Supplementary Table 2. Coverage of whole-exome sequencing (hg19),,,,,,,,
Cohorts,Patient ID,"Total number of 
sequenced reads 
",Total number of uniquely mapped nonŠ\duplicate reads,"Total number of 
covered bases(Mb)","Average coverage 
(and range) per base",Coverage (>0x),Coverage (>=30x),Coverage (>=100x)
SYSUCC,P137694_F,75022561,55561710,7850.24,119,97.70%,84.81%,47.22%
SYSUCC,P137694_S,70428025,50420443,6877.72,104,97.61%,82.38%,42.07%
SYSUCC,P176723_F,82418505,51869452,8268.59,125,97.42%,83.83%,49.93%
SYSUCC,P176723_S,70410149,47892658,7886.31,119,98.22%,86.04%,50.47%
SYSUCC,P197462_F,67606383,48490708,7680.53,116,96.85%,81.69%,47.46%
SYSUCC,P197462_S,193111380,101609146,8963.91,339,97.80%,93.03%,80.80%
SYSUCC,P237167_C,83362204,62262114,8963.91,136,97.75%,88.35%,56.69%
SYSUCC,P237167_F,162034529,108253368,17588.48,266,98.11%,92.70%,76.99%
SYSUCC,P237167_S,124601113,90530629,13176.3,199,97.83%,90.18%,68.24%
SYSUCC,P238571_C,68082546,52283304,7561.24,114,97.43%,85.64%,48.17%
SYSUCC,P238571_F,189044220,139417483,21004.9,318,97.87%,94.08%,82.74%
SYSUCC,P238571_S,134373549,106113219,15078.83,228,97.75%,92.05%,74.23%
SYSUCC,P243757_C,68324246,51239972,7526.19,114,97.54%,85.46%,47.63%
SYSUCC,P243757_F,79586053,54310744,7384.34,112,97.56%,82.99%,46.47%
SYSUCC,P243757_S,130619584,78777613,14696.66,223,97.54%,90.49%,72.55%
SYSUCC,P243757_T,103168430,65767417,11722.31,177,97.57%,88.89%,65.95%
SYSUCC,P247302_F,73753378,45807426,6536.38,99,96.67%,77.32%,38.44%
SYSUCC,P247302_S,72459868,47465536,8171.45,124,97.01%,83.42%,50.12%
SYSUCC,P258689_C,93929634,68341393,10626.98,161,97.72%,89.35%,63.02%
SYSUCC,P258689_F,117943272,74397060,13398.39,203,97.67%,90.12%,70.02%
SYSUCC,P258689_S,103195900,68042738,11854.84,179,97.52%,88.62%,65.40%
SYSUCC,P270959_C,77370810,58192836,8607.25,130,97.46%,87.22%,54.57%
SYSUCC,P270959_F,64407651,39885528,6026.65,97,96.83%,77.82%,35.86%
SYSUCC,P270959_S,69200639,52683980,7817.24,118,97.25%,83.99%,49.11%
SYSUCC,P277337_C,83235490,62020139,9054.07,137,97.53%,88.28%,56.77%
SYSUCC,P277337_F,60393884,33546840,6897.71,104,96.78%,81.40%,42.09%
SYSUCC,P277337_S,72410323,46616454,8126.42,123,97.18%,83.64%,48.86%
SYSUCC,P286189_C,73043099,55998058,8283.15,125,97.61%,86.25%,52.19%
SYSUCC,P286189_F,136933617,101062529,15542.68,235,97.91%,92.18%,74.67%
SYSUCC,P286189_S,144748866,107919522,16419.83,249,97.92%,92.61%,76.49%
SYSUCC,P286189_T,178665163,129266806,19800.54,300,98.02%,93.72%,80.86%
SYSUCC,P293977_C,86035803,65085512,9840.97,149,97.18%,87.14%,57.17%
SYSUCC,P293977_F,67887101,47232577,7120.53,108,97.12%,80.75%,43.03%
SYSUCC,P293977_S,138423587,93675105,14726.94,223,97.81%,91.81%,73.85%
SYSUCC,P294163_C,109780439,80447653,12387.56,187,97.78%,90.85%,68.93%
SYSUCC,P294163_F,71378648,51647192,7633.01,115,97.62%,84.97%,48.33%
SYSUCC,P294163_S,91793805,66967380,9709.81,147,97.87%,87.68%,58.02%
SYSUCC,P299664_C,70365059,54003717,8013.79,121,97.54%,85.92%,50.80%
SYSUCC,P299664_F,140441952,105861474,15520.3,235,97.95%,92.82%,76.11%
SYSUCC,P299664_S,195480822,138998045,21050.2,319,98.12%,94.52%,83.18%
SYSUCC,P305087_C,119869401,86826791,13654.95,207,97.59%,91.30%,71.74%
SYSUCC,P305087_F,142512482,97310483,15078.48,228,97.86%,91.60%,72.50%
SYSUCC,P305087_S,147562494,97236381,15424.03,234,97.91%,91.82%,73.50%
SYSUCC,P305087_F1,165798594,118719942,18128.31,275,97.73%,92.82%,77.76%
SYSUCC,P305087_S1,150026130,110879291,16605.54,252,97.63%,91.70%,73.88%
SYSUCC,P305087_T,158441610,117092305,17060.52,258,97.88%,93.24%,77.81%
SYSUCC,P310851_C,69616114,52496897,7816,118,97.60%,85.77%,49.62%
SYSUCC,P310851_F,103592646,69411920,10092.3,153,98.02%,89.37%,59.98%
SYSUCC,P310851_S,76227726,55672932,7622.62,115,97.63%,84.51%,45.74%
SYSUCC,P318050_F,90086300,62505770,10131.29,153,97.28%,87.33%,59.44%
SYSUCC,P318050_S,143517113,91674188,16339.45,247,97.51%,91.62%,75.60%
SYSUCC,P342989_C,67893597,51759162,7635.49,115,97.57%,85.48%,48.64%
SYSUCC,P342989_F,215037763,151270978,24015.64,364,98.05%,94.64%,84.33%
SYSUCC,P342989_S,179383456,119706892,19992.72,303,97.99%,93.82%,81.18%
SYSUCC,P364157_C,77420060,60637941,8759.06,132,97.45%,87.09%,55.23%
SYSUCC,P364157_F,89706877,40087671,10197.83,154,96.88%,86.60%,59.64%
SYSUCC,P364157_S,99169083,74373521,11242.68,170,97.49%,88.98%,64.71%
SYSUCC,P376588_C,67676449,50977935,7626.57,115,97.59%,85.47%,48.31%
SYSUCC,P376588_F,93391376,60556761,10594.63,160,97.32%,86.92%,60.05%
SYSUCC,P376588_S,67470004,52529188,7438.64,112,97.42%,83.43%,47.54%
SYSUCC,P379846_C,68662191,53438349,7707.78,116,97.59%,85.62%,49.04%
SYSUCC,P379846_F,116256325,78177078,13031.87,197,97.71%,90.30%,69.62%
SYSUCC,P379846_S,83338063,41287162,9589.32,145,96.88%,84.59%,54.81%
SYSUCC,P388862_C,69385107,52012165,7785.77,118,97.60%,85.74%,49.32%
SYSUCC,P388862_F,116321680,75639860,12980.2,196,97.70%,90.41%,69.88%
SYSUCC,P388862_S,84936969,64550333,9428.66,143,97.69%,87.97%,58.16%
SYSUCC,P395201_C,139018327,100921188,15501.95,235,97.92%,92.67%,75.84%
SYSUCC,P395201_F,121086503,62184187,13995.45,212,97.59%,90.29%,70.00%
SYSUCC,P395201_S,61757126,33212217,7221.12,109,96.77%,80.63%,42.81%
SYSUCC,P398678_C,65713788,49656334,7248.87,110,97.32%,83.40%,43.55%
SYSUCC,P398678_F,158530703,98048326,17123.63,259,98.00%,93.22%,78.03%
SYSUCC,P398678_S,83127183,37771941,9633.1,146,97.14%,86.47%,56.86%
SYSUCC,P404679_C,75518582,58024695,8434.2,128,97.39%,85.45%,50.29%
SYSUCC,P404679_F,194959653,111159466,21645.6,328,97.98%,93.84%,82.17%
SYSUCC,P404679_S,85019134,64657432,9231.13,140,97.74%,87.65%,56.78%
SYSUCC,P411907_C,100289416,71798572,11008.48,167,97.80%,90.31%,65.21%
SYSUCC,P411907_F,120588722,77146726,13114.15,199,97.86%,91.49%,71.11%
SYSUCC,P411907_S,277842305,180650443,29536.28,448,98.28%,95.64%,88.41%
SYSUCC,P432157_C,72673559,55579518,7982.07,121,97.49%,86.69%,51.08%
SYSUCC,P432157_F,98404418,73063642,10481.76,159,97.57%,89.35%,63.43%
SYSUCC,P432157_S,119591482,83975582,13115.39,199,97.63%,90.34%,68.78%
INCB,R001_C,170228413,116091585,14702.54,168,97.40%,94.68%,78.46%
INCB,R002_C,155157920,102741558,13546.72,154.83,97.33%,94.16%,74.46%
INCB,R003_C,169795067,118486872,14729.05,168.35,97.39%,94.84%,79.67%
INCB,R004_C,146973470,116553191,12780.32,146.07,97.34%,94.96%,81.15%
INCB,R005_C,151295574,96164341,13132,150.1,97.20%,93.80%,72.33%
INCB,R006_C,163766987,145994070,14414.5,164.75,97.33%,96.09%,91.63%
INCB,R007_C,146598767,79905547,12491.92,142.78,96.52%,77.17%,47.37%
INCB,R008_C,186110885,171118350,14778.34,168.91,97.52%,95.41%,85.49%
INCB,R009_C,78682691,75630681,3016.39,34.48,97.38%,79.44%,30.56%
INCB,R010_C,194860122,166685918,17393.56,198.8,97.36%,96.28%,93.30%
INCB,R011_C,85444936,82378245,3271.71,37.39,97.70%,82.97%,38.21%
INCB,R012_C,165095546,114207686,14357.5,164.1,97.36%,94.75%,78.68%
INCB,R013_C,159681405,143900246,13777.93,157.47,97.38%,96.09%,91.89%
INCB,R014_C,75785013,72961433,3171.11,36.24,97.60%,82.55%,35.54%
INCB,R015_C,137794059,126171533,12003,137.19,97.38%,96.01%,90.07%
INCB,R016_C,227003807,198420509,20178.33,230.63,97.50%,96.38%,93.06%
INCB,R017_C,170852748,131373913,9562.92,109.3,97.51%,91.84%,81.97%
INCB,R018_C,154302533,120326927,9239.7,105.61,96.89%,91.71%,81.41%
INCB,R019_C,158582741,120217111,9540.93,109.05,96.87%,91.55%,81.16%
INCB,R001_F,198504694,132123466,16817.2,192.21,97.47%,95.10%,80.92%
INCB,R002_F,178682492,73043699,14990.25,171,97.22%,89.99%,53.69%
INCB,R003_F,201792737,151997512,17178.31,196,97.46%,95.44%,84.94%
INCB,R004_F,187124199,116903416,16059.94,183.56,97.26%,94.58%,78.20%
INCB,R005_F,188183155,129403804,16073.2,183.71,97.35%,94.96%,81.03%
INCB,R006_F,149165355,123427266,13207,150,97.25%,95.87%,89.22%
INCB,R007_F,152615650,52239890,12247.36,139.98,96.99%,77.38%,30.87%
INCB,R008_F,137833452,80630178,11752.52,134.33,97.10%,91.25%,59.36%
INCB,R009_F,84604294,80804498,3242,37.05,97.39%,79.32%,32.72%
INCB,R010_F,159184087,58352681,14074,160.86,97.12%,85.83%,41.15%
INCB,R011_F,78405016,74355027,3411.27,38.99,97.69%,85.21%,35.89%
INCB,R012_F,183408792,105176039,15690.38,179.33,97.39%,94.15%,73.94%
INCB,R013_F,137685147,123614413,11966.07,136.77,97.26%,95.87%,89.55%
INCB,R014_F,79877827,77534059,2954.89,33.77,97.69%,81.61%,31.83%
INCB,R015_F,132471570,131340336,11543.6,131.94,97.35%,95.88%,88.33%
INCB,R016_F,147798353,135353290,12874.61,147.15,97.38%,96.14%,91.21%
INCB,R017_F,161651179,128081998,8975.12,102.58,97.36%,91.03%,79.82%
INCB,R018_F,157000228,118898612,9375.67,107.16,96.98%,91.78%,81.28%
INCB,R019_F,164185148,128342515,9674.53,110.58,97.02%,91.69%,81.49%
INCB,R001_S,154875317,117486099,13054.19,149.2,97.43%,94.61%,77.87%
INCB,R002_S,168048030,80923956,14651.11,167.45,97.24%,90.96%,57.22%
INCB,R003_S,158901232,69411691,13955.09,159.5,97.20%,90.92%,56.44%
INCB,R004_S,170685545,98972343,14271.43,163.12,97.25%,93.00%,66.47%
INCB,R005_S,170154259,126422492,14603.38,166.91,97.27%,94.92%,80.39%
INCB,R006_S,136721192,119108536,12000.92,137.16,97.27%,95.80%,87.65%
INCB,R007_S,146289578,75593458,11779.1,134.63,97.14%,88.33%,50.49%
INCB,R008_S,123419365,87520481,10607.51,121.24,97.19%,92.63%,65.28%
INCB,R009_S,64570195,62067976,3529.11,40.34,96.83%,80.57%,37.60%
INCB,R010_S,186865640,88605666,16569.09,189.38,97.23%,92.67%,65.96%
INCB,R011_S,81769905,79346716,3222.64,36.83,97.65%,82.68%,37.25%
INCB,R012_S,185615151,124893158,16033.33,183.25,97.40%,94.65%,78.88%
INCB,R013_S,160865347,147233315,14149.64,161.72,97.28%,96.09%,92.13%
INCB,R014_S,71333510,68718975,3195,36.52,97.37%,82.02%,36.39%
INCB,R015_S,122120479,106894726,10715.6,122.47,97.35%,95.94%,88.08%
INCB,R016_S,142094825,130556534,12315,140.76,97.41%,96.14%,90.66%
INCB,R017_S,114817044,100843741,4643.34,53.07,98.76%,64.23%,30.30%
INCB,R018_S,82135809,76631859,3674.83,42,98.86%,91.39%,40.19%
INCB,R019_S,77592343,73094637,3533.44,40.39,98.81%,94.65%,42.05%
,,,,,,,,