIFK/WDR74/RPLP0/NOC2L/MAK16/NIP7/ZNF622/NLE1/EBNA1BP2/RPL11/BRIX1/NHP2/NOP2/PES1/URB1/DDX28/RSL1D1/RPL35A/TRAF7/RPL7L1/RPL35/PAK1IP1/RPLP0P6/EIF6/RPL26/NPM1/RPL24/NOL9/MRPL1/MDN1/MALSU1 GOBP_PEPTIDYL_PROLINE_MODIFICATION 1.840059158 0.000410786 0.008571358 FKBP5/EGLN3/ERO1A/FKBP11/P4HA1/PPIF/P4HB/FKBP4/FKBP1A/CWC27/FKBP2/PPID/P4HA3/PRDX4/P4HA2/PPIL3/FKBP1B GOBP_RIBONUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS 1.857885746 0.000243818 0.005742644 UPP1/ADK/TJP2/PAICS/NT5E/UCK2/IMPDH2/AK1/HPRT1/PRPS2/PPAT/IMPDH1/AK4/GART/AK2/AMPD2/ATIC/PRPS1 GOBP_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS 1.881911201 0.000404628 0.008499922 ODC1/SLC7A11/PSMA6/PSMD11/SLC7A7/PSMD12/PSMB8/PSMB3/PSMD4/PSMC4/SIRT4/NQO1/PSMC5/PSMA4/PSMB10/PSMD5/PSME4/PSMD8/PSME3/PSMA3/PSMA1/OAZ2/PSMC2/PSMB5/PSMD2/PSME1/PSMC1/PSMD14/PSMD6/PSMB1/PSMB4/PSMA5/PSMB7/PSMC6/CLN3 GOBP_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS 1.970959325 1.45E-05 0.000761867 CDK2/PTTG1/PSMA6/PSMD11/CDK1/PSMD12/PSMB8/AURKA/PSMB3/PSMD4/FBXO5/PSMC4/CDC26/PSMC5/UBB/UBC/AURKB/PSMA4/BUB1B/PSMB10/PSMD5/BUB3/PSME4/PSMD8/PSME3/UBE2D1/UBE2S/MAD2L1/PSMA3/PLK1/PSMA1/PSMC2/PSMB5/UBA52/PSMD2/PSME1/UBE2C/PSMC1/CDC27/PSMD14/PSMD6/CCNB1/CDC20/PSMB1/PSMB4/ANAPC15/ANAPC10/ANAPC4/PSMA5/PSMB7 GOBP_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA 1.931987561 3.88E-05 0.001620176 VEGFA/CA9/EGLN3/HIF1A/PSMA6/PSMD11/PSMD12/PSMB8/PSMB3/PSMD4/VHL/PSMC4/EPAS1/EGR1/ARNT/PSMC5/RBPJ/UBB/UBC/PSMA4/PSMB10/PSMD5/PSME4/PSMD8/HIF3A/PSME3/PSMA3/HIF1AN/PSMA1/BACH1/PSMC2/PSMB5/UBA52 GOMF_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 1.795570048 0.002312585 0.029049802 SLC38A5/SLC1A3/SLC7A5/SLC6A9/SLC43A2/SLC3A2/SLC7A11/SLC38A1/SLC1A5/SLC7A1/SLC7A7/SLC38A6/SLC38A2/SLC7A8 GOBP_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS 1.899966667 0.000150025 0.004202052 TNKS1BP1/CCT2/DKC1/RFC1/GAR1/ACD/NAT10/NOP10/TCP1/SMG6/CCT4/SRC/HSP90AB1/HNRNPC/NHP2/CCT5/WRAP53/GNL3L/AURKB/PTGES3/PKIB/TEP1/TERC/TERF2/HMBOX1/TINF2/HNRNPU/CCT8/PINX1/XRCC5/POT1/DCP2/CCT6A/TNKS GOBP_SNRNA_TRANSCRIPTION 1.917502387 5.47E-05 0.002073576 ELL2/POLR2H/POLR2I/POLR2L/POLR2K/INTS10/TAF11/NABP2/SNAPC1/TAF5/GTF2E2/TAF13/ZNF143/NABP1/POLR2A/INTS5/CCNK/GTF2B/NCBP2/CDK7/MEPCE/TAF6/ELL/SRRT/TAF8/INTS4/INTS8/GTF2A2/POU2F1/GTF2F1/POLR2D/SNAPC2 GOMF_RNA_POLYMERASE_ACTIVITY 1.696521365 0.002574312 0.030547844 POLR2H/POLR2I/POLR2L/POLR2K/POLR1C/POLR3A/RMRP/POLR3C/POLR2A/POLR3D/POLR1B/POLR1D/POLR3E/POLR3B/POLR2D/POLR1A/TRNT1/POLR1E/PRIM1/POLR2J/CRCP/POLR2M/POLR3F/POLR3K/POLR2F/POLR3H/POLR2J2/POLR2B/POLR2C/POLR2G/POLRMT GOBP_AMINO_ACID_TRANSMEMBRANE_TRANSPORT 1.904006232 6.18E-05 0.00228908 SLC38A5/RGS2/SLC1A3/SLC6A6/SLC7A5/PDPN/SLC6A9/SLC43A2/SLC3A2/LRRC8A/SLC7A11/SLC38A1/SLC22A4/SLC1A5/SLC16A10/SLC7A1/SLC7A7/SLC38A6/SLC38A2/SLC7A8 GOBP_MICROGLIAL_CELL_ACTIVATION 1.700718561 0.004686572 0.045604234 TLR2/IL6/C5AR1/IL33/CTSC/LDLR/IFNGR1/TYROBP/NR1D1/SPHK1/FPR2/CLU GOBP_P38MAPK_CASCADE 1.724098201 0.002124714 0.027409686 VEGFA/GADD45B/BMP2/HGF/GADD45A/ZFP36L1/MAP3K5/ZC3H12A/SPHK1/ZFP36/GDF6/MFHAS1 GOBP_MATURATION_OF_SSU_RRNA 1.77114868 0.002271533 0.028649882 RRS1/RPP40/NOP14/FAM207A/NOB1/DHX37/TSR1/SRFBP1/NAT10/UTP3/HEATR1/DCAF13/KRI1/BYSL/NOL10/UTP20/WDR3/RRP36/TBL3/NOL11/NOP9/ABT1 GOMF_TRANSLATION_INITIATION_FACTOR_ACTIVITY 1.769372193 0.00194444 0.025615522 EIF1AY/EIF4A1/EIF2S2/EIF2B2/EIF3J/EIF5/EIF1B/EIF3I/EIF2B4/DHX29/EIF3CL/EIF3B/AGO2/EIF4G1/DENR/EIF2S1/EIF3D/EIF2B1/EIF3A/EIF6/EIF5B/EIF4A2/EIF4G2/EIF2B5/EIF4H/EIF3M/EIF2B3 GOBP_TRANSITION_METAL_ION_HOMEOSTASIS 2.022645211 2.58E-06 0.000190869 MT1X/MT2A/CP/HMOX1/MT1M/MT1G/STEAP1/MT1E/MT1A/MT1F/HIF1A/FTH1/MYC/S100A9/SLC11A1/STEAP3/SLC6A9/SLC39A14/STEAP2/S100A8/SLC39A8/STEAP4/SLC39A4/SLC25A37/TFRC/SLC31A1/BTBD9/ATOX1/FTL/CUTC/EPAS1/MT1DP GOBP_CELL_CYCLE_DNA_REPLICATION 1.827236733 0.00091695 0.014544887 BCL6/RFC2/CDC7/CHEK2/POLE3/FEN1/POLE4/RFC1/POLD2/POLE2/ZPR1/FBXO5/POLD3/GMNN/GINS1/POLD4/DBF4/RAD51/CDC45/MCM2/RFC4/PCNA/TERF2/ZNF830/GINS3/CDT1 GOBP_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS 1.964738583 9.12E-06 0.000504417 MT1X/MT2A/CP/HMOX1/MT1M/MT1G/MT1E/MT1A/MT1F/HIF1A/FTH1/MYC/S100A9/SLC11A1/SLC6A9/SLC39A14/S100A8/SLC39A8/SLC39A4/TFRC/SLC31A1 GOBP_NCRNA_TRANSCRIPTION 1.966921479 5.15E-06 0.000323456 ELL2/POLR2H/POLR2I/POLR2L/POLR2K/INTS10/TAF11/NCL/NABP2/SNAPC1/TAF5/GTF2E2/TAF13/GTF3C6/NIFK/ZNF143/NABP1/POLR2A/SMARCA4/INTS5/CCNK/GTF2B/NCBP2/TCOF1/CDK7/MEPCE/POLR1B/NOL11/IPPK/TAF6/ELL/SRRT/TAF8/INTS4/SMARCB1/INTS8/GTF2A2/POU2F1/GTF2F1/PIH1D1/POLR2D/SNAPC2/TAF1B/POLR1E GOBP_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION 1.763985725 0.000683319 0.011901612 IL6/BCL6/IL4R/CLCF1/IL33/MAD2L2/TNFSF13/IL13RA2/CD40/SASH3/TFRC/GPI/STX4/XBP1 GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS 1.831871204 0.000181185 0.00481457 RRS1/RPP40/NOP14/FAM207A/NOB1/DHX37/TSR1/SRFBP1/NAT10/UTP3/HEATR1/DCAF13/KRI1/BYSL/NOL10/LTV1/RPS27L/UTP20/WDR3/RPS10/RPS17/RRP36/RPSA/TBL3/RPS6/NOL11/RPS25/NOP9/NOM1/ABT1/LSM6/NPM1/HELB/RIOK3/XRCC5 GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS 1.749150376 0.002477687 0.030013701 GLRX/ERO1A/IFI30/PGK1/TXN/PDIA4/CHCHD4/SH3BGRL3/GSTO1/P4HB/SESN2/PDIA6/QSOX2/GLRX2/ERO1B GOBP_TELOMERE_ORGANIZATION 2.035699113 8.65E-08 1.08E-05 MYC/RFC2/POLE3/TNKS1BP1/NABP2/FEN1/POLE4/CCT2/DKC1/GNL3/RFC1/GAR1/ACD/NAT10/TPRKB/POLD2/POLE2/DCLRE1C/NOP10/TCP1/POLD3/SMG6/ERCC1/CCT4/SRC/DOT1L/HSP90AB1/POLD4/RAD51/SP100/HNRNPC/CCNE1/APEX1/NHP2/CCT5/WRAP53/GNL3L/PML/AURKB/PTGES3/CCNE2/XRCC6/PARP3/PKIB/TEP1/RFC4/TERC/PCNA/TERF2/HNRNPA2B1/SMC6/HMBOX1/TINF2/HNRNPU/EXO1/HDAC8/CCT8/BLM/RPA3/DHX36/PINX1/XRCC5/POT1/DCP2/SMG1/HNRNPD/CCT6A/PRIM1/HUS1B/YLPM1/PRIM2/TNKS/SMC5/USP7/DCLRE1B/TFIP11/SMG5 GOBP_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 1.805282047 0.000333893 0.00725926 TNKS1BP1/CCT2/DKC1/RFC1/GAR1/ACD/NAT10/NOP10/TCP1/SMG6/CCT4/SRC/HSP90AB1/RAD51/HNRNPC/NHP2/CCT5/WRAP53/GNL3L/AURKB/PTGES3/PKIB/TERC/TERF2/HNRNPA2B1/HMBOX1/TINF2/HNRNPU/CCT8/DHX36/PINX1/XRCC5/POT1 GOBP_OVARIAN_FOLLICLE_DEVELOPMENT 1.658435548 0.005317689 0.049722392 VEGFA/PTX3/MMP19/MMP14/CEBPB/ICAM1/EIF2B2/INHBA/EIF2B4/PHB/SRC GOBP_RIBOSOME_BIOGENESIS 2.208420025 1.00E-10 3.66E-08 RPF2/NOP16/GLUL/MRTO4/RRS1/MPV17L2/RPP40/DDX21/NOP14/GTPBP4/WDR12/PTEN/AATF/RRP12/NOLC1/TEX10/FAM207A/TFB2M/XRN2/RPF1/PA2G4/NOB1/LYAR/DHX37/ABCE1/NIFK/TSR1/DKC1/RPS2/SRFBP1/WDR74/GAR1/NAT10/DHX29/UTP3/HEATR1/RMRP/RPLP0/RAN/PDCD11/EXOSC8/SHQ1/NOC2L/DCAF13/RRP1B/KRI1/NOP10/BYSL/MAK16/RRP9/NOL10/ERI1/LTV1/UTP14A/RPS27L/UTP20/WDR43/WDR3/RPS10/NIP7/XPO1/ZNF622/RPS17/RPP25/ISG20L2/NLE1/MRM1/EBNA1BP2/IMP4/RPL11/NOL8/FBL/BRIX1/FCF1/NHP2/KRR1/NOP2/MPHOSPH6/PES1/RRP36/MRPS2/RPSA/TBL3/RRP1/URB1/GNL3L/RPS6/NOL11/DIS3/DDX28/RPS25/MYBBP1A/ISG20/DDX27/EXOSC5/RPUSD3/DDX49/NOP58/NOP9/RSL1D1/IMP3/NOC4L/NSUN3/NOM1/WDR75/USP36/ABT1/WBP11/EIF4A3/UTP15/RPL35A/TRAF7/RPL7L1/RPL35/LSM6/PAK1IP1/CUL4B/MPHOSPH10/C1QBP/NSUN4/RPLP0P6/EIF6/RPL26/LSG1/GNL2/NPM1/WDR55/PIH1D1/RPP30/DDX56/HELB/EXOSC2/RIOK3/MRPL36/XRCC5/CUL4A/RPL24/ESF1/NOL9/RNASEL/ZCCHC4 GOBP_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION 1.789871634 0.000350063 0.007531815 CSTF2T/POLR2H/POLR2L/POLR2K/PRMT5/POLR1C/TAF1D/SNRPF/XRN2/SLBP/POLR2A/NCBP2/SNRPG/CLP1/MED18/CSTF1/CDK7/PAPOLA/FIP1L1/POLR1B/TTF1/SNRPE/SMN2/CPSF2/ZNF473/PABPN1/SSU72/POLR1A/SYMPK/TAF1B/POLR1E/DHX9 GOBP_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS 1.6853237 0.003908083 0.040366217 BCL6/CLCF1/MAD2L2/TNFSF13/HSPD1/CD40/TFRC/BATF/ERCC1/XRCC4/RNF168/SUPT6H/PARP3/TGFB1/SLC15A4/EXO1 GOCC_U2_TYPE_SPLICEOSOMAL_COMPLEX 1.85955687 7.78E-05 0.002702575 SNRPD1/BUD31/SF3B5/RBM8A/SNRPF/RNF113A/MAGOHB/SNRPA1/SNRPC/PRPF4/CWC27/U2AF2/CASC3/SNRPD2/CWC22/EFTUD2/SNRPG/LSM7/PRPF40A/SYF2/BCAS2/LSM4/MFAP1/DHX16/SF3B6/SNRPE/SF3A1/EIF4A3/LSM2/SMU1/PRPF31/LSM6/SF3B4/PRPF19/SF3B3/SF3A3/RBM22/SNIP1/ZMAT2/SNRPB2/LSM5/GCFC2 GOBP_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION 1.774421224 0.000577228 0.010650455 TLR2/POLR2H/IFI16/FLOT1/POLR2L/POLR2K/MYD88/POLR1C/HSPD1/RELA/IRAK1/NFKB2/PQBP1/POLR3A/NFKB1/TBK1/MAVS/CD14/POLR3C/MMP12/DHX33/IRF1/POLR3D/XRCC6/RIPK2/POLR3E/POLR3B/HMGB2/ZCCHC3/DHX36/RIOK3/XRCC5/STAT6/DHX9 GOBP_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS 1.721379593 0.002718382 0.031653371 BCL6/CLCF1/SAMHD1/MAD2L2/TNFSF13/HSPD1/CD40/TFRC/BATF/PMS2P1/ERCC1/CTNNBL1/XRCC4/RNF168/SUPT6H/PARP3/TGFB1/SLC15A4/PMS2/EXO1 GOBP_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION 1.688761077 0.003564662 0.038347867 HMOX1/TLR2/IL6/HIF1A/IL1RL1/IL4R/IL33/TSLP/MYD88/HAVCR2/LBP/NOD2/C5/ADAM17 GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS 1.67833148 0.002385269 0.029462598 ERO1A/CASP4/CEBPB/PTPN1/PTPN2/ERN1/MAP3K5/BCL2L1/ITPR1/CREB3L1/DDIT3/ATF4/XBP1/BAK1/PPP1R15A/PML/BAX/TNFRSF10B/TRIB3/BCL2L11/NCK1/TXNDC12/HSPA1A/NCK2/DAB2IP GOBP_HORMONE_BIOSYNTHETIC_PROCESS 1.661095991 0.004930733 0.04746021 ADM/DIO3/DIO2/BMP2/HIF1A/ATP1A1/CYP19A1/NFKB1/H6PD/EGR1/ARNT GOCC_CATALYTIC_STEP_2_SPLICEOSOME 1.830584935 0.000229442 0.005511678 SNRPD1/BUD31/RBM8A/SNRPF/HNRNPF/DDX23/MAGOHB/SNRPA1/CWC27/SNRPD2/CWC22/EFTUD2/HNRNPC/SNRPG/HNRNPA3/PPIL3/LSM7/SYF2/BCAS2/HNRNPR/CACTIN/SF3B6/DHX38/PRPF4B/SNRPE/HNRNPA2B1/SF3A1/EIF4A3/LSM2/HNRNPU/GPATCH1/PRPF19/MAGOH/SF3B3/SRSF1/SF3A3/RBM22/DDX41/HNRNPM/ALYREF/SNRPB2/HNRNPH1 GOCC_CAJAL_BODY 1.785164645 0.000495818 0.009849832 CDK2/SCARNA8/SNORA38/SCARNA1/SCARNA23/EAF1/NOLC1/SCARNA14/DKC1/GAR1/SNRPC/PRPF4/NOP10/ZPR1/TOE1/EFTUD2/XPO1/FBL/NHP2/TRIM22/WRAP53/ISG20/NOP58/ELL/TERC/TGS1/HNRNPA2B1/SMN2/ZNF473/HMBOX1/PRPF31 GOBP_ER_NUCLEUS_SIGNALING_PATHWAY 1.658520771 0.003593179 0.038521358 CXCL8/CCL2/LPCAT3/HSPA5/PTPN1/PTPN2/ZBTB7B/ASNS/DDIT3/ATF4/XBP1/PPP1R15A GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING 1.732216471 0.001311049 0.018959869 THBD/SPP1/SERPINE1/C1QTNF1/PLAUR/UBASH3B/PDGFRA/PDGFA/SIGLEC10/TFPI/RTN4RL1/PTEN/SMAD3/SERPINE2/RGMA GOBP_REGULATION_OF_TELOMERE_MAINTENANCE 1.751677756 0.00069414 0.011989345 MYC/NABP2/CCT2/DKC1/GNL3/ACD/NAT10/TCP1/SMG6/ERCC1/CCT4/SRC/HNRNPC/CCT5/GNL3L/PML/AURKB/PKIB/TERF2/HNRNPA2B1/HMBOX1/TINF2/HNRNPU/HDAC8/CCT8/DHX36/PINX1/XRCC5/POT1/DCP2/SMG1/HNRNPD/CCT6A/YLPM1/TNKS GOBP_ACUTE_INFLAMMATORY_RESPONSE 1.810978711 0.000179591 0.00479269 SERPINA3/SERPINA1/CD163/IL6/TREM1/OSMR/SAA1/PLSCR1/ASS1/SAA2/CEBPB/FN1/APOL2/C2CD4A/B4GALT1/PTGES/S100A8/PTGS2/ICAM1/ORM2/LBP GOMF_MONOSACCHARIDE_BINDING 1.687001812 0.002507659 0.030101586 HK2/EGLN3/PYGL/PLOD2/ENG/SLC2A3/GNPNAT1/P4HA1/HK3/PFKP/GPI/SLC2A5/FUOM/PLOD1/TALDO1/P4HA3/P4HA2/LMAN1 GOBP_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS 1.729176618 0.000589038 0.010772457 SOD2/HIF1A/HGF/CYP1B1/TXN/SLC7A11/MCL1/MAP3K5/PDK1/MELK/STK24/P4HB/MMP3/AKT1/ATF4/GPX1/ZNF622/RIPK1/PDE8A/NONO/PML/SLC1A1/GSKIP/PRKCD/NOL3 GOCC_MITOCHONDRIAL_LARGE_RIBOSOMAL_SUBUNIT 1.679254274 0.004216903 0.042155471 MPV17L2/MRPL52/MRPL57/MRPL32/MRPL12/MRPL27/MRPL41/MRPL4/MRPL30/MRPL21/MRPL3/NSUN3/MRPL54/MRPL34/MRPL2/MRPL28/NSUN4/MRPL16/MRPL15/NDUFAB1/MRPL36/MRPL50/MRPL46/MRPL40/MALSU1/MRPL35/MRPL14/MRPL39/MRPL53/MRPL9/MRPL37/MTERF4/MRPL33 GOBP_PROTEIN_TRANSMEMBRANE_TRANSPORT 1.671524123 0.003027757 0.034044471 ABCA1/HSPA5/HSPA8/GRPEL1/MCL1/CHCHD4/HSPD1/SEC61G/TOMM40/ROMO1/CLU/PEX13/TIMM17A/SEC61A1/PEX5/SEC63/TOMM40L/TIMM44/PEX7/TRAM2/TIMM50/GRPEL2/RTN2/TOMM22 GOBP_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 1.652594432 0.002431294 0.029642723 CCT2/DKC1/ACD/NAT10/TCP1/SMG6/CCT4/SRC/HNRNPC/CCT5/GNL3L/AURKB/PKIB/TERF2/HNRNPA2B1/HMBOX1/TINF2/HNRNPU/CCT8/DHX36/PINX1/XRCC5/POT1/DCP2/CCT6A/TNKS GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS 1.851634196 2.65E-05 0.001219219 VEGFA/HMOX1/CA9/EGLN3/HIF1A/CEBPB/HSPA5/MUC1/BAG3/RELA/SESN2/PSMA6/PSMD11/PSMD12/CREB3L1/DDIT3/SIN3A/PSMB8/PSMB3/PSMD4/VHL/ATF4/PSMC4/EPAS1/EGR1/ARNT/PSMC5/RBPJ/UBB/UBC/PSMA4/PSMB10/PSMD5/PSME4/RPS6KA3/PSMD8/HIF3A/PSME3/PSMA3/HIF1AN/NCK1/RGS14/PSMA1/BACH1/PSMC2/HSPA1A/PSMB5/UBA52/NCK2 GOBP_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH 1.627106867 0.00428176 0.04266664 SOD2/HIF1A/HGF/TXN/SLC7A11/MCL1/P4HB/MMP3/AKT1/ATF4/GPX1/RIPK1/PDE8A/NONO GOBP_RRNA_METABOLIC_PROCESS 2.045923915 2.10E-09 5.21E-07 RPF2/MRTO4/RRS1/RPP40/DDX21/NOP14/GTPBP4/WDR12/RRP12/NOLC1/TEX10/FAM207A/TFB2M/XRN2/RPF1/PA2G4/NOB1/LYAR/DHX37/NIFK/TSR1/DKC1/RPS2/SRFBP1/WDR74/GAR1/NAT10/UTP3/HEATR1/RMRP/PDCD11/EXOSC8/SHQ1/DCAF13/RRP1B/KRI1/NOP10/BYSL/MAK16/RRP9/NOL10/ERI1/UTP14A/UTP20/WDR43/WDR3/RPS17/RPP25/ISG20L2/MRM1/EBNA1BP2/IMP4/RPL11/NOL8/FBL/FCF1/NHP2/KRR1/NOP2/MPHOSPH6/PES1/RRP36/TBL3/RRP1/URB1/RPS6/NOL11/DIS3/RPS25/ISG20/DDX27/EXOSC5/RPUSD3/DDX49/NOP58/NOP9/RSL1D1/IMP3/NOC4L/NSUN3/WDR75/USP36/ABT1/WBP11/EIF4A3/UTP15/RPL35A/RPL7L1/RPL35/LSM6/MPHOSPH10/NSUN4/EIF6/RPL26/WDR55/PIH1D1/RPP30/DDX56/HELB/EXOSC2/RIOK3/ESF1/NOL9/RNASEL/ZCCHC4 GOBP_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE 1.677196855 0.005026218 0.048229976 IL6/BCL6/RELB/BCL3/IL4R/NFKBIZ/STAT3/SMAD7/ZBTB7B/RARA/IL18R1/LOXL3/ZC3H12A/JAK3/BATF/ENTPD7/FCER1G GOBP_RNA_EXPORT_FROM_NUCLEUS 1.90045986 2.73E-06 0.00019761 RRS1/SARNP/RBM8A/NXT1/ABCE1/MAGOHB/UPF2/SEH1L/SLBP/XPOT/NUP188/RAN/EIF5A/U2AF2/CASC3/SMG7/LTV1/SRSF4/SMG6/THOC3/NUP98/XPO1/XPO5/NCBP2/SSB/POM121/DDX39A/NUP58/POM121B/FIP1L1/THOC5/SRSF9/SUPT6H/POM121C/AKAP8L/NOP9/DDX19A/DHX38/HNRNPA2B1/EIF4A3/CPSF2/PABPN1/NUP35/RNPS1/EIF6/LSG1/NPM1/NSUN2/UPF3B/MAGOH/NDC1/POLR2D/NUP62/SRSF1/SYMPK/DHX9/ALKBH5/RBM15B/POLDIP3/SMG1/NUP214/ALYREF/SRSF3/ZC3H11B/NUP155/KHDRBS1/NOL6/RAE1/THOC1/NUP153/IWS1/PHAX/SMG5 GOBP_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION 1.687620404 0.002580495 0.030562894 IL6/BCL6/RELB/BCL3/IL4R/NFKBIZ/CTSL/STAT3/SMAD7/ZBTB7B/RARA/IL18R1/LOXL3/ZC3H12A/SASH3/JAK3/BATF/ENTPD7 GOCC_ORGANELLAR_RIBOSOME 1.751633973 0.000745628 0.01249681 MPV17L2/MRPL52/MRPL57/MRPL32/MRPS28/MRPL12/MRPL27/MRPL41/MRPL4/MRPS17/MRPS5/MRPS2/MRPL30/MRPL21/MRPL3/NSUN3/MRPL54/MRPL34/MRPS12/MRPL2/MRPL28/MRPS10/NSUN4/MRPL16/MRPL15/NDUFAB1/MRPL36/MRPS15/MRPL50/MRPL46/MRPL40/MALSU1/MRPS18B/MRPS18C/MRPS7/MRPL35/MRPL14/MRPS27/MRPL39/MRPS34/MRPS21/MRPL53/MRPS33/MRPL9/MRPL37/MTG2/MTERF4/MRPL33 GOBP_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS 1.661146755 0.003008805 0.033892667 BCL6/CLCF1/SAMHD1/MAD2L2/TNFSF13/HSPD1/CD40/TFRC/BATF/PMS2P1/DCLRE1C/ERCC1/CTNNBL1/XRCC4/RNF168/SUPT6H/PARP3/TGFB1/SLC15A4/PMS2/HMGB2/EXO1 GOBP_MRNA_3_END_PROCESSING 1.785497086 0.000234956 0.005597524 CSTF2T/ZFP36L1/SARNP/RBM8A/LEO1/MAGOHB/SLBP/U2AF2/CASC3/SRSF4/THOC3/NCBP2/CLP1/CSTF1/DDX39A/PAPOLA/FIP1L1/THOC5/SRSF9/NELFE/DHX38/PNPT1/SUPT5H/EIF4A3/CTR9/CPSF2/ZNF473/PABPN1/SSU72/RNPS1/UPF3B/MAGOH/DHX36/POLR2D/SRSF1/SYMPK/RNF20/HSF1/SNRPA/PAF1/POLDIP3/APP/ALYREF/AHCYL1/SRSF3 GOMF_RIBONUCLEOPROTEIN_COMPLEX_BINDING 1.831757642 4.47E-05 0.001803513 YBX3/HSPA5/PIM1/NME1/NEAT1/SNRPD1/PRMT5/WDR12/NOLC1/ZC3H12A/PQBP1/SRP72/ABCE1/PPP1CA/EIF1B/EIF5AL1/DHX29/EIF5A/DERL2/SNRPD2/ERI1/SMG6/SEC61A1/NAA16/CPEB4/ETF1/UHMK1/PRMT3/SRP19/GEMIN5/XPO5/NAA15/DHX33/TACO1/PES1/RPSA/CD2BP2/EIF2S1/EZH2/SRP68/MDM2/EIF4A3/SND1/LETM1/DERL3/PRPF31/HNRNPU/C1QBP/TIMM50/EIF6/NPM1/YTHDF3 GOBP_REGULATION_OF_COAGULATION 1.594992739 0.00481312 0.046544289 THBD/SERPINE1/C1QTNF1/PLAUR/UBASH3B/PDGFRA/PDGFA/TFPI/PROCR GOBP_REGULATION_OF_CHROMOSOME_SEPARATION 1.61798512 0.005220995 0.04921492 PLSCR1/NEK6/PTTG1/MAD2L2/ZWINT/FBXO5/CDK5RAP2/CDC26/DLGAP5/TTK/AURKB/BUB1B/ESPL1/BUB3/CDT1/MAD2L1/CSNK2A1/PLK1/ZW10/CDC6/SPDL1/UBE2C/CDC27/MAD2L1BP/KLHL22/CHFR/CCNB1/CDC20/TACC3/ANAPC15/GEN1/ANAPC4 GOBP_NCRNA_PROCESSING 2.058901272 1.00E-10 3.66E-08 IL6/RPF2/METTL1/MRTO4/STAT3/RRS1/PUS7/RPP40/DDX21/INTS10/NOP14/GTPBP4/WDR12/RRP12/NOLC1/TEX10/FAM207A/WDR4/TFB2M/XRN2/RNF113A/RPF1/POP1/PA2G4/NOB1/LYAR/DHX37/DUS3L/NIFK/TSR1/DKC1/RPS2/SRFBP1/WDR74/GAR1/URM1/NAT10/SMAD3/TRIT1/TPRKB/UTP3/HEATR1/RMRP/PDCD11/EXOSC8/SHQ1/DCAF13/RRP1B/KRI1/ALKBH1/TRMT6/NOP10/BYSL/MAK16/RRP9/NOL10/ERI1/TOE1/AGO2/UTP14A/UTP20/WDR43/WDR3/INTS5/TRPT1/RPS17/RPP25/ISG20L2/MRM1/EBNA1BP2/IMP4/RPL11/CLP1/SSB/NOL8/THG1L/FBL/FCF1/TRMT5/NHP2/ZBTB8OS/KRR1/NOP2/TYW1B/GTPBP3/MPHOSPH6/CTU1/PES1/RRP36/TBL3/RRP1/URB1/RPS6/NOL11/DIS3/THUMPD3/ELAC1/RPS25/ISG20/DDX27/EXOSC5/THADA/RPUSD3/DDX49/NOP58/NOP9/RSL1D1/IMP3/NOC4L/NSUN3/PUS3/WDR75/DTWD1/USP36/ABT1/RPP21/HNRNPA2B1/TRMT13/WBP11/TRMT10C/EIF4A3/SRRT/UTP15/INTS4/PRKRA/RPL35A/INTS8/USB1/RPL7L1/RPL35/DUS4L/LSM6/MPHOSPH10/NSUN4/FTSJ1/EIF6/RPL26/MTFMT/WDR55/NSUN2/PIH1D1/RPP30/DDX56/HELB/EXOSC2/RIOK3/ESF1/NOL9/TRNT1/TRMU/RNASEL/TSEN2/ZCCHC4/TRMT10B GOBP_DETOXIFICATION 1.737575335 0.000299887 0.006724536 MT1X/MT2A/SOD2/MT1M/MT1G/MT1E/ADH4/MT1A/MT1F/S100A9/TXN/ALOX5AP/PIM1/PTGES/PTGS1/PTGS2/GCH1/GSTO1/SESN2 GOBP_RNA_3_END_PROCESSING 1.808074772 5.27E-05 0.002024154 CSTF2T/ZFP36L1/SARNP/RBM8A/LEO1/MAGOHB/DKC1/SLBP/EXOSC8/U2AF2/CASC3/ERI1/TOE1/SRSF4/THOC3/INTS5/NCBP2/CLP1/SSB/FBL/CSTF1/DDX39A/PAPOLA/FIP1L1/THOC5/SRSF9/NELFE/ELAC1/EXOSC5/DHX38/PNPT1/SUPT5H/TRMT10C/EIF4A3/CTR9/CPSF2/ZNF473/PABPN1/INTS8/USB1/SSU72/RNPS1/UPF3B/MAGOH/DHX36/EXOSC2/POLR2D/TRNT1/SRSF1/SYMPK/RNF20/HSF1/SNRPA/PAF1/POLDIP3/APP/SUPV3L1/ALYREF/INTS12/AHCYL1/SRSF3/INTS7/THOC1 GOBP_REGULATION_OF_CHROMOSOME_SEGREGATION 1.660118257 0.002241086 0.028380997 PLSCR1/NEK6/PTTG1/MAD2L2/ZWINT/RCC2/FBXO5/CDK5RAP2/CDC26/DLGAP5/TTK/AURKB/BUB1B/ESPL1/BUB3/SMC6/CDT1/KIF2C/HNRNPU/MAD2L1/MKI67/BECN1/CSNK2A1/PLK1/WAPL/PUM1/ZW10/CDC6/SPDL1/UBE2C/CDC27/SMC5/MAD2L1BP/KLHL22/CHFR/CCNB1/CDC20/TACC3/ANAPC15/GEN1/ANAPC4 GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME 1.664032163 0.003366024 0.036783725 NABP2/CCT2/RCC2/DKC1/GNL3/CDK1/ACD/TCP1/CCT4/XRCC4/CCT5/WRAP53/TTK/GNL3L/AURKB/BUB1B/EZH2/PARP3/BUB3/TERF2/CDT1/TINF2/HDAC8/CCT8/PIH1D1/PLK1/MIS12/WAPL/PINX1/XRCC5/ZW10/POT1/BOD1/TPP1/SPDL1/CHAMP1/CCT6A/TNKS/CDCA5/SMC5 GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 1.666819356 0.001648718 0.02273111 SOD2/SNAI2/PLAUR/HIF1A/YBX3/MIF/PTPN1/ENO1/MUC1/HYOU1/MCL1/BCL2L1/PPIF/CREB3L1/CLU/NOC2L/AKT1/XBP1/SRC/GPX1/CXCL12/URI1/USP47/NONO/TMEM161A/ARHGEF2/BID/MDM2/NOL3/CDKN2D/MMP9/SNAI1/BCL2L2/TXNDC12/MAPK8IP1/IVNS1ABP/HSPA1A GOBP_MRNA_EXPORT_FROM_NUCLEUS 1.742679103 0.00020583 0.005139966 SARNP/RBM8A/NXT1/MAGOHB/UPF2/SEH1L/SLBP/NUP188/EIF5A/U2AF2/CASC3/SMG7/SRSF4/SMG6/THOC3/NUP98/NCBP2/POM121/DDX39A/NUP58/FIP1L1/THOC5/SRSF9/SUPT6H/POM121C/AKAP8L/DDX19A/DHX38/HNRNPA2B1/EIF4A3/CPSF2/PABPN1/NUP35/RNPS1/NSUN2/UPF3B/MAGOH/NDC1/POLR2D/NUP62/SRSF1/SYMPK/ALKBH5/RBM15B/POLDIP3/SMG1/NUP214/ALYREF/SRSF3/ZC3H11B/NUP155/RAE1/THOC1/NUP153/IWS1/SMG5/UPF1/FYTTD1/NUP85/SETD2/CPSF3/GLE1 GOCC_SPLICEOSOMAL_COMPLEX 1.861605302 2.26E-06 0.000171482 HSPA8/SNRPD1/BUD31/SF3B5/NCL/RBM8A/SNRPF/HNRNPF/RNF113A/DDX23/MAGOHB/SNRPA1/SNRPC/PRPF4/RBMXL1/CWC27/U2AF2/CASC3/SNRPD2/PDCD7/CTNNBL1/CWC22/DHX32/EFTUD2/HNRNPC/SNRPG/HNRNPH3/HNRNPA3/PPIL3/LSM7/PRPF40A/PPP1R8/SUGP1/SYF2/BCAS2/LSM4/MFAP1/HNRNPR/SNRNP35/DHX16/CACTIN/SF3B6/DHX38/PRPF4B/ZNF830/SNRPE/HNRNPA2B1/RHEB/WBP11/SF3A1/EIF4A3/LSM2/SNRNP48/SMU1/PRPF31/LSM6/HNRNPU/U2AF1L5/PRPF38B/RBM28/GPATCH1/SF3B4/PRPF19/MAGOH/SF3B3/IVNS1ABP/TRA2B/SRSF1/SF3A3/RBM22/AAR2/SREK1/SNRPA/DDX41/SNIP1/ZCRB1/HNRNPM/ALYREF/ZMAT2/SNRPB2/LSM5/HNRNPH1/GCFC2 GOBP_REGULATION_OF_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT 1.632813693 0.003237103 0.035815492 LIF/IL6/MIR125B1/BCL3/CYP1B1/PTPN2/GADD45A/TSLP/SOCS3/AGT/HGS/JAK3/IFNE/VHL/MIR221/MIR125A/DOT1L GOBP_RNA_LOCALIZATION 1.892528171 6.58E-08 9.75E-06 MVP/RRS1/FLOT1/ZFP36L1/SARNP/RBM8A/NXT1/AHCTF1/KHSRP/ABCE1/CCT2/MAGOHB/DKC1/ZFP36/UPF2/EIF5AL1/SEH1L/SIDT2/SLBP/XPOT/NUP188/RAN/SHQ1/EIF5A/U2AF2/CASC3/NOP10/TCP1/SMG7/LTV1/SRSF4/SMG6/CCT4/THOC3/NUP98/XPO1/XPO5/NCBP2/SSB/FBL/POM121/SNUPN/NHP2/DDX39A/NUP58/POM121B/G3BP2/FIP1L1/CCT5/THOC5/WRAP53/SRSF9/SUPT6H/NOP58/POM121C/AKAP8L/NOP9/DDX19A/DHX38/TERF2/PNPT1/HNRNPA2B1/EIF4A3/CPSF2/TGFBR2/PABPN1/NUP35/HNRNPU/RNPS1/EIF6/LSG1/CCT8/NPM1/NSUN2/UPF3B/PIH1D1/MAGOH/DHX36/NDC1/EXOSC2/POLR2D/NUP62/SRSF1/RUVBL1/SYMPK/HSF1/DHX9/ALKBH5/RBM15B/POLDIP3/DCP2/SMG1/NUP214/CCT6A/ALYREF/BICD1/SRSF3/ZC3H11B/NUP155/TNKS/ZNF385A/KHDRBS1/NOL6/RAE1/THOC1/NUP153/IWS1/PHAX/SMG5 GOBP_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR 1.594471706 0.003957115 0.040602875 RFC2/POLR2H/POLR2I/POLR2L/POLR2K/RFC1/POLD2/POLD3/COPS2/ERCC1/POLR2A/POLD4/HMGN1/CDK7/UBB/UBC/RFC4/PCNA/ZNF830/CUL4B/PRPF19/RPA3/CUL4A/POLR2D/UBA52/LIG3 GOBP_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE 1.60000447 0.004359378 0.043163398 IL6/IL1R1/SLC7A5/LAPTM5/IL4R/CLCF1/IL33/DDX21/MAD2L2/TNFSF13/CD40/IL18R1/BCL10/SASH3/NOD2/FZD5/TFRC/GPI/MAVS/STX4/CLEC7A/XBP1/F2RL1 GOBP_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION 1.622590274 0.002798258 0.032281197 PTTG1/MAD2L2/ZWINT/ACD/NAT10/FBXO5/SMG6/ERCC1/SRC/CDK5RAP2/HNRNPC/TTK/GNL3L/AURKB/BUB1B/ESPL1/MCM2/BUB3/TERF2/CDT1/TINF2/HNRNPU/MAD2L1/PLK1/WAPL/PINX1/ZW10/POT1/TOP2A/DCP2/SPDL1/PHF8/TNKS/MAD2L1BP/KLHL22/CCNB1/CDC20/ANAPC15/GEN1 GOBP_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY 1.762600222 5.32E-05 0.002028466 TLR2/S100A9/TRAF1/IL1RAP/IRAK2/FLOT2/STAT3/FLOT1/RIPK4/S100A8/RPS3/ICAM1/MYD88/CD40/RELA/IRAK1/NFKB2/AGT/IL18R1/MAP3K13/IRAK3/BCL10/NOD2/NLRC4/SPHK1/PSMA6/CIB1/TFRC/NFKB1/CLU/TRADD/DDRGK1/TRIM8/S100A12/TNFRSF11A/BTK/TAB3/HSPA1B/RIPK1/TRIM27/PRKD1/DHX33/ADAM8/TRIM22/UBB/UBC/ITGB2/ARHGEF2/CLOCK/ZBTB7A/RIPK2/PRKCI/UBE2V1/PYCARD/TRIM21/TRIM62 GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 1.901667258 8.32E-08 1.08E-05 HMOX1/DDIT4/SOD2/SNAI2/ERO1A/PLAUR/HIF1A/BCL2A1/S100A9/CDKN1A/YBX3/CASP4/BCL3/CYP1B1/MIF/CEBPB/PTPN1/PTPN2/ENO1/HIPK2/IFI16/CHEK2/FNIP2/MUC1/HYOU1/NKX3-1/MLLT11/ERN1/PLAGL2/S100A8/TNFRSF1A/MCL1/RPS3/MAP3K5/BCL2L1/PPIF/BNIP3/ITPR1/PDK1/MELK/STK24/P4HB/CASP3/CREB3L1/DDIT3/CLU/NUPR1/NOC2L/AEN/AKT1/ATF4/RPS27L/XBP1/SRC/BAK1/GPX1/ZNF622/PPP1R15A/CXCL12/RPL11/URI1/USP47/NONO/UBB/PML/TMEM161A/MYBBP1A/BAX/STYXL1/ARHGEF2/IKBKE/GSKIP/TNFRSF10B/BID/E2F1/SHISA5/MDM2/PRKCD/NOL3/CDKN2D/TRIB3/BCL2L11 GOBP_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS 1.750008057 5.10E-05 0.001977817 CSTF2T/RNASE2/NOCT/RRS1/POLR2I/SAMHD1/RPP40/ERN1/NOP14/REXO2/FEN1/ENDOU/XRN2/POP1/ZC3H12A/NOB1/TSR1/RMRP/EXOSC8/KRI1/CNOT8/ERI1/TOE1/SMG6/AGO2/UTP20/RPP25/ISG20L2/NCBP2/APEX1/NHP2/PPP1R8/FIP1L1/RRP36/TBL3/DIS3/ELAC1/ISG20/EXOSC5/NOP9/ABT1/PNPT1/RPP21/SND1/CPSF2/USB1/EXO1/CNOT1/RPP30/EXOSC2/NOL9/CNOT6/RNASEL/TSEN2/DICER1/PDE12/DCP2/RNASE3/HELZ2 GOBP_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE 1.686858937 0.001283527 0.018823051 CXCL8/CCL2/ERO1A/SHC1/HSPA5/DNAJB9/PTPN1/PTPN2/HYOU1/TSPYL2/ERN1/HDGF/DNAJB11/SRPRB/ASNS/PDIA6/CREB3L1/DDIT3/DDRGK1/ACADVL/DERL2/FICD/ATF4/CANX/XBP1/BAK1/PPP1R15A/CTDSP2/TBL2/DCTN1/EIF2S1/TMTC4/BAX/GSK3A/ZBTB17 GOBP_ALPHA_BETA_T_CELL_DIFFERENTIATION 1.633142511 0.001881854 0.025164233 PNP/IL6/BCL6/RELB/BCL3/TNFSF8/IL4R/NFKBIZ/CTSL/STAT3/SMAD7/ZBTB7B/RARA/IL18R1/LOXL3/ZC3H12A/SASH3/JAK3/BATF/ENTPD7/CBFB/ZBTB16 GOMF_UNFOLDED_PROTEIN_BINDING 1.64905439 0.000989848 0.015418611 HSPA6/HSPA5/CDC37L1/HSPA8/HYOU1/ERN1/GRPEL1/DNAJB11/HSPD1/SRSF12/PFDN2/NUDC/CCT2/TMEM67/CLU/SHQ1/TCP1/HSPA13/CCT4/CANX/ERO1B/HSPA1B/HSP90AB1/CHAF1B/TAPBP/SERPINH1/PFDN5/LMAN1/CCT5/PTGES3/HSPE1/TTC1/DNAJA3/HSPA9/GRPEL2/CCT8/NPM1/HSPA7/HSPA1A/DNAJC4/DNAJA1/MDN1/CCT6A/CALR/PDRG1/PFDN6 GOBP_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER 1.585285477 0.004552903 0.044652919 ELL2/POLR2H/POLR2I/POLR2L/POLR2K/EAF1/LEO1/MLLT1/BRD4/SSRP1/POLR2A/WDR43/CCNK/RNF168/NCBP2/CDK7/NELFE/SUPT6H/EZH2/HEXIM1/ELL/SUPT5H/CTR9/HNRNPU/SUPT16H/GTF2F1/NELFCD/POLR2D/TCERG1/PAF1 GOBP_NUCLEOTIDE_PHOSPHORYLATION 1.681037037 0.0006428 0.011452524 DDIT4/HK2/HIF1A/PGK1/LDHA/GCKR/TPI1/GAPDH/ENO1/NME1/PKM/ALDOC/HK3/PFKP/AK1/SEH1L/GPI/NUP188/NUPR1/ENO2/AK4/PGM1/PFKFB4/NUP98/NME2/PGAM1/TIGAR/ARNT/POM121/NUP58/CMPK1/POM121C/ZBTB7A/PGM2L1/NUP35/BPGM/SLC2A6/EIF6/PRKAA1/PGAM4/HDAC4/PFKL/GALK1/NDC1 GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 1.771412001 1.64E-05 0.000856325 CXCL8/CXCL5/TLR2/CCL2/SERPINE1/CD68/IL6/SBNO2/PPBP/IRAK2/ASS1/CXCL1/CEBPB/NFKBIA/TNIP2/TFPI/CXCL3/TNFAIP3/ICAM1/MYD88/CD40/NR1D1/RELA/PPARD/HAVCR2/IRAK1/LBP/LITAF/ZC3H12A/BCL10/NFKBIB/NOD2/FZD5/AKAP8/ZFP36/HCK/TRIB1/NFKB1/SIRPA/AKT1/CDK19/CXCL6/LYN/CD14/XBP1/SRC GOBP_TYPE_I_INTERFERON_PRODUCTION 1.677414544 0.000711825 0.012194417 TLR2/RELB/POLR2H/TNFAIP3/IFI16/FLOT1/POLR2L/POLR2K/MYD88/POLR1C/HSPD1/RELA/HAVCR2/IRAK1/NFKB2/PQBP1/POLR3A/TRAF3/NFKB1/NMI/SIRPA/TBK1/MAVS/CD14/POLR3C/MMP12/DHX33/IRF1/POLR3D/TRIM56/XRCC6/IKBKE/CACTIN/RIPK2/TRAF3IP1/POLR3E/POLR3B/PYCARD/TRIM21/HMGB2/ZCCHC3 GOMF_HEAT_SHOCK_PROTEIN_BINDING 1.663422719 0.001138832 0.017187515 FKBP5/HSPA6/HIF1A/ARNTL/HSPA5/DNAJB9/CDC37L1/HSPA8/ERN1/RPS3/BAG3/IRAK1/TOMM34/NOD2/FKBP4/ZFP36/DAXX/PPID/FICD/HSPA13/TFAM/BAK1/HSPA1B/HSP90AB1/DNAJC2/LIMK1/HDAC2/FGF1/PTGES3/DNAJC7/BAX/GMEB1/ITGB2/HTT/DNAJC8/DNAJA3/HSPA9/METTL23/STIP1/HDAC8/LMAN2/CSNK2A1/BAG1/HSPA7/HSPA1A/NUP62 GOBP_DNA_DEPENDENT_DNA_REPLICATION 1.72779346 0.000139137 0.003984155 BCL6/RFC2/CDC7/BAZ1A/CHEK2/POLE3/SAMHD1/DDX21/FEN1/HMGA1/DDX23/POLE4/TIMELESS/STOML2/RFC1/POLD2/POLE2/SLFN11/ZPR1/FBXO5/POLD3/GMNN/GINS1/POLD4/DBF4/RAD51/CCNE1/RFWD3/GINS4/POLG2/CDC45/REV3L/CCNE2/MCM10/NOC3L/MCMBP/MCM2/RFC4/ORC1/PCNA/TERF2/ZNF830/GINS3/DNAJA3/CDT1/ATG7/MCM4/BLM/RPA3/HELB/ORC6/ORC5/LIG3/CDC6/WDHD1/POLQ/PRIM1/E2F7/ALYREF/PRIM2/MCM6/GINS2/POLG/THOC1/EME1/BRCA2/UPF1/GEN1/TICRR/MGME1/KAT7/INO80/RFC5 GOBP_NCRNA_METABOLIC_PROCESS 1.954766905 1.00E-10 3.66E-08 IL6/RPF2/METTL1/MRTO4/STAT3/RRS1/PUS7/RPP40/DDX21/RBM7/INTS10/NOP14/GTPBP4/WDR12/RRP12/NOLC1/TEX10/RELA/FAM207A/WDR4/TFB2M/XRN2/RNF113A/RPF1/POP1/PA2G4/ZC3H12A/NOB1/LYAR/DHX37/DUS3L/KHSRP/NIFK/TSR1/DKC1/RPS2/SRFBP1/WDR74/GAR1/URM1/NAT10/SMAD3/TRIT1/TPRKB/UTP3/HEATR1/RMRP/NFKB1/RAN/PDCD11/EXOSC8/SHQ1/DCAF13/RRP1B/KRI1/ALKBH1/TRMT6/NOP10/BYSL/MARS2/MAK16/RRP9/NOL10/ERI1/TOE1/AGO2/UTP14A/UTP20/DARS2/WDR43/WDR3/INTS5/TRPT1/RPS17/AIMP2/RPP25/ISG20L2/XPO5/MRM1/EBNA1BP2/IMP4/RPL11/CLP1/SSB/NOL8/THG1L/FBL/FCF1/TRMT5/NHP2/ZBTB8OS/KRR1/NOP2/TYW1B/GTPBP3/MPHOSPH6/CTU1/PES1/RRP36/MEPCE/TBL3/RRP1/URB1/RPS6/NOL11/DIS3/THUMPD3/ELAC1/RPS25/ISG20/DDX27/EXOSC5/THADA/RPUSD3/DDX49/NOP58/NOP9/RSL1D1/IMP3/NOC4L/NSUN3/PUS3/WDR75/DTWD1/USP36/ABT1/PNPT1/RPP21/HNRNPA2B1/TRMT13/WBP11/TRMT10C/EIF4A3/SRRT/UTP15/INTS4/SND1/PRKRA/PPA1/RPL35A/INTS8/USB1/RPL7L1/RC3H1/RPL35/DUS4L/LSM6/MPHOSPH10/NSUN4/FTSJ1/EIF6/RPL26/MTFMT/WDR55/NSUN2/PIH1D1/RPP30/DDX56/HELB/EXOSC2/RIOK3/FARSA/ESF1/NOL9/TRNT1/TRMU/RNASEL/TSEN2/ZCCHC4/TRMT10B GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN 1.73219138 0.000132238 0.003842323 CXCL8/CCL2/ERO1A/HSPA6/SDF2L1/SHC1/HSPA5/DNAJB9/PTPN1/PTPN2/HSPA8/HYOU1/TSPYL2/ERN1/HDGF/BAG3/DNAJB11/HSPD1/SRPRB/ASNS/PDIA6/CREB3L1/DDIT3/DAXX/DDRGK1/ACADVL/DERL2/FICD/HSPA13/ATF4/CANX/XBP1/BAK1/HSPA1B/PPP1R15A/CTDSP2/TBL2/DCTN1/EIF2S1/TMTC4/AUP1/BAX/GSK3A/ZBTB17 GOBP_ESTABLISHMENT_OF_RNA_LOCALIZATION 1.775525001 9.21E-06 0.000504417 MVP/RRS1/FLOT1/ZFP36L1/SARNP/RBM8A/NXT1/AHCTF1/KHSRP/ABCE1/MAGOHB/ZFP36/UPF2/EIF5AL1/SEH1L/SIDT2/SLBP/XPOT/NUP188/RAN/EIF5A/U2AF2/CASC3/SMG7/LTV1/SRSF4/SMG6/THOC3/NUP98/XPO1/XPO5/NCBP2/SSB/POM121/SNUPN/DDX39A/NUP58/POM121B/G3BP2/FIP1L1/THOC5/SRSF9/SUPT6H/POM121C/AKAP8L/NOP9/DDX19A/DHX38/TERF2/PNPT1/HNRNPA2B1/EIF4A3/CPSF2/TGFBR2/PABPN1/NUP35/HNRNPU/RNPS1/EIF6/LSG1/NPM1/NSUN2/UPF3B/MAGOH/NDC1/POLR2D/NUP62/SRSF1/SYMPK/HSF1/DHX9/ALKBH5/RBM15B/POLDIP3/SMG1/NUP214/ALYREF/SRSF3/ZC3H11B/NUP155/TNKS/KHDRBS1/NOL6/RAE1/THOC1/NUP153/IWS1/PHAX/SMG5 GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE 1.673033708 0.000600713 0.010834889 HMOX1/BCL6/IL1RL1/IL4R/SLAMF8/PTPN2/IL33/TNFAIP3/IFI16/ARG2/SAMHD1/IL13RA2/VSIG4/SMAD7/CD59/ZBTB7B/HAVCR2/LOXL3/IRAK3/ZC3H12A/LYAR/NOD2/COL3A1/JAK3/NMI/LYN/TTLL12/IL20RB/GPX1/SAMSN1/MMP12/TRIM27 GOBP_MRNA_TRANSPORT 1.700607257 0.000139683 0.003984155 MVP/ZFP36L1/SARNP/RBM8A/NXT1/AHCTF1/KHSRP/MAGOHB/ZFP36/UPF2/EIF5AL1/SEH1L/SLBP/NUP188/EIF5A/U2AF2/CASC3/SMG7/SRSF4/SMG6/THOC3/NUP98/XPO1/NCBP2/POM121/DDX39A/NUP58/POM121B/G3BP2/FIP1L1/THOC5/SRSF9/SUPT6H/POM121C/AKAP8L/DDX19A/DHX38/HNRNPA2B1/EIF4A3/CPSF2/PABPN1/NUP35/RNPS1/NSUN2/UPF3B/MAGOH/NDC1/POLR2D/NUP62/SRSF1/SYMPK/HSF1/DHX9/ALKBH5/RBM15B/POLDIP3/SMG1/NUP214/ALYREF/SRSF3/ZC3H11B/NUP155/TNKS/RAE1/THOC1/NUP153/IWS1/SMG5 GOBP_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION 1.623337342 0.000842779 0.013682508 ELL2/POLR2H/POLR2I/POLR2L/POLR2K/EAF1/POLR1C/TAF1D/LEO1/MLLT1/BRD4/SSRP1/POLR2A/WDR43/CCNK/RNF168/NCBP2/HMGN1/CDK7/THOC5/POLR1B/NELFE/SUPT6H/EZH2/HEXIM1/ELL/SUPT5H/CTR9/SETD5/HNRNPU/SUPT16H/TEFM/GTF2F1/NELFCD/POLR2D/POLR1A/TAF1B/POLR1E/TCERG1/PAF1/ALYREF/ADRM1/CDK12/ZNF326/THOC1/IWS1/POLR2J/RTF1 GOMF_GROWTH_FACTOR_RECEPTOR_BINDING 1.641328537 0.002900485 0.032910976 VEGFA/ITGA5/ESM1/ITGB3/IL6/PDGFRA/IL1R1/PLSCR1/IL1RAP/SHC1/PDGFA/PGF/IRAK4/TSLP/ERN1/MYD88/TLR5/PTEN GOBP_ERYTHROCYTE_HOMEOSTASIS 1.632955511 0.001046973 0.015995283 VEGFA/HMOX1/BCL6/HIF1A/MAFB/PTPN2/HIPK2/ACVR1B/STAT3/ZFP36L1/LYAR/INHBA/ZFP36/JAK3/CASP3/L3MBTL3/ANKRD54/MIR222/MIR221/LYN/HCLS1/MFHAS1/EPAS1/HSPA1B/RPS17/FLVCR1/ARNT/SLC11A2/RPS6/PTBP3/ZBTB7A/AXL/KMT2E/HSPA9/HMGB2/KIT/DYRK3/BPGM/JMJD6/TMOD3 GOBP_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 1.682341726 0.000268517 0.006138372 SOD2/SNAI2/PLAUR/HIF1A/S100A9/YBX3/MIF/PTPN1/PTPN2/ENO1/MUC1/HYOU1/NKX3-1/PLAGL2/S100A8/MCL1/RPS3/BCL2L1/PPIF/P4HB/CREB3L1/DDIT3/CLU/NUPR1/NOC2L/AKT1/XBP1/SRC/GPX1/CXCL12/RPL11/URI1/USP47/NONO/UBB/TMEM161A/BAX/STYXL1/ARHGEF2/BID/MDM2/NOL3/CDKN2D/BCL2L11/PRKRA/PYCARD/MMP9/MIR27B/RPL26/SNAI1/BCL2L2/NCK1/BECN1/TXNDC12/MAPK8IP1/IVNS1ABP/HSPA1A/NCK2/ARMC10 GOBP_MYELOID_CELL_HOMEOSTASIS 1.662917762 0.000656434 0.011607095 VEGFA/HMOX1/IL6/BCL6/HIF1A/MAFB/PTPN2/HIPK2/ACVR1B/STAT3/ZFP36L1/SLC7A11/LYAR/INHBA/ZFP36/ADAM17/JAK3/CASP3/L3MBTL3/ANKRD54/MIR222/MIR221/LYN/HCLS1/MFHAS1/EPAS1/BAK1/HSPA1B/RPS17/FLVCR1/ARNT/SLC11A2/RPS6/PTBP3/BAX/ZBTB7A/AXL/KMT2E/BCL2L11/SLC15A4/HSPA9/HMGB2/KIT/DYRK3/BPGM/JMJD6/TMOD3 GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION 1.590477522 0.002640638 0.031034012 CDKN1A/CHMP4C/CLSPN/NABP2/PSMA6/PSMD11/CDK1/PSMD12/NABP1/PSMB8/AURKA/PSMB3/PSMD4/PSMC4/BRCC3/PSMC5/SYF2/USP47/AURKB/PSMA4/PSMB10/PSMD5/FOXO4/PSME4/ORC1/ZNF830/PSMD8/BRSK1/PSME3/PSMA3/PLK1/PSMA1/BLM/VPS4A/PINX1/PSMC2/PSMB5/HMGA2/NAE1/CDC6/PSMD2/PSME1/PSMC1/HUS1B/PSMD14/PSMD6/GPR132/PSMB1/PSMB4/TICRR/PSMA5/CUL1/PSMB7 GOCC_CHROMOSOME_TELOMERIC_REGION 1.647073501 0.001923558 0.025448268 CHEK2/NABP2/FEN1/PPP1CA/CDK1/GAR1/ACD/NAT10/NABP1/LRIF1/SMG6/ERCC1/THOC3/DOT1L/RAD51AP1/RAD51/SP100/TOX4/SSB/APEX1/NHP2/THOC5/MEN1/WRAP53/PML/PTGES3/XRCC6/EZH2/MCM2/TEP1/TERC/ORC1/PCNA/TERF2/HNRNPA2B1/SMC6/HMBOX1/TINF2/MCM4/BLM/DHX36/PINX1/CBX3/NSMCE1/XRCC5/POT1/ORC5/EID3/PPP1CC/ALYREF/TNKS/MCM6/SMC5/THOC1/HAT1/DCLRE1B/TFIP11/CBX5 GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE 1.587356574 0.003261849 0.035961303 HMOX1/DDIT4/SNAI2/BCL2A1/CDKN1A/BCL3/MIF/HIPK2/IFI16/CHEK2/FNIP2/MUC1/TNFRSF1A/MCL1/RPS3/BCL2L1/CLU/NUPR1/AEN/RPS27L/BAK1/CXCL12/USP47/PML/TMEM161A/BAX/IKBKE/BID/E2F1/SHISA5/CDKN2D/BCL2L11 GOBP_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 1.667455977 0.000394401 0.008313168 TLR2/BIRC3/S100A9/IRAK2/NFKBIA/TNIP2/CTSL/TNFAIP3/FLOT1/IRAK4/S100A8/MYD88/TLR5/CTSB/FADD/HSPD1/CD40/NR1D1/HAVCR2/IRAK1/LBP/MAPKAPK3/IRAK3/BCL10/NOD2/PIK3AP1/TNIP1/TRAF3/OTUD4/NMI/TBK1/LYN/MFHAS1/CD14/BTK/TAB3/F2RL1/BIRC2/RIPK1/UBE2D3/IRF1/UBB/UBC/PELI1/ITGB2/IKBKE/CACTIN/RPS6KA3/TLR1/RIPK2/APPL1/SLC15A4/SCIMP GOBP_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR 1.583623401 0.00214399 0.027554598 SPRED3/SNAI2/SOX4/CDKN1A/NDRG1/BCL3/CDK2/MIF/HIPK2/CHEK2/MUC1/GADD45A/TNKS1BP1/SESN2/CDK1/BATF/AURKA/USP10/CNOT8/SPRED1/RPS27L/SP100/CNOT11/PML/BAX/CNOT10/E2F1/MDM2/PCNA/GTSE1/CARM1/E2F4/DYRK3/RPL26/CNOT1/SNAI1/CASP2 GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS 1.727225132 2.39E-05 0.001124089 YBX3/SLC11A1/ZFP36L2/HSPA8/NOCT/TNFSF13/ZFP36L1/AXIN2/MYD88/ZC3H12A/KHSRP/PSMA6/PSMD11/ZFP36/PSMD12/SET/EXOSC8/PSMB8/PSMB3/AKT1/PSMD4/CNOT8/PLEKHN1/PABPC4/AGO2/EIF4G1/PSMC4/XPO1/FASTKD1/HNRNPC/APEX1/PSMC5/GIGYF2/ZC3HAV1/UBB/DIS3/UBC/FUS/PSMA4/PSMB10/HNRNPR/PSMD5/EXOSC5/SERBP1/E2F1/PSME4/PRKCD/PNPT1/PSMD8/PSME3/RC3H1/HNRNPU/TBRG4/CNOT1/PSMA3/NPM1/YTHDF3/PSMA1/DHX36/DHX34/PUM1/EXOSC2/PSMC2/HSPA1A/PSMB5/UBA52/RNASEL/ANP32A/TAF15/DHX9/ALKBH5/FXR2/DCP1A/PSMD2/PDE12/THRAP3/DCP2/METTL16/PSME1/NUP214/HNRNPD/HNRNPM/PSMC1 GOBP_MITOCHONDRIAL_GENE_EXPRESSION 1.679444562 0.000158829 0.004389335 SHMT2/MPV17L2/TFB2M/MRPL52/TRIT1/MRPL57/MRPL32/ALKBH1/MRPS28/DARS2/TFAM/MRPL12/MRPL27/MRPL41/MRPL4/TRMT5/TACO1/MRPS17/MRPS5/MRPS2/MRPL30/MRPL21/RPUSD3/MRPL3/NSUN3/MRPL54/MRPL34/PNPT1/MRPS12/TRMT10C/MRPL2/MRPL28/NOA1/GADD45GIP1/MRPS10/C1QBP/TEFM/TBRG4/PRKAA1/MRPL16/MRPL15/MRPS25/MRPL36/TRNT1/MRPS15/TRMT10B/MRPL50/MRPL46/MRPL1/MRPL40/EARS2/MALSU1/SUPV3L1/MRPS18B/YARS2/MRPS18C/MRPS7/MRPL35/MRPL14/MRPS27/WARS2/MRPL39/MRPS34/MRPS21/MRPL53/MRPS33/TRUB2/MRPL9/MRPL37/MTG2/MTERF4/TSFM/MRPL33/MTERF1/GATB/MRPL49/FOXO3 GOBP_INTERFERON_GAMMA_PRODUCTION 1.559324446 0.00494571 0.047530791 IL1R1/IL1RL1/SLC11A1/BCL3/SLC7A5/LAPTM5/IL33/FADD/HSPD1/RARA/HAVCR2/IL18R1/ZC3H12A/SASH3/PDE4D/NOD2/INHBA/FZD5/DDIT3/SIRPA/CD14/CLEC7A/F2RL1/IL20RB/CD274 GOMF_CYTOKINE_RECEPTOR_BINDING 1.72959296 3.40E-05 0.00149268 CXCL8/VEGFA/CXCL5/CCL2/ITGA5/CCL20/ITGB3/LIF/IL6/OSMR/CCL7/TRAF1/PPBP/IL1RAP/CXCL1/ENG/MIF/SHC1/TNFSF8/CLCF1/CXCL3/IL33/PGF/IRAK4/TSLP/TNFSF13/SMAD7/MYD88/TLR5/MSMP/FADD/CNIH4/C5/CSF1/ADAM17/TRAF3/FKBP1A/CASP3/SMAD3/CKLF/TRADD/IFNE/CXCL6/CXCL16/EFNA5/SPRED1/TRAF4/CCL18/CRLF1/CXCL12/RIPK1/IL6ST/IL13RA1 GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS 1.726426002 5.05E-05 0.001976002 CXCL8/CXCL5/TLR2/CCL2/SERPINE1/CD68/IL6/SBNO2/PPBP/IRAK2/ASS1/CXCL1/CEBPB/NFKBIA/HSPA5/TNIP2/TFPI/CXCL3/TNFAIP3/ICAM1/MYD88/CD40/NR1D1/RELA/PPARD/HAVCR2/IRAK1/LBP/LITAF/ZC3H12A/BCL10/NFKBIB/NOD2/FZD5/AKAP8/ZFP36/HCK/TRIB1/DDIT3/NFKB1/SIRPA/TXNIP/AKT1/CDK19/CXCL6/LYN/CD14/CLEC7A/XBP1/SRC/BTK/CD274 GOMF_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING 1.551948192 0.005252414 0.04933461 SHMT2/EIF1AY/EIF4A1/EIF2S2/EIF2B2/ABCF1/EIF3J/EIF5/EIF1B/EIF3I/EIF5AL1/EIF2B4/DHX29/EIF3CL/EIF5A/EIF3B/AGO2/EIF4G1/RPS27L/CPEB4/ETF1/DENR/GTPBP2/TYMS/EIF2S1/EIF3D/EIF2B1/GSPT2/C1QBP/EIF3A/EIF6/EIF5B GOBP_MITOCHONDRIAL_TRANSLATION 1.615661544 0.001300091 0.018936871 SHMT2/MPV17L2/MRPL52/MRPL57/MRPL32/ALKBH1/MRPS28/DARS2/MRPL12/MRPL27/MRPL41/MRPL4/TACO1/MRPS17/MRPS5/MRPS2/MRPL30/MRPL21/RPUSD3/MRPL3/NSUN3/MRPL54/MRPL34/MRPS12/TRMT10C/MRPL2/MRPL28/NOA1/GADD45GIP1/MRPS10/C1QBP/MRPL16/MRPL15/MRPS25/MRPL36/MRPS15/MRPL50/MRPL46/MRPL1/MRPL40/EARS2/MALSU1/MRPS18B/YARS2/MRPS18C/MRPS7/MRPL35/MRPL14/MRPS27/WARS2/MRPL39/MRPS34/MRPS21/MRPL53/MRPS33/TRUB2/MRPL9/MRPL37/MTG2/TSFM/MRPL33 GOBP_REGULATION_OF_CHROMOSOME_ORGANIZATION 1.767574503 4.14E-06 0.000268074 VEGFA/LIF/BCL6/MYC/NEK6/MUC1/PTTG1/MAD2L2/AXIN2/ZBTB7B/NABP2/FEN1/ZWINT/CCT2/AKAP8/DKC1/GNL3/ACD/NAT10/SIN3A/BRD4/AUTS2/TCP1/FBXO5/RNF4/SMG6/ERCC1/CCT4/SRC/CDK5RAP2/HNRNPC/PRKD1/CDC26/DLGAP5/PAXBP1/CCT5/TTK/GNL3L/PML/AURKB/NELFE/BUB1B/ESPL1/AKAP8L/PKIB/MCM2/BUB3/TERF2/KMT2E/HNRNPA2B1/CTR9/SMARCB1/CDT1/HMBOX1/TINF2/HNRNPU/HDAC8/MAD2L1/CCT8/BECN1/MCPH1/PIH1D1/PLK1/DHX36/WAPL/PINX1/XRCC5/ZW10/POT1/RNF20/TOP2A/CDC6/UBE2N/PAF1/DCP2/SMG1/SPDL1/HNRNPD/CCT6A/PHF8/DNMT1/UBE2C/YLPM1/TNKS/CDCA5/CDC27/SMC5/MAD2L1BP/MPHOSPH8/USP7/KLHL22/CHFR/CCNB1/WBP2/SMG5/CDC20/RTF1/TACC3/ANAPC15/SLF1/UPF1/GEN1/ANAPC4/TADA2B GOBP_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE 1.586499163 0.005273762 0.049460411 HMOX1/IL6/BCL6/IL1R1/SLC7A5/LAPTM5/IL4R/CLCF1/IL33/DDX21/MAD2L2/TNFSF13/IL13RA2/SMAD7/CD40/IL18R1/IRAK3/BCL10/SASH3/NOD2/FZD5/JAK3/TFRC/GPI/MAVS/STX4/CLEC7A/XBP1/BTK/F2RL1 GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 1.862632018 9.90E-10 2.93E-07 RPF2/NOP16/GLUL/MRTO4/RRS1/MPV17L2/RPP40/DDX21/SNRPD1/PRMT5/NOP14/EIF2S2/GTPBP4/WDR12/PTEN/AATF/RRP12/NOLC1/TEX10/SNRPF/FAM207A/TFB2M/XRN2/DDX23/NUFIP1/RPF1/SRSF12/PA2G4/NOB1/LYAR/EIF3J/DHX37/ABCE1/NIFK/TSR1/DKC1/RPS2/EIF5/EIF3I/SRFBP1/WDR74/GAR1/NAT10/DHX29/SNRPC/UTP3/EIF3CL/STRAP/RNVU1-1/HEATR1/RMRP/RPLP0/RAN/PDCD11/EXOSC8/SHQ1/NOC2L/DCAF13/RRP1B/KRI1/NOP10/SNRPD2/BYSL/MAK16/EIF3B/RRP9/NOL10/ERI1/LTV1/AGO2/UTP14A/RPS27L/UTP20/WDR43/WDR3/RPS10/NIP7/HSP90AB1/XPO1/DENR/ZNF622/RPS17/RPP25/ISG20L2/GEMIN5/SRPK1/NLE1/MRM1/EBNA1BP2/IMP4/SNRPG/RPL11/CLP1/NOL8/FBL/BRIX1/SNUPN/FCF1/GEMIN6/NHP2/KRR1/RPL13A/NOP2/MPHOSPH6/PES1/RRP36/MRPS2/RPSA/TBL3/RRP1/CD2BP2/URB1/GNL3L/RPS6/NOL11/DIS3/DDX28/LSM4/EIF3D/SRSF9/PTGES3/RPS25/MYBBP1A/ISG20/DDX27/EXOSC5/RPUSD3/DDX49/NOP58/NOP9/RSL1D1/IMP3/DDX20/NOC4L/NSUN3/NOM1/WDR75/USP36/ABT1/NOL3/TGS1/SNRPE/SMN2/WBP11/SF3A1/EIF4A3/UTP15/RNVU1-7/LSM2/RPL35A/TRAF7/RPL7L1/PRPF31/RPL35/LSM6/PAK1IP1/CUL4B/MPHOSPH10/C1QBP/NSUN4/RPLP0P6/EIF3A/EIF6/RPL26/LSG1/GNL2/NPM1/WDR55/PRPF19/PIH1D1/RPP30/DDX56/HELB/EXOSC2/RIOK3/MRPL36/XRCC5/CUL4A/POLR2D/RPL24/ESF1/NOL9/CLNS1A/SRSF1/SF3A3/RNASEL/RUVBL1 GOBP_PYRUVATE_METABOLIC_PROCESS 1.605459997 0.001351577 0.019353934 DDIT4/HK2/HIF1A/PGK1/LDHA/GCKR/TPI1/GAPDH/PDK4/ENO1/PKM/ALDOC/HK3/PDK1/VDAC1/PFKP/SEH1L/ME2/GPI/NUP188/NUPR1/ENO2/PGM1/PFKFB4/NUP98/SLC16A1/PGAM1/TIGAR/ARNT/PCK2/POM121/NUP58/PDP2/POM121C/ZBTB7A/SDS/PGM2L1/NUP35/BPGM/SLC2A6/EIF6/PRKAA1/PGAM4/HDAC4/PFKL/GALK1/SLC16A3/NDC1 GOBP_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS 1.614544846 0.000574862 0.010650455 DDIT4/HK2/HIF1A/PGK1/LDHA/GCKR/TPI1/GAPDH/ENO1/NME1/TJP2/PKM/ALDOC/HK3/NUDT5/PFKP/AK1/SEH1L/GPI/NUP188/NUPR1/ENTPD7/ENO2/AK4/AK2/PGM1/PFKFB4/NUP98/NME2/PGAM1/TIGAR/ARNT/POM121/NUP58 GOBP_RNA_CATABOLIC_PROCESS 1.8122088 2.06E-08 3.77E-06 RPS4Y1/YBX3/SLC11A1/RNASE2/ZFP36L2/HSPA8/MRTO4/NOCT/TNKS1BP1/ERN1/RBM7/TNFSF13/ZFP36L1/RPS3/AXIN2/MYD88/RBM8A/FEN1/XRN2/POP1/ZC3H12A/RPL28/KHSRP/PSMA6/PSMD11/MAGOHB/DKC1/ZFP36/RPS2/UPF2/RPL12/PSMD12/PATL1/SIDT2/RPLP0/SET/EXOSC8/PSMB8/SLIRP/PSMB3/AKT1/PSMD4/RPL39/CASC3/ZPR1/CNOT8/SMG9/SMG7/PLEKHN1/SMG6/PABPC4/AGO2/EIF4G1/PSMC4/RPS10/RPL23/HSPA1B/ETF1/XPO1/FASTKD1/RPS17/NCBP2/HNRNPC/NT5C3B/RPL11/RPS18/SSB/APEX1/RPL36A/LSM7/PPP1R8/RPL13A/PSMC5/GIGYF2/ZC3HAV1/RPS20/RPSA/RPS6/CNOT11/UBB/DIS3/UBC/LSM4/RPS25/FUS/PSMA4/ISG20/PSMB10/HNRNPR/PSMD5/EXOSC5/DDX49/SERBP1/CNOT10/E2F1/PSME4/ZCCHC17/PRKCD/PNPT1/PSMD8/EIF4A3/SND1/GSPT2/LSM2/RPL35A/SMG8/PSME3/RPS26/RC3H1/RPL35/RPL18A/LSM6/HNRNPU/SKIV2L/RNPS1/RPL26/TBRG4/CNOT1/PSMA3/NPM1/NSUN2/YTHDF3/UPF3B/PSMA1/MAGOH/DHX36/DHX34/PUM1/EXOSC2/PSMC2/HSPA1A/PSMB5/POLR2D/RPL24/CNOT6/UBA52/RNASEL/ANP32A/TAF15/RPS11/DHX9/ALKBH5/FXR2/DCP1A/ZHX2/PSMD2/RPS12/PDE12/THRAP3/SUPV3L1/DCP2/SMG1/METTL16/PSME1/NUP214/HNRNPD/RNASE3/HELZ2/HNRNPM/PSMC1 GOCC_ENDOPLASMIC_RETICULUM_PROTEIN_CONTAINING_COMPLEX 1.556072703 0.003781283 0.039649273 SDF2L1/HSPA5/HYOU1/ERN1/ELOVL6/MAP3K5/SEC61G/SRPRB/ORMDL2/P4HB/TMEM258/PDIA6/FKBP1A/DERL2/PIGH/SEC61A1/EMC2/TAPBP/SEC63/GANAB/PIGY/AUP1/PIGA/DAD1/HM13/DERL3/UBXN7/SSR4/SEL1L/KRTCAP2/OST4/SPCS2/MMGT1/UBXN1/EMC6/EMC9/PIGM/ZW10/RPN2/OSTC/PDIA3/TAP1/PIGS/CALR/SRP9/EMC1/DDOST/RPN1/DPM2 GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT 1.562182457 0.00352328 0.037996082 SLC38A5/SLC2A1/RGS2/SLC1A3/SLC6A6/SLC7A5/PDPN/MID1IP1/SLC6A9/SLC43A2/SLC3A2/AQP9/LRRC8A/SLC7A11/SLC38A1/SLC22A4/SLC1A5/SLC16A10/SLC7A1/SLC7A7/SLC38A6/SLC38A2/SLC7A8/AKT1/PRAF2/SLC5A6 GOBP_RESPONSE_TO_INTERLEUKIN_1 1.655778434 0.000147338 0.004164302 CXCL8/CCL2/CCL20/IL6/HIF1A/IL1R1/CCL7/IL1RAP/IRAK2/CEBPB/NFKBIA/TNIP2/HAS2/TFPI/NKX3-1/IRAK4/IL1R2/ICAM1/MYD88/CD40/NR1D1/RELA/IRAK1/IRAK3/ZC3H12A/NOD2/IL1RL2/MAPK13/PSMA6/PSMD11/PSMD12/OTUD4/NFKB1/MAP3K8/SIRPA/PSMB8/USP10/PSMB3/PSMD4/TNFRSF11A/AKAP12/GBP2/PSMC4/SRC/TAB3/CCL18/MTHFR/RORA/EGR1/HYAL3/MIR27A/PSMC5/UBB/UBC/PSMA4/PSMB10/PELI1/PSMD5/IL1RN/CACTIN/PSME4/RIPK2/CD38/PSMD8/PRKCI/UBE2V1/PSME3/PYCARD/RC3H1/GBP3/SQSTM1 GOBP_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS 1.590308312 0.001444151 0.020454969 IL6/SOX4/ITGA2/YBX3/BCL3/PKM/LARP6/MPV17L2/IFNGR1/TNFRSF1A/RELA/SMPD2/PRR16/NOD2/EIF5AL1/CASP3/NAT10/DHX29/CLU/EIF5A/KRT17/AGO2/EIF4G1/RPS27L/UHMK1/PPP1R15A/LARP4/EIF3D/PLXNB2/RPUSD3/GSK3A/PRKCD/TRMT10C/EIF4A3/CDC123/CNBP/C1QBP/EIF6/RPL26/NSMAF/NCK1/NPM1/YTHDF3/UPF3B/DHX36/PTAFR/POLR2D/NCK2/ZCCHC4/DHX9/FXR2/POLDIP3/EIF4G2/PICALM/DNAJC3/HNRNPD GOBP_NEGATIVE_REGULATION_OF_CELL_ACTIVATION 1.629426653 0.000280162 0.00635784 THBD/HMOX1/C1QTNF1/BCL6/UBASH3B/PDGFRA/CEBPB/LAPTM5/IL4R/PDGFA/EMILIN1/PTPN2/TNFAIP3/ARG2/LDLR/IL13RA2/SDC4/VSIG4/SMAD7/ZBTB7B/FGR/TYROBP/NR1D1/HAVCR2/LOXL3/ZC3H12A/TNFAIP8L2/INHBA/JAK3/CASP3/CBLB/SERPINE2/LRRC32/MILR1/LYN/MIR125A/CBFB/BTK/IL20RB/CD274/SAMSN1/GLMN/DLG5/MIR27A/IRF1 GOBP_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE 1.55142054 0.005187967 0.049174972 SPRED3/SNAI2/SOX4/CDKN1A/NDRG1/BCL3/CDK2/MIF/HIPK2/CHEK2/MUC1/GADD45A/TNKS1BP1/MAD2L2/SESN2/CDK1/BATF/AURKA/USP10/CNOT8/SPRED1/RPS27L/SP100/BRCC3/CNOT11/PML/BAX/CNOT10/BID/E2F1/MDM2/PCNA/GTSE1/CARM1/E2F4/DYRK3/RPL26/CNOT1/SNAI1/CASP2/PRPF19/PLK1 GOBP_REGULATION_OF_MRNA_METABOLIC_PROCESS 1.735382034 2.23E-06 0.000170833 YBX3/SLC11A1/ZFP36L2/HSPA8/NOCT/RBM7/TNFSF13/ZFP36L1/AXIN2/MYD88/NCL/RBM8A/DAZAP1/LEO1/KHDRBS3/SRSF12/ZC3H12A/WTAP/KHSRP/PSMA6/PSMD11/ZFP36/PSMD12/RBMXL1/SET/EXOSC8/PSMB8/PSMB3/AKT1/PSMD4/PRDX6/U2AF2/CNOT8/PLEKHN1/SRSF4/PABPC4/AGO2/EIF4G1/PSMC4/CWC22/NUP98/XPO1/FASTKD1/RBM42/SRPK1/NCBP2/HNRNPC/APEX1/PSMC5/GIGYF2/NSRP1/ZC3HAV1/PAPOLA/PTBP1/UBB/DIS3/UBC/SRSF9/NELFE/FUS/PSMA4/SUPT6H/PSMB10/HNRNPR/PSMD5/EXOSC5/SERBP1/E2F1/PSME4/ZBTB7A/PRKCD/PNPT1/PSMD8/HNRNPA2B1/SUPT5H/SAFB2/CTR9/PABPN1/PSME3/SMU1/RC3H1/HNRNPU/RNPS1/C1QBP/JMJD6/TBRG4/CNOT1/PSMA3/NPM1/YTHDF3/SF3B4/PRPF19/PSMA1/MAGOH/DHX36/DHX34/PUM1/EXOSC2/PSMC2/HSPA1A/PSMB5/TRA2B/UBA52/RNASEL/ANP32A/TAF15/RNF20/HSF1/DHX9/ALKBH5/FXR2/RBM4/DCP1A/SNRPA/PAF1/RBM15B/PSMD2/PDE12/THRAP3/DCP2/METTL16/PSME1/NUP214/HNRNPD/ZC3H10/HNRNPM/PSMC1/SLTM/AHCYL1/SRSF3/SECISBP2/SFSWAP/PSMD14/KHDRBS1/BAG4/EXOSC1/DYRK1A/IWS1/PSMD6/ZC3H12D/CCNB1/SYNCRIP/SAFB/STH/PSMB1/PSMB4 GOBP_TRANSLATIONAL_INITIATION 1.621893772 0.000257689 0.005912582 RPS4Y1/EIF4EBP1/EIF1AY/EIF4A1/RPS3/EIF2S2/EIF2B2/EIF3J/RPL28/ABCE1/PPP1CA/RPS2/EIF5/EIF1B/EIF3I/EIF2B4/RPL12/DHX29/EIF3CL/RPLP0/KLHL25/RPL39/ALKBH1/EIF3B/ATF4/AGO2/EIF4G1/RPS10/RPL23/UHMK1/DENR/RPS17/PPP1R15A/NCBP2/RPL11/RPS18/DHX33/RPL36A/RPL13A/RPS20/RPSA/EIF2S1/RPS6/EIF3D/RPS25/EIF2B1/EIF4EBP3/RPL35A/RPS26/RPL35/RPL18A/CDC123/EIF3A/EIF6/RPL26/EIF5B/NCK1/NPM1/MTFMT/YTHDF3/POLR2D/RPL24/UBA52/NCK2/RPS11/RBM4/EIF4A2/RPS12/EIF4G2/DNAJC3 GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA 1.734604743 9.31E-07 8.51E-05 DDX3Y/RNASE2/METTL1/POLR2H/NOCT/EIF4A1/POLR2I/SAMHD1/RPP40/POLR2L/DDX21/ERN1/POLR2K/POLR1C/REXO2/FEN1/ENDOU/WDR4/TFB2M/XRN2/DDX23/POP1/ZC3H12A/NOB1/DHX37/DUS3L/PTRH2/POLR3A/DHX29/TRIT1/RMRP/ALKBH1/TRMT6/CNOT8/MARS2/ERI1/TOE1/SMG6/POLR3C/AGO2/POLR2A/DARS2/DHX32/TRPT1/RPP25/ISG20L2/MRM1/FBL/APEX1/DHX33/TRMT5/DDX39A/PPP1R8/NOP2/TYW1B/POLR3D/MEPCE/POLR1B/DIS3/THUMPD3/DHX40/DDX28/ELAC1/ISG20/DDX27/EXOSC5/DDX49/POLR1D/DDX20/DHX16/NSUN3/PUS3/DTWD1/DDX19A/DHX38/PNPT1/RPP21/TGS1/TRMT13/TRMT10C/TDP2/EIF4A3/SND1/POLR3E/POLR3B/USB1/DUS4L/EXO1/SKIV2L/JMJD6/NSUN4/FTSJ1/CNOT1/MTFMT/NSUN2/RPP30/DDX55/DHX36/DDX56/DHX34/EXOSC2/FARSA/POLR2D/POLR1A/CNOT6/TRNT1/RNASEL/TSEN2/ZCCHC4/TRMT10B/ALKBH3/POLR1E/DICER1/DHX9/ALKBH5/EIF4A2/DDX50/EARS2/PDE12/SUPV3L1/DDX41/DCP2/METTL16/YARS2/RNASE3/PRIM1/HELZ2/RRNAD1/METTL2B/NARS2/RNMT/FARSB/RPP14 GOBP_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS 1.58688405 0.000899916 0.014347893 TLR2/IL6/BIRC3/HIF1A/IL1R1/TRAF1/MIR125B1/CASP4/IRAK2/LAPTM5/PTPN1/PTPN2/TNFAIP3/SAMHD1/RFFL/IL1R2/TSLP/SOCS3/IFNGR1/TNFRSF1A/FADD/IRAK1/RNF113A/IRAK3/SUMO1/SPHK1/ABCE1/CSF1/ADAM17/OTUD4/IFNAR2/TRADD/TBK1/MAVS/MIR125A/CBFB/F2RL1/TTLL12/HSPA1B/HSP90AB1/BIRC2/RIPK1/MMP12/MIR26A1 GOMF_CYTOKINE_ACTIVITY 1.570522533 0.00068741 0.011939435 CXCL8/VEGFA/CXCL5/SPP1/NAMPT/CCL2/CCL20/LIF/IL6/BMP2/TIMP1/CCL7/PPBP/CXCL1/MIF/GDF15/TNFSF8/CLCF1/CXCL3/IL33/TSLP/TNFSF13/BMP1/MSMP/NDP/GDF11/C5/INHBA/CSF1/CKLF/GPI/GDF6/IFNE/CXCL6/CXCL16 GOBP_RESPONSE_TO_OXYGEN_LEVELS 1.721437741 1.48E-06 0.000121376 ANGPTL4/VEGFA/HMOX1/DDIT4/ADM/SOD2/TLR2/HILPDA/CA9/HK2/EGLN3/SLC2A1/ERO1A/PLOD2/BMP2/EIF4EBP1/HIF1A/MMP14/MYC/ITGA2/CDKN1A/NDRG1/PGK1/LDHA/PDPN/AGTRAP/SLC9A1/ENO1/LOXL2/HIPK2/PKM/PGF/HYOU1/NKX3-1/ZFP36L1/KCNK3/PTGS2/ICAM1/PTEN/BNIP3/PPARD/ITPR1/IRAK1/PDK1/P4HB/MALAT1/PSMA6/PSMD11/ADAM17/CASP3/PSMD12/SMAD3/PHB2/PSMB8/AK4/PSMB3/LONP1/AKT1/PSMD4/VHL/FAM162A/PLEKHN1/PLOD1/ATF4/PSMC4/BNIP3L/SRC/EPAS1/CPEB4/SIRT4/BIRC2/MTHFR/RORA/CXCL12/FAS/EGR1/TIGAR/ARNT/FOXO1/SLC11A2/ITPR2/TBL2/PSMC5/ADAM8 GOBP_RECEPTOR_SIGNALING_PATHWAY_VIA_STAT 1.507065134 0.004049532 0.041346452 CCL2/LIF/IL6/MIR125B1/BCL3/CYP1B1/CLCF1/PTPN2/STAT3/GADD45A/TSLP/SOCS3/TNFRSF1A/CD40/AGT/HGS/JAK3/IFNAR2/NMI/IFNE/VHL/MIR221/LYN/MIR125A/HCLS1/DOT1L/CRLF1/IL6ST/IL10RB/PARP9/HDAC2 GOBP_RESPONSE_TO_IONIZING_RADIATION 1.505148506 0.004128161 0.041738058 THBD/MYC/CCL7/CDKN1A/HSPA5/IFI16/CHEK2/GADD45A/TNKS1BP1/KRT14/ICAM1/NABP2/ECT2/CASP3/NABP1/AEN/NHEJ1/DCLRE1C/RRM1/ERCC1/IKBIP/XRCC4/BAK1/GPX1/RNF168/RAD51AP1/RAD51/EGR1/RFWD3/TIGAR/BRCC3/MEN1/PML/XRCC6/BAX/CLOCK/MDM2 GOBP_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS 1.607263459 0.000272829 0.006214107 VEGFA/HMOX1/HILPDA/CA9/EGLN3/ERO1A/EIF4EBP1/HIF1A/MYC/NDRG1/PGK1/SLC9A1/ENO1/HIPK2/HYOU1/NKX3-1/ZFP36L1/KCNK3/PTGS2/ICAM1/PTEN/BNIP3/PPARD/IRAK1/PDK1/P4HB/MALAT1/PSMA6/PSMD11/PSMD12/PHB2/PSMB8/AK4/PSMB3/AKT1/PSMD4/VHL/FAM162A/ATF4/PSMC4/BNIP3L/SRC/EPAS1/CPEB4/SIRT4/RORA/FAS/EGR1/TIGAR/ARNT/FOXO1/TBL2/PSMC5/ADAM8/RBPJ/UBB/UBC/AQP1/CACNB3/PSMA4/PSMB10/PSMD5/E2F1/PSME4/TERC/MDM2/NOL3/PSMD8 GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS 1.604464148 0.000252992 0.005882633 RPS4Y1/ZFP36L2/MRTO4/NOCT/TNKS1BP1/ZFP36L1/RPS3/RBM8A/XRN2/ZC3H12A/RPL28/MAGOHB/ZFP36/RPS2/UPF2/RPL12/PATL1/RPLP0/EXOSC8/RPL39/CASC3/CNOT8/SMG9/SMG7/SMG6/AGO2/EIF4G1/RPS10/RPL23/ETF1/RPS17/NCBP2/NT5C3B/RPL11/RPS18/SSB/RPL36A/LSM7/RPL13A/RPS20/RPSA/RPS6/CNOT11/DIS3/LSM4/RPS25/EXOSC5/CNOT10/EIF4A3/GSPT2/LSM2/RPL35A/SMG8/RPS26/RC3H1/RPL35/RPL18A/LSM6/SKIV2L/RNPS1/RPL26/CNOT1/UPF3B/MAGOH/DHX36/DHX34/EXOSC2/POLR2D/RPL24/CNOT6/UBA52/RPS11/DCP1A/RPS12/PDE12/THRAP3/DCP2/SMG1 GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT 1.635342023 7.26E-05 0.002564524 MVP/RRS1/FLOT1/ZFP36L1/SARNP/RBM8A/NXT1/AHCTF1/KHSRP/ABCE1/MAGOHB/ZFP36/UPF2/EIF5AL1/SEH1L/SIDT2/SLBP/XPOT/NUP188/RAN/SLC35B1/EIF5A/U2AF2/CASC3/ABCC4/SMG7/LTV1/SRSF4/SMG6/THOC3/SLC25A5/NUP98/XPO1/RIPK1/XPO5/NCBP2/SSB/POM121/SNUPN/DDX39A/NUP58/POM121B/G3BP2/FIP1L1/THOC5/SRSF9/SUPT6H/SLC17A9/POM121C/AKAP8L/NOP9/DDX19A/DHX38/TERF2/PNPT1/HNRNPA2B1/EIF4A3/CPSF2/TGFBR2/PABPN1/SLC25A17/SLC35A2/NUP35/HNRNPU/RNPS1/EIF6/RSC1A1/LSG1/NPM1/NSUN2/UPF3B/MAGOH/NDC1/POLR2D/NUP62/SRSF1/SYMPK/HSF1/DHX9/ALKBH5/RBM15B/POLDIP3/SMG1/NUP214/ALYREF/SRSF3/ZC3H11B/NUP155/TNKS/KHDRBS1/NOL6/RAE1/THOC1/NUP153/IWS1/PHAX/SMG5 GOBP_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY 1.570668169 0.000507363 0.010015183 TLR2/BIRC3/S100A9/IRAK2/NFKBIA/TNIP2/CTSL/TNFAIP3/FLOT1/IRAK4/TIFA/S100A8/MYD88/TLR5/CTSB/FADD/HSPD1/CD40/NR1D1/RELA/HAVCR2/IRAK1/LBP/MAPKAPK3/IRAK3/BCL10/NOD2/PIK3AP1/TNIP1/TRAF3/OTUD4/NMI/PHB2/TBK1/PHB/LYN/MFHAS1/CD14/BTK/TAB3/F2RL1/HSPA1B/BIRC2/RIPK1/UBE2D3/IRF1/CLEC4E/CLPB/UBB/UBC/PELI1/ITGB2/IKBKE/CACTIN/RPS6KA3/TLR1/RIPK2/APPL1/SLC15A4/SCIMP/UBE2V1/ARRB2/UBE2D1/ZCCHC3/C1QBP GOBP_POSITIVE_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY 1.619797199 0.000103276 0.003280502 VEGFA/TLR2/FOSL1/IL6/S100A9/TRAF1/IL1RAP/IRAK2/LRP8/HIPK2/FLOT2/STAT3/FLOT1/NKX3-1/RIPK4/S100A8/RPS3/BUD31/ICAM1/MYD88/PTEN/CD40/RELA/IRAK1/NFKB2/AGT/IL18R1/SAV1/PPRC1/MAP3K13/IRAK3/BCL10/NDP/NOD2/NLRC4/SPHK1/PSMA6/CIB1/CRTC2/SMAD3/TFRC/DDIT3/NFKB1/PHB2/CLU/TRADD/DDRGK1/TRIM8/S100A12/AKT1/MAVS/TNFRSF11A/HCLS1/BTK/TAB3/SMARCA4/HSPA1B/ARID5B/WNT2/RIPK1/TRIM27/PRKD1/DHX33/STK3/ADAM8 GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 1.520030534 0.00190297 0.025383857 RPS4Y1/RPL22L1/RPS3/LINC01004/MRPL52/RPL28/RPS2/RPL12/RPLP0/MRPL57/MRPL32/RPL39/RPS27L/RPS10/RPL23/MRPL12/RPS17/MRPL27/MRPL41/MRPL4/RPL11/RPS18/RPL36A/RPL13A/MRPS17/MRPS5/MRPS2/RPS20/RPSA/RPS6/MRPL30/MRPL21/RPS25/MRPL3/MRPL54/MRPL34/MRPS12/MRPL2/MRPL28/RPL35A/RPL7L1/RPS26/RPL35/RPL18A/RPLP0P6/RPL26/MRPL16/MRPL15/MRPS25/MRPL36/RPL24/MRPS15/UBA52/RPS11/MRPL46/MRPL1/RPS12/MRPS18B/MRPS18C/MRPS7/MRPL35/MRPL14 GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN 1.559604238 0.000675252 0.011794156 CXCL8/CCL2/ERO1A/HSPA6/SDF2L1/SHC1/HSPA5/DNAJB9/PTPN1/PTPN2/HSPA8/HYOU1/TSPYL2/ERN1/MANF/HDGF/BAG3/DNAJB11/HSPD1/SRPRB/ASNS/PDIA6/CREB3L1/EDEM2/DDIT3/DAXX/CLU/DDRGK1/ACADVL/DERL2/FICD/HSPA13/ATF4/CANX/XBP1/BAK1/HSPA1B/HSP90AB1/PPP1R15A/SERPINH1/CTDSP2/TBL2/DCTN1/FBXO6/EIF2S1/TMTC4/AUP1/HSPE1/BAX/GSK3A/ZBTB17/TOR1B GOMF_HELICASE_ACTIVITY 1.505691945 0.004135749 0.041746892 DDX3Y/RFC2/EIF4A1/DDX21/DDX23/DHX37/CHD3/DHX29/SLFN11/CHD8/CHD4/DHX32/SMARCA4/CHD1/RAD51/HELLS/DHX33/DDX39A/DHX40/DDX28/XRCC6/DDX27/DDX49/MCM2/DDX20/DHX16/RFC4/DDX19A/DHX38/EIF4A3/RAD54L2/SMC6/SKIV2L/MCM4/BLM/DDX55/DHX36/DDX56/HELB/DHX34/XRCC5/RUVBL1/DICER1/DHX9/EIF4A2/DDX50/EP400/SUPV3L1/DDX41/POLQ/HELZ2/MCM6/DDX31/SMARCAD1/G3BP1/DDX47 GOBP_NUCLEAR_EXPORT 1.560010941 0.000860029 0.013926204 TXN/RRS1/SARNP/BAG3/RBM8A/NXT1/ABCE1/MAGOHB/UPF2/SEH1L/SLBP/XPOT/NUP188/RAN/EIF5A/U2AF2/CASC3/SMG7/LTV1/SRSF4/SMG6/THOC3/NUP98/XPO1/UHMK1/STRADA/SP100/XPO5/NCBP2/RAPGEF3/SSB/POM121/DDX39A/NUP58/POM121B/FIP1L1/THOC5/SRSF9/SUPT6H/POM121C/AKAP8L/NOP9/DDX19A/GTSE1/DHX38/TGFB1/HNRNPA2B1/EIF4A3/CPSF2/HSPA9/PABPN1/YWHAE/NUP35/DESI1/RNPS1/EIF6/CSE1L/LSG1/NPM1/NSUN2/UPF3B/LZTS2/MAGOH/NDC1/TCF7L2/RITA1/POLR2D/NUP62/SRSF1/SYMPK/RBM22/XPO6/DHX9/ALKBH5/RBM15B/POLDIP3/SMG1/NUP214/CALR/ALYREF/AHCYL1/SRSF3/ZC3H11B/NUP155/KHDRBS1/NOL6/RAE1/THOC1/NUP153/IWS1/DNAJC27/PHAX/SMG5 GOBP_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR 1.52228868 0.002392829 0.029462598 SPRED3/SNAI2/CDK2/RFC2/MIF/RPF2/HIPK2/RRS1/CHEK2/MUC1/RFFL/PRMT5/TAF11/TAF5/TAF13/CHD3/NOC2L/AURKA/AKT1/SSRP1/CHD4/SPRED1/TAF3/RPL23/RPL11/NOP2/HDAC2/UBB/PML/AURKB/PRKAB2/HEXIM1/TAF6/RFC4/MDM2/EXO1/PAK1IP1/DYRK3/SUPT16H/RPL26/SNAI1/PRKAA1/CSNK2A1/BLM/RPA3/CSNK2B/TAF7/MTA2/ARMC10/TAF15/PPP1R13L/TAF2/TAF4/KAT6A GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE 1.618533487 9.06E-05 0.003079638 BIRC3/RELB/PLSCR1/LRP8/SLAMF8/PTPN1/PTPN2/TNFAIP3/IFI16/MUC1/SAMHD1/SOCS3/IFNGR1/VSIG4/FGR/TYROBP/FADD/RELA/HAVCR2/LBP/IRAK3/BCL10/LYAR/PQBP1/NOD2/NLRC4/SUMO1/ABCE1/PSMA6/PSMD11/FPR2/HCK/PSMD12/SIN3A/NFKB1/IFNAR2/NMI/PSMB8/TBK1/PSMB3/FCER1G/PSMD4/MAVS/LYN/POLR3C/PSMC4/SRC/TAB3/TTLL12/HSP90AB1/BIRC2/PVR/MMP12/IRF1/CD1D/PSMC5/ADAM8/CLEC4E/PARP9/POLR3D/NONO/IFNGR2/PSMA4/SERPING1/PSMB10/XRCC6/PSMD5/HEXIM1/AKIRIN2/IKBKE/CACTIN/PSME4/PRKCD/PSMD8/APPL1/SLC15A4/VAV1/PSME3/POLR3B/PYCARD/TRIM21/ARRB2/HMGB2/TREM2/ZCCHC3/PSMA3/MUL1/YTHDF3/PSMA1/RIOK3/PSMC2/XRCC5/PSMB5 GOBP_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE 1.491251696 0.003244116 0.035829331 IL6/BCL6/IL1R1/IL1RL1/SLC11A1/IL4R/NFKBIZ/CLCF1/IL33/TNFAIP3/MAD2L2/TNFSF13/SMAD7/ZBTB7B/FADD/HSPD1/CD40/HAVCR2/IL18R1/LOXL3/ZC3H12A/SASH3/NOD2/FZD5/JAK3/TFRC/BTK/IL20RB/CD274/SAMSN1/PVR/TRIM27/IL6ST/IRF1/CD1D GOCC_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS 1.586704401 0.000434024 0.008965986 CDKN1A/CDK2/POLR2H/PKM/PHKG1/ACVR1B/POLR2I/POLE3/POLR2L/ERN1/MAD2L2/POLR2K/SOCS3/TAF11/POLR1C/CCNG2/CKS2/MAP3K5/PHKA1/TAF5/LEO1/GTF2E2/PIK3R5/TAF13/POLE4/SESN2/PFKP/CKS1B/POLR3A/CDK1/PRPS2/POLD2/RMRP/POLE2/POLD3/POLR3C/POLR2A/TAF3/CCNK/POLD4/GTF2B/CCNE1/PRPS1/POLG2/CDK7/POLR3D/ACVR2B/REV3L/POLR1B/ATG14/PRKAB2/CCNE2/POLR1D/TAF6/CISH/CCNJ/ZBTB7A/TERC/PCNA/CDKN2D/TAF8/CTR9/POLR3E/POLR3B/PYCARD/SETD5/GTF2A2/PRKAA1/BECN1/GTF2F1/SOCS2/PFKL/POLR2D/TAF7/POLR1A/BCCIP/CCNB2/POLR1E/IRS1/TAF2/TAF4/PIK3R6/PAF1/CCNA2 GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS 1.493576384 0.003606018 0.038592461 VEGFA/THBD/SPP1/ADM/ITGA5/FOSL1/LIF/SLC2A1/TIMP1/ITGA2/RGS2/IGFBP5/VMP1/MAFF/APOL2/ACVR1B/B4GALT1/VDR/DAZAP1/PAPPA/PPARD/HAVCR2/ENDOU/EPOR/TEAD3/SERPINE2/SLC38A2/PPAT GOBP_MOVEMENT_IN_HOST_ENVIRONMENT 1.482555503 0.003837685 0.039971065 CXCL8/PTX3/ITGA5/ITGB3/CLEC5A/IFITM3/ITGA2/ANPEP/PLSCR1/IFITM2/CTSL/LDLR/CHMP4C/ICAM1/SLC1A5/P4HB/XPR1/CDK1/TFRC/TRIM8/PPID/PHB/NRP1/NPC1/SRC/VPS37B/CHMP4B/HSPA1B/PVR/TRIM27/HYAL3 GOBP_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 1.487867996 0.003328553 0.036502539 IL6/BCL6/RELB/SLC11A1/BCL3/ST3GAL1/IL4R/NFKBIZ/CLCF1/STAT3/MAD2L2/TNFSF13/ICAM1/SMAD7/ZBTB7B/RAB27A/HSPD1/RARA/CD40/HAVCR2/IL18R1/LOXL3/ZC3H12A/JAK3/TFRC/BATF/ENTPD7/FCER1G/IFNE/ERCC1/XBP1/F2RL1/RNF168/RORA GOBP_DNA_REPLICATION 1.594262514 8.26E-05 0.00284372 BCL6/CDK2/RFC2/CDC7/RRM2/BAZ1A/CHEK2/POLE3/SAMHD1/TOP1MT/TSPYL2/S100A11/DDX21/CLSPN/GTPBP4/RBMS1/NFIC/FEN1/HMGA1/DDX23/POLE4/TIMELESS/FAM111B/BRPF3/STOML2/RFC1/CDK1/SIN3A/POLD2/POLE2/SET/RRM2B/SLFN11/SSRP1/ZPR1/FBXO5/POLD3/RRM1/GMNN/CDC42/GINS1/POLD4/DBF4/DNAJC2/RAD51/CHAF1B/CCNE1/RFWD3/GINS4/POLG2/GRWD1/CACYBP/CDC45/NASP/REV3L/USP37/TTF1/NAP1L1/CCNE2/MCM10/NOC3L/MCMBP/MCM2/RFC4/ORC1/PCNA/TERF2/ZNF830/GINS3/DNAJA3/REPIN1/CDT1/ATG7/EXO1/SUPT16H/MCM4/ATAD5/BLM/RPA3/WAPL/HELB/ORC6/TOP1/ORC5/TBRG1/LIG3/PTMS/DHX9/CDC6/KIN/WDHD1/CCNA2 GOBP_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS 1.596516517 8.50E-05 0.002903902 IL6/CSTF2T/PLSCR1/RFC2/RNASE2/NOCT/RRS1/POLR2I/SAMHD1/RPP40/ERN1/NOP14/REXO2/ENPP2/FEN1/ENDOU/XRN2/POP1/ZC3H12A/NOB1/TSR1/ZFP36/RFC1/CASP3/POLD2/RMRP/EXOSC8/AEN/KRI1/DCLRE1C/CNOT8/ERI1/POLD3/TOE1/SMG6/ERCC1/AGO2/UTP20/POLD4/RPP25/ISG20L2/NCBP2/TATDN3/APEX1/NHP2/PPP1R8/DFFA/FIP1L1/ENDOD1/RRP36/TBL3/REV3L/UBB/DIS3/UBC/APEX2/ELAC1/ISG20/BAX/EXOSC5/NOP9/RFC4/PCNA/ABT1/TDP1/PNPT1/RPP21/TDP2/SND1/CPSF2/PMS2/USB1/HMGB2/KPNA1/EXO1/CUL4B/CNOT1/RPP30/RPA3/EXOSC2/CUL4A/NOL9/CNOT6/UBA52/RNASEL/TSEN2/DICER1/HSF1/DCP1A/TATDN2/HARBI1/PDE12/DCP2/POLQ/RNASE3/HELZ2 GOBP_RESPONSE_TO_TOXIC_SUBSTANCE 1.518917398 0.004170315 0.041891796 MT1X/MT2A/SOD2/TLR2/MT1M/MT1G/MT1E/ADH4/MT1A/MT1F/S100A9/CDKN1A/CYP1B1/ASS1/TXN/ALOX5AP/PIM1/KDM6B/PTGES/PTGS1/SLC7A11/PTGS2/GCH1/GSTO1/ASNS/SESN2/SLC7A8/NUPR1/PRDX6/LYN/ATF4/MT1DP/BAK1/GPX1/RAD51/NQO1/PRDX5/PRDX4 GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR 1.568691542 0.000529633 0.01031746 DDIT4/SPRED3/SNAI2/SOX4/CDKN1A/NDRG1/BCL3/CDK2/RFC2/MIF/RPF2/HIPK2/RRS1/IFI16/CHEK2/MUC1/GADD45A/RFFL/TNKS1BP1/PRMT5/TAF11/TAF5/TAF13/SESN2/CDK1/CHD3/BATF/NUPR1/NOC2L/AURKA/USP10/AEN/AKT1/SSRP1/CNOT8/CHD4/SPRED1/RPS27L/TAF3/RPL23/SP100/RPL11/NOP2/HDAC2/CNOT11/UBB/PML/AURKB/PRKAB2/MYBBP1A/BAX/HEXIM1/TAF6/CNOT10/E2F1/RFC4/SHISA5/MDM2/PCNA/GTSE1/CARM1/PYCARD/E2F4/EXO1/PAK1IP1/DYRK3/SUPT16H/RPL26/CNOT1/SNAI1/PRKAA1/CASP2/CSNK2A1/BLM/RPA3/CSNK2B/FOXM1/TAF7/MTA2/CNOT6/ARMC10/TAF15/PPP1R13L/TAF2/TAF4/KAT6A GOBP_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION 1.515174429 0.001505052 0.020936054 CDKN1A/CDK2/CDC7/CHMP4C/CLSPN/NABP2/TUBA4A/PSMA6/PSMD11/RCC2/HAUS6/CDK1/PSMD12/SIN3A/NABP1/BRD4/PSMB8/AURKA/PSMB3/PSMD4/CSNK1E/FBXO5/ODF2/CEP250/PSMC4/CDK5RAP2/BRCC3/PSMC5/KIF14/SYF2/USP47/DCTN1/HMMR/AURKB/CEP135/PSMA4/PSMB10/PSMD5/FOXO4/PSME4/ORC1/GTSE1/ZNF830/PSMD8/CNTRL/BRSK1/PSME3/YWHAE/DYRK3/ATAD5/PSMA3/NPM1/PLK1/PSMA1/BLM/VPS4A/HAUS2/PINX1/PSMC2/PSMB5/SSNA1/CEP57/HMGA2/PBX1/NAE1/CDC6/CEP63/PSMD2/APP/PSME1/PSMC1/HUS1B/HAUS1/PSMD14/TPX2/TUBG1/PSMD6/CCNB1/CEP41/GPR132/PSMB1/PSMB4/CEP131/YWHAG/TICRR/PSMA5/CUL1/PSMB7 GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 1.584860292 9.57E-05 0.003181094 CXCL8/CXCL5/THBD/ADM/SOD2/TLR2/CCL2/SERPINE1/CD68/IL6/SBNO2/S100A9/PPBP/SLC11A1/GGT5/IRAK2/ASS1/CXCL1/CEBPB/NFKBIA/TNIP2/TFPI/C5AR1/CXCL3/NOCT/TNFAIP3/PTGES/S100A8/ICAM1/MYD88/GCH1/PTGIR/CD40/NR1D1/RELA/PPARD/HAVCR2/IRAK1/LBP/NFKB2/LITAF/MAPKAPK3/IRAK3/ZC3H12A/BCL10/NFKBIB/NOD2/FZD5/AKAP8/ZFP36/ADAM17/HCK/TRIB1/CASP3/NFKB1/SIRPA/AKT1/CDK19/CXCL6/LYN/TNFRSF11A/AKAP12 GOBP_VIRAL_GENE_EXPRESSION 1.490748292 0.002437695 0.029662595 RPS4Y1/IFITM3/POLR2H/POLR2I/POLR2L/POLR2K/TAF11/RPS3/RPL28/ZFP36/RPS2/SEH1L/RPL12/RPLP0/NUP188/TRIM8/RRP1B/RPL39/UBP1/EIF3B/POLR2A/SMARCA4/RPS10/RPL23/CHD1/NUP98/DENR/RPS17/GTF2B/TRIM27/RPL11/RPS18/SSB/POM121/FURIN/RPL36A/RPL13A/NUP58/PTBP1/RPS20/RPSA/RPS6/EIF3D/NELFE/RPS25/HEXIM1/POM121C/SUPT5H/SMARCB1/RPL35A/TRIM21/RPS26/RPL35/TRIM62/NUP35/RPL18A/EIF3A/RPL26/MON1B/GTF2F1/NDC1/NELFCD/POLR2D/RPL24/NUP62/UBA52/USF1/HMGA2/RPS11 GOBP_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL 1.50975353 0.002699803 0.031496016 SOX4/BIRC3/HIF1A/ARRDC3/LAPTM5/HSPA5/TNFAIP3/MAD2L2/SPRY2/RPS3/SMAD7/GTPBP4/PTEN/RELA/ZMIZ1/ZC3H12A/BCL10/DTX3L/NOD2/SPHK1/RPS2/TNIP1/GNL3/FKBP1A/CBLB/OTUD4/NMI/DAXX/AKT1/SIAH2/U2AF2/FBXO5/EPAS1/RPL23/HSPA1B/HSP90AB1/AIMP2/PRMT3/GLMN/BIRC2/EGR1/ARNT/RPL11/LIMK1/ARRDC4/PHF23/GNL3L/UBB/PELI1/PLAA/GSK3A/RIPK2/FBXO2/TRIB3/RAB1A/CTR9/DCUN1D5/TRIM21/ARRB2/UBE2D1/UBE2S/SQSTM1/HDAC8/MAD2L1/MUL1/COMMD1/HDAC4/PLK1/DCUN1D3/UBXN1/PINX1/IVNS1ABP/HSPA1A/DCUN1D2/PRR7/RNF20/TRIP12/HUWE1/UBE2N/DNAJA1 GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS 1.538496688 0.001034796 0.015887314 CXCL8/CCL2/ERO1A/CASP4/SDF2L1/LPCAT3/CEBPB/SHC1/HSPA5/DNAJB9/PTPN1/PTPN2/PDIA4/HYOU1/FLOT1/TSPYL2/ERN1/MANF/UBE2J1/HDGF/DNAJB11/MAP3K5/BCL2L1/ITPR1/SRPRB/ASNS/P4HB/SESN2/RCN3/PDIA6/CREB3L1/EDEM2/DDIT3/TMEM67/RNFT1/CLU/DDRGK1/NUPR1/ACADVL/DERL2/FICD/ATF4/EIF4G1/CANX/XBP1/BAK1/UBXN8/PPP1R15A/CTDSP2/TBL2/DCTN1/FBXO6/EIF2S1/TMTC4/PML/AUP1/BAX/CCDC47/GSK3A/ZBTB17/HM13/TNFRSF10B/FBXO2/TRIB3/BCL2L11/BFAR/EDEM3/CREB3L4/DERL3 GOBP_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS 1.583513034 2.23E-05 0.00108982 IL6/SOX4/DIO2/EIF4EBP1/SHMT2/ITGA2/YBX3/MIR125B1/RGS2/IGFBP5/BCL3/GAPDH/ZFP36L2/PDK4/PKM/STAT3/LARP6/PUS7/MPV17L2/ZFP36L1/IFNGR1/TNFRSF1A/SLC7A11/RPS3/SARNP/NCL/RBM8A/KBTBD8/NOLC1/RELA/SMPD2/EIF2B2/PDK1/PRR16/PA2G4/ZC3H12A/NOD2/ORMDL2/SESN2/KHSRP/SPHK1/PPP1CA/ZFP36/EIF5/EIF1B/EIF5AL1/MIR134/EIF2B4/CASP3/NAT10/DHX29/DPH1/KLHL25/CLU/DPH2/AKT1/EIF5A/MIR222/ALKBH1/MIR221/CASC3/CNOT8/KRT17/EIF3B/PLEKHN1/ATF4/AGO2/MKNK2/EIF4G1/RPS27L/CPEB4/ETF1/UHMK1/GEMIN5/PPP1R15A/NCBP2/MIR659/PGAM1/TIGAR/TCOF1/MIR27A/RPL13A/GIGYF2/TACO1/LARP4/PDP2/MIRLET7I/TYMS/EIF2S1/CNOT11/EIF3D/MIRLET7E/PLXNB2/MIR877/HNRNPR/RPUSD3/MIR298/GSK3A/CNOT10/NSUN3/RPS6KA3/MIR361/PRKCD/TRMT10C/EIF4A3/EIF2B1/EIF4EBP3/CAPRIN1/RC3H1/CDC123/CNBP/MIR27B/C1QBP/EIF6/RPL26/CNOT1/NSMAF/EIF5B/PRKAA1/NCK1/NPM1/YTHDF3/IREB2/UPF3B/MAGOH/DHX36/PTAFR/PUM1/RTN2/POLR2D/CNOT6/NCK2/ZCCHC4/DHX9/FXR2/RBM4/EIF4A2/ACO1/POLDIP3/METAP1/MALSU1/APP/METTL16/CAPRIN2/EIF4G2/PICALM/DNAJC3/HNRNPD GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERACTION_WITH_HOST 1.455758407 0.003223699 0.03579457 CXCL8/PTX3/ITGA5/ITGB3/CLEC5A/IFITM3/ITGA2/ANPEP/PLSCR1/IFITM2/CTSL/HIPK2/LDLR/CHMP4C/ICAM1/BCL2L1/SLC1A5/P4HB/XPR1/TNIP1/CDK1/TFRC/PHB2/KPNA2/TRIM8/PPID/PHB/NRP1/TCP1/NPC1/THOC3/SRC/VPS37B/CHMP4B/HSPA1B/PVR/TRIM27/HYAL3 GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING 1.511284425 0.000715819 0.012194417 HSPA6/DIO2/UBASH3B/HIF1A/CDKN1A/TRAF1/NEK6/CEBPB/TPI1/NFKBIA/LAPTM5/HSPA5/HSPA8/ACVR1B/CHEK2/RFFL/UBE2J1/AXIN2/SMAD7/HSPD1/CD40/RELA/PA2G4/BCL10/DTX3L/HGS/SUMO1/CCT2/FZD5/LTBR/TRAF3/TRIB1/SMAD3/GPI/DAXX/CLU/DDRGK1/AURKA/TXNIP/PRDX6/LYN/CASC3/SKI/TCP1/MFHAS1/TRAF4/POLR2A/SRC/GGN/SLC25A5/RPL23/HSPA1B/HSP90AB1/GLMN/RIPK1/FOXO1/UBE2B/RPL11/MAP1LC3B/PARP9/SUMO3/CACYBP/WRAP53/ZNF746/UBB/PML/UBC/AUP1/RALB/IKBKE/HM13/BID/MDM2/TRIB3/STX8/TRIB2/RALA/SMC6/HSPA9/SCAMP3/YWHAE/ARRB2/UBE2D1/SQSTM1/UBXN7/CUL4B/ANKRA2/PSMA3/BECN1/MUL1/SNX9/BAG1/UQCRC1/UBXN1/TNFRSF14/HSPA7/HSPA1A/XRCC5/CUL4A/UBA52/STAM/PRR7/SUMO1P1/RRAGA/RNF20/ACTG1/NAE1/MC1R/UBE2N/DNAJA1 GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION 1.539570732 9.30E-05 0.003118274 HMOX1/TLR2/HILPDA/SERPINE1/IL6/HIF1A/HGF/IL1R1/IL1RL1/SAA1/SLC11A1/BCL3/IL1RAP/CYP1B1/MIF/CEBPB/SLC7A5/LAPTM5/GAPDH/IL4R/C5AR1/PANX1/POLR2H/IL33/STAT3/IFI16/FLOT1/LURAP1/POLR2L/TSLP/DDX21/POLR2K/IFNGR1/PTGS2/RPS3/MYD88/POLR1C/TLR5/FGR/TYROBP/FADD/HSPD1/RARA/CD40/RELA/HAVCR2/ORM2/IRAK1/LBP/NFKB2/AGT/IL18R1/BCL10/PQBP1/SASH3/PDE4D/NOD2/NLRC4/IL1RL2/MAPK13/SPHK1/C5/FZD5/ADAM17/POLR3A/SMAD3/DDIT3/NFKB1/CLU/TBK1/FCER1G/MAVS/CD14/POLR3C/CLEC7A/ATF4/SULF1/XBP1/F2RL1/IL20RB/HSPA1B/CD274/GLMN/RORA/RIPK1/MMP12/EGR1/ARNT/IL6ST/DHX33/FURIN/IRF1 GOCC_CHROMOSOMAL_REGION 1.498095882 0.000510693 0.010049016 CEBPB/CHEK2/NABP2/FEN1/ZWINT/AHCTF1/CENPU/PPP1CA/RCC2/ITGB3BP/CDK1/GAR1/SEH1L/ACD/NAT10/SIN3A/NABP1/DAXX/NCAPG/CENPN/LRIF1/SMG6/ERCC1/CENPL/THOC3/DOT1L/NUP98/XPO1/RAD51AP1/SKA1/RAD51/SP100/SPAG5/SS18L1/TOX4/HELLS/SSB/APEX1/NHP2/CENPB/CENPO/CSNK1A1/SUMO3/SKA3/INCENP/DCTN1/THOC5/MEN1/WRAP53/TTK/ZNF330/PML/AURKB/SPC25/PTGES3/BUB1B/BIRC5/PELI1/XRCC6/EZH2/UHRF2/NUF2/SPC24/MCM2/TEP1/BUB3/TERC/GPATCH11/ORC1/PCNA/TERF2/HNRNPA2B1/SMC6/CDT1/KIF2C/SUV39H2/HMBOX1/TINF2/HNRNPU/SUGT1/MAD2L1/MCM4/SNAI1/HJURP/PLK1/BLM/DHX36/MIS12/WAPL/PINX1/CBX3/NSMCE1/XRCC5/ZW10/POT1/BOD1/ORC5/TOP2A/HSF1/EID3/SPDL1/CHAMP1/PPP1CC/ALYREF/TNKS/MCM6/CDCA5/SMC5/CENPK/THOC1/HAT1/DCLRE1B/TFIP11/CBX5/CCNB1 GOBP_CELL_CYCLE_G1_S_PHASE_TRANSITION 1.471116229 0.00209657 0.027216021 CCL2/SOX4/EIF4EBP1/MYC/CDKN1A/CDK2/CDC7/RRM2/E2F3/CDK18/ACVR1B/CHEK2/POLE3/MUC1/GADD45A/TNKS1BP1/BCAT1/JADE1/PTEN/POLE4/INHBA/ADAM17/CDK1/MIR30C2/PPAT/POLE2/PHB2/BRD4/DDRGK1/AURKA/AKT1/MIR222/MIR221/SLFN11/CDKN3/CDK17/ZPR1/CNOT8/FBXO5/GMNN/EIF4G1/RPS27L/STXBP4/DBF4/MIR26A1/CCNE1/RFWD3/CTDSP2/APEX1/CDK7/KIF14/CDC45/SPDYA/CDK2AP2/MEPCE/NASP/TYMS/RPS6/CNOT11/PML/USP37/CCNE2/EZH2/MCM10/BAX/MCM2/ADAMTS1/CNOT10/BID/E2F1/MDM2/ORC1/PCNA/GTSE1/KMT2E/CDKN2D/APPL1/CARM1/PSME3/CDT1/E2F4/CUL4B/MCM4/RPL26/CNOT1/CASP2/RBL1/DCUN1D3/RPA3/CDK16/BACH1/CUL4A/IQGAP3/ORC6/CNOT6/RCC1 GOMF_MRNA_BINDING 1.492116799 0.000556931 0.010519472 SHMT2/YBX3/MIR125B1/CSTF2T/MIR146B/ZFP36L2/MIR573/PKM/NOCT/EIF4A1/LARP6/MIRLET7G/ZFP36L1/MIR548C/RPS3/EIF2S2/MIR193B/RBMS1/MIR511/NCL/MIR2355/RBM8A/DAZAP1/RBM47/KHDRBS3/ZC3H12A/KHSRP/ZFP36/RPS2/MIR134/GNL3/FUBP1/MIR30C2/SNRPC/SLBP/EXOSC8/MIR222/PCBP1/MIR221/MIR125A/MIR487B/RBPMS/SRSF4/PABPC4/AGO2/EIF4G1/CPEB4/ETF1/NUP98/DENR/GEMIN5/XPO5/NCBP2/MIR659/MIR374B/HNRNPC/MIR425/MIR26A1/SSB/DHX33/MIR27A/PPP1R8/RPL13A/NSRP1/TACO1/MIR657/LARP4/PTBP1/G3BP2/CCT5/MIR505/THOC5/MIRLET7I/TYMS/PTBP3/MBD2/EIF3D/MIRLET7E/MIR877/HNRNPR/MIRLET7F1/MIR298/SNRNP35/RSL1D1/MIR1277/SERBP1/MIR148B/MIR361/SF3B6/HNRNPAB/MIR613/HNRNPA2B1/SUPT5H/EIF4A3/MIR320A/RPS26/RC3H1/RPL35/RBMS3/MIR147A/HNRNPU/CNBP/MIR30C1/MIR27B/RNPS1/C1QBP/EIF3A/RPL26/MIR411/YTHDF3/IREB2/UPF3B/MIR25/MIR661/DHX36/MIR758/PUM1/TRA2B/MIR3909/SRSF1/MIR219A1/RNF20/DHX9/FXR2/RBM4/DCP1A/ACO1 GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION 1.417136715 0.005341627 0.049787883 CCL2/SOX4/CDKN1A/CDK2/ZFP36L2/CHEK2/MUC1/GADD45A/TNKS1BP1/MAD2L2/ZFP36L1/CHMP4C/CLSPN/JADE1/PTEN/NABP2/ZWINT/PSMA6/PSMD11/CDK1/MIR30C2/PSMD12/NABP1/PSMB8/AURKA/PSMB3/PSMD4/SLFN11/CNOT8/FBXO5/PSMC4/RPS27L/CDK5RAP2/MIR26A1/RFWD3/CTDSP2/BRCC3/PSMC5/SYF2/USP47/CDK2AP2/TTK/CNOT11/PML/AURKB/PSMA4/BUB1B/PSMB10/EZH2/PSMD5/BAX/FOXO4/CNOT10/BUB3/E2F1/PSME4/MDM2/ORC1/PCNA/GTSE1/ZNF830/CDKN2D/PSMD8/BRSK1/CARM1/PSME3/CDT1/E2F4/MAD2L1/RPL26/CNOT1/PSMA3/CASP2/RBL1/PLK1/PSMA1/BLM/VPS4A/DCUN1D3/PINX1/PSMC2/ZW10/PSMB5/CNOT6/HMGA2 GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL 1.433271194 0.002507426 0.030101586 BIRC3/HIF1A/MYC/SHMT2/NFKBIA/TNIP2/USP9Y/IL33/TNFAIP3/TFPT/CLSPN/SMAD7/USP54/PTEN/USP53/ZC3H12A/HGS/PSMA6/PSMD11/TNIP1/TRAF3/CDK1/PSMD12/RAD23A/SMAD3/OTUD4/PSMB8/USP10/PSMB3/PSMD4/SIAH2/COPS2/PSMC4/BIRC2/RIPK1/BRCC3/PSMC5/KDM1B/USP47/UBB/UBC/ACTL6A/USP37/PSMA4/PSMB10/JOSD1/USP22/PSMD5/RAD23B/FOXO4/SNX3/PSME4/MDM2/USP36/PSMD8/USP27X/PSME3/TRIM21/ASXL2/OTUD7B/ARRB2/UBE2D1/RCE1/DESI1/ASXL1/PSMA3/BECN1/PSMA1/UBXN1/PSMC2/PSMB5/UBA52/STAM/RUVBL1/BAP1/CCNA2/PSMD2/OTULIN/PSME1/MDM4/KEAP1/NEDD8/PSMC1/SUDS3/ADRM1/USP3/CCNA1/MYSM1/PSMD14/USP7/USP32/PSMD6/HCFC1/RNF123/CDC20/USP38/PSMB1/PSMB4/SMURF2/TADA2B/USP8/PSMA5/ACTR8/PSMB7/FOXK2/INO80 GOBP_ATP_METABOLIC_PROCESS 1.431392409 0.003888348 0.040229193 DDIT4/FAM20C/HK2/HIF1A/SHMT2/NDUFC2-KCTD14/PGK1/LDHA/GCKR/TPI1/GAPDH/ENO1/HSPA8/PKM/ALDOC/COA6/PPIF/HK3/NUDT5/SDHAF2/PFKP/AK1/STOML2/CDK1/SEH1L/BEND3/COX7B/GPI/NUP188/NUPR1/ENO2/AK4/NDUFA3/AK2/PGM1/PFKFB4/HSPA1B/NDUFV2/NUP98/NDUFS5/NDUFB11/PGAM1/TIGAR/ARNT/POM121/NUP58/NDUFB4/ATP6V1B2/POM121C/BID/ZBTB7A/NDUFC2/NDUFS6/TGFB1/PGM2L1/NDUFB9/NUP35/TREM2/BPGM/SLC2A6/TEFM/EIF6/PRKAA1/FXN/PGAM4/HDAC4/SURF1/PFKL/GALK1/UQCRC1/NDUFAB1/NDC1/UQCRQ GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS 1.434107767 0.001778717 0.024084685 CCL2/LIF/BCL6/SOX4/CDKN1A/CDK2/MIF/ZFP36L2/CDC7/RRM2/CHEK2/MUC1/GADD45A/PTTG1/TNKS1BP1/MAD2L2/ZFP36L1/CHMP4C/CLSPN/JADE1/PTEN/NABP2/ZWINT/PSMA6/PSMD11/CDK1/MIR30C2/PSMD12/TMEM67/NABP1/PSMB8/AURKA/PSMB3/PSMD4/SLFN11/CNOT8/FBXO5/RYBP/PSMC4/RPS27L/RPL23/HSP90AB1/CDK5RAP2/RAD51/RING1/MIR26A1/RFWD3/CTDSP2/BRCC3/PSMC5/SYF2/USP47/CDK2AP2/TTK/CNOT11/PML/AURKB/PSMA4/BUB1B/ESPL1/PSMB10/EZH2/PSMD5/BAX/FOXO4/CNOT10/BUB3/E2F1/PSME4/MDM2/ORC1/PCNA/GTSE1/TERF2/ZNF830/CDKN2D/PSMD8/BRSK1/CARM1/PSME3/CDT1/E2F4/MAD2L1/YAF2/RPL26/CNOT1/PSMA3/CASP2/NPM1/RBL1/PLK1/PSMA1/BLM/VPS4A/DCUN1D3/WAPL/PINX1/CBX3/PCGF2/PSMC2/ZW10/PSMB5/CNOT6/DAB2IP/HMGA2 GOBP_REGULATION_OF_INFLAMMATORY_RESPONSE 1.425084554 0.00253267 0.030284887 TLR2/SERPINE1/TGM2/IL6/BCL6/SBNO2/OSMR/BIRC3/HGF/IL1R1/IL1RL1/S100A9/ITGA2/SAA1/CASP4/LPCAT3/CEBPB/NFKBIA/SIGLEC10/NFKBIZ/SLAMF8/PTPN2/IL33/TNFAIP3/NEAT1/C2CD4A/TSLP/FNDC4/PTGES/MIRLET7G/CTSC/SOCS3/LDLR/S100A8/TNFRSF1A/PTGS2/MYD88/NT5E/NR1D1/RELA/PPARD/LBP/AGT/TNFAIP8L2/NOD2/PIK3AP1/IL1RL2/MAPK13/SPHK1/PSMA6/PLA2G7/FPR2/TNIP1/HCK/MIR30C2/SMAD3/NFKB1/NMI/SIRPA/TRADD/AKNA/BRD4/NUPR1/MMP3/S100A12/CDK19/MIR222/MIR221/LYN/TNFRSF11A GOBP_VIRAL_LIFE_CYCLE 1.415187777 0.002052081 0.02675019 CXCL8/PTX3/CCL2/ITGA5/ITGB3/CLEC5A/IFITM3/ITGA2/ANPEP/PLSCR1/TMEM39B/IFITM2/CTSL/HSPA8/IFI16/UBAP1/LDLR/CHMP4C/ICAM1/SLC1A5/CHMP4A/ZC3H12A/P4HB/RAB29/XPR1/TNIP1/CDK1/SEH1L/RAD23A/TFRC/STOM/NUP188/RAN/KPNA2/TRIM8/PPID/MIR222/PCBP1/PHB/MIR221/MAVS/NRP1/NPC1/VPS37B/SNF8/CHMP4B/CDC42/HSPA1B/CCNK/HSP90AB1/NUP98/XPO1/SRPK1/VPS37C/PVR/TRIM27/HYAL3/POM121/FURIN/NUP58/ZC3HAV1/RPSA/TRIM22/STAU1/UBB/PML/UBC/ISG20/DEK GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS 1.412228488 0.001311152 0.018959869 HMOX1/SOD2/ERRFI1/IL6/SLC2A1/ERO1A/HIF1A/PDGFRA/HGF/RELB/YBX3/CDK2/ARNTL/CYP1B1/TXN/AKR1C3/TNFAIP3/KDM6B/ERN1/ZFP36L1/SLC7A11/MCL1/RPS3/MAP3K5/GCH1/RELA/PPIF/BNIP3/NCOA7/PDK1/ZC3H12A/MELK/STK24/P4HB/MAPK13/SESN2/SPHK1/ECT2/NCF2/ROMO1/CASP3/DDIT3/SIN3A/SIRPA/MMP3/LONP1/AKT1/PRDX6/STX4/ATF4/GLRX2/SRC/EPAS1/BTK/HSPA1B/GPX1/SERPINB6/ZNF622/NQO1/NME2/RIPK1/PRDX5/FAS/ARNT/FOXO1/PRKD1/APEX1/PDE8A/HDAC2/STAU1/EIF2S1/NONO/PML/AQP1/MAPKAP1/TMEM161A/XRCC6/EZH2/SLC1A1/ARHGEF2/GSKIP/PCNA/PRKCD/AXL/NOL3/PNPT1 GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS 1.43872957 0.000876012 0.01401106 BIRC3/TRAF3IP2/RELB/PLSCR1/LRP8/SLAMF8/PTPN1/PTPN2/TNFAIP3/IFI16/ARG2/MUC1/SAMHD1/SOCS3/IFNGR1/VSIG4/FGR/TYROBP/FADD/HSPD1/RELA/HAVCR2/LBP/IRAK3/ZC3H12A/BCL10/LYAR/PQBP1/DTX3L/NOD2/NLRC4/SUMO1/ABCE1/PSMA6/PSMD11/FPR2/TRAF3/HCK/TRIB1/PSMD12/SIN3A/NFKB1/IFNAR2/NMI/PSMB8/TBK1/PSMB3/FCER1G/PSMD4/CXCL6/MAVS/LYN/POLR3C/PSMC4/SRC/TAB3/F2RL1/TTLL12/CD274/HSP90AB1/BIRC2/PVR/MMP12/TIGAR/IRF1/CD1D/PSMC5/ADAM8/CLEC4E/PARP9/POLR3D/IL2RA/NONO/IFNGR2/PSMA4/SERPING1/PSMB10/XRCC6/PSMD5/HEXIM1/AKIRIN2/IKBKE/CACTIN/PSME4/RIPK2/PRKCD/TRAF3IP1/PSMD8/APPL1/SLC15A4/SCIMP/VAV1/PSME3/POLR3B/PYCARD/TRIM21/ARRB2/HMGB2/CD180/TREM2/ZCCHC3/C1QBP/PSMA3/LY86/MUL1/YTHDF3/PSMA1/PUM1/RIOK3/PSMC2/ZDHHC1/XRCC5/PSMB5 GOBP_DNA_REPAIR 1.472971215 0.000113033 0.003453649 CDK2/RFC2/PRRX1/CDC7/POLR2H/ALKBH2/CHEK2/POLR2I/SAMHD1/GADD45A/PTTG1/POLR2L/TNKS1BP1/MAD2L2/POLR2K/RPS3/TFPT/AXIN2/CLSPN/ASCC1/NABP2/FEN1/RNF113A/DTX3L/TIMELESS/SUMO1/POLM/CIB1/RFC1/CDK1/RAD23A/POLD2/NABP1/POLE2/EEPD1/USP10/PMS2P1/RRM2B/NHEJ1/DCLRE1C/ALKBH1/MIR221/SSRP1/CSNK1E/POLD3/KDM2A/COPS2/UBQLN4/ERCC1/XRCC4/POLR2A/GGN/DOT1L/POLDIP2/RNF168/POLD4/RAD51AP1/RAD51/RNF169/CHAF1B/UBE2D3/RFWD3/TIGAR/UBE2B/APEX1/BRCC3/GINS4/HMGN1/POLG2/CDK7/PARP9/NUDT1/USP47/CDC45/FBXO6/MEN1/WRAP53/REV3L/NONO/UBB/PML/UBC/ACTL6A/APEX2/ZSWIM7/TMEM161A/FUS/DEK/XRCC6/PARP3/RAD23B/MCM2/PSME4/ZBTB7A/RFC4/PCNA/TERF2/TDP1/ZNF830/CDKN2D/TDP2/SMC6/UBE2V1/PMS2/HMGB2/PPP4C/EXO1/SUPT16H/CUL4B/MSH4/MCM4/RNF138/NPM1/COMMD1/PRPF19/BLM/RPA3/HELB/DMAP1/UHRF1/BACH1/NSMCE1/FOXM1/XRCC5/CUL4A/POLR2D/BCCIP/POT1/UBA52/RUVBL1/HMGA2/ALKBH3/LIG3/TRIP12/HSF1/MC1R/DHX9/ALKBH5/HUWE1/EID3/KIN/UBE2N/WDHD1/SMG1/POLQ/PPP4R2/HUS1B/USP3/MCM6/GINS2/TDG/CDCA5/PPP5C/SMC5/TTC5/POLG/PSMD14/WAS/UBE2T/SMARCAD1/USP7/DCLRE1B/TWIST1/TFIP11/POLR2J/TEX12/XRCC2/FANCI/EME1/HINFP/PMS1/BRCA2/SLF1/ZFYVE26/SMC3/UPF1/GEN1/TICRR/FAM168A/ACTR8/SMC1A/MGME1/PRKDC/KAT7/INO80/RFC5 GOBP_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS 1.433633975 0.001978029 0.025948074 CSTF2T/HSPA8/POLR2H/POLR2I/POLR2L/RBM7/POLR2K/SNRPD1/PRMT5/BUD31/SF3B5/NCL/RBM8A/DAZAP1/SNRPF/HNRNPF/RNF113A/KHDRBS3/DDX23/SRSF12/WTAP/PQBP1/KHSRP/MAGOHB/SNRPA1/SNRPC/PRPF4/STRAP/RNVU1-1/RBMXL1/CWC27/PCBP1/PRDX6/U2AF2/CASC3/SNRPD2/PDCD7/SRSF4/CCAR1/CTNNBL1/POLR2A/CWC22/EFTUD2/NUP98/RBM42/GEMIN5/SRPK1/NCBP2/HNRNPC/SNRPG/HNRNPH3/CLP1/HNRNPA3/CHERP/SNUPN/GEMIN6/PPIL3/CSTF1/LSM7/PRPF40A/DDX39A/SUGP1/NSRP1/PAPOLA/PTBP1/FIP1L1/SYF2/CD2BP2/BCAS2/NONO/LSM4/SRSF9/MFAP1/FUS/HNRNPR/SNRNP35/DDX20/RBM19/DHX16/CACTIN/ZBTB7A/SF3B6/DHX38/NOL3/PRPF4B/TGS1/SNRPE/HNRNPA2B1/SMN2/WBP11/SF3A1/EIF4A3/SRRT/RNVU1-7/DNAJC8/CPSF2/LSM2/SNRNP48/PABPN1/SMU1/PRPF31/LSM6/HNRNPU/MPHOSPH10/U2AF1L5/RNPS1/C1QBP/JMJD6/GPATCH1/GTF2F1/SF3B4/PRPF19/UPF3B/MAGOH/SF3B3/POLR2D/TRA2B/CLNS1A/SRSF1/SF3A3/SYMPK/RBM22/AAR2/DHX9/FXR2/RBM4/SNRPA/RBM15B/THRAP3/DDX41/METTL16/HNRNPD/ZC3H10/SNIP1/ZCRB1/HNRNPM/ALYREF/ZMAT2/SRSF3/SNRPB2/LSM5/HNRNPH1/SFSWAP/GCFC2/KHDRBS1 GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE 1.403410093 0.002447605 0.02972501 TLR2/SERPINE1/TGM2/IL6/OSMR/IL1RL1/RELB/S100A9/ITGA2/PLSCR1/CEBPB/NFKBIA/NFKBIZ/IL33/NEAT1/IFI16/C2CD4A/MUC1/TSLP/CTSC/S100A8/TNFRSF1A/PTGS2/TYROBP/FADD/RELA/HAVCR2/LBP/AGT/BCL10/PQBP1/NOD2/NLRC4/MAPK13/PSMA6/PSMD11/PLA2G7/FPR2/TNIP1/HCK/PSMD12/SIN3A/NFKB1/NMI/TRADD/NUPR1/PSMB8/TBK1/S100A12/PSMB3/FCER1G/PSMD4/CDK19/MAVS/LYN/TNFRSF11A/POLR3C/PSMC4/SRC/BTK/TAB3/F2RL1/PVR/RIPK1/MMP12/IL6ST/CD1D/PSMC5/ADAM8/CLEC4E/PARP9/POLR3D/NONO/PSMA4/PSMB10/XRCC6/PSMD5/HEXIM1/AKIRIN2/IKBKE/CLOCK/PSME4 GOBP_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY 1.465261307 0.000149216 0.004198296 SERPINA3/HMOX1/PTX3/SERPINA1/TLR2/CD68/PNP/IL6/PYGL/HSPA6/PLAUR/FTH1/CLEC5A/S100A9/ANPEP/PPBP/FPR1/SLC11A1/OLR1/RNASE2/CXCL1/MIF/SLC2A3/SIGLEC9/IL4R/MCEMP1/MVP/C5AR1/HSPA8/PKM/LPCAT1/SERPINB1/ALDOC/B4GALT1/CKAP4/IRAK4/S100A11/DDX21/CTSC/IL13RA2/S100A8/CD53/JAGN1/CD59/RAB27A/CANT1/FGR/CTSB/TYROBP/ORM2/HK3/LAIR1/PA2G4/IMPDH2/PSMD11/CCT2/ADGRE2/CD63/ADAM17/FPR2/PSMD12/STOM/PLEKHO2/NFKB1/IMPDH1/GPI/SIRPA/SLC2A5/LILRB3/S100A12/PDXK/FCER1G/MILR1/PRDX6/RAB3D/CXCL6/MAVS/LYN/STX4/FTL/CD14/FABP5/BTK/ARMC8/PGM1/F2RL1/HSPA1B/SERPINB6/HSP90AB1/CSTB/NME2/CYSTM1/RAC2/PRDX4/PGAM1 GOBP_MRNA_PROCESSING 1.434399452 0.000348537 0.007525015 CSTF2T/HSPA8/POLR2H/POLR2I/POLR2L/ERN1/RBM7/POLR2K/SNRPD1/ZFP36L1/PRMT5/BUD31/SF3B5/SARNP/NCL/RBM8A/DAZAP1/SNRPF/HNRNPF/LEO1/XRN2/RNF113A/KHDRBS3/DDX23/SRSF12/WTAP/PQBP1/KHSRP/MAGOHB/SNRPA1/SNRPC/PRPF4/STRAP/RNVU1-1/SLBP/RBMXL1/CLASRP/CWC27/PDCD11/RRP1B/PCBP1/PRDX6/U2AF2/CASC3/ZPR1/SNRPD2/PDCD7/SRSF4/CCAR1/CTNNBL1/POLR2A/CWC22/THOC3/EFTUD2/NUP98/RBM42/GEMIN5/SRPK1/NCBP2/HNRNPC/SNRPG/HNRNPH3/CLP1/HNRNPA3/CHERP/SNUPN/GEMIN6/PPIL3/CSTF1/LSM7/PRPF40A/DDX39A/PPP1R8/SUGP1/CDK7/NSRP1/PAPOLA/PTBP1/FIP1L1/SYF2/THOC5/CD2BP2/BCAS2/NONO/PTBP3/LSM4/SRSF9/NELFE/MFAP1/FUS/SUPT6H/HNRNPR/RPUSD3/SNRNP35/AKAP8L/DDX20/RBM19/DHX16/CACTIN/ZBTB7A/SF3B6/DHX38/NOL3/PNPT1/PRPF4B/TGS1/ZNF830/SNRPE/HNRNPA2B1/SMN2/WBP11/SF3A1/SUPT5H/SAFB2/EIF4A3/SRRT/RNVU1-7/CTR9/DNAJC8/CPSF2/ZNF473/LSM2/SNRNP48/PABPN1/SMU1/PRPF31/SSU72/LSM6/HNRNPU/U2AF1L5/PRPF38B/RNPS1/C1QBP/JMJD6/TBRG4/RBM28/GPATCH1/GTF2F1/SF3B4/PRPF19/UPF3B/MAGOH/DHX36/SF3B3/POLR2D/TRA2B/CLNS1A/SRSF1/SF3A3/RNASEL/TSEN2/SYMPK/RBM22/AAR2/RNF20/SREK1/TCERG1/HSF1/DHX9/ALKBH5/FXR2/RBM4/KIN/SNRPA/PAF1/RBM15B/POLDIP3/APP/PDE12/THRAP3/DDX41/METTL16/HNRNPD/ZC3H10/SNIP1/ZCRB1/PPP4R2/HNRNPM/ALYREF/ZMAT2/SLTM/AHCYL1/SRSF3/RNMT/CDK12/SNRPB2/LSM5/HNRNPH1/SFSWAP/ZNF326/GCFC2/KHDRBS1/THOC1/COIL/DYRK1A/IWS1/TFIP11/RNVU1-6/DDX47/POLR2J/CCNB1/HNRNPH2/RPRD1B/SYNCRIP/SAFB/DDX46/STH/LSM1 GOBP_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY 1.37233906 0.002876646 0.032854884 HMOX1/SOD2/SERPINE1/SNAI2/PLAUR/HIF1A/HGF/S100A9/TRAF1/YBX3/MIF/PTPN1/PTPN2/ENO1/TNFAIP3/MUC1/HYOU1/NKX3-1/RFFL/ITPRIP/CTSC/PLAGL2/S100A8/MCL1/RPS3/ICAM1/PTEN/AATF/FADD/NOG/BCL2L1/RELA/GCLM/PPIF/AGT/BCL10/P4HB/STK4/PPP1CA/INHBA/LTBR/PRELID1/CREB3L1/DDIT3/CLU/TRADD/NUPR1/SLC35F6/NOC2L/AKT1/SIAH2/MIR222/MIR221/STX4/XBP1/SRC/SLC25A5/HSPA1B/GPX1/SP100/CXCL12/RIPK1/NLE1/FAS/RPL11/STK3/URI1/FEM1B/USP47/NONO/UBB/PML/TMEM161A/BAX/STYXL1/HTT/ARHGEF2/TNFRSF10B/BID/MDM2/PRKCD/NOL3/CDKN2D/BCL2L11/PPP2R1B/PRKRA/PSME3/PYCARD/TRAF7/ARRB2/HMGB2/MMP9/MIR27B/RPL26/SNAI1/BCL2L2/NCK1/BECN1/FXN/CASP2/CSNK2A1/TXNDC12/PIH1D1 GOBP_RNA_SPLICING 1.415686546 0.000530291 0.01031746 CSTF2T/HSPA8/POLR2H/POLR2I/POLR2L/ERN1/RBM7/POLR2K/SNRPD1/PRMT5/BUD31/SF3B5/PPP1R9B/NCL/RBM8A/DAZAP1/SNRPF/HNRNPF/RNF113A/KHDRBS3/DDX23/SRSF12/WTAP/PQBP1/KHSRP/MAGOHB/AHNAK2/SNRPA1/SNRPC/PRPF4/SLC38A2/STRAP/RNVU1-1/RBMXL1/CLASRP/CWC27/RRP1B/PCBP1/PRDX6/U2AF2/CASC3/ZPR1/SNRPD2/PDCD7/SRSF4/CCAR1/CTNNBL1/POLR2A/CWC22/THOC3/EFTUD2/TRPT1/NUP98/RBM42/GEMIN5/SRPK1/NCBP2/HNRNPC/SNRPG/HNRNPH3/CLP1/HNRNPA3/CHERP/SNUPN/GEMIN6/ZBTB8OS/PPIL3/CSTF1/LSM7/PRPF40A/DDX39A/PPP1R8/SUGP1/NSRP1/PAPOLA/PTBP1/FIP1L1/SYF2/THOC5/CD2BP2/BCAS2/NONO/PTBP3/LSM4/SRSF9/MFAP1/FUS/SUPT6H/HNRNPR/SNRNP35/AKAP8L/DDX20/RBM19/DHX16/CACTIN/ZBTB7A/SF3B6/DHX38/NOL3/PRPF4B/TGS1/ZNF830/SNRPE/HNRNPA2B1/SMN2/WBP11/SF3A1/EIF4A3/SRRT/RNVU1-7/RRAGC/DNAJC8/CPSF2/LSM2/SNRNP48/PABPN1/SMU1/USB1/PRPF31/RPS26/LSM6/HNRNPU/MPHOSPH10/U2AF1L5/PRPF38B/RNPS1/C1QBP/JMJD6/RBM28/GPATCH1/GTF2F1/SF3B4/PRPF19/UPF3B/MAGOH/SF3B3/IVNS1ABP/HSPA1A/POLR2D/TRA2B/CLNS1A/SRSF1/SF3A3/TSEN2/SYMPK/RBM22/AAR2/SREK1/TCERG1/DHX9/FXR2/RBM4/SNRPA/RBM15B/THRAP3/DDX41/METTL16/HNRNPD/ZC3H10/SNIP1/ZCRB1/PPP4R2/HNRNPM/ALYREF/ZMAT2/SRSF3/CDK12/SNRPB2/LSM5/HNRNPH1/SFSWAP/ZNF326/GCFC2/KHDRBS1/THOC1/COIL/DYRK1A/IWS1/TFIP11/RNVU1-6/DDX47 GOBP_CELLULAR_RESPONSE_TO_LIPID 1.419589268 0.000549266 0.010476499 TNC/CXCL8/CXCL5/SPP1/DDIT4/TLR2/CCL2/ERRFI1/SERPINE1/CD68/IL6/SNAI2/SBNO2/ITGA2/PPBP/MIR125B1/KDM5D/IRAK2/ARNTL/ATP1A1/LRP8/ASS1/CXCL1/CEBPB/FBXO32/NFKBIA/TNIP2/ZFP36L2/TEAD2/TFPI/PDK4/PIM1/CXCL3/NME1/AKR1C3/TNFAIP3/ABL2/AKR1C1/ZNF703/NKX3-1/MSN/ZFP36L1/VDR/ICAM1/MYD88/PPP1R9B/KLF9/DAB2/CD40/NR1D1/RELA/PPARD/HAVCR2/IRAK1/LBP/LITAF/ZMIZ1/ZC3H12A/BCL10/NFKBIB/NOD2/INHBA/AKAP8/ZFP36/HCK/TRIB1/NFKB1/DAXX/PHB2/CLU/SIRPA/DDRGK1/NCOA3/AKT1/CDK19/CXCL6/PHB/LYN GOBP_MONONUCLEAR_CELL_DIFFERENTIATION 1.357956787 0.005162764 0.049010788 VEGFA/MT1G/PNP/IL6/BCL6/SOX4/MMP14/MYC/RELB/MIR125B1/BCL3/MAFB/ST3GAL1/CEBPB/TNFSF8/IL4R/ZFP36L2/DNAJB9/NFKBIZ/CLCF1/SLAMF8/PTPN2/CTSL/STAT3/IFI16/LRRC8A/ZFP36L1/SMAD7/PDE1B/ZBTB7B/FADD/RARA/SOS1/IL18R1/LOXL3/ZMIZ1/ZC3H12A/SASH3/ATP11C/IL1RL2/INHBA/FZD5/CSF1/ADAM17/JAK3/LTBR/PRELID1/BATF/ENTPD7/FCER1G/IFNE/NHEJ1/DCLRE1C/LYN/CBFB/ZBTB16/XBP1/BTK/BATF2/BAK1/F2RL1/PREX1 GOBP_REGULATION_OF_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY 1.363608466 0.003571208 0.038351933 VEGFA/HMOX1/TLR2/FOSL1/IL6/S100A9/TRAF1/BHLHE40/IL1RAP/IRAK2/LRP8/CYP1B1/NFKBIA/PIM1/HIPK2/FLOT2/TNFAIP3/STAT3/FLOT1/NKX3-1/RIPK4/MAD2L2/S100A8/RPS3/BUD31/ICAM1/SMAD7/MYD88/PTEN/CD40/RELA/HAVCR2/IRAK1/NFKB2/AGT/IL18R1/SAV1/PPRC1/MAP3K13/IRAK3/ZC3H12A/BCL10/NDP/NFKBIB/NOD2/NLRC4/SUMO1/SPHK1/PSMA6/CIB1/CRTC2/TRAF3/HCK/TRIB1/MIR30C2/SMAD3/TFRC/DDIT3/NFKB1/PHB2/CLU/TRADD/DDRGK1/NUPR1/TRIM8/S100A12/AKT1/NFKBIE/MAVS/MIR125A/TNFRSF11A/HCLS1/TAF3/BTK/TAB3/SMARCA4/HSPA1B/ARID5B/WNT2/SP100/RIPK1/MIR26A1/TRIM27/BRMS1/PRKD1/DHX33/MIR27A/STK3/ADAM8/G3BP2/HDAC2/TRIM22/MEN1/UBB/UBC/HEYL/MIRLET7E/PELI1/EZH2/ITGB2/ARHGEF2/CACTIN/CLOCK/RLIM/ZBTB7A GOBP_LEUKOCYTE_DIFFERENTIATION 1.359003854 0.002881792 0.032854884 VEGFA/TLR2/MT1G/LIF/PNP/IL6/BCL6/SBNO2/SOX4/UBASH3B/MMP14/MYC/RELB/MIR125B1/BCL3/MAFB/ST3GAL1/CEBPB/TNFSF8/IL4R/ZFP36L2/DNAJB9/NFKBIZ/CLCF1/SLAMF8/PTPN2/CTSL/NME1/CCR1/CARTPT/STAT3/IFI16/LRRC8A/ZFP36L1/SMAD7/JAGN1/PDE1B/ZBTB7B/TYROBP/FADD/RARA/SOS1/TFE3/IL18R1/LOXL3/ZMIZ1/ZC3H12A/SASH3/ATP11C/IL1RL2/INHBA/FZD5/CSF1/ADAM17/JAK3/FBN1/LTBR/TRIB1/PRELID1/TFRC/BATF/ENTPD7/SLC9B2/LILRB3/FCER1G/L3MBTL3/IFNE/NHEJ1/DCLRE1C/LYN/TNFRSF11A/HCLS1/CBFB/ZBTB16/XBP1/SRC/BTK/BATF2/BAK1/F2RL1/CDC42/PREX1/JUNB/SH3PXD2A/RORA/NME2/RIPK1/EGR1/GPR137 GOBP_METAL_ION_HOMEOSTASIS -1.306468278 0.005158014 0.049010788 CCL8/CCL13/ISCU/KCNJ2/AGTR2/ATP2B1/BCL2/GSTM2/S1PR1/CD24/GATA2/KL/SLC25A23/P2RY10/TF/GPR174/SLC39A13/F2RL2/MICU3/GPR4/EXT1/FAM155B/GPR20/TACR1/MCOLN3/CNNM2/NPPB/CALB2/CALM2/PKD1/PIK3CG/GPER1/CXCL11/BOK/RIC3/SLC39A10/JAK2/SNCA/NPTN/PLCG2/WNT5A/NEO1/CCDC115/SLC40A1/CSRP3/CYBRD1/CCL5/TRPC1/NCS1/HFE/RYR2/SLC12A4/ATP1B1/CXCL10/SMDT1/ADCY5/STC1/CASQ1/HRC/ESR1/ADRA1D/PTGER4/CYSLTR1/TNNI3/HYAL2/JPH2/ADRA1B/TRPC6/RYR3/ATP1A2/CAV1/EDNRB/LPAR4/CALM1/CCL3/DMD/EDN1/DMPK/WFS1/CAV2/KCNMA1/NPR1/ATP1B2/AGTR1/PKD2/GRIN2A/SLC8A1/THY1/AVPR1A/CLIC2/PTGFR/CXCL9/CCL19/BMP6/PLN/CD55/GRIA1/SLC24A4/ACKR3/ABCG2/SCN7A/CX3CR1/CDH5/ACKR4/CASQ2/RAMP3/SCARA5/APLNR/CCL21/C7 GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION -1.321023692 0.002538847 0.030300481 CMTM5/SEMA5A/PRDM6/CHRD/INSIG1/TRIM6/ERBB2/SIRT2/DAAM2/TGFBR1/TNN/FGF9/SOCS1/CDK6/CCL11/MIR181B1/MIR103A1/MIXL1/NMRK2/ZFPM2/INPP5D/CHADL/TCTA/SOX8/MBNL3/ISL1/ITPKB/GATA2/SKIL/NELFB/MAPK1/POSTN/COL5A1/BAMBI/MCF2/PKP2/RARG/SEMA3B/SOX9/CNTN4/RORB/ADAMTS7/SEMA3E/TLR4/VASN/NOTCH1/TAL1/GPER1/ID3/CCND1/RUNX1T1/WNT5A/ZBTB46/HOXA2/HDAC5/HEY1/TWIST2/FSTL3/PTN/BHLHE41/RANBP3L/SEMA6A/EPHA7/CXCL10/BMP4/TBX5/TOB1/SEMA3A/IL17RD/TWSG1/GDF10/TMEM176A/P2RY12/FST/BDNF/NFATC2/PDGFB/SORL1/TRPC6/TMEM176B/SOX10/TGFB1I1/CD74/CAV1/EDNRB/PRICKLE1/NOTCH4/MAP2/OSR1/RARB/SORT1/CCL3/PPARG/HEY2/FGF10/FZD7/SEMA3C/RBPMS2/FRZB/FGL2/THY1/ACTN4/TMEM119/HAND2/SEMA3D/LRRC17/SFRP1/TGFB2/IGF1/FBLN1/CRIM1/MIR100/THRB/NRARP/ADIPOQ/SEMA3G/SFRP2/IGF2/PI16/CXCL14 GOBP_REGULATION_OF_CYTOSKELETON_ORGANIZATION -1.34978643 0.002818377 0.032393105 RHOBTB2/DIXDC1/RICTOR/ARHGEF10/DMTN/CHMP5/CORO2B/INPP5K/SVIL/CTTN/FES/SEMA5A/LIMCH1/TGFBR1/SKA2/RASSF1/PLXNB1/CAPN2/GPM6B/HDAC6/MAP1B/MAP1A/CGNL1/STMN2/CCL11/ARPIN/CD47/EPHA5/MDM1/GNAI1/MYO1C/SORBS3/MYLK3/ROCK2/TMSB4X/S1PR1/ARPC1A/GMFG/KATNBL1/LMOD3/PICK1/MAPK1/CCDC88A/F11R/RND2/SEMA3E/PKD1/ADD3/LIMA1/PROX1/SYNPO2L/KANK4/DAPK3/SYNPO2/SNCA/MYADM/SPTAN1/ESAM/SPTBN1/PTK2/KAT2B/PAM/WNT11/CDC42EP2/KANK3/ARHGEF10L/LMOD1/DLC1/CLASP2/SHANK3/FHOD3/LMOD2/NES/CFL2/PTGER4/PFN2/BST1/FSCN1/ASAP3/MAP2/PAK3/TRIM36/SLIT2/EDN1/PPP1R9A/EPHA3/FLNA/ELN/TMOD2/DSTN/CAPN6/RHOBTB1/FRMD7/NEXN/SFRP1/ARHGEF15/TPM1/MYOC/FAM107A/ACTN2/TEK/CDH5/RGCC/CCL21 GOBP_RESPONSE_TO_PEPTIDE -1.362577725 0.002164969 0.027642251 GNAI1/MYO1C/AGTR2/KLF15/ATP2B1/ROCK2/ZNF106/KL/C2CD5/CPEB2/PIK3R3/ADCY2/PCK1/LPIN3/INSR/ACVR1C/GPR21/TLR4/NOTCH1/GNRH1/PID1/GPER1/JAK2/ADCY9/INHBB/STAT4/PTK2/KAT2B/LEP/QDPR/CSRP3/VIM/HDAC5/JUND/ADCY5/GSTP1/CYBB/ADRB2/ADCY1/ATP6V1C2/KLF11/SORL1/CAV1/EDNRB/SLC2A4/ADCY4/SORT1/ATP6V0E2/SPARC/PPARG/EDN1/TBC1D4/CAV2/KLF4/LDOC1/RARRES2/HHEX/AGTR1/MIR145/NR4A3/PRKAR2B/MGARP/GPLD1/PLN/EGR2/IGF1/TNFSF10/NR4A2/ACTN2/NR4A1/TEK/MIR140/ADIPOQ/KLF2/LPL/RAMP3/FABP3/IGF2/SERPINF1 GOBP_DIVALENT_INORGANIC_CATION_HOMEOSTASIS -1.350666145 0.004089591 0.041482998 CCL8/CCL13/ATP2B1/BCL2/GSTM2/S1PR1/CD24/GATA2/KL/SLC25A23/P2RY10/GPR174/SLC39A13/F2RL2/MICU3/GPR4/FAM155B/GPR20/TACR1/MCOLN3/CNNM2/CALB2/CALM2/PKD1/PIK3CG/GPER1/CXCL11/BOK/RIC3/SLC39A10/JAK2/SNCA/NPTN/PLCG2/WNT5A/CSRP3/CCL5/TRPC1/NCS1/RYR2/ATP1B1/CXCL10/SMDT1/ADCY5/STC1/CASQ1/HRC/ESR1/ADRA1D/PTGER4/CYSLTR1/TNNI3/JPH2/ADRA1B/TRPC6/RYR3/ATP1A2/CAV1/EDNRB/LPAR4/CALM1/CCL3/DMD/EDN1/DMPK/WFS1/CAV2/AGTR1/PKD2/GRIN2A/SLC8A1/THY1/AVPR1A/CLIC2/PTGFR/CXCL9/CCL19/PLN/CD55/GRIA1/SLC24A4/ACKR3/CX3CR1/CDH5/ACKR4/CASQ2/RAMP3/APLNR/CCL21 GOCC_CELL_SUBSTRATE_JUNCTION -1.363872661 0.003845733 0.039987906 CNN3/TRIP6/CD81/SLC9A3R2/LIMA1/L1CAM/SYNPO2/JAK2/PTK2/ZNF185/JUP/TES/VIM/CASK/ZFYVE21/FZD2/HSPG2/NRAP/FHL2/DLC1/EPB41L2/AJUBA/CLASP2/FAT1/AHNAK/AIF1L/FLNB/IL16/KLF11/CD9/RRAS/ILK/TGFB1I1/ITGA8/CAV1/ASAP3/EFNB2/DPP4/DMD/CNN2/SCARF2/ITGB8/CAV2/ITGBL1/FLNA/MCAM/LIMS2/THY1/ACTN4/PGM5/CSRP1/PDLIM7/SORBS2/THSD1/EHD3/NEXN/CDH2/FHL1/CNN1/FLT1/FAM107A/ACTN2/TEK/SMPX/ITGB4/ITGA6/ACTC1 GOCC_POSTSYNAPSE -1.393714288 0.000979979 0.01531033 KCND2/DMTN/ARHGAP33/PRR12/TIAM1/ABHD17B/CTTN/IQSEC1/INPP4A/ARF4/DNM1/CPEB1/SRI/C1QA/CLSTN1/RNF19A/SNAP25/MAP1B/EPS15/RAB4A/CHRNE/ERBB4/EEF2K/IGSF11/CNKSR2/OPHN1/CLSTN2/DRP2/PDLIM5/RGS9/KCNJ2/ATP2B1/KCNB1/CDKL5/IGSF9B/GRIP1/GLRB/PICK1/MAPK1/NSMF/SLITRK3/FLRT3/PLEKHA5/KCTD12/SNTA1/LIN7B/PCLO/CBLN1/CNN3/NLGN4X/GABRA4/SLITRK1/ADD3/GRIK3/GPER1/CD3E/KCNA4/JAK2/NPTN/LRRK2/GABRB1/WNT5A/PTK2/KCNA3/NLGN3/CNTN1/LRRC4B/ARHGEF9/CTTNBP2/PTN/PSD3/NCS1/ARRB1/RUSC1/EPHA7/SH3GL3/SHANK3/ADCY1/CRYAB/ZDHHC2/PLCB1/PALM/ATP1A2/ITGA8/SYNE1/PAK3/GPM6A/MEF2C/DMD/PRRT2/DCLK1/KCNMA1/PPP1R9A/FLNA/ADAM22/GRIN2A/SHC4/SLC8A1/PRKAR2B/CAP2/AKAP5/PLCB4/GRIA2/PCDH17/CDH2/GRIA1/RGS7BP/NTRK2/ACTN2/PALMD/GSG1L GOBP_PEPTIDYL_TYROSINE_MODIFICATION -1.359091474 0.005104853 0.048758793 MAP2K6/CD81/TAL1/PDGFC/CD3E/FGF7/JAK2/PTK2/FLT4/LEP/CNTN1/CCL5/FGFR2/WEE1/EPHA7/PDGFD/ADRA2A/ACE/HYAL2/ERBB3/BDNF/PDGFB/BST1/CD74/CAV1/PKDCC/EPHB4/FGF10/EPHA3/HBEGF/ANGPT1/RELN/THY1/TTN/AFAP1L2/GAS6/BMP6/TIE1/SFRP1/IGF1/GPRC5B/THBS4/IL31RA/NTRK2/FLT1/BTC/TEK/ADIPOQ/KDR/SFRP2/IGF2/PECAM1 GOBP_EPITHELIAL_CELL_DIFFERENTIATION -1.406325595 0.000662676 0.011607095 KIAA1109/CCDC88C/SIX1/SOX8/KLF15/ROCK2/EPB41L5/RAPGEF1/S1PR1/CD24/GSTA1/SKIL/GPR4/VCL/PCK1/NR5A2/GSTK1/EXT1/PKP2/MCOLN3/CPT1A/RARG/BFSP1/F11R/SOX9/DHRS9/THRA/CNN3/NOTCH1/PROX1/ATOH8/ID3/CCND1/MYADM/TAGLN/WNT5A/DSC3/JUP/AR/PDE2A/VIM/HEY1/PTN/WNT11/FZD2/FGFR2/SCUBE1/MAF/BMP4/STC1/JAG2/CLDN1/ESR1/DSG2/ASAH1/CYP26B1/CD109/PDGFB/PLCB1/SOX17/TGFB1I1/CAV1/SPINT2/NOTCH4/FOXC1/SCX/OSR1/RARB/FSTL1/MEF2C/CES1/TMEM100/PPARG/HEY2/FGF10/PRKCH/KLF4/SOX18/ACVRL1/FZD7/FLNA/FRZB/HEG1/DSP/ROBO4/PGR/BMP6/TIE1/CDH2/CTSK/COL15A1/CD34/IL31RA/PPP1R16B/THRB/PROM1/ADIPOQ/KLF2/ACTA2/CDH5/KDR/PODXL/SFRP4/PECAM1 GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS -1.433094188 0.000200022 0.005020392 SGK1/NR3C1/CRY1/PRCP/EEF2K/MIR103A1/DNMT3B/MZB1/MYO1C/PAGR1/AGTR2/ATP2B1/ROCK2/ZNF106/ISL1/KL/C2CD5/CPEB2/NSMF/PIK3R3/ADCY2/PCK1/NR5A2/PPARGC1A/PMEPA1/LPIN3/INSR/RARG/FECH/GPR21/THRA/NOTCH1/PID1/GPER1/BBS2/JAK2/NR3C2/ADCY9/RXRG/INHBB/PTK2/KAT2B/LEP/AR/CSRP3/HDAC5/HEY1/CRY2/BMP4/ADCY5/STC1/GSTP1/LGR5/ADRA2A/ESR1/ADCY1/PTGER4/ATP6V1C2/SORL1/SOX10/ATP1A2/CAV1/CTSH/SLC2A4/RARB/ADCY4/MEF2C/ATP6V0E2/SLIT2/PPARG/ZNF366/EDN1/DUSP1/TBC1D4/SLIT3/CAV2/RARRES2/GPAM/RAMP1/AGTR1/MIR145/NR4A3/PRKAR2B/MGARP/SOST/PTGFR/NR1D2/PGR/GPLD1/SFRP1/LMO3/APOB/NR4A2/FAM107A/ACTN2/FOSB/NR4A1/THRB/ADIPOQ/LPL/RAMP3/RAMP2/IGF2/FOS/SERPINF1 GOBP_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS -1.403354139 0.001570968 0.021804191 LAMA4/MDM1/IGKC/PER2/BCL2/ACOT11/S1PR1/GATA2/ACADL/CUBN/TF/PIWIL4/VCL/ADCY2/EXT1/OMA1/PPARGC1A/LAMC1/F11R/IGHG3/SOX9/THRA/TLR4/ADAMTS5/MAP2K6/BARD1/NOTCH1/NDN/PDGFC/AZGP1/BBS2/JAK2/ADCY9/CIDEA/ESAM/LEP/SCD/SLC40A1/PM20D1/ADCY5/NOVA2/METRNL/CLDN1/STK39/HADH/ADRB2/ADCY1/HYAL2/CYP26B1/RBP4/SLN/CAV1/EDNRB/CTSH/FOXC1/TNFRSF11B/SCX/ADCY4/MYO5B/DMD/NOS3/ABCA3/WFS1/GATM/ATP1B2/ANGPT1/MRAP2/NR4A3/PRKAR2B/ACACB/NR1D2/TMEM119/EBF2/BMP6/CD34/NPR3/IGHA1/PROM1/IGHA2/ALDH1A1/ADIPOQ/CDH5/ADGRF5/CYTL1/LDB2/JCHAIN/PECAM1/FABP4 GOBP_EPITHELIAL_CELL_PROLIFERATION -1.38456774 0.002968365 0.033594075 ERBB2/TGFBR1/FGF9/NR2F2/MCC/IFT172/CDK6/CCL11/MIR181B1/RGN/ANG/MIR101-1/PTPRM/MIR23A/VASH1/SIX1/COL8A2/ISL1/GATA2/COL4A3/NLRC3/FERMT1/MAPK1/PLXNB3/CDKN2B/LAMC1/HYAL1/SOX9/MIR30E/TLR4/ALDH1A2/NOTCH1/PROX1/ATOH8/FGF7/VEGFB/CCND1/FUT1/WNT5A/FLT4/LEP/AR/CASK/OSR2/PTN/FGFR2/BMP4/HTRA1/LGR5/CLDN1/MIR410/ESR1/FST/CD109/PDGFB/CAV1/EDNRB/F3/OSR1/MEF2C/SPARC/PPARG/FGF10/CAV2/ACVRL1/FZD7/DLL4/CDKN1C/AGTR1/NR4A3/LIMS2/PGR/BMP6/TIE1/SFRP1/CD34/TGFB2/EGFL7/IGF1/THBS4/SCG2/FLT1/PPP1R16B/NR4A1/TEK/NRARP/GPC3/KDR/SFRP2/RGCC/APLNR/IGF2/SERPINF1 GOCC_AXON -1.440697268 0.000241066 0.00569942 DNM1/ACTR10/MAP2K4/SRI/GDPD5/SIRT2/TNN/SNAP25/HDAC6/ROR1/DCTN2/MAP1B/MAP1A/SLC2A13/STMN2/ANG/MME/OPHN1/EMB/EPHA5/IGHMBP2/MYPN/KCNB1/LAMP5/CDKL5/SACS/COPG2/MAPK1/FLRT3/TIMP2/INSR/NGEF/FEZ1/BOC/CNTN4/PLEKHG5/CALB2/PCLO/UNC5C/GNRH1/GRIK3/GPER1/L1CAM/APBB2/MAP4/KCNA4/BAG2/SNCA/NPTN/LRRK2/ADCY9/SPTBN1/KCNA3/PSEN2/LRRC4B/NCS1/SEMA6A/NMNAT2/ADGRL3/UNC13C/EXOC6/NDRG2/SCN3A/KCNAB1/MYO1D/SEMA3A/CDH8/CRYAB/OLFM1/BDNF/PALM/SCN9A/SH2D3C/FSCN1/MAP2/CALM1/MYOT/GPM6A/PRRT2/PPP1R9A/FLNA/ADAM22/SLC8A1/THY1/MGARP/ROBO4/TMOD2/FRMD7/NEXN/TGFB2/GRIA1/IL31RA/NTRK2/MYOC/SCN7A/ANXA3/SERPINF1 GOBP_GLYCEROLIPID_METABOLIC_PROCESS -1.397862492 0.002111048 0.027290008 CAPN2/SOCS1/GDPD1/RAB4A/RGN/ANG/TAZ/CAT/CNEP1R1/INPP5D/MTM1/ITPKB/BPNT1/BMX/MPPE1/PLCD1/DDHD2/PNPLA4/PIK3R3/PCK1/PIGZ/LPIN3/CPT1A/SERAC1/PLA1A/INPP4B/PCYT2/AGPAT2/PNPLA7/LPCAT4/PIK3CG/LIPE/PLD1/PIGK/PLCG2/CDS2/PTPN13/MTMR11/DGKG/PLBD1/NAAA/THRSP/SLC44A3/AJUBA/MBOAT1/CHKB/PIK3C2B/LCAT/PNPLA2/PDGFB/PLCB1/SORL1/DPM3/CAV1/INPP5A/MGLL/ABCA3/GPAM/MTTP/GPD1L/GPD1/GPLD1/APOB/LPL/FABP3/PLA2G2A/C3/FABP4 GOBP_SYNAPTIC_SIGNALING -1.450459161 0.000185927 0.004857538 SCN2B/SYPL1/CLSTN1/RNF19A/SNAP25/CADPS2/CACNB4/MAP1B/MAP1A/CHRNE/SYNGR1/HTR1F/MME/IGSF11/OPHN1/PCDHB4/CLSTN2/DRP2/GNAI1/KCNB1/ROR2/GLRB/PICK1/MAPK1/NSMF/EXT1/KCNMB1/AMPH/TMEM25/USP46/AGRN/CNTN4/LIN7B/CALB2/PCLO/GJC1/CBLN1/NLGN4X/MCTP1/GABRA4/GPR176/GRIK3/GPER1/RIC3/JAK2/SNCA/NPTN/LRRK2/GABRB1/NLGN3/KCNMB4/CASK/PTN/LGI1/NCS1/ADARB1/SLC12A4/NAAA/SLC1A4/UNC13C/SHANK3/RIMS3/DOC2B/CDH8/ADRA2A/PTPRD/ADRB2/ADCY1/KCNIP2/PLK2/ZDHHC2/BDNF/PLCB1/NPTXR/FGF12/ATP1A2/COLQ/GLS/CALM1/MEF2C/RIMS4/NPY5R/EDN1/DMPK/PRRT2/BCHE/PPP1R9A/RELN/GRIN2A/PRKAR2B/AKAP5/TMOD2/PLCB4/GRIA2/PCDH17/CDH2/EGR2/GRIA1/PLP1/NTRK2/FAM107A/MPZ/ADIPOQ/CX3CR1 GOMF_RECEPTOR_REGULATOR_ACTIVITY -1.39195155 0.003231276 0.035814751 CTF1/FGF18/CXCL2/THNSL2/SEMA3B/NPPB/XCL2/SEMA3E/GNRH1/CXCL11/PXDN/PDGFC/FGF7/VEGFB/CLEC12A/INHBB/WNT5A/LEP/CMTM3/CCL5/PTN/WNT11/CDC42EP2/SEMA6A/EPHA7/CXCL10/CLEC11A/BMP4/STC1/PDGFD/JAG2/METRNL/SEMA3A/DKK2/GDF10/IL16/FST/DKK3/BDNF/CCL3L3/PDGFB/FGF12/TNFRSF11B/DPP4/CCL3/EDN1/C1QTNF9/FGF10/SEMA3C/HBEGF/MRAP2/FNDC5/CXCL9/CCL19/GAS6/BMP6/SEMA3D/NPPA/TGFB2/IGF1/THBS4/TNFSF10/SCG2/BTC/LEFTY2/OGN/ADIPOQ/SEMA3G/SFRP2/IGF2/CCL21/CXCL14 GOBP_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION -1.394706288 0.003345787 0.036626947 RICTOR/ARHGEF10/DMTN/CORO2B/INPP5K/SVIL/CTTN/FES/SEMA5A/LIMCH1/TGFBR1/HDAC6/MAP1B/MAP1A/CGNL1/STMN2/CCL11/ARPIN/CD47/EFEMP2/CHADL/MYO1C/SORBS3/MYLK3/ROCK2/TMSB4X/S1PR1/ARPC1A/GMFG/LMOD3/PICK1/CCDC88A/F11R/ADD3/LIMA1/PROX1/SYNPO2L/KANK4/DAPK3/SYNPO2/SNCA/MYADM/SPTAN1/ESAM/SPTBN1/WNT11/CDC42EP2/KANK3/ARHGEF10L/LMOD1/DLC1/CLASP2/SHANK3/FHOD3/LMOD2/CFL2/CRYAB/PTGER4/PFN2/ASAP3/MAP2/PAK3/SLIT2/EDN1/PPP1R9A/FLNA/ELN/TMOD2/DSTN/FRMD7/SFRP1/ARHGEF15/TPM1/MYOC/ACTN2/CDH5/RGCC/CCL21 GOBP_MAINTENANCE_OF_LOCATION -1.374531928 0.005147619 0.049010788 GSTM2/TMSB4X/FBN2/SLC25A23/GM2A/ARL2BP/ALKBH7/VPS13A/CCDC88A/EHD1/ARHGAP21/ACVR1C/MCOLN3/CPT1A/CALM2/MDFI/BARD1/PKD1/GPER1/CXCL11/SNCA/PLCG2/CDS2/SUN1/CIDEA/SREBF2/LEP/TRPC1/RYR2/CXCL10/CASQ1/HRC/PNPLA2/JPH2/TMEM159/SORL1/RYR3/ATP1A2/CAV1/SYNE1/CALM1/KDELR3/CCL3/CES1/PPARG/DMD/FLNA/PKD2/SLC8A1/THY1/CLIC2/ACACB/CXCL9/CCL19/PLN/APOB/LTBP1/LPL/CASQ2/APLNR/CCL21/C3 GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY -1.402344484 0.002971493 0.033594075 CCDC88C/KLF15/RAPGEF1/VGLL4/ISL1/ROR2/FERMT1/BAMBI/ALPK2/MDFIC/SOX9/TMEM237/MDFI/NOTCH1/DAPK3/LRRK2/WWOX/RSPO1/PPM1B/TBL1X/WNT5A/JUP/TMEM170B/LGR6/WNT11/FGFR2/RSPO2/CTNNBIP1/LGR5/FZD6/DKK2/ESR1/FZD4/ATP6V1C2/DKK3/NXN/SOX10/SOX17/ILK/CAV1/CXXC4/PRICKLE1/ADGRA2/FGF10/FZD7/HHEX/DACT1/RSPO3/FRZB/MIR145/SOST/TMEM88/SOX7/SFRP1/CDH2/NKD1/GPRC5B/IGFBP6/ANKRD6/CTHRC1/NRARP/GPC3/SFRP2/SFRP4 GOCC_DENDRITIC_TREE -1.463510002 0.000113307 0.003453649 TIAM1/ABHD17B/CTTN/DMWD/ARF4/DNM1/CPEB1/MAP2K4/SRI/KCNB2/TNN/CLSTN1/CAPN2/HDAC6/ADA/MAP1B/MAP1A/TMEM185A/SGCE/HTR1F/MME/EEF2K/OPHN1/BMPR1B/CLSTN2/EPHA5/DRP2/KCNJ2/ATP2B1/KCNB1/LAMP5/CDKL5/ROR2/GRIP1/GLRB/SACS/MARK1/MAPK1/NSMF/GRK4/ADCY2/PPARGC1A/INSR/FEZ1/EPHB3/CALB2/CNN3/NLGN4X/UNC5C/GABRA4/BRINP3/GNRH1/GRIK3/GPER1/L1CAM/CD3E/KCNA4/BAG2/NPTN/LRRK2/DNER/ADCY9/GABRB1/PTK2/PSEN2/CTTNBP2/NCS1/ARRB1/SAMD4A/EPHA7/SLC1A4/PLXDC1/SHANK3/KCNAB1/MYO1D/SEMA3A/TTLL7/CYBB/CRYAB/FZD4/PLK2/RBM3/BDNF/PALM/ATP1A2/ITGA8/MAP2/INPP5A/GPM6A/ADCY4/SORT1/PRRT2/WFS1/PPP1R9A/FLNA/RELN/GRIN2A/SLC8A1/PRKAR2B/THY1/AKAP5/CKB/PLCB4/GRIA2/ARHGEF15/GRIA1/NTRK2/ACTN2/PALMD/CX3CR1/ANXA3/APOD GOBP_DEVELOPMENTAL_GROWTH -1.466975227 0.000117382 0.003526004 SEMA5A/CPNE5/MAP2K4/MAPK11/NDRG4/CDKN1B/LAMB2/TGFBR1/FOXS1/TNN/IMPACT/HDAC6/ADRB1/MAP1B/EVC/CCL11/EZR/ERBB4/HESX1/ZFPM2/ENO3/MIR23A/BMPR1B/PDLIM5/SYT17/AGTR2/SIX1/BCL2/EPB41L5/CDKL5/VGLL4/MTM1/S1PR1/TBX20/RNF157/MUSTN1/MAPK1/POSTN/VCL/MIR17HG/FLRT3/EXT1/THBS3/MYOZ1/SOX15/WWC3/INSR/ACVR1C/COMP/RARG/AGRN/RND2/SEMA3B/SOX9/GPR21/SEMA3E/NLGN4X/CD81/NOTCH1/SLITRK1/NDN/PROX1/L1CAM/CPQ/FGF7/BBS2/WNT5A/NLGN3/LEP/PLXNA1/AR/BNC2/GAS1/LGR6/PTN/WNT11/FGFR2/ADARB1/SEMA6A/RSPO2/EPHA7/BMP4/STC1/SHANK3/TBX5/SEMA3A/ADRB2/ESR1/OLFM1/BDNF/RBP4/PLCB1/CD9/SOX10/ZMPSTE24/MAP2/FOXC1/RARB/MEF2C/PKDCC/SLIT2/MYH6/HEY2/EDN1/CRABP2/FGF10/SLIT3/DCLK1/FZD7/GPAM/SEMA3C/HEG1/ACACB/SORBS2/SEMA3D/SFRP1/NKD1/TGFB2/IGF1/NPY1R/KLF2/SEMA3G/SFRP2/IGF2/PI16/APOD GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY -1.396105717 0.003703548 0.039365235 IGLV3-25/IGKV1D-33/CD96/RASGRP1/CD1E/SH2D1A/RIPK3/IGHV3-72/IGLV1-47/C1QA/BTN3A2/IGHV3-48/HLA-B/INPP5D/IGHV3-21/IGLV1-40/IGKC/IGHV3-30/IGKV1-12/CD40LG/TRDC/CD8A/IGHV1-18/IGLV3-19/RAET1E/TREX1/IGHV3-49/CADM1/MSH2/IGHG3/STX7/IGKV2-30/LYST/CD81/IGHV3-11/IGLC6/AZGP1/NLRP3/BTN3A3/LEP/HFE/DENND1B/IGKV1-5/IGHV3-33/IGLV2-14/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/HLA-DQB1/RSAD2/CD74/IGHV3-23/CTSH/IGKV3-20/CD1C/IGHM/IGHV3-7/HLA-DRA/RFTN1/IGHG1/HLA-DRB1/CD55/C6/IGHG2/IGHA1/IGHA2/CFI/C3/C7 GOBP_CELL_CELL_SIGNALING_BY_WNT -1.482585087 0.000183519 0.004838736 APCDD1/RPS27A/SFRP5/TIAM1/CALCOCO1/TNRC6A/JRK/GPC5/ZBED3/VANGL1/WNK2/MITF/SEMA5A/TBL1XR1/DAAM2/TNN/CCNY/MCC/ROR1/GRK5/SKP1/FZD1/HESX1/VANGL2/CCDC88C/KLF15/RAPGEF1/GPC6/VGLL4/ISL1/CD24/ROR2/MARK1/FERMT1/BAMBI/EXT1/ALPK2/MDFIC/RARG/SOX9/TMEM237/MDFI/DAAM1/PKD1/NOTCH1/DAPK3/LRRK2/WWOX/PLCG2/CCND1/RSPO1/PPM1B/TBL1X/WNT5A/JUP/TMEM170B/LGR6/WNT11/FZD2/AGO4/FGFR2/RSPO2/CTNNBIP1/NDRG2/LGR5/FZD6/DKK2/FZD8/ESR1/FZD4/ATP6V1C2/DKK3/PLCB1/NXN/SOX10/SOX17/ILK/TGFB1I1/CAV1/CXXC4/PRICKLE1/CALM1/ADGRA2/FGF10/KLF4/FZD7/HHEX/DACT1/RSPO3/PKD2/FRZB/MIR145/SOST/TSPAN12/TMEM88/SOX7/SFRP1/CDH2/NKD1/GPRC5B/NR4A2/IGFBP6/ANKRD6/AMOTL2/CTHRC1/MYOC/NRARP/GPC3/SFRP2/SFRP4 GOCC_CELL_LEADING_EDGE -1.457404939 0.00094305 0.014827659 MCC/HDAC6/STMN2/SGCE/CDK6/EZR/ARPIN/FRMD4B/PTPRM/MYO1C/CYTH3/ATP2B1/KCNB1/EPB41L5/LAMP5/CDKL5/MTM1/BMX/C2CD5/ABI3/FGD6/FERMT1/CCDC88A/AMPH/ARHGEF4/INSR/EPS8L2/LMO4/PLEKHG5/TLR4/UNC5C/GABRA4/GPER1/LIMA1/APBB2/MYADM/SPTBN1/PTPN13/VIM/PSD3/RASGRP2/MYLK/DLC1/AJUBA/CLASP2/MYO1D/AIF1L/CTNNA3/PALM/ILK/KLHL41/ITGA8/SH2D3C/FSCN1/ASAP3/DPP4/ACTG2/PPP1R9A/S100B/PKD2/THY1/ABLIM1/AKAP5/FGD5/PDLIM7/SORBS2/CDH2/GRIA1/TPM1/FAM107A/ITGB4/ACTA2/LDB2/MYH10/ACTC1/PODXL GOCC_GLUTAMATERGIC_SYNAPSE -1.418030349 0.002485857 0.030013701 CLSTN1/RNF19A/SNAP25/CADPS2/EPS15/ERBB4/CNKSR2/OPHN1/CLSTN2/DRP2/RGS9/ATP2B1/CDKL5/GPC6/GRIP1/FLRT3/PLEKHA5/USP46/PCLO/CBLN1/NLGN4X/SLITRK1/GRIK3/JAK2/NPTN/LRRK2/WNT5A/KCNA3/NLGN3/LRRC4B/CTTNBP2/LGI1/NCS1/EPHA7/ADGRL3/SH3GL3/CDH8/PTPRD/ADCY1/FZD4/PLCB1/NPTXR/SPARCL1/PAK3/GPM6A/EFNB2/SPARC/PPM1H/PPP1R9A/FLNA/ADAM22/GRIN2A/PRKAR2B/PLCB4/PCDH17/GRIA1/RGS7BP/ACTN2/GSG1L GOBP_EPITHELIAL_TUBE_MORPHOGENESIS -1.427593351 0.003738487 0.039466747 VANGL2/AGTR2/SIX1/SOX8/BCL2/TBX20/IRX1/EXT1/STARD13/RARG/LMO4/SOX9/SEMA3E/PKD1/NOTCH1/NPNT/PROX1/LAMA5/WNT5A/AR/KLHL3/WNT11/FZD2/FGFR2/RYR2/RSPO2/EPHA7/CXCL10/BMP4/DLC1/CTNNBIP1/TCAP/LGR5/FZD6/ESR1/SOX17/SPINT2/CTSH/PRICKLE1/NOTCH4/OSR1/MEF2C/SLIT2/EDN1/FGF10/SOX18/ACVRL1/DLL4/PKD2/RASIP1/PGR/HAND2/TIE1/SFRP1/TGFB2/CTHRC1/NRARP/GPC3/KDR/SFRP2/PODXL GOBP_FATTY_ACID_METABOLIC_PROCESS -1.457726754 0.0007999 0.013193037 ELOVL2/NUDT7/ACAT2/ACOX3/RGN/CYP2J2/TYRP1/SLC27A6/PRKAG2/ECHS1/ACSM5/PER2/ELOVL4/GSTM2/ACOT11/AIG1/GSTA1/ACADL/CYP2U1/ALKBH7/TREX1/EPHX1/PCK1/PPARGC1A/PECR/LPIN3/CPT1A/THNSL2/MIR766/SOX9/HACD4/HPGDS/LEP/SCD/PAM/FADS2/ACSL5/PM20D1/TECRL/NAAA/ABCD2/PDP1/ACAT1/GSTP1/PCCB/HADH/GPX4/ASAH1/CD74/CAV1/CES1/PPARG/MGLL/EDN1/ELOVL7/GPAM/NR4A3/PRKAR2B/AVPR1A/HACD1/ACACB/PLP1/ADIPOQ/LPL/PTGDS/FABP3/C3 GOBP_EMBRYONIC_MORPHOGENESIS -1.502246311 0.000136352 0.003925165 VANGL2/SIX1/SOX8/ROCK2/EPB41L5/FBN2/TBX20/ROR2/GATA2/HOXB2/IRX1/MAPK1/ITGB5/COL5A1/FLRT3/EXT1/KCNQ4/RARG/LMO4/HYAL1/SOX9/MDFI/ALDH1A2/NOTCH1/TAL1/PROX1/ATOH8/HOXB4/LAMA5/MYADM/WNT5A/AR/HOXA2/OSR2/ALDH1A3/WNT11/FZD2/FGFR2/RYR2/RSPO2/BMP4/DLC1/CLASP2/TCAP/TBX5/HOXB3/JAG2/DUSP4/FZD6/LRIG3/TWSG1/MMP16/CYP26B1/RBP4/SOX17/TGFB1I1/ITGA8/SPINT2/PRICKLE1/FOXC1/SCX/OSR1/RARB/MEF2C/ITGA7/EDN1/CRABP2/FGF10/DUSP1/KLF4/SOX18/FZD7/DLL4/DACT1/RSPO3/PKD2/RBPMS2/FRZB/MIR145/NR4A3/AFF3/HAND2/SOX7/COL12A1/SFRP1/TGFB2/FLT1/CTHRC1/GPC3/MFAP5/ADIPOQ/ITGB4/SFRP2/APLNR/IGF2 GOBP_POSITIVE_REGULATION_OF_LOCOMOTION -1.520135035 2.59E-05 0.001200617 BCL2/ROCK2/EPB41L5/TMSB4X/S1PR1/ROR2/GATA2/TF/SPOCK2/FERMT1/MAPK1/NSMF/POSTN/PIK3R3/RHOJ/TACR1/INSR/FGF18/BVES/SEMA3B/HYAL1/SOX9/EPB41L4B/XCL2/SEMA3E/TRIP6/PIK3CG/NOTCH1/GPER1/PROX1/ATOH8/PDGFC/DAPK3/FGF7/VEGFB/JAK2/PLCG2/TNFAIP6/F10/MYADM/FUT1/WNT5A/PTK2/FLT4/LGR6/TWIST2/CCL5/PTN/WNT11/SEMA6A/CXCL10/MYLK/BMP4/CLASP2/PDGFD/SUCNR1/CLDN1/SEMA3A/STK39/ADRA2A/PLK2/P2RY12/IL16/SMOC2/PDGFB/RRAS/CD74/CAV1/CTSH/F3/PAK3/CCL3/SLIT2/ADGRA2/SPARC/EDN1/XG/NOS3/FGF10/ATP8A1/RARRES2/SEMA3C/HBEGF/FLNA/ANGPT1/MIR145/MCAM/NR4A3/SLC8A1/THY1/ACTN4/CCL19/GPLD1/GAS6/SEMA3D/TGFB2/IGF1/PLP1/THBS4/SCG2/FLT1/ACKR3/MYOC/FAM107A/SELP/TEK/CX3CR1/ANXA3/CDH5/SEMA3G/KDR/ITGA6/PODXL/PECAM1/PLVAP/CCL21/CXCL14 GOCC_NEURON_TO_NEURON_SYNAPSE -1.448116611 0.001624387 0.022495414 LRRC4/ATP1A3/KCND2/DMTN/PRR12/TIAM1/ABHD17B/IQSEC1/INPP4A/DNM1/CPEB1/CLSTN1/RNF19A/MAP1B/ERBB4/EEF2K/IGSF11/CNKSR2/CLSTN2/DRP2/PDLIM5/RGS9/CDKL5/IGSF9B/GRIP1/PICK1/MAPK1/NSMF/SLITRK3/PLEKHA5/LIN7B/PCLO/CNN3/NLGN4X/SLITRK1/ADD3/GPER1/NPTN/NLGN3/LRRC4B/ARHGEF9/PSD3/NCS1/ARRB1/RUSC1/EPHA7/SH3GL3/SHANK3/PTPRD/ADCY1/CRYAB/ZDHHC2/PALM/ITGA8/PAK3/PRRT2/DCLK1/PPP1R9A/ATP1B2/ADAM22/GRIN2A/SLC8A1/CAP2/AKAP5/PLCB4/GRIA2/CDH2/GRIA1/RGS7BP/NTRK2/ACTN2/GSG1L GOCC_CELL_CELL_JUNCTION -1.497061041 0.0001643 0.004480789 TRIM29/CLDN5/FRMD4B/KCNA5/GJD3/IGSF11/PTPRM/FLRT2/PDLIM5/CCDC85A/CDH24/CYTH3/VANGL2/KCNJ2/EPB41L5/MAGI1/VCL/FLRT3/PKP2/CADM1/OBSL1/BVES/F11R/EPB41L4B/LIN7B/PLEKHG5/CALB2/GJC1/CNN3/NOTCH1/ADD3/PARD3B/CD3E/CCND1/MYADM/MXRA8/ESAM/WTIP/DSC3/JUP/GJA4/CASK/PARD6G/NRAP/FXYD1/ATP1B1/TSPAN33/ADGRL3/AJUBA/PLXDC1/FAT1/PCDH1/CLDN1/SYNM/AHNAK/CDH8/CDH19/FZD4/DSG2/AQP7/CTNNA3/TRPC6/ATP1A2/FSCN1/EFNB2/DPP4/CNN2/PCDH12/ARVCF/FLNA/PKD2/HEG1/SLC8A1/LIMS2/DSP/RASIP1/MPP7/PGM5/PDLIM7/HMCN1/NEXN/CDH2/TMEM47/SCN4B/AMOTL2/TEK/LDB3/CDH5/ITGA6/PODXL/DES/PECAM1 GOBP_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION -1.520113649 5.12E-05 0.001977817 PTPRS/YWHAH/CELSR2/GAB1/SLITRK2/APBB1/SLC9A6/LINGO1/ACTB/S100A6/DOK2/GLI2/KIF5B/SCN1B/SHOX2/SEMA6B/FBXW8/ZDHHC17/COBL/ARHGAP33/EPHB6/SEMA5B/CUL7/TIAM1/CTTN/SEMA5A/TMEM106B/ERBB2/GDF7/LAMB2/TNN/PLXNB1/HDAC6/MAP1B/MAP1A/MEF2A/EZR/EEF2K/PTPRM/FLRT2/OPHN1/EMB/BMPR1B/EPHA5/PDLIM5/MYPN/BCL2/CDKL5/ISL1/SKIL/MAPK1/NSMF/VCL/SLITRK3/FLRT3/MCF2/EXT1/PLXNB3/OBSL1/NGEF/FEZ1/RND2/SEMA3B/GFRA3/EPHB3/BOC/CNTN4/SEMA3E/B3GNT2/UNC5C/NOTCH1/SLITRK1/PREX2/NDN/LAMA5/L1CAM/NPTN/LRRK2/SPTAN1/ZNF365/SPTBN1/WNT5A/PTK2/NLGN3/NEO1/PLXNA1/HOXA2/LGR6/PTN/LGI1/FGFR2/ADARB1/SEMA6A/EPHA7/SHANK3/NTN4/SEMA3A/PTPRD/ADCY1/ANOS1/OLFM1/BDNF/TRPC6/MAP2/MYOT/PAK3/EFNB2/MEF2C/SLIT2/NCAM1/CRABP2/EPHB4/SLIT3/DCLK1/PPP1R9A/SEMA3C/EPHA3/S100B/CHODL/RELN/THY1/ROBO4/PDLIM7/SEMA3D/NEXN/CDH2/EGR2/NR4A2/NTRK2/GFRA1/SEMA3G GOBP_STEM_CELL_DIFFERENTIATION -1.427280631 0.003993324 0.040906896 ERBB4/FZD1/HESX1/ELL3/SOX8/ISL1/GATA2/NELFB/MAPK1/EXT1/SEMA3B/SOX9/FBXL17/SEMA3E/ALDH1A2/NOTCH1/TAL1/HOXB4/LAMA5/PTN/FGFR2/SEMA6A/BMP4/TBX5/SEMA3A/ESR1/ACE/SOX10/SOX17/EDNRB/PRICKLE1/FOXC1/OSR1/GPM6A/MEF2C/RBM24/EDN1/SOX18/SEMA3C/FRZB/SHC4/HAND2/SEMA3D/SFRP1/CDH2/TGFB2/MEOX1/SEMA3G GOCC_CELL_BODY -1.527798748 3.83E-05 0.001610074 SCN1B/ASTN2/ATP1A3/COBL/KCND2/GABARAP/MCRS1/SNPH/TIAM1/DMWD/CPNE5/MAP2K4/SRD5A1/SIRT2/KCNB2/HSPA1L/ITGA1/TNN/CAPN2/HDAC6/ADA/PGRMC1/MAP1B/MAP1A/SLC2A13/STMN2/EZR/ANG/MME/CNKSR2/BMPR1B/EPHA5/DRP2/KCNJ2/ATP2B1/KCNB1/ROR2/EEF1A2/GRIP1/RNF157/MAPK1/NSMF/GRK4/TIMP2/PPARGC1A/INSR/FEZ1/PDE1C/RDH5/CNN3/UNC5C/BRINP3/GNRH1/GRIK3/NDN/RIC3/L1CAM/CD3E/SNCA/LRRK2/SLC22A3/DNER/PTPN13/PSEN2/PAM/EPHA7/SLC1A4/PLXDC1/KCNAB1/MYO1D/TTLL7/CYBB/CRYAB/FLNB/MPL/P2RY12/OLFM1/ATP1A2/ITGA8/MAP2/MYOT/GPM6A/SORT1/TMEM100/KCNN3/ACTG2/PPP1R9A/ATP1B2/FLNA/SLC8A1/PRKAR2B/THY1/SERPINI1/CKB/FRMD7/GRIA2/NPPA/TGFB2/GRIA1/APOB/CX3CR1/ACTA2/ANXA3/ACTC1/SERPINF1/APOD GOBP_SYNAPSE_ORGANIZATION -1.504472261 0.000233748 0.005590164 ERBB2/LAMB2/C1QA/PLXNB1/CLSTN1/CACNB4/HDAC6/MAP1B/ERBB4/FZD1/EEF2K/CNKSR2/FLRT2/OPHN1/PCDHB4/CLSTN2/DRP2/PDLIM5/SIX1/CDKL5/GPC6/GLRB/SPOCK2/LRRN3/PICK1/DOK7/SLITRK3/FLRT3/IL10RA/INSR/OBSL1/SNTA1/NGEF/AGRN/EPHB3/SEMA3E/PCLO/CBLN1/NLGN4X/SLITRK1/L1CAM/APBB2/SNCA/NPTN/LRRK2/TUBA1A/DNER/ZNF365/WNT5A/NLGN3/LRRC4B/CTTNBP2/PTN/EPHA7/ADGRL3/UNC13C/SHANK3/CDH8/PTPRD/ZDHHC2/BDNF/PPFIBP2/SPARCL1/COL4A5/PALM/MYOT/PDZRN3/PAK3/GPM6A/EFNB2/MEF2C/SPARC/DMPK/PPP1R9A/FLNA/RELN/LRRN1/C1QL3/PCDH17/CDH2/ARHGEF15/NTRK2/LGI2/AMIGO2/CX3CR1/MYH10/C3 GOBP_SKELETAL_SYSTEM_DEVELOPMENT -1.542837293 4.95E-05 0.001958831 FBN2/ROR2/RASSF2/HOXB2/MUSTN1/EXT1/THBS3/FGF18/COMP/RARG/SLC2A10/NAB1/HYAL1/SOX9/THRA/SPNS2/ADAMTS7/MDFI/PKD1/TRIM45/TAL1/ALPL/HOXB4/PDGFC/BBS2/WWOX/PRELP/WNT5A/RAB33B/LEP/HOXA2/OSR2/RANBP3L/WNT11/FGFR2/RSPO2/MAF/BMP4/TLL1/STC1/HOXD8/HOXB3/JAG2/COL1A2/GDF10/MMP16/PTGER4/HYAL2/FST/CYP26B1/RBP4/ZMPSTE24/COL9A2/FOXC1/TNFRSF11B/SCX/OSR1/RARB/MEF2C/PKDCC/PLS3/ITGB8/EDN1/ACAN/HAPLN1/ACVRL1/LUM/RAB23/FRZB/TMEM119/HAND2/CLEC3A/GPLD1/BMP6/LRRC17/COL10A1/SFRP1/FREM1/TGFB2/IGF1/NPR3/MYOC/TEK/CYTL1/SFRP2/SFRP4/IGF2 GOBP_CANONICAL_WNT_SIGNALING_PATHWAY -1.506055648 0.000460376 0.009264133 SFRP5/JRK/GPC5/ZBED3/WNK2/MITF/SEMA5A/TBL1XR1/DAAM2/TNN/CCNY/MCC/FZD1/HESX1/CCDC88C/RAPGEF1/ISL1/ROR2/FERMT1/BAMBI/EXT1/RARG/SOX9/NOTCH1/DAPK3/LRRK2/RSPO1/PPM1B/TBL1X/WNT5A/JUP/TMEM170B/LGR6/WNT11/FZD2/FGFR2/RSPO2/LGR5/FZD6/DKK2/FZD8/FZD4/DKK3/SOX10/SOX17/ILK/CAV1/PRICKLE1/ADGRA2/FGF10/KLF4/FZD7/HHEX/DACT1/RSPO3/FRZB/MIR145/SOST/TMEM88/SOX7/SFRP1/CDH2/NKD1/GPRC5B/NR4A2/IGFBP6/ANKRD6/CTHRC1/NRARP/GPC3/SFRP2/SFRP4 GOBP_PATTERN_SPECIFICATION_PROCESS -1.519908958 0.00031396 0.006934192 NDRG4/TGFBR1/C1QA/NR2F2/IFT172/TCF15/ERBB4/TTC8/BMPR1B/DYNC2LI1/VANGL2/SIX1/EPB41L5/ISL1/TBX20/ROR2/HOXB2/IRX1/EXT1/GALNT11/RARG/MDFI/ALDH1A2/NOTCH1/HOXB4/WNT5A/AR/HOXA2/HES4/HEY1/BHLHE41/WNT11/FGFR2/BMP4/CTNNBIP1/STC1/TCAP/TBX5/HOXD8/HOXB3/SEMA3A/FST/CYP26B1/SOX17/CXXC4/FOXC1/OSR1/MEF2C/HEY2/EDN1/FGF10/SOX18/ACVRL1/DLL4/SEMA3C/HHEX/PKD2/RELN/HAND2/SFRP1/NKD1/EGR2/MEOX1/NRARP/GPC3/SFRP2/C3 GOBP_PROTEIN_KINASE_B_SIGNALING -1.462099581 0.00267599 0.031276893 PIK3CG/GPER1/FGF7/F10/PTK2/LEP/CCL5/FGFR2/RASD2/PIK3C2B/ESR1/P2RY12/HYAL2/ERBB3/PDGFB/RRAS/F3/CCL3/TMEM100/FGF10/KLF4/HBEGF/ANGPT1/MIR145/CCL19/GAS6/IGF1/NTRK2/BTC/MYOC/TEK/CX3CR1/KDR/RAMP3/IGF2/H19/CCL21 GOBP_AXON_DEVELOPMENT -1.565927879 1.73E-05 0.000887088 ERBB2/GDF7/LAMB2/TNN/PLXNB1/HDAC6/MAP1B/MAP1A/EZR/PTPRM/FLRT2/OPHN1/EMB/BMPR1B/EPHA5/MYPN/BCL2/CDKL5/ISL1/SKIL/MAPK1/VCL/SLITRK3/FLRT3/MCF2/EXT1/SCARF1/NREP/PLXNB3/FEZ1/RND2/SEMA3B/GFRA3/EPHB3/BOC/CNTN4/SEMA3E/B3GNT2/UNC5C/NOTCH1/SLITRK1/NDN/LAMA5/L1CAM/JAK2/NPTN/SPTAN1/SPTBN1/WNT5A/PTK2/NLGN3/NEO1/PLXNA1/HOXA2/LGR6/PTN/LGI1/FGFR2/ADARB1/SEMA6A/EPHA7/SHANK3/NTN4/SEMA3A/ADCY1/ANOS1/OLFM1/BDNF/MAP2/MYOT/PAK3/EFNB2/SLIT2/NCAM1/CRABP2/EPHB4/SLIT3/DCLK1/KLF4/SEMA3C/EPHA3/S100B/FLNA/CHODL/RELN/THY1/TSPAN2/ROBO4/PDLIM7/SEMA3D/NEXN/CDH2/EGR2/PLP1/NR4A2/NTRK2/GFRA1/SEMA3G/APOD GOCC_SIDE_OF_MEMBRANE -1.595998716 3.98E-06 0.00026323 ITGA1/SNAP25/CD3D/CAPN2/GNGT2/CD83/EPM2AIP1/CACNB4/ADA/SNX18/EZR/ADGRA3/BTN3A2/IGHV3-48/PTPN3/HLA-B/IL2RB/EPHA5/IGHV3-21/IGKC/GNAI1/IGHV3-30/CYTH3/ATP2B1/CD40LG/TRDC/S1PR1/CD24/EEF1A2/CD8A/CUBN/GM2A/TF/IGHV1-18/RAET1E/IGHV3-49/INSR/SLC4A3/TRGV10/ESYT1/MYZAP/IGHG3/GNG7/GFRA3/TLR4/CDIP1/IGHV3-11/GNRH1/IGLC6/STAB2/FRK/RGS1/CD3E/HLA-DQB2/ENOX2/AZGP1/CD79B/LRRK2/F10/BTN3A3/PTK2/GNG11/JUP/IL12RB2/HFE/SCUBE1/CXCL10/IGHV3-33/FCGRT/SHANK3/KCNAB1/GNAZ/IL11RA/TRAF5/ACE/ENPEP/TRBC2/FOLR2/IGHG4/P2RY12/HYAL2/IGHV4-39/HLA-DQA1/IGHV4-59/HLA-DQB1/PALM/BCAM/CD74/IGHV3-23/F3/SLC2A4/CD248/NCAM1/GNB4/CD1C/IGHM/IGHV3-7/HLA-DRA/HLA-DPA1/CAV2/KCNJ3/ATP1B2/PKD2/HEG1/MCAM/THY1/IGHG1/HLA-DRB1/PGM5/AKAP5/CXCL9/HLA-DQA2/CA4/CNTFR/GRIA2/RPS28/CD69/CD34/IL31RA/IGHG2/GPIHBP1/ACKR3/ABCG2/IGHA1/SELP/IGHA2/GEM/GFRA1/CX3CR1/CDH5/ACKR4/CLEC14A/SCARA5 GOCC_CELL_PROJECTION_MEMBRANE -1.498656648 0.000862865 0.01393583 BBS9/EVC/SGCE/EZR/TTC8/ATP8B1/MYO1C/ATP2B1/KCNB1/EPB41L5/LAMP5/CDKL5/BMX/CUBN/C2CD5/FERMT1/EHD1/ARHGEF4/INSR/EPS8L2/BVES/PKD1/GABRA4/GPER1/LIMA1/BBS2/MXRA8/SPTBN1/CASK/CYBRD1/PSD3/RASGRP2/DLC1/CLASP2/SHANK3/MYO1D/AIF1L/P2RY12/PALM/ITGA8/SH2D3C/FSCN1/SLC26A2/DPP4/DMD/ATP1B2/MTTP/PKD2/THY1/AKAP5/FGD5/CA4/EHD3/CYS1/GRIA1/TPM1/ABCG2/FAM107A/PROM1/SLC26A4/ITLN1/PODXL GOCC_CELL_CORTEX -1.493408807 0.001169836 0.01757015 C2CD5/RAI14/NSMF/GRK4/GYPC/BFSP1/RND2/MYZAP/FRYL/CALB2/PCLO/ADD3/PARD3B/SNCA/MYADM/SPTAN1/SPTBN1/PTK2/PSEN2/CTTNBP2/DCDC2C/PARD6G/FGFR2/HFE/CALD1/UNC13C/DLC1/EPB41L2/EXOC6/FRY/CLASP2/RIMS3/MYO1D/FLNB/AQP7/MYL12B/SELE/CAV1/FSCN1/MYO5B/PPP1R9A/CRIP2/FLNA/PKD2/MYRIP/MPP7/DSTN/HMCN1/RHOBTB1/CDH2/CLIC5/ACTN2/MYH10 GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY -1.520161815 0.000456152 0.009238945 GNAI1/KCNB1/ROCK2/RAB40B/GPC6/GRIP1/C2CD5/PRKG2/CCDC88A/EHD1/KIF13A/PPP2R5A/PKP2/F11R/STX7/LIN7B/ZDHHC8/CD81/SLC9A3R2/PID1/GPER1/LAMA5/BBS2/ARL6IP5/MYADM/SPTBN1/JUP/AR/CSRP3/NHLRC1/LGI1/ATP1B1/TSPAN33/EPB41L2/CLASP2/ZDHHC2/PALM/CAV1/PKDCC/PRKCH/EPHA3/RAMP1/FLNA/ADAM22/GRIN2A/MRAP2/AKAP5/TMEM88/GAS6/EHD3/CDH2/ACTN2/ADIPOQ/RAMP3/RAMP2 GOBP_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS -1.552403396 7.67E-05 0.002677829 RHOBTB2/DIXDC1/RICTOR/ARHGEF10/DMTN/CORO2B/INPP5K/SVIL/CTTN/FES/SEMA5A/LIMCH1/SRI/TGFBR1/GPM6B/CGNL1/CCL11/ARPIN/CD47/EPHA5/MYO1C/SORBS3/MYLK3/KCNJ2/ROCK2/TMSB4X/S1PR1/ARPC1A/GMFG/LMOD3/PICK1/CCDC88A/PKP2/F11R/RND2/SEMA3E/ADD3/LIMA1/PROX1/SYNPO2L/KANK4/DAPK3/SYNPO2/MYADM/SPTAN1/ESAM/SPTBN1/JUP/PAM/WNT11/CDC42EP2/KANK3/TNNC1/RYR2/ARHGEF10L/LMOD1/DLC1/MYBPC3/STC1/CLASP2/SHANK3/FHOD3/LMOD2/CFL2/PTGER4/DSG2/PFN2/CTNNA3/BST1/ATP1A2/CAV1/FSCN1/ASAP3/PAK3/SLIT2/CNN2/EDN1/PPP1R9A/EPHA3/FLNA/ELN/DSP/TMOD2/DSTN/RHOBTB1/FRMD7/PLN/SFRP1/ARHGEF15/TPM1/MYOC/FAM107A/ACTN2/TEK/RGCC/CCL21 GOBP_DEVELOPMENTAL_MATURATION -1.476680364 0.00250476 0.030101586 SOX8/BCL2/S1PR1/GATA2/PICK1/FERMT1/THBS3/SCARF1/BFSP1/AGRN/ALDH1A2/TUSC2/TAL1/CEBPA/LRRK2/WNT5A/LEP/LGI4/UNC13C/NTN4/KCNIP2/ZDHHC2/PALM/SOX10/EDNRB/PPARG/SOX18/ACVRL1/RELN/LHX6/CCL19/PGR/ARHGEF15/TGFB2/IGF1/NR4A2/MYOC/KLF2/CX3CR1/CDH5/CCL21/C3 GOBP_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY -1.460934569 0.005072835 0.048527522 CCDC88C/RAPGEF1/VGLL4/ISL1/ROR2/FERMT1/ALPK2/SOX9/MDFI/NOTCH1/WWOX/WNT5A/TMEM170B/WNT11/CTNNBIP1/FZD6/DKK2/FZD4/DKK3/NXN/SOX10/SOX17/CAV1/CXXC4/PRICKLE1/DACT1/FRZB/SOST/TMEM88/SFRP1/CDH2/NKD1/IGFBP6/ANKRD6/CTHRC1/GPC3/SFRP2/SFRP4 GOBP_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE -1.505569405 0.000875217 0.01401106 KCNB1/ROCK2/RAB40B/GRIP1/C2CD5/PRKG2/CCDC88A/EHD1/KIF13A/PPP2R5A/PKP2/F11R/STX7/ZDHHC8/CD81/SLC9A3R2/PID1/GPER1/LAMA5/BBS2/ARL6IP5/MYADM/SPTBN1/JUP/AR/CSRP3/NHLRC1/ATP1B1/TSPAN33/CLASP2/ZDHHC2/PALM/PKDCC/PRKCH/EPHA3/RAMP1/FLNA/MRAP2/AKAP5/TMEM88/GAS6/EHD3/CDH2/ACTN2/ADIPOQ/RAMP3/RAMP2 GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY -1.460509814 0.004638264 0.045204903 FBN2/SKIL/FERMT1/ITGB5/MIR17HG/BAMBI/PMEPA1/NREP/CDKN2B/LTBP4/SLC2A10/F11R/FMOD/VASN/CIDEA/PTK2/HTRA1/COL1A2/IL17RD/TWSG1/GDF10/CD109/DKK3/LTBP2/TGFB1I1/CAV1/HTRA3/ITGB8/CAV2/ACVRL1/CDKN1C/RASL11B/JUN/TGFB2/LEFTY2/LTBP1/ASPN/CDH5/FOS GOBP_REGULATION_OF_TRANS_SYNAPTIC_SIGNALING -1.542923951 0.000194723 0.004962257 CLSTN1/RNF19A/SNAP25/MAP1B/MAP1A/SYNGR1/MME/IGSF11/OPHN1/CLSTN2/GNAI1/KCNB1/ROR2/PICK1/MAPK1/NSMF/TMEM25/USP46/CNTN4/CALB2/CBLN1/NLGN4X/MCTP1/GRIK3/GPER1/JAK2/NPTN/LRRK2/NLGN3/KCNMB4/PTN/LGI1/NCS1/UNC13C/SHANK3/RIMS3/ADRA2A/PTPRD/ADRB2/ADCY1/PLK2/ZDHHC2/BDNF/PLCB1/NPTXR/ATP1A2/CALM1/MEF2C/RIMS4/NPY5R/EDN1/DMPK/PRRT2/BCHE/PPP1R9A/RELN/GRIN2A/PRKAR2B/AKAP5/PLCB4/PCDH17/CDH2/EGR2/GRIA1/NTRK2/FAM107A/ADIPOQ/CX3CR1 GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT -1.518044554 0.000558287 0.010519472 FUT1/WNT5A/LEP/JUP/PTN/HSPG2/SEMA6A/CXCL10/DDAH1/CYBB/PLK2/SMOC2/RRAS/CTSH/S100A1/F3/FOXC1/ADGRA2/SPARC/PPARG/ITGB8/NOS3/KLF4/NPR1/HHEX/MIR145/TSPAN12/TIE1/SFRP1/CD34/TGFB2/THBS4/FLT1/PPP1R16B/TEK/ANGPTL7/KLF2/CX3CR1/ANXA3/CDH5/KDR/SFRP2/RGCC/APLNR/RAMP2/ECSCR/SERPINF1/DCN/C3 GOBP_SENSORY_ORGAN_DEVELOPMENT -1.58537202 3.46E-05 0.00149268 TCF15/PTPRM/HESX1/ATP8B1/BMPR1B/MDM1/SIX1/SOX8/ATP2B1/BCL2/COL8A2/FBN2/ROR2/GATA2/SKIL/MAPK1/COL5A1/RHOJ/KCNQ4/MCOLN3/FSCN2/RARG/BFSP1/OBSL1/SOX9/RORB/AGTPBP1/ALDH1A2/NOTCH1/CEBPA/PROX1/CPAMD8/MYOM2/WNT5A/BNC2/HOXA2/VIM/OSR2/ALDH1A3/PTN/FZD2/UNC45B/FGFR2/MAF/BMP4/TCAP/LGR5/JAG2/FZD6/NES/LRIG3/TWSG1/CRYAB/FZD4/CYP26B1/RBP4/MAB21L1/FOXC1/OSR1/RARB/GPM6A/SPARC/HEY2/EDN1/FGF10/KLF4/ACVRL1/DLL4/FRZB/THY1/MYOM1/TSPAN12/HAND2/BMP6/NKD1/ARHGEF15/TGFB2/NTRK2/FLT1/CTHRC1/THRB/PROM1/ANGPTL7/MFAP5/CYTL1/SERPINF1/CHRDL1/CXCL14 GOBP_REGULATION_OF_ACTIN_FILAMENT_ORGANIZATION -1.516454541 0.001909234 0.025383857 RICTOR/ARHGEF10/DMTN/CORO2B/INPP5K/SVIL/CTTN/SEMA5A/LIMCH1/TGFBR1/CGNL1/CCL11/ARPIN/CD47/MYO1C/SORBS3/ROCK2/TMSB4X/S1PR1/ARPC1A/GMFG/LMOD3/PICK1/CCDC88A/F11R/ADD3/LIMA1/SYNPO2L/KANK4/SYNPO2/MYADM/SPTAN1/ESAM/SPTBN1/WNT11/CDC42EP2/KANK3/ARHGEF10L/LMOD1/DLC1/CLASP2/SHANK3/FHOD3/LMOD2/CFL2/PTGER4/PFN2/ASAP3/PAK3/SLIT2/PPP1R9A/FLNA/ELN/TMOD2/DSTN/FRMD7/SFRP1/ARHGEF15/TPM1/MYOC/ACTN2/RGCC/CCL21 GOBP_LIPID_CATABOLIC_PROCESS -1.525045069 0.000562556 0.010567903 BDH2/ECI1/PLA2G5/YWHAH/GBA2/HSD17B11/ECHDC2/PLCB2/ACAA2/SCARB1/NAPEPLD/CYP27A1/IVD/PHYH/PEX2/EHHADH/LGALS12/SRD5A1/PLA2G6/SIRT2/IAH1/NUDT7/ACAT2/ACOX3/GDPD1/ECHS1/PLCD3/AIG1/ACADL/GM2A/PLCD1/DDHD2/PNPLA4/PCK1/SCARF1/PECR/LPIN3/STS/CPT1A/PLA1A/THRA/PNPLA7/PIK3CG/LIPE/PLD1/PLCG2/CIDEA/CRABP1/LEP/PLBD1/NAAA/ABCD2/ACAT1/PCCB/ADRA2A/HADH/PNPLA2/ASAH1/CYP26B1/PLCB1/SORL1/FUCA1/CES1/MGLL/RARRES2/ACACB/GPLD1/PLCB4/APOB/PLIN1/ADIPOQ/LPL/FABP3/PLA2G2A/FABP4 GOBP_CELL_FATE_COMMITMENT -1.461589565 0.00528561 0.049496874 MITF/IRF4/GDF7/TGFBR1/NR2F2/ERBB4/SIX1/SOX8/BCL2/ISL1/TBX20/ROR2/GATA2/PRDM1/EXT1/LMO4/SOX9/NOTCH1/TAL1/PROX1/TOX/WNT5A/AR/HOXA2/GAS1/WNT11/FGFR2/BMP4/TBX5/JAG2/CYP26B1/SOX17/TGFB1I1/NOTCH4/MEF2C/PPARG/HEY2/FGF10/KLF4/SOX18/FZD7/DLL4/ZNF521/EBF2/SFRP1/SFRP2 GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS -1.547582451 0.000185722 0.004857538 EZR/IGHV3-48/OPHN1/CD207/IGLV1-40/IGKC/IGHV3-30/SNAP91/IGKV1-12/CUBN/TF/IGLV3-19/PICK1/GRK4/SCARF1/HBA1/INSR/USP46/HBA2/IGKV2-30/CD81/IGHV3-11/IGLC6/STAB2/SNCA/PLCG2/RSPO1/SIGLEC1/NLGN3/ARRB1/HSPG2/HFE/IGKV1-5/IGHV3-33/SH3GL3/IGLV2-14/ADRB2/SCGB3A2/IGHV4-39/IGHV4-59/SORL1/IGLV2-23/CD9/SELE/CAV1/IGHV3-23/IGKV3-20/SPARC/CALCRL/IGHV3-7/CAV2/RAMP1/ANGPT1/PDLIM7/CCL19/MASP1/HBB/GRIA1/APOB/ACKR3/IGHA1/IGHA2/GSG1L/ADIPOQ/RAMP3/JCHAIN/SFRP4/RAMP2/CCL21/C3 GOBP_BEHAVIOR -1.611885551 7.78E-06 0.000447759 ARF4/OPRK1/SRD5A1/NDRG4/NAGLU/ADCY3/SNAP25/CAPN2/ATXN1/ADA/ADRB1/MAP1A/IDO1/SGK1/CCL11/TCF15/CLDN5/MME/DACH1/RNF180/BCL2/GLRB/GM2A/DDHD2/MAPK1/VPS13A/EXT1/INSR/MCOLN3/CPT1A/USP46/DYNLRB1/THRA/ZDHHC8/NLGN4X/GPR176/TAL1/SLITRK1/PREX2/BBS2/NPTN/LRRK2/ARL6IP5/HPGDS/NLGN3/LEP/ALDH1A3/PTN/LGI4/RASD2/ADARB1/ADCY5/CIART/SHANK3/ADCY1/FZD4/PLK2/BDNF/PLCB1/FGF12/ATP1A2/VWA1/SCN9A/ZMPSTE24/GLS/SLC2A4/DPP4/MEF2C/CCL3/NPY5R/BCHE/ATP8A1/GATM/S100B/ATP1B2/ADAM22/RELN/GRIN2A/MRAP2/NR4A3/PRKAR2B/AVPR1A/TMOD2/NR1D2/NEGR1/HAND2/CNTFR/PCDH17/JUN/EGR2/GRIA1/THBS4/PER3/NR4A2/NTRK2/THRB/NPY1R/CX3CR1/PTGDS/FOS/SERPINF1 GOBP_MESENCHYME_DEVELOPMENT -1.538521418 0.000571261 0.010650455 TCF15/ERBB4/FAM83D/ZFPM2/SIX1/ELL3/SOX8/BCL2/EPB41L5/ISL1/TBX20/MAPK1/BAMBI/EXT1/SEMA3B/SOX9/FBXL17/SEMA3E/VASN/ALDH1A2/NOTCH1/LAMA5/WNT5A/BNC2/S100A4/HEY1/RANBP3L/WNT11/FGFR2/SEMA6A/BMP4/CLASP2/TBX5/SEMA3A/IL17RD/ERBB3/OLFM1/SOX10/TGFB1I1/EDNRB/NOTCH4/FOXC1/SCX/OSR1/MEF2C/TMEM100/HEY2/RBM24/EDN1/ACTG2/NOS3/FGF10/ACVRL1/SEMA3C/EPHA3/FLNA/PKD2/FRZB/HAND2/SEMA3D/SFRP1/CDH2/TGFB2/MEOX1/ACTA2/SEMA3G/SFRP2/RGCC/ACTC1 GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY -1.56049266 0.00021383 0.005297184 KCNK7/SCN3B/ANO2/ANO10/KCNK2/SCN5A/ANXA6/TMC8/SCNN1D/TRPV1/TMC6/TMEM38A/TRPM4/TMC7/KCNC4/KCNH2/GRID1/KCNS3/ANO1/LRRC8D/SCN1B/CLIC6/HVCN1/KCNJ12/KCND2/KCNMB2/MCU/SCNN1B/CLIC3/NALCN/SCN2B/KCNB2/TRPM6/SNAP25/CACNB4/CHRNE/SLC26A7/ANO6/KCNA5/GJD3/VDAC3/KCNJ2/BCL2/KCNB1/GLRB/KCNMB1/FAM155B/KCNQ4/MCOLN3/KCNK5/TMEM109/GJC1/PKD1/GABRA4/GRIK3/KCNA4/TMEM37/CACNA2D3/GABRB1/KCNA3/KCNMB4/CLCN4/GJA4/TRPC1/TMEM175/NCS1/RYR2/FXYD1/KCNJ8/SLC1A4/SCN3A/KCNAB1/KCNK6/KCNK17/ABCC9/CYBB/KCNIP2/AQP7/TRPC6/RYR3/SCN9A/GPM6A/TMEM150C/ANO5/KCNN3/KCNMA1/KCNJ3/PKD2/GRIN2A/CLIC2/GRIA2/GRIA1/SLC24A4/SCN4B/CLIC5/SCN7A GOMF_SULFUR_COMPOUND_BINDING -1.525918745 0.001041031 0.015943677 GREM2/ANG/CRISPLD2/EFEMP2/IMPG2/CCL8/GSTM2/ACOT11/ACADL/POSTN/COL5A1/THBS3/COMP/AGRN/PCOLCE2/ADAMTSL5/ADAMTS5/CXCL11/CTSG/FGF7/VEGFB/PRELP/RSPO1/LGR6/PTN/FGFR2/RYR2/RSPO2/NELL2/CXCL10/BMP4/COL25A1/GSTP1/ALDH6A1/ANOS1/SMOC2/FST/LTBP2/N6AMT1/COLQ/SELL/FSTL1/SLIT2/FGF10/SLIT3/HBEGF/RSPO3/ECM2/SOST/TNXB/ACACB/SFRP1/CD34/THBS4/APOB/SELP/CLEC3B/LPL GOCC_RECEPTOR_COMPLEX -1.611342657 2.44E-05 0.001139614 ERBB2/TRAV39/TGFBR1/ITGA1/PLXNB1/CD3D/ROR1/TRBJ2-5/CHRNE/TRBV20-1/TRAV19/LOXL4/ERBB4/ITGA9/TRAJ3/IMPG2/IL2RB/BMPR1B/EPHA5/TRBJ2-6/TRDC/ROR2/CD8A/CUBN/TF/ITGB5/GPR20/INSR/ACVR1C/PLXNB3/TRBJ2-2/AHR/TRGV10/TLR7/GFRA3/EPHB3/ADCYAP1R1/TLR4/NOTCH1/GABRA4/GRIK3/OLFM2/CD3E/CD79B/NR3C2/GABRB1/TRIL/FLT4/PLXNA1/TRPC1/IL12RB2/FGFR2/HFE/EPHA7/PLXDC1/SHANK3/PTPRQ/IL11RA/TRAF5/ADRA2A/ADRB2/TRBC2/ERBB3/CD74/ITGA8/TRAC/ITGA7/PPARG/ITGB8/EPHB4/CALCRL/ACVRL1/ITGBL1/NPR1/EPHA3/RAMP1/MTTP/GRIN2A/CNTFR/NT5DC3/GRIA2/TIE1/GRIA1/GPRC5B/PLP1/IL31RA/NTRK2/FLT1/TEK/ITGB4/GFRA1/KDR/ITGA6/RAMP3/ITLN1/PTPRB/RAMP2 GOBP_SKELETAL_SYSTEM_MORPHOGENESIS -1.489916166 0.004206933 0.042123526 SIX1/FBN2/ROR2/HOXB2/EXT1/THBS3/FGF18/COMP/RARG/NAB1/HYAL1/SOX9/THRA/MDFI/PKD1/ALPL/HOXB4/WWOX/RAB33B/HOXA2/OSR2/FGFR2/BMP4/STC1/HOXD8/HOXB3/MMP16/HYAL2/CYP26B1/ZMPSTE24/FOXC1/SCX/OSR1/RARB/MEF2C/RAB23/TMEM119/BMP6/SFRP1/FREM1/TEK/SFRP2/SFRP4 GOBP_SENSORY_SYSTEM_DEVELOPMENT -1.565999385 0.000227807 0.005511678 NAGLU/LAMB2/TGFBR1/C1QA/IFT172/TUG1/PTPRM/HESX1/BMPR1B/MDM1/SOX8/ATP2B1/BCL2/COL8A2/ISL1/FBN2/SKIL/COL5A1/RHOJ/FSCN2/RARG/BFSP1/OBSL1/SOX9/RORB/AGTPBP1/ALDH1A2/PROX1/CPAMD8/MYOM2/WNT5A/VIM/OSR2/ALDH1A3/PTN/UNC45B/MAF/BMP4/SEMA3A/NES/TWSG1/CRYAB/FZD4/P2RY12/RBP4/MAB21L1/FOXC1/RARB/GPM6A/FGF10/KLF4/ACVRL1/DLL4/THY1/MYOM1/TSPAN12/BMP6/NKD1/ARHGEF15/TGFB2/NTRK2/FLT1/THRB/PROM1/ANGPTL7/MFAP5/SERPINF1/C3/CHRDL1 GOBP_RESPONSE_TO_ALCOHOL -1.508573798 0.00277105 0.032026751 ADCY2/KCNMB1/AHR/CPT1A/USP46/FECH/GNRH1/NLRP3/CCND1/LEP/JUP/FGFR2/ADCY5/GSTP1/CLDN1/CA3/CYBB/ADCY1/PTGER4/RBP4/CALM1/SLC2A4/CCL3/CES1/SLIT2/SPARC/PPARG/SLIT3/KLF4/GRIN2A/AVPR1A/PTGFR/CCL19/GPLD1/OXCT1/SFRP1/FOSB/ADIPOQ/KLF2/ACTC1/FOS/CCL21 GOBP_CONNECTIVE_TISSUE_DEVELOPMENT -1.522554926 0.001196212 0.017879919 BMPR1B/CHADL/SOX8/ROR2/MUSTN1/SLC39A13/GPR4/COL5A1/EXT1/THBS3/PPARGC1A/FGF18/COMP/RARG/HYAL1/SOX9/THRA/ADAMTS7/PKD1/NOTCH1/BBS2/WNT5A/LEP/OSR2/WNT11/RSPO2/MAF/BMP4/STC1/PDGFD/HOXB3/HYAL2/PDGFB/SORL1/ZMPSTE24/SCX/OSR1/RARB/MEF2C/PKDCC/ITGB8/EDN1/ACVRL1/LUM/FRZB/CRIP1/EBF2/HAND2/GPLD1/BMP6/OXCT1/CD34/ACTA2/CYTL1/SFRP2 GOBP_ACTIN_FILAMENT_ORGANIZATION -1.635092397 3.40E-06 0.000237595 ARHGAP28/FAM171A1/RHOBTB2/POF1B/RICTOR/ARHGEF10/COBL/DMTN/MCU/CORO2B/INPP5K/SVIL/CTTN/ZBED3/SEMA5A/LIMCH1/TGFBR1/SHROOM1/XIRP1/CGNL1/ELMO1/MICAL3/CCL11/EZR/ARPIN/ANG/CD47/SPATC1L/MYO1C/ARHGAP12/SORBS3/BCL2/ROCK2/TMSB4X/S1PR1/ARPC1A/GMFG/TF/LMOD3/TPM2/PICK1/CCDC88A/ITGB5/FSCN2/F11R/RND2/ARHGAP25/ADD3/LIMA1/DIAPH3/PROX1/SYNPO2L/KANK4/SYNPO2/JAK2/MYADM/SPTAN1/ESAM/SPTBN1/WNT11/CDC42EP2/KANK3/ARRB1/NRAP/ARHGEF10L/LMOD1/GAS7/CALD1/DLC1/MARCKSL1/CLASP2/TCAP/SHANK3/FAT1/FHOD3/CORO6/MYO1D/LMOD2/CFL2/AIF1L/PTGER4/PFN2/CTNNA3/FSCN1/ASAP3/PAK3/MYO5B/SLIT2/NEBL/PLS3/PPP1R9A/FLNA/ELN/TTN/MYO5C/TMOD2/DSTN/SORBS2/RHOBTB1/FRMD7/SFRP1/ARHGEF15/TPM1/MYOC/FAM107A/ACTN2/RGCC/ACTC1/CCL21 GOBP_NEGATIVE_REGULATION_OF_ION_TRANSPORT -1.567967108 0.000443243 0.00909599 INPP5K/ENY2/WNK2/INSIG1/SRI/MAOB/GPM6B/ADA/ERP29/CRY1/MIR103A1/ISCU/AGTR2/BCL2/KCNB1/GSTM2/RAB11FIP5/PRKG2/FERMT1/SLC43A1/MDFIC/ERLEC1/ACVR1C/MIR766/CALM2/BARD1/WWP2/PID1/SNCA/LRRK2/ARL6IP5/INHBB/SREBF2/LEP/ADRA2B/STC1/KCNAB1/STK39/ADRA2A/P2RY12/FGF12/SLN/ATP1A2/RSAD2/CD74/CAV1/CALM1/OSR1/PKDCC/NPY5R/REM1/RAB23/ANGPT1/PKD2/CLIC2/PLN/SFRP1/ACTN2/ADIPOQ/GEM/CASQ2/SFRP4/APOD GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS -1.517909102 0.00265498 0.031089761 ELOVL2/HOGA1/IDO1/RGN/PRKAG2/ACSM5/PER2/ELOVL4/GSTM2/ACADL/PECR/THNSL2/MIR766/DHRS9/ALDH1A2/HACD4/PROX1/HPGDS/OSBPL1A/SCD/FADS2/ALDH1A3/OSBPL3/TECRL/ABCD2/GSTP1/GPX4/CD74/CES1/MGLL/EDN1/ELOVL7/GATM/AVPR1A/HACD1/CH25H/ACACB/PLP1/ADIPOQ/LPL/PTGDS GOCC_SITE_OF_POLARIZED_GROWTH -1.502901931 0.00255826 0.030415414 PALLD/MYO9A/TIAM2/RTN4R/AMFR/ARHGAP4/ARPC5/PTPRS/APBB1/KIF20B/KIF5B/COBL/TIAM1/CTTN/GDPD5/SIRT2/SNAP25/DCTN2/MAP1B/SLC2A13/STMN2/ANG/IGHMBP2/LAMP5/CDKL5/COPG2/FLRT3/TIMP2/NGEF/FEZ1/FRYL/BOC/UNC5C/L1CAM/APBB2/SNCA/LRRK2/PSEN2/EXOC6/FRY/NDRG2/OLFM1/FSCN1/MAP2/CALM1/GPM6A/PPP1R9A/FLNA/THY1/TMOD2/FRMD7 GOBP_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING -1.499769212 0.004584986 0.044896761 PIK3CG/FGF7/F10/PTK2/LEP/FGFR2/RASD2/ESR1/P2RY12/ERBB3/PDGFB/F3/CCL3/FGF10/HBEGF/ANGPT1/CCL19/GAS6/BTC/MYOC/TEK/CX3CR1/RAMP3/IGF2/H19/CCL21 GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION -1.639290271 8.26E-06 0.000466797 LAMB2/TGFBR1/ADAMTS17/ITGA1/ICAM3/JAM2/CAPN2/GPM6B/LOXL1/LOXL4/ADAMTS2/TCF15/MPZL3/FLRT2/CRTAP/TNXA/CRISPLD2/ITGA9/CD47/EFEMP2/CHADL/LAMA4/COL4A6/COL8A2/FBN2/COL4A3/SPOCK2/FERMT1/SCUBE3/HAS1/POSTN/ADAMTS6/ITGB5/COL5A1/EXT1/TIMP2/POMT1/SERAC1/COMP/LAMC1/SLC2A10/AGRN/F11R/CST3/SOX9/FMOD/ADAMTS7/ADAMTSL5/ADAMTS5/FBLN5/NOTCH1/NPNT/ADAMTSL3/LAMA5/PXDN/COL16A1/CTSG/HSPG2/SCUBE1/TLL1/HTRA1/CLASP2/NTN4/COL1A2/MMP16/SMOC2/PDGFB/COL4A5/VWA1/ITGA8/COL9A2/CAV1/COLQ/FSCN1/SPINT2/COL28A1/FOXC1/TNFRSF11B/SCX/DPP4/SPARC/ITGA7/ITGB8/ACAN/MFAP4/KAZALD1/HAPLN1/ICAM2/MYH11/CAV2/LUM/ELN/ECM2/FBLN2/TNXB/MMP28/GAS6/COL12A1/TIE1/COL10A1/CTSK/VIT/COL15A1/TGFB2/FBLN1/ANGPTL7/OLFML2A/MFAP5/DPT/ITGB4/KDR/SFRP2/RGCC/ITGA6/RAMP2/PECAM1/DCN/VWF GOBP_OSSIFICATION -1.643529046 7.29E-06 0.000431909 SOX8/ATP2B1/BCL2/S1PR1/FBN2/ROR2/RASSF2/KL/MAPK1/BAMBI/EXT1/THBS3/FGF18/COMP/ISG15/ZBTB40/NAB1/SOX9/THRA/RORB/NOTCH1/NPNT/ALPL/CEBPA/ID3/WWOX/WNT5A/PTK2/LEP/HOXA2/OSR2/TWIST2/FSTL3/PTN/RANBP3L/WNT11/FGFR2/RSPO2/FHL2/JUND/CLEC11A/BMP4/CTNNBIP1/STC1/TOB1/COL1A2/ADRB2/TWSG1/GDF10/MMP16/PTGER4/IGSF10/ZMPSTE24/FOXC1/SCX/OSR1/SLC26A2/BCAP29/MEF2C/SORT1/CCL3/PKDCC/SPARC/PPARG/KAZALD1/SLC8A1/SOST/MN1/PDLIM7/TMEM119/HAND2/CLEC3A/GPLD1/BMP6/SFRP1/EGR2/TGFB2/IGF1/OMD/CRIM1/CTHRC1/MYOC/TEK/GPC3/CLEC3B/ASPN/TPH1/SFRP2/IGF2/CHRDL1 GOCC_SYNAPTIC_MEMBRANE -1.610206972 5.92E-05 0.002205054 CLTB/TRPV1/STXBP1/AKAP9/SRPX2/FAIM2/APBA1/PTPRS/GABBR1/SLITRK2/SSPN/GRID1/MX1/MX2/STX2/ZDHHC17/LRRC4/KCND2/SNPH/TIAM1/ABHD17B/DNM1/CLSTN1/SNAP25/CHRNE/ERBB4/CNKSR2/CLSTN2/RGS9/SNAP91/ATP2B1/KCNB1/IGSF9B/GRIP1/GLRB/PICK1/SLITRK3/FLRT3/KCTD12/SNTA1/LIN7B/CALB2/CBLN1/NLGN4X/GABRA4/SLITRK1/GRIK3/GPER1/NPTN/GABRB1/KCNA3/NLGN3/CNTN1/LRRC4B/PDE2A/CASK/ARRB1/EPHA7/UNC13C/SHANK3/RIMS3/CDH8/PTPRD/ADCY1/CRYAB/PALM/ITGA8/SYNE1/GPM6A/EFNB2/RIMS4/DMD/PRRT2/KCNMA1/KCNJ3/ADAM22/GRIN2A/SHC4/SLC8A1/GRIA2/PCDH17/CDH2/GRIA1/IL31RA/RGS7BP/ACTN2/GSG1L GOCC_VACUOLAR_LUMEN -1.518577403 0.004014584 0.041057047 MANBA/CYB5R3/GPC5/DSN1/CD1E/ACTR10/NAGLU/PLD3/NHLRC3/SDC3/GPC6/CUBN/GM2A/MAPK1/IDUA/AGRN/HYAL1/FMOD/FRK/CTSG/MNDA/PRELP/IDS/HSPG2/NAAA/VAT1/AGA/EPDR1/CTSF/ASAH1/CD74/FUCA1/PYGB/ACAN/LUM/CTSK/APOB/OMD/OGN/GPC3/DCN/C3 GOBP_REGULATION_OF_EPITHELIAL_CELL_MIGRATION -1.588712596 0.000463077 0.009288428 NR2F2/MCC/HDAC6/SASH1/PRCP/MIR101-1/PTPRM/MIR23A/VASH1/AGTR2/ROCK2/EPB41L5/TMSB4X/GATA2/RHOJ/STARD13/FGF18/HYAL1/SOX9/EPB41L4B/PIK3CG/NOTCH1/PROX1/ATOH8/FGF7/PLCG2/FUT1/WNT5A/PTK2/FLT4/JUP/HDAC5/PTN/CARD10/BMP4/STC1/CLASP2/SEMA3A/MMRN2/MIR410/PLK2/SMOC2/PFN2/PDGFB/RRAS/CTSH/MEF2C/SLIT2/ADGRA2/SPARC/PPARG/EDN1/NOS3/FGF10/KLF4/ACVRL1/DLL4/HBEGF/ANGPT1/GPLD1/TGFB2/TEK/ANXA3/KDR/RGCC/SERPINF1/DCN GOCC_NEURON_SPINE -1.521920839 0.003942251 0.040584303 MX1/MX2/LRRC4/KCND2/ARHGAP33/TIAM1/ABHD17B/CTTN/ARF4/DNM1/SRI/CLSTN1/MAP1B/EEF2K/OPHN1/KCNJ2/ATP2B1/CNN3/GPER1/CD3E/KCNA4/PTK2/CTTNBP2/ARRB1/SHANK3/CRYAB/PALM/ATP1A2/ITGA8/GPM6A/PRRT2/PPP1R9A/GRIN2A/SLC8A1/PRKAR2B/AKAP5/GRIA2/GRIA1/NTRK2/ACTN2/PALMD GOBP_METAL_ION_TRANSPORT -1.67680663 2.78E-06 0.000198621 CCL8/RGS9/KCNJ2/ATP2B1/BCL2/GSTM2/SLC25A23/SLC39A13/MICU3/FAM155B/MCOLN3/TUSC3/KCNK5/CNNM2/CRACR2B/CALM2/PKD1/PIK3CG/GPER1/CXCL11/SLC39A10/TMEM37/SNCA/PLCG2/CACNA2D3/PSEN2/SLC40A1/GJA4/CCL5/TRPC1/NCS1/RYR2/FXYD1/ATP1B1/CXCL10/MYLK/SMDT1/STC1/CASQ1/HRC/AHNAK/ADRA2A/KCNIP2/CYSLTR1/P2RY12/IL16/JPH2/PDGFB/TRPC6/SLN/RYR3/ATP1A2/ZMPSTE24/CAV1/CALM1/GPM6A/CCL3/DMD/CALCRL/TSPAN13/CAMK2G/WFS1/REM1/RAMP1/ATP1B2/PKD2/GRIN2A/SLC8A1/THY1/CLIC2/CXCL9/CCL19/GAS6/PLN/NPPA/EHD3/PLP1/SLC24A4/GEM/CASQ2/RAMP3/APLNR/RAMP2/CCL21 GOBP_NEGATIVE_REGULATION_OF_LOCOMOTION -1.63832615 2.36E-05 0.001124089 MITF/SEMA5A/LIMCH1/CHRD/NDRG4/TNN/NR2F2/MCC/SCAI/ADA/RGN/ARPIN/CLDN5/ERBB4/MIR101-1/DACH1/PTPRM/VASH1/AGTR2/BCL2/HAS1/VCL/PPARGC1A/ACVR1C/PLXNB3/STARD13/MIR218-1/TCAF1/SEMA3B/SEMA3E/DUSP3/MCTP1/NOTCH1/GNRH1/WNT5A/JUP/HDAC5/PTN/CARD10/WNT11/ADARB1/SEMA6A/DLC1/STC1/GSTP1/CLASP2/TBX5/SEMA3A/MMRN2/MIR410/PTGER4/HYAL2/PFN2/PLCB1/RRAS/CD74/SPINT2/DPP4/MEF2C/SLIT2/PPARG/DUSP1/KLF4/ACVRL1/DLL4/PODN/SEMA3C/ATP1B2/MIR145/THY1/MMP28/SEMA3D/TIE1/SFRP1/FBLN1/TPM1/MIR140/ADIPOQ/CX3CR1/SEMA3G/SFRP2/RGCC/SERPINF1/CCL21/DCN/APOD GOBP_ANATOMICAL_STRUCTURE_MATURATION -1.554462449 0.001782667 0.024084685 SOX8/BCL2/S1PR1/GATA2/PICK1/FERMT1/THBS3/SCARF1/BFSP1/AGRN/ALDH1A2/TUSC2/TAL1/CEBPA/LRRK2/WNT5A/LEP/LGI4/NTN4/KCNIP2/SOX10/EDNRB/PPARG/SOX18/ACVRL1/LHX6/CCL19/PGR/TGFB2/IGF1/NR4A2/MYOC/KLF2/CX3CR1/CDH5/CCL21/C3 GOBP_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY -1.523465406 0.003457243 0.03751682 DAPK3/LRRK2/RSPO1/PPM1B/TBL1X/JUP/LGR6/FGFR2/RSPO2/LGR5/DKK2/ILK/CAV1/ADGRA2/FGF10/HHEX/DACT1/RSPO3/MIR145/SFRP1/GPRC5B/NRARP/GPC3/SFRP2/SFRP4 GOBP_UROGENITAL_SYSTEM_DEVELOPMENT -1.634391503 3.42E-05 0.00149268 VANGL2/AGTR2/SIX1/SOX8/KLF15/BCL2/CD24/GATA2/IRX1/COL4A3/TREX1/GPR4/ADAMTS6/EXT1/ZBTB14/RARG/SOX9/EPHB3/PKD1/ALDH1A2/NOTCH1/NPNT/PROX1/LAMA5/ID3/LRRK2/WNT5A/AR/OSR2/FSTL3/KLHL3/WNT11/FGFR2/EPHA7/KCNJ8/BMP4/CTNNBIP1/LGR5/PDGFD/ESR1/ACE/ENPEP/HYAL2/CYP26B1/RBP4/PDGFB/SOX17/ITGA8/ZMPSTE24/CTSH/FOXC1/OSR1/RARB/MEF2C/SLIT2/FGF10/WFS1/AGTR1/ANGPT1/PKD2/CRIP1/BMP6/SFRP1/CD34/TGFB2/TEK/PROM1/GPC3/ADIPOQ/ACTA2/PODXL/PECAM1/SERPINF1/DCN GOBP_REGULATION_OF_CELL_JUNCTION_ASSEMBLY -1.553905019 0.002357317 0.029301195 CLDN5/EEF2K/FLRT2/CLSTN2/PDLIM5/MYO1C/SIX1/ROCK2/EPB41L5/RAPGEF1/GPC6/LRRN3/VCL/SLITRK3/FLRT3/AGRN/F11R/EPHB3/CBLN1/DUSP3/SLITRK1/DAPK3/COL16A1/SNCA/WNT5A/PTK2/NLGN3/LRRC4B/EPHA7/DLC1/CLASP2/CLDN1/PTPRD/ACE/BDNF/CAV1/MEF2C/PRKCH/ACVRL1/PPP1R9A/EPHA3/THY1/LRRN1/SFRP1/NTRK2/MYOC/FAM107A/TEK/AMIGO2/KDR/APOD GOBP_HUMORAL_IMMUNE_RESPONSE -1.611973869 0.000188554 0.004884931 IGHV3-21/IGLV1-40/CCL13/IGKC/IGHV3-30/IGKV1-12/BCL2/TRDC/TF/IGHV1-18/IGLV3-19/IGHV3-49/CXCL2/IGHG3/SPNS2/IGKV2-30/CD81/IGHV3-11/NOTCH1/IGLC6/CXCL11/SLPI/CTSG/IGKV1-5/CXCL10/IGHV3-33/IGLV2-14/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/HLA-DQB1/BST1/IGHV3-23/IGKV3-20/MEF2C/MFAP4/IGHM/IGHV3-7/RARRES2/IGHG1/HLA-DRB1/CXCL9/MASP1/CD55/C6/IGHG2/IGHA1/IGHA2/RGCC/CFI/ITLN1/JCHAIN/PLA2G2A/C3/C7/CXCL14/CFD GOBP_REGULATION_OF_CELL_SUBSTRATE_ADHESION -1.572357242 0.000876536 0.01401106 EFEMP2/RSU1/BCL2/ROCK2/EPB41L5/LGALS1/SPOCK2/FERMT1/POSTN/VCL/SEMA3E/DUSP3/NOTCH1/NPNT/CD3E/DAPK3/COL16A1/JAK2/MYADM/FUT1/PTK2/JUP/OLFM4/CASK/PTN/DLC1/CLASP2/FZD4/PDGFB/BST1/RRAS/ILK/ACVRL1/FZD7/EPHA3/FLNA/ECM2/LIMS2/FBLN2/THY1/ACTN4/SFRP1/VIT/FBLN1/MYOC/FAM107A/TEK/KDR/ITGA6/CCL21/APOD GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX -1.73420001 2.50E-08 4.44E-06 ERBB2/TRAV39/SCN2B/TGFBR1/KCNB2/ITGA1/SNAP25/CD3D/GNGT2/CACNB4/ATP6AP1L/EPS15/TRBJ2-5/CHRNE/TRBV20-1/EVC/SGCE/TRAV19/KCNA5/GJD3/ITGA9/TRAJ3/HLA-B/IL2RB/BMPR1B/CDH24/GNAI1/KCNJ2/TRBJ2-6/KCNB1/TRDC/GLRB/CD8A/TF/ITGB5/KCNMB1/KCNQ4/INSR/ACVR1C/TRBJ2-2/SNTA1/TRGV10/GNG7/LIN7B/GJC1/GRIK3/OLFM2/CD3E/HLA-DQB2/CASP10/KCNA4/CD79B/CACNA2D3/KCNA3/PSEN2/KCNMB4/SGCB/NEO1/GNG11/JUP/GJA4/HSPG2/HFE/FXYD1/KCNJ8/ATP1B1/SCN3A/SHANK3/KCNAB1/GNAZ/KCNK6/TRAF5/CDH8/ABCC9/CYBB/CDH19/KCNIP2/TRBC2/ERBB3/HLA-DQA1/HLA-DQB1/HLA-DMA/ATP1A2/CD74/SCN9A/ITGA8/CAV1/CALM1/TRAC/GNB4/ITGA7/DMD/ITGB8/CALCRL/HLA-DRA/HLA-DMB/HLA-DPA1/CAV2/KCNMA1/ACVRL1/SGCD/ITGBL1/KCNJ3/RAMP1/ATP1B2/GRIN2A/MPP7/HLA-DRB1/PGM5/HLA-DOA/HLA-DQA2/CNTFR/GRIA2/CDH2/GRIA1/IGF1/PLP1/C6/SCN4B/SGCG/SCN7A/ITGB4/CDH5/ITGA6/RAMP3/RAMP2/C7 GOBP_CELL_MATRIX_ADHESION -1.604107056 0.000183651 0.004838736 BCL2/ROCK2/EPB41L5/FERMT1/POSTN/VCL/ITGB5/THBS3/SEMA3E/FBLN5/TRIP6/PKD1/DUSP3/NPNT/L1CAM/CD3E/DAPK3/COL16A1/TMEM8B/SIGLEC1/FUT1/PTK2/JUP/CASK/DLC1/AJUBA/CLASP2/EPDR1/BCAM/BST1/RRAS/ILK/ITGA8/ITGA7/ACVRL1/ITGBL1/EPHA3/ECM2/THY1/THSD1/SFRP1/CD34/FREM1/MYOC/FAM107A/ACTN2/TEK/ITGB4/KDR/CCL21/APOD GOBP_B_CELL_MEDIATED_IMMUNITY -1.580204317 0.001281085 0.018823051 IGHV3-48/INPP5D/IGHV3-21/IGLV1-40/IGKC/IGHV3-30/IGKV1-12/CD40LG/TRDC/IGHV1-18/IGLV3-19/TREX1/IGHV3-49/MSH2/IGHG3/IGKV2-30/CD81/IGHV3-11/IGLC6/IGKV1-5/IGHV3-33/IGLV2-14/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/HLA-DQB1/CD74/IGHV3-23/IGKV3-20/IGHM/IGHV3-7/IGHG1/HLA-DRB1/CD55/C6/IGHG2/IGHA1/IGHA2/CFI/C3/C7 GOCC_ACTIN_CYTOSKELETON -1.731556844 5.12E-08 7.96E-06 SHROOM1/CAPN2/MYL3/ROR1/DCTN2/XIRP1/CGNL1/EZR/CLDN5/ANG/ABLIM2/OPHN1/PDLIM5/MYO1C/MYLK3/ARPC1A/MYL4/LMOD3/ACTR1B/TPM2/PPP1R12A/VCL/WIPF3/AMPH/MYOZ1/RCSD1/ARHGAP21/FSCN2/MYZAP/CALB2/MYH7/CNN3/DAAM1/TRIP6/SMTN/MYL6/LIMA1/SYNPO2L/DAPK3/SYNPO2/SNCA/MYADM/SPTAN1/SPTBN1/PTK2/KAT2B/ZNF185/JUP/CTTNBP2/CASK/ABRA/DCDC2C/MYL2/TNNC1/HFE/LMOD1/GAS7/MYLK/CALD1/DLC1/EPB41L2/FHOD3/TNNT2/MYO1D/LMOD2/AHNAK/CFL2/AIF1L/CRYAB/FLNB/DENND2A/TNNI3/MYL12A/MYL12B/MYL9/ILK/FSCN1/MYOT/FILIP1/AFAP1L1/MYO5B/MYH6/NEBL/PLS3/CNN2/ACTG2/MYL7/MYH11/STK38L/PPP1R9A/EPHA3/FLNA/PKD2/MYRIP/ACTN4/ABLIM1/PGM5/MYO5C/TMOD2/DSTN/PDLIM7/SORBS2/NEXN/CDH2/CLIC5/FLT1/TPM1/FAM107A/ACTN2/TEK/LDB3/ACTA2/MYH10/ACTC1 GOBP_CELL_SUBSTRATE_ADHESION -1.673845614 6.76E-06 0.000407832 SORBS3/BCL2/ROCK2/EPB41L5/LGALS1/SPOCK2/FERMT1/POSTN/VCL/ITGB5/THBS3/BVES/LAMC1/EPHB3/SEMA3E/FBLN5/TRIP6/PKD1/DUSP3/NOTCH1/NPNT/LAMA5/L1CAM/CD3E/DAPK3/COL16A1/TMEM8B/JAK2/MYADM/SIGLEC1/FUT1/PTK2/JUP/OLFM4/CASK/PTN/DLC1/AJUBA/CLASP2/NTN4/EPDR1/FZD4/PDGFB/BCAM/BST1/RRAS/ILK/ITGA8/ITGA7/ACVRL1/FZD7/ITGBL1/EPHA3/ATP1B2/FLNA/ANGPT1/ECM2/LIMS2/FBLN2/THY1/ACTN4/THSD1/GAS6/SFRP1/VIT/CD34/FREM1/FBLN1/MYOC/FAM107A/ACTN2/TEK/ITGB4/KDR/ITGA6/CCL21/VWF/APOD GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION -1.715167734 2.25E-07 2.42E-05 ERBB4/PRCP/MIR101-1/PTPRM/MIXL1/MIR23A/VASH1/AGTR2/SOX8/ROCK2/EPB41L5/TMSB4X/ISL1/GATA2/FERMT1/HAS1/PIK3R3/RHOJ/ACVR1C/STARD13/FGF18/SEMA3B/HYAL1/SOX9/EPB41L4B/PLEKHG5/SEMA3E/PIK3CG/NOTCH1/PROX1/ATOH8/LAMA5/FGF7/PLCG2/FUT1/WNT5A/PTK2/FLT4/JUP/HDAC5/PTN/CARD10/WNT11/SEMA6A/BMP4/STC1/CLASP2/SEMA3A/MMRN2/MIR410/PLK2/P2RY12/HYAL2/SMOC2/PFN2/PDGFB/SOX10/RRAS/SOX17/EDNRB/CTSH/PAK3/FSTL1/EFNB2/DPP4/MEF2C/SLIT2/ADGRA2/SPARC/PPARG/EDN1/NOS3/EPHB4/FGF10/KLF4/SOX18/ACVRL1/DLL4/SEMA3C/HBEGF/ANGPT1/MIR145/SLC8A1/HAND2/GPLD1/SEMA3D/CDH2/TGFB2/SCG2/AMOTL2/NR4A1/TEK/GPC3/ITGB4/ANXA3/CDH5/SEMA3G/KDR/RGCC/CLEC14A/SERPINF1/DCN GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS -1.639600855 7.59E-05 0.002667639 MYO1C/AGTR2/FBN2/SKIL/FERMT1/MIR17HG/BAMBI/PMEPA1/NREP/CDKN2B/FGF18/LTBP4/SLC2A10/VASN/NOTCH1/NPTN/CIDEA/WNT5A/NEO1/CASK/FSTL3/SEMA6A/BMP4/HTRA1/TOB1/MMRN2/IL17RD/TWSG1/FZD4/SMOC2/FST/CD109/DKK3/SORL1/TGFB1I1/CAV1/HTRA3/FSTL1/SLIT2/ADGRA2/PPARG/FGF10/CAV2/ACVRL1/HHEX/CDKN1C/RBPMS2/SOST/TSPAN12/RASL11B/SFRP1/CRIM1/GPC3/MIR140/LTBP1/ASPN/CDH5/SFRP2/SFRP4/DCN/CHRDL1 GOBP_REGIONALIZATION -1.631916307 0.000195966 0.004967388 TMEM107/CHRD/TGFBR1/C1QA/NR2F2/IFT172/TCF15/BMPR1B/SIX1/EPB41L5/ISL1/TBX20/ROR2/HOXB2/IRX1/EXT1/RARG/MDFI/ALDH1A2/NOTCH1/HOXB4/WNT5A/AR/HOXA2/HES4/HEY1/BHLHE41/WNT11/FGFR2/BMP4/CTNNBIP1/TCAP/HOXD8/HOXB3/SEMA3A/CYP26B1/SOX17/CXXC4/FOXC1/OSR1/MEF2C/HEY2/EDN1/FGF10/ACVRL1/DLL4/SEMA3C/HHEX/RELN/SFRP1/NKD1/EGR2/MEOX1/NRARP/GPC3/SFRP2/C3 GOBP_TISSUE_MIGRATION -1.670288909 1.11E-05 0.000595265 PRCP/MIR101-1/PTPRM/MIR23A/VASH1/AGTR2/ROCK2/EPB41L5/TMSB4X/GATA2/FERMT1/PIK3R3/RHOJ/STARD13/FGF18/HYAL1/SOX9/EPB41L4B/PLEKHG5/PIK3CG/NOTCH1/PROX1/ATOH8/FGF7/PLCG2/FUT1/WNT5A/PTK2/FLT4/JUP/HDAC5/PTN/CARD10/BMP4/STC1/CLASP2/SEMA3A/MMRN2/MIR410/PLK2/SMOC2/PFN2/PDGFB/RRAS/CTSH/FSTL1/EFNB2/DPP4/MEF2C/SLIT2/ADGRA2/SPARC/PPARG/EDN1/ACTG2/NOS3/EPHB4/FGF10/KLF4/SOX18/ACVRL1/DLL4/HBEGF/ANGPT1/GPLD1/TGFB2/SCG2/NR4A1/TEK/ACTA2/ANXA3/CDH5/KDR/RGCC/CLEC14A/ACTC1/SERPINF1/DCN GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE -1.690135445 3.88E-06 0.000262516 ADGRA3/BTN3A2/IGHV3-48/IL2RB/EPHA5/IGHV3-21/IGKC/IGHV3-30/CD40LG/TRDC/S1PR1/CD24/CD8A/CUBN/TF/IGHV1-18/RAET1E/IGHV3-49/INSR/SLC4A3/TRGV10/IGHG3/GFRA3/TLR4/IGHV3-11/IGLC6/STAB2/CD3E/ENOX2/AZGP1/CD79B/F10/BTN3A3/IL12RB2/HFE/SCUBE1/CXCL10/IGHV3-33/FCGRT/IL11RA/ACE/ENPEP/TRBC2/FOLR2/IGHG4/P2RY12/HYAL2/IGHV4-39/IGHV4-59/BCAM/CD74/IGHV3-23/F3/SLC2A4/CD248/NCAM1/CD1C/IGHM/IGHV3-7/KCNJ3/ATP1B2/HEG1/MCAM/THY1/IGHG1/HLA-DRB1/CXCL9/CA4/CNTFR/GRIA2/CD69/CD34/IL31RA/IGHG2/GPIHBP1/ACKR3/ABCG2/IGHA1/SELP/IGHA2/GFRA1/CX3CR1/CDH5/ACKR4/CLEC14A/SCARA5 GOBP_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION -1.561075994 0.003047336 0.034079744 DMTN/CORO2B/INPP5K/SVIL/HDAC6/MAP1B/CGNL1/STMN2/ARPIN/MDM1/TMSB4X/S1PR1/GMFG/LMOD3/PICK1/F11R/ADD3/LIMA1/KANK4/SNCA/MYADM/SPTAN1/SPTBN1/KAT2B/KANK3/LMOD1/DLC1/CLASP2/SHANK3/FHOD3/LMOD2/PFN2/MAP2/SLIT2/PPP1R9A/TMOD2/FRMD7/MYOC/CDH5 GOBP_BONE_DEVELOPMENT -1.589972897 0.000838638 0.013682508 EXT1/THBS3/FGF18/COMP/RARG/NAB1/SOX9/SPNS2/TRIM45/TAL1/ALPL/HOXB4/PDGFC/LEP/OSR2/RANBP3L/FGFR2/BMP4/STC1/MMP16/PTGER4/CYP26B1/ZMPSTE24/FOXC1/SCX/RARB/MEF2C/PLS3/RAB23/TMEM119/BMP6/LRRC17/FREM1/IGF1/MYOC/TEK/SFRP2/SFRP4 GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION -1.549193805 0.00365292 0.038893592 PRCP/MIR101-1/MIR23A/VASH1/AGTR2/TMSB4X/GATA2/PIK3R3/RHOJ/STARD13/FGF18/NOTCH1/JUP/HDAC5/CARD10/MMRN2/MIR410/PLK2/PDGFB/EFNB2/MEF2C/SLIT2/PPARG/NOS3/EPHB4/KLF4/SOX18/ACVRL1/DLL4/ANGPT1/GPLD1/NR4A1/CDH5/KDR/RGCC/CLEC14A GOMF_GROWTH_FACTOR_BINDING -1.552092088 0.00387824 0.040219742 COL5A1/IL10RA/INSR/ACVR1C/LTBP4/VASN/PXDN/FLT4/PTN/FGFR2/HTRA1/IL11RA/COL1A2/TWSG1/HYAL2/ERBB3/CD109/LTBP2/PDGFB/HTRA3/SORT1/KAZALD1/DUSP1/ACVRL1/IGFBPL1/IGFBP6/CRIM1/NTRK2/FLT1/TEK/LTBP1/ITGB4/KDR/ITGA6 GOBP_CELL_CELL_JUNCTION_ORGANIZATION -1.599838082 0.00131869 0.019008405 CLDN5/ANG/GJD3/CDH24/MYO1C/ROCK2/VCL/EXT1/PKP2/CADM1/F11R/GJC1/NLGN4X/ESAM/JUP/GJA4/WNT11/PARD6G/CLDN1/CDH8/CDH19/ACE/DSG2/CD9/CAV1/FSCN1/ARVCF/PRKCH/FLNA/HEG1/LIMS2/DSP/MPP7/BMP6/CDH2/TGFB2/CDH5/RAMP2/PECAM1 GOMF_CALMODULIN_BINDING -1.612280175 0.000922183 0.014577837 MYO1C/ATP2B1/ITPKB/CAMKK1/KCNQ4/CAMKK2/SNTA1/PDE1C/MYH7/CNN3/ADD3/RGS1/SPTAN1/SPTBN1/CASK/FBXL2/RYR2/MYLK/CALD1/UNC13C/MARCKSL1/MYO1D/ADCY1/PLCB1/RYR3/MAP2/MYO5B/MYH6/KCNN3/CNN2/NOS3/CAMK2G/MYH11/REM1/SLC8A1/TTN/AKAP5/MYO5C/CNN1/GEM/MYH10 GOBP_SYNAPSE_ASSEMBLY -1.59038701 0.001203976 0.017952805 PLXNB1/CLSTN1/MAP1B/ERBB4/FZD1/EEF2K/FLRT2/PCDHB4/CLSTN2/PDLIM5/SIX1/GPC6/SPOCK2/LRRN3/SLITRK3/FLRT3/OBSL1/AGRN/EPHB3/PCLO/CBLN1/NLGN4X/SLITRK1/SNCA/NPTN/DNER/WNT5A/NLGN3/LRRC4B/EPHA7/ADGRL3/SHANK3/PTPRD/BDNF/GPM6A/EFNB2/MEF2C/PPP1R9A/LRRN1/PCDH17/CDH2/NTRK2/LGI2/AMIGO2 GOBP_CELL_JUNCTION_ASSEMBLY -1.740543538 3.18E-07 3.15E-05 CLDN5/ERBB4/FZD1/EEF2K/GJD3/FLRT2/OPHN1/PCDHB4/CLSTN2/PDLIM5/CDH24/MYO1C/SIX1/BCL2/ROCK2/EPB41L5/RAPGEF1/GPC6/SPOCK2/LRRN3/VCL/SLITRK3/FLRT3/PKP2/OBSL1/LAMC1/AGRN/F11R/EPHB3/PCLO/GJC1/CBLN1/NLGN4X/TRIP6/DUSP3/SLITRK1/DAPK3/COL16A1/SNCA/NPTN/DNER/ESAM/WNT5A/PTK2/NLGN3/JUP/LRRC4B/GJA4/WNT11/PARD6G/EPHA7/ADGRL3/DLC1/AJUBA/CLASP2/SHANK3/CLDN1/CDH8/PTPRD/CDH19/ACE/BDNF/CD9/ILK/CAV1/FSCN1/GPM6A/EFNB2/MEF2C/ARVCF/PRKCH/ACVRL1/PPP1R9A/EPHA3/FLNA/HEG1/LIMS2/THY1/MPP7/LRRN1/THSD1/PCDH17/SFRP1/CDH2/NTRK2/LGI2/MYOC/FAM107A/ACTN2/TEK/AMIGO2/ITGB4/CDH5/KDR/ITGA6/RAMP2/PECAM1/APOD GOBP_REGULATION_OF_CELL_MATRIX_ADHESION -1.536148208 0.004355017 0.043163398 BCL2/ROCK2/EPB41L5/FERMT1/POSTN/VCL/SEMA3E/DUSP3/CD3E/DAPK3/COL16A1/FUT1/PTK2/JUP/CASK/DLC1/CLASP2/BST1/RRAS/ACVRL1/EPHA3/THY1/SFRP1/MYOC/FAM107A/TEK/KDR/CCL21/APOD GOBP_ENDOTHELIAL_CELL_PROLIFERATION -1.609480538 0.001090592 0.016571815 ALDH1A2/PROX1/ATOH8/VEGFB/FUT1/WNT5A/FLT4/LEP/BMP4/MIR410/PDGFB/CAV1/F3/MEF2C/SPARC/PPARG/CAV2/ACVRL1/DLL4/AGTR1/BMP6/TIE1/CD34/EGFL7/THBS4/SCG2/FLT1/PPP1R16B/NR4A1/TEK/NRARP/KDR/RGCC/APLNR/IGF2 GOBP_NEURON_PROJECTION_GUIDANCE -1.686435613 2.85E-05 0.001294026 GLI2/KIF5B/SCN1B/SEMA6B/EPHB6/SEMA5B/SEMA5A/ERBB2/GDF7/LAMB2/PLXNB1/EZR/PTPRM/FLRT2/OPHN1/EMB/BMPR1B/EPHA5/MYPN/ISL1/MAPK1/FLRT3/EXT1/PLXNB3/FEZ1/SEMA3B/GFRA3/EPHB3/BOC/CNTN4/SEMA3E/B3GNT2/UNC5C/NOTCH1/LAMA5/L1CAM/NPTN/SPTAN1/SPTBN1/WNT5A/PTK2/NEO1/PLXNA1/HOXA2/LGR6/LGI1/SEMA6A/EPHA7/SHANK3/NTN4/SEMA3A/ANOS1/BDNF/MYOT/EFNB2/SLIT2/NCAM1/EPHB4/SLIT3/SEMA3C/EPHA3/RELN/ROBO4/PDLIM7/SEMA3D/NEXN/EGR2/GFRA1/SEMA3G GOBP_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA -1.696804865 3.11E-05 0.001393295 ROCK2/EPB41L5/FBN2/SKIL/FERMT1/POSTN/ITGB5/MIR17HG/BAMBI/PPARGC1A/PMEPA1/NREP/CDKN2B/LTBP4/SLC2A10/F11R/CILP/SOX9/FMOD/VASN/WWOX/CIDEA/WNT5A/PTK2/PDE2A/FGFR2/HTRA1/PDGFD/CLDN1/COL1A2/IL17RD/TWSG1/GDF10/HYAL2/CD109/DKK3/LTBP2/TGFB1I1/CAV1/HTRA3/SCX/MEF2C/ITGB8/EDN1/CAV2/ACVRL1/CDKN1C/RASL11B/SFRP1/JUN/TGFB2/MXRA5/LEFTY2/CLEC3B/LTBP1/CX3CR1/ASPN/CDH5/FOS GOMF_ACTIN_FILAMENT_BINDING -1.651769176 0.000169812 0.004610865 POF1B/DMTN/LASP1/CORO2B/SVIL/CTTN/SHROOM1/XIRP1/EZR/ABLIM2/MYO1C/ARPC1A/CTNNAL1/MYL4/TPM2/PICK1/FERMT1/RCSD1/FSCN2/MYH7/ADD3/LIMA1/MYOM2/TAGLN/ZNF185/TNNC1/NRAP/GAS7/AJUBA/MARCKSL1/FHOD3/CORO6/MYO1D/CFL2/AIF1L/TNNI3/CTNNA3/FSCN1/SYNE1/MYO5B/MYH6/NEBL/PLS3/MYH11/PPP1R9A/FLNA/ACTN4/ABLIM1/TTN/MYOM1/MYO5C/DSTN/NEXN/TPM1/ACTN2/MYH10 GOMF_PROTEIN_TYROSINE_KINASE_ACTIVITY -1.583432901 0.002357317 0.029301195 MAP2K5/EPHB6/ITK/FES/NEK1/MAP2K4/ERBB2/CLK1/DYRK2/CLK4/ERBB4/EPHA5/ROR2/BMX/CAMKK2/INSR/EPHB3/MAP2K6/FRK/JAK2/PTK2/FLT4/FGFR2/WEE1/PDGFRL/EPHA7/ERBB3/PKDCC/EPHB4/EPHA3/TTN/TIE1/CRIM1/NTRK2/FLT1/TEK/KDR GOCC_POSTSYNAPTIC_MEMBRANE -1.656538486 0.000214827 0.005300764 PTPRS/GABBR1/SLITRK2/SSPN/GRID1/MX1/MX2/LRRC4/KCND2/TIAM1/ABHD17B/DNM1/CLSTN1/CHRNE/ERBB4/CNKSR2/CLSTN2/RGS9/KCNB1/IGSF9B/GRIP1/GLRB/SLITRK3/FLRT3/KCTD12/SNTA1/LIN7B/CBLN1/NLGN4X/GABRA4/SLITRK1/GRIK3/NPTN/GABRB1/KCNA3/NLGN3/CNTN1/LRRC4B/ARRB1/EPHA7/SHANK3/ADCY1/SYNE1/DMD/PRRT2/KCNMA1/ADAM22/GRIN2A/SHC4/SLC8A1/GRIA2/PCDH17/CDH2/GRIA1/RGS7BP/ACTN2/GSG1L GOBP_INOSITOL_LIPID_MEDIATED_SIGNALING -1.644159243 0.000219929 0.005362826 PPP2R5B/ERBB2/SIRT2/PLXNB1/ROR1/EZR/ERBB4/CAT/PLCD3/ROR2/NLRC3/PLCD1/MAPK1/INSR/SOX9/PIK3CG/GPER1/PREX2/PLD1/PDGFC/JAK2/PTPN13/PTK2/LEP/CCL5/PIK3IP1/NCS1/FBXL2/PDGFD/PIK3C2B/ERBB3/PDGFB/PLCB1/EDN1/KLF4/ANGPT1/PLCB4/TGFB2/IGF1/NPR3/NTRK2/FLT1/MYOC/PPP1R16B/SELP/TEK/KDR/DCN GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION -1.647317463 0.000206799 0.005143514 PRCP/MIR101-1/PTPRM/MIR23A/VASH1/AGTR2/ROCK2/TMSB4X/GATA2/RHOJ/STARD13/FGF18/PIK3CG/NOTCH1/PROX1/ATOH8/FUT1/WNT5A/PTK2/FLT4/JUP/HDAC5/PTN/CARD10/BMP4/STC1/MMRN2/MIR410/PLK2/SMOC2/PDGFB/RRAS/MEF2C/SLIT2/ADGRA2/SPARC/PPARG/EDN1/NOS3/KLF4/ACVRL1/DLL4/ANGPT1/GPLD1/TEK/ANXA3/KDR/RGCC/SERPINF1/DCN GOBP_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION -1.735403344 3.97E-06 0.00026323 ATP2B1/BCL2/GSTM2/S1PR1/CD24/GATA2/P2RY10/GPR174/F2RL2/GPR4/FAM155B/GPR20/TACR1/MCOLN3/CALB2/CALM2/PKD1/PIK3CG/GPER1/CXCL11/BOK/RIC3/JAK2/SNCA/NPTN/PLCG2/WNT5A/TRPC1/NCS1/RYR2/CXCL10/ADCY5/CASQ1/HRC/ESR1/ADRA1D/PTGER4/CYSLTR1/JPH2/ADRA1B/TRPC6/RYR3/ATP1A2/CAV1/EDNRB/LPAR4/CALM1/CCL3/DMD/EDN1/CAV2/AGTR1/PKD2/GRIN2A/SLC8A1/THY1/AVPR1A/CLIC2/PTGFR/CXCL9/CCL19/PLN/CD55/GRIA1/ACKR3/CX3CR1/ACKR4/CASQ2/RAMP3/APLNR/CCL21 GOBP_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING -1.618030856 0.001303386 0.018936871 PPP2R5B/ERBB2/SIRT2/PLXNB1/ROR1/ERBB4/CAT/ROR2/NLRC3/MAPK1/INSR/SOX9/PIK3CG/GPER1/PREX2/PDGFC/JAK2/PTPN13/PTK2/LEP/CCL5/PIK3IP1/FBXL2/PDGFD/PIK3C2B/ERBB3/PDGFB/EDN1/KLF4/ANGPT1/TGFB2/IGF1/NTRK2/FLT1/MYOC/PPP1R16B/SELP/TEK/KDR/DCN GOBP_SPROUTING_ANGIOGENESIS -1.61899714 0.001228797 0.01823546 PIK3R3/RHOJ/STARD13/MIR30E/SEMA3E/NOTCH1/VEGFB/FUT1/FLT4/HDAC5/CARD10/SEMA6A/BMP4/MMRN2/MIR410/PLK2/S100A1/EFNB2/SLIT2/ADGRA2/EPHB4/KLF4/ACVRL1/DLL4/AGTR1/ANGPT1/RSPO3/GPLD1/PPP1R16B/NR4A1/TEK/NRARP/KLF2/KDR/CLEC14A/APLNR/RAMP2 GOMF_LIPID_TRANSPORTER_ACTIVITY -1.624012899 0.001250983 0.018477038 SLC25A13/ANO6/ATP8B1/SLC1A7/SLC27A6/SLC10A6/PLEKHA8P1/GM2A/SPNS2/ATP10A/ATP9A/OSBPL1A/ABCA6/OSBPL3/SLC1A4/ABCD2/ATP8B2/RBP4/PLSCR4/ABCA3/ATP8A1/MTTP/ABCA9/ABCA8/TMEM30B/SLC10A4/APOB/ABCA10/SLCO2A1/FABP3/FABP4/APOD GOBP_ENDOTHELIAL_CELL_MIGRATION -1.722255103 2.29E-05 0.001113159 PRCP/MIR101-1/PTPRM/MIR23A/VASH1/AGTR2/ROCK2/TMSB4X/GATA2/PIK3R3/RHOJ/STARD13/FGF18/PLEKHG5/PIK3CG/NOTCH1/PROX1/ATOH8/FUT1/WNT5A/PTK2/FLT4/JUP/HDAC5/PTN/CARD10/BMP4/STC1/MMRN2/MIR410/PLK2/SMOC2/PDGFB/RRAS/FSTL1/EFNB2/DPP4/MEF2C/SLIT2/ADGRA2/SPARC/PPARG/EDN1/NOS3/EPHB4/KLF4/SOX18/ACVRL1/DLL4/ANGPT1/GPLD1/SCG2/NR4A1/TEK/ANXA3/CDH5/KDR/RGCC/CLEC14A/SERPINF1/DCN GOBP_NON_CANONICAL_WNT_SIGNALING_PATHWAY -1.662922557 0.0004509 0.009192442 SFRP5/TIAM1/TNRC6A/VANGL1/DAAM2/ROR1/FZD1/VANGL2/CCDC88C/GPC6/ROR2/DAAM1/WNT5A/WNT11/FZD2/AGO4/FZD6/FZD8/FZD4/PLCB1/PRICKLE1/CALM1/FZD7/DACT1/RSPO3/FRZB/SFRP1/NKD1/ANKRD6/CTHRC1/MYOC/GPC3/SFRP2/SFRP4 GOBP_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY -1.791085165 2.11E-07 2.35E-05 FBN2/TBX20/ROR2/SKIL/TF/FERMT1/ITGB5/MIR17HG/BAMBI/EXT1/PMEPA1/ACVR1C/NREP/CDKN2B/COMP/LTBP4/SLC2A10/F11R/CILP/FMOD/VASN/NOTCH1/ATOH8/JAK2/CIDEA/INHBB/WNT5A/PTK2/NEO1/VIM/FSTL3/HFE/BMP4/HTRA1/TOB1/COL1A2/IL17RD/TWSG1/GDF10/FST/CD109/DKK3/LTBP2/SORL1/TGFB1I1/CAV1/HTRA3/SCX/FSTL1/TMEM100/PPARG/ITGB8/FGF10/CAV2/ACVRL1/CDKN1C/RBPMS2/SOST/RASL11B/BMP6/SFRP1/JUN/TGFB2/CRIM1/LEFTY2/GPC3/MIR140/LTBP1/ASPN/CDH5/SFRP2/SFRP4/FOS/CHRDL1 GOBP_HEART_DEVELOPMENT -1.872119534 1.00E-10 3.66E-08 CLDN5/ERBB4/TAZ/MIXL1/FLRT2/ZFPM2/MIR23A/KDM6A/PDLIM5/MYLK3/VANGL2/AGTR2/SIX1/ROCK2/VGLL4/ISL1/S1PR1/TBX20/MAPK1/TREX1/ADAMTS6/COL5A1/MIR17HG/FLRT3/EXT1/GALNT11/ALPK2/PKP2/INSR/ZBTB14/OBSL1/BVES/POPDC2/LMO4/SOX9/GJC1/MYH7/PKD1/ALDH1A2/NOTCH1/GPER1/PROX1/SYNPO2L/ID3/VEGFB/WNT5A/PTK2/KAT2B/SGCB/PDE2A/PAM/CSRP3/HEY1/PTN/MYL2/WNT11/FZD2/TNNC1/FGFR2/SCUBE1/NRAP/RYR2/KCNJ8/FHL2/BMP4/DLC1/MYBPC3/TCAP/TBX5/KCNAB1/FHOD3/TNNT2/DSG2/TNNI3/ERBB3/OLFM1/JPH2/RBP4/PDGFB/FGF12/SOX17/ZMPSTE24/PRICKLE1/FOXC1/SCX/OSR1/RARB/EFNB2/MEF2C/SLIT2/MYH6/SPARC/TMEM100/NEBL/NPY5R/PPARG/HEY2/RBM24/EDN1/NOS3/EPHB4/CALCRL/MYH11/SLIT3/SOX18/ACVRL1/FZD7/SGCD/DLL4/SEMA3C/FLNA/PKD2/ELN/HEG1/MIR145/SLC8A1/DSP/CRIP1/TTN/ACACB/PDLIM7/SORBS2/HAND2/PLN/OXCT1/ADGRG6/NPPA/TIE1/TGFB2/IGF1/TPM1/SGCG/ACTN2/TEK/GPC3/NPY1R/LDB3/SFRP2/APLNR/ACTC1/RAMP2/PI16 GOBP_EAR_DEVELOPMENT -1.659651903 0.000795814 0.013160564 IFT27/INSIG1/NAGLU/ROR1/TCF15/HESX1/ATP8B1/SIX1/BCL2/ROR2/GATA2/MAPK1/KCNQ4/MCOLN3/SOX9/NOTCH1/CEBPA/PROX1/WNT5A/HOXA2/OSR2/ALDH1A3/FZD2/FGFR2/MAF/BMP4/TCAP/LGR5/JAG2/FZD6/LRIG3/OSR1/SPARC/HEY2/EDN1/FGF10/FRZB/TGFB2/CTHRC1/CYTL1/CXCL14 GOBP_REGULATION_OF_SYSTEM_PROCESS -1.864388691 3.35E-10 1.10E-07 SCN2B/KCNB2/JAM2/CACNB4/MYL3/ADA/ADRB1/SGK1/MEF2A/CYP2J2/CRY1/KCNA5/GJD3/IGSF11/DOCK4/TNNI3K/PER2/KCNJ2/AGTR2/ATP2B1/GSTM2/ROCK2/TRIM63/ISL1/MYL4/MIR17HG/TMEM25/PKP2/PPARGC1A/TACR1/SLC4A3/SNTA1/BVES/POPDC2/NPPB/MIR30E/CST7/THRA/GJC1/CALM2/MYH7/CBLN1/NLGN4X/PIK3CG/NOTCH1/MLIP/GPER1/DAPK3/JAK2/LRRK2/LMNA/CACNA2D3/INHBB/NLGN3/KCNMB4/LEP/JUP/CSRP3/MYL2/TRPC1/TNNC1/RYR2/FXYD1/ATP1B1/ADRA2B/MYBPC3/STC1/SHANK3/KCNK6/TNNT2/CASQ1/HRC/SEMA3A/STK39/ABCC9/ADRA2A/ADRB2/ACE/KCNIP2/ADRA1D/DSG2/TNNI3/CTNNA3/PDGFB/NPTXR/ADRA1B/SOX10/FGF12/SLN/RYR3/MYL9/ATP1A2/ZMPSTE24/CAV1/EDNRB/GLS/S100A1/CALM1/CCL3/MYH6/TMEM100/DMD/HEY2/MGLL/EDN1/NOS3/CALCRL/FGF10/CAMK2G/DMPK/KLF4/KCNMA1/NPR1/KCNJ3/ATP1B2/AGTR1/HBEGF/FLNA/FXYD6/RELN/MIR145/NR4A3/SLC8A1/DSP/AVPR1A/CLIC2/GPD1L/HAND2/GAS6/BMP6/PLN/NPPA/EHD3/EGR2/TGFB2/IGF1/SCN4B/CNN1/TPM1/THRB/ADIPOQ/CASQ2/DES/PI16 GOBP_NEPHRON_DEVELOPMENT -1.624555205 0.003930147 0.040526794 AGTR2/SIX1/SOX8/KLF15/BCL2/CD24/IRX1/COL4A3/GPR4/EXT1/SOX9/PKD1/NOTCH1/NPNT/LAMA5/KLHL3/WNT11/BMP4/CTNNBIP1/PDGFD/ENPEP/PDGFB/FOXC1/OSR1/MEF2C/ANGPT1/PKD2/CD34/TEK/PROM1/GPC3/ADIPOQ/ACTA2/PODXL/PECAM1 GOBP_CIRCULATORY_SYSTEM_PROCESS -1.894841602 1.00E-10 3.66E-08 SCN2B/ITGA1/NR2F2/CACNB4/MYL3/ADA/ADRB1/SLC2A13/SGK1/MEF2A/CYP2J2/CLDN5/PRCP/MME/TAZ/KCNA5/GJD3/DOCK4/TNNI3K/MIR23A/PER2/MYLK3/KCNJ2/AGTR2/ATP2B1/GSTM2/ROCK2/ISL1/TBX20/SLC16A12/HOXB2/COL4A3/MYL4/TREX1/GPR4/POSTN/EXT1/PKP2/INSR/SLC4A3/COMP/SNTA1/BVES/POPDC2/SLC2A10/F11R/NPPB/MIR30E/THRA/XCL2/GJC1/CALM2/MYH7/MAP2K6/PIK3CG/GPER1/CTSG/VEGFB/BBS2/JAK2/SLC22A3/CACNA2D3/KCNMB4/LEP/JUP/AR/PDE2A/CSRP3/MYL2/TRPC1/TNNC1/RYR2/FXYD1/KCNJ8/ATP1B1/CXCL10/SLC1A4/ADRA2B/MYBPC3/CTNNBIP1/STC1/TCAP/DDAH1/KCNK6/TNNT2/CASQ1/SUCNR1/HRC/SEMA3A/STK39/COL1A2/ABCC9/ADRA2A/ADRB2/ACE/KCNIP2/ENPEP/ADRA1D/DSG2/TNNI3/CTNNA3/PDGFB/ADRA1B/FGF12/RYR3/ATP1A2/ZMPSTE24/CAV1/EDNRB/S100A1/CALM1/FOXC1/SLC2A4/CES1/SLIT2/MYH6/PPARG/DMD/HEY2/EDN1/NOS3/DMPK/ATP8A1/RARRES2/KCNMA1/ACVRL1/SGCD/DLL4/NPR1/KCNJ3/ATP1B2/AGTR1/HBEGF/FLNA/FXYD6/ANGPT1/ELN/HEG1/SLC8A1/DSP/AVPR1A/TTN/CLIC2/GPD1L/GAS6/BMP6/PLN/HBB/NPPA/EHD3/CD34/TGFB2/SCN4B/NPR3/TPM1/ABCG2/SGCG/THRB/TEK/NPY1R/ADIPOQ/KLF2/ACTA2/CDH5/CASQ2/RAMP3/ACTC1/DES/RAMP2 GOMF_HEPARIN_BINDING -1.666409993 0.000689936 0.011949926 SOD3/FGF9/GREM2/ANG/CRISPLD2/EFEMP2/IMPG2/CCL8/POSTN/COL5A1/THBS3/COMP/PCOLCE2/ADAMTSL5/ADAMTS5/CXCL11/CTSG/FGF7/VEGFB/PRELP/RSPO1/LGR6/PTN/FGFR2/RSPO2/NELL2/CXCL10/BMP4/COL25A1/ANOS1/SMOC2/LTBP2/COLQ/SELL/FSTL1/SLIT2/FGF10/SLIT3/HBEGF/RSPO3/ECM2/SOST/TNXB/SFRP1/THBS4/APOB/SELP/CLEC3B/LPL GOBP_CALCIUM_ION_TRANSPORT -1.830526816 9.33E-08 1.14E-05 CRACR2B/CALM2/PKD1/PIK3CG/GPER1/CXCL11/TMEM37/SNCA/PLCG2/CACNA2D3/PSEN2/GJA4/CCL5/TRPC1/NCS1/RYR2/ATP1B1/CXCL10/MYLK/SMDT1/STC1/CASQ1/HRC/AHNAK/ADRA2A/CYSLTR1/P2RY12/IL16/JPH2/PDGFB/TRPC6/SLN/RYR3/ATP1A2/ZMPSTE24/CAV1/CALM1/GPM6A/CCL3/DMD/CALCRL/TSPAN13/CAMK2G/WFS1/REM1/RAMP1/PKD2/GRIN2A/SLC8A1/THY1/CLIC2/CXCL9/CCL19/GAS6/PLN/NPPA/EHD3/PLP1/SLC24A4/GEM/CASQ2/RAMP3/APLNR/RAMP2/CCL21 GOMF_CATION_CHANNEL_ACTIVITY -1.736696443 4.71E-05 0.001890551 KCNK7/SCN3B/ANO10/KCNK2/SCN5A/ANXA6/SCNN1D/TRPV1/TMEM38A/TRPM4/KCNC4/KCNH2/KCNS3/ANO1/SCN1B/HVCN1/KCNJ12/KCND2/KCNMB2/MCU/SCNN1B/NALCN/SCN2B/KCNB2/TRPM6/SNAP25/CACNB4/CHRNE/ANO6/KCNA5/KCNJ2/KCNB1/KCNMB1/FAM155B/KCNQ4/MCOLN3/KCNK5/PKD1/GRIK3/KCNA4/TMEM37/CACNA2D3/KCNA3/KCNMB4/TRPC1/TMEM175/NCS1/RYR2/KCNJ8/SCN3A/KCNAB1/KCNK6/KCNK17/ABCC9/KCNIP2/TRPC6/RYR3/SCN9A/GPM6A/KCNN3/KCNMA1/KCNJ3/PKD2/GRIN2A/GRIA2/GRIA1/SLC24A4/SCN4B/SCN7A GOBP_REGULATION_OF_BLOOD_PRESSURE -1.681558969 0.000537956 0.010345831 LEP/AR/ADRA2B/DDAH1/KCNK6/SUCNR1/STK39/COL1A2/ADRB2/ACE/ENPEP/ADRA1D/TNNI3/PDGFB/ADRA1B/ATP1A2/EDNRB/CES1/MYH6/PPARG/EDN1/NOS3/RARRES2/ACVRL1/NPR1/AGTR1/AVPR1A/GAS6/HBB/NPPA/CD34/NPR3/TPM1/NPY1R/ADIPOQ/ACTA2/RAMP2 GOBP_REGULATION_OF_MEMBRANE_POTENTIAL -1.833302065 8.30E-08 1.08E-05 TMEM25/PKP2/SLC4A3/KCNK5/SNTA1/BVES/POPDC2/GJC1/CBLN1/NLGN4X/WWP2/GABRA4/TUSC2/PID1/GRIK3/GPER1/BOK/LRRK2/GABRB1/ARL6IP5/NLGN3/KCNMB4/JUP/PTN/IFI6/RYR2/FXYD1/KCNJ8/KCTD7/ATP1B1/SCN3A/SHANK3/RIMS3/KCNK6/KCNK17/ADRB2/KCNIP2/DSG2/CTNNA3/FGF12/ATP1A2/SCN9A/ZMPSTE24/CAV1/CALM1/MEF2C/RIMS4/DMD/EDN1/DMPK/KCNMA1/PPP1R9A/KCNJ3/ATP1B2/FLNA/RELN/GRIN2A/SLC8A1/DSP/GPD1L/PLN/NPPA/EHD3/JUN/GRIA1/SCN4B/FHL1/RGS7BP/NTRK2/MYOC/ACTN2/SCN7A/KDR/CASQ2/DCN GOBP_BONE_MINERALIZATION -1.604694218 0.004103152 0.04155277 GPM6B/ANO6/BMPR1B/ATP2B1/S1PR1/FBN2/ROR2/KL/COMP/ISG15/ZBTB40/SOX9/LEP/OSR2/PTN/WNT11/FGFR2/RSPO2/BMP4/COL1A2/ADRB2/ZMPSTE24/OSR1/MEF2C/CCL3/PKDCC/SLC8A1/TMEM119/BMP6/IGF1/OMD/GPC3/CLEC3B/ASPN GOBP_APPENDAGE_MORPHOGENESIS -1.634201914 0.002211897 0.028124792 BMPR1B/FBN2/ROR2/EXT1/RARG/SOX9/ALDH1A2/NOTCH1/WNT5A/OSR2/FGFR2/RSPO2/BMP4/TBX5/FZD6/CYP26B1/OSR1/RARB/PKDCC/CRABP2/FGF10/SEMA3C/AFF3/HAND2/TGFB2/GPC3/SFRP2 GOBP_MEMBRANE_INVAGINATION -1.663702039 0.002325185 0.029090541 ELMO1/ANO6/SNX18/IGHV3-48/IGHV3-21/IGKC/ARHGAP12/IGHV3-30/TRDC/GATA2/IGHV1-18/IGHV3-49/ARHGAP25/IGHG3/IGHV3-11/IGLC6/ALKBH4/IGHV3-33/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGHV3-23/PPARG/IGHM/IGHV3-7/MEGF10/IGHG1/RHOBTB1/IGHG2/IGHA1/IGHA2/C3 GOBP_POTASSIUM_ION_TRANSPORT -1.717893081 0.000172454 0.004642087 AKAP9/ATP12A/TMEM38A/KCNC4/SLC9A6/KCNH2/KCNS3/ALG10B/KIF5B/CAB39/ATP1A3/KCNJ12/KCND2/KCNMB2/WNK2/NALCN/KCNB2/SNAP25/ANO6/KCNA5/KCNJ2/KCNB1/KCNMB1/KCNQ4/KCNK5/WWP2/KCNA4/KCNA3/KCNMB4/TMEM175/FXYD1/SLC12A4/KCNJ8/ATP1B1/KCNAB1/KCNK6/KCNK17/STK39/ABCC9/ADRA2A/KCNIP2/P2RY12/ATP1A2/CAV1/KCNN3/KCNMA1/KCNJ3/ATP1B2/FLNA/PKD2/NPPA/SLC24A4/FHL1/ACTN2/CASQ2 GOCC_TRANSPORTER_COMPLEX -1.778180326 6.27E-06 0.000385935 SCN3B/TMEM30A/ANO2/MICU1/NLGN1/KCNK2/SCN5A/SCNN1D/AKAP9/ATP12A/MICU2/TRPM4/SESTD1/TIMM10B/KCNC4/KCNH2/KCNS3/ANO1/LRRC8D/SCN1B/CLIC6/ATP1A3/KCND2/KCNMB2/MCU/SCNN1B/ABCA2/CTTN/CLIC3/SCN2B/KCNB2/SNAP25/CACNB4/CHRNE/ANO6/KCNA5/ATP8B1/KCNJ2/KCNB1/GLRB/MICU3/KCNMB1/KCNQ4/CALM2/PKD1/GABRA4/GRIK3/OLFM2/ATP10A/KCNA4/CACNA2D3/GABRB1/KCNA3/KCNMB4/TRPC1/RYR2/FXYD1/KCNJ8/ATP1B1/SMDT1/SCN3A/SHANK3/KCNAB1/KCNK6/ABCC9/KCNIP2/TRPC6/RYR3/ATP1A2/SCN9A/CALM1/ATP8A1/KCNMA1/KCNJ3/ATP1B2/PKD2/GRIN2A/CLIC2/PLN/GRIA2/GRIA1/SCN4B/CLIC5/SCN7A/CASQ2 GOMF_GLYCOSAMINOGLYCAN_BINDING -1.750386055 3.22E-05 0.001430705 GREM2/ANG/CRISPLD2/EFEMP2/IMPG2/CCL8/SPOCK2/POSTN/COL5A1/THBS3/COMP/LTBP4/AGRN/PCOLCE2/ADAMTSL5/ADAMTS5/CXCL11/STAB2/CTSG/FGF7/VEGFB/NLRP3/TNFAIP6/PRELP/RSPO1/LGR6/PTN/FGFR2/RSPO2/NELL2/CXCL10/BMP4/COL25A1/SUSD5/ANOS1/HYAL2/SMOC2/LTBP2/COLQ/PODXL2/SELL/FSTL1/SLIT2/ACAN/HAPLN1/FGF10/IGHM/SLIT3/HBEGF/RSPO3/ECM2/SOST/TNXB/SFRP1/VIT/THBS4/APOB/SELP/CLEC3B/LPL/JCHAIN/DCN GOBP_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING -1.655467173 0.002410463 0.02962106 ROR2/NLRC3/MAPK1/INSR/SOX9/PIK3CG/GPER1/PDGFC/JAK2/PTPN13/PTK2/LEP/CCL5/PIK3IP1/FBXL2/PDGFD/ERBB3/PDGFB/KLF4/ANGPT1/TGFB2/IGF1/NTRK2/FLT1/MYOC/PPP1R16B/SELP/TEK/KDR/DCN GOBP_APPENDAGE_DEVELOPMENT -1.713710212 0.000338705 0.007338208 FBN2/ROR2/EXT1/COMP/RARG/SOX9/ALDH1A2/NOTCH1/WNT5A/KAT2B/PAM/OSR2/FGFR2/RSPO2/BMP4/TBX5/FZD6/CYP26B1/SCX/OSR1/RARB/PKDCC/CRABP2/FGF10/SEMA3C/AFF3/HAND2/TGFB2/GPC3/ITGB4/SFRP2/ITGA6 GOCC_SARCOLEMMA -1.690793477 0.000555126 0.010519472 SGCE/EZR/SLC27A6/KCNJ2/KCNB1/VCL/SNTA1/BVES/POPDC2/MLIP/SGCB/RYR2/FXYD1/KCNJ8/ATP1B1/CASQ1/SYNM/AHNAK/RYR3/ATP1A2/CAV1/MYOT/SLC2A4/DMD/CAV2/SGCD/KCNJ3/SLC8A1/PGM5/DYSF/CDH2/SYNC/SGCG/DES GOBP_PLATELET_DEGRANULATION -1.671424433 0.001750094 0.023812003 APOOL/CD109/F13A1/PDGFB/CD9/CALM1/SPARC/F8/PCDH7/RARRES2/FLNA/ACTN4/ISLR/TTN/GAS6/TGFB2/IGF1/ACTN2/SELP/LEFTY2/CLEC3B/TIMP3/IGF2/PECAM1/MMRN1/CFD/VWF GOBP_EMBRYONIC_APPENDAGE_MORPHOGENESIS -1.618015231 0.002724084 0.03166047 FBN2/ROR2/RARG/ALDH1A2/NOTCH1/WNT5A/OSR2/RSPO2/BMP4/TBX5/FZD6/CYP26B1/OSR1/RARB/CRABP2/AFF3/HAND2/TGFB2/GPC3/SFRP2 GOMF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY -1.637577879 0.00274476 0.031841261 ATP12A/TMEM38A/KCNC4/SLC9A6/KCNH2/KCNS3/ATP1A3/KCNJ12/KCND2/KCNMB2/KCNB2/SNAP25/KCNA5/KCNJ2/KCNB1/KCNMB1/KCNQ4/KCNK5/GRIK3/KCNA4/KCNA3/KCNMB4/TMEM175/SLC12A4/KCNJ8/KCNAB1/KCNK6/KCNK17/ABCC9/KCNIP2/ATP1A2/KCNN3/KCNMA1/KCNJ3/PKD2/SLC24A4 GOBP_REGULATION_OF_TRANSMEMBRANE_TRANSPORT -1.936474118 1.00E-10 3.66E-08 MEF2A/ANO6/RGN/COX17/KCNA5/MIR103A1/PTPN3/PRKAG2/RGS9/ISCU/PER2/KCNJ2/KLF15/BCL2/KCNB1/GSTM2/TMSB4X/C2CD5/SLC43A1/KCNMB1/KCNQ4/PPARGC1A/INSR/KCNK5/SNTA1/TMEM109/TCAF1/CALM2/PIK3CG/WWP2/PID1/GPER1/CXCL11/KCNA4/TMEM37/SNCA/PLCG2/CACNA2D3/ARL6IP5/KCNA3/NLGN3/PSEN2/LEP/ACSL5/TRPC1/PM20D1/RYR2/FXYD1/KCNJ8/ATP1B1/CXCL10/SCN3A/SHANK3/KCNAB1/KCNK6/CASQ1/HRC/AHNAK/KCNK17/STK39/ADRA2A/CYBB/ADRB2/KCNIP2/JPH2/TRPC6/FGF12/SLN/ATP1A2/SCN9A/ZMPSTE24/CAV1/CALM1/OSR1/MEF2C/DMD/EDN1/TSPAN13/KCNMA1/REM1/KCNJ3/ATP1B2/FLNA/FXYD6/PKD2/RELN/GRIN2A/NR4A3/SLC8A1/THY1/ACTN4/CLIC2/CXCL9/GPD1L/PLN/GRIA2/NPPA/EHD3/GRIA1/IGF1/PLP1/SCN4B/FHL1/CLIC5/ACTN2/GPC3/SCN7A/GSG1L/ADIPOQ/GEM/CASQ2/RAMP3/APLNR/ITLN1/C3 GOBP_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY -1.807886934 3.73E-06 0.000257954 FBN2/TBX20/SKIL/FERMT1/MIR17HG/BAMBI/PMEPA1/NREP/CDKN2B/LTBP4/SLC2A10/CILP/VASN/NOTCH1/JAK2/CIDEA/INHBB/WNT5A/NEO1/FSTL3/HFE/BMP4/HTRA1/TOB1/IL17RD/TWSG1/GDF10/FST/CD109/DKK3/SORL1/TGFB1I1/CAV1/HTRA3/FSTL1/PPARG/FGF10/CAV2/ACVRL1/CDKN1C/RBPMS2/SOST/RASL11B/BMP6/SFRP1/TGFB2/CRIM1/LEFTY2/GPC3/MIR140/LTBP1/ASPN/CDH5/SFRP2/SFRP4/CHRDL1 GOMF_ACTIN_BINDING -1.930266307 1.00E-10 3.66E-08 PDLIM2/DIXDC1/POF1B/COBL/DMTN/LASP1/TNNT3/CORO2B/CCR5/SVIL/CTTN/LIMCH1/DAAM2/SHROOM1/INF2/MYL3/IMPACT/HDAC6/MAP1B/XIRP1/MAP1A/MICAL3/EZR/ANG/KLHL4/ABLIM2/OPHN1/VASH1/PDLIM5/MYO1C/MYPN/TMSB4X/ARPC1A/CTNNAL1/GMFG/RAI14/MYL4/LMOD3/PHACTR2/TPM2/PICK1/FERMT1/VCL/CCDC88A/WIPF3/MYOZ1/RCSD1/FSCN2/EPS8L2/SNTA1/MYH7/CNN3/DAAM1/SMTN/ADD3/LIMA1/DIAPH3/SYNPO2L/COBLL1/SYNPO2/MYOM2/SNCA/LRRK2/ALKBH4/TAGLN/SPTAN1/SPTBN1/PTK2/ZNF185/S100A4/CSRP3/ABRA/KLHL3/MYL2/TNNC1/NRAP/RUSC1/LMOD1/GAS7/MYLK/CALD1/MYBPC3/EPB41L2/AJUBA/MARCKSL1/SHANK3/FHOD3/TNNT2/CORO6/MYO1D/LMOD2/CFL2/AIF1L/FLNB/TNNI3/PFN2/CTNNA3/TRPC6/NCALD/FSCN1/SYNE1/MYOT/MYO5B/MYH6/NEBL/PLS3/DMD/CNN2/NOS3/MYH11/STK38L/KCNMA1/PPP1R9A/FLNA/MYRIP/CAP2/ACTN4/ABLIM1/TTN/MYOM1/MYO5C/TMOD2/DSTN/PDLIM7/NEXN/CNN1/TPM1/FAM107A/ACTN2/LDB3/MYH10 GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION -1.715722031 0.000391816 0.008286767 TGFBR1/NR2F2/MCC/IFT172/CDK6/MIR181B1/RGN/PTPRM/VASH1/ISL1/COL4A3/NLRC3/CDKN2B/SOX9/MIR30E/ATOH8/WNT5A/AR/CASK/PTN/FGFR2/BMP4/MIR410/CD109/CAV1/MEF2C/SPARC/PPARG/CAV2/DLL4/CDKN1C/LIMS2/SFRP1/TGFB2/SCG2/FLT1/GPC3/SFRP2/RGCC/SERPINF1 GOBP_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT -1.866424651 7.67E-08 1.08E-05 CALM2/PIK3CG/WWP2/GPER1/CXCL11/SNCA/PLCG2/NLGN3/PSEN2/TRPC1/PM20D1/RYR2/FXYD1/ATP1B1/CXCL10/SHANK3/KCNAB1/CASQ1/HRC/AHNAK/STK39/ADRA2A/ADRB2/KCNIP2/JPH2/FGF12/SLN/ATP1A2/CAV1/CALM1/OSR1/MEF2C/DMD/TSPAN13/REM1/ATP1B2/FLNA/FXYD6/PKD2/RELN/GRIN2A/SLC8A1/THY1/ACTN4/CLIC2/CXCL9/GPD1L/PLN/GRIA2/NPPA/EHD3/GRIA1/PLP1/SCN4B/FHL1/ACTN2/GSG1L/GEM/CASQ2/RAMP3/APLNR GOBP_REGULATION_OF_TRANSPORTER_ACTIVITY -1.833710939 2.50E-06 0.000187297 CALM2/WWP2/SNCA/PLCG2/NLGN3/PM20D1/RYR2/FXYD1/KCTD7/ATP1B1/SHANK3/KCNAB1/CASQ1/HRC/AHNAK/STK39/ADRA2A/ADRB2/KCNIP2/JPH2/TRPC6/FGF12/SLN/ATP1A2/CAV1/CALM1/OSR1/MEF2C/PPARG/DMD/REM1/ATP1B2/FXYD6/PKD2/RELN/GRIN2A/ACTN4/CLIC2/GPD1L/PLN/GRIA2/NPPA/EHD3/GRIA1/SCN4B/FHL1/ACTN2/GSG1L/ADIPOQ/GEM/CASQ2 GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY -1.762205478 0.000111159 0.003421728 SNAP25/MAP1B/MAP1A/SYNGR1/MME/IGSF11/KCNB1/PICK1/MAPK1/NSMF/CNTN4/CALB2/CBLN1/MCTP1/NPTN/PTN/UNC13C/SHANK3/RIMS3/ADCY1/PLK2/ZDHHC2/MEF2C/PRRT2/PPP1R9A/RELN/GRIN2A/AKAP5/EGR2/GRIA1/NTRK2/FAM107A/CX3CR1 GOBP_ENDOTHELIUM_DEVELOPMENT -1.729822877 0.00031902 0.007009424 MIR181B1/EZR/CLDN5/ROCK2/RAPGEF1/S1PR1/VCL/STARD13/F11R/NOTCH1/PROX1/ATOH8/MYADM/PDE2A/GJA4/HEY1/PTN/SCUBE1/CXCL10/BMP4/STC1/CLDN1/PLCB1/SOX17/NOTCH4/FSTL1/TMEM100/HEY2/SOX18/ACVRL1/DLL4/HEG1/ROBO4/BMP6/TIE1/COL15A1/CD34/PPP1R16B/CDH5/KDR/PECAM1 GOBP_CELL_CELL_JUNCTION_ASSEMBLY -1.705432112 0.000406384 0.008508069 CLDN5/GJD3/CDH24/MYO1C/ROCK2/VCL/PKP2/F11R/GJC1/ESAM/JUP/GJA4/WNT11/PARD6G/CLDN1/CDH8/CDH19/ACE/CD9/CAV1/FSCN1/ARVCF/PRKCH/HEG1/MPP7/CDH2/CDH5/RAMP2/PECAM1 GOBP_MUSCLE_CELL_DIFFERENTIATION -1.911415631 3.21E-09 7.38E-07 EFEMP2/MIR23A/PDLIM5/MYLK3/MYPN/AGTR2/SIX1/BCL2/ISL1/LMOD3/EHD1/MYOZ1/ALPK2/COMP/OBSL1/BVES/POPDC2/SOX9/BOC/SPEG/CD81/NOTCH1/GPER1/PROX1/SYNPO2L/OLFM2/DNER/SGCB/CSRP3/HDAC5/HEY1/BHLHE41/MYL2/FGFR2/NRAP/LMOD1/FBXO40/FHL2/CXCL10/RBM38/BMP4/TCAP/TBX5/FHOD3/TNNT2/CASQ1/LMOD2/MYEF2/CFL2/CYP26B1/BDNF/NFATC2/PDGFB/CD9/KLHL41/ZMPSTE24/EDNRB/SYNE1/RARB/EFNB2/MEF2C/SORT1/MYH6/NEBL/DMD/HEY2/RBM24/EDN1/FGF10/DMPK/MEGF10/MYH11/CAV2/FZD7/RBPMS2/MIR145/SLC8A1/AVPR1A/PGM5/CSRP1/TTN/DYSF/TMOD2/CXCL9/TMEM119/SORBS2/CDH2/IGF1/MIR100/TPM1/ACTN2/MIR140/LDB3/ACTC1/RAMP2/IGF2/PI16 GOBP_MUSCLE_STRUCTURE_DEVELOPMENT -2.015968886 1.00E-10 3.66E-08 MAP2K4/MAPK11/SRI/SIRT2/TGFBR1/TCF21/FGF9/JAM2/CAPN2/NR2F2/ASF1A/PLD3/MYL3/GTF3C5/EVC/SGCE/MEF2A/TCF15/TAZ/NMRK2/ZFPM2/EFEMP2/MIR23A/PDLIM5/MYLK3/MYPN/AGTR2/SIX1/SOX8/BCL2/MBNL3/ISL1/MTM1/S1PR1/TBX20/COPRS/LGALS1/LMOD3/EHD1/MYOZ1/SOX15/ALPK2/PKP2/CTF1/COMP/OBSL1/BVES/POPDC2/SOX9/BOC/SPEG/MYH7/CD81/ATF3/SMTN/NOTCH1/MYL6/GPER1/PROX1/LAMA5/SYNPO2L/OLFM2/ID3/MYOM2/DNER/TAGLN/WNT5A/SGCB/CSRP3/HDAC5/HEY1/BHLHE41/MYL2/RANBP3L/FZD2/UNC45B/TNNC1/FGFR2/ADARB1/NRAP/RYR2/LMOD1/FBXO40/FHL2/CXCL10/RBM38/MYLK/BMP4/MYBPC3/TCAP/TBX5/KCNAB1/FHOD3/TNNT2/CASQ1/LMOD2/MYEF2/CFL2/CRYAB/FLNB/SRPK3/TNNI3/ERBB3/CYP26B1/BDNF/JPH2/NFATC2/PDGFB/PLCB1/CD9/KLHL41/ZMPSTE24/CAV1/ASB2/EDNRB/PRICKLE1/SYNE1/FOXC1/SCX/RARB/EFNB2/MEF2C/SORT1/MYH6/NEBL/ITGA7/DMD/HEY2/RBM24/EDN1/FGF10/DMPK/MEGF10/MYH11/CAV2/FZD7/SGCD/DLL4/HBEGF/CHODL/ELN/MKX/RBPMS2/HEG1/MIR145/SLC8A1/DSP/AVPR1A/PGM5/CSRP1/TTN/MYOM1/DYSF/TMOD2/CXCL9/PDLIM7/NR1D2/TMEM119/SORBS2/CNTFR/CDH2/NKD1/EGR2/TGFB2/IGF1/FHL1/MIR100/HLF/TPM1/SGCG/ACTN2/MIR140/LDB3/ACTC1/RAMP2/IGF2/FOS/PI16/DCN/CXCL14 GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE -1.993614314 1.00E-10 3.66E-08 DGCR6/ADAMTS2/SDC3/ANG/FLRT2/TNXA/CRISPLD2/EFEMP2/IMPG2/SRPX/CHADL/LAMA4/COL4A6/PKHD1L1/COL8A2/GPC6/FBN2/LGALS1/ANGPTL5/COL4A3/SPOCK2/LRRN3/POSTN/ADAMTS6/COL5A1/FLRT3/THBS3/TIMP2/P3H2/SERAC1/COMP/LTBP4/LAMC1/AGRN/SEMA3B/CILP/FMOD/ADAMTS7/ADAMTSL5/ADAMTS5/MXRA7/VASN/ANXA11/CBLN1/FBLN5/NPNT/ALPL/ADAMTSL3/LAMA5/PXDN/L1CAM/COL16A1/SLPI/CTSG/AZGP1/PRELP/WNT5A/TRIL/ANGPTL1/S100A4/COL6A6/CASK/PTN/WNT11/FGFR2/HSPG2/FCGBP/HTRA1/COL25A1/NTN4/MMRN2/COL1A2/LRIG3/GDF10/COCH/MMP16/PRG4/ANOS1/CTSF/SMOC2/F13A1/LTBP2/PDGFB/SPARCL1/COL4A5/BCAM/TGFB1I1/VWA1/COL9A2/COLQ/POMZP3/CTSH/COL28A1/F3/TNFRSF11B/CD248/SPARC/NCAM1/ACAN/MATN2/MFAP4/KAZALD1/HAPLN1/FGF10/SPON1/RARRES2/SSC5D/PODN/LUM/ANGPT1/ITIH5/ELN/ECM2/FGL2/FBLN2/LRRN1/SOST/COL21A1/TNXB/ABI3BP/HMCN1/MMP28/GPLD1/COL12A1/LRRC17/NPPA/COL10A1/SFRP1/CDH2/VIT/COL15A1/FREM1/SBSPON/TGFB2/EGFL7/THBS4/MXRA5/FBLN1/OMD/TINAGL1/CTHRC1/MYOC/ANGPTL7/LEFTY2/OGN/OLFML2A/GPC3/MFAP5/DPT/CLEC3B/ADIPOQ/LTBP1/ITGB4/ASPN/SFRP2/CLEC14A/TIMP3/SERPINF1/DCN/MMRN1/VWF GOBP_SECOND_MESSENGER_MEDIATED_SIGNALING -1.882400418 1.22E-07 1.43E-05 ADCY2/NR5A2/MYOZ1/CAMKK2/AHR/SOX9/NPPB/RCAN3/PCLO/CALM2/MCTP1/PDE10A/CD3E/LRRK2/PLCG2/PDE2A/RASD2/RYR2/FHL2/ATP1B1/DDAH1/CASQ1/HRC/ADCY1/P2RY12/TNNI3/ERBB3/NFATC2/BST1/ATP1A2/ZMPSTE24/SELE/EDNRB/INPP5A/CALM1/DDAH2/CCL3/TMEM100/DMD/EDN1/NOS3/DMPK/PPP1R9A/NPR1/AGTR1/GRIN2A/GUCY1A2/SLC8A1/PRKAR2B/CAP2/AVPR1A/RASD1/CLIC2/PTGFR/PLN/ADGRG6/NPPA/IGF1/RCAN2/ACKR3/SELP/CX3CR1/KDR/ACKR4/CASQ2/APLNR GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY -1.782798898 6.84E-05 0.002459172 ADCY3/OXER1/GRK5/ADRB1/HTR1F/GNAI1/S1PR1/ADGRD1/GPR4/ADCY2/VIPR2/MIR30E/ADCYAP1R1/GPR176/GRIK3/GPER1/CXCL11/RGS1/ADCY9/PDE2A/ADGRL3/CXCL10/ADRA2B/ADCY5/LGR5/GNAZ/ADRA2A/ADRB2/ADCY1/ADRA1D/PTGER4/P2RY12/ADRA1B/PALM/ADCY4/EDN1/CALCRL/RAMP1/FLNA/MRAP2/AKAP5/PTGFR/CXCL9/PLN/ADGRG6/NPR3/NPY1R/RAMP3/ADGRL4/RAMP2 GOBP_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION -1.74366537 0.000520173 0.01020326 BOC/NOTCH1/GPER1/PROX1/OLFM2/HDAC5/BHLHE41/FGFR2/RBM38/BMP4/CYP26B1/BDNF/NFATC2/PDGFB/EFNB2/MEF2C/HEY2/RBM24/EDN1/DMPK/MEGF10/FZD7/RBPMS2/MIR145/TMEM119/CDH2/IGF1/MIR100/MIR140/IGF2/PI16 GOBP_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT -1.889553658 2.43E-07 2.57E-05 CALM2/PKD1/PIK3CG/GPER1/CXCL11/TMEM37/SNCA/PLCG2/CACNA2D3/PSEN2/TRPC1/NCS1/RYR2/ATP1B1/CXCL10/SMDT1/CASQ1/HRC/AHNAK/ADRA2A/P2RY12/JPH2/TRPC6/SLN/RYR3/ATP1A2/CALM1/GPM6A/CCL3/DMD/TSPAN13/REM1/PKD2/GRIN2A/SLC8A1/THY1/CLIC2/CXCL9/CCL19/GAS6/PLN/NPPA/EHD3/PLP1/SLC24A4/GEM/CASQ2/RAMP3/APLNR/CCL21 GOBP_ACTIN_FILAMENT_BUNDLE_ORGANIZATION -1.795806569 3.76E-05 0.001591243 ARHGAP28/FAM171A1/ARHGEF10/DMTN/CORO2B/INPP5K/LIMCH1/TGFBR1/SHROOM1/CGNL1/EZR/CD47/SORBS3/ROCK2/S1PR1/CCDC88A/ITGB5/FSCN2/F11R/LIMA1/SYNPO2L/SYNPO2/WNT11/ARRB1/ARHGEF10L/CALD1/DLC1/CLASP2/SHANK3/AIF1L/PTGER4/PFN2/FSCN1/ASAP3/PLS3/PPP1R9A/FLNA/ELN/FRMD7/SFRP1/ARHGEF15/TPM1/MYOC/FAM107A/RGCC GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS -1.852914026 2.10E-06 0.000165645 TNNT3/PARP2/ACE2/CTTN/ORMDL3/SRI/KCNB2/MYL3/ADA/MEF2A/DOCK4/TNNI3K/KCNJ2/ATP2B1/GSTM2/ROCK2/TRIM63/MIR17HG/PKP2/PPARGC1A/TACR1/MIR30E/CALM2/MYH7/PIK3CG/NOTCH1/MLIP/GPER1/DAPK3/LMNA/JUP/MYL2/TNNC1/RYR2/ATP1B1/ADRA2B/MYBPC3/STC1/TNNT2/CASQ1/HRC/ADRA2A/ADRB2/DSG2/TNNI3/CTNNA3/ADRA1B/SLN/MYL9/ATP1A2/CAV1/CALM1/DMD/EDN1/NOS3/CALCRL/CAMK2G/DMPK/KLF4/KCNMA1/MIR145/NR4A3/SLC8A1/DSP/CLIC2/HAND2/PLN/NPPA/EHD3/IGF1/CNN1/TPM1/CASQ2/PI16 GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY -1.937653857 9.69E-10 2.93E-07 TAS2R14/ADRB1/HTR1F/GPR146/FZD1/ADGRA3/PTGDR/GPR153/ELOVL4/AGTR2/S1PR1/P2RY10/GPR174/ADGRD1/F2RL2/GPR4/GPR20/TAS2R19/TACR1/VIPR2/GPR21/RORB/ADCYAP1R1/TAS2R31/SORCS1/GPR176/GRIK3/GPER1/FZD2/PDGFRL/ADGRL3/ADRA2B/LGR5/SUCNR1/FZD6/ADRA2A/FZD8/ADRB2/FZD4/NPY6R/ADRA1D/PTGER4/CYSLTR1/P2RY12/ADRA1B/EDNRB/LPAR4/P2RY13/ADGRA2/NPY5R/PPARG/CALCRL/FZD7/NPR1/RAMP1/AGTR1/AVPR1A/PTGFR/ADGRG6/P2RY14/GPRC5B/NPR3/MRGPRF/ACKR3/NPY1R/CX3CR1/ADGRF5/ACKR4/RAMP3/ADGRL4/APLNR/ACKR1/RAMP2 GOCC_ANCHORED_COMPONENT_OF_MEMBRANE -1.74926756 0.000254346 0.005882633 GFRA3/CNTN4/ART4/ALPL/CNTN1/GAS1/FOLR2/HYAL2/CD109/BST1/NCAM1/LSAMP/CNTN3/THY1/NEGR1/CA4/CD55/CNTFR/GPIHBP1/RGS7BP/GPC3/GFRA1/NRN1/ITLN1 GOBP_CELL_RECOGNITION -1.825498871 1.02E-05 0.000553368 IGHV3-48/EMB/IGHV3-21/IGKC/IGHV3-30/MYPN/TRDC/IGHV1-18/EXT1/IGHV3-49/CADM1/IGHG3/EPHB3/CNTN4/CD81/IGHV3-11/IGLC6/NDN/NPTN/IGHV3-33/SEMA3A/TRBC2/FOLR2/IGHG4/CNTNAP3/IGHV4-39/IGHV4-59/CD9/IGHV3-23/POMZP3/PCDH12/IGHM/IGHV3-7/MEGF10/EPHA3/IGHG1/ROBO4/CCL19/NEXN/IGHG2/IGHA1/IGHA2/PECAM1/CCL21 GOBP_HEART_MORPHOGENESIS -1.874401485 4.03E-07 3.85E-05 VANGL2/SIX1/ISL1/S1PR1/TBX20/TREX1/COL5A1/MIR17HG/EXT1/ALPK2/PKP2/INSR/SOX9/MYH7/ALDH1A2/NOTCH1/PROX1/SYNPO2L/WNT5A/PTK2/HEY1/MYL2/WNT11/FZD2/TNNC1/FGFR2/RYR2/FHL2/BMP4/DLC1/MYBPC3/TCAP/TBX5/TNNT2/TNNI3/OLFM1/RBP4/SOX17/ZMPSTE24/FOXC1/RARB/MEF2C/SLIT2/MYH6/TMEM100/NPY5R/HEY2/NOS3/EPHB4/SLIT3/SOX18/ACVRL1/DLL4/SEMA3C/FLNA/PKD2/ELN/HEG1/DSP/TTN/HAND2/ADGRG6/TGFB2/TPM1/TEK/NPY1R/SFRP2/ACTC1 GOMF_GATED_CHANNEL_ACTIVITY -1.879271328 3.20E-07 3.15E-05 KCNK7/SCN3B/ANO2/ANO10/KCNK2/SCN5A/ANXA6/TMC8/SCNN1D/TRPV1/TMC6/TRPM4/TMC7/KCNC4/KCNH2/GRID1/KCNS3/ANO1/SCN1B/CLIC6/HVCN1/KCNJ12/KCND2/KCNMB2/SCNN1B/CLIC3/NALCN/SCN2B/KCNB2/SNAP25/CACNB4/CHRNE/ANO6/KCNA5/VDAC3/KCNJ2/KCNB1/GLRB/KCNMB1/FAM155B/KCNQ4/MCOLN3/KCNK5/TMEM109/GABRA4/GRIK3/KCNA4/TMEM37/CACNA2D3/GABRB1/KCNA3/KCNMB4/CLCN4/NCS1/RYR2/KCNJ8/SCN3A/KCNAB1/KCNK6/KCNK17/ABCC9/CYBB/KCNIP2/RYR3/SCN9A/TMEM150C/ANO5/KCNN3/KCNMA1/KCNJ3/PKD2/GRIN2A/CLIC2/GRIA2/GRIA1/SCN4B/CLIC5/SCN7A GOBP_REGULATION_OF_ATPASE_ACTIVITY -1.650978075 0.004727153 0.045917703 TMEM64/TNNT3/TOR1AIP1/MYL3/RAB4A/RGN/MYL4/TPM2/MSH2/CNN3/TNNC1/ATP1B1/MYBPC3/TNNT2/TNNI3/PFN2/MYH6/IFIT1/GABARAPL2/FGF10/ATP1B2/DNAJB4/PLN/TPM1 GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS -1.69325399 0.000923716 0.014577837 NOTCH1/WNT5A/CASK/FSTL3/SEMA6A/HTRA1/TOB1/MMRN2/TWSG1/SORL1/HTRA3/SLIT2/ADGRA2/PPARG/HHEX/RBPMS2/SOST/SFRP1/CRIM1/SFRP2/DCN/CHRDL1 GOBP_STRESS_FIBER_ASSEMBLY -1.718350585 0.000794266 0.013160564 ARHGAP28/FAM171A1/ARHGEF10/CORO2B/INPP5K/LIMCH1/TGFBR1/CGNL1/CD47/SORBS3/ROCK2/S1PR1/CCDC88A/ITGB5/F11R/SYNPO2L/WNT11/ARRB1/ARHGEF10L/DLC1/CLASP2/PTGER4/PFN2/ASAP3/PPP1R9A/ELN/FRMD7/SFRP1/ARHGEF15/TPM1/MYOC/RGCC GOBP_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES -1.868456644 2.66E-06 0.000194738 CLDN5/PCDHB7/IGSF11/PTPRM/PCDHB4/EMB/CLSTN2/CDH24/MYPN/GPC6/SLITRK3/FLRT3/CADM1/PLXNB3/OBSL1/PCDH10/CNTN4/CBLN1/PKD1/SLITRK1/L1CAM/NPTN/MYADM/ESAM/PCDH11X/DSC3/LRRC4B/ADGRL3/PCDH19/AJUBA/FAT1/PCDH1/CLDN1/CDH8/PTPRD/CDH19/DSG2/SPARCL1/SELE/MYOT/SELL/SCARF2/PCDH12/ARVCF/PCDH7/KLF4/PCDH20/ROBO4/HMCN1/MPZL2/PCDH17/NEXN/CDH2/TGFB2/SELP/AMIGO2/MPZ/ADIPOQ/CDH5/PECAM1 GOMF_CHANNEL_REGULATOR_ACTIVITY -1.731127618 0.000314481 0.006934192 PRKCB/AKAP9/LYNX1/YWHAH/KCNS3/SCN1B/PACSIN3/KCNMB2/WNK2/SRI/FGF11/SCN2B/SGK1/ANKRD36C/PTPN3/BCL2/KCNMB1/PKP2/SNTA1/STX7/CALM2/KCNMB4/FXYD1/KCNAB1/ABCC9/ADRB2/KCNIP2/TNNI3/FGF12/CAV1/CALM1/TSPAN13/REM1/FLNA/FXYD6/GPD1L/GPLD1/SCN4B/GEM GOBP_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING -1.679187397 0.002365584 0.029301195 PLXNB1/ROR1/ERBB4/CAT/ROR2/INSR/SOX9/PIK3CG/GPER1/PDGFC/JAK2/PTK2/LEP/CCL5/PDGFD/ERBB3/PDGFB/ANGPT1/TGFB2/IGF1/NTRK2/FLT1/MYOC/SELP/TEK/KDR/DCN GOBP_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY -1.794880346 0.000105275 0.00330256 FBN2/TBX20/SKIL/MIR17HG/BAMBI/PMEPA1/SLC2A10/CILP/VASN/NOTCH1/CIDEA/WNT5A/FSTL3/HTRA1/TOB1/IL17RD/TWSG1/FST/CD109/SORL1/TGFB1I1/CAV1/HTRA3/PPARG/CAV2/RBPMS2/SOST/RASL11B/SFRP1/CRIM1/LTBP1/ASPN/SFRP2/CHRDL1 GOBP_REGULATION_OF_OSSIFICATION -1.728902261 0.000575681 0.010650455 GPM6B/ANO6/BMPR1B/ATP2B1/BCL2/S1PR1/FBN2/KL/MAPK1/COMP/ISG15/SOX9/NOTCH1/WNT5A/OSR2/PTN/BMP4/ADRB2/PTGER4/ZMPSTE24/OSR1/MEF2C/CCL3/PKDCC/SLC8A1/SOST/TMEM119/BMP6/SFRP1/EGR2/TGFB2/OMD/TPH1 GOBP_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY -1.732757717 0.000809295 0.013242619 ARHGAP28/ARHGEF10/CORO2B/INPP5K/LIMCH1/TGFBR1/CGNL1/CD47/SORBS3/ROCK2/S1PR1/CCDC88A/F11R/SYNPO2L/SYNPO2/WNT11/ARHGEF10L/DLC1/CLASP2/SHANK3/PTGER4/PFN2/ASAP3/PPP1R9A/FLNA/FRMD7/SFRP1/ARHGEF15/TPM1/MYOC/RGCC GOBP_ORGAN_GROWTH -1.825976256 1.79E-05 0.00091217 MAP2K4/MAPK11/NDRG4/TGFBR1/EVC/ERBB4/ZFPM2/MIR23A/PDLIM5/AGTR2/BCL2/VGLL4/S1PR1/TBX20/MAPK1/MIR17HG/EXT1/THBS3/WWC3/COMP/RARG/SOX9/NLGN4X/NOTCH1/PROX1/FGF7/LEP/AR/BNC2/FGFR2/RSPO2/STC1/TBX5/ESR1/RBP4/ZMPSTE24/FOXC1/RARB/MEF2C/MYH6/HEY2/EDN1/FGF10/HEG1/ACACB/SORBS2/TGFB2/IGF1/IGF2/PI16 GOBP_REGULATION_OF_POTASSIUM_ION_TRANSPORT -1.67006815 0.004602655 0.044998909 KCNH2/ALG10B/KIF5B/CAB39/WNK2/ANO6/KCNA5/KCNJ2/KCNMB1/WWP2/ATP1B1/KCNAB1/STK39/ADRA2A/KCNIP2/CAV1/ATP1B2/FLNA/NPPA/FHL1/ACTN2/CASQ2 GOBP_REGULATION_OF_ACTOMYOSIN_STRUCTURE_ORGANIZATION -1.732265879 0.000659648 0.011607095 ARHGAP28/ARHGEF10/CORO2B/INPP5K/LIMCH1/TGFBR1/CGNL1/CD47/SORBS3/MYLK3/ROCK2/S1PR1/CCDC88A/F11R/PROX1/SYNPO2L/WNT11/ARHGEF10L/DLC1/CLASP2/PTGER4/PFN2/ASAP3/EDN1/PPP1R9A/FRMD7/SFRP1/ARHGEF15/TPM1/MYOC/RGCC GOBP_NEURAL_CREST_CELL_DIFFERENTIATION -1.710126892 0.001353966 0.019353934 SOX8/ISL1/MAPK1/EXT1/SEMA3B/SOX9/FBXL17/SEMA3E/ALDH1A2/LAMA5/SEMA6A/BMP4/SEMA3A/SOX10/EDNRB/FOXC1/MEF2C/EDN1/SEMA3C/FRZB/HAND2/SEMA3D/SFRP1/CDH2/SEMA3G GOBP_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT -1.78688478 9.73E-05 0.003213753 ANO6/RGN/RGS9/KCNJ2/GSTM2/TMSB4X/KCNMB1/CALM2/GPER1/CXCL11/SNCA/PLCG2/NLGN3/TRPC1/RYR2/FXYD1/ATP1B1/CXCL10/SHANK3/CASQ1/ADRB2/KCNIP2/JPH2/CALM1/DMD/ATP1B2/FLNA/PKD2/RELN/THY1/ACTN4/CXCL9/NPPA/EHD3/PLP1/ACTN2/RAMP3/APLNR GOBP_CYTOSOLIC_CALCIUM_ION_TRANSPORT -1.871154136 4.92E-06 0.000312367 RGS9/ATP2B1/BCL2/GSTM2/SLC25A23/MICU3/FAM155B/MCOLN3/CALM2/GPER1/CXCL11/SNCA/PLCG2/PSEN2/TRPC1/RYR2/CXCL10/SMDT1/CASQ1/HRC/JPH2/RYR3/ATP1A2/CAV1/CALM1/CCL3/DMD/PKD2/GRIN2A/SLC8A1/THY1/CLIC2/CXCL9/CCL19/PLN/CASQ2/RAMP3/APLNR/CCL21 GOBP_CALCIUM_MEDIATED_SIGNALING -1.890786902 1.37E-06 0.00011517 NR5A2/MYOZ1/CAMKK2/RCAN3/CALM2/MCTP1/CD3E/LRRK2/PLCG2/RYR2/FHL2/ATP1B1/CASQ1/HRC/P2RY12/TNNI3/ERBB3/NFATC2/BST1/ATP1A2/ZMPSTE24/SELE/EDNRB/CALM1/CCL3/TMEM100/DMD/EDN1/DMPK/PPP1R9A/AGTR1/GRIN2A/SLC8A1/AVPR1A/CLIC2/PTGFR/PLN/IGF1/RCAN2/ACKR3/SELP/CX3CR1/KDR/ACKR4/CASQ2 GOBP_REGULATION_OF_BLOOD_CIRCULATION -1.963010745 1.58E-08 2.99E-06 SRI/SCN2B/CACNB4/MYL3/ADA/ADRB1/MEF2A/CYP2J2/KCNA5/GJD3/DOCK4/TNNI3K/PER2/KCNJ2/AGTR2/ATP2B1/GSTM2/ISL1/MYL4/PKP2/SLC4A3/SNTA1/BVES/POPDC2/MIR30E/THRA/GJC1/CALM2/MYH7/PIK3CG/JAK2/CACNA2D3/KCNMB4/LEP/JUP/CSRP3/MYL2/TRPC1/RYR2/FXYD1/ATP1B1/ADRA2B/STC1/KCNK6/TNNT2/CASQ1/HRC/SEMA3A/ABCC9/ADRA2A/ACE/KCNIP2/ADRA1D/DSG2/TNNI3/CTNNA3/ADRA1B/RYR3/ATP1A2/ZMPSTE24/CAV1/S100A1/CALM1/MYH6/DMD/HEY2/EDN1/DMPK/NPR1/KCNJ3/ATP1B2/AGTR1/HBEGF/FLNA/FXYD6/SLC8A1/DSP/AVPR1A/CLIC2/GPD1L/PLN/NPPA/EHD3/TGFB2/SCN4B/TPM1/THRB/CASQ2/DES GOBP_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT -1.776387796 0.000163033 0.004465805 CLDN5/PTPRM/VASH1/ROCK2/COL4A3/GPR4/NPPB/MIR30E/SEMA3E/PTN/HSPG2/SEMA6A/CXCL10/PLK2/FOXC1/SPARC/PPARG/KLF4/NPR1/HHEX/MIR145/TIE1/TGFB2/THBS4/TEK/ANGPTL7/KLF2/RGCC/ECSCR/SERPINF1/DCN GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS -1.772963003 0.00036951 0.007895579 RGN/ANG/CAT/CNEP1R1/DDHD2/PNPLA4/PCK1/LPIN3/CPT1A/PIK3CG/LIPE/DGKG/THRSP/PNPLA2/SORL1/CAV1/MGLL/GPAM/MTTP/GPLD1/APOB/LPL/FABP3/C3/FABP4 GOBP_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT -1.834423435 4.99E-05 0.001962122 TCF21/NR2F2/MYL3/GTF3C5/TAZ/SIX1/SOX8/BCL2/MTM1/LMOD3/MYOZ1/BVES/POPDC2/ATF3/NOTCH1/MYL6/MYOM2/DNER/CSRP3/KCNAB1/CASQ1/CFL2/CYP26B1/KLHL41/CAV1/ASB2/SCX/MEF2C/RBM24/MEGF10/CAV2/ELN/MYOM1/NR1D2/CNTFR/EGR2/HLF/IGF2/FOS/DCN GOBP_REGULATION_OF_METAL_ION_TRANSPORT -1.929549438 8.22E-08 1.08E-05 CRACR2B/CALM2/PIK3CG/GPER1/CXCL11/SNCA/PLCG2/PSEN2/CCL5/TRPC1/RYR2/FXYD1/ATP1B1/CXCL10/MYLK/STC1/CASQ1/HRC/AHNAK/ADRA2A/KCNIP2/P2RY12/IL16/JPH2/PDGFB/TRPC6/SLN/ATP1A2/CAV1/CALM1/CCL3/DMD/TSPAN13/CAMK2G/WFS1/REM1/ATP1B2/PKD2/SLC8A1/THY1/CLIC2/CXCL9/PLN/NPPA/EHD3/PLP1/GEM/CASQ2/RAMP3/APLNR GOBP_REGULATION_OF_BIOMINERALIZATION -1.71583146 0.002276858 0.028658911 GPM6B/ANO6/BMPR1B/ATP2B1/ROCK2/S1PR1/FBN2/KL/COMP/ISG15/SOX9/NOTCH1/OSR2/HEY1/PTN/BMP4/ADRB2/ZMPSTE24/OSR1/MEF2C/CCL3/PKDCC/HEY2/NOS3/SLC8A1/TMEM119/GAS6/BMP6/OMD/ASPN GOBP_REGULATION_OF_CATION_CHANNEL_ACTIVITY -1.860817548 4.00E-05 0.001656901 PLCG2/NLGN3/SHANK3/KCNAB1/CASQ1/HRC/AHNAK/ADRB2/KCNIP2/JPH2/FGF12/CAV1/CALM1/MEF2C/DMD/REM1/PKD2/RELN/GRIN2A/CLIC2/PLN/GRIA2/NPPA/EHD3/GRIA1/ACTN2/GSG1L/GEM/CASQ2 GOBP_SMOOTH_MUSCLE_CONTRACTION -1.727612703 0.001106185 0.016735427 RAP1GDS1/DOCK5/GHRL/SRF/ATP2B4/SETD3/ADRA1A/ZDHHC21/SULF2/OXTR/TACR2/ROCK1/HTR7/PROK2/PIK3C2A/NMUR1/SCNN1B/CTTN/ORMDL3/KCNB2/ADA/DOCK4/ATP2B1/ROCK2/TACR1/COMP/SMTN/GPER1/DAPK3/BBS2/MYLK/ADRA2B/ADRA2A/ADRB2/ATP1A2/CAV1/EDNRB/EDN1/CALCRL/MYH11/KCNMA1/MIR145/SLC8A1/CNN1/ACTA2 GOBP_STRIATED_MUSCLE_CELL_DIFFERENTIATION -1.953692315 1.55E-08 2.99E-06 PDLIM5/MYLK3/MYPN/AGTR2/SIX1/BCL2/ISL1/LMOD3/EHD1/MYOZ1/ALPK2/COMP/OBSL1/BVES/POPDC2/CD81/NOTCH1/PROX1/SYNPO2L/DNER/SGCB/CSRP3/HDAC5/BHLHE41/MYL2/NRAP/LMOD1/FHL2/CXCL10/RBM38/BMP4/TCAP/TBX5/FHOD3/TNNT2/CASQ1/LMOD2/MYEF2/CFL2/CYP26B1/BDNF/NFATC2/CD9/KLHL41/ZMPSTE24/RARB/EFNB2/MEF2C/SORT1/MYH6/NEBL/DMD/HEY2/RBM24/EDN1/DMPK/MYH11/CAV2/FZD7/SLC8A1/AVPR1A/PGM5/CSRP1/TTN/TMOD2/CXCL9/TMEM119/SORBS2/CDH2/IGF1/TPM1/ACTN2/LDB3/ACTC1/IGF2/PI16 GOBP_CARDIAC_MUSCLE_CELL_DIFFERENTIATION -1.779796828 0.000419885 0.008731921 MIR23A/PDLIM5/MYLK3/AGTR2/ISL1/ALPK2/OBSL1/BVES/PROX1/SGCB/CSRP3/MYL2/NRAP/FHL2/BMP4/TCAP/TBX5/FHOD3/ZMPSTE24/RARB/EFNB2/MEF2C/MYH6/NEBL/HEY2/EDN1/MYH11/FZD7/SLC8A1/TTN/SORBS2/IGF1/ACTN2/ACTC1/PI16 GOMF_ION_CHANNEL_BINDING -1.822821631 0.000173974 0.004662814 PKP2/SNTA1/TCAF1/CALM2/PKD1/BAG2/NPTN/LRRK2/ARRB1/RYR2/FXYD1/TCAP/KCNAB1/RIMS3/HRC/ABCC9/KCNIP2/FGF12/CAV1/CALM1/RIMS4/PPP1R9A/FLNA/PKD2/SLC8A1/ACTN4/GPD1L/SCN4B/FHL1/ACTN2/CDH5 GOBP_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL -1.876870535 1.90E-05 0.000958148 CALM2/GPER1/CXCL11/SNCA/PLCG2/TRPC1/RYR2/CXCL10/CASQ1/HRC/JPH2/RYR3/ATP1A2/CAV1/CALM1/CCL3/DMD/PKD2/GRIN2A/SLC8A1/THY1/CLIC2/CXCL9/CCL19/PLN/CASQ2/RAMP3/APLNR/CCL21 GOBP_VASCULOGENESIS -1.714755914 0.00193872 0.025594402 GJC1/NOTCH1/HEY1/TBX5/FZD4/TNNI3/RRAS/SOX17/CAV1/TMEM100/HEY2/ITGB8/SOX18/HEG1/RASIP1/TIE1/CD34/EGFL7/NTRK2/ACKR3/KDR/APLNR/RAMP2 GOBP_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION -1.770249186 0.000250035 0.005866862 ANKS1B/NLGN1/HSPB1/TJP1/KIF17/ACTB/LAMTOR3/KIF5B/GRIP2/ABHD17B/CLSTN1/SNAP25/MAP1A/CGNL1/GPC6/GRIP1/VCL/F11R/STX7/PCLO/NPTN/WNT5A/LGI1/ZDHHC2/FLNA/ADAM22/GRIN2A/HEG1/DSP/MPP7/CDH5/PECAM1 GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX -2.078411474 1.00E-10 3.66E-08 ADAMTS2/SDC3/ANG/TNXA/EFEMP2/IMPG2/SRPX/CHADL/LAMA4/COL4A6/COL8A2/GPC6/FBN2/LGALS1/ANGPTL5/COL4A3/POSTN/COL5A1/THBS3/TIMP2/P3H2/COMP/LTBP4/LAMC1/AGRN/SEMA3B/CILP/FMOD/ADAMTS5/MXRA7/ANXA11/CBLN1/FBLN5/NPNT/LAMA5/PXDN/L1CAM/COL16A1/SLPI/CTSG/AZGP1/PRELP/WNT5A/ANGPTL1/S100A4/COL6A6/CASK/PTN/FGFR2/HSPG2/HTRA1/COL25A1/NTN4/MMRN2/COL1A2/GDF10/COCH/PRG4/CTSF/SMOC2/F13A1/LTBP2/PDGFB/SPARCL1/COL4A5/BCAM/TGFB1I1/VWA1/COL9A2/COLQ/CTSH/COL28A1/F3/SPARC/NCAM1/ACAN/MATN2/MFAP4/KAZALD1/HAPLN1/FGF10/SPON1/RARRES2/SSC5D/PODN/LUM/ANGPT1/ITIH5/ELN/FGL2/FBLN2/SOST/COL21A1/TNXB/ABI3BP/HMCN1/MMP28/COL12A1/NPPA/COL10A1/SFRP1/CDH2/VIT/COL15A1/FREM1/SBSPON/TGFB2/EGFL7/THBS4/MXRA5/FBLN1/OMD/TINAGL1/CTHRC1/MYOC/ANGPTL7/LEFTY2/OGN/GPC3/MFAP5/DPT/CLEC3B/ADIPOQ/LTBP1/ITGB4/ASPN/SFRP2/CLEC14A/TIMP3/SERPINF1/DCN/MMRN1/VWF GOMF_POTASSIUM_CHANNEL_ACTIVITY -1.709364582 0.002594039 0.030664899 TMEM38A/KCNC4/KCNH2/KCNS3/KCNJ12/KCND2/KCNMB2/KCNB2/SNAP25/KCNA5/KCNJ2/KCNB1/KCNMB1/KCNQ4/KCNK5/GRIK3/KCNA4/KCNA3/KCNMB4/TMEM175/KCNJ8/KCNAB1/KCNK6/KCNK17/ABCC9/KCNIP2/KCNN3/KCNMA1/KCNJ3/PKD2 GOBP_SEQUESTERING_OF_CALCIUM_ION -1.835828429 0.000307917 0.006837952 CALM2/GPER1/CXCL11/SNCA/PLCG2/TRPC1/RYR2/CXCL10/CASQ1/HRC/JPH2/RYR3/ATP1A2/CALM1/CCL3/DMD/PKD2/SLC8A1/THY1/CLIC2/CXCL9/CCL19/PLN/CASQ2/APLNR/CCL21 GOBP_CARDIAC_CHAMBER_DEVELOPMENT -1.900359171 8.06E-06 0.000459635 ISL1/TBX20/ADAMTS6/MIR17HG/PKP2/ZBTB14/LMO4/MYH7/NOTCH1/PROX1/WNT5A/PDE2A/HEY1/MYL2/WNT11/FZD2/TNNC1/FGFR2/RYR2/FHL2/BMP4/MYBPC3/TBX5/TNNT2/TNNI3/RBP4/ZMPSTE24/FOXC1/RARB/MEF2C/SLIT2/MYH6/NPY5R/HEY2/SLIT3/DLL4/SEMA3C/HEG1/DSP/HAND2/ADGRG6/TGFB2/TPM1/TEK/SFRP2 GOBP_ACTION_POTENTIAL -1.840155334 5.61E-05 0.002113133 SCN1B/GNA14/KCND2/KCNMB2/SRI/SCN2B/KCNA5/PTPN3/KCNJ2/KCNB1/PKP2/SLC4A3/SNTA1/GJC1/GPER1/KCNMB4/JUP/RYR2/KCNJ8/ATP1B1/SCN3A/KCNIP2/DSG2/CTNNA3/FGF12/ATP1A2/SCN9A/CAV1/CALM1/DMD/KCNJ3/FLNA/SLC8A1/DSP/GPD1L/SCN4B/NTRK2/SCN7A GOBP_CELLULAR_EXTRAVASATION -1.701029772 0.005223842 0.04921492 SELPLG/CD99/RIPK3/ITGA1/JAM2/CD47/EXT1/F11R/PIK3CG/LEP/PDGFD/PTGER4/PLCB1/BST1/SELE/PODXL2/SELL/XG/THY1/SELP/CX3CR1/PECAM1/PLVAP/CCL21 GOBP_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE -1.854721134 0.000226094 0.005491619 CD46/IGLV3-25/IGKV1D-33/IGLV1-47/C1QA/IGHV3-48/IGLV1-40/IGKC/IGHV3-30/IGKV1-12/IGLV3-19/IGHG3/SPNS2/IGKV2-30/CD81/IGHV3-11/IGLC6/IGKV1-5/IGHV3-33/IGLV2-14/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/IGHV3-23/IGKV3-20/IGHV3-7/IGHG1/CD55/C6/IGHG2/CFI/C3/C7 GOBP_MULTICELLULAR_ORGANISMAL_SIGNALING -1.937864484 1.11E-06 9.76E-05 SCN1B/ATP1A3/KCNJ12/KCND2/KCNMB2/ACE2/ATP2A3/SRI/SCN2B/CACNB4/MEF2A/KCNA5/GJD3/TNNI3K/KCNJ2/ATP2B1/ISL1/S1PR1/PKP2/SLC4A3/GJC1/CALM2/GPER1/CACNA2D3/KCNMB4/JUP/TRPC1/RYR2/FXYD1/ATP1B1/SCN3A/KCNK6/CASQ1/HRC/ABCC9/KCNIP2/DSG2/CTNNA3/FGF12/RYR3/ATP1A2/SCN9A/ZMPSTE24/CAV1/CALM1/DMPK/NPR1/KCNJ3/ATP1B2/FLNA/FXYD6/SLC8A1/DSP/AVPR1A/PLN/NPPA/EHD3/SCN4B/NTRK2/SCN7A/CASQ2 GOCC_INTRINSIC_COMPONENT_OF_SYNAPTIC_MEMBRANE -1.834003756 0.000127008 0.003725172 PTPRA/SLC1A2/APH1A/PRRT1/LRRTM2/ATP2B4/ADRA1A/NLGN1/PTPRS/SLITRK2/GRID1/LRRC4/KCND2/ABHD17B/CLSTN1/ERBB4/CLSTN2/ATP2B1/SLITRK3/FLRT3/GABRA4/SLITRK1/NPTN/KCNA3/NLGN3/CNTN1/LRRC4B/EPHA7/PTPRD/ADCY1/GPM6A/EFNB2/KCNJ3/ADAM22/GRIN2A/SLC8A1/PCDH17/CDH2/GRIA1/RGS7BP/GSG1L GOCC_SARCOPLASM -1.738847827 0.001771294 0.024047833 GSTM2/HABP4/P3H2/POMT1/TMEM109/SRL/RYR2/CASQ1/HRC/JPH2/SLN/RYR3/KLHL41/S100A1/SLC2A4/MEF2C/CAMK2G/DMPK/CMYA5/RASD1/PLN/THBS4/CASQ2/FABP3 GOCC_CATION_CHANNEL_COMPLEX -1.929310627 4.89E-06 0.000312367 SCN3B/MICU1/NLGN1/KCNK2/SCN5A/SCNN1D/AKAP9/MICU2/TRPM4/SESTD1/KCNC4/KCNH2/KCNS3/SCN1B/KCND2/KCNMB2/MCU/SCNN1B/CTTN/SCN2B/KCNB2/SNAP25/CACNB4/KCNA5/KCNJ2/KCNB1/MICU3/KCNMB1/KCNQ4/CALM2/PKD1/GRIK3/OLFM2/KCNA4/CACNA2D3/KCNA3/KCNMB4/TRPC1/RYR2/KCNJ8/SMDT1/SCN3A/KCNAB1/KCNK6/ABCC9/KCNIP2/TRPC6/RYR3/SCN9A/CALM1/KCNMA1/KCNJ3/PKD2/GRIN2A/GRIA2/GRIA1/SCN4B/SCN7A/CASQ2 GOBP_RESPONSE_TO_CALCIUM_ION -1.901694829 1.40E-05 0.000744711 SLC25A13/MEF2A/EEF2K/SYT17/ITPKB/SLC25A23/KCNMB1/CALM2/ANXA11/SYT15/CPNE2/CCND1/WNT5A/KCNMB4/TRPC1/RASGRP2/RYR2/JUND/TNNT2/SUCNR1/ADCY1/KCNIP2/RYR3/CAV1/CALM1/MEF2C/SPARC/EDN1/DUSP1/KCNMA1/MTTP/PKD2/TTN/GPLD1/CPNE4/FOSB/CASQ2/FOS GOBP_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT -1.989335835 1.53E-07 1.73E-05 MAP2K4/MAPK11/NDRG4/TGFBR1/MYL3/MEF2A/ERBB4/TAZ/ZFPM2/MIR23A/PDLIM5/MYLK3/AGTR2/VGLL4/ISL1/S1PR1/TBX20/MAPK1/MIR17HG/ALPK2/PKP2/OBSL1/BVES/GJC1/MYH7/ALDH1A2/NOTCH1/PROX1/WNT5A/SGCB/CSRP3/MYL2/TNNC1/FGFR2/NRAP/RYR2/FHL2/BMP4/MYBPC3/TCAP/TBX5/FHOD3/TNNT2/DSG2/TNNI3/ERBB3/JPH2/RBP4/ZMPSTE24/FOXC1/RARB/EFNB2/MEF2C/MYH6/NEBL/HEY2/EDN1/MYH11/FZD7/SGCD/DLL4/HEG1/SLC8A1/DSP/TTN/SORBS2/PLN/TGFB2/IGF1/TPM1/SGCG/ACTN2/ACTC1/PI16 GOBP_HEART_GROWTH -1.788392119 0.000538451 0.010345831 MAP2K4/MAPK11/NDRG4/TGFBR1/ERBB4/ZFPM2/MIR23A/PDLIM5/AGTR2/VGLL4/S1PR1/TBX20/MAPK1/MIR17HG/NOTCH1/PROX1/FGFR2/TBX5/RBP4/FOXC1/MEF2C/MYH6/HEY2/EDN1/HEG1/ACACB/SORBS2/TGFB2/IGF1/PI16 GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY -1.852059613 0.000102487 0.003280502 S1PR1/ADGRD1/GPR4/ADCY2/GPER1/CXCL11/ADCY9/ADGRL3/CXCL10/ADRA2B/ADCY5/LGR5/ADRA2A/ADRB2/ADCY1/ADRA1D/PTGER4/ADRA1B/ADCY4/CALCRL/RAMP1/MRAP2/PTGFR/CXCL9/PLN/ADGRG6/RAMP3/ADGRL4/RAMP2 GOBP_MUSCLE_TISSUE_DEVELOPMENT -2.106530044 1.00E-10 3.66E-08 MAP2K4/MAPK11/NDRG4/SIRT2/TGFBR1/TCF21/NR2F2/MYL3/GTF3C5/MEF2A/ERBB4/TAZ/ZFPM2/EFEMP2/MIR23A/PDLIM5/MYLK3/AGTR2/SIX1/SOX8/BCL2/VGLL4/ISL1/MTM1/S1PR1/TBX20/LMOD3/MAPK1/MIR17HG/MYOZ1/SOX15/ALPK2/PKP2/PPARGC1A/OBSL1/BVES/POPDC2/SOX9/GJC1/MYH7/ATF3/ALDH1A2/NOTCH1/MYL6/PROX1/MYOM2/DNER/WNT5A/SGCB/CSRP3/MYL2/TNNC1/FGFR2/NRAP/RYR2/FHL2/MYLK/BMP4/MYBPC3/TCAP/TBX5/KCNAB1/FHOD3/TNNT2/CASQ1/CFL2/SRPK3/DSG2/TNNI3/ERBB3/CYP26B1/JPH2/RBP4/KLHL41/ZMPSTE24/CAV1/ASB2/FOXC1/SCX/OSR1/RARB/EFNB2/MEF2C/MYH6/NEBL/HEY2/RBM24/EDN1/MEGF10/MYH11/CAV2/FZD7/SGCD/DLL4/SEMA3C/PKD2/ELN/HEG1/MIR145/SLC8A1/DSP/PGM5/CSRP1/TTN/MYOM1/NR1D2/SORBS2/PLN/EGR2/TGFB2/IGF1/HLF/TPM1/SGCG/ACTN2/ACTC1/IGF2/FOS/PI16/DCN GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT -1.858625422 0.000187129 0.004868491 CALM2/GPER1/CXCL11/SNCA/PLCG2/CCL5/TRPC1/RYR2/ATP1B1/CXCL10/MYLK/STC1/CASQ1/JPH2/PDGFB/TRPC6/CAV1/CALM1/CCL3/WFS1/PKD2/THY1/CXCL9/EHD3/PLP1/RAMP3/APLNR GOBP_RESPONSE_TO_BMP -1.957643922 1.43E-06 0.000118451 ROR2/SKIL/BAMBI/EXT1/COMP/SOX9/ADAMTS7/NOTCH1/WNT5A/NEO1/FSTL3/HFE/BMP4/HTRA1/TOB1/TWSG1/FST/SORL1/SPINT2/HTRA3/SCX/FSTL1/TMEM100/PPARG/ACVRL1/RBPMS2/SOST/BMP6/SFRP1/TGFB2/CRIM1/LEFTY2/GPC3/MIR140/CDH5/SFRP2/SFRP4/CHRDL1 GOCC_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE -1.795541347 0.001027457 0.015818524 LRRC4/KCND2/TIAM1/ABHD17B/CLSTN1/ERBB4/CNKSR2/CLSTN2/RGS9/SLITRK3/LIN7B/NLGN4X/GABRA4/SLITRK1/NPTN/LRRC4B/EPHA7/ADCY1/PRRT2/ADAM22/GRIN2A/GRIA2/CDH2/GRIA1/RGS7BP/ACTN2/GSG1L GOBP_GLYCEROLIPID_CATABOLIC_PROCESS -1.660761462 0.004298751 0.042767414 DDHD2/PNPLA4/PNPLA7/PIK3CG/LIPE/PNPLA2/SORL1/MGLL/GPLD1/APOB/LPL/FABP3/FABP4 GOBP_PHAGOCYTOSIS_RECOGNITION -1.736963229 0.004086917 0.041482998 COLEC12/IGHV3-20/IGHV1-24/IGHV2-70/FCN1/IGHV3-66/IGHV4-4/C4BPB/PLA2G5/IGHV5-51/SCARB1/IGHD/IGHV3-72/IGHV3-48/IGHV3-21/IGKC/IGHV3-30/TRDC/IGHV1-18/IGHV3-49/IGHG3/IGHV3-11/IGLC6/IGHV3-33/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGHV3-23/IGHM/IGHV3-7/MEGF10/IGHG1/IGHG2/IGHA1/IGHA2 GOBP_CARDIAC_MUSCLE_CELL_CONTRACTION -1.734173183 0.003710758 0.03937456 SRI/SCN2B/KCNA5/KCNJ2/PKP2/SNTA1/GJC1/JUP/RYR2/KCNJ8/STC1/DSG2/CTNNA3/FGF12/ATP1A2/CAV1/KCNJ3/FLNA/DSP/GPD1L/PLN/SCN4B GOBP_REGULATION_OF_MUSCLE_CONTRACTION -1.95253249 3.81E-06 0.000260636 TNNT3/ACE2/CTTN/ORMDL3/SRI/KCNB2/MYL3/ADA/DOCK4/TNNI3K/KCNJ2/ATP2B1/GSTM2/PKP2/TACR1/MIR30E/CALM2/MYH7/PIK3CG/GPER1/DAPK3/JUP/MYL2/TNNC1/RYR2/ATP1B1/ADRA2B/MYBPC3/STC1/TNNT2/CASQ1/HRC/ADRA2A/ADRB2/DSG2/TNNI3/CTNNA3/ADRA1B/MYL9/ATP1A2/CAV1/CALM1/DMD/EDN1/CALCRL/DMPK/KCNMA1/MIR145/SLC8A1/DSP/CLIC2/PLN/NPPA/EHD3/CNN1/TPM1/CASQ2 GOBP_MUSCLE_SYSTEM_PROCESS -2.172576498 1.00E-10 3.66E-08 SRI/SCN2B/KCNB2/ITGA1/MYL3/ADA/CHRNE/MEF2A/TAZ/KCNA5/DOCK4/TNNI3K/MIR23A/PDLIM5/SORBS3/KCNJ2/AGTR2/KLF15/ATP2B1/GSTM2/ROCK2/TRIM63/TBX20/MYL4/LMOD3/TPM2/VCL/ITGB5/MIR17HG/MYOZ1/PKP2/PPARGC1A/TACR1/RCSD1/COMP/SNTA1/MIR30E/GJC1/CALM2/MYH7/MAP2K6/SMTN/PIK3CG/NOTCH1/MYL6/MLIP/GPER1/DAPK3/VEGFB/BBS2/MYOM2/LMNA/LEP/JUP/CSRP3/VIM/MYL2/TNNC1/RYR2/FXYD1/LMOD1/KCNJ8/ATP1B1/MYLK/CALD1/ADRA2B/MYBPC3/STC1/TCAP/TNNT2/CASQ1/HRC/SYNM/LMOD2/ADRA2A/ADRB2/CRYAB/KCNIP2/DSG2/TNNI3/CTNNA3/MYL12A/ADRA1B/MYL12B/FGF12/SLN/MYL9/ATP1A2/KLHL41/CAV1/EDNRB/MB/CALM1/MYOT/MYH6/DMD/HEY2/EDN1/ACTG2/NOS3/CALCRL/CAMK2G/MYL7/DMPK/MYH11/KLF4/KCNMA1/GATM/KCNJ3/FLNA/MIR145/NR4A3/SLC8A1/DSP/TTN/MYOM1/DYSF/TMOD2/CLIC2/SORBS2/GPD1L/HAND2/PLN/NPPA/EHD3/IGF1/SCN4B/CNN1/TPM1/MYOC/ACTN2/SMPX/SCN7A/ACTA2/CASQ2/ACTC1/DES/PI16 GOMF_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY -1.943127983 7.36E-06 0.000431909 KCNH2/KCNS3/ANO1/SCN1B/CLIC6/HVCN1/KCNJ12/KCND2/CLIC3/NALCN/SCN2B/KCNB2/SNAP25/CACNB4/ANO6/KCNA5/VDAC3/KCNJ2/KCNB1/KCNQ4/KCNK5/TMEM109/KCNA4/TMEM37/CACNA2D3/KCNA3/CLCN4/NCS1/KCNJ8/SCN3A/KCNAB1/KCNK6/KCNK17/ABCC9/CYBB/KCNIP2/SCN9A/KCNMA1/KCNJ3/PKD2/GRIN2A/CLIC2/SCN4B/CLIC5/SCN7A GOBP_SEGMENTATION -1.808690491 0.00032952 0.007189307 EPB41L5/ROR2/IRX1/ALDH1A2/NOTCH1/WNT5A/HOXA2/BMP4/TCAP/HOXD8/SEMA3A/FOXC1/OSR1/SEMA3C/SFRP1/NKD1/EGR2/MEOX1/NRARP/SFRP2 GOBP_CARDIAC_CHAMBER_MORPHOGENESIS -1.895113825 4.30E-05 0.001746888 ISL1/TBX20/MIR17HG/PKP2/MYH7/NOTCH1/PROX1/WNT5A/HEY1/MYL2/WNT11/FZD2/TNNC1/FGFR2/RYR2/FHL2/BMP4/MYBPC3/TBX5/TNNT2/TNNI3/RBP4/FOXC1/RARB/MEF2C/SLIT2/MYH6/NPY5R/HEY2/SLIT3/DLL4/SEMA3C/HEG1/DSP/HAND2/ADGRG6/TGFB2/TPM1/TEK/SFRP2 GOBP_REGULATION_OF_HEART_CONTRACTION -2.041371666 3.99E-09 8.87E-07 SRI/SCN2B/CACNB4/MYL3/ADA/ADRB1/MEF2A/CYP2J2/KCNA5/GJD3/TNNI3K/KCNJ2/AGTR2/ATP2B1/GSTM2/ISL1/MYL4/PKP2/SLC4A3/SNTA1/BVES/POPDC2/MIR30E/THRA/GJC1/CALM2/MYH7/PIK3CG/JAK2/CACNA2D3/JUP/CSRP3/MYL2/TRPC1/RYR2/FXYD1/ATP1B1/STC1/KCNK6/TNNT2/CASQ1/HRC/SEMA3A/ABCC9/KCNIP2/ADRA1D/DSG2/TNNI3/CTNNA3/ADRA1B/RYR3/ATP1A2/ZMPSTE24/CAV1/S100A1/CALM1/MYH6/DMD/HEY2/EDN1/DMPK/NPR1/KCNJ3/ATP1B2/HBEGF/FLNA/FXYD6/SLC8A1/DSP/AVPR1A/CLIC2/GPD1L/PLN/NPPA/EHD3/TGFB2/SCN4B/TPM1/THRB/CASQ2/DES GOBP_BONE_MORPHOGENESIS -1.829251585 0.000531737 0.01031746 EXT1/THBS3/FGF18/COMP/RARG/NAB1/SOX9/ALPL/OSR2/FGFR2/BMP4/STC1/MMP16/CYP26B1/ZMPSTE24/FOXC1/SCX/RARB/MEF2C/RAB23/TMEM119/BMP6/FREM1/TEK/SFRP2/SFRP4 GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION -1.831753618 0.00050537 0.010007618 NR2F2/MCC/MIR101-1/PTPRM/VASH1/AGTR2/STARD13/NOTCH1/JUP/HDAC5/CARD10/STC1/SEMA3A/MMRN2/MIR410/PFN2/MEF2C/SLIT2/PPARG/KLF4/ACVRL1/DLL4/RGCC/SERPINF1/DCN GOCC_LYSOSOMAL_LUMEN -1.868691456 0.000241033 0.00569942 MANBA/GPC5/CD1E/NAGLU/PLD3/SDC3/GPC6/CUBN/GM2A/IDUA/AGRN/HYAL1/FMOD/PRELP/IDS/HSPG2/NAAA/EPDR1/CTSF/ASAH1/CD74/FUCA1/ACAN/LUM/CTSK/APOB/OMD/OGN/GPC3/DCN GOMF_EXTRACELLULAR_MATRIX_BINDING -1.694404318 0.002431294 0.029642723 NTN4/SMOC2/SPARCL1/BCAM/CD248/SLIT2/SPARC/SSC5D/ELN/FBLN2/THSD1/ADGRG6/TINAGL1/OLFML2A/ITGA6/CLEC14A/DCN GOBP_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT -1.776518211 0.002645228 0.031034012 ERBB2/SIRT2/LAMB2/SOX8/ISL1/NAB1/GFRA3/LGI4/CLDN1/ERBB3/BDNF/SOX10/EDNRB/ADAM22/SERPINI1/HAND2/ADGRG6/EGR2/NTRK2/MYOC/ITGB4 GOBP_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY -1.70516273 0.002340187 0.029219443 OPRK1/ADCY3/OXER1/HTR1F/GNAI1/S1PR1/ADCY2/MIR30E/GPR176/GRIK3/RGS1/ADCY9/PDE2A/ADCY5/GNAZ/ADRA2A/ADCY1/P2RY12/PALM/ADCY4/EDN1/FLNA/AKAP5/NPR3/NPY1R GOCC_INTRINSIC_COMPONENT_OF_PRESYNAPTIC_MEMBRANE -1.659888054 0.005244247 0.04933242 ERBB4/ATP2B1/NPTN/KCNA3/CNTN1/PTPRD/GPM6A/EFNB2/KCNJ3/PCDH17/CDH2/RGS7BP GOBP_MUSCLE_ORGAN_DEVELOPMENT -2.135557115 1.00E-10 3.66E-08 SRI/SIRT2/TGFBR1/TCF21/NR2F2/MYL3/GTF3C5/EVC/SGCE/MEF2A/TCF15/TAZ/ZFPM2/EFEMP2/SIX1/SOX8/BCL2/ISL1/MTM1/S1PR1/TBX20/COPRS/LMOD3/MYOZ1/SOX15/PKP2/CTF1/BVES/POPDC2/SPEG/MYH7/ATF3/SMTN/NOTCH1/MYL6/PROX1/LAMA5/ID3/MYOM2/DNER/TAGLN/WNT5A/SGCB/CSRP3/MYL2/FZD2/UNC45B/TNNC1/FGFR2/ADARB1/RYR2/CXCL10/MYLK/BMP4/MYBPC3/TCAP/KCNAB1/TNNT2/CASQ1/CFL2/CRYAB/FLNB/SRPK3/TNNI3/ERBB3/CYP26B1/JPH2/KLHL41/CAV1/ASB2/FOXC1/SCX/MEF2C/MYH6/ITGA7/DMD/HEY2/RBM24/MEGF10/CAV2/SGCD/DLL4/HBEGF/CHODL/ELN/MKX/HEG1/MIR145/DSP/TTN/MYOM1/NR1D2/CNTFR/EGR2/TGFB2/IGF1/FHL1/HLF/TPM1/SGCG/ACTC1/IGF2/FOS/DCN GOBP_REGULATION_OF_COMPLEMENT_ACTIVATION -1.898132051 9.93E-05 0.003232742 CD46/IGLV3-25/IGKV1D-33/IGLV1-47/C1QA/IGHV3-48/IGLV1-40/IGKC/IGHV3-30/IGKV1-12/IGLV3-19/IGHG3/IGKV2-30/CD81/IGHV3-11/IGLC6/IGKV1-5/IGHV3-33/IGLV2-14/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/IGHV3-23/IGKV3-20/IGHV3-7/IGHG1/CD55/C6/IGHG2/CFI/C3/C7 GOBP_LONG_TERM_SYNAPTIC_POTENTIATION -1.812144901 0.000752823 0.012575453 SNAP25/MME/IGSF11/MAPK1/CALB2/NPTN/PTN/SHANK3/ADCY1/PLK2/ZDHHC2/PPP1R9A/RELN/GRIN2A/AKAP5/NTRK2/FAM107A/CX3CR1 GOBP_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT -2.03527399 5.96E-08 9.03E-06 MEF2A/ANO6/RGN/COX17/RGS9/KCNJ2/KLF15/GSTM2/TMSB4X/C2CD5/KCNMB1/INSR/TCAF1/CALM2/GPER1/CXCL11/SNCA/PLCG2/NLGN3/ACSL5/TRPC1/RYR2/FXYD1/ATP1B1/CXCL10/SHANK3/CASQ1/STK39/ADRB2/KCNIP2/JPH2/TRPC6/CALM1/DMD/ATP1B2/FLNA/PKD2/RELN/NR4A3/THY1/ACTN4/CXCL9/NPPA/EHD3/IGF1/PLP1/ACTN2/GPC3/ADIPOQ/RAMP3/APLNR/ITLN1/C3 GOMF_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY -1.685014524 0.002619108 0.030843967 KCNC4/KCNH2/KCNS3/KCNJ12/KCND2/KCNB2/SNAP25/KCNA5/KCNJ2/KCNB1/KCNQ4/KCNA4/KCNA3/KCNJ8/KCNAB1/KCNK6/ABCC9/KCNIP2/KCNMA1/KCNJ3/PKD2 GOBP_CARDIOCYTE_DIFFERENTIATION -1.989238255 9.25E-06 0.000504417 MIR23A/PDLIM5/MYLK3/AGTR2/ISL1/MAPK1/ALPK2/OBSL1/BVES/NOTCH1/GPER1/PROX1/SGCB/CSRP3/MYL2/NRAP/FHL2/BMP4/TCAP/TBX5/FHOD3/SOX17/ZMPSTE24/PRICKLE1/RARB/EFNB2/MEF2C/MYH6/NEBL/HEY2/EDN1/MYH11/SOX18/FZD7/SEMA3C/MIR145/SLC8A1/TTN/SORBS2/HAND2/TGFB2/IGF1/ACTN2/ACTC1/PI16 GOBP_AMINOGLYCAN_CATABOLIC_PROCESS -1.724260576 0.002762139 0.031983201 IDUA/AGRN/HYAL1/FMOD/STAB2/PRELP/IDS/HSPG2/HYAL2/FUCA1/ACAN/LUM/OMD/OGN/GPC3/DCN GOBP_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES -1.956060138 7.71E-06 0.000447759 PCDHB7/IGSF11/PTPRM/PCDHB4/EMB/CLSTN2/CDH24/MYPN/CADM1/PLXNB3/OBSL1/PCDH10/CNTN4/PKD1/L1CAM/NPTN/ESAM/PCDH11X/DSC3/PCDH19/FAT1/PCDH1/CDH8/CDH19/DSG2/MYOT/PCDH12/PCDH7/PCDH20/ROBO4/HMCN1/MPZL2/PCDH17/NEXN/CDH2/AMIGO2/CDH5/PECAM1 GOBP_CARDIAC_CONDUCTION -1.99351421 2.21E-06 0.000170833 SCN1B/ATP1A3/KCNJ12/KCND2/ACE2/ATP2A3/SRI/SCN2B/CACNB4/MEF2A/KCNA5/GJD3/TNNI3K/KCNJ2/ATP2B1/ISL1/PKP2/SLC4A3/GJC1/CALM2/CACNA2D3/JUP/TRPC1/RYR2/FXYD1/ATP1B1/KCNK6/CASQ1/HRC/ABCC9/KCNIP2/DSG2/CTNNA3/RYR3/ATP1A2/ZMPSTE24/CAV1/CALM1/DMPK/NPR1/KCNJ3/ATP1B2/FLNA/FXYD6/SLC8A1/DSP/PLN/NPPA/EHD3/SCN4B/CASQ2 GOBP_CARDIAC_VENTRICLE_DEVELOPMENT -1.939194022 8.78E-06 0.000492052 ISL1/TBX20/MIR17HG/PKP2/LMO4/MYH7/NOTCH1/PROX1/WNT5A/PDE2A/HEY1/MYL2/WNT11/FZD2/TNNC1/FGFR2/RYR2/BMP4/MYBPC3/TBX5/TNNT2/TNNI3/ZMPSTE24/FOXC1/MEF2C/SLIT2/MYH6/NPY5R/HEY2/SLIT3/DLL4/SEMA3C/HEG1/DSP/HAND2/TGFB2/TPM1/SFRP2 GOBP_EXTRACELLULAR_MATRIX_ASSEMBLY -1.666846243 0.005223842 0.04921492 LAMB2/GPM6B/EFEMP2/HAS1/SOX9/FBLN5/NOTCH1/PXDN/CLASP2/NTN4/COL1A2/MFAP4/MYH11/TNXB/GAS6/TIE1/RGCC/RAMP2 GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION -1.825554261 0.000730376 0.012374592 TNNI3K/KCNJ2/GSTM2/PKP2/MIR30E/CALM2/PIK3CG/JUP/RYR2/ATP1B1/STC1/HRC/DSG2/TNNI3/CTNNA3/ADRA1B/ATP1A2/CAV1/CALM1/DMD/SLC8A1/DSP/CLIC2/PLN/NPPA/EHD3/CASQ2 GOBP_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING -1.824103201 0.00044811 0.009165614 EPHA5/GNAI1/RNF157/ADCY2/AHR/SOX9/NPPB/PCLO/PDE10A/PDE2A/RASD2/ADCY1/EDNRB/NPR1/PRKAR2B/CAP2/ADGRG6/NPPA/APLNR GOBP_HEART_PROCESS -2.156883516 1.00E-10 3.66E-08 SRI/SCN2B/CACNB4/MYL3/ADA/ADRB1/MEF2A/CYP2J2/TAZ/KCNA5/GJD3/TNNI3K/KCNJ2/AGTR2/ATP2B1/GSTM2/ISL1/MYL4/TREX1/EXT1/PKP2/SLC4A3/SNTA1/BVES/POPDC2/MIR30E/THRA/GJC1/CALM2/MYH7/MAP2K6/PIK3CG/VEGFB/JAK2/CACNA2D3/JUP/CSRP3/MYL2/TRPC1/TNNC1/RYR2/FXYD1/KCNJ8/ATP1B1/MYBPC3/STC1/TCAP/KCNK6/TNNT2/CASQ1/HRC/SEMA3A/ABCC9/ACE/KCNIP2/ADRA1D/DSG2/TNNI3/CTNNA3/ADRA1B/FGF12/RYR3/ATP1A2/ZMPSTE24/CAV1/S100A1/CALM1/MYH6/DMD/HEY2/EDN1/DMPK/SGCD/NPR1/KCNJ3/ATP1B2/HBEGF/FLNA/FXYD6/SLC8A1/DSP/AVPR1A/TTN/CLIC2/GPD1L/PLN/NPPA/EHD3/TGFB2/SCN4B/TPM1/SGCG/THRB/CASQ2/RAMP3/ACTC1/DES GOMF_ANTIGEN_BINDING -2.015681042 7.08E-07 6.67E-05 HLA-DPB1/IGLV3-25/IGKV1D-33/CD1E/IGHV3-72/IGLV1-47/TRAV19/IGHV3-48/HLA-B/IGHV3-21/IGLV1-40/IGKC/IGHV3-30/TRDC/IGHV1-18/IGLV3-19/IGHV3-49/IGHG3/IGKV2-30/IGHV3-11/IGLC6/IGKV1-5/IGHV3-33/IGLV2-14/TRBC2/IGHG4/IGHV4-39/HLA-DQA1/IGHV4-59/IGLV2-23/HLA-DQB1/IGHV3-23/IGKV3-20/CD1C/MFAP4/IGHM/IGHV3-7/HLA-DRA/HLA-DPA1/IGHG1/HLA-DRB1/IGHG2/IGHA1/IGHA2/JCHAIN GOBP_MUSCLE_CELL_DEVELOPMENT -2.057422645 3.51E-08 5.75E-06 EFEMP2/MIR23A/PDLIM5/MYLK3/MYPN/AGTR2/SIX1/BCL2/ISL1/LMOD3/MYOZ1/ALPK2/COMP/OBSL1/BVES/NOTCH1/PROX1/SYNPO2L/DNER/SGCB/CSRP3/MYL2/NRAP/LMOD1/FHL2/BMP4/TCAP/FHOD3/TNNT2/CASQ1/LMOD2/CFL2/NFATC2/KLHL41/ZMPSTE24/MYH6/NEBL/DMD/HEY2/EDN1/MEGF10/MYH11/CAV2/SLC8A1/PGM5/CSRP1/TTN/DYSF/TMOD2/SORBS2/IGF1/TPM1/ACTN2/LDB3/ACTC1/RAMP2/PI16 GOCC_GOLGI_LUMEN -1.798863547 0.00084122 0.013682508 GOLIM4/AGRN/FMOD/F10/PRELP/WNT5A/RAB33B/HSPG2/MMP16/PDGFB/PODXL2/ACAN/LUM/GAS6/OMD/OGN/GPC3/DCN GOBP_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION -1.894650056 0.000229579 0.005511678 TNNI3K/KCNJ2/GSTM2/PKP2/MIR30E/CALM2/MYH7/PIK3CG/JUP/MYL2/RYR2/ATP1B1/MYBPC3/STC1/CASQ1/HRC/DSG2/TNNI3/CTNNA3/ADRA1B/ATP1A2/CAV1/CALM1/DMD/DMPK/SLC8A1/DSP/CLIC2/PLN/NPPA/EHD3/CASQ2 GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT -1.720996157 0.004372232 0.043221844 BCL2/GSTM2/CALM2/STC1/ADRA2A/SLN/ATP1A2/CALM1/REM1/PKD2/CLIC2/PLN/GEM/CASQ2 GOBP_TRIGLYCERIDE_METABOLIC_PROCESS -1.897872809 0.000219565 0.005362826 RGN/CAT/CNEP1R1/DDHD2/PNPLA4/PCK1/LPIN3/CPT1A/PIK3CG/LIPE/THRSP/PNPLA2/SORL1/CAV1/MGLL/GPAM/MTTP/GPLD1/APOB/LPL/FABP3/C3/FABP4 GOBP_SOMITOGENESIS -1.72104271 0.002884974 0.032854884 TCF15/EPB41L5/ROR2/ALDH1A2/NOTCH1/WNT5A/TCAP/FOXC1/SEMA3C/SFRP1/NKD1/MEOX1/NRARP/SFRP2 GOMF_LIGAND_ACTIVATED_TRANSCRIPTION_FACTOR_ACTIVITY -1.731937772 0.00422527 0.042171313 NR2F1/NR2F2/NR3C1/NR5A2/AHR/RARG/THRA/RORB/NR3C2/RXRG/AR/ESR1/RARB/PPARG/NR4A3/NR1D2/PGR/NR4A2/NR4A1/THRB GOBP_CELL_FATE_SPECIFICATION -1.764436545 0.001027772 0.015818524 SIX1/ISL1/TBX20/LMO4/SOX9/NOTCH1/WNT5A/AR/WNT11/TBX5/SOX17/SOX18/FZD7/SFRP2 GOCC_INTRINSIC_COMPONENT_OF_POSTSYNAPTIC_MEMBRANE -1.885770537 0.000255324 0.005882633 PTPRS/SLITRK2/GRID1/LRRC4/KCND2/ABHD17B/CLSTN1/ERBB4/CLSTN2/SLITRK3/FLRT3/GABRA4/SLITRK1/NPTN/KCNA3/NLGN3/CNTN1/LRRC4B/EPHA7/ADCY1/ADAM22/GRIN2A/SLC8A1/PCDH17/CDH2/GRIA1/RGS7BP/GSG1L GOBP_ACTOMYOSIN_STRUCTURE_ORGANIZATION -2.135134493 1.82E-09 4.92E-07 SORBS3/MYLK3/MYPN/ROCK2/EPB41L5/S1PR1/LMOD3/CCDC88A/ITGB5/MYOZ1/OBSL1/F11R/EPB41L4B/CNN3/PROX1/SYNPO2L/ALKBH4/FRMD3/CSRP3/MYL2/WNT11/ARRB1/NRAP/ARHGEF10L/LMOD1/DLC1/EPB41L2/CLASP2/TCAP/FHOD3/TNNT2/CASQ1/LMOD2/CFL2/PTGER4/PFN2/KLHL41/ASAP3/MYH6/NEBL/CNN2/EDN1/MYH11/PPP1R9A/ELN/PGM5/CSRP1/TTN/TMOD2/FRMD7/SFRP1/ARHGEF15/CNN1/TPM1/MYOC/ACTN2/LDB3/MYH10/RGCC/ACTC1 GOBP_MUSCLE_CONTRACTION -2.246630318 1.00E-10 3.66E-08 SRI/SCN2B/KCNB2/ITGA1/MYL3/ADA/CHRNE/TAZ/KCNA5/DOCK4/TNNI3K/SORBS3/KCNJ2/ATP2B1/GSTM2/ROCK2/TRIM63/TBX20/MYL4/LMOD3/TPM2/VCL/ITGB5/PKP2/TACR1/RCSD1/COMP/SNTA1/MIR30E/GJC1/CALM2/MYH7/MAP2K6/SMTN/PIK3CG/MYL6/GPER1/DAPK3/VEGFB/BBS2/MYOM2/JUP/CSRP3/VIM/MYL2/TNNC1/RYR2/FXYD1/LMOD1/KCNJ8/ATP1B1/MYLK/CALD1/ADRA2B/MYBPC3/STC1/TCAP/TNNT2/CASQ1/HRC/SYNM/LMOD2/ADRA2A/ADRB2/CRYAB/KCNIP2/DSG2/TNNI3/CTNNA3/MYL12A/ADRA1B/MYL12B/FGF12/MYL9/ATP1A2/KLHL41/CAV1/EDNRB/MB/CALM1/MYOT/MYH6/DMD/EDN1/ACTG2/CALCRL/MYL7/DMPK/MYH11/KCNMA1/KCNJ3/FLNA/MIR145/SLC8A1/DSP/TTN/MYOM1/DYSF/TMOD2/CLIC2/GPD1L/PLN/NPPA/EHD3/SCN4B/CNN1/TPM1/ACTN2/SMPX/SCN7A/ACTA2/CASQ2/ACTC1/DES GOBP_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT -1.743972178 0.003407652 0.0371082 LAMB2/TCF21/KLF15/CD24/GPR4/EXT1/NOTCH1/BMP4/PDGFB/OSR1/MEF2C/CD34/PROM1/ADIPOQ/ACTA2/PODXL GOCC_COLLAGEN_TRIMER -1.911571416 9.33E-05 0.003118274 COL16A1/COL6A6/COL25A1/COL1A2/COL4A5/COL9A2/COLQ/COL28A1/C1QTNF3/C1QTNF9/LUM/COL21A1/COL12A1/C1QL3/COL10A1/C1QTNF2/COL15A1/CTHRC1/ADIPOQ/C1QTNF7/DCN GOMF_PEPTIDE_RECEPTOR_ACTIVITY -1.976509163 2.38E-05 0.001124089 F2RL2/TACR1/VIPR2/ADCYAP1R1/SORCS1/LGR5/NPY6R/CYSLTR1/EDNRB/NPY5R/CALCRL/NPR1/RAMP1/AGTR1/AVPR1A/NPR3/ACKR3/NPY1R/CX3CR1/ACKR4/RAMP3/APLNR/RAMP2 GOBP_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS -1.692737671 0.004823034 0.046567745 RGN/ANG/CNEP1R1/PCK1/LPIN3/THRSP/PNPLA2/GPAM/GPLD1/LPL/C3 GOCC_CLATHRIN_COATED_ENDOCYTIC_VESICLE -1.75111466 0.001251019 0.018477038 CD207/TYRP1/ROR2/HLA-DQB2/WNT5A/FZD2/FZD4/HLA-DQA1/HLA-DQB1/CD9/CD74/HLA-DRA/HLA-DPA1/HBEGF/HLA-DRB1/HLA-DQA2/APOB GOBP_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY -1.863284303 0.000743914 0.01249681 CALM2/WWP2/SNCA/KCNAB1/STK39/ADRA2A/FGF12/SLN/ATP1A2/CAV1/CALM1/OSR1/REM1/PKD2/CLIC2/PLN/ACTN2/GEM/CASQ2 GOBP_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS -1.678587961 0.005336181 0.049787883 EPM2AIP1/DYRK2/RGN/MIR103A1/PPP1R3E/PPARGC1A/INSR/PPP1R3G/KAT2B/GPLD1/IGF1/IGF2 GOBP_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN -2.058907123 2.73E-07 2.83E-05 IGLV3-25/IGKV1D-33/IGHV3-72/IGLV1-47/C1QA/IGHV3-48/IGHV3-21/IGLV1-40/IGKC/IGHV3-30/IGKV1-12/TRDC/IGHV1-18/IGLV3-19/IGHV3-49/IGHG3/IGKV2-30/CD81/IGHV3-11/IGLC6/IGKV1-5/IGHV3-33/IGLV2-14/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/HLA-DQB1/IGHV3-23/IGKV3-20/IGHM/IGHV3-7/IGHG1/HLA-DRB1/CD55/C6/IGHG2/IGHA1/IGHA2/CFI/C3/C7 GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY -1.905319383 0.000196523 0.004967388 ERBB2/TGFBR1/ERBB4/BMPR1B/EPHA5/ROR2/INSR/ACVR1C/LTBP4/EPHB3/FLT4/FGFR2/PDGFRL/EPHA7/ERBB3/EPHB4/ACVRL1/EPHA3/TIE1/CRIM1/NTRK2/FLT1/TEK/LTBP1/KDR GOBP_ENDOCHONDRAL_BONE_MORPHOGENESIS -1.756660216 0.003272179 0.036011348 EXT1/THBS3/FGF18/COMP/RARG/NAB1/SOX9/ALPL/BMP4/STC1/MMP16/ZMPSTE24/FOXC1/SCX/RARB/MEF2C/TMEM119/BMP6/TEK GOBP_COMPLEMENT_ACTIVATION -2.074144133 1.26E-07 1.45E-05 IGHV3-48/IGHV3-21/IGLV1-40/IGKC/IGHV3-30/IGKV1-12/TRDC/IGHV1-18/IGLV3-19/IGHV3-49/IGHG3/IGKV2-30/CD81/IGHV3-11/IGLC6/IGKV1-5/IGHV3-33/IGLV2-14/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/IGHV3-23/IGKV3-20/MFAP4/IGHM/IGHV3-7/IGHG1/MASP1/CD55/C6/IGHG2/IGHA1/IGHA2/RGCC/CFI/C3/C7/CFD GOBP_CARDIAC_VENTRICLE_MORPHOGENESIS -1.86780557 0.000572407 0.010650455 TGFBR1/MYL3/ZFPM2/ISL1/TBX20/MIR17HG/PKP2/MYH7/NOTCH1/PROX1/HEY1/MYL2/TNNC1/FGFR2/RYR2/MYBPC3/TBX5/TNNT2/TNNI3/FOXC1/MEF2C/MYH6/NPY5R/HEY2/DLL4/SEMA3C/HEG1/DSP/HAND2/TGFB2/TPM1/SFRP2 GOBP_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY -1.774323226 0.002614095 0.030843347 WWP2/ATP1B1/KCNAB1/STK39/KCNIP2/CAV1/ATP1B2/NPPA/FHL1/ACTN2/CASQ2 GOCC_INTERCALATED_DISC -1.774876699 0.002109515 0.027290008 KCNA5/KCNJ2/VCL/PKP2/OBSL1/GJC1/JUP/NRAP/FXYD1/ATP1B1/DSG2/CTNNA3/ATP1A2/SLC8A1/DSP/PGM5/CDH2/SCN4B/DES GOBP_MUSCLE_ORGAN_MORPHOGENESIS -1.887583435 0.000556825 0.010519472 TGFBR1/MYL3/TCF15/ZFPM2/EFEMP2/ISL1/S1PR1/TBX20/PKP2/MYH7/NOTCH1/PROX1/WNT5A/MYL2/FZD2/TNNC1/FGFR2/ADARB1/RYR2/MYLK/MYBPC3/TCAP/TNNT2/TNNI3/FOXC1/MYH6/HEY2/DLL4/HEG1/MIR145/DSP/TTN/TGFB2/TPM1/ACTC1 GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS -1.995438773 2.31E-05 0.001115198 MYLK3/MYPN/LMOD3/MYOZ1/OBSL1/PROX1/SYNPO2L/CSRP3/MYL2/NRAP/LMOD1/CLASP2/TCAP/FHOD3/TNNT2/CASQ1/LMOD2/CFL2/CD9/KLHL41/MYH6/NEBL/EDN1/MYH11/PGM5/CSRP1/TTN/TMOD2/TPM1/ACTN2/LDB3/ITGB4/ACTC1 GOBP_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS -1.780690113 0.002321614 0.029090541 CAPN2/ADRB1/IDO1/BCL2/EXT1/TACR1/USP46/GJA4/ADRA2A/ATP1A2/VWA1/SCN9A/EDNRB/DPP4/MEF2C/RELN/THBS4/NR4A2 GOBP_CARDIAC_CELL_DEVELOPMENT -1.938682997 0.000129206 0.003771854 MEF2A/MIR23A/PDLIM5/MYLK3/AGTR2/ISL1/ALPK2/OBSL1/BVES/NOTCH1/PROX1/SGCB/CSRP3/MYL2/NRAP/FHL2/BMP4/TCAP/FHOD3/ZMPSTE24/MYH6/NEBL/HEY2/EDN1/MYH11/SLC8A1/TTN/SORBS2/IGF1/ACTN2/ACTC1/PI16 GOBP_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY -1.924584959 0.000120198 0.003576038 CALM2/PLCG2/RYR2/ATP1B1/CASQ1/HRC/AHNAK/ADRA2A/JPH2/SLN/ATP1A2/CALM1/DMD/REM1/PKD2/CLIC2/PLN/NPPA/EHD3/GEM/CASQ2 GOBP_B_CELL_RECEPTOR_SIGNALING_PATHWAY -2.04202014 9.99E-07 8.90E-05 IGHV3-20/IGHV1-24/LPXN/IGHV2-70/LCK/IGHV3-66/PLEKHA1/IGHV4-4/PRKCB/STAP1/IGHV5-51/SYK/IGHD/ITK/IGHV3-72/IGHV3-48/IGHV3-21/IGKC/IGHV3-30/BCL2/TRDC/BMX/IGHV1-18/MAPK1/IGHV3-49/IGHG3/CD81/IGHV3-11/IGLC6/SLC39A10/MNDA/CD79B/PLCG2/IGHV3-33/TRBC2/IGHG4/IGHV4-39/IGHV4-59/NFATC2/IGHV3-23/MEF2C/IGHM/IGHV3-7/PRKCH/RFTN1/IGHG1/IGHG2/IGHA1/IGHA2 GOBP_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL -1.978579673 2.18E-05 0.001073643 CALM2/GPER1/CXCL11/SNCA/TRPC1/RYR2/CXCL10/CASQ1/HRC/JPH2/ATP1A2/CAV1/CALM1/DMD/PKD2/SLC8A1/THY1/CLIC2/CXCL9/PLN/CASQ2/RAMP3/APLNR GOBP_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT -2.130064173 4.67E-08 7.45E-06 CALM2/PIK3CG/GPER1/CXCL11/SNCA/PLCG2/PSEN2/TRPC1/RYR2/ATP1B1/CXCL10/CASQ1/HRC/AHNAK/ADRA2A/JPH2/SLN/ATP1A2/CALM1/DMD/TSPAN13/REM1/PKD2/SLC8A1/THY1/CLIC2/CXCL9/PLN/NPPA/EHD3/PLP1/GEM/CASQ2/RAMP3/APLNR GOBP_NEURON_RECOGNITION -1.75087445 0.002259543 0.028556586 SEMA5A/TNN/EMB/MYPN/EXT1/EPHB3/CNTN4/NDN/NPTN/SEMA3A/PCDH12/EPHA3/ROBO4/NEXN GOMF_HORMONE_BINDING -1.843443906 0.00043802 0.009018564 INSR/VIPR2/THRA/ADCYAP1R1/GPER1/AR/SLC40A1/ALDH1A3/ATP1A2/EDNRB/CTSH/CALCRL/NPR1/RAMP1/AVPR1A/NPR3/THRB/ALDH1A1/RAMP2 GOBP_STRIATED_MUSCLE_CELL_DEVELOPMENT -2.033016925 6.85E-06 0.000409822 MYLK3/MYPN/SIX1/BCL2/LMOD3/MYOZ1/COMP/OBSL1/PROX1/SYNPO2L/DNER/SGCB/CSRP3/MYL2/NRAP/LMOD1/BMP4/TCAP/FHOD3/TNNT2/CASQ1/LMOD2/CFL2/KLHL41/ZMPSTE24/MYH6/NEBL/DMD/EDN1/MYH11/CAV2/PGM5/CSRP1/TTN/TMOD2/TPM1/ACTN2/LDB3/ACTC1 GOBP_STRIATED_MUSCLE_CONTRACTION -2.179105096 1.64E-09 4.62E-07 TAZ/KCNA5/TNNI3K/KCNJ2/GSTM2/MYL4/LMOD3/PKP2/RCSD1/SNTA1/MIR30E/GJC1/CALM2/MYH7/MAP2K6/PIK3CG/VEGFB/JUP/CSRP3/MYL2/TNNC1/RYR2/KCNJ8/ATP1B1/MYBPC3/STC1/TCAP/TNNT2/CASQ1/HRC/SYNM/DSG2/TNNI3/CTNNA3/ADRA1B/FGF12/ATP1A2/KLHL41/CAV1/MB/CALM1/MYH6/DMD/DMPK/KCNJ3/FLNA/SLC8A1/DSP/TTN/CLIC2/GPD1L/PLN/NPPA/EHD3/SCN4B/TPM1/SMPX/CASQ2/ACTC1 GOBP_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL_INVOLVED_IN_CONTRACTION -1.805171383 0.002996649 0.033816989 SCN3B/SCN5A/TRPM4/KCNH2/SCN1B/SCN2B/KCNA5/KCNJ2/PKP2/SNTA1/GJC1/JUP/RYR2/KCNJ8/DSG2/CTNNA3/FGF12/CAV1/KCNJ3/FLNA/DSP/GPD1L/SCN4B GOBP_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY -1.730307476 0.003810381 0.039797902 CALM2/KCNAB1/FGF12/CAV1/CALM1/REM1/PKD2/CLIC2/GEM/CASQ2 GOCC_POSTSYNAPTIC_DENSITY_MEMBRANE -1.921240967 0.000193734 0.004962257 LRRC4/TIAM1/ABHD17B/CLSTN1/ERBB4/CNKSR2/CLSTN2/RGS9/SLITRK3/LIN7B/NLGN4X/SLITRK1/NPTN/LRRC4B/EPHA7/ADCY1/PRRT2/ADAM22/GRIN2A/GRIA2/GRIA1/RGS7BP/ACTN2/GSG1L GOCC_MYELIN_SHEATH -1.736042355 0.003525851 0.037996082 SRD5A1/ERBB2/SIRT2/BCL2/TUBA1A/MYO1D/CALM1/PMP2/TSPAN2/PLP1/MPZ GOBP_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL -1.96482207 9.77E-05 0.003213753 CALM2/GPER1/CXCL11/SNCA/TRPC1/RYR2/CXCL10/CASQ1/HRC/JPH2/ATP1A2/CALM1/DMD/PKD2/SLC8A1/THY1/CLIC2/CXCL9/PLN/CASQ2/APLNR GOCC_INTRINSIC_COMPONENT_OF_POSTSYNAPTIC_SPECIALIZATION_MEMBRANE -1.843586784 0.000807855 0.013242619 PTPRS/GRID1/LRRC4/KCND2/ABHD17B/CLSTN1/ERBB4/CLSTN2/SLITRK3/GABRA4/SLITRK1/NPTN/LRRC4B/EPHA7/ADCY1/ADAM22/GRIN2A/CDH2/GRIA1/RGS7BP/GSG1L GOBP_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT -1.790743485 0.001472809 0.020719295 KLF15/CD24/GPR4/EXT1/NOTCH1/BMP4/PDGFB/OSR1/MEF2C/CD34/PROM1/ADIPOQ/ACTA2/PODXL GOBP_SULFUR_COMPOUND_CATABOLIC_PROCESS -1.850327995 0.000727517 0.012359838 IDUA/HYAL1/FMOD/PRELP/CSAD/IDS/ACAT1/ACAN/LUM/OMD/OGN/DCN GOBP_REGULATION_OF_HEART_RATE -2.062232841 4.06E-06 0.000266004 SRI/SCN2B/ADA/ADRB1/KCNA5/TNNI3K/KCNJ2/AGTR2/ISL1/PKP2/SNTA1/BVES/POPDC2/CALM2/MYH7/JUP/RYR2/HRC/SEMA3A/ADRA1D/DSG2/CTNNA3/ADRA1B/CAV1/CALM1/MYH6/DMD/HEY2/EDN1/KCNJ3/SLC8A1/DSP/AVPR1A/GPD1L/PLN/NPPA/SCN4B/TPM1/CASQ2 GOBP_ACTIN_FILAMENT_BASED_MOVEMENT -2.213875067 2.04E-09 5.21E-07 MYO1C/KCNJ2/CCDC88C/EPB41L5/MYL4/TPM2/WIPF3/PKP2/SNTA1/GJC1/MYH7/MYL6/JUP/VIM/MYL2/TNNC1/RYR2/KCNJ8/MYBPC3/STC1/TCAP/TNNT2/MYO1D/EPDR1/DSG2/TNNI3/CTNNA3/FGF12/ATP1A2/CAV1/MYO5B/MYH6/DMD/KCNJ3/FLNA/DSP/ACTN4/TTN/MYO5C/GPD1L/PLN/SCN4B/TPM1/ACTN2/MYH10/ACTC1/DES GOCC_SARCOPLASMIC_RETICULUM_MEMBRANE -1.753499332 0.003303212 0.036288648 TMEM109/SRL/RYR2/CASQ1/HRC/JPH2/SLN/RYR3/KLHL41/CAMK2G/DMPK/PLN/CASQ2 GOBP_POSITIVE_REGULATION_OF_OSSIFICATION -1.825968419 0.000616778 0.011052242 GPM6B/ANO6/BMPR1B/ATP2B1/FBN2/KL/ISG15/WNT5A/OSR2/PTN/BMP4/ADRB2/OSR1/MEF2C/PKDCC/SLC8A1/TMEM119/BMP6/TGFB2 GOBP_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION -1.899217466 0.000153472 0.004260216 GNAI1/KCNB1/PICK1/TMEM25/CBLN1/NLGN4X/GRIK3/LRRK2/SHANK3/PLK2/NPY5R/BCHE/PPP1R9A/PCDH17/GRIA1/ADIPOQ GOBP_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL -1.98556767 0.000115787 0.003512027 KCNA5/KCNJ2/PKP2/SLC4A3/SNTA1/GJC1/JUP/RYR2/KCNJ8/ATP1B1/KCNIP2/DSG2/CTNNA3/FGF12/ATP1A2/CAV1/CALM1/DMD/KCNJ3/FLNA/SLC8A1/DSP/GPD1L/SCN4B GOBP_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES -1.739654538 0.004838599 0.046645595 AJUBA/CDH8/CDH19/SELL/PCDH12/ARVCF/CDH2/SELP/CDH5 GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT -1.959017927 7.15E-05 0.002539595 CALM2/GPER1/CXCL11/SNCA/PLCG2/TRPC1/RYR2/ATP1B1/CXCL10/CASQ1/JPH2/CALM1/PKD2/THY1/CXCL9/EHD3/PLP1/RAMP3/APLNR GOBP_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_ENDOPLASMIC_RETICULUM -1.738944758 0.004492454 0.04419949 CALM2/RYR2/CASQ1/HRC/ATP1A2/CALM1/CCL3/DMD/SLC8A1/CLIC2/PLN/CASQ2 GOCC_ACTOMYOSIN -2.031661843 2.13E-05 0.001060719 MYH7/DAAM1/TRIP6/LIMA1/SYNPO2/PTK2/KAT2B/MYLK/MYL9/ILK/FSCN1/MYH6/NEBL/CNN2/ACTN4/ABLIM1/PGM5/PDLIM7/TPM1/FAM107A/TEK/LDB3/MYH10 GOBP_ACTIN_MEDIATED_CELL_CONTRACTION -2.156107251 8.64E-08 1.08E-05 LIMCH1/SRI/SCN2B/MYL3/KCNA5/KCNJ2/CCDC88C/EPB41L5/MYL4/TPM2/PKP2/SNTA1/GJC1/MYH7/MYL6/JUP/VIM/MYL2/TNNC1/RYR2/KCNJ8/MYBPC3/STC1/TCAP/TNNT2/EPDR1/DSG2/TNNI3/CTNNA3/FGF12/ATP1A2/CAV1/MYH6/DMD/KCNJ3/FLNA/DSP/TTN/GPD1L/PLN/SCN4B/TPM1/ACTN2/ACTC1/DES GOBP_MEMBRANE_DEPOLARIZATION -2.01839415 3.76E-05 0.001591243 BOK/LRRK2/IFI6/SCN3A/FGF12/ATP1A2/SCN9A/CAV1/EDN1/SLC8A1/GPD1L/JUN/SCN4B/FHL1/MYOC/SCN7A/KDR/DCN GOBP_SODIUM_ION_HOMEOSTASIS -1.805922253 0.001303471 0.018936871 AGTR2/EXT1/NPPB/ATP1B1/ATP1A2/EDNRB/EDN1/NPR1/ATP1B2/AGTR1/SLC8A1/AVPR1A/SCN7A/C7 GOBP_CARDIAC_MUSCLE_CONTRACTION -2.221302152 7.09E-09 1.52E-06 SRI/SCN2B/MYL3/TAZ/KCNA5/TNNI3K/KCNJ2/GSTM2/MYL4/PKP2/SNTA1/MIR30E/GJC1/CALM2/MYH7/MAP2K6/PIK3CG/VEGFB/JUP/CSRP3/TNNC1/RYR2/KCNJ8/ATP1B1/MYBPC3/STC1/TCAP/TNNT2/HRC/DSG2/TNNI3/CTNNA3/ADRA1B/FGF12/ATP1A2/CAV1/CALM1/MYH6/DMD/KCNJ3/FLNA/SLC8A1/DSP/TTN/CLIC2/GPD1L/PLN/NPPA/EHD3/SCN4B/TPM1/CASQ2/ACTC1 GOBP_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS -1.781466324 0.002481882 0.030013701 ADCY2/NPPB/PDE5A/PDE10A/ADCY9/PDE2A/ADCY5/ADCY1/ADCY4/NPR1/GUCY1A2/NPPA GOBP_REGULATION_OF_CARDIAC_CONDUCTION -1.899269745 0.000160831 0.004424999 TRPC1/RYR2/FXYD1/ATP1B1/CASQ1/ABCC9/RYR3/ATP1A2/DMPK/NPR1/ATP1B2/FXYD6/SLC8A1/NPPA/EHD3/CASQ2 GOCC_CONTRACTILE_FIBER -2.366589406 1.00E-10 3.66E-08 MYBPHL/PDLIM5/FHL5/MYPN/TRIM63/MTM1/MYL4/LMOD3/HABP4/TPM2/PPP1R12A/VCL/MYOZ1/PPP2R5A/OBSL1/MYZAP/CALM2/MYH7/FBP2/SYNPO2L/SYNPO2/MYOM2/SPTBN1/KAT2B/PSEN2/JUP/CSRP3/ABRA/MYL2/TNNC1/NRAP/RYR2/LMOD1/KCNJ8/FHL2/CALD1/MYBPC3/ARHGEF25/TCAP/FHOD3/TNNT2/CASQ1/HRC/SYNM/LMOD2/AHNAK/CFL2/ABCC9/CRYAB/FLNB/TNNI3/JPH2/RYR3/MYL9/ILK/KLHL41/SYNE1/CALM1/MYOT/MYH6/NEBL/DMD/MYL7/MYH11/CMYA5/FLNA/SLC8A1/PGM5/CSRP1/TTN/MYOM1/TMOD2/PDLIM7/SORBS2/NEXN/SYNC/TPM1/ACTN2/SMPX/FBXL22/LDB3/ACTA2/CASQ2/ACTC1/DES GOBP_POSITIVE_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT -1.893718994 0.00042869 0.008885305 MEF2A/KLF15/C2CD5/INSR/TCAF1/ACSL5/NR4A3/IGF1/GPC3/ADIPOQ/ITLN1/C3 GOCC_I_BAND -2.227793782 2.56E-09 6.12E-07 PDLIM5/FHL5/MYPN/TRIM63/MTM1/PPP1R12A/MYOZ1/PPP2R5A/OBSL1/MYZAP/MYH7/FBP2/SYNPO2L/SYNPO2/KAT2B/PSEN2/JUP/CSRP3/NRAP/RYR2/FHL2/TCAP/FHOD3/CASQ1/HRC/CFL2/CRYAB/FLNB/JPH2/RYR3/MYL9/MYOT/MYH6/NEBL/DMD/FLNA/SLC8A1/PGM5/CSRP1/TTN/PDLIM7/SORBS2/NEXN/SYNC/ACTN2/FBXL22/LDB3/CASQ2/ACTC1/DES GOCC_MYOSIN_COMPLEX -1.899663108 0.000382841 0.008152412 MYO6/MYL5/BMF/MYO3A/LIMCH1/MYL3/CGNL1/MYO1C/MYL4/MYH7/MYL6/MYL2/MYO1D/MYL12A/MYL12B/MYL9/MYO5B/MYH6/MYL7/MYH11/MYO5C/MYH10 GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY -1.941975531 9.87E-05 0.003228553 ERBB4/EPHA5/ROR2/INSR/EPHB3/FLT4/FGFR2/PDGFRL/EPHA7/ERBB3/EPHB4/EPHA3/TIE1/CRIM1/NTRK2/FLT1/TEK/KDR GOBP_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS -1.928025787 0.000189332 0.004884931 TGFBR1/MYL3/ZFPM2/ISL1/S1PR1/TBX20/PKP2/MYH7/NOTCH1/PROX1/WNT5A/MYL2/TNNC1/FGFR2/RYR2/MYBPC3/TCAP/TNNT2/TNNI3/FOXC1/MYH6/HEY2/DLL4/HEG1/DSP/TTN/TGFB2/TPM1/ACTC1 GOBP_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION -1.920668363 0.000109119 0.003392495 KCNA5/GJD3/TNNI3K/PKP2/GJC1/CALM2/JUP/RYR2/ATP1B1/HRC/DSG2/CTNNA3/ATP1A2/CAV1/CALM1/KCNJ3/ATP1B2/FLNA/SLC8A1/DSP/SCN4B/CASQ2 GOCC_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE -1.81281177 0.00164349 0.022709385 CD207/TYRP1/ROR2/HLA-DQB2/WNT5A/FZD2/FZD4/HLA-DQA1/HLA-DQB1/CD9/CD74/HLA-DRA/HLA-DPA1/HBEGF/HLA-DRB1/HLA-DQA2/APOB GOBP_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY -1.878185134 0.000571295 0.010650455 SEMA6B/SEMA5B/SEMA5A/PLXNB1/PLXNB3/SEMA3B/SEMA3E/PLXNA1/SEMA6A/SEMA3A/NCAM1/SEMA3C/FLNA/HAND2/SEMA3D/SEMA3G GOBP_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION -1.702090216 0.005348714 0.049787883 GPER1/BMP4/TBX5/SOX17/PRICKLE1/EFNB2/MEF2C/HEY2/FZD7/MIR145/TGFB2 GOBP_GLOMERULUS_DEVELOPMENT -1.961580404 3.62E-05 0.001552544 KLF15/BCL2/CD24/COL4A3/GPR4/EXT1/NOTCH1/BMP4/PDGFD/ENPEP/PDGFB/FOXC1/OSR1/MEF2C/ANGPT1/CD34/TEK/PROM1/ADIPOQ/ACTA2/PODXL/PECAM1 GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT -1.741169254 0.005066832 0.048527522 AKAP9/KCNH2/ALG10B/WNK2/ANO6/KCNJ2/KCNMB1/ATP1B1/KCNIP2/ATP1B2/FLNA/NPPA/ACTN2 GOBP_MEMBRANE_REPOLARIZATION -1.87917459 0.000489973 0.009764909 KCNA5/KCNJ2/SNTA1/KCNJ8/ATP1B1/KCNIP2/ATP1A2/ZMPSTE24/CAV1/KCNJ3/ATP1B2/FLNA/NPPA/SCN4B/CASQ2 GOBP_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT -1.936880526 0.000539088 0.010345831 TGFBR1/MYL3/ZFPM2/ISL1/PKP2/MYH7/NOTCH1/PROX1/MYL2/TNNC1/FGFR2/RYR2/MYBPC3/TBX5/TNNT2/DSG2/TNNI3/ZMPSTE24/FOXC1/MYH6/HEY2/DLL4/HEG1/DSP/TGFB2/TPM1 GOCC_INTRINSIC_COMPONENT_OF_POSTSYNAPTIC_DENSITY_MEMBRANE -1.838848333 0.00132368 0.019008405 PTPRS/GRID1/LRRC4/ABHD17B/CLSTN1/ERBB4/CLSTN2/SLITRK3/SLITRK1/NPTN/LRRC4B/EPHA7/ADCY1/ADAM22/GRIN2A/GRIA1/RGS7BP/GSG1L GOBP_REGULATION_OF_BMP_SIGNALING_PATHWAY -2.156401115 2.26E-07 2.42E-05 NOTCH1/WNT5A/NEO1/FSTL3/BMP4/HTRA1/TOB1/TWSG1/FST/SORL1/HTRA3/FSTL1/PPARG/ACVRL1/RBPMS2/SOST/SFRP1/CRIM1/GPC3/MIR140/CDH5/SFRP2/SFRP4/CHRDL1 GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT -2.352042955 1.00E-10 3.66E-08 EFEMP2/IMPG2/SRPX/CHADL/LAMA4/COL4A6/COL8A2/FBN2/COL4A3/POSTN/COL5A1/THBS3/COMP/LTBP4/LAMC1/AGRN/CILP/FMOD/FBLN5/NPNT/LAMA5/PXDN/COL16A1/PRELP/COL6A6/HSPG2/COL25A1/MMRN2/COL1A2/PRG4/ANOS1/LTBP2/COL4A5/VWA1/COL9A2/COLQ/COL28A1/SPARC/ACAN/MATN2/MFAP4/HAPLN1/SPON1/PODN/LUM/ELN/FGL2/FBLN2/COL21A1/TNXB/ABI3BP/HMCN1/COL12A1/COL10A1/COL15A1/SBSPON/MXRA5/FBLN1/TINAGL1/CTHRC1/OGN/MFAP5/DPT/ADIPOQ/LTBP1/ASPN/DCN/MMRN1/VWF GOBP_RENAL_SYSTEM_PROCESS -2.21392978 1.59E-08 2.99E-06 NPPB/MAGED2/ADCY9/KLHL3/BMP4/ADCY5/STC1/SUCNR1/ADCY1/HYAL2/PDGFB/EDNRB/IGKV3-20/ADCY4/MYO5B/EDN1/WFS1/KCNMA1/NPR1/AGTR1/MCAM/PRKAR2B/AVPR1A/GAS6/HBB/CD34/NPR3/BTC/IGHA1/IGHA2/ADIPOQ/ADGRF5/JCHAIN GOBP_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY -1.963646576 0.000133692 0.003866489 SKIL/BAMBI/NOTCH1/WNT5A/FSTL3/HTRA1/TOB1/TWSG1/SORL1/HTRA3/PPARG/RBPMS2/SOST/SFRP1/CRIM1/SFRP2/CHRDL1 GOBP_LEUKOCYTE_TETHERING_OR_ROLLING -1.735737554 0.003799461 0.039772811 ADD2/ITGB7/FUT4/GCNT1/ROCK1/SPN/SELPLG/JAM2/EXT1/LEP/SELE/PODXL2/SELL/SELP/CX3CR1/CCL21 GOBP_REGULATION_OF_MEMBRANE_REPOLARIZATION -1.754826022 0.003954887 0.040602875 SCN5A/AKAP9/KCNH2/SCN1B/KCNA5/KCNJ2/SNTA1/ZMPSTE24/CAV1/FLNA/NPPA/SCN4B/CASQ2 GOBP_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT -1.856801556 0.001092706 0.016571815 CALM2/RYR2/CASQ1/HRC/SLN/ATP1A2/ZMPSTE24/CALM1/CCL3/DMD/SLC8A1/CLIC2/PLN/CASQ2 GOCC_NEURON_PROJECTION_MEMBRANE -1.864725164 0.00100387 0.015566242 SGCE/MYO1C/ATP2B1/KCNB1/LAMP5/INSR/GABRA4/GPER1/SPTBN1/MYO1D/PALM/ITGA8/THY1/AKAP5/GRIA1 GOMF_ACTININ_BINDING -1.843499076 0.001726913 0.023599877 KCNA5/PDLIM5/MYPN/MAGI1/SYNPO2/CSRP3/NRAP/TRPC6/MYOT/PPARG/PKD2/CSRP1/TTN/PDLIM7/PROM1/LDB3 GOBP_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION -1.954705774 0.000151346 0.004220053 MME/IGSF11/CALB2/NPTN/PTN/SHANK3/ADCY1/ZDHHC2/PPP1R9A/RELN/AKAP5/FAM107A/CX3CR1 GOBP_MULTICELLULAR_ORGANISM_AGING -1.789020116 0.001839036 0.0246979 COQ7/INPP5D/TREX1/RAD54B/COMP/MSH2/LRRK2/LEP/CRYAB/HYAL2/ZMPSTE24/EDN1 GOCC_IMMUNOGLOBULIN_COMPLEX -2.316997803 3.29E-10 1.10E-07 IGHV3-20/IGHV1-24/IGHV2-70/IGHV3-66/IGHV4-4/IGKV1-6/IGLV2-11/IGKV1-16/IGHV5-51/SYK/IGHD/IGLV3-25/IGKV1D-33/IGHV3-72/IGLV1-47/IGKV1-9/IGHV3-48/IGHV3-21/IGLV1-40/IGKC/IGHV3-30/IGKV1-12/TRDC/IGHV1-18/IGLV3-19/IGKV6D-21/IGHV3-49/IGHG3/IGKV2-30/IGHV3-11/IGLC6/CD79B/IGLV5-52/IGKV1-5/IGHV3-33/IGLV2-14/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGLV2-23/IGHV3-23/IGKV3-20/IGHM/IGHV3-7/IGHG1/IGLJ1/IGHG2/IGKJ1/IGHA1/IGHA2/JCHAIN GOBP_REGULATION_OF_CELLULAR_EXTRAVASATION -1.844359094 0.002158245 0.0276131 PDGFD/PTGER4/PLCB1/BST1/SELE/XG/THY1/SELP/PLVAP/CCL21 GOCC_ACTIN_FILAMENT_BUNDLE -2.189496545 2.88E-07 2.94E-05 MYH7/DAAM1/TRIP6/LIMA1/SYNPO2/PTK2/MYLK/CRYAB/MYL9/ILK/FSCN1/MYH6/NEBL/PLS3/CNN2/FLNA/ACTN4/ABLIM1/PGM5/PDLIM7/TPM1/FAM107A/TEK/LDB3/MYH10 GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT -1.960395256 0.000171318 0.004631553 AKAP9/KCNH2/ALG10B/KIF5B/WNK2/ANO6/KCNJ2/KCNMB1/ATP1B1/STK39/ADRA2A/KCNIP2/ATP1B2/FLNA/NPPA/FHL1/ACTN2 GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT_CONFERRING_TENSILE_STRENGTH -1.986318715 8.28E-05 0.00284372 COL4A6/COL8A2/COL4A3/COL5A1/COL16A1/COL6A6/COL25A1/COL1A2/COL4A5/COL9A2/COL28A1/COL21A1/COL12A1/COL10A1/COL15A1 GOMF_FRIZZLED_BINDING -1.813656382 0.001378858 0.019664534 FZD1/CCDC88C/ROR2/BAMBI/WNT5A/WNT11/FZD7/RSPO3/SFRP1/CTHRC1/MYOC GOMF_PEPTIDE_HORMONE_BINDING -1.865712085 0.001669372 0.022914251 INSR/VIPR2/ADCYAP1R1/SLC40A1/EDNRB/CALCRL/NPR1/RAMP1/AVPR1A/NPR3/RAMP2 GOBP_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL -1.799567015 0.003718281 0.03938717 SCN3B/SCN5A/TRPM4/YWHAH/KCNH2/SCN1B/SCN2B/PTPN3/KCNJ2/SCN3A/ATP1A2/SCN9A/SLC8A1/SCN4B/SCN7A GOBP_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL -1.910146362 0.000661282 0.011607095 PKP2/SNTA1/JUP/RYR2/KCNJ8/DSG2/CTNNA3/CAV1/KCNJ3/DSP/GPD1L GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT -1.913247525 0.000652285 0.011588304 CALM2/ADRA2A/SLN/ATP1A2/CALM1/REM1/PKD2/CLIC2/PLN/GEM/CASQ2 GOBP_MYOFIBRIL_ASSEMBLY -2.133714517 1.66E-06 0.000134207 MYLK3/MYPN/LMOD3/MYOZ1/OBSL1/PROX1/SYNPO2L/CSRP3/MYL2/NRAP/LMOD1/TCAP/FHOD3/TNNT2/CASQ1/LMOD2/CFL2/KLHL41/MYH6/NEBL/EDN1/MYH11/PGM5/CSRP1/TTN/TMOD2/TPM1/ACTN2/LDB3/ACTC1 GOBP_T_CELL_CHEMOTAXIS -1.79340823 0.004733555 0.045917703 XCL2/PIK3CG/CXCL11/WNT5A/CCL5/CXCL10/STK39/CCL3/CCL21 GOBP_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL -1.958107356 0.000296512 0.006680115 CALM2/GPER1/CXCL11/SNCA/TRPC1/CXCL10/CASQ1/JPH2/CALM1/PKD2/THY1/CXCL9/APLNR GOBP_REGULATION_OF_RENAL_SYSTEM_PROCESS -1.837463928 0.002033168 0.026559322 CORO2B/INPP5K/AGTR2/NPPB/STC1/PDGFB/EDNRB/EDN1/NPR1/AGTR1/AVPR1A/GAS6/ADIPOQ GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL -2.07510167 2.87E-05 0.001294026 CALM2/GPER1/CXCL11/SNCA/TRPC1/CXCL10/CASQ1/JPH2/CAV1/CALM1/PKD2/THY1/CXCL9/RAMP3/APLNR GOBP_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT -1.84340994 0.001850005 0.024791658 GPR4/NOTCH1/BMP4/PDGFD/PDGFB/OSR1/ANGPT1/PKD2/CD34/TEK/ACTA2/PECAM1 GOBP_REGULATION_OF_LYASE_ACTIVITY -1.866966229 0.000707662 0.012189034 GUCA1B/ISCU/TIMP2/PALM/EDNRB/P2RY13/NOS3/CAP2/AKAP5/NPR3 GOMF_IMMUNOGLOBULIN_RECEPTOR_BINDING -2.162305583 7.36E-07 6.83E-05 FES/IGHV3-72/IGHV3-48/IGHV3-21/IGKC/IGHV3-30/TRDC/IGHV1-18/IGHV3-49/IGHG3/IGHV3-11/IGLC6/IGHV3-33/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGHV3-23/IGHM/IGHV3-7/FLNA/IGHG1/IGHG2/IGHA1/IGHA2/JCHAIN GOCC_MYOFILAMENT -1.842516168 0.001465764 0.020666944 MYBPHL/LMOD3/TPM2/TNNC1/LMOD1/MYBPC3/FHOD3/TNNT2/LMOD2/TNNI3/MYOM1/TMOD2/TPM1 GOBP_POSITIVE_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT -2.020738487 6.81E-05 0.002459172 MEF2A/KLF15/C2CD5/INSR/NR4A3/IGF1/GPC3/ADIPOQ/ITLN1/C3 GOMF_SEMAPHORIN_RECEPTOR_BINDING -1.832182996 0.002845009 0.032578757 SEMA6B/SEMA5B/SEMA5A/PLXNB1/SEMA3B/SEMA3E/SEMA6A/SEMA3A/SEMA3C/SEMA3D/SEMA3G GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION -1.818915741 0.003880966 0.040219742 GSTM2/CALM2/RYR2/HRC/ATP1A2/CALM1/DMD/SLC8A1/CLIC2/PLN/CASQ2 GOMF_WNT_PROTEIN_BINDING -1.9167438 0.000323251 0.007077382 APCDD1/SFRP5/ROR1/FZD1/ROR2/FZD2/FZD6/FZD8/FZD4/FZD7/FRZB/SFRP1/CTHRC1/SFRP2/SFRP4 GOMF_C_C_CHEMOKINE_BINDING -1.834137653 0.003172413 0.035288126 ACKR3/CX3CR1/ACKR4/ACKR1 GOBP_RESPONSE_TO_MUSCLE_STRETCH -1.835554033 0.003096428 0.034504637 PTK2/CSRP3/RYR2/TCAP/DMD/EDN1/SLC8A1/TTN/NPPA/CDH2/FOS GOBP_PROTEIN_CONTAINING_COMPLEX_REMODELING -1.868826302 0.001013512 0.015676654 LCAT/AGTR1/MTTP/APOB/GPIHBP1/LPL/PLA2G2A GOBP_SLEEP -1.792500909 0.003725688 0.039398512 SRD5A1/ADA/ADRB1/GRIN2A/PER3/PTGDS/FOS GOBP_SARCOMERE_ORGANIZATION -2.083781057 1.91E-05 0.000958942 MYLK3/MYPN/MYOZ1/PROX1/SYNPO2L/CSRP3/TCAP/FHOD3/TNNT2/CASQ1/LMOD2/CFL2/KLHL41/MYH6/EDN1/CSRP1/TTN/TPM1/ACTN2/LDB3 GOCC_A_BAND -2.043336714 6.35E-05 0.002335153 RPL15/MYL3/TRIM63/MYL4/LMOD3/PPP1R12A/PPP2R5A/OBSL1/MYOM2/SPTBN1/KAT2B/MYL2/FHL2/MYBPC3/LMOD2/CRYAB/KLHL41/MYL7/CMYA5/MYOM1/SMPX GOCC_M_BAND -1.887806573 0.001321773 0.019008405 TRIM63/LMOD3/PPP2R5A/OBSL1/MYOM2/SPTBN1/FHL2/LMOD2/CRYAB/KLHL41/CMYA5/MYOM1/SMPX GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS -1.995734799 0.000103406 0.003280502 DDHD2/PNPLA4/PIK3CG/LIPE/PNPLA2/SORL1/MGLL/GPLD1/APOB/LPL/FABP3/FABP4 GOCC_IMMUNOGLOBULIN_COMPLEX_CIRCULATING -2.230473689 7.00E-08 1.01E-05 IGHV3-48/IGHV3-21/IGKC/IGHV3-30/TRDC/IGHV1-18/IGHV3-49/IGHG3/IGHV3-11/IGLC6/IGHV3-33/TRBC2/IGHG4/IGHV4-39/IGHV4-59/IGHV3-23/IGKV3-20/IGHM/IGHV3-7/IGHG1/IGHG2/IGHA1/IGHA2/JCHAIN GOBP_EMBRYONIC_HINDLIMB_MORPHOGENESIS -1.88374082 0.001491405 0.020865554 RARG/NOTCH1/OSR2/RSPO2/BMP4/OSR1/RARB/AFF3/GPC3 GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY -1.979609695 0.000101284 0.003280139 CALM2/ADRA2A/SLN/ATP1A2/CALM1/REM1/PKD2/CLIC2/PLN/GEM/CASQ2 GOMF_CHEMOREPELLENT_ACTIVITY -1.98580999 0.000121623 0.003601211 SEMA6B/SEMA5B/SEMA5A/FLRT2/FLRT3/SEMA3B/SEMA3E/SEMA6A/EPHA7/SEMA3A/DPP4/SEMA3C/SEMA3D/SEMA3G GOBP_REGULATION_OF_CELL_FATE_COMMITMENT -1.919737922 0.000806888 0.013242619 LMO4/WNT5A/AR/WNT11/BMP4/SOX17/FZD7/SFRP2 GOBP_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY -1.937553093 0.000390582 0.008286767 WNT5A/DACT1/RSPO3/SFRP1/NKD1/ANKRD6/GPC3/SFRP2/SFRP4 GOBP_REGULATION_OF_EXCRETION -1.75034463 0.004085896 0.041482998 AGTR2/NPPB/STC1/EDNRB/EDN1/NPR1/AGTR1/AVPR1A GOBP_REGULATION_OF_CYCLASE_ACTIVITY -1.980511602 0.000218879 0.005362826 TIMP2/PALM/EDNRB/P2RY13/NOS3/CAP2/AKAP5/NPR3 GOMF_TRIGLYCERIDE_LIPASE_ACTIVITY -1.894799401 0.001710996 0.023433861 DDHD2/PNPLA4/PLA1A/LIPE/LCAT/PNPLA2/CES1/LPL GOBP_PULMONARY_VALVE_MORPHOGENESIS -1.778559277 0.003040015 0.034079744 TBX20/NOTCH1/HEY1/BMP4/SLIT2/HEY2/NOS3/TGFB2 GOCC_MHC_PROTEIN_COMPLEX -1.960350284 0.000364333 0.007811795 HLA-E/HLA-DPB1/HLA-DOB/HLA-B/HLA-DQB2/HLA-DQA1/HLA-DQB1/HLA-DMA/CD74/HLA-DRA/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DOA/HLA-DQA2 GOBP_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION -1.784400725 0.003065052 0.034216328 GSTP1/C1QTNF3/ADIPOQ/APOD GOBP_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS -1.875841764 0.001448069 0.020463847 ADCY3/ADCY2/NPPB/ADCY9/ADCY5/ADCY1/ADCY4/NPR1/GUCY1A2/NPPA GOBP_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION -1.856329265 0.002362862 0.029301195 SOX9/HOXB4/PTN/TBX5/FOXC1/RBM24/TGFB2 GOBP_POSITIVE_REGULATION_OF_CARDIOCYTE_DIFFERENTIATION -1.798487446 0.002557239 0.030415414 GPER1/BMP4/TBX5/EFNB2/MEF2C/MIR145/TGFB2 GOBP_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION -1.863291376 0.002216331 0.028124792 BTG2/APPL2/SIRT2/RAPGEF1/GATA2/WNT5A/PTN/SPINT2/LIMS2 GOBP_DETERMINATION_OF_ADULT_LIFESPAN -1.864581611 0.002179699 0.027773291 COQ7/INPP5D/TREX1/RAD54B/MSH2/LRRK2/LEP/ZMPSTE24 GOBP_REGULATION_OF_AMPA_RECEPTOR_ACTIVITY -1.822953216 0.001735241 0.023661683 NLGN3/SHANK3/ADRB2/MEF2C/RELN/GSG1L GOBP_GLOMERULAR_EPITHELIUM_DEVELOPMENT -1.966162828 0.000541736 0.010364668 KLF15/CD24/EXT1/BMP4/FOXC1/CD34/PROM1/ADIPOQ/PODXL/PECAM1 GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS -2.021394197 0.000116615 0.003519963 DDHD2/PNPLA4/PIK3CG/LIPE/PNPLA2/SORL1/MGLL/GPLD1/APOB/LPL/FABP3/FABP4 GOMF_CYCLASE_ACTIVITY -1.92535786 0.000601164 0.010834889 ADCY3/ADCY2/ADCY9/ADCY5/ADCY1/BST1/ADCY4/NPR1/GUCY1A2 GOBP_MUSCLE_FILAMENT_SLIDING -2.203194868 1.00E-06 8.90E-05 MYL4/TPM2/MYH7/MYL6/VIM/MYL2/TNNC1/MYBPC3/TCAP/TNNT2/TNNI3/MYH6/DMD/TTN/TPM1/ACTN2/ACTC1/DES GOBP_CGMP_METABOLIC_PROCESS -1.829928882 0.003748722 0.039507719 NPPB/PDE5A/PDE10A/PDE2A/NPR1/GUCY1A2/NPPA GOMF_STRUCTURAL_CONSTITUENT_OF_MUSCLE -2.337192705 8.17E-08 1.08E-05 SMTN/MYL6/MYOM2/CSRP3/MYL2/MYBPC3/TCAP/SYNM/MYL9/MYOT/NEBL/DMD/MYH11/CSRP1/TTN/MYOM1/SORBS2/NEXN/TPM1/ACTN2 GOCC_DYNACTIN_COMPLEX -1.820443625 0.002066027 0.026875641 ACTR10/DCTN2/ACTR1B/ACTG2/ACTA2/ACTC1 GOBP_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY -1.82588165 0.001917128 0.02541728 C3/C7/CFD GOBP_CONVERGENT_EXTENSION -1.887728954 0.000597126 0.010824861 WNT5A/WNT11/FRZB/SFRP1/NKD1/SFRP2 GOBP_REGULATION_OF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY -1.788935813 0.004741418 0.045922329 SRI/CALM1/REM1/NPPA/GEM GOBP_RENAL_FILTRATION -2.103425705 2.77E-05 0.001267846 PDGFB/IGKV3-20/MCAM/GAS6/CD34/IGHA1/IGHA2/ADGRF5/JCHAIN GOBP_REGULATION_OF_LEUKOCYTE_TETHERING_OR_ROLLING -1.793961769 0.004442752 0.043849258 SELE/SELP/CCL21 GOBP_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY -1.977977388 0.000282001 0.006376305 TIMP2/PALM/EDNRB/P2RY13/CAP2/AKAP5/NPR3 GOBP_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL -1.853099233 0.00126871 0.018693926 PKP2/JUP/RYR2/DSG2/CTNNA3/CAV1/DSP GOBP_ADULT_HEART_DEVELOPMENT -1.81684852 0.003436406 0.0373559 MYH7/SCUBE1/TCAP/MYH6/HAND2/APLNR GOBP_DENDRITIC_CELL_APOPTOTIC_PROCESS -1.78277365 0.003517473 0.037996082 CCL19/GAS6/CCL21 GOBP_SYNAPSE_PRUNING -1.829119364 0.002804857 0.032297415 C1QA/CX3CR1/C3 GOBP_NEGATIVE_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY -1.795126445 0.002517592 0.030162599 CALM1/REM1/GEM GOBP_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION -1.809825919 0.001910525 0.025383857 AGTR2/NPPB/EDNRB/EDN1/NPR1/AVPR1A GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY -1.977542754 9.16E-05 0.003093858 DACT1/RSPO3/SFRP1/NKD1/ANKRD6/GPC3/SFRP2 GOBP_OTIC_VESICLE_DEVELOPMENT -1.81859111 0.001785629 0.024084685 AHI1/HESX1/SIX1/SOX9/PROX1/FGFR2/TCAP/FGF10 GOCC_MHC_CLASS_II_PROTEIN_COMPLEX -1.964095032 0.000103406 0.003280502 HLA-DQB2/HLA-DQA1/HLA-DQB1/HLA-DMA/CD74/HLA-DRA/HLA-DMB/HLA-DPA1/HLA-DRB1/HLA-DOA/HLA-DQA2 GOBP_DETECTION_OF_CALCIUM_ION -1.878301559 0.001062832 0.01619777 KCNMB2/KCNMB1/CALM2/KCNMB4/RYR2/KCNIP2/CALM1/CASQ2 GOBP_KERATAN_SULFATE_CATABOLIC_PROCESS -1.885627945 0.000970414 0.015199084 FMOD/PRELP/ACAN/LUM/OMD/OGN GOBP_ESTABLISHMENT_OF_PLANAR_POLARITY_OF_EMBRYONIC_EPITHELIUM -1.928541524 0.000254465 0.005882633 WNT5A/FZD2/SFRP1/CTHRC1/SFRP2 GOBP_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE -1.900226582 0.000657554 0.011607095 WNT5A/FZD2/SFRP1/CTHRC1/SFRP2 GOBP_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY -1.953114063 0.000142575 0.004048099 PALM/EDNRB/P2RY13/AKAP5/NPR3 GOBP_NEGATIVE_REGULATION_OF_PROTEIN_IMPORT -1.874272404 0.000614388 0.011041223 FERMT1/MDFIC/RAB23/ANGPT1/APOD GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT_CONFERRING_COMPRESSION_RESISTANCE -2.139962645 5.23E-06 0.000325209 FMOD/PRELP/HSPG2/PRG4/ACAN/HAPLN1/PODN/LUM/OGN/ASPN/DCN GOCC_MYOSIN_FILAMENT -2.07711551 6.54E-06 0.000398689 MYH7/MYOM2/MYBPC3/MYH6/ACTG2/MYH11/MYOM1/MYH10 GOBP_NEPHRIC_DUCT_DEVELOPMENT -1.926419084 0.000200234 0.005020392 PKD1/WNT11/EPHA7/BMP4/OSR1/PKD2/GPC3 GOBP_REGULATION_OF_CELL_FATE_SPECIFICATION -1.990995231 3.44E-05 0.00149268 LMO4/WNT5A/AR/WNT11/SOX17/FZD7/SFRP2