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{"sheet":"Filtered_reactions","index":0,"n_rows":378,"n_cols":7,"rows_kept":378,"cut":false,"hidden":false,"merged":[]}
["RXN_ID","SubSystem","ART","EC","HC","EQN","GENE"]
["HMR_3804","Alanine, aspartate and glutamate metabolism",1000,1000,-1000,"AKG[m] + 2 H+[m] + NADPH[m] + NH3[m] <=> glutamate[m] + H2O[m] + NADP+[m]","ENSG00000148672 or ENSG00000182890"]
["HMR_3831","Alanine, aspartate and glutamate metabolism",568.55240235,983.8703706637,"NA","aspartate[c] => fumarate[c] + H+[c] + NH3[c]","ENSG00000091483"]
["HMR_3829","Alanine, aspartate and glutamate metabolism",-251.8192574834,3.5596485863,787.3788571269,"AKG[c] + aspartate[c] <=> glutamate[c] + OAA[c]","ENSG00000120053 or ENSG00000169154"]
["HMR_3802","Alanine, aspartate and glutamate metabolism",-409.3892680481,"NA",834.9498407164,"AKG[m] + 2 H+[m] + NADH[m] + NH3[m] <=> glutamate[m] + H2O[m] + NAD+[m]","ENSG00000148672 or ENSG00000182890"]
["HMR_4300","Amino sugar and nucleotide sugar metabolism",61.75339325,"NA","NA","fructose-6-phosphate[c] + glutamine[c] => glucosamine-6-phosphate[c] + glutamate[c]","ENSG00000131459 or ENSG00000198380"]
["HMR_4299","Amino sugar and nucleotide sugar metabolism",61.75339325,"NA","NA","glucosamine-6-phosphate[c] + H2O[c] => fructose-6-phosphate[c] + H+[c] + NH3[c]","ENSG00000113552 or ENSG00000163281"]
["HMR_3956","Arginine and proline metabolism",327.9626769379,"NA","NA","CO2[m] + H2O[m] => H+[m] + HCO3-[m]","ENSG00000169239 or ENSG00000174990"]
["HMR_3142","Beta oxidation of even-chain fatty acids (mitochondrial)","NA",83.453446828,"NA","decanoyl-CoA[m] + FAD[m] => (2E)-decenoyl-CoA[m] + FADH2[m]","ENSG00000117054 or ENSG00000177646"]
["HMR_1614","Bile acid biosynthesis","NA","NA",958.4024025611,"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[m] + NADPH[m] + O2[m] => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[m] + H2O[m] + NADP+[m]","ENSG00000135929"]
["HMR_1604","Bile acid biosynthesis",104.3268690731,295.1429371045,"NA","5beta-cholestan-3alpha,7alpha,12alpha-triol[c] + H+[c] + NADPH[c] + O2[c] => 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[c] + H2O[c] + NADP+[c]","ENSG00000135929"]
["HMR_1608","Bile acid biosynthesis",104.3268690731,295.1429371045,"NA","5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[c] + NAD+[c] => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[c] + H+[c] + NADH[c]","ENSG00000135929"]
["HMR_1685","Bile acid biosynthesis",1000,"NA","NA","5beta-cholestane-3alpha,7alpha,26-triol[m] + NADP+[m] => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADPH[m]","ENSG00000135929"]
["RE2625M","Bile acid biosynthesis","NA","NA",-958.4024025611,"5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[m] + NAD+[m] <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al[m] + H+[m] + NADH[m]","ENSG00000135929"]
["HMR_1609","Bile acid biosynthesis","NA","NA",958.4024025611,"5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[m] + NAD+[m] => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADH[m]","ENSG00000135929"]
["HMR_1611","Bile acid biosynthesis",104.3268690731,295.1429371045,"NA","3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[c] + H2O[c] + NAD+[c] => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[c] + 2 H+[c] + NADH[c]","ENSG00000135929"]
["HMR_1806","Bile acid biosynthesis",104.3268690731,295.1429371045,"NA","3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al[m] + H+[m] + NADH[m] <=> 5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol[m] + NAD+[m]","ENSG00000135929"]
["HMR_1693","Bile acid biosynthesis","NA",178.26780852,"NA","3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + NADPH[m] + O2[m] => 3alpha,7alpha-dihydroxy-5beta-cholestanate[m] + H2O[m] + NADP+[m]","ENSG00000135929"]
["HMR_1802","Bile acid biosynthesis",-104.3268690731,-295.1429371045,"NA","5beta-cholestan-3alpha,7alpha,12alpha-triol[m] + H+[m] + NADPH[m] + O2[m] <=> 5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol[m] + H2O[m] + NADP+[m]","ENSG00000130649 or ENSG00000135929"]
["RE1804M","Bile acid biosynthesis",-1000,"NA","NA","5beta-cholestane-3alpha,7alpha,26-triol[m] + NAD+[m] <=> 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADH[m]","ENSG00000135929"]
["RE1807M","Bile acid biosynthesis","NA",-178.26780852,"NA","3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H2O[m] + NADP+[m] <=> 3alpha,7alpha-dihydroxy-5beta-cholestanate[m] + 2 H+[m] + NADPH[m]","ENSG00000135929"]
["HMR_1877","Bile acid recycling","NA",1000,1000,"GSH[c] + HCO3-[c] + taurocholate[s] <=> GSH[s] + HCO3-[s] + taurocholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1893","Bile acid recycling","NA",-1000,1000,"HCO3-[c] + S-glutathionyl-2-4-dinitrobenzene[c] + taurochenodeoxycholate[s] <=> HCO3-[s] + S-glutathionyl-2-4-dinitrobenzene[s] + taurochenodeoxycholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1876","Bile acid recycling","NA",-1000,-1000,"glycocholate[s] + GSH[c] + HCO3-[c] <=> glycocholate[c] + GSH[s] + HCO3-[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1892","Bile acid recycling","NA",-1000,-1000,"glutathionyl-leukotriene C4[c] + HCO3-[c] + taurochenodeoxycholate[s] <=> glutathionyl-leukotriene C4[s] + HCO3-[s] + taurochenodeoxycholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1888","Bile acid recycling","NA",-1000,"NA","chenodiol[s] + HCO3-[c] + S-glutathionyl-ethacrynic acid[c] <=> chenodiol[c] + HCO3-[s] + S-glutathionyl-ethacrynic acid[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1883","Bile acid recycling","NA","NA",-1000,"glutathionyl-leukotriene C4[c] + glycocholate[s] + HCO3-[c] <=> glutathionyl-leukotriene C4[s] + glycocholate[c] + HCO3-[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1881","Bile acid recycling","NA",1000,1000,"cholate[s] + HCO3-[c] + S-glutathionyl-2-4-dinitrobenzene[c] <=> cholate[c] + HCO3-[s] + S-glutathionyl-2-4-dinitrobenzene[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1882","Bile acid recycling","NA",1000,1000,"cholate[s] + HCO3-[c] + S-glutathionyl-ethacrynic acid[c] <=> cholate[c] + HCO3-[s] + S-glutathionyl-ethacrynic acid[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1887","Bile acid recycling","NA",1000,-1000,"chenodiol[s] + HCO3-[c] + S-glutathionyl-2-4-dinitrobenzene[c] <=> chenodiol[c] + HCO3-[s] + S-glutathionyl-2-4-dinitrobenzene[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1894","Bile acid recycling","NA",1000,-1000,"HCO3-[c] + S-glutathionyl-ethacrynic acid[c] + taurochenodeoxycholate[s] <=> HCO3-[s] + S-glutathionyl-ethacrynic acid[s] + taurochenodeoxycholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1890","Bile acid recycling","NA","NA",-1000,"HCO3-[c] + S-glutathionyl-2-4-dinitrobenzene[c] + taurocholate[s] <=> HCO3-[s] + S-glutathionyl-2-4-dinitrobenzene[s] + taurocholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1885","Bile acid recycling","NA",1000,1000,"glycocholate[s] + HCO3-[c] + S-glutathionyl-ethacrynic acid[c] <=> glycocholate[c] + HCO3-[s] + S-glutathionyl-ethacrynic acid[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1879","Bile acid recycling","NA",1000,986.9393815,"GSH[c] + HCO3-[c] + taurochenodeoxycholate[s] <=> GSH[s] + HCO3-[s] + taurochenodeoxycholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1875","Bile acid recycling","NA",-1000,-1000,"cholate[s] + GSH[c] + HCO3-[c] <=> cholate[c] + GSH[s] + HCO3-[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1886","Bile acid recycling","NA","NA",1000,"chenodiol[s] + glutathionyl-leukotriene C4[c] + HCO3-[c] <=> chenodiol[c] + glutathionyl-leukotriene C4[s] + HCO3-[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1889","Bile acid recycling","NA",-1000,-1000,"glutathionyl-leukotriene C4[c] + HCO3-[c] + taurocholate[s] <=> glutathionyl-leukotriene C4[s] + HCO3-[s] + taurocholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1880","Bile acid recycling","NA",-1000,-1000,"cholate[s] + glutathionyl-leukotriene C4[c] + HCO3-[c] <=> cholate[c] + glutathionyl-leukotriene C4[s] + HCO3-[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1884","Bile acid recycling","NA","NA",1000,"glycocholate[s] + HCO3-[c] + S-glutathionyl-2-4-dinitrobenzene[c] <=> glycocholate[c] + HCO3-[s] + S-glutathionyl-2-4-dinitrobenzene[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1891","Bile acid recycling","NA","NA",1000,"HCO3-[c] + S-glutathionyl-ethacrynic acid[c] + taurocholate[s] <=> HCO3-[s] + S-glutathionyl-ethacrynic acid[s] + taurocholate[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1436","Butanoate metabolism","NA",305.50577005,112.0518379559,"acetoacetate[c] + ATP[c] + CoA[c] => acetoacetyl-CoA[c] + AMP[c] + PPi[c]","ENSG00000081760"]
["HMR_1434","Butanoate metabolism","NA",305.50577005,112.0518379559,"acetoacetyl-CoA[c] + CoA[c] <=> 2 acetyl-CoA[c]","ENSG00000120437"]
["HMR_8662","C5-branched dibasic acid metabolism","NA",-1000,"NA","CoA[m] + GTP[m] + itaconate[m] <=> GDP[m] + itaconyl-CoA[m] + Pi[m]","(ENSG00000163541 and ENSG00000172340) or (ENSG00000136143 and ENSG00000163541)"]
["HMR_8663","C5-branched dibasic acid metabolism","NA",-1000,"NA","ADP[m] + itaconyl-CoA[m] + Pi[m] <=> ATP[m] + CoA[m] + itaconate[m]","(ENSG00000163541 and ENSG00000172340) or (ENSG00000136143 and ENSG00000163541)"]
["HMR_2666","Carnitine shuttle (cytosolic)",-1000,1000,1000,"(9E)-octadecenoyl-CoA[c] + L-carnitine[c] <=> (9E)-octadecenoylcarnitine[c] + CoA[c]","ENSG00000110090 or ENSG00000169169 or ENSG00000205560"]
["HMR_2636","Carnitine shuttle (cytosolic)",1000,"NA",-199.8057294938,"CoA[c] + palmitoleoyl-carnitine[c] <=> L-carnitine[c] + palmitoleoyl-CoA[c]","ENSG00000110090 or ENSG00000169169 or ENSG00000205560"]
["HMR_2633","Carnitine shuttle (cytosolic)","NA",1000,"NA","7-hexadecenoyl-CoA[c] + L-carnitine[c] <=> CoA[c] + hexadecenoylcarnitine(9)[c]","ENSG00000110090 or ENSG00000169169 or ENSG00000205560"]
["HMR_2626","Carnitine shuttle (cytosolic)","NA",1000,199.8057294938,"CoA[c] + L-palmitoylcarnitine[c] <=> L-carnitine[c] + palmitoyl-CoA[c]","ENSG00000110090 or ENSG00000169169 or ENSG00000205560"]
["HMR_2593","Carnitine shuttle (mitochondrial)",1000,422.2841065409,-563.2751812151,"CoA[m] + O-acetylcarnitine[m] <=> acetyl-CoA[m] + L-carnitine[m]","ENSG00000095321 or ENSG00000157184"]
["HMR_2596","Carnitine shuttle (mitochondrial)","NA",-1000,"NA","L-carnitine[c] + O-propanoylcarnitine[m] <=> L-carnitine[m] + O-propanoylcarnitine[c]","ENSG00000178537 or ENSG00000197119"]
["HMR_2658","Carnitine shuttle (mitochondrial)",-1000,-1000,"NA","L-carnitine[c] + octadecenoylcarnitine(5)[m] <=> L-carnitine[m] + octadecenoylcarnitine(5)[c]","ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208"]
["HMR_2655","Carnitine shuttle (mitochondrial)",-1000,1000,1000,"L-carnitine[c] + stearoylcarnitine[m] <=> L-carnitine[m] + stearoylcarnitine[c]","ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208"]
["HMR_2629","Carnitine shuttle (mitochondrial)",1000,1000,"NA","L-carnitine[c] + L-palmitoylcarnitine[m] <=> L-carnitine[m] + L-palmitoylcarnitine[c]","ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208"]
["HMR_2598","Carnitine shuttle (mitochondrial)","NA","NA",-1000,"CoA[m] + O-propanoylcarnitine[m] <=> L-carnitine[m] + propanoyl-CoA[m]","ENSG00000095321 or ENSG00000157184"]
["r1381","Cholesterol metabolism","NA",1000,"NA","lathosterol[r] <=> cholestenol[r]","ENSG00000147155"]
["EBP2r","Cholesterol metabolism","NA",1000,"NA","cholestenol[r] => lathosterol[r]","ENSG00000147155"]
["RE3446M","Eicosanoid metabolism","NA",-1000,-1000,"10,11-dihydro-12-epi-LTB4[m] + ATP[m] + CoA[m] <=> 10,11-dihydro-LTB4-CoA[m] + AMP[m] + PPi[m]","ENSG00000068366 or ENSG00000123983 or ENSG00000151726 or ENSG00000164398 or ENSG00000197142"]
["HMR_0226","Fatty acid activation (cytosolic)",1000,"NA","NA","AMP[c] + palmitoleoyl-CoA[c] + PPi[c] <=> ATP[c] + CoA[c] + palmitolate[c]","ENSG00000068366 or ENSG00000103740 or ENSG00000123983 or ENSG00000130377 or ENSG00000140284 or ENSG00000151726 or ENSG00000164398 or ENSG00000197142 or ENSG00000239642"]
["HMR_0267","Fatty acid activation (cytosolic)",1000,-1000,-1000,"(9E)-octadecenoyl-CoA[c] + AMP[c] + PPi[c] <=> ATP[c] + CoA[c] + elaidate[c]","ENSG00000068366 or ENSG00000103740 or ENSG00000123983 or ENSG00000130377 or ENSG00000140284 or ENSG00000151726 or ENSG00000164398 or ENSG00000197142 or ENSG00000239642"]
["DESAT16_2","Fatty acid biosynthesis","NA","NA",199.8057294938,"H+[c] + NADH[c] + O2[c] + palmitoyl-CoA[c] => 2 H2O[c] + NAD+[c] + palmitoleoyl-CoA[c]","ENSG00000099194"]
["HMR_2287","Fatty acid desaturation (even-chain)","NA",1000,"NA","H+[c] + NADPH[c] + O2[c] + palmitoyl-CoA[c] => 7-hexadecenoyl-CoA[c] + 2 H2O[c] + NADP+[c]","ENSG00000099194 or ENSG00000145284"]
["C51CPT1","Fatty acid oxidation","NA","NA",-1000,"L-carnitine[c] + tiglyl-CoA[c] <=> CoA[c] + Tiglyl Carnitine[c]","ENSG00000110090 or ENSG00000169169 or ENSG00000205560"]
["r1252","Fatty acid oxidation",1000,"NA","NA","ATP[c] + CoA[c] + palmitolate[c] => AMP[c] + PPi[c] + (2E)-hexadecenoyl-CoA[c]","ENSG00000068366 or ENSG00000123983 or ENSG00000130377 or ENSG00000140284 or ENSG00000151726 or ENSG00000164398 or ENSG00000197142"]
["C180CRNt","Fatty acid oxidation",-1000,1000,1000,"stearoylcarnitine[c] <=> stearoylcarnitine[m]","ENSG00000178537"]
["C161CPT12","Fatty acid oxidation",1000,"NA","NA","L-carnitine[c] + (2E)-hexadecenoyl-CoA[c] <=> CoA[c] + hexadecenoylcarnitine(9)[c]","ENSG00000110090 or ENSG00000169169 or ENSG00000205560"]
["r1447","Fatty acid oxidation","NA","NA",27.9597062413,"lauroyl-CoA[m] + ubiquinone[m] => (2E)-dodecenoyl-CoA[m] + ubiquinol[m]","ENSG00000087008 or ENSG00000161533"]
["C160CRNt","Fatty acid oxidation","NA","NA",-1000,"L-palmitoylcarnitine[c] <=> L-palmitoylcarnitine[m]","ENSG00000178537"]
["FACOAL1813","Fatty acid oxidation",1000,-1000,-1000,"ATP[c] + CoA[c] + elaidate[c] <=> (2E)-octadecenoyl-CoA[c] + AMP[c] + PPi[c]","ENSG00000151726"]
["2MB2COAc","Fatty acid oxidation","NA","NA",-1000,"tiglyl-CoA[m] <=> tiglyl-CoA[c]","ENSG00000155368"]
["PCRNtm","Fatty acid oxidation","NA",-1000,-1000,"O-propanoylcarnitine[c] <=> O-propanoylcarnitine[m]","ENSG00000178537"]
["ELAIDCPT1","Fatty acid oxidation",1000,-1000,-1000,"(2E)-octadecenoyl-CoA[c] + L-carnitine[c] <=> (9E)-octadecenoylcarnitine[c] + CoA[c]","ENSG00000110090 or ENSG00000169169 or ENSG00000205560"]
["C181CRNt","Fatty acid oxidation","NA","NA",1000,"octadecenoylcarnitine(5)[c] <=> octadecenoylcarnitine(5)[m]","ENSG00000178537"]
["r0735","Fatty acid oxidation","NA",-83.453446828,"NA","decanoyl-CoA[m] + NADP+[m] <=> (2E)-decenoyl-CoA[m] + H+[m] + NADPH[m]","ENSG00000115425 or ENSG00000116353"]
["r0638","Fatty acid oxidation","NA","NA",-27.9597062413,"lauroyl-CoA[m] + NADP+[m] <=> (2E)-dodecenoyl-CoA[m] + H+[m] + NADPH[m]","ENSG00000115425 or ENSG00000116353"]
["HMR_4444","Folate metabolism",1000,1000,-165.0501592836,"5,10-methenyl-THF[m] + NADPH[m] <=> 5,10-methylene-THF[m] + NADP+[m]","ENSG00000065911 or ENSG00000100714 or ENSG00000120254"]
["HMR_4656","Folate metabolism","NA","NA",502.3156583459,"folate[m] + NADPH[m] => dihydrofolate[m] + NADP+[m]","ENSG00000178700 or ENSG00000228716"]
["HMR_3923","Folate metabolism","NA","NA",502.3156583459,"glycine[m] + NAD+[m] + THF[m] => 5,10-methylene-THF[m] + CO2[m] + H+[m] + NADH[m] + NH3[m]","ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"]
["HMR_4448","Folate metabolism","NA",791.5742648436,507.5679530585,"5,10-methylene-THF[c] + 2 H+[c] + NADH[c] => 5-methyl-THF[c] + NAD+[c]","ENSG00000177000"]
["HMR_4440","Folate metabolism",-1000,-1000,165.0501592836,"5,10-methenyl-THF[m] + NADH[m] <=> 5,10-methylene-THF[m] + NAD+[m]","ENSG00000065911 or ENSG00000163738"]
["HMR_4335","Folate metabolism","NA","NA",502.3156583459,"dihydrofolate[m] + H+[m] + NADPH[m] <=> NADP+[m] + THF[m]","ENSG00000178700 or ENSG00000228716"]
["HMR_4315","Fructose and mannose metabolism","NA","NA",-666.6666666667,"D-glucitol[c] + NAD+[c] <=> fructose[c] + H+[c] + NADH[c]","ENSG00000140263"]
["HMR_4775","Galactose metabolism","NA",1000,941.7872359205,"D-tagatose-6-phosphate[c] + ITP[c] <=> H+[c] + IDP[c] + tagatose-1,6-bisphosphate[c]","ENSG00000067057 or ENSG00000141959 or ENSG00000152556"]
["HMR_4774","Galactose metabolism","NA",1000,941.7872359205,"CDP[c] + H+[c] + tagatose-1,6-bisphosphate[c] <=> CTP[c] + D-tagatose-6-phosphate[c]","ENSG00000067057 or ENSG00000141959 or ENSG00000152556"]
["HMR_3933","Glutathione metabolism",1000,-1000,800.1942705062,"formylglutathione[c] + H+[c] + NADH[c] <=> hydroxymethylglutathione[c] + NAD+[c]","ENSG00000197894"]
["HMR_4120","Glutathione metabolism","NA","NA",367.561074175,"2 GSH[s] + H2O2[s] => GSSG[s] + 2 H2O[s]","ENSG00000116157 or ENSG00000117450 or ENSG00000117592 or ENSG00000126432 or ENSG00000164294 or ENSG00000165672 or ENSG00000167468 or ENSG00000167815 or ENSG00000176153 or ENSG00000198704 or ENSG00000211445 or ENSG00000224586 or ENSG00000233276"]
["HMR_3937","Glutathione metabolism","NA","NA",199.8057294938,"formylglutathione[c] + H2O[c] => formate[c] + GSH[c] + H+[c]","ENSG00000139684"]
["HMR_8769","Glutathione metabolism","NA","NA",13.0606185,"alanine[c] + GSH[c] => (5-L-glutamyl)-L-amino acid[s] + cys-gly[s]","ENSG00000099998 or ENSG00000100031 or ENSG00000100121 or ENSG00000131067 or ENSG00000133475 or ENSG00000149435 or ENSG00000167741"]
["HMR_7612","Glycerophospholipid metabolism",1000,1000,"NA","2-acetyl-1-alkyl-sn-glycero-3-phosphocholine[s] + H2O[s] => 1-organyl-2-lyso-sn-glycero-3-phosphocholine[s] + acetate[s] + H+[s]","ENSG00000146070"]
["HMR_3843","Glycine, serine and threonine metabolism","NA",271.9872962,40.2740436901,"3-phosphoserine[c] + H2O[c] => Pi[c] + serine[c]","ENSG00000111237 or ENSG00000146733"]
["HMR_6409","Glycine, serine and threonine metabolism","NA","NA",-56.5024205382,"H+[m] + lipoamide[m] + NADH[m] <=> dihydrolipoamide[m] + NAD+[m]","ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445"]
["HMR_3845","Glycine, serine and threonine metabolism",-1000,"NA",-395.4345462567,"serine[c] + THF[c] <=> 5,10-methylene-THF[c] + glycine[c] + H2O[c]","ENSG00000176974"]
["HMR_3841","Glycine, serine and threonine metabolism","NA",271.9872962,40.2740436901,"3-phosphonooxypyruvate[c] + glutamate[c] <=> 3-phosphoserine[c] + AKG[c]","ENSG00000135069"]
["HMR_3839","Glycine, serine and threonine metabolism","NA",271.9872962,40.2740436901,"3-phospho-D-glycerate[c] + NAD+[c] <=> 3-phosphonooxypyruvate[c] + H+[c] + NADH[c]","ENSG00000092621 or ENSG00000134882"]
["HMR_3752","Glycine, serine and threonine metabolism",211.8312062398,1000,"NA","FADH2[m] + methacrylyl-CoA[m] <=> FAD[m] + isobutyryl-CoA[m]","ENSG00000196177"]
["HMR_7747","Glycolysis / Gluconeogenesis","NA","NA",666.6666666667,"ADP[c] + beta-D-glucose[c] => AMP[c] + beta-D-glucose-6-phosphate[c] + H+[c]","ENSG00000159322"]
["HMR_4381","Glycolysis / Gluconeogenesis",1000,-1000,-1000,"fructose-6-phosphate[c] <=> glucose-6-phosphate[c]","ENSG00000105220"]
["HMR_4301","Glycolysis / Gluconeogenesis","NA",585.9047932,"NA","fructose-6-phosphate[c] + UTP[c] => fructose-1,6-bisphosphate[c] + H+[c] + UDP[c]","ENSG00000067057 or ENSG00000141959 or ENSG00000152556 or ENSG00000160226"]
["HMR_6410","Glycolysis / Gluconeogenesis","NA","NA",56.5024205382,"H+[m] + lipoamide[m] + pyruvate[m] => CO2[m] + S-acetyldihydrolipoamide[m]","(ENSG00000131828 and ENSG00000168291) or (ENSG00000163114 and ENSG00000168291)"]
["HMR_4391","Glycolysis / Gluconeogenesis",636.6417167713,-259.5604591749,348.5912800842,"DHAP[c] <=> GAP[c]","ENSG00000111669"]
["HMR_4358","Glycolysis / Gluconeogenesis","NA","NA",1000,"ADP[c] + H+[c] + PEP[c] => ATP[c] + pyruvate[c]","ENSG00000067225 or ENSG00000121900 or ENSG00000143627 or ENSG00000143630"]
["HMR_7748","Glycolysis / Gluconeogenesis",-1000,1000,1000,"beta-D-glucose-6-phosphate[c] <=> glucose-6-phosphate[c]","ENSG00000105220"]
["HMR_4355","Glycolysis / Gluconeogenesis",363.3582832287,"NA","NA","DHAP[c] + erythrose-4-phosphate[c] => sedoheptulose-1,7-bisphosphate[c]","ENSG00000109107 or ENSG00000136872 or ENSG00000149925 or ENSG00000285043"]
["HMR_4137","Glycolysis / Gluconeogenesis","NA",141.2864781773,"NA","CoA[m] + NAD+[m] + pyruvate[m] => acetyl-CoA[m] + CO2[m] + NADH[m]","ENSG00000091140 and ENSG00000110435 and (ENSG00000131828 or ENSG00000163114) and ENSG00000150768 and ENSG00000168291"]
["HMR_7745","Glycolysis / Gluconeogenesis","NA","NA",-666.6666666667,"beta-D-glucose[c] <=> glucose[c]","ENSG00000143891"]
["HMR_6412","Glycolysis / Gluconeogenesis","NA","NA",56.5024205382,"CoA[m] + S-acetyldihydrolipoamide[m] => acetyl-CoA[m] + dihydrolipoamide[m]","(ENSG00000091140 and ENSG00000131828 and ENSG00000150768 and ENSG00000168291) or (ENSG00000091140 and ENSG00000150768 and ENSG00000163114 and ENSG00000168291)"]
["HMR_7749","Glycolysis / Gluconeogenesis",1000,-1000,-333.3333333333,"beta-D-glucose-6-phosphate[c] <=> fructose-6-phosphate[c]","ENSG00000105220"]
["HMR_1264","Leukotriene metabolism","NA",-1000,-1000,"10,11-dihydro-LTB4-CoA[m] + AMP[m] + PPi[m] <=> 10,11-dihydro-LTB4[m] + ATP[m] + CoA[m]","ENSG00000068366 or ENSG00000103740 or ENSG00000123983 or ENSG00000130377 or ENSG00000140284 or ENSG00000151726 or ENSG00000164398 or ENSG00000197142 or ENSG00000239642"]
["HMR_1232","Leukotriene metabolism","NA",1000,1000,"10,11-dihydro-12-oxo-LTB4[m] + H+[m] + NADPH[m] => 10,11-dihydro-LTB4[m] + NADP+[m]","ENSG00000157326 or ENSG00000159228 or ENSG00000159231"]
["HMR_1281","Leukotriene metabolism","NA",1000,1000,"10,11-dihydro-12-epi-LTB4[m] + NADP+[m] <=> 10,11-dihydro-12-oxo-LTB4[m] + H+[m] + NADPH[m]","ENSG00000157326 or ENSG00000159228 or ENSG00000159231"]
["HMR_3955","Miscellaneous",1000,"NA","NA","CO2[c] + H2O[c] => H+[c] + HCO3-[c]","ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000178538 or ENSG00000185015"]
["HMR_5407","Miscellaneous",-1000,-176.1279407588,1000,"CO2[s] + H2O[s] <=> carbonate[s]","ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000178538 or ENSG00000185015"]
["HMR_5128","Miscellaneous",-836.1055801019,-465.1290253681,"NA","NH4+[s] <=> H+[s] + NH3[s]"]
["RE1860E","Miscellaneous",554.3427334206,-1000,-1000,"H2O[s] + 2,3-cyclic-UMP[s] <=> H+[s] + 3-UMP[s]","ENSG00000173786"]
["HMR_4201","Miscellaneous","NA","NA",199.8057294938,"H2O2[c] + methanol[c] => formaldehyde[c] + 2 H2O[c]","ENSG00000117592 or ENSG00000121053 or ENSG00000121691 or ENSG00000130508 or ENSG00000147485 or ENSG00000167419"]
["HMR_7580","N-glycan metabolism","NA",931.1448719088,"NA","H2O[s] + PA6[s] => 6-deoxy-L-galactose[s] + de-Fuc form of PA6[s]","ENSG00000001036 or ENSG00000179163"]
["HMR_8791","Nicotinate and nicotinamide metabolism","NA",-615.155084125,"NA","H+[c] + nicotinamide[c] + ribose-1-phosphate[c] <=> nicotinamide ribonucleoside[c] + Pi[c]","ENSG00000198805"]
["HMR_4262","Nicotinate and nicotinamide metabolism","NA",-615.155084125,"NA","nicotinamide D-ribonucleotide[c] + PPi[c] <=> H+[c] + nicotinamide[c] + PRPP[c]","ENSG00000105835"]
["HMR_4264","Nicotinate and nicotinamide metabolism","NA",615.155084125,"NA","H2O[c] + nicotinamide D-ribonucleotide[c] => nicotinamide ribonucleoside[c] + Pi[c]","ENSG00000014257 or ENSG00000076685 or ENSG00000116981 or ENSG00000122643 or ENSG00000125458 or ENSG00000135318 or ENSG00000141698 or ENSG00000185013 or ENSG00000205309 or ENSG00000250741"]
["HMR_8449","Nucleotide metabolism","NA",1000,1000,"CDP[n] + dGDP[n] <=> CMP[n] + dGTP[n]","ENSG00000162368"]
["HMR_7874","Nucleotide metabolism",1000,"NA","NA","dGDP[n] + UDP[n] <=> dGTP[n] + UMP[n]","ENSG00000162368"]
["HMR_8453","Nucleotide metabolism",-1000,1000,1000,"2 dCDP[n] <=> dCMP[n] + dCTP[n]","ENSG00000162368"]
["HMR_4680","Nucleotide metabolism","NA",561.056394275,-836.9312687021,"2-deoxy-D-ribose-1-phosphate[c] + uracil[c] <=> deoxyuridine[c] + Pi[c]","ENSG00000007001 or ENSG00000183696"]
["HMR_7800","Nucleotide metabolism",1000,-305.50577005,-1000,"ADP[c] + GDP[c] <=> AMP[c] + GTP[c]","ENSG00000154027"]
["HMR_7864","Nucleotide metabolism",1000,"NA","NA","CDP[n] + UDP[n] <=> CTP[n] + UMP[n]","ENSG00000162368"]
["HMR_8463","Nucleotide metabolism",1000,"NA","NA","CDP[c] + dCDP[c] <=> CTP[c] + dCMP[c]","ENSG00000162368"]
["HMR_8450","Nucleotide metabolism","NA",970.749709075,1000,"dCDP[c] + dGDP[c] <=> dCMP[c] + dGTP[c]","ENSG00000162368"]
["HMR_8487","Nucleotide metabolism",966.6264273,"NA",853.72059365,"H2O[s] + UMP[s] => Pi[s] + uridine[s]","ENSG00000122643 or ENSG00000135318"]
["HMR_8461","Nucleotide metabolism","NA",-1000,-1000,"dCDP[c] + GDP[c] <=> dCMP[c] + GTP[c]","ENSG00000154027"]
["HMR_8452","Nucleotide metabolism","NA",1000,1000,"2 dCDP[c] <=> dCMP[c] + dCTP[c]","ENSG00000162368"]
["HMR_8472","Nucleotide metabolism",1000,-1000,-1000,"CDP[n] + dCDP[n] <=> CMP[n] + dCTP[n]","ENSG00000162368"]
["HMR_7868","Nucleotide metabolism",-1000,1000,1000,"GDP[n] + UDP[n] <=> GTP[n] + UMP[n]","ENSG00000162368"]
["HMR_7870","Nucleotide metabolism",1000,-1000,-1000,"dADP[n] + UDP[n] <=> dATP[n] + UMP[n]","ENSG00000162368"]
["HMR_8459","Nucleotide metabolism",1000,-1000,-1000,"ADP[n] + dCDP[n] <=> ATP[n] + dCMP[n]","ENSG00000162368"]
["HMR_7876","Nucleotide metabolism",-1000,1000,1000,"ADP[n] + UDP[n] <=> ATP[n] + UMP[n]","ENSG00000162368"]
["HMR_7873","Nucleotide metabolism",-1000,1000,-1000,"dGDP[c] + UDP[c] <=> dGTP[c] + UMP[c]","ENSG00000162368"]
["HMR_8471","Nucleotide metabolism",1000,-1000,1000,"CDP[c] + dCDP[c] <=> CMP[c] + dCTP[c]","ENSG00000162368"]
["HMR_8462","Nucleotide metabolism",1000,"NA","NA","dCDP[n] + GDP[n] <=> dCMP[n] + GTP[n]","ENSG00000162368"]
["HMR_7871","Nucleotide metabolism",-1000,-1000,"NA","dCDP[c] + UDP[c] <=> dCTP[c] + UMP[c]","ENSG00000162368"]
["HMR_8460","Nucleotide metabolism","NA",-1000,-1000,"CDP[n] + dCDP[n] <=> CTP[n] + dCMP[n]","ENSG00000162368"]
["HMR_8464","Nucleotide metabolism","NA",-1000,-1000,"CDP[n] + GDP[n] <=> CMP[n] + GTP[n]","ENSG00000162368"]
["HMR_7890","Nucleotide metabolism",1000,"NA",1000,"ADP[m] + dCTP[m] <=> ATP[m] + dCDP[m]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000155085 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_8467","Nucleotide metabolism",1000,970.749709075,-223.7338342184,"CDP[c] + UDP[c] <=> CMP[c] + UTP[c]","ENSG00000162368"]
["HMR_8466","Nucleotide metabolism",-1000,1000,1000,"2 CDP[n] <=> CMP[n] + CTP[n]","ENSG00000162368"]
["HMR_8448","Nucleotide metabolism","NA",29.250290925,-1000,"CDP[c] + dGDP[c] <=> CMP[c] + dGTP[c]","ENSG00000162368"]
["HMR_7867","Nucleotide metabolism",1000,-384.844915875,163.0687312979,"GDP[c] + UDP[c] <=> GTP[c] + UMP[c]","ENSG00000162368"]
["HMR_8455","Nucleotide metabolism",-1000,1000,1000,"dADP[n] + dCDP[n] <=> dATP[n] + dCMP[n]","ENSG00000162368"]
["HMR_7801","Nucleotide metabolism",1000,-1000,1000,"ADP[m] + GDP[m] <=> AMP[m] + GTP[m]","ENSG00000147853"]
["HMR_3967","Nucleotide metabolism",-1000,1000,836.9312687021,"CDP[c] + GDP[c] <=> CMP[c] + GTP[c]","ENSG00000162368"]
["HMR_3968","Nucleotide metabolism","NA","NA",159.15191069,"ADP[c] + dUDP[c] <=> ATP[c] + dUMP[c]","ENSG00000168393"]
["HMR_3977","Oxidative phosphorylation","NA",305.50577005,112.0518379559,"H2O[c] + PPi[c] => H+[c] + 2 Pi[c]","ENSG00000107902 or ENSG00000138777 or ENSG00000143363 or ENSG00000180817"]
["HMR_6916","Oxidative phosphorylation",411.4368366741,"NA","NA","ADP[m] + Pi[m] + 3 H+[i] => ATP[m] + 2 H+[m] + H2O[m]","ENSG00000099624 and ENSG00000110955 and ENSG00000116459 and ENSG00000124172 and ENSG00000135390 and ENSG00000152234 and ENSG00000154518 and ENSG00000154723 and ENSG00000156411 and ENSG00000159199 and ENSG00000165629 and ENSG00000167283 and ENSG00000167863 and ENSG00000169020 and ENSG00000173915 and ENSG00000198899 and ENSG00000228253 and ENSG00000241468 and ENSG00000241837"]
["HMR_8341","Pentose and glucuronate interconversions","NA","NA",666.6666666667,"H+[c] + L-arabinose[c] + NADPH[c] => L-arabitol[c] + NADP+[c]","ENSG00000053371 or ENSG00000085662 or ENSG00000117448"]
["HMR_8342","Pentose and glucuronate interconversions","NA","NA",-666.6666666667,"H+[c] + L-xylulose[c] + NADH[c] <=> L-arabitol[c] + NAD+[c]"]
["HMR_4592","Pentose and glucuronate interconversions","NA","NA",-666.6666666667,"D-xylose[c] + H+[c] + NADPH[c] <=> NADP+[c] + xylitol[c]","ENSG00000085662 or ENSG00000198074"]
["HMR_4590","Pentose and glucuronate interconversions","NA","NA",666.6666666667,"H+[c] + L-xylulose[c] + NADPH[c] => NADP+[c] + xylitol[c]","ENSG00000169738"]
["HMR_4306","Pentose phosphate pathway",1000,1000,"NA","glucono-1,5-lactone-6-phosphate[c] + H+[c] + NADPH[c] <=> glucose-6-phosphate[c] + NADP+[c]","ENSG00000160211"]
["HMR_4354","Pentose phosphate pathway",-819.8503006277,878.8571898,-1000,"ribose-1-phosphate[c] <=> ribose-5-phosphate[c]","ENSG00000079739 or ENSG00000169299"]
["HMR_4404","Pentose phosphate pathway",-273.2834335426,292.9523966,-333.3333333333,"D-xylulose-5-phosphate[c] + erythrose-4-phosphate[c] <=> fructose-6-phosphate[c] + GAP[c]","ENSG00000007350 or ENSG00000151005 or ENSG00000163931"]
["HMR_4352","Pentose phosphate pathway",-546.5668670851,585.9047932,-666.6666666667,"ribose-5-phosphate[c] <=> ribulose-5-phosphate[c]","ENSG00000153574"]
["HMR_4565","Pentose phosphate pathway",90.0748496862,292.9523966,-333.3333333333,"GAP[c] + sedoheptulose-7-phosphate[c] <=> erythrose-4-phosphate[c] + fructose-6-phosphate[c]","ENSG00000177156"]
["G6PDH2c","Pentose phosphate pathway",333.3333333333,333.3333333333,"NA","3 glucose-6-phosphate[c] + 3 NADP+[c] => 3 glucono-1,5-lactone-6-phosphate[c] + 3 H+[c] + 3 NADPH[c]","ENSG00000160211"]
["HMR_4501","Pentose phosphate pathway",-273.2834335426,292.9523966,-333.3333333333,"D-xylulose-5-phosphate[c] + ribose-5-phosphate[c] <=> GAP[c] + sedoheptulose-7-phosphate[c]","ENSG00000007350 or ENSG00000151005 or ENSG00000163931"]
["HMR_4398","Pentose phosphate pathway","NA","NA",636.150773165,"2-deoxy-D-ribose-5-phosphate[c] <=> acetaldehyde[c] + GAP[c]","ENSG00000023697"]
["HMR_4710","Pentose phosphate pathway","NA","NA",636.150773165,"2-deoxy-D-ribose-1-phosphate[c] <=> 2-deoxy-D-ribose-5-phosphate[c]","ENSG00000169299 or ENSG00000180953"]
["PHETA1m","Phenylalanine metabolism","NA",-987.43001925,"NA","AKG[m] + phenylalanine[m] <=> glutamate[m] + phenylpyruvate[m]","ENSG00000125166 or ENSG00000198650"]
["HMR_3797","Propanoate metabolism",1000,1000,-1000,"AMP[m] + PPi[m] + propanoyl-CoA[m] <=> ATP[m] + CoA[m] + propanoate[m]","ENSG00000111058 or ENSG00000131069 or ENSG00000154930"]
["HMR_4460","Propanoate metabolism",1000,1000,-1000,"ATP[m] + H+[m] + propanoate[m] <=> PPi[m] + propinol adenylate[m]","ENSG00000111058 or ENSG00000131069 or ENSG00000154930"]
["HMR_1325","Prostaglandin biosynthesis","NA","NA",1000,"NAD+[c] + prostaglandin F2alpha[c] => H+[c] + NADH[c] + prostaglandin H2[c]","ENSG00000196139"]
["HMR_1330","Prostaglandin biosynthesis","NA","NA",1000,"prostaglandin H2[c] => prostaglandin D2[c]","ENSG00000107317 or ENSG00000163106"]
["HMR_1329","Prostaglandin biosynthesis","NA","NA",1000,"H+[c] + NADPH[c] + prostaglandin D2[c] <=> NADP+[c] + prostaglandin F2alpha[c]","ENSG00000196139"]
["HMR_4004","Purine metabolism",-1000,1000,-1000,"2 ADP[m] <=> AMP[m] + ATP[m]","ENSG00000004455 or ENSG00000085231 or ENSG00000106992 or ENSG00000140057 or ENSG00000147853 or ENSG00000154027 or ENSG00000155085 or ENSG00000162433 or ENSG00000165695 or ENSG00000273841"]
["HMR_4002","Purine metabolism","NA",1000,1000,"2 ADP[c] <=> AMP[c] + ATP[c]","ENSG00000004455 or ENSG00000085231 or ENSG00000106992 or ENSG00000140057 or ENSG00000147853 or ENSG00000154027 or ENSG00000155085 or ENSG00000162433 or ENSG00000165695 or ENSG00000273841"]
["HMR_4418","Purine metabolism","NA","NA",316.7871561205,"IMP[c] + PPi[c] <=> hypoxanthine[c] + PRPP[c]","ENSG00000165704"]
["HMR_4291","Purine metabolism","NA",-1000,-1000,"ADP[c] + ITP[c] <=> ATP[c] + IDP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4016","Purine metabolism",1000,-690.3506859251,-1000,"ADP[c] + GTP[c] <=> ATP[c] + GDP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4570","Purine metabolism",-1000,1000,-1000,"ADP[c] + dGTP[c] <=> ATP[c] + dGDP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4044","Purine metabolism",-1000,1000,-1000,"ADP[c] + dATP[c] <=> ATP[c] + dADP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4651","Purine metabolism",-1000,438.943605725,-1000,"guanosine[c] + Pi[c] <=> guanine[c] + ribose-1-phosphate[c]","ENSG00000198805"]
["HMR_4574","Purine metabolism",180.1496993723,-175.24150005,58.2127640795,"inosine[c] + Pi[c] <=> hypoxanthine[c] + ribose-1-phosphate[c]","ENSG00000198805"]
["HMR_4572","Purine metabolism","NA",1000,"NA","ADP[m] + dGTP[m] => ATP[m] + dGDP[m]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4489","Purine metabolism",183.2085838564,"NA","NA","dATP[c] + fructose[c] => dADP[c] + fructose-6-phosphate[c] + H+[c]","ENSG00000156510 or ENSG00000156515 or ENSG00000159399 or ENSG00000160883"]
["HMR_4421","Purine metabolism","NA",347.3094344251,"NA","dADP[c] + H+[c] + PEP[c] => dATP[c] + pyruvate[c]","ENSG00000067225 or ENSG00000143627"]
["HMR_4018","Purine metabolism",1000,"NA",1000,"ADP[m] + GTP[m] <=> ATP[m] + GDP[m]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4621","Purine metabolism","NA","NA",159.15191069,"thioredoxin[c] + UDP[c] => dUDP[c] + H2O[c] + oxidized thioredoxin[c]","(ENSG00000048392 and ENSG00000100348 and ENSG00000167325 and ENSG00000171848) or (ENSG00000048392 and ENSG00000136810 and ENSG00000167325 and ENSG00000171848)"]
["HMR_4080","Purine metabolism","NA","NA",316.7871561205,"AMP[c] + H2O[c] => IMP[c] + NH3[c]","ENSG00000116337 or ENSG00000116748 or ENSG00000133805"]
["HMR_4611","Purine metabolism","NA",512.4287345499,"NA","ATP[c] + thioredoxin[c] => dATP[c] + H2O[c] + oxidized thioredoxin[c]","(ENSG00000048392 and ENSG00000100348 and ENSG00000167325 and ENSG00000171848) or (ENSG00000048392 and ENSG00000136810 and ENSG00000167325 and ENSG00000171848)"]
["HMR_4709","Purine metabolism",1000,"NA",1000,"2-deoxy-D-ribose-1-phosphate[c] + hypoxanthine[c] <=> deoxyinosine[c] + Pi[c]","ENSG00000025708 or ENSG00000198805"]
["HMR_4635","Pyrimidine metabolism",-183.2085838564,-1000,"NA","ADP[c] + dTTP[c] <=> ATP[c] + dTDP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4642","Pyrimidine metabolism","NA","NA",159.15191069,"dUMP[c] + H2O[c] => deoxyuridine[c] + Pi[c]","ENSG00000125458 or ENSG00000205309"]
["HMR_4006","Pyrimidine metabolism",363.3582832287,-1000,-1000,"ADP[c] + UTP[c] <=> ATP[c] + UDP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_6627","Pyrimidine metabolism",-1000,"NA",-1000,"dTDP[c] + H+[c] + PEP[c] <=> dTTP[c] + pyruvate[c]","ENSG00000067225 or ENSG00000143627"]
["HMR_4670","Pyrimidine metabolism",-1000,-1000,1000,"ADP[c] + dCTP[c] <=> ATP[c] + dCDP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4210","Pyrimidine metabolism",1000,"NA",901.5131922305,"H+[c] + PEP[c] + UDP[c] => pyruvate[c] + UTP[c]","ENSG00000067225 or ENSG00000143627"]
["HMR_3969","Pyrimidine metabolism","NA","NA",58.2127640795,"ITP[c] + uridine[c] => H+[c] + IDP[c] + UMP[c]","ENSG00000130717 or ENSG00000143179"]
["HMR_6614","Pyrimidine metabolism",-816.7914161436,1000,-1000,"dADP[c] + dTTP[c] <=> dATP[c] + dTDP[c]","ENSG00000011052 or ENSG00000103024 or ENSG00000103202 or ENSG00000112981 or ENSG00000143156 or ENSG00000172113 or ENSG00000239672 or ENSG00000243678"]
["HMR_4091","Pyruvate metabolism","NA",141.2864781773,"NA","malate[m] + NADP+[m] => CO2[m] + NADPH[m] + pyruvate[m]","ENSG00000082212 or ENSG00000151376"]
["HMR_4087","Pyruvate metabolism","NA","NA",56.5024205382,"malate[m] + NAD+[m] => CO2[m] + NADH[m] + pyruvate[m]","ENSG00000082212 or ENSG00000151376"]
["HMR_4143","Pyruvate metabolism",327.9626769379,"NA","NA","ATP[m] + HCO3-[m] + pyruvate[m] => ADP[m] + H+[m] + OAA[m] + Pi[m]","ENSG00000173599"]
["HMR_1568","Pyruvate metabolism","NA","NA",636.150773165,"acetaldehyde[c] + H2O[c] + NAD+[c] => acetate[c] + 2 H+[c] + NADH[c]","ENSG00000006534 or ENSG00000108602 or ENSG00000132746 or ENSG00000184254"]
["HMR_4193","Pyruvate metabolism","NA","NA",58.2127640795,"CDP[c] + H+[c] + PEP[c] => CTP[c] + pyruvate[c]","ENSG00000067225 or ENSG00000143627"]
["HMR_6661","Retinol metabolism","NA",168.0249961276,"NA","13-cis-retinoate[c] <=> retinoate[c]","ENSG00000134184"]
["HMR_6675","Retinol metabolism","NA",168.0249961276,"NA","13-cis-retinal[c] + H2O[c] + NAD+[c] <=> 13-cis-retinoate[c] + 2 H+[c] + NADH[c]","ENSG00000128918 or ENSG00000165092"]
["HMR_6672","Retinol metabolism","NA",-168.0249961276,"NA","13-cis-retinal[c] <=> retinal[c]"]
["HMR_8698","Retinol metabolism",321.8657383,"NA","NA","2 H+[c] + NADPH[c] + retinoate[c] <=> H2O[c] + NADP+[c] + retinal[c]"]
["HMR_3980","ROS detoxification",34.7756230244,98.3809790348,"NA","2 H2O2[c] => 2 H2O[c] + O2[c]","ENSG00000121691"]
["HMR_4561","Serotonin and melatonin biosynthesis","NA",-338.4899238488,"NA","5-hydroxyindoleacetaldehyde[c] + H+[c] + NADPH[c] <=> 5-hydroxytryptophol[c] + NADP+[c]","ENSG00000147576 or ENSG00000172955 or ENSG00000187758 or ENSG00000196344 or ENSG00000196616 or ENSG00000197894 or ENSG00000198099 or ENSG00000248144"]
["HMR_4559","Serotonin and melatonin biosynthesis","NA",338.4899238488,"NA","5-hydroxyindoleacetaldehyde[c] + H2O[c] + NAD+[c] => 5-hydroxyindoleacetate[c] + 2 H+[c] + NADH[c]","ENSG00000072210 or ENSG00000111275 or ENSG00000137124 or ENSG00000143149 or ENSG00000164904"]
["HMR_0766","Sphingolipid metabolism",213.1499046274,"NA","NA","galactose[s] + glucosylceramide pool[s] => H2O[s] + LacCer pool[s]","ENSG00000115850 or ENSG00000163521 or ENSG00000170266"]
["TREH","Starch and sucrose metabolism","NA",182.896178075,"NA","H2O[c] + trehalose[c] => 2 glucose[c]","ENSG00000118094 or ENSG00000142102"]
["HMR_3989","Starch and sucrose metabolism","NA",244.98306885,"NA","H2O[s] + maltose[s] => 2 glucose[s]","ENSG00000092529 or ENSG00000171298 or ENSG00000214013 or ENSG00000257335"]
["HMR_8582","Starch and sucrose metabolism","NA","NA",327.8179422083,"H2O[c] + maltose[c] => 2 fructose[c]","ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"]
["HMR_8573","Starch and sucrose metabolism","NA","NA",881.4015547,"H2O[s] + maltoheptaose[s] => glucose[s] + maltohexaose[s]","ENSG00000120563 or ENSG00000174876 or ENSG00000187733 or ENSG00000237763 or ENSG00000240038 or ENSG00000243480"]
["HMR_5662","Transport reactions",1000,"NA","NA","glycine[c] + Na+[s] + tryptophan[s] => glycine[s] + Na+[c] + tryptophan[c]","ENSG00000103064 or ENSG00000103257"]
["HDCECRNtr","Transport reactions",1000,"NA","NA","palmitoleoyl-carnitine[s] <=> palmitoleoyl-carnitine[c]"]
["HMR_5889","Transport reactions","NA",153.8564589273,"NA","Na+[s] + ornithine[c] + valine[s] => Na+[c] + ornithine[s] + valine[c]","ENSG00000103064"]
["HMR_6324","Transport reactions","NA",1000,1000,"arginine[m] + H+[c] => arginine[c] + H+[m]","ENSG00000102743 or ENSG00000120329"]
["HMR_5042","Transport reactions",-180.1496993723,175.24150005,-58.2127640795,"inosine[c] <=> inosine[s]","ENSG00000112759 or ENSG00000174669"]
["HMR_6002","Transport reactions",-1000,-1000,524.0989352091,"acetoacetate[c] + formate[s] <=> acetoacetate[s] + formate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_6047","Transport reactions",-1000,-1000,636.150773165,"(R)-3-hydroxybutanoate[c] + acetoacetate[s] <=> (R)-3-hydroxybutanoate[s] + acetoacetate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_7818","Transport reactions",897.6449787556,1000,-1000,"dGDP[c] + dTDP[m] <=> dGDP[m] + dTDP[c]","ENSG00000125454"]
["HMR_9605","Transport reactions",61.75339325,"NA","NA","alanine[s] + H+[c] + Na+[s] => alanine[c] + H+[s] + Na+[c]","ENSG00000017483"]
["HMR_5745","Transport reactions",155.8570612,"NA","NA","cysteine[c] + Na+[s] + proline[s] => cysteine[s] + Na+[c] + proline[c]","ENSG00000103064"]
["HMR_1901","Transport reactions","NA",1000,1000,"glutathionyl-leukotriene C4[c] + HCO3-[c] + serotonin[s] <=> glutathionyl-leukotriene C4[s] + HCO3-[s] + serotonin[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1602","Transport reactions",-104.3268690731,-295.1429371045,"NA","5beta-cholestan-3alpha,7alpha,12alpha-triol[c] <=> 5beta-cholestan-3alpha,7alpha,12alpha-triol[m]"]
["HMR_8867","Transport reactions","NA","NA",666.6666666667,"D-xylose[c] <=> D-xylose[s]","ENSG00000059804"]
["HMR_5880","Transport reactions","NA",271.9872962,"NA","histidine[c] + Na+[s] + proline[s] => histidine[s] + Na+[c] + proline[c]","ENSG00000103064"]
["HMR_8889","Transport reactions",19.1468509448,"NA",1000,"betaine[s] + 2 Na+[s] => betaine[c] + 2 Na+[c]","ENSG00000111181"]
["HMR_8670","Transport reactions","NA",127.1964035175,898.802859976,"2 chloride[s] + formate[c] => 2 chloride[c] + formate[s]","ENSG00000225697"]
["HMR_5448","Transport reactions",1000,"NA","NA","HCO3-[c] + 2 Na+[c] => HCO3-[s] + 2 Na+[s]","ENSG00000080493 or ENSG00000188687"]
["HMR_7849","Transport reactions","NA",1000,"NA","dGTP[c] + dUDP[m] => dGTP[m] + dUDP[c]","ENSG00000125454"]
["HMR_5538","Transport reactions","NA",-1000,-1000,"phenylalanine[c] + valine[s] <=> phenylalanine[s] + valine[c]","ENSG00000103257 or ENSG00000165029"]
["HMR_6015","Transport reactions",1000,872.8035964825,-1000,"acetate[c] + pyruvate[s] <=> acetate[s] + pyruvate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_5116","Transport reactions","NA",987.43001925,"NA","phenylalanine[m] + H+[i] => H+[m] + phenylalanine[c]"]
["HMR_5767","Transport reactions","NA",846.1435410727,"NA","glycine[c] + Na+[s] + valine[s] => glycine[s] + Na+[c] + valine[c]","ENSG00000103064"]
["HMR_4882","Transport reactions","NA",54.09868985,1000,"uracil[c] <=> uracil[s]","ENSG00000174669"]
["HMR_7822","Transport reactions",-897.6449787556,-1000,1000,"dCDP[c] + dTDP[m] <=> dCDP[m] + dTDP[c]","ENSG00000125454"]
["HMR_1908","Transport reactions","NA",-1000,"NA","dopamine[s] + HCO3-[c] + S-glutathionyl-2-4-dinitrobenzene[c] <=> dopamine[c] + HCO3-[s] + S-glutathionyl-2-4-dinitrobenzene[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_5581","Transport reactions","NA",-1000,-1000,"citrulline[c] + lysine[s] <=> citrulline[s] + lysine[c]","ENSG00000103064 or ENSG00000103257"]
["LKYNRtr2","Transport reactions",1000,-137.7268295909,-472.1697864677,"phenylalanine[c] + kynurenine[s] <=> kynurenine[c] + phenylalanine[s]","ENSG00000092068"]
["HMR_5586","Transport reactions",-1000,1000,"NA","citrulline[c] + histidine[s] <=> citrulline[s] + histidine[c]","ENSG00000103064 or ENSG00000103257"]
["PMTCRNte","Transport reactions",1000,"NA",800.1942705062,"L-palmitoylcarnitine[c] + Na+[c] => Na+[s] + L-palmitoylcarnitine[s]","ENSG00000197375"]
["HMR_6049","Transport reactions",1000,-1000,-1000,"L-lactate[c] + retinoate[s] <=> L-lactate[s] + retinoate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["CITtam","Transport reactions","NA","NA",1000,"citrate[c] + malate[m] <=> citrate[m] + malate[c]","ENSG00000100075"]
["HMR_7839","Transport reactions","NA",888.9884598999,"NA","dATP[c] + dUDP[m] => dATP[m] + dUDP[c]","ENSG00000125454"]
["HMR_5866","Transport reactions","NA","NA",1000,"citrulline[c] + Na+[s] + tyrosine[s] => citrulline[s] + Na+[c] + tyrosine[c]","ENSG00000103064"]
["HMR_4985","Transport reactions","NA",1000,"NA","guanine[c] <=> guanine[s]","ENSG00000174669"]
["HMR_5843","Transport reactions","NA",728.0127038,"NA","arginine[c] + Na+[s] + serine[s] => arginine[s] + Na+[c] + serine[c]","ENSG00000103064"]
["HMR_4949","Transport reactions",-307.8192560932,1000,1000,"urea[c] <=> urea[s]","ENSG00000103569 or ENSG00000132874 or ENSG00000141469"]
["HMR_5536","Transport reactions",-1000,-1000,1000,"phenylalanine[c] + proline[s] <=> phenylalanine[s] + proline[c]","ENSG00000103257 or ENSG00000165029"]
["HMR_4928","Transport reactions",649.8284152379,"NA","NA","H+[s] + pyruvate[s] => H+[c] + pyruvate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["CE1918te","Transport reactions","NA",338.4899238488,"NA","AKG[c] + 5-hydroxytryptophol[s] <=> 5-hydroxytryptophol[c] + AKG[s]","ENSG00000149452 or ENSG00000197901"]
["HMR_4874","Transport reactions",590.6107319519,1000,-667.3658176295,"NH3[c] <=> NH3[m]"]
["HMR_5580","Transport reactions",-1000,1000,1000,"histidine[c] + lysine[s] <=> histidine[s] + lysine[c]","ENSG00000103064 or ENSG00000103257"]
["HMR_1898","Transport reactions","NA",1000,"NA","glutathionyl-leukotriene C4[c] + HCO3-[c] + noradrenaline[s] <=> glutathionyl-leukotriene C4[s] + HCO3-[s] + noradrenaline[c]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_5547","Transport reactions","NA",-1000,-1000,"threonine[c] + tyrosine[s] <=> threonine[s] + tyrosine[c]","ENSG00000103257 or ENSG00000188687"]
["HMR_0155","Transport reactions","NA",1000,"NA","butyrate[s] <=> butyrate[c]","ENSG00000113396 or ENSG00000121769 or ENSG00000130304 or ENSG00000135218 or ENSG00000143554 or ENSG00000145384 or ENSG00000163586 or ENSG00000164434 or ENSG00000164687 or ENSG00000167114 or ENSG00000170231 or ENSG00000170323 or ENSG00000197416 or ENSG00000205186"]
["HMR_5328","Transport reactions","NA","NA",264.7590702,"aspartate[s] + Na+[s] => aspartate[c] + Na+[c]","ENSG00000079215 or ENSG00000105143 or ENSG00000106688 or ENSG00000110436 or ENSG00000178537"]
["HMR_1903","Transport reactions","NA",-1000,-1000,"HCO3-[c] + serotonin[s] + S-glutathionyl-ethacrynic acid[c] <=> HCO3-[s] + serotonin[c] + S-glutathionyl-ethacrynic acid[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["FDPte","Transport reactions",-1000,"NA",-348.5912800842,"fructose-1,6-bisphosphate[c] <=> fructose-1,6-bisphosphate[s]"]
["HMR_3916","Transport reactions","NA",791.5742648436,507.5679530585,"5-methyl-THF[c] <=> 5-methyl-THF[s]","ENSG00000110195 or ENSG00000110203"]
["HMR_5007","Transport reactions","NA","NA",106.8811120892,"folate[s] => folate[c]","ENSG00000110195 or ENSG00000110203 or ENSG00000165457"]
["HMR_6044","Transport reactions",-1000,831.9750038724,-1000,"propanoate[c] + retinoate[s] <=> propanoate[s] + retinoate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_1909","Transport reactions","NA",1000,-1000,"dopamine[s] + HCO3-[c] + S-glutathionyl-ethacrynic acid[c] <=> dopamine[c] + HCO3-[s] + S-glutathionyl-ethacrynic acid[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["THFt2","Transport reactions",-1000,"NA","NA","H2O[c] + THF[s] <=> H2O[s] + THF[c]","ENSG00000173638"]
["HMR_5473","Transport reactions",-938.24660675,-271.9872962,145.6915974356,"alanine[c] + glutamine[s] <=> alanine[s] + glutamine[c]","ENSG00000103257 or ENSG00000130876 or ENSG00000168003"]
["HMR_5296","Transport reactions","NA","NA",-199.8057294938,"methanol[c] <=> methanol[s]"]
["HMR_6336","Transport reactions",102.3550212444,"NA",840.84808931,"ADP[m] + dGDP[c] => ADP[c] + dGDP[m]","ENSG00000125454"]
["HMR_5091","Transport reactions",1000,"NA","NA","threonine[s] => threonine[c]","(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"]
["C51CRNtr","Transport reactions","NA","NA",1000,"Tiglyl Carnitine[s] <=> Tiglyl Carnitine[c]"]
["HMR_6022","Transport reactions",1000,-1000,-1000,"acetate[s] + AKG[c] <=> acetate[c] + AKG[s]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_6530","Transport reactions","NA",169.2449619244,"NA","chloride[s] + 2 sulfate[c] => chloride[c] + 2 sulfate[s]","ENSG00000225697"]
["HMR_4919","Transport reactions",-148.7887816601,1000,1000,"CO2[c] <=> CO2[s]"]
["HMR_6018","Transport reactions",-1000,-872.8035964825,"NA","L-lactate[c] + pyruvate[s] <=> L-lactate[s] + pyruvate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_6010","Transport reactions",478.0404899277,1000,"NA","2-hydroxybutyrate[c] + propanoate[s] <=> 2-hydroxybutyrate[s] + propanoate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["ASPPROASCT1","Transport reactions",155.8570612,"NA","NA","aspartate[s] + Na+[s] + proline[c] => aspartate[c] + Na+[c] + proline[s]","ENSG00000115902"]
["HMR_5124","Transport reactions","NA","NA",502.3156583459,"glycine[c] <=> glycine[m]","ENSG00000144659"]
["HMR_7824","Transport reactions",-1000,-1000,"NA","dCDP[m] + dGDP[c] <=> dCDP[c] + dGDP[m]","ENSG00000125454"]
["BETBGTtc","Transport reactions",-19.1468509448,"NA",-1000,"betaine[s] + chloride[s] + Na+[s] <=> betaine[c] + chloride[c] + Na+[c]","ENSG00000111181"]
["HMR_6333","Transport reactions","NA",888.9884598999,"NA","ATP[m] + dGDP[c] => ATP[c] + dGDP[m]","ENSG00000125454"]
["HMR_6382","Transport reactions",124.19935625,"NA","NA","asparagine[s] + H+[c] + Na+[s] => asparagine[c] + H+[s] + Na+[c]","ENSG00000017483 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000268104"]
["ACRNte","Transport reactions",-819.8503006277,188.7274335591,1000,"Na+[c] + O-acetylcarnitine[c] <=> Na+[s] + O-acetylcarnitine[s]","ENSG00000197375"]
["HMR_5458","Transport reactions",1000,271.9872962,-102.2497953974,"alanine[c] + glycine[s] <=> alanine[s] + glycine[c]","ENSG00000103257 or ENSG00000130876 or ENSG00000168003"]
["HMR_6007","Transport reactions",1000,"NA",1000,"2-hydroxybutyrate[c] + pyruvate[s] <=> 2-hydroxybutyrate[s] + pyruvate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_4691","Transport reactions",990.4265745276,"NA",686.9887849138,"4-aminobutyrate[s] + 2 Na+[s] => 4-aminobutyrate[c] + 2 Na+[c]","ENSG00000010379 or ENSG00000111181 or ENSG00000132164 or ENSG00000157103"]
["HMR_5684","Transport reactions",844.1429388,425.8437551273,"NA","cysteine[c] + Na+[s] + phenylalanine[s] => cysteine[s] + Na+[c] + phenylalanine[c]","ENSG00000103064"]
["HMR_5533","Transport reactions",-1000,"NA",-1000,"phenylalanine[c] + tyrosine[s] <=> phenylalanine[s] + tyrosine[c]","ENSG00000103257 or ENSG00000165029"]
["HMR_8861","Transport reactions",307.8192560932,-1000,-1000,"H2O[c] + urea[c] <=> H2O[s] + urea[s]","ENSG00000132874 or ENSG00000141469"]
["HMR_6038","Transport reactions",-1000,1000,-1000,"formate[s] + L-lactate[c] <=> formate[c] + L-lactate[s]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_5430","Transport reactions",441.0305583329,"NA","NA","H+[c] + Na+[s] => H+[s] + Na+[c]","ENSG00000066230 or ENSG00000090020 or ENSG00000115616 or ENSG00000135740 or ENSG00000180251 or ENSG00000181804"]
["HMR_5070","Transport reactions",1000,-1000,-1000,"histidine[c] <=> histidine[s]","(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703"]
["HMR_6045","Transport reactions",1000,1000,"NA","(R)-3-hydroxybutanoate[c] + propanoate[s] <=> (R)-3-hydroxybutanoate[s] + propanoate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_7814","Transport reactions",-1000,1000,-1000,"dCDP[c] + dUDP[m] <=> dCDP[m] + dUDP[c]","ENSG00000125454"]
["TDCHOLAte","Transport reactions","NA","NA",13.0606185,"taurochenodeoxycholate[s] <=> taurochenodeoxycholate[c]"]
["HMR_5639","Transport reactions","NA","NA",418.5998126177,"cysteine[c] + Na+[s] + serine[s] => cysteine[s] + Na+[c] + serine[c]","ENSG00000103064 or ENSG00000105281 or ENSG00000115902"]
["RETINALt","Transport reactions",321.8657383,-168.0249961276,"NA","retinal[c] <=> retinal[s]"]
["HMR_5664","Transport reactions","NA",728.0127038,"NA","glutamine[c] + Na+[s] + tryptophan[s] => glutamine[s] + Na+[c] + tryptophan[c]","ENSG00000103064 or ENSG00000103257"]
["HMR_8676","Transport reactions",819.8503006277,-188.7274335591,-1000,"L-carnitine[c] <=> L-carnitine[s]","ENSG00000197208 or ENSG00000197375"]
["HMR_7810","Transport reactions",1000,-888.9884598999,"NA","dGDP[c] + dUDP[m] <=> dGDP[m] + dUDP[c]","ENSG00000125454"]
["HMR_5006","Transport reactions","NA","NA",502.3156583459,"folate[c] => folate[m]"]
["HMR_1906","Transport reactions","NA",-1000,-1000,"acetylcholine[s] + HCO3-[c] + S-glutathionyl-ethacrynic acid[c] <=> acetylcholine[c] + HCO3-[s] + S-glutathionyl-ethacrynic acid[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_6369","Transport reactions",1000,"NA",1000,"deoxyinosine[c] => deoxyinosine[s]","ENSG00000112759 or ENSG00000174669"]
["HMR_8340","Transport reactions","NA","NA",-666.6666666667,"L-arabinose[c] <=> L-arabinose[s]"]
["HDD2CRNte2","Transport reactions","NA","NA",1000,"Na+[s] + hexadecenoylcarnitine(9)[s] => hexadecenoylcarnitine(9)[c] + Na+[c]","ENSG00000105281 or ENSG00000197375"]
["HMR_6026","Transport reactions",-1000,-1000,40.2740436901,"AKG[c] + L-lactate[s] <=> AKG[s] + L-lactate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["ALAyLATthc","Transport reactions","NA","NA",56.5024205382,"alanine[s] + arginine[c] + H+[s] => alanine[c] + arginine[s] + H+[c]","(ENSG00000103064 and ENSG00000168003) or (ENSG00000155465 and ENSG00000168003)"]
["HMR_7638","Transport reactions","NA",288.0236399319,"NA","H+[c] => H+[m]","ENSG00000102078 or ENSG00000109424 or ENSG00000153291 or ENSG00000175564 or ENSG00000175567"]
["PCRNte","Transport reactions","NA","NA",1000,"Na+[c] + O-propanoylcarnitine[c] => Na+[s] + O-propanoylcarnitine[s]","ENSG00000197375"]
["HMR_5585","Transport reactions",-1000,1000,943.4975794618,"histidine[c] + ornithine[s] <=> histidine[s] + ornithine[c]","ENSG00000103064 or ENSG00000103257"]
["DHAPtr","Transport reactions","NA",-845.4652523749,"NA","DHAP[s] <=> DHAP[c]"]
["HMR_5122","Transport reactions","NA",295.1429371045,278.0550003599,"glutamate[c] + H+[c] => glutamate[m] + H+[m]","ENSG00000177542 or ENSG00000182902"]
["C4tmc","Transport reactions","NA",-211.1420532705,"NA","O-butanoylcarnitine[c] <=> O-butanoylcarnitine[m]","ENSG00000178537"]
["HMR_1899","Transport reactions","NA","NA",-1000,"HCO3-[c] + noradrenaline[s] + S-glutathionyl-2-4-dinitrobenzene[c] <=> HCO3-[s] + noradrenaline[c] + S-glutathionyl-2-4-dinitrobenzene[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1900","Transport reactions","NA",-1000,1000,"HCO3-[c] + noradrenaline[s] + S-glutathionyl-ethacrynic acid[c] <=> HCO3-[s] + noradrenaline[c] + S-glutathionyl-ethacrynic acid[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_1904","Transport reactions","NA",1000,1000,"acetylcholine[s] + glutathionyl-leukotriene C4[c] + HCO3-[c] <=> acetylcholine[c] + glutathionyl-leukotriene C4[s] + HCO3-[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["ARGtm","Transport reactions","NA",1000,1000,"arginine[c] + H+[m] <=> arginine[m] + H+[c]","ENSG00000102743 or ENSG00000120329"]
["PHPYRtm","Transport reactions","NA",-987.43001925,"NA","H+[m] + phenylpyruvate[m] <=> H+[c] + phenylpyruvate[c]","ENSG00000060762 and ENSG00000143158"]
["HMR_4926","Transport reactions",327.9626769379,"NA","NA","H+[c] + pyruvate[c] => H+[m] + pyruvate[m]","ENSG00000060762 or ENSG00000143158 or ENSG00000238205"]
["HDCECRNte","Transport reactions","NA","NA",199.8057294938,"Na+[c] + palmitoleoyl-carnitine[c] => Na+[s] + palmitoleoyl-carnitine[s]","ENSG00000197375"]
["PEPtr","Transport reactions",1000,"NA","NA","HCO3-[s] + PEP[c] <=> HCO3-[c] + PEP[s]"]
["HMR_5777","Transport reactions","NA","NA",1000,"Na+[s] + proline[c] + valine[s] => Na+[c] + proline[s] + valine[c]","ENSG00000103064"]
["HMR_4957","Transport reactions",32.657310962,"NA",165.0501592836,"citrate[m] => citrate[c]"]
["HMR_4321","Transport reactions",-183.2085838564,"NA",-11.03078225,"fructose[c] <=> fructose[s]","ENSG00000109667 or ENSG00000133460 or ENSG00000136856 or ENSG00000142583 or ENSG00000163581 or ENSG00000197241"]
["HMR_4964","Transport reactions","NA","NA",1000,"citrate[m] + H+[m] + malate[c] => citrate[c] + H+[c] + malate[m]","ENSG00000100075"]
["HMR_4914","Transport reactions",1000,788.8579467295,"NA","CoA[c] <=> CoA[m]","ENSG00000122912 or ENSG00000181035"]
["HMR_4898","Transport reactions","NA","NA",1000,"O2[c] <=> O2[m]"]
["HMR_6034","Transport reactions",1000,-1000,-1000,"acetate[c] + butyrate[s] <=> acetate[s] + butyrate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["NAHCO3_HCLt","Transport reactions",-1000,423.6377689594,110.6169350382,"chloride[c] + H+[c] + HCO3-[s] + Na+[s] <=> chloride[s] + H+[s] + HCO3-[c] + Na+[c]","ENSG00000050438 or ENSG00000144290"]
["ICITtr","Transport reactions",147.4923884103,"NA","NA","isocitrate[s] <=> isocitrate[c]"]
["HMR_5527","Transport reactions",-1000,-728.0127038,"NA","proline[c] + tryptophan[s] <=> proline[s] + tryptophan[c]","ENSG00000103257 or ENSG00000165029"]
["HMR_5037","Transport reactions",1000,-438.943605725,1000,"guanosine[c] <=> guanosine[s]","ENSG00000112759 or ENSG00000174669"]
["HMR_1907","Transport reactions","NA","NA",1000,"dopamine[s] + glutathionyl-leukotriene C4[c] + HCO3-[c] <=> dopamine[c] + glutathionyl-leukotriene C4[s] + HCO3-[s]","ENSG00000021488 or ENSG00000084453 or ENSG00000111700"]
["HMR_5996","Transport reactions","NA","NA",47.5709835895,"citrate[s] + 3 Na+[s] => citrate[c] + 3 Na+[c]","ENSG00000103064 or ENSG00000158296"]
["HMR_8586","Transport reactions","NA","NA",-327.8179422083,"maltose[c] <=> maltose[s]","ENSG00000059804"]
["HMR_6035","Transport reactions",-1000,-1000,1000,"acetate[c] + retinoate[s] <=> acetate[s] + retinoate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_5470","Transport reactions",-1000,"NA",-1000,"glycine[c] + threonine[s] <=> glycine[s] + threonine[c]","ENSG00000103257 or ENSG00000130876 or ENSG00000168003"]
["HMR_7806","Transport reactions",-1000,-1000,159.15191069,"dADP[m] + dGDP[c] <=> dADP[c] + dGDP[m]","ENSG00000125454"]
["HMR_5432","Transport reactions","NA",423.6377689594,123.6775535382,"HCO3-[c] + Na+[c] => HCO3-[s] + Na+[s]","ENSG00000033867"]
["HMR_6048","Transport reactions",-1000,-1000,1000,"butyrate[s] + L-lactate[c] <=> butyrate[c] + L-lactate[s]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["r0946","Transport reactions","NA",-1000,-1000,"citrulline[c] + ornithine[s] <=> citrulline[s] + ornithine[c]","ENSG00000021488"]
["HMR_5497","Transport reactions",-1000,-1000,"NA","glutamine[c] + threonine[s] <=> glutamine[s] + threonine[c]","ENSG00000103257 or ENSG00000130876 or ENSG00000168003"]
["HMR_6023","Transport reactions",1000,-1000,174.8981952731,"AKG[c] + formate[s] <=> AKG[s] + formate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_6025","Transport reactions",-1000,1000,-1000,"acetoacetate[s] + AKG[c] <=> acetoacetate[c] + AKG[s]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["HMR_5895","Transport reactions",1000,"NA","NA","histidine[c] + Na+[s] + threonine[s] => histidine[s] + Na+[c] + threonine[c]","ENSG00000103064"]
["HMR_6024","Transport reactions",-478.0404899277,831.9750038724,1000,"AKG[c] + propanoate[s] <=> AKG[s] + propanoate[c]","ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190"]
["ACRNtm","Transport reactions",1000,422.2841065409,-563.2751812151,"O-acetylcarnitine[c] <=> O-acetylcarnitine[m]","ENSG00000178537"]
["HMR_6384","Transport reactions",704.6946340241,"NA","NA","H+[c] + histidine[s] + Na+[s] => H+[s] + histidine[c] + Na+[c]","ENSG00000017483 or ENSG00000134294 or ENSG00000268104"]
["LKYNRtr","Transport reactions",-1000,137.7268295909,472.1697864677,"kynurenine[s] <=> kynurenine[c]","ENSG00000149150 or ENSG00000167703"]
["HMR_9604","Transport reactions",9.5734254724,"NA","NA","4-aminobutyrate[s] + 2 chloride[s] + 3 Na+[s] => 4-aminobutyrate[c] + 2 chloride[c] + 3 Na+[c]","ENSG00000111181"]
["HMR_5008","Transport reactions","NA",561.056394275,-677.779358012,"deoxyuridine[c] <=> deoxyuridine[s]","ENSG00000112759 or ENSG00000174669"]
["HMR_8917","Transport reactions",1000,"NA","NA","lysine[s] + Na+[s] => lysine[c] + Na+[c]","ENSG00000197375 or ENSG00000268104"]
["HMR_7812","Transport reactions","NA",-1000,1000,"dADP[c] + dUDP[m] <=> dADP[m] + dUDP[c]","ENSG00000125454"]
["HMR_3950","Transport reactions","NA","NA",-502.3156583459,"5,10-methylene-THF[c] <=> 5,10-methylene-THF[m]"]
["TREt","Transport reactions","NA",182.896178075,"NA","trehalose[s] <=> trehalose[c]"]
["GABABGTtc","Transport reactions",-1000,"NA",-686.9887849138,"4-aminobutyrate[s] + chloride[s] + Na+[s] <=> 4-aminobutyrate[c] + chloride[c] + Na+[c]","ENSG00000111181"]
["HMR_1620","Transport reactions",104.3268690731,295.1429371045,"NA","3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[c] <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[m]","ENSG00000083807 or ENSG00000140284"]
["5HOXINDOAtr","Transport reactions","NA",-338.4899238488,"NA","sulfate[c] + 5-hydroxyindoleacetate[s] <=> 5-hydroxyindoleacetate[c] + sulfate[s]","ENSG00000004939"]
["HMR_7842","Transport reactions",1000,"NA",1000,"dCTP[c] + dUDP[m] => dCTP[m] + dUDP[c]","ENSG00000125454"]
["HMR_4456","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",-32.657310962,-436.4294152818,1000,"citrate[m] <=> isocitrate[m]","ENSG00000100412 or ENSG00000122729"]
["HMR_4149","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",180.1496993723,"NA",212.6211428731,"ATP[c] + citrate[c] + CoA[c] => acetyl-CoA[c] + ADP[c] + OAA[c] + Pi[c]","ENSG00000131473"]
["HMR_4454","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",-147.4923884103,"NA","NA","citrate[c] <=> isocitrate[c]","ENSG00000122729 or ENSG00000136381"]
["HMR_4458","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",-1000,-1000,671.8229199605,"cis-aconitate[m] + H2O[m] <=> citrate[m]","ENSG00000100412 or ENSG00000122729"]
["HMR_3957","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism","NA","NA",328.1770800395,"isocitrate[m] + NAD+[m] => AKG[m] + CO2[m] + NADH[m]","ENSG00000067829 or ENSG00000101365 or ENSG00000166411"]
["HMR_4112","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",967.342689038,"NA","NA","H+[m] + oxalosuccinate[m] => AKG[m] + CO2[m]","ENSG00000138413 or ENSG00000182054"]
["HMR_3958","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism","NA",563.5705847182,"NA","isocitrate[m] + NADP+[m] => AKG[m] + CO2[m] + NADPH[m]","ENSG00000138413 or ENSG00000182054"]
["HMR_4410","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",-219.6163914102,137.7268295909,-499.1254879166,"fumarate[m] + H2O[m] <=> malate[m]","ENSG00000091483"]
["HMR_4589","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",1000,1000,-671.8229199605,"cis-aconitate[m] + H2O[m] <=> isocitrate[m]","ENSG00000100412 or ENSG00000122729"]
["HMR_4139","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",-71.6695581111,3.5596485863,1000,"H+[c] + NADH[c] + OAA[c] <=> malate[c] + NAD+[c]","ENSG00000014641 or ENSG00000138400"]
["RE2426C","Tryptophan metabolism",-1000,"NA","NA","H2O[c] + melatonin[c] <=> 6-hydroxymelatonin[c] + 2 H+[c]"]
["HMR_8566","Tryptophan metabolism",1000,"NA","NA","H+[c] + melatonin[c] + NADPH[c] + O2[c] => 6-hydroxymelatonin[c] + H2O[c] + NADP+[c]","ENSG00000138061 or ENSG00000140465 or ENSG00000140505 or ENSG00000165841"]
["HMR_3935","Tyrosine metabolism",-1000,1000,-800.1942705062,"formaldehyde[c] + GSH[c] <=> hydroxymethylglutathione[c]","ENSG00000117305"]
["HMR_8530","Tyrosine metabolism",1000,-1000,1000,"formaldehyde[c] + GSH[c] + NAD+[c] <=> formylglutathione[c] + H+[c] + NADH[c]","ENSG00000147576 or ENSG00000172955 or ENSG00000187758 or ENSG00000196344 or ENSG00000196616 or ENSG00000197894 or ENSG00000198099 or ENSG00000248144"]
["HMR_4687","Tyrosine metabolism",774.3923443065,"NA","NA","2 H+[m] + NADPH[m] + phenylacetate[m] <=> H2O[m] + NADP+[m] + phenylacetaldehyde[m]","ENSG00000006534 or ENSG00000108602 or ENSG00000132746 or ENSG00000184254"]
["HMR_4685","Tyrosine metabolism",774.3923443065,"NA","NA","H2O[m] + NAD+[m] + phenylacetaldehyde[m] => 2 H+[m] + NADH[m] + phenylacetate[m]","ENSG00000006534 or ENSG00000108602 or ENSG00000132746 or ENSG00000184254"]
["HMR_3796","Valine, leucine, and isoleucine metabolism",-1000,-1000,1000,"AMP[m] + H+[m] + propanoyl-CoA[m] <=> CoA[m] + propinol adenylate[m]","ENSG00000111058 or ENSG00000131069 or ENSG00000154930"]
["HMR_3785","Valine, leucine, and isoleucine metabolism","NA","NA",1000,"H2O[m] + tiglyl-CoA[m] => (S)-3-hydroxy-2-methylbutyryl-CoA[m]","ENSG00000084754 and ENSG00000113790 and ENSG00000127884"]
["HMR_3751","Valine, leucine, and isoleucine metabolism",211.8312062398,1000,"NA","isobutyryl-CoA[m] + ubiquinone[m] => methacrylyl-CoA[m] + ubiquinol[m]","ENSG00000122971 or ENSG00000196177"]
["HMR_3206","Valine, leucine, and isoleucine metabolism","NA","NA",1000,"2-methylacetoacetyl-CoA[m] + CoA[m] => acetyl-CoA[m] + propanoyl-CoA[m]","ENSG00000084754 and ENSG00000138029 and ENSG00000167315"]
["HMR_3823","Valine, leucine, and isoleucine metabolism","NA","NA",1000,"(S)-3-hydroxy-2-methylbutyryl-CoA[m] + NAD+[m] <=> 2-methylacetoacetyl-CoA[m] + H+[m] + NADH[m]","ENSG00000072506 or ENSG00000138796"]

{"sheet":"ART Unique Reactions","index":1,"n_rows":81,"n_cols":6,"rows_kept":81,"cut":false,"hidden":false,"merged":[]}
["RXN_ID","SubSystem","ART","EC","HC","EQN"]
["HMR_3829","Alanine, aspartate and glutamate metabolism",-251.8192574834,3.5596485863,787.3788571269,"AKG[c] + aspartate[c] <=> glutamate[c] + OAA[c]"]
["HMR_4300","Amino sugar and nucleotide sugar metabolism",61.75339325,0,0,"fructose-6-phosphate[c] + glutamine[c] => glucosamine-6-phosphate[c] + glutamate[c]"]
["HMR_4299","Amino sugar and nucleotide sugar metabolism",61.75339325,0,0,"glucosamine-6-phosphate[c] + H2O[c] => fructose-6-phosphate[c] + H+[c] + NH3[c]"]
["HMR_3956","Arginine and proline metabolism",327.9626769379,0,0,"CO2[m] + H2O[m] => H+[m] + HCO3-[m]"]
["RE1804M","Bile acid biosynthesis",-1000,0,0,"5beta-cholestane-3alpha,7alpha,26-triol[m] + NAD+[m] <=> 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADH[m]"]
["HMR_1685","Bile acid biosynthesis",1000,0,0,"5beta-cholestane-3alpha,7alpha,26-triol[m] + NADP+[m] => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADPH[m]"]
["HMR_2666","Carnitine shuttle (cytosolic)",-1000,1000,1000,"(9E)-octadecenoyl-CoA[c] + L-carnitine[c] <=> (9E)-octadecenoylcarnitine[c] + CoA[c]"]
["HMR_2655","Carnitine shuttle (mitochondrial)",-1000,1000,1000,"L-carnitine[c] + stearoylcarnitine[m] <=> L-carnitine[m] + stearoylcarnitine[c]"]
["HMR_0267","Fatty acid activation (cytosolic)",1000,-1000,-1000,"(9E)-octadecenoyl-CoA[c] + AMP[c] + PPi[c] <=> ATP[c] + CoA[c] + elaidate[c]"]
["HMR_0226","Fatty acid activation (cytosolic)",1000,0,0,"AMP[c] + palmitoleoyl-CoA[c] + PPi[c] <=> ATP[c] + CoA[c] + palmitolate[c]"]
["C180CRNt","Fatty acid oxidation",-1000,1000,1000,"stearoylcarnitine[c] <=> stearoylcarnitine[m]"]
["FACOAL1813","Fatty acid oxidation",1000,-1000,-1000,"ATP[c] + CoA[c] + elaidate[c] <=> (2E)-octadecenoyl-CoA[c] + AMP[c] + PPi[c]"]
["ELAIDCPT1","Fatty acid oxidation",1000,-1000,-1000,"(2E)-octadecenoyl-CoA[c] + L-carnitine[c] <=> (9E)-octadecenoylcarnitine[c] + CoA[c]"]
["r1252","Fatty acid oxidation",1000,0,0,"ATP[c] + CoA[c] + palmitolate[c] => AMP[c] + PPi[c] + (2E)-hexadecenoyl-CoA[c]"]
["C161CPT12","Fatty acid oxidation",1000,0,0,"L-carnitine[c] + (2E)-hexadecenoyl-CoA[c] <=> CoA[c] + hexadecenoylcarnitine(9)[c]"]
["HMR_7748","Glycolysis / Gluconeogenesis",-1000,1000,1000,"beta-D-glucose-6-phosphate[c] <=> glucose-6-phosphate[c]"]
["HMR_4355","Glycolysis / Gluconeogenesis",363.3582832287,0,0,"DHAP[c] + erythrose-4-phosphate[c] => sedoheptulose-1,7-bisphosphate[c]"]
["HMR_4381","Glycolysis / Gluconeogenesis",1000,-1000,-1000,"fructose-6-phosphate[c] <=> glucose-6-phosphate[c]"]
["HMR_7749","Glycolysis / Gluconeogenesis",1000,-1000,-333.3333333333,"beta-D-glucose-6-phosphate[c] <=> fructose-6-phosphate[c]"]
["HMR_8453","Nucleotide metabolism",-1000,1000,1000,"2 dCDP[n] <=> dCMP[n] + dCTP[n]"]
["HMR_7868","Nucleotide metabolism",-1000,1000,1000,"GDP[n] + UDP[n] <=> GTP[n] + UMP[n]"]
["HMR_7876","Nucleotide metabolism",-1000,1000,1000,"ADP[n] + UDP[n] <=> ATP[n] + UMP[n]"]
["HMR_8466","Nucleotide metabolism",-1000,1000,1000,"2 CDP[n] <=> CMP[n] + CTP[n]"]
["HMR_8455","Nucleotide metabolism",-1000,1000,1000,"dADP[n] + dCDP[n] <=> dATP[n] + dCMP[n]"]
["HMR_3967","Nucleotide metabolism",-1000,1000,836.9312687021,"CDP[c] + GDP[c] <=> CMP[c] + GTP[c]"]
["HMR_7800","Nucleotide metabolism",1000,-305.50577005,-1000,"ADP[c] + GDP[c] <=> AMP[c] + GTP[c]"]
["HMR_8472","Nucleotide metabolism",1000,-1000,-1000,"CDP[n] + dCDP[n] <=> CMP[n] + dCTP[n]"]
["HMR_7870","Nucleotide metabolism",1000,-1000,-1000,"dADP[n] + UDP[n] <=> dATP[n] + UMP[n]"]
["HMR_8459","Nucleotide metabolism",1000,-1000,-1000,"ADP[n] + dCDP[n] <=> ATP[n] + dCMP[n]"]
["HMR_7874","Nucleotide metabolism",1000,0,0,"dGDP[n] + UDP[n] <=> dGTP[n] + UMP[n]"]
["HMR_7864","Nucleotide metabolism",1000,0,0,"CDP[n] + UDP[n] <=> CTP[n] + UMP[n]"]
["HMR_8463","Nucleotide metabolism",1000,0,0,"CDP[c] + dCDP[c] <=> CTP[c] + dCMP[c]"]
["HMR_8462","Nucleotide metabolism",1000,0,0,"dCDP[n] + GDP[n] <=> dCMP[n] + GTP[n]"]
["HMR_6916","Oxidative phosphorylation",411.4368366741,0,0,"ADP[m] + Pi[m] + 3 H+[i] => ATP[m] + 2 H+[m] + H2O[m]"]
["HMR_4489","Purine metabolism",183.2085838564,0,0,"dATP[c] + fructose[c] => dADP[c] + fructose-6-phosphate[c] + H+[c]"]
["HMR_4016","Purine metabolism",1000,-690.3506859251,-1000,"ADP[c] + GTP[c] <=> ATP[c] + GDP[c]"]
["HMR_4006","Pyrimidine metabolism",363.3582832287,-1000,-1000,"ADP[c] + UTP[c] <=> ATP[c] + UDP[c]"]
["HMR_4143","Pyruvate metabolism",327.9626769379,0,0,"ATP[m] + HCO3-[m] + pyruvate[m] => ADP[m] + H+[m] + OAA[m] + Pi[m]"]
["HMR_8698","Retinol metabolism",321.8657383,0,0,"2 H+[c] + NADPH[c] + retinoate[c] <=> H2O[c] + NADP+[c] + retinal[c]"]
["HMR_0766","Sphingolipid metabolism",213.1499046274,0,0,"galactose[s] + glucosylceramide pool[s] => H2O[s] + LacCer pool[s]"]
["HMR_5580","Transport reactions",-1000,1000,1000,"histidine[c] + lysine[s] <=> histidine[s] + lysine[c]"]
["HMR_5585","Transport reactions",-1000,1000,943.4975794618,"histidine[c] + ornithine[s] <=> histidine[s] + ornithine[c]"]
["NAHCO3_HCLt","Transport reactions",-1000,423.6377689594,110.6169350382,"chloride[c] + H+[c] + HCO3-[s] + Na+[s] <=> chloride[s] + H+[s] + HCO3-[c] + Na+[c]"]
["LKYNRtr","Transport reactions",-1000,137.7268295909,472.1697864677,"kynurenine[s] <=> kynurenine[c]"]
["THFt2","Transport reactions",-1000,0,0,"H2O[c] + THF[s] <=> H2O[s] + THF[c]"]
["ACRNte","Transport reactions",-819.8503006277,188.7274335591,1000,"Na+[c] + O-acetylcarnitine[c] <=> Na+[s] + O-acetylcarnitine[s]"]
["HMR_6024","Transport reactions",-478.0404899277,831.9750038724,1000,"AKG[c] + propanoate[s] <=> AKG[s] + propanoate[c]"]
["HMR_4949","Transport reactions",-307.8192560932,1000,1000,"urea[c] <=> urea[s]"]
["HMR_4919","Transport reactions",-148.7887816601,1000,1000,"CO2[c] <=> CO2[s]"]
["HMR_9604","Transport reactions",9.5734254724,0,0,"4-aminobutyrate[s] + 2 chloride[s] + 3 Na+[s] => 4-aminobutyrate[c] + 2 chloride[c] + 3 Na+[c]"]
["HMR_9605","Transport reactions",61.75339325,0,0,"alanine[s] + H+[c] + Na+[s] => alanine[c] + H+[s] + Na+[c]"]
["HMR_6382","Transport reactions",124.19935625,0,0,"asparagine[s] + H+[c] + Na+[s] => asparagine[c] + H+[s] + Na+[c]"]
["ICITtr","Transport reactions",147.4923884103,0,0,"isocitrate[s] <=> isocitrate[c]"]
["HMR_5745","Transport reactions",155.8570612,0,0,"cysteine[c] + Na+[s] + proline[s] => cysteine[s] + Na+[c] + proline[c]"]
["ASPPROASCT1","Transport reactions",155.8570612,0,0,"aspartate[s] + Na+[s] + proline[c] => aspartate[c] + Na+[c] + proline[s]"]
["HMR_8861","Transport reactions",307.8192560932,-1000,-1000,"H2O[c] + urea[c] <=> H2O[s] + urea[s]"]
["HMR_4926","Transport reactions",327.9626769379,0,0,"H+[c] + pyruvate[c] => H+[m] + pyruvate[m]"]
["HMR_5430","Transport reactions",441.0305583329,0,0,"H+[c] + Na+[s] => H+[s] + Na+[c]"]
["HMR_4928","Transport reactions",649.8284152379,0,0,"H+[s] + pyruvate[s] => H+[c] + pyruvate[c]"]
["HMR_6384","Transport reactions",704.6946340241,0,0,"H+[c] + histidine[s] + Na+[s] => H+[s] + histidine[c] + Na+[c]"]
["HMR_8676","Transport reactions",819.8503006277,-188.7274335591,-1000,"L-carnitine[c] <=> L-carnitine[s]"]
["LKYNRtr2","Transport reactions",1000,-137.7268295909,-472.1697864677,"phenylalanine[c] + kynurenine[s] <=> kynurenine[c] + phenylalanine[s]"]
["HMR_6049","Transport reactions",1000,-1000,-1000,"L-lactate[c] + retinoate[s] <=> L-lactate[s] + retinoate[c]"]
["HMR_6022","Transport reactions",1000,-1000,-1000,"acetate[s] + AKG[c] <=> acetate[c] + AKG[s]"]
["HMR_5070","Transport reactions",1000,-1000,-1000,"histidine[c] <=> histidine[s]"]
["HMR_6034","Transport reactions",1000,-1000,-1000,"acetate[c] + butyrate[s] <=> acetate[s] + butyrate[c]"]
["HMR_5662","Transport reactions",1000,0,0,"glycine[c] + Na+[s] + tryptophan[s] => glycine[s] + Na+[c] + tryptophan[c]"]
["HDCECRNtr","Transport reactions",1000,0,0,"palmitoleoyl-carnitine[s] <=> palmitoleoyl-carnitine[c]"]
["HMR_5448","Transport reactions",1000,0,0,"HCO3-[c] + 2 Na+[c] => HCO3-[s] + 2 Na+[s]"]
["HMR_5091","Transport reactions",1000,0,0,"threonine[s] => threonine[c]"]
["PEPtr","Transport reactions",1000,0,0,"HCO3-[s] + PEP[c] <=> HCO3-[c] + PEP[s]"]
["HMR_5895","Transport reactions",1000,0,0,"histidine[c] + Na+[s] + threonine[s] => histidine[s] + Na+[c] + threonine[c]"]
["HMR_8917","Transport reactions",1000,0,0,"lysine[s] + Na+[s] => lysine[c] + Na+[c]"]
["HMR_4454","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",-147.4923884103,0,0,"citrate[c] <=> isocitrate[c]"]
["HMR_4139","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",-71.6695581111,3.5596485863,1000,"H+[c] + NADH[c] + OAA[c] <=> malate[c] + NAD+[c]"]
["HMR_4112","Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism",967.342689038,0,0,"H+[m] + oxalosuccinate[m] => AKG[m] + CO2[m]"]
["RE2426C","Tryptophan metabolism",-1000,0,0,"H2O[c] + melatonin[c] <=> 6-hydroxymelatonin[c] + 2 H+[c]"]
["HMR_8566","Tryptophan metabolism",1000,0,0,"H+[c] + melatonin[c] + NADPH[c] + O2[c] => 6-hydroxymelatonin[c] + H2O[c] + NADP+[c]"]
["HMR_4687","Tyrosine metabolism",774.3923443065,0,0,"2 H+[m] + NADPH[m] + phenylacetate[m] <=> H2O[m] + NADP+[m] + phenylacetaldehyde[m]"]
["HMR_4685","Tyrosine metabolism",774.3923443065,0,0,"H2O[m] + NAD+[m] + phenylacetaldehyde[m] => 2 H+[m] + NADH[m] + phenylacetate[m]"]