Supplementary file 11. Positional candidate genes in Eaa11 and Eaa19,,,,,,,,,,,,,
,,,,,,,,,,,,,
,,,,,,,,,,,,negative in B high; positive is D high,
,Gene,EnsembleID,Gene_ID,Description,Chr,Mb,EAA.Log10FishersCombinedP (df = 14),Predicted-maxLS (-Log10p),Missense/stop,cis-eQTL,cis-eQTL LOD (interval mapping),AdditiveEffect (interval mapping),HumanGWAS
1,Tmem100,ENSMUST00000092788,67888,transmembrane protein 100,11,90.03,3,0,missense,,,,
2,Mmd,ENSMUST00000004050,67468,monocyte to macrophage differentiation-associated,11,90.25,3,0,,yes,7.4,-0.164,age of menarche
3,Stxbp4,ENSMUST00000143203,20913,syntaxin binding protein 4,11,90.48,3,0,missense,yes,6.1,0.044,"epigenetic aging, age of menarch"
4,Cox11,ENSMUST00000020851,69802,cytochrome c oxidase assembly protein 11,11,90.64,5,0,missense,,,,
5,Tom1l1,ENSMUST00000107867,71943,target of myb1-like 1 (chicken),11,90.65,5,0,missense,yes,2.7,0.054,parental longevity
6,Mbtd1,ENSMUST00000107853,103537,mbt domain containing 1,11,93.89,11,0,missense,,,,
7,Ankrd40,ENSMUST00000051221,71452,ankyrin repeat domain 40,11,94.33,11,0,missense,,,,
8,Zfp652,ENSMUST00000107717,268469,zinc finger protein 652,11,95.71,8,0,,yes,8.8,-0.207,
9,Abi3,ENSMUST00000059026,66610,"ABI gene family, member 3",11,95.83,8,0,missense,,,,Alzheimer's diseae
10,B4galnt2,ENSMUST00000038343,14422,"beta-1,4-N-acetyl-galactosaminyl transferase 2",11,95.87,8,0,,yes,2.3,-0.032,
11,Calcoco2,ENSMUST00000097162,76815,calcium binding and coiled-coil domain 2,11,96.10,8,0,missense,,,,
12,Skap1,ENSMUST00000071510,78473,src family associated phosphoprotein 1,11,96.46,8,0,missense,,,,
13,Sp2,ENSMUST00000062652,78912,Sp2 transcription factor,11,96.95,7,0,missense,,,,
14,Plxdc1,ENSMUST00000017561,72324,plexin domain containing 1,11,97.92,7,0,,yes,9.9,0.126,
15,Cacnb1,ENSMUST00000107562,12295,"calcium channel, voltage-dependent, beta 1 subunit",11,98.00,7,0,,yes,2.6,-0.05,
16,Stac2,ENSMUST00000017544,217154,SH3 and cysteine rich domain 2,11,98.04,7,0,missense,yes,26.7,0.191,
17,Med1,ENSMUST00000092735,19014,mediator complex subunit 1,11,98.15,5,0,missense,,,,
18,Cdk12,ENSMUST00000107538,69131,cyclin-dependent kinase 12,11,98.20,5,0,missense,,,,age of menopause
19,Erbb2,ENSMUST00000058295,13866,"v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)",11,98.41,5,0,missense,,,,
20,Grb7,ENSMUST00000019456,14786,growth factor receptor bound protein 7,11,98.45,5,0,,yes,5.3,-0.104,
21,Ikzf3,ENSMUST00000103141,22780,IKAROS family zinc finger 3,11,98.46,5,0,missense,,,,
22,Ormdl3,ENSMUST00000052919,66612,ORM1-like 3 (S. cerevisiae),11,98.58,5,0,,yes,3.9,-0.079,
23,Nr1d1,ENSMUST00000064941,217166,"nuclear receptor subfamily 1, group D, member 1",11,98.77,5,0,missense,,,,
24,Rapgefl1,ENSMUST00000107479,268480,Rap guanine nucleotide exchange factor (GEF)-like 1,11,98.84,5,0,,yes,9,0.078,
25,Marchf5,ENSMUST00000024078,69104,membrane-associated ring finger (C3HC4) 5,19,37.21,4,0,missense; stop,,,,
26,Kif11,ENSMUST00000012587,16551,kinesin family member 11,19,37.38,4,0,missense,,,,
27,Cyp26c1,ENSMUST00000073391,546726,"cytochrome P450, family 26, subfamily c, polypeptide 1",19,37.69,4,0,missense,,,,
28,Cyp26a1,ENSMUST00000025946,13082,"cytochrome P450, family 26, subfamily a, polypeptide 1",19,37.70,4,0,missense,,,,longevity
29,Myof,ENSMUST00000041475,226101,myoferlin,19,37.90,9,0,missense,,,,longevity
30,Cep55,ENSMUST00000116506,74107,centrosomal protein 55,19,38.06,5,1,missense,,,,
31,Fra10ac1,ENSMUST00000067167,70567,FRA10AC1 homolog (human),19,38.19,11,1,,yes,23.3,-0.161,
32,Slc35g1,ENSMUST00000054098,240660,"solute carrier family 35, member G1",19,38.40,11,1,,yes,9.2,-0.211,
33,Plce1,ENSMUST00000182267,74055,"phospholipase C, epsilon 1",19,38.52,11,1,missense,yes,5.4,-0.128,
34,Noc3l,ENSMUST00000025963,57753,nucleolar complex associated 3 homolog (S. cerevisiae),19,38.79,11,1,missense,,,,
35,Cyp2c65,ENSMUST00000087236,72303,"cytochrome P450, family 2, subfamily c, polypeptide 65",19,39.06,11,1,missense,,,,
36,Cyp2c66,ENSMUST00000087234,69888,"cytochrome P450, family 2, subfamily c, polypeptide 66",19,39.11,11,1,,yes,31.4,0.087,
37,Cyp2c29,ENSMUST00000003137,13095,"cytochrome P450, family 2, subfamily c, polypeptide 29",19,39.29,11,1,missense,,,,
38,Cyp2c38,ENSMUST00000035488,13097,"cytochrome P450, family 2, subfamily c, polypeptide 38",19,39.39,11,1,missense,,,,
39,Cyp2c39,ENSMUST00000025968,13098,"cytochrome P450, family 2, subfamily c, polypeptide 39",19,39.51,11,1,missense,yes,76.1,1.87,
40,Cyp2c67,ENSMUST00000067328,545288,"cytochrome P450, family 2, subfamily c, polypeptide 67",19,39.61,11,1,missense,,,,
41,Cyp2c68,ENSMUST00000099472,433247,"cytochrome P450, family 2, subfamily c, polypeptide 68",19,39.69,11,1,missense,yes,31.1,-0.419,
42,Cyp2c40,ENSMUST00000160476,13099,"cytochrome P450, family 2, subfamily c, polypeptide 40",19,39.77,11,1,missense,,,,
43,Cyp2c69,ENSMUST00000168838,100043108,"cytochrome P450, family 2, subfamily c, polypeptide 69",19,39.84,11,1,missense,yes,12.8,-0.789,
44,Cyp2c37,ENSMUST00000049178,13096,"cytochrome P450, family 2. subfamily c, polypeptide 37",19,39.99,11,1,missense,,,,
45,Cyp2c50,ENSMUST00000068094,107141,"cytochrome P450, family 2, subfamily c, polypeptide 50",19,40.09,11,1,missense,,,,
46,Cyp2c70,ENSMUST00000051846,226105,"cytochrome P450, family 2, subfamily c, polypeptide 70",19,40.15,11,1,missense,yes,6,0.27,
47,Sorbs1,ENSMUST00000165469,20411,sorbin and SH3 domain containing 1,19,40.30,11,1,missense,,,,
48,Aldh18a1,ENSMUST00000176939,56454,"aldehyde dehydrogenase 18 family, member A1",19,40.55,9,2,missense,,,,
49,Tctn3,ENSMUST00000025981,67590,tectonic family member 3,19,40.60,8,2,missense,,,,
50,Ccnj,ENSMUST00000120057,240665,cyclin J,19,40.83,8,2,missense,yes,4.1,0.053,age of menopause
51,Gm340,,,,19,41.58,8,2,missense,,,,
52,Slit1,ENSMUST00000025993,20562,slit homolog 1 (Drosophila),19,41.60,8,2,missense,,,,
53,Rrp12,ENSMUST00000038677,107094,ribosomal RNA processing 12 homolog (S. cerevisiae),19,41.86,8,2,missense,,,,
54,Mms19,ENSMUST00000026168,72199,MMS19 (MET18 S. cerevisiae),19,41.94,7,2,missense,,,,
55,Ankrd2,ENSMUST00000026172,56642,ankyrin repeat domain 2 (stretch responsive muscle),19,42.04,7,2,,yes,39.7,-0.572,
56,4933411K16Rik,ENSMUST00000164518,66765,RIKEN cDNA 4933411K16 gene,19,42.05,7,2,missense,,,,
57,Hoga1,ENSMUST00000172244,67432,4-hydroxy-2-oxoglutarate aldolase 1,19,42.05,7,2,stop,,,,
58,Pi4k2a,ENSMUST00000066778,84095,phosphatidylinositol 4-kinase type 2 alpha,19,42.09,7,2,,yes,17,-0.139,
59,Crtac1,ENSMUST00000048630,72832,cartilage acidic protein 1,19,42.28,9,1,,yes,4.1,0.01,
60,R3hcc1l,ENSMUST00000160107,52013,R3H domain and coiled-coil containing 1 like,19,42.52,3,3,missense,,,,
61,Loxl4,ENSMUST00000026190,67573,lysyl oxidase-like 4,19,42.59,3,3,missense,yes,13.8,-0.267,
62,Pyroxd2,ENSMUST00000076505,74580,pyridine nucleotide-disulphide oxidoreductase domain 2,19,42.73,3,3,missense,yes,20.8,0.272,
63,Hps1,ENSMUST00000026194,192236,Hermansky-Pudlak syndrome 1 homolog (human),19,42.76,3,3,missense,,,,
64,Cnnm1,ENSMUST00000165311,83674,cyclin M1,19,43.44,3,3,missense,yes,22.6,-0.166,
65,Got1,ENSMUST00000026196,14718,"glutamic-oxaloacetic transaminase 1, soluble",19,43.50,3,3,missense,,,,
66,Nkx2-3,ENSMUST00000057178,18089,NK2 homeobox 3,19,43.61,3,3,missense,,,,epigenetic aging
67,Slc25a28,ENSMUST00000046038,246696,"solute carrier family 25, member 28",19,43.66,3,3,,yes,2.2,-0.064,
68,Cutc,ENSMUST00000112047,66388,cutC copper transporter homolog (E.coli),19,43.75,3,3,,yes,37.6,-0.189,epigenetic aging
69,Abcc2,ENSMUST00000026208,12780,"ATP-binding cassette, sub-family C (CFTR/MRP), member 2",19,43.78,3,3,missense,yes,11.8,-0.351,
70,Dnmbp,ENSMUST00000026209,71972,dynamin binding protein,19,43.85,3,3,missense,,,,
71,Cpn1,ENSMUST00000026210,93721,"carboxypeptidase N, polypeptide 1",19,43.96,3,3,,yes,18.2,0.176,
72,Cyp2c44,ENSMUST00000026211,226143,"cytochrome P450, family 2, subfamily c, polypeptide 44; (BXD Mendelian reference 19.44, high B)",19,44.01,3,3,,yes,75.9,-1.379,
73,Erlin1,ENSMUST00000112028,226144,ER lipid raft associated 1,19,44.03,3,3,,yes,9.6,0.147,
74,Chuk,ENSMUST00000119591,12675,conserved helix-loop-helix ubiquitous kinase,19,44.07,3,3,missense,,,,age of menopause
75,Cwf19l1,ENSMUST00000026218,72502,"CWF19-like 1, cell cycle control (S. pombe)",19,44.11,3,3,missense,,,,
76,Pkd2l1,ENSMUST00000042026,329064,polycystic kidney disease 2-like 1,19,44.15,3,3,missense,,,,parental longevity
77,Scd4,ENSMUST00000058856,329065,stearoyl-coenzyme A desaturase 4,19,44.33,3,6,missense,,,,
78,Sec31b,ENSMUST00000111985,240667,Sec31 homolog B (S. cerevisiae),19,44.52,3,6,missense,,,,
79,Hif1an,ENSMUST00000040455,319594,"hypoxia-inducible factor 1, alpha subunit inhibitor",19,44.56,3,6,missense,,,,
80,Fam178a,ENSMUST00000096053,226151,"family with sequence similarity 178, member A",19,44.93,3,6,missense,,,,
81,Lzts2,ENSMUST00000039016,226154,"leucine zipper, putative tumor suppressor 2",19,45.02,3,6,missense,,,,
82,Pdzd7,ENSMUST00000145391,100503041,PDZ domain containing 7,19,45.03,3,6,missense,,,,
83,Hps6,ENSMUST00000099393,20170,Hermansky-Pudlak syndrome 6,19,46.00,3,6,missense,,,,
84,Ldb1,ENSMUST00000185355,16825,LIM domain binding 1,19,46.03,3,6,,yes,12.99751155,-0.208,
85,Pprc1,ENSMUST00000111899,226169,"peroxisome proliferative activated receptor, gamma, coactivator-related 1",19,46.06,3,6,missense,,,,
86,Nolc1,ENSMUST00000165017,70769,nucleolar and coiled-body phosphoprotein 1,19,46.08,3,6,missense,,,,
87,Elovl3,ENSMUST00000043739,12686,"elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3",19,46.13,3,6,,yes,8.429067245,0.386,
88,Pitx3,ENSMUST00000026259,18742,paired-like homeodomain transcription factor 3,19,46.14,3,6,,yes,7.063226157,0.057,
89,Psd,ENSMUST00000041391,73728,pleckstrin and Sec7 domain containing,19,46.31,3,6,,yes,11.34165708,0.112,
90,Sfxn2,ENSMUST00000026011,94279,sideroflexin 2,19,46.57,1,7,missense,yes,19.42368585,0.206,
91,Wbp1l,ENSMUST00000111855,226178,WW domain binding protein 1 like,19,46.62,1,7,,yes,3.243205365,0.1,
92,2010012O05Rik,ENSMUST00000074912,66439,RIKEN cDNA 2010012O05 gene,19,46.69,1,7,missense,yes,10.0654752,0.107,
93,As3mt,ENSMUST00000003655,57344,arsenic (+3 oxidation state) methyltransferase,19,46.71,1,7,missense,,,,
94,Cnnm2,ENSMUST00000099373,94219,cyclin M2,19,46.76,1,7,missense,,,,
95,Ina,ENSMUST00000037636,226180,"internexin neuronal intermediate filament protein, alpha",19,47.01,1,7,missense,,,,
96,Pcgf6,ENSMUST00000026032,71041,polycomb group ring finger 6,19,47.03,1,7,,yes,9.570832559,0.103,
97,Pdcd11,ENSMUST00000072141,18572,programmed cell death 11,19,47.09,1,7,missense,,,,
98,Neurl1a,ENSMUST00000111808,18011,neuralized E3 ubiquitin protein ligase 1A,19,47.18,1,7,missense,,,,
99,Obfc1,ENSMUST00000182808,108689,oligonucleotide/oligosaccharide-binding fold containing 1,19,47.51,1,7,,yes,7.88765915,0.09,
100,Slk,ENSMUST00000026043,20874,STE20-like kinase,19,47.58,1,7,,yes,5.911601924,0.183,
101,Col17a1,ENSMUST00000086923,12821,"collagen, type XVII, alpha 1",19,47.65,1,7,missense,yes,7.094092454,0.033,
102,Sfr1,ENSMUST00000099353,67788,SWI5 dependent recombination repair 1,19,47.73,1,7,missense,yes,33.79730104,0.202,
103,Cfap43,ENSMUST00000160247,100048534,cilia and flagella associated protein 43,19,47.74,1,7,missense,,,,
104,Gsto1,ENSMUST00000026050,14873,glutathione S-transferase omega 1,19,47.85,1,7,,yes,20.25176394,-0.205,
105,Gsto2,ENSMUST00000056159,68214,glutathione S-transferase omega 2,19,47.87,1,7,,yes,17.53157646,0.098,