Category GeneSet N_genes N_overlap p adjP genes link GO_bp GO_IMMUNE_SYSTEM_DEVELOPMENT 941 22 2.3300153413575076e-07 0.0017125612758977682 PRMT6:NOTCH2:FGFR2:TYR:SH2B3:PTPN11:IREB2:PSMA4:FES:FANCA:KAT2A:STAT5B:BCL3:CASP8:ASXL1:IRF4:HIST1H4F:HIST1H3G:HIST1H4H:FOXO3:HDAC9:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_DEVELOPMENT GO_bp GO_MYELOID_CELL_DIFFERENTIATION 397 13 2.4250008349878745e-06 0.00891187806858044 PRMT6:NOTCH2:PTPN11:IREB2:FES:STAT5B:CASP8:IRF4:HIST1H4F:HIST1H3G:HIST1H4H:FOXO3:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_MYELOID_CELL_DIFFERENTIATION GO_bp GO_DNA_PACKAGING 195 9 6.184424043797258e-06 0.00930998193606045 CHMP1A:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_DNA_PACKAGING GO_bp GO_CHROMOSOME_ORGANIZATION 1160 22 7.350247494669371e-06 0.00930998193606045 PRMT6:PSRC1:DCLRE1B:TCF7L2:ZW10:MAPKAPK5:CHMP1A:PRDM7:KAT2A:ASXL1:IRF4:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:MAP3K4:HDAC9:TWIST1:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION GO_bp GO_CHROMATIN_ASSEMBLY 152 8 7.930759206092852e-06 0.00930998193606045 HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY GO_bp GO_BEHAVIORAL_RESPONSE_TO_NICOTINE 7 3 9.790395123331899e-06 0.00930998193606045 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_NICOTINE GO_bp GO_REGULATION_OF_HEMOPOIESIS 452 13 9.873166459579351e-06 0.00930998193606045 PRMT6:NOTCH2:PSMA4:FES:FANCA:KAT2A:STAT5B:CASP8:IRF4:HIST1H4F:HIST1H3G:HIST1H4H:FOXO3 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMOPOIESIS GO_bp GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY 21 4 1.013331367190253e-05 0.00930998193606045 FURIN:APOC1:HDAC9:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY GO_bp GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION 49 5 1.792586386315629e-05 0.014639455488244303 APOE:APOC1:PLAGL2:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION GO_bp GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS 85 6 2.1581632170435915e-05 0.015302850724872342 LDLR:APOE:APOC1:PLAGL2:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS GO_bp GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_CLEARANCE 9 3 2.3269441882912182e-05 0.015302850724872342 LDLR:APOE:APOC1 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_CLEARANCE GO_bp GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY 178 8 2.4984246081424233e-05 0.015302850724872342 HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY GO_bp GO_TELOMERE_CAPPING 55 5 3.1679105033810316e-05 0.016686378816876936 DCLRE1B:MAPKAPK5:HIST1H4F:HIST1H4H:MAP3K4 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_TELOMERE_CAPPING GO_bp GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION 242 9 3.452000008746926e-05 0.016686378816876936 PRMT6:NOTCH2:FES:STAT5B:CASP8:HIST1H4F:HIST1H3G:HIST1H4H:FOXO3 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION GO_bp GO_MEGAKARYOCYTE_DIFFERENTIATION 93 6 3.602299518645112e-05 0.016686378816876936 PRMT6:PTPN11:HIST1H4F:HIST1H3G:HIST1H4H:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DIFFERENTIATION GO_bp GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC 29 4 3.859434556284461e-05 0.016686378816876936 CHRNA5:CHRNA3:CHRNB4:APOE http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC GO_bp GO_PROTEIN_CONTAINING_COMPLEX_REMODELING 29 4 3.859434556284461e-05 0.016686378816876936 APOE:APOC1:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_PROTEIN_CONTAINING_COMPLEX_REMODELING GO_bp GO_CELL_AGING 103 6 6.402230578749835e-05 0.02614244152989516 PRMT6:NOX4:MAPKAPK5:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CELL_AGING GO_bp GO_CELLULAR_SENESCENCE 65 5 7.13397920978958e-05 0.02699304992176958 PRMT6:MAPKAPK5:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CELLULAR_SENESCENCE GO_bp GO_ORGANIC_CATION_TRANSPORT 34 4 7.345047597760429e-05 0.02699304992176958 CHRNA3:SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSPORT GO_bp GO_REGULATION_OF_CELL_DIFFERENTIATION 1762 26 7.962672501820373e-05 0.027869353756371305 PRAMEF12:PRAMEF1:PRMT6:NOTCH2:TCF7L2:FGFR2:PSMA4:CHRNA3:FES:FANCA:KAT2A:STAT5B:LDLR:APOE:BCL11A:CASP8:ASXL1:IRF4:HIST1H4F:HIST1H3G:HIST1H4H:TTBK1:FOXO3:HDAC9:TWIST1:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIFFERENTIATION GO_bp GO_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY 1806 26 0.00011935696774763118 0.03987607786114041 PSRC1:TCF7L2:ZW10:NDUFA12:ATXN2:RPL6:PTPN11:CHRNA3:CHRNB4:FES:FANCA:SPIRE2:APOE:APOC1:CASP8:TM9SF4:PLAGL2:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:TTBK1:SLC22A1 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY GO_bp GO_NUCLEOSOME_ORGANIZATION 168 7 0.0001307856651244399 0.040195230365271346 HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_NUCLEOSOME_ORGANIZATION GO_bp GO_DNA_CONFORMATION_CHANGE 288 9 0.00013124973180496767 0.040195230365271346 CHMP1A:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_DNA_CONFORMATION_CHANGE GO_bp GO_CHROMATIN_ORGANIZATION 758 15 0.0001521944973642941 0.04374379851139481 PRMT6:PRDM7:KAT2A:ASXL1:IRF4:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:HDAC9:TWIST1:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CHROMATIN_ORGANIZATION GO_bp GO_TRIGLYCERIDE_METABOLIC_PROCESS 41 4 0.00015473996752330137 0.04374379851139481 PTPN11:APOE:APOC1:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_METABOLIC_PROCESS GWAScatalog Coronary artery disease 418 28 1.8727557794045136e-20 1.874632251956902e-17 CELSR2:PSRC1:TCF7L2:NDUFA12:FGD6:SH2B3:ATXN2:NAA25:FURIN:FES:DHX58:KAT2A:HSPB9:RAB5C:LDLR:TOMM40:APOE:APOC1:IGF2R:SLC22A3:LPA:PLG:HDAC9:TWIST1:ZC3HC1:LPL:CDKN2A:CDKN2B GWAScatalog Parental longevity (combined parental attained age, Martingale residuals) 25 12 2.0657104704759248e-20 1.874632251956902e-17 PSRC1:DCLRE1B:SH2B3:ATXN2:CHRNA3:FURIN:LDLR:APOE:APOC1:KCNK3:BCL11A:LPA GWAScatalog Body mass index (age>50) 59 13 8.048353581533251e-17 4.869253916827617e-14 TCF7L2:BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1:IGF2R:SLC22A1:SLC22A2:SLC22A3:LPA:PLG GWAScatalog Peripheral artery disease 25 10 3.4624184208299476e-16 1.571072358451589e-13 CELSR2:TCF7L2:SH2B3:ATXN2:PTPN11:CHRNA3:LDLR:LPA:HDAC9:LPL GWAScatalog Parental longevity (father's age at death) 7 7 4.787641206417303e-16 1.737913757929481e-13 SH2B3:ATXN2:CHRNA5:APOE:LPA:CDKN2A:CDKN2B GWAScatalog Red vs. brown/black hair color 18 9 8.635260513179626e-16 2.3022713183053057e-13 DPEP1:CHMP1A:CDK10:FANCA:SPIRE2:TCF25:MC1R:TUBB3:TUBB3:DEF8 GWAScatalog Coronary heart disease 70 13 8.879283321287681e-16 2.3022713183053057e-13 CELSR2:PSRC1:MYL2:SH2B3:ACAD10:ALDH2:HECTD4:LDLR:SLC22A3:LPA:ZC3HC1:CDKN2A:CDKN2B GWAScatalog Parental longevity (father's attained age) 19 9 1.6315933466290504e-15 3.7016774051646585e-13 PSRC1:ZW10:SH2B3:ATXN2:CHRNA3:FURIN:APOE:APOC1:LPA GWAScatalog Low tan response 23 9 1.4115561725520221e-14 2.8466382813132443e-12 TYR:CHMP1A:FANCA:SPIRE2:MC1R:DEF8:DBNDD1:PRDM7:IRF4 GWAScatalog Body mass index x sex x age interaction (4df test) 91 13 3.191587323911827e-14 5.5850253364514094e-12 TCF7L2:BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1:IGF2R:SLC22A1:SLC22A2:SLC22A3:LPA:PLG GWAScatalog Ischemic stroke 52 11 3.3848638402735815e-14 5.5850253364514094e-12 TCF7L2:SH2B3:ALDH2:FURIN:FES:LDLR:KCNK3:SLC22A7:ZNF318:HDAC9:TWIST1 GWAScatalog Parental longevity (combined parental age at death) 10 7 5.6511144576866496e-14 8.547310617251057e-12 SH2B3:ATXN2:CHRNA5:FURIN:APOE:APOC1:LPA GWAScatalog Myocardial infarction 55 11 6.593844105922108e-14 9.002059997071275e-12 SH2B3:ALDH2:FURIN:FES:LDLR:APOC1:LPA:PLG:ZC3HC1:CDKN2A:CDKN2B GWAScatalog Alcohol consumption (max-drinks) 17 8 6.943737738787761e-14 9.002059997071275e-12 MYL2:BRAP:ACAD10:ALDH2:NAA25:TRAFD1:HECTD4:PTPN11 GWAScatalog Parental longevity (mother's attained age) 7 6 5.271390804734593e-13 6.378382873728858e-11 SH2B3:ATXN2:CHRNA3:APOE:APOC1:LPA GWAScatalog Response to alcohol consumption (flushing response) 13 7 7.948813262336127e-13 9.016935044462545e-11 BRAP:ACAD10:ALDH2:NAA25:TRAFD1:HECTD4:PTPN11 GWAScatalog Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) 94 12 1.2917855834413214e-12 1.3791710787917638e-10 SH2B3:FURIN:FES:LDLR:APOE:APOC1:SLC22A3:LPA:PLG:HDAC9:ZC3HC1:LPL GWAScatalog Lipoprotein (a) levels 39 9 3.34863587568409e-12 3.3765411746481236e-10 APOE:IGF2R:SLC22A1:SLC22A2:SLC22A3:LPA:PLG:MAP3K4:AGPAT4 GWAScatalog Mean arterial pressure x alcohol consumption interaction (2df test) 57 10 3.826752474874478e-12 3.512410472148905e-10 SH2B3:ATXN2:BRAP:ALDH2:NAA25:HECTD4:FURIN:FES:KCNK3:SLC4A7 GWAScatalog Mean arterial pressure 131 13 3.870424762698518e-12 3.512410472148905e-10 SH2B3:ATXN2:ALDH2:NAA25:HECTD4:PTPN11:FURIN:KCNK3:SLC4A7:TTBK1:SLC22A7:CRIP3:ZNF318 GWAScatalog Systolic blood pressure x alcohol consumption interaction (2df test) 82 11 6.637942413793288e-12 5.737078800492771e-10 SH2B3:ATXN2:BRAP:ALDH2:NAA25:HECTD4:FURIN:FES:KCNK3:SLC4A7:ZNF318 GWAScatalog Alcohol dependence symptom count 19 7 2.2582870315691158e-11 1.8630868010445205e-09 BRAP:ACAD10:ALDH2:NAA25:TRAFD1:HECTD4:PTPN11 GWAScatalog Body mass index 1192 31 3.189123048965399e-11 2.5166340582053036e-09 PRAMEF1:AK5:TCF7L2:FGFR2:MYL2:SH2B3:ATXN2:BRAP:ACAD10:ALDH2:MAPKAPK5:NAA25:TRAFD1:HECTD4:RPL6:PTPN11:CPNE7:BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1:KCNK3:FOXO3:IGF2R:SLC22A1:SLC22A2:SLC22A3:LPA:PLG GWAScatalog Diastolic blood pressure x alcohol consumption interaction (2df test) 72 10 4.370548276896583e-11 3.2083001390912093e-09 SH2B3:ATXN2:BRAP:ALDH2:NAA25:HECTD4:FURIN:FES:KCNK3:SLC4A7 GWAScatalog Autism spectrum disorder or schizophrenia 474 20 4.4191461970953296e-11 3.2083001390912093e-09 TCF7L2:IREB2:HYKK:PSMA4:CHRNA5:CHRNA3:CHRNB4:FURIN:FES:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:TTBK1:SLC22A7:CRIP3:ZNF318 GWAScatalog Diastolic blood pressure 592 22 4.974503143429798e-11 3.4725858482019552e-09 TCF7L2:NOX4:SH2B3:ATXN2:ALDH2:HECTD4:RPL6:PTPN11:FURIN:FES:DPEP1:CHMP1A:KCNK3:SLC4A7:TTBK1:SLC22A7:CRIP3:ZNF318:AGPAT4:HDAC9:TWIST1:ZC3HC1 GWAScatalog Parental longevity (both parents in top 10%) 6 5 7.088254368105964e-11 4.7648821030045645e-09 CHRNA5:APOE:LPA:CDKN2A:CDKN2B GWAScatalog Medication use (beta blocking agents) 41 8 2.3893371177599276e-10 1.5488024531193817e-08 CELSR2:SH2B3:PTPN11:FES:SPATA33:KCNK3:SLC4A7:LPA GWAScatalog Stroke 68 9 6.626840151228531e-10 4.14748788775165e-08 SH2B3:FURIN:FES:LDLR:KCNK3:SLC22A7:ZNF318:HDAC9:TWIST1 GWAScatalog Coffee consumption 95 10 7.245146402498751e-10 4.383313573511744e-08 MYL2:BRAP:ACAD10:ALDH2:MAPKAPK5:NAA25:TRAFD1:HECTD4:RPL6:FES GWAScatalog Medication use (HMG CoA reductase inhibitors) 70 9 8.648503385635194e-10 5.063559240299315e-08 CELSR2:TCF7L2:LDLR:PVRL2:TOMM40:APOE:SLC22A1:LPA:LPL GWAScatalog Medication use (agents acting on the renin-angiotensin system) 131 11 1.1443180354723611e-09 6.490428857444799e-08 CELSR2:SH2B3:PTPN11:FES:CHMP1A:LDLR:APOE:KCNK3:ZNF318:LPA:HDAC9 GWAScatalog Skin pigmentation traits 9 5 1.4649404805211453e-09 7.820196976899643e-08 TYR:SPATA33:FANCA:MC1R:IRF4 GWAScatalog Alzheimer's disease in hypertension 9 5 1.4649404805211453e-09 7.820196976899643e-08 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Parental lifespan 4 4 1.8479612200343848e-09 9.582998898178309e-08 CHRNA5:CHRNA3:APOE:LPA GWAScatalog Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) 34 7 2.220173370408123e-09 1.1193374075807621e-07 ATXN2:BRAP:ALDH2:HECTD4:FURIN:FES:KCNK3 GWAScatalog Diastolic blood pressure (cigarette smoking interaction) 55 8 2.8175625890904046e-09 1.3562808531744544e-07 SH2B3:ATXN2:FURIN:FES:KCNK3:SLC4A7:SLC22A7:CRIP3 GWAScatalog Medication use (antithrombotic agents) 10 5 2.9143224944244477e-09 1.3562808531744544e-07 CELSR2:LDLR:APOE:LPA:LPL GWAScatalog Alzheimer's disease in hypertension-negative individuals 10 5 2.9143224944244477e-09 1.3562808531744544e-07 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Systolic blood pressure 738 22 3.12481010655441e-09 1.4178825858490635e-07 TCF7L2:FGFR2:NOX4:SH2B3:ALDH2:RPL6:PTPN11:FURIN:FES:DPEP1:PEPD:APOE:KCNK3:SLC4A7:TTBK1:SLC22A7:CRIP3:ZNF318:HDAC9:TWIST1:ZC3HC1:LPL GWAScatalog Systolic blood pressure (cigarette smoking interaction) 59 8 5.019033807014693e-09 2.221840575544309e-07 SH2B3:ATXN2:FURIN:FES:KCNK3:SLC4A7:SLC22A7:CRIP3 GWAScatalog Coronary artery disease or large artery stroke 22 6 5.179143258269104e-09 2.2381297651805772e-07 SH2B3:LDLR:SLC22A3:LPA:HDAC9:ZC3HC1 GWAScatalog Basal cell carcinoma 40 7 7.444653040610187e-09 3.142336109001742e-07 TYR:MC1R:CASP8:ALS2CR12:IRF4:CDKN2A:CDKN2B GWAScatalog Medication use (salicylic acid and derivatives) 5 4 9.19229868482686e-09 3.79182320749108e-07 PSRC1:LDLR:APOE:LPA GWAScatalog Hypertension 95 9 1.359735623615828e-08 5.484267015250506e-07 ALDH2:FURIN:FES:DPEP1:KCNK3:SLC4A7:SLC22A7:CRIP3:ZNF318 GWAScatalog Lipoprotein phospholipase A2 activity in cardiovascular disease 13 5 1.4648057183067193e-08 5.779613866797163e-07 CELSR2:LDLR:APOE:LPA:LPL GWAScatalog Myocardial infarction (early onset) 14 5 2.2664920307646088e-08 8.75251709752716e-07 CELSR2:PSRC1:LDLR:CDKN2A:CDKN2B GWAScatalog Lipoprotein-associated phospholipase A2 activity and mass 15 5 3.381694355989869e-08 1.2787031783586691e-06 CELSR2:PSRC1:LDLR:APOE:APOC1 GWAScatalog Esophageal cancer 16 5 4.892724945117868e-08 1.7412344657625352e-06 BRAP:ACAD10:ALDH2:HECTD4:RPL6 GWAScatalog Cerebrospinal fluid t-tau levels in mild cognitive impairment 16 5 4.892724945117868e-08 1.7412344657625352e-06 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Cerebrospinal AB1-42 levels in mild cognitive impairment 16 5 4.892724945117868e-08 1.7412344657625352e-06 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Metabolic syndrome 52 7 5.001418272704891e-08 1.7456873394152649e-06 TCF7L2:MYL2:ALDH2:HECTD4:TOMM40:APOE:LPL GWAScatalog Coronary artery disease or ischemic stroke 17 5 6.894581079498727e-08 2.3610688036396587e-06 SH2B3:LDLR:SLC22A3:LPA:ZC3HC1 GWAScatalog Lipid metabolism phenotypes 33 6 7.242513938615191e-08 2.4342894071456612e-06 CELSR2:PSRC1:LDLR:APOE:APOC1:LPL GWAScatalog Brown vs. black hair color 34 6 8.746906067426076e-08 2.886479002250605e-06 TYR:CDK10:TCF25:MC1R:DEF8:IRF4 GWAScatalog Cerebrospinal AB1-42 levels in Alzheimer's disease dementia 18 5 9.495693702871433e-08 3.0776221554842233e-06 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Breast cancer 202 11 1.0530706976780422e-07 3.353198800501134e-06 BCL2L15:AP4B1:DCLRE1B:TCF7L2:FGFR2:TOX3:CASP8:ALS2CR12:SLC4A7:CDKN2A:CDKN2B GWAScatalog Hair morphology traits 8 4 1.2671799410103058e-07 3.8776406419762e-06 SPG7:FANCA:MC1R:IRF4 GWAScatalog Emphysema distribution in smoking 8 4 1.2671799410103058e-07 3.8776406419762e-06 IREB2:HYKK:CHRNA5:CHRNA3 GWAScatalog Logical memory (immediate recall) 19 5 1.2818646750334544e-07 3.8776406419762e-06 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Body mass index x age interaction 37 6 1.4875772081261358e-07 4.42615185696547e-06 BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Inflammatory bowel disease 637 18 2.1861323078192712e-07 6.294445628148377e-06 SH2B3:ATXN2:BRAP:ACAD10:ALDH2:MAPKAPK5:NAA25:STAT5B:TM9SF4:PLAGL2:POFUT1:KIF3B:ASXL1:C20orf112:IRF4:HDAC9:CDKN2A:CDKN2B GWAScatalog Logical memory (delayed recall) 21 5 2.2195290369228434e-07 6.294445628148377e-06 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Cerebrospinal fluid p-tau levels in mild cognitive impairment 21 5 2.2195290369228434e-07 6.294445628148377e-06 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Non-melanoma skin cancer 22 5 2.857098920518839e-07 7.977899293448758e-06 TYR:MC1R:ALS2CR12:IRF4:CDKN2B GWAScatalog LDL cholesterol 178 10 3.07068555592064e-07 8.353962303362584e-06 CELSR2:PSRC1:ATXN2:BRAP:LDLR:BCAM:TOMM40:APOE:APOC1:LPA GWAScatalog Chronic obstructive pulmonary disease 136 9 3.0838318144644254e-07 8.353962303362584e-06 FGD6:IREB2:CHRNA5:CHRNA3:CHRNB4:TM9SF4:POFUT1:KIF3B:C20orf112 GWAScatalog Squamous cell carcinoma 23 5 3.631378785590272e-07 9.552105066443978e-06 TYR:SPATA33:MC1R:DEF8:IRF4 GWAScatalog Cerebrospinal fluid t-tau levels 23 5 3.631378785590272e-07 9.552105066443978e-06 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Low density lipoprotein cholesterol levels 43 6 3.7761243112081054e-07 9.790950892632444e-06 CELSR2:PSRC1:LDLR:PVRL2:APOE:APOC1 GWAScatalog Melanoma 44 6 4.348718645459635e-07 1.111679484719611e-05 TYR:CDK10:MC1R:CASP8:IRF4:CDKN2A GWAScatalog HDL cholesterol 233 11 4.422286702464361e-07 1.1147847729128909e-05 CELSR2:MYL2:ATXN2:HECTD4:PEPD:PVRL2:TOMM40:APOE:APOC1:LPA:LPL GWAScatalog C-reactive protein levels or LDL-cholesterol levels (pleiotropy) 24 5 4.562684033302833e-07 1.1344207562252935e-05 CELSR2:BRAP:HECTD4:LDLR:APOC1 GWAScatalog Vitiligo 105 8 4.892646516464404e-07 1.1941498867586576e-05 TYR:SH2B3:ATXN2:MC1R:KAT2A:HSPB9:RAB5C:IRF4 GWAScatalog Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) 72 7 4.934503664291974e-07 1.1941498867586576e-05 TM9SF4:PLAGL2:POFUT1:KIF3B:ASXL1:C20orf112:HDAC9 GWAScatalog Blond vs. brown/black hair color 145 9 5.312151868408676e-07 1.2686257422581247e-05 GRM5:TYR:RPL6:CDK10:SPATA2L:TCF25:MC1R:DBNDD1:IRF4 GWAScatalog Tanning 11 4 5.882254417648939e-07 1.3865313984458213e-05 GRM5:TYR:MC1R:IRF4 GWAScatalog Metabolite levels (lipoprotein measures) 26 5 6.986628331183643e-07 1.6257346693715786e-05 CELSR2:LDLR:APOE:LPA:LPL GWAScatalog Mental health study participation (completed survey) 27 5 8.529050826916245e-07 1.9427501947134924e-05 TCF7L2:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Medication use (diuretics) 78 7 8.563086257690326e-07 1.9427501947134924e-05 SH2B3:PTPN11:FES:CHMP1A:KCNK3:SLC4A7:ZNF318 GWAScatalog Ischemic stroke (large artery atherosclerosis) 12 4 8.778070143310796e-07 1.9669379395196413e-05 SH2B3:LPA:HDAC9:TWIST1 GWAScatalog Cholesterol, total 118 8 1.1946384932604518e-06 2.6442303234972192e-05 CELSR2:PSRC1:BRAP:LDLR:TOMM40:APOE:APOC1:LPA GWAScatalog Pulse pressure 647 17 1.333442551513737e-06 2.9104345551784148e-05 TCF7L2:NOX4:FGD6:FES:APOE:KCNK3:SLC4A7:TTBK1:SLC22A7:CRIP3:ZNF318:FOXO3:SLC22A3:HDAC9:TWIST1:LPL:CDKN2B GWAScatalog Alzheimer's disease or HDL levels (pleiotropy) 53 6 1.3469779759503407e-06 2.9104345551784148e-05 BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) 128 8 2.2092947735367933e-06 4.717494134081506e-05 CELSR2:SH2B3:LDLR:PEPD:BCL3:LPA:PLG:LPL GWAScatalog Alopecia areata 90 7 2.2674472464168064e-06 4.7853683165657024e-05 MAGI3:BCL2L15:AP4B1:DCLRE1B:SH2B3:ATXN2:IRF4 GWAScatalog Alzheimer's disease (age of onset) 15 4 2.3835309337422266e-06 4.916032550843342e-05 PVRL2:TOMM40:APOE:APOC1 GWAScatalog Esophageal squamous cell carcinoma 15 4 2.3835309337422266e-06 4.916032550843342e-05 CASP8:ALS2CR12:CDKN2A:CDKN2B GWAScatalog Hypothyroidism 60 6 2.8281222042910187e-06 5.71209677011808e-05 SH2B3:ATXN2:BRAP:NAA25:HECTD4:PTPN11 GWAScatalog Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) 34 5 2.832444679397395e-06 5.71209677011808e-05 SH2B3:BRAP:FES:KCNK3:SLC4A7 GWAScatalog Alzheimer's disease 63 6 3.7764349761889796e-06 7.532120309651646e-05 BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Estimated glomerular filtration rate 483 14 4.028548496318738e-06 7.942283082738146e-05 AK5:ATXN2:ACAD10:ALDH2:NAA25:DPEP1:CHMP1A:RP11-368I7.4:SPATA2L:HTT:CRIP3:FOXO3:SLC22A2:SLC22A3 GWAScatalog Cerebrospinal fluid p-tau levels 17 4 4.113358731555844e-06 7.942283082738146e-05 BCAM:PVRL2:APOE:APOC1 GWAScatalog Abdominal aortic aneurysm 17 4 4.113358731555844e-06 7.942283082738146e-05 CELSR2:PSRC1:LDLR:CDKN2A GWAScatalog Plateletcrit 190 9 5.007840407279083e-06 9.567610883380564e-05 SH2B3:ATXN2:BRAP:NAA25:APOC1:ALS2CR12:HDAC9:ZC3HC1:CDKN2A GWAScatalog Alcohol consumption (drinkers vs non-drinkers) 6 3 5.6218056179068035e-06 0.00010628726246355051 MYL2:ALDH2:HECTD4 GWAScatalog Reaction time 39 5 5.707279118029512e-06 0.0001067908412291089 SH2B3:ATXN2:HECTD4:PTPN11:FOXO3 GWAScatalog Type 2 diabetes 438 13 7.0523499031465414e-06 0.0001306123987164385 ADAM30:NOTCH2:TCF7L2:FGFR2:PEPD:TOMM40:APOE:APOC1:BCL11A:SLC22A3:LPL:CDKN2A:CDKN2B GWAScatalog Diffusing capacity of carbon monoxide 73 6 8.9631626015007e-06 0.00016432464769417952 IREB2:PSMA4:CHRNA5:CHRNA3:CHRNB4:LPL GWAScatalog High density lipoprotein cholesterol levels 74 6 9.7014213483745e-06 0.00017593630840442967 FGFR2:MYL2:HECTD4:APOE:APOC1:LPL GWAScatalog Facial pigmentation 7 3 9.790395123331899e-06 0.00017593630840442967 SPATA33:MC1R:IRF4 GWAScatalog Cardiovascular disease risk factors 21 4 1.013331367190253e-05 0.0001768458107163759 CELSR2:LDLR:TOMM40:LPL GWAScatalog Skin pigmentation 21 4 1.013331367190253e-05 0.0001768458107163759 GRM5:TYR:MC1R:IRF4 GWAScatalog Alzheimer's disease biomarkers 21 4 1.013331367190253e-05 0.0001768458107163759 PVRL2:TOMM40:APOE:APOC1 GWAScatalog Medication use (calcium channel blockers) 77 6 1.2216601984978067e-05 0.00021117269145462086 SH2B3:FES:CHMP1A:APOE:KCNK3:ZNF318 GWAScatalog HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) 118 7 1.372521536414982e-05 0.0002350119423201125 CELSR2:SH2B3:PEPD:BCL3:LPA:PLG:LPL GWAScatalog Hippocampal volume 47 5 1.4573658095513755e-05 0.0002472073779753034 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog Alzheimer's disease or family history of Alzheimer's disease 48 5 1.6182249376681687e-05 0.00027195169091367836 BCL3:BCAM:PVRL2:TOMM40:APOE GWAScatalog Lipid traits 24 4 1.7715853269531514e-05 0.0002949933365522908 TOMM40:APOE:APOC1:LPL GWAScatalog Post bronchodilator FEV1/FVC ratio in COPD 49 5 1.792586386315629e-05 0.00029577675374207877 IREB2:HYKK:CHRNA5:CHRNA3:CHRNB4 GWAScatalog Cerebrospinal fluid AB1-42 levels 50 5 1.9812334659489885e-05 0.00032395844510787515 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) 84 6 2.0166899348812703e-05 0.000326811806411563 CELSR2:SH2B3:LDLR:BCL3:LPA:PLG GWAScatalog Local histogram emphysema pattern 9 3 2.3269441882912182e-05 0.0003672524958042227 HYKK:CHRNA5:CHRNA3 GWAScatalog Skin, hair and eye pigmentation (multivariate analysis) 9 3 2.3269441882912182e-05 0.0003672524958042227 GRM5:TYR:IRF4 GWAScatalog Cerebrospinal fluid p-Tau181p:AB1-42 ratio 9 3 2.3269441882912182e-05 0.0003672524958042227 TOMM40:APOE:APOC1 GWAScatalog Hippocampal volume in Alzheimer's disease dementia 52 5 2.4046420590592776e-05 0.00037624356355108526 BCAM:PVRL2:TOMM40:APOE:APOC1 GWAScatalog LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) 87 6 2.465097995871138e-05 0.00038240622756462525 CELSR2:SH2B3:LDLR:BCL3:LPA:PLG GWAScatalog Blood pressure 90 6 2.990476287140133e-05 0.0004599758017931646 ATXN2:ALDH2:RPL6:PTPN11:FES:SLC4A7 GWAScatalog Platelet count 304 10 3.579693206130082e-05 0.0005459784175736218 SH2B3:ATXN2:BRAP:ACAD10:NAA25:PTPN11:APOE:HDAC9:ZC3HC1:CDKN2A GWAScatalog LDL cholesterol levels 95 6 4.063205886952514e-05 0.0006145598904015677 CELSR2:LDLR:BCL3:TOMM40:APOE:APOC1 GWAScatalog Crohn's disease 597 14 4.295330105541099e-05 0.0006442995158311649 MAGI3:BCL2L15:AP4B1:DCLRE1B:ADAM30:SH2B3:ATXN2:BRAP:ACAD10:ALDH2:MAPKAPK5:NAA25:STAT5B:IRF4 GWAScatalog Beta-2 microglubulin plasma levels 2 2 4.3673935753809265e-05 0.0006444568568549905 SH2B3:ATXN2 GWAScatalog Coronary heart disease (SNP X SNP interaction) 2 2 4.3673935753809265e-05 0.0006444568568549905 CDKN2A:CDKN2B GWAScatalog Chronic bronchitis and chronic obstructive pulmonary disease 11 3 4.526552435469183e-05 0.0006625558605142392 IREB2:HYKK:CHRNA3 GWAScatalog HDL cholesterol levels 143 7 4.745578266469977e-05 0.0006890579642914407 CELSR2:MYL2:HECTD4:PEPD:APOE:APOC1:LPL GWAScatalog Cerebrospinal T-tau levels 32 4 5.754081162805183e-05 0.0008288616913088418 PVRL2:TOMM40:APOE:APOC1 GWAScatalog Freckles 12 3 6.0061430134930284e-05 0.0008583582338180982 TYR:MC1R:IRF4 GWAScatalog Endometrial cancer (endometrioid histology) 33 4 6.514247229357115e-05 0.0009236999001002472 SH2B3:BCL11A:CDKN2A:CDKN2B GWAScatalog LDL cholesterol levels in current drinkers 64 5 6.620145802910391e-05 0.0009314391187815783 CELSR2:LDLR:BCL3:LPA:PLG GWAScatalog Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) 34 4 7.345047597760429e-05 0.001025481645379629 SH2B3:FURIN:KCNK3:SLC4A7 GWAScatalog Homocysteine levels 13 3 7.770142921065659e-05 0.0010683946516465283 NOX4:DPEP1:FANCA GWAScatalog Cutaneous squamous cell carcinoma 13 3 7.770142921065659e-05 0.0010683946516465283 TYR:MC1R:IRF4 GWAScatalog Lung cancer in ever smokers 107 6 7.91935618039383e-05 0.0010807241704823161 AK5:CHRNA5:CHRNA3:CHRNB4:IRF4:HIST1H4H GWAScatalog Chronic lymphocytic leukemia 69 5 9.50337855599152e-05 0.0012872113491884036 TMPRSS5:DPEP1:CASP8:IRF4:CDKN2B GWAScatalog Cerebral amyloid deposition (PET imaging) 37 4 0.00010300583947458798 0.0013848562862694607 PVRL2:TOMM40:APOE:APOC1 GWAScatalog Metabolite levels 114 6 0.00011253609245210354 0.0014908978671574302 CELSR2:PSRC1:HECTD4:LDLR:APOE:LPL GWAScatalog Serum uric acid levels 114 6 0.00011253609245210354 0.0014908978671574302 BRAP:ACAD10:ALDH2:HECTD4:DPEP1:ZNF318 GWAScatalog Post bronchodilator FEV1 in COPD 38 4 0.0001145356966948302 0.0014955560395763798 IREB2:HYKK:CHRNA5:CHRNA3 GWAScatalog Endometrial cancer 38 4 0.0001145356966948302 0.0014955560395763798 SH2B3:BCL11A:CDKN2A:CDKN2B GWAScatalog Cancer (pleiotropy) 15 3 0.000122421070372184 0.001587101733753671 FGFR2:SH2B3:CDKN2B GWAScatalog Post bronchodilator FEV1 117 6 0.00012985815948144864 0.001671578435878222 IREB2:HYKK:PSMA4:CHRNA5:CHRNA3:CHRNB4 GWAScatalog Triglycerides 174 7 0.00016253239040989886 0.002077438652070186 ALDH2:PEPD:TOMM40:APOE:APOC1:LPA:LPL GWAScatalog Pulse pressure x alcohol consumption interaction (2df test) 42 4 0.00017015478370349798 0.0021446592529295056 FES:KCNK3:SLC4A7:ZNF318 GWAScatalog Cerebrospinal P-tau181p levels 42 4 0.00017015478370349798 0.0021446592529295056 PVRL2:TOMM40:APOE:APOC1 GWAScatalog Retinal vascular caliber 18 3 0.000216377563386194 0.0027084501899720145 SH2B3:ATXN2:PTPN11 GWAScatalog Breast cancer in BRCA2 mutation carriers 4 2 0.00025976734358176037 0.0032292995109650348 FGFR2:TOX3 GWAScatalog Post bronchodilator FEV1/FVC ratio 196 7 0.00033636797518936656 0.0041531147957054445 TCF7L2:IREB2:HYKK:PSMA4:CHRNA5:CHRNA3:CHRNB4 GWAScatalog Lymphocyte counts 141 6 0.00035753215115680407 0.004384600367227023 SH2B3:ANKRD11:CASP8:IRF4:HDAC9:CDKN2A GWAScatalog Alcohol consumption 22 3 0.00040051714622918997 0.004878782687288454 MYL2:ALDH2:HECTD4 GWAScatalog Hair color 53 4 0.0004207931251605209 0.005080379374568788 GRM5:TYR:MC1R:IRF4 GWAScatalog Lung adenocarcinoma 95 5 0.00042710703504991135 0.005080379374568788 AK5:CHRNA5:CHRNA3:CHRNB4:IRF4 GWAScatalog Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) 5 2 0.00043106249238765475 0.005080379374568788 CDKN2A:CDKN2B GWAScatalog Posterior cortical atrophy and Alzheimer's disease 5 2 0.00043106249238765475 0.005080379374568788 TOMM40:APOE GWAScatalog Thyroid peroxidase antibody positivity 5 2 0.00043106249238765475 0.005080379374568788 SH2B3:ATXN2 GWAScatalog High light scatter reticulocyte percentage of red cells 147 6 0.00044650904250886724 0.005228476852603832 ATXN2:TCF25:APOE:BCL11A:C20orf112:FOXO3 GWAScatalog Age-related macular degeneration 54 4 0.0004521404033373022 0.005260479692674382 TYR:PVRL2:TOMM40:APOE GWAScatalog Nicotine dependence 23 3 0.00045836882980010684 0.005265439405615152 CHRNA5:CHRNA3:CHRNB4 GWAScatalog Body fat percentage 23 3 0.00045836882980010684 0.005265439405615152 TOMM40:APOE:APOC1 GWAScatalog High light scatter reticulocyte count 149 6 0.0004797176952139943 0.0054760227472540855 ATXN2:TCF25:APOE:BCL11A:C20orf112:FOXO3 GWAScatalog Quantitative traits 25 3 0.0005895470294919501 0.006646135767253971 TOMM40:APOE:APOC1 GWAScatalog Nevus count or cutaneous melanoma 25 3 0.0005895470294919501 0.006646135767253971 TYR:MC1R:CASP8 GWAScatalog Lung cancer 157 6 0.0006322440373555905 0.006955153850871632 AK5:PSMA4:CHRNA5:CHRNA3:CHRNB4:HIST1H4H GWAScatalog Progranulin levels 6 2 0.0006437828357831593 0.006955153850871632 CELSR2:PSRC1 GWAScatalog Metabolic syndrome (multivariate analysis) 6 2 0.0006437828357831593 0.006955153850871632 MYL2:LPL GWAScatalog Thyroid peroxidase antibody levels 6 2 0.0006437828357831593 0.006955153850871632 SH2B3:ATXN2 GWAScatalog Type 1 diabetes and autoimmune thyroid diseases 6 2 0.0006437828357831593 0.006955153850871632 MAGI3:BCL2L15 GWAScatalog Brain imaging 6 2 0.0006437828357831593 0.006955153850871632 TOMM40:APOE GWAScatalog Black vs. red hair color 6 2 0.0006437828357831593 0.006955153850871632 MC1R:IRF4 GWAScatalog Verbal declarative memory 60 4 0.0006761306534419973 0.007261403171581213 PVRL2:TOMM40:APOE:APOC1 GWAScatalog HDL cholesterol levels in current drinkers 106 5 0.0007049792456128821 0.007526690181102242 CELSR2:SH2B3:PEPD:BCL3:LPL GWAScatalog Body fat distribution (leg fat ratio) 223 7 0.0007262232408398104 0.0077081589597909695 HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H GWAScatalog Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) 165 6 0.000819971978180647 0.00865261128138299 TCF7L2:CHRNA3:FURIN:BCL11A:MSANTD1:FOXO3 GWAScatalog Brown vs. non-brown hair color 7 2 0.0008973798120865512 0.009048579771872725 MC1R:IRF4 GWAScatalog Glycemic traits 7 2 0.0008973798120865512 0.009048579771872725 MYL2:HECTD4 GWAScatalog Longevity (age >90th survival percentile) 7 2 0.0008973798120865512 0.009048579771872725 APOE:GPR78 GWAScatalog Skin sensitivity to sun 7 2 0.0008973798120865512 0.009048579771872725 TYR:MC1R GWAScatalog Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease 7 2 0.0008973798120865512 0.009048579771872725 CHRNA5:CHRNA3 GWAScatalog Gamma glutamyl transpeptidase 7 2 0.0008973798120865512 0.009048579771872725 MYL2:HECTD4 GWAScatalog Light vs. dark hair color 7 2 0.0008973798120865512 0.009048579771872725 MC1R:IRF4 GWAScatalog Stroke (ischemic) 7 2 0.0008973798120865512 0.009048579771872725 ALDH2:HDAC9 GWAScatalog C-reactive protein 29 3 0.0009186600326653046 0.009161362413667735 TOMM40:APOE:APOC1 GWAScatalog Carotid intima media thickness 29 3 0.0009186600326653046 0.009161362413667735 LDLR:APOE:APOC1 GWAScatalog Body fat distribution (trunk fat ratio) 236 7 0.0010113918527209023 0.010031017555674523 HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H GWAScatalog Rosacea symptom severity 115 5 0.0010182905402654535 0.010044550709683684 FANCA:TCF25:TUBB3:TUBB3:PRDM7:IRF4 GWAScatalog Total cholesterol levels 177 6 0.001179020034789221 0.011380147585979964 CELSR2:ATXN2:LDLR:APOE:APOC1:LPA GWAScatalog Vigorous physical activity 8 2 0.0011913102156122276 0.011380147585979964 APOE:FOXO3 GWAScatalog Skin colour saturation 8 2 0.0011913102156122276 0.011380147585979964 MC1R:IRF4 GWAScatalog Obsessive-compulsive disorder or autism spectrum disorder 8 2 0.0011913102156122276 0.011380147585979964 MC1R:TUBB3:TUBB3 GWAScatalog Current cigarettes per day in chronic obstructive pulmonary disease 8 2 0.0011913102156122276 0.011380147585979964 IREB2:CHRNA3 GWAScatalog Eye color (brightness) 8 2 0.0011913102156122276 0.011380147585979964 TYR:IRF4 GWAScatalog Emphysema imaging phenotypes 32 3 0.0012290548062960619 0.011679238080771478 HYKK:CHRNA5:CHRNA3 GWAScatalog Primary sclerosing cholangitis 33 3 0.001345446039742549 0.012718669594441285 SH2B3:ATXN2:HDAC9 GWAScatalog Age at first sexual intercourse 34 3 0.0014685423845779996 0.013810385637352691 FURIN:CPNE7:KIF3B GWAScatalog Cerebrospinal fluid t-tau:AB1-42 ratio 35 3 0.0015984834995348852 0.014954884286885652 TOMM40:APOE:APOC1 GWAScatalog Monobrow 77 4 0.001720700678516859 0.016015752469272303 TCF25:HTT:IRF4:HDAC9 GWAScatalog Hematological and biochemical traits 36 3 0.0017354054375705397 0.01607020851627821 BRAP:ALDH2:LPL GWAScatalog Type 2 diabetes (age of onset) 37 3 0.0018794406962326696 0.017228206382132807 AK5:HDAC9:TWIST1 GWAScatalog Automobile speeding propensity 37 3 0.0018794406962326696 0.017228206382132807 TCF7L2:MSANTD1:TTBK1 GWAScatalog Urate levels 80 4 0.0019805468596690566 0.017973462751496687 ATXN2:PTPN11:SLC22A7:HDAC9 GWAScatalog Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) 80 4 0.0019805468596690566 0.017973462751496687 PEPD:LPA:PLG:LPL GWAScatalog Colorectal cancer 134 5 0.0020047915499786773 0.018102968473688055 TCF7L2:SH2B3:BRAP:ACAD10:SLC22A3 GWAScatalog Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) 82 4 0.0021681232324047214 0.019480909241656283 PEPD:LPA:PLG:LPL GWAScatalog Endometriosis 39 3 0.0021893636873636575 0.01957485267273418 VEZT:CDKN2A:CDKN2B GWAScatalog Alzheimer's disease (late onset) 83 4 0.0022663567141213794 0.020163909000638743 BCL3:PVRL2:TOMM40:APOE GWAScatalog Alanine aminotransferase levels 11 2 0.0023097493122209755 0.02025214976657522 TRAFD1:HECTD4 GWAScatalog Smoking behaviour (cigarettes smoked per day) 11 2 0.0023097493122209755 0.02025214976657522 CHRNA3:GRK4 GWAScatalog Eye color 11 2 0.0023097493122209755 0.02025214976657522 TYR:IRF4 GWAScatalog Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) 85 4 0.0024719483335903297 0.021466919739073914 SH2B3:ATXN2:PTPN11:SLC4A7 GWAScatalog Type 1 diabetes 85 4 0.0024719483335903297 0.021466919739073914 SH2B3:NAA25:TRAFD1:PTPN11 GWAScatalog Offspring birth weight 141 5 0.002502372996456261 0.021627652326514826 TCF7L2:SH2B3:FURIN:FES:HIST1H2BH GWAScatalog Schizophrenia 704 12 0.0025313351315526546 0.02177428087093871 TCF7L2:IREB2:HYKK:PSMA4:CHRNA5:CHRNA3:CHRNB4:FURIN:FES:MAN2A2:PEPD:FOXO3 GWAScatalog Waist circumference 143 5 0.0026596660130619293 0.022770253838242462 PRMT6:TCF7L2:TOMM40:FOXO3:SLC22A2 GWAScatalog Systolic blood pressure x smoking status (ever vs never) interaction (2df test) 87 4 0.002690015718555085 0.022921964925715865 SH2B3:ATXN2:PTPN11:SLC4A7 GWAScatalog Cognitive decline (age-related) 43 3 0.002900016299466112 0.0245959326333224 TCF7L2:TOMM40:APOE GWAScatalog Aspartate aminotransferase levels 44 3 0.003097266397720091 0.026025641258620207 ALDH2:TRAFD1:HECTD4 GWAScatalog Primary biliary cirrhosis 44 3 0.003097266397720091 0.026025641258620207 SH2B3:ATXN2:BRAP GWAScatalog Skin aging (microtopography measurement) 13 2 0.003247320608466438 0.026669171512970973 MC1R:IRF4 GWAScatalog Nasopharyngeal carcinoma 13 2 0.003247320608466438 0.026669171512970973 CDKN2A:CDKN2B GWAScatalog Sarcoidosis 13 2 0.003247320608466438 0.026669171512970973 SH2B3:ATXN2 GWAScatalog vWF and FVIII levels 13 2 0.003247320608466438 0.026669171512970973 KAT2A:RAB5C GWAScatalog Aging 13 2 0.003247320608466438 0.026669171512970973 PLG:MAP3K4 GWAScatalog Primary biliary cholangitis 93 4 0.003422734077815646 0.027983163744303593 SH2B3:ATXN2:ALDH2:TRAFD1 GWAScatalog Asthma (age of onset) 46 3 0.0035160227625023657 0.028616956564761407 SH2B3:ATXN2:BRAP GWAScatalog BRCA1/2-negative high-risk breast cancer 14 2 0.0037721384493879565 0.030564425382317593 FGFR2:TOX3 GWAScatalog Prostate cancer 302 7 0.004052851125378452 0.03269299907805285 TCF7L2:HTR3B:CASP8:FOXO3:SLC22A1:SLC22A2:SLC22A3 GWAScatalog Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) 98 4 0.004128633250524354 0.03315694402522878 SH2B3:ATXN2:PTPN11:SLC4A7 GWAScatalog Medication use (thyroid preparations) 99 4 0.004280734264244146 0.03422701625375826 SH2B3:PTPN11:RAB5C:IRF4 GWAScatalog Glioblastoma 15 2 0.0043336334306583995 0.034498002967741206 CDKN2A:CDKN2B GWAScatalog Fasting blood glucose 51 3 0.004708986135631641 0.037322313695071746 TCF7L2:HDAC9:CDKN2B GWAScatalog Immature fraction of reticulocytes 102 4 0.0047596452170498545 0.03755980899541515 ATXN2:APOE:BCL11A:C20orf112 GWAScatalog Response to statins (LDL cholesterol change) 16 2 0.004931303569852247 0.0385789481865596 APOE:LPA GWAScatalog Iron status biomarkers (ferritin levels) 16 2 0.004931303569852247 0.0385789481865596 HIST1H2BH:HIST1H3G GWAScatalog Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) 104 4 0.00509817500124075 0.039713251619107125 SH2B3:ATXN2:PTPN11:SLC4A7 GWAScatalog Asthma (childhood onset) 241 6 0.005460477694252649 0.04235370519260068 SH2B3:ATXN2:BRAP:GHDC:STAT5B:IRF4 GWAScatalog Iron status biomarkers (iron levels) 17 2 0.005564651839674894 0.04297805569791461 HIST1H2BH:HIST1H3G GWAScatalog Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) 18 2 0.006233186124182524 0.04793742718386136 AP4B1:PTPN11 Chemical_and_Genetic_pertubation NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON 52 21 5.182045521645092e-33 1.7111114312472095e-29 ANKRD11:SPG7:CPNE7:DPEP1:CHMP1A:SPATA33:CDK10:SPATA2L:VPS9D1:ZNF276:FANCA:SPIRE2:TCF25:MC1R:TUBB3:TUBB3:DEF8:CENPBD1:DBNDD1:GAS8:C16orf3:PRDM7 http://www.gsea-msigdb.org/gsea/msigdb/cards/NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON Chemical_and_Genetic_pertubation ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP 60 9 2.0784017213670566e-10 3.4314412419770106e-07 ZNF276:FANCA:SPIRE2:TCF25:MC1R:DEF8:DBNDD1:GAS8:PRDM7 http://www.gsea-msigdb.org/gsea/msigdb/cards/ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP Chemical_and_Genetic_pertubation GRATIAS_RETINOBLASTOMA_16Q24 18 4 5.2614735297019645e-06 0.005791128531691962 ANKRD11:SPG7:CHMP1A:TCF25 http://www.gsea-msigdb.org/gsea/msigdb/cards/GRATIAS_RETINOBLASTOMA_16Q24 Chemical_and_Genetic_pertubation ROVERSI_GLIOMA_COPY_NUMBER_UP 97 6 4.5702387351633e-05 0.03772732075877304 BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1 http://www.gsea-msigdb.org/gsea/msigdb/cards/ROVERSI_GLIOMA_COPY_NUMBER_UP GO_cc GO_DNA_PACKAGING_COMPLEX 110 8 6.993382162933989e-07 0.0007000375545096923 IRF4:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_DNA_PACKAGING_COMPLEX GO_cc GO_PROTEIN_LIPID_COMPLEX 39 5 5.707279118029512e-06 0.0021508781052601545 LDLR:APOE:APOC1:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX GO_cc GO_PROTEIN_DNA_COMPLEX 196 9 6.44618812765281e-06 0.0021508781052601545 TCF7L2:IRF4:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX GO_cc GO_CHYLOMICRON 13 3 7.770142921065659e-05 0.01944478265996681 APOE:APOC1:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CHYLOMICRON GO_cc GO_NUCLEAR_NUCLEOSOME 38 4 0.0001145356966948302 0.022930046478305006 IRF4:HIST1H4F:HIST1H3G:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_NUCLEAR_NUCLEOSOME GO_cc GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX 17 3 0.00018119154840443372 0.030228789992139692 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX GO_cc GO_TRIGLYCERIDE_RICH_PLASMA_LIPOPROTEIN_PARTICLE 19 3 0.0002557051658745902 0.03583455454165274 APOE:APOC1:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_PLASMA_LIPOPROTEIN_PARTICLE GO_cc GO_CHROMATIN 547 12 0.000286390046286935 0.03583455454165274 TCF7L2:KAT2A:ASXL1:IRF4:HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/GO_CHROMATIN Positional_gene_sets chr16q24 78 22 1.860509538806763e-30 5.562923521032221e-28 ANKRD11:SPG7:CPNE7:DPEP1:CHMP1A:SPATA33:CDK10:RP11-368I7.4:SPATA2L:VPS9D1:ZNF276:FANCA:SPIRE2:TCF25:MC1R:TUBB3:TUBB3:DEF8:CENPBD1:DBNDD1:GAS8:C16orf3:PRDM7 http://www.gsea-msigdb.org/gsea/msigdb/cards/chr16q24 Positional_gene_sets chr12q24 213 12 1.8502083949209105e-08 2.766061550406761e-06 MYL2:SH2B3:ATXN2:BRAP:ACAD10:ALDH2:MAPKAPK5:NAA25:TRAFD1:HECTD4:RPL6:PTPN11 http://www.gsea-msigdb.org/gsea/msigdb/cards/chr12q24 Positional_gene_sets chr6q26 7 4 6.368627751811455e-08 6.347398992638749e-06 LPA:PLG:MAP3K4:AGPAT4 http://www.gsea-msigdb.org/gsea/msigdb/cards/chr6q26 Positional_gene_sets chr12q22 19 4 6.630350079885297e-06 0.000495618668471426 NDUFA12:NR2C1:FGD6:VEZT http://www.gsea-msigdb.org/gsea/msigdb/cards/chr12q22 Positional_gene_sets chr15q25 73 6 8.9631626015007e-06 0.0005359971235697419 IREB2:HYKK:PSMA4:CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/chr15q25 Positional_gene_sets chr1p13 115 7 1.1594921398331171e-05 0.0005778135830168367 PRMT6:CELSR2:PSRC1:MAGI3:BCL2L15:AP4B1:DCLRE1B http://www.gsea-msigdb.org/gsea/msigdb/cards/chr1p13 Positional_gene_sets chr6p22 147 7 5.655258114774422e-05 0.0024156031090250747 HIST1H1D:HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/chr6p22 Positional_gene_sets chr20q11 124 6 0.00017854532288819137 0.0066731314429461525 TM9SF4:PLAGL2:POFUT1:KIF3B:ASXL1:C20orf112 http://www.gsea-msigdb.org/gsea/msigdb/cards/chr20q11 Positional_gene_sets chr6q25 68 4 0.0010840474078820334 0.03601446388408089 IGF2R:SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/chr6q25 Positional_gene_sets chr11q23 122 5 0.0013256538107981294 0.03963704894286407 TMPRSS5:ZW10:CLDN25:USP28:HTR3B http://www.gsea-msigdb.org/gsea/msigdb/cards/chr11q23 Wikipathways Composition of Lipid Particles 9 3 2.3269441882912182e-05 0.010478364820312312 LDLR:APOE:LPL http://www.wikipathways.org/instance/WP3601_r106212 Wikipathways Statin Pathway 29 4 3.859434556284461e-05 0.010478364820312312 LDLR:APOE:APOC1:LPL http://www.wikipathways.org/instance/WP430_r106797 Wikipathways Metabolic pathway of LDL, HDL and TG, including diseases 16 3 0.00014994245610995864 0.027139584555902513 LDLR:APOE:LPL http://www.wikipathways.org/instance/WP4522_r104036 Wikipathways Nicotine Activity on Chromaffin Cells 4 2 0.00025976734358176037 0.03526341689122397 CHRNA3:CHRNB4 http://www.wikipathways.org/instance/WP1603_r106160 Wikipathways Nicotine Activity on Dopaminergic Neurons 21 3 0.00034758139948784766 0.037747339984380256 CHRNA5:CHRNA3:KCNK3 http://www.wikipathways.org/instance/WP1602_r106663 Curated_gene_sets NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON 52 21 5.182045521645092e-33 2.850643241456965e-29 ANKRD11:SPG7:CPNE7:DPEP1:CHMP1A:SPATA33:CDK10:SPATA2L:VPS9D1:ZNF276:FANCA:SPIRE2:TCF25:MC1R:TUBB3:TUBB3:DEF8:CENPBD1:DBNDD1:GAS8:C16orf3:PRDM7 http://www.gsea-msigdb.org/gsea/msigdb/cards/NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON Curated_gene_sets ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP 60 9 2.0784017213670566e-10 5.716643934620089e-07 ZNF276:FANCA:SPIRE2:TCF25:MC1R:DEF8:DBNDD1:GAS8:PRDM7 http://www.gsea-msigdb.org/gsea/msigdb/cards/ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP Curated_gene_sets REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 104 9 3.024262643678749e-08 5.545489600958932e-05 NOTCH2:FURIN:KAT2A:POFUT1:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Curated_gene_sets REACTOME_SIGNALING_BY_NOTCH 228 11 3.562974878335424e-07 0.0004899981201430792 NOTCH2:PSMA4:FURIN:KAT2A:POFUT1:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:HDAC9 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_NOTCH Curated_gene_sets REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE 120 8 1.3571344745855617e-06 0.001493119348939035 MAPKAPK5:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE Curated_gene_sets REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT 15 4 2.3835309337422266e-06 0.002185300611085998 SLC22A7:SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Curated_gene_sets REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT 5 3 2.8246203743858396e-06 0.002219748097070929 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT Curated_gene_sets REACTOME_CELLULAR_SENESCENCE 189 9 4.797185377175365e-06 0.003215929542987834 MAPKAPK5:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_SENESCENCE Curated_gene_sets GRATIAS_RETINOBLASTOMA_16Q24 18 4 5.2614735297019645e-06 0.003215929542987834 ANKRD11:SPG7:CHMP1A:TCF25 http://www.gsea-msigdb.org/gsea/msigdb/cards/GRATIAS_RETINOBLASTOMA_16Q24 Curated_gene_sets REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP 105 7 6.362469433740618e-06 0.003499994435500714 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP Curated_gene_sets REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE 71 6 7.622942349595333e-06 0.003812164169556721 FURIN:LDLR:APOE:APOC1:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE Curated_gene_sets REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS 9 3 2.3269441882912182e-05 0.010667099983158325 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS Curated_gene_sets REACTOME_FORMATION_OF_THE_BETA_CATENIN:TCF_TRANSACTIVATING_COMPLEX 88 6 2.6312183685548415e-05 0.010704559787629119 TCF7L2:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_FORMATION_OF_THE_BETA_CATENIN:TCF_TRANSACTIVATING_COMPLEX Curated_gene_sets REACTOME_CELLULAR_RESPONSES_TO_STRESS 429 12 2.8981831761141522e-05 0.010704559787629119 NOX4:MAPKAPK5:PSMA4:TUBB3:TUBB3:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_RESPONSES_TO_STRESS Curated_gene_sets REACTOME_NEUROTRANSMITTER_CLEARANCE 10 3 3.3080806469677336e-05 0.010704559787629119 ALDH2:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEUROTRANSMITTER_CLEARANCE Curated_gene_sets REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM 10 3 3.3080806469677336e-05 0.010704559787629119 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Curated_gene_sets REACTOME_ORGANIC_CATION_TRANSPORT 10 3 3.3080806469677336e-05 0.010704559787629119 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ORGANIC_CATION_TRANSPORT Curated_gene_sets REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION 93 6 3.602299518645112e-05 0.010826944499060734 PRMT6:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION Curated_gene_sets REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 1194 21 3.739537274716487e-05 0.010826944499060734 PRMT6:NOTCH2:TCF7L2:NR2C1:MAPKAPK5:PTPN11:PSMA4:PRDM7:KAT2A:APOE:HTT:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:FOXO3:HDAC9:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Curated_gene_sets REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 11 3 4.526552435469183e-05 0.011427674219151505 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Curated_gene_sets REACTOME_CELLULAR_RESPONSES_TO_EXTERNAL_STIMULI 523 13 4.5318811073107746e-05 0.011427674219151505 NOX4:MAPKAPK5:PSMA4:TUBB3:TUBB3:TOMM40:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_RESPONSES_TO_EXTERNAL_STIMULI Curated_gene_sets ROVERSI_GLIOMA_COPY_NUMBER_UP 97 6 4.5702387351633e-05 0.011427674219151505 BCL3:BCAM:PVRL2:TOMM40:APOE:APOC1 http://www.gsea-msigdb.org/gsea/msigdb/cards/ROVERSI_GLIOMA_COPY_NUMBER_UP Curated_gene_sets REACTOME_DNA_METHYLATION 60 5 4.8435350539933506e-05 0.011584472318268445 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DNA_METHYLATION Curated_gene_sets REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION 100 6 5.424621659810529e-05 0.012433684896090716 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION Curated_gene_sets REACTOME_PLASMA_LIPOPROTEIN_REMODELING 32 4 5.754081162805183e-05 0.012661280190636524 FURIN:APOE:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_REMODELING Curated_gene_sets REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 63 5 6.135326662294666e-05 0.012980935372801138 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 Curated_gene_sets REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION 64 5 6.620145802910391e-05 0.013276363324902396 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION Curated_gene_sets REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION 104 6 6.757647211366426e-05 0.013276363324902396 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION Curated_gene_sets REACTOME_AMYLOID_FIBER_FORMATION 105 6 7.128641166811531e-05 0.01352229484780353 FURIN:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_AMYLOID_FIBER_FORMATION Curated_gene_sets REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA 69 5 9.50337855599152e-05 0.01742602847883645 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA Curated_gene_sets REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS 14 3 9.841356248209078e-05 0.0174636453939994 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Curated_gene_sets REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES 70 5 0.00010180433806649016 0.017500801990742575 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES Curated_gene_sets REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION 71 5 0.00010893929228144789 0.018159849904249844 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION Curated_gene_sets KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 115 6 0.00011809248718558173 0.019106669764937797 HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS Curated_gene_sets BROWNE_HCMV_INFECTION_20HR_UP 229 8 0.00014673715743346774 0.023062888658328742 PTPN11:IREB2:FURIN:TOX3:APOE:PLAGL2:IGF2R:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/BROWNE_HCMV_INFECTION_20HR_UP Curated_gene_sets REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 231 8 0.0001557545321009193 0.023800157807976584 PRMT6:PTPN11:PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 Curated_gene_sets REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE 78 5 0.0001702245148705388 0.025308244764941458 HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE Curated_gene_sets REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS 124 6 0.00017854532288819137 0.02584678476863002 PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS Curated_gene_sets REACTOME_SIGNALING_BY_SCF_KIT 43 4 0.0001866484507739299 0.02632700327454842 SH2B3:PTPN11:FES:STAT5B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_SCF_KIT Curated_gene_sets REACTOME_MEIOTIC_RECOMBINATION 82 5 0.0002154105173588439 0.02962433139977501 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_MEIOTIC_RECOMBINATION Curated_gene_sets REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE 85 5 0.00025489078797890204 0.034198883528583905 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE Curated_gene_sets REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS 86 5 0.00026920038961385706 0.03525884150632923 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS Curated_gene_sets PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 48 4 0.00028685359095619945 0.03669724660116403 PTPN11:FES:STAT5B:PLG http://www.gsea-msigdb.org/gsea/msigdb/cards/PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Curated_gene_sets REACTOME_TRANSPORT_OF_SMALL_MOLECULES 721 14 0.00030972317958814636 0.03872243661169075 IREB2:PSMA4:FURIN:SPG7:LDLR:APOE:APOC1:SLC4A7:SLC22A7:SLC22A1:SLC22A2:SLC22A3:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSPORT_OF_SMALL_MOLECULES Curated_gene_sets REACTOME_HATS_ACETYLATE_HISTONES 138 6 0.00031860374288271003 0.038947537546617506 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HATS_ACETYLATE_HISTONES Curated_gene_sets REACTOME_RHO_GTPASES_ACTIVATE_PKNS 90 5 0.0003326253156742993 0.03930550332977142 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RHO_GTPASES_ACTIVATE_PKNS Curated_gene_sets REACTOME_REPRODUCTION 140 6 0.0003441639581053797 0.03930550332977142 ADAM30:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_REPRODUCTION Curated_gene_sets REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION 140 6 0.0003441639581053797 0.03930550332977142 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION Curated_gene_sets REACTOME_HDACS_DEACETYLATE_HISTONES 91 5 0.0003501126455478639 0.03930550332977142 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HDACS_DEACETYLATE_HISTONES Curated_gene_sets REACTOME_NEURONAL_SYSTEM 404 10 0.00036613045305244115 0.040281672444829573 GRM5:HTR3B:ALDH2:CHRNA5:CHRNA3:CHRNB4:TUBB3:TUBB3:KCNK3:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEURONAL_SYSTEM Curated_gene_sets REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 264 8 0.00038393669217663223 0.040957640881489614 HTR3B:ALDH2:CHRNA5:CHRNA3:CHRNB4:TUBB3:TUBB3:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Curated_gene_sets REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3 93 5 0.0003871654837006835 0.040957640881489614 TCF7L2:PSMA4:KAT2A:FOXO3:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3 Curated_gene_sets REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM 5 2 0.00043106249238765475 0.043912495752305346 NOTCH2:POFUT1 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM Curated_gene_sets REACTOME_CHYLOMICRON_CLEARANCE 5 2 0.00043106249238765475 0.043912495752305346 LDLR:APOE http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CHYLOMICRON_CLEARANCE Curated_gene_sets REACTOME_DEPURINATION 54 4 0.0004521404033373022 0.044414720692116064 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DEPURINATION Curated_gene_sets SCHEIDEREIT_IKK_INTERACTING_PROTEINS 54 4 0.0004521404033373022 0.044414720692116064 FANCA:CASP8:HTT:FOXO3 http://www.gsea-msigdb.org/gsea/msigdb/cards/SCHEIDEREIT_IKK_INTERACTING_PROTEINS Curated_gene_sets HOQUE_METHYLATED_IN_CANCER 55 4 0.00048511776005883144 0.04681811926462512 APOC1:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/HOQUE_METHYLATED_IN_CANCER Curated_gene_sets DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 345 9 0.0004966877109158342 0.04710826030600007 AK5:CELSR2:TCF7L2:KAT2A:PEPD:HIST1H4G:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP KEGG KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 115 6 0.00011809248718558173 0.0219652026165182 HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS Reactome REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 104 9 3.024262643678749e-08 4.533369702874445e-05 NOTCH2:FURIN:KAT2A:POFUT1:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Reactome REACTOME_SIGNALING_BY_NOTCH 228 11 3.562974878335424e-07 0.00026704496713124003 NOTCH2:PSMA4:FURIN:KAT2A:POFUT1:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:HDAC9 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_NOTCH Reactome REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE 120 8 1.3571344745855617e-06 0.0006781148591345856 MAPKAPK5:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE Reactome REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT 15 4 2.3835309337422266e-06 0.0008468211882408748 SLC22A7:SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Reactome REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT 5 3 2.8246203743858396e-06 0.0008468211882408748 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT Reactome REACTOME_CELLULAR_SENESCENCE 189 9 4.797185377175365e-06 0.0011984968133976453 MAPKAPK5:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_SENESCENCE Reactome REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP 105 7 6.362469433740618e-06 0.0013624773830253122 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP Reactome REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE 71 6 7.622942349595333e-06 0.0014283488227554257 FURIN:LDLR:APOE:APOC1:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE Reactome REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS 9 3 2.3269441882912182e-05 0.003503478984250009 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS Reactome REACTOME_FORMATION_OF_THE_BETA_CATENIN:TCF_TRANSACTIVATING_COMPLEX 88 6 2.6312183685548415e-05 0.003503478984250009 TCF7L2:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_FORMATION_OF_THE_BETA_CATENIN:TCF_TRANSACTIVATING_COMPLEX Reactome REACTOME_CELLULAR_RESPONSES_TO_STRESS 429 12 2.8981831761141522e-05 0.003503478984250009 NOX4:MAPKAPK5:PSMA4:TUBB3:TUBB3:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_RESPONSES_TO_STRESS Reactome REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM 10 3 3.3080806469677336e-05 0.003503478984250009 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Reactome REACTOME_ORGANIC_CATION_TRANSPORT 10 3 3.3080806469677336e-05 0.003503478984250009 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ORGANIC_CATION_TRANSPORT Reactome REACTOME_NEUROTRANSMITTER_CLEARANCE 10 3 3.3080806469677336e-05 0.003503478984250009 ALDH2:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEUROTRANSMITTER_CLEARANCE Reactome REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION 93 6 3.602299518645112e-05 0.003503478984250009 PRMT6:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION Reactome REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 1194 21 3.739537274716487e-05 0.003503478984250009 PRMT6:NOTCH2:TCF7L2:NR2C1:MAPKAPK5:PTPN11:PSMA4:PRDM7:KAT2A:APOE:HTT:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:FOXO3:HDAC9:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Reactome REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 11 3 4.526552435469183e-05 0.003774049877699362 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Reactome REACTOME_CELLULAR_RESPONSES_TO_EXTERNAL_STIMULI 523 13 4.5318811073107746e-05 0.003774049877699362 NOX4:MAPKAPK5:PSMA4:TUBB3:TUBB3:TOMM40:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_RESPONSES_TO_EXTERNAL_STIMULI Reactome REACTOME_DNA_METHYLATION 60 5 4.8435350539933506e-05 0.003821294234703175 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DNA_METHYLATION Reactome REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION 100 6 5.424621659810529e-05 0.004065753934027992 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION Reactome REACTOME_PLASMA_LIPOPROTEIN_REMODELING 32 4 5.754081162805183e-05 0.0041073179347833185 FURIN:APOE:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_REMODELING Reactome REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 63 5 6.135326662294666e-05 0.004180388484899865 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 Reactome REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION 64 5 6.620145802910391e-05 0.004220713820765947 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION Reactome REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION 104 6 6.757647211366426e-05 0.004220713820765947 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION Reactome REACTOME_AMYLOID_FIBER_FORMATION 105 6 7.128641166811531e-05 0.004274333243620193 FURIN:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_AMYLOID_FIBER_FORMATION Reactome REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA 69 5 9.50337855599152e-05 0.005450167955773883 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA Reactome REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS 14 3 9.841356248209078e-05 0.005450167955773883 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Reactome REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES 70 5 0.00010180433806649016 0.005450167955773883 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES Reactome REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION 71 5 0.00010893929228144789 0.005631034452754841 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION Reactome REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 231 8 0.0001557545321009193 0.007782534787309267 PRMT6:PTPN11:PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 Reactome REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE 78 5 0.0001702245148705388 0.00823117896099799 HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE Reactome REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS 124 6 0.00017854532288819137 0.008363732469043716 PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS Reactome REACTOME_SIGNALING_BY_SCF_KIT 43 4 0.0001866484507739299 0.00847836447606427 SH2B3:PTPN11:FES:STAT5B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_SCF_KIT Reactome REACTOME_MEIOTIC_RECOMBINATION 82 5 0.0002154105173588439 0.009497069574144323 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_MEIOTIC_RECOMBINATION Reactome REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE 85 5 0.00025489078797890204 0.010916608319439263 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE Reactome REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS 86 5 0.00026920038961385706 0.011209205111976994 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS Reactome REACTOME_TRANSPORT_OF_SMALL_MOLECULES 721 14 0.00030972317958814636 0.012495687039910665 IREB2:PSMA4:FURIN:SPG7:LDLR:APOE:APOC1:SLC4A7:SLC22A7:SLC22A1:SLC22A2:SLC22A3:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSPORT_OF_SMALL_MOLECULES Reactome REACTOME_HATS_ACETYLATE_HISTONES 138 6 0.00031860374288271003 0.012495687039910665 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HATS_ACETYLATE_HISTONES Reactome REACTOME_RHO_GTPASES_ACTIVATE_PKNS 90 5 0.0003326253156742993 0.012495687039910665 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RHO_GTPASES_ACTIVATE_PKNS Reactome REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION 140 6 0.0003441639581053797 0.012495687039910665 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION Reactome REACTOME_REPRODUCTION 140 6 0.0003441639581053797 0.012495687039910665 ADAM30:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_REPRODUCTION Reactome REACTOME_HDACS_DEACETYLATE_HISTONES 91 5 0.0003501126455478639 0.012495687039910665 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HDACS_DEACETYLATE_HISTONES Reactome REACTOME_NEURONAL_SYSTEM 404 10 0.00036613045305244115 0.012763477886642076 GRM5:HTR3B:ALDH2:CHRNA5:CHRNA3:CHRNB4:TUBB3:TUBB3:KCNK3:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEURONAL_SYSTEM Reactome REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 264 8 0.00038393669217663223 0.012896912445940545 HTR3B:ALDH2:CHRNA5:CHRNA3:CHRNB4:TUBB3:TUBB3:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Reactome REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3 93 5 0.0003871654837006835 0.012896912445940545 TCF7L2:PSMA4:KAT2A:FOXO3:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3 Reactome REACTOME_CHYLOMICRON_CLEARANCE 5 2 0.00043106249238765475 0.01374814204444882 LDLR:APOE http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CHYLOMICRON_CLEARANCE Reactome REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM 5 2 0.00043106249238765475 0.01374814204444882 NOTCH2:POFUT1 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM Reactome REACTOME_DEPURINATION 54 4 0.0004521404033373022 0.0141199680125545 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DEPURINATION Reactome REACTOME_GENE_EXPRESSION_TRANSCRIPTION 1451 21 0.0005562100123015983 0.01701548588653257 PRMT6:NOTCH2:TCF7L2:NR2C1:MAPKAPK5:PTPN11:PSMA4:PRDM7:KAT2A:APOE:HTT:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:FOXO3:HDAC9:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_GENE_EXPRESSION_TRANSCRIPTION Reactome REACTOME_SIGNALING_BY_PDGF 58 4 0.0005943080591131061 0.01781735561221092 PTPN11:FURIN:STAT5B:PLG http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_PDGF Reactome REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION 103 5 0.00061867618033164 0.017834530659944777 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION Reactome REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS 103 5 0.00061867618033164 0.017834530659944777 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS Reactome REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION 61 4 0.0007198955140128974 0.020360818405761 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION Reactome REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY 27 3 0.0007425284107638965 0.02061203866176076 NOTCH2:KAT2A:HDAC9 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Reactome REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT 226 7 0.0007855294323493172 0.021409247619847756 TCF7L2:PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT Reactome REACTOME_HIGHLY_SODIUM_PERMEABLE_ACETYLCHOLINE_NICOTINIC_RECEPTORS 7 2 0.0008973798120865512 0.023599514707328777 CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_SODIUM_PERMEABLE_ACETYLCHOLINE_NICOTINIC_RECEPTORS Reactome REACTOME_STAT5_ACTIVATION 7 2 0.0008973798120865512 0.023599514707328777 PTPN11:STAT5B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_STAT5_ACTIVATION Reactome REACTOME_MEIOSIS 114 5 0.0009791514945020274 0.025306001556181706 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_MEIOSIS Reactome REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ 67 4 0.0010254925409054064 0.026054463030800074 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ Reactome REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION 384 9 0.0010611670824462033 0.02651149094311431 TCF7L2:FGFR2:BRAP:PTPN11:PSMA4:KAT2A:STAT5B:FOXO3:HDAC9 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION Reactome REACTOME_ACTIVATION_OF_HOX_GENES_DURING_DIFFERENTIATION 118 5 0.0011426939497398412 0.028080298863279046 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACTIVATION_OF_HOX_GENES_DURING_DIFFERENTIATION Reactome REACTOME_NUCLEOSOME_ASSEMBLY 71 4 0.0012737515207185115 0.030796024670274983 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NUCLEOSOME_ASSEMBLY Reactome REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE 33 3 0.001345446039742549 0.03201307323133462 LDLR:APOE:APOC1 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE Reactome REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE 75 4 0.0015612606348606067 0.03656765143212577 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE Reactome REACTOME_RMTS_METHYLATE_HISTONE_ARGININES 76 4 0.0016396334477996304 0.037812469819256095 PRMT6:HIST1H4F:HIST1H3G:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RMTS_METHYLATE_HISTONE_ARGININES Reactome REACTOME_MEIOTIC_SYNAPSIS 77 4 0.001720700678516859 0.03908076238025411 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_MEIOTIC_SYNAPSIS Reactome REACTOME_CHYLOMICRON_REMODELING 10 2 0.0018980249871158254 0.04246476799532272 APOE:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CHYLOMICRON_REMODELING Reactome REACTOME_GENE_SILENCING_BY_RNA 133 5 0.0019401336105842738 0.04276853356273274 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_GENE_SILENCING_BY_RNA Reactome REACTOME_TELOMERE_MAINTENANCE 80 4 0.0019805468596690566 0.04296474395737975 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TELOMERE_MAINTENANCE Reactome REACTOME_CHROMATIN_ORGANIZATION 266 7 0.0020063589573159324 0.04296474395737975 PRMT6:KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CHROMATIN_ORGANIZATION Reactome REACTOME_SIGNALING_BY_LEPTIN 11 2 0.0023097493122209755 0.048764989000271014 PTPN11:STAT5B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_LEPTIN Reactome REACTOME_MITOTIC_PROPHASE 139 5 0.002351952279875747 0.04896633982685757 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_MITOTIC_PROPHASE Canonical_Pathways REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 104 9 3.024262643678749e-08 6.650353553449569e-05 NOTCH2:FURIN:KAT2A:POFUT1:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Canonical_Pathways REACTOME_SIGNALING_BY_NOTCH 228 11 3.562974878335424e-07 0.0003917490878729799 NOTCH2:PSMA4:FURIN:KAT2A:POFUT1:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:HDAC9 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_NOTCH Canonical_Pathways REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE 120 8 1.3571344745855617e-06 0.0009947795698712167 MAPKAPK5:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE Canonical_Pathways REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT 15 4 2.3835309337422266e-06 0.0012422680406548921 SLC22A7:SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Canonical_Pathways REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT 5 3 2.8246203743858396e-06 0.0012422680406548921 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT Canonical_Pathways REACTOME_CELLULAR_SENESCENCE 189 9 4.797185377175365e-06 0.0017581684407347712 MAPKAPK5:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_SENESCENCE Canonical_Pathways REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP 105 7 6.362469433740618e-06 0.001998724326399374 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP Canonical_Pathways REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE 71 6 7.622942349595333e-06 0.002095356278345017 FURIN:LDLR:APOE:APOC1:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE Canonical_Pathways REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS 9 3 2.3269441882912182e-05 0.005139526541938472 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS Canonical_Pathways REACTOME_FORMATION_OF_THE_BETA_CATENIN:TCF_TRANSACTIVATING_COMPLEX 88 6 2.6312183685548415e-05 0.005139526541938472 TCF7L2:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_FORMATION_OF_THE_BETA_CATENIN:TCF_TRANSACTIVATING_COMPLEX Canonical_Pathways REACTOME_CELLULAR_RESPONSES_TO_STRESS 429 12 2.8981831761141522e-05 0.005139526541938472 NOX4:MAPKAPK5:PSMA4:TUBB3:TUBB3:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_RESPONSES_TO_STRESS Canonical_Pathways REACTOME_NEUROTRANSMITTER_CLEARANCE 10 3 3.3080806469677336e-05 0.005139526541938472 ALDH2:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEUROTRANSMITTER_CLEARANCE Canonical_Pathways REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM 10 3 3.3080806469677336e-05 0.005139526541938472 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Canonical_Pathways REACTOME_ORGANIC_CATION_TRANSPORT 10 3 3.3080806469677336e-05 0.005139526541938472 SLC22A1:SLC22A2:SLC22A3 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ORGANIC_CATION_TRANSPORT Canonical_Pathways REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION 93 6 3.602299518645112e-05 0.005139526541938472 PRMT6:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION Canonical_Pathways REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 1194 21 3.739537274716487e-05 0.005139526541938472 PRMT6:NOTCH2:TCF7L2:NR2C1:MAPKAPK5:PTPN11:PSMA4:PRDM7:KAT2A:APOE:HTT:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:FOXO3:HDAC9:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Canonical_Pathways REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS 11 3 4.526552435469183e-05 0.005536448086097997 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Canonical_Pathways REACTOME_CELLULAR_RESPONSES_TO_EXTERNAL_STIMULI 523 13 4.5318811073107746e-05 0.005536448086097997 NOX4:MAPKAPK5:PSMA4:TUBB3:TUBB3:TOMM40:HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CELLULAR_RESPONSES_TO_EXTERNAL_STIMULI Canonical_Pathways REACTOME_DNA_METHYLATION 60 5 4.8435350539933506e-05 0.005605754517753356 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DNA_METHYLATION Canonical_Pathways REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION 100 6 5.424621659810529e-05 0.005964371514961676 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION Canonical_Pathways REACTOME_PLASMA_LIPOPROTEIN_REMODELING 32 4 5.754081162805183e-05 0.006025344989051713 FURIN:APOE:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_REMODELING Canonical_Pathways REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 63 5 6.135326662294666e-05 0.006132537877448168 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACTIVATED_PKN1_STIMULATES_TRANSCRIPTION_OF_AR_ANDROGEN_RECEPTOR_REGULATED_GENES_KLK2_AND_KLK3 Canonical_Pathways REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION 64 5 6.620145802910391e-05 0.006191694257414488 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIRT1_NEGATIVELY_REGULATES_RRNA_EXPRESSION Canonical_Pathways REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION 104 6 6.757647211366426e-05 0.006191694257414488 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION Canonical_Pathways REACTOME_AMYLOID_FIBER_FORMATION 105 6 7.128641166811531e-05 0.006270352770327422 FURIN:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_AMYLOID_FIBER_FORMATION Canonical_Pathways REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA 69 5 9.50337855599152e-05 0.007995276407436138 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRC2_METHYLATES_HISTONES_AND_DNA Canonical_Pathways REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS 14 3 9.841356248209078e-05 0.007995276407436138 CHRNA5:CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Canonical_Pathways REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES 70 5 0.00010180433806649016 0.007995276407436138 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES Canonical_Pathways REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION 71 5 0.00010893929228144789 0.00826060357678979 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION Canonical_Pathways KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 115 6 0.00011809248718558173 0.00865617931070314 HIST1H4F:HIST1H4G:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS Canonical_Pathways REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 231 8 0.0001557545321009193 0.011048523099674887 PRMT6:PTPN11:PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 Canonical_Pathways REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE 78 5 0.0001702245148705388 0.01169761588125984 HIST1H1D:HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE Canonical_Pathways REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS 124 6 0.00017854532288819137 0.011897611061549478 PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_HSCS Canonical_Pathways REACTOME_SIGNALING_BY_SCF_KIT 43 4 0.0001866484507739299 0.01207176303681976 SH2B3:PTPN11:FES:STAT5B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_SCF_KIT Canonical_Pathways REACTOME_MEIOTIC_RECOMBINATION 82 5 0.0002154105173588439 0.013533935076345649 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_MEIOTIC_RECOMBINATION Canonical_Pathways REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE 85 5 0.00025489078797890204 0.015569578965711267 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RNA_POLYMERASE_I_PROMOTER_ESCAPE Canonical_Pathways REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS 86 5 0.00026920038961385706 0.015999233966510047 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_OF_GRANULOPOIESIS Canonical_Pathways PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 48 4 0.00028685359095619945 0.0165997643819127 PTPN11:FES:STAT5B:PLG http://www.gsea-msigdb.org/gsea/msigdb/cards/PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Canonical_Pathways REACTOME_TRANSPORT_OF_SMALL_MOLECULES 721 14 0.00030972317958814636 0.01746362235677779 IREB2:PSMA4:FURIN:SPG7:LDLR:APOE:APOC1:SLC4A7:SLC22A7:SLC22A1:SLC22A2:SLC22A3:LPA:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSPORT_OF_SMALL_MOLECULES Canonical_Pathways REACTOME_HATS_ACETYLATE_HISTONES 138 6 0.00031860374288271003 0.01749767517181256 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HATS_ACETYLATE_HISTONES Canonical_Pathways REACTOME_RHO_GTPASES_ACTIVATE_PKNS 90 5 0.0003326253156742993 0.01749767517181256 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_RHO_GTPASES_ACTIVATE_PKNS Canonical_Pathways REACTOME_REPRODUCTION 140 6 0.0003441639581053797 0.01749767517181256 ADAM30:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_REPRODUCTION Canonical_Pathways REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION 140 6 0.0003441639581053797 0.01749767517181256 KAT2A:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION Canonical_Pathways REACTOME_HDACS_DEACETYLATE_HISTONES 91 5 0.0003501126455478639 0.01749767517181256 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HDACS_DEACETYLATE_HISTONES Canonical_Pathways REACTOME_NEURONAL_SYSTEM 404 10 0.00036613045305244115 0.01789157480582929 GRM5:HTR3B:ALDH2:CHRNA5:CHRNA3:CHRNB4:TUBB3:TUBB3:KCNK3:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEURONAL_SYSTEM Canonical_Pathways REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 264 8 0.00038393669217663223 0.01811440209910219 HTR3B:ALDH2:CHRNA5:CHRNA3:CHRNB4:TUBB3:TUBB3:SLC22A1:SLC22A2 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Canonical_Pathways REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3 93 5 0.0003871654837006835 0.01811440209910219 TCF7L2:PSMA4:KAT2A:FOXO3:CDKN2A http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3 Canonical_Pathways REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM 5 2 0.00043106249238765475 0.019345028995111282 NOTCH2:POFUT1 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM Canonical_Pathways REACTOME_CHYLOMICRON_CLEARANCE 5 2 0.00043106249238765475 0.019345028995111282 LDLR:APOE http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_CHYLOMICRON_CLEARANCE Canonical_Pathways REACTOME_DEPURINATION 54 4 0.0004521404033373022 0.019885134938774553 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DEPURINATION Canonical_Pathways REACTOME_GENE_EXPRESSION_TRANSCRIPTION 1451 21 0.0005562100123015983 0.02398246700100421 PRMT6:NOTCH2:TCF7L2:NR2C1:MAPKAPK5:PTPN11:PSMA4:PRDM7:KAT2A:APOE:HTT:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H:FOXO3:HDAC9:TWIST1:CDKN2A:CDKN2B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_GENE_EXPRESSION_TRANSCRIPTION Canonical_Pathways REACTOME_SIGNALING_BY_PDGF 58 4 0.0005943080591131061 0.025132373499802314 PTPN11:FURIN:STAT5B:PLG http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_SIGNALING_BY_PDGF Canonical_Pathways REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION 103 5 0.00061867618033164 0.025193868899060674 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NEGATIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION Canonical_Pathways REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS 103 5 0.00061867618033164 0.025193868899060674 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS Canonical_Pathways BIOCARTA_LDL_PATHWAY 6 2 0.0006437828357831593 0.025739608288857588 LDLR:LPL http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_LDL_PATHWAY Canonical_Pathways REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION 61 4 0.0007198955140128974 0.028268754202042168 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_BASE_EXCISION_REPAIR_AP_SITE_FORMATION Canonical_Pathways REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY 27 3 0.0007425284107638965 0.028645964478417694 NOTCH2:KAT2A:HDAC9 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Canonical_Pathways REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT 226 7 0.0007855294323493172 0.029782400374761184 TCF7L2:PSMA4:HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT Canonical_Pathways REACTOME_STAT5_ACTIVATION 7 2 0.0008973798120865512 0.0328889701129721 PTPN11:STAT5B http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_STAT5_ACTIVATION Canonical_Pathways REACTOME_HIGHLY_SODIUM_PERMEABLE_ACETYLCHOLINE_NICOTINIC_RECEPTORS 7 2 0.0008973798120865512 0.0328889701129721 CHRNA3:CHRNB4 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_HIGHLY_SODIUM_PERMEABLE_ACETYLCHOLINE_NICOTINIC_RECEPTORS Canonical_Pathways REACTOME_MEIOSIS 114 5 0.0009791514945020274 0.03529760879360587 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_MEIOSIS Canonical_Pathways REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ 67 4 0.0010254925409054064 0.03637190479759659 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ Canonical_Pathways REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION 384 9 0.0010611670824462033 0.03703978435395557 TCF7L2:FGFR2:BRAP:PTPN11:PSMA4:KAT2A:STAT5B:FOXO3:HDAC9 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION Canonical_Pathways REACTOME_ACTIVATION_OF_HOX_GENES_DURING_DIFFERENTIATION 118 5 0.0011426939497398412 0.03926224992934236 HIST1H4F:HIST1H2BH:HIST1H3G:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_ACTIVATION_OF_HOX_GENES_DURING_DIFFERENTIATION Canonical_Pathways REACTOME_NUCLEOSOME_ASSEMBLY 71 4 0.0012737515207185115 0.04309199375476934 HIST1H4F:HIST1H2BH:HIST1H2BI:HIST1H4H http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_NUCLEOSOME_ASSEMBLY Canonical_Pathways PID_EPO_PATHWAY 33 3 0.001345446039742549 0.044158743901400975 SH2B3:PTPN11:STAT5B http://www.gsea-msigdb.org/gsea/msigdb/cards/PID_EPO_PATHWAY Canonical_Pathways REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE 33 3 0.001345446039742549 0.044158743901400975 LDLR:APOE:APOC1 http://www.gsea-msigdb.org/gsea/msigdb/cards/REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE