Supplementary Data 3: GO term and KEGG pathway enrichment of cluster-defining genes.,,,,,,,,,,,,,
MarkerGeneSet,Category,Term,Count,%,PValue,Genes,List Total,Pop Hits,Pop Total,Fold Enrichment,Bonferroni,Benjamini,FDR
MEL,GOTERM_CC_DIRECT,GO:0042470~melanosome,9,9.183673469,5.96E-08,"PMEL, GPR143, DCT, MLANA, HPS4, RAB27A, SLC1A4, TYR, SLC24A5",97,101,18224,16.74145146,1.01E-05,1.01E-05,9.90E-06
MEL,GOTERM_BP_DIRECT,GO:0030318~melanocyte differentiation,6,6.12244898,6.43E-08,"OCA2, EDNRB, HPS4, RAB27A, MITF, SOX10",93,20,16792,54.16774194,5.11E-05,5.10E-05,5.10E-05
MEL,GOTERM_CC_DIRECT,GO:0033162~melanosome membrane,5,5.102040816,2.32E-07,"OCA2, GPR143, SLC45A2, DCT, TYR",97,11,18224,85.39831303,3.94E-05,1.97E-05,1.93E-05
MEL,GOTERM_BP_DIRECT,GO:0042438~melanin biosynthetic process,5,5.102040816,5.81E-07,"OCA2, PMEL, SLC45A2, DCT, TYR",93,13,16792,69.44582299,4.62E-04,2.31E-04,2.31E-04
MEL,GOTERM_BP_DIRECT,GO:0006726~eye pigment biosynthetic process,3,3.06122449,1.77E-04,"OCA2, GPR143, TYR",93,4,16792,135.4193548,0.131194961,0.046815735,0.046815735
MEL,GOTERM_MF_DIRECT,GO:0042803~protein homodimerization activity,13,13.26530612,3.53E-04,"SCARB1, BCL2A1, HPS4, TYR, RENBP, RAP1GAP, P2RX7, CEACAM1, NR4A3, GJB1, ERBB3, APOE, IL6R",88,730,16881,3.41614259,0.080901282,0.084346856,0.084346856
MEL,GOTERM_CC_DIRECT,GO:0005887~integral component of plasma membrane,19,19.3877551,3.80E-04,"SCARB1, PMEL, SEMA6A, SLC1A4, GPR137B, TSPAN10, BEST1, P2RX7, TRPM1, SLC7A5, CEACAM1, EDNRB, ERBB3, MLANA, SLC16A6, TNFRSF14, PLXNC1, SLC24A5, SLC19A2",97,1415,18224,2.522720484,0.06258041,0.021537338,0.021030577
MEL,GOTERM_BP_DIRECT,GO:0048066~developmental pigmentation,3,3.06122449,6.12E-04,"PMEL, SLC45A2, DCT",93,7,16792,77.38248848,0.38558344,0.121580117,0.121580117
MEL,GOTERM_BP_DIRECT,GO:0007399~nervous system development,8,8.163265306,0.001005411,"IGSF8, SLC7A5, HES6, GJB1, SEMA6A, EDNRB, GPM6B, GAS7",93,287,16792,5.033007381,0.55053797,0.159659281,0.159659281
MEL,GOTERM_CC_DIRECT,GO:0005764~lysosome,7,7.142857143,0.00124697,"ASAH1, RRAGD, HPS4, RAB27A, ACP5, TYR, SNCA",97,226,18224,5.819177082,0.191130085,0.052996223,0.051749253
MEL,GOTERM_CC_DIRECT,GO:0005794~Golgi apparatus,13,13.26530612,0.001896626,"PMEL, GALNT3, SORT1, RAB27A, RNF144A, GPR143, MLANA, AP1S2, ST3GAL6, BIRC7, APOE, ST6GALNAC3, SNCA",97,863,18224,2.830117906,0.275832548,0.064485296,0.062967994
MEL,GOTERM_CC_DIRECT,GO:0005886~plasma membrane,35,35.71428571,0.002900698,"IGSF8, PMEL, SCARB1, IGSF3, TTYH2, SLC1A4, FMN1, APOLD1, BEST1, TRPM1, EDNRB, ERBB3, MCF2L, CAPN3, MBP, TNFRSF14, APOE, PLXNC1, STK32A, IL6R, GPM6B, CA14, SLC19A2, SNCA, SORT1, IL16, IGSF11, P2RX7, RNF144A, SLC7A5, GPR143, CEACAM1, PLP1, SGK1, ITGA9",97,4121,18224,1.595649139,0.389718707,0.079588978,0.077716296
MEL,GOTERM_CC_DIRECT,GO:0005765~lysosomal membrane,7,7.142857143,0.003277193,"OCA2, SCARB1, GPR143, SORT1, AP1S2, MFSD12, GPR137B",97,274,18224,4.799759199,0.427668978,0.079588978,0.077716296
MEL,GOTERM_CC_DIRECT,GO:0016324~apical plasma membrane,7,7.142857143,0.004394417,"SLC7A5, GPR143, CEACAM1, ERBB3, RAB27A, IL6R, LZTS1",97,291,18224,4.519360896,0.527017598,0.093381356,0.091184147
MEL,GOTERM_BP_DIRECT,GO:0007422~peripheral nervous system development,3,3.06122449,0.007577064,"EDNRB, ERBB3, SOX10",93,24,16792,22.56989247,0.997634351,0.883960228,0.883960228
MEL,GOTERM_BP_DIRECT,GO:0030334~regulation of cell migration,4,4.081632653,0.0077931,"CEACAM1, LAMA1, PLXNC1, SGK1",93,74,16792,9.759953502,0.998010321,0.883960228,0.883960228
MEL,GOTERM_BP_DIRECT,GO:0045601~regulation of endothelial cell differentiation,2,2.040816327,0.010927906,"CEACAM1, APOLD1",93,2,16792,180.5591398,0.999839225,0.903070306,0.903070306
MEL,GOTERM_BP_DIRECT,GO:0006583~melanin biosynthetic process from tyrosine,2,2.040816327,0.010927906,"DCT, TYR",93,2,16792,180.5591398,0.999839225,0.903070306,0.903070306
MEL,GOTERM_BP_DIRECT,GO:0050830~defense response to Gram-positive bacterium,4,4.081632653,0.011373681,"P2RX7, ACP5, TNFRSF14, IL6R",93,85,16792,8.496900696,0.99988765,0.903070306,0.903070306
MEL,KEGG_PATHWAY,hsa04916:Melanogenesis,4,4.081632653,0.015040007,"EDNRB, DCT, MITF, TYR",37,100,6879,7.436756757,0.659027049,0.776050192,0.776050192
MEL,GOTERM_BP_DIRECT,GO:0051612~negative regulation of serotonin uptake,2,2.040816327,0.016347479,"GPM6B, SNCA",93,3,16792,120.3727599,0.999997962,1,1
MEL,GOTERM_BP_DIRECT,GO:0007166~cell surface receptor signaling pathway,6,6.12244898,0.017358394,"P2RX7, SEMA6A, EDNRB, LAMA1, TNFRSF14, TSPAN10",93,274,16792,3.953849776,0.9999991,1,1
MEL,GOTERM_BP_DIRECT,GO:0042157~lipoprotein metabolic process,3,3.06122449,0.018366866,"SCARB1, APOE, APOLD1",93,38,16792,14.25466893,0.999999602,1,1
MEL,GOTERM_CC_DIRECT,GO:0005667~transcription factor complex,5,5.102040816,0.019036756,"IVNS1ABP, NR4A1, HES6, NR4A3, CDK2",97,193,18224,4.867261364,0.961896491,0.3295556,0.32180135
MEL,GOTERM_CC_DIRECT,GO:0016021~integral component of membrane,38,38.7755102,0.019385624,"IGSF8, OCA2, PMEL, SCARB1, SLC45A2, IGSF3, FAM69B, SLC1A4, APOLD1, TSPAN10, BEST1, TRPM1, EDNRB, ERBB3, SLC16A6, ACP5, ST3GAL6, TNFRSF14, IL6R, GPM6B, CA14, SLC19A2, SEMA6A, GALNT3, SORT1, TYR, MFSD12, GPR137B, IGSF11, RNF144A, SLC7A5, GPR143, CEACAM1, GJB1, DCT, PLP1, ST6GALNAC3, SLC24A5",97,5163,18224,1.382781129,0.964132301,0.3295556,0.32180135
MEL,GOTERM_BP_DIRECT,GO:0032400~melanosome localization,2,2.040816327,0.021737677,"GPR143, RAB27A",93,4,16792,90.27956989,0.999999974,1,1
MEL,GOTERM_BP_DIRECT,GO:0007601~visual perception,5,5.102040816,0.024610788,"TRPM1, GPR143, SLC45A2, TYR, BEST1",93,201,16792,4.49152089,0.999999998,1,1
MEL,KEGG_PATHWAY,hsa04142:Lysosome,4,4.081632653,0.024860588,"ASAH1, SORT1, AP1S2, ACP5",37,121,6879,6.146079964,0.832607351,0.776050192,0.776050192
MEL,GOTERM_BP_DIRECT,GO:0001755~neural crest cell migration,3,3.06122449,0.025235191,"SEMA6A, EDNRB, SOX10",93,45,16792,12.03727599,0.999999999,1,1
MEL,GOTERM_CC_DIRECT,GO:0043025~neuronal cell body,6,6.12244898,0.025519656,"P2RX7, SORT1, MBP, SLC1A4, APOE, RAP1GAP",97,315,18224,3.578595974,0.987656901,0.394394681,0.385114806
MEL,GOTERM_BP_DIRECT,GO:0051055~negative regulation of lipid biosynthetic process,2,2.040816327,0.027098657,"CEACAM1, APOE",93,5,16792,72.22365591,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0015293~symporter activity,3,3.06122449,0.028434901,"SLC16A6, SLC1A4, SLC24A5",88,51,16881,11.28409091,0.998986589,1,1
MEL,GOTERM_MF_DIRECT,GO:0005254~chloride channel activity,3,3.06122449,0.031599801,"TTYH2, SLC1A4, BEST1",88,54,16881,10.65719697,0.999535363,1,1
MEL,GOTERM_MF_DIRECT,GO:0017137~Rab GTPase binding,4,4.081632653,0.031981773,"MICAL1, TBC1D7, HPS4, TBC1D16",88,134,16881,5.726255088,0.999577171,1,1
MEL,KEGG_PATHWAY,hsa04151:PI3K-Akt signaling pathway,6,6.12244898,0.032335425,"NR4A1, LAMA1, CDK2, SGK1, IL6R, ITGA9",37,345,6879,3.233372503,0.903068749,0.776050192,0.776050192
MEL,GOTERM_BP_DIRECT,GO:0071376~cellular response to corticotropin-releasing hormone stimulus,2,2.040816327,0.032430576,"NR4A1, NR4A3",93,6,16792,60.18637993,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0034384~high-density lipoprotein particle clearance,2,2.040816327,0.032430576,"SCARB1, APOE",93,6,16792,60.18637993,1,1,1
MEL,GOTERM_CC_DIRECT,GO:0005769~early endosome,5,5.102040816,0.032918565,"ZFYVE16, SORT1, APOE, RAP1GAP, TBC1D16",97,229,18224,4.102102372,0.996621547,0.466346335,0.45537348
MEL,GOTERM_MF_DIRECT,GO:0005507~copper ion binding,3,3.06122449,0.033783433,"DCT, TYR, SNCA",88,56,16881,10.27658279,0.999729105,1,1
MEL,GOTERM_BP_DIRECT,GO:0043524~negative regulation of neuron apoptotic process,4,4.081632653,0.035941983,"NR4A3, ERBB3, APOE, SNCA",93,132,16792,5.471489084,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0008366~axon ensheathment,2,2.040816327,0.03773359,"PLP1, MBP",93,7,16792,51.58832565,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0035726~common myeloid progenitor cell proliferation,2,2.040816327,0.03773359,"CEACAM1, NR4A3",93,7,16792,51.58832565,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0032808~lacrimal gland development,2,2.040816327,0.03773359,"IGSF3, SOX10",93,7,16792,51.58832565,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0005515~protein binding,55,56.12244898,0.037838272,"SCARB1, PRDM7, FAM69B, EDNRB, TRIM2, CHCHD6, AP1S2, CAPN3, PLXNC1, SOX6, LZTS1, IL6R, TRIM63, SEMA6A, MITF, SOX10, RUNX3, SHTN1, CEACAM1, ZFYVE16, IRF4, RRAGD, TBC1D7, BIRC7, SGK1, GAS7, IGSF8, OCA2, PMEL, TTYH2, BCL2A1, LAMA1, RAP1GAP, ERBB3, MLANA, MICAL1, MBP, TNFRSF14, APOE, LONRF1, TBC1D16, SLC19A2, SNCA, SORT1, HPS4, RAB27A, CABLES1, TYR, P2RX7, NR4A1, GPR143, NR4A3, CDK2, PIR, PLP1",88,8785,16881,1.200981787,0.99990085,1,1
MEL,GOTERM_MF_DIRECT,GO:0046983~protein dimerization activity,4,4.081632653,0.042434743,"HES6, CEACAM1, HPS4, MITF",88,150,16881,5.115454545,0.999968432,1,1
MEL,GOTERM_BP_DIRECT,GO:0014902~myotube differentiation,2,2.040816327,0.043007853,"MYEF2, SORT1",93,8,16792,45.13978495,1,1,1
MEL,GOTERM_BP_DIRECT,GO:2001224~positive regulation of neuron migration,2,2.040816327,0.043007853,"SHTN1, SEMA6A",93,8,16792,45.13978495,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0019934~cGMP-mediated signaling,2,2.040816327,0.043007853,"EDNRB, APOE",93,8,16792,45.13978495,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0061469~regulation of type B pancreatic cell proliferation,2,2.040816327,0.043007853,"NR4A1, NR4A3",93,8,16792,45.13978495,1,1,1
MEL,GOTERM_CC_DIRECT,GO:0032585~multivesicular body membrane,2,2.040816327,0.046433188,"PMEL, RAB27A",97,9,18224,41.75028637,0.99969119,0.607203229,0.592916094
MEL,GOTERM_BP_DIRECT,GO:0008217~regulation of blood pressure,3,3.06122449,0.049433018,"EDNRB, SGK1, RENBP",93,65,16792,8.333498759,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0019911~structural constituent of myelin sheath,2,2.040816327,0.050371391,"PLP1, MBP",88,10,16881,38.36590909,0.999995681,1,1
MEL,GOTERM_BP_DIRECT,GO:0043154~negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,3,3.06122449,0.054983219,"NR4A1, MICAL1, SNCA",93,69,16792,7.850397382,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0048156~tau protein binding,2,2.040816327,0.055268414,"APOE, SNCA",88,11,16881,34.87809917,0.999998745,1,1
MEL,GOTERM_BP_DIRECT,GO:0010628~positive regulation of gene expression,5,5.102040816,0.055854808,"P2RX7, ERBB3, PLP1, RAB27A, MITF",93,262,16792,3.44578511,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0048484~enteric nervous system development,2,2.040816327,0.058659679,"EDNRB, SOX10",93,11,16792,32.82893451,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0006707~cholesterol catabolic process,2,2.040816327,0.058659679,"SCARB1, APOE",93,11,16792,32.82893451,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0031402~sodium ion binding,2,2.040816327,0.060140474,"CAPN3, SLC24A5",88,12,16881,31.97159091,0.999999635,1,1
MEL,GOTERM_BP_DIRECT,GO:0032496~response to lipopolysaccharide,4,4.081632653,0.061223809,"P2RX7, ACP5, TNFRSF14, SNCA",93,164,16792,4.403881458,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0031432~titin binding,2,2.040816327,0.069810204,"TRIM63, CAPN3",88,14,16881,27.40422078,0.999999969,1,1
MEL,GOTERM_BP_DIRECT,GO:0001503~ossification,3,3.06122449,0.071285729,"SORT1, RUNX3, GPM6B",93,80,16792,6.770967742,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0042060~wound healing,3,3.06122449,0.071285729,"SCARB1, ERBB3, ITGA9",93,80,16792,6.770967742,1,1,1
MEL,KEGG_PATHWAY,hsa05222:Small cell lung cancer,3,3.06122449,0.072542835,"LAMA1, CDK2, BIRC7",37,85,6879,6.561844197,0.995237181,1,1
MEL,GOTERM_BP_DIRECT,GO:0042311~vasodilation,2,2.040816327,0.074058252,"EDNRB, APOE",93,14,16792,25.79416283,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0034375~high-density lipoprotein particle remodeling,2,2.040816327,0.079135535,"SCARB1, APOE",93,15,16792,24.07455197,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0042127~regulation of cell proliferation,4,4.081632653,0.081283224,"ERBB3, TNFRSF14, BIRC7, SGK1",93,185,16792,3.903981401,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0016491~oxidoreductase activity,4,4.081632653,0.084463487,"DCT, MICAL1, TYR, SNCA",88,200,16881,3.836590909,0.999999999,1,1
MEL,GOTERM_MF_DIRECT,GO:0004842~ubiquitin-protein transferase activity,5,5.102040816,0.090097518,"RNF144A, TRIM63, TRIM2, BIRC7, LONRF1",88,329,16881,2.915342636,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0046982~protein heterodimerization activity,6,6.12244898,0.092087677,"NR4A1, ERBB3, BCL2A1, RRAGD, SOX6, TYR",88,465,16881,2.475219941,1,1,1
MEL,GOTERM_BP_DIRECT,GO:1902476~chloride transmembrane transport,3,3.06122449,0.092269776,"TTYH2, SLC1A4, BEST1",93,93,16792,5.82448838,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0008373~sialyltransferase activity,2,2.040816327,0.093556386,"ST3GAL6, ST6GALNAC3",88,19,16881,20.19258373,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0001574~ganglioside biosynthetic process,2,2.040816327,0.094202734,"ST3GAL6, ST6GALNAC3",93,18,16792,20.06212664,1,1,1
MEL,GOTERM_BP_DIRECT,GO:0043691~reverse cholesterol transport,2,2.040816327,0.094202734,"SCARB1, APOE",93,18,16792,20.06212664,1,1,1
MEL,GOTERM_MF_DIRECT,GO:0005545~1-phosphatidylinositol binding,2,2.040816327,0.098233209,"SCARB1, ZFYVE16",88,20,16881,19.18295455,1,1,1
MES,GOTERM_CC_DIRECT,GO:0005615~extracellular space,42,28.18791946,4.74E-14,"NRP1, CFH, CSF1, COL12A1, SERPINE1, TNFAIP2, LTBP2, TFPI, CLU, EGFR, LOXL2, FGF5, SRPX2, PLAU, PODXL, STC2, PDGFC, CCL2, SPOCK1, SLIT2, IGFBP6, CPA4, CCBE1, WNT5B, ANGPT1, WNT5A, VEGFC, NRG1, SERPINB7, F3, DKK3, COL1A1, VCAN, LOX, AXL, COL6A2, PAPPA, PXDN, CDH13, TGFBI, GAS6, FBN1",148,1347,18224,3.839402877,9.24E-12,8.43E-12,7.35E-12
MES,GOTERM_BP_DIRECT,GO:0030198~extracellular matrix organization,19,12.75167785,7.45E-14,"ITGB1, COL13A1, ITGA2, SERPINE1, CYR61, COL1A1, VCAN, CCDC80, COL5A1, LOX, COL6A2, COL6A1, ITGA11, PXDN, COL8A1, TGFBI, SOX9, ITGA5, FBN1",145,196,16792,11.22617875,1.08E-10,1.08E-10,1.05E-10
MES,GOTERM_CC_DIRECT,GO:0005925~focal adhesion,24,16.10738255,8.65E-14,"ITGB1, NRP1, FZD2, SDC4, ITGA2, CAV1, FHL1, RRAS2, AFAP1, LMO7, RND3, EGFR, CNN2, ALCAM, CDH2, RRAS, PLAU, ITGA11, RAC2, CDH13, FLNC, ITGA5, TGM2, EPHA2",148,391,18224,7.558166863,1.69E-11,8.43E-12,7.35E-12
MES,GOTERM_CC_DIRECT,GO:0031012~extracellular matrix,21,14.09395973,3.17E-13,"COL12A1, SERPINE1, LTBP2, ADAMTS12, CLU, F3, LTBP1, THSD4, CYR61, LOXL2, COL1A1, VCAN, COL5A1, COL6A2, COL6A1, PXDN, COL8A1, TGFBI, EDIL3, TGM2, FBN1",148,296,18224,8.735938641,6.19E-11,2.06E-11,1.80E-11
MES,GOTERM_BP_DIRECT,GO:0007155~cell adhesion,25,16.77852349,1.08E-12,"NTM, COL12A1, RND3, CYR61, LOXL2, ALCAM, CDH2, PODXL, CCL2, SPOCK1, EDIL3, ITGA2, TPBG, COL1A1, VCAN, COL5A1, COL6A2, COL6A1, ITGA11, ADAM12, COL8A1, CDH13, TGFBI, ITGA5, GAS6",145,459,16792,6.307565172,1.57E-09,7.83E-10,7.64E-10
MES,GOTERM_CC_DIRECT,GO:0005576~extracellular region,43,28.8590604,3.72E-12,"PTGFR, CFH, COL13A1, COL12A1, SERPINE1, NTN4, ANTXR2, TFPI, LTBP1, CLU, CYR61, FGF5, GLIPR1, ESM1, PLAU, STC2, PDGFC, CCL2, SLIT2, IGFBP6, EPHB2, GBP1, WNT5B, ANGPT1, BDNF, HEG1, WNT5A, CRIM1, VEGFC, NRG1, DKK3, COL1A1, VCAN, COL5A1, LOX, COL6A2, PAPPA, COL6A1, ADAM12, COL8A1, TGFBI, GAS6, FBN1",148,1610,18224,3.288702367,7.24E-10,1.81E-10,1.58E-10
MES,GOTERM_CC_DIRECT,GO:0005578~proteinaceous extracellular matrix,17,11.40939597,5.33E-10,"CCBE1, WNT5B, WNT5A, LTBP2, ADAMTS12, LTBP1, CYR61, VCAN, COL5A1, LOX, COL6A2, PXDN, SPOCK1, TGFBI, SLIT2, ADAMTS6, FBN1",148,268,18224,7.810810811,1.04E-07,2.08E-08,1.81E-08
MES,GOTERM_MF_DIRECT,GO:0005178~integrin binding,12,8.053691275,1.19E-09,"ITGB1, ESM1, COL5A1, ITGA2, NRG1, TGFBI, ITGA5, PLPP3, EDIL3, CYR61, EGFR, FBN1",142,105,16881,13.58631791,3.85E-07,3.85E-07,3.74E-07
MES,GOTERM_CC_DIRECT,GO:0070062~extracellular exosome,53,35.5704698,1.92E-09,"ITGB1, CSF1, COL12A1, SERPINE1, RND3, CLU, MYLK, ALCAM, CDH2, BASP1, PLAU, RAC2, AOX1, EDIL3, TGM2, SLC38A1, WNT5B, WNT5A, KRT8, RRAS2, LIFR, F3, DDAH1, COL6A2, COL6A1, PXDN, KCNMA1, FSCN1, COL8A1, CDH13, PLPP3, GAS6, CFH, SDC4, LTBP2, THSD4, CNN2, CLMP, RRAS, PODXL, PDGFC, SLIT2, IGFBP6, ANGPT1, CRIM1, AKR1C3, RAB27B, EHD2, KRT18, COL5A1, AXL, TGFBI, FBN1",148,2811,18224,2.321651427,3.74E-07,6.23E-08,5.43E-08
MES,GOTERM_CC_DIRECT,GO:0005886~plasma membrane,65,43.62416107,1.29E-08,"ITGB1, NRP1, CSF1, SERPINE1, FHL1, ANTXR2, RGS4, GLIPR1, GPR176, CDH2, BASP1, PLAU, RAC2, EPHB2, TGM2, ABCC3, GPR39, SLC38A1, WNT5B, ITGA2, WNT5A, RRAS2, LIFR, OSMR, F3, TGFBR2, ARL4C, SLC9A7, MAP1B, KCNMA1, ADAM12, CDH13, ITGA5, PLPP3, EPHA2, PTGFR, COL13A1, SDC4, ARHGEF28, NTM, NTN4, LPAR1, TFPI, EGFR, HRH1, CLMP, RRAS, PODXL, PDGFC, TSPAN5, SLIT2, FLNC, GBP1, SLC14A1, FZD2, ANGPT1, SMURF2, SMAGP, ATP8B1, CAV1, CRIM1, EHD2, AXL, ITGA11, TGFBI",148,4121,18224,1.94219456,2.52E-06,3.59E-07,3.13E-07
MES,KEGG_PATHWAY,hsa04510:Focal adhesion,15,10.06711409,1.32E-08,"ITGB1, ITGA2, CAV1, VEGFC, EGFR, MYLK, COL1A1, COL5A1, COL6A2, PDGFC, COL6A1, ITGA11, RAC2, FLNC, ITGA5",71,206,6879,7.054902229,1.78E-06,1.80E-06,1.66E-06
MES,GOTERM_BP_DIRECT,GO:0030335~positive regulation of cell migration,13,8.724832215,6.16E-08,"WNT5B, CSF1, RRAS2, F3, CYR61, EGFR, MYLK, COL1A1, PODXL, PLAU, PDGFC, CDH13, ITGA5",145,184,16792,8.182008996,8.95E-05,2.98E-05,2.91E-05
MES,GOTERM_CC_DIRECT,GO:0009986~cell surface,20,13.42281879,7.76E-08,"ITGB1, NRP1, WNT5B, SDC4, ITGA2, TPBG, WNT5A, LPAR1, TFPI, CLU, F3, EGFR, CLMP, SRPX2, AXL, PLAU, PDGFC, SLIT2, ITGA5, EPHA2",148,542,18224,4.543731924,1.51E-05,1.89E-06,1.65E-06
MES,KEGG_PATHWAY,hsa04151:PI3K-Akt signaling pathway,17,11.40939597,2.35E-07,"ITGB1, CSF1, ANGPT1, ITGA2, LPAR1, VEGFC, OSMR, EGFR, FGF5, COL1A1, COL5A1, COL6A2, PDGFC, COL6A1, ITGA11, ITGA5, EPHA2",71,345,6879,4.774157991,3.18E-05,1.60E-05,1.48E-05
MES,GOTERM_BP_DIRECT,GO:0042060~wound healing,9,6.040268456,4.14E-07,"CNN2, SDC4, WNT5B, LOX, TPM1, WNT5A, NRG1, EGFR, TGFBR2",145,80,16792,13.02827586,6.01E-04,1.44E-04,1.41E-04
MES,GOTERM_BP_DIRECT,GO:0001525~angiogenesis,13,8.724832215,4.97E-07,"NRP1, ANGPT1, CAV1, SERPINE1, TNFAIP2, VEGFC, ESM1, SRPX2, CCL2, COL8A1, TGFBI, ITGA5, EPHB2",145,223,16792,6.751074687,7.21E-04,1.44E-04,1.41E-04
MES,KEGG_PATHWAY,hsa05205:Proteoglycans in cancer,13,8.724832215,6.35E-07,"ITGB1, FZD2, WNT5B, SDC4, ITGA2, CAV1, WNT5A, RRAS2, EGFR, RRAS, PLAU, FLNC, ITGA5",71,200,6879,6.297676056,8.57E-05,2.88E-05,2.67E-05
MES,GOTERM_BP_DIRECT,GO:0002040~sprouting angiogenesis,6,4.026845638,2.00E-06,"NRP1, CCBE1, ESM1, ANGPT1, CDH13, LOXL2",145,25,16792,27.79365517,0.002902019,4.84E-04,4.72E-04
MES,KEGG_PATHWAY,hsa04512:ECM-receptor interaction,9,6.040268456,2.36E-06,"ITGB1, COL1A1, SDC4, COL5A1, ITGA2, COL6A2, ITGA11, COL6A1, ITGA5",71,87,6879,10.02282661,3.18E-04,8.01E-05,7.42E-05
MES,GOTERM_CC_DIRECT,GO:0005788~endoplasmic reticulum lumen,11,7.382550336,3.63E-06,"COL1A1, WNT5B, COL5A1, COL13A1, COL6A2, WNT5A, PDGFC, COL12A1, COL6A1, COL8A1, GAS6",148,192,18224,7.054617117,7.08E-04,7.87E-05,6.86E-05
MES,GOTERM_BP_DIRECT,GO:0033627~cell adhesion mediated by integrin,5,3.355704698,6.58E-06,"ITGB1, ITGA2, ITGA11, ITGA5, FBN1",145,15,16792,38.60229885,0.0095069,0.001363681,0.001329848
MES,GOTERM_MF_DIRECT,GO:0008201~heparin binding,10,6.711409396,7.93E-06,"NRP1, CCDC80, CFH, COL5A1, COL13A1, CCL2, LTBP2, SLIT2, CYR61, FBN1",142,160,16881,7.430017606,0.002566527,0.001284908,0.001249216
MES,GOTERM_CC_DIRECT,GO:0005581~collagen trimer,8,5.369127517,9.51E-06,"COL1A1, CCBE1, COL5A1, COL13A1, LOX, COL6A2, COL12A1, COL6A1",148,92,18224,10.70740306,0.001853496,1.86E-04,1.62E-04
MES,GOTERM_BP_DIRECT,GO:0031589~cell-substrate adhesion,5,3.355704698,1.13E-05,"ITGB1, ANGPT1, ITGA2, ITGA5, GAS6",145,17,16792,34.06085193,0.016300259,0.002052895,0.002001961
MES,GOTERM_BP_DIRECT,GO:0030574~collagen catabolic process,7,4.697986577,1.78E-05,"COL1A1, COL5A1, COL13A1, COL6A2, COL12A1, COL6A1, COL8A1",145,64,16792,12.66637931,0.025572594,0.002876354,0.00280499
MES,KEGG_PATHWAY,hsa04015:Rap1 signaling pathway,11,7.382550336,4.54E-05,"ITGB1, FGF5, CSF1, ANGPT1, RRAS, PDGFC, RAC2, LPAR1, VEGFC, EGFR, EPHA2",71,210,6879,5.075050302,0.00611115,0.001029194,9.54E-04
MES,KEGG_PATHWAY,hsa04810:Regulation of actin cytoskeleton,11,7.382550336,4.54E-05,"ITGB1, FGF5, RRAS, ITGA2, ITGA11, PDGFC, RAC2, RRAS2, ITGA5, EGFR, MYLK",71,210,6879,5.075050302,0.00611115,0.001029194,9.54E-04
MES,GOTERM_BP_DIRECT,GO:0008284~positive regulation of cell proliferation,15,10.06711409,4.85E-05,"ITGB1, PTGFR, CSF1, AKR1C3, VEGFC, LIFR, NRG1, OSMR, EGFR, TGFBR2, FGF5, ESM1, PDGFC, RAC2, SOX9",145,466,16792,3.727689803,0.067941741,0.00703098,0.006856538
MES,GOTERM_BP_DIRECT,GO:0045766~positive regulation of angiogenesis,8,5.369127517,5.97E-05,"CCBE1, DDAH1, RRAS, WNT5A, SERPINE1, VEGFC, F3, TGFBR2",145,115,16792,8.056131934,0.082986316,0.007870058,0.007674798
MES,GOTERM_BP_DIRECT,GO:0051897~positive regulation of protein kinase B signaling,7,4.697986577,8.41E-05,"ANGPT1, AXL, AKR1C3, NRG1, GAS6, F3, EGFR",145,84,16792,9.650574713,0.114896066,0.010163418,0.009911259
MES,GOTERM_BP_DIRECT,GO:0016477~cell migration,9,6.040268456,1.19E-04,"ITGB1, SDC4, CDH2, COL5A1, PODXL, FSCN1, ADAMTS12, GAS6, EPHA2",145,172,16792,6.059663192,0.158390209,0.012307844,0.01200248
MES,GOTERM_BP_DIRECT,GO:0001666~response to hypoxia,9,6.040268456,1.19E-04,"PLAU, CITED2, ITGA2, CAV1, KCNMA1, VEGFC, CCL2, LOXL2, TGFBR2",145,172,16792,6.059663192,0.158390209,0.012307844,0.01200248
MES,GOTERM_CC_DIRECT,GO:0016324~apical plasma membrane,11,7.382550336,1.28E-04,"CDH2, ATP8B1, PODXL, CAV1, KCNMA1, RAB27B, LMO7, NRG1, AMOTL2, OSMR, EGFR",148,291,18224,4.654592737,0.024666319,0.002270366,0.001979294
MES,GOTERM_BP_DIRECT,GO:0043491~protein kinase B signaling,5,3.355704698,1.75E-04,"AXL, CCL2, SOX9, GAS6, EPHA2",145,33,16792,17.54649948,0.224322069,0.016921382,0.016501555
MES,GOTERM_BP_DIRECT,GO:0001649~osteoblast differentiation,7,4.697986577,2.73E-04,"COL1A1, VCAN, ITGA11, COL6A1, RRAS2, CYR61, EPHA2",145,104,16792,7.79469496,0.327047117,0.024734575,0.024120898
MES,GOTERM_BP_DIRECT,GO:0010811~positive regulation of cell-substrate adhesion,5,3.355704698,3.05E-04,"CCDC80, COL8A1, ITGA5, EDIL3, CYR61",145,38,16792,15.23774955,0.358069553,0.025215587,0.024589976
MES,GOTERM_BP_DIRECT,GO:0001938~positive regulation of endothelial cell proliferation,6,4.026845638,3.13E-04,"NRP1, WNT5A, VEGFC, CDH13, CCL2, F3",145,69,16792,10.07016492,0.365085172,0.025215587,0.024589976
MES,GOTERM_BP_DIRECT,GO:0030199~collagen fibril organization,5,3.355704698,3.38E-04,"COL1A1, COL5A1, LOX, COL12A1, LOXL2",145,39,16792,14.84703802,0.387786858,0.025802843,0.025162662
MES,GOTERM_CC_DIRECT,GO:0009897~external side of plasma membrane,9,6.040268456,3.39E-04,"ITGB1, ALCAM, HEG1, ITGA2, CDH13, NRG1, ITGA5, ANTXR2, TGFBR2",148,213,18224,5.202893034,0.064011441,0.005511734,0.004805101
MES,GOTERM_BP_DIRECT,GO:0071260~cellular response to mechanical stimulus,6,4.026845638,3.57E-04,"CNN2, COL1A1, ITGA2, IRF1, SOX9, EGFR",145,71,16792,9.7864983,0.404953982,0.025933315,0.025289897
MES,GOTERM_BP_DIRECT,GO:0050729~positive regulation of inflammatory response,6,4.026845638,4.07E-04,"ITGA2, WNT5A, SERPINE1, CCL2, EGFR, TGM2",145,73,16792,9.518375059,0.446082939,0.0281054,0.027408091
MES,KEGG_PATHWAY,hsa04014:Ras signaling pathway,10,6.711409396,4.32E-04,"FGF5, CSF1, ANGPT1, RRAS, PDGFC, RAC2, VEGFC, RRAS2, EGFR, EPHA2",71,226,6879,4.287049732,0.056615518,0.008385771,0.00776917
MES,GOTERM_CC_DIRECT,GO:0005604~basement membrane,6,4.026845638,4.45E-04,"CCDC80, COL5A1, NTN4, TGFBI, LOXL2, FBN1",148,79,18224,9.35203558,0.083136348,0.006675169,0.005819378
MES,GOTERM_BP_DIRECT,GO:0045785~positive regulation of cell adhesion,5,3.355704698,4.94E-04,"ANGPT1, ITGA2, TPM1, NRG1, TGM2",145,43,16792,13.4659182,0.511778003,0.032559746,0.031751923
MES,GOTERM_BP_DIRECT,GO:0031290~retinal ganglion cell axon guidance,4,2.684563758,5.41E-04,"NRP1, ALCAM, SLIT2, EPHB2",145,19,16792,24.38039927,0.544303845,0.034138053,0.033291072
MES,GOTERM_BP_DIRECT,GO:0050900~leukocyte migration,7,4.697986577,6.41E-04,"ITGB1, COL1A1, ANGPT1, PODXL, CAV1, ITGA5, GAS6",145,122,16792,6.644657999,0.60566119,0.036698023,0.035787528
MES,GOTERM_MF_DIRECT,GO:0098639~collagen binding involved in cell-matrix adhesion,3,2.013422819,6.81E-04,"ITGB1, ITGA2, ITGA11",142,5,16881,71.32816901,0.19816476,0.051059606,0.049641283
MES,GOTERM_BP_DIRECT,GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation,6,4.026845638,6.95E-04,"NRP1, ANGPT1, VEGFC, NRG1, ITGA5, PLPP3",145,82,16792,8.473675357,0.635472137,0.036698023,0.035787528
MES,GOTERM_BP_DIRECT,GO:0031100~organ regeneration,5,3.355704698,6.95E-04,"NNMT, AXL, CCL2, GAS6, TGFBR2",145,47,16792,12.31988261,0.635507156,0.036698023,0.035787528
MES,GOTERM_BP_DIRECT,GO:0071230~cellular response to amino acid stimulus,5,3.355704698,6.95E-04,"COL1A1, ZEB1, PDGFC, COL6A1, EGFR",145,47,16792,12.31988261,0.635507156,0.036698023,0.035787528
MES,GOTERM_BP_DIRECT,GO:0032534~regulation of microvillus assembly,3,2.013422819,7.18E-04,"ATP8B1, PODXL, FSCN1",145,5,16792,69.48413793,0.647600644,0.036698023,0.035787528
MES,GOTERM_BP_DIRECT,GO:0030879~mammary gland development,4,2.684563758,7.33E-04,"ITGA2, CAV1, NRG1, SOX9",145,21,16792,22.05845649,0.655398591,0.036698023,0.035787528
MES,GOTERM_MF_DIRECT,GO:0005102~receptor binding,11,7.382550336,7.71E-04,"SRPX2, ALCAM, WNT5B, SMAGP, CAV1, SERPINE1, CCL2, NRG1, IGFBP6, EPHB2, GAS6",142,353,16881,3.704484699,0.221078366,0.051059606,0.049641283
MES,GOTERM_MF_DIRECT,GO:0003924~GTPase activity,9,6.040268456,7.88E-04,"ARL4C, RRAS, RAC2, RRAS2, RAB27B, RND3, GBP1, GBP3, TGM2",142,234,16881,4.572318527,0.225392371,0.051059606,0.049641283
MES,GOTERM_BP_DIRECT,GO:0071560~cellular response to transforming growth factor beta stimulus,5,3.355704698,8.15E-04,"COL1A1, CAV1, WNT5A, SOX9, FBN1",145,49,16792,11.81703026,0.693690362,0.039395412,0.038417993
MES,GOTERM_BP_DIRECT,GO:0090103~cochlea morphogenesis,4,2.684563758,8.44E-04,"ZEB1, FZD2, WNT5A, SOX9",145,22,16792,21.05579937,0.706516449,0.039502334,0.038522262
MES,GOTERM_BP_DIRECT,GO:0007596~blood coagulation,8,5.369127517,0.001053705,"COL1A1, EHD2, PLAU, ITGA2, IRF1, PDGFC, TFPI, F3",145,184,16792,5.035082459,0.783634642,0.047092494,0.045924107
MES,GOTERM_BP_DIRECT,GO:0006929~substrate-dependent cell migration,3,2.013422819,0.001071022,"ITGA2, ITGA11, VEGFC",145,6,16792,57.90344828,0.789012566,0.047092494,0.045924107
MES,GOTERM_BP_DIRECT,GO:0009887~organ morphogenesis,6,4.026845638,0.001169494,"NRP1, ITGA2, FHL1, PDGFC, VEGFC, CCL2",145,92,16792,7.552623688,0.81715191,0.048565954,0.047361009
MES,GOTERM_BP_DIRECT,GO:0001501~skeletal system development,7,4.697986577,0.001171474,"EXT1, COL1A1, VCAN, COL12A1, SOX9, EPHA2, FBN1",145,137,16792,5.9171407,0.817677278,0.048565954,0.047361009
MES,GOTERM_BP_DIRECT,GO:0008283~cell proliferation,11,7.382550336,0.001238972,"FGF5, ZEB1, CSF1, CITED2, ITGA2, FSCN1, NRG1, TGFBI, GAS6, CYR61, EGFR",145,366,16792,3.480535142,0.834718031,0.049937445,0.048698473
MES,GOTERM_CC_DIRECT,GO:0008305~integrin complex,4,2.684563758,0.001304959,"ITGB1, ITGA2, ITGA11, ITGA5",148,27,18224,18.24224224,0.224799125,0.018176208,0.015845925
MES,GOTERM_BP_DIRECT,GO:0001570~vasculogenesis,5,3.355704698,0.001348075,"CITED2, HEG1, CAV1, EPHA2, TGFBR2",145,56,16792,10.33990148,0.858961893,0.051547674,0.050268752
MES,GOTERM_BP_DIRECT,GO:0030336~negative regulation of cell migration,6,4.026845638,0.001349974,"CNN2, RRAS, CITED2, TPM1, SERPINE1, SLIT2",145,95,16792,7.314119782,0.859350719,0.051547674,0.050268752
MES,GOTERM_CC_DIRECT,GO:0045121~membrane raft,8,5.369127517,0.001428946,"ITGB1, SDC4, ANGPT1, SMURF2, PODXL, CAV1, EGFR, TGFBR2",148,206,18224,4.781946996,0.243341848,0.018576296,0.016194719
MES,GOTERM_MF_DIRECT,GO:0019838~growth factor binding,4,2.684563758,0.001440555,"NRP1, LTBP2, LIFR, OSMR",142,27,16881,17.61189358,0.373167668,0.077789947,0.075629115
MES,GOTERM_BP_DIRECT,GO:0035987~endodermal cell differentiation,4,2.684563758,0.001553502,"COL12A1, COL6A1, COL8A1, ITGA5",145,27,16792,17.15657727,0.895381869,0.05779823,0.056364229
MES,GOTERM_BP_DIRECT,GO:0048661~positive regulation of smooth muscle cell proliferation,5,3.355704698,0.001743103,"ITGA2, CDH13, EGFR, TGFBR2, TGM2",145,60,16792,9.650574713,0.920594993,0.063231058,0.061662265
MES,KEGG_PATHWAY,hsa04360:Axon guidance,7,4.697986577,0.001755875,"ITGB1, NRP1, RAC2, NTN4, SLIT2, EPHB2, EPHA2",71,127,6879,5.340246202,0.211207152,0.029079338,0.026941151
MES,GOTERM_CC_DIRECT,GO:0005901~caveola,5,3.355704698,0.001878689,"EHD2, CAV1, KCNMA1, CDH13, TGFBR2",148,65,18224,9.471933472,0.306974752,0.021869162,0.019065423
MES,GOTERM_CC_DIRECT,GO:0030027~lamellipodium,7,4.697986577,0.001906542,"ITGB1, CDH2, PODXL, FSCN1, RAC2, EPHA2, MYLK",148,160,18224,5.387162162,0.310735782,0.021869162,0.019065423
MES,KEGG_PATHWAY,hsa04974:Protein digestion and absorption,6,4.026845638,0.001924368,"COL1A1, COL5A1, COL13A1, COL6A2, COL12A1, COL6A1",71,88,6879,6.605953905,0.228979223,0.029079338,0.026941151
MES,GOTERM_CC_DIRECT,GO:0005887~integral component of plasma membrane,23,15.43624161,0.002193403,"ABCC3, SLC14A1, PTGFR, GPR39, SLC38A1, SDC4, SMAGP, ATP8B1, CAV1, TPBG, LPAR1, LIFR, NRG1, TGFBR2, HRH1, GPR176, ALCAM, PODXL, AXL, TSPAN5, EPHB2, PLPP3, EPHA2",148,1415,18224,2.001489829,0.348308139,0.023761871,0.020715477
MES,GOTERM_MF_DIRECT,GO:0003779~actin binding,9,6.040268456,0.002349022,"CNN2, ITGB1, TPM1, KCNMA1, FSCN1, AFAP1, MICAL2, GBP1, MYLK",142,278,16881,3.848642213,0.533257933,0.092970139,0.090387635
MES,GOTERM_MF_DIRECT,GO:0005201~extracellular matrix structural constituent,5,3.355704698,0.002378653,"COL1A1, VCAN, COL5A1, PXDN, FBN1",142,67,16881,8.871662813,0.53772787,0.092970139,0.090387635
MES,GOTERM_BP_DIRECT,GO:0007411~axon guidance,7,4.697986577,0.00249863,"EXT1, NRP1, BDNF, WNT5A, NTN4, SLIT2, EPHB2",145,159,16792,5.098416829,0.973551359,0.087314302,0.085147992
MES,GOTERM_BP_DIRECT,GO:0043589~skin morphogenesis,3,2.013422819,0.002527361,"COL1A1, ERRFI1, ITGA2",145,9,16792,38.60229885,0.974634701,0.087314302,0.085147992
MES,GOTERM_MF_DIRECT,GO:0004222~metalloendopeptidase activity,6,4.026845638,0.002582504,"ADAM19, PAPPA, ADAM12, ADAMTS12, THSD4, ADAMTS6",142,113,16881,6.312227346,0.567344527,0.092970139,0.090387635
MES,GOTERM_CC_DIRECT,GO:0005911~cell-cell junction,7,4.697986577,0.002738924,"CNN2, CDH2, COL13A1, HEG1, KRT8, FSCN1, ITGA5",148,172,18224,5.011313639,0.414226952,0.02717591,0.023691819
MES,GOTERM_CC_DIRECT,GO:0001527~microfibril,3,2.013422819,0.002787273,"LTBP1, THSD4, FBN1",148,10,18224,36.94054054,0.419738886,0.02717591,0.023691819
MES,GOTERM_BP_DIRECT,GO:0071364~cellular response to epidermal growth factor stimulus,4,2.684563758,0.002791022,"COL1A1, ERRFI1, SOX9, EGFR",145,33,16792,14.03719958,0.982720415,0.093245789,0.090932317
MES,GOTERM_BP_DIRECT,GO:0090090~negative regulation of canonical Wnt signaling pathway,7,4.697986577,0.002827577,"WNT5B, CDH2, CAV1, WNT5A, IGFBP6, SOX9, DKK3",145,163,16792,4.973302306,0.983616127,0.093245789,0.090932317
MES,GOTERM_BP_DIRECT,GO:0071300~cellular response to retinoic acid,5,3.355704698,0.003068376,"COL1A1, WNT5B, WNT5A, CCL2, SOX9",145,70,16792,8.271921182,0.988462251,0.098938077,0.096483377
MES,GOTERM_MF_DIRECT,GO:0048407~platelet-derived growth factor binding,3,2.013422819,0.003626413,"COL1A1, COL5A1, COL6A1",142,11,16881,32.42189501,0.691826866,0.117495793,0.114232021
MES,GOTERM_BP_DIRECT,GO:0050927~positive regulation of positive chemotaxis,3,2.013422819,0.003818044,"ITGA2, CDH13, F3",145,11,16792,31.58369906,0.996129648,0.114799043,0.111950824
MES,GOTERM_BP_DIRECT,GO:0030857~negative regulation of epithelial cell differentiation,3,2.013422819,0.003818044,"ZEB1, CAV1, SOX9",145,11,16792,31.58369906,0.996129648,0.114799043,0.111950824
MES,GOTERM_BP_DIRECT,"GO:0045892~negative regulation of transcription, DNA-templated",12,8.053691275,0.003841393,"ZEB1, SMURF2, CITED2, ATP8B1, BASP1, IRF1, WNT5A, NRG1, SOX9, GAS6, LOXL2, DKK3",145,499,16792,2.784935388,0.996259153,0.114799043,0.111950824
MES,GOTERM_BP_DIRECT,GO:0007162~negative regulation of cell adhesion,4,2.684563758,0.003876742,"ANGPT1, PODXL, CDH13, TGFBI",145,37,16792,12.51966449,0.996447023,0.114799043,0.111950824
MES,GOTERM_BP_DIRECT,GO:0030324~lung development,5,3.355704698,0.004127245,"CCBE1, LOX, HEG1, WNT5A, EGFR",145,76,16792,7.618874773,0.997534005,0.119006785,0.11605417
MES,GOTERM_BP_DIRECT,GO:0001568~blood vessel development,4,2.684563758,0.004182871,"COL1A1, COL5A1, PLPP3, TGFBR2",145,38,16792,12.19019964,0.997726118,0.119006785,0.11605417
MES,GOTERM_CC_DIRECT,GO:0032587~ruffle membrane,5,3.355704698,0.004368069,"ITGB1, DDX58, TPM1, ITGA5, EPHA2",148,82,18224,7.508239947,0.574137673,0.040141658,0.034995292
MES,GOTERM_CC_DIRECT,GO:0048471~perinuclear region of cytoplasm,13,8.724832215,0.004528802,"ITGB1, CSF1, BDNF, ITGA2, CAV1, CLU, EGFR, EHD2, KRT18, STC2, CCL2, CDH13, GBP3",148,621,18224,2.577708143,0.587336285,0.040141658,0.034995292
MES,GOTERM_BP_DIRECT,GO:0048846~axon extension involved in axon guidance,3,2.013422819,0.004555975,"NRP1, ALCAM, SLIT2",145,12,16792,28.95172414,0.998680353,0.124730565,0.12163594
MES,GOTERM_BP_DIRECT,GO:0007171~activation of transmembrane receptor protein tyrosine kinase activity,3,2.013422819,0.004555975,"ANGPT1, PDGFC, NRG1",145,12,16792,28.95172414,0.998680353,0.124730565,0.12163594
MES,KEGG_PATHWAY,hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC),5,3.355704698,0.004653592,"ITGB1, CDH2, ITGA2, ITGA11, ITGA5",71,67,6879,7.230397309,0.467249037,0.063288847,0.058635255
MES,GOTERM_CC_DIRECT,GO:0005913~cell-cell adherens junction,9,6.040268456,0.004744234,"CNN2, ITGB1, KRT18, CDH2, SMAGP, FSCN1, LMO7, EGFR, EPHA2",148,323,18224,3.431009957,0.604390283,0.040222854,0.035066078
MES,GOTERM_BP_DIRECT,GO:0001558~regulation of cell growth,5,3.355704698,0.00495584,"ESM1, CRIM1, SPOCK1, IGFBP6, CYR61",145,80,16792,7.237931034,0.999263624,0.129033973,0.125832578
MES,GOTERM_BP_DIRECT,GO:0046718~viral entry into host cell,5,3.355704698,0.00495584,"ITGB1, AXL, ITGA2, ITGA5, GAS6",145,80,16792,7.237931034,0.999263624,0.129033973,0.125832578
MES,GOTERM_CC_DIRECT,GO:0042383~sarcolemma,5,3.355704698,0.004963747,"ITGB1, COL6A2, COL6A1, KRT8, FLNC",148,85,18224,7.243243243,0.621046153,0.040330442,0.035159872
MES,GOTERM_BP_DIRECT,GO:0007507~heart development,7,4.697986577,0.004979947,"ADAM19, LOX, CITED2, HEG1, MICAL2, TGFBR2, FBN1",145,183,16792,4.429771999,0.999289077,0.129033973,0.125832578
MES,GOTERM_MF_DIRECT,GO:0005525~GTP binding,10,6.711409396,0.004991067,"ARL4C, EHD2, RRAS, RAC2, RRAS2, RAB27B, RND3, GBP1, GBP3, TGM2",142,384,16881,3.095840669,0.80232971,0.139887001,0.136001251
MES,KEGG_PATHWAY,hsa04610:Complement and coagulation cascades,5,3.355704698,0.005169543,"CFH, PLAU, SERPINE1, TFPI, F3",71,69,6879,7.020820576,0.50326493,0.063914352,0.059214767
MES,GOTERM_MF_DIRECT,GO:0004713~protein tyrosine kinase activity,6,4.026845638,0.005181,"FGF5, AXL, NRG1, EPHB2, EGFR, EPHA2",142,133,16881,5.363020227,0.814185723,0.139887001,0.136001251
MES,KEGG_PATHWAY,hsa05200:Pathways in cancer,11,7.382550336,0.006031457,"ITGB1, FGF5, FZD2, WNT5B, ITGA2, WNT5A, RAC2, LPAR1, VEGFC, EGFR, TGFBR2",71,393,6879,2.71185894,0.558117908,0.068356515,0.063330301
MES,GOTERM_BP_DIRECT,GO:0070208~protein heterotrimerization,3,2.013422819,0.006211581,"COL1A1, COL6A2, COL6A1",145,14,16792,24.81576355,0.999882297,0.158122888,0.154199784
MES,GOTERM_BP_DIRECT,GO:0043277~apoptotic cell clearance,3,2.013422819,0.007127123,"AXL, GAS6, TGM2",145,15,16792,23.16137931,0.999969127,0.1731815,0.168884784
MES,GOTERM_BP_DIRECT,GO:0002042~cell migration involved in sprouting angiogenesis,3,2.013422819,0.007127123,"ITGB1, NRP1, SLIT2",145,15,16792,23.16137931,0.999969127,0.1731815,0.168884784
MES,GOTERM_BP_DIRECT,GO:0010595~positive regulation of endothelial cell migration,4,2.684563758,0.007161192,"NRP1, CCBE1, ANGPT1, WNT5A",145,46,16792,10.07016492,0.999970628,0.1731815,0.168884784
MES,GOTERM_BP_DIRECT,GO:0007160~cell-matrix adhesion,5,3.355704698,0.007498326,"ITGB1, COL13A1, ITGA2, ITGA11, ADAMTS12",145,90,16792,6.433716475,0.999982062,0.177913204,0.173499093
MES,GOTERM_BP_DIRECT,GO:0045860~positive regulation of protein kinase activity,4,2.684563758,0.00760208,"SDC4, CSF1, GAS6, CYR61",145,47,16792,9.85590609,0.999984588,0.177913204,0.173499093
MES,GOTERM_CC_DIRECT,GO:0005796~Golgi lumen,5,3.355704698,0.00760934,"VCAN, SDC4, WNT5B, WNT5A, GAS6",148,96,18224,6.413288288,0.77451362,0.059352851,0.051743511
MES,KEGG_PATHWAY,hsa05410:Hypertrophic cardiomyopathy (HCM),5,3.355704698,0.007966615,"ITGB1, ITGA2, TPM1, ITGA11, ITGA5",71,78,6879,6.210725894,0.660336533,0.083343051,0.077214885
MES,GOTERM_BP_DIRECT,GO:0007179~transforming growth factor beta receptor signaling pathway,5,3.355704698,0.008092898,"ITGB1, CITED2, CCL2, LTBP2, TGFBR2",145,92,16792,6.293853073,0.999992486,0.183636707,0.179080593
MES,GOTERM_BP_DIRECT,GO:0061036~positive regulation of cartilage development,3,2.013422819,0.008099758,"WNT5A, SOX9, CYR61",145,16,16792,21.7137931,0.999992561,0.183636707,0.179080593
MES,GOTERM_MF_DIRECT,GO:0004867~serine-type endopeptidase inhibitor activity,5,3.355704698,0.008875988,"SERPINE1, CRIM1, SPOCK1, SERPINB7, TFPI",142,97,16881,6.127849572,0.944349203,0.221216922,0.215072007
MES,GOTERM_BP_DIRECT,GO:0007157~heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,4,2.684563758,0.009019534,"ALCAM, CDH2, SMAGP, ITGA5",145,50,16792,9.264551724,0.999998066,0.200687676,0.19570852
MES,GOTERM_BP_DIRECT,GO:2000811~negative regulation of anoikis,3,2.013422819,0.009128454,"ITGB1, CAV1, ITGA5",145,17,16792,20.43651116,0.999998351,0.200687676,0.19570852
MES,GOTERM_CC_DIRECT,GO:0001725~stress fiber,4,2.684563758,0.009445568,"CNN2, TPM1, FSCN1, MYLK",148,54,18224,9.121121121,0.842863388,0.070340749,0.061322704
MES,GOTERM_MF_DIRECT,GO:0005520~insulin-like growth factor binding,3,2.013422819,0.009709593,"ESM1, CRIM1, CYR61",142,18,16881,19.81338028,0.957628545,0.224707718,0.218465837
MES,GOTERM_CC_DIRECT,GO:0031093~platelet alpha granule lumen,4,2.684563758,0.009932403,"SERPINE1, VEGFC, GAS6, CLU",148,55,18224,8.955282555,0.857227287,0.070340749,0.061322704
MES,GOTERM_CC_DIRECT,GO:0043034~costamere,3,2.013422819,0.01010021,"SDC4, KRT8, FLNC",148,19,18224,19.44238976,0.861869286,0.070340749,0.061322704
MES,GOTERM_BP_DIRECT,GO:0035904~aorta development,3,2.013422819,0.010212191,"LOX, LTBP1, ADAMTS6",145,18,16792,19.30114943,0.999999663,0.21901996,0.213585971
MES,GOTERM_BP_DIRECT,GO:0018108~peptidyl-tyrosine phosphorylation,6,4.026845638,0.010281196,"FGF5, AXL, NRG1, EPHB2, EGFR, EPHA2",145,153,16792,4.541446924,0.999999696,0.21901996,0.213585971
MES,KEGG_PATHWAY,hsa05414:Dilated cardiomyopathy,5,3.355704698,0.010297552,"ITGB1, ITGA2, TPM1, ITGA11, ITGA5",71,84,6879,5.767102616,0.752755292,0.100033362,0.092677968
MES,GOTERM_BP_DIRECT,GO:0007229~integrin-mediated signaling pathway,5,3.355704698,0.010415146,"ITGB1, ITGA2, ITGA11, ADAM12, ITGA5",145,99,16792,5.848833159,0.99999975,0.21901996,0.213585971
MES,GOTERM_BP_DIRECT,GO:0048146~positive regulation of fibroblast proliferation,4,2.684563758,0.011134793,"WNT5A, PDGFC, GAS6, EGFR",145,54,16792,8.578288633,0.999999913,0.227866108,0.222212641
MES,GOTERM_BP_DIRECT,GO:0016337~single organismal cell-cell adhesion,5,3.355704698,0.011149892,"SRPX2, COL13A1, LMO7, SOX9, EGFR",145,101,16792,5.733014681,0.999999915,0.227866108,0.222212641
MES,GOTERM_MF_DIRECT,GO:0008083~growth factor activity,6,4.026845638,0.011633188,"FGF5, CSF1, BDNF, PDGFC, VEGFC, NRG1",142,162,16881,4.402973396,0.97743258,0.251276856,0.244296943
MES,GOTERM_BP_DIRECT,GO:0017015~regulation of transforming growth factor beta receptor signaling pathway,3,2.013422819,0.012540777,"ZEB1, SMURF2, DKK3",145,20,16792,17.37103448,0.999999989,0.252731502,0.246461113
MES,GOTERM_MF_DIRECT,GO:0005518~collagen binding,4,2.684563758,0.0137995,"CCBE1, ITGA2, ITGA11, TGFBI",142,60,16881,7.925352113,0.988915125,0.279439869,0.271677651
MES,KEGG_PATHWAY,hsa04010:MAPK signaling pathway,8,5.369127517,0.013951887,"FGF5, RRAS, BDNF, RAC2, RRAS2, FLNC, EGFR, TGFBR2",71,253,6879,3.063630797,0.849947116,0.12649711,0.117195852
MES,GOTERM_BP_DIRECT,GO:0001954~positive regulation of cell-matrix adhesion,3,2.013422819,0.015077624,"CSF1, VEGFC, CDH13",145,22,16792,15.79184953,1,0.299693592,0.292258052
MES,GOTERM_BP_DIRECT,GO:0001947~heart looping,4,2.684563758,0.015471857,"CITED2, WNT5A, MICAL2, TGFBR2",145,61,16792,7.593894856,1,0.303373846,0.295846997
MES,GOTERM_CC_DIRECT,GO:0034681~integrin alpha11-beta1 complex,2,1.342281879,0.016067947,"ITGB1, ITGA11",148,2,18224,123.1351351,0.957518855,0.108043089,0.094191411
MES,GOTERM_BP_DIRECT,GO:0051965~positive regulation of synapse assembly,4,2.684563758,0.016158498,"SRPX2, BDNF, TPBG, EPHB2",145,62,16792,7.471412681,1,0.305927966,0.298337748
MES,GOTERM_BP_DIRECT,GO:0071222~cellular response to lipopolysaccharide,5,3.355704698,0.016260351,"AXL, WNT5A, SERPINE1, CCL2, TFPI",145,113,16792,5.124198962,1,0.305927966,0.298337748
MES,GOTERM_BP_DIRECT,GO:0032967~positive regulation of collagen biosynthetic process,3,2.013422819,0.016421733,"ITGA2, CCL2, SERPINB7",145,23,16792,15.10524738,1,0.305927966,0.298337748
MES,GOTERM_MF_DIRECT,GO:0038064~collagen receptor activity,2,1.342281879,0.016635896,"ITGA2, ITGA11",142,2,16881,118.8802817,0.99564037,0.30700794,0.298479941
MES,GOTERM_BP_DIRECT,GO:0043066~negative regulation of apoptotic process,10,6.711409396,0.016648092,"PTGFR, KRT18, ANGPT1, CITED2, WNT5A, SOX9, GAS6, CYR61, EGFR, TGM2",145,455,16792,2.545206518,1,0.305927966,0.298337748
MES,GOTERM_MF_DIRECT,GO:0005509~calcium ion binding,13,8.724832215,0.017055997,"CCBE1, HEG1, LTBP2, LTBP1, EHD2, VCAN, CDH2, SPOCK1, CDH13, SLIT2, GAS6, EDIL3, FBN1",142,717,16881,2.155430491,0.99620402,0.30700794,0.298479941
MES,GOTERM_BP_DIRECT,GO:0038065~collagen-activated signaling pathway,2,1.342281879,0.017077991,"ITGA2, ITGA11",145,2,16792,115.8068966,1,0.305927966,0.298337748
MES,GOTERM_BP_DIRECT,GO:0030825~positive regulation of cGMP metabolic process,2,1.342281879,0.017077991,"FZD2, WNT5A",145,2,16792,115.8068966,1,0.305927966,0.298337748
MES,GOTERM_BP_DIRECT,GO:1901492~positive regulation of lymphangiogenesis,2,1.342281879,0.017077991,"CCBE1, VEGFC",145,2,16792,115.8068966,1,0.305927966,0.298337748
MES,GOTERM_BP_DIRECT,GO:0070374~positive regulation of ERK1 and ERK2 cascade,6,4.026845638,0.017482555,"NRP1, ANGPT1, PDGFC, CCL2, GAS6, EGFR",145,175,16792,3.970522167,1,0.309355939,0.301680671
MES,GOTERM_BP_DIRECT,GO:0048870~cell motility,3,2.013422819,0.017815039,"SRPX2, FSCN1, EPHA2",145,24,16792,14.47586207,1,0.311441231,0.303714226
MES,GOTERM_BP_DIRECT,GO:0014068~positive regulation of phosphatidylinositol 3-kinase signaling,4,2.684563758,0.018320003,"ANGPT1, PDGFC, NRG1, SOX9",145,65,16792,7.126578249,1,0.316456246,0.308604816
MES,GOTERM_BP_DIRECT,GO:0070372~regulation of ERK1 and ERK2 cascade,3,2.013422819,0.019256612,"RRAS, CYR61, EPHA2",145,25,16792,13.89682759,1,0.328122682,0.319981802
MES,GOTERM_BP_DIRECT,GO:0007264~small GTPase mediated signal transduction,7,4.697986577,0.019447657,"ARL4C, RRAS, RAC2, RRAS2, RAB27B, RIN2, RND3",145,246,16792,3.295318195,1,0.328122682,0.319981802
MES,GOTERM_CC_DIRECT,GO:0043235~receptor complex,5,3.355704698,0.01957208,"ITGB1, NRP1, LIFR, EGFR, TGFBR2",148,127,18224,4.847839966,0.978813671,0.124024519,0.108123939
MES,GOTERM_CC_DIRECT,GO:0030175~filopodium,4,2.684563758,0.019716718,"ITGB1, ARL4C, PODXL, FSCN1",148,71,18224,6.937190712,0.97941451,0.124024519,0.108123939
MES,GOTERM_MF_DIRECT,GO:0001968~fibronectin binding,3,2.013422819,0.019747431,"ITGB1, CCDC80, SDC4",142,26,16881,13.71695558,0.998438621,0.336745667,0.327391621
MES,GOTERM_BP_DIRECT,GO:0010951~negative regulation of endopeptidase activity,5,3.355704698,0.020367258,"SERPINE1, CRIM1, SPOCK1, SERPINB7, TFPI",145,121,16792,4.785408948,1,0.334464082,0.326165869
MES,GOTERM_BP_DIRECT,GO:0032148~activation of protein kinase B activity,3,2.013422819,0.020745532,"WNT5A, NRG1, GAS6",145,26,16792,13.36233422,1,0.334464082,0.326165869
MES,GOTERM_BP_DIRECT,GO:0050999~regulation of nitric-oxide synthase activity,3,2.013422819,0.020745532,"DDAH1, CAV1, EGFR",145,26,16792,13.36233422,1,0.334464082,0.326165869
MES,GOTERM_BP_DIRECT,GO:0002053~positive regulation of mesenchymal cell proliferation,3,2.013422819,0.020745532,"WNT5A, SOX9, TGFBR2",145,26,16792,13.36233422,1,0.334464082,0.326165869
MES,GOTERM_MF_DIRECT,GO:0001618~virus receptor activity,4,2.684563758,0.020787726,"ITGB1, AXL, ITGA2, ITGA5",142,70,16881,6.793158954,0.998893124,0.336761166,0.327406689
MES,GOTERM_BP_DIRECT,GO:0033138~positive regulation of peptidyl-serine phosphorylation,4,2.684563758,0.02226263,"ANGPT1, CAV1, WNT5A, GAS6",145,70,16792,6.617536946,1,0.354978864,0.346171669
MES,GOTERM_BP_DIRECT,GO:0071347~cellular response to interleukin-1,4,2.684563758,0.023102295,"CCL2, SOX9, ADAMTS12, TFPI",145,71,16792,6.5243322,1,0.364363376,0.355323348
MES,GOTERM_BP_DIRECT,GO:0003281~ventricular septum development,3,2.013422819,0.023861805,"HEG1, LTBP1, CYR61",145,28,16792,12.40788177,1,0.365942397,0.356863192
MES,GOTERM_BP_DIRECT,GO:2000352~negative regulation of endothelial cell apoptotic process,3,2.013422819,0.023861805,"ANGPT1, SERPINE1, GAS6",145,28,16792,12.40788177,1,0.365942397,0.356863192
MES,GOTERM_BP_DIRECT,GO:0048010~vascular endothelial growth factor receptor signaling pathway,4,2.684563758,0.023959013,"NRP1, AXL, VEGFC, CCL2",145,72,16792,6.433716475,1,0.365942397,0.356863192
MES,GOTERM_CC_DIRECT,GO:0034666~integrin alpha2-beta1 complex,2,1.342281879,0.024005495,"ITGB1, ITGA2",148,3,18224,82.09009009,0.991245373,0.146283486,0.127529193
MES,GOTERM_MF_DIRECT,GO:0004720~protein-lysine 6-oxidase activity,2,1.342281879,0.024850503,"LOX, LOXL2",142,3,16881,79.25352113,0.999712214,0.365980131,0.355814016
MES,GOTERM_MF_DIRECT,GO:0004924~oncostatin-M receptor activity,2,1.342281879,0.024850503,"LIFR, OSMR",142,3,16881,79.25352113,0.999712214,0.365980131,0.355814016
MES,GOTERM_BP_DIRECT,GO:0045214~sarcomere organization,3,2.013422819,0.02548738,"ITGB1, TPM1, KRT8",145,29,16792,11.98002378,1,0.366836498,0.35773511
MES,GOTERM_BP_DIRECT,GO:0071549~cellular response to dexamethasone stimulus,3,2.013422819,0.02548738,"ERRFI1, CCL2, EGFR",145,29,16792,11.98002378,1,0.366836498,0.35773511
MES,GOTERM_BP_DIRECT,GO:0035583~sequestering of TGFbeta in extracellular matrix,2,1.342281879,0.025508055,"LTBP1, FBN1",145,3,16792,77.2045977,1,0.366836498,0.35773511
MES,GOTERM_BP_DIRECT,GO:0070168~negative regulation of biomineral tissue development,2,1.342281879,0.025508055,"SOX9, GAS6",145,3,16792,77.2045977,1,0.366836498,0.35773511
MES,GOTERM_BP_DIRECT,GO:2000669~negative regulation of dendritic cell apoptotic process,2,1.342281879,0.025508055,"AXL, GAS6",145,3,16792,77.2045977,1,0.366836498,0.35773511
MES,GOTERM_BP_DIRECT,GO:0010628~positive regulation of gene expression,7,4.697986577,0.02553445,"CNN2, PTGFR, CSF1, DDX58, CITED2, CAV1, GAS6",145,262,16792,3.094077389,1,0.366836498,0.35773511
MES,GOTERM_BP_DIRECT,GO:0043524~negative regulation of neuron apoptotic process,5,3.355704698,0.026974574,"NRP1, ANGPT1, BDNF, AXL, CCL2",145,132,16792,4.386624869,1,0.383726531,0.374206093
MES,GOTERM_MF_DIRECT,GO:0003714~transcription corepressor activity,6,4.026845638,0.027856645,"TLE4, ZEB1, CITED2, BASP1, TCF4, LOXL2",142,203,16881,3.513702907,0.999894167,0.39241535,0.381514923
MES,GOTERM_BP_DIRECT,GO:0045907~positive regulation of vasoconstriction,3,2.013422819,0.030623444,"HRH1, CAV1, EGFR",145,32,16792,10.85689655,1,0.431404051,0.420700712
MES,GOTERM_BP_DIRECT,GO:0010634~positive regulation of epithelial cell migration,3,2.013422819,0.032419084,"ITGA2, SOX9, TGFBR2",145,33,16792,10.52789969,1,0.452308569,0.441086578
MES,GOTERM_MF_DIRECT,GO:0070888~E-box binding,3,2.013422819,0.032644495,"ZEB1, TCF4, ARNTL2",142,34,16881,10.48943662,0.999978625,0.440700687,0.428459001
MES,GOTERM_BP_DIRECT,GO:0050878~regulation of body fluid levels,2,1.342281879,0.033866316,"HEG1, EPHB2",145,4,16792,57.90344828,1,0.459252561,0.447858287
MES,GOTERM_BP_DIRECT,GO:0033631~cell-cell adhesion mediated by integrin,2,1.342281879,0.033866316,"ITGB1, ITGA5",145,4,16792,57.90344828,1,0.459252561,0.447858287
MES,GOTERM_BP_DIRECT,GO:0038165~oncostatin-M-mediated signaling pathway,2,1.342281879,0.033866316,"LIFR, OSMR",145,4,16792,57.90344828,1,0.459252561,0.447858287
MES,GOTERM_BP_DIRECT,GO:0001837~epithelial to mesenchymal transition,3,2.013422819,0.034255148,"WNT5A, SOX9, LOXL2",145,34,16792,10.21825558,1,0.460224258,0.448805875
MES,KEGG_PATHWAY,hsa04520:Adherens junction,4,2.684563758,0.035270466,"RAC2, LMO7, EGFR, TGFBR2",71,71,6879,5.458440786,0.992152117,0.29979896,0.277754919
MES,GOTERM_BP_DIRECT,GO:0048565~digestive tract development,3,2.013422819,0.036130821,"CLMP, PDGFC, TGFBR2",145,35,16792,9.926305419,1,0.476598372,0.46477374
MES,GOTERM_BP_DIRECT,GO:0050918~positive chemotaxis,3,2.013422819,0.036130821,"NRP1, ANGPT1, VEGFC",145,35,16792,9.926305419,1,0.476598372,0.46477374
MES,GOTERM_MF_DIRECT,GO:0004896~cytokine receptor activity,3,2.013422819,0.036266755,"LIFR, OSMR, F3",142,36,16881,9.906690141,0.999993661,0.470017147,0.456961115
MES,GOTERM_CC_DIRECT,GO:0001726~ruffle,4,2.684563758,0.036317696,"ITGB1, PODXL, FSCN1, ITGA5",148,90,18224,5.472672673,0.999263611,0.214604568,0.187091162
MES,GOTERM_BP_DIRECT,GO:0007399~nervous system development,7,4.697986577,0.037387615,"FGF5, BDNF, MAP1B, CRIM1, SPOCK1, NRG1, EPHB2",145,287,16792,2.824558452,1,0.488733595,0.476607883
MES,GOTERM_MF_DIRECT,GO:0004714~transmembrane receptor protein tyrosine kinase activity,3,2.013422819,0.040036029,"AXL, EGFR, EPHA2",142,38,16881,9.385285397,0.999998219,0.492910324,0.47921837
MES,GOTERM_MF_DIRECT,"GO:0016641~oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor",2,1.342281879,0.04107586,"LOX, LOXL2",142,5,16881,47.55211268,0.999998747,0.492910324,0.47921837
MES,GOTERM_BP_DIRECT,GO:0071504~cellular response to heparin,2,1.342281879,0.042153381,"SOX9, SLIT2",145,5,16792,46.32275862,1,0.541279254,0.527849858
MES,GOTERM_BP_DIRECT,"GO:0007598~blood coagulation, extrinsic pathway",2,1.342281879,0.042153381,"TFPI, F3",145,5,16792,46.32275862,1,0.541279254,0.527849858
MES,KEGG_PATHWAY,hsa04611:Platelet activation,5,3.355704698,0.042895059,"ITGB1, COL1A1, COL5A1, ITGA2, MYLK",71,130,6879,3.726435536,0.997311312,0.330699689,0.306383535
MES,KEGG_PATHWAY,hsa05166:HTLV-I infection,7,4.697986577,0.043769076,"NRP1, FZD2, WNT5B, RRAS, WNT5A, RRAS2, TGFBR2",71,254,6879,2.670123101,0.997623292,0.330699689,0.306383535
MES,GOTERM_BP_DIRECT,GO:0009653~anatomical structure morphogenesis,4,2.684563758,0.044638143,"KRT18, FSCN1, CYR61, DKK3",145,92,16792,5.035082459,1,0.568157418,0.554061162
MES,GOTERM_BP_DIRECT,GO:0008584~male gonad development,4,2.684563758,0.047070046,"CITED2, WNT5A, AKR1C3, SOX9",145,94,16792,4.927953045,1,0.593901193,0.579166222
MES,GOTERM_BP_DIRECT,GO:0030182~neuron differentiation,4,2.684563758,0.048310108,"FZD2, WNT5B, WNT5A, EPHA2",145,95,16792,4.876079855,1,0.599070954,0.584207718
MES,GOTERM_MF_DIRECT,GO:0043237~laminin-1 binding,2,1.342281879,0.049087729,"NTN4, SLIT2",142,6,16881,39.62676056,0.999999917,0.559342279,0.543804994
MES,GOTERM_BP_DIRECT,GO:0007010~cytoskeleton organization,5,3.355704698,0.049973757,"CNN2, TPM1, CCL2, MICAL2, SOX9",145,161,16792,3.596487471,1,0.599070954,0.584207718
MES,GOTERM_MF_DIRECT,GO:0030971~receptor tyrosine kinase binding,3,2.013422819,0.050064587,"ANGPT1, NRG1, GAS6",142,43,16881,8.293973141,0.999999941,0.559342279,0.543804994
MES,GOTERM_BP_DIRECT,GO:0051496~positive regulation of stress fiber assembly,3,2.013422819,0.05030337,"SDC4, TPM1, LPAR1",145,42,16792,8.271921182,1,0.599070954,0.584207718
MES,GOTERM_BP_DIRECT,GO:0071799~cellular response to prostaglandin D stimulus,2,1.342281879,0.050369853,"PTGFR, AKR1C3",145,6,16792,38.60229885,1,0.599070954,0.584207718
MES,GOTERM_BP_DIRECT,GO:0032964~collagen biosynthetic process,2,1.342281879,0.050369853,"COL1A1, COL5A1",145,6,16792,38.60229885,1,0.599070954,0.584207718
MES,GOTERM_BP_DIRECT,GO:0022038~corpus callosum development,2,1.342281879,0.050369853,"LPAR1, EPHB2",145,6,16792,38.60229885,1,0.599070954,0.584207718
MES,GOTERM_BP_DIRECT,GO:0048845~venous blood vessel morphogenesis,2,1.342281879,0.050369853,"CCBE1, HEG1",145,6,16792,38.60229885,1,0.599070954,0.584207718
MES,GOTERM_BP_DIRECT,GO:0045429~positive regulation of nitric oxide biosynthetic process,3,2.013422819,0.052467851,"DDAH1, CLU, EGFR",145,43,16792,8.079550922,1,0.618950015,0.603593571
MES,GOTERM_MF_DIRECT,GO:0002020~protease binding,4,2.684563758,0.052620881,"ITGB1, CCBE1, SERPINE1, F3",142,101,16881,4.708129968,0.999999975,0.568305514,0.55251925
MES,GOTERM_BP_DIRECT,GO:0043547~positive regulation of GTPase activity,10,6.711409396,0.054480848,"ITGB1, FGF5, RGS4, ERRFI1, ANGPT1, ARHGEF28, CCL2, NRG1, RIN2, EGFR",145,565,16792,2.049679585,1,0.63751379,0.62169677
MES,GOTERM_CC_DIRECT,GO:0016528~sarcoplasm,2,1.342281879,0.055124717,"SPOCK1, FLNC",148,7,18224,35.18146718,0.999984223,0.316156465,0.275623585
MES,KEGG_PATHWAY,hsa04514:Cell adhesion molecules (CAMs),5,3.355704698,0.056061109,"ITGB1, VCAN, ALCAM, SDC4, CDH2",71,142,6879,3.411525491,0.999585596,0.401279518,0.371773671
MES,GOTERM_MF_DIRECT,GO:0005024~transforming growth factor beta-activated receptor activity,2,1.342281879,0.05703313,"LTBP1, TGFBR2",142,7,16881,33.96579477,0.999999995,0.596088195,0.579530189
MES,GOTERM_BP_DIRECT,GO:0071679~commissural neuron axon guidance,2,1.342281879,0.058516328,"NRP1, EPHB2",145,7,16792,33.08768473,1,0.660260165,0.643878796
MES,GOTERM_BP_DIRECT,GO:0048251~elastic fiber assembly,2,1.342281879,0.058516328,"LOX, THSD4",145,7,16792,33.08768473,1,0.660260165,0.643878796
MES,GOTERM_BP_DIRECT,GO:0001961~positive regulation of cytokine-mediated signaling pathway,2,1.342281879,0.058516328,"AXL, GAS6",145,7,16792,33.08768473,1,0.660260165,0.643878796
MES,GOTERM_BP_DIRECT,GO:0060119~inner ear receptor cell development,2,1.342281879,0.058516328,"FZD2, ATP8B1",145,7,16792,33.08768473,1,0.660260165,0.643878796
MES,GOTERM_BP_DIRECT,GO:0002576~platelet degranulation,4,2.684563758,0.058798582,"SERPINE1, VEGFC, GAS6, CLU",145,103,16792,4.497355206,1,0.660260165,0.643878796
MES,GOTERM_BP_DIRECT,GO:0003151~outflow tract morphogenesis,3,2.013422819,0.059154942,"FZD2, CITED2, TGFBR2",145,46,16792,7.552623688,1,0.660260165,0.643878796
MES,GOTERM_BP_DIRECT,GO:0009267~cellular response to starvation,3,2.013422819,0.061446181,"CAV1, AKR1C3, GAS6",145,47,16792,7.391929567,1,0.671772182,0.655105195
MES,GOTERM_BP_DIRECT,GO:0051781~positive regulation of cell division,3,2.013422819,0.061446181,"FGF5, PDGFC, VEGFC",145,47,16792,7.391929567,1,0.671772182,0.655105195
MES,GOTERM_CC_DIRECT,GO:1903561~extracellular vesicle,3,2.013422819,0.061564166,"COL6A2, COL12A1, EDIL3",148,50,18224,7.388108108,0.999995842,0.343000356,0.299025952
MES,GOTERM_BP_DIRECT,GO:0001764~neuron migration,4,2.684563758,0.061575259,"NRP1, AXL, SPOCK1, GAS6",145,105,16792,4.411691297,1,0.671772182,0.655105195
MES,GOTERM_BP_DIRECT,GO:0042698~ovulation cycle,2,1.342281879,0.0665934,"AXL, EGFR",145,8,16792,28.95172414,1,0.710492821,0.692865156
MES,GOTERM_BP_DIRECT,GO:2000020~positive regulation of male gonad development,2,1.342281879,0.0665934,"CITED2, SOX9",145,8,16792,28.95172414,1,0.710492821,0.692865156
MES,GOTERM_BP_DIRECT,GO:0032825~positive regulation of natural killer cell differentiation,2,1.342281879,0.0665934,"AXL, GAS6",145,8,16792,28.95172414,1,0.710492821,0.692865156
MES,KEGG_PATHWAY,hsa04390:Hippo signaling pathway,5,3.355704698,0.06721844,"FZD2, WNT5B, WNT5A, SERPINE1, TGFBR2",71,151,6879,3.208189535,0.999916767,0.457085391,0.423476171
MES,GOTERM_CC_DIRECT,GO:0030139~endocytic vesicle,3,2.013422819,0.070451024,"LPAR1, CCL2, EGFR",148,54,18224,6.840840841,0.99999935,0.373244091,0.325392284
MES,GOTERM_CC_DIRECT,GO:0005783~endoplasmic reticulum,12,8.053691275,0.071776607,"EXT1, ATP8B1, STC2, CAV1, TPBG, DSE, PXDN, RRAS2, ITGA5, TFPI, CLU, TGM2",148,828,18224,1.784567176,0.999999508,0.373244091,0.325392284
MES,GOTERM_MF_DIRECT,GO:0005088~Ras guanyl-nucleotide exchange factor activity,4,2.684563758,0.071786779,"FGF5, ANGPT1, NRG1, EGFR",142,115,16881,4.13496632,1,0.705210605,0.685621421
MES,GOTERM_MF_DIRECT,GO:0030296~protein tyrosine kinase activator activity,2,1.342281879,0.07272671,"NRG1, GAS6",142,9,16881,26.41784038,1,0.705210605,0.685621421
MES,GOTERM_CC_DIRECT,GO:0031594~neuromuscular junction,3,2.013422819,0.072734746,"ITGB1, SPOCK1, NRG1",148,55,18224,6.716461916,0.999999597,0.373244091,0.325392284
MES,GOTERM_BP_DIRECT,GO:0007165~signal transduction,16,10.73825503,0.07295841,"NRP1, PDE1C, SDC4, VEGFC, EGFR, EXT1, ALCAM, AXL, PLAU, RAC2, SPOCK1, CCL2, IGFBP6, SOX9, GAS6, RIN2",145,1161,16792,1.595960676,1,0.751715288,0.733064875
MES,GOTERM_MF_DIRECT,GO:0005516~calmodulin binding,5,3.355704698,0.074003582,"CNN2, RGS4, PDE1C, EGFR, MYLK",142,189,16881,3.144980997,1,0.705210605,0.685621421
MES,GOTERM_BP_DIRECT,GO:0010469~regulation of receptor activity,2,1.342281879,0.074601655,"PLAU, SERPINE1",145,9,16792,25.7348659,1,0.751715288,0.733064875
MES,GOTERM_BP_DIRECT,GO:0060068~vagina development,2,1.342281879,0.074601655,"AXL, WNT5A",145,9,16792,25.7348659,1,0.751715288,0.733064875
MES,GOTERM_BP_DIRECT,GO:0001960~negative regulation of cytokine-mediated signaling pathway,2,1.342281879,0.074601655,"CAV1, PXDN",145,9,16792,25.7348659,1,0.751715288,0.733064875
MES,GOTERM_BP_DIRECT,GO:0035457~cellular response to interferon-alpha,2,1.342281879,0.074601655,"AXL, GAS6",145,9,16792,25.7348659,1,0.751715288,0.733064875
MES,GOTERM_BP_DIRECT,GO:0007494~midgut development,2,1.342281879,0.074601655,"WNT5A, EGFR",145,9,16792,25.7348659,1,0.751715288,0.733064875
MES,GOTERM_BP_DIRECT,"GO:0035313~wound healing, spreading of epidermal cells",2,1.342281879,0.074601655,"COL5A1, ITGA5",145,9,16792,25.7348659,1,0.751715288,0.733064875
MES,GOTERM_BP_DIRECT,GO:0008354~germ cell migration,2,1.342281879,0.074601655,"ITGB1, PLPP3",145,9,16792,25.7348659,1,0.751715288,0.733064875
MES,GOTERM_BP_DIRECT,GO:0000165~MAPK cascade,6,4.026845638,0.075253373,"FGF5, ANGPT1, CAV1, CCL2, NRG1, EGFR",145,262,16792,2.652066333,1,0.75305272,0.734369124
MES,GOTERM_BP_DIRECT,GO:0030168~platelet activation,4,2.684563758,0.076347159,"COL1A1, AXL, RAC2, GAS6",145,115,16792,4.028065967,1,0.758765262,0.739939935
MES,GOTERM_BP_DIRECT,GO:0001701~in utero embryonic development,5,3.355704698,0.0773949,"ITGB1, ANGPT1, HEG1, TPM1, TGFBR2",145,187,16792,3.096441084,1,0.758783781,0.739957994
MES,GOTERM_BP_DIRECT,GO:0016055~Wnt signaling pathway,5,3.355704698,0.0773949,"TLE4, WNT5B, WNT5A, AMOTL2, DKK3",145,187,16792,3.096441084,1,0.758783781,0.739957994
MES,GOTERM_BP_DIRECT,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,14,9.395973154,0.078570349,"DDX58, CITED2, WNT5A, SERPINE1, GLIS3, NRG1, CYR61, EGFR, ARNTL2, ZEB1, IRF1, CDH13, TCF4, SOX9",145,981,16792,1.65269781,1,0.765138098,0.746154657
MES,GOTERM_BP_DIRECT,GO:0032060~bleb assembly,2,1.342281879,0.082541675,"LPAR1, MYLK",145,10,16792,23.16137931,1,0.793165371,0.773486561
MES,GOTERM_BP_DIRECT,GO:0003149~membranous septum morphogenesis,2,1.342281879,0.082541675,"FZD2, TGFBR2",145,10,16792,23.16137931,1,0.793165371,0.773486561
MES,KEGG_PATHWAY,hsa05231:Choline metabolism in cancer,4,2.684563758,0.083160011,"PDGFC, RAC2, PLPP3, EGFR",71,101,6879,3.83712174,0.999991879,0.538560071,0.498960066
MES,GOTERM_BP_DIRECT,GO:0007417~central nervous system development,4,2.684563758,0.084265774,"VCAN, ZEB1, CITED2, PDGFC",145,120,16792,3.860229885,1,0.804405511,0.784447828
MES,GOTERM_BP_DIRECT,GO:0006935~chemotaxis,4,2.684563758,0.087528183,"PLAU, RAC2, CCL2, CYR61",145,122,16792,3.796947428,1,0.820953886,0.80058563
MES,GOTERM_MF_DIRECT,GO:0005003~ephrin receptor activity,2,1.342281879,0.088160926,"EPHB2, EPHA2",142,11,16881,21.61459667,1,0.726156382,0.705985372
MES,GOTERM_MF_DIRECT,GO:0043394~proteoglycan binding,2,1.342281879,0.088160926,"COL5A1, SLIT2",142,11,16881,21.61459667,1,0.726156382,0.705985372
MES,GOTERM_BP_DIRECT,GO:0051592~response to calcium ion,3,2.013422819,0.088483157,"CAV1, KCNMA1, EGFR",145,58,16792,5.990011891,1,0.820953886,0.80058563
MES,GOTERM_BP_DIRECT,GO:0048333~mesodermal cell differentiation,2,1.342281879,0.090414039,"ITGB1, ITGA2",145,11,16792,21.05579937,1,0.820953886,0.80058563
MES,GOTERM_BP_DIRECT,GO:0010759~positive regulation of macrophage chemotaxis,2,1.342281879,0.090414039,"CSF1, CCL2",145,11,16792,21.05579937,1,0.820953886,0.80058563
MES,GOTERM_BP_DIRECT,GO:0003181~atrioventricular valve morphogenesis,2,1.342281879,0.090414039,"CYR61, TGFBR2",145,11,16792,21.05579937,1,0.820953886,0.80058563
MES,GOTERM_BP_DIRECT,GO:0033628~regulation of cell adhesion mediated by integrin,2,1.342281879,0.090414039,"PLAU, EPHA2",145,11,16792,21.05579937,1,0.820953886,0.80058563
MES,GOTERM_BP_DIRECT,GO:0009612~response to mechanical stimulus,3,2.013422819,0.091091368,"CITED2, CCL2, TGFBR2",145,59,16792,5.888486265,1,0.820953886,0.80058563
MES,GOTERM_BP_DIRECT,GO:0030097~hemopoiesis,3,2.013422819,0.091091368,"CNN2, CSF1, ANGPT1",145,59,16792,5.888486265,1,0.820953886,0.80058563
MES,GOTERM_BP_DIRECT,GO:0051216~cartilage development,3,2.013422819,0.091091368,"ZEB1, WNT5A, SOX9",145,59,16792,5.888486265,1,0.820953886,0.80058563
MES,GOTERM_MF_DIRECT,GO:0046872~metal ion binding,24,16.10738255,0.092634827,"ITGB1, GPR39, NRP1, PDE1C, ITGA2, ARHGEF28, GLIS3, ANTXR2, TGFBR2, MYLK, EXT1, ADAM19, COL1A1, ZEB1, COL5A1, DDAH1, KCNMA1, ADAM12, DPYD, ITGA11, PXDN, AOX1, ITGA5, TGM2",142,2069,16881,1.378988284,1,0.726156382,0.705985372
MES,GOTERM_MF_DIRECT,GO:0032403~protein complex binding,5,3.355704698,0.094281061,"ITGB1, RRAS, ITGA2, KRT8, FBN1",142,206,16881,2.88544373,1,0.726156382,0.705985372
MES,GOTERM_MF_DIRECT,"GO:0046934~phosphatidylinositol-4,5-bisphosphate 3-kinase activity",3,2.013422819,0.09476061,"FGF5, NRG1, EGFR",142,62,16881,5.752271695,1,0.726156382,0.705985372
MES,GOTERM_MF_DIRECT,GO:0046982~protein heterodimerization activity,8,5.369127517,0.095154572,"EXT1, ITGB1, AXL, ITGA2, CAV1, TCF4, SOX9, EGFR",142,465,16881,2.045252158,1,0.726156382,0.705985372
MES,GOTERM_BP_DIRECT,GO:0001934~positive regulation of protein phosphorylation,4,2.684563758,0.09591333,"SOX9, GAS6, CYR61, EGFR",145,127,16792,3.647461309,1,0.83342824,0.812750489
MES,GOTERM_MF_DIRECT,GO:0098641~cadherin binding involved in cell-cell adhesion,6,4.026845638,0.096085799,"CNN2, ITGB1, KRT18, FSCN1, EGFR, EPHA2",142,290,16881,2.459592035,1,0.726156382,0.705985372
MES,GOTERM_BP_DIRECT,GO:0007416~synapse assembly,3,2.013422819,0.096374582,"BDNF, WNT5A, NRG1",145,61,16792,5.695421142,1,0.83342824,0.812750489
MES,GOTERM_BP_DIRECT,GO:0001933~negative regulation of protein phosphorylation,3,2.013422819,0.096374582,"ANGPT1, SLIT2, PLPP3",145,61,16792,5.695421142,1,0.83342824,0.812750489
MES,GOTERM_MF_DIRECT,GO:0019904~protein domain specific binding,5,3.355704698,0.096824269,"EHD2, BASP1, WNT5A, RAB27B, TGM2",142,208,16881,2.857699079,1,0.726156382,0.705985372
MES,GOTERM_MF_DIRECT,GO:0042802~identical protein binding,11,7.382550336,0.096937748,"COL1A1, SRPX2, SMURF2, DDX58, CAV1, TCF4, AMOTL2, SLIT2, EPHB2, GBP1, EGFR",142,749,16881,1.745905339,1,0.726156382,0.705985372
MES,GOTERM_BP_DIRECT,GO:0097028~dendritic cell differentiation,2,1.342281879,0.098219317,"AXL, GAS6",145,12,16792,19.30114943,1,0.83342824,0.812750489
MES,GOTERM_BP_DIRECT,GO:0043116~negative regulation of vascular permeability,2,1.342281879,0.098219317,"ANGPT1, SLIT2",145,12,16792,19.30114943,1,0.83342824,0.812750489
MES,GOTERM_BP_DIRECT,GO:0090179~planar cell polarity pathway involved in neural tube closure,2,1.342281879,0.098219317,"FZD2, WNT5A",145,12,16792,19.30114943,1,0.83342824,0.812750489
MES,GOTERM_BP_DIRECT,GO:0048596~embryonic camera-type eye morphogenesis,2,1.342281879,0.098219317,"ZEB1, CITED2",145,12,16792,19.30114943,1,0.83342824,0.812750489
MES,GOTERM_BP_DIRECT,GO:0043206~extracellular fibril organization,2,1.342281879,0.098219317,"COL5A1, LTBP2",145,12,16792,19.30114943,1,0.83342824,0.812750489
MES,GOTERM_BP_DIRECT,GO:0030208~dermatan sulfate biosynthetic process,2,1.342281879,0.098219317,"VCAN, DSE",145,12,16792,19.30114943,1,0.83342824,0.812750489
MES,GOTERM_BP_DIRECT,GO:0060444~branching involved in mammary gland duct morphogenesis,2,1.342281879,0.098219317,"CSF1, EPHA2",145,12,16792,19.30114943,1,0.83342824,0.812750489
MES,GOTERM_MF_DIRECT,GO:0051015~actin filament binding,4,2.684563758,0.09861383,"TPM1, FSCN1, FLNC, EGFR",142,132,16881,3.602432778,1,0.726156382,0.705985372
MES,GOTERM_BP_DIRECT,GO:0016525~negative regulation of angiogenesis,3,2.013422819,0.099048451,"CCL2, TCF4, EPHA2",145,62,16792,5.603559511,1,0.835577341,0.81484627
MES,GOTERM_CC_DIRECT,GO:0030666~endocytic vesicle membrane,3,2.013422819,0.099309511,"WNT5B, CAV1, WNT5A",148,66,18224,5.597051597,0.999999999,0.496547555,0.432887612
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0005578~proteinaceous extracellular matrix,7,8.974358974,8.24E-04,"MMP16, PTPRZ1, FLRT3, COL22A1, MGP, COL9A3, GPC4",76,268,18224,6.263157895,0.108280751,0.114556707,0.112908409
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0015629~actin cytoskeleton,6,7.692307692,0.002047386,"SVIL, BFSP1, NFATC2, KALRN, SHROOM4, AIF1L",76,218,18224,6.599710285,0.247894251,0.142293307,0.140245921
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0032587~ruffle membrane,4,5.128205128,0.00469672,"SPRY4, SPATA13, SPRY2, AIF1L",76,82,18224,11.6970475,0.4802368,0.16699218,0.164589415
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0005887~integral component of plasma membrane,14,17.94871795,0.00480553,"CADM3, SLC26A2, CADM4, FLT1, GRIK2, SLC5A3, ART3, MMP16, PTPRZ1, MMP15, FLRT3, HLA-DRA, GPC4, EPHB3",76,1415,18224,2.372475358,0.488075873,0.16699218,0.164589415
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0042803~protein homodimerization activity,9,11.53846154,0.009604003,"WWTR1, TRIM9, CADM3, CADM4, INPP5F, GDNF, FLRT3, GRIK2, TRPM8",70,730,16881,2.973170254,0.780217267,1,1
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0005886~plasma membrane,27,34.61538462,0.0115363,"SLC26A2, FLT1, GRIK2, JPH1, SLC5A3, UGT8, GNG2, PRKAR2B, FLRT3, TRPM8, GPC4, GRASP, TRPM3, EPHB3, PRIMA1, RFTN2, SVIL, CADM3, TNFRSF19, NFATC2, BFSP1, MMP16, CDC42EP5, MMP15, SPRY2, HLA-DRA, FREM2",76,4121,18224,1.571054547,0.800684646,0.320709153,0.316094632
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0015798~myo-inositol transport,2,2.564102564,0.012277442,"PGAP1, SLC5A3",70,3,16792,159.9238095,0.996287705,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0016048~detection of temperature stimulus,2,2.564102564,0.016336818,"TRPM8, TRPM3",70,4,16792,119.9428571,0.999425319,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0007254~JNK cascade,3,3.846153846,0.017281376,"CDC42EP5, TNFRSF19, ARHGEF6",70,49,16792,14.68688047,0.999628104,1,1
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0005856~cytoskeleton,6,7.692307692,0.018387456,"TRIM9, PPP2R2B, CDC42EP5, SPRY2, DNAH9, SNTB1",76,371,18224,3.877996879,0.924199192,0.425976067,0.419846915
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0008344~adult locomotory behavior,3,3.846153846,0.01933272,"INPP5F, GDNF, LGI4",70,52,16792,13.83956044,0.999855681,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0050951~sensory perception of temperature stimulus,2,2.564102564,0.020379751,"TRPM8, TRPM3",70,5,16792,95.95428571,0.999911047,1,1
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0005925~focal adhesion,6,7.692307692,0.022486406,"SVIL, FLT1, FLRT3, SPRY4, SNTB1, AIF1L",76,391,18224,3.679633867,0.957628873,0.446515768,0.440091081
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0048598~embryonic morphogenesis,2,2.564102564,0.024406307,"FLT1, FLRT3",70,6,16792,79.96190476,0.999986233,1,1
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0031012~extracellular matrix,5,6.41025641,0.033746188,"MMP16, SERPINE2, MMP15, LAMA4, MGP",76,296,18224,4.050497866,0.991533974,0.586340024,0.577903477
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0016477~cell migration,4,5.128205128,0.033822947,"FLT1, SPATA13, NFATC2, EPHB3",70,172,16792,5.578737542,0.99999983,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0030334~regulation of cell migration,3,3.846153846,0.037177379,"SERPINE2, LAMA4, SPATA13",70,74,16792,9.725096525,0.999999965,1,1
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0005089~Rho guanyl-nucleotide exchange factor activity,3,3.846153846,0.039581266,"SPATA13, KALRN, ARHGEF6",70,77,16881,9.395732839,0.998236734,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0035023~regulation of Rho protein signal transduction,3,3.846153846,0.043790709,"SPATA13, KALRN, ARHGEF6",70,81,16792,8.884656085,0.999999998,1,1
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0030165~PDZ domain binding,3,3.846153846,0.048304615,"GRIK2, GRASP, SNTB1",70,86,16881,8.412458472,0.999579099,1,1
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0030676~Rac guanyl-nucleotide exchange factor activity,2,2.564102564,0.055749232,"SPATA13, KALRN",70,14,16881,34.45102041,0.999877337,1,1
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0005102~receptor binding,5,6.41025641,0.056350638,"CADM3, CADM4, SERPINE2, GDNF, LAMA4",70,353,16881,3.415823553,0.999889013,1,1
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0004867~serine-type endopeptidase inhibitor activity,3,3.846153846,0.059812428,"SERPINA3, SERPINE2, ITIH6",70,97,16881,7.458468336,0.999937673,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0031175~neuron projection development,3,3.846153846,0.06368554,"GDNF, FLRT3, CLMN",70,100,16792,7.196571429,1,1,1
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0005576~extracellular region,12,15.38461538,0.064472163,"SERPINA3, SERPINE2, GDNF, LGI4, LAMA4, COL22A1, ITIH6, CFI, LOXL3, COL9A3, SEMA3E, EPHB3",76,1610,18224,1.787250736,0.999905184,0.995736746,0.981409599
CLS2_vs_OTHER_UP,GOTERM_CC_DIRECT,GO:0043034~costamere,2,2.564102564,0.075399694,"SVIL, SYNM",76,19,18224,25.24099723,0.999981481,1,0.992753623
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0005085~guanyl-nucleotide exchange factor activity,3,3.846153846,0.084025501,"SPATA13, KALRN, ARHGEF6",70,118,16881,6.131113801,0.999998963,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0008037~cell recognition,2,2.564102564,0.086656504,"CADM3, CADM4",70,22,16792,21.80779221,1,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0010951~negative regulation of endopeptidase activity,3,3.846153846,0.08848506,"SERPINA3, SERPINE2, ITIH6",70,121,16792,5.947579693,1,1,1
CLS2_vs_OTHER_UP,GOTERM_MF_DIRECT,GO:0070006~metalloaminopeptidase activity,2,2.564102564,0.08995865,"MMP16, MMP15",70,23,16881,20.97018634,0.999999626,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,"GO:0051966~regulation of synaptic transmission, glutamatergic",2,2.564102564,0.090414447,"SERPINE2, KALRN",70,23,16792,20.85962733,1,1,1
CLS2_vs_OTHER_UP,GOTERM_BP_DIRECT,GO:0007422~peripheral nervous system development,2,2.564102564,0.094157151,"UGT8, SLC5A3",70,24,16792,19.99047619,1,1,1
CLS2_vs_OTHER_UP,KEGG_PATHWAY,hsa04360:Axon guidance,3,3.846153846,0.099422731,"NFATC2, SEMA3E, EPHB3",30,127,6879,5.416535433,0.999832026,1,1
CLS2_vs_OTHER_DOWN,KEGG_PATHWAY,hsa04380:Osteoclast differentiation,2,33.33333333,0.019043466,"PIK3CD, FOSL2",2,131,6879,52.51145038,0.724238128,1,1
CLS2_vs_OTHER_DOWN,GOTERM_BP_DIRECT,GO:0030335~positive regulation of cell migration,2,33.33333333,0.053606635,"ZNF703, PIK3CD",6,184,16792,30.42028986,0.965296529,1,1