pcFos_cJun cMyc p53ac FOXOnuc ppERKnuc pRSKnuc bCATENINnuc TP53 0 0 0 0 0 0 0 MDM2 0 0 0 0 0 0 0 PPM1D 0 0 0 0 0 0 0 ATM 0 0 0 0 0 0 0 ATR 0 0 0 0 0 0 0 RB1 0 0 0 0 0 0 0 E2F1 0 0 0 0 0 0 0 E2F2 0 0 0 0 0 0 0 E2F3 0 0 0 0 0 0 0 CCND1 3.0; 1.25 3.0; 450.0 0 0 0 0 0 CCND2 3.0; 1.25 3.0; 450.0 0 0 0 0 0 CCND3 3.0; 1.25 3.0; 450.0 0 0 0 0 0 CCNE1 0 0 0 0 0 0 0 CCNE2 0 0 0 0 0 0 0 SKP2 0 0 0 0 0 0 0 CDC25A 0 0 0 0 0 0 0 CDC25B 0 0 0 0 0 0 0 CDC25C 0 0 0 0 0 0 0 CCNA2 0 0 0 0 0 0 0 CDKN1B 0 0 0 0 0 0 0 CDH1 0 0 0 0 0 0 0 CCNB1 0 0 0 0 0 0 0 CDC20 0 0 0 0 0 0 0 WEE1 0 0 0 0 0 0 0 CHEK1 0 0 0 0 0 0 0 CDKN1A 0 0 4.0; 50.0 0 0 0 0 CDK1 0 0 0 0 0 0 0 CDK2 0 0 0 0 0 0 0 CDK4 0 0 0 0 0 0 0 CDK6 0 0 0 0 0 0 0 TNFSF10 0 0 0 0 0 0 0 TNFRSF10A 0 0 0 0 0 0 0 TNFRSF10B 0 0 0 0 0 0 0 CFLAR 0 0 0 0 0 0 0 CASP8 0 0 0 0 0 0 0 CASP10 0 0 0 0 0 0 0 BFAR 0 0 0 0 0 0 0 CASP3 0 0 0 0 0 0 0 CASP7 0 0 0 0 0 0 0 CASP6 0 0 0 0 0 0 0 XIAP 0 0 0 0 0 0 0 PARP1 0 0 0 0 0 0 0 BID 0 0 0 0 0 0 0 BCL2 0 0 0 0 0 0 0 BCL2L1 0 0 0 0 0 0 0 MCL1 0 0 0 0 0 0 0 BAX 0 0 0 0 0 0 0 CYCS 0 0 0 0 0 0 0 DIABLO 0 0 0 0 0 0 0 APAF1 0 0 0 0 0 0 0 CASP9 0 0 0 0 0 0 0 BAD 0 0 0 0 0 0 0 BBC3 0 0 4.0; 1350.0 0 0 0 0 PMAIP1 0 0 4.0; 1350.0 0 0 0 0 BCL2L11 0 0 0 4.0; 45.0 0 0 0 EGF 0 0 0 0 0 0 0 NRG1 0 0 0 0 0 0 0 EGFR 0 0 0 4.0; 60.0 0 0 0 ERBB2 0 0 0 4.0; 60.0 0 0 0 ERBB3 0 0 0 4.0; 60.0 0 0 0 ERBB4 0 0 0 4.0; 60.0 0 0 0 EGFRvIII 0 0 0 0 0 0 0 MET 0 0 0 4.0; 60.0 0 0 0 HGF 0 0 0 0 0 0 0 PDGFRA 0 0 0 4.0; 60.0 0 0 0 PDGFRB 0 0 0 4.0; 60.0 0 0 0 PDGFB 0 0 0 0 0 0 0 SPRY2 0 0 0 0 4.0; 65.0 4.0; 20.0 0 CBL 0 0 0 0 0 0 0 GRB2 0 0 0 0 0 0 0 PLCG1 0 0 0 0 0 0 0 PLCG2 0 0 0 0 0 0 0 PIK3CA 0 0 0 0 0 0 0 PIK3CB 0 0 0 0 0 0 0 PIK3CG 0 0 0 0 0 0 0 PIK3CD 0 0 0 0 0 0 0 PIK3R1 0 0 0 0 0 0 0 PIK3R2 0 0 0 0 0 0 0 PIK3R3 0 0 0 0 0 0 0 PIK3R4 0 0 0 0 0 0 0 PIK3C2A 0 0 0 0 0 0 0 RASGRP1 0 0 0 0 0 0 0 RASGRP3 0 0 0 0 0 0 0 NRAS 0 0 0 0 0 0 0 KRAS 0 0 0 0 0 0 0 HRAS 0 0 0 0 0 0 0 NF1 0 0 0 0 0 0 0 RAF1 0 0 0 0 0 0 0 BRAF 0 0 0 0 0 0 0 MAP2K1 0 0 0 0 0 0 0 MAP2K2 0 0 0 0 0 0 0 DUSP6 0 0 0 0 4.0; 40.0 4.0; 10.0 0 RPS6KA1 0 0 0 0 0 0 0 RPS6KA2 0 0 0 0 0 0 0 RPS6KA3 0 0 0 0 0 0 0 RPS6KA4 0 0 0 0 0 0 0 DUSP1 0 0 0 0 4.0; 40.0 4.0; 10.0 0 FOS -4.0; 0.8 0 0 0 4.0; 20.0 4.0; 5.0 0 JUN 3.0; 0.8 0 0 0 0 0 0 MYC 0 0 0 0 0 0 4.0; 250 CTNNB1 0 0 0 0 0 0 0 PTEN 0 0 0 0 0 0 0 AKT1 0 0 0 0 0 0 0 AKT2 0 0 0 0 0 0 0 PDPK1 0 0 0 0 0 0 0 RICTOR 0 0 0 0 0 0 0 MTOR 0 0 0 0 0 0 0 GSK3B 0 0 0 0 0 0 0 TSC1 0 0 0 0 0 0 0 TSC2 0 0 0 0 0 0 0 PRKCA 0 0 0 0 0 0 0 PRKCB 0 0 0 0 0 0 0 PRKCG 0 0 0 0 0 0 0 PRKCD 0 0 0 0 0 0 0 PEBP1 0 0 0 0 0 0 0 MAPK1 0 0 0 0 0 0 0 MAPK3 0 0 0 0 0 0 0 FOXO3 0 0 0 0 0 0 0 RHEB 0 0 0 0 0 0 0 RPTOR 0 0 0 0 0 0 0 RPS6KB1 0 0 0 0 0 0 0 RPS6KB2 0 0 0 0 0 0 0 EIF4EBP1 0 0 0 0 0 0 0 SOS1 0 0 0 0 0 0 0 CDKN2A 0 0 0 0 0 0 0 MDM4 0 0 0 0 0 0 0 FGFR1 0 0 0 4.0; 60.0 0 0 0 FGFR2 0 0 0 4.0; 60.0 0 0 0 FGF1 0 0 0 0 0 0 0 FGF2 0 0 0 0 0 0 0 EIF4E 0 0 0 0 0 0 0 IRS1 0 0 0 0 0 0 0 IRS2 0 0 0 0 0 0 0 IGF1 0 0 0 0 0 0 0 IGF2 0 0 0 0 0 0 0 IGF1R 0 0 0 4.0; 60.0 0 0 0 MSH6 0 0 0 0 0 0 0 BRCA2 0 0 0 0 0 0 0 MGMT 0 0 0 0 0 0 0 INSR 0 0 0 4.0; 60.0 0 0 0 INS 0 0 0 0 0 0 0