Term Overlap P-value Adjusted P-value Old P-value Old Adjusted P-value Odds Ratio Combined Score Genes etoposide MCF7 DOWN 4/48 4.36E-10 7.98E-08 0 0 906.8181818 19544.3738 CDC20;UBE2C;KIF2C;KIF20A methotrexate MCF7 DOWN 4/52 6.07E-10 7.98E-08 0 0 831.0833333 17637.87104 CDC20;UBE2C;KIF2C;KIF20A LUCANTHONE CTD 00006227 5/213 7.78E-10 7.98E-08 0 0 475.625 9976.194707 CDC20;CDK1;PBK;KIF2C;KIF20A troglitazone CTD 00002415 6/651 1.16E-09 8.95E-08 0 0 116094 2388335.205 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A ciclopirox MCF7 DOWN 4/67 1.72E-09 9.36E-08 0 0 632.7301587 12770.53449 CDC20;UBE2C;KIF2C;KIF20A 5109870 MCF7 DOWN 4/68 1.82E-09 9.36E-08 0 0 622.8125 12532.65563 CDC20;UBE2C;KIF2C;KIF20A thalidomide CTD 00006858 4/141 3.51E-08 1.55E-06 0 0 289.8832117 4975.730017 CDC20;UBE2C;CDK1;KIF2C genistein CTD 00007324 6/1231 5.37E-08 1.79E-06 0 0 112614 1885047.942 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A dmnq CTD 00002569 4/157 5.41E-08 1.79E-06 0 0 259.3594771 4339.48167 CDC20;UBE2C;PBK;KIF2C testosterone CTD 00006844 6/1247 5.81E-08 1.79E-06 0 0 112518 1874704.99 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A bicalutamide CTD 00002279 4/170 7.46E-08 2.09E-06 0 0 238.8915663 3920.544872 CDC20;CDK1;PBK;KIF20A trifluridine MCF7 DOWN 3/33 8.16E-08 2.09E-06 0 0 665.4666667 10861.6499 CDC20;UBE2C;KIF20A monobenzone PC3 DOWN 4/204 1.55E-07 3.68E-06 0 0 197.94 3103.478354 CDC20;UBE2C;KIF2C;KIF20A 0173570-0000 PC3 DOWN 3/43 1.84E-07 4.05E-06 0 0 498.85 7735.545838 CDC20;KIF2C;KIF20A Phytoestrogens CTD 00007437 3/48 2.58E-07 5.30E-06 0 0 443.3111111 6724.926477 CDK1;PBK;KIF2C caffeic acid CTD 00001850 3/62 5.64E-07 1.08E-05 0 0 337.8813559 4861.765262 CDC20;UBE2C;KIF2C calcitriol CTD 00005558 6/1958 8.74E-07 1.58E-05 0 0 108252 1510100.587 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A 5-azacytidine CTD 00005455 4/352 1.38E-06 2.27E-05 0 0 112.908046 1523.840692 CDC20;UBE2C;CDK1;KIF2C 67526-95-8 CTD 00007263 5/953 1.40E-06 2.27E-05 0 0 100.4535865 1353.914682 CDC20;UBE2C;CDK1;KIF2C;KIF20A resveratrol MCF7 DOWN 3/104 2.70E-06 4.16E-05 0 0 196.960396 2525.416306 CDC20;UBE2C;KIF20A Phorbol 12-myristate 13-acetate CTD 00006852 4/483 4.85E-06 7.11E-05 0 0 81.4822547 997.0773754 CDC20;PBK;KIF2C;KIF20A Bisphenol A CTD 00000312 5/1262 5.65E-06 7.57E-05 0 0 74.53062848 900.6823055 CDC20;UBE2C;CDK1;PBK;KIF20A Dasatinib CTD 00004330 4/502 5.65E-06 7.57E-05 0 0 78.29718876 946.1028175 CDC20;CDK1;PBK;KIF2C glibenclamide HL60 DOWN 5/1333 7.40E-06 9.50E-05 0 0 70.27861446 830.2544847 CDC20;UBE2C;CDK1;PBK;KIF2C piroxicam CTD 00006571 4/549 8.06E-06 9.93E-05 0 0 71.37247706 837.0775566 CDK1;PBK;KIF2C;KIF20A 7646-79-9 CTD 00000928 6/3094 1.37E-05 1.62E-04 0 0 101436 1136262.322 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A deferoxamine MCF7 DOWN 2月20日 1.42E-05 1.62E-04 0 0 554.8888889 6193.205891 CDC20;KIF20A monobenzone MCF7 DOWN 2月21日 1.57E-05 1.73E-04 0 0 525.6578947 5814.413882 CDC20;KIF20A NICKEL CTD 00006389 3/189 1.63E-05 1.73E-04 0 0 106.4946237 1174.24526 CDC20;PBK;KIF2C clindamycin HL60 DOWN 5/1626 1.98E-05 2.03E-04 0 0 56.67180753 613.8660907 CDC20;UBE2C;CDK1;PBK;KIF2C COPPER CTD 00005706 5/1688 2.38E-05 2.36E-04 0 0 54.39988116 579.2166566 UBE2C;CDK1;PBK;KIF2C;KIF20A Methyl 4-methoxycinnamate CTD 00002989 2/33 3.94E-05 3.80E-04 0 0 321.983871 3265.179181 CDC20;KIF2C TETRACHLOROETHYLENE CTD 00006849 2/41 6.12E-05 5.71E-04 0 0 255.8333333 2482.010933 PBK;KIF2C Fulvestrant CTD 00002740 3/310 7.12E-05 6.45E-04 0 0 64.12703583 612.3701319 CDC20;CDK1;KIF20A Enterolactone CTD 00001393 4/971 7.66E-05 6.74E-04 0 0 39.35263702 372.9595324 CDK1;PBK;KIF2C;KIF20A etoposide HL60 DOWN 2/49 8.76E-05 7.50E-04 0 0 212.2021277 1982.427537 CDC20;UBE2C PNU-0293363 MCF7 DOWN 2/50 9.13E-05 7.60E-04 0 0 207.7708333 1932.575689 CDC20;KIF20A estradiol CTD 00005920 6/4336 1.04E-04 8.39E-04 0 0 93984 862343.7076 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A hyoscyamine CTD 00005451 2/54 1.07E-04 8.42E-04 0 0 191.75 1753.85619 CDC20;CDK1 benzo[a]pyrene CTD 00005488 6/4424 1.17E-04 9.00E-04 0 0 93456 846226.2379 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A ciclopirox HL60 DOWN 2/61 1.36E-04 0.001022976 0 0 168.940678 1503.836809 CDC20;KIF20A CUPRIC OXIDE CTD 00001471 3/393 1.44E-04 0.001056734 0 0 50.26666667 444.6088068 CDC20;CDK1;KIF20A 5-Fluorouracil CTD 00005987 4/1202 1.77E-04 0.001264733 0 0 31.37896494 271.1705468 CDC20;UBE2C;CDK1;KIF2C cyclosporin A CTD 00007121 6/4825 1.97E-04 0.001376772 0 0 91050 777013.7694 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A irinotecan MCF7 DOWN 4/1272 2.20E-04 0.001507137 0 0 29.5362776 248.7244282 CDC20;CDK1;KIF2C;KIF20A chlorzoxazone HL60 DOWN 4/1286 2.30E-04 0.001514138 0 0 29.19188768 244.5790379 CDC20;CDK1;PBK;KIF2C etoposide CTD 00005948 3/461 2.31E-04 0.001514138 0 0 42.65502183 357.1445812 UBE2C;PBK;KIF20A SB 202190 CTD 00003161 2/91 3.04E-04 0.001947482 0 0 111.8258427 905.8023969 CDC20;CDK1 hydroxyurea CTD 00006132 2/96 3.38E-04 0.00212295 0 0 105.8510638 846.0917099 UBE2C;KIF20A curcumin CTD 00000663 3/528 3.45E-04 0.002123862 0 0 37.08380952 295.6542246 CDC20;UBE2C;CDK1 Irinotecan hydrochloride CTD 00002224 3/565 4.21E-04 0.002541511 0 0 34.57651246 268.7725891 CDC20;UBE2C;CDK1 AFLATOXIN B1 CTD 00007128 5/3081 4.53E-04 0.002680518 0 0 27.5 211.766534 CDC20;CDK1;PBK;KIF2C;KIF20A azacitidine PC3 DOWN 3/595 4.90E-04 0.002847181 0 0 32.77364865 249.7756427 UBE2C;CDK1;KIF2C resveratrol CTD 00002483 4/1601 5.38E-04 0.003068436 0 0 23.03944897 173.4341304 CDK1;PBK;KIF2C;KIF20A ZINC CTD 00007011 4/1642 5.93E-04 0.003321985 0 0 22.41269841 166.5254361 CDC20;UBE2C;KIF2C;KIF20A 0175029-0000 PC3 DOWN 5/3326 6.56E-04 0.003607242 0 0 25.1023788 183.989392 CDC20;UBE2C;CDK1;KIF2C;KIF20A Copper sulfate CTD 00007279 6/6016 7.39E-04 0.003995532 0 0 83904 604916.5396 CDC20;UBE2C;CDK1;PBK;KIF2C;KIF20A CHROMIUM CTD 00005668 2/148 8.00E-04 0.004248891 0 0 67.97260274 484.6959126 UBE2C;CDK1 puromycin PC3 DOWN 3/722 8.63E-04 0.004452208 0 0 26.80806676 189.1188333 CDK1;KIF2C;KIF20A COUMESTROL CTD 00005717 4/1812 8.67E-04 0.004452208 0 0 20.11725664 141.8288805 CDK1;PBK;KIF2C;KIF20A medrysone HL60 DOWN 3/760 0.001002919 0.005063918 0 0 25.41215324 175.4668702 CDK1;PBK;KIF20A progesterone CTD 00006624 4/1915 0.001072613 0.005328467 0 0 18.92517007 129.4038237 CDC20;CDK1;PBK;KIF20A Tetradioxin CTD 00006848 5/3768 0.001198187 0.005857804 0 0 21.56656923 145.0771373 CDC20;UBE2C;CDK1;PBK;KIF20A 8-azaguanine PC3 DOWN 2/207 0.001555907 0.007487805 0 0 48.26585366 312.0723537 KIF2C;KIF20A vinblastine CTD 00006986 2/227 0.001866885 0.00878805 0 0 43.93111111 276.0404432 CDK1;KIF20A FENRETINIDE CTD 00007166 2/228 0.001883153 0.00878805 0 0 43.73451327 274.4256525 UBE2C;CDK1 rapamycin CTD 00007350 2/247 0.002205219 0.010137424 0 0 40.30408163 246.537186 CDC20;CDK1 chlortetracycline HL60 DOWN 3/1050 0.002560195 0.011596176 0 0 18.09646609 107.9937733 CDC20;CDK1;KIF2C MS-275 PC3 DOWN 2/294 0.003106692 0.013867554 0 0 33.73630137 194.8000408 KIF2C;KIF20A trichostatin A PC3 DOWN 3/1133 0.003186272 0.014019598 0 0 16.69380531 95.97107773 UBE2C;KIF2C;KIF20A CADMIUM CTD 00005555 3/1142 0.003259448 0.01409881 0 0 16.55399473 94.79144049 CDK1;PBK;KIF2C CHEMBL380598 TTD 00005159 1月11日 0.003295826 0.01409881 0 0 399.68 2284.210592 CDK1 mitomycin C CTD 00007136 2/308 0.003403743 0.014360997 0 0 32.16993464 182.8178664 PBK;KIF20A hydrogen peroxide CTD 00006118 4/2673 0.003813178 0.014992271 0 0 12.98239041 72.30272773 CDC20;UBE2C;CDK1;KIF20A fenofibrate TTD 00008002 1月13日 0.003894096 0.014992271 0 0 333.0333333 1847.76671 CDK1 roscovitine TTD 00010683 1月13日 0.003894096 0.014992271 0 0 333.0333333 1847.76671 CDK1 "1H-Pyrrole-2,5-dione, 3,4-diphenyl- TTD 00000418" 1月13日 0.003894096 0.014992271 0 0 333.0333333 1847.76671 CDK1 amifostine CTD 00005933 1月13日 0.003894096 0.014992271 0 0 333.0333333 1847.76671 CDK1 "1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)- TTD 00000417" 1月13日 0.003894096 0.014992271 0 0 333.0333333 1847.76671 CDK1 AGN-PC-00BUNE TTD 00001660 1月13日 0.003894096 0.014992271 0 0 333.0333333 1847.76671 CDK1 danazol HL60 DOWN 3/1233 0.004059724 0.015436974 0 0 15.25528455 84.00536552 CDC20;CDK1;KIF2C cinnarizine TTD 00007193 1月14日 0.00419312 0.015560011 0 0 307.4 1682.802968 CDK1 cinnarizine CTD 00005673 1月14日 0.00419312 0.015560011 0 0 307.4 1682.802968 CDK1 atovaquone MCF7 DOWN 2/354 0.004470581 0.016392129 0 0 27.90056818 150.9486858 CDK1;PBK Arsenenous acid CTD 00000922 3/1283 0.004547602 0.01647837 0 0 14.6203125 78.84961454 CDC20;UBE2C;CDK1 N-Methyl-N-nitrosourea CTD 00006319 1月16日 0.004790942 0.016961037 0 0 266.3866667 1422.778691 CDK1 bay 11-7082 TTD 00002312 1月16日 0.004790942 0.016961037 0 0 266.3866667 1422.778691 CDK1 alsterpaullone TTD 00001927 1月17日 0.005089741 0.017613937 0 0 249.725 1318.679916 CDK1 Calpain inhibitor I CTD 00002578 1月17日 0.005089741 0.017613937 0 0 249.725 1318.679916 CDC20 mechlorethamine CTD 00006251 1月18日 0.005388466 0.018440528 0 0 235.0235294 1227.644124 CDK1 purvalanol A TTD 00010395 1月19日 0.005687116 0.018976804 0 0 221.9555556 1147.410799 CDK1 Methaneseleninic acid CTD 00000412 2/402 0.005730009 0.018976804 0 0 24.4925 126.4312195 CDC20;CDK1 Dronabinol CTD 00006853 2/402 0.005730009 0.018976804 0 0 24.4925 126.4312195 UBE2C;CDK1 MG-262 MCF7 DOWN 2/407 0.005869666 0.019232523 0 0 24.18395062 124.2561116 CDK1;KIF2C Flavopiridol hydrochloride TTD 00008047 1月20日 0.005985691 0.01940624 0 0 210.2631579 1076.207481 CDK1 POTASSIUM BROMATE CTD 00000989 1月21日 0.006284191 0.020161781 0 0 199.74 1012.625496 CDK1 Zoledronic acid CTD 00003127 2/425 0.006385523 0.020275682 0 0 23.13356974 116.910627 CDC20;KIF20A GW779439X GSK 1月22日 0.006582617 0.020688225 0 0 190.2190476 955.5316922 CDK1 deptropine HL60 DOWN 2/435 0.006680923 0.020785095 0 0 22.58775982 113.1307742 CDK1;KIF2C Flavopiridol hydrochloride BOSS 1月23日 0.006880968 0.020983547 0 0 181.5636364 904.0045996 CDK1 citrinin CTD 00005677 1月23日 0.006880968 0.020983547 0 0 181.5636364 904.0045996 CDK1 quercetin CTD 00006679 4/3158 0.007114303 0.021384108 0 0 10.67850349 52.81212015 CDC20;CDK1;PBK;KIF20A "2H-1-Benzopyran-2-one, 7-[(3,7-dimethyl-2,6-octadienyl)oxy]- CTD 00003446" 1月24日 0.007179245 0.021384108 0 0 173.6608696 857.2874885 CDK1 lobeline HL60 DOWN 3/1510 0.007220608 0.021384108 0 0 12.26741871 60.48838621 CDC20;CDK1;KIF2C Bis-gma CTD 00007186 1月26日 0.007775574 0.022808351 0 0 159.752 775.8783981 CDK1 bisindolylmaleimide i TTD 00002466 1月27日 0.008073627 0.023422883 0 0 153.6 740.2218192 CDK1 azacitidine MCF7 DOWN 2/482 0.008152715 0.023422883 0 0 20.32708333 97.76116205 CDK1;KIF2C cicloheximide HL60 UP 2/485 0.008251289 0.023422883 0 0 20.19772257 96.89626925 KIF2C;KIF20A Vinblastine sulfate BOSS 1月28日 0.008371605 0.023422883 0 0 147.9037037 707.4100516 CDK1 roscovitine CTD 00003426 1月28日 0.008371605 0.023422883 0 0 147.9037037 707.4100516 CDK1 paclitaxel CTD 00007144 2/493 0.008516845 0.023422883 0 0 19.8604888 94.64931525 CDC20;CDK1 kenpaullone TTD 00008780 1月29日 0.008669509 0.023422883 0 0 142.6142857 677.1245224 CDK1 CGP 60474 TTD 00002787 1月29日 0.008669509 0.023422883 0 0 142.6142857 677.1245224 CDK1 bisindolylmaleimide iv TTD 00002467 1月29日 0.008669509 0.023422883 0 0 142.6142857 677.1245224 CDK1 7-Hydroxystaurosporine CTD 00002331 1月30日 0.008967338 0.02401687 0 0 137.6896552 649.0919521 CDK1 patulin CTD 00006474 1月31日 0.009265092 0.024600417 0 0 133.0933333 623.0766346 CDK1 2-Methylcholine CTD 00002006 3/1666 0.00952176 0.02506583 0 0 11.02285027 51.30228033 UBE2C;CDK1;PBK sertraline 1/33 0.009860378 0.025737257 0 0 124.7625 576.3067827 CDK1 amsacrine CTD 00005396 1/35 0.010455365 0.026613657 0 0 117.4117647 535.4727919 UBE2C leucovorin CTD 00005678 1/35 0.010455365 0.026613657 0 0 117.4117647 535.4727919 CDK1 Go 6976 CTD 00002962 1/35 0.010455365 0.026613657 0 0 117.4117647 535.4727919 CDK1 dirithromycin HL60 DOWN 2/556 0.010743526 0.027123 0 0 17.54512635 79.53998729 CDC20;KIF2C malathion CTD 00006233 1/37 0.011050055 0.027670056 0 0 110.8777778 499.5398568 CDC20 tubocurarine CTD 00006958 1/39 0.011644447 0.028464203 0 0 105.0315789 467.6978365 UBE2C chlorambucil CTD 00005626 1/39 0.011644447 0.028464203 0 0 105.0315789 467.6978365 CDK1 pentoxifylline CTD 00006487 1/39 0.011644447 0.028464203 0 0 105.0315789 467.6978365 CDK1 4-Hydroxytamoxifen CTD 00000850 2/586 0.01188707 0.028734309 0 0 16.61815068 73.65669634 CDK1;KIF20A "Pregna-4,17(20)-diene-3,16-dione CTD 00001094" 1/40 0.011941531 0.028734309 0 0 102.3333333 453.1046715 CDK1 CHEMBL35349 CTD 00001274 1/41 0.012238541 0.028995928 0 0 99.77 439.3037926 CDK1 mephentermine HL60 DOWN 1/41 0.012238541 0.028995928 0 0 99.77 439.3037926 CDC20 DIALLYL DISULFIDE CTD 00001321 1/42 0.012535477 0.029472724 0 0 97.33170732 426.2342855 CDK1 benzene CTD 00005481 2/615 0.013042614 0.030183634 0 0 15.80831974 68.60072914 CDK1;KIF20A okadaic acid BOSS 1/45 0.013425837 0.030183634 0 0 90.68181818 390.8907142 CDK1 PKR Inhibitor RBC 1/45 0.013425837 0.030183634 0 0 90.68181818 390.8907142 CDK1 dorsomorphin CTD 00004649 1/45 0.013425837 0.030183634 0 0 90.68181818 390.8907142 CDK1 clotrimazole TTD 00007242 1/45 0.013425837 0.030183634 0 0 90.68181818 390.8907142 CDK1 2-CHLOROETHYL ETHYL SULFIDE CTD 00001489 1/45 0.013425837 0.030183634 0 0 90.68181818 390.8907142 CDK1 Cardidigin CTD 00005822 1/47 0.014019039 0.03128887 0 0 86.73043478 370.1081619 CDK1 gossypol HL60 DOWN 1/48 0.014315529 0.031494163 0 0 84.88085106 360.4389302 KIF20A nocodazole BOSS 1/48 0.014315529 0.031494163 0 0 84.88085106 360.4389302 CDK1 Leptomycin B CTD 00001805 1/50 0.014908285 0.032296565 0 0 81.40816327 342.3895623 CDK1 506-26-3 CTD 00007216 1/50 0.014908285 0.032296565 0 0 81.40816327 342.3895623 CDK1 Chalcone BOSS 1/51 0.015204552 0.032296565 0 0 79.776 333.9551363 CDK1 clofibrate CTD 00005684 1/51 0.015204552 0.032296565 0 0 79.776 333.9551363 CDK1 choline CTD 00005662 1/51 0.015204552 0.032296565 0 0 79.776 333.9551363 KIF20A clotrimazole BOSS 1/53 0.015796862 0.033324888 0 0 76.7 318.1473008 CDK1 cadmium acetate CTD 00001325 1/54 0.016092906 0.033428966 0 0 75.2490566 310.7317013 CDK1 Picrotoxinum BOSS 1/54 0.016092906 0.033428966 0 0 75.2490566 310.7317013 CDK1 scriptaid PC3 DOWN 2/692 0.016345047 0.033428966 0 0 13.9884058 57.54592813 KIF2C;KIF20A Tanespimycin CTD 00003582 1/55 0.016388876 0.033428966 0 0 73.85185185 303.6162219 CDK1 JAK3 Inhibitor VI RBC 1/55 0.016388876 0.033428966 0 0 73.85185185 303.6162219 CDK1 azacyclonol HL60 DOWN 2/703 0.016844119 0.034131505 0 0 13.76105563 56.19676155 CDK1;KIF2C hydroxyurea BOSS 1/58 0.017276341 0.034552682 0 0 69.95438596 283.9040901 CDK1 Alvocidib CTD 00002892 1/58 0.017276341 0.034552682 0 0 69.95438596 283.9040901 CDK1 Caffeic acid phenethyl ester CTD 00002352 1/59 0.017572014 0.034693464 0 0 68.74482759 277.8286292 CDK1 Nitroprusside CTD 00006411 1/59 0.017572014 0.034693464 0 0 68.74482759 277.8286292 CDK1 "1h-pyrazolo[3,4-d]pyrimidine CTD 00000742" 1/61 0.018163138 0.035632143 0 0 66.44666667 266.3422351 CDK1 Belinostat CTD 00004313 1/64 0.019049269 0.036550091 0 0 63.27301587 250.6071154 CDK1 arecoline CTD 00005439 1/64 0.019049269 0.036550091 0 0 63.27301587 250.6071154 CDK1 doxorubicin CTD 00005874 2/750 0.019051818 0.036550091 0 0 12.86497326 50.95291965 CDK1;KIF20A acetaminophen CTD 00005295 4/4135 0.019105729 0.036550091 0 0 7.679980634 30.39557403 UBE2C;CDK1;KIF2C;KIF20A Mangiferin CTD 00000713 1/65 0.019344497 0.036778427 0 0 62.28125 245.7211603 CDK1 Melatonin CTD 00006260 1/66 0.019639652 0.037110508 0 0 61.32 241.0001522 CDK1 parathion CTD 00006472 2/776 0.020324854 0.038171067 0 0 12.41602067 48.37170907 CDC20;CDK1 spiperone PC3 DOWN 1/69 0.020524672 0.038312721 0 0 58.60588235 227.7499377 KIF20A clotrimazole CTD 00005691 1/70 0.02081953 0.038629008 0 0 57.75362319 223.6141611 CDK1 camptothecin BOSS 1/71 0.021114315 0.038927801 0 0 56.92571429 219.6082496 CDK1 Retinoic acid CTD 00006918 4/4258 0.021233346 0.038927801 0 0 7.400094029 28.50651206 CDC20;UBE2C;CDK1;KIF2C canavanine MCF7 DOWN 1/76 0.02258713 0.04116471 0 0 53.11733333 201.3346131 PBK mesalazine MCF7 DOWN 1/78 0.023175738 0.041988985 0 0 51.73246753 194.7545981 PBK rotenone BOSS 1/79 0.023469932 0.042027552 0 0 51.06666667 191.6039295 CDK1 ANTIMONY CTD 00005424 1/79 0.023469932 0.042027552 0 0 51.06666667 191.6039295 UBE2C Kinome 3629 Roche 1/80 0.023764052 0.042065103 0 0 50.41772152 188.5411675 CDK1 SILVER NITRATE CTD 00006743 1/80 0.023764052 0.042065103 0 0 50.41772152 188.5411675 CDK1 bay 11-7082 CTD 00003959 1/83 0.024645968 0.043376903 0 0 48.56585366 179.846251 CDK1 SILVER CTD 00006742 1/84 0.024939792 0.043644637 0 0 47.97831325 177.1018999 CDK1 adenine CTD 00005317 1/86 0.02552722 0.043938197 0 0 46.84470588 171.8268469 KIF20A Spectrum 001666 CTD 00000796 1/86 0.02552722 0.043938197 0 0 46.84470588 171.8268469 CDK1 Demecolcine CTD 00005762 2/876 0.025555632 0.043938197 0 0 10.9382151 40.10931418 UBE2C;CDK1 clotrimazole 1/87 0.025820823 0.043938197 0 0 46.29767442 169.2908728 CDK1 ANTIMONY POTASSIUM TARTRATE CTD 00005425 1/87 0.025820823 0.043938197 0 0 46.29767442 169.2908728 UBE2C fenofibrate CTD 00006620 1/90 0.026701191 0.044942194 0 0 44.73033708 162.0601184 CDK1 8-azaguanine HL60 DOWN 2/897 0.02672001 0.044942194 0 0 10.6698324 38.64978808 CDC20;KIF20A "7,8-Benzoflavone CTD 00000606" 1/91 0.026994499 0.044942194 0 0 44.23111111 159.7681765 CDK1 Bexarotene CTD 00003225 1/91 0.026994499 0.044942194 0 0 44.23111111 159.7681765 CDK1 pyrvinium MCF7 DOWN 1/92 0.027287734 0.044944504 0 0 43.74285714 157.5319375 KIF20A ellipticine CTD 00001632 1/92 0.027287734 0.044944504 0 0 43.74285714 157.5319375 CDK1 Cdk1/2 Inhibitor III RBC 1/95 0.028166997 0.045901773 0 0 42.34042553 151.1385651 CDK1 UNII-768N7QO4KH BOSS 1/95 0.028166997 0.045901773 0 0 42.34042553 151.1385651 CDK1 apigenin BOSS 1/97 0.028752804 0.046609809 0 0 41.45416667 147.1216655 CDK1 33258 Hoechst BOSS 1/99 0.029338317 0.047063551 0 0 40.60408163 143.2861545 CDK1 okadaic acid CTD 00007275 1/99 0.029338317 0.047063551 0 0 40.60408163 143.2861545 CDK1 phenoxybenzamine PC3 DOWN 1/104 0.030800813 0.04890026 0 0 38.62330097 134.4173604 KIF2C Decabromodiphenyl oxide CTD 00000574 1/104 0.030800813 0.04890026 0 0 38.62330097 134.4173604 UBE2C Imatinib CTD 00003267 1/105 0.031093092 0.04911114 0 0 38.25 132.756938 CDK1 kaempferol CTD 00000297 1/106 0.031385297 0.049319752 0 0 37.88380952 131.131615 CDK1 sertraline CTD 00007358 1/109 0.032261472 0.050439256 0 0 36.82592593 126.4558687 CDK1 docetaxel CTD 00002688 1/110 0.032553384 0.050638597 0 0 36.48623853 124.9607685 CDK1 thymidine BOSS 1/111 0.032845222 0.050835821 0 0 36.15272727 123.4958727 CDK1 apigenin CTD 00007429 1/112 0.033136987 0.051030959 0 0 35.82522523 122.0603112 CDK1 caffeine CTD 00005556 1/115 0.034011841 0.052117647 0 0 34.87719298 117.921413 CDK1 luteolin CTD 00007430 1/120 0.035468466 0.054080631 0 0 33.40336134 111.5375399 CDK1 cycloheximide BOSS 1/122 0.036050603 0.054697467 0 0 32.84793388 109.1481553 CDK1 "K-252a, Nocardiopsis sp. RBC" 1/126 0.037214 0.056185843 0 0 31.7904 104.6244399 PBK caffeine BOSS 1/127 0.037504666 0.056348473 0 0 31.53650794 103.543499 CDK1 harmine PC3 DOWN 1/133 0.039247128 0.058680171 0 0 30.09393939 97.44047473 KIF2C "3,4-DICHLOROANILINE CTD 00000754" 1/135 0.039827364 0.059260039 0 0 29.64179104 95.54145257 KIF20A MeIQx CTD 00001739 1/136 0.040117372 0.059404571 0 0 29.42074074 94.61550793 CDK1 colchicine CTD 00005701 1/140 0.041276677 0.060828787 0 0 28.56834532 91.06039121 KIF20A menadione CTD 00007386 2/1140 0.041763603 0.061230094 0 0 8.284710018 26.31000265 UBE2C;KIF2C genistein BOSS 1/143 0.042145389 0.061230094 0 0 27.96056338 88.54075844 CDK1 diuron CTD 00005864 1/143 0.042145389 0.061230094 0 0 27.96056338 88.54075844 KIF20A thioguanosine MCF7 DOWN 1/150 0.044169835 0.063571538 0 0 26.63758389 83.10162204 KIF2C thioguanosine PC3 DOWN 1/150 0.044169835 0.063571538 0 0 26.63758389 83.10162204 KIF2C vincristine CTD 00006988 2/1245 0.049105468 0.070346438 0 0 7.542638777 22.73189072 UBE2C;CDK1 captopril HL60 DOWN 1/170 0.049934328 0.071202652 0 0 23.46153846 70.31532368 KIF2C MG-132 CTD 00002789 1/173 0.050796498 0.071767529 0 0 23.04883721 68.68387239 CDC20 L-aspartic acid BOSS 1/173 0.050796498 0.071767529 0 0 23.04883721 68.68387239 CDK1 "O,P'-DDT CTD 00000838" 1/178 0.052231999 0.072363234 0 0 22.3920904 66.10279371 KIF20A GEMCITABINE HYDROCHLORIDE BOSS 1/179 0.052518882 0.072363234 0 0 22.26516854 65.60615648 CDK1 PhIP CTD 00002156 1/179 0.052518882 0.072363234 0 0 22.26516854 65.60615648 CDK1 dUTP BOSS 1/179 0.052518882 0.072363234 0 0 22.26516854 65.60615648 CDK1 "1,9-Pyrazoloanthrone CTD 00003948" 1/181 0.053092431 0.072363234 0 0 22.01555556 64.6315268 CDK1 L-threonine BOSS 1/181 0.053092431 0.072363234 0 0 22.01555556 64.6315268 CDK1 parthenolide HL60 DOWN 1/181 0.053092431 0.072363234 0 0 22.01555556 64.6315268 PBK arsenite CTD 00000779 2/1300 0.053140369 0.072363234 0 0 7.201848998 21.13611896 CDC20;CDK1 PROPIDIUM BOSS 1/182 0.053379097 0.072363234 0 0 21.89281768 64.15331309 CDK1 Melatonin BOSS 1/184 0.053952212 0.072363234 0 0 21.65136612 63.2145539 CDK1 ellagic acid BOSS 1/184 0.053952212 0.072363234 0 0 21.65136612 63.2145539 CDK1 GW-8510 PC3 DOWN 2/1312 0.05403748 0.072363234 0 0 7.13129771 20.80967868 KIF2C;KIF20A L-alanine BOSS 1/186 0.054525037 0.07270005 0 0 21.41513514 62.29866859 CDK1 Prestwick-983 HL60 UP 1/189 0.055383734 0.073096658 0 0 21.07021277 60.96601457 KIF20A ciglitazone CTD 00001835 1/190 0.055669822 0.073096658 0 0 20.95767196 60.53240181 CDK1 serine BOSS 1/191 0.055955837 0.073096658 0 0 20.84631579 60.10394169 CDK1 N-Acetyl-L-cysteine BOSS 1/191 0.055955837 0.073096658 0 0 20.84631579 60.10394169 CDK1 ipratropium bromide HL60 DOWN 1/192 0.056241781 0.073096658 0 0 20.73612565 59.68054719 CDK1 PLATINUM BOSS 1/194 0.056813451 0.073096658 0 0 20.51917098 58.84861646 CDK1 Aizen uranine BOSS 1/194 0.056813451 0.073096658 0 0 20.51917098 58.84861646 CDK1 furosemide BOSS 1/194 0.056813451 0.073096658 0 0 20.51917098 58.84861646 CDK1 2-Butanone BOSS 1/196 0.057384833 0.073096658 0 0 20.30666667 58.03595072 CDK1 water BOSS 1/196 0.057384833 0.073096658 0 0 20.30666667 58.03595072 CDK1 "Staurosporine, Streptomyces sp. RBC" 1/197 0.057670415 0.073096658 0 0 20.20204082 57.63664404 CDK1 tamoxifen BOSS 1/197 0.057670415 0.073096658 0 0 20.20204082 57.63664404 CDK1 doxorubicin BOSS 1/200 0.058526731 0.073878004 0 0 19.89447236 56.46591775 CDK1 temozolomide CTD 00002088 1/204 0.059667476 0.075010541 0 0 19.49852217 54.96571395 CDK1 dimethyl sulfoxide CTD 00005842 1/207 0.060522279 0.075775861 0 0 19.21165049 53.88375645 UBE2C Cube root extract CTD 00006707 1/211 0.061661008 0.07688903 0 0 18.84190476 52.49549691 CDK1 alsterpaullone MCF7 DOWN 2/1469 0.066306504 0.0823484 0 0 6.314587594 17.1344269 CDK1;KIF2C diethylstilbestrol CTD 00005818 1/233 0.067903483 0.083993063 0 0 17.0362069 45.8217398 CDC20 Aflodac CTD 00006817 1/234 0.068186407 0.084005653 0 0 16.96223176 45.55224378 CDK1 gemcitabine CTD 00002382 1/235 0.06846926 0.084018056 0 0 16.88888889 45.28536667 UBE2C quinpirole HL60 UP 1/245 0.071293856 0.087136935 0 0 16.18852459 42.75300511 KIF20A cantharidin HL60 DOWN 1/254 0.073829887 0.089879862 0 0 15.6055336 40.6678904 CDK1 curcumin BOSS 1/257 0.074673947 0.09054951 0 0 15.4203125 40.00991318 CDK1 trichostatin A CTD 00000660 3/3584 0.074978424 0.090562174 0 0 4.583356604 11.87343688 CDC20;CDK1;PBK PD 98059 CTD 00003206 1/262 0.076079289 0.091532895 0 0 15.1210728 38.95156908 CDK1 niclosamide HL60 DOWN 1/267 0.077482852 0.092858827 0 0 14.83308271 37.93855529 PBK "2-Nonenal, 4-hydroxy-, (2E,4R)- CTD 00001295" 1/274 0.079444855 0.094841145 0 0 14.44761905 36.59137122 CDC20 PHA-00665752 MCF7 DOWN 1/280 0.081123804 0.09647155 0 0 14.13261649 35.49800723 CDK1 OCHRATOXIN A CTD 00001202 1/297 0.085866972 0.101719336 0 0 13.30945946 32.6741376 CDK1 lycorine PC3 DOWN 1/302 0.087258132 0.102971282 0 0 13.08504983 31.91292546 KIF20A simvastatin CTD 00007319 1/304 0.087814102 0.103231845 0 0 12.99735974 31.61650878 CDK1 kojic acid CTD 00000624 1/313 0.090312475 0.10576518 0 0 12.61666667 30.33651858 PBK METHYL METHANESULFONATE CTD 00006307 3/3864 0.090671896 0.105783879 0 0 4.178451178 10.03040475 CDC20;KIF2C;KIF20A dexverapamil MCF7 DOWN 1/326 0.093911168 0.109149584 0 0 12.104 28.63087385 PBK thapsigargin PC3 DOWN 1/329 0.094739948 0.109698887 0 0 11.99146341 28.25931686 PBK mifepristone CTD 00007083 1/334 0.096119845 0.110783019 0 0 11.80840841 27.65717569 CDK1 amikacin PC3 DOWN 1/335 0.096395614 0.110783019 0 0 11.77245509 27.53924033 KIF2C clopamide HL60 DOWN 1/345 0.09914945 0.113524277 0 0 11.4244186 26.40328202 CDC20 vorinostat PC3 DOWN 1/355 0.101896288 0.116237247 0 0 11.0960452 25.34114547 KIF20A MG-262 PC3 DOWN 1/360 0.103267087 0.117366284 0 0 10.93871866 24.83566685 KIF20A MERCURY CTD 00006274 1/364 0.104362471 0.118175151 0 0 10.81597796 24.44286787 UBE2C 3'-Azido-3'-deoxythymidine CTD 00007047 1/374 0.107096053 0.120826317 0 0 10.52064343 23.50342411 CDK1 piperlongumine HL60 DOWN 1/389 0.111183389 0.124979868 0 0 10.10618557 22.19898739 PBK NICKEL CHLORIDE CTD 00001064 1/399 0.113899607 0.12756756 0 0 9.847236181 21.39250866 UBE2C Vorinostat CTD 00003560 1/425 0.120929422 0.134950224 0 0 9.231132075 19.50121142 CDK1 emetine HL60 DOWN 1/435 0.123620791 0.137455609 0 0 9.013824885 18.84373023 PBK ajmaline HL60 DOWN 1/496 0.139889891 0.154985923 0 0 7.878383838 15.49599046 CDC20 3-(1-methylpyrrolidin-2-yl)pyridine CTD 00006393 1/499 0.140683472 0.155306485 0 0 7.829718876 15.35597972 UBE2C GDC-0941 CTD 00004868 1/533 0.149634823 0.164012546 0 0 7.316541353 13.89819075 CDK1 testosterone enanthate CTD 00000155 1/533 0.149634823 0.164012546 0 0 7.316541353 13.89819075 CDK1 POTASSIUM DICHROMATE CTD 00006598 1/556 0.155645978 0.169996316 0 0 7.005045045 13.03058322 UBE2C cytarabine CTD 00005743 1/594 0.165499858 0.180119987 0 0 6.543338954 11.77005959 UBE2C sulpiride PC3 DOWN 1/617 0.171417354 0.185805336 0 0 6.291558442 11.09613238 CDK1 methotrexate CTD 00006299 1/619 0.171930262 0.185805336 0 0 6.270550162 11.04034657 UBE2C ambroxol PC3 DOWN 1/622 0.172699128 0.185983677 0 0 6.239291465 10.95747076 UBE2C raloxifene CTD 00007367 1/686 0.188960452 0.202786827 0 0 5.637664234 9.393574998 KIF20A meclofenoxate HL60 DOWN 1/713 0.195740342 0.209333422 0 0 5.416292135 8.833789845 KIF2C ampyrone HL60 DOWN 1/781 0.212606657 0.226584257 0 0 4.926666667 7.628014669 KIF2C tamoxifen CTD 00006827 1/802 0.217755398 0.23127125 0 0 4.792259675 7.305238579 CDK1 ARSENIC CTD 00005442 1/853 0.230142793 0.243587561 0 0 4.49342723 6.601093184 CDK1 Bortezomib CTD 00003736 1/878 0.236155073 0.249095078 0 0 4.35963512 6.292115751 CDK1 Silica CTD 00006678 1/898 0.240936679 0.253271321 0 0 4.257971014 6.060034291 CDK1 cimetidine PC3 DOWN 1/953 0.253957657 0.266050879 0 0 4.000420168 5.4829268 KIF2C irinotecan PC3 DOWN 1/999 0.264704489 0.276369433 0 0 3.806813627 5.059792868 KIF2C diazinon CTD 00005790 1/1027 0.271182645 0.282176536 0 0 3.697465887 4.825055136 CDC20 anisomycin HL60 DOWN 1/1034 0.27279473 0.282898239 0 0 3.671055179 4.768831625 CDC20 GW-8510 MCF7 DOWN 1/1290 0.329744152 0.340809392 0 0 2.902249806 3.219866865 CDC20 TERT-BUTYL HYDROPEROXIDE CTD 00007349 1/1341 0.340633113 0.350886284 0 0 2.784179104 2.998419723 UBE2C H-7 PC3 DOWN 1/1361 0.344862854 0.354059197 0 0 2.740294118 2.917340313 CDK1 Disodium selenite CTD 00007229 1/1370 0.346758847 0.354823007 0 0 2.720964207 2.881843135 UBE2C camptothecin MCF7 DOWN 1/1513 0.376276111 0.383751795 0 0 2.444708995 2.389536967 KIF2C SELENIUM CTD 00006731 1/1559 0.385531437 0.391893342 0 0 2.366623877 2.255706226 CDK1 Decitabine CTD 00000750 1/1800 0.432172313 0.437858791 0 0 2.022790439 1.696981397 CDK1 VALPROIC ACID CTD 00006977 3/8312 0.488004306 0.492804348 0 0 1.406306415 1.008927887 PBK;KIF2C;KIF20A ETHYL METHANESULFONATE CTD 00005938 1/2315 0.522021534 0.52543344 0 0 1.528089888 0.99332939 KIF20A atrazine CTD 00005450 1/2968 0.618619982 0.620635031 0 0 1.147758679 0.551227309 PBK formaldehyde CTD 00006001 1/3192 0.647746533 0.647746533 0 0 1.053149483 0.457336284 CDC20