trait1 chr1 nlp trait pvalue_text mapped_id trait_id rsid chr pos source gene dist repeat HMDB0011594 22 26 SERUM METABOLITE LEVELS (LACTOSYL-N-BEHENOYL-SPHINGOSINE (D18:1/22:0)*) SERUM METABOLITE MEASUREMENT HMDB0011594 rs12628541 22 42697692 Feofanova EV et al,33031748 A4GALT 5571 0 HMDB0011595 22 23 METABOLITE LEVELS (HEX2CER D18:1/24:0) SPHINGOLIPID MEASUREMENT HMDB0011595 rs3761467 22 42698079 Chai JF et al,31628463 A4GALT 5958 1 HMDB0000067 7 26.69897 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs59509802 7 21557869 Sakaue S et al,34594039 ABCB1 65945148 0 HMDB0000054 10 111.69897 TOTAL BILIRUBIN LEVELS BILIRUBIN MEASUREMENT HMDB0000054 rs17476364 10 69334748 Sakaue S et al,34594039 ABCC2 30447892 0 HMDB0000067 4 45.39794001 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs976002 4 68477569 Liu DJ et al,29083408 ABCG2 19612581 0 HMDB0002212 20 12.22184875 VERY LONG-CHAIN SATURATED FATTY ACID LEVELS (FATTY ACID 20:0) VERY LONG-CHAIN SATURATED FATTY ACID MEASUREMENT HMDB0002212 rs680379 20 12988752 Lemaitre RN et al,25378659 ACOT8 32852969 0 HMDB0000207 20 7.522878745 C-REACTIVE PROTEIN (RED BLOOD CELL FATTY ACID LEVEL INTERACTION) (OA) FATTY ACID MEASUREMENT,OLEIC ACID MEASUREMENT,C-REACTIVE PROTEIN MEASUREMENT HMDB0000207 rs3762220 20 18797336 Veenstra J et al,28820441 ACOT8 27044385 1 HMDB0000586 16 10 POTASSIUM LEVELS POTASSIUM MEASUREMENT HMDB0000586 rs118070237 16 56795510 Kanai M et al,29403010 ACSM2B 36259284 0 HMDB0004089 17 42.39794001 SERUM METABOLITE LEVELS (N-FORMYLANTHRANILIC ACID) SERUM METABOLITE MEASUREMENT HMDB0004089 rs72897843 17 78204884 Feofanova EV et al,33031748 AFMID 17526 0 HMDB0000294 1 125.2218487 BLOOD UREA NITROGEN LEVELS BLOOD UREA NITROGEN MEASUREMENT HMDB0000294 rs760077 1 155208991 Sakaue S et al,34594039 AGMAT 139637292 0 HMDB0000123 2 1631.522879 GLYCINE LEVELS GLYCINE MEASUREMENT HMDB0000123 rs715 2 210678331 Wittemans LBL et al,30837465 AGXT 30190493 0 HMDB0000517|HMDB0000123 2 14.69897 BLOOD METABOLITE LEVELS (ARGININE / GLYCINE) BLOOD METABOLITE MEASUREMENT HMDB0000517|HMDB0000123 rs6546838 2 73452153 Burkhardt R et al,26401656 AGXT 167416671 1 HMDB0000742 7 16 PLASMA HOMOCYSTEINE LEVELS (POST-METHIONINE LOAD TEST) HOMOCYSTEINE MEASUREMENT HMDB0000742 rs4948102 7 56029572 Williams SR et al,24651765 AHCYL2 73195458 0 HMDB0000248|HMDB0000265 4 31.04575749 HYPOTHYROIDISM HYPOTHYROIDISM HMDB0000248|HMDB0000265 rs17025117 4 148744675 Kichaev G et al,30595370 ALB 75347561 0 HMDB0001161 12 66.69897 SERUM METABOLITE LEVELS (DEOXYCARNITINE) SERUM METABOLITE MEASUREMENT HMDB0001161 rs11062102 12 239619 Feofanova EV et al,33031748 ALDH2 111527268 0 HMDB0000294 2 52.69897 BLOOD UREA NITROGEN LEVELS BLOOD UREA NITROGEN MEASUREMENT HMDB0000294 rs7576384 2 113235808 Sakaue S et al,34594039 ALLC 109577608 0 HMDB0000202 2 13.69897 URINARY METABOLITE LEVELS IN CHRONIC KIDNEY DISEASE (METHYLMALONATE (MMA)) URINARY METABOLITE MEASUREMENT HMDB0000202 rs291468 2 190323393 Schlosser P et al,31959995 AOX1 10262621 0 HMDB0004194 2 11.22184875 BLOOD METABOLITE LEVELS (X-12095--N1-METHYL-3-PYRIDONE-4-CARBOXAMIDE) BLOOD METABOLITE MEASUREMENT HMDB0004194 rs6430553 2 134873830 Shin SY et al,24816252 AOX1 65712184 1 HMDB0000214|HMDB0003374 6 26.09691001 SERUM METABOLITE LEVELS (ORNITHINE) SERUM METABOLITE MEASUREMENT HMDB0000214|HMDB0003374 rs17788484 6 131573218 Feofanova EV et al,33031748 ARG1 102386 0 HMDB0000214 14 12 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR ONE OTHER PFAA) (ORN (ADJUSTED FOR ASN)) AMINO ACID MEASUREMENT HMDB0000214 rs1744297 14 104102135 Imaizumi A et al,30659259 ARG2 36482215 0 HMDB0000294 14 9.301029996 BLOOD UREA NITROGEN LEVELS BLOOD UREA NITROGEN MEASUREMENT HMDB0000294 rs4906214 14 102529331 Sakaue S et al,34594039 ARG2 34909411 1 HMDB0000517 4 21.69897 L-ARGININE LEVELS (RANDOM EFFECTS MODEL) L-ARGININE MEASUREMENT HMDB0000517 rs71640036 4 186239966 Zhang W et al,27656708 ART3 110228782 0 HMDB0011625 10 23.22184875 ARSENIC METABOLISM (PERCENT DIMETHYLARSINATE) URINARY ARSENIC MEASUREMENT HMDB0011625 rs12768205 10 102888092 Balakrishnan P et al,27352405 AS3MT 18622 0 ~HMDB0004872 10 8 METABOLITE LEVELS (HEX2CER D18:2/16:0) SPHINGOLIPID MEASUREMENT ~HMDB0004872 rs3001860 10 50668182 Chai JF et al,31628463 ASAH2 485404 0 HMDB0000142|HMDB0000254 8 28 URINARY METABOLITES (FORMATE/SUCCINATE RATIO) METABOLITE MEASUREMENT HMDB0000142|HMDB0000254 rs4921914 8 18414928 Suhre K et al,21572414 ASPH 43085628 0 HMDB0000586 X 10.52287875 POTASSIUM LEVELS POTASSIUM MEASUREMENT HMDB0000586 rs5912570 X 78218174 Kanai M et al,29403010 ATP1B4 42143911 0 HMDB0009815 19 27 PHOSPHATIDYLINOSITOL LEVELS (PI(18:0;0-20:4;0)) PHOSPHATIDYLINOSITOL MEASUREMENT HMDB0009815 rs8736 19 54173495 Tabassum R et al,31551469 ATP8B3 52391420 0 HMDB0009809 19 20.69897 SERUM METABOLITE LEVELS (1-STEAROYL-2-LINOLEOYL-GPI (18:0/18:2)) SERUM METABOLITE MEASUREMENT HMDB0009809 rs641738 19 54173068 Feofanova EV et al,33031748 ATP8B3 52390993 1 HMDB0009814 19 15.22184875 PHOSPHATIDYLINOSITOL LEVELS (PI(18:0;0-20:3;0)) PHOSPHATIDYLINOSITOL MEASUREMENT HMDB0009814 rs8736 19 54173495 Tabassum R et al,31551469 ATP8B3 52391420 1 HMDB0009784 19 13 SERUM METABOLITE LEVELS (1-PALMITOYL-2-LINOLEOYL-GPI (16:0/18:2)) SERUM METABOLITE MEASUREMENT HMDB0009784 rs8736 19 54173495 Feofanova EV et al,33031748 ATP8B3 52391420 1 HMDB0009783 19 12.22184875 SERUM METABOLITE LEVELS (1-PALMITOYL-2-OLEOYL-GPI (16:0/18:1)*) SERUM METABOLITE MEASUREMENT HMDB0009783 rs8736 19 54173495 Feofanova EV et al,33031748 ATP8B3 52391420 1 HMDB0000588 10 14.22184875 SODIUM LEVELS SODIUM MEASUREMENT HMDB0000588 rs4919683 10 102825368 Kanai M et al,29403010 AVPI1 5147944 0 HMDB0001161 11 12 SERUM METABOLITE LEVELS (DEOXYCARNITINE) SERUM METABOLITE MEASUREMENT HMDB0001161 rs2304913 11 27125577 Feofanova EV et al,33031748 BBOX1 84852 0 HMDB0000172|HMDB0002579 12 327.2218487 BLOOD METABOLITE RATIOS (ISOLEUCINE/X-11529) BLOOD METABOLITE MEASUREMENT HMDB0000172|HMDB0002579 rs4149056 12 21178615 Shin SY et al,24816252 BCAT1 3631409 0 HMDB0000687 12 7.522878745 PLASMA FREE AMINO ACID LEVELS (LEU) LEUCINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000687 rs10437868 12 77508538 Imaizumi A et al,30659259 BCAT1 52698514 1 HMDB0000094 5 24.39794001 METABOLITE LEVELS (SMALL MOLECULES AND PROTEIN MEASURES) (CITRATE) BLOOD METABOLITE MEASUREMENT,PROTEIN MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000094 rs2921604 5 14867839 Kettunen J et al,27005778 BHMT 64243970 0 HMDB0000054 7 35 TOTAL BILIRUBIN LEVELS BILIRUBIN MEASUREMENT HMDB0000054 rs2106727 7 17248374 Sakaue S et al,34594039 BLVRA 26510306 0 HMDB0000054 19 42.30103 DIRECT BILIRUBIN LEVELS BILIRUBIN MEASUREMENT HMDB0000054 rs58542926 19 19268740 Sinnott-Armstrong N et al,33462484 BLVRB 21179025 0 HMDB0000294 8 40 BLOOD UREA NITROGEN LEVELS BLOOD UREA NITROGEN MEASUREMENT HMDB0000294 rs7834797 8 23902022 Sakaue S et al,34594039 CA2 61561946 0 HMDB0000742 21 25.52287875 PLASMA HOMOCYSTEINE LEVELS (POST-METHIONINE LOAD TEST) HOMOCYSTEINE MEASUREMENT HMDB0000742 rs234714 21 43067923 Williams SR et al,24651765 CBS 14732 0 HMDB0002174 19 35.39794001 VITAMIN B12 LEVELS VITAMIN B12 MEASUREMENT HMDB0002174 rs1047781 19 48703374 Lin X et al,22367966 CD320 40401247 0 ~HMDB0005384 9 18.22184875 TRIGLYCERIDE LEVELS TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs696825 9 83968161 Richardson TG et al,32203549 CEL 49093820 0 HMDB0000885 9 7.522878745 METABOLITE LEVELS (CE 16:0) CHOLESTERYL ESTER 16:0 MEASUREMENT HMDB0000885 rs2854925 9 132233164 Rhee EP et al,23823483 CEL 828817 1 ~HMDB0005384 16 57.09691001 TRIGLYCERIDES TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs12446515 16 56953103 Sakaue S et al,34594039 CES1 1150252 0 HMDB0000043 3 14.30103 BETAINE LEVELS METABOLITE MEASUREMENT HMDB0000043 rs17279437 3 45772602 Panyard DJ et al,33437055 CHDH 8039733 0 HMDB0001934 8 7.522878745 NICOTINE METABOLITE RATIO IN CURRENT SMOKERS NICOTINE METABOLITE RATIO HMDB0001934 rs2045966 8 97581926 Patel YM et al,27488534 CHRNA2 70122170 0 HMDB0001934 4 12 NICOTINE METABOLITE RATIO IN CURRENT SMOKERS NICOTINE METABOLITE RATIO HMDB0001934 rs34638591 4 68493505 Buchwald J et al,32157176 CHRNA9 28158172 0 HMDB0000883 22 13.22184875 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR ONE OTHER PFAA) (VAL (ADJUSTED FOR PRO)) AMINO ACID MEASUREMENT HMDB0000883 rs2238732 22 18927834 Imaizumi A et al,30659259 COMT 1013537 0 HMDB0015531 3 32.22184875 IRON STATUS BIOMARKERS (IRON LEVELS) SERUM IRON MEASUREMENT HMDB0015531 rs4854760 3 133779897 Bell S et al,33536631 CP 15382513 0 ~HMDB0000766 2 27.09691001 SERUM METABOLITE LEVELS (N-ACETYLALLIIN) SERUM METABOLITE MEASUREMENT ~HMDB0000766 rs2947860 2 73628259 Feofanova EV et al,33031748 CPS1 136849423 0 HMDB0000766 2 12.30103 URINARY METABOLITE MODULES (EIGENMETABOLITES) IN CHRONIC KIDNEY DISEASE (N-ACETYLALANINE, N-ACETYLMETHIONINE, N-ACETYLMETHIONINE SULFOXIDE, SARCOSINE, X-12199) URINARY METABOLITE MEASUREMENT HMDB0000766 rs4547554 2 73640735 Schlosser P et al,31959995 CPS1 136836947 1 ~HMDB0005384 1 303.30103 TRIGLYCERIDE LEVELS TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs9436661 1 62438904 Richardson TG et al,32203549 CPT2 9242112 0 HMDB0000482 1 19.69897 SERUM METABOLITE LEVELS (CAPRYLATE (8:0)) SERUM METABOLITE MEASUREMENT HMDB0000482 rs12760091 1 75645988 Feofanova EV et al,33031748 CPT2 22449196 1 HMDB0000062 1 15.52287875 BLOOD METABOLITE LEVELS (CARNITINE) BLOOD METABOLITE MEASUREMENT HMDB0000062 rs1466788 1 110076108 Shin SY et al,24816252 CPT2 56879316 1 HMDB0000535 1 14.69897 SERUM METABOLITE LEVELS (CAPROATE (6:0)) SERUM METABOLITE MEASUREMENT HMDB0000535 rs61797339 1 75724261 Feofanova EV et al,33031748 CPT2 22527469 1 HMDB0000222 1 13.22184875 SERUM METABOLITE LEVELS (PIMELOYLCARNITINE/3-METHYLADIPOYLCARNITINE (C7-DC)) SERUM METABOLITE MEASUREMENT HMDB0000222 rs4507958 1 46917369 Feofanova EV et al,33031748 CPT2 6279423 1 HMDB0013133|HMDB0000824 9 42.52287875 BLOOD METABOLITE LEVELS (METHYLMALONYLCARNITINE / PROPIONYLCARNITINE) BLOOD METABOLITE MEASUREMENT HMDB0013133|HMDB0000824 rs746872 9 129102748 Burkhardt R et al,26401656 CRAT 8606 0 HMDB0000294 3 152.69897 BLOOD UREA NITROGEN LEVELS BLOOD UREA NITROGEN MEASUREMENT HMDB0000294 rs9880162 3 188001560 Sakaue S et al,34594039 CTNNB1 146806819 0 HMDB0002174 10 12.69897 VITAMIN B LEVELS IN ISCHEMIC STROKE (VITAMIN B12) VITAMIN B12 MEASUREMENT HMDB0002174 rs1801222 10 17114152 Keene KL et al,25147783 CUBN 290186 0 HMDB0000374 6 15.69897 17-HYDROXYPROGESTERONE (17-OHP) LEVELS 17-HYDROXYPROGESTERONE MEASUREMENT HMDB0000374 rs145827824 6 32135972 Pott J et al,31169883 CYP21A2 97645 0 ~HMDB0004026 6 13.52287875 SERUM METABOLITE LEVELS (21-HYDROXYPREGNENOLONE DISULFATE) SERUM METABOLITE MEASUREMENT ~HMDB0004026 rs1177442 6 25808841 Feofanova EV et al,33031748 CYP21A2 6229486 1 HMDB0000067 2 208.2218487 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs10692845 2 21070464 Klarin D et al,30275531 CYP27A1 197711285 0 HMDB0012453 2 21.30103 SERUM METABOLITE LEVELS (3B-HYDROXY-5-CHOLENOIC ACID) SERUM METABOLITE MEASUREMENT HMDB0012453 rs1047891 2 210675783 Feofanova EV et al,33031748 CYP27A1 8105966 1 HMDB0000234 22 42.39794001 TOTAL TESTOSTERONE LEVELS TESTOSTERONE MEASUREMENT HMDB0000234 rs738409 22 43928847 Ruth KS et al,32042192 CYP2D6 1802348 0 HMDB0060472|HMDB0005038 22 15.09691001 RESPONSE TO SEROTONIN REUPTAKE INHIBITORS IN MAJOR DEPRESSIVE DISORDER (PLASMA DRUG AND METABOLITE LEVELS) (S-DDCT/S-DCT RATIO) UNIPOLAR DEPRESSION,RESPONSE TO SELECTIVE SEROTONIN REUPTAKE INHIBITOR HMDB0060472|HMDB0005038 rs1065852 22 42130692 Ji Y et al,24528284 CYP2D6 4193 1 HMDB0000151 22 7.522878745 ESTRADIOL LEVELS ESTRADIOL MEASUREMENT HMDB0000151 rs117826558 22 46374859 Ruth KS et al,32042192 CYP2D6 4248360 1 HMDB0015702 7 14 TICAGRELOR LEVELS IN INDIVIDUALS WITH ACUTE CORONARY SYNDROMES TREATED WITH TICAGRELOR TICAGRELOR MEASUREMENT HMDB0015702 rs62471956 7 99823462 Varenhorst C et al,25935875 CYP3A4 66502 0 @any|HMDB0000067 14 133 BLOOD METABOLITE RATIOS (X-08402/CHOLESTEROL) BLOOD METABOLITE MEASUREMENT @any|HMDB0000067 rs7157785 14 63768838 Shin SY et al,24816252 CYP46A1 35915460 0 HMDB0000067 14 15.52287875 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs17580 14 94380925 Klarin D et al,30275531 CYP46A1 5303373 1 HMDB0000067 8 153.69897 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs2954038 8 125495147 Sinnott-Armstrong N et al,33462484 CYP7A1 67004969 0 HMDB0059655 2 14.22184875 SERUM METABOLITE LEVELS (2-HYDROXYGLUTARATE) SERUM METABOLITE MEASUREMENT HMDB0059655 rs7370843 2 241734689 Feofanova EV et al,33031748 D2HGDH 87 0 HMDB0000161|HMDB0001310 12 12.22184875 METABOLITE LEVELS (SMALL MOLECULES AND PROTEIN MEASURES) (ALANINE) BLOOD METABOLITE MEASUREMENT,PROTEIN MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000161|HMDB0001310 rs4554975 12 46808031 Kettunen J et al,27005778 DAO 62050901 0 HMDB0001539 1 40 ASYMMETRICAL DIMETHYLARGININE LEVELS ASYMMETRICAL DIMETHYLARGININE MEASUREMENT,SERUM DIMETHYLARGININE MEASUREMENT HMDB0001539 rs28489187 1 85331427 Seppala I et al,24159190 DDAH1 12946 0 HMDB0001539|HMDB0003334 1 20 SERUM DIMETHYLARGININE LEVELS (ASYMMETRIC/SYMETRIC RATIO) SERUM DIMETHYLARGININE MEASUREMENT HMDB0001539|HMDB0003334 rs28489187 1 85331427 Seppala I et al,24159190 DDAH1 12946 1 HMDB0000929 7 7.522878745 PLASMA FREE AMINO ACID LEVELS (TRP) TRYPTOPHAN MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000929 rs75444260 7 635944 Imaizumi A et al,30659259 DDC 49822492 0 HMDB0001893 12 11.69897 SERUM METABOLITE LEVELS (ALPHA-TOCOPHEROL) SERUM METABOLITE MEASUREMENT HMDB0001893 rs10846744 12 124827879 Feofanova EV et al,33031748 DGKA 68900560 0 HMDB0000248|HMDB0000265 1 172.69897 HYPOTHYROIDISM HYPOTHYROIDISM HMDB0000248|HMDB0000265 rs2476601 1 113834946 Kichaev G et al,30595370 DIO1 59943707 0 HMDB0000248 1 33.30103 FREE THYROXINE CONCENTRATION THYROXINE MEASUREMENT HMDB0000248 rs2235544 1 53909897 Taylor PN et al,25743335 DIO1 18658 1 HMDB0000265 1 8.045757491 TRIIODOTHYRONINE LEVELS TRIIODOTHYRONINE MEASUREMENT HMDB0000265 rs67142165 1 22884066 Popovic M et al,30843173 DIO1 31007173 1 HMDB0000182|HMDB0003405 19 33 URINARY METABOLITES (H-NMR FEATURES) (3.0325, LYSINE) URINARY METABOLITE MEASUREMENT HMDB0000182|HMDB0003405 rs8101881 19 32873722 Rueedi R et al,24586186 DOT1L 30709789 0 HMDB0000300 1 11.69897 SERUM METABOLITE LEVELS (URACIL) SERUM METABOLITE MEASUREMENT HMDB0000300 rs111924138 1 97696155 Feofanova EV et al,33031748 DPYD 618412 0 HMDB0000452|HMDB0000650 4 10.30103 BLOOD METABOLITE LEVELS (2-AMINOBUTYRATE) BLOOD METABOLITE MEASUREMENT HMDB0000452|HMDB0000650 rs10022462 4 88322666 Shin SY et al,24816252 EGF 21590217 0 HMDB0000044 14 8 VITAMIN C LEVELS VITAMIN C MEASUREMENT HMDB0000044 rs10136000 14 104787244 Zheng JS et al,33203707 EGLN3 70863017 0 HMDB0000151 14 41.15490196 ESTRADIOL LEVELS ESTRADIOL MEASUREMENT HMDB0000151 rs34019140 14 106071252 Ruth KS et al,32042192 ESR2 41987020 0 HMDB0000224 1 12.15490196 URINARY METABOLITE LEVELS IN CHRONIC KIDNEY DISEASE (PHOSPHOETHANOLAMINE) URINARY METABOLITE MEASUREMENT HMDB0000224 rs1772719 1 21577881 Schlosser P et al,31959995 ETNK2 182553181 0 HMDB0000657 1 19.52287875 BLOOD TRACE ELEMENT (CU LEVELS) SERUM COPPER MEASUREMENT HMDB0000657 rs2769264 1 151372265 Evans DM et al,23720494 F5 18139686 0 HMDB0001999 11 57.30103 PLASMA OMEGA-3 POLYUNSATURATED FATTY ACID LEVEL (EICOSAPENTAENOIC ACID) EICOSAPENTAENOIC ACID MEASUREMENT HMDB0001999 rs174538 11 61792609 Lemaitre RN et al,21829377 FADS1 7018 0 HMDB0006547 11 21.22184875 SERUM METABOLITE LEVELS (STEARIDONATE (18:4N3)) SERUM METABOLITE MEASUREMENT HMDB0006547 rs174556 11 61813163 Feofanova EV et al,33031748 FADS2 20183 0 HMDB0000122 4 17.15490196 GLUCOSE LEVELS GLUCOSE MEASUREMENT HMDB0000122 rs116401167 4 184794531 Sakaue S et al,34594039 GBA3 162101617 0 HMDB0000122 X 11.69897 GLUCOSE LEVELS GLUCOSE MEASUREMENT HMDB0000122 rs4898432 X 153637314 Sakaue S et al,34594039 GLA 52244041 0 HMDB0012095 5 8.522878745 METABOLITE LEVELS (SM 24:1) SPHINGOMYELIN 24:1 MEASUREMENT HMDB0012095 rs4700347 5 59954679 Rhee EP et al,23823483 GM2A 91257471 0 HMDB0000684 16 25.04575749 BLOOD METABOLITE LEVELS (KYNURENINE) BLOOD METABOLITE MEASUREMENT HMDB0000684 rs8051149 16 87845216 Shin SY et al,24816252 GOT2 29138085 0 HMDB0000122 19 25.30103 TWO-HOUR GLUCOSE GLUCOSE TOLERANCE TEST HMDB0000122 rs1800437 19 45678134 Chen J et al,34059833 GPI 11318654 0 HMDB0000123 13 7.522878745 GLYCINE LEVELS GLYCINE MEASUREMENT HMDB0000123 rs9514191 13 103867788 Wittemans LBL et al,30837465 GPR18 4613056 0 HMDB0001349 5 38.69897 BLOOD AND TOENAIL SELENIUM LEVELS SELENIUM MEASUREMENT HMDB0001349 rs921943 5 79020653 Cornelis MC et al,25343990 GPX3 71999938 0 HMDB0000123 19 8.397940009 GLYCINE LEVELS GLYCINE MEASUREMENT HMDB0000123 rs273510 19 18112540 Wittemans LBL et al,30837465 GRIN3B 17112121 0 HMDB0001893 11 11.52287875 RESPONSE TO VITAMIN E SUPPLEMENTATION (ALPHA-TOH) RESPONSE TO VITAMIN HMDB0001893 rs964184 11 116778201 Major JM et al,22437554 GSTP1 49194459 0 HMDB0001013 7 8.301029996 COTININE GLUCURONIDATION COTININE GLUCURONIDATION MEASUREMENT HMDB0001013 rs6952407 7 66580525 Patel YM et al,25293881 GUSB 619841 0 HMDB0000301|HMDB0062562 12 26.09691001 SERUM METABOLITE LEVELS (TRANS-UROCANATE) SERUM METABOLITE MEASUREMENT HMDB0000301|HMDB0062562 rs11454735 12 95978249 Feofanova EV et al,33031748 HAL 5587 0 HMDB0000177 12 17.15490196 SERUM METABOLITE LEVELS (CMS) (HIS) SERUM METABOLITE MEASUREMENT HMDB0000177 rs4762254 12 95936803 Gallois A et al,31636271 HAL 35859 1 HMDB0000177 5 25.69897 URINARY METABOLITES (HISTIDINE/Τ-METHYLHISTIDINE) URINARY METABOLITE MEASUREMENT HMDB0000177 rs11133665 5 1188170 Raffler J et al,26352407 HARS2 139503260 0 HMDB0000122 5 33.69897 FASTING GLUCOSE GLUCOSE MEASUREMENT HMDB0000122 rs1820176 5 96360881 Chen J et al,34059833 HK3 80519988 0 HMDB0015531 22 300 IRON STATUS BIOMARKERS (IRON LEVELS) SERUM IRON MEASUREMENT HMDB0015531 rs855791 22 37066896 Bell S et al,33536631 HMOX1 1686535 0 HMDB0000054 22 40.30103 TOTAL BILIRUBIN LEVELS BILIRUBIN MEASUREMENT HMDB0000054 rs855791 22 37066896 Sakaue S et al,34594039 HMOX1 1686535 1 HMDB0000707 12 18.69897 SERUM METABOLITE LEVELS (4-HYDROXYPHENYLPYRUVATE) SERUM METABOLITE MEASUREMENT HMDB0000707 rs1720067 12 121925875 Feofanova EV et al,33031748 HPD 86348 0 HMDB0000669 12 10.69897 SERUM METABOLITE LEVELS (2-HYDROXYPHENYLACETATE) SERUM METABOLITE MEASUREMENT HMDB0000669 rs11614623 12 121864680 Feofanova EV et al,33031748 HPD 25153 1 HMDB0000234 16 85.09691001 TOTAL TESTOSTERONE LEVELS TESTOSTERONE MEASUREMENT HMDB0000234 rs58072681 16 81556936 Ruth KS et al,32042192 HSD17B2 478068 0 HMDB0000234 9 37.52287875 BIOAVAILABLE TESTOSTERONE LEVELS TESTOSTERONE MEASUREMENT HMDB0000234 rs912202 9 74610687 Ruth KS et al,32042192 HSD17B3 21624619 0 HMDB0000586 5 11.52287875 URINARY POTASSIUM EXCRETION (EA) POTASSIUM MEASUREMENT HMDB0000586 rs72704791 5 547781 Pazoki R et al,31409800 KCNIP1 169805706 0 HMDB0004246 4 47.39794001 BLOOD METABOLITE LEVELS (BRADYKININ, DES-ARG(9)) BLOOD METABOLITE MEASUREMENT HMDB0004246 rs4253311 4 186253529 Shin SY et al,24816252 KLKB1 44550 0 ~HMDB0000684 2 118.30103 SERUM METABOLITE LEVELS (N-ACETYLKYNURENINE (2)) SERUM METABOLITE MEASUREMENT ~HMDB0000684 rs10189885 2 73649928 Feofanova EV et al,33031748 KYNU 69227729 0 HMDB0059655 14 10.69897 SERUM METABOLITE LEVELS (2-HYDROXYGLUTARATE) SERUM METABOLITE MEASUREMENT HMDB0059655 rs8019274 14 50283206 Feofanova EV et al,33031748 L2HGDH 45643 0 HMDB0000122 12 28.69897 BLOOD GLUCOSE LEVELS GLUCOSE MEASUREMENT HMDB0000122 rs76895963 12 4275678 Sinnott-Armstrong N et al,33462484 LALBA 44292006 0 HMDB0000687 3 7.698970004 PLASMA FREE AMINO ACID LEVELS (LEU) LEUCINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000687 rs117936590 3 161421071 Imaizumi A et al,30659259 LARS2 116032510 0 HMDB0000067 16 102.30103 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs2000999 16 72074194 Sinnott-Armstrong N et al,33462484 LCAT 4134444 0 HMDB0000186 2 17.04575749 URINARY METABOLITE LEVELS IN CHRONIC KIDNEY DISEASE (LACTOSE) URINARY METABOLITE MEASUREMENT HMDB0000186 rs12465802 2 135623778 Schlosser P et al,31959995 LCT 164072 0 ~HMDB0005384 15 114.69897 TRIGLYCERIDE LEVELS TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs139974673 15 43735687 Richardson TG et al,32203549 LIPC 14674882 0 ~HMDB0005384 18 14.39794001 TRIGLYCERIDE LEVELS TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs7239575 18 23540071 Richardson TG et al,32203549 LIPG 26020628 0 ~HMDB0005384 3 34.52287875 TRIGLYCERIDE LEVELS TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs684773 3 136237463 Richardson TG et al,32203549 MGLL 8548401 0 HMDB0000161|HMDB0001310 18 7.522878745 PLASMA FREE AMINO ACID LEVELS (ALA) ALANINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000161|HMDB0001310 rs588682 18 3558080 Imaizumi A et al,30659259 MOCOS 32629417 0 HMDB0011578 11 61.09691001 SERUM METABOLITE LEVELS (1-ARACHIDONYLGLYCEROL (20:4)) SERUM METABOLITE MEASUREMENT HMDB0011578 rs102274 11 61790354 Feofanova EV et al,33031748 MOGAT2 13927484 0 HMDB0000207 11 39 OLEIC ACID (18:1N-9) LEVELS OLEIC ACID MEASUREMENT HMDB0000207 rs102275 11 61790331 Hu Y et al,28298293 MOGAT2 13927507 1 HMDB0011568 11 10.52287875 BLOOD METABOLITE LEVELS (1-LINOLEOYLGLYCEROL (1-MONOLINOLEIN)) BLOOD METABOLITE MEASUREMENT HMDB0011568 rs11825181 11 116755542 Shin SY et al,24816252 MOGAT2 41037704 1 ~HMDB0005384 7 358.5228787 TRIGLYCERIDES TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs55747707 7 73623036 Sakaue S et al,34594039 MOGAT3 27571971 0 HMDB0002005 8 11.52287875 SERUM METABOLITE LEVELS (METHIONINE SULFOXIDE) SERUM METABOLITE MEASUREMENT HMDB0002005 rs3750314 8 10428300 Feofanova EV et al,33031748 MSRA 374008 0 HMDB0000696 8 7.698970004 METABOLITE LEVELS (METHIONINE) METHIONINE MEASUREMENT HMDB0000696 rs145273360 8 62339883 Chai JF et al,31628463 MSRA 52285591 1 ~HMDB0005384 4 65.22184875 TRIGLYCERIDES TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs3775228 4 87064014 Sakaue S et al,34594039 MTTP 12500067 0 HMDB0001072 18 8 COENZYME Q10 LEVELS COENZYME Q10 MEASUREMENT HMDB0001072 rs9952641 18 318040 Degenhardt F et al,27149984 NDUFV2 8784590 0 HMDB0000230 1 17.69897 SERUM METABOLITE LEVELS (N-ACETYLNEURAMINATE) SERUM METABOLITE MEASUREMENT HMDB0000230 rs16859679 1 182806502 Feofanova EV et al,33031748 NPL 17209 0 HMDB0000151 3 7.522878745 ESTRADIOL LEVELS ESTRADIOL MEASUREMENT HMDB0000151 rs57102816 3 164788459 Schmitz D et al,34255042 NR1I2 45007975 0 HMDB0000299 6 13.52287875 METABOLITE LEVELS (XANTHOSINE) XANTHOSINE MEASUREMENT HMDB0000299 rs9477074 6 16269132 Rhee EP et al,23823483 NT5E 69180452 0 HMDB0000195 6 13.04575749 SERUM METABOLITE LEVELS (INOSINE) SERUM METABOLITE MEASUREMENT HMDB0000195 rs9353309 6 85416427 Feofanova EV et al,33031748 NT5E 33157 1 HMDB0000517|HMDB0000214 2 13.69897 BLOOD METABOLITE LEVELS (ARGININE / ORNITHINE) BLOOD METABOLITE MEASUREMENT HMDB0000517|HMDB0000214 rs6546838 2 73452153 Burkhardt R et al,26401656 ODC1 63012185 0 HMDB0000214 2 8.522878745 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR ONE OTHER PFAA) (ORN (ADJUSTED FOR GLY)) AMINO ACID MEASUREMENT HMDB0000214 rs12613336 2 210704675 Imaizumi A et al,30659259 ODC1 200264707 1 HMDB0000044 16 9.096910013 VITAMIN C LEVELS VITAMIN C MEASUREMENT HMDB0000044 rs56738967 16 79706644 Zheng JS et al,33203707 OGFOD1 23255123 0 HMDB0003229 10 16.52287875 SERUM METABOLITE LEVELS (PALMITOLEATE (16:1N7)) SERUM METABOLITE MEASUREMENT HMDB0003229 rs603424 10 100315722 Feofanova EV et al,33031748 OLAH 85283495 0 HMDB0000267 8 109.2218487 BLOOD METABOLITE LEVELS (5-OXOPROLINE) BLOOD METABOLITE MEASUREMENT HMDB0000267 rs12550729 8 144100505 Shin SY et al,24816252 OPLAH 49239 0 HMDB0013929|HMDB0005011 3 10.52287875 CLOPIDOGREL ACTIVE METABOLITE LEVELS CLOPIDOGREL METABOLITE MEASUREMENT HMDB0013929|HMDB0005011 rs187941554 3 8945549 Backman JD et al,28207573 P2RY12 142391294 0 ~HMDB0005384 17 125.69897 TRIGLYCERIDE LEVELS TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs72836561 17 43848758 Richardson TG et al,32203549 P4HB 37994401 0 HMDB0000044 17 14 VITAMIN C LEVELS VITAMIN C MEASUREMENT HMDB0000044 rs9895661 17 61379228 Zheng JS et al,33203707 P4HB 20463931 1 HMDB0010395|HMDB0010396 11 174.69897 GLYCEROPHOSPHOLIPID LEVELS (LYSOPHOSPHATIDYLCHOLINE ACYL C20:4) GLYCEROPHOSPHOLIPID MEASUREMENT,BLOOD METABOLITE MEASUREMENT HMDB0010395|HMDB0010396 rs174547 11 61803311 Draisma HHM et al,26068415 PAFAH1B2 55340973 0 HMDB0010395 11 128.154902 SERUM METABOLITE LEVELS (1-ARACHIDONOYL-GPC (20:4N6)*) SERUM METABOLITE MEASUREMENT HMDB0010395 rs174562 11 61817672 Feofanova EV et al,33031748 PAFAH1B2 55326612 1 HMDB0010390 11 93.69897 BLOOD METABOLITE LEVELS (1-ARACHIDONOYLGLYCEROPHOSPHOCHOLINE) BLOOD METABOLITE MEASUREMENT HMDB0010390 rs174535 11 61783884 Shin SY et al,24816252 PAFAH1B2 55360400 1 HMDB0010393|HMDB0010394|HMDB0010395|HMDB0010396 11 74.69897 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C20:3/LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C20:4) SERUM METABOLITE MEASUREMENT HMDB0010393|HMDB0010394|HMDB0010395|HMDB0010396 rs102275 11 61790331 Li Y et al,29545352 PAFAH1B2 55353953 1 HMDB0010394|HMDB0010395 11 69.69897 FATTY ACID DESATURASE ACTIVITY (SERUM) (D5D) FATTY ACID DESATURASE ENZYME ACTIVITY MEASUREMENT HMDB0010394|HMDB0010395 rs174549 11 61803910 Marklund M et al,30453627 PAFAH1B2 55340374 1 HMDB0010385|HMDB0010395|HMDB0010396 11 43.52287875 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C18:1/LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C20:4) SERUM METABOLITE MEASUREMENT HMDB0010385|HMDB0010395|HMDB0010396 rs174566 11 61824890 Li Y et al,29545352 PAFAH1B2 55319394 1 HMDB0010382|HMDB0240262|HMDB0010395|HMDB0010396 11 41.69897 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C16:0/LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C20:4) SERUM METABOLITE MEASUREMENT HMDB0010382|HMDB0240262|HMDB0010395|HMDB0010396 rs174564 11 61820833 Li Y et al,29545352 PAFAH1B2 55323451 1 HMDB0010383|HMDB0010395|HMDB0010396 11 35.09691001 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C16:1/LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C20:4) SERUM METABOLITE MEASUREMENT HMDB0010383|HMDB0010395|HMDB0010396 rs11320420 11 61774535 Li Y et al,29545352 PAFAH1B2 55369749 1 HMDB0010397 11 22.69897 METABOLITE LEVELS (LPC 20:5) LYSOPHOSPHATIDYLCHOLINE 20:5 MEASUREMENT HMDB0010397 rs174548 11 61803876 Rhee EP et al,23823483 PAFAH1B2 55340408 1 HMDB0010393|HMDB0010394 11 18.52287875 BLOOD METABOLITE LEVELS (1-EICOSATRIENOYLGLYCEROPHOSPHOCHOLINE) BLOOD METABOLITE MEASUREMENT HMDB0010393|HMDB0010394 rs968567 11 61828092 Shin SY et al,24816252 PAFAH1B2 55316192 1 HMDB0010407 11 18 SERUM METABOLITE LEVELS (1-(1-ENYL-PALMITOYL)-GPC (P-16:0)*) SERUM METABOLITE MEASUREMENT HMDB0010407 rs174560 11 61814292 Feofanova EV et al,33031748 PAFAH1B2 55329992 1 HMDB0010386 11 16.04575749 SERUM METABOLITE LEVELS (1-LINOLEOYL-GPC (18:2)) SERUM METABOLITE MEASUREMENT HMDB0010386 rs3834458 11 61827449 Feofanova EV et al,33031748 PAFAH1B2 55316835 1 HMDB0010404 11 13 METABOLITE LEVELS (LPC 22:6) LYSOPHOSPHATIDYLCHOLINE 22:6 MEASUREMENT HMDB0010404 rs174550 11 61804006 Rhee EP et al,23823483 PAFAH1B2 55340278 1 HMDB0010384 11 10.15490196 SERUM METABOLITE LEVELS (1-STEAROYL-GPC (18:0)) SERUM METABOLITE MEASUREMENT HMDB0010384 rs174560 11 61814292 Feofanova EV et al,33031748 PAFAH1B2 55329992 1 HMDB0010394 11 9.397940009 METABOLITE LEVELS (LPC 20:3) LYSOPHOSPHATIDYLCHOLINE 20:3 MEASUREMENT HMDB0010394 rs968567 11 61828092 Rhee EP et al,23823483 PAFAH1B2 55316192 1 HMDB0000159 12 24.52287875 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR TWENTY OTHER PFAAS) (PHE) PHENYLALANINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000159 rs17450122 12 102960616 Imaizumi A et al,30659259 PAH 123727 0 HMDB0002172 10 29.09691001 SERUM METABOLITE LEVELS (N1,N12-DIACETYLSPERMINE) SERUM METABOLITE MEASUREMENT HMDB0002172 rs4240520 10 133383915 Feofanova EV et al,33031748 PAOX 4654 0 HMDB0001276 10 16 SERUM METABOLITE LEVELS (N('1)-ACETYLSPERMIDINE) SERUM METABOLITE MEASUREMENT HMDB0001276 rs11101731 10 133383872 Feofanova EV et al,33031748 PAOX 4611 1 HMDB0001830 11 11.09691001 SEX HORMONE LEVELS (PROGESTERONE) HORMONE MEASUREMENT,PROGESTERONE MEASUREMENT HMDB0001830 rs112295236 11 63147874 Ruth KS et al,26014426 PGR 37881750 0 HMDB0000586 15 23.30103 POTASSIUM LEVELS POTASSIUM MEASUREMENT HMDB0000586 rs1290083 15 50858717 Kanai M et al,29403010 PKM 21340312 0 HMDB0000673|HMDB0005060 16 31.30103 BLOOD METABOLITE RATIOS (LINOLEATE (18:2N6)/DIHOMO-LINOLENATE (20:3N3 OR N6)) BLOOD METABOLITE MEASUREMENT HMDB0000673|HMDB0005060 rs2740 16 15038251 Shin SY et al,24816252 PLA2G10 365703 0 ~HMDB0000673 16 24.30103 PLASMA OMEGA-6 POLYUNSATURATED FATTY ACID LEVELS (DIHOMO-GAMMA-LINOLENIC ACID) (CONDITIONED ON RS16966952) OMEGA-6 POLYUNSATURATED FATTY ACID MEASUREMENT ~HMDB0000673 rs2280018 16 15056976 Guan W et al,24823311 PLA2G10 384428 1 HMDB0000673 16 14.30103 LIPID METABOLISM PHENOTYPES (LA/PUFA) LIPID MEASUREMENT HMDB0000673 rs11075253 16 15054789 Kettunen J et al,22286219 PLA2G10 382241 1 HMDB0003073|HMDB0000673 16 7.301029996 FATTY ACID DESATURASE ACTIVITY (SERUM) (D6D) FATTY ACID DESATURASE ENZYME ACTIVITY MEASUREMENT HMDB0003073|HMDB0000673 rs6498540 16 15036737 Marklund M et al,30453627 PLA2G10 364189 1 HMDB0010383 10 18.04575749 GLYCEROPHOSPHOLIPID LEVELS (LYSOPHOSPHATIDYLCHOLINE ACYL C16:1) GLYCEROPHOSPHOLIPID MEASUREMENT,BLOOD METABOLITE MEASUREMENT HMDB0010383 rs603424 10 100315722 Draisma HHM et al,26068415 PLA2G12B 27380960 0 HMDB0010382|HMDB0240262|HMDB0010383 10 12.52287875 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C16:0/LYSOPHOSPHATIDYLCHOLINE WITH ACYL RESIDUE C16:1) SERUM METABOLITE MEASUREMENT HMDB0010382|HMDB0240262|HMDB0010383 rs603424 10 100315722 Li Y et al,29545352 PLA2G12B 27380960 1 HMDB0001388 10 7.397940009 PLASMA OMEGA-3 POLYUNSATURATED FATTY ACID LEVELS (ALPHALINOLENIC ACID) ALPHA-LINOLENIC ACID MEASUREMENT HMDB0001388 rs7903338 10 97799964 Dorajoo R et al,26584805 PLA2G12B 24865202 1 HMDB0001388 12 29.52287875 RED BLOOD CELL FATTY ACID LEVELS (LA) FATTY ACID MEASUREMENT,LINOLEIC ACID MEASUREMENT HMDB0001388 rs12580543 12 6992881 Tintle NL et al,25500335 PLA2G1B 113329234 0 ~HMDB0010407 15 12.04575749 METABOLITE LEVELS (GLYCEROPHOSPHO-N-PALMITOYL ETHANOLAMINE) METABOLITE MEASUREMENT ~HMDB0010407 rs261342 15 58438954 Hong MG et al,23281178 PLA2G4B 16601179 0 ~HMDB0010396 6 7.522878745 LYSOPHOSPHATIDYLCHOLINE LEVELS (TOTAL_LPC) LYSOPHOSPHATIDYLCHOLINE MEASUREMENT ~HMDB0010396 rs543895501 6 73410627 Tabassum R et al,31551469 PLA2G7 26706426 0 HMDB0008134 2 7.522878745 METABOLITE LEVELS (PC 34:3) PHOSPHATIDYLCHOLINE 34:3 MEASUREMENT HMDB0008134 rs1260326 2 27508073 Rhee EP et al,23823483 PLB1 949072 0 HMDB0007906 2 7.397940009 METABOLITE LEVELS (PC 32:2) PHOSPHATIDYLCHOLINE 32:2 MEASUREMENT HMDB0007906 rs1260326 2 27508073 Rhee EP et al,23823483 PLB1 949072 1 HMDB0011206 14 84.39794001 SERUM METABOLITE LEVELS (1-(1-ENYL-PALMITOYL)-2-PALMITOYL-GPC (P-16:0/16:0)*) SERUM METABOLITE MEASUREMENT HMDB0011206 rs1077989 14 67509105 Feofanova EV et al,33031748 PLD4 37415608 0 HMDB0011207 14 65.22184875 SERUM METABOLITE LEVELS (1-(1-ENYL-PALMITOYL)-2-PALMITOLEOYL-GPC (P-16:0/16:1)*) SERUM METABOLITE MEASUREMENT HMDB0011207 rs1077989 14 67509105 Feofanova EV et al,33031748 PLD4 37415608 1 ~HMDB0007867 14 62.39794001 GLYCEROPHOSPHOLIPID LEVELS (PHOSPHATIDYLCHOLINE DIACYL C28:1) GLYCEROPHOSPHOLIPID MEASUREMENT,BLOOD METABOLITE MEASUREMENT ~HMDB0007867 rs7157785 14 63768838 Draisma HHM et al,26068415 PLD4 41155875 1 ~HMDB0008027 14 56.04575749 GLYCEROPHOSPHOLIPID LEVELS (PHOSPHATIDYLCHOLINE ACYL-ALKYL C32:1) GLYCEROPHOSPHOLIPID MEASUREMENT,BLOOD METABOLITE MEASUREMENT ~HMDB0008027 rs1077989 14 67509105 Draisma HHM et al,26068415 PLD4 37415608 1 ~HMDB0011303 14 45 GLYCEROPHOSPHOLIPID LEVELS (PHOSPHATIDYLCHOLINE ACYL-ALKYL C32:2) GLYCEROPHOSPHOLIPID MEASUREMENT,BLOOD METABOLITE MEASUREMENT ~HMDB0011303 rs1077989 14 67509105 Draisma HHM et al,26068415 PLD4 37415608 1 ~HMDB0011313 14 39.22184875 GLYCEROPHOSPHOLIPID LEVELS (PHOSPHATIDYLCHOLINE ACYL-ALKYL C36:5) GLYCEROPHOSPHOLIPID MEASUREMENT,BLOOD METABOLITE MEASUREMENT ~HMDB0011313 rs1077989 14 67509105 Draisma HHM et al,26068415 PLD4 37415608 1 HMDB0011220|HMDB0011221 14 29.52287875 SERUM METABOLITE LEVELS (1-(1-ENYL-PALMITOYL)-2-ARACHIDONOYL-GPC (P-16:0/20:4)*) SERUM METABOLITE MEASUREMENT HMDB0011220|HMDB0011221 rs1077989 14 67509105 Feofanova EV et al,33031748 PLD4 37415608 1 ~HMDB0008027|~HMDB0011209 14 29.30103 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C32:1/PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C34:1) SERUM METABOLITE MEASUREMENT ~HMDB0008027|~HMDB0011209 rs1885041 14 67509608 Li Y et al,29545352 PLD4 37415105 1 ~HMDB0000564|~HMDB0008027 14 21.30103 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (PHOSPHATIDYLCHOLINE WITH DIACYL RESIDUE SUM C32:0/PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C32:1) SERUM METABOLITE MEASUREMENT ~HMDB0000564|~HMDB0008027 rs1885041 14 67509608 Li Y et al,29545352 PLD4 37415105 1 ~HMDB0011313|~HMDB0011255 14 20.39794001 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C36:5/PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C38:5) SERUM METABOLITE MEASUREMENT ~HMDB0011313|~HMDB0011255 rs72719193 14 67502391 Li Y et al,29545352 PLD4 37422322 1 ~HMDB0011311|~HMDB0011313 14 19.69897 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C36:4/PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C36:5) SERUM METABOLITE MEASUREMENT ~HMDB0011311|~HMDB0011313 rs1077989 14 67509105 Li Y et al,29545352 PLD4 37415608 1 ~HMDB0011303|~HMDB0011209 14 15.52287875 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C32:2/PHOSPHATIDYLCHOLINE WITH ACYL-ALKYL RESIDUE SUM C34:1) SERUM METABOLITE MEASUREMENT ~HMDB0011303|~HMDB0011209 rs72719193 14 67502391 Li Y et al,29545352 PLD4 37422322 1 HMDB0011209|HMDB0011210 14 13.69897 SERUM METABOLITE LEVELS (1-(1-ENYL-PALMITOYL)-2-OLEOYL-GPC (P-16:0/18:1)*) SERUM METABOLITE MEASUREMENT HMDB0011209|HMDB0011210 rs1077989 14 67509105 Feofanova EV et al,33031748 PLD4 37415608 1 ~HMDB0004971 7 7.522878745 METABOLITE LEVELS (HEXCER D18:1/16:0) SPHINGOLIPID MEASUREMENT ~HMDB0004971 rs185912594 7 18316310 Chai JF et al,31628463 PLEKHA8 11711094 0 ~HMDB0000450 1 25.69897 URINARY METABOLITE MODULES (EIGENMETABOLITES) IN CHRONIC KIDNEY DISEASE (4-HYDROXYGLUTAMATE, 5-HYDROXYLYSINE, X-24462) URINARY METABOLITE MEASUREMENT ~HMDB0000450 rs1043657 1 19308517 Schlosser P et al,31959995 PLOD1 7374312 0 HMDB0000133 14 15.22184875 GUANOSINE LEVELS METABOLITE MEASUREMENT HMDB0000133 rs1760940 14 20470092 Panyard DJ et al,33437055 PNP 1138 0 ~HMDB0005384 X 35.69897 TRIGLYCERIDES TRIGLYCERIDE MEASUREMENT ~HMDB0005384 rs5942951 X 110514753 Sakaue S et al,34594039 PNPLA4 102616506 0 HMDB0001999 6 11.69897 PLASMA OMEGA-3 POLYUNSATURATED FATTY ACID LEVEL (EICOSAPENTAENOIC ACID) EICOSAPENTAENOIC ACID MEASUREMENT HMDB0001999 rs3798713 6 11008389 Lemaitre RN et al,21829377 PPARD 24334169 0 HMDB0000162|HMDB0003411 22 69 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR TWENTY OTHER PFAAS) (PRO) PROLINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000162|HMDB0003411 rs2238732 22 18927834 Imaizumi A et al,30659259 PRODH 15057 0 HMDB0000187 7 25 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR TWENTY OTHER PFAAS) (SER) SERINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000187 rs2242508 7 56083796 Imaizumi A et al,30659259 PSPH 72745 0 HMDB0000289 14 16 SERUM URIC ACID LEVELS URIC ACID MEASUREMENT HMDB0000289 rs72681869 14 50188639 Sakaue S et al,34594039 PYGL 669252 0 HMDB0011745 3 12.30103 SERUM METABOLITE CONCENTRATIONS IN CHRONIC KIDNEY DISEASE (N-ACETYLMETHIONINE) SERUM METABOLITE MEASUREMENT HMDB0011745 rs73835707 3 52120872 Luo S et al,33838163 RHO 77407767 0 HMDB0000271 9 21.22184875 SERUM METABOLITE LEVELS (SARCOSINE) SERUM METABOLITE MEASUREMENT HMDB0000271 rs111389997 9 133736647 Feofanova EV et al,33031748 SARDH 73087 0 HMDB0000248 X 20 METABOLITE LEVELS (THYROXINE) THYROXINE MEASUREMENT HMDB0000248 rs7883218 X 106032618 Rhee EP et al,23823483 SERPINA7 183 0 HMDB0000248|HMDB0000265 X 13 HYPOTHYROIDISM HYPOTHYROIDISM HMDB0000248|HMDB0000265 rs57033802 X 78973547 Sakaue S et al,34594039 SERPINA7 27058888 1 HMDB0011207 10 13.69897 SERUM METABOLITE LEVELS (1-(1-ENYL-PALMITOYL)-2-PALMITOLEOYL-GPC (P-16:0/16:1)*) SERUM METABOLITE MEASUREMENT HMDB0011207 rs603424 10 100315722 Feofanova EV et al,33031748 SGMS1 50010136 0 HMDB0000234 17 741.0457575 TOTAL TESTOSTERONE LEVELS TESTOSTERONE MEASUREMENT HMDB0000234 rs1799941 17 7630105 Ruth KS et al,32042192 SHBG 16159 0 HMDB0000234 14 95 TOTAL TESTOSTERONE LEVELS TESTOSTERONE MEASUREMENT HMDB0000234 rs28929474 14 94378610 Ruth KS et al,32042192 SLC10A1 24603194 0 HMDB0002497 13 11.39794001 SERUM METABOLITE LEVELS (GLYCODEOXYCHOLATE SULFATE) SERUM METABOLITE MEASUREMENT HMDB0002497 rs55971546 13 103065958 Feofanova EV et al,33031748 SLC10A2 21960 0 HMDB0000492 20 7.397940009 CHLORIDE LEVELS CHLORIDE MEASUREMENT HMDB0000492 rs459044 20 54062115 Kanai M et al,29403010 SLC12A5 8040425 0 HMDB0001448 7 9.045757491 SERUM SULFATE LEVEL SULFATE MEASUREMENT HMDB0001448 rs17684427 7 122842923 Tise CG et al,27412988 SLC13A4 12838308 0 HMDB0000172|HMDB0000687|HMDB0000824 6 25.69897 BLOOD METABOLITE LEVELS (LEUCINE|ISOLEUCINE / PROPIONYLCARNITINE) BLOOD METABOLITE MEASUREMENT HMDB0000172|HMDB0000687|HMDB0000824 rs12210538 6 110438805 Burkhardt R et al,26401656 SLC16A10 648698 0 HMDB0000172 6 12 METABOLIC TRAITS (ISOLEUCINE/TYROSINE + 10 OTHER TRAITS) METABOLITE MEASUREMENT HMDB0000172 rs7760535 6 111425880 Suhre K et al,21886157 SLC16A10 338377 1 HMDB0000929 6 11 BLOOD METABOLITE LEVELS (TRYPTOPHAN) BLOOD METABOLITE MEASUREMENT HMDB0000929 rs6901004 6 111233619 Shin SY et al,24816252 SLC16A10 146116 1 HMDB0000172|HMDB0000687|HMDB0000688 6 7.301029996 BLOOD METABOLITE LEVELS (ISOVALERYLCARNITINE / LEUCINE|ISOLEUCINE) BLOOD METABOLITE MEASUREMENT HMDB0000172|HMDB0000687|HMDB0000688 rs12210538 6 110438805 Burkhardt R et al,26401656 SLC16A10 648698 1 HMDB0000167 2 12.09691001 SERUM METABOLITE LEVELS (THREONINE) SERUM METABOLITE MEASUREMENT HMDB0000167 rs1260326 2 27508073 Feofanova EV et al,33031748 SLC1A4 37480404 0 HMDB0000062 6 24.22184875 BLOOD METABOLITE LEVELS (CARNITINE FREE) BLOOD METABOLITE MEASUREMENT HMDB0000062 rs12210538 6 110438805 Burkhardt R et al,26401656 SLC22A16 14118 0 HMDB0003045 5 13.69897 SERUM METABOLITE LEVELS (ERGOTHIONEINE) SERUM METABOLITE MEASUREMENT HMDB0003045 rs2631363 5 132371403 Feofanova EV et al,33031748 SLC22A4 77009 0 HMDB0000062 3 11.39794001 BLOOD METABOLITE LEVELS (CARNITINE) BLOOD METABOLITE MEASUREMENT HMDB0000062 rs9842133 3 179946314 Shin SY et al,24816252 SLC25A20 131089388 0 HMDB0002259 5 8 CIRCULATING ODD-NUMBERED CHAIN SATURATED FATTY ACID LEVELS (C17:0) FATTY ACID MEASUREMENT HMDB0002259 rs13361131 5 16804871 de Oliveira Otto MC et al,29738550 SLC27A6 111733142 0 HMDB0000092|HMDB0000161|HMDB0001310 3 59.09691001 URINARY METABOLITES (N,N-DIMETHYLGLYCINE/ALANINE) URINARY METABOLITE MEASUREMENT HMDB0000092|HMDB0000161|HMDB0001310 rs17279437 3 45772602 Raffler J et al,26352407 SLC38A3 4432644 0 HMDB0000161|HMDB0001310|HMDB0000092 3 18.52287875 URINARY METABOLITES (ALANINE/N,N-DIMETHYLGLYCINE RATIO) METABOLITE MEASUREMENT HMDB0000161|HMDB0001310|HMDB0000092 rs17279437 3 45772602 Suhre K et al,21572414 SLC38A3 4432644 1 HMDB0000248|HMDB0000265 11 30.69897 HYPOTHYROIDISM HYPOTHYROIDISM HMDB0000248|HMDB0000265 rs4409785 11 95578258 Kichaev G et al,30595370 SLC3A2 32722254 0 HMDB0000248 11 10.09691001 FREE THYROXINE CONCENTRATION THYROXINE MEASUREMENT HMDB0000248 rs11039355 11 47715949 Teumer A et al,30367059 SLC3A2 15140055 1 HMDB0000043|HMDB0062558 12 27 BLOOD METABOLITE RATIOS (BETAINE/PYROGLUTAMINE) BLOOD METABOLITE MEASUREMENT HMDB0000043|HMDB0062558 rs7969761 12 246676 Shin SY et al,24816252 SLC6A12 56599 0 HMDB0000043 12 12.09691001 BLOOD METABOLITE LEVELS (BETAINE) BLOOD METABOLITE MEASUREMENT HMDB0000043 rs499368 12 211754 Shin SY et al,24816252 SLC6A12 21677 1 HMDB0000123 1 18.09691001 GLYCINE LEVELS GLYCINE MEASUREMENT HMDB0000123 rs4646961 1 75751484 Wittemans LBL et al,30837465 SLC6A9 31759984 0 HMDB0000214 22 8.301029996 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR ONE OTHER PFAA) (ORN (ADJUSTED FOR PRO)) AMINO ACID MEASUREMENT HMDB0000214 rs2238732 22 18927834 Imaizumi A et al,30659259 SLC7A4 2100884 0 HMDB0000161|HMDB0001310 14 7.698970004 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR ONE OTHER PFAA) (ALA (ADJUSTED FOR ASN)) ALANINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000161|HMDB0001310 rs1744297 14 104102135 Imaizumi A et al,30659259 SLC7A8 80976840 0 HMDB0000159 14 7.301029996 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR ONE OTHER PFAA) (PHE (ADJUSTED FOR ASN)) PHENYLALANINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000159 rs1744297 14 104102135 Imaizumi A et al,30659259 SLC7A8 80976840 1 HMDB0000054 12 675.09691 TOTAL BILIRUBIN LEVELS BILIRUBIN MEASUREMENT HMDB0000054 rs4149081 12 21225087 Sinnott-Armstrong N et al,33462484 SLCO1B1 93893 0 HMDB0000378|HMDB0000688|HMDB0000062 12 32.69897 SERUM METABOLITE RATIOS IN CHRONIC KIDNEY DISEASE (CARNITINE (FREE)/BUTYRYLCARNITINE / ISOBUTYRYLCARNITINE) SERUM METABOLITE MEASUREMENT HMDB0000378|HMDB0000688|HMDB0000062 rs1799958 12 120738280 Li Y et al,29545352 SLCO1B1 99607086 1 HMDB0000054|HMDB0000488 12 13 SERUM METABOLITE LEVELS (BILIRUBIN (E,Z OR Z,E)*) SERUM METABOLITE MEASUREMENT HMDB0000054|HMDB0000488 rs4149056 12 21178615 Feofanova EV et al,33031748 SLCO1B1 47421 1 HMDB0004953 11 9.698970004 METABOLITE LEVELS (CER D18:1/24:1) CERAMIDE MEASUREMENT HMDB0004953 rs72643557 11 61811955 Chai JF et al,31628463 SMPD1 55421515 0 ~HMDB0004953 11 8.522878745 METABOLITE LEVELS (CER D18:2/26:0) CERAMIDE MEASUREMENT ~HMDB0004953 rs11320420 11 61774535 Chai JF et al,31628463 SMPD1 55384095 1 ~HMDB0004955 6 10 CERAMIDE LEVELS (N26S19) CERAMIDE MEASUREMENT ~HMDB0004955 rs6940658 6 14238280 McGurk KA et al,33437986 SMPD2 95202444 0 ~HMDB0012102 6 10 SERUM METABOLITE CONCENTRATIONS IN CHRONIC KIDNEY DISEASE (SPHINGOMYELIN (D18:1/20:1, D18:2/20:0)) SERUM METABOLITE MEASUREMENT ~HMDB0012102 rs60132035 6 125764108 Luo S et al,33838163 SMPD2 16323384 1 HMDB0000067 12 54.69897 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs2244608 12 120979185 Sinnott-Armstrong N et al,33462484 SOAT2 67875699 0 HMDB0000187 14 11 PLASMA FREE AMINO ACID LEVELS (ADJUSTED FOR ONE OTHER PFAA) (SER (ADJUSTED FOR ASN)) SERINE MEASUREMENT,AMINO ACID MEASUREMENT HMDB0000187 rs1744297 14 104102135 Imaizumi A et al,30659259 SPTLC2 26596138 0 HMDB0000067 X 29.09691001 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs5942937 X 110473179 Hoffmann TJ et al,29507422 STS 103325942 0 HMDB0001032 X 8.096910013 DHEAS LEVELS DEHYDROEPIANDROSTERONE SULPHATE MEASUREMENT HMDB0001032 rs5935876 X 7004037 Pott J et al,31169883 STS 143200 1 HMDB0000067 19 2357.69897 TOTAL CHOLESTEROL LEVELS TOTAL CHOLESTEROL MEASUREMENT HMDB0000067 rs7412 19 44908822 Sinnott-Armstrong N et al,33462484 SULT2B1 3643350 0 @any|HMDB0000067 19 22.30103 BLOOD METABOLITE RATIOS (X-11820/CHOLESTEROL) BLOOD METABOLITE MEASUREMENT @any|HMDB0000067 rs445925 19 44912383 Shin SY et al,24816252 SULT2B1 3639789 1 HMDB0001032 19 18.52287875 DEHYDROEPIANDROSTERONE SULPHATE LEVELS HORMONE MEASUREMENT HMDB0001032 rs2637125 19 47898636 Zhai G et al,21533175 SULT2B1 653536 1 HMDB0002759 19 11.22184875 BLOOD METABOLITE LEVELS (ANDROSTERONE SULFATE) BLOOD METABOLITE MEASUREMENT HMDB0002759 rs182420 19 47868938 Shin SY et al,24816252 SULT2B1 683234 1 HMDB0002174 11 14.52287875 VITAMIN B12 LEVELS VITAMIN B12 MEASUREMENT HMDB0002174 rs2298585 11 60069719 Lin X et al,22367966 TCN1 216919 0 HMDB0000929 4 11.04575749 BLOOD METABOLITE LEVELS (TRYPTOPHAN) BLOOD METABOLITE MEASUREMENT HMDB0000929 rs13122250 4 155887136 Shin SY et al,24816252 TDO2 32398 0 HMDB0000248|HMDB0000265 17 15.04575749 HYPOTHYROIDISM HYPOTHYROIDISM HMDB0000248|HMDB0000265 rs11079786 17 47728550 Kichaev G et al,30595370 THRA 7670260 0 HMDB0000265 17 8.096910013 PROTEIN QUANTITATIVE TRAIT LOCI (FT3) TRIIODOTHYRONINE MEASUREMENT HMDB0000265 rs3848445 17 14390704 Melzer D et al,18464913 THRA 25667586 1 HMDB0000248|HMDB0000265 3 47.69897 HYPOTHYROIDISM HYPOTHYROIDISM HMDB0000248|HMDB0000265 rs12634152 3 188403231 Kichaev G et al,30595370 THRB 164286078 0 HMDB0060412 6 20 ERYTHROCYTE METHYLATED 6-MERCAPTOPURINE METABOLITE CONCENTRATION IN 6-MERCAPTOPURINE-TREATED ACUTE LYMPHOBLASTIC LEUKAEMIA THIOPURINE METABOLITE MEASUREMENT,RESPONSE TO MERCAPTOPURINE HMDB0060412 rs10949482 6 18121083 Tulstrup M et al,30201983 TPMT 7228 0 HMDB0000975 11 29.52287875 SERUM METABOLITE LEVELS (TREHALOSE) SERUM METABOLITE MEASUREMENT HMDB0000975 rs507080 11 118678873 Yu B et al,24625756 TREH 21557 0 HMDB0000248|HMDB0000265 18 12.69897 HYPOTHYROIDISM HYPOTHYROIDISM HMDB0000248|HMDB0000265 rs6505765 18 12782850 Kichaev G et al,30595370 TTR 18774159 0 HMDB0000248 18 9 FREE THYROXINE CONCENTRATION THYROXINE MEASUREMENT HMDB0000248 rs113107469 18 31726774 Taylor PN et al,25743335 TTR 169765 1 ~HMDB0000296 9 229.69897 SERUM METABOLITE LEVELS (2'-O-METHYLURIDINE) SERUM METABOLITE MEASUREMENT ~HMDB0000296 rs57294583 9 128922557 Feofanova EV et al,33031748 UCK1 2601244 0 HMDB0000008 2 9 METABOLITE LEVELS (ALPHA HYDROXYBUTYRIC ACID) ALPHA-HYDROXYBUTYRIC ACID MEASUREMENT HMDB0000008 rs1260326 2 27508073 Rhee EP et al,23823483 UGT1A1 206252197 0 HMDB0000226 3 162.0457575 SERUM METABOLITE LEVELS (OROTATE) SERUM METABOLITE MEASUREMENT HMDB0000226 rs3772806 3 124739486 Feofanova EV et al,33031748 UMPS 9053 0 HMDB0000026 22 18.52287875 SERUM METABOLITE LEVELS (3-UREIDOPROPIONATE) SERUM METABOLITE MEASUREMENT HMDB0000026 rs141327056 22 24510394 Feofanova EV et al,33031748 UPB1 16287 0 HMDB0000289 2 167 URATE LEVELS URATE MEASUREMENT HMDB0000289 rs1260326 2 27508073 Gill D et al,33356394 XDH 3826248 0