Compound,Smiles,ERK5 IC50 (nM),MLM Clint (mL/min/mg protein),hERG IC50 mM,Caco-2 AB (10-6 cm.s-1),caco-2 ER,HeLa IC50b nM,mouse Cl (ml/min/kg),t1/2 (min),F (%)
32a,O=C(C1=C(Cl)C=CC=C1F)C2=CNC(C(NC3=CN=CN=C3)=O)=C2,400,,,,,,,,
32b,O=C(C1=C(Cl)C=CC=C1F)C2=CNC(C(NC3=CN=C(C)N=C3)=O)=C2,1200,,,,,,,,
32c,O=C(C1=C(Cl)C=CC=C1F)C2=CNC(C(NC3=CN=C(OC)N=C3)=O)=C2,790,,,,,,,,
32d,O=C(C1=C(Cl)C=CC=C1F)C2=CNC(C(NC3=CN=C(N(C)C)N=C3)=O)=C2,3500,,,,,,,,
32e,O=C(C1=C(Cl)C=CC=C1F)C2=CNC(C(NC3=CN=C(N4CCOCC4)N=C3)=O)=C2,2100,,,,,,,,
32f,O=C(C1=C(Cl)C=CC=C1F)C2=CNC(C(NC3=CN=C(N4CCN(CC4)C)N=C3)=O)=C2,72,,,,,,,,
32g,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN=C(N4CCN(CC4)C)N=C3)=O)=C2,37,75,2.63,,,,,,
32i,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN=C(CN4CCNCC4)N=C3)=O)=C2,14,19,,0.3,99,,,,
32k,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN=C(N4CCNCC4)N=C3)=O)=C2,13,13,>25,0.6,35,,,,
32l,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN=C(CN4CCNCC4)N=C3)=O)=C2,8,<5,,0.3,3.7,60,,,
32m,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN=C(CN4CCN(CC4)C)N=C3)=O)=C2,7,28,,0.9,20,20,,,
33f,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CC=C(N4CCNCC4)N=C3)=O)=C2,13,25,>25,0.3,105,,,,
33g,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CC=C(N(C)C4CCN(CC4)C)N=C3)=O)=C2,25,110,,2,14,,,,
33h,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CC=C(CN4CCNCC4)N=C3)=O)=C2,5,7,,0.6,6,,,,
33i,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CC=C(CN4CCN(CC4)C)N=C3)=O)=C2,5,59,,1,30,70,,,
33j,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CC=C(CC4CCN(CC4)C)N=C3)=O)=C2,6,34,,0.7,28,30,20,263,9
33k,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CC=C(OC4CCN(CC4)C)N=C3)=O)=C2,14,50,,2.5,8,60,25,80,13
34a,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CNN=C3)=O)=C2,99,85,,5.6,9.4,,,,
34b,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN(C)N=C3)=O)=C2,79,28,,27,0.9,220,14,80,42
34c,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=NN(C)C=C3)=O)=C2,1038,,,,,,,,
34d,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CC(C)=NO3)=O)=C2,1235,,,,,,,,
34e,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN(C)C=N3)=O)=C2,642,,,,,,,,
34h,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN(C4CCNCC4)N=C3)=O)=C2,19,8.2,,0.3,18,790,,,
34i,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN(C4CCN(CC4)C)N=C3)=O)=C2,22,103,,1.3,15,,,,
34j,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN(CC4CCNCC4)N=C3)=O)=C2,7,0.3,,0.2,4.5,830,,,
34k,O=C(C1=C(Cl)C=CC(Cl)=C1F)C2=CNC(C(NC3=CN(CC4CCN(CC4)C)N=C3)=O)=C2,16,5.9,,0.6,32,,,,