CCT,SMILES,BCL6 TR-FRET IC50 Geometric Mean (nM),MSD degrader assay [OCI-LY1] DC50 Geometric Mean (nM)
2 (CCT369260),C[C@@H]1CN(C[C@H](C)C1(F)F)c1ncc(c(n1)Nc1ccc2c(c1)N(CCC(C)(C)O)C(=O)N2C)Cl,522.7,54.4
3,CN1C(=O)N(CCC(C)(C)O)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC(F)(F)C(O)C1,237.6,275.9
4,CN1C(=O)N(CCC(C)(C)O)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC(F)(F)C(CO)C1,86.1,80.2
5,C[C@@H]1C[C@H](O)CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)N(CCC(C)(C)O)C(=O)N2C)Cl,95.1,34.5
8a,CN1C(=O)C2=C(N[C@@H](C3CC3)C(F)(F)CO2)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC(F)(F)[C@@H](O)C1,3.5,7.1
8b,CN1C(=O)C2=C(N[C@@H](C3CC3)C(F)(F)CO2)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC(F)(F)[C@H](O)C1,4.6,>2000
9a,CN1C(=O)C2=C(N[C@@H](C3CC3)C(F)(F)CO2)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC(F)(F)[C@@H](CO)C1,1.5,2.7
9b,CN1C(=O)C2=C(N[C@@H](C3CC3)C(F)(F)CO2)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC(F)(F)[C@H](CO)C1,4.1,>2000
10a,C[C@H]1C[C@H](CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl)NC(=O)C,3.6,2.2
10b,C[C@@H]1C[C@@H](CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl)NC(=O)C,2.9,>2000
11a,C[C@H]1C[C@H](CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl)N(C)C,3.3,9.8
11b,C[C@@H]1C[C@@H](CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl)N(C)C,3.6,>2000
12a (CCT373566),C[C@H]1C[C@@H](O)CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl,2.2,0.7
12b (CCT373567),C[C@@H]1C[C@H](O)CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl,2.8,>2000
13a,C[C@@H]1C[C@@H](O)CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl,9.9,>2000
13b,C[C@H]1C[C@H](O)CN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl,6,>2000
14a,CN1C(=O)C2=C(N[C@@H](C3CC3)C(F)(F)CO2)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC[C@@H](O)C1,2.5,>2000
14b,CN1C(=O)C2=C(N[C@@H](C3CC3)C(F)(F)CO2)c2cc(ccc21)Nc1nc(ncc1Cl)N1CCC[C@H](O)C1,3,>2000
15a,C[C@H]1CCCN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl,36.5,6.3
15b,C[C@@H]1CCCN(C1)c1ncc(c(n1)Nc1ccc2c(c1)C1=C(OCC(F)(F)[C@@H](N1)C1CC1)C(=O)N2C)Cl,24.6,32.6