Position,Substitution,Effect.median,Effect.lower,Effect.upper
2,L2Q,0.36,0.32,0.39
2,Q2L,0.38,0.33,0.42
2,L2H,0.75,0.71,0.8
2,H2L,0.76,0.71,0.81
4,S4R,0.63,0.38,0.93
4,E4S,0.63,0.56,0.71
4,R4S,0.65,0.41,0.91
4,R4T,0.66,0.63,0.73
4,T4R,0.66,0.62,0.76
4,S4E,0.69,0.61,0.77
4,Q4A,0.82,0.75,0.92
4,A4Q,0.85,0.75,0.91
4,K4A,0.96,0.88,1.05
4,A4K,0.97,0.87,1.05
4,E4A,1.02,0.96,1.1
4,A4E,1.04,0.96,1.11
5,V5M,0.25,0.19,0.31
5,M5V,0.26,0.2,0.32
7,N7A,0.28,0.23,0.34
7,S7A,0.29,0.24,0.35
7,A7N,0.29,0.24,0.34
7,A7S,0.3,0.25,0.36
10,T10M,0.72,0.69,0.76
10,M10T,0.79,0.75,0.83
12,A12V,0.26,0.21,0.3
12,V12A,0.27,0.22,0.31
19,V19I,0.08,0.04,0.11
19,M19I,0.15,0.09,0.18
19,I19M,0.16,0.12,0.2
19,F19L,0.2,0.16,0.24
19,L19F,0.2,0.15,0.23
19,F19V,0.24,0.21,0.28
19,L19V,0.27,0.23,0.3
19,V19F,0.3,0.27,0.33
19,V19L,0.32,0.28,0.35
19,M19V,1.01,0.95,1.07
19,V19M,1.09,1.03,1.14
27,I27F,0.73,0.65,0.82
27,F27I,0.73,0.63,0.81
27,W27I,1.19,1.1,1.3
27,I27W,1.2,1.1,1.28
28,N28S,1.26,0.91,1.41
28,S28N,1.28,0.93,1.43
29,K29M,0.57,0.48,0.66
29,M29K,0.58,0.49,0.66
29,M29R,0.79,0.73,0.87
29,R29M,0.79,0.69,0.87
33,I33T,0.15,0.1,0.18
33,T33I,0.16,0.12,0.21
33,V33I,0.34,0.26,0.42
33,I33V,0.37,0.26,0.45
34,T34V,0.81,0.75,0.87
34,V34T,0.83,0.77,0.89
36,A36T,0.27,0.23,0.32
36,T36A,0.29,0.25,0.34
37,M37L,0.28,0.25,0.31
37,L37M,0.31,0.24,0.36
37,M37V,0.5,0.45,0.56
37,V37M,0.53,0.47,0.59
37,M37F,0.89,0.8,1.24
37,F37M,0.94,0.8,1.39
38,F38V,0.15,0.13,0.18
38,V38F,0.16,0.13,0.18
38,T38V,0.18,0.15,0.2
38,V38T,0.19,0.16,0.21
38,F38T,0.26,0.2,0.32
38,T38F,0.27,0.2,0.31
38,S38A,0.41,0.34,0.49
38,A38S,0.44,0.35,0.51
38,T38I,0.44,0.38,0.49
38,I38T,0.44,0.37,0.49
38,I38F,0.68,0.6,0.75
38,F38I,0.7,0.61,0.78
38,S38I,1.24,0.7,1.69
38,I38S,1.32,0.81,1.76
38,S38F,1.7,1.63,1.8
38,F38S,1.71,1.63,1.78
38,S38T,2.3,2.2,2.37
38,T38S,2.36,2.24,2.44
41,C41M,0.14,0.06,0.23
41,M41C,0.14,0.07,0.23
41,F41M,0.22,0.11,0.34
41,M41F,0.24,0.14,0.38
41,L41V,0.25,0.22,0.29
41,V41L,0.26,0.23,0.29
41,C41L,0.42,0.39,0.46
41,L41C,0.42,0.39,0.45
41,L41M,0.51,0.38,0.65
41,M41L,0.52,0.35,0.7
44,V44I,0.06,0.01,0.09
44,L44T,0.51,0.45,0.59
44,T44L,0.52,0.45,0.58
45,M45V,0.18,0.11,0.24
45,V45M,0.19,0.12,0.25
45,V45T,0.32,0.26,0.38
45,T45V,0.32,0.25,0.39
45,I45M,0.33,0.28,0.38
45,M45I,0.39,0.33,0.45
45,I45S,0.54,0.47,0.62
45,S45I,0.58,0.5,0.66
45,I45T,1.14,1.1,1.19
45,T45I,1.2,1.15,1.25
47,H47Q,0.35,0.29,0.4
47,Q47H,0.38,0.32,0.42
54,T54L,0.32,0.3,0.36
54,L54T,0.32,0.29,0.34
54,I54A,0.59,0.52,0.66
54,A54I,0.6,0.53,0.67
56,T56S,0.73,0.67,0.82
56,S56T,0.74,0.66,0.83
56,A56S,0.85,0.79,0.92
56,S56A,0.86,0.8,0.94
62,S62T,0.09,0.02,0.17
62,T62S,0.1,0.02,0.18
62,A62T,0.54,0.48,0.6
62,T62A,0.55,0.49,0.63
63,T63S,0.04,0.01,0.08
63,S63T,0.04,0.01,0.07
63,A63N,0.31,0.22,0.39
63,N63A,0.32,0.23,0.4
64,V64M,0.51,0.45,0.6
64,M64V,0.51,0.44,0.57
65,A65L,0.14,0.01,0.25
65,L65A,0.14,0.02,0.26
65,A65V,0.19,0.08,0.33
65,V65A,0.2,0.08,0.3
65,S65V,0.42,0.34,0.52
65,V65S,0.44,0.36,0.52
67,D67K,0.34,0.3,0.37
67,K67D,0.34,0.3,0.38
67,E67D,0.43,0.34,0.53
67,D67E,0.44,0.34,0.54
67,R67N,0.61,0.54,0.7
67,N67R,0.63,0.54,0.71
77,V77L,0.18,0.13,0.23
77,L77V,0.18,0.14,0.22
79,I79T,0.48,0.27,0.65
79,T79I,0.49,0.33,0.61
83,I83L,0.48,0.39,0.56
83,L83I,0.48,0.41,0.56
83,V83L,0.93,0.86,0.99
83,L83V,0.93,0.87,1.01
88,V88T,0.42,0.37,0.48
88,T88V,0.43,0.36,0.48
89,V89I,0.08,0.04,0.14
89,I89V,0.08,0.02,0.12
89,I89L,0.28,0.25,0.31
89,L89I,0.3,0.27,0.32
95,K95R,0.54,0.44,0.68
95,R95K,0.67,0.53,0.78
104,A104T,0.56,0.52,0.61
104,T104A,0.57,0.53,0.61
104,A104L,0.87,0.85,0.89
104,L104A,0.88,0.85,0.9
111,L111V,0.77,0.65,1.09
111,V111L,0.78,0.66,1.13
113,F113S,0.39,0.32,0.48
113,S113F,0.4,0.32,0.49
113,T113F,0.57,0.48,0.64
113,F113T,0.57,0.51,0.66
113,M113S,0.97,0.93,1.07
113,S113M,0.98,0.92,1.05
113,V113F,1.09,1.01,1.16
113,F113V,1.11,1.04,1.17
113,Q113M,2.15,2.09,2.23
113,M113Q,2.15,2.09,2.24
115,E115A,0.4,0.37,0.44
115,A115E,0.42,0.37,0.45
115,Q115A,0.5,0.47,0.54
115,A115Q,0.52,0.47,0.55
115,T115A,0.72,0.68,0.77
115,A115T,0.74,0.7,0.79
118,N118H,0.03,0.01,0.06
118,H118N,0.04,0,0.07
118,X118H,0.21,0.14,0.33
118,H118X,0.21,0.15,0.28
118,E118R,0.49,0.38,0.59
118,R118E,0.5,0.41,0.61
118,N118R,0.99,0.87,1.12
118,R118N,1.01,0.9,1.1
119,D119T,0.12,0.07,0.16
119,T119D,0.15,0.11,0.2
119,X119S,0.4,0.34,0.46
119,S119X,0.41,0.36,0.47
119,X119T,0.46,0.37,0.55
119,T119X,0.49,0.4,0.57
119,N119S,0.81,0.77,0.85
119,N119T,0.84,0.73,0.93
119,S119N,0.84,0.79,0.88
119,T119N,0.86,0.77,0.98
120,V120L,0.22,0.2,0.24
120,L120V,0.23,0.2,0.24
123,T123F,0.51,0.41,0.6
123,F123T,0.51,0.39,0.61
123,L123T,0.72,0.62,0.82
123,T123L,0.74,0.64,0.86
124,V124T,0.28,0.22,0.35
124,T124V,0.28,0.21,0.35
124,A124V,0.37,0.3,0.43
124,V124A,0.38,0.31,0.44
124,V124G,0.45,0.38,0.51
124,G124V,0.45,0.39,0.5
127,V127I,0.45,0.4,0.49
127,I127V,0.55,0.49,0.6
136,V136I,0.38,0.21,0.61
136,I136V,0.39,0.17,0.59
136,V136L,0.93,0.89,0.97
136,L136V,0.94,0.9,0.98
139,D139Q,0.07,0.02,0.13
139,Q139D,0.09,0.03,0.15
139,N139Q,0.18,0.12,0.24
139,Q139N,0.19,0.13,0.25
139,D139S,0.45,0.39,0.54
139,S139D,0.46,0.39,0.52
139,K139Q,0.54,0.48,0.61
139,Q139S,0.54,0.45,0.68
139,S139Q,0.54,0.44,0.65
139,K139H,0.55,0.52,0.58
139,Q139K,0.56,0.48,0.63
139,H139K,0.56,0.52,0.59
139,H139S,0.64,0.56,0.76
139,S139H,0.66,0.58,0.73
142,K142I,0.08,0.05,0.12
142,I142K,0.09,0.05,0.13
142,I142S,0.09,0.05,0.14
142,S142I,0.09,0.05,0.12
142,K142S,0.27,0.24,0.31
142,S142K,0.29,0.24,0.33
142,S142P,0.35,0.31,0.42
142,P142S,0.35,0.29,0.39
142,L142S,0.42,0.37,0.48
142,S142L,0.44,0.37,0.49
150,L150I,0.47,0.28,0.58
150,I150L,0.51,0.39,0.63
152,L152M,0.2,0.17,0.24
152,M152L,0.23,0.19,0.27
152,I152V,0.36,0.2,0.59
152,V152I,0.37,0.16,0.53
152,I152M,0.65,0.6,0.69
152,M152I,0.68,0.64,0.73
152,V152M,1.04,0.88,1.15
152,M152V,1.06,0.91,1.2
155,I155X,0.4,0.34,0.49
155,X155I,0.42,0.35,0.51
156,R156P,0.47,0.41,0.54
156,P156R,0.47,0.4,0.53
163,C163M,0.04,0.02,0.07
163,C163N,0.37,0.34,0.4
163,N163C,0.37,0.33,0.4
163,C163V,0.4,0.37,0.43
163,V163C,0.4,0.35,0.43
168,I168M,0.24,0.23,0.27
168,M168I,0.24,0.22,0.27
168,A168V,0.71,0.62,0.8
168,V168A,0.73,0.65,0.8
174,I174V,0.03,0.01,0.06
174,V174I,0.06,0.04,0.08
174,M174V,0.16,0.12,0.2
174,M174G,0.18,0.14,0.22
174,V174M,0.23,0.19,0.27
174,G174M,0.25,0.2,0.28
178,L178I,0.18,0.04,0.26
178,F178L,0.21,0.15,0.34
178,L178F,0.36,0.23,0.42
178,F178S,0.37,0.29,0.5
178,S178F,0.51,0.37,0.57
182,M182Q,0.55,0.48,0.61
182,Q182M,0.56,0.48,0.66
191,N191D,0.47,0.41,0.53
191,D191N,0.47,0.41,0.56
191,N191T,0.52,0.46,0.58
191,T191N,0.52,0.45,0.61
202,L202V,0.1,0.06,0.15
202,V202L,0.16,0.1,0.2
202,C202V,0.4,0.33,0.44
202,V202C,0.43,0.38,0.47
209,I209F,0.39,0.32,0.45
209,F209I,0.4,0.33,0.45
210,M210L,0.4,0.28,0.48
210,L210M,0.42,0.33,0.51
210,F210L,0.57,0.43,0.65
210,L210F,0.59,0.47,0.68
210,T210L,1.31,1.18,1.4
210,L210T,1.33,1.24,1.41
214,R214D,0.23,0.19,0.28
214,D214R,0.25,0.2,0.3
214,R214K,0.7,0.67,0.73
214,K214R,0.71,0.69,0.75
215,S215G,0.05,0.01,0.11
215,I215S,0.26,0.22,0.3
215,S215I,0.27,0.22,0.3
215,T215A,0.58,0.48,0.67
215,A215T,0.58,0.5,0.64
216,W216S,0.14,0.02,0.26
216,S216P,0.23,0.18,0.28
216,P216S,0.24,0.18,0.28
216,L216P,0.32,0.27,0.38
216,P216L,0.35,0.27,0.41
216,S216N,0.44,0.38,0.52
216,N216S,0.45,0.37,0.52
216,W216L,1,0.89,1.22
216,L216W,1.02,0.91,1.14
219,X219R,0.46,0.43,0.49
219,R219X,0.46,0.42,0.49