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clearfix"> <div class="panel-display panels-960-layout jcore-2col-layout"> <div class="panel-row-wrapper panel-row-first clearfix"> <div class="top-wrapper"> <div class="panel-panel panel-region-top"> <div class="inside"> <div class="panel-pane pane-highwire-article-citation no-margin-bottom"> <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node46649" data-apath="/clinjasn/early/2022/04/06/CJN.01230122.atom" data-hw-author-tooltip-instance="highwire_author_tooltip" data-node-nid="46649" data-pisa="clinjasn;CJN.01230122v1" data-pisa-master="clinjasn;CJN.01230122" id="node46649--21350661347"> <div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-asnjnls-styles-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a"> <div class="highwire-cite-overline"> <span class="highwire-cite-metadata-art-cat highwire-cite-metadata">Research</span> </div> <div class="highwire-cite-access"> <span class="highwire-citation-access highwire-citation-access-check" data-atom-uri="/clinjasn/early/2022/04/06/CJN.01230122.atom" data-pisa-id="clinjasn;CJN.01230122" data-request-view="full"> <i aria-hidden="true" class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" style="display:none;" title="You have access"/> <span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span> <i aria-hidden="true" class="highwire-access-icon highwire-access-icon-no-access no-access icon-lock" style="display:none;" title="Restricted Access"/> <span class="element-invisible highwire-access-icon highwire-access-icon-no-access" style="display:none;">Restricted Access</span> </span> </div> <h1 class="highwire-cite-title" id="page-title">PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function</h1> <div class="highwire-cite-authors"> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Azin Kheirkhah</span>, <span class="highwire-citation-author" data-delta="1">Claudia Lamina</span>, <span class="highwire-citation-author" data-delta="2">Barbara Kollerits</span>, <span class="highwire-citation-author" data-delta="3">Johanna Schachtl-Riess</span>, <span class="highwire-citation-author" data-delta="4">Ulla Schultheiss</span>, <span class="highwire-citation-author" data-delta="5">Lukas Forer</span>, <span class="highwire-citation-author" data-delta="6">Peggy Sekula</span>, <span class="highwire-citation-author" data-delta="7">Fruzsina Kotsis</span>, <span class="highwire-citation-author" data-delta="8">Kai-Uwe Eckardt</span> and <span class="highwire-citation-author" data-delta="9">Florian Kronenberg</span></span> </div> <div class="highwire-cite-metadata"> <span class="highwire-cite-metadata-journal highwire-cite-metadata">CJASN </span> <span class="highwire-cite-metadata-date highwire-cite-metadata">April 2022, </span> <span class="highwire-cite-metadata-pages highwire-cite-metadata">CJN.01230122; </span> <span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.2215/CJN.01230122 </span> </div> </div> <div id="hw-article-author-popups-node46649--21350661347" style="display: none;"> <div class="author-tooltip-0"> <div class="author-tooltip-name">Azin Kheirkhah </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">A Kheirkhah, Institute of Genetic Epidemiology, <span class="nlm-institution">Medical University of Innsbruck</span>, Innsbruck, <span class="nlm-country">Austria</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-1"> <div class="author-tooltip-name">Claudia Lamina </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">C Lamina, Institute of Genetic Epidemiology, <span class="nlm-institution">Medical University of Innsbruck</span>, Innsbruck, <span class="nlm-country">Austria</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-2"> <div class="author-tooltip-name">Barbara Kollerits </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">B Kollerits, Institute of Genetic Epidemiology, <span class="nlm-institution">Medical University of Innsbruck</span>, Innsbruck, <span class="nlm-country">Austria</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-3"> <div class="author-tooltip-name">Johanna Schachtl-Riess </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">J Schachtl-Riess, Institute of Genetic Epidemiology, <span class="nlm-institution">Medical University of Innsbruck</span>, Innsbruck, <span class="nlm-country">Austria</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-4"> <div class="author-tooltip-name">Ulla Schultheiss </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">U Schultheiss, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, <span class="nlm-institution">University of Freiburg</span>, Freiburg im Breisgau, <span class="nlm-country">Germany</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-5"> <div class="author-tooltip-name">Lukas Forer </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">L Forer, Institute of Genetic Epidemiology, <span class="nlm-institution">Medical University of Innsbruck</span>, Innsbruck, <span class="nlm-country">Austria</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-6"> <div class="author-tooltip-name">Peggy Sekula </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">P Sekula, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, <span class="nlm-institution">University of Freiburg</span>, Freiburg im Breisgau, <span class="nlm-country">Germany</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-7"> <div class="author-tooltip-name">Fruzsina Kotsis </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">F Kotsis, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, <span class="nlm-institution">University of Freiburg</span>, Freiburg im Breisgau, <span class="nlm-country">Germany</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-8"> <div class="author-tooltip-name">Kai-Uwe Eckardt </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">K Eckardt, University Hospital Erlangen, Department of Nephrology and Hypertension, <span class="nlm-institution">Friedrich-Alexander-Universität Erlangen-Nürnberg</span>, Erlangen, <span class="nlm-country">Germany</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link last">Search for this author on this site</li> </ul> </div> <div class="author-tooltip-9"> <div class="author-tooltip-name">Florian Kronenberg </div> <div class="author-tooltip-affiliation"> <span class="author-tooltip-text"> <div class="author-affiliation">F Kronenberg, Institute of Genetic Epidemiology, <span class="nlm-institution">Medical University of Innsbruck</span>, Innsbruck, <span class="nlm-country">Austria</span></div> </span> </div> <ul class="author-tooltip-find-more"> <li class="author-tooltip-gs-link first">Find this author on Google Scholar</li> <li class="author-tooltip-pubmed-link">Find this author on PubMed</li> <li class="author-site-search-link">Search for this author on this site</li> <li class="author-corresp-email-link last"> <span>For correspondence: Florian.Kronenberg@i-med.ac.at</span> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="panel-row-wrapper clearfix"> <div class="main-content-wrapper grid-17 suffix-1 alpha"> <div class="panel-panel panel-region-content"> <div class="inside"> <div class="panel-pane pane-highwire-markup border-top-hairline"> <div class="pane-content"> <div class="highwire-markup"> <div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="content-block-markup"> <div> <span class="highwire-journal-article-marker-start"/> <div class="auto-clean"> <span style="font-family: Verdana,Arial,Helvetica,sans-serif; font-size: 83.33%"> <h2>Supplemental 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